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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ART4</accession>
    <name>A0A8H5ART4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000613">
        <property type="protein sequence ID" value="KAF5309738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ART4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5309738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="428" mass="41810" checksum="156816D69810C697" modified="2022-01-19" version="1">MENEADGADGADEADKADEADGADKADGADGTDGTDKADKADGADEADEADGADEADEADGADEADGADEADGADEADGADEADEADGADGADGADEADGANEADEADGADEADEADGADEADEADGADGADGADGADEADEADGADEADEADGADGADGQTGQTGQTGQTGQTGQTGQTGQTGQTGQTGQTGQTGRRGRRADGADGADGADEADEADEADEADEADEADEADEADEADGADEADEADGADEADGADEADEADGADEADGADEADEAAGADGADGADRADEADGANEADEGDRADKADGADRTDGTDKADEADRADKADEADRADKADEADGADKADEEDGADEADEADEADGADEADEADEADGADEADEADGADKADKADRADEADGAEGADKADKADKADKADKADEADEACKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTE0</accession>
    <name>A0A8H5BTE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000375">
        <property type="protein sequence ID" value="KAF5328012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTE0"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5328012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50108" checksum="78BCF2B74F1F5730" modified="2022-01-19" version="1">MAQSLTPTVQEITKESERIAVQNPNSRRRQGTVLLTFQSFICLRSPEQTQTGAGKTTLIKKAFNVETLQSSHNRVGISNIEEEIISKENDRFVIHDSQGYEPGDTTKFEELERFIGQRSGDAKPSDKIHIIWLCIATPYAGGRVLETGTESLLKSVPKDIAMVVVFTKYDELVDSKEMEIYDNDPDIDDEALNESSREKAAADFEVFCVEPLKRFTSRTPGSSMPPYAKVSTRKNYEHMLSELVRTTEKQITLSMGPAREAEEPTEEVSGVMESPPALLAMAQMVDTDTKIALVIRVGKQKYWRGLASSTHFPGLGLRACLSVLHKDIVIPWNINDPEKLLLSDEFESSKSIGLAGSIAGVSGAVAGPVAPIVAPTVFVGVLFAHWVYETYKSTPDTKIIEEYQKSSLYSTLSNEINQFIRKTKMFQYGTKDHVLEKLEELISLKYPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C027</accession>
    <name>A0A8H5C027_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000307">
        <property type="protein sequence ID" value="KAF5332379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C027"/>
    <dbReference type="OrthoDB" id="3123112at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="232"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="343" mass="38361" checksum="406E8E75192E2234" modified="2022-01-19" version="1">MNSKYKKEKFGKELDAIGKIYLENGEELYNNCQQQPGLHAHQSIPQVHYYFWEGENSIILPSNPALLCSHFLRLAFSHLPFFGPEPSTSTVPSPDMTHTPLLLSTPPSAIPTARPSPTLIPNSSPLPVSPAPLSPIASPITDIDMSSATLENLLQALVNNQNQLQQAITNLVNRPTHESSDKTAKPAPFKGEPAKLDSFLSLFILWAGEQKRLKLDSGKLDPQKCIAEALLMMEGPAAEWAAEYAHHISRVQADEAGVVFPWEGNWNNFTHALKVQFRVANEQQLAKNKLEALKQEDKTVVEFSQIFKMWAEKTGFLDQDLQYKFRKRLHKDLKCGARTEGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C212</accession>
    <name>A0A8H5C212_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C212"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="58" mass="6514" checksum="AF97877F4770BDD4" modified="2022-01-19" version="1">MGSEEAAIPDSTRPSTTVHETVVLQIPSTPTCPLYWFIPLPRLIPSEFQVVLPKRHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C252</accession>
    <name>A0A8H5C252_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C252"/>
    <dbReference type="OrthoDB" id="4760524at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="423" mass="47337" checksum="0D950E42B4213E31" modified="2022-01-19" version="1">MQHSTHSTSANAAPQFFSQAHHVIFDRSQVNQVAGNVNQNYFSQLSSSKELGLQRLYEAVSGLGALHDSQARFPPPKCQEGTRELILRELSDWIEADSSERLTSFHNRTGTPTIDPPINSTVPTLPMTELTPTHTSCDVRKPSEVKVHWLYGPAGTGKSAIAQTLCERYDRFGEKKHLAASFFFSRGDSKRNNPTYLFLSIAYSLATTCRDSALRAAIDKAVQEQPGIFEASLEVQYRQLIVEPLQSLSRLRRLRLPTLIVIDGLDECIVAEFQMLVLKIITGISNSNPFTPIQKISLRFLMASRPEPAIRDFVNQARFLEISNRTVLDDNHATYMDIKLYLHDGFSRIHAAWSDVSSFPSPWPPAGVLDELLQRASGQFIYADTVLKYVGEQNSYPPERLDNILGLPVSDATAFADLDTLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3J2</accession>
    <name>A0A8H5C3J2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3J2"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5334565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="468" mass="52602" checksum="4694A03E537747B7" modified="2022-01-19" version="1">MMFPTTASHVIKFVSVGGSIAGLSAAYFLRQAGHNVIVLEKNHVDDFTDQKCCGLRVPPNMSRVMKSVPGMEKLLREKATKSRGILFREEGTSELIGKMVYEQEIMSDLGSDFYRIPYSDLWKHLYELCKSCNVEFKFGFEVEGIQVGIPDQPAIVSSTRGENIVCDIVLGCDGHRSFIRKMITQEDDSDSDDGLVIQSDASEPRMFPEMDQWTTSRICVPIPQMLKDPQLKKLADEDWWTMWLTDGTLFIGGNEGPDQYALTLMCNYPRYGGKDMTWDDASSTQLLSEDITKVKETDLQKLLRIGASHHVFCQNPRNTLTRHNNDSNQIVVIGAAAQGALLNGSHNSAMAFEDAMTLGYLFSHLNSPAAIPLLLNGFSEIRCAHTNMVKVSDENCIHLTSMPQGPHQQSRDAAFRQTLTVKEGEVDDILAFVWAGFITQFNYDAKEAAEEWWLNWMKMRPEEKAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3U2</accession>
    <name>A0A8H5C3U2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000259">
        <property type="protein sequence ID" value="KAF5334473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3U2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="33962" checksum="4A7B1467855473A9" modified="2022-01-19" version="1">MTPAPWVGPGSSLPPQGYDPSNQWTPSSPMPAQPGFIPPELRNHVPPGGGGTPLPSNVNVEFMGGYPNVAPTSFAGSDSLPAGGDGGMSGGMSGRYPGMTPFEAPMSSPWSTPRMGMGGMGMGTPYMGAGMGMGGLAGSVGGGMPGMGGAMGGMGGMGGIPGGMGGMGMGGMPGGMGMGMGGGMPGMGGGMPGGMPGMGGGMGGMGGGMGGMGGMGSGMDGMGGGIPGGMAPSAPAHDPFSFGQMAETLDYLYPSSHLTGSTGDHLPPFTAGPGYGPVLTPLQLSILGVLPILNPLLAPLPNSKLTKPTHTLNGIYSSQVQRVNALMTHLMFLGRKVEQIQLHFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4Q5</accession>
    <name>A0A8H5C4Q5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000271">
        <property type="protein sequence ID" value="KAF5334073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4Q5"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="616" mass="70205" checksum="3ADF558292CB90ED" modified="2022-01-19" version="1">MGSVYVNRLQGRAIRLLQILPADPDEQLECQLIEVSLDALPTYEALSYVWGDANPRESILCNDQAMEITRSLAQALRKLRPFKGEEVDDRLATVSNISARVVWADAICINQDDIPERNHQVQLMRDISSNAARVMVWLGLDNCGQASKAVAAIQLVTHFLSTYQAFSKDMRQKNVTWDNQGHGHFTFELCETLFHSKSLQDPWTSIRVFFDLPWWSRIWCVQEAFLAGKVAMLYGDECVDGRDVAVFSEWYMREAQYAGDTPQGSSREAIKRANNVFNHRDRDARHLFMVCEDFRDLQATNPRDKVYGLLGLWRPTEKEKNPIEIDYNKSVAGVYTDVVLMAIRDLRDLFVLRFVDHDHDSDDGFPSWVPRWDHGTPQAHTFLWLNKSRLSASKFYAEEPDEALACSGILQVKGVLFDRVVSTSSVLKGGRESFMTDATFRQSFIELWLEAKGERPNTKYPHQVSVTELATTVTFGIIKGSKERRDRDITQPDAWLDIGDLDTEAVHEFLSSFHTFMDSEKYPGNAGAFVQLLDAVHGRRLFRTSRGHLGLGRSGIRDGDFVSVLHGGRVPFVLRPVTSEAHFRLVGDCYVYDIMNRQVYEMFDVEGVKPGVFEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C547</accession>
    <name>A0A8H5C547_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000245">
        <property type="protein sequence ID" value="KAF5335256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C547"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5335256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="817" mass="91078" checksum="4E8ECD8494462979" modified="2022-01-19" version="1">MTSRQTRSQGSVPNIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPPDPLIQNPLPFALDPIMSDAGENTRTDVRDTVPTPSSSPPSTPTSSVALSMPENTNPHYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNSALWVIRHQHFKSSGLHPGNTVKLACFNAITGKINDKIMIHYIEESDAIELIKKLKQRFDPSSTVQESNELWKLFNLCKPVWEFDKLLDKAQILGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYTAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGECANAAAPYQKPSDGKKDRKCFSCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPVSSSQIATTSTSQSDWVQSISSGDVEMEDSETPVSRHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLRLAGDMRVEVRKDNGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTNETPTSQEHEPEPMDVDEDKTKQPDGPRRSKRIREARGLLYDEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQRDAWFDSMKAEIESLERTCDYWLNLGSPTITSTYGFADSDGMSTYGNKPIMGYAFKFAESLISWSSKRGTLVTLSVTEAELCALAHASQEAIYLKGFIEEILNAEQEPVLINSDSASTLAIIRAPEEQHTQRTKHFNICKNFLTDRIHQRYIRVKHVSTNDQLADILTKDQVFLPITRDICLKGSVGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6L8</accession>
    <name>A0A8H5C6L8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000234">
        <property type="protein sequence ID" value="KAF5335898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6L8"/>
    <dbReference type="OrthoDB" id="2757916at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="748" mass="80691" checksum="15628EA2FBBF0580" modified="2022-01-19" version="1">MWYKPPSVDYIQKLLHYLNMLQPLTQQSLPDIPPLLLPPLRTASTNVSSTDTHCPSLKRVKSNANIDEYFSQPRSGRTTCGKAVVGESPGDKSTPSAGLVPTLTSTPAHKRTKPRPSPPPTKSQNETLTKIKTVDGDAEDISAALSESLFAEPQTVSRASIAAARLLRLQQEQEKDDNDAFGMSEAQYRNLVSSFSTVKFEFFDLDGLVWTGSALKRANDTAAAAKRRRGSSGTGVGTVSEDKENVDVNESPLRFKRPKQKNEDEGTRFLIVDEDIEGEDGDGEYRGEEDKNQTIRASVSPFTVEALAMLTRPPRSRYRDKSSECATAPVTASTNAKNDTFITTPITTADASATARTRTTRRTRPMGPADVNDFFFPGCNADAGLDSASVSHSSSSFSSSPHPNSKSASALAEVASEAKASIKTDAATSVPRITTPAETKPEAESICRGRPRRTRSQSIMDGGVCGEFVRSRSRSLSRTRDISDSVADGWVGGEEGDGLADADAITIPCKSFLDDSDSDSSVSQPGPGTTGTIRASTFQCRPNAFAVSTRRVSESQSDTALKLDPQEEVEKVKKAAAQDPPPRPPRAPQRLHVQPRHGQDDDRPRPSLTNCKITTMTTPASTAAGEPLSAPPVSLRRSPPKRSKGLVKPKRIRTPLSPTQSHTKSNSKCDASVGPESTSNSAMAKGLEIPRSKAGKGKGSDRRDRDPFATCGRSFRQMMEVEDWSDDYEGYGDLTAGLYPDVVSAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6Y3</accession>
    <name>A0A8H5C6Y3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6Y3"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034431552" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5336230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="33512" checksum="461C229962192311" modified="2022-01-19" version="1">MTGQMWLASFLCLAMTFSGVLGASYTQTESISGSDFYDAFSFQAISDPTHGRVNYVSASAAKSANLTYASSNHFVLRSDFKKQLSSSGPGRDSVRIQSNNQYTTAVMIFNIRHMPQGCGTWPAVWTVGGNWPNQGEIDILEGVNDQSPNQVTLHTNAGCTMPSSRSQTGNAVLNDCNVATTNNAGCGVKLPSSQSYGPSFNSNGGGWYALERRNSGIKVWFWPRNGGVPSEVSSGAGTINTSNWGTPSAYFPSDNCDIASKFGPHNIIINLTFCGDWAGSVYGSSGCPNYVNNNPGAFTDAYFDFAWLNIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8W0</accession>
    <name>A0A8H5C8W0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8W0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="177" mass="20029" checksum="C709C23672A1D453" modified="2022-01-19" version="1">MLSAIDKDDLLSRALKKKVWDVDEESVKRYQFPNRTVMAVASLYLLRNSNAPLGSTTTTTSAASTSSITANSITTNSNSGISYILKYLIPNETPVWLKFKGAVLDVYPETSIPSGKIPIDELDIETVLEDQKDIVNNMYKDWECTLGKFKDEEEKEKEEKEEKEEKEKGKEKKLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBJ6</accession>
    <name>A0A8H5CBJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBJ6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="20593" checksum="FFD1399945605A4C" modified="2022-01-19" version="1">MYKGLKNECSKTQSVCLTKSTPTDQPGLLNSLPDRSNQEMKFFQVAGTTLSLFSAIAEASSVLEGHVDCSGVNGTHCVFMSDTAYIDRKFENSLIACDHWNDDGYTDAKSTTVPPSPCTALLMETVPTQISTLTFSNVKVLARFSAHSRCYVRNGPSKTTGNILVAFVSWIVSLKSSTTAPGANFNVDCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CC17</accession>
    <name>A0A8H5CC17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_014093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000189">
        <property type="protein sequence ID" value="KAF5339047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CC17"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="179"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5339047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="39739" checksum="08CC8B705A7BF151" modified="2022-01-19" version="1">MDQNNDSKLLRDDPSKKWGFADVFLTQFQTSRTDLETRLNAAKETTSEGPGTVSKEILDNLSIDFEKISKSLRGAIGLIPKSDQGSCEAQLKGLEKSLEDLRKSSAPKSKFAFKRKPKAEGSTTTSDASTTVPTTTNPPTAPTLSQDASDESALSSTPNLTLSSRSKEFLVLHSINGLPSASKSSTTRLRSDLALTDLENCVINLITPPLEAALDISAVQIRSLNNCIVLLPKINGSVMVHAIRNCIVLLGCHQFRMHTSQNVDVYLDIRSNPVIEHCSGIRFASYPPSFDTTSDAGESSLESNLSVQDFSHIRSRPSPNWSLLSKDEVEDARLKRVKELVSSGDCGERGDGHVSEVLHSILPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE49</accession>
    <name>A0A8H5CE49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE49"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="20565" checksum="4A3FF2A2D614A10A" modified="2022-01-19" version="1">MLIFCGRSPLTQRLHLTSTVAPPAFALFLLLRNQTIFFFALIFLESTLVEAKYYHWHHRTRLLQNGMFQDVQGYKGDFGETVSGSIASTSSTTSSGSFTTIATTIVASTSGERLLDPSTSSESITAALARHIELSALARHIELFVFLPRSPTANYCIFTTMPSSTAQGEVGSDGAKDDSQQASGNEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CI11</accession>
    <name>A0A8H5CI11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CI11"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5341416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="67" mass="7319" checksum="18A938829AAE74D8" modified="2022-01-19" version="1">MQGKRVFIIQTRQGRALDIHLFTPVISASLSAASVASLLDTALAEPSKREQVVCIYITVSDNWAEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK79</accession>
    <name>A0A8H5CK79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK79"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="691" mass="76387" checksum="646DE480E9BA525D" modified="2022-01-19" version="1">MWSKLVPRLEISKNFGVNFIGNGFFGSTSEWRARTHSSSGTKFKFNKSLALFVYNHPISVNVPSSKTRHSDELDSNVIQPLSMSPTLFESGFPYHSKLKKHTSCINALTFDSVGRFLASGGDDCEIHLWDFHNEDVDMRGPCHTFIGPRNNIFNLEFSISNKYLFAGGTDATIRQYDVASLYTNTLAPEDKLPKSAFLERDIVRDISCFPFNDEVFLSASESGRILRHDLRVNSAIPNHVKASDTIQLSSEVTGVRYHPTMEHLFVTSENLGRVCLRDARLGFGKRSERRDQGVVLQYNTTLTRFSDGKLCKPEASSVTFDSEGKKLAVTMLNFYPTIYGLSDPDPLAVCTTGARPKKANKTLTSVLARNLAMQLHSPTSRTERLEPVRGYSNSCTMKHGSFSRQAPITSSLYPSSHHSTSSPPRTRTHARSGVGDADANYYAAGSDDFRGYVWKVPGVDKLTGMREVLNERMAMEKLMALTGSSEGGLESPAGGLGVGFISSNPDFKNLARDESGKHSVCAPVELDCPCTVLEGHKSIANTVLFHPSFPLILTTGIERYIYVHSPSKSNPFCVKLKRSKGVVNTKEPSQDVAMDVDSASIADKVGKRAESGSRGAEGRGADTRNDDDDEEEEEEEEEEERYTIELFDSILRTEGWADPFDVRGRGRLGEDSSDDDDDDGVQSDSEEDLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLF0</accession>
    <name>A0A8H5CLF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLF0"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034517171" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="44"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="555" mass="62017" checksum="6485E1D561F8617E" modified="2022-01-19" version="1">MRRGLFCASVLVFTSPVTMRRHSFTLLSLGWILPIICPSAGLSDNPTAQDGLCQKTSVVILGAGVAGITAAQALSNQSIHDFIIVERNDYIGGRVAHTNFGFQPDGTPYTVELGANWVQGLGSEGGPENPIWTLAKRYNITNHFSNYSDILTYNETGVMDYTDLLDEFEDAYSIAEQTAGVYLTDNLQDTTMRVGMSVAGWKPKKNMAAQAVEWWELDWETAQNPDSSAFVFGIAGFNSTFYQFSDENNFVFDERGFNAFIIGEASTFLRQNDSRLLLNTEVKNVTYSSDEVIIHNADGTCISASYACTTFSLGVLQNDVVSFNPPLPTWKRTAIESFHMGTYTKIFFQFNETFWDPDTQFFLYADPVQRGYFPVWQSLSTPGFLPGSNIIFVTVVGEESYRIEQQSDEETQAEAMAVLRQMFPEKNIPDPIAFMYPRWSLEPWAHGSYSDWATGVTLEMHQNLRANVDRLWFAGEAYSAEYFGFLQGAWFEGRDVGSRIAGLLGKECTNEDVNGNSVGACGPMKRYQVLHGTTREEEYDIANGWSASSFLTFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CME5</accession>
    <name>A0A8H5CME5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CME5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="640" mass="71494" checksum="1D5816EDFBCBD59B" modified="2022-01-19" version="1">MYNTPMILENKRSSAVSSSSYSYANARISIPDSEISTPSATAQNSTLLTDVTISRFIDYSARLARYQANGKGRFYSLRDDKRDHISKAMSTAFTGRTPLTNLYIAVDKYPSRIAFKIPVLDPRDSRQVKKWQEITYSQFLQDVESFASYWSKVLLKDGIAPRSVVTFFLNGYTYIDILHIYGIFRAGYIPQPMSIVPTALFILPLLEHSKSKALIFELPYAATVKELAQTLGIRTYDALTCLPDYSGQITLPSLPEAKPEDIAIFFHTSGSTSGKPKIVPGNYRWLDAMVTKLIEGMKGSFCHTGQFITTIRHIGSGSTIVQPLDSSNSIPDLVDKLLLPGQVGITQIYTFPVALMHLIRRAQKDESVRKALVELDAVGYGGGSLPVEDEHWASANGINLVNVFASTECAGISMISDGSRYSPHNGLHPVKGTHYRFQPIASESELSPDEGILELVVPPDSSDCPHPSLRSADGLFYTGDLFREISDAPGYYVNCGRDDDWIKMENAARCDTRSIIDVRCASDSTIEDEVRSACQDLISECVVVGRYRPKPVLFVEPLAAWAGFEEVRSESEILDLRSRIYERIRDLHEHRYESERITGPDMIVVVPQKSLPRTETKGNIRRALVEEEYHTTLELIFGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMK0</accession>
    <name>A0A8H5CMK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMK0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="98" mass="10971" checksum="E01C17BAB46053DD" modified="2022-01-19" version="1">MYSKCLEHKALEVYTPPRGNVMGHVASNLGYNYPPTKEELAIFDSPRQAHSEGGHGHGDGVPGNHHNINVPQVWPSDLSQPQQWDMFMANMDQLFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR98</accession>
    <name>A0A8H5CR98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR98"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="422" mass="46193" checksum="C731EBE146A0C2A2" modified="2022-01-19" version="1">MYLLNRFWAPQALDTMPSLAAILDCVIPGSALSGCRMLHLLISSPDHISKMSSGSSFMSTVPELTGPNYTLWASKSKSWLQSQGIAYVLKTPCPRSIEITSIPAAPAGTTAGATADEAADEPSLTQFITTASGNTADWDKDSDKAMGVIKLCITQAIGAKLEDIKTAKEMWATLKNLYGKPGAAEIFQNFKQAMNVEIPRNAHPGAAIDLIKMYLTRINNAGEKHGDPHTSILMSLLGKLKMMSKKRHGRWMQDKCMGTDNDAEMAEEDDRLSDSLISNTGSMDSMEFQQEKEESTKCLRMWEASLIDMGDSDKENIDPNPRTLQEHLQEVVHREIQQEYNEGLEEINRDLDQMSTSNSLGWSEAQSVTPLFKEISMSPGASNSDVDGDADSMPDLEPASNSLDMDIIALGSDSKEEIISSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRD3</accession>
    <name>A0A8H5CRD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRD3"/>
    <dbReference type="OrthoDB" id="3076816at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034501978" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="69" mass="7182" checksum="EC96C483FC2F4025" modified="2022-01-19" version="1">MNAKFFNAILGLFLIVAVTSATAEPVRRQRIPCGDAAPGAVCPSGTVCCDAPTFFNDGHCIPEGDVCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRM0</accession>
    <name>A0A8H5CRM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRM0"/>
    <dbReference type="OrthoDB" id="2870864at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034575913" description="ABM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="150" mass="16546" checksum="B8D11E3742D8577D" modified="2022-01-19" version="1">MLFNSLLLSSLLLFPAWVAAIPRQYDVSNGTQSCEDLLPDASAFPDTTSSGKFMFFIRVQVIEGKQAELEDVISNIDNFVKSGAEPDTLTHRSVRELGQDGNPTGFYTVIEEFTDKEAFITHLLSPAGCRLLREGPSLIASQNLTLVDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRP4</accession>
    <name>A0A8H5CRP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRP4"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="66077" checksum="BCD4C3187E523763" modified="2022-01-19" version="1">MRPRSKGRLRNILSLFAVGFILFYISSKRQYALNLYSQYDEDEDYNDEHPLLHGDSKTTTLPPPLVDVPSEPLKLPPPPPTPEDLEKQRYFPYCPPSKCAYGHWIPRPTPFTTFEEAHQAILFNKNDAGFSLPDPHPPTAEGVEYTEEEKKEGGRKRVLEMVNWIWQSDFGELVKFDVEEFVVRLLRSPGGLIIVGDSLTTQHLITLRHIFLRADFILNENIPSFPFNTKTHPDHFHHTVAGGGGRGEGTHIWQFALNVDHPPCKELVNRFGIFLERAKRPILTHIVDQTLISPEELNKVFRTEWGYEHKHKYTQVEGWEETVAEMFRPREGEKEGGVTEESLLVLSSGAHWSRAGLHGYNEQLPTEVLRRRIEYAYGEMVKSTIRRLSPLPHTTIFFRSISPGHPTCHLPSITTPFSSLSAAKEWFSQPGNDQAEVVDWDWDSFESRNEIWRRRIGEYEKDRTRGGIDDGKQEGEGEGLGGEVDETWLWKGKGARFVYLDFWSMDLQRIDAHTLTETRKGHFDCLHYALPYLHNQWTELLFHRLVVEKRVEEYRAAKELKEKGARAKGEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRZ7</accession>
    <name>A0A8H5CRZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRZ7"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5346926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="481" mass="51123" checksum="62D0F00441DACD8E" modified="2022-01-19" version="1">MASSSSSWTPLPGRHKVNIGSSLSRALKARKGSAPTKRNNLPDRDFHSVRYPFKPTSIDSTKPGSLDVKRGSDGSNVVTLEHPTTQPGEAWAFPGNESSAKDWACVLIYDEESGTYTLEKVESFIALEHPERRRSTSRPSPYPPSTTSNTPSINATRQNSADADDDLENAILDSFKEDGDSDGEEDIPLAVTRKKALPPTLVTASSRPTKPLPSRSRTQSQTHPHPQSHSQPVTKPMPPPKVLKVPPIPPTSQSKSKKTAKRATPTFSDAEEEVISFGKPSQPNRPGPSPPASASAPTPASGLELPGTSYTSTYSFPQATPTPVKASKPSATSTTSYSLNAPNSHGKLSLPTTTSAPVAAAVEDSDEDEDWDEVVAPDDGNAGAVGTGVGVDSGDEVEMDDAGEEIDMDLFGTMIEEQLGEEDNDNNHDHQEMDFLAQGLTAGSPEPEPPRPTGAPMSLRQFVGGGDSDDDESSSEESDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUV1</accession>
    <name>A0A8H5CUV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUV1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5348033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="22241" checksum="8A7121939326E1BA" modified="2022-01-19" version="1">MATNITFHPGSVSADERVNLLKQKGVTIWLTGLSASGKSTIACALEQHLLHLHKFSYRLDGDNIRFGLNKDLGFDEKSRNENIRRIGEVSKLFADSCCVAITAFISPYRVDRDFARQIHDQASLPFVEVFVDAPLSVVEQRDPKGLYKKARAGEIKDFTGISAPYEAPANPEIHINTAETDVTESVRIITEYLLAKGYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUV3</accession>
    <name>A0A8H5CUV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUV3"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="497" mass="53403" checksum="E1F89571F19E8E2E" modified="2022-01-19" version="1">MFHPSRTLAHQRNDSDVTIAPLRRPKSNALLHYSLYDFPIVLQDSTYLAGVDLQAWCTTIGGCLAVMATFGYTNAFGVYQDVYTRSGAASAFRISWIGSTQMFFMLAMALPAGKLLDMGYFRQATLFGSVLYVFSLFMVSIAHTDQYYQIFLAQGLGMGIGAGFLYVPAIAVQARHWQDRKALAMGAVTVGSSLGSIFFPIMLNQLFEKPSVGFGWGVRASAFVVLGLLILANLLMSDRRPDDFAEKPKAIPDFKGIMTDVPYLLCVLASFFINLGLFFPYFYIQLFAVLHNIDNNIAFYFLAILSAASLPGRLLPNILADRVGPFNVIVPIICIAGALIFAMFGIGSGSSATVGGITAFSIFYGFFSGAFISLCPACLAVLSRTPDEVGVRFGIAYFLAGFGVLFGTPIDGRLLGDLHTNTNTNPNAGTGASAIPNPNGGGNGNNTTSSAGHIVPAIPSLEWSKAIVFSGVTVLVGSVFLLGIRMMLARRKGTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVQ8</accession>
    <name>A0A8H5CVQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVQ8"/>
    <dbReference type="OrthoDB" id="431454at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="100601" checksum="8252299938A59FB4" modified="2022-01-19" version="1">MKPTDNSPDQTGTGSQANILAGAHDFNIVRSTITNIGRDAHYTYNTYLPESKPKEITADDLLLQNPSAPDVFTGRSHLVEESVNLLCEANQVYIAILGTGGIGKTSVVLHIMEHSLITEKFAGRCYFIPCEILPDATNLTQGLVRAIGLQVPQRKGPLGVLLDYLKGCQQSLLILDNFDAPWNGEDQAKVRNFINMICSFKSTSVIVTMRGTDGPGKIKWHKLGGQLGLPPLELGPAKEAFCSFSSDGNYAIKEDDPILEKLLIQMDGMPLAIMLIAQHARELPLQDLMEMWNIQKTTLLKKIGEQDDRLTSIEVSIELTLKVIRGKLSITGQDILRLIAFLPSGIPDWLDSLPKIIGSFPDTNMQVLILKKSCLIYEADSKILKMLTPIGEYISKIFEITEDSENKIWQFYESFMGSLSGNPMHAEIQLQLHVANVFKALDLQLEKSSHINMLNQFYHHSQYFSSIVPLIEKQLKWSVKTDLNEQINMIFLKEYMLTFMGQYKEAESEIEKVQQLTRMLTVTNQSSKLQYQADCYRRLGYIFYYQNHYDESKSMLRRAKEMFESIGNTFGVAQCLRMLGEIACLQSDYNNAKSMLEKAQQLFVKIGEEQGAAHSLRGLGDIYIMFDQYDRAREMLEKAKEQFERAGTKIGVAQCLQRLGNIFRSQEQYAKAKLLLEEAKGQFESAGEKLGAAECLRSLGNICYMQDQYDEARIMLRQAKEQFEDIENRRGVAQCSQLLGDTCRTCGQYQEAKLLLHEAKGCFEDIGDKHGAAQCLQSLGENSRMLHQYEEAKAMLHQAKEQFERLGSRVGAAQCLQHLGNINGSLGEYEDAKIMLQQAKEQFEGSETGWELLSAYNTWETSVEFWANMGKQRSCWSKLRSNLRDLKTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVX9</accession>
    <name>A0A8H5CVX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_014208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVX9"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5348950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="88187" checksum="65378EC7DEB6891F" modified="2022-01-19" version="1">MEALPPLSKTALESFEEKRNPEAKVSLDASFIDEKAPVRNDTVDVDEIGDVFQDDPRLIDLGEDGKERPIETDADYSLRLVSLEDDPSLPIFTFRLWFLGVGLSCFGAVLGQIFYFRPQTVYVSTLFLQIVSYILGKFMEEVIPGTWEGARIKMPDNKFWRWINGGPFNIKEHVAITIMSSTTSQSALAISIFAAQDLYYNVRPNAAIGIFTLIASQLVGYGLAGVMRRFLVYPTFAIYPQLMPNVQLFDALHRGSSSVMQKKRVRFFWIIFIAIFIWEWFPEYIAPTLTGISIFCLADRKNAWFTRIFGKAWYKRSLPIQSWTDISKGGAAGNEGLGLFSICLDWAYVGAGGGTIGSLFTPLSTQLSMYGGVCVCIIAFCAVYAKNVWHAQNFPFLSQLLFNEDGTEYNQLLILNDDFTLNYDKLAKQGLPWYAASQLLYKISRTMYIGAALSHFAIWYGPTFWNIVKHSNEVDDPHYQVPTWWYIGVFIVCVGLAIGTAYGASSGLPWWGVIVALIFAFIFVPVIGTLAATVGYSPSIEIMIQMLGGAVIPGKPVANMYFTVYGYNPVTQAISLMQDLKLGQYTKLPPRATFTVQMIGSIIGGLLNFIIMKTVIAANREILRDVQGSNVWSGQQVQSYNSAAIAWGALGQPLYATGTRYGFVPYMLFAGLGFPIPFWLLHKKWPKFGFNYVFTPILVAELGFLSVGINSATFTSFLLAVFSQYYLRKYRASWFRKYNFLLSAALDGGTSIMIFVWTFAVGGGSGTEHPFPNWALNPKGNPDYCLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW45</accession>
    <name>A0A8H5CW45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW45"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5348648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22384" checksum="39F74EDD35B72CCE" modified="2022-01-19" version="1">MAKTPKNETPGPNSVPNRDIMQRLNFLYQASVYLNSVDTSSPQPTDTEQSWSRRKPNARVGDISRNYIDMMKVVGTKTTVKMDPSVKRTLCKGCSSVLVPGTTATIRTKKSSSHGHAVTYTCMICNESRRLPAPPLSDAEETMPEATMDVDSSAGPQKKSRRKKRANRQVALFARTRMHVVHRGNERVDEDSLRGNGLFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYD1</accession>
    <name>A0A8H5CYD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034508709" description="Phosphoglycerate mutase-like protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="889"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="984"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5350314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1534" mass="166977" checksum="7EF9781D72FD9A69" modified="2022-01-19" version="1">MVALVLLISFGLMVVGTSVLAESFQPLHHSGPASPYFRAPPAAGVPRRLPDGCVVEQAAWFVRHGSRYPEPGSFTGWQNLFAKFQNSTYTARGPLAFIPSWTLPVDDEPHQPLFLSSTGAGEAFALGVSLRKRYGFTKGGENITIWTAGQQRVVDTAVYFTRGYLSAGNYLDEPSSNRGNFVVLVDSATNTTFADSLTPSSSCPAYGVFGGNGSATSNAFRATFQQDIAGRLNEFLDGLVLGTTDIGVMQDLCGFGYEVSGDHRFCDIFTENEWLDYEYAHDLNYYYGSGPGNPLSATVGYPWVKAIADIFNVGPGKMVENGTLIPPPLIMGFSHDNNVPPLISALGLWNSSDTSPLPVTRRESNHQFRSSHLVSFLGNVALERMTCVIDGPSTSDARNLGVFHTANVLGGTVVNASSNGTEEVFVRVLANEAVIPIPTCHSGPGASCPLEQFVGYVNRERKEASGDFVQRCGLEGVEGAVSDVRFLTTTGDGDMLLVDLRGTDLEPSQIPPPYKIWSPAQLDASIRERLCYPTPLNDSLSSLLELCTRPQHTQIFSSPSVYRLYIDCLRHISQGSNYIGRSHPNQSAVKRGNTVVTLKSVNSVDTDAHPYSIPAHRRPTLLLGSGDSNRKPPAPLLNPMDEALMNNIAAEEVTADRSRMAALRIHTRHRSRSDDFSPPRDFLLLPRNEYSAARHYQSRARGPSLTRPGKSKARTSRAVSSPEPLILYRVPPSWDDLIDIQAREDGKVASESSSQTTTLGITSVPSGSKKNSSNSTASIRNTDKARMMLERQRELAVKKRKIESPFGSSSSFPIFSGSATSLESSGRRRPEYVKANQAVVMPSFNGMTDRAKVTVGAKLASGSSGVNEKYASPFRRVSHSMVDKKFTAAATTSTQTSTTPATPSSSSRDSGTYTTPIRSVNHTTMSGGVSSTGKQLKPISTIPIPELPEEEKKKLRARASLDSSARSGSTSAGKKGRGSLPGNGSSSGKWKSGDGTSGDIRSMIRNMGSKAFSYLYPSTSFPVLQLLAMVSPNSFLVAPLRLILLLATTFNLNFAHSYALAVPHYRHSLHSDVIAADRRATHKTHEAHKSTKAQTQGNLTFVENSGICETTDGVGQVSGYVNVEDDSSFWFWFFESRNNPDTDPFTLWLNGGPGCTSMIGLFTEHGPCRINEDRNSTSINPYSWNNFTNILYLDQPFGAGYSTGVEVDSSVEAAKYVWQFFQVLWTNDRFSQYKDRQFILATESFGAHFGPTFIKYFNEKNDLIDSGKLDAEKVAVTHLMINNGKHDSEIGFQSLIDFVTDAPGYGQLAKDDVIEDIKNALPDCSESLQQCNSRQKSDKADDFCNEAIINCTRTIFTPAVGTHNPDFLLSKEGETDNFTDTHYGHFIRLEDVQKAIGADANSPNKLTFDQCDSGVKARFSKAGGTARSGLPDLAELANTGMSILVWGGDADLKANWLGIHESMIEMDWYGNLLFGLTPLSNLTMGGEDVGRYKIVQNLTFAVVNGAGHALTAYKPDVSQMIFSQFATDQPLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D067</accession>
    <name>A0A8H5D067_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D067"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5350763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="600" mass="67446" checksum="E655A2B7A9A69E28" modified="2022-01-19" version="1">MSDAGKNTRTDVRDTVPTPSSSPPSTPTSSVALSMPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNALRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYIEESDAIELIKKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIAQLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAATPYQKPSDGKKDRKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTLQSDWVQSISSGDVEMEDSETPVSHHISLPAFTTISDQDHTHIIDSGATIHCTPYLNLLFNVHTMPVITLTVANSEHLNLRLAGDMRVEVRKDNARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTNETPTSQEHEPEPMDVDEDETKQPGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYTDNVGDPISFKDVLNHPQRDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7Z8</accession>
    <name>A0A8H5D7Z8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7Z8"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="92"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5355235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="524" mass="56895" checksum="28B97745AEAA0BCB" modified="2022-01-19" version="1">MQIDVSPFFCKNKFCQTLRPEQPSANGSSNTETWEAKDGLEYGSKCPSIQPGEKTEKPPSIALVTVEHETNGAPVTTNDARLNFSPRQRSVILAVVCFSGMVNPLSSLMYTPALPAIADALGVSISDVNLTVTTYLIFQGITPSIWGSLSDFYGRRVIYLVTLLITVGSSIGLCLTESFAVVLALRALHATGCSSTRALGVGVIRDIAPINVRGWYMGLYSAGVSVGTSFGPVFGGLLAQYAGWHGIFYFLLALSASSFLLIFLVLPETLHFVRSGRGWTPPRYVQPPLGLSWLADDDDGSSELREGSQSQLSPAHAPKLDFFGPLRIMKYPDAICAMIFTGITYTVWQDNMVATSTIYSSRYGLSEAKIGLTYLANGKGGLVIEHARLRSLSYNVPAFIILNLVYGWIFQAHIHVSVPIILSFLIGYFDSCILAPYSTLMVDLFEEAASTSSASMNLVRCLLGAVGSSTIDLMIRAMGIGWTFTTLSGIMTLGIPLAWYQYRFGYKGRARRLGDDRMQGSQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D835</accession>
    <name>A0A8H5D835_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D835"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="81"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5355324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="584" mass="65208" checksum="936D04F1667B8714" modified="2022-01-19" version="1">MEAFDDENPFDTGVERTPSEDSMGVRVDISEPSSPPFPASKQLSPVQSTQTRPFPSPGSHKQPQANFKSDFCCTRDRVLHSGEEIEILITDAVKTSAGATSPYIAYVIQTGDAVAHHRYSEFESLRLNLVKLYPTIIIPPIPSKQTIGDYAVKQGKAKEDAAMISRRKRMLQTFLNRLARHPILSNEHVFHRFLDGEVSWTEVLNSPPISLLPKNILKAPSHDPTDQNASPAYNALPNPSAAHPLKKPEQRFMDSEAFTNKFASHLSGPMEKVTRRTVKRWSEYAQDNAELGAALNGFSLNESGPLSAAIEKTGQAVDATYISTTKLAQELEQNWAEPIHEYSQFSSIIKKLLAYRHQKHVQYEMTEETLAAKREQLEELEKSENEARRLEEALGRGTPRSMSTSPKLDNTGETGNEPENDQQAERSPSSSSYVPPHPGPNPARRKASVPGMGFINALSYTLHGMMDVDPETARRNNISKTRENISQLEDALHLSAQDLKYSSSTIQADLDRFQRQKVADVREMLISMAKSHHEWCKKNLEAWEDAKREIDKIPDHPNKLPASPSEDPAPSMGRRDSTATVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EZ32</accession>
    <name>A0A8H5EZ32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000475">
        <property type="protein sequence ID" value="KAF5317606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EZ32"/>
    <dbReference type="OrthoDB" id="3066663at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="814" mass="85087" checksum="DD2ABD30473262BA" modified="2022-01-19" version="1">MHMETGLDSASGYTKDGGHGCGPRFGFGSESGSGQARVLETETETKIVVGVCSSPTIPRADSDPQRRENGTNSRNWDETDTKAKVDAEDLNMDLGDADATLTNSKPKPNDSPPKTKKDGDEDERVVDLDSHSHSLVTVSSSSSTPLPPLLSEPQSVSDSDSLRSYPHIPLPFPSTPHTSPSSSWLAPSFPPSDSFPPLSSSSPSLMAISTSSSALPSSSSSPSSSLSPLSLSSPSTIPGVNPNLNSNPTNAMSLILSSLSSTSSLYPLMPSSSSSSSSSSPLLSSSASASSSAVRSPLHLHLSSMTDAPLPPNPNSSPSPTATVPFPFPLSSPPSTPSPITSSFPATSNLNPNPLSTPTSPPSSTSTSTSAFASISTSASTSTSAYTSTSTYTLTSTSTSTSTAQAIANFRLSPREVISGIAPHVFEFDEFGRRIRSRGRGRAGGGSRSRARARRGSVGLVGSGSVGEVKGSGGSGRSDRGARGQGRGQGRGRRKSLGSWDYASASGCGWQQQGQGRGQGHGRYPSEFEFGSQYDFGSDTGIQIQNCHNSQSRPGSRSRSNSLSLISTYRYQCSSLPGSPSPLRVEVVLTTSTSTAGVDDVDNQSDEDEDVDMEKEKEKKGEEEKQPSTPPVHVWLPTLPRIGKQKEKEKQRRPNTATGAESFSWGLSLRRFSGVGIDAGGAGAGAGRVGETMRVEPGPESKASGEPEEKEEDDEKVDLDSDSDSDSKSIYSVRSVRSLRSVVASKRKGKTWKNKNISIDIGDKAKKDKDKLKLGLGLGLGIGIGLGKPIPGARGVPVSMKALKQWIGNGIGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDZ5</accession>
    <name>A0A8H5FDZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000293">
        <property type="protein sequence ID" value="KAF5333013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDZ5"/>
    <dbReference type="OrthoDB" id="3252135at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="470" mass="51471" checksum="BADE2E25DBA8D3D0" modified="2022-01-19" version="1">MFNYRRKRPSNCVSAGPDSRQWNDSMAHTATNFGMSEYLYKALRSCRSSFSPSPPAFTHPFMPLESSLTQNIVSLPPYSDASPPPSYSSNPACGEQSIQLSPRSRTRPTGTWTKKSGSVSLLLMGQDDKASSPSYGRQGSVNGMITLDGRDAVSEVTVKLEGQMYLIIAQGGTETTQMFELSQTLWSSDSSVDITALCPSVIPFNFRFPSTFSVEGRPDIPLPPSIDLHYPGSSGMMVSTTYTLKVKVKARSPTMGFWTKVKRMSVPLDYFPRTRPPYSISNSDLFSDLKIAPEQWHQTVSVIKSRSRDDVPPIDCHLFIPSSKVYALSDTIPFHVNLTGALRSLREFLPSSSSSKDSSPVTVTLLRQTSVEINGERGWKNSTIGKGTVRGIPPPFSHLTCASREGSLDWEGEIQVSKSVLVGGFNAGSLCIKDFIVLSVKPSSSRSYLQSLELAVNVRLVTESAGIPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGE2</accession>
    <name>A0A8H5FGE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGE2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="229" mass="24245" checksum="B88C4238F9357622" modified="2022-01-19" version="1">MSYNSSDNFNNSSSMSGGFGGDSYREGREDNFQSQTSSYGNGMLESLTLSLHTSYLLHPPADNYSTGSTGGDYRNDNNYSNTNSSSGMNNMNDNYSSDNREKMGMSDFNNSSSDSSSFSSGGMTGGSGSGFSGSGSNNDNYRGSSSENDSFGSSGRRSEFDEDSTRSSSGFTSSSGMGSGFGSNSGESMVEKALRIGLKANGLEDAAGRMTRNPEMVERGMEAIEKKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL77</accession>
    <name>A0A8H5FL77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_013567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL77"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="891"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5340438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1227" mass="134972" checksum="6ACC061E8E8C4BE9" modified="2022-01-19" version="1">MLPVWGNEGKRHINLGGTSTSTSQSTILDQAKVRREERLEAKRRSDAAIKVQSWWRGAQEARRVRANVRVELENDLRQGGAETLVGIQTLRKLVIIGKNWKGKEQSISRDGKVVLGIWSERVVASGTDSLFFVHESPSWLTLVKQLSLLIIQSVANDVLSSYTAAYLHVITTILSPSSKVPSHLTASLTSYLVHHGLYSALRRAIQGIPINSKANPALPLLIPLTILPLTTFTNQGASEEYRRTFHHLVTQILTIPLLPNRLPLQTLTYLSANLPLTKLDVLFVNSPNSTSAHAAEPASSSLSSLLSNNYTSGIENKLHLISNLLTLMPPRYPKLTAPSLAAYLRLLSSLVDGIPVGGLEGATASSASEAATGSTPVYADSDEEDGDVIGHVTVVSSFTSVPKTTLPVLDSRTQKRLATLASPTHLISLLTPASKTLTRNEHRYWVIRFLYSLVSVYPGTSSLASSTTKNGNAVGTGNVGKRRREDVLGAVWNWNGGGFVREIWRGWVRGGGLGRDVVQVQTKPKMPDPNSMDVDSSLTGSGIGRSHFDPLLPNPNAGRGQSRLLSLNSQHGANEDPWAPLLLLADLYSQALLTMGDDEFFSSSGSSLSSTLTSTPASGAVSTKNPLTTDDITMFSRQLLNIAWVLYMHGAELGTGSDASTTSTSALAMVPPPSPVSWNEVRERVTKCLLAIHDRDARKPFTPKGHWLVLPDTDSSGESSSSSSSTVHYEGRGRSQMQLSMEMVGFVEAAVVEAQQLTEAADAEEDGEDMRFSSPNSHRGRMNHRTMTSSAASRRQQMYLSPRLAVLNNIPFAIPFHVRVAIFRNFVMQDRVRHLQRINAVRDSGGRRNGAGMMAMFDEFGMGMGGGGRSGRQRVAVRRGMIAQDGFDRLGEADLKNPVEITFIDQFGEEEAGIDGGGVFKEFFTSLCKEVFDTDRGLWLTNKKNELYPNPHAYATETHSLNWYRFIGRILGKAMYEGILVDVAFAGFFLAKWLGKQSFLDDLASLDPDLYNGLIFLKHYAGNPEDLSLNFTVAVEEFGTTRSVDLIRNGSNIAVTKENRLQYIYLVSHFKLSKQIKLQSEAFFEGLSEMIDPKWLRMFDQQEVQILIGGVNSPIDLDDLRANTMYGGLYDDNEDTIVAFWNVVNSFNQEQRRALLRFVTSCSRPPLLGFKELVPNFCIRDAGVDQHRLPTASTCVNLLKLPRYKNEQTLRSKLLQAINANAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL89</accession>
    <name>A0A8H5FL89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000166">
        <property type="protein sequence ID" value="KAF5341350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL89"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="379" mass="42803" checksum="E141BEAE15D7E1AB" modified="2022-01-19" version="1">MKPTYPLQTKSLSNGRSEMSSGNAHLYGFTKSTVDSEHGMPSAYEHASHPPLNRSAGGRQRREANAAQTFYHSLSWTLGFKEKYSLLLFIVFGGALFGFCLARAFMMNTKIMREQTPPGDFRWFDLKMDKIPYFWHIYTTIIGGLIVSAQFLPVIRRQYILVHRLNGYLSLLLLIPGNIAGAIVARRSFGGEINQQIAYYLLGIMITFALLMGFANVKKETRSHRRWMLSMVQPPPHYYQSLRLTGIYRRCCLFRCPNTSTSNGPDLPSSHNKDRQLLVWRCDEVFYVLQSTESLSQLFPQCVANGTDPLSNPLSVAVHASNHEGDLGKSSGARVVHGMCLWISMLISVVGVEIYIRKTETANYNRQGFVLEPKESELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNJ8</accession>
    <name>A0A8H5FNJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNJ8"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="284" mass="29805" checksum="A1A35742C92B97E2" modified="2022-01-19" version="1">MSTQALDLQGKIALVTGGGTGIGLMIAKELSKSGAKVYITGRRLEVLQKTAAETGLFPLQMDVSDKQSIANAVKVIDEAEGKLDILVNNAGIIGFRSELLFGKPAPDSDGGTGTKIGEALFEQDSFEQWTDVFKTNTAGPYFTTMGFLSLLKRGARTREGETSSVIIISSGAGSFKVTSGMIAYPVSKAGANHLTGILATQFALQKIPIRVNCIAPGIFPSELAQELADVAMEPLPGFFNPAPLLRPGRQLEIGSAAVFLSSLAGEFVNGIVMPVDGGLMLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNU0</accession>
    <name>A0A8H5FNU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000142">
        <property type="protein sequence ID" value="KAF5343332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNU0"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="38250" checksum="115353FB36855EB0" modified="2022-01-19" version="1">MTDKTKILITGITGYIGGSVFSRFLKRPDFSSFDIRAIVRSAEKGEKLKNLYGVTPIVGSHSDFSLMENAASEADIVLSMANVDDVDAARATLSGLKKKFEKTGKKGVFINTSGTAVLADNARGEYPGETIYDDADADQIESLSPSQPHRPVDIEIVTADKEGYVDTYIIIPPLIWGKATGRPFDDGLAHGHSFQIPWLVNAAVKRGRAGFIGKGANIWPHVEVHELVEVYSILLDNVLPDSKRPAIVGHGRNGYYFASMHELNFHQVASAIGSALVEAGKGKDAEPTAFTEEEVQKYFGEYGYPVFGSNSRCKTTRMKELGWSPQKDTKDMLNSIRGEVDASIAANSNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP48</accession>
    <name>A0A8H5FP48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP48"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="56473" checksum="2C3EC2B41E53DBB8" modified="2022-01-19" version="1">MTERRSASADPNLRCANRPHVFHPASNQDACYIPENGDNPWVSCKTQPCLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPNQPSETNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSIAPRRPPTPPSPDPSDPNDSVMADTPPIGLNGTSERGRKPDTFNRERSEAKRWLAQFNNYLRMNQGRYPTEESQVALFLSFFAGEKGGDWATQRLTERDADEENEELKATPDQRRWITLKEIRDRFKRDFKPLASEDVARTKIKFAKMRGTDISGYNSVFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWKDFDEYQERAVELHLEWLKERERQGRWKTTSTSKNSSGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPPRTIRTTETASPSPATVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ82</accession>
    <name>A0A8H5FQ82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ82"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="160" mass="17287" checksum="09214555B6DDE532" modified="2022-01-19" version="1">MSLTMSAATSIAHQNSPDRVSANEQRDPESLVLSPTMSESTMSGPQASPASTSPDATDDLERTVSPVHTTSIHAIVTQTQSRSLSLQMFSHSSNSHISDSVLSIVGGNTNTTNNHHNNHHYISIFRGLRLFSVIQIISIPQSKLVRRITWNKTQSLPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSY7</accession>
    <name>A0A8H5FSY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSY7"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23176" checksum="91EC27725500300E" modified="2022-01-19" version="1">MPITEYLTFRTTPQIFKDHDQFVKLRNGAREAGIVNQSYGVGIEDNEVVHWIIQFDQGFGPDKFVWNDVKYGDFGQEIMKIAREPPESAFMSFDGREAFAKEVTASPVTEIATLAIKEDVAKEDVSKILGDISVRLRKAKNSTGASWGEDPKNKPNKVHLFIGWQSIEDHITFTQTDEFKEIGGLMAKIVADASMVHVAFADHASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU37</accession>
    <name>A0A8H5FU37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU37"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="377"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="654" mass="74872" checksum="265D18CB3AA121F6" modified="2022-01-19" version="1">MPLYIVQNESFQQPVSTTCQNPLLSPEASYPTPVSSFMSAINRVTERTEGLSSTSLSKGIATTKANDKAGDLQEWLLQDFNNCYHLTIHDFIKVIFGLTHDRLVELKARMDNKVMSNPDFQASWKKFSESAKVVRPEEPLTGLKRKRETPGRRASNSEGQDDEGKSLPVRYQTLFDLLPSSVISQDMLPSYTSLSHPYTRNVYNKRQKTGMGTVQRYQEDEDEDEDESITTTQGMKVETLVQCANYRLEMLSRGILQYHALGLVIDGMWFQCCYYDRSAIVHSNPINLDEKDHLLLLLVVLNELKVHKPFVSPIPDRTTEVFPLLDPVYCEGYDDYHELASGQEKGLVHDRSGRNAFHGYRLVLDKETELTLGQTIQRSHSIIGRGTTVLHAKCLKGHWGKEGDEVVVKISFVDEGRLSEAKLMDLAKEKAVEDHAWALEHLPEILSVHEYPNSKDSPESRLFEFMRDKLKADSTYELRILRILVLRPLKPITQLNDPKDFAQVFYDILQIHRWLVDHAKILHRDISQNNIMYRVLKDDKVRGVLNDFDLASKLPMSRSHSSQTRSGTRLFMSHELLIPPDQPGLGHFYRHDLESIYYVMLILFANYDKVQEDNNAQKKGIQKVSDHYKAWFKGTDELVGLLKLAALNQSISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU41</accession>
    <name>A0A8H5FU41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU41"/>
    <dbReference type="OrthoDB" id="3027431at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="68"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5349795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="318" mass="34986" checksum="83C2DA0807A1D81C" modified="2022-01-19" version="1">MITFYRSARRRENRVLTPGVISLLAGKPNATTFPFTSFNFTARDPNSPPDAPKDISVNIEEDALAAGLQYGDTAGIPNLLRWLEGLQEKMHGRKVGEGWKICMGSGSQDLIYKVVQAMVNDGDPIFVESPVYAGVIPMFKTLHCEQIEIETDANGICADSLRKTLESWPAGKPKPKVLYTVPYGCNPTGMTATPERRKEVLKLAREYNFIILEDDPYYYVYYGPANRPPSYFTLEATEPTENGEPEVGRVVRFDSLSKILSAGMRIGWASGPEPLMTAIERHLFSLASHLVASASILVSIKTLHGISSGNIADVLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUA4</accession>
    <name>A0A8H5FUA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUA4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5349304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="737" mass="81107" checksum="048B1CE08C2C24EE" modified="2022-01-19" version="1" fragment="single">MSTNLKALADQNEEDQVPLYDFTLFDASENGQFEVVQFLIENGAAVNKATWYGATPLYAASKEGDSEIAQLLLNHGAYVDQPKKNGATPLYMACQNGHIEVVKLLLQHGADIHRASETGVTPLLIASYKGHIEVVTLLLEHRADVDRHMDGGATPLYFACRKGHIKMVKLLLEHRADVDSPMDSDAIPLYSACERGHIKVVKLLLEHGADVDKPRNSGATLLYLACKKGHIEMVKLLLEYGADVDRPADGGATPLYFACRKGCIELMKLLLEHGADIYRTDETGFTPMLIASYKGHIEVVALLLEHRADVNRPMNIGATPLYFACQNGHIEVVKLLLEHGADIYRASETGVAPFLIASENGHLDVVTLLLEHRADVHRPMNNGKTPLYFACQNGHIKVVKLLLEHGADIHKASEIGVTPLLSASENGHLEVVKLLLDHEADVDRPMNSGETPFYFACQNGHIEVVKLLLEHGADIHRASETGFTPLFVASENGYIEVVTLLLEHRADVHRPENSGATPLFIASQNGHLKVVDLLLQNGAKVDQSMNDGVTPLFIASEFGHPEVVKLLLAKDAELHATTLQMALEKGHDEVVNLLMSHKAQTKATAETVIARGIDHICLVPAEAIDWLLDHKDLLQEARSLECEVIPDICAASQIGDWVNMIRVHGVRNSQVADFILKLAGMSAFPVYWILEPDNQAKARMGYDIVNEVDTVKENIVTYVIQNNQGGHQNEMKDNEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVH4</accession>
    <name>A0A8H5FVH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVH4"/>
    <dbReference type="OrthoDB" id="3168838at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="656" mass="72039" checksum="836B81CC979AE452" modified="2022-01-19" version="1">MGLFKRILSLGSKKSKKKRLEIHHTVPIDLPVDEIGVRSAGNDEDSEIAANLLLRSSSARYAVVAEMDYSSLPPLPHPIDNVLSIPSASTPDIPGTLVTRKGTYSVKVHQRQRHSTTDISGNSHLDPQITPRPRKCEQDDSEDAASRIMTLRRDPSVASLLDMYDEHGHLPSKAFSNSPTKEGRAQVKRSGSTLRQLLGETDEGPHSRDNSTSEGDISWAERYLAEAGSVASSVSSLVLQTPDNFDTHFPDARSLSHDIHDSTISSNYDLSSSLIENPAISSMEVELSICSEESPETVDRSYVSEAPYVSIEPKTPARRASQVFGFLTERRRSRAPEECYDRPLPELPSAFSSPSDVGSTEGPLRSHFSSDHSSESIYENSPAIPIPLIQDTPQHYRSSAVSSMRPSIDAFVLDTPAPAPRAGPNDSCILSPTGLENTSDTLPSDLEPEDVQKARKVRVIMTAPTKVIVTSATPSTADIDNRPPTRLPKGPRSLRQQQQHHRRRRTSSHSKRPTLLDRSNSASSSATKDSFTPISSRSRKPHRVSSSGSSWTFAEAEEQLGKLDEKPRKSRRGDLKSILEKENNLGLSVKSEIPSTPMRTQSSRSSKLLRAAVDHSFFQPPSPASSTELSPVGKQIMADARKHRSSKVRKDSHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVK2</accession>
    <name>A0A8H5FVK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_010342</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVK2"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034964650" description="Autophagy-related protein 27" evidence="17">
        <location>
            <begin position="25"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="18">
        <location>
            <begin position="40"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="320"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5350756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="393" mass="43463" checksum="A18BDF6A81792D26" modified="2022-01-19" version="1">MSASMHFIVHLLLCLLLTLQHAAGAILKSPVEAQAAEQDQPCTFTIKAFKYDLCPLFHSLDAPFKIVKEEDTPPTITRKTYEIGLKSALKRDKTLPAESQCSDGTRICLIVSFTRPDRPSVPSQILQVIPIATTKDLTPKPKIGEKSHADDEHSPLLVTLHGGLYTNLRQKATFIFRCKPDSVEPSKPTIAWSFNGTHAFNWETQHACHEFVKPSPSTGDDETPDEPPDLPPADPDNDNESESGSGSGQPATATGHVSFLALLWCVVLVVLFLCTLSYLGVFSFRRTTRYLVRPLRTSSLGGPSASRLLRWAQQAGYTQENEYDDEYDYDNDDDGPGRSGSQFDSAFMNGEEIPLTPSPRKGTFGSEITTYGTGKAWGERERERERSSDHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXU2</accession>
    <name>A0A8H5FXU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXU2"/>
    <dbReference type="OrthoDB" id="3128010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="575" mass="63580" checksum="2459D704AC000329" modified="2022-01-19" version="1">MNSMNISISSRFSFMKSIERNPNPSRVVLDAVLYYVFHFLYLGHPSEMLARFWLAHDIAVGRVRDDTEDAGKSSGSRDRERELKAWKMLDDSLRESYRAIGVLAGLIAAAVSALFAIDQYTARASIRVLLLVSLTSSFVSAASCISFLSTVYLDPIIMKHHWMTSGLVYILVLSGPSAWLSIALWTLQAALLAIVWLAEGRTARALVTTMIALLLVLKFWSRLASVQFRVQDFLCELLGRKQGMNHRMVHVNKNTIASRNQYLQSLEKILDIDSSITRRDAEFNEKTGGDDDSGTSATSYRMRPPRPPPRPFDPGYGSVVIMSESMPPPRRPPVSLAQPLRPPSFDPGYESVDIMPKSMPPPRRIPPPPLRPPSFDPGYEFVDIMPKSMPPPRESWYRPSTSVSPPTAPNIGPVAEPAVKDFLERMPSARRAPSPSIEDSQESMSEPPATPGGHGILPVKNPSAPAKKTPQSDRANKTASDTQNSKHRGDAPERTNQDNNARCKPSTHSSGSSTQRHNGFPVPPTATSNDRPVVDPVVMGFLERMPHAMVLAPMSSTEDLDLKRVVGRRHSIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYD0</accession>
    <name>A0A8H5FYD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYD0"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034971297" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="66026" checksum="766870891EA9019C" modified="2022-01-19" version="1">MTMIPHTPRFIPTCIALLLSSRVAFGDGISTRPSACRKLPEDEDWPSLATWDAFNASVDGRLIRTVPIGSPCHNPTFDADQCQFVQDNWHEESLHLPSSSSIMAPFFANGSCDPFTPPDGQCIIGSYVQYTVNVSTKAQVVKTLDFAREQNIRFVVRNTGHDYMGKSTGKGGLAIWTHYLQDMEWIADYDSEAAAYRGPAIRASAGVYVEQLYDFAAKNGRVVVGGDCPTVGFAGGYIQGAGHSVLSSVYGLAADSALEYDVITTDGRFLTASPAQNSDLYWAFSGGGGGTYGIVWTVTVKANPDLPVTIANLTFTDAGISQDAYWEAIAAYSTFTLAFADAGGYLVALYSQSSFQGAPFFMPNKTIDEVNALTSTLLTRLDQLGVNYTYQINSFPGFRDAYANIPSFQGILIGTDTFGGRLLPRELFTEISLPKTIQVLRNIAAAGALAYDVSLKATVKNEDAPPNAVLPAWREAGKLLITLLPWNDTATPEEMLAIRNQITNVIDPPLRQLAPNSGTYLNEANSDEPDWQHAFYGKNYGRLLEIKNKYDPDQMLYGSTAVGGDRWAEDEDGRLCRVEAQQKIRKPMDDLSFRRQILQVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZ10</accession>
    <name>A0A8H5FZ10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZ10"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="5">
        <location>
            <begin position="219"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5354461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="451" mass="50685" checksum="A683EE6F3206F07D" modified="2022-01-19" version="1">MRTALVRAKRKDLPENMIQCADQAVIIELLPRGKGVAQHAKVEVAVSWLPTSLQLRLTQSDFNWVRVSPRFQIQISMGAALSVIVPAAVAAIGSFVRHLTSGQPAQNPAMGAIEDHHREAEAEREKREVAERQKMEAERRANEEAEYARMARETSEKERIAREEAEEKLRKAEDAARDAIAEAEKAKDMLKKGPGIQPVSWPTPKEYVRMLKARQYQEGKFHFAVAGLSGSGKSSLVNAFRGILDRNMKAAATGITETTSVIGRYPDPNPERPFIWYDIPGAGTLKTPDWEYFNQQGLYIFDGIIILTDNRFTATDIAILRNCARWNIPSFIVRSKSDQHIQNLEKELKEAIEEEAADDEECRRQLEGVRSAALKEYTTMTQRSVKGNLLAADLQDQRVYLVSSAAVRSLIRGSARKDLRYLDEADLIMDILKATKERRFPTGSQRSPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0K2</accession>
    <name>A0A8H5G0K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0K2"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="114"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5355528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="398" mass="46675" checksum="ECA2B1435ACC10E6" modified="2022-01-19" version="1">MDIRPLLQINCDKLLAQYRSNLKTVLELQTTLIDDVLPSVVDELNLGKQQMEWAREWLEDTQAIFQMLRREKFTRAFAMESIRKNIAWRSNCLWPPKPVVPTGKQQLHCLPDVRDPLGRPILVIEATAFKESSEIHQQQNFLIQIMEQFRLYLKMLNKSSEAYSPSLQYIVLLDLKEVTMKTISYDLLSWFSNELSPRFPGMLAAVFIVNFSWTHSQMWNFARRLIPARARSRVFFPSQEDLVKYFTPSSLPKDYGGLLPPLSLLDNPLPLAHPDDIQCEPTSPDTVCEDEQKEMPAPSTPSSPRYLLSPTNLLNPFFGYPVTTSQHSKSPSLQHGRRRKRDLFYTLLKLFWRRWNRPITAFFWLVAYMIAIRIWCRRWILYSPAAWKLLNAMWMTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1I3</accession>
    <name>A0A8H5G1I3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1I3"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034781368" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="59182" checksum="0FC36B17DB1C1358" modified="2022-01-19" version="1">MAPITTNAVFFSTILACFTAVYSAPTLLSRPSHQSGLHLARAAGADVVKQNAITAQGLNAQFASLSESDSCQDGQTACVSKGFAQCVGSKWQVQPCSGGLQCFALPLVNSEGTSLTCDTAEDAAARFQNAGVTGGVDGSGSTSGSSSNSTGATASSSSDAGEATSTSTSSSTGTAKGKGKGKGSGKANSSSTATSPAPTGTQFITGQCTSDADCASGCCGFNSGKCAGPVIAQERDGGCGFGDPKPNNRAAQAIQGPNAEAAPGVDNSASNGDGNGGANTANGSGDDDGDNDDGMDCGDDNSGDDNGSSNNGNSAGQGSSPETASTVASQTSASASASQIASAPAASESVTVSSDASSSTIASASEITASISAPNRATLPSGSAVDASSASVPPSTTIFLSVAGSSSASASPSPNQANRFQYRRQSNVQLTTESALTSGAATASASSSSASVSASASSLFGSASVSASDAIPTGSATASGINNAGDTTGVATGAGSIQTVTTTVFIAVPGLSVTATGAVSQATGEAEAGATGPVVSGVATGISTGVAASAPSDAASASIPVSASVGSLATDATAISASSSVVASTASASAADTTPTSASQGGFVFSTQTARPTFSFGQRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G381</accession>
    <name>A0A8H5G381_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G381"/>
    <dbReference type="OrthoDB" id="3013353at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55307" checksum="22E01E554CF9E7E1" modified="2022-01-19" version="1">MNQSALPGWLFVDDTDARLHYSPAGKWQLSNGSTPQSGNETLDNGDVTWGGGKIWNNTVHGTTSDGGNVTFVFNGTGYSVYGSYLFPGPSPKGRISCFLDGNPVADYFTDWPKDRDPDTMLGNIVFTCGSPTSQGEHELVINVDSLVNSSFYLDYILYEPISAGLEGEDAEEVMMMIGNPLTSLFDESSEHHIVEFSVGWSVGSPNNDVVNVVTRTPGASVTVDFNGTSIQLYGDLGVGSNLSNSAIYQLDDQPEQSFPLVPPFDGYDVFLVRQFLNLSGLSPTQEHRLVVSHNGSEEGMALSLDFFAVNRVFSGTVVPLTHSSPSPSAPASVTTGKNHLNAGELGGIIGGAVVLLVLCGIGTWLWLTSRRKARNKRLSLDPTPFVRPVVTMPDINPYEMETQMISPSDTIACNPYKRSRTRSSIRSPPIQTSSSEGDDIVNQLRWGNLKLQQRLAVHMGGNQGAESPGEPDFEAVTVERPQLVIHADSGWRIERRRAVQEVPPTYTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G549</accession>
    <name>A0A8H5G549_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G549"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="320" mass="36078" checksum="B6937ECC49A170D6" modified="2022-01-19" version="1">MSLLTRLFYKKKEEDYETILSELAQDIQKRQVKLSGIRLRERRATLAVTLYTLVAWVGYVILWYMNILPESGRGNMQMAKAIKGFPVIIGPIIILFIRRIVQIWYTRKGDAEERTLQNLLKQQRAKIEEVKKKTNYYSTRELLQRYDEPSPSNSPLRQRSVPPQPQPSTPQQLNYLATSSPAPQLTPPRKQWFDKLADVVLGDDDQSARYALICEKCFSHNGLVKESVWEDTQYVCPKCQHFNPTQRAKKQRASGLISSAAPGTPASATSSGIKKRSPASAIPGSRLASIVPTSPDSSPEKSETTGDETTGDESMMDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G859</accession>
    <name>A0A8H5G859_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G859"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034899448" description="Laccase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="161"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="399"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5360031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60338" checksum="319DBEB370858A77" modified="2022-01-19" version="1">MVLSASFIFVALALSAFTSAADLNYVFNVDNSVVSPDGFDRRGIIVNGIYPGTLIQAQKNDVLHITTNNNLTDSTMRRSLTIHWHGLFQMKTASEDGPAFVNQCPIAPQHSYTYDIPLNGQSGTFWYHSHLSSQYVDGLRGPLVVYDDEDPHLSLYDVDDENTVITLADWYHLPGIGIEEKFLNEAPFHEPIPDAGLINGKGRYNGGPQVPWARINVEKGKRYRFRVINISAYSAFTFSVDNHDLKIIEADGISHEPVTVGGFEILVAQRYSAVLEANQPVDNYWISAPMTLQHSSDNDNLDTDNVFAVLHYVGAPDSDPKGKPKNLATVTTATSSANVVDVAAKGGLKLLDESDLHPVFNPGAPGGSGPADRVIDLNFHRDSDSGELEWTINGIKYESPDLPTLLNIMANNFSTESQFSTSEHTFVLNRDEVVELQIHGSADGHKHPFHLHGHAFSVVQAMTGGPNFVNPPQRDVVGVGGSTVIIRFKTDNPGPWFLHCHIDWHLVAGLAVVFAEAPNDQRTGPQSQIIKQEWLDLCPTYQALPADLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB65</accession>
    <name>A0A8H5GB65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB65"/>
    <dbReference type="OrthoDB" id="3059495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34559" checksum="F48B034A334C5893" modified="2022-01-19" version="1">MYLLYSPELSIVKQIPSMYKSLFNLGGHSLIATLIVAALRRELKTSLSVANFKHPTVKDTAAFIDTEEGRPSEGFMSLAETVGASATITIRNELSGSAVFLFPEATGFASVYSSAFDHIPRKTAAFGDQNWGQTDTTESITSIVTSLIPAIRAVQPKGPYFLSGWSFGGYLALEAALQLEAAGESAGIVIMFDSSVYDREIGKERWYSELDPLLAIVEDKARWLTQFMKCNRMINEYKLRPGCFEGRAVLVRAERGRDPGEEHPPPVEAYNGWRKILPQIEVIGIDSTHRAMFDQANGPEMGKIIAGLLNEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE12</accession>
    <name>A0A8H5GE12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE12"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58192" checksum="F25347ED0EED043A" modified="2022-01-19" version="1">MLKLSLSRRIAVSPCVLPCLARLRCLATAAQKLPDTGFAGKAEGDIGSFFSSLGADAVDLPPRFMGLKRELWNENLVDAWRDVLKELEGRTDEIISKGNQIIPQISYADLSRGLSEEQERQVRKTGVIIVKGAVPKEEALVWKQAIRDYAVENKERVKGTKQVLTLDFLLLMTPVAFWNIGFPADNIQVYEFYNTKSQVLARTHPSILDTQRKLLRLWKASDPSTEISLNTPISYFDRLRIRHPGDQTFTLGPHIDGGSIERWEDPGYRSCFQKILEGRWREHNPFDASPRIHAKQDLYNAPNQCSIFRPWQGWTALSSTGPNEGTLRVLPMLALSTAYIMLRPFFRPKSLQSTSGWSSSTSLKPEDWELDLSSTKFPGAAMGKGLEPSEKMHFHLKLDKTMVSIPKVEPGDQVYWHCDLVHAVESQHEGKGDSSVLYIPAVPLTTYNANYLRHQRNNFVSGHPAPDFPGGVGESNNTGRGSRNDIKTRDGLQAFGFEPFEVKGSDNPGFVEKANAILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GG90</accession>
    <name>A0A8H5GG90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GG90"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5364438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="15758" checksum="12C64BC4565933AA" modified="2022-01-19" version="1">MTIGDFSAQALISNGEMKVGVIGCPNLPLNGEGKKGVDAEAPKPTRVHISAGSPSTSFIFPSSSFTFLEFVESVHSSHSTASRIADTLRTTSFQVNNPIRMDSQVKYCVLARRVCYSQFPSSSSNPPNQNQNTSLVLLYLRSQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIJ1</accession>
    <name>A0A8H5GIJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIJ1"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="631" mass="71731" checksum="0390CC28CFDB9AE5" modified="2022-01-19" version="1">MSSDVLTEEFEVLESIYPTELSKTSERDIQIDVEPENLPEGEETLKLKLHVHYTPEYPDALPDMSLDLLEGEFEEAETIHLLQELTKAGEENLGMAMTFTLVSHLREQLSELVLSRAERGKKAEMEKERLAIEEEEARTRGTPVTVESFKAWKIKFDAEQAAKKAQEEDQLLKGLTPKEREEHKRVGTRFSGRQLFERNRNLEEDTLMEEGTVSVDISQYERTRNDEEEDADVVTFSDIPQNDLFRRCKQEEEDAILPNSSNPYGLKKLGVGPLDSEKSSQQNDTRIHSPHNRKESSREYNETPRRRSSPGNRLRQPDDKVNTDDVEVLERSFLGVPRVGHSPQRPRSEKLVEVFRKITSFSSQIVQDTLTLNQEERKLQTYNDISTTLSRISESAASAVAPPLAEIILTRVQSKERLEEGYHALGAAWDQVFDIFVTEVAQTIEEKLEAALRTIKNEANDLANDLVASDSKSGLKRKFGDPISDSDLGRSYRSDSSRDGKRRKITADGSYSPVDTRENINDLSSLEEILQRMKSKIDQQNNSLQILARENQELKGQLQAHGGGASTSDSSIPRAPKEMLNAPTGHSSNENEGKSYEGSRPRYSRDREGDRRLGNRESRSREGYDAKRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIJ9</accession>
    <name>A0A8H5GIJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIJ9"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="87"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="448" mass="51364" checksum="0F5384BB68533301" modified="2022-01-19" version="1">MIELRSSKDPAPGARSPIATRWREEGTANLGPSQLRWAPVIQLPDSLPAYKARRRLTKSFYRTLRVSRGLDYNYYFSSPRSRQKPYIFFIHGFPSTSYDWHHQVSFFKEKGYGIIVPDMLGYGGTSKPTDPKFYRMDAIAHDLIDILDVENISKAIFVGHDWGCAILSRLLLLHPSRLHAAAFLSVGYLPPDPNFDYEKSLRDSKAAFGYELLGYFSFFESEEGSSISMDNLDTFLNILYPEDPKTWITDMGPIDAIRDSISSGKVLPSASWLSSEVCLYSHGYVYWLSTSTQDKAQQKKIIQDGGLAAPTCYYKAKVRGVHNGEDQALPPTPFPLNVPVFYGGAAEDFICLTPVYKQILDQIYSGSQEGERYTYREFKANHWLMMQIPDEVNKELTGWIQRIEAFEQKFWRSFYMYDITLWTKILFTGALEIQVLIMDVYNGRHFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIL4</accession>
    <name>A0A8H5GIL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIL4"/>
    <dbReference type="OrthoDB" id="3268858at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22957" checksum="9F0B3064147C947C" modified="2022-01-19" version="1">MEGSPKILELSGVGNSSILEAAGVQSVLELPSVGENLVDHAHSWANAFTNISLTKDVLNQNPIFAQQQLELWFLLCCAKISWYRSAIERLQPNPAKRPYQRGREKPTILRDSVLQWKPANPPGFLASSQISHLSFFIGLQHLRKHRQASRAESRNSLFDGQDAQEPSASYNQIMDQSDDNDEANSADIELLKPDLGALGQMHLGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIQ6</accession>
    <name>A0A8H5GIQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIQ6"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5365773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="14818" checksum="D328084831779EE0" modified="2022-01-19" version="1">MRSKFKDEHPFEKRKAEAERIRQKYPDRIPVICEKADKTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPPTAALMSAIYEEHKDEDNFLYVSYSGENTFGHEGWLELPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKF9</accession>
    <name>A0A8H5GKF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKF9"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="355" mass="37667" checksum="66753FFB67AF3827" modified="2022-01-19" version="1">MDNSAQNFNVSVDDFDSVLSYPDQSLWTTPDPSSSSFNAAGSPWLMGTFHKTETVNASVSFNFTGPAVFVYGQSGPDYGSYEVQLDSSTVTRSAYSSSNGSTPHLLYEASNLTYGAHQLTLRNLGAQDGDAGGNAFLFDFLRFTVQLAPAGATVSNTTLQEDDPALHYSGTWGNNTSGNFNGGGTSFTQEDGASLSFSFNGSAIYIFGDKKNDHGLYSVVLDNGTAEIYDDVSGCGGAFGMTCEQQQPTLKYFASNLAEGQHTLTLTNMAGVNHSFFDLDSIVLTIPSVYAPRQLENSTSGSSSSSSNSSGSTSPSSNDDNSAATLFTSLNPLMLLVLTVVFLLRPTLSSSPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNZ2</accession>
    <name>A0A8H5GNZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_002452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNZ2"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF44">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5368521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="863" mass="97178" checksum="E644CE0F227A80E4" modified="2022-01-19" version="1">MAYQQRPGPDPYYSQPHHNNYGNYNSYSSGNMGGAPDYPPSHHDHDMSWETKSYTSTHAGSQVHLNPYEMNQVNHPPVPAMPYGAPDYPPMQQRPGMYHNQSSAGYSVAREKMMKRRSVRQVELFQGNLVLDVPVPSHIVPSGKQGQEEMTKMRYTAATCDPDDFMAKRYSLRQYLWNRQTELFIVMTMYNEDEILFCKTMNAVIKNIAHLCSRDRSKMWGPEGWKKVVVCVVSDGRSKINKRTLQVLSLMGCYQEGIAKDSVGGKDVTAHIFEYTSNVIVTDTGEVSQGSCPVQIVFCLKEQNKKKLNSHRWFFNAFGPLIRPNVCVLLDVGTKPTGTSIYELWKCFDKHSNVGGACGEICVDTGRGCSLLLTSPLAASQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYKALQNGPDGKGPLASYFKGETMHAGGANGAGLFERNMYLAEDRILCFEIVTKKREGWVLKYVKSAKAATDVPTTVPEFISQRRRWLNGSLFASVHATVFWFRIWTSGQNFFRKIILTFEFIYNAVQLLFTWTSLANYYLAFFFLISSATSDPKSDAFSFMAQGAGKDVFEVFLKLYIGIIFVVLVCSLGNRPQGSKWTYTLAIFLFGLCSIITVYCAAYTVWLAVPHSSAGWSNFGQLLKDTPALQDIVVALAATYGLYFICSFMHFEPWHMFTSFLQYTFFMPSYVNILMMYAMCNLHDVTWGTKGDNGSSKDLGGAKKVKGDDGKEMMEVEIPTAKEDVEQLWQAAKSSLKIKPPEEKEHRDAATKQADHDRNSRTNVVLAWVGTNMLMILVFTSKAFTDFVQNHIINTSNSNFNPYLSFLFIALAGLSAIRFVGSALYLVFRLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ94</accession>
    <name>A0A8H5GQ94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ94"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="519" mass="54018" checksum="38D695196131980D" modified="2022-01-19" version="1">MGRRKIEIQPITHERNRSVTFLKSTYLFLSFSVFFTTLHDVVIIVLQRKNGLFKKAYELGVLCSIDVAVIIFEEKPGHHVKLYEYCSSDISEIVNRRLRHDGEKDTLGPAHFSGSANKTEDAGDGDDDDGEDEEDTHQRGTKRRIDGTRPSNLKFSLSFHLSFPGGDAHLTQTYPPHRGLHAIPLHNISQGSGGNAPSLPVSSDRSVLRSGGGGGSGASLQHHHSHPSQPSGNPNKKLRMAGGISVSTGSHRSSSDADPVSASSAGGSAAGGAGYGTYTSSPTSGYSTRGGGGGSQYNSVFPLSSSTPNLIPPTYDFRSGAPPGPGTGASTGSGQQRMGNYSSTPPTGLYGQSMNRSSNTNGSGTHGGDGGTSDIFSFLHDDAGPGNSRGSGTGGNSGGGGYSSSLSWPEGSSVPPGSNTSQSGSTNDNWLDFLSHSSHPGGGGGGSSRGGRRSIGNSMSWERNAGSGHRVDTVRIGSVTGRRSRLGSHSGGEEDDHDFGNNRSRSNGVGTEIKKEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR11</accession>
    <name>A0A8H5GR11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR11"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="21585" checksum="C56E074A66A7743E" modified="2022-01-19" version="1">MRIWLILWKNLSSNCETALNSSPSPSVPLTAPDEGESKKKLLYSDTFSQTARTWSNSSALASWLFPSGNDFARCSLESSMLKELVVMLTVRRSDSKESMTSATLPSTAHHIVGNTFPYTIQDWSDDISLASEHNIDGFALNIGTDPWQPDRVADAHQAALQSGLDFILGYVLPSLCFSYRCTGFTLPRSQIRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSC0</accession>
    <name>A0A8H5GSC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSC0"/>
    <dbReference type="OrthoDB" id="3229989at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="16115" checksum="78C3FEB0825F0137" modified="2022-01-19" version="1">MERFLASHSPEAVAHSQFCENYFGWDVDHSSFDEALVAGCASYRAIDRYLSGADLFILPRNRSELESILRRYCYDAIHNAISRSKATLETGGYSRVCHLAEESISQVLNTGDNTSVLLSLHCINSSNANNHQRPGHPNWPIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GST6</accession>
    <name>A0A8H5GST6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006898</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GST6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5370376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58631" checksum="3B420894C38B49C7" modified="2022-01-19" version="1">MVRTHFLRTMSNIFYDPILLAASFAALAVSFVGFQQIKWRQRTRGYPLPPNGLSTLPFIGNLHHLSPKSPWLKLTEFKNHFGSDLLYFHGLGNSVVVLNTMEAITDLFDKRGNTYSHRPVFTVVGELMALGQSMPLLPYGTEWRAHRKLAHVALNQNAVKVYHSAQEDLAVLLSKALVDKPENFFSHVRLAAQRIVMTVTYGLPVETADNEYITKAEETMEMIGKATVPGAYLADILPFLKHLPSWIPFQREAAEGKEMIDSFVTKPYEHVKREMNTNNAKPSLTRHLLSIDQEEMENYEHRVKWTTGAMYGAGGETTYSTVLIFMMLMAMHPDIQTRIQAEVDAVVGCDRLPVISDRSDMPYVAAVIKEVMRWHPVLPMSIARQTAKDDVYNGYFIPAGTTVIPNVWAVSLEPCAKYDPKSFNPDRFLDPEAKVTDPTTYAFGFGRRICPGKFLAENSLFVLISNIAYAFNISPPVNGIVEPKFGENLVSYPEPFDIQIKPRSKQKVDLINARVQQCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSU7</accession>
    <name>A0A8H5GSU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSU7"/>
    <dbReference type="OrthoDB" id="6118920at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22604" checksum="D6827A33F604756D" modified="2022-01-19" version="1">MSVETRCIYLVGPSSTGKTTLCRALAAKLKLDKASVISEVAREVLKSHNFTRDHVNLLRMQEAILEAHLKRESEVLGRTSAPLLLCDRSAIDPVAYAILGAKNDNDAEERKKILITSAAFQEALNRYRKSLFILFKPVEGWLVDDGVRSLDNKIGCAEVFETVLEEFDIKFLKMGPDMTDLSERVQFAVDAIQESFGIILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTD9</accession>
    <name>A0A8H5GTD9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTD9"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="585" mass="65015" checksum="D99A75E3022DC6CA" modified="2022-01-19" version="1">MPTCTAKASYKKIPGILELNDSHLQWTQDGKKAPSVRVPHSEAASLFCSKEGAAQVRLKLGLFADDNGHNFTFISPQAIAYSEREKFKKELTTIISRNRTAAENAAKPPVTAINASTLSTPKPSTVAPSPASSSRAASVSSDTGATPIILGNDPATDFRLRKTVLLGNPDLAALHRELVIGGQITEPEFWEGREHLLFAQVASEQQQKGKPGQLVDPRPETVEGGEVKIRITPQLVHDIFDEYPVVAKAYNDNVPKKLSEEEFWKRYFQSKLFNAHRASIRSSAAQHVVKDDPIFDKYLEKDDDELEPRRQRDVDIDLLLDLAATGEDHDVTGNQQDVTMQAGRQRGALPLIRKFNEHSERLLNSALGEGPSNKRRRIDLNEHEAIDLDDLHDPETSVGIALEMQDRQRYFEGRMANASSKDASQQAFDIKEVIRSTKVDLQQWATNLTQLKIERKHGDAALMDMTHNVAARLDVKSRRNDLPEGIFRQMRTCQTAANEFLRQFWTATYPPIVEGPALSTPAQRAARASKMIGYLAKTPEKVAAIVQTAHQQGIDAARVEVAMKPVLDAVERALAFQHNKKAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUG9</accession>
    <name>A0A8H5GUG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUG9"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="26972" checksum="5E6E763939A41438" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILLAWLQATGLSSVLSSDRPSDAEVSTVSPLSAEDTAAQTEAIMAARKKQADWDEKNDKAIGSIKLRLSPPVRQKTLRMTTAKAIWIFLKKTYGKPGVSAIYMDFKRATSIIIPNDANPSAAVELIRMHFDRVSAAGVPSDDSSATSITKVTNFLIVMFIISKLPPRYEYLINQYTQCSIKQIDGQSLDELQSEIVNIWDRLSAVKRKDGNPSFQQQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV00</accession>
    <name>A0A8H5GV00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV00"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000036">
        <property type="entry name" value="NADP-dependent oxidoreductase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5371310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="326" mass="36202" checksum="B31870106B6E4D44" modified="2022-01-19" version="1">MSFNEYITLNNGVKMPQIGLGTWQSAPGEVENAVDIALRAGYKHIDAAVIYGNQKEVAEGIKKSGIPRENIFLVSKLWNNSHRPELVEADLDNTLKELESSYLDLFLIHWPVPFQPGPELSALRPRNDSSGEMETIIDTDAPSIAETWKAMVKLLDTGKVKAIGVSNFTVRHLEILKAASDIIPAVNQIEAHPLLQQTDLIAYCKEKNIHLTAYSPLGQNITGRPPVIAHNIVKEVASASNATPAQVLIAWAAAQGFSVIPKSVTSDRIKSNFQQIKLSYEALKKITDLPKTEGRTRYNTPILYNPRWDINVFDEPEEKVASRSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVH5</accession>
    <name>A0A8H5GVH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVH5"/>
    <dbReference type="OrthoDB" id="2681076at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="53"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="145" mass="16685" checksum="6DE88098EA4CA3E9" modified="2022-01-19" version="1">MDLYKGLAIGATTSLTDYPEPSLHLSLKTSSVMHLLSTKDFKVKEFFMDILHYAILSHTWEQKEVTYQDVQNLNIMKSKAGFLKVLGACSCVRQYHFDWIWIDLCCINKESSTELSEALNSMYQYYEDAAVCYVYLSDILGAYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVP6</accession>
    <name>A0A8H5GVP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVP6"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="179"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5372181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="37947" checksum="584F7B775860EC67" modified="2022-01-19" version="1">MAIDTIQCLIARSDSNPPYKSIQFRGSPSGQIVQKTFTYSLDDLASNEVIIKVTDSGLCFTDIHMLKKDMCLGHEGVGIVQAIGSDCKNVKVGCCEKCKFCLGQDNHYCKGVEWYGSHNTDSGSLSTFTKRKEAWLFKIPASMPDTDAAPLMCGGASVWSPIIQNCHPFDRVGIIRIRGLGHLAIQTLRKMGCDIVVFSTDELKCEEALSLGANEFHSVRGLKKDYGELGIEPVDMMFISTSAKIPMGQLYPVMNPRSTIVLLTVDEGDLTLPYTQLVETGMTILGSSIAPRLEQILLLKITENARNEVHVMAETFPLTLEDVNEAVEKLKSGKMRYCGVLVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXN7</accession>
    <name>A0A8H5GXN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXN7"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41715" checksum="8032DC9EAC8E4465" modified="2022-01-19" version="1">MSQDEVRPILQASVHDVRYFSTLLRGVNFANRAVIKVTERGVVVIVEEARTLLGTSYIFSDVFNEWIYNPEIPSSQEQEQEPEQELSQDPDQTILHTSAFEIPLNAFLECLNIFGTAGTFNPAKSSGKVRWKRSGEDSDNENDNEGNNRNTGASHGSRRIEQYFGGAEKTTSMRMTYIGAGYPLTLIIAEDASGPTTRCEIPTSDLEEYLDIPFDNDRMVLKIILKSSWLRDALSELDPSCDKLTFIGHPSVKPDPNATTKQRMKAQLEGKPILRIQATGTFGTTEMDYPDDKEVLESFECEEPVKFSYRLPLIARTARALQSSVKTSLRIDDEGLLCLQFMMPSPNSRNPRSDNLTSNFIEFKCLALDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXR3</accession>
    <name>A0A8H5GXR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_001762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXR3"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="790"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5372914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127612" checksum="38AD99CA8170E732" modified="2022-01-19" version="1">MVIMVRIIIKGGVWKNTEDEVLKAAIAKYGKNQWQVPDPPHPLARISSLLVRKTPKQCKARWYEWLDPSIKKTEWSKTEDEKLLHLAKLMPTQWRTIAPIVGRTATQCLERYQKLLDEAEAKENEELGLTGPSDDIGPSADDVRRLRPGEIDPDPETKPARPDPIDMDEDEKEMLSEARARLANTQGKKAKRKARERQLEEARRLAVLQKKRELKAAGIMFTDNDLSMRHKTKKKGMDYNADIPFEKKAAPGFYDTSEEQARVAAPPVGQTLRRLENKRKPDEEEAERKKRQRKNASGKEGEHQTKFIAARDAQIQKLKEAESIGRRQKLMLPGAQVGEAELEDIVKIGMAGENAKALVNGGSDASGKLLSEYEGLENARMARTPRTAPQQDNVLTEARNLRNMTIAQTPLLGEENTPVHQGRDGGTGFEGATPRHQVAFTPNPLATPLRAEGDVSATPRGDGRPSATPLRTPMRDSLSINPDNYVQTGATPREQRSAKRALQASFMNLPKPENNFELLVPEDEDEDDVAQGKVSVEEDAAERDARLKRAQEEEQKRILARRSQVIRLGLPRPPNVDPVDLLEQLSLEEGDGDDLDEARKLVNLELASLLQHDSIEHPIPGTSRPGSSKSTYEMPDDEAIDIAKNLIHYELASLTGYPQAPPEQVRQGLLALSSVDDIDDKASWAFVRPSLVFNPHTRTWVEPERLSAADRVAGYSAQLNETRDQMTQDAHKVAKAEKKLGVALGGYQARSQALSKRITDAFAELQKTQHEYQSFSRLQANEMAVGPRRVAALKEEVEKLEHRERLLQERYSELDAERRESDSRVAVLEEKMMAEAEALNEAHLAAMEGVEADEHMIIPANLINFVCLKAVNMLANASTTTVFLDEPTASPTSNTVHGDNIPVGAIAGGTAGGVILALIVVWFWKVWGKSIKRTEAKKKNEADALRTMKQNTLQNTYSKPRARTRSFSPLFWPPSETKVKFATPNQGESSFETRKVSPDTFLTRQVLLKPSRPKPLRPLDPPSEPKPTLPVTAPATVPGKLKLPPPVKLPHKPSATTISSASVYSAESGEDYRRSKPSTFHSIVAALGNFSSDAVQNATRTSQIGNRLSVASNWSFFSRGTRGTQNRLSQATSASAYSQSDAQSSVVGVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXW5</accession>
    <name>A0A8H5GXW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXW5"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33156" checksum="280CA6AEB96D0BFC" modified="2022-01-19" version="1">MRSNNSCTKQQQFQQQQAQLQQQQQQQQQQQSRGLALPASNPYLPKPSTGLSLPGPSPLSNSYQPPTAQQAFPQTTHTQSQSQTPPSSAPSPSNAVAGPSTPPASAATPAPLTLEQQHITAVEGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIVQKLGFDAKFSEFKIQNIVGSCDVKFPIRLEGLAYSHGQFSSYEPELFPGLIYRMIKPKVVLLIFVSGKIVLTGAKVREEIYTAFNTIYTVLCEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXZ4</accession>
    <name>A0A8H5GXZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXZ4"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="220" mass="22739" checksum="CC8562CAE1CE2195" modified="2022-01-19" version="1">MPCLDVEEHDGKPKTTTQSTVIIVQTSLSIQKSKQKPQKGTSYAALGLIHDLNPTESGGTEISIDIMGNTDSSSGLIGVCGETATVPSSFNLSCASETSTGSSFRSRTGTSNASAGPRANSTKTTSIPAGYGKIIRDENGHIIDVQLAEEPEGEDSTPASVGDVDMEQLSPELDESIREKWTDLGGKNRALGGTDSTVVKAIPGQEDAGAGTLRGATPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY89</accession>
    <name>A0A8H5GY89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY89"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5373169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="233" mass="26192" checksum="8EE966648974B0B7" modified="2022-01-19" version="1">MYSQNYNSGYAPAPGYAPSTHGSLHSHGSVHSTHSTYSHRPRHSSNYSSQSYSSGAPAGVDPTLWSYFSNVDRDHSGTITVQELQQALVNGDWSHFDLDTVKMLMGIFDVDRSGTINYNEFAGLWKYVSDWQNVFRHFDRDRSGTIEGHELSEALQSFGYKLSPHLLRMIEQKYASAPTSTYGPPPGINFDRFVRACVAVKTLTEAFQRADVNRSGWVQFNYEQFMSIVLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZB6</accession>
    <name>A0A8H5GZB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZB6"/>
    <dbReference type="OrthoDB" id="2973648at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="132" mass="13836" checksum="2A01F49D7BFBD99C" modified="2022-01-19" version="1">MLPRPSTPLATVAAASVNALAVPVVAPDVFVPRIITPNQDTVWVKGATVEVTWDTSDAPAVISKGSAVGLNKADIPIDRYSKPGNFLAEDFDLRAGSVSIVVPSDIDAGDDHSITLFSDSSNRGEQFSIIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H100</accession>
    <name>A0A8H5H100_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H100"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="408"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1203" mass="136897" checksum="3B5E3E92B43DCD34" modified="2022-01-19" version="1">MDVFMSNIPFYTGLHELTRLLSPIFHDSTYTDRFAQSGLPLNFHVRLLKNNRHISRTGPHGGRGFITLPTVDVAEYFLAEYGERPQGNPPKVFAINARNVRFSRANKPAPKDIIERTQRRPYEDPSIAEERESRDAVLKSNSVIVKTVQFGWDCRDDVYSVEWEYSTTSALNFDHDRREIRISIPYQYQGSLIIAIRPSQITEMSAHIYRSEPVLFFSLSAHPTFLLTGVAQKQQRIPYLPFNDHERLVTYTSLAMRLVCASTQDLHRFRSLCLAAQMRAVQDWEYPIVKKNIFSATSIERLNSLLRKLNWRVAFQLEMIIRRTYVDVQEALQLIPAIIKLVELRGKEYVAAFLQHLGTQLAQGYFDNSQGTISDWFIACEHEYATYKRPSPIIPSEGSLFQSLHVVVTPTTMYLEGPFPERSNRVIRSYLEDQESFLRVSFVDEDGLQFRFDRDVDGPAFIRLRVGKIFHEGLTIAGRTFRFLAYSQSALKEHAVWFVKPFRDARTRQVVDAASIIRSLGDFSTSSDLVHCPARYGARISQAFTATDTTKVEVEEIINVPDISTADGKYDFTDGVGMMSKELAREIWAGLKPSKKRRNKTKPPAFQIRFMGSKGMLSIDYKLKGLTICLRPSMIKFEGAESRTIEIARAFDRPGKYYLNRPLITLLEGLGVSYEVFEGYQDRAVRQIRQSTYSLESAARLLEHFGLGNAFRLTSILLSLSRLGINDMPQDSFYQTMIKYAVHHVLRDLKNHARIPIDGAWTLVGVADVHKYLEAGEIFACIQPVQGPIVYLEGDVLISRSPTIHPGDVQIARAIGRPPPDTCFAHEPLKNTVVFSVKGERPLCSVLGGGDLDGDVYNLIPLDKFPEFRPKRTCQGASYTAAPRKMLDRPCTMDDVADFFMDYINNDVLGIIGSSWLTIADQAKLGIFHPDCLTLAQLHSDAVDYPKSGQSVALDRIPRPLLKMKPDYQAPETINPDTTTRFYPSTRAVGRLFRRIDLPQLHTEVHVTRAARRQIREKGHLRQTRGVNALAESLTALEIRDDPTAEAVNYRVFQYLSDEDMDTMDHEREELFVARLFSQYSSELQTILAVNTLGHARAALLTEEEAMVGTIAQKSSQPRKRNNQMAKLREATDTLVRGYRSELAGEDELVSLRLVRAWLAWKLGLKERAKMDAIGAQSFCWIALGAIFEVIREIEDQEDPYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1J2</accession>
    <name>A0A8H5H1J2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1J2"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="914" mass="101220" checksum="8CD1CF723EFEFB8D" modified="2022-01-19" version="1">MSVIIAHRPKKMSIELVGHPSLASPRVGKHYSYRRSSPAAIGSSESPSSYPPRSSYRGPEAETRQNRMAPRPLPTIPARPLRPEASYRERELPHPYSYNAERDGAHLKSGNSHNRNMSCGATDEEKRQRRRGVVEPVTLLGAGGGESTTSSETRSGKKEASARVQLNSLTISPNLDAMLEHEEKLKRLKDRTSVEMKTSVSDVPEGLPLPPRKRTSLRTRGQSVTAEAEEEVAVGENPYLNPCPPLMTAGSRRDMQPTHDDDADDNSSFLIVVDDDDSDDCNDAHRISISSTAYPGSSESPNSITPIPMSTSPKPPRPSSKVPEHLTRRAMSTNPDGRLQPNERAELVRRTRKLAQLFGRTPGAATLDPSRGHRAAFSIADQSIFSSTSQHETIRISASSRRHSTPLSPDDLKSFRLPSPSSDSPNGASNKSFIDLSDEEEERSMLGTSRMVEDDSISHSESIVLDEPPLSDSDDDDGAERRRNREKLAKLHRFLGSRVPPDLVLGRDCGHESDLPPIAIIPLDIDLDNMNFHHQSEDEARKAWLKRRRSSSAAAFPHWSDDHDRLKEDLGDEEKKINVRRAHKMEQVFGVAPPQTLYHTRQGPSPSIPRPELILRSGSGSLDVLNVNQSSYIQKPSRVASGSGSGANSRSASLSRKRGKKEKRPGTSDSDNSTHQLLDKNEQLELDYGTISATGYGSTSSGAGRRPRAGSLVYSHYQHSLNSLNDILDRDDKESLAELHEYLNNANAELEDRDDHVDAERDSSPVSPIEFRDSNPNFKHYKDYTSPKERDLKDKRLSNASSIKSERRRSLPSRISTLSAGSVGTVGSLPSLGPDDVGAATPSPSVHTFQQRRRRAAKLTQFFGVNYRDLIKDVLDSIENGLERERKRGTMPEEEVEDLLQKLRTLKSKRNGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1W7</accession>
    <name>A0A8H5H1W7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1W7"/>
    <dbReference type="OrthoDB" id="3262732at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="10959" checksum="2772E5DF3F0F91CA" modified="2022-01-19" version="1">MTALTLEQKKQRYSRDLAEHTLRQFNSLRLDEASRSGLARERTATHSSERHLPSRNAGKHHDIDAGASDPADITPRREKQANGNRLWNTVTRAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LH60</accession>
    <name>A0A8H5LH60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LH60"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748674" description="Glyoxal oxidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="462"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5357290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="68548" checksum="270506D8C90515FF" modified="2022-01-19" version="1">MDSTLFSLAIFSSFIVGGVVGQSLAEAPGQPTHSGTTGQFEIVGDSLVSAQQIFLGTVDKVYVIDKVENNPTRINDHPAWAAEYSVSTNKARAMDVRTNTFCAGGNVLGNGTWVNVGGNQPITFGGLNWDDPNSNGPYNDPDGRKSIRLLNPCDDESCNWSEAERELHTGRWYPTVEILEDGTAIIIGGAANGGYVNDAGQDVPTYEFFPSRGDPVHLPILDRTLPANLYPLTWLLPSGQLLVQSNWETTLLDYHTNEETPLDNMPDAVRVYPASAGTIMLGLTPANNWTATIMFCGGTNLQPDQWYGTQVVKIPAETSCVKISPDVSPSYTHDDPLPVGRSMANFIHLPNGKVFCLNGVETGTAGYGNDTWAIGESYGDNPVLQPVVYDPAAPKGQRWSSDGLSPSTIGRLYHSTALLLPDGSVFVSGSNPNSDYNVGPDVKYFTEYRVERFYPSYYNERRPEPKGIPQKIGYGGSYFDLTLSQDDLSGDSNNLNKTTVVIIRTGFSTHAMNMGQRYVQLDSSYTGYANGTGVLHVSQLPPNPAVLVPGPALLFVVVDGVPSVGVEVMIGNGQLGAPEVQQTLALPSSSMESGTSSQQGHEESADGKNSAIRPSNSMTALYVFGLISLFRVIRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIS2</accession>
    <name>A0A8H5LIS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_007721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIS2"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034178445" description="Glucanase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5358659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="460" mass="48469" checksum="3338453DF91EA6F6" modified="2022-01-19" version="1">MFPSASLVAFTFLAVAYGQGVGTNQAETHPPLTWQECTSSGCSSQASSIVLDANWRWTHTDGGFTNCYTGNEWDSSLCPDGDTCAQNCVLDGADYSGTYGITSSSDSLTLKFVTQGQQKNVGSRVYLMAPGSDSEYQTFNALNKEFTFDVDVSQLPCGLNGALYFVEMDADGGMARFSSNTAGAKYGTGYCDAQCPHDLKWIDGTGNVEGWTPSDNDPNSGTGNLGTCCNEMDIWEANSISSAVTPHPCTVEGQTSCTGSDCSAPGSTGGVCDQAGCDFNSFRMGVEDFYGPGKTVDTNSPFTVVTQFITADNSTTGTLSAIRRIYVQNGQIIQQSDSAVDGVTGNEITDDFCSAQKEAFGDVNTFGQKGGMAGMGQAFSRNGMALVMSIWDDHAAQMLWLDSNYPLDKDASAPGVARGTCGTDSGQPDDVESASANAQVKFSNIKFGDIGTTFTASKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK82</accession>
    <name>A0A8H5LK82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK82"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034609511" description="Six-hairpin glycosidase-like protein" evidence="1">
        <location>
            <begin position="42"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="83840" checksum="7C2D10997AE09531" modified="2022-01-19" version="1">MTLITASELMTMFAQGTSCPSILLLLLSSLTFLIHSKPCNAAIDRHSIVSRYNPSRNASSMTTPMQIGNGFFAFGADVTGLQTFQPFAIMSSWGWKNDSLPSGKTMEDVENYHGVSWLNHGRPVEYDFGSNDPELEQWLTANPNRVNLGRIGFLFRDGEGQVLDVTESDLTEIKQYLDLWTGKMSSSFVLDGQVVKVNVTCAQESDTVAVSVQSALLAAGRIGFFLDFPWNDGSKKFSAPFVGSFNLTSNHTTALSTFSMDSGRGDIKAQIIHRLVNNAFLTSLGGDDFAITRDTPHTHRYTILSNSSGGSDSFAFTATFTPEQNPPSTIPSAADVEDSSLRAWQDYWTGSGFVDVFTGSTDARADELQRRIILSRYLMRVNEAGDSPPQESGLVNDGWYGKFHMEMFFWHSAHWALWSNWDILSRSAPSTYSRFLPSSIHRAQVQQGFASGARWPKMTDPTTPGRSSPGQINNLLIWEQPHPLMFAMYELRSVSGLGDDGGEKREEVLQKWSSIVRETANWMASFAWFNSSTGVYDLGPPMYVVSEDTSPNDTVNPSFELAYWKLGLGFAETWVEELGEEVPQVWKDVREGLAKLPLEQIDNETVYRVYEGLEDDFWTDPAYTNDHPALVGLHGWLPPTEDVDLEIAKTTAEKVWGSWNISNCWGWDFPMLAMSAARNNETSKAIEWLLHPLFQFDDVGMPIGGVRVPTPYFPGSGSLLYSIAMMAEGWDGSEGLAPGFPKGWNVQVEGMSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLG9</accession>
    <name>A0A8H5LLG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLG9"/>
    <dbReference type="OrthoDB" id="3068307at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="461" mass="49221" checksum="CDC1FCC536089C7D" modified="2022-01-19" version="1">MDDDTNSKKIVGLTQSQIPSSTPSVVLATLDPPGVTIAPNPGPPGETAPISEGLSSALDPAPTTLSPEAPGLTSTSLTKRPAHIPRPPSSRPPEQNADTRSSVPPGAENTAISNNQGPAEDTSTKNQGNSLSTGLPSTSTSAAIDNESSSSPRIASDRSSVTHLSLPVNTHSETQSESLPTTETSTTPTSAIPNPTSIGHGGNLASPRLDIILPVVLCALLVLVIILIIILRRRYLIRTRKISMSTRDSGVTEGLRDFTVQPYILKPEYPVFQSDHSGPSFLGESNQNSASQNSVNSTTPRRNRNRNLFAWVPWHARPNDLEQARPYMLKEDISPAPNNDSASSGTDSSLDTQLQKRPFSATPSFLPGTPPSIRTRASSDHSIVRSAGANSQTGTVATARQIRLLEEADGMREQLAGYQGDILVSAERMNRIVAHIQRLEMELNSDWARGLTDDPPPMYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMK9</accession>
    <name>A0A8H5LMK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMK9"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="228" mass="24705" checksum="3204B1C2FFF3E844" modified="2022-01-19" version="1">MTSPHDQIVNGLFKLLVKHGQGDYIGESISQLDHSLQAADLATIANAADTTVAAALLHDCGQIIPPVVINRQLKIHPEKDSEDQNVEYMLLPSGQSVGRHGHDTIGAAYLSSPGFPLITCQLVHDHVIAKRYLTAVEKGYYDALSEASKASLKFQGGPFTPDEIISFEKDPLFSEKVAMRRFDDAAKMVGKKVPGLEAYRTVLIRVLSVDLEKEGGGDAEGGKQGEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR32</accession>
    <name>A0A8H5LR32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR32"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="449" mass="48779" checksum="FACE853DC10A4F8A" modified="2022-01-19" version="1">MSQPPPTQAKILIVGAGPTGLATAVSLIKHGIAVHDIVVVDSVLSGQNTSRAVVIHSATIEALESIGCFAKLDAAGIRMQEMRVQDGNGSPFLVNDFSSLHPYTKFPYACIISQAHTELELNRELEALGGQVFRPLKAVGMKPVGNGLQVSFETGQIITAQYVIAADGARSVIRSVAGISFVDPQGLDREKSGDPRISQIILADITFDSSLDHIFPVDPYTGALSICPDGLFLTFPLAHPKVQSTLYGATEPIYRIGFSVHLTKGEAPSHPGLEVLQKYVDGHGPPVLSSDPSRNPNKPVHLKKVYWSTRFRTHSAIADTFFRRIRGDTEQENGGVVMLVGDAAHIHPPIGGQGMNLGLRDAIGLGATVAKHIQSKDANNDSNLQMLQDFAKERHEKASKQIVMTKRFAWFVGSLMNPWSIPYWVVYVMGNISFFKKMLVWQLSGLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRF6</accession>
    <name>A0A8H5LRF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRF6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="812" mass="89243" checksum="9687D1593E5A5EE5" modified="2022-01-19" version="1">MRCLDHITRQACPLCREPFDIRTIVKLHVDVDGCGASAPAYAEARRLQREIAQVANEGTTEPKLRQLISECKTFLHSQDRGLFEDLRVSHRMLAYLCEIKSKSRAQNQEVARLATDNENLQEEVKRLETDKITEIERLEEERAERDRTIVELERIYREERERARDAELESRRKVMEMQERYIQQLEARVLTCGLRYRIANKLRLEMDNLRTELSRMTTTAGIYQESFKPSDAPLISISTPPSGDEELNTVKEERYSTELDFMISPLPEFTTTILPQEYSSLPPIEDLPEGNSTEDGQRSCGAAGCPFSCNCQTFRLFSMTGQTSAPLELPSPGGPSLLSLTAPRGEDSPHSLSSYSPSTPSDHPPIEDPTSTCPPSPPSPPLPSRSPSNLQVERLRDLLTDSSSPNMTSSMPDLGDSHYSRRERSDSQTSVSSKRPLPSRSLESSTASLAPTPLSVPSVQPASGITPEVTTAVSQPIQQRHGVSRASSAAYALENAQRQIKERQKADLERRRAEKLEDWQTGASRGRSPPVSGVPEMPAEASHGSSKSHSYYSGAGIDMTSSGKGYQSYHAAGIDSQRSSYSNPSTLSSKMEGRSLRSKYESSLYSPGVDADRSSYTTPSSLSKAERRLSRSSSKVNQDANPALEGERSSYSNAPSKLESRASHSSSKLPQEASSDNAGIPVDRSSYSNSTPKSESRASRSSPKTPQETLQPSAKQYFPIQWEQTASHNYQSASTSSSYRDYDSALYANTPPTSSHMTRPTSSTASTQVKSTSSSNGKDGSSSYRQYSSSSGKNKLVSPSSLTANAIGYAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS36</accession>
    <name>A0A8H5LS36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin Tsp2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS36"/>
    <dbReference type="OrthoDB" id="2156690at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42845" checksum="7B415B506A853F0A" modified="2022-01-19" version="1">MRRRSGNFNARSENYSVRLVPREEQSERLDIPAHSEDLGYTPDDAGHASPPCMSRSSTLDSGNTLVSSSVPDKVLHWSKFPKPCNLKRPSISQKHVTGIGMARAAANAMQEGRGLGFNGAGKWTGSKWCLVFSVISVFVYGTVALVLAVLTWFRAWDHADVILVVDFDIIVLLTLSAVLLLFTSLFGLTGTLLNSRPILAIYTLLLWPSLISMLAVGYISFKRYDFRLDKKLNLYWSEYFTPLGRLMIQNSLRCCGYYNPLHSATLSSKCYPRTRLPGCKGKLFRFEKDNLGRIWAATFSVVPLHLLVMIVALLCSNHVSRTFGKGLMPRAYRLNQIDLHQDAEKIENELRKAGVNKVRRPEWTRASSSATLKEDRMPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS70</accession>
    <name>A0A8H5LS70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS70"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="498" mass="56411" checksum="49BCDE59A3C686E5" modified="2022-01-19" version="1">MKTRELGEYKICDTYSPYIEKGGSSREGVDFDIVGMGDVRVEVTYKGVLCQLLFRNAFHAPNVSSNLLSTGVLNKLGYTNTTANGCMVFQNPQGVEIFEAVLERGIYVMNANPVGPQRPLSNVTQLPMDIQYLHRASGHIMPERIEMALKLVDGYPEIKGMRKKMGTCEDCKKAHTDKQPHPESLEKITETNFRWYLDVWGPAQVVSVGGNKYALFGMDAATLKNMRGVVPEEQNVSHLVPFGSIGFAHIPAKTGRGKLDARGFKCQMVGYEGRKVYLVKWWETDELYQTSDVVFERSESHWILELEGENNEDLLFLAPTQKSETPSLDQPTSDQQSYPEPINDLAALKLKFGEPYPCVHLPAPAYEDGEREAYKRGEEWMKDEEQDNELLLEFDEEDEPIALNTQSNMICEPENTWVLHSYTEAMKRPDLWLRAMEKELTKLDSRKAFTPVSKPEDVKVITTRWVYALRLDGNGKITERRARLVVRGIDRGLLVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSL2</accession>
    <name>A0A8H5LSL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSL2"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="419"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="554" mass="61121" checksum="C14F6FF9B54F97AF" modified="2022-01-19" version="1">MANIQITSDEINRLIYSYFKDSGFEHSAFALAKEAHLERSPCFSKHVPRGELVELLSKSLLYTEVEYHFQGGELAANCKTGFSLLETHVCSTTPPEPQTFIAPLIRPNVPSVILEPTLPVRSNGVPDTNASKRKADVPPTNEPQEKRPRREQEAQGENTSDASSKKARNALPTFRKQGPVDKDTDPSSIQLLTGHKSEVFCCAFNPIKHNLVASGSKDASVKIWNLASTSKDPVTLESFSIAESGDLTSLSWNPTGELLAIASYDSVLRIADTSGKIYFQHSKHQGPIFTTRFSPSGRWLLTASLDGTSCLWDVANKRLHRQYSVHSDCCLDVDWINDTMFASCAADRIVHILSIDQENPIKSFGGHKDEINQIKCNPSGTRLASCSDDTTTRIYDVSNISSQVDGIPGLDGSSSTVVLEGHHHSVSTLGWYRLPGTSKELLATGSFDGVTRLWDCDSGECLHFFVDHTRPVYALSISPNNRWMATGGGDGWLHVYNLKSYQKIWSWYAGDDKPGVFEIDWQSHDKLERIAVALECKSVGIIDVSMIPVITNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV42</accession>
    <name>A0A8H5LV42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">D9758_002092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV42"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19338" checksum="E5C787942C864185" modified="2022-01-19" version="1">MFRRTIATQICRCRLYSTSGPEIRDALLARVKEAMKAKDTSTSTTLRSILAEINAADKTSDSKISSSAVISILRKATARRQDAAEQYTQASRPDLAEKELREVNLLSEFLPPLLSEADIDSNIRDALTTLGLNPPVNDRKVLGQLFKQFYSKVDRALVDTEVVKKRAEIIAAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV92</accession>
    <name>A0A8H5LV92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV92"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="598" mass="64171" checksum="4A151FAC9CA984DC" modified="2022-01-19" version="1">MLPNHPHSLSYPFYAMDPSAVDFRAFYPYTPNEVKHRKRTTSAQLKVLESIFKRDTKPNAALRNELAIQLDMTARGVQVWFQNRRAKEKSKATKSATASSTDSSKSNNGASDAQDPAESAIIPPTATFPRDLPELEPSSSQGSSPTGNSPPHLHVSCDSNQTSWNGSPLATPDDFNQSADFSQMYMIRRGSLPVDMFPVNEDCSRGPPLVGHFDPFIRRRSVDASLHRLANNPFANLARVKNGMAGTRLSGLSNEHFRMSSAPQPPLIPEVPMLSHSRHSSADSRTFRFPPTGVPVSVSPSPSPLSPYNVVRSSLPDNQLYAFSHRQVPDPIPGPLPSPDFSFGVANHSSVSLTSPSSERNSPDHHLHGFVFRDEEIDTEDDATSTFSSRFGSVASIGTSESSATSAFYSDVGSGHELGSDGSCHSRKGSGHFVTGLMSELNVSGIGSHEGSPVADVPRMTAGLKVHDGTSTYSSPSSTVSPGSVGSPGLNRSSELVFAMGKSDHAAYPDSSNVNSAPFYMGDNSSTSLSVSSESNLPLEFGSEYPFVQTDVSGIASHYNGNGSFAEHLNSAQYNQDSYHLSYSEGLDGNSVSTSHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVJ2</accession>
    <name>A0A8H5LVJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_004107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVJ2"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5371108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="20148" checksum="316F55708D39CC98" modified="2022-01-19" version="1">MQGWEDVYLDSRKAAKTWRPKSGTMSPGLKRARQPYLVKNVITGIILGAFVVGVYTYSIRAVKQDEFDDIDEEAKVQAKARLASIERMPVLTVDEEKKTMQAAARAVASSIKTGAGAASASGAGLGESGLVTEAVQASSSQAAWTAPRGTRGILPKYLDGIPGLLDPNTRTLVWGAPPVDNIGTMSKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXU6</accession>
    <name>A0A8H5LXU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXU6"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5373552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="46748" checksum="8416B51A6F1CFFE9" modified="2022-01-19" version="1">MSTAEPLFLPDIDDDSQNPPPQDIDIDEIFKDLEDDDLFNLPAPSRQAFDVEAVKRKADAEYKRSAAAAKLSTPRPILPSSSPPRDLGDGVGTVGGKGQSGAGKTSKDGEPKERRKPMRLDEARLIGPTGFPQLIQSTKNFRIKGKGHEATDLNRLMQIYQYWTHSMYPKSQFRDTVERVEKLCHSKRMHNKLGMWRDEANGIKPQEESEEEVIDLTEQAEQEETRTPASDAADYTSSSPIPTRPPTSPDISGRSDVDDEALDAAMRDLDEVFHATRNTQGASATTESTNVSQTITDKQKSTQASADMNVDDEELWASLGDFDGADFGDGAAVPKSAPGTGKNSDWEEMDNEDLMAAFDDAHQDAPKTGTLAAPKNMLDDEDMWDLVREAEMEETGTKSGPAPATTKRPLSVDEDPDMDDFYEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYE3</accession>
    <name>A0A8H5LYE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYE3"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="49"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="653" mass="72512" checksum="A99DAD90DAD0DE6C" modified="2022-01-19" version="1">MNISWRRACLQVLSSPQRQWGIAACRGFRSSSRSDAPKSSVRMEDYACDVIRNFSIIAHIDHGKSTLADRLLELTGTINKKEVGRNMQVLDKLKVERERGITVKAQTASMIHQYADRNYLLNLIDTPGHVDFSWEVSRSLAACQGALLLVDASQGVQAQSISVFHIAKERGLTIIPVLNKIDLPAAQPELIASQMESTFGINPADIISISAKTGKGVEAVLQAVIERIPPPPQSGPKDPVKAFLFDSLYDRYRGVISLVNIQSGMLQKGDRIASCHTRKKYEITDIGIMHPEEVPTSSLHPGQVGYIACNMKVSSEAHIGDTLHRVGEPVEPMPGFKPSKAMVFAGIFPIDSSDFPKLEESIKRLTLTDRSVTVQRESSSALGQGCRLGFLGTLHMDVFRQRLEDEYDANIIITAPTVPYKLIYRDGKEVFISNPTEFPDVLGVGSKVAEVQEPVVKASIIVPEEYFGEMMDLCHSHRAEELDHRYLDTGSDSSSSRIILNCVLPLSEVVTDFFDQLKGRSSGFASFDYEDAGYQKSDLSKMVFLLNGKPVDALAIIVHKSAQDKVGRAWVKKLHTVIPRQLFELPIQAVIGKKVIARETLSAIRKDVTAGLYGGHYERKMKHLENQKEGKKRMKRIGTVDLPQEAFFDILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7E1</accession>
    <name>A0A8H5B7E1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000474">
        <property type="protein sequence ID" value="KAF5317611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7E1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5317611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="526" mass="60401" checksum="34C56EC783E3A211" modified="2022-01-19" version="1" fragment="single">MNSLADKEVEDQRMLNAGGYDLPMGVVGKESSLTSGEPPRGIKRGRVLAETNQKNDTPGNDDAIVKSRRVEMDDGQHFSRTTMSEAHLRSFEKLEAKLEEYKKKVRELDATNIRQSDKIDSLARAVDRLETTQKTMEAQKRKIAEQHEALEDQFNRYQKEQELKSKLADRKKKTPLQEGEISYSTKIDKLDAEAVKVKILKAEVAELRQELQELQVYKLNAEQTDAESAKLQNEKQELGKLRERYEAENEKHVADLLNAKTDLTTAKEEKSKLQEERDRVQGGFNNLRDEKKKLREANDTLRNDLGVVTKDRDGLQPQIALEKECLEAIGNARQSELDSRKAKDELAKVQQDRDHFQGRHTKAQDDKKLLQQAKNTLQKETVDLRSEKSKLESLNSSLRQSEAMAQDDLKKIQEERDGLKADLTKLREEKDKLLNDLKKVEAATNKLKDDLMKANEENEVMKIDTDLRLDEDDTMDELRTRVADLENDLQESRISHGNCEDIICELTEEVDELDRKVKALEVSILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BBV9</accession>
    <name>A0A8H5BBV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000411">
        <property type="protein sequence ID" value="KAF5320385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BBV9"/>
    <dbReference type="OrthoDB" id="3262196at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5320385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="610" mass="69967" checksum="C0C6B9228E82E2F0" modified="2022-01-19" version="1">MVLNECLGSDSQRRVLTTLFGGLGNQTPLRFLIASRPELVIRDFFGQLPHRGITTRTELSDNYSTSRDIEVYLRDGFKAIVEKSHSDVMAHIALPWPPIGVIHELVQRASGQFIYASTVLKYVGEEYSLPVERLELVLGLPLGDPDAFSELDALYRQILSSNHNKARVAQILGTVLVIDNIEDICSVPWAEEKPSWLDSHTYDPRKAIRKGIDLVEQLLSLPTGAVMVSLRGMHSVLQIDSGIVKLRHKSFLDFLFDARRSGEYFIDKALFHEQLARVCMRITNDSSPSLRSYAMYNCLKHIHLAKSTTDLVTELRCFNFCDMIKWYLRRWSYRAPPVYVSQSISVFQKYAKVLESHQIKTWSDSLQLGIYVADTDRRELSKEFLSELELLFALAMDCHYAPLDAILPHKTPSNVEVLCGLGCTISYPSMKEIFVCLNPSLHSHSHSRASRNPVWHFIDFERGYEKLANHCLRTIRLNPCIKDLSRRQCLTMGLSSSLWGYAYAQSRMSELLYYSPLDLELQHELKKTMPYLNGTKELHKVLLWLQSFPDDQRDIPMEVAIWRCSEQSHELSDANLAFYLWCQGQAVWISARSVRLLTRRESPCYKSGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BQZ1</accession>
    <name>A0A8H5BQZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000378">
        <property type="protein sequence ID" value="KAF5327980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BQZ1"/>
    <dbReference type="OrthoDB" id="3262464at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="221" mass="25159" checksum="A2A6734FB47F88E6" modified="2022-01-19" version="1">MILNPSMKLDWFRYFTPHRLHEAKELFLHEVKSYAAAVASDSQQTTLSDLSNDNWADTILSLPTKDKQPDEINGYLSEALANPKKDEIAYWEVRHSMSGILIVAHNRMDIQDSQACFPTIFHLALDILPIQASSVPCVRVFSLSSDTDTKKRNWISPELNEALQMLKFTLQHGNPLSFTDGTSLEEELAVLKQLLAEQCDKLEDKKVLIEKLLQMTARDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BT40</accession>
    <name>A0A8H5BT40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000348">
        <property type="protein sequence ID" value="KAF5329075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BT40"/>
    <dbReference type="OrthoDB" id="3040293at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5329075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="725" mass="80999" checksum="B4F75CA2B7604914" modified="2022-01-19" version="1">MSPESNTGPVEITIQPRFKKPPACDYCRTRRVLCHPQPEGRSCPRCLEKGVKCTTTPSSVRKKRRRQREILAAKKEDDAGTSQGQELVASRALTVTTSAAQYAPRITHMLATGADLNDVYRRPIAFAPSSARPQLQLPKRLMEDLFNDFFYTPCRIHPIIPYDRVRARLAGCGWRPSSLSPQECVLVHCIFALASTVSIDPLIIGPEPFPKECINILSIINPVKNIKSDLREIGRRRENVGLCHQLRAEALRLAQNEGIAVCVSPENAASCCLLDTLLSQYDGPTSYGAAFTWQARRLAESWYKLPQLYNWAFGTIGLSITWTAFLLVDMLAALHSDRSADFSASDEQLICGHEQLSLEKLESLLSQGCNSWQFYGHYISITFQITRLAREVYERIRGPYTRGRPYDLQLIKHYTASLHLLHDVYNALHKQGVLLARQNQSQNFAITGTVRMVSIGWTNLTLHFYKTMKEMLEESSVTDLYYTTTSGGPWHGHGIDIIDGLDGLERGTYSYSSSLAELELTPIFLAVRTLTCKAAIDHSEMIEDIYSISRLTQTKFVGGDLKRWVEFVIDVTDSGVMSASEGIQALERLRDGLKIAGFTWRTDTDLVEVIDSHVSALMDSSSASAQDPAHLHIFTLDNPDLNYHHTHLNPHPDPAMGYDPDIDSFRNLEINSISGHMHVPPPQASAGVPPGPGPKISPYDHDHDPLVSGYTYAYASTRSSDFFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0P4</accession>
    <name>A0A8H5C0P4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000297">
        <property type="protein sequence ID" value="KAF5332955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0P4"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5332955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="247" mass="27507" checksum="D3311FE1F8EA5761" modified="2022-01-19" version="1">MNKGSKSRRLSLRILKQLEDEKQAAQDEVDKALDKKIEAAEDLKNEDIVREQFYMDMVALVKDKKTPFLPFFPSSRPVLLSNHPPVVTLLILMQAKWSNSDVDIMIDELKNQKAQGNQSQSGWKPDTWTTVSKRIIAEGSQEGAEKNPKKCSDKYGTLKAQYKAVHYIRTKALGFGWDEQKQMVVATPFMLVVLPLEPSQSQEELIEWPSSPPASAPPPSSNSNLTVLASVSAAVPITTPARKTSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C1K1</accession>
    <name>A0A8H5C1K1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000297">
        <property type="protein sequence ID" value="KAF5332956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C1K1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69403" checksum="C151D448F46D92E1" modified="2022-01-19" version="1">MVSRRLMWENNNLSSMDHQPTRPPLPDSLDAFADLRISPHVDPIARSASSMSMRSLHSIHPPHTQRIMDPSRHLNGLPPSPHYTRPPRDDSLSIPQDRRSDSYLNSDQASFYPNDEYTPASPDSYASQHWSYPQQPPPGNPNQFYTAASSVLGMGPPPPSQQPPPPPPPPSIGSGYSAPGYQSYAASQTSLSSSHSGSYPASSSYHTSPPPFPPAGNPSLPPISDANEIEPRPSFSRGETVASVRPSTIKSKAVDLATPPYTKEYIDQYRQRIKGDPDPESHFLYAKYLIDAARKIRTSAKDQRSAKKYSELLIGEALKVIRRLATQGEAYAEAQFYLANCHGTGALGLQVDHERAYHLYLQAAKQNHAAAAYRVAVCNEIGAGTRREPPRAAAFYRKAASLGDTAAMYKLGMILLHGLLSEPKNPREAVGWLKRAAEQADEENPHALHELGLLYEMPNSQLVPHDPAQARQLFTQAAHLGYTQSQYKLGQCFEYGTLTCPVDPRRSIAWYTKAAEKGDAEAELALSGWYLTGSEGVLKQSDSEAYLWARRAANKGLSKAEYAVGYYAEVGIGINQDIEFAKRWYMRAAAQGNKRAMNRLTEMKRMGNKRVNVARPTRQQAKDECVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2Q5</accession>
    <name>A0A8H5C2Q5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000271">
        <property type="protein sequence ID" value="KAF5334070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2Q5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="241" mass="27095" checksum="3194EA0EDFE37AC8" modified="2022-01-19" version="1">MTMAYCLRGPTFGKVDAPRQDFLWYLVTHTKEEGIYIDWELADARTKKTRGARCKGFRDVKVLLEKWQFFCKEQHTHTVQRDKFPLHCVNWFALEQRLLKLAGLLEHEDISESGSESSDDNPVLVLAPLHLSVASPQSRPPPVIDPTLLTLHAAQPSSSPISPCRHTQEISIPLASQAHTYSGSGQLHTNQINSGFACGRVPSDVVHARQKFLEAWQNGLDVQMVVTHDINEGMSLLKDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2R3</accession>
    <name>A0A8H5C2R3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000270">
        <property type="protein sequence ID" value="KAF5334085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2R3"/>
    <dbReference type="OrthoDB" id="3267748at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17896" checksum="6F2F5050B15AF845" modified="2022-01-19" version="1">MIWVERQIEKALWSKQRGEGERQTKRSQNMGGSRTRSMEVNAFQNNNPGASPKIKYPPKLTNEERERMKKEGRCFGCRGLGHTTFNCPTFPRSTTSSSDNTTEKPSIRAATTEPSPSRTNTIMKEIAEEFTAKVRALSGEEREKATGYLKDLITESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C310</accession>
    <name>A0A8H5C310_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C310"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="283"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="499" mass="56929" checksum="B5699A73D31379B7" modified="2022-01-19" version="1">MNDAAETPSLLKAALINGSWKDFSMCCIDRDMQLRFSEIDPMDSHFYWSLFRRIFDDWKDAFDAVDLDDKPSWPEFAASVWTLPNVVQETRCHVIRGYCGQRFEVLLKSNFQVVELSETCIQNLFKSIYDEILDLHSTSELECRYRFAAYVSNEPSASKALLMQWVKFELEANAVQALQERCILNPGLHEREFYDLTRGIITETRRLYNAVLFGGFSLADNHHVRSLDDPYLFSLLPRNWNDDPQQILDCLWDIRAASGHRAVYSRTFPLDDKRMIKYSDQGLLEETIAMELVRIKTSVPVPQALMTFVRNGQTFLVMSRLGGEALAGKSDGLSEVELAVISQELAQHVNSIRRLGALLNPSGSDSPPLMGSWFGGPLENIVFDPAPSSAFQSSDDLRYYWEQRLKRHRQIQVPESFNLVLTHGDLNPRNVMVEDGHVVGVVDWDTFGWYPDFWEIMMLTRQAKPSVGQFMTTSFLAELGTTAGAEDLCKAVSEALYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4C4</accession>
    <name>A0A8H5C4C4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4C4"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="279" mass="30474" checksum="D4EA2F78CA23DC5D" modified="2022-01-19" version="1">MAPSFGERAKIAKDTIKRSPEITREHAAQGATLDSTFIAEQLPPLDSAKCPSPEHIPVPVEVIDSDAFTAARSIMKDDNDAVGKTAVLNLASDIEPGGGWVITLSKTQEEALCYSSTLWPTLKPEYYPWPNVGPKSAAGVFSPGIVIFKDDLDHDCVNLPNEERRVVSVLTVAAPRGPLLTEDGKNFKKPSVLEDLREKIRLVYRMAAHNEGQYLVLGAMGCGAYRCPPHLVAEEMKSILLDPEFKGWFKQVVFAVYASPGTGATNFQVFKEVFDGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7T7</accession>
    <name>A0A8H5C7T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000220">
        <property type="protein sequence ID" value="KAF5336797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7T7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="967" mass="108856" checksum="DDFE639DF751B980" modified="2022-01-19" version="1">MDPSSTYHTHGTQSTDYSVPSGSSYDWRSSSIPTSSSRFFHDPYSQPHVGSHPEYQSELENSPFPSATRVMEPPSHNIYLSPAPAPSSSFSEYEESSRQPPEVCENCDSYRCMADDKTLLTRMKASTDADNIHNIAKTRLLWLWHCVEEAFPQGYGRQVEMWQSLLDMDDIWLMWDNGDELRVPEPNTYLSSYRAKSFRNSAVSSISRRLERHFSGQCGLDVSATSSEGAYHQFEIRFALILWKSLFACRRTKFKLRPSSIGHEIPSLVSKWWTMLPEDVKDELVSFSDLRSGIWGDFCATLKQRGHTCYKDLPDESMWKVWITIGNPLRAIPWPFHLVNCAGCLKIQSQPSGLTFKLKPHLIALFCIPSVAREYFYYMGENTAPTSSKFWTDRWIDSDKRDGSRTKIKLLPNLLSQTSLREMDKWLSNLPSVDIGRKHTLGSFIPKEDWIPSYWVNLLQVNEDGLSVHWTETEAAVEAATGIACSRYSPAPFTEEEVAEGSTTGWSSDPASWLCAVALLSIVKSVGFGPRAAQILKDTLRNRWFGVSLEQAPALRKSEATRAFQNSLEKSGHTCWTDLEALGENSIPDLYASAYSMLTGNSQVPVVGCDQMDPDLDRHMYPRLDSKCRTCRIQDGLHDLSNALDNPKSTFGLSIDAKRMISGMNHDRYQTDRCPLTQKNLLEFSQTLIETGNALQQQTQSICCSGCANSAAHCWEEEEEEEVENIICRGYMDNDSEDTDSEESSTPPPPPNHSEISSQSGSNDVALNGSSTANELLSFQEDYVEAAPDISLTSRTDLGLIPDQDPDKTTSGNHSINRPEAQSTTKSSKPKNRPSRQEMRDNVKLKLLEMLDSNKIYYGKGLPWKTLQEIVAEQGFEFVNWPESKGEPVQLTRQDGIQKATGPEISPLYDALNDEERPLQIRRKNAAERNASERAGNKRSRDEQEGDVERDSAAKRARTAEPSNSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7X7</accession>
    <name>A0A8H5C7X7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000222">
        <property type="protein sequence ID" value="KAF5336755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7X7"/>
    <dbReference type="OrthoDB" id="2994945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="22439" checksum="042F2859C665004E" modified="2022-01-19" version="1">MVAHERISDDLKLAAICLYENGLLDLDDVLACVGFSRRTFFCALCLWQHEGIVSKHKSYHVGHPCTLNMEDHQYLLMLVNHNPEWFLDELHDLMDENQHIAVHFTTIHRKLKHAGISVKDLQIIAQEWNPDCQADYCSTVARFQPKQLIFLGEMSKDKQTMQRRKGQARKGVRACWQGVRSGLYFESADWAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9S1</accession>
    <name>A0A8H5C9S1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000215">
        <property type="protein sequence ID" value="KAF5337548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3027122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055440">
        <property type="entry name" value="Beta-prop_WDR90_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WDR90_beta-prop_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="367"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="938"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="WDR90 4th beta-propeller" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1347"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1430"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5337548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1555" mass="172053" checksum="46D4CB60FF71084A" modified="2022-01-19" version="1">MPPANSFCSSQIIAIDPKKASADLPFSSLSTSSFEASVSAPPSPAPNFVPMKLKLQALISRSPSPMPQESASDPAVDRSSFEASISAPPSPAPNSKKKLLARLSRSPSPMPQAPAATSVSGSAVDNSLLAPPYTSSSGRRSPVFGSKFNDPASQKPLPDLPGNDGQDGKSRLEHITESTAFRSMKTLLKLVTAASGAEPTGALKIASGSLLILMEQAEKTVQTNTDRKAFMNSLQSAVDDLERYSQDVTSGSLGDHMKTLQEDELEKPWWKRFLAASEEAEAMKGLQQVVRDLYQVFMMELAIQMAINIEKGIETNREIKDHLEENLGDLKTCFKEVNQLTGRLAPSEKAEYNAMTSAPREPCTKGTRKEILEKLMDWAERDTDHPIFWMNGMAGTGKTTIAYSFCQELLGKQMLGASFFSSRSEDETADPGRVLPTIAYQLARHSPEFTAALLESLKTEEDSGGTPCESQFQKLILRPARTSRSAFGQMRLVVVCDGLDESKDLNQISRILSLLIQHTLDLPIKFYISSRPEAEIAIRFTDANSKHHEKFLLHDVAKHFLERDLRIFLVDRFEKIRTEKEIPAGWPSGDQLNRLLDLSGKLFIYAATACSFIGNPRFLAPQTREALKDILSYSASHPNANNEASYKELDTLYSAVLVSACGDNWNGMENEILKNILRLLIAAHTPLSQTAIAQLLKIKPLSSRLQSALSSLQSVISVPNHSLQPIQIFHASFPDFMSDHDRSKEYHLTPQESHCFLAKKCLDYLDHLSKNCCHLQSKNVHVSQADTVAYISKPLQYACTYWIAHYLAAADKSSLQEPVKKFFKEHALCWIECMSLLGKLEVAVKMLRTLGNAQSVDHETQDLARDTRRCLLQCLDAVRDHPLEIYYSALFWLPKESLIRKFYGSKMCWGGGKELGGGKGGWELPIGQQNVWERCEQIFTANSHVNSIALSPNGQRVVSGSQDGTVHIWNVETGEEEQKLKGHSNQVTSVAFSPDGWQVVSGSFDGTVRIWNVETGEEEWKKHSSWVDSHVVSGCHDRTVYIWNVKTGEEGQKLKGHSSEVNSVAFSPDGRRAVSGSNDKTVRIWNVETGEEEWKKKHSSWANSVVFSPDGQHVVSGCHDGTVYIWNVKTGEEEQKLEGHSHEVTSVVFSPDGQRAVSGSRDRTVRIWNVKTGKEEQKLEGHSGWVTSVVFSPDGQRAVSGSYDKTVHIWNVETAEERQKLKGHSDWVTSVAFSQDGKQAVSGSYDKTVCIWNVNTGEEEWKLKGHSDKVTSVMFSPDGWQVVSGSHDSTVRIWNVKTGEEEQKLKGHSEQVTSVAFSPDRKQVVSGSVDRTVRIWNVKTGKEEQKLKRHSKWVNSVAFSPDGQRVVSGSFDSTVRIWNVGTGEEEWKKGQSDWVISVAFSPGGWQVVSGCQDRTVHIWNVKTGEEEQKLEGHSGPVSSVVFSPDGWQVVSGSYDGTVCIWNVKTGQEEQKLKGHSDQVTPVAFSSEGRQAASGSDDGTVPSHFVGGQWICHPRMGESLRIFLPFPNFSCTTVHLDSGSLCFGFGSGKVLVLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFJ0</accession>
    <name>A0A8H5CFJ0_9AGAR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">D9758_016593</name>
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        <name type="scientific">Tetrapyrgos nigripes</name>
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            <taxon>Marasmiineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="69" mass="6975" checksum="128764CD7095536F" modified="2022-01-19" version="1">MGPGEVGDVGEGRRVGARVGANGGNAGTNATGHANEGESSKRHILLPQILPRPSGHAFSNGGQDITVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLH8</accession>
    <name>A0A8H5CLH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">D9758_012922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
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            <taxon>Marasmiineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5343986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLH8"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="8331" checksum="3D19EE88EF650D88" modified="2022-01-19" version="1">MAWKQVRSDRRRKGDISYMALANPAGSQGNEEFYFPSVRMELHSTKAIELMHSTMDKGFVGDELAMEHASGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM36</accession>
    <name>A0A8H5CM36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000142">
        <property type="protein sequence ID" value="KAF5343328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM36"/>
    <dbReference type="OrthoDB" id="2658733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="350"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="481" mass="54710" checksum="9BD65F7118CEA969" modified="2022-01-19" version="1">MIDVSIAIANINVRIGIRDLHEIAYAYLLPLWLRHSRNFHLSITNTQLCNELHVEMLPRVPDIDAIKEKCYTLKGRARVKTLVTNRAHHVFLHISPRFAEEAEFRRTMYNEKDLPALTDQFVEVVLLFLYIPSFSDLYIIQIDAGTSKSRTRTRTQALTRTTHTQRTRRRTAQKVLTVVETIEIDDSSSEEEPRPSKRQRWANSDQSTVDVPPDSMVLDQEIVGRLPFPVSGLVSIPMPQAIQRPKSDAIRDALSKQRVDRKATNDMEFQVTLHFQAFVLPKYSWDDLLENPTHCYHRNEQTGELMNFDSGHQISELSRELNCLLWGKVMLGLVYQFIQRRDVELGTTPSFPIPHLRFVNAALVIGKRTDGEQSVYMMEEIVGGAHGWSFYKYICNGTASPLIDMGTDQAAHVQFVETDGLAYTSDFQGDGNLLTDPQILTKPELGTNLFAQGNVAFDSLFTTHIRLVIDILGLKVVVGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMC1</accession>
    <name>A0A8H5CMC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMC1"/>
    <dbReference type="OrthoDB" id="3250682at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="546" mass="59832" checksum="3BA086BAA5EC2CB1" modified="2022-01-19" version="1">MCKVNRPESRNFKQLAWRRRTESRQNGNFSSLHPYNKVFDRPPHSPSKTPFLGSYEYHILSSAPLSLLYRTPPPLFGSSLHIAMDSSQVITVELAYVWGIIISTFLYGVYLVLFWIAMYILLLPLTAPYDTTREPVNKILVTVSVLMCCTCTTHFVAQCIRLHKGYVQRMHPTETLYHVGSGVDGPMPYLENTNKPLAIATGVCFTVAALLTDGLTIYRLYIIWNRSFNACILPIISLIGILVCGLAVCGLAAEMAPSAPLFGSTAAEWLIATFVCGLTTNFIALASVTVRFRQNAQDKKTSRVPGATGSRNTTKMVALIMLESAAIYSGTKFINLMLLVAETNVTFAFFCICIPMTGIASHLLIIHVGYHKYFGGSGIGTGSVHRSFSSRIASGHFTSSTVGGRSTPFTHLPFSPRSSQFIRPPLSPRSSQVPPTLCLSPSDNINYKTDSIRNSIAFSPTRIRFSAGPGDGDPEDDDRESQDRLSGYKNHDRDNDTDRATVTEDDEPKTGSSSSSSHTHHGVLVPSVIIGESVTRTMTAPSDGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNI1</accession>
    <name>A0A8H5CNI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNI1"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29642" checksum="EB3233C2189E6B27" modified="2022-01-19" version="1">MAIPTSDSQDDRPIVWFDIDNTLYSASTNISQAMGVRIHGMRPTSFVNKYTGVNDIVAYFVGLGLDEQEASELHHQYYSQYGLALAGLVPKSRHPLDFDRKCDGALPLEEMIQYSPSLRKLFEDIDRSKVRVWALTNAYRPHAERVLRILGLTDLVDGLVYCDYEAKDLIAKPEYAYYDKAMKIANVYDPSKCYFIDDNKRNVNAAKELGWGHCVHFCEGGLVHVEGGKAEEIKSIVKHEDDISVSDLEQLRTVWPEIFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNR0</accession>
    <name>A0A8H5CNR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNR0"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69761" checksum="0AD71C7B8A388CA6" modified="2022-01-19" version="1">MHQPPSEFPLPTLDHLGVKEAPAKDLDAKSIVTEWFTAFASNAQSGNVKAIMDLFYHESYWRDLLALTWDFRTFIGPTKIAQFLYDRLAASQLKALELQDDSIQLQLPFPDLAWIQFTFTFEVSNTGTGSGIGRLVPQPDGRWKANCMFTNLEGLKGSPEQIGALRDTETDHGFWERQRKEEIAFKEAEPTVLVIGGSLNGLVISARLKVLNVSTLIVEQSPRIGDAWRKRYETLSTHDPIHMVHLPYLPFPSTWPEYTPAYKMANWLEAYADSLDLNYWTSSAVTKVEKNKVSGRWTVHIQQGGKQQVFTQVKHVVLATGFAPTHNLRFPSIPGMETYQGQTLHSTQYKSARDYVGKKVVVIGSSASGHDIAADFVRNGNGRNPNLLHLMPPGTDVGFADTTMIQRGPTFIMSAKNGWTVLRAGMYNEDGPPVDVADRIGASFPYAFLLNGMFQRQVDAICELDKDLLAGLKACGFKFTKGRFDAGPLPRIQENLGGIYIDTGASKLVINGSIKLKNDSTIESFTNTGLKFANGSELQADVVIFATGYGSHNAIVHKLCDEETAQKCKTIWGVDEEGELRGCWRDLGVPGLWFMTGGLALCRFWSKHLALQIKAIEEGKLTSRYSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNU2</accession>
    <name>A0A8H5CNU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNU2"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="34892" checksum="DA3A3E7D3FE20171" modified="2022-01-19" version="1">MPVKCTRISMNSSLLLGTYGCRYIMTRRKLEILDTMSFQKAFVLDSRKGSFIVTTRPIPKPGSGSLLVKIQATALNPVDWKIQAHDLEFLAKEFPAVLGSDAAGDVEEVGEGVEGWKRGDRIYFQGYYTNDQATFQQYCLISADVAAKACAMSSFDETFCSPADIVFHRSQKDIATPKQPLFLLPSHVVYLVFSPEADRSCFESYFRPHCEVYGTASSGTIFFLLSVSITLTYLQSALGVLHQSGNMFSPIIAYASAKHGPYLKELGATHIIDRQSVSFANLPSTVSNILSETTSSPSNSSSTPFLVTMLKKLDTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP55</accession>
    <name>A0A8H5CP55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP55"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="51847" checksum="BA1C83A729A44B2E" modified="2022-01-19" version="1">MLSVQPSPKPKFPSELSPSALRPNGNLTPLLSPRPGSGFIVPPSPRYGAAGETLDEWFHDFQKYEKTLAAMAEASSDPKFREELGTIEQCTNTLLLPLLQNVKIISIGFKLLTESEQTASLYTLLQHTNPAQIKFLMAVLQQMSDAIPPSENPGSKQPSRSSLRPPNLNIPLPGTPNTPHFNAGVSSAATHDSAPKTAEYTAQELAVKEEPISWANMVSTPHDLMFKKSAEQQQQQAGMQNLQNLINSAGAGMGMQMNGITPFNVTVLSSMGFSNEQIVAMQLVMRGLGQPADATGISGPGTGQKNAQPHGHGGHSGRSNRSNNNHSNSGNNSNWRSPGSRYPGSALRNGQKSATPKSAGPKSSGLSSATSTGGTPKTEDDVDPELLKDVPAWLKSLRLHKYTACFEGMGWEEIVVLDEPTLEAKGVGALGARRRLTRTFEVVKKKMGMETASTSDAMPASAALASNGPSLSSASPEKTVPHSAAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYN6</accession>
    <name>A0A8H5CYN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYN6"/>
    <dbReference type="OrthoDB" id="3262409at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="184"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="363" mass="39632" checksum="5BBD88906ED3C470" modified="2022-01-19" version="1">MSGIPPPSPPVSHDTILGIGPVLIGALMSYLLMGTLIVQIYIYYMSFPNDGLFVKLTVYSVFVLDLISTVAITDSAWLMLILGWGRFENLHLVDWGFTTVPLWNSLSSAIVQVFFGWRVWMLGSQHSINEFEKKFWRTMTVLIFAVSVTQVVGAIISTARFFPINDLAFISIVFPSTTTWLSASAAADVMITASMTVLLSRAIARSRRDHVSHSTRQTDALLTRIIRNTIETAAITAGAAVLELILFLRLPNTGLHIAIALILSKLYTNTLLASLNSRASFRREEGSIGSLSSSGNTRVTTGPMSLNDSRDHSTRASNGTRVYFTKASNVSHDKGYAAGITSTLEDDIPMNTYSRGPTSPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZ39</accession>
    <name>A0A8H5CZ39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007839</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZ39"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="117"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5350238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="41913" checksum="DE3EF76D8D3068D3" modified="2022-01-19" version="1">MRIRNSALHILQLGIERKYKDSDLGVESSSSCSSLLLHLPVWFIMFGRLLSSLVGLSCLMTVLGGPVTLEKRVPMFDQDITAPHPVPKVVTREPMFDQNITAPHNVARATNAVPSNPRFVVYGDRFVPGLFSPPPADQIGGFNVFVLSFLLISGPADKAPDRASIKQQYNAAGISLIVSAFGSTDAPTSIGADPTATAITFANFVKTWGLDGIDVDYEDFNAFNAQDGSAETWLTTFTTALRAQLPQGQYILTHAPVAPWFSTAKFPGGYTEVNRNVGSLIDWYNVQFYNQGTTEYTTCAGLLTTSSSTWPNSAVFQIASNSGVPLNKIVIGKPATSGDANNGFIPTSTLATCVNQAKSQGWNAGVMVWEYPDATSSWIQAVRALAFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZI2</accession>
    <name>A0A8H5CZI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZI2"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="114" mass="12152" checksum="9C641D24DDB89166" modified="2022-01-19" version="1">MAVVCFQRTEDAAMVKAKYDGKCVDGRRPIKIEVITDKTPSSSSSSGFASTEPAPPSLIDRIQGRGNANAVPSTKKHSLPRQEAAVAAMMASSSSFTPLNVTPNPDSTQSTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0V7</accession>
    <name>A0A8H5D0V7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="1500"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1740"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1597"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1770"/>
            <end position="1779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5351531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1996" mass="222699" checksum="CFD14B3A034E9DC9" modified="2022-01-19" version="1">MVFPTQQGTQSQTFKPPPPDFSLNLLEVHDFNAEHSPNHPLFRYMTDDETAQTIYWGESVQAFHVAQGFVQTLTPVTYYTLLMGIMHAGFVPFPISTRNSEAAVAHLLKVTNAVNVFANPDNAMQSLAQKACHQLGEGNGIQILPTPVFDDFYKPTQKDFKSSARSRKIELDETAFILHSSGSTSFPKPIKISHRNFLGHGIEPYYGETDYCGQVISAAAFPMFHMSAIILVPETAMVGLTMSVFRPKNIPIIPTPENLFKNALVTKCTIMLVVPSMLETWAKDPVKVEVLAKYTVVGFGGGPLVPAVGNELVEKGVTLRSFYGSTETGAISTTTQQAFKEGWEYFSKCETHIPSVLDTDIDGQPAFDTKDLLVRHPTNPGFFKIYGRADRRKDQPISHRILALRDEKITHAIMFGRAKLQAGVLITPLDALVFDPADTVKLAEYRNMIWDVVQRANGISPQHSKILKELIVVTTPSKPLELTAKGTPRRGSSLKAYEEEIEKAYQALEESSQPNIQAPAVWDTISVTIFITEVVENALGFKVHEHDDLFRVGADSLNATYIRNTITRALRDVKSIQIPLASIRALPENFVYDNASVAALSKFVHDIPHTYATGTGAGEEKDKEEDGDDDDDDPEGDYQWPKMGQPGETILQVRKGKGEPPLMIIHGAGGRADGMIHFQQKFRSALWLFQVTPDLPRKSLREHAEFYYRKVKELRPHGPYRLATYSGSHLIGFVMVEMMLKDGEEVIQFDMIDQSPSFMFSGVSEDGRGFGDGVDTVADSNSDSVQMNENGTARPDRPPLAPSFPNPNFNITSPSFRSTYKSRMIYGFYDTGAREGRTQILNVLKDAWEGRPAPDVLVELAETAKWSADESWDFVAGLPGYQESNAPAPQFKNTWERCLFAIEHWLKNISGISRVPITVYVASYGSVGGVKDETEKEKWKESGLGVRRCFPDARVVHVDTGHLMILANKEVHDFNAEHSPNHPLFRYMTDDETAQTIYWGEAVQAFHVAQGFVQTLVKNDHIDSQPPPVIAILATLDSVTYYTLLMGIMHAGFVPFPISTRNSEAAVAHLLKATNAVYVFANPDNTMQSLAQKACHRLGEGNGIQILPTPVFDDFYKPTQKDFKSSARSRKIELDDTAFILHSSGSTSFPKPIKISHRNFLGHGIEPYYSETDYCGQVRSAAGSPMFHMSALILVPQTAMVGIAMSVFQPKNIPVIPTPENVFKNALVTKCTIMTAVPSMLETWAKDPVKVEMLAKCTVVGFSGGPLVPAVGNELVEKGVTLRPFYGLTEIGAVTTQQAFKEGWEYFSKCETHTPSVLDTDIDGQPAFDTKDLLVRHPTNPGFFKIYGRAVPNPIRRSNHAFCEKTNPFPIESLLLRDERITYAIMFGRAKFQAGVLITPSNALVFDPADTVKLAEYRNMIWDVVQRANDISPQHSKIFKELIVVTNPLKPLELTAKATPRRGSSLKAYEEEIEKAYRALEESSQPNIQAPAVWDTISVTIFITEVVENALGFKLHEHDDFFRVGADSLNATYIRNTITRALRDLKSDQIPLASIRALPENFVYDNASVAALSKFILDIPHTYAAGTGVGEEKDKEDGDDDDDDPEGDYQWPKMGQPGETILQVRKGKGEPPLMIIPGAGGRADGMIHFQQKFRSALWLFQITPDLPRKSLREHAEFYYRKVKELRPHGPYRLAAYSGSHLIGFVMVEMMLKDGEEVIQFDLIDQSPSFMFSGLNEDARGLADSDSDSVQKNGNGTARPDRPPLVPSSPNPNFDITSPSFHSTYKSRMIRALYNMAAREGRTQILDAFKDAWEGRPAPDVSVEVAETAKWSVDVSLDLVAGLPGYQESNVPQFRNTWERCLFAIEHWLKNISGISRVPITVYVASYGAIGSVKDETEKEKWKESGLGVRRCFPDARVVHVDTGHILILENKEVEYMEWDVRVVRIHVDCDKSGQAKPLEWEERMQDVRASPIELYAKNREETQGSRIPTKFARPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0X7</accession>
    <name>A0A8H5D0X7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0X7"/>
    <dbReference type="OrthoDB" id="2873368at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16215" checksum="D3E276EC9CF23F8E" modified="2022-01-19" version="1">MPIITSVNHTGITVVDLERSVSFWVNVMGCKVIERANPTGPKAGAVTGLNVDTDLQIVRLEAPGGYMIELLQYTLPEKREHYKPRPCDVGNIHLAFTVDNLEETKKAMLDAGCVCYGEVHEFGCRLVYLHDFDGVTLELLEMPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5A0</accession>
    <name>A0A8H5D5A0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CDR ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5A0"/>
    <dbReference type="OrthoDB" id="3019805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDR ABC transporter" evidence="2">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="65" mass="6902" checksum="50B8EE83499C3695" modified="2022-01-19" version="1">MKPSHRGFENLMSNESHTLNRTCSNLVPSSPVYSDNPNISLANQACATRGKVPGQSVVDGNATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EWP8</accession>
    <name>A0A8H5EWP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000499">
        <property type="protein sequence ID" value="KAF5314803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EWP8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5314803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="165" mass="18237" checksum="E17590CF867DF4CD" modified="2022-01-19" version="1">MQRPLTPPQSPKLEEQPTASSTPRRFPENQTSRQTMSNPLTNDSTAPSSETTRHTSMYEETRRFKSKDAIESSMAKDEIKVVVKADPATLTTDQLQTITRITNGEDKSGTGAIQSTVIIDGFMIMLIVAAGTEMYKKSHDFEINGGEKSAIGGGKRDFNFDFTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EYA0</accession>
    <name>A0A8H5EYA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000487">
        <property type="protein sequence ID" value="KAF5316844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EYA0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5316844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31023" checksum="33E20CBF177B775F" modified="2022-01-19" version="1">MVDWMPWLKHVPEWFPFAGFQRDARLAREDLEVLTWVPFNKTLERINSGNSQPCYVEFCLDANPNPTPEELDHIAWTAMSAFTGGTDTTIGTLSTFFLAISLHPEVQKLAQQEIDEVIGPDRMPSLADRDRDQLPYVSALVQECLRSAPAFPYGVSHRAMKDEILDGYFIAKGSTVIANLWGILHDESVYQSPHSFEPERFLPKTGTPTNPNIPGRNEPGIGSIPWGYGRRLCPGMAMADSSVWIYVASVLWAFDISSTDKDLTWQNAKWNDGAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F018</accession>
    <name>A0A8H5F018_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000454">
        <property type="protein sequence ID" value="KAF5318283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F018"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5318283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="82" mass="9109" checksum="EFBBF3F8A050F18E" modified="2022-01-19" version="1">MRFKNLLLRNLHQLPPSHAHMVPKLQRLSSLMTQFTPSTSPALGTVSSRIPGLSTMAKTTPTVPEHPNLLQDEYSLPAHQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEQ5</accession>
    <name>A0A8H5FEQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEQ5"/>
    <dbReference type="OrthoDB" id="3066004at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="85" mass="9412" checksum="3DF3ECCD64214993" modified="2022-01-19" version="1">MTHDSWDALKQDYDAKDPLTEASLEKQVFSLTCTNPAKVGKHLNNLITIMDELAKRGVSIPDSQFKLAIISSTPNMYQATVKALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF75</accession>
    <name>A0A8H5FF75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF75"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034661060" evidence="4">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5334556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="221" mass="25172" checksum="EF22D418252CE9FD" modified="2022-01-19" version="1">MLVSRGHSFLLCVLAIVAAALTYSLSQLSRAHTDLANSISSPRLLRPSKSLHYTYIGNDFPEFLPQESQQLVKLVVEDSVHYSLTNTSRKEWMAGMAGSKGMVRLGSQHRAFVVTMLHELHCLTYFHGVLTDTDAFFHAHMHHCLTYLLSMTLCDADLTLEPGDFAERNWTVDRVGETHFCRDWDDVFGTGLLNWIEWYTWKKAHDDDIEGHMVNGLIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHT1</accession>
    <name>A0A8H5FHT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHT1"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5337735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1177" mass="121837" checksum="E5C6D62C5D246FB8" modified="2022-01-19" version="1">METTTEVVNEVEMSEAAPNGIVESPQEPASPTSSNAQPSDSSSPRRPMTRSQSGRPIRRRILEDNALDPQLADDTPSSSSSLSAPPAKRPKLSPKLSKKRFSLGGSPQSGRKTDVGELDENPHIPTSSTTITPPGFLPLTSGPIFPGANVLAGVEGVGTSSAPSGVGASILPATSAGTGTSTSISPPPPPFFSAPGPIHVPYASAAAHAAHVSGHGHGQGVNGPHSHAGASDVLSLLGQTMTAAQHSVHPNLNVSNLNSIPNVIVDNNAHTTTHLPLPANMTNVAPSASASMPNGINGSNTSIASNANVRPAAERIGTTRIMRATLPVPVPNLTKKSRGRRVPVRILNTTPDGTSNGVAGGASEDGIASTSIAADGVGAGVDSSASAGGSGTGIDAMADTGNGGNDANAKDLDKRSYVCSVEGCGKCFHRGEHLKRHIRSIHTHEKLTSLIFAGDDNFAIGLYDLDRNSVALVSFKCTFPSCDKHFNRHDNLLQHIKVHKAAEVNRQVQEEREKEKKEREQTRFSSDLVGSDHEDDVGGGREEGSADDTAPATTASGKGKGKGKGRATSGAKGKGKGKAAASASAKGKNAAKAKSPTKSSAKGKSASTSTRGKAAGKGKGKAAAATTTRSKGAAGRKRRRGEYESEDEVEDEEEPEEEEEEDVEEEEEEEEDVARRYPRRRTSARRLSGSTRSRVSSQRGRNARRVFQEEEDHDDQDQDELEETQVDDEDGEGDYENEQDRYEEDGDAEDGDADAVSDEAAVKSLLSLSAANRKTRPLANAPTTVIGFNGGERHALHPRPMGAVDGVGDAAEFSSNGHRSGQHYPHRHGFDHGGAVLSMSSTGNFSVASSVPSSTLSSSVSNVFSPLSRSYGPMTSTSSFGGSAANITGAGARAANGGGGAHMMSPLNGSLASLASFGGLASNMGSFGGPGSQSMSMGSFVAGSMGSMSGMSSMRGMGPTGMEDFSSNMHILSSLRTSSLRESSVRESSGRERESSVRDSSRGRDLDDKDRREREQLRAGVTPGDEDGEGDRDADADADVDAEGEKDGEGEADADADADADADGDAEMDDEQGAATASVPGRSARVNGHGHENGNGAVVYEARAGSPYGSSSGVNGINGAPDNKSKTYQETNSLPKMTTTNASNGSFSNDMIVDRDNNLDTVNGNGIACVSIKHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIY2</accession>
    <name>A0A8H5FIY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000200">
        <property type="protein sequence ID" value="KAF5338113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIY2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="114" mass="12390" checksum="97E7173120B9342F" modified="2022-01-19" version="1">MIFDGILTANENTVLIIAFCVLAFGALAFMGLFVLYTQTTNDDVFGDDTIAFGYVKARFIAADPGNEAAYTNVTVSTPRPMNLSSAMDRLSATRCDRDADQRLFEALKDSGFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLN6</accession>
    <name>A0A8H5FLN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000166">
        <property type="protein sequence ID" value="KAF5341351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLN6"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5341351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="310" mass="35027" checksum="B5A09F4674693191" modified="2022-01-19" version="1">MLPAVANRVVVYYQTHYFRDGTFVSPLPLIGYVTHLILAAFHLNMFHIGPDIVHLNDFMPSDPYFYPLWPEINMVQGNGTKVLGMLGGAAPGTYECLVDSLFDIYYPPLAEVIRTYNLDGMDLDVEQALSPQTIQRIIRTLKADFGDDFIITLAPVASALTRQGNLSGFDYIDLEHEMGDYIDWYNVQFYSGFGSFFPEDQYIDIIEYDQGIDASRVTATVLTNPDNGGGYIDISAVLHSIRNLMEEFGTGWGGVGGWEYFNSLPVVDEPWAWAETVHDVMHEQKRVMEARGDPKGAVERKRVASRFFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN90</accession>
    <name>A0A8H5FN90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN90"/>
    <dbReference type="OrthoDB" id="3259206at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="376" mass="42034" checksum="2DBAECBE9FF24D61" modified="2022-01-19" version="1">MSSNTCEIQFLEVVIHTVGQAIIIVSVVYMVYGVYLAVTLLSMHVLVSRGIRNSRARMILFIIAMLQLLVSTSYAVITVVFDGFIFLRGKATVEWFTNWMYTATQLGIVNTFLMRLNFLFSDGIMVWRTWVLYPHNKTVRIVLVLCMIISTVANFVDAGISTARALHMMEQRTMIGMVDFPGDQALIMALPLLVTNAVCTFLISYKTWCHRQDVKKNLTASGTPQTKAGKILMLLVESGMIYCAIWVAYVIVQVLYSDFESQTGTLWTIANTFTFVVPMLAALFPMFIILIAALEDPQNSTNGSNINIHIPSSLTISMQFAIAKSYDDHSASEYDSEHQNSNRISVLEFPRKDDQYDLEAGGGGFDESKKEPSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRZ8</accession>
    <name>A0A8H5FRZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRZ8"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="360"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="885" mass="99734" checksum="804D62DCDB77F480" modified="2022-01-19" version="1">MPVMNVRGKKFDVSQDYCKTCTFKPLLEPVGDSETMPNNICSSCLNAGVPCTHNKEQQNTLKKRGLKPGAIQAVPSQPVHILVANILKGTPFEPFSIPEDKEAIRKILVKLASRIQELEKDQKFAAYDNWIEGLRDEFTSSNATFLPSGQVPNAPEPSQPVEDSEAVENLSKELAQFSFGPPKETHFGESSNIMLMKVALDHRKQLSGLNLPDWNSVFAHVRRPEFWGTNRYWYPIAPPQPKASMYDFPPVNDLHRFIDIYFLERESYMPLLHRPTFEKSIRQGLHHRDPSFGAVVLAICAHGEKLYSTSSLEDNPGYRWINQIHLDGFVFQETLALEHLQVYCLMIWYLNSISKGINNVWLLTGIAIRRAQEKGAHRRYFTSSTQPTIEGELWKRAFWNLMIIDMMISAFFGRPRAISNQDFDADHLIECDDEYWEPEDGSQRFVQPAGKPSKISYWNAYLRLMEIFGFALLTIYSVRKSELGNKMGIGNIEWYEKAVMGIDSALNQWLGSMPEHLLWEKQNPDPIFFTQSTLLYSWYYWIQISVHRRFIPRPMDGSGILSFPSLAICTNAARSCLRVCEAYVKRESRYYSQLTIVIFNSATVLALNLIRSTKLKVRFDARKEMMDIHKCIELLRLFETTSRFAGRLTDVLNVMMYTSHLPTQSENAAGSSAVSCEGSSAASTTAQHPPQAQTFHPQPSAPNQPLHQFTSTNGDWGNATPAALPPSAFTTSLSTSNPTTLPFYSSELGGLPIHPSFSSFNNEPIGDFSEFSYPQAPAEANAALSPDVRQYSSLFDDGMGNNSGAGQNSSFMTASSGAFVLVISRFLFLEMKLTLDLPFSLSDPVPDMSQQNYSSVSQDWDTFMASVDKLLDTSAETTSFDPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSN0</accession>
    <name>A0A8H5FSN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSN0"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="519" mass="60751" checksum="AF4AA75AFF53D7B3" modified="2022-01-19" version="1">MLNHVSMQRLCNLLPILTIGAVLLFLSSTHLTPFKNYTQHFNGGGDDANPLNPIFQDLHPETSHHGSGLAKVKIPSPSTEQLEVKKYSPYCPPDKCAYGRWVPRNPRFTTYEELDRYINIYNKHGVDPGLRLVDPEPEPEPASGVKLTEEQKKQRVLEISNWVWEADFGEVIPFDIEEFVIRLLKSPGGIFVVGDSLTTHHFYTLHHRIFQSDLRLEPYNEGPLQGEGLAPQFRLDMNHPTCQELVKRAGIPLSRAQRPILTHIVAQSLVTPDELKKIFRAEWGYQHHHHYFTVNEWQAALAEMTKEREGERAKGVDEDSLVVISNGAHWSRVRLRGYVEETDYESFRRRIEHGYSEMIRVTMANLAPLSHTTLFFRSISPGHPICPQYRQPFSSIHEARNWSLQAGHDKPEPEEWDWDMFPSRNEKWREAIRNYEQERNEENDSVWNGRGARWVYLDFWPMDFQRIDAHTGYWDCLHYVLPFEHNQWTDMLFHRLVVETRLKESKREIQDDSDLDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTP9</accession>
    <name>A0A8H5FTP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTP9"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="153"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5348689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="459" mass="49946" checksum="AD807E988D88E3D3" modified="2022-01-19" version="1">MLRLLRFPTMPTLRSSTRATIATASATSTGTGEVVTAASSTVKRKITEITESESAPSPKGKGKKPRVTKAASSSNTQASTSDAQDAPSVRVIPEPGPQPILVPAKLTFSFEDAKKHLVTVDPRFQVLFDKLHCKPFEQLEQVHPFRALSTSILGQQISWLAARSIIHRFIRLYDPSLPEKVGDLKSEDKSPQSFYPTPHQVASTDVATLKSAGLSTRKAEYVIDLAQRFADGRLSTEKLLAASDEELAEMLIAVRGIGRWTVDMFAIFSLRRPDILPVGDLGVQRGLLRWILAAHSSTYTLGISPNKLSMIGKNDDVDSDDEDSGSTLPVIHEESQSTQDASEVTIPQDLSSVPPAAPAATPRKLGAGDTEVNIPSLPPTFTPSVKQSLTRVRHDQDYVPDPLPAGLTAASLKTRLDGKKKIKGAILTPQEMLDLTDKWRPYRSLGTYYMWALAESEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU09</accession>
    <name>A0A8H5FU09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU09"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034707301" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5349049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="40134" checksum="8D958D621CC24226" modified="2022-01-19" version="1">MISRQFVALATLATAVGAQQYHLSMDFSGPNFFEGFKYNESAIDSNNFGNVHFLGQDQALASNLTFVDSNGHAIIKVDNTTNGAGDITFGRNTVYLMSNDLMSIGSLLVFDANHIPFGCSVWPALFTQGQQWPEQGEIDIVEQVNRATKNQYSLHAGSTAGTCMQADNTNQTGTPTATPNNCTVVPENNQNTGCVVQDASDNSFGSGFNSNGGGVYATLWDENGITMWFWERNSVPSGIDTNPDTTKFSTPAAFFPASGCNPSTVFGPQIITLYIDICGAFAGNDQVFQQTCGSVAPNCSALVGDPANYADAYWDINYLRVFTTNTSTATVSPGQGPTATGGDSTSPSSGDNGGNSALSLSVSGTTMMSALALFLGVAALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU93</accession>
    <name>A0A8H5FU93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU93"/>
    <dbReference type="OrthoDB" id="2538110at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="102" mass="11436" checksum="BB324E92BB770BEC" modified="2022-01-19" version="1">MSRLADDDDSEGHALLDHHGYDEDVEDFPNSRIRSSHPVHNYPGSNSRSISGRFNPDDPWAVFHQPTPSPYSRTALLVFIGLMLWLGFRMRATLGEIGGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV83</accession>
    <name>A0A8H5FV83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV83"/>
    <dbReference type="OrthoDB" id="3050377at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5350396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="20605" checksum="93E88A8BD6658146" modified="2022-01-19" version="1">MHTSPVSCEQRMTTKRLSVVLSSCKMLVVINATKEIIVSGGVIGSLNILLNSGIGDAETLTNLGILSTLDLPSIGQNYTDQGIVDYIWIVNSTDPNNFLSQDKSVREGQLEQWEQNKTGPLADGALVTGCFFCLPDNASIFETVKDPSVGPNSAHIEMVFTSSNIGFPPEAIGNVTNFMLVSPNILTPTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYN4</accession>
    <name>A0A8H5FYN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYN4"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32137" checksum="245254EEDCFC7B1D" modified="2022-01-19" version="1">MSSDSNVPSAMSNPGTVPYPLPTSSRGAERHRLDDMHQGIARYMKRITYAPLQNPSRILELGSGTGAWTIKAAETYPAAQVTAADMSPLPNDLNLPSNVTFKQMNFLESFPFKPESFDVVHMRFVMMHLPEPQEVVSRLASLIRPGGWLLLEEPNHTLLDANNDIGPGVRELYKGYHEHMRRQGVDPQIGMRIRTLLEDSKEFSEVNETVIPFYVNPKSTSDPDLQEVGQILKYSMDGVYIGIMEKVGPAAGISPEIMRAWREEVNDPSKDLRLDMHMTWSRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYW0</accession>
    <name>A0A8H5FYW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYW0"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="573"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="107406" checksum="30E4FBF0951BFCA1" modified="2022-01-19" version="1">MDYDNYDAIIHYIWARTQNDAWFKPTEDNISAGVCLRVDQGQFRVFPYENKFLVPFEAAVRALNPLVAVKVRSAAVHAALANVTDDAEAIYLDLGTRIQVLETISELASADKEQCGAFVRDERILVVWSDDLDTIIDLCQDFETKLMKFVWRCRTNTSSSFITSGSIGSLGTVASDVALNNHVVFNDTIHEKTEAEAPVPVVPVSAKPKKSRSCWSWRLSSKDTSPPLASDVEKGEGYRQDRPIRLFAPFYGGLGAALSVFFVGSGVSMLLQEQRLDGTKAGLTRFALLASSPLLLCVSLFFALQVITNISFIIGPVAQYHENSRYYSAVKPGPVKELDGDGNGEKGRLPHITIELPVYKESLEETITPSVISLKKAMQTYARQGGTSSIFVHDDGLQLISSLEREKRIAFYANHGIGWVARPPHGSDGGVEGGEKFVRAGRFKKASNMNYGLALSLRMEEKIRELEAREGGEGGSKVQVHSRGQSTTTTYGTGTYGTGTYGGSRPTTATTIGTKPGSSSGLVPKDPNNNNSSSSLSLEDQALQLAIEEIYEENGKKWKPWACNARALRVGEVILIVDSDTIVPEDCFRDAARELYQCPDVAIIQHESDVMQVAHHYFENGISHFTRRINKCISMGCANGEVAPFVGHNAFLKWSAIQDAAFVDVDDPVDKKGREKKKIWSESNVSEDFDMALRLQIKGYIIRWATYSEGGFKEGVSLTVDDELNRWQKYACGCNELMFNPLISWWRLGPITKQLRIFIWSSAPVHYKITMMAYMFSYYGIAASAMLSLINYFLLGWAIDLDGYYMHSFEIWLACLVVFPGAGNVAYTVLEYRLGQRNILSSFLENVMWIPFFFFFFGGLSVHLSTALLAHLFSYNITWGATTKEVERSNFFLEVPKIWKRYWPVLIGCFITIAGMIVLSLEVIPAGWRIPGTSWAVILPLALVTAQHVVFPIVLNPWLMIFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZ18</accession>
    <name>A0A8H5FZ18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354491.1"/>
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    <dbReference type="Proteomes" id="UP000559256">
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    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26190" checksum="AF84E6F7E3434491" modified="2022-01-19" version="1">MFIFLLADHETTAHTIAYVLALLALYHNEQEKLFQHIKSILPDGPIPMKHAHALWKNWKSSTQVKGPIYILASKFQLTKSGHELECQNPLPNWCDADLYSVVELGKSTGLPIEFSDLEQSFLGWTMEHVVRLDYDLIEEGIDKCRNYFETNGVSEAEQSPIIAVLNFSRPDFPEILVLPMDRFEEKTKHWRAERARRICPSEIKKLDVEEIKEKVDEFEVGFFRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZH2</accession>
    <name>A0A8H5FZH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
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            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
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    </feature>
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            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="27366" checksum="BF0BF291C3D27420" modified="2022-01-19" version="1">MSEAQAPTETTPTNRERGRGRGKSRGGLGKYLRARGRGRGYGRPAEFHKRLVLEEEGEEELDEEEIAERQQKYSRRRLGTNADRYAESEPELDSDGEPIVEPEVDLSAFLEKQRLSEDPGSSTVAKDVEDDDVDHTLSQYSSKPVQATAADRKGKVQQVEWDDDLEEMMREKTSADATRDLKHRFREKSEKLRRKPVATTTRAQKQEASYVDAPPLPVPEDIKPKTQMEEMEDFLDELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G151</accession>
    <name>A0A8H5G151_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G151"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="118980" checksum="52E3DA51EF325660" modified="2022-01-19" version="1">MTRLIHGVNSLFLLYYHHLLLVSFFLMIRSNSDTTTTTSTYSPAPTSPFSSNLSIPSEPTSDETPDLGAFTAVLRAWSHLQPPPRVINSTLANAQQNLPSTSTSRALSSFSSATHSPNQNHPHLELESDSDLRDNKSTVWAHRRIASYLNHIGDTSTHTGTHTHTYTDTESQTDPDRDRPVSVFSSETIGEPEQDLQREHEDTDTRGLLVPIRDIDELDSSSYDNDIYNDDDDDDDDDGHRGQDQNRPNETQVVGERRSLPVSRMEYEPHYELDEEDDLDGRTPLNLDSFGDLGEQPSLGYFDEALKFIAAERERFTAQREAGVATGLTNGIEPRKRRRRKRTKTPRAHSTTRTTASSSTITRASKSTLSDIPGAVDDPDGDVDADADESSSSYDHNYSTSYSTSNYTSSSAAAIITFKSAPGTPGASRRRGRDRDPRQRQTHQLPSNPSQLATTSSGKQRRPLKHSRSTPQLRILQRDIDEDDDEVVESPRVAQLRALGRKLETLFPEDVDYLKRVRYTMLTGMSPTSAGKGNGLGAHAETVSGSGSGHGYGYGHLMSYPQAGHTAFNVNLKGGAGPGPVGGRGSPGDVVEGDAPGTGPGGIFGGFIDTRGSPPVASMSDTVQQASTSTNMGGRGRQEKEKEKEKEKEKEKEKEKEKEKEKEKVKVKDKDKSRAKKKVDEDEKLIHVFVDHSNILIGLINYLKRYPQKHPQYRDLLGGTTSTSNSASISGTPASGNASQHGGNGNNVVIPSGYPKPPKHLSHSALTLILERGRPVTRRVLVTSSPLYQPMESAAMLGYDVKVFARVPDYGDGLDRERDRERERENADKVGRVENGNGNGRRKTHKRSVSSGSFSGLTREASTSGTSGSGNDLSPKKSRRRAGSVNNGNSNSNTSNMNPNTAVRGVSGGGVLGRRKSHKRQTSGSNSTESEQGNGNLGARGFPQAFVRSLSGPASAVIASAPRGGSPSNAVTAATNMTITQAPTPQRIRYREQGVDELLQLKLHQVLAALDGPPPPGSTIVLVTGDGNAGQYNEDGFLGGVRTALKKGWKVELYAWEGGLSRAWNREFGEGSELGSGFRVIGLEQFGTELVEIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2Z4</accession>
    <name>A0A8H5G2Z4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_005875</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2Z4"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="87"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5357298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="41667" checksum="F21B341275B4E767" modified="2022-01-19" version="1">MSFAFLRTPLRRAVVQRSLPRAELRNQFRSSAIRRYTTAESSSNPPPPPKSNTALFVGIGAVVAAGGVAYYVFSDSDTVKSGTQIAKVKANFVPTKDDYQKVYNRISELLDADDYDDGSYGPVLVRLAWHSSGTYDKDTKTGGSNYATMRFEPESLHGANAGLHVARELMEKVKAEFPWISYGDLWTLGGVCALQEMGGPKIPWRPGRIDGTATEATPDGRLPDASQGGDHLRNIFYRMGFNDQEIVALSGAHALGRCHPDRSGFEGPWTFSPITLTNDFYKLLFDEKWVWRKWNGPKQLQDKKTQSLMMLPTDYVLVQDKSFKKYAKAYADDQDLFFKDFSNVVSRLFELGVPTQQFVTPEPWIMKNLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G393</accession>
    <name>A0A8H5G393_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G393"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5357475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="17778" checksum="9D0FAA090CCA8051" modified="2022-01-19" version="1">MEESWHNELCTRPTFDIITHMWQDSNKATDRPQVDKNRGLEVVLITSGILSHDSISANLICRTQTAVTLIRLLCSSKSSDEVDILALWCLNRICRNTEVVTNLLNLNIVSVIKELAVDGLLPPLAMYCLWTLIKSDAIADRMEPLDIIPYFMRHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3F8</accession>
    <name>A0A8H5G3F8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3F8"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="6">
        <location>
            <begin position="300"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="760"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5357671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="819" mass="90118" checksum="D2FEF1835E6D2113" modified="2022-01-19" version="1">MSKPASPTDTSPSPPNLTISQRTPTPPNIPSVVQSSTDDTHTQAGMRRRQSSGKVFDGAAGSGNGGQGIRDEVPSSQSVPTDAANVAKKLESVTGFDEGIDPAIAPSGQPGTSDNSFQRSLKHTRTEVDAGGTSSVSHNSIELQSFFVANKSDEGLLQHVSDRCRSQGNGDRTTNTSHRDDGNIPDRIGEPTLDDTIDEIGHGLSASPVHESSNRENKSGTDDPYQNTPPPQNTKSPKSSGYGGTGNQPQSTHQPTALNRFMMQSGPQASLYSDNRNYDYTKKYPADEFGQEVGEKARVWKVYLDEAEEYDREMLTGFRDTLDALLVFAALFSAVITVKSQLCSWSSKTCFFVPPGIPLLLAMLKTALVNLDSADASTADLWINGLFFGSLSLSLATALLSVLVKQWLQAYSSSLPTGNARERAKICQFRYAGLTDWKVPQIIGTLPIILHASLGLFMAGFSLYVSELQPSLCWIVVSVTAISFLMYLGSIVIPVIITIQCPYRIPLLFVPLNFIIFFPLQIGKCLWRRVKYYWQRRQRPWMSIPQWPSLPSNSIQAAEATFLKPNDIDEEEYDWNISLPHNPYTHHHSILADCIKWLQSLQSNDSMQDIVGQALHGIMKEHIIRGDDGKQYFCPALKCYINNLDLKLILSWILSTPQIGDKEYKSKLCKSLCTEWEKATENFEGFPRKELEGRLYDEAWCGNLQHVKTLIAMGTDVNAEGGFYGFALQPAAASGHLEIVRYLVEKGADVNAKGGHFGFALQAAAAWGHLEIVRYLVEKGADVNAQGGFWGSALNTAYAYSRSQITEYLESKGATRAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G518</accession>
    <name>A0A8H5G518_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gpr1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G518"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5358594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="23865" checksum="408B51C99F715A89" modified="2022-01-19" version="1">MPSTNSNDIEKNTVGRAEYGPGSADPVSYERYPSHIANPGPAGLFSFAATTFILSMYNVNTRGVTHPNVVVGMAIFGGGLTQFIAGMWEFPRGNVFGATAFSSYGAFWMSFATINIPASGIAAAYPTEEEMANALGIYLITWMMITIFFLMAVIRRSVCFSVLLTLLTIALGLLSAAEFTGSGAVQKAGGVFGIMTGLVAFYIGVGELLAAESTAIIRVPLGNRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7S3</accession>
    <name>A0A8H5G7S3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_013984</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7S3"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5359927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="598" mass="65294" checksum="C6598F57B903A05E" modified="2022-01-19" version="1">MCCLHWSLVCGGVEAQATKLRRRSPHILPTALRFLLASLISTDSPTTNTLSSNTNPNPFTNTHSFRLAHAHALTNDSRTIFRDFKGHGRGLRDGNDSGRGGGGSGGDTDAETLEALQDLYELQTSPLLTYRPPSYASIAAQARSRSRGSFSFHGEDDFDPSSFWLPETIPAPNVSDRYTLLTLAKMTQNTYFSPPTSGGSSSDWYDLGPQWNPNSTFSYGWEPDDDGFRGHVFVSSTNITSPGPDGQTYPSSPELVVLTIKGTSVPWIGGGPTMKRDKLNDNLLFSCCCARVGPTWSTVCPCYDGFNKTEGSFVCRQGCVEQALMEESLFYSVGVNLYNNLTLLYPHSTIWVTGHSLGGSLASLLGQTFGAPVVAFDAPGERMASRRLHLPEIPWGGEEEDMPRSRAKSRLSEGMKGKRSRLSGNVPIPLGQCTGVTSTCASAGYALESRCHVGRKIVYDTVSKLGWSSNVQNHPVRVVIDNILAKNDTDWGKGKGEGEWEGGENESSQEGGFGFGWPWGGGGKDEDKDEGRPAWWRDVPEVVWEDEDLDVVVEEGIRMKEGQHGGEMYPRLFGRMRIVSSLCSRARVEVGTAWSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G845</accession>
    <name>A0A8H5G845_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G845"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15498" checksum="9E3FDFF2C84D2630" modified="2022-01-19" version="1">MHKRMNVADQTISGTNVEVIGVLFATIWASSAQPETEVHHSSYKTSSSSRYNSNNNASGGTMSRVQIGVSVTRQTAIIPTITSGQTLRSSTTAKDSEAETAIEIVEIEMSSLKELKPEREDSSIAPSFEKDQEVPRSVIPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAG6</accession>
    <name>A0A8H5GAG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_006197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAG6"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5361384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="37902" checksum="147EF6F6C824C6C5" modified="2022-01-19" version="1">MTNYTIPATQKAAVISKAGGTVEIKTDHPVRAQKDLLPGECLVKLDCSGACHTDLHAAAGDWPIPAKLPLIGGHEGVGTVVAIGDNTTNSPVKLGDRVGIKWLADSCLNCEQCRKGREQNCDQAKLSGFTVDGTFQEYVVSYVNHVTLIPEGIPSDEAASVLCAGVTVYRAIKHSQTEAGDWIVLPGAGGGLGHLAVQYARVRGLRVIAVDTGADKKELCLKLGADKWIDFKETKDLVGEIKAITGGAGAHSAVVTSASATGYTQAVDYLRPGGTLMAVGLPGDAKLEASIFWTVLKNVSVIGSYVGNRQDAREAIDIAARGQVKVHFATRPLSELKDVYEGMKEGKIAGRIVLDMSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDV3</accession>
    <name>A0A8H5GDV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDV3"/>
    <dbReference type="OrthoDB" id="3229610at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="41052" checksum="0AFE5EF931733FF0" modified="2022-01-19" version="1">MMIPLSAIRVLRVAATITHSIALISTSYRLFYRLRRRRFSWDDGWAFMAFLADIFTLVTLWIFAYLNVNFRFARLSLASTLLSMLPKGRVRKASLLSIVLFTLFWASLYGWKVSVCEDDDDDYGSSLETTLYEFCDAGKVAGALEIVADTASCVCLILTGAYILWHMKLHSKERQMIVFMFSGTIFTAMAALARSYSILSTEDTLEAFTGHFEAAISLIVCNVVVVMAGIYGMLYQSRDSSEPPTDVERSPNEKGLHQVDRITHDTDSGTGRPSTLTFTEVDSFESPNSQAIHSDPSPSHSFSSHTRSPSPISVHSVSRSSERQHRSRAGDPNPRTSTSSSQEYYTESEPCSGSVIIILDTDSSGSELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDY5</accession>
    <name>A0A8H5GDY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDY5"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5363168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="27523" checksum="669070CFF4A0D38D" modified="2022-01-19" version="1">MSAITCNKQIPSITLKTELIGKVTGRKIDANTLIDSGAEGIIINGQFTQKHQLTLLPIKKPFPVRNVDGSENTMGWVREYTIQNLRIYSQNGEAYHEEKAEFYVTDIGDHDIILGTDWLEEHNPAIDWSDSRVDMTRCPETCITAKPPVLHLKTQSLKSTVVDPRTHHKDYQVRWLEPIGQFKPVAQPKVAGRRCRIPIRSFHRSSEVTAIFTEDDYGRDTIPERWEQDVMEELLGKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHN7</accession>
    <name>A0A8H5GHN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHN7"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="33966" checksum="B6502E085045E4E0" modified="2022-01-19" version="1">MSYNDDSYGSSNNDSYGSGRRGGDSFGSNTDTYGSSNNDTYGSGGRGGQDTYGSSNNDPYGSSGRGGGGYGSSNNRDEDSFSGNRDGDYNSSSRNDSSNTYGSSNRDNSDSYGSSDNTYGSSDRNTSDSYSSNKDSYGSGANRGDSDSYNSSSQSNTYGSSQGRDTSYGSSNRDDSNSYSSGQSNTYGSGNRDDTNTYSSPQSNTYGSSNRDDSNSSNTYGSSNRDNSKPYGSGGRDNSDSYGSSGRDDFDSSNQNRDNNSYGSGNQSSYGSSGDSAYNTSSKTAGSHNDMVDKGISFAAQKAGYNIDESTADKIGDGIRKFTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHP2</accession>
    <name>A0A8H5GHP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHP2"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5365251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="560" mass="63502" checksum="6C8385D7C23798E1" modified="2022-01-19" version="1">MTATCYADDSSDPYRQKTSKKKSCTNCRHRKKKCDRGRPSCKNCLESANFKDCEYEDGQVTRTQQLEMEIARLKSLLSCYEQLHGHLPESSLSESAPQAPSSGEALVGSRSGSSSPSGSEFPDPYDSDMIDHDSMILTIPRHEDHDIPIFERTQYQIFFNHSSHLRFFLDPSRLYSMLWPSDEAPEVQSYPDVHSSLVDAMHLWSVHISDSGADRSVEGRLLFRVITDLSVCNLSADDPIVLPYKVVHLIQAHVLLAQYFFQSGRVLEGKYYAHGALSLVLSAGLHLEAGYMGTGNDGFQLRLVAARDQIEQNDRNRAFWDSLSLTNVWSTATQLSPFSNRHFWSNEVAIHDVPLSANDLDPDFFCPPFPLDKAGFLWEQATLLVTRNRSSITGAQPHGFSRSFDLLEGTIHKELEKLPDMALQDQLPHQTQMLIQTMLHMALIELHSPFAGIQFKSYLQIGSSLKRIVDLAIDPQILDQEWHPLDPVFAVIWTKVIDALISHIRWHRAQEQSREEQTEEHFDLVISLMSLLTVLRELSMQSNLMRLAVTKGDDIYRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHT0</accession>
    <name>A0A8H5GHT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_005386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHT0"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="764"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="939"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="646"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="808"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1082"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121706" checksum="47CB5A7A9DBAFB7C" modified="2022-01-19" version="1">MVRHNPVSSLARNHRFNNKSRLKIIRGDFDSDNLVSNEDEEKDRWQQSIAGVDKEDVNEHHLLAALRAADAVTKKEEKAAYIPTPDSNGIVHNYETLYPTNRWKDPHSYVQSSLTVEESASAALHGGFTYYMDERDKEWLDRNNEEARGEGTSAQGASTRRSSTSSRSGKGKETDSDELRAEPVVMNEDEFELVMGLFEKIAHENTEFLYHALQNGMPFPPFSDYEPTFSSSLSPTTFALFNPPPWLPSPNQLVRIARAVYPHWKERRLERKGHRIAPVLNFDEEDTLNESYVCFRRLEAKALRKTRVQQVSYTDKLVRLQSEFGSAFELAKTMLLREQAKMEDMKQDQAIWALRARLVDLKSRNPTLFDAKDDEALLFDKERVLKKRKAEAASSVKETSKPEAGPRAQSQQPQSLRSDLKPPETRAREIQQIVEAAVAKQKEEDSQWENILDSGYVNSYVSVPSRHFKQLSMTKSSSPTPSSLSSDSGRPISSNGRQSLRTRVGRGGRLHVDRRLTIRVPPVAPRSSRHPAIVDSDDEQDTDNSAMDVDEDDVDQNAYEEADRRLTERWRFDSDDSMPVGITDEHDRMLIDDYGFKYLKHSMSLLGDTDFGDLSTDPTLTLPGADGKTETVTPFRLGMFSILKPLPLSSSTPSSSEPTLARSASTPRSQPVSSPTSSVKPVSILQRQESVMRISGNGGLPLRSTSVAATPSATSPSPTSSPPKPQATATSASSPPAQQQPLHQPRPIVNGIHRAAMTMPHLEVTKPTSMSPPVVPASTPSINRISTPTTSDAQMQSANVDNAGQTHTRPQSQQSQRQAPSATSSPHPSHLSPHQVPQQLHRSPSLNSPHIQQSRTATPSAASPHQQARTPTPSQTPNPRTVVNGHVHHPYSSSPLTTTTHVPGYAIPYSHLSAGYGRQQTANVVNGVKAGYNSASPVATPTPTENAANPNGSTGADGNIATNGAATHIASPQELSILQQLHHMQLRGLELQGLQSTRYLQSLQAQGFNLSALGLQNPQNTQGPHVQSYQNLPQNMQQTNGQGQGSGAGAYNAQAQFQMQLQMLQSLTNMGHGKMPVARPRQGQPYQQQQHVSSQNQLQGQAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI97</accession>
    <name>A0A8H5GI97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI97"/>
    <dbReference type="OrthoDB" id="3070764at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="322" mass="36090" checksum="90CF459AFB094555" modified="2022-01-19" version="1">MSTITPPSETYALMLLPLKQGYPLWIPEPNDALPKEYRNEGVCIGDVGFITLDGAFSFLFNICLEKDHPINQWRGVPQGFCPLQLESRTGAVLLFSGAASRTDYPNTIFREYGARNAECWYKYVRDTLGIGKNSLYLLTGYDKTRCSETAAFSDPSGSKAQPVCLQLRSDNGALTLSDSSLSQNNVSGRRVPQNNSINQSVFIRGFKLCCAAEVDATETMHSSEKYQPSDVINKHILDTVRPLSRVDMPLIHTFPIPEQHTDMNVALTHDSQWCSVLTEEDSQMPDSDSLITRVRERYHVRFSDGSAYLHNTSEFSPGSRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIA4</accession>
    <name>A0A8H5GIA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_005453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1441"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1562"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1811"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1878"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2075"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2190"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2233"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
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        <location>
            <begin position="587"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="647"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="670"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="684"/>
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        </location>
    </feature>
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        <location>
            <begin position="1374"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1574"/>
            <end position="1588"/>
        </location>
    </feature>
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        <location>
            <begin position="1811"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1899"/>
            <end position="1914"/>
        </location>
    </feature>
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        <location>
            <begin position="1933"/>
            <end position="1943"/>
        </location>
    </feature>
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        <location>
            <begin position="2137"/>
            <end position="2151"/>
        </location>
    </feature>
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        <location>
            <begin position="2153"/>
            <end position="2164"/>
        </location>
    </feature>
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        <location>
            <begin position="2190"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2273"/>
            <end position="2288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2358" mass="256732" checksum="ED389A1279FF059F" modified="2022-01-19" version="1">MVYKGSQEKVAVNSRNLFKILCSKLLLIFALVNFAIQLPLLIQVSLINHDLANSPLSSPSALVGSCGFSLSVFNRIDTEGFATSINEKLNQDNDAIVTMVYSQFATLLVVIVSSFSDSFSPYFSICSFILIQIMWTSVQIGETEISDGNCQTSASYSFLGVGDRILLENTKTDARTLTRHRARTLTKGAENLFHISAYLWIGVSLLFAAGVDVTSMSVSMVLVVVSLSVTWFRLGWLSIHQRSRSDPLLFFLVGITIILVFATSRSIIQDFSSWPFYIASLALSIVLAILSHVVAVLAMWYSRTNGDHLELPERPNETSFLPVTRPFSSNAFATPPSNTEIPVVSPPFSPPPIVPPSMTRPGCVQSQVMNQANLSASEVLPQSTISEALRNTVRIESQLSSPPPPSINPSTRPSTFATRPNGLAQTSVMRRPSGRREQDSSIDQTGSVSASQAVPSTPPLPFSLPSLSPPTPLTLLPVPPPPPLIILPLIVPPPPSLPQPDSPTNSDASSQRPAVPSQTIFNPPSRPQTPPSQANTTIPPSSFRYFGSSSSSSSSSRRTSRAPPDVPVSPTRRDTLASDVSFETLPSYRSRSNTPVTSVPPQLPFSFNVPPLPPLPPNYPSLPSTPAQFLTRRPTNSSVRTFATLPSYRSMTTPTGSDSGSETGDFTESSDDRELLSREEEQLPISNGRRSSQRSIMNGGNMTPGSLQYGLRKEAVEKANEPFDEPDPKSQFDWHTLNGNVLEVSLSSSLILLPYRSGTCLVPSKKFWLTYIEWGKKYGGSGIELTRVLIPIRAILDSGDLIHFTRFGKHYLVLNSLQAARDILDKQTRITSDRANAQLDRISYFEEFITFQPYSDKWRKSRRLFHQIFRADATSQFRPIQTRQIYDFVESLRSSKYTLKDQIATVSQKIMFEAIYGLEISSNREEMPANNRELIDIDVGSDSIFTPGWDGFKYIPFIQYLPSWFPNGQLIAAHHVLGKMTQDGVNKPWDAVQEKIAHGDHSSLIANLLSGIDPENREEIHTIKWFGFTCVVVAADTTMSAISTFFLAMSLYPHVQSKGQEELNTVLGKGRMPTFDDRPSLPFIEAIFREVMRWHPALPMGVAHDSLEDIIYEGYYIPKGTSIYANIWAMTHDASVYKDPDQFIPERHLRNDGHFDNINSILAYGFGRRVCVGRYMANDTIWLAIAATLAAVEISSLPNENVEDYFTDGSLCSPESNTLNCLTEGRPPSFLPSTMLIRLLPVPSQPTVLFKLTFENLPHHLVYPSSWANQLAALSCDDLEVPELVHALDKAVGTQSILEEVTFDLVHSKIKCVFVDGEVEEWAFGTCLDRSRGPADSFHVPKEYDSDSDAVAAKLDVTRRLESVLADVNESAAEMDREKKREEERLRLKKEEEEKQRTQQQKEENGVVSAVAPTDASGKKKHKKNKSMLLNLVSAILPMSLNSPADPKSPRLMRSPKASSLPSSPVHSRSPSPSRSPRISSVQSESAKSDAGCSSAPASLSRASSLSAMIEYSRGDIKAFAGWNRRRRGRRPFSTSFADLPVDIAAEETQSDGALTANVSAAHTPEASEHSTNVEDSIPNSENPSTSPKETEPPIVVVAPPPAPPLTPRALRRRARSTLVDTFRMYIIPELTRRVRCGQYFSTALPTSPSISMVNSATQSTLGSSTGLTIATSASSTNVISTGSSNSDSVYTNPASGLSAPVPTIPLYHPNNVGGDSILYYVWVVGSMMKRVEARIGEVVREAREEMERLEMGGVSLRGSFSSVSSLDSLYHTAVTTISASSSAAQSPTTATPPIYHEGVVGVASAVASPFGAGNSSSEGSSKESLTSTSEATGSGSTEYESDTDTDGSSLHTPTGVVFQDPFVASDSLQMSAFGTEDMEGYKPHNSKSSPSSDPPAYSPSDSTSSASLNSPTLNHQNVNQFTFDDPSQETPTPAPPPVPTQPLSPQLTSLLSQHTQLTALHTHLHHLLILAHARVSSASADAGQREVMLEVRGRRRAWLNGSYRLHNRIQGTLVSGTPTSPTSLTNTTVLSRAGIAMATTSHTSPLGRYSWSSDEWDCDPFAYLELSLLPYRRRSSSDKSTPVSPIGSGPTSPFLECYPNPFESEGEGLDGGASYGVGANAHRKKSSISETTLLPVEEDDESEGEGDGEESGLGSSSGPISGSEFHHQTHRVKLNFGVSLYRHIQFDVDDASSDEDEDSERDSGEGGTGVDEDDEDLLRDIDALVDVELDVPEDRDEMPFEQGGVHKHPSGVSEPVLTIQKSLTKGKEQEESSASSISVSPTSSTKSVGPNLGPNLLVPGHDFTLAMDAVDIDVADNIDNVIDPLDGLPPRRKSIAMMAAANSMKMSQNEVINALAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJC6</accession>
    <name>A0A8H5GJC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJC6"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36450" checksum="B538D46DAB0A2D4F" modified="2022-01-19" version="1">MFCSSCGGIKPYRSRCHLGNVSTPINSMLRSFSFSPSSALQIQRDVENDMRRFDWEISQLRSRLLYLEEQQDLLTKHDEELKSLSAPIRRLPVELLTRIFLAVCDGHPITFAARVESIGHLPFTLASVCGSGWRQIVIDIPRLWSNLEIPYETDPSIHSRLEKPLRLCLVRSKSHALSVGLWDGEKSPLVRQLVEESARWQHATIADLLEVEFPSLASGKSFPLLETLETRHYAEEDLDQHTFGDPHLFLFRSAPRLHSLKTTKLPPPDELRAFTPRNQITNLEIICRTSIYNFEGFIYQRELHNFPNLKSWFLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKA2</accession>
    <name>A0A8H5GKA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKA2"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034979042" evidence="2">
        <location>
            <begin position="30"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="589" mass="65151" checksum="C607B331635A80AB" modified="2022-01-19" version="1">MYRPCFRPLAAQLALLFLLIATLTPIAFASTNFVQCLTDLQQNYSSLEGGRDNQGRPVSMSNATAVSYELCVEHCGSGPEAFSWSAFSQEFSSWLLPWLALISQLPFGSHDKLDNFTSMLLAVGSPTLAAYSVMITVLNSRWLTRRFNSISYPNVQTAIRVLSSLQQAPIRINRLHHELLPSLIVLPENDQWWETLKDHLDYTHTWSLSAAASMAWTGIAYIFTIVDSFTADLSTSQLIDITGQGVGSVWLWLLPIVFTWLQISPKCDSRRVYKAMKRANDVAYSATDDPDIKAVLASSRGSDRALDLQVEDHALNADERCTAPIFNYSRVFSWAAVVEEVDSCLQVAAYRAAHFEPVNREIEWVESERSRSIQDVNRQGTALQVQNYCRYFPGLEPRRCSSAIWPRVFIASFMALFLQWGTTGAALLIVFLTPTRGLGCRSTSYLAYASLSTVAWALFLLSSILSHYSSSGIDLDLENGRHRRFRSSIAVQVSIALRLLGKIIATINAVGIIVTNIFQISGFFDRCYCNSSAMSLGVAKAYNVIMLGGSEISSLRGVWIGGTVLALGSAGMFVLVLDLLINPSSPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKB0</accession>
    <name>A0A8H5GKB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKB0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5366300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="307" mass="32992" checksum="44EABE4AE78983C0" modified="2022-01-19" version="1">MDLLQFPEHSTELQEPESRQFQKDRLFVGNLASTVDEYSLLQLFTKYGKVTKFDFLFHKSGPLKGKPRGYAFIQYANEDDAKKALTSAHDKLFRGRKLAVTHANQAPLDTYGSSSGSRPRKGMMESGRPTTLSMLKSGGKHSEDTSNKIAMLEAKLRQMESSKPSSSNEASSSASTSTLPSHPSLPLKPPPQSSGAPPPTKPKSIPTTSSSTLLPSTISRNNSSNFIPSSSSSKPLPNIKSKPNPGSSTTTTMASTKSKGGLAGVKIVKKGKEKDKEEKDVSSATTAMMIDESGSGDNGETMKENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKJ3</accession>
    <name>A0A8H5GKJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKJ3"/>
    <dbReference type="OrthoDB" id="3263055at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17273" checksum="A370A0E7E3A623A2" modified="2022-01-19" version="1">MIILFQRAKTGFKRTTDLLNRLILFSVNTGLPTSLTSIITVVLLEAAPGTFIYIFYHDRTVYTNCLLITLNGREQIRNASQSTSTGEFGMSIPLEISNRRTNVGNNATIDNTANHGTKDPIAIRINQETMENFDDAKPAGTSEEHFHQPHSYGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKL3</accession>
    <name>A0A8H5GKL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKL3"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="150"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="57846" checksum="79D2EBC02BCF5604" modified="2022-01-19" version="1">MPGPLVTINKHTTSSNPRPHILYTVQVTQNGKHSVVDRRYSEFVALHDALGVKDTSLPPKRILVTSFIPSAWLDDTLIGERKSGLTDYLSNVLQHSKYKDHEALQNFLSPEVSQPQRFNAEDAVPSTLSRKAALDLLNTQSGDVQADATFIAAAYYPDWSADSFPPENLNYSKFDILFFAFATPSASAGLSWDSGSRTILQRLVTSAKNSGRGTRIVLSVGGWGGSTNFSSAVSSSANRSTFVNALVGAVNQFGLDGIDIDWEYPNSVGAGNPHSPSDAANFLKLLTSLRSALGSSKIISAAVPHLPWIGSNGSPLTDISAYAAQMTYINIMNYDVWGASSTPGPNAPLGNLCGTSSQPQASAQAALAQWKAAGAPANKLLLGLPLYGYVSNSKKTTLTGSFAPSEDMVLIQQADTDGKNFLNGAHARARVLPVAKQAANADLRGWYGQQIPFSSIVASGALVKKSDGTYGEGGGFTMGWDDCSDTPFLFNTAQSTVVTYDDTFSLGDKATFARQNGMAGCFTWSLDQDDGVTLQNAIRAGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLR1</accession>
    <name>A0A8H5GLR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLR1"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="116" mass="12816" checksum="E285B57B1B7CA119" modified="2022-01-19" version="1">MEPDEKEEEQKKVGAQSALPKITHAGYASLELIRYFTCGPDEVRAWTIRKGTKAPQAAGVIHSDFENKFVCGEIMSYDDLKEHGSEPAVKAAGKLRQQGKPYEMVDGDIAYWKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLX7</accession>
    <name>A0A8H5GLX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLX7"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034788809" evidence="2">
        <location>
            <begin position="27"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="435" mass="46101" checksum="EE72785616CFC64A" modified="2022-01-19" version="1">MSMSAPSTRLILSFIAILSVSYSVTGAPATKRGIQHDPFPFFPGFDIQAVADLSEQLPSHSWEYGFASEAILEIYNPELSVYGSNPFPPLVIDPSSVKALAYAQSKIQLNLSPNAGANVLIDGDGATGDPASLGLSATLLGLSNSTYTKAAELTMGYLVGSAPRWSNGAISHRADVAELWSDHIYMAPPFLAYYAAVTLNSTLLREAVHQCSLYRDVLVASASNPSVNANLTNAEKAELNGLWHHIIGPQSTDLGLWSTGNGWAAGGITRVLATVMKAPVVLTLGWKDEAVSTLKAILKEILDPLVSYQEITVDPFNGFLRNYLDDRNGTETGGHGFGEISGSSMLAAVVYRLAVLAPEIVTPSSPYLAFAESIRTTIGSGNHVSADGLVAPTADPLCWQCTVPFTSGSPEGQSFVVAMYAGWRDCVLAGICPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLY8</accession>
    <name>A0A8H5GLY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLY8"/>
    <dbReference type="OrthoDB" id="3048530at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33711" checksum="ADEDBC2B6DCB5BF6" modified="2022-01-19" version="1">MQAAEVVATSPAVKRLLKRRLNNLNVKPRIRKRKVQVNKLAVAENERDPEEEIYFAVEDFEQPSMEVFVQGKGRLPPNSIVHRDVVEQFLKHRPEEKGKRLVIAARLFDDLRVTYPTINRSSQQVECIMDNGSQIVSMNTSVAAGLNLAWDPDLVIHMESANSTVSPTRGLARNVPFKFSDVKAYLQVHIMDDCPYQVLLGRPFDVLCETSVKNTKEGGQFITVHDPNSDRRCTIPTYARGQKPRILPPLVEKFVDQETGEEVPLPLEDSEGVKEEEKKEESKGENPESNFQGSLMNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN04</accession>
    <name>A0A8H5GN04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN04"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="559"/>
            <end position="560"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="650" mass="72344" checksum="039CA7A30C2E520D" modified="2022-01-19" version="1">MGHPEEVDVIVAGGGPAGCVVAGRLAFADPNLKVMLIEGGANNRDDPWVYRPGIYVRNMQRDGINEKATFYTDTMKSSHLRDRQSIVPCANILGGGSSINFQMYTRASASDWDDFKTEGWTAQDLLPLMKRLENYQKPVNNDRHGYDGPIAISNGGSVTALAHDFLRASDTVGIPFSDDIQDLDTAHASEIWAKYINRHTGRRSDAATAYVHSVMDVQSNLYLRCNARVNRVIFEGNKAVGVAYVPARNRAHNGQLRETIVKARKLVVLSSGTLGTPQILERSGVGDAKLLQKLDIKTVSDLPGVGEQYQDHYTTLSIYRASQETFTLDDFLRGDPDVRKEIFQEWEISPEKARLSSNAIDAGFKIRPTEEELKEMGPEFNELWNTYFKDKPDKPVMFGSIVSGAYADHALLPPGKYFTMFQYLEYPASRGKIHIQSANPYVEPFFDSGFMNHKADFAPIRWSYKVTREVARRMDAFRGELTSHHPHFHPGSPAATRDIDIKTAKQILPEGFTVGIHMGTWHRASEPYDASKVHEDIKYTKEDDAAIDDWIADHVETTWHSLGTCAMKPREEGGVVDKNLNVFGTENLKVVDLSICPDNLGTNTYSSALLVGEKGADLAAQQLNVKIKTPHAPVPHAPVPFGRPATQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN20</accession>
    <name>A0A8H5GN20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN20"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="624" mass="69440" checksum="77D61CA59FF53FFC" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTLPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGEHTRTDVWDTAPTSPSSPPSTSTSSVALSVPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVICHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIYYIEESDAIELIEKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGSAQRSDKSKGERANAAAPFQKPSDVKKDRKCFNCNKMGHTTLTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWIQSISSSDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLRLAGDMRVEIRKDNARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTTETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN21</accession>
    <name>A0A8H5GN21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN21"/>
    <dbReference type="OrthoDB" id="2552978at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="352" mass="40156" checksum="989E8205A046C265" modified="2022-01-19" version="1">MSSRKRKHPNRNRSQRYRNEPGGSQTRIHEEIVFTPDPVLFIQAHEADVIRGPKGRVAAQSLEVKRKDAQDEWEIGSGLIRWGGDAVIPQGFPDDDNEDSAWPSTSTSEGIWVDRYDIRLLLDALPFPTSHAEPRPNSPSGWSDLPSDSEDMFFLSPMEIEDFHREKRRKLMERAQEERLKARMAEDGESVEQEDVWGGSDEEPDESQKEIMRRTANSILTSPNPAQLEMRILANHGGDKRFAFLRGRWKRSWEVVKGLRKLEMRKEQAEKEEEQKKNKGLGFLADYGDSDDSTFDDGDPAEDTRNEEAAGAQTEGMIEQPPPSVPAQDDEAAMQARRARAKEWMEKRKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNY6</accession>
    <name>A0A8H5GNY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNY6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="62441" checksum="248F5457895894D5" modified="2022-01-19" version="1">MEEGDIMEKGDIMEEGDVMEEGDYVCDREPSNSYMSSGSTAVPSMFSASTAVPTEKEEDFDFEEGYNVGATSVSSPLTPRTPLSNSSLSLAPSDSASQNGPFRFRRGSSSTTLSTESSAESTSSKRALSKLVRATESYLDYLSRIPCNNPEEEAEPAEPQAIQFTRGLGAVQVYLDEVVKPSIQALFKELPRDVQLEVQSAYPDADPDLALAHFDSEAVLQYVPSGVPQYTAAVTARNFQMYTEAREILALDSKDEKEDENDRMSILMMAQILTKYSEIRASPHWYSLNEEQVSTSFRQMADDVWTSYDGRYSTFKSNFLPSQTSPCVKTVIPSTARNALRLDSVDPTAYMEPDHLQTYKLEIDCANMTADQYNEAKRLVDLINFYGTKTPVECKPRTLIIRLIPFVQEFKQKNGNLLHAIYQLTQDLMIAASINTLLDLPFPSYGSAAAPQGCVFYSAKAEIVKTTPYNYLSFEVRPLKNLAQLSKVVNQDPIVNGNYDSGIANLENWLYYANFLYNQKAWFLDNVVATIKERNKADPHWPINKLRTRSFGLKPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP33</accession>
    <name>A0A8H5GP33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Myosin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_002195</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="38"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="20">
        <location>
            <begin position="777"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="1063"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="952"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1123"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1170"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1124"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1137"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1190"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1211"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1255"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5368396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1288" mass="140922" checksum="95766263AE790754" modified="2022-01-19" version="1">MAISKKAGKKAAPAAKKGGAPGKVAKADWKEGFKKKQVGVSDMTLLTTISNESINENLQKRWTTGEIYTYIGAVLISVNPFRDLGIYTDDTLEKYRGKNRLEVPPHVFAIAESAYYNMNAYHENQCVIISGESGAGKTEAAKRIMQYIAAVSGGQDNSIQEIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIMFNSNGEPVGARITNYLLEKGRVVGQVENERNFHIFYQFTKAASDEQREMFGLQGPEAYAYTSLSNCLEVQDIDDEKDYGDTIRAMQVIGLSDQEQSDIFRMLAIILWLGNVQFAEDDSGNSVVSDTGVTDFVAYLMEVDSALVQKVLTMRVMETQRGGRRGSVYDVPMNPAQASSARDALAKGIYNNLFEWIVSRINISMKPRSAHAQVVGILDIFGFEIFEDNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIKWTPIKYFNNKIVCDLIEERRPPGIFAALNDACATAHADPTAADNSFIQRTAGLAANAHFEARGAQFLVKHYAGDVMYNVQGMTDKNKDSLLKDLLDLIGTSGNQFLQTLFPDRPDPNSKKRPPTAGDRIKAGASAGALVENLMKAQPSYIRTIKPNQNRSSSEYDTKAILHQIKYLGLQENIRVRRAGFAYRNTFEKMVERFYLLSPKTSYAGDYIWSGDAKSGCEQILKDTGIAKEEWQMGVTKAFIKNPETLFALETMRDRYWHNMAGRIQRAFRNYMRYKHECARRIQRFWKNNKEGIVYSQVRDYGHQTLGGRKERRRYSLLSYRRFMGDYLDINGKSAFGEEIASAAGIGNEQVTFSGKIQLLVSKLGRSSKPSPRWIIVTQKAVHIVITTAREGQTLHSLERKVPLVTIKSINMSNLRDDWMCFNVNASEEGDPVFSCYFKTELVTHLMQLTQGSISVQIGPTVEYAKKKDKKAQIKFVRDETVKKDDVYKSHTVHVPSGEPPNSTSRPPAKRKAGVVRPITEGKLLRAGGPSKPRPAATPKPKPASQPLPGKSSVTPAPAAPSIVSKPTPAAATNGTRPPPAPPRAAAPPPPPPPPAVPAVPMYKAKYDFQGEEGEMSLKKDDLFEVVEKDTDGNGWWLVKKDGAEGWAPNNYLELVPPTAAPAAPPPPPRAPKSVPSAPTPAAAASKAKPIVPSAVTANANAKPVSVFPGMAPGNGSAAPWKKVTSATPEDSLGSSRPSSALGGKPVPPPTAAKPKPPAPGAKPAVAPKIPGGKPAVPSAPRPPAGGGASKPAGSAARPPPALGGQMDLAAALAKRAQRLNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPP8</accession>
    <name>A0A8H5GPP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPP8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54290" checksum="03333404C5E744F9" modified="2022-01-19" version="1">MLDIRKGAELGGERNAGWSADCYIAGSCAQTYFILDQLSTDSLELKLLHSIRIPEPAFRPSAMFGLFGTRLWGSEHRTRASSANAKQIANRRTVDCMDAGLRGSAGAQEIINMITSRPLVTKLILGHNQLGNEGCAVLFNFLRSVAGRRYRITELSLNSNGIGDRGLMAIALYLTDNTNLTELYLQNNQFTCNPSTILSFTRALNTSRLRLLSLTTNRSLSDTFAEVFFSELDSPYLGELHLSAVGITRRSAPCIAKFVSSPRCRLHTFKCNGNALGFRGVRNIIRAVEISNFTLLRVELHSNELAVDPNGAGSDNTEDEESEDDERSIGPEAWKSCEVLIKGILARNAHLKKEVEKEALEVLVYSRVILLRGSNEDVNDSVSAGSHFTALPTELRLQILSFLAPTLSAAQRLRIFIYGSSSSTLPSLLPSLRSTCTPDPSVVDVGPANVWSINNGCSSGQCMGASSFFCQREQARVQWLETVACTAYDPGLTEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSF3</accession>
    <name>A0A8H5GSF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSF3"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="6">
        <location>
            <begin position="331"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="761"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="897"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5370154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="952" mass="103682" checksum="E63E80152B62FD25" modified="2022-01-19" version="1">MSVTHCKRTSPSRNTSVPLSTTTTISKPASPTDTSPSPPNSTITQRIPTATLPNIPSVVQHTQAGMRRRQSTGKGFDGAAGSGNGGQGIRDEVPSSQSVPTDTANVARKPESAGGLDEGKDATIAPSRQSTRRADVATSDKGSQRSLKHSHTEVDVDGTSTIRRNSMESQSSSVANKSSEERVSHRVPDRRQSQESDEGTTNASHRDDGKNPDRINVPTLNNATNGIGQCLSTSSVHESTNGEYKSGTDDPYQNTPAPENTKSPKSSGYGGTGNQQQPARQPTVLDQLAMKSETQPSHPSSSYSEYRNYDYTKKYPMDELGKEVSENARVWKVYLDEAEETDREMLSGFRDTLDALLVFAALFSAVVTSFVISAVESLQPDYNQITAMLLVEQNLLLRAAGNPTAIGNVKTVSVNLDSADASTADLWINGLFFSSLSLSLATALLSVLVKQWLQAYSSSLPTGNARERAKICQFRYAGLTDWKVPQIIGTLPIVLHASLGLFMAGFSLYVSELQPSLCWIVVSVTAISFLMYLGSIVIPVVITIQCPYRIPLLFVPLNFIIFFPLQIGKYLWIRYCWGQWWLEWPSLPSNSIQAAEATFLKPDDIDEEWQKWDISLPHDPYTRHHSILADCIKWLQSLQSNDSMQDIVGQALHGIMKEHIIRGDDGKLQYFRPALKCYIDKLDLKLILSWILSTPRIDNEEYKSKLCTSLCTEWKEAQKEFNGFPQMDLDNILHSAACNGNLQCVKVMISVGADVNAKGWSGGFALQAAAANGHLEIVRYLVEKGADVNAKGGRYGFALQAAAAEGHLEIVRYLVEKGADVNAKGGENGFALQAAAGGHLEIVRYLVEKGADVNAKGGYYGFALEAAAAKGHLEIVRYLVEKGADVNATKEGYFGFALQAAAAWGHLEIVRYLVEKGADVNARGGRWGSALDAAYNRSGSQIAEYLVSKGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT96</accession>
    <name>A0A8H5GT96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT96"/>
    <dbReference type="OrthoDB" id="3261928at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="51482" checksum="F6797F0A48BDA648" modified="2022-01-19" version="1">MEPALFAPHRQPQHGISVSQAMPPQSSVAQAVTHTAPLNMSYYRDHTSYPDLPPPAYDTCDNTLPAPTPSFSARNAQPKLIPKTDALTASTPIIASAQIAFVEWFLALHDLDKDYTAGPLNGPPFYIWWTDLKDVSKSSRLKVGTNDSFDKAVAELCQSNLHKANFRVQVEFEEGDISGWCPAENEEAQELVHGTAVPSVNMYSDKSQLCGYWIGCIKNDWECRDSKHGNEHGAPGYCWIDSTGSHVGLNNKVMGEWADQIIKGLAVIMEPLNIPGIETARNRKPAIRPRGGNGPRPGKPTSAPQAPTSAPQAPTSAPQAPTPAPQAPTTTTDATALLLASVSSNHMGCSCSCSCSRSCSRGCGRRHSHCRHHKRTHTCSPSPTSSPVSSPSKVNPELEFLLSKCLETFFLKHRIDLREAQAALQEVHFTPDIIPKVSITRLCEVTKCPEGKAIQFQSFCQGWVDSKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTJ0</accession>
    <name>A0A8H5GTJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTJ0"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="538" mass="59077" checksum="6A4D11650F6D0016" modified="2022-01-19" version="1">MIEPGDVTVTGLLPALTSSAWIHRPTGRHAHQPTKSVRGVYGTPLNGIWSNVGLQVRDLVRGLKTRYSIDPARFVTHGEDGKETLGPVVIWVGAYPGSTSADTAHEVSQDILKLLEKNGVKDVEVEWHEAVSWKAACPALLRVVGNNNPIVHRGRMPRVASGSSSTKIATSTATTAPRFLREKIEGTYEFKGAGAPRQYVRLNGLRRFQRGLDEIKVAVSDHRMLADLYAREIIRLEAKGTSEDEEEAEEDAKELLKTRQNLDEQKQAIAGLEKFYEDVKAQWSDIELRNIGHVHYSPPIYADVEGTAIAPEKLTVMMYPQSDGRKTFKYPENRQLKINGIVMRELLANPDLFDSEGQPYLIVLKDGCTTDLTIGRYAGLESFLCDEDGVESIELAIYNYVKMVGPFSAKRDSGSLIFDGLGRMVGLLHSGKSKGGSTSAHVTRGIRTPTSIAPPGGKGENNIVGILLSHFHTPPSAARFLALGYLLVGFFGADRCFDRWAAIKMNASGLWIDLIGGDEPIATAVEKVLKEKVTARDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW35</accession>
    <name>A0A8H5GW35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW35"/>
    <dbReference type="OrthoDB" id="3038990at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034219254" evidence="3">
        <location>
            <begin position="18"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="520" mass="56460" checksum="7601B0F80B48A9C9" modified="2022-01-19" version="1">MNTFASSFSLSSPLSLAFFLSLSFPRVPHPHSPNTLPCTSSTTMSADAGALPTGSSSMESSLSSFGFPEAQFHQLQITLCVATATLGMYIWDICSHLGEDYQLLKRSKSRPFPTVVYFVARLSSLGFILSHTLSLTARIKNCYALSKSTQFLVVISLSSVTLLFFLRLRAIYSSPSSSSHHHPSSSIFSPITNNSNSIIIILFFLLWLANVACASLTVLLISHTLSVDFGGTLWCLEDGIKIKYASVTAIGALVHDTCVFVAISWRLFRFGESGVTMRVDMPTMSGPGGDQNQNSVLGQSKDDGEHDANHGGSGVNLPVNTVNGLKKTTERYVLGKSLPKFSRALFMDGQMLYLITLIASLSTTLLLYIPSIPTAYRLIADVPQVAILSALACAVFRDARLGRILERSSYGYQAGPLGHAHGMDTRAYYNVHDAFGTGASWSFHQGYRHGRGHNHDSGVNNMTLSTEMYTYASRGVELSTTNESMLDCDVEDGSECVHGHVHRHGLGYCAQDSEMVGIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXU6</accession>
    <name>A0A8H5GXU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXU6"/>
    <dbReference type="OrthoDB" id="10636934at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="278" mass="28231" checksum="C9B14A5CAC812C7D" modified="2022-01-19" version="1">MYRLTSGLKTTHVVTVTTVGILSFLLFAPQALALPPPMFGQLQGRDISIAGGGSVCKDGEIGIGKQNQAGVGMVGVIVANDCNPICSKKPKDGPLTPDSLSPYCGTDTEYDQGCSVTCPNNRTETGGFTLPTSVITTDKRQWGNCYEAEMSQVCRYTGAVATIQYCCSIPNGGSLPTNSSTPGGTGGDGDDPNDGTTNTTSTADGDSDSDSGTATSTATDSADDSLPTDSSTDSSTDTNDPSIDSDSSTTGSDESTDSATTGSDATGSDDSVDSNPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZI5</accession>
    <name>A0A8H5GZI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZI5"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5373695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="811" mass="88927" checksum="B62A7464E760D22D" modified="2022-01-19" version="1">MTARRILWGKAANAGQTCVAPDYIIVPKEFQDTFVKALKEVYDEFYPDGPGAPGAMSRLVTPQAFNRVNTLLKNTNGTVVIGGETDEASKFIAPTVVKDVKPDDSLMSEEIFGPVLPIMPVNNFDEGIAYVNAHDHPLSLYVFTQDDKLKTKVFESTQSGSAHVNETIIHPGAEGLPFGGIGPSGSGYHTGKYGFDMFTHLRSSISPPGWIDMIMSFRFPPYTTLFHSFGGEHSQNVRPETVQNLTEKLSELLGEDVVRDAFANGGMGAERFNEEGLPVVEITEPAPTSAPTTTNTSLLNEPELVLLDSLSPAERERRRQERDRILDLLEEEETLEQRREEERERLEQIEAAQKRKEAAKLEMERLKMARETQKKMGKALLRSVSGNKEETSDGTKEKEKEDGKSTKKSVSFAAESQQQESAEKIDWGDIAFGKLRATKQLPTLLSQNFQDGKLMKSTVVERIPGVGRVNAAPTKSESADSDDESDIDDGEDSGGDELEEEEFDAYFAQQQREIALEYHRKRRKFDEAAAAALTSHSHSPEEDVLVGDSSSKSKPAQLSSSYATSQSLDASVLPASAAQTLQRSIRMGKLDSDNNLVGRDAGESDSEPENENVREVMELLRKGEVYNVGPNSDIHSVPRSTTSELSATKPSLQAPPFTAPTPLPSKPKNSQFKLSRPQNKTSSMEAGSEPATPISVVGRSSPKLPTVGSLVEASGSKNPLPPGPVPSPPSMVSQSPLQIPDFSRPMIIESPSFPQDSRSSRRPERPPEIMSASVRESAPRNREVAEVESVDGDDEANRPPKKVSRFKAERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZZ8</accession>
    <name>A0A8H5GZZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZZ8"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="2">
        <location>
            <begin position="338"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56312" checksum="5774D4C5341E7924" modified="2022-01-19" version="1">MSNDSILTQILSQIQALQVSQQTLAAKVDALAGGGPTTTTSSTGATAIPQTTSSDSIDVPIATSLSTSPPPGTALMMETTDKEREKALYPGRVLLTTYPDQHGIQPYVLHWFAKDPLVRGPVICSRLPSSIKLRNALGAHSGSYSIYRALAIGMGTLSPSHRPDYSMTAPPVDIPPNESWWTPGRIVSFDPWGHLAAQIFANQLLTKEAGGENLDIRPSIAVTRAHIKLSELDETVRRGEIDVDGKIVMKSRPVKREDGSVNESIDPGVEVAVSKAAVEPVWYLPGVAERFGISETLLRRSLFEETGGMYPELITRPDIKTFLPPIGNFTVYIFGDPALLSSSSPDVHVTLRVHDECNGSDVFGSDICTCKPYLVYAIEECIRTAQGVQADMVKDGKKKGVGVVVYFRKEGRALGEVTKYLVYNLRKRGGDSADRYFASTEIIAGVKDMRFQALMPDVLHWLGIGVNERGNVGADGKKRGRVDNMVSMSDMKYDAVVGSGIDVGRSVPSITIIPTSPFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1B2</accession>
    <name>A0A8H5H1B2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1B2"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="47"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="423" mass="46111" checksum="78F2C02B163E12FA" modified="2022-01-19" version="1">MLSTVAIARRSAPVTLRALSTWSAVPAGPPDPILGVTEAFKADKDPRKINLGVGAYRDENGKPYVLNSVQKAENLVAASRPDKEYLPITGLAEFNKNAAKLAYGADSTPLQQGAIAVTQSISGTGALRIGGAFLGRHYPKAKVIYLPTPSWGNHTPIFRDSGLEVRGYRYFDKKTVGLDIEGMKADLKAAPEHSVVLLHACAHNPTGIDPTHEQWKEISDIVQEKKLFPFFDMAYQGFATGNISNDAFAVRHFVSQGHQIALAQSFAKNMGLYGERVGAFSLTTADPEEKARVDSQLKIVIRPMYSNPPLHGARIANAILSNSQLYTEWETEVKSMAERIISMREKLYNMLTHDLKTPGEWGHIKSQIGMFSFTGLTAPQTKALAEKAHVYMTADGRISMAGLNSNNIEHFATSVDAAVKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1N3</accession>
    <name>A0A8H5H1N3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_000213</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1N3"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5374775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="116" mass="12946" checksum="EBB2AE4F5432A02D" modified="2022-01-19" version="1">MSALSPLRAVRARAGLPIRNGTIQSKRLASGSPHFNEPSGLLFGEKPLPPGQKRVKEGWENIWYFGMFGSMGFAAVMLYYKPDTSIQTWALLEAKERMEARGEKYQYEPSTTSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1X3</accession>
    <name>A0A8H5H1X3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1X3"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="802"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5375289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="990" mass="110857" checksum="E94B4B2F4CADB142" modified="2022-01-19" version="1">MYFPTSTARQLSTIPALPNLPPEPVLDLCPSPKKSLFCTLTRNGLSVWRVRPSALLAFLSRTPTSIIDHGENRKAHWSPDGNRVTSESYLVLVSVIYSPDEPVYQIPPLPVSARRNFLAGPGEGFPLNAIHLHFEGVVRIEGTLLSLSPRKDCIYLSTRNPPSIQRIPWPSQGEDEAEEYDAGEHGRRRRQFTSYDNWVINEYDFHWLIEHEVSVSKILFSRATGVETWITSDGRAYFVHLTEVPVDVQDYEEGFSPEDDTRARTPRPGRRSSSSDAGFPQDDDVSYTEVWQGMCVHDFDTPKWVQKQRRIDPDEPLHQRDRKVYVEPKRAVLIAVNAKFSLIAVGMLGGGIQFTNFPSQEGVLPASQTIEIPNAINKATGAVCAMEWSSDGYVLAVGWEHGWGIFSVGGRCLVSAFGADDVDDKKFQDVFMNGVSSLFWAPGNFELIILSRRSLETTDGQLFVIPFAKSATTGQHSPDNTRYAFLQLDDRALVYRGADQPDMSVINPESDVWQHIEIPQTYLAANWPIRYSSLSSDGRLIAVAGRRGLIHFSASSGRWKVFSDEIQEQAFAVKGGLIWFHHVLIAAVEVSRTYQIRLYSRDLELSNQNVLHREIMSAPVVILSLVDNTLLVYSADNTLSHFLIVPTPDTIKLHLCAQKQLGDPVNDLAVATVLMVVGGQLVLLRPRKSADQEVRYDMQIFADRVEFCWIHLRGITSLENSLWAFDGKGIRVWLNALAIEAPNSAVDGASVKESVNIPLEFYPLSVLMDKGIIIGAEHEAATRPNLSFVMFRHATSSHLFLHHILKYHLEASQVKEAVAFASHYQNLVYFAHALEILLHTVVESDATTDNESDTDDSVVLSNAVEFLDHFDAALDVVVGCARKTEVTRWRRLFDIVGNPKNLFETCLVSGRLKTAGSYLLVLHNLEQLDEKNGDATRLLQSALEAKDWQLCRELVRFLHSIDDTGAALRHALVQTDVMDIDMDDTTNVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LFX4</accession>
    <name>A0A8H5LFX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LFX4"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="22964" checksum="21B6E1A3C7624ED3" modified="2022-01-19" version="1">MAGEVKRISKLARGQTSSLRKEDFDGRPGKTCPHKGATLTVSNVGAIRHTGARPVLVPGGGVAIVAVGRARWEWDADPAYDDYHDRDTLDAASLGFDANPESGLLGTIQNGLGWRRVLLPISFSADHRVLTPPQEIHYQTQQRPQHSQIANNQTWPKSHLLSGMPTPALHNLSSQLETHYASCSGASNSYGQGGEESGDAGDEVRFSGIDSNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIX8</accession>
    <name>A0A8H5LIX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIX8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034588076" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="38"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="244"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="510" mass="55169" checksum="73D37C86DCAE6CAD" modified="2022-01-19" version="1">MKLTVAFLLVSATVTTLASGVTSNTESDAPIVDLGYASYQGSFDASTNVTNFLGVRYAAAPLGDLRFRAPQSPANVPGVQQANTEPPECFQASSGLSPTNPFSNQTLAKRQGREQTEDCLFLNVAIPGSTIPTGELPVIVWIHGGGYLGGDASDFHGSDLINEAKGGVVVVTIQYRLGVFGFLAGKQVKQNGALNAGLLDQHFALQWVNTHISKFGGLNSKVTIWEKVQEPVQFFSKLLRKMDELALYSEVVAQTNCASSSNPLNCLRSVDANTLEALNTNINSAGFFGLFTFVPVVDGEFITQRATEALKQGKVNGQALLAVTNTNEGVNFVNQTANQNTTFYAEQLFPNFGIQQDRETARQYAGLGSQLNQINLIQGESIFICPTYYLLNAFSGRSFKGEFAVPPATHGMDIQYYFPTGSTSSPFQNADFQKAFSQSFLAFAISLDPNSKFDPTNITPRWNKYSAGNTEMVFNSTNDGSAADIHTISTNRALLERCSFWESVGQLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJS7</accession>
    <name>A0A8H5LJS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJS7"/>
    <dbReference type="OrthoDB" id="2741288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5359931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="57097" checksum="8DD756F929225B6A" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILLSWLQATGLSSVLGSDRPSDATMSTVSPLSAEDTAAQAEAITAALKKQANWDEKNDKAIGSIKLRLSPAIRQKTLGMTSAKEIWTTLKTAYGKPGVSAVYTDFKRATSITIPNDANPSATIELIRMHFDRVSAAGISTDTTDSTTPNVSIMKIPNFLIVMFIISKLPPRYEYIINQYTQLSISQIDNQDLDELQSEIVNVWKSCQGAFKGKPQANRLSAIKRKDSNPSFQQQQQQRPSGSSSGANGDNKGKGKGKGKGKAHFRQGGRAGKNEQAKRQGQAHLVHGDMSPMMHTVTFVDTPTAVDSRKPFFMEMEKPFDAFFTGTKRAINLARDIGARPSGETVAALEDVVISHPDLSSFTPLTPAPRPKRTLTERIYWNNLQSSSDDWGCNDNWNDAFTHSVGTQTDSDADMRCAQEEDASWNEDTLVNTSELGSVFGSTTTESGVKVPQDTRTPVPLIDRLASDPAAEIMECGIHLGERFQNPEDPLHIYGEGATPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJZ9</accession>
    <name>A0A8H5LJZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJZ9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5359934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="218" mass="24365" checksum="63128EFC4B0437EF" modified="2022-01-19" version="1">MAALVPPTISLALFHPRCMACQTCQSQSVEGFAPAGAFGTQCECTFVNTQTPASTASNSTSVHTVKKEDLEALQSVTTSLDKPASSSQQEVLGATVIKPVWWSKDGPEGSVTEPEDQDIPDSDSKFDFLGAPLADRNASWYERRLDVAVALDNEHACAQHREIVEDQRLAEMQVELERMRLRISVQRVLVKKQQLQREKLARVVREMRRRLTESRFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPX0</accession>
    <name>A0A8H5LPX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPX0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034310351" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="576" mass="62773" checksum="808C54F4257F46FE" modified="2022-01-19" version="1">MTPALLLLFAFSTWTSVFGAGPTVSIGDFTFVGRQTSENVEFFGGVPFAEPPIDNLRLKQPVLKTFSSGKHTVFNATRFGPSCVQTLVPVDEVSEDCLSLSIFRPANLEREQAKGDGLAVMVWFYGGGFIVGSSSMYDGTPLVNRSIFRGTPTIFVAANYRLGPLGFPRGDEVAREAASGSRILNLGLQDNIVALQWIQKHVASFGGNPSKVTVFGESAGARAIEVLLLSNQIQGLARGAIMESTGGSPHISPTSSAANTVWDNFMAVLPQCANTSMTDVECIRHLKTSELIEGFINSRIFFNSSDRIWGPTLDDDIIPSFPSTLKPDYGVLEAVMIGCDKDEATLFTDQTVNSTQAISDMILGSPPSPPDASPSQREVQLQKLQHILEETLALYPNIPSLGSPFDTGNETFGLDPEYKRSAAVSTDKKFQAERRFHINHQLLPAGISAFSYLFTDPDAVPVQDFVTGSPVPGSLGVTHSSEIFYVFGTLAERPEVKEVTTTAAKLSDMMMDYWISFANTLNPNDGKGSTRPNWPEYTANRQELMQLNGHNTTAIKDDFRERQIAFFNRDPAVFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQN8</accession>
    <name>A0A8H5LQN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQN8"/>
    <dbReference type="OrthoDB" id="2770090at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="21537" checksum="9432C1065D1D732A" modified="2022-01-19" version="1">MSSSSLPASFTSLYRLFLRSTSASVLHHKLARRNLRNLWKPAFVEAAKAVKELQNPSTSSSTRGKLEAWLDVWQRRMDNVLALLYSSSTSRGLPHQLTRNLSLIVYSEHSYASRLKTPYWRPQLAPNAPEYQILPPSAKQLKKEEKERGYKYMQDMACNTLGQVARMAEGRDEICLGRVRMKGKTFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRP6</accession>
    <name>A0A8H5LRP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein MOCS2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRP6"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15675" checksum="5B50398DAC695C5D" modified="2022-01-19" version="1">MDLTDLIASTVQVQIRDASSFPSTTMSSASKSTSPPTITVLYFAAASTSIGLTSEEITLPVVKKHSTASEQNESESESTSGPFFLSSLPSLIISLHPDAPNLKQILEESQWSVDVEMVDKEAKDGGSWDKVELRGGEEVAVICPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSG5</accession>
    <name>A0A8H5LSG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSG5"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="607" mass="67980" checksum="715DC9FC93EDF1C4" modified="2022-01-19" version="1">MSTTEWSPSTWRSKPVAQDVEYTNQDQLDKVLHKLGTLPPLVTPSEIERLRYQLGLVQHNEAFLLHAGDCAESFDACTHENISTKIGLILSFSLILVWGGRLPIVRIGRIAGQYAKPRSSKTEKVRDKEVLSFRGDNINGLDPDDRTPDPERLLRAYFHSTTTLNYIRGLLTSGFASLHHPRDWSLNHVRSPSLRREFENIVDSLSDALDFSRTIGADTSGLSYERGGGRGTLAEVDFYTSHEGLSLPYEEALTRKISIPSGIKSREHTKTFESQESKDSDTTTYYNTSAHFLWIGDRTRQLTGAHVEYFRGIRNPIGIKVGPSMSEEDREPKQRLGQNHPDHSLRRLKGKVLRGRLDFHFISFSIPFSSLFLSSTLHIARVSGYSPVFAYIPKYVSLPPSCYLCSLYHCIPTYASRTSLAIDGGAHRAFDVPQPHALIEEYLASHITAVRKSGHPVIWVCDPMHGNTLTSSGGLKTRNFGTIISELTACLRIHAENGSRLGGVSLEFTGELNDEGFSVTECLGGSMELSEEQLGLRYQVSMDMNKLVESGSENVEDRMDGGCLREADDHDEQMVRIIDIHQDVMRLPRRLFENQGGQPDGRCLRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTF0</accession>
    <name>A0A8H5LTF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTF0"/>
    <dbReference type="OrthoDB" id="3051850at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="316"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="720" mass="80397" checksum="E8D3C7634B03B4B6" modified="2022-01-19" version="1">MDLKLLEHELCMLGVPKETMDWLGRRFAGRKTMLAFDDYESEPFNVHGREDQGDPFSSVGYIAYAAGALKIIQEEDNTEGFGFMDDLAAVLRNTTIASENYAKFLGVLVDYGIRWKEQFARMVKKGQGWVHQFRRMANVTKGVAAPHVHNLYKMKAVERMLYAADVVLTPQRQSRNQSDPISSMGVVKKLTSVQRQAAIIITGALRTTPTELLNLHAGITPMLLEIHRHRHRAAVRICTLPLTHPLAGLLHQARVQSHEARLTHRAPLHDLLRTYDLQPDRMEKKSAVRYPASWDPEVDVRLWETEEEATEHFLSDYSHIQVYMDGSGYQKGVGTSAVLFRNGKEMEAIRYRLGTDMEHEVYKGECIGLLLALCLLAAEPDVQSVSLWVDNTAALQAITNPKPGPAHYILDWFHHALETYKRQNPDLPIFLSWIPSHTGILGNERADEEAKKAAAGDSSPIEDLPAVLHKPLPLSQTSVIWTFRNKLQSCHDDAWTKSPRYQKFKAIDPAGVTKAARNYQKLIQGLHRKHTSMLRTTENSKIAKERPRDSKGRFIATTTTPTVSATAPTEPLASSATNPTLSGTLTTISSLTESSITDSNQSGPEPESFTPPTSPPQIRDTETWVDCIARERKEHGLLNPSVPPSHIPSRVNSPALTPLSPKPKPKVNFHTMAAPEFAGGSKEKTNPLDFLRKAEMYMRQINIVPNEMGGSVNLLFKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTU1</accession>
    <name>A0A8H5LTU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3047174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="809"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="1457"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1901" mass="216927" checksum="22FD08694E215F4B" modified="2022-01-19" version="1">MTSTDRQCPLPRNHVRPLAGEKTGSSESVGWRLGKVIPTAKNSTPSQSRFQAGTTSSGLPAPGGVDDSSASCGSDDGAGSNTAVTVSRREPMRDATNQQRESALTNSSTSHVTSLSQEYLPQHSNTRSINIRMLDTNTNETVHPNALRINETQNSSPTVSTANTREKSQIVDLDQQTPTPPRSLEDQLMESLGMRMDEESYEQSQNRLNQLIDQIEEAMRSRLRTQVPHSHSTTHEPNTNPSRQERRTALRTGRRNKDTKASIKVASLNIRGYGPNENLEDNKNKWNYINQFVRQKRIGVLLVQETHMDESRRQKIQDKFSKRLVLRCSSNPDSPRAKGGVAIVLNKDLVDTSVLDETEVVPGRALLIRMHWHRDRNLKILVVYAPNVSGSDGKDNKEFWETLREYFDRNPSKRPDILAGDMNMVEAGVIDRLPARDDPEDAVEALDELKMSTQLRDGWRDTYPDTKAYTFHQTATGSQSRIDRIYATDAILTASREWKIEPTGVPGADHWMVSVLASHTDAPTIGRGRWAIPRHIIKDKTFMQYALKRGLETDSEMNKIHTLGRTADRNAQLTWYRYKKDILEVARQRQRIVMPRLEKQLEELKGKLEQINNDQSLTEEERVELSATLTNDITVLERKQFQNTRTDTATRNRIEGEQISRYWSNLNKERKPRDVIYALRREEPGPDGWFETSPEGMAKRARDYHEGLQKEGQATDAEHQRMKQAMTDRVLSNLNTRLTEEQKTYLAMKCDRSDVVIALLSTKNYTSPGIDGATHELWKALYSRYVEDTRAGRPAFDIANLMTQAFNDIAMNGVITDTHFADGWMCPLYKKNDKCEIANYRPITLLNTDYKIFTKVLATKLGKVAPDLLHHNQAGFVPGRQISDQTKLIRMVMASAEQNGQNGLIISLDQEKAYDKVDHDYLWKTLEKFEFPKEFIETVQRLYKTAKTSVMINGIQSETYEVIRGVRQGDPLSCLIFDLAIEPLAAMLRNSHLQGFRIPGITERLIANLFADDTTVFLAASDDFKDLQDILDQWCMASTAKFNVNKTSIIPIGTEEYRQRVISTRRTIVYQYGTNPYLNVLPPNLHIAREGEAVRILGAWYGNKIDATQIWAPTIEKIDRVLERWAKGSPTMEGRRLITQMFAGGMSQYLTQVQGMPPEVEKRLAKRVSKYIWDEKEKNPVNKDATYLRINEGGRAVLDIPARNEAIELMWLKRYLSFGPDRPLWAVIADSLLATNTPRAEDNIPQRIKQNCFLQSWSTSSSPRSAQVPELRRMINVGQKYGIRIEGLAFARDILREMPIWHHIQADPRIKRLTNSQASKCLMEKHRLTTVGQAEDLAAPLVTTTERRSLHRRNDRCVCRDCQEVRQRHNCTHPHQCMLRAEELLNTLPQKWDPRREQPEDYEIGPDDHEGPQERNAETFDYRISTTGNLSDIFRIFTDETVPPSDEVLIRKVNAAEGPDTIIATDGSCMNNGQEDATAGAGVFYGRNDARNKSIRLPRRIENRNIIQSNQTAELVAAMEAPEAITKNTQMSLETDSKYVISHLTTSLKKMEDIGYINVNNADIIRTMIARYRLHEAPIHIKWVKGHNGHEGNEAADALAGIAATRAQEDHLDLNIPQTLRITGAKLNALTQKLAYTAIRQRKATKTPDRPRTRAILTQVKLQVQSLFNVIPTDPVIWKSIRSRDLERKTRYFLWMVMNDAYMTGTHWQRANYPDEIKERAICQHDQKTEDITHILVGCESPGQGLIWDMTGRLWERKNRTLQWERPALGTIVGAGLAVFKTPGGARKSGEERLWRILIAESAYLIWRLRCERVIRKDNAPFTTREIENRWSNMINERLQLDRRMTSRKYGKKGISPNLVRATWQGLLDREHTLPDDWVTNSGVLVGIESDLRRQTGPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV03</accession>
    <name>A0A8H5LV03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV03"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="414" mass="46535" checksum="AD53575AA3D08A38" modified="2022-01-19" version="1">MPSKQNEHLSRSWTDSISKGFEEIARELEELYRYLSQTGHSSWSYDPEKEDTYMKAFRIYASITIRRALQDLHRNNPSLFQTNGSSLILSGHTITIVEGNAYNWIYLADESEDSAGICSPWDKTRYLLPRAPAAVSRAKAHVAFLLNDLSSTNFEISDCQISLIAGNLYNSWILWPPYSRFHRDGILWNISGSNYSAIYTKERLVKEVNNFWQTAFPENRSQPMSWNSENSLNFNLTLSNFNATLYHGHCFWTRRSFPVRRRLAWTRTDTPNNDYTGSNQPLSDDDHDRLDATTENANHRHSPTPPARDPFGILTLVREANATAVEATYATIGMVRNPAHSISTDMFRGANGVTITSCTFNVVAEKQENNNGDRKGLSVLAVGTGGVIVAIVVVLLIQVLAVGNTSSLTPTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV30</accession>
    <name>A0A8H5LV30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV30"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5371105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="518" mass="55397" checksum="FCC156282B4194F3" modified="2022-01-19" version="1">MPFRPVYSLLLKPPLRSLSPSVSFYRMASSQAAARFGLKDSSLIKTQGLIDGKWLDAKDGSTILVTNPATNEELGTIPEMGLAETKEAIDAAAKAFPSWSKTTAKARHDILMKFYALMNEHHEDLSRIITLENGKTLAEGKGENTYSASFMEWFAEEALRTYGEQIPSPLPGVRNVVIKQPVGVVAILTPWNFPSAMITRKLGAALAAGCTTVIKPPPETPFSALALAELARRAGVPDGVINMVTTEKNVRDVGKEMCESKIVKKVSFTGSTPVAKLLAGMAATTLKKVSFEAGGNAPFIVFDDADLDEAIAGAVICKFRSSGQTCVCANRIYVHSGIYAEFASRLAEKVASFKVGNGLEESTTHGPLIHGRAVEKVSRHIDDAVSKGAQILVGGKAVPNSNFFNPTILSDVPADALLNQEETFGPLAALVKFETEDEVIKLANATDVGLAGYFFSRDVGRAWRVAEKLEVGMVGINTGLLSQSVIPFGGIKESGLGREGGHGIAEYMNEKLMVFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWL4</accession>
    <name>A0A8H5LWL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWL4"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31420" checksum="805036A1B6EFC11F" modified="2022-01-19" version="1">MPQVAPENPYGYVPDDAICIMFIVLFAISSTTHLGQAFWKRTWFMIPTVVLSGCLEILGWSARLWSSKNILLSEPFSIQISTLIIGPTPLLAADFIIFGRLVGILGTQYSRLSPRLYARIFLTCDIISLVLQGIGGGWASSASNNGGDIDPGTNLMIAGIVFQLIVIVVFATLAAEFAYRFFNDSPFAKHSASANNRGDLSGKRKLALGGIAFTIVVLAIRAIYRVIELSQGWRSKLMHTQWLFGLFDSAMVILAFYCWNAFHPGWTVVPDTQYFNKEFSRSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWU7</accession>
    <name>A0A8H5LWU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWU7"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="224"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5372980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="444" mass="49511" checksum="7A11442AA9C2E43B" modified="2022-01-19" version="1">MEAGTVPDCLAAQCIANMDKIGMTELELAYSVSTPFGAGIETTAGTLTVFVLAMLHYPQVVKKAQIELDTVVGHERLPEFQDRQNLSYINAIVNETLRWRPVAILGGTPHAVVADDVYKEMYIPRGSTVFANFDRIMHDPEMFPDPEDFRPERFIDSSDPRIQDFDLPFGFGRRQCPGQHLALNSLFINISRLLWGFDITPALDEQGNPVLPVLPPDSNMDAIPSRTSVSLGVFEVAVKSPGRYMQALTILQQHISRLAVTIRRFWESAQRTTRRSGGIDAVVIFAILRSKTNAFPVSTVIIEQYRPPIDKFIIGLIDEGETAEQAAIRELREETGYKADEVVESSPVVVADPGMTNANMKLVILNVFFEGALETPDQQLDSGEFIVRKVVELKKLHETLQEYDRKVYKLTLSRTSMLTTMQGFAIDAKLHHLATGYALALQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXM3</accession>
    <name>A0A8H5LXM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXM3"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36842" checksum="BB5E4BEE76576D5E" modified="2022-01-19" version="1">MSPYRNHVYGWAPEVDTEDTSSDSCHVLLTHSRYTHSSSSCSPISSPEPGSSPYSPDEANESRTARKGDPEWVPRPRNAFIIYRCEYTREHSRGGPRGRNQPHTDKTLSKRAAEAWHDLPAEQKKKFKMLAEQEKLEHAKAYPNYRFKPARKTGGSAGRRRKVRSSAPVPVRRDRHTGSVEPSEHESLDSLSPPLERLTLDSSYRPYVMPPIQGSDAALSLTDSGLRRSESSTETWTQSSTCSEGSTLVCDGTYEYVSSPSADIPSSVKTDCHTNYIHTPTPSYYQSPTSVISSSLANWNGDPSLPSTPSSSTAHWSTGAFQYPINNRTTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ARV2</accession>
    <name>A0A8H5ARV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_019123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000612">
        <property type="protein sequence ID" value="KAF5309739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ARV2"/>
    <dbReference type="OrthoDB" id="3069970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5309739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="18727" checksum="EFA3BA3B7A3EAA4F" modified="2022-01-19" version="1">MALQKAAVKQHMIWLERQEEKTSWSKPRREEGQLGRGSQGTRSGRARSMEVNAFQDSVPGASPTTKYPPKLTPQERDKMRKEGRCFRCRGQGHMGNDCPMFPSMPPTTPNNTTWRPSIKKTAVVTETSEPKVNTTTDNISELTARIGALSGEEKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTA2</accession>
    <name>A0A8H5BTA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000380">
        <property type="protein sequence ID" value="KAF5327952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTA2"/>
    <dbReference type="OrthoDB" id="2823624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="112" mass="12457" checksum="FB6F77F87BC22115" modified="2022-01-19" version="1" fragment="single">MSSRPYNLNQYGPVNPGGSKQKTARSVSSSYEPVPTNVERYARSRTTAEPITQKSSLIPNPNDWRYNVSPHVAEADDAIHNIDPENDTKTSRTRIFSGRGYANYGCLLIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYF6</accession>
    <name>A0A8H5BYF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000318">
        <property type="protein sequence ID" value="KAF5331785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYF6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="628" mass="69806" checksum="369D7FCE783ECA8C" modified="2022-01-19" version="1">MYFLLLASVQDALHTTIALRIRGAIAFKAPLWTLYTQRLLSESKEQSLSRLLSESIARVPTTSFKQEWASFVVSASKTLHTRTTKDLVTNTLRIWGAFLFESSKTLHTPASKNRSTIALRIRGATPPSSRQRPRRCTPPRVKIGQQLLSESEEQRLLRLASVQDAAHPRESNASFVSPASKTLHNPASKNRSTIALRIRGATPPSSRQRPRRCTPPRVKIASKTLYTHTTKNRSTIAPRIRGATPAEGSLRVQRVPATSFKQEWASFVVSASKTLHTRTTKDPVTNTLRIQCTSFVSPASKTLHTPATKNRSTVALRIRGAIAFEAAFWIQRATSAKTVPTLSVWASFVSPASKTLYTCTTKNRSTIAPRIRGAAPAKGSLCIQGESTPSINRKSTLLSHQRPRRYTHPHNQFHRKTALRIRGAAPAEGSLWTQRVPTPSFNPECTSFFSPASETLYTRTTKNRSTVALRIRGAIVFEVPLCTLQLKEYLHLQSNQVWASCVLPASKTLYTRMTENCSTIALRMRGAIALGLLSGSREYLLIQLIQNRLCCRTSVPDATTPHNQLRGKIAPRIRGAAPPKGSLCFQRESTPSINQKSTLSSHQRPRRYYTPQPISRKDCSTNSWSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZV4</accession>
    <name>A0A8H5BZV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000310">
        <property type="protein sequence ID" value="KAF5332346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZV4"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="43708" checksum="30089A2D30E0182C" modified="2022-01-19" version="1">MASDSSCNDINDCRKIFDITWGCAVTIFACTWVSVHPNVPPPDSGRIFIALRRCFLMVIAVIAPEIMIIFALQYRLSITHGFFISMGGFVTRQGHHPITLPSQLTEEILLDIKATKVQDIEDKSKGDAVSKGLALLQTSWFLVQILTRAIQHLPITELEIATVAFAILNLLMYGLWWFKPLDVQRPIMIGLGPEDISISSTISWRQLLLSFHFLDLLVGDYYPNREESVSVPIIWAGSDKPTEAEAKTVPSVVTFVACIFGAIHCFAWNFSFPTSTEQMMWRISAAFVALFPFVYFLGWATHYIWEDLDWQSLLKRFRLLRYISSFLKGIFYNDIVVLIIVSFGVLLYVVCRLILLTIIFTTLRSLPSDAYRDIDWTRYLPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZW8</accession>
    <name>A0A8H5BZW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZW8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="229" mass="24193" checksum="C18B7597A961E988" modified="2022-01-19" version="1">MGHAAWLPLTSYYASAFKNGGQYPGISKDEEKLVMWSRTHSAQAQVGDPVGEVTGKELVEDTVWTITLLTEPANVTFEVYAYTPSSNANDNSSTIISSQTFSVPAGLTKLAMPIGFPDADEGVQSLSVRAWVLRSASGSGSESQDEDTQQNQDTTDTTDTLVMQLDAGNPNASDSNTNTGNGDAQRQGDGTGNGDGDAQTLAPFVFVKNPEKYNYNAWVGCVSSSGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2H4</accession>
    <name>A0A8H5C2H4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_017178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="JAACJM010000286">
        <property type="protein sequence ID" value="KAF5333786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2H4"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="11">
        <location>
            <begin position="472"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5333786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="713" mass="79923" checksum="71B33FF32386C43E" modified="2022-01-19" version="1">MTKANFNMDTNKDDCVGIHPDNIAENYSVDGTPIHCKAHQTGAGHDLDEEDNSNAELWYGIQDDNNDSECRNSLPAMVAEDGDHTIYEAGVFIDALHELRALNHVPASYGILQDEWEDGQYLVVETIFTGQNRTKMFNIPLPDRIWQPQVELWAQGLVLMDKLLAQSLVYSPFLPSFPIMLQNLKKKKSKFGATLPTGLKKKTHSYTLHKLSGHHCHGLPKLVPTSMSNDSDQDKNDPEDQTHDNIDSFDSSNNEDEDSDNMGFVAGPVMHTLRECNGKPHQDLVNNLVQSMPMFSSSAGPSSSAVSAAQAETKQGLKGKQPAVKAAGQHRIQNHSRRSKGKQKAPSHNVFGIKTLIFVPDGVVKANATHSNKHNIISPHLMITSNKWRKTPGGVTLQTLHDRGLTFSNDSPDGFVFCKDMSKAEFINALQAYLPAHCMEDSLSDGGELVVTPWRTNFDGNTIFVHSRNCCNCFSNSMLVIGPINWAGLKPEYCECALRCNQSPINFNQSISFATEIPHINIPLTSWAKIQNIGSTVQVFIDGMTTFSGKTYHLIQYHFHTPSEHRIENEYYPLEMHMVHEADDGEHIVIGVLFQLSNFGHTTNFVHQTIVNINDIREPRTQSITGYLDFSILAKAFQITPIYQYTGSLTMPPCTEGVTFLTLVHPMALDVISYNKLKYVMKFNVRTILVKKTCYKFPHERYLNFNSRIGIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4B2</accession>
    <name>A0A8H5C4B2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000252">
        <property type="protein sequence ID" value="KAF5334728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4B2"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="21348" checksum="B9A9F629C697324E" modified="2022-01-19" version="1">MSQPEQPEHSEEETALADAQNAASLQARQAIKAEKRDEDEYRLQQALKVETTSGDVYGSNIVWCGLDTSFFFKFRVLTRWLHSGDVNLEPEYQRDVVWTKEKQTGLIDSILKKFYIPPIIFVVSTDDDGNETKTCIDGKQRLTSIYRFMDGLILHRTQSQTKNSGTKSTLQFTAARKSQLPVFYLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4L8</accession>
    <name>A0A8H5C4L8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4L8"/>
    <dbReference type="OrthoDB" id="3026831at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="789" mass="88486" checksum="9E730D8FB7D2D382" modified="2022-01-19" version="1">MARIARNFFQNSSHFTVYGGINVNMVEGNSYRYDADQGGLAGDAEGLDDEEFEIIDKPILSMQVLEDITASISSAPFLEPSLKILRCSLRVLAQLEAPESKELLTNLVTMAIRITATVDGHFSDGVCPLDRTVDGLEQCLENVKSCVEEECQWSWISRAIYSRGVAGRVAVLERMLEDVLATFQASLSSTRLAVIKKILIYHPALGSRKNIKSAPTGFISYEDVQTMKNLYRGSSFQVYSARHKNHVVVLKEFCGSRAKQHLQQVLNLSHGLMDPCFLKVKGISTPESSTQFIVFDNACSGSFELKIASALQEDQKQSIRVGFTIVGGISVEPLPNPSTNKKLLSILKTQQAGLAYLRCKGIPLDVLSAKSLEIYITDDNELKIGFAPAKTDVADPPDDAEEDRLWEIFNESCLNTFERANRLLYQEERVALTDESENQTVILDSSESDSSEQFIEESVPVAHSSKARRELSWKVVRQKTTTVELVAQHYQDYLNTSQLKPTGSFALRQLEARTRGLIPGQRHQCSGYKREQITFTTTITENAVISHSTPFLGEICYLCGEQVEQDIDQNPSTYATTANTTANTTKPPPADPFQAQAFFRDFVNNEKQKLNLKRQALIKRKTAELVKFSQSFKLNTPVPNNEKQQLNLKQQALIKRKTAELVKFSQSFKLNTPVPNNEKQQLNLKQQALIKRKTAELVKFSQSFKLNTPVPEGLFTINTTANTTKPPPPDPFQAQAFFRDFVNNEKQKLNLKRQALIKRKTAELVKFSQSFKLNTPVPEGLFTIRQKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C554</accession>
    <name>A0A8H5C554_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000266">
        <property type="protein sequence ID" value="KAF5334162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C554"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="277"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="728"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119555" checksum="A7248FA7121D3A44" modified="2022-01-19" version="1">MSRLCQSCERVMERTRSLRGVGQQGPAWTSKAYVHIKGDREEVFTGGPERNRTIQFRDIEGQVGKSAFCYSSVYGTLNRFHNRYEQLAIHRRRIYQSPPITGTPGYVASPPATYASAIPNFMQTPPDRPGTPGTSKKKQWSQKAIENTKMLQSGQFNDVSIAWMFASNGTIPPNAVSVATEGSQPSFLCRSFYENELRIGRLSAGPQGTRAFVISKGKERDVNEYEVLVQSFGKPQWSFIPTQSSMANNTSSQSSMNFPISQPVAPPVSAPILSGMDIVFVVDDSDSRIDLNDSVNQMIGPRWNDVRNALSGIAHACGQFDADGFDLYFLNDEYVQNNITNSDSVNQAFYKVSPDGATPTGARLRQVLDVYINKLEDKRRPTKPVGIVIITDGDPTDDVESVIVDAAHRLERAQIHESQLYIHFIQIGDDSDAANALRHLDDNLSNKYRIRDMVDTTIPQYPQTQFRTEMLFSVLQSMWKKQTHQDGSSGNGSGGGNVSPPWTGTRTFSPLPYNTVNNAQRGTLSTGGLTSEVQDLLSPISPIGTSGTNMQMQQSLNNFGQPSNYQSQYPAHQNPQSLTHGPGQVQGQGFGGQSQGYPPFSSPPSPYTSRKDWIQKAKNLTSSLKMPMNASASVPYAWIFVDSAELPPSNAIACGIEQGRNTYFCRSFHENQMRFGTVVEGSTIALVVGKNSREIQVDQYEVLVQPSGTFFTFATGPAPLPPPSSKMDIVLIVDDSDSMQGRLWHQARDALAAVAEASPKFDADGVDMYFLNSSRFQKNIRQRSVDYMYPSSRFRLGKMLFTFSTKSRQTVQYSLLPAEARLIIWSAGGTPTGARLYEVLNEYIPKVEQRSGHAKPVNVIVITDGDPTDNVENVIVNAAHRLQRSQVPERMIGIQFVQIGDDPDATQALKELDTALEQRWNIRDMVDTTLYDPLSPQFKEDIIFKVLWGAIDKQYLNIFWPMRFQLQFGALRGLEKASRSRAEEHAFLKFARLLIFLLLAALPWTASFFQESTRPFADTLELSWESVGSLGQLDKLVQSFSKLVPSFKAAVQAARDWRWQVKFIRAETGPANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7S9</accession>
    <name>A0A8H5C7S9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7S9"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44784" checksum="6281248F576D751C" modified="2022-01-19" version="1">MSNQFKHCNRNAWGRTSKAPKVPPNVMSLFNTIFDLFRRHPYERLPGSGDFRSNQAAKRQGRVLLAAKILANLVVLWILAKFLSWKGPYNPFDDYQLLNTLPLLREDRRPSTHRAAIFSSLYSDSFAIGAAVLGHSIRRANVNASLVLVYLDDRVSSQALCITEAAGWDNQAVSLLPPPHNGKGIHYRFVDQYTKLRIWSLGEKLGFDSGVYLDADTMVRRNLDELFDLPWEFGATPDVYRDNSKFVITFNAGVLAFKPSTRTFEEMRAKLETASFPLAEAEQAFLNLYFGAKMVRLPYAYNANIVVKERSLKMWEELKDTMKVIHYSVIKPFWDKSIPNDKLMTPEQVRKVNDVRAGKNGGFFREEMGWWREIFEDLMQEKGAAIDACYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9V6</accession>
    <name>A0A8H5C9V6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9V6"/>
    <dbReference type="OrthoDB" id="10500798at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="274" mass="31125" checksum="32F3D3DDEDFBEAD5" modified="2022-01-19" version="1">MSPSPSVSRQYAIAPLEAASKSQSLIVSGSRKSYGSTKHARRSIISRRLGYAHFYPPPQPLSSEYMQKQSKRRFWQYTFQRLLLVATWIFFGVVTRGMANKYDLNARARLYIATGLTFLLLVGLIYSSVQWAAEVREEHWANLAAKLGVELFRLEGMYDRSQQEEHVPVNPDFGGQVPFVDSAEGSNVFNALEAQYLSSYHRKYHDLPLYGKDNQYLRDHLEDIESGLRNLDVIEEHAESARRRNDILDLNFMGATGKAFLATVKSVKDSHPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA01</accession>
    <name>A0A8H5CA01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000204">
        <property type="protein sequence ID" value="KAF5337864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA01"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="18407" checksum="FF58A9DBD0F678C4" modified="2022-01-19" version="1">MPTSTPQHTLYTNANAIILPTKLHGNPYPVVPVPSVPVPIPVPVPIPGGTSGYTRMVTTPLSDCTPYPWAFSFPSPTSTSTPTFNLADTGGRGVRHTDTVLSMWCFRFPVSISPNASTWTPPHPTSKPVTPPILTPTLTYNPDSHANPNIVDVSSSISMSIVKANGGFTGMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA21</accession>
    <name>A0A8H5CA21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA21"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5337982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35066" checksum="D1E41CD6842FD021" modified="2022-01-19" version="1">MPCSDSESSAPGALSEAFPPKPKWTTKDMPDLSGKVIIVTGGNTGIGKETVKALLEHNAKIYLAARSRAKAEAAIEELRKETGREAIWLQLDLADLASVKTAAAEFSSKESELHVLFNNAGVMAPKIEDLTAQGYDLQFGTNVLGHFYFTKLLLPILLSTARQSPDGKVRIVNTSSIAHTSCRKLNHDSFRDGTVRRKMSSFSALYNQSKLGNVMFSNELARRYGDQGIVSTSLHPGLLSTDLQKTFPKPLKMVMDAFLFHPAEMGALTQLWGGTSIEGAELNGKYFTAWARMGKASAASDDVEECKKMWKWLDEQVADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA97</accession>
    <name>A0A8H5CA97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_016837</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000214">
        <property type="protein sequence ID" value="KAF5337584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA97"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="112"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="305"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5337584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="462" mass="49877" checksum="A172C901837F41F4" modified="2022-01-19" version="1">MVIEMATPTSLEAQTSHWQGNSHRTRSSTRKPFQHSLSRPEVNVLSIVYPFGPRFDVSNSNEASMSTSRTPLASGRMWRNISLFWLLFSFATIVLTILSWVLHFVLGDRSPTAVFVSAFLALLLQAYILGYATEQLSLSSGEKIAALLNVSFGNAVEVIVAIIALTKCELEVVQSSLVGSVFSNLLLVTGMAFIAGGLRNGVQRFSSEEAQLQSTLLIFACCSILFPTTSYLLQTLNSNADSSHVIKSLHVFSQSSSIVSALVYGCYIVYSMINSKRSSVTQESEAVSEAEEEEEEPVIGRLTALSLLFAITAVVGVTAEFLVSSLDGMTSQGPLSKQFVSVILLPIVGNAAEHCSAVMLAVKNKARMALDIAVGSSLQISLCVLPVSVILGWIMGHPLSLLFDPFQSVVLIVSVLLVSFIIQDGRSNWMEGVLLFALFANLCVAFQVYAGFQASNAVNTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAX8</accession>
    <name>A0A8H5CAX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAX8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="133"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="694" mass="77899" checksum="65BD2F270E10E6D1" modified="2022-01-19" version="1">MQGITVTQMSLCKFTVNMSSLTQDFQVLSSDFASLTSQSRNLVETLAMTDNSAGNKMFNQASQFTITQSPITVIGSNQINQSNVAGSPKDLKWINAPNPFENFHSAEQKIVQGTGTWLLEHRLFQEWKTGMSHFLWLQGKAGSGKTFLCTNVIKTLRKDSVFLYYYFDTRDKAKVDYSGIVSSLLHQVAAEAMKQNSQNAYNAIHQLYINSKEGKFLIPEDMESTLLQLMTMMDVAYIIIDAIDECAEEDQGKLLALIDKLLTKLKNCFVLVSSRPHINMAHRKAQVISLDKQMSDVGITSDIEKYVDMKLQEQDAWSPKLKAEIKDTLLNGANGQIRWVDCQLTALNEITIPKRVRKALKSLPKTLQETYGKILEQVKEELRDDVKTIFQWLLFAYRPLTMGEVQHILAIDVEEETFLPEDLVENITTELHKVVNSSLVVIIQASIEEDSWEEQNVLTVQLAHPSVKDYLLSEAAMQSVSGYFQMNSALAHEAICQMCIVYLLCCGQEAIDVEIFALAHYASKYWFLHSNQTEEECSAILDFSCKLLSTTQPAYYNWLNVYTPDTWDNKRENIIAQPLYYASYIGLKSVVVYMLEKGADVNAQGGYYGNALQAASRNGHLEVVRALLEKGADVNAQGGWFGNALQAASSWGHLEVLRALLEKRANVNASALNAARYQQHSEVAAALLELGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBH7</accession>
    <name>A0A8H5CBH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000193">
        <property type="protein sequence ID" value="KAF5338675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBH7"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22788" checksum="EEBB9D4AE8DB35FA" modified="2022-01-19" version="1">MQNQYKDAESTIQQAKRQFEGLGDRMGAAQCLQTLGDICRVLNQPKDATVMLQQAKEQFEGVGHRLAAAQCLQSLGNICWMHRQYDKAKDMLQHGRVQFEELGHWLEAAHCMCSLGIIDHKTGHILDAIASLKKAKEYIEATQMPQEDSVCVNFLQRINAFSAVLERQAESMEVTSQDVDALAVAVENQTESMETGSEKSCQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBV0</accession>
    <name>A0A8H5CBV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBV0"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48780" checksum="793F30A32BF95C83" modified="2022-01-19" version="1">MATLHTLPSTTNNEVEHRKLGSPDPSEGIEYPDGGLEAWLVIFGSFLAFFATWGVINSYGVFQEYYTTVLLPNESSSTISLIGALQLFFLYGGAPVVGRIFDLYGPRVLLPLGSMITVISLILVSFCQVNQTYQFFLADGLLFGIGVTLVFTPAVAVAGHWFNKKRPFAIGVMATGSSVGGVVCPIILQQLIPKVGFGWAVRVMAFVVMGCLIVSCVTIKTRPTLKSRLGVDAVTAGAGKREQKRISITDLVDLSGFKDPKFCLACATTFFLFYAQFIPYFYIEAYAKYRQVDSVISQYVLSIMNASATLRLLVCLLAVTYGTLNVMIPSTLLSAILVLAVWLPSRGAVPITIFAVLYAPLSGVYIALSPAWVGAMSPPERFGGRIGCMWFFAAVACLAGAPTAGAFVKDREHPGYTWLMLFTGLMILTGGVILVIARVLHSRKIWYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCQ5</accession>
    <name>A0A8H5CCQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gpi1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCQ5"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="64583" checksum="B9F0D4826CC18730" modified="2022-01-19" version="1">MCPHVFARMLTATIFYPLDCNLSGYCYGWVKPAICVAGVLQTENATETQKILDKFVKSTSANLTRINAQSLVLLGRCDGADALSGTKIWVPSLHFDCVKSNYNIVFYHRHTPRSLRYYALGVPSADGTKKPTSLPGYTFGPLSPDIQAEGSGISDKVLNQFNAAGAVDALLQPYPHSPRTLLPSQIHNLSRWFLGFVCATSSHVLSLVIRALIMVCNTPIFTSWDFKSYTILLKDVSATIQQIDVRMEQTNFLVSEISAIRRRETMPTSTYSMRYTNFFNNVWLILNDITIGYAFGSFLCENHVVLANFLSSAVESILINWIQWVLRWLDSWPAGLKLNTELSRFYSHTFVDLVEMWGSVLHRGFPYLPAVIYVFGFFSSLGGVIGGMTMSISLFSDLLSLATVHIYVCYVIANAVYARILIMVGSLWNLFRGKRYNVLRNRTDSWEYDVDQLLFGTILFTLVTFLFPTVLAYYSLFALMRLATILIQASLETQLAFMNHFPLFAIMLRVKDPWRLPGGIFFAFKVSPTREGPILTIQVQSGGAVFEYFLSIYPLMVPTGVALQSPPAAQVCICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDB0</accession>
    <name>A0A8H5CDB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000193">
        <property type="protein sequence ID" value="KAF5338678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDB0"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="327"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5338678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="491" mass="53794" checksum="9D10BAAD15EE2BB6" modified="2022-01-19" version="1">MAESNIPLEDPMRDSATDGGLDKTLPQPTLEFEMAIKMALGQSNAEEVGGTLIQSTPDHEGEDVELKRAIEMLLGQPNAEATEDSSVNYAPIDMEEQAELELLSGWESLRNQAKAQELNNSAVQLIQYFKQSGDCVEIDMAVQLMEEAIKLTPDGHADKASWLNTIGVAFLQRFEHLRELGDIGHAIQVMQQAVDLTPDGHADKAAQLTNLGSALLHRFECFGELGDIEHAIQVMQQAVDLTPDGHPDKAAQLTNLGGALQCRFEHLGELGDIENATSTYQRATTNTSSPPSIRYEAACKWATLCSHHQGSSSALHAYKVVLEIIHLTCHEAVIETVKCEMSRHEIVHLACHGIQDSKNPLDSALALYNGRLKLQDLMCLSLENVELAFLSASQTAAGNENLPEEAVHLAAGMLAVGYPSVIATMWSIGDKDAPIVADKFYESILGRSDELVSQNPRQSAAYALHAAVEHLRKEVSEMEFVKWVPFIHYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDU3</accession>
    <name>A0A8H5CDU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDU3"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034385422" evidence="4">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5339678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="21475" checksum="80559731B980A5EC" modified="2022-01-19" version="1">MANSAGTRTFLALASVVVILLLGVTAPVVYDALTNPTTQVQHSLSFHPKFPSPVAMHYEATTVHYTMQGPEADEEFAKLLPLHGHTVHLLSESGVIETFTVTLFHQLKCLDIIRREYSELYPSNPDLTQHCLTYLQETILCRPYLGLEVTKNRFATGRKSREIVCRDWEVVYAEATRNWGVYSAIVNGTGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CH20</accession>
    <name>A0A8H5CH20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_013553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CH20"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034201868" description="CFEM domain-containing protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5340447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="177" mass="18640" checksum="122473E9B6DE7A4F" modified="2022-01-19" version="1">MRFSIIFICSALPALASASPTLRLQSRVPDCAATCIQDTNPPAGCSADDNTCLCNSNEYVYMTSNCIEDTCSADESSTGMNELKAVCEDVGVALTLPVPVQKRAPDCATTCIQDTNPPAECSADDNTCLCNSDEFVYMSSNCIQDTCSSDEAEAGINELKATCGRVGVAVKLPVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CH50</accession>
    <name>A0A8H5CH50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CH50"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="281"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5341599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="752" mass="85079" checksum="3CD3BCF969041704" modified="2022-01-19" version="1">MFGALVKKILSGHTFVLPGDPSATRAILVQLATHIQDLESQLAAASNDESGASPSIPSRVAAPKSNRRKSSDEADEKDLKALSDEFDQLSVSVSSSQVYKRHYGQSSLEMFLMNALDVGKELHSEDRPIVTEWQSIFEKQYKRPEFWTNPWHILPSYTPYQFPDQDLLWKLLDIYFNHHAPVYPLLHRPSFERSLVDGLHYRNRDFGNLVLMICSLASRFMDDPRNLPHPTSPPQSAGWRWFNQIRYATDRDVREPVSLHRIQMLALSCYFLHATATYDAAWVSAGIGLKFSQERGAHRKDGPKPKKPTVERELWRRAFWMLMIQDAFNSMLTGRPRATTFEDYDLEYLTECDEEYWENEDPDKAFVQPEGTPSRMAYWNHYIKFAEIVGFAQRLVYPLRRPETKLTRAEWNKKAVAEVDTAMKKWLDAIPDHLKWEPGKKHAVFFMQSAVLYSIYHGVMIQIYRNFIPAYGQPSPLNAPALPVCVNSARSLLHIMHTVSRRGERWYGNFVGPIFLSAVILLVNIWRGMKEGSDFNAQEEMNDVHILMAILRSWELSFFGAGRMGDMLRALIASINGHIFADSTSSPAPEGQNNSSVPTADSGWQPMSYTQNQGIDQSLATLSDDSLYHQFENATVYPYGSPSHPPGAGGFNVHANGIAPDSSGETYISRLSYPTSQSYATYFQQRFFSHPAESYPAENPLGSGTSYTGTQGSHFYFPPATTADSGRNSSPESNSGWSALEQVDNSFLGFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CIN0</accession>
    <name>A0A8H5CIN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000167">
        <property type="protein sequence ID" value="KAF5341317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CIN0"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="452"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5341317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="762" mass="84335" checksum="226CE6081C591BA2" modified="2022-01-19" version="1">MTSLPPAQEVNAFTSDDRAPESFNCERCGVFVKKGNEWGYFKNPAGRDKWTCKDCKRYYSKGVAQRQDTLSRSRSTSSSTHSGMIEPLPNPDMIASRVNAAQRANASREMSHVTPMSNSGPYVSLPNLSRSSAVLSGPHGYVSRPRATGYSPAHQHHSAQTDLWRSKAYAPSGETVAVNITVGHATEGKTGHELLNGISDSIRDLDVNLTVPEVRHAVLDLMKPKINQFSAEIMGFCFKFDEFNLREISKSLNVDMDGPTLDRRTPYFRPQCMKADKKTNQLKFHWPSTPFRLLLLISAKEWDRYESLLEAQAHANDLPIIHTTSTSSSHSSWAKGLQSIPSTATSSALNTASPKTSAAISSVSMTDLIGDDSDTARTSAKRPRSTSSVTPTTPPRAKRAPAPFLSPTENRITSALIAGGLNSDQHSDISSLTTMQGLVAPIPTVSFLDIINLDNVHTRFIFDNAVLSSVAHLQADLRFESELGVGAFKTCHPAKLICSEQVMTANSVVMKELYKNKGLRENGKVVNRGRYSGVVEFDGIMIEANVHYYAVALMEFAYAYIERQKLEKGLPDLPIPNLRYVEAAVFMVQNNEIRHSRSSTAGPKRTYLLEERIALPPGQDFIKYIHNSSPLPAIPPEHPEYDTALFLAAVQHLQYEKTYQSAYVSDFQGYGGLLSDPQIMTSPLVFLILGMWWYTKNISSKLLQVIFREGAEAAALDPKTSLFGDGNVQSGFEKFPLNHQCEGNPFCAWMELKPLQNELQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL85</accession>
    <name>A0A8H5CL85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL85"/>
    <dbReference type="OrthoDB" id="3226582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="34643" checksum="BFA1E919B16A53EF" modified="2022-01-19" version="1">MLTGWENRPDSDLVLGDGQDIAASRLSVKLYLVQSALECLVYGCYMVTFGVSMYVMKFKRQNNSGIRWDVCALVLIFLITTAVTVTDLISNASLLYETFGLGGLHLGLSTTESHQFEISMQMIAEMGFILANFLSDCVLMRRCYIVWNSRFKVILFPMVLSVIVNSVIILMVVLFADDPSHGTTQKKFNVANRIMQVFFGINVIPNLLLTLLIAGRVWWIMRELEKISHDVSSEGVGQIKKRYWTTLVLILESGLLYPAALITFLVILHAGSVAPSLYPVVSTIAGLAPTLIIVRVQLGVSVDSLNDIRNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLD9</accession>
    <name>A0A8H5CLD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLD9"/>
    <dbReference type="OrthoDB" id="3032844at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1024" mass="117254" checksum="D60EC959C8139D33" modified="2022-01-19" version="1">MSDSTGNFGNTITSGVQEISALLPLLGTEQCEEHVSSGLTRGYFYVAATPLSIFGSLGLARAAFKTLVASISIPSWNFHGARILADAGFWGVGDNLPLILLDQEKRLEKEEAAVEEKSKKKSEVPLVWGAPLERRKRQKHGHNFPSPQYLAGSRLHSLLKDLRVHEDSSITVRTRCSEWNIFMIAFTAVSCLISIVPYIYLNTNNHLPPFTHWAFPVTRALGGFLCATMIPLIIEIRLRVIVEEQLRKRAKKEPKLLVDQDGQLHRFLLIFQILLFFGVVGSVAGYVGCFTVVQNSSKPQATISWLLLEAGLSIIRIFLWGVNPGYDDAPPFSLSIKLSDNPPLPTCNKYAYQLEGEAILPMVRADDFLPEIMSYVGQVERFSDPRYALYYTLTCESESSKRPLLYITVFDLTEHTGWIYTCAPPFSPSSTPSSSATSSPTFKILRARSVDVDEHNVPQAKIDVPKRGIRPLRRDIEGRVKVHYLSIMDQLMLRFGDKHIQQEGPLAQRHGITIPHRIPLEHGCETLITKWTLMTRDTRSQRLQYEANRQRVMEAVKGKLEDGAWHDGLSYLNFSSKWREIEKKVLELYHDINDDIVVCTTWLRVRLTSLGEKEQVVNWALENYWSDMEKGLLEEVHRWECRLWDCHQQMTKELDGDRLKEQAVCDWSTNSWNRLNHQVCGMEQRMKKLEYKLNARRLGWDWHHLIESMTNDHPSRDFEVSLGGYENFYLYPLSDQIHSIMKNLQQQLLQCRTSLDLQGSQSLFGCRMIDLLRLNLTRNRLQIRDKVVSSLGVDGVLKAINENPFKDTILQVDFREITDSDALVKLAAVVNDMPRLTCIRFLPLQRPITKEMVAILREIRLARDHSIHIYVGWKWDQWEETPAVKIAQANSSSISLWGFTAEGNFDEMRATKYKSQITLNFQAPTEGNVVLKITHRYASRGSSTSITIRARDKKSLMKVPVEGRNNFHTETIKLKPQDHFDLEVYNTVELIVNDDFYILQSLELAAEDGTLLLSMPWREPIPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLG6</accession>
    <name>A0A8H5CLG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLG6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="450" mass="49672" checksum="DF03EE2E3676761E" modified="2022-01-19" version="1">MPGVHEWQTTISNAHERKPVPFTTRGNTKAEAPVSMPISDAVVQSRASSSQHAGTPSAPVHRRTDHPSQPKISRSSLKQDSSSVQSTKPASSRDRPSVQAPDPFPAMGSNPRRHPRPSISISSASALSSVSASHDVKPRQERKAEEPARIYFKTLMASTVHNLGDFGVHTALLATLTAGQKVEGFNSNFILGPQQIAASNFMKEAEADGRRMGGIFAVEDGSGRFEVLARIVDEKNERKRALANQTEEVLMPLKRPTLNGMGKSNQYLARVEAKCGYLPQQTWKESVFNDDERTFESRHCDYYSSGFARAFSGEPIEKGHRLHPSNFIEGNKLLLAAGQTLSNPFGVHWRRIVLERSEAIKNKGKSKSLEAFYALQGDYRWAITAVSPFLHIAPLNDMAYFNNQIKHPIQKNTSTRAWSLLRIACSAVVLTSLEARNDSLIDAESSEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLT1</accession>
    <name>A0A8H5CLT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_008886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLT1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="282"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="448"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5344151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="61422" checksum="3BB9D5B4AF879375" modified="2022-01-19" version="1">MAKEGSNQQTLSGRDPYNSLSGTQDRVSLSKIQPNSSNRQIASPSLAEFREHEGRTNRKRRLYALWQHICRDGYLSQEHPRGRSEGTVSSLTPDKAEKLRASYEDELLGRCGAQSSRRQIGWTEFKDYAEAKETELWNIFHSELDLDGNGHLDARELDLAFRKSGIVLSSADLSEFISFLASTSQSRSISFDEFRDYFLLLPHKISPSEIYKYYEMTKFLGDDGRGPARVTMEGDVSLSAEDKPPSSNPNANQAYAIPQAQPQHEDGEEIDEDDHHAFIEHHTALKFLLAGGIAGAVSRTCTAPFDRLKIFLITRPPDLGGTSLGSKTGIGGVKMIWTAIARIYAEGGFLSFWTGNGLSVVKIFPESAIKFFTYESSKRMFAQYWDHVDDPRDISGTQMMSSAGAQKRTLVEATRHLWALGGFGAYYHMSTFEALKLAYLRSTGKDEPGVLALLAFGSISGSVGATSVYPMNLVRTRLQASGSSGHPQTYTGPLDVVAKTWEREGWRGFYRGLVPTLAKAWRMRYSTYYNTASPYYPSFNVFHLVSFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLT6</accession>
    <name>A0A8H5CLT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLT6"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034003256" description="RTA1-like protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36007" checksum="87AD41E59B41C9CB" modified="2022-01-19" version="1">MGSFSTVFLSLCLLLGFARSAFAARRPDLPRPADPFADPRHDPYNPLKYIASNVLTAVAFTLLILTGLAQTWCLRKWGAKWMSVMTIGIYTFSFGIGIRFGLHEHPESKGLYIVEYLLVVLSPCAFIAAEYVLLGRLARYLQCDQHLVVSPLRITITFISSDITTFLIQAIGGSMSISANNQPLALAGSRVFLTGLALQLLSFLIFTCIFGLFIYRVYRYEYDIFVMDAEKKWYRDWRALAGTQLVSNIGILIRSVYRTVELSEGFQGHLATSEAFFYGLDTLPLFIAIVVYVPFWPGRFITNQTRPAVEERASNDSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMI4</accession>
    <name>A0A8H5CMI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMI4"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="278" mass="31195" checksum="D8A23C7068B77CE4" modified="2022-01-19" version="1">MSTKSNTSSPYENIQKNQAEGRRLEDQYGFYKKHIRKNTIIFDEAVTMSDDAVVLDVGTGRGSWLLDLARTAPPSISLYGVDICTTFFPSHGSNIAFSEHSCTALPQGWTNKFDFVNQNLLAASLTRGDWITDIQEIFRVTKPGGHIQLYEPSCANWDCPPDSANGKMKALFKALFDSNSLMSDIGERLSPMLTDAGFVDVRAHNGTYPVNANDGRQGKEGARLTLLWLRCLQPSMLRLGILNSDREYELLIEEIQKEWDEGVPYQNHFLFYATKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP66</accession>
    <name>A0A8H5CP66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP66"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034534145" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19204" checksum="8FC9DBC9DB125875" modified="2022-01-19" version="1">MFPPCFLPLAPSFISVWGLPLALNNPPCPPRIPSVFRGVGVERRGVYPICVPALLLHLRLRFRFAYQRLFFSFRPPVPVLVSIRSVFPASPPRLPIQHLPLPICAVRHTHVAYVTTYPPTGSRFPAPLNPIHPLLYPLRRTLHAPLSIYHHHPKGRAPIQPLPVAGSAPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRB3</accession>
    <name>A0A8H5CRB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRB3"/>
    <dbReference type="OrthoDB" id="3226519at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034873360" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="20148" checksum="3DDEF33BDF178787" modified="2022-01-19" version="1">MFTKQAFVLLSALALAVSASPFIRRAELCAGQATVTESFIGKNKDVKLEEISCASGLSARALEGRQTNTSNVCGANCVTNCFTPSGGGPDPNECHIIADALRFESQNTSALFQIANGVRTAGANVVTLTFRSCESFFVNQDLQPLVYCRTDFADVIDFVAPNCQATQNAHGGNCVATDQRWFIQVQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRJ1</accession>
    <name>A0A8H5CRJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRJ1"/>
    <dbReference type="OrthoDB" id="2968776at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034046909" description="ABM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15907" checksum="3277EA1CF09FAB69" modified="2022-01-19" version="1">MFMFNSLLLTALVLVPTWAASMARGDDPQGCADLLPDFSALPNKTSSGKFMILFNSQAVEGGEARLEELVKNIQAFVATGAEPDTLTYRPVRVVDNNGNPTGAYVNIEEYTDKSALVSHLQSAAGCQFLRESPPLIASQTFTVVDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU19</accession>
    <name>A0A8H5CU19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU19"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="2">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="3">
        <location>
            <begin position="105"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="4">
        <location>
            <begin position="466"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5347086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="100547" checksum="A93B4D2437C8F8ED" modified="2022-01-19" version="1">MRGRAYVHFPMASEPISLKWVDGAAPSITPNGAAFGIPWPQGEIDKTTPIAVNAGNTSIPVQTWPMAFWPDGSLKWTGHALPADSGLSDSLSLAPGTPAEPQNPVSVSQSDGVITVTTGDFQAQINTSGTTLVSSLSLAGSVKAQNGVLVLHLQDAPDEPELTGDKPSVIGMQGRVDTVDVEQSGPVRVVLKVTGKYTGSGHDDFLPFTARLYISAGGTSIRVVHFFIYDGDQSKDFIKGIGLSFTTPLSDELYNRHVRFVSSSGGIWGEPVRVVSGLRRDATAPVLNAQFNGTATPDISTWPTSVSSEIDQLAVWSDFTLDQLSTSQFTIAKRTNAGRAASFIPHAGFGNRAAGVGYVGGANGGGVVFALKDFWQGFPRGLDIRGAAGDDATVTLWAYSPRGPASDMRHYDTVPHGLDLAYEDVGDPDPNPIGIGRSYEVTINVVPATPARDALANFAATHIQIPQIVANPEFYVSRKVFGGRWNLPDTSTSDSTAIEQKKTELLDFYVKEVDQRNFYGFWNYGDVMHTYDQTRHTWRYDVGGFAWDNGELGTDLWLWMSFMRTGRADVFHMVSALTRHLSEVDFHHTGPFAGLGSRHNVSHWGDGAKEARVSASSIKRPFFYLTTDELVGDIMDYSLQAGETIMTWDPLRKVFPPPPPQGPGRLRIGPDWVTLVGNWFTKWERTNDDQWLQKIKIGMSDIGGFEFGLFTGNGAAVGWNAATSHLVDEGGEGEGAYDLMMVFGGGELLIEAMDIITDEPEFDAAWLDFCRLYTAPDADKITRYGKTWNSGGFNQWYAKLAAYAGERLNDPSLIARAANIIQTNTVGVFPAPTQVGGQDVVEPVQEIENLATNDAAGLSLSEYAVLAIAPGLSAPGSAQARRKWVSPSSDWDRSTIAASEKAWEKDEKVSLKERRPKWKKWLCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CX73</accession>
    <name>A0A8H5CX73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Brain protein I3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CX73"/>
    <dbReference type="OrthoDB" id="2564984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14875" checksum="84D49125B09A93E7" modified="2022-01-19" version="1">MAHESYDNPPSYDAATESDGAANVQGKDLKQSEVMEYTPTRPVMHAGPSYVPGNPSPTVYHYVHPVTQEHIASLLPPDHPEMICLQSGQHVPETHYGILGLLAAVFWFPLGVGVCLLDRRLKCRRCGHVIDNGLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZK1</accession>
    <name>A0A8H5CZK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZK1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5350885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="328" mass="37339" checksum="B4809BC5128B6D9C" modified="2022-01-19" version="1">MISPTSDDLRVASCIGIPIAICATLFRTYLRRKTYWWDDFFALVSMTGIIFMWIGILMFTSPPEHHSRHFKVLGYYFVDNGFYATIWPARISILSTILRLTYPGRFRQILQVFFGLFLLVWAIMDAQIWWTCEQEVEWKDRLVAQCMLGKEVAIAQLITDSATDLLLIAAPMYLFSTLTSRRSLKIRLLTVFSSTILTTVFSLVHAYAILHDLGYLEFMFAVIEIVVSLVVVNLTVITSWLFKLTDTDEDTEPAHINTFMKHRISGRSRAGTQGLTNTIGLSAMTPAHVDISTTTERHVAFAKSGELEAGSMISSQFDEWKKLNKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D254</accession>
    <name>A0A8H5D254_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D254"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55755" checksum="BAC4354DD9C9BA58" modified="2022-01-19" version="1">MSFLIKEGKIQIVTLQDSFHLTYLPSYQLDHLQTLYEELQLASVEAGRYPEEDILMFAHRTKYFGIIIGKQSQSTEESVASGSPTRKNCRKELSVGCPVFISMVSSSLLQTGQSLKKVDDNDLKNHVNDDLYSMLNSSKNDPQDTGTQEWDDFIWRGLPSIEVLEDAPRYVQENPVQILAQSSYGILGFVFLIPIQEVCFPDAFTAAEEMVVGIILSEDHRGFGYAKEALQLVLEVGFDSFKCRQLRANILDTYCKDQLVNLFTQTHFKHVGRRRRCYYSVLEQEWKDVTSFAIRDTEYYANRSYPQRAAPATLLVWNEVRHSDPFHLQRTSSMETLRGSSVSVGTTGASQSDDEESALESDGWSSPVVVGKGKRKIWDTDEVSTSDGWSSPVFIGKGKRKLGDESPASTRPGSPCSSERSSGSRIAVGHKLRKLATDSVGATNSDDDDYGSLLSFPSPPPEVPPSPVFSTFSSADSDASSNWSAQTSSDWALLESASGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2M6</accession>
    <name>A0A8H5D2M6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2M6"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33712" checksum="79043B1F3A6D9884" modified="2022-01-19" version="1">MRLLRTSTPEPVLETFVSSTPPYAILSHTWGNDEVLFQDLLNDARRDARRSEGGPGWQKLEASRRFARERGFEYIWNDTCCIDKESSAELSECINSMFRFYSESSLCVAFISDVSFGNMDQTARKKEFERSRWFSRGWTLQELLAPSDIVFVDAGWAVIGLKSDRDLGKHIRQATAISSEGLADPLSPRISVAERMSWASRRQTTREEDIAYCLMGLFQVNMPPLYGEGSYNAFLRLQLEIIKLSRDRSIFAWLASNDNLTHRGLLANSPQEFLASGTVRFSAESQIGQVVATVGSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3M3</accession>
    <name>A0A8H5D3M3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1438" mass="152544" checksum="55F6753E44218EDD" modified="2022-01-19" version="1">MSPSQSRGHGKLCLDSHAGFRDTLQSRQNNAQTSLTLDPAVIANGFSDDGQDPPVDGETRSLTSSNNFINYCALFNLPLTNGTQNSRFNATCNPVPMGALPSVDHMPSSKIRFPLNGNTLTANQDFTISVKINNLNTGVFTVAEVNYLSAPQQLDGDGLILGHGAVVIEQLDSLRQIATTTPGLFSFYKSLNIASQAGVVNANVDSGLPSGFYRLSAIVSAANHQPVLVPVVAHGAIDDFVYFSVTSDGKPPTSLGSQTARDAPESDVVVDLTNTGTISLQSIITVDSSVIGNFTDEGPRVEGSTPSLTSTNNYINFCLNFPSLPLTNGKISVNASCNPAPMGLIVPESAMPSVKFLNPQHMDNIPANSTFTVQLKVSNMETGVVTNADKTYLSAPQQINEQGQVLGHAHIVIEELTSMTQDDPTNPKRFAFFAELGDVAKDRVLEKNVTEPSTDFGTNFATWTLNDMVYFTVGNGGDGSTSANTLGADAVSTSTSTTASSTNTGSPNSPVSSSRHMNIGAIAGGTAAGVIAIALFVGFFLFHRRRRLQAARQFTTDNPVSPSSELANQITPFSTLMSASNTNSTAGLVSQPQAGTKPGRIPPVPVIYPAGNEKSTQRSGRRGQTDTSISPGPSNAQMNSPGYSQDLEQTDSLPRSASNGNETRDGRISPRESISNVNEKEHLALLAARTKDRHDYVPTGTHGNIDTIELDSSRNATYCFLSLSCSRLPKTRRSFNSSAQKSSPRSDLQGRQNNPQTSLTLDPAVIADGSNDDGQSPPVDGETRSLTSSNNFINYCALFNLPLTNGTQHPQNASCNPVPMGVLPNVDLIPASKFSFPLNGDTLRANQDFTISVKINNLNTGIFTSADVNYLSAPQQLDEDGQILGHGAVVIDILDSFRQNATISPEVFAFYKSLTIPSQAGVVDAVVSLPPGFYRLTSILSAANHQPVLTPVLAHGAIDDVVYFSVTTDGKPPTNLGFQMNQDARESDVFIDLTSTERISLQSLDTLDASVIGNFTDEGPLGVENHTPSLISTNNYINFCLNFPSLPLANGKISFNASCNPTPMGLLVPGPAIPSIKFQFPRHLDNVPSNSTFTVRLKVSNLQTGIMTNPDKTYLSAPQQINTSGQVLGHVHLVIDEISSLTQDVPTNPRQFAFYAELGEQAQDGLLEKNVTLPDGVYRLSATSVAANHQPVLATVLQHGSSNDMVYFTVGNGGEGSISANTLSPGGGTGTTITFNSVATSTTTENSAAFSGSSLSPSPNQSSLGSSGSHLNIGAVVGGAVVGAMLLGLLLGFFLFRRRYHAHESRQSIFDNPASSSSRREPASQITPFPISTSVSNRRAHDPTKTRRVPPVPGQYLAHSLGKSARGSGRQDQIDPISPPALSNDGTRATSSSGHPQISSLSEDHNGSSAHFASTHLILRRDSVLSESSQAPSYHTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6D5</accession>
    <name>A0A8H5D6D5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6D5"/>
    <dbReference type="OrthoDB" id="3027122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="729"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="771"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5354497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="918" mass="103123" checksum="061F124C6DD477D5" modified="2022-01-19" version="1">MYCIHLSFDGVAQDGNFQNQLTGCLAPSEKAEYNAMTSAPRGPCTKGTRQEILEKLMAWAEGDTDHPIFWMNGMAGTGKTTIAYSFCLQLLEKQMLGASFFSSRSEGETADPGHVLPTIAYQLARHSPEFSAALRKSLKAEEDSGCTPSESQFRKLILSPARTSRSAFGQKHLVVVCDGLDECRDLSQISKILSLLIQHAVDLPIKFYISSRPEADITARFTGANSKHHKKFLLHNVEEHFLRRDLGLFLHYRFAEIRSEKSISEEGWPSEDQLNQLLDLSGQLFIYAATACLFIADPRIQSPGSTQKALRDILSYSASNPTPGNEASYRELDALYRIVLSSALHNDEENEVLKNVLHLITTAQTPLSQTAIAELLQINISSILLERTLSSLQSVISVPANHSQPIQIFHASFPDFLSDPIRSKEYHHAPKESHSILANKCLEYLKGHLVENICGLQDKNVHVSQATIAGNISEALQYACMYWITHYLEASDKDTLHELMNKFFKKWVLQWTECMSLLGRLDIVVKMLRNLERAQFVDAKIRQLAGDTRRVTSLAPVREYMDCFNTIRDHPLEIYYSALFWLPKKSIIREFYPQEIPWKLLGGVGNVWECYDHVIQAKGSIYCIALSADGQQVVSGSSDSTIRIWNVETGEEEKKLEGHSHWVRSVAFSADGQRVVSGSSDKTIRIWNVETGEEEKKLEGHSDWRVVSGSDDKTIRIWNAETGEEEKKLEGHSDLVRSVAFSADGQRVVSGSDDKTIRIWNVETGEEEKKLEGHSDWVRSVAFSADGQRVVSGSSDKTIRIWNVGTGEEEKKLDQHSQSAANEQKIATDVSHYLHDHQCLFMCLCLCLPLNAPSPPSAHSLLPSTPPHSHFQVNNSLTRSPLIPHPHLIEHGHGASRCLKWKKEKAKEMENWIIDNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ET34</accession>
    <name>A0A8H5ET34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012872</name>
        <name evidence="3" type="ORF">D9758_018565</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000552">
        <property type="protein sequence ID" value="KAF5311397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ET34"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035101625" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5311397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5338250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="22060" checksum="B158C25C89743868" modified="2022-01-19" version="1">MKSFTVILTALATIASAQTNNFSGTVSLGSSGKCLRATSNSDNAAVVAGDCSGAADTQWSFNYGTVRIFGNKCLDVTNGNDVNGQQLQIYTCYNGNTNQQWYYNNNHIGWRGHTRCLDVTNGRFQNGNPIQIWDCIPYNSNQNFIWNTVSPSNPGNPGGPGCPAQGAITPAATTVTITAGPGPTVTSTVTQQVTTITVTSAPVTVTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEJ0</accession>
    <name>A0A8H5FEJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000265">
        <property type="protein sequence ID" value="KAF5334210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEJ0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="38300" checksum="15BBBB93201A15A2" modified="2022-01-19" version="1">MSSDIAPADQISSDILERVEDVLRRSPESIDDFTVEVDELITEILNEYGDESDSCQDTAYTLAYILKLTNEFNFMFIKPKIIRDIFLGGGSFGSVFKANYNNSAVALKIIDQAFTDKKYEQLKTWFSRELRHWRDISNHDNVLELIGCYAEVNEGSIEFGLVSPFANGGSLSEFCENRKVTLAAKHHHLVSISLGLQHLHNQREALIHGDLCCDNVLVHDEVVKIADFGLSKYDAGISTLTMQGYTEDMNFERIGPGVSSRTKETDIFAFGSLAYELFTGSTAQFQLAPYTWPSRPYVLGDARWDDLWRIVEDCWAKEPVNRPSAKDLVSRLQRAAGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FG75</accession>
    <name>A0A8H5FG75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FG75"/>
    <dbReference type="OrthoDB" id="3063557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="606" mass="67875" checksum="E421F19E996B90EA" modified="2022-01-19" version="1">MSSSLFAHASHFVIQGSSINSVAGNQTINVTNQFFNGGGLDATFAAESAFSEYRHFRIGDLFLLREVSQESVDDKHQFYTYGLRPREGFLHYTRTTSAAKAIGTEGVPPSTLVMYGGTDAYGAWKRDFDHYSQSHHPNVAHLFGLNPSRSHPALLFFDDLIPIMKLWSEASPVLRCLIEDRASTDLTHVMLKCGRSFVRETTLITGSLFVQPATGMICAAPYRSSSQVLSHTLKTYYASVTSECPPLPLTLYKDQEFQVLKFLDGALPTNYDFHVLVGNLCGSNSYDTLYASSKVLPLSLGSVIHLDASGNAKKVGQFRNVGFSPQSTRSFPAGEVMNNGWIRCALKELCSTPSCISRHGPGENRIPWIRLKADVSLRHAWLSQAQFLFNVRGRVDSWGDYALVDRLWLHLIPDNLPSFVPRIIPDEVYLFIAPFTITSSSGQQFQSHSEETLLDWGENGDVYYWSLDRSGSRKLSRKVCDFLGLPTFTGRVEVPRWSAHHYEAIRRYQYYKGYDPYSKEYAEAHGFPLLDVVYGGGSVDGSARFEEGSKSIDAASLSTKSSRRKSKEISKAFSGAWKWIKRSHKVKTSPSGRHSKRKRKGRRLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHH1</accession>
    <name>A0A8H5FHH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000222">
        <property type="protein sequence ID" value="KAF5336762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHH1"/>
    <dbReference type="OrthoDB" id="2675435at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="78" mass="9128" checksum="7463DD6CF95CA78C" modified="2022-01-19" version="1">MSVINSVSSLTPFFLNLQTVKYVKVACFALLIYDTIIALDQEYQHIWKKHWNLVKILYLYSRYCTFIDTGIAIYGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIY9</accession>
    <name>A0A8H5FIY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000195">
        <property type="protein sequence ID" value="KAF5338546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIY9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21055" checksum="C0AD28A9DA1A3C73" modified="2022-01-19" version="1">MLPALAMTKPPPSPWRIGELIRVPLLGIGISSAPTSASGRFEIRVRFRQRQGNNQVSSPSPSDNAHGIDVQIFTSRLQAPTQGNLYALLCISGFTIPHNRRRRHRQNPDVLTVMLVTLVTPVTHTKSERPNDLNIPDGLEAAGSGNISMVWFLDDKTYDGSERTRSICVRFEAFGEASYMIYFALCGVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL79</accession>
    <name>A0A8H5FL79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL79"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="555" mass="60594" checksum="5D55B514F592F480" modified="2022-01-19" version="1">MNPSFFDHPFPQTTTTRKLVSPKTSQTLLDRGISEPISGTVRLEAQPGLPAPLHHSPAQRSPNPLSVNQSSPDMAISHYNSPNSSSRIVTNGKSLTPVDAAGDPDAHDFHSSIPSLHTTNSTTTTNFPPSIHDTLQSNSSKTPDPDALRNILSPIVLRNANSRLQQIRNGNGEGERQLENVKRTLSDDVLHNFAATMYKAQSQLRERLQEKSRRLAPTEPRSIRHRSRSGINWGTLSHAPDLRNGHSHAETSISGGSYQPTGAVRDGHRHVNGHTHPYAYQENQLGPSKRRSRTRTSSNASISPHIPSAPIPSTSAVTGEHIPVDQDWDIAIQSVDDPLPGKLTEHGVEAVSTTSESRGQIPTAEQTALEPPDVPGIWSFKVALPEPGILKWEFLLDPTTVDKWHLHPTPTTYDNLMESQPRLALHLLCLDSEALPSSRMVENEAEKMCAPWPTQGTLIIEVNKKQEYGKTILPNHLGPNASAFDITKMVHPGHNTLCCIQLAPMSCIFAIHAGVVGPPPDMSHLSQFVDKLAVQSNDSQAPSADVAFHPLQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQF2</accession>
    <name>A0A8H5FQF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="221"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="645"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="757"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1281" mass="143810" checksum="E50A3ED0431C229B" modified="2022-01-19" version="1">MAVEIIDIHVHSDADNALSMRNEVLKSLSRPIGEKTLSTMLLYDERGLRLYDDITTKTQEYYLFGAEEEILKNKADEIVRVMHHETGVVDGEITLELGAGSLRKTSHVLLGLSHLVQKPSVHRPPITYFALDLEQRELERTLNEINMSDVGKHLEGKVATKGMWGTYDDGLKYVENTGLHVASERLSRGPTGQFGNRDSSPESNNSDSSRSRSQDTTSSLPSTPDDVQHPLHILFLGSSLGNFGREDGADFLRALPLRPGSTDTLLLGLDHDNEKELVEKAYNDASGYTKEFIMNGLKAAGRVLGDESLFNEDKWEYVNKYDPEKRRHEAFYKSKTAQTVQAPSSADKFEFLEGELVKFSDLDAYRLFSESNLRPIQRWTDSTQKYSLWLLERPAFTFPLLSSARACNTSGELVLQKKFSTSLFGVPSPQEWENLWALWDLITLRMIPPSMLYQKPIDLRHICLFYLGHIPAFLDIHLSRLLQEPHTEPEFFKDIFERGIDPNVDDPTRCHSHSEVPQNDNDWPTLSSIQQFKARVRARLLGLYEDINGGKRTLTRKVGRVLWMTYEHEALHAETLLYMLLQRAGTGTLPPPGFSTPEWTSLSSYWDSLPAPKESTVTLGPAKVVLGHDDNEEEDDVVDDAASHEFGWDNEHPKREVEVAEFRIEWRPVTNGEFYQVYKNNKDQKFKLPASWIEKDGEIQVRTLYGPIPLKIAQHWPILTSYDNLSTYAMVKGGRLPTEPELRLFLDKFESGYEGGANVGFQNWHPVPATTGTTKAGGKGHNGGVWEWTSTLFDKYEGFVPSRLYPGYSQDFFDGAHQVVIGGSYATVPRLAERRSVRNWYQRNYPYPWVGARVAHAFAIVRSEVHMVDRAQPRENERRLALSDKLRSRPTGTWVKVAKNGEFRLKLNSQNDSALPVYGLGSPVDGAVEVSKSESVLSVEVKVEGRLRLKEIAESGAVSAKLCLETALLWTKDPSGTSCPPSLPFSLSLPTTFEFNRKRYPLPPTYEVKLSGLPGFHATIDYTICVVINKPNNTVPILSTNLFGINIGNMTLSTSFIYYPRSRPALGPAPPLRPIHDRFQPSTQWSFYDSVIHAANSSMAHINTRLYLPSSRIFCISQRIPFYLTLQSSAISLAAFLPLAPSSLAVNRRPTRVQILRQATVDVRNEVVSGTKTDMWRVDCIGEATFGVLNDGPTWVTFFAEIAVDTSVKVAGFKAGGLSVKDCVLFSMTPIDPNKAPFKELRQVIPIRLTTDEWIADGSGSSNIPSDSQYSIASSPENGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRB3</accession>
    <name>A0A8H5FRB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRB3"/>
    <dbReference type="OrthoDB" id="3087061at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="191" mass="21463" checksum="4D215C6B84F4B48C" modified="2022-01-19" version="1">MSAQNTTVLPYSPIGSPSIDALGARCHAFYTALESATSLGPEIAQFLSPDFATIQSPTMPFNASVYPGLLGALQIAEQEVNWFRSNNTVIRVFTLGESHCIAYGVDHNATLVDNSLGTFTLEFLEHSYWADDLMQSVKFYIYDMYPLMRGQMLEKGAQRYVEWKDRDDKQKQAAIDGFNQEFPLNYDPHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRR6</accession>
    <name>A0A8H5FRR6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011099</name>
        <name evidence="5" type="ORF">D9758_011105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRR6"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035101630" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5347200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="559" mass="55022" checksum="DDF02E5D505EC86A" modified="2022-01-19" version="1">MKSFTVVLTAFAIAASAQTTVFSGTVSLGNSPGSCIRAVSNTDNAAVVLSNNCTGPDAQWALTNGNIRIYGNKCLDVTNGNDVNGQKLQIYTCFQGNTNQLWQYQDNHIAWTGHGRCLDNTGGNLTPGNPIQLWSCISYNTNQRWSWQNTTSPAGAPAAQPGSAQPAAIPAAQPAAGQPAAQPAAAGPVATVVVVIQQGGGGAAAPVPIQTVNPQAPTTVTVTARVGTATVTLPGGQTTVFPTTTTLLPNATTTTGITTTTGNATTTTGITTTTGNATITTGITTTTGNATTTTGITTTTNNATCVPATTVIPASTTVIPAITTSLVPGTTVIPAVTSIIPAVTSVVGGATSIVGAVTSVVPAVTSIIPAVTSILGAVTSVIPAVTSIIPAVTNIVPEVTSVIPAVTSIIPGVTNVIPAVTNVIPAVTNVVAGVTIVNPALTSVIAAVTNIIPEVTSVVGAVTSIIPAATSVVPAVTSIVPEVTSVIPAVTSVVPAVTSVIPEVTSVLGAVTSVVAGATSVIPAVTSIIPAVTSVVPPGTTVIPAVTSVVPAVTTTICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRX9</accession>
    <name>A0A8H5FRX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_010133</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="512"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1497"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="680"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="739"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5346904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1598" mass="178486" checksum="1C59C9AE56385236" modified="2022-01-19" version="1">MAEGGDGNIKVVVRCRPLNSRELARGAKPLIRMQGNQTFLDPPEVGSQQDAKRATERKTMPFSFDKSYWSAGPRDEPGYCSQQTLYDDLGKELLDHGFAGFNASILAYGQTGSGKSYSMMGYGPDKGIIPLTCSELFVRVEDRKAKDPNINFTVEVSYIEIYNEKVRDLLNPKNTGNLRVREHPSLGPYVEDLSKLVVGSYDEMMTLMDEGNKARTVAATNMNETSSRSHAVFTLLLTMKRHDVDTNLDTEKVSRINLIDLAGSERANSTGATGQRLKEGANINKSLTTLGKVISSLAIASANEGKKGKKGKGDDFVPYRDSVLTWLLKDSLGGNSKTAMIAAISPADYEETLSTLRYADQAKKIKNKAVVNEDPNAKLVRELKEELEMLRARVSSSAGEDTFDPKVPPEKQKVTYQTKDGQIKTVTKAELQEHMEQSEKLMQSLNETWEEKLVRTQEVQKEREKALEELGISVEKNMVGVHTPKKIPHLVNLNEDPLMSECLIYQLKPGQTMVGRLDSDKPAAIRLSGDKILEEHCYFENTDGKVLLHCLPDSVTFLNGKRIQPGQGYKLRSGFRIILGDNHVFRFNNPEEIRKQRDRATMKSNLHLSVTAGEIEGGGESSPATRPESPDSPIDEDDADWTFAQREAAIARLGLDPTLDNLPDDDLNKLFDKVSKAKTLRERHLEPRPESSLSRIDDVWSESGRPFSSDATTTDDTSVVDMASNHVSPDLNEPLRDVQNQLENRLQAIAETSVEAEELKEEKEHMEHQLRLVKAQMKRLIDARARGETDLESMDFEPVMYTARQLRLIRKVLDKWRAHRSFSMAEVVLSSAVLVKEANVISKELGKEVSYNFTISSGGALAAPASSVDTIAGLDQFGDVSDPVLRSATQPSVAVKVLDKRHNSVYAWSLDRLQQQLQRMRNLTIYIDRPSYTQHFSSDEPFYDSPPPEYSFIGNALISLAPLSRRMSSTSTVPIFCRYTAEAIGSCRVDIKLVNVVLSQKHLNGSTPSTRSASPAPDILPSGSKLSFFLTIDSVKGLSLHDFRSVHLQVRLSSFVGPTFASEEVFPSTLVDLESSSLSELRFRRSFSIVASTKVLNHLRQGYAPIEFFASVTPTYLERLERWDEMREQRNPPLPSSDSSSSSSDSRPPSLPHMRRSETDFVVEQTHDVVAWIQLCELGPDGRYLPVPVVSQSSLDPGSFCIHQGLQRRIVISLSSNSGQQFPWTEFIKVRIGNVRLLDAKGRIYDSTSKPLVTLPLLKDQEVEFKPDGTGMITGQVVWDSSVHDSILLNKVTAANQRILLQLTWSVAVETCADPVQFSIDIGITIGTRDARPPSKFLSFLGSTKILTKSSSLFRVRLTPPLTRSPKDLWRLDTAEKYVRGEEALGIWRPRGISVVEDYNRLISMERRAADVQAIRVILSSVPSRPIQPDALAWRAESLLKKSLDLWQRKFGHMGDIVLSQDPSEEDIPASKKLVDLDSLEGLKLMSETKIVPRSDGPTKKGYLMILTDASQNAWEKRWFVLRRPYLHMYAHSNELEEVGIVTLTGVNVESDRLKEMLLGKPFSFTLFTSSNSHALAAPNLKEKQSWVAKLDPTRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTK9</accession>
    <name>A0A8H5FTK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTK9"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5348701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22156" checksum="4529FAF2F2B58426" modified="2022-01-19" version="1">MKIFSISVILAPSQGSSTTLASASDLSSFSFYQKGSVGEFMTFFSKTVAERTQPGQRQSVQENNYTAHAYNRGGPEQLAGVIICDDEYPVRPAFSLLTKLLDDFASKVPQSSFSNPSAILFPEINTFITKYQDPSQADTIMRVQQELDETKIILHKTIEGVLQRGEKLDNLVDRSQQLSAQSKMFYKTAKKQNSCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTP4</accession>
    <name>A0A8H5FTP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTP4"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5349345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="38329" checksum="C45C880B0A410F84" modified="2022-01-19" version="1">MPLEATMMIVDNSEYMRNGDYQPSRFDAQADAVNVVFQTKIDSNPENTVGVMSMAGKSPQVLVTHSKDLGQILQAIHKTSSSIGGQIDIPTAIAVAQLALKHRENKNLRQRIVVFVGSPLEGAAADEKGMVKLAKKLKKNNVAVDVVCFGDGIEEPGEDGKTVMKAFVDSASSGDNSHLVVVSPGPNLISDALISSPILSEDRSASIPAELGGTGGGGGPSTSGPSNDFEFGVDPSLDPELAMALRLSMQEAQAREAAETAAASSSSDSSAQPATSAATTTTSSSTAAPKTGTTAATASAPADPTEDEEEALLKQAIEMSASADQDVDMDASTPKPSSGDAAPMDEDEDEEAAIARAIEMSMQEDEQGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWM5</accession>
    <name>A0A8H5FWM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWM5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="93"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5351523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111839" checksum="9F83C54CBFFCF29D" modified="2022-01-19" version="1">MVFRTQQGTQSQTFKPPPPDFSLNLLEVHDFNAEHSPNHPLFRYMTDDEIAQTIYWGEAVQAFHVAQGFVQTLVKNDHIDSQPPPVIAILATLDSITYYTLLMGIMHAGFVPFPLSTRNSETAVAHLLKVTNAVYVFANLDNAMQSLAQNACHQLGEGHDIQILPTPVFDDFYKPTQKDFKSSTSSRKIELDDTAFILHSSGSTSFPKPIKISHRNFLAHGIEPYYGETDYCGQVTSAAGSPMFHMMGVIHVPQTAMVGVILGVFQPKNIPVIPTPENVFKNALVTKCIIMMAVPSMLETWAKDPVKVEVLAKYRVVFFGGGPLVPAVGNELVKKGVTLRTGYGLTEIGGVSNMSQQAFKEGWEYFSISPKIDPVFLPVEGMDNIVQLIVKKCKTHTPNVLDTVIDGQPAFDTKDLLVRHPTNPSLFKIYGRADDQIMHSTGEKTNPLPIESLLLRDERITHAIMFGRAKFQAGVLITPSDALVFDPADTVKLAEYRNLIWDVVQRANDISPQHSKIFKELIVVTTPSKPLELTAKATPRRGSSLKAYEEEIEKAYQALEESSQPDIQAPTVWDTVSVHEHDDLFRVGADSLNATYIRNTITRALRDAKSEQMPLASIRALPENFVYDNASVAALSKFVLDIPYAYATGTGVGEEKHKKEDGGDDDDDPEGDYQWPKMGQPGETILQVRKGKGEPPLMIIHGAGGRADGMIHFQQKFRSALWLFQVTPDLPRKSLREHAEFYYRKVKEVRPHGPYRLAAYSGSHLIGFVMVEMMLKDGEEVIQFDLIDQSPSFMFSGLNEDGRGFADSDSVQTNGNGTARPDRPPMEPSFPNPNFDITSPSFRSTYKSRMPYGLYGMAAREGRTQILGVLIDAWEGRPAPDVLVKVAETLKWYADESWDFVAGLPGYQESNVPQFKNTWERCLFAIEHWLKNISGISRVPITVYVASYGAIGSVKDKTEKEKWKESGLGVRRCFPDARVVHVDTGHALILGNTEVIKDLQRGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWR7</accession>
    <name>A0A8H5FWR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWR7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="119" mass="12795" checksum="F76E987DD85D16FE" modified="2022-01-19" version="1">MILPYSFTFTYINPVLTPGSPSQPLRHLDQRSPLCDTKRAFLSSMVSISTSQAFVGLVRFGGSGSVASLPVSADFNAIKVFKVALCITLAMCNHGFVPQDSCSACTDIMQVITKAEWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYL3</accession>
    <name>A0A8H5FYL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3056903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1247"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1673"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1680"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1700"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1733"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1754"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1766"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1781"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5354475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1804" mass="203714" checksum="AE62E6B7E883E3D0" modified="2022-01-19" version="1">MRKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPPEEYLGNPDSGEEKDNGNASDMDIDNGELGCPEVRTMPPVNESCEDKSGLQHLPTRRDETQLQTLKLFNFKSIAKAMQPSTIPTDPQSNVIPSKSAVVPSVQSTSHSVGNLQKPLCPPTTVASQTVPPSSSHPPAVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATRNCKGNNGKKNQKGSIHATTIAGGKESYKKCLGVLRCTNPQCQVITRPKIEKKILEAQCLNEYCICGFSLEHFDCGAMSFLIEYAQVGDDITTRLYRYIHAGCHNHPRIPYTKHLTAQEAKDTRQHLGNNMHKKHLESYEGGETLDGPTPPAPQLAQKFANIETYRYETKKMTKGATAEVGWSFINQFHSWIQQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAELVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTAVIEAIAEAAHEHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTVLENAAQSLIKGCRYHFEKSVTRVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQRKMDSKLASKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDRSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMYKGSQAAVKAITKLRVLGPHLSPGKSQQQDISNCLGGRLRTGSSQFSTYPQWRFHRKSRVAGDATQRRAPMIQTSIAMGSARKWSLLAGYHLYSSSDQVWMKKAINQIGISLVNYTQAQKPQVQEMEWYTNLWHACSQTKHTFGGQSAVFSYDGMENMGYSQLVKGKIGDLLAGTTGYQPDGYQTVCAVYSLKGGIVAQEKFHEDCVKIALQKLDLQLDGTRSTTLTKPGYREMTREETVNWKPHISITEYQQTHSDSRQVVKPEPAHSYSPSPGPSPTTPLRTIPSSSPPPSTPLPILCRCGVENDGHRELIKQVTVQCDKCHRWSHLACLVNRMEPTIKGEFLCHVCDPASMLDTSSSQIIESLKQGVQLRANVAKRLYAGRTVLVQMDANTLFYYPGRLLHQEKGKWTIKMWRGIKHENANKVLENISVKRLVDGLYGDHEGRRSIRLGRFIRTHEERDPADIASDWQVYQYNTEVDRALYKHKAMLQKILHHTINSEFSALSVSSVPALALYLNEGNPGYAIFRNHQYMTAVTLFRRPCPAYFTGGITTDDQARILNWLHINVQSFLSAPPKDFELCIAHARTLFLAHCHRETFLGCIEAGLSELEREQSVLHQAWQRLVDFSGKTVDGKMKRLKADVDREALQILEKVMFDRSQKAGVAGSEQWGLDVGPPEDLWWPYDGPEKNDPDLHVATESDLEESEICKAEREKMEQKVREKEAEKQNHAPPRPKPRPLTKEQAAERSKKALQEAGLTAERPDLAKEKVVKTLQTVQENAQLRRSKRVADQTKETEETENNKKSKKQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZD2</accession>
    <name>A0A8H5FZD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZD2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="119" mass="12940" checksum="7CACEFDD0C71B083" modified="2022-01-19" version="1">MTALRALIQTTIIDHIFSRVGSSLARIVHTDASTFLGIFSPPHVIFPLYNWWYPNQHPASRWSEGRGGEGPSPPTPYVTGSHPQDTHPTSPPGPTSPSPSSLTQARTAAAQYNLKPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G349</accession>
    <name>A0A8H5G349_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anaphase-promoting complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_005889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1563"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1693"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5357388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1931" mass="215791" checksum="DC22BA0A82D1A1FE" modified="2022-01-19" version="1">MNPLVSIPISGSQRSSVKEHLKSLQQNSPKEHESDLLQAIRNALRGTGVDSTSTVHSVCLTTQTDPWEEEELTWDETTVVSSCNGIVRKKWTFGLEGQRVQWASIGWMEYSGKIALDHFAQSSTQPVKSAPAEGTFGPFFHSQATKPVKKKEHRTRVSAVFIFLRNFGKIYLKNGVEFTFHLPYIVRKAWPLSPHGVLVQRVLVPGEIAEDGDDTLPTIFSITSPFQEPGSVNFASGIVGGPHVTPSLIDETAETGTQPLKYIPATEEILWVSHRNPASPFEIIVSVDPGKRQLAIWRYAYIRPKDSPVLLGRDGAKNPDAERKKRASMPGPGSRRSSMVVPPMPEDHLSPQGMPVPLPEVPLASLPGMPPALSSTTTMESITAFHQQSQGFGQPDAKKDVPRRRNSFTRTDLTATMNRMVLNVATSTGDSLLPVEQARMKNAIWLERIYVNQLNEPDLKEFRSISIALFDHRWDHKHERSLLAVCLPVQQKVTIFVLGVDKHGRLKATPTYSVPALSIAPVRATRPNVWDLLIHKPEKGLWILTHGVQELYVAFSSQTPAGGPPLTHHGRIKSLANESGCSAFVTVNFEDGWSSHENIDLLPQDLLTQQSLQMLALTLPSITTFEIHRFFFFFWSQKSFRTSDGIEWDCFVQALYTFFCITEDTAPGNTENPWQALQASSSSPARFNEDPVFQVLKLPQRVHSPSPITKVPIDKNSDLYARLIVTLYALHTLGEQLRLLVHRYACLLRLVPVICRLAMFIRPEWADYWRRLCPDALAQTPWPSAATAPVEDFDDTIPVWPPDISAILFGRISNPEWKVPWLNAFELAERFKVYPSCAYGHLDPLSALQRLSAVVKCLADGSISRTSKRAENAVRAMVQLGIGEDFISKLPLGIASSLKEAARSCQIAPPLEWPAAAYKAIGREDVAASVTQGPDLLSKDGYLSMKEYTNPNRPRRTINQIVQAAKIATAGEVELSTGVELDLEEFTSVRFGQDRRLDEVARMLCSSTPAVVKHVERPDVNEHEQAKDQQHQVLRVTERTLALAYGRAMFTFGSISTINKETFKIPKLEFAVKLQPLGITVVPELAKVTPEAVQWGEFHNGIAAALRLSSSTTTSIDSSWIAFNKPEELTPEHAGFLYGLGLTGHLKELFTWHTFSYLTPKHDFTSVGVLLGLAAANLGNSNQHVTKMISVHNRALLPTPDVDLGVSLLTQTAANAALGLLYMGTKNRRMAEVSLTQISRKDLVQQDITTEYREAYTYTAALAFGMIMLGKGTTIPADANLLQRLTLLIHGEPESKKRPTFDINLTSPAATLALGLMYLRTERQDIADILAIPDTPQSLHRVQPSFLLLRTLSRSLIMWNKIIPSNDWIASQIPPAIRKGIENRSHYSSTIADAWELAYYNIIAGCCFAIGLKYAGTARQEAYKTIIRYNDLFTRMVFSNGPSFDYRIKRSAVRDGLNLISIALSMVMAGTGEITCLRRLRYGYGMYSQTMAHPSFKYGVHVATHQALGLLFLGGGRYTLGTSNAAIACMVAAFFPRVHAASGDNKSYLQALRHLWVLAVEPRCLIARDVETKEITYLPLKINMREGKEQGQTQLISPTLIPDLDRLVSIRVDTPRYWPFHLDITNVSSHRESLIRSQTLYVKRRTAFLSYTEDPRGSRSLFVRTRSSAGDAATLDFPQLTDLKTHPAGDLWEFITSFSNDPLFLAFADHFCCITGGTDQEKLFNTYCHAVLYDSILQGKPQTLQSHLTLFRYRTMNPTSRYFHLRLQDLRFTADFYSKIFERRFSGRSENNPRPPLIRDSTVYGSLLVLDRQLDEIRTQPDFLRVLGMYALGQAADMDRVMSSYFAWYLQRNSVPVSTLLVILQDLANDAFNQCFEAPAPGGCDDARLLNIGIREVLHATGTRMTTVLGSGWSVRSLDEVLRIWRNHDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5F2</accession>
    <name>A0A8H5G5F2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5F2"/>
    <dbReference type="OrthoDB" id="2976199at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="36299" checksum="F5827CD1065B86A7" modified="2022-01-19" version="1">MTEYDYSPEAYQRHMDTQHRIAKWVDNTNAHAHEFRHPFGNRSESDKSSSGPQNRDGIEYRDGRGSRMSVRGSGDAVTRRRNSFTYQPGVSTTKGLTTTTVNRTSYPYPVSRPQIPIPSSPVVPPPKPSPAPVARYTNAPTPTRTQSRPRSLSQSYISSPVTGSTIATRRDPAAHSSHPSRSQVSRGVSGSQSHSRSRSVQTSSHAPHHPSTRAYANPNTGHPPTRSGTYPMSSSKHSHRDSYSSSKPSSSHVKTHHNHTRDRSYSLSGSQARPTLHTTQTPQYVEKSGILLPTSSSRKVYTSSKPMVVGGYTIIPQGKDERILTLQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5I5</accession>
    <name>A0A8H5G5I5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5I5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="110" mass="12465" checksum="44BD44431AE46B7C" modified="2022-01-19" version="1">MNDPKHNHTFFIVEEEVKKELAARALISGNPIILYSRKNYELIVEHIARYRLQGNGAFAGELSIYWSRGVVSTIFNISLDLIVISLILLPQILAPSTRDLCHTSRSNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8P8</accession>
    <name>A0A8H5G8P8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8P8"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034209693" evidence="1">
        <location>
            <begin position="28"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="42709" checksum="0C5422FE5C1255E2" modified="2022-01-19" version="1">MTVTSRSLLSLLTLPLILTLTSTSTSAFETIENPFVGGDPENGWTYLPPVPTADLHLNWPITGTDSVMPVYQSAALDDSAITRAIIVPGGKPRDSWSYWITIKNILSYSAEIDPTINASTISIMSPVFLASVDVEAGAANATQLYWSKSGWFSGTYAEGPNADDKISSFQVLDDLVAHYADKERYPNLQEIIFAAHSAGSQFFQRYAALRIPTEDDSIIHYIPANPGSFVWLVEDRPAPNDTCADVDRYKYGLSSGFPGYSTGNVNEIGREGVVERYRSRNVHYAQGTADDGPGDTACEAVTQGSTHLERGENFVDMLNLNGGMPLNHTIDWVEGVSHQNDQMFNSTALRTRMFISATIPSTGLRPLRKREVKAKAAGRGFKQVRRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB42</accession>
    <name>A0A8H5GB42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB42"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="133" mass="14482" checksum="17342475BBE45701" modified="2022-01-19" version="1">MHDGRHTVIDLNNKWSTTILKELMEVSGGDAWQKWKRTAQSEEKPVVPGEKNETSSLSNDSGSNVTLLSYAAFRAANPIKPKEKTQAKATENDAAKEPVKPTQKKVKGGKVEAPFVEELKLDPTKTGAAAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB44</accession>
    <name>A0A8H5GB44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB44"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="13530" checksum="525345C43F96701D" modified="2022-01-19" version="1">MSEDFAALPGFYKLIFLHLEPISTMSPALLIWFWPGASWFHHGLIPSSSATPPSGFLDERTNLAYPKSSSGYMLLGLISSIVFRAIRDTLRSDPVAQERILGAALTALAIADVGLSRCSSSVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDP5</accession>
    <name>A0A8H5GDP5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDP5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5363027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="165" mass="17722" checksum="4BD7827AC2030757" modified="2022-01-19" version="1">MASWREVYKPDRGIGYGTEVPKLPDVWHASPGSKLAFPADAKQRHITTQSADKSQTQNYGLRSVFGVTVRWSPTDIAQGIDSRSGDIWSNAAPIVTSPRSPSTNPPKSKKSKILWGFAESGLLTFGGNLDVDWLGLVSSSWVVGSLGGTQGSCGKSWGLNMARDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH98</accession>
    <name>A0A8H5GH98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH98"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22935" checksum="E7DDA1B8FE01066F" modified="2022-01-19" version="1">MAMSVLEIYEFGKTFYSCANQLFTSARAPLDDNLWIRNDHRLGWLTHIRGFIGHPYSKYHLRAFQYFDAILCGCLHRLGPNASASASRPDRFIWRSDAPTPLRYKQQERFLFFLCCGLPTLASGGLPKYTLDCVGYGAGLFLGISVPDDMEWVEQLESFSDEEPQSDLVDESHRVMYKSEDVEEDDDDLYWESESDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHV1</accession>
    <name>A0A8H5GHV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHV1"/>
    <dbReference type="OrthoDB" id="621413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115862" checksum="5DAA1506DA76317F" modified="2022-01-19" version="1">MLSHAPNPSADYLRIGRMPSVSWWVARRAIHIRVRSSNRSDGAGSSDPLRHLWHLDFQTSLNTSSTPVLAARDGFSACRWGVCFVDVAEDFIEVTTTPLPPVCSLASPTPPAPTRSLAHTPPPAVDPDTAALTETKNKEDCINIAKDITDVLNVIKDIMERGKDIKQNEILIKNVGKLESDLSIIRDKLLKIRNRKTKFHLTSDAEIIKECKEKIKDYRDMFNIKASVNIWQNTGELLQGQEDIRGDIKEMMASIAKTHDQSTITYDDLERVTPTVSPVFFGRDKLVAEGANHLVNNEQAFLAILGAGGIGKTSIALHINNVPEVKTKYARASYFLPCEVLPDAKSLLQGLIQRLGIDVGQGESQHKKLEDYFRINSHSILLILDNFETPQNNDPLGIENLLGKLASFIQISMIVTMRGLNGPGYVEWKTLGSDDSIPPLTPESAKKVFSAISGKQELNDNIQAILKKLDYVPLAITLIAKRARTVPVESLLRMWEQGKTSILVQGKEEGRLTSVNYSIELSKRLLKPHEAELLAVISFLPDGVPDWVTNLPVMLSGWKQLDESISTLLETSLVYSQNGTIKVLAPIREYINEASMNIQRGITQLESFYMSWLKQLSGTRQDMQEQIQPHILNMTKIFNEQANSLTETLDVDALYILTGFTKFYPLTLDSLNNILNKWPELDERDKVELRFKRLHMLRWLSMWQEAEAEAKGMEHSMKNDLESHARVLRDLGEMYRLQSKDTEAAEMLTRAKDQFEQIGDQLGTAQCLQTLGRIYQVQSRYTEAVEVLTRANNQFEQIGDQLGATECLQTLGTIYRMQNKYNEATEMLSRAKNHFEKIGEQQGTAQCLQNLGDIYQFQNKYTEAADMLTTAKDHFEQIGDQLGAAQCLRSLGMIQDSQGNHTQAVAMLSMAKDQFEKIEHPLEVAYCMYNLGVFYRKRGLYEDAKSAFTNGIFKFQSLGSAYYTGWCLYEYGLVFMDEIQYSEARRKFEEAIDAFASHGESQNEVEMCNEQLAYLDHQLDQAQDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIA2</accession>
    <name>A0A8H5GIA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIA2"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034064336" description="Dienelactone hydrolase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="28598" checksum="5A77DC617E1C507A" modified="2022-01-19" version="1">MLFSTLASFLLSALVVNVQGAIVPQAPPSDHIFTTPSDVPTGRNVTIAGVNTYVNTPPRGTFDPKRAVVILMDVFGFGKTDNFTDTWANAGFATFMPDYLHGDPLPQDNSIPLDTWIVNHTEAITTPLILSVLHALKEQGVEQIGVAGYCFGGLYATRLTQNNTVSVATMAHPSLLVVPDDYEKVKAVSRVPVQINSAELDTGLTPALADEIDQVMVGYKPGYNHTAWAGVGHGFAVSANASDPVQVAAKEGAFKVMSSWISTHFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLD7</accession>
    <name>A0A8H5GLD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLD7"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="46817" checksum="DEC9DB3F6C46747D" modified="2022-01-19" version="1">MSWPWFGPIANDAASEMGWTLNQITWLGNIQAALYLPAALVIPHLYVWLGLRKLSYVGAILLIIASWVRYSGTVGTLTSNASFGLVFLGQAFASFAQPIYQVLGPKYSENWFDLKGRTTATMIVAMANPVGGAIGQLLSPLVGDTKTSILVLGIIGTAIAPFTFLIDTHPPTPPTFSASKKSPPFTHLLLDIVGKAPDSRMSSNRARTDFIIISLVFGTLVGATNTFSILTNQIMEPVGYDSGTSGLMGATLLLTGLVAAVITAPLFDRVLTHRLAFTSKLLVPILGAAWLSLIWAVTPNNTAALFVIMTIIGVSALTMLPIGLELGCDLTQNAEGSSSILWAMGNLMGFIFVLVENHLRAGPDAHPPNNMKQSLIFQGSFVMAIVLLIFFLEGKQTRKDLDEQHARSSGLNPEARRDVQSDDRMRGGEGTTDTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNJ9</accession>
    <name>A0A8H5GNJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPP34-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNJ9"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42186" checksum="6F8D524B5A6B5CB0" modified="2022-01-19" version="1">MSSFPSLSRRRTHTETDSSSTVIGDEEPRFRLVRTPTDSTSTSSMDSKIFSGPKILQDIVASKDGEKVPQLTIMEELLLLGINDKGHLSLRNEHLSSVLRCSILMELALRRRIALIPHQSRWRVPVSELVVEVIDDGLTSEPILDETLKMMKAVQTPLGAQAGVEKTSVKNWISLLSSEGWDVEVGTGYQLKQVRERLMKGLVDKGVLRSDTRNYLLFKTAAHPIADHTTKSDLIIRVARFLTASTFSGAALGEDSSNIRCPILRLVCLVCAAYTAGVLDHALSAANVGDEQHESALDRADQILVEFGCWPFGSPGPSSTPRLDRRKQAGRGSTPGAGDSRKFIGWLLQEVKSEIVQWSGGEDEDKDFGFELVAGVLEVFSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNY1</accession>
    <name>A0A8H5GNY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNY1"/>
    <dbReference type="OrthoDB" id="3139399at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22716" checksum="89BFFD58E6DCEFA9" modified="2022-01-19" version="1">MQSILSSSKTSHIQLKEAADRNIDLCKVEISRPLPAMLTPIKKLPVEVLGEIFSWDGRSGLWISQFEVQPAETEKEVDAPALAISHTCSLWRKIALSILRLWSTVVLDWVYNPPDVAALIGLYLDRSEPALLTLDVTIQGISFNSSFHGGAKNSCIWSILQSLLDLGQRWESTSFRLGPKISFHADSFLSSDHLYPNMKSFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP26</accession>
    <name>A0A8H5GP26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP26"/>
    <dbReference type="OrthoDB" id="3052556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1205">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="918" mass="103036" checksum="42C14C56118D8920" modified="2022-01-19" version="1">MSLLRGWRAKSERSNEALARNASSGPRKSDIDVPSKSKAVVDTLLSTLEIVADAVPIPAVKLVVQTAIRVIEMCQEVRTSLEEVDELRERIRSLSVVVVQAWSGKPAEDITDSLRRDIEQLQSDFVYIENKLKDISKQNTVRMFLFKTANEETVQKCLRKLDWSLSKFELSHQVQTATNMNTVLRIFNPEFRQESTARKPRPPSRSHIFYGRDELLNRLATRLVPASVGETGSKALLALLGPGGIGKTSAALAVMKHNVVQERYGGESNQFWVGCAKATSATLLLDILYDSLCIKKRTGQTLEDILAELESPSGKPDRQSYRLLLLDNFETPWNADEEQVERILRDLADIPRLSILITMRANQPPTDQEWEVEVLKPVDAEASAKIYTKIYPNTSEEQLCELLDAIGHLPLAITLLANYARTSQTTPVELLRDWQRDGPDILSMSDDDEDNVMHKSIKLSLDKPPMKKSTHAMKLLTLLALFPTSVSRVDLEKHWVPEGINQSKALHVLSKTALVELTESTAFVIPVIRSYILRHTPDRDFADTRLRIHRVCCSLIVDHGSSPGDPTYLADKQFLSSQEVHLQSILLDATSESSADVGLEILQALLTLSWHQCYTRPRFDLVKHTLSVSKRMKNAKYEAESLVCYAEMCRVLNQFDSAIKRVSLAHDLFIAMDDRVSAARCSIKLIEYNLFNTTSLEEHLSLAEQVRTECSADDPFGQALCDLWIGETYNKHSMPLEARAKLEQAKVKFEELGRRVELERCLDALACSYYSSYHLHPKLVPDSLTIALHLANQALELSIQCGRGEYQNHNLYNLTRILKESALYDEALERALEFLKLAKSLGDTAGVGDALREVGDILLRTGDYVGAQNALQKALVASEGMPASGFKDMEICDCRILLGRVETKLNFTTVESMDRATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQN0</accession>
    <name>A0A8H5GQN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_002600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQN0"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="178"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="396"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="837"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5369424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134771" checksum="2E129820C830559F" modified="2022-01-19" version="1">MAKRTHGDNDGSGVEDASPSSKRARTAGGNEGADGPSGSTQRAANKRSNATKKGKGKARQDASDDEEDADADEEDLDEEDEEEMRRQEKLIHAKLAARRKQVGGVAEHGIIESIEMHQFMCHKFLSFTFGPQINFIIGKWSIDASSARNIDCFTRYQATTGVCRHVFHTWIASNEFSGGKSAVLSAITIALGGKSNFTGRGNGLKSFIREGQNVSEITISLKNQGEEAFKPKEYGKSILITRRFTKDGSSTWKIRSHDGKKVISTKKDELAAICDHMNIQVDNPMNVLTQDAARQFLSASQPGEKYQFFLRGTQLSQLSEEYEICLENIHSTEKILEQKKSLLPELKERRKEAQLRFDEAKKARDQKERIEHLRKERAWALVNSKQKELEGRVLEQEKLLQKIAKIQEDKAKAEKDVGDATEEIKNTEEEMEAMGSQDELQHRHADLKEECRGLKAKIMNYKNDLGNINSQIREINAIIQGLDKEIAEQTQRLATDTQAKREEHQRQINEATAAVTRYENDRSQSDRRLEEIGGQIKETESTGMNKGRELESIQQRIGELQAQIQSLDKAEKDRYSPYAPNMMQILNAIKQTRWFGETPVGPLGVYIKVKDAQRWADLLSIQLGSILISFAVSDPKDMPTLKKLLNNFRYQDGRARIFIQERDIFDYSKGEPAPGLPTVLRAIDVTDPWVLRILINQRRIESMFLGNNRSDAERILGQVGAGQAWSADGFFVRRFPEGGGSSAPIERGGNNQNRVFLSGGDSNARKNHLKTQLAEMEAQYHPLNDEVQGLKRKFSDLKKEENNIINKGRQVDQGLQQAKRHLRQLQNEVNEEVPINIGALEDNKREQEEQKETILNQGAEVNSKKTQQEQVLKEKLEEVTRIKKQLNEYQEVRNGYTSKIEEAAERRLRAQATVKHRDDQLKTQQTLLDEKKAQVDNCEEEFKKWTEGATKISPERVQTNRKPEDIEKQMDSLTSALREREKRQGATVDELEDELNRTTALLDAAQKDWKKMNDLNKMLKDSLNKRLYRWQEFRRHIALRCKMVFKYNLSQRGYYGNIIFNHNAGKLELKVQTDDQNATQGARDKDPKALSGGEKSFSTICLLLALWESIGCPLRCLDEFDVFMDAVNRRIAMRMMIDTANQSDKKQYILITPQDMNNIHIGPTVRVHRMTDPERGQGVLAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQU7</accession>
    <name>A0A8H5GQU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQU7"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116939" checksum="8B2DD5BFEDD50030" modified="2022-01-19" version="1">MESINPVDNSSDVFSFNNDEELSKRLRFVKENGCGNWGSVWLCEPKTKEILSSDEAFDKTLKRHFAVKLVHRDKESKTSAARVKSLWNEMKIVRRFKSDPHPSIISFHSFLLTPSYALITMAYHPDLVTVQVSESHARVWFRYLLSAVEFLHKRGVVHNDIKPANILLSSKGIPILCDFGFAEAYDLNSTTAFHSKFAYGTPEASYLAPERARGIPHDTRKSDVWSLGVTFFEILVGRTPFEESDQEQCLSQDDLQKYWARTLRGKWVGTWKMSKGAERLLKRMLSPNADLRCTATEAIRDIYWMQDTSSSHRRSSSYTSSIIFEKDLSKLAEMSPPRVHSPRNTRLESPGSPPGLSPKSGDMHHRAVTKSKSQPKVNAARTQVQARKRVPVPNVVDLSPIKASPPTTPTTPMSPSPNNSTSIQGRIVSVHSSPNRRQPLGAIDTRGRGNVPPARLAAQPSIDKLAEKHKGRMLSDLVGPNPHARKGKGKENHVSQRVRDWERERERLREMSRLEELDKDTETEQEQETEPEVQEDKEDAKRTGLSISRNAVNLIETETPVSAPASSTHLPDLVFSPSDENVSRMAPRPSRSGFKHRVKSSIDKTMQRYKPSSMRGHNRRVSVEQSDMESRAEQTERESWEDEDVCRQAKTSLPVVRHALRNEQVAADNRLDRMSLWMRNVEQVVEDARQNFNTATSKESPLPPLPLPPSRSTSGANRSNRSSRLPRKILAASQIFDQSFSPEDQSMSSYVTSVYASSSNPAGSPKPEEDKAKAIDISAKLQTPPRRRATVSTRSPEPLVGPQVVINAPEDSSPSRRKEKSKSHADLLQLRIAPTSSIEPEARKEMSPATSPRLSAVVDRDLFVAPPKGSIRMDLSDDSRTSSPAIASKSLDELTSSPLRVDPYPPRNASGANPPVPDTPTQRRVENVYDRFLMATSGVKRVGKGYQSENVVPIHNTISHSNFSNIKQNHRAFYSVRKPMPPPVSSEDHQRQSVSVDELGMMTYHGAGTVSPGNKDEGKATITLVRRAFKAMVPGKTMNRRSRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRI1</accession>
    <name>A0A8H5GRI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRI1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="89" mass="9783" checksum="FFCB22965BDD6C25" modified="2022-01-19" version="1">MYSFMVSGVAIRVSRLLDIVDCGSSDRASDNRAYATTHPRKYRPTHSVVALFPDFPPTNCLWLSPQATQRNLVPHGTHLSGNELSVIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTT2</accession>
    <name>A0A8H5GTT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTT2"/>
    <dbReference type="OrthoDB" id="3243781at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="369" mass="42387" checksum="D2FC53D7275B1302" modified="2022-01-19" version="1">MGPSSYPNPSKTTGAAEIFFPITEANFRDMQHKLNAADWYEEYHDSSQLINRLKNAADDAAHLVVTRVEFIQRRASPRHEFLVVFYKDVNSPGCQGHVIIERTRLDYARDKIDREHITDIEPEDEDERGGPLSSGTPASSSGWTLDFSRIASSLSHSSSSSSESLSSSSRKQWADDTLRVSYTNNYVDFTKKGCKLLAELDFTNPSTARDTSTRDSHGVSVSMGEILVITSLVHRRAPRYQLRHSQCYYYARMIWHLINAIAGERVEIKQKKKRHFKLFYIVKREMQKKVEEDAPGLSAEFEKDWKQFKDAVECRRKELDHPRLVAEIQREQALKEREVASLERDRALREVARLESELAAIRSPQSQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUF7</accession>
    <name>A0A8H5GUF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUF7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="406" mass="44516" checksum="3A5DBED4E3899547" modified="2022-01-19" version="1">MNNPQIISRIAHHILHSESHTHSLTSINPSPWQTLASFRLTSQLISTIVEPILFETVEIALEGRVVGKRSCRLLDVFDVSSSSVLSARHEDHGARGEKRGSGWDPERAKRLCLLVKRIKIQSLNPGKAPTSTESLRRTSVAESESSETLKKRSSSSSSKDLEENEKNQAPTQIRARMARSLEDSLAIIKRFLDLKEVVWYIWSHSTLYQCYSSLLFSILSSHCSTSGPLSSFTLSILGSSSKSDLQGQLILPPEASSLKGLKVLRIQCPIPVPVSKPKLTIQTETQASASASSTSLSLSLATSAAVAVTSSGTNGTGGNTVAHTTSPVMSSSFYYRNWRTSGKDDRHPHPSPSQVCEMLVSYRQTLIQIHGYTQAQTQTLIDPILTIINSSPDLRVLQVDFRPPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVE4</accession>
    <name>A0A8H5GVE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVE4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="624" mass="70557" checksum="0E6493172BDAE64E" modified="2022-01-19" version="1">MFWSTPRIVDPIPLTTVVSTTEAHVLAFTLVLIYVGSLYLLRSGQLQHYPREPPSHLPSLSIFDGPRRRRPLPDGDKPKPKRAPRPPNALPTYDLSLSADERIFCGLVRGAIQRCKEEEEQEKKEQEKKREDDQYCASWRQHWEQREPTSKDSPVYNRTRILLACFACSQSVLLVWAVVFVRVYRWGFAPPLATVTINGHVQDDVRTTVPGWDKTAVWSSMRYMGALLGFTMPSFGMGLKSLLVSSLPFFFLFLGPITSRLLSALSTFTTWFIWTLSAPDEQINASFRSIGNTLADKFTFVSLRDFLAAPVTEEIVFRACIIAVYHLTTVYTPISTSARILSEREPPVIFWGDVWATQLYTDVDQVYDFITERTHVSYDDKSMSGALGLTTTQIILFSAIQFALAHVHHLYDLYHQYYLHHKKSGEWHEDDIPRVKRALKLALFKATISMMFSAGAYGTMYAWLFLCGTSALAFVPFAASPLELEFPRTGYNWTMQAAYDFVAHRGSERVLEYARDDFTLKFNLLTTGIPSLLAPVTAHILVSVLRSPDFFGGFEGFSVDEFKKDVRRGVEAARVLGRAVYGLGIGTRDEDVTQHAERIGRGLVMAGYVVGGLVFLWTVWVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVV5</accession>
    <name>A0A8H5GVV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVV5"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="212" mass="23821" checksum="D19A41916EE8EF5A" modified="2022-01-19" version="1">MSNLELLQIRQLAGHSESRYSGRSANALCRRCNDGLFLDRSRQHSTCSDCSVQEDIEKEMVDAGLIPPPQPALSTLPLKTENPRDSTVLISLNSRSGKNTAVDEEEEAIRTRLEAIGLHVGANFAERLCRDRSLFTETLDVIKFVCKDLWAACWDRQVDNLRTNHRLTKSIQGIYVSQDNAFKTITRLSSWEGRANATRKAKLGSNSVHDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWD3</accession>
    <name>A0A8H5GWD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWD3"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="41365" checksum="201DA14DA16E2B5E" modified="2022-01-19" version="1">MEVVNENDSDAESTVSDTDSDISLESDEEDDDACEAEYLQGPKPMNKETLSQNMFPFLHGHPLADTHAMKVGSNAKRLVPNFIGGTLPRADKGNREYYCTVMLTLFKPWRNGKILKHEDQSWDDAFTNFQFTAQQKQVLKNFQVRYECLDSRDDYNAQRKTMSNNAVDADIIEYEPEYDDGIDSELLEISDECGPFERHRQEDMNEMTGILVGMGWTDNLHDRKSLIPQECQPEVTRSAHSWKLQINKMRQDILDKRHKSSANQDTANKFKNRFPNQVEILDKTAFETKTRQGQTQNLIDTIANEYKFHDNPEQNRAFRIIANHAASPCPEQLKMYIGGMGGTGKSTVLRALRKFFCRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX83</accession>
    <name>A0A8H5GX83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX83"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_eL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047868">
        <property type="entry name" value="Ribosomal_L34e_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12395" checksum="30CFFBEBA36B63BE" modified="2022-01-19" version="1">MAQRVTLRKRTPYNTTSNRRRVVKTPGGRLVVHHLKKPASQPKCGDCGIGLPGVPALRPRQYATISKRQKSVNRAYGGSRCATCVKSRVLRAFLVEEAKIVKKVIKSQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H072</accession>
    <name>A0A8H5H072_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H072"/>
    <dbReference type="OrthoDB" id="3176940at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="142"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="409" mass="46935" checksum="B6A619AE28F5A01D" modified="2022-01-19" version="1">MFKIKAEPIDDSTVLAAVSLPSTSSRTSLEFDDGAHSLEGSEDVDHDSESPSGSTNRAPKRRRIELQGVFVRVFDQILRSERRKRELKRKFKKLKNPKAKMTKIEEKMMLSDEAFHSRLRLEGIQLDPMPINLIKTILDIPVRREFMRDRYGGSAISCFPGIAQERVDQHGYSDFMYLNMKYHPNAPQVPGAPGLFYNAGETNEDWTDPSWGKKMRVFTRLESGVWLKMGIYDLFYSKPLSREEWSRDDMATMRTAWAKKLFEKDWGRRMRCSIKLRKSLKREPTPEELKEAMATKDDFKAVTADDIGRAFMRGEEVVSVWAMKCVDYDVDFQKTIVEAFGQWTKPAPKKSAKSKGNPGPRPKATKVSTSSSSKTSKKRKAQEMEEENSDDDEYDPVYVPRGTRSRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1N4</accession>
    <name>A0A8H5H1N4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1N4"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38790" checksum="6A3A0C894CA6489C" modified="2022-01-19" version="1">MKYYSHEDFVREQTTPMAPVVTADLSGKTVIVTGANTGIGLEASKHFARMNPGRLVIVCRNETKGQVAATEIKNETNFDCVELWIMDQGDFSSIKAFADRAEKELSRIDYLVENAAIYNAGKYILTTNGWEQELQVNHLGPTLLSFLLLPKMITTAKTHNTHPRLVSVSSNVHYWASIEKELIDAPNPLEICSSKEYCTPSVMEKRYQSTKLLNLLAVRALHARLPQTFPTITIVAVNPGLCDSPLYRSIPEESKNYWADRMKLAYTSEEGSRQVIYGALGGADTEEEEQSMRGGYISLSELREVSDWILSEDGSRAEDKFWNETVKVLGEVDDRVHKVVSGYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LH77</accession>
    <name>A0A8H5LH77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LH77"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034104010" description="Alpha/beta-hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="441"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="630"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="946"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5357350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1075" mass="115240" checksum="B0533952169379DD" modified="2022-01-19" version="1">MTPLSSVSLLFGFVSLSVVLAQGTSGFDWNSIEPSTNFTWVDCFSGFQCARFQAPLDYSNPDNGQSAAIAVVKLAAQAPASEYGGPIFTNPGGPGGSGVSFVLEDGQFIQSIVGAQFDIIGFDPRGVNNTTPQISFFNTDVERLAFLLDERADLNSTPEALPESWARYQVAGQLAQSRDNGSLNFVTTADVARDMLGMSEALGQENLQYWGVSYGTFLGSVFATMFPDRIKRLVIDGVLDMDAWLALDLGGSVNDTDKTMQWFFDGCHAAGPENCAFYASSPAKIEAALDDIYDSLRSQPLPVFLNSDLYGVLTYDTLRGIIMVALYTPPLFPVLAQGLAEVQAGNATTFFKLISIFGEGSTEALTAIECGDSDPFNADASQLREYMSRINSTFAGMGGMPLMNRCTFIPSIASKVEGIVTSVQALSCTDAKTLKGPAGAANTSHPLLVIGNTADPVTPLAGAKKTSLSFPGSVLLTQDSPGHTSMNTISTCTHQHIAAYFTNGTLPEEGTVCSLDAPLFPTSANATVSESPRSFMELHKRILEGYRLKFVSLLFGFVSLSVVLAQGTSGFDWNSIEPSTNFTWVDCFSGFQCARFKAPLDYSNPDNDQSAAIAVVKLAAQAPASEYGGPIFTNPGGPGGSGVNFILESGQFIQSIVGAQFDIIGFDPRGVNNTTPQTSFFNTDAERLAFFLDERADLNSTPEALPESWARYQVAGQLAQSRDNGSLNFVTTADVARDMLGMSEALGQENLQYWGFSYGTFLGSVFATMFPNRIKRLLIDGVLDMDAWLALDLGGMVNDTDKTMQWFFDGCHAAGPENCAFYASSPAKIEAALEDIYDSLRSQPLPVFFNSDLYDVFTYDTLRSIILMALYTPPLFPHLAQGLAEVQAGNATTLFKFLSTVSGEGSPEVLAAIECGDSDPFNANASQLREYMSRINSTFAGMLGMPLMNRCAGWKIHPEHRFKGPVGAANTSYPLLVIGNTADPATPFAGAKKTSLSFPGSVLLTQDSPGHASISTESNCTSQHIAAYFANGTLPEEGIVCSLDAPLFPTSANTTVSDSPRSFMGLHKRIVMPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LH87</accession>
    <name>A0A8H5LH87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_005926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LH87"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034229107" description="L-type lectin-like domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="41"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5357380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="39806" checksum="D927FFFA46779F02" modified="2022-01-19" version="1">MVSRFSSHLWLSLWAFVVFLGYAQAADEVKTKLGNATIDRTVQLRTHSIFAPYIDQDLQNRWWDFGADAYINTNKYIRLTRNKPSEMGWLWSRLPLTASNWVVEVEFKVSGESSHLFGDGMVIWLAKDRAKPGPVMGSVDNFNGLGVFLDTYANTRHPYAFPRIYAILGNGQTSYNHDSDGEEQQLGACSANYRRTNVATKLKITYVKDTFLDVKVQYKAWDDWSDCFFVEGISLPSSPYLGFSAQTGDVSDNHDIIAISTYSAITKSLSKDSQSSSKSRVSVPGISSSSWSGFFFKLFLLIGVCVGGYYGWNEYKRRTARGGFGGGGYQRVLVGMEDLEGFIRIRRGSEVGAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHC5</accession>
    <name>A0A8H5LHC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHC5"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="137" mass="15297" checksum="F4DD5533CFC8D9E1" modified="2022-01-19" version="1">MTVAVTKATVEPVCYLPGLAERFRISETILRRSLFEETGGMYPEIITQPNIKNLPSPNLESTAQDVQVDMAKDEKKGVGVVVYFQKEGKALGEVTKYLEYNLRKRGEGSADRYFASTEIIAGVKDMSPHARRLTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLN5</accession>
    <name>A0A8H5LLN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLN5"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="263" mass="29481" checksum="4AF84462E43C5A6B" modified="2022-01-19" version="1">MSALLQDVLRSHSADSKTIERKLKSLNVQTRNHTTNANSNNGDDSDDSDELVNVVSIPGTPSRTRPSSPTRTGGAASRPIRGPLHISSQPTRDPLKLLPTEISQKIFSRLSIRDLAKCALVSKKWSRSQTINYVWFQVYRKDNFRDDSLPPGKWTKRESKQNWRISHLKSVSERSPTTTGTNGYTPSRGSGYTSPSTASGYQTPREIREERWRQEAEATSSPGKVEMRAMYKELGGRKSKAKTKLGSTGVRDKGGWAEERDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LM60</accession>
    <name>A0A8H5LM60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LM60"/>
    <dbReference type="OrthoDB" id="2683906at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="526" mass="54492" checksum="961C47FB8B7A0065" modified="2022-01-19" version="1">MSGSSTSSSSTSSLLSSVSSSITSSATGTPTDLGITSSSGFLTVPPINTQPPNSGGGRGGGGGGNGGDNGGPNLASSASLYLYTFLATLLLLLSVSAAIVIRSLLLRRRHRRLVEEAIRNGTYVPGMFGNVGGPWGGGGGWGGGLGGRSGNKVDLAMKPKLWEAYLGVGGSAQKTVKAQTQTQTKTRDEKLNEKAGDSGPGIGSSRGGGGYGAGSGGGYDPYTYNYSNYNKDEFMDWEGIVPFSASLTFPLPSSFPSSSTSAINTNGGPATANDSRNGSTTSVNRNGNNSRSLTQRIRGGLVNAPRTVWGLISTQQQYRRRDDEFDMDMDMEHGNATMPNTPITGMTTPTGARADATNTNSNTTTSPPPSARPLLTRFLRSPTSAVGNGLNANANANTNMNTNANANTNANTTTSSPNTSNNKTSPGQNQNSKSKHQPLPSSPTTVPVNVSVSVLIAMPSRVPLVDKLCKPRPRTGAGAGVDEDEEELPHLEVGICEVVVPPEVDVEKEKEEKRGVEGKGKESVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPF6</accession>
    <name>A0A8H5LPF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_009301</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPF6"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="66"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="582"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5364747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="781" mass="84170" checksum="A051554C1ABEB4CB" modified="2022-01-19" version="1">MLNLSQRTANVLRRLAAGMATVAPRIGDTKVPMSLLEKSSYINYQRIEDNLAVVRDRLKRPLTLSEKIVYGHLDDPHGQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGMDTTAVPTTVHCDHLIEAQIGGVKDLQRAIDINREVYDFLATATAKYGMGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMVACGVGGADAVDVMAGIPWELKCPKVIGVNLTGKISGWTTPKDVILKVAGILTVKGGTGAIVEYRGPGVESLSCTGMATICNMGAEIGATTSLFPFNTRMVDYLNATKRGDIAKYAQQFAPNLQADQGAEYDQNIEINLSELEPHINGPFTPDLATPLSKFAEEVKKNNWPEELKVALIGSCTNSSYEDMSRSASIAKEASAHGLDVKSKFTITPGSEQVRATIERDGQIAAFENVGGLVLANACGPCIGQWDRQDVKKGEVNSIITSYNRNFTGRNDANPATHAFVASPDIVTAMAFGGKLTFNPMTDELIGSDGKPFRFTEPNGNELPPKGYDPGQDTFQPPPADRASVNVAVNPSSDRLQLLKPFAPWDGKTPSDLPVLIKVKGKCTTDHISAGGPWLKYRGHLENISQNCLIGAINAENGEANKVKNQFTGEYGGVPQTAASYRDQGIKWVVIGDHNYGEGSSREHAALEPRFLGGLAIITKSFARIHETNLKKQGMLALTFVNPDDYDKVQPSDKVDILGLESFAPGKNLTLVLKHADGSKDEVPLAHSFNQGQIEWFKAGSALNLMAAKAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPN4</accession>
    <name>A0A8H5LPN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">D9758_008131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPN4"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5364972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="180" mass="20891" checksum="3433ACBC903F1692" modified="2022-01-19" version="1">MPLSPPINFPKWLEENKSLLQPPVNNFCLYRGGDFIVMAVGGPNERNDYHINETEMNPDIKEWFYQHKGGMLLRTVDEGKFRDIRIEEGEMFLLPANTPHNPVRFANTIGIVMERERPAESQDRLRWYCPSSSHETPTVIYEETFHVTDLGTQLKPVIERWQKNEDLRKCKSCGTVAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQU4</accession>
    <name>A0A8H5LQU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQU4"/>
    <dbReference type="OrthoDB" id="3262412at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="978" mass="111549" checksum="9C88D8D54E554012" modified="2022-01-19" version="1">MDSTAASQDSTEDLQWCTGCSMRKPLSLFKKGASTAKTCAGCRGRPSQVKKKPKITSNSTVDDNDPADSLLDLPLVSFSDFIRTIESVQGIHSFAAQVSLKEEQLGNTSRAKADHIASSVWNATGLRFIYHKTYSHRNTPSANVVYHCAQQAKRQHKSTASARDKGQMHTFDCKGWLRITVFDDAKSALVRLQHEDDHILYDGSDVPSNVKDYVEKNFKMSTNALWSEILQSYPNPLFKRRSIASIAADVRRSQWCRDPDELKSARIILEESKAHSLWSICEANLPTVDGYSGIAFSLPDVLQRFGGTVREVSLDSAWNTNGSRYELYALLGEVYGSGCPLGFLLLQSPQKGDAGVKEDYILCFLEHFKTKYALDPLFTLSDKDLSEINAFLKAFPSSKHQLCFWHCLRAVKQRLSILRRPPKFYDVTKTRNEFGDEIDKNFVPVGQVNEADRVDFPMVEQALPRVTVRLQGVLQNTAPPKPRLVIRINGLTRDINPDSENPTVESGYESAEIQDNDEEDGYCQDPDYSALFDFNNTDDEYGPDWMFDESEKPSKDPLYVFCPAPHRKQLLHLFTRHFCQHPLFPERLEEDGWTADQIRRNAVIEMYRFCYQRGLREVWGYMWTSWYSPKMWKLWARSTQANLLSRLRTTMNVENFWKQLKHDNLHHILHPRLDQLVWILINEVVPTYGVRIQELKMTMRLGTSRSLSPFQKSFKKDWNTLSKQKIPSPNKYTTHIHTWTCNCGQQKYNAHCLCKHLVQAVSAPLPIFFQQVIQRRVHPFYRHPMLVPKGHEYGQYTKVEDGSITEGDDQDWTGDVSQLSGGAWREIVSDASLGKRRHSSAFSNEASTRPPSPEYNVPADVELTSDAFSGRSSSPIDYDGSDNEQELEKYVGSAEDMIQNLRRAADLIEAQLPYRNFPWLKALNDGKLGKEAHHFVADIAGFEDSHGVRPTTWASSSSKAAKRVERNTLGYQVQRMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRA0</accession>
    <name>A0A8H5LRA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRA0"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14193" checksum="FBA6A4719B605C81" modified="2022-01-19" version="1">MASAQKKKTGGKTRSALQDVVTREYTIHLHKRVHGRSFKKRAPWAVKSVLEFARKAMGTSDVRIDPKLNQALWAQGIKTVPHRLRVKLERKRSDDENAKEKLFTYASHVPVTSFKGLQTVVVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRW6</accession>
    <name>A0A8H5LRW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_003993</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRW6"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="437"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5367131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="542" mass="59648" checksum="2F2B91B4C884984A" modified="2022-01-19" version="1">MRADTVARDGGCIMIISAEDDYVSTPDSLQPPSNCLEFFFAMWRPATRQITGTNDVPLGQRRRFGPAPAEESAPPQLAQPSPSAYPKPQDHSLDSPGKRGREESPVNGDPKVDSNAPRKRRSRWGEGKTEIPGLPTAISAAGVSQAQLDNYAIHLRLEEINRKLRLNDYVPPERERSPSPPPTYDAHGRRTNTREVRYRKKLEDERIRLVDRAMKNDPNFRPPVEYHQQKRSQRPSDKVYIPVKEFPEINFFGLLVGPRGNSLKKMERESGAKISIRGKGSVKEGKARQDQYADDAEEDLHCLVLADSEEKVAACVKMINRVIETAASTPEGQNDHKRNQLRELAALNGTLRDDENQICQNCGGVGHRKYDCPEQRNFTANIICRVCGSAGHMARDCTVNKDPNAPPPPPTPHMSRGGFDSEYASLMAELGEPTAAGNAIDLNKPSWAAGPSGGHDITGGGTNIPPWRRPENWQTNNIPQNQNQGYRPPQGGFSQSSGGGGGGGYGGWGGGYSQQGGYPQQSQDYANYASYYQGQYAQQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTP1</accession>
    <name>A0A8H5LTP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTP1"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="491" mass="54443" checksum="30D1C3151EA7A9E9" modified="2022-01-19" version="1">MATQDDRETLRLLVQHVSRGFYEAKFTIILDQLARHPVLKDDDLAGRMGLQPKELNKIIAVLANDCLVKVYRQNELKEGAQRAVGKQYYYIDYAHFCNVVKWRIAKMRHKIDSTLRNELDNKGYICTQCKTSYSPLDVDKLMDFSLGTLVCEICRGEVIDNENAESVQGSKDRMSRFNHQMRFIRAGLQKSEAMVFPPFDVATWIKTNLTGSDDKSSSQAGAGLKIAGSDGKQTEDDGIGVVIASDKDEATRKMERDAEAEIKRQQNALPAWHLKSTITGDLTALGVKENARAEAAAANGVQSPDDLLRGLGVVGAKPLQQRAMPMQVERDVKPVINHEAEYYDQYYASLAASAAASAQATPSGLSAPGSSDFDEFGEEEEERKPSIEYLNSLNDYRKRSRSQEDEGTVGRNKIAKTEDVAENGHTLHGSLDHRGIPAQSDGVADGSGDDPIVYVNGNAKPFSAVTEEDHELMTPEEYTAFFEVMQAREEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUK7</accession>
    <name>A0A8H5LUK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUK7"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="22217" checksum="664504FF7542B825" modified="2022-01-19" version="1">MTDLTFCYLHMTKRDLQVLDLYETKDYVKTKLSDDEIDIPFHMIPPNPEDSDNLPSNTHPSYPYGNPMSIKHPASRPRPRYDPIARTSLHTELGYDGGGLNGSLRWKELALSELLPVDELKEEAQKAMEARQMASGAGNNNNPQAGQAQEGLGQGDRTIDEEEEEEEEEGSEEDENDENELDEDDEEEDEDESEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVZ2</accession>
    <name>A0A8H5LVZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVZ2"/>
    <dbReference type="OrthoDB" id="3220023at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111151" checksum="B18DC0C3BB4B32CC" modified="2022-01-19" version="1">MATSLDMSSVPDAATGSSTKLPPSKKQRKSNNKRTNNLINSSSDPISSLPGFRKLPVELLAEILLYTKSPRDVLAVARCSKYHCDTLMNAGNQYIWKYTRQHCKPAPLPDPPKRFTEAAYAAFLFDEGVCEECKTPVKEMMDSFGLRLRLSRMQNQVHVVSIPSSLSHVNPPRSETNNSFLPSGSSTILMHNPAVMESHQTFIETLPMLEASNCLTGSGLSVKHYPEVSPVYRSSQWVSALQDYLEASRTPETYQKYVEECSIKAEWNIDFLKFCANLYRWKVQYQKAYQDNKQFNLQFATNLALKHGQTQLDFLSTPTYGVIHRNRLKILEHMREEDYTNHKEVIDSELLSLRERRTRQANAKTHQITRDAIEKHYNRLRATKQLLPLPTLETFRQLPIMRQLQTSPRPHLSTGATATGTPGNSQSTSPSLEATLDNSLKSPIITSLLTSQLAEWRESVKSSLAQTLGFPKDWKSADPRKLHPVDRVTARFICGGVGGCGRISMAFKEDECLDFVGVCGHVCSRPSSGPGSEGKKEKKKEKPFNGKRFVKDEKAINAMNKVLNACGISDDDPLSLNELENIKFRILCTSCDARIVMDVNSVIGHSHRHSDMQLVLVSSAEAEVILKPWPGMPSIASIESQRGLTVKFLGSTSGSKDALALKMKKGYGCRHCLQGPHQLGEQGKERDAVASTSTTTAGAGAGTWIGTTASATASATTADTDVDTSAPAAQAQSQVQKSKKPQTQIPTPAGFTFDGLRCHLKEKHKVESVRDEDYFYSDQLKKACEENEARAKKRREKEKEKKQGCGTRLTYYITNLYEDNEHSHMMRPRPLHLSNFKTKDKPKMQFLSILRTLSAFLFFAAVYAAPTPLRVVNKLQFGGAGGVGAGGTGSAITTTEVHARQAAAQAAGTVTCTNKAQQLSSHDCNVALLSLGPGGIAGAIQFLRPNTASVTATSGGCTVSAATTDGSIIDVSKGRLEHGGVKGFDNLLDECGATPGTVLVQGGATGGGNLLVTISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWH1</accession>
    <name>A0A8H5LWH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWH1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="152" mass="16907" checksum="24C29FED38762748" modified="2022-01-19" version="1">MNGYNDQQPPSRRFRALTLPHLTSLRLTIPEYDVCDGEDAVSLLGFSSFLERSECNISVLGLVGLQIDDGKTIYLVELLPLVMDLTVQKHPKRRGRKYSTISSSSSPAQDSPFRIRLPKSFPPSSLTKAKFSVPLSVRRGHSPLHATISLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX70</accession>
    <name>A0A8H5LX70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX70"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="37148" checksum="12C69076761AA517" modified="2022-01-19" version="1">MSKILPVLIFPVLSAVGLTFVWYHAFASGFISKTFFEECANLRNPNRLPSSGYPFVDQGLCLLISLFSALFDQYTYPFLLWLMVALAPIVSFMALEASRVDSGAPLMVRNPTLTGITIQTMSFAFTTPLYWLSIITSGRANMRPSFTSTVSKEHAQAIFLAVLLGLVAPTFYMMHFQTPSTILAWQPFPVFVAIVHGLCIAFTGSSSKSGYSYIRALYILNFLANAYVHLSILLPNINNLQSLEGLFVPSTSLIDLAEPASAHALHLLQWDTYIGIGSTVFATLWFARSAGQFLGLLLWNLVAVPIFGPGAAFAGAALWRESCLHSDVVPRNKKRGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXB2</accession>
    <name>A0A8H5LXB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXB2"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="264" mass="29136" checksum="E2C9FB09BC3123DD" modified="2022-01-19" version="1">MFAARRLHRRIGAKPLLLAAAGITLSTEKEKLPIYPAPPSEVVVQEVPSELEKQIGIVRRQLTQTYTEAHAHVQGLVSKWIGVEHAVEHRVKSIISPEEPLTPGILYVGVATLSGSIIGRNRMLPIRLLLPPTFLILSMNHFLPKTTTNLSEYLSSVEETYFPTLAEKHATANAHSRMTWERLKEATASGRASLHSGTETVVGKIQDSTGLKLRETLGFGQEVSKKAEDRVLEAVKVGQQKAEEVKTAADTKIEEVKEEVKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXN8</accession>
    <name>A0A8H5LXN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXN8"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5373164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="361" mass="39141" checksum="AD5B23DB67F803E7" modified="2022-01-19" version="1">MDNDDASKPTPTEPAAMASNKPRPKLDLSSEIKPGERRRGKTMFGLVLGTLNKAKIEDKERNASEAAKKRQMIEQRLQIKLRKETDSVRRAEEAKKDKTAANRKEEELQLKDSIYKLRRTRLSLLANFLCTSDKIPEEDSDPTPTSADPLAPPPRSHPPPLYYLPAILTPAQEAFIKKRKEAVTEAAEKEWQYFREERTTGIEEIHQLRQRVAEEEAKKKARGGGDDDAEMDVEGDNANHGRDQDNSADQGTSHSHTNGTNGRSHSAENKEDKEGDSGKPAEPEAESMSMDVDESAAPAPAAGADAGTGAAGTELATGTGEGSTTTTEKDGTPAAASASAPTSEKKDTGAMQADDDEAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY07</accession>
    <name>A0A8H5LY07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">D9758_000907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY07"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5373536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="42745" checksum="F539CD59A8949ECF" modified="2022-01-19" version="1">MSIDLEWNSLDSSLSDKLVDILNRQLSQTSRPSFIGPVEVISLNFGSTSPDVELVDLRDIYRDFLEDDEDNSDQEPAKVTENAEEDDDGFEWVSRRAAKREEGLAFQQYPHLRYGRGGPMDMFASTPSLNTHLEPYNPTHSLVDYRPLHMSWPNMPMYASSMSQIPMSAPANRRSFETGGDPASPLHNSNDDIGQGSAPQNAHSEQQPPDPPPNNHPNLQLHFHVNWNSDLRITLTTSLLINYPSPMFMSLPIKLSVTGLIFTGEIAVAYEGERGRVHLCILDDLDPYGPAADRPKRDASHTPPELDLDDESPTMTRHSKPLPIGKRLLPSIFIESEIGQTDKHVLKNVTRVERFIQDVIRKTIEEELIFPNFHTLVMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY14</accession>
    <name>A0A8H5LY14_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY14"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF41">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="310"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59407" checksum="AED683DF404425D1" modified="2022-01-19" version="1">MQPYDELVFYHFNDVYHVCQPTVLSRFSYIFNQKHKADDSYLTIFSGDAFGPSLESNLLKGEHIIPVLNHLKIDVACYGNHDFDFGEDRLKELSGSCNFPWVLSNTFHQDSKHSLLASAKEYIVLTLKGYRIGFFGLAGTDWPSNCQHLPHNTVIEDPVQAASRISKTLRQDENVDLVVAITHMRLEEDILISEACRDVNLILGGHDHDIVVHGRDLVVVNDDAKGDIRIVKSGTDFRSYSVVKVPIRKVEGTVELGSIRVHHERDISSYEAHPEDPEIPKLIADTEARVATVSNIPLFKTACSLDGRSTRIRNYETNLGNLLADAVRAYYNTDIAFVNSGSVRCDRIIPEGVLTVRDVVDILPFDNAFVVQKVPGHVLLEALENSVSDSRTDGRFLQVSGLSFTADLNKPEGSRILDAFLNNDACTDGSRTAITPQSQEKFTVTMVSFIAEGFDGYTCFSSSSEVETLVGVEGALTDNGIMLEILRGDEEVEMSGEEDVQRARARRVILVPGQDEASGLPVVRPRVEDRILYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZK9</accession>
    <name>A0A8H5LZK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZK9"/>
    <dbReference type="OrthoDB" id="3252971at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5375204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="398" mass="45503" checksum="7C8394AEA6308E9B" modified="2022-01-19" version="1">MAISEMHFKKSYTVEELAPLIRSAWIKAHFVAPWIAVRTSSQPNAPHNSYMFMYKRSSGPEKTEAWAGETIVWRKETKTLNEWEVEMKDRHWKPCAGQFGLEMRLAKWPMGSGQGWFLISWSSPRTGSHWTSDGRDLFPVAERMFRILHDKMDGMDTTPCASLRWREEVNCPTTTRTIPIPNARCRDAQDSLSLVPETKSSDLLYKRYYISMTSAINSIRTVTVNIADMRTSISPFSAKRLGDCGTGGLVNIGFPTKHDTDFIRQCLYIGNDRNVHKSLSPSSFWEDVATDTQAALKEGYLSTVEQMALKIDGFVMSAPGIMSSSLGDVEKLRWFTKYRPLYADKYPDKFEIRNAYSQFCCESRIEVVGDSTSQELWNMFLELVREGFQDIVMFKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B027</accession>
    <name>A0A8H5B027_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000527">
        <property type="protein sequence ID" value="KAF5313538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B027"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5313538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42093" checksum="01AF144B7B140F89" modified="2022-01-19" version="1">MPLWKANNNKSMIPPVEAPSSGGSGRFGGGGGLPSGPASSRAASNKSSGSTYVPSRDGDLYQNNNYYNYSRYGDEDQGQDQGGYGGGGYQDKYSRSRGVGDVYTRGGTDTTVEQDRNELFSGYNPNSSGRAGGSGRFFDGPPGPGAGRPEPKEGEETEEDVEGIKTQMRFVKNESVNSTRNALRMAREAEETARGTLGRLGDQSERLANTEMHLDMAKLHAAQASDKTDELKKLNRSIFRPAITFNKDGKRRAQEQKIQSRYDEQKSEREKAMLQVRETQDRVGRAQGYARGGYGGEDDNDLMGGGGEEGLSGRRFKTQEQRQASRAATLVIDSMLLLQTMSSKMRLMIIWTRLAECKDDGIAGKVDNVDNKLFNVTSRQKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7Y0</accession>
    <name>A0A8H5B7Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000463">
        <property type="protein sequence ID" value="KAF5317881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7Y0"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5317881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="399" mass="39494" checksum="97EFA251874BDF22" modified="2022-01-19" version="1">MYSLTNDLTPGKEKPSWPLSSFGAAKHETNLVSGLDQTFEELRVRAVGAMKEGGNALNQYIQYEATQIANADQQYNMCNARSNIQAAYDQAVKQSQVVTTSAFGGGGGGTTSAFGQPSNTTNTTSVFGHSSNPTNSTSVFGQPSNSNPNPTSAFGGTGAITTMSSVFGKPSFGRPAFGQTGFGGTSTTSTNTNNTTTPTPTSAFGTPSATSTSAFGAPSNTTTTSAFGKPSFGQSSTLGNTTSSSSSGHLDLQVQQVLLVLVLASVLGTGTGSGGGAFSAFAGKPSLFGASAAPGGNTGSTTSVFGQPAAAGGGKSVFGQPASAVGGGGTTSVFGQPAGAGSGTTSVFGQPADAGSGTTNVFDQPATGSTTSVFGQPASSSNSNTNALTPEVRFYRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTL0</accession>
    <name>A0A8H5BTL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000352">
        <property type="protein sequence ID" value="KAF5329001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTL0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5329001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="186" mass="19851" checksum="F205933E70236FA3" modified="2022-01-19" version="1">MRTPKTPMCRIQHFPQHPTHEGYHPAPAVAMSQTFLAESQVTTQTRSAPQYALPVHQFHIASPDMTEAPMSPPLPPTPLNPSRLYTTIPLPPQVNVDVSVIPFLQSGSGSGLDIDLQDDDTVAKVPRRASDESTDTLNDGDTPRATLANYGVSVRNGVRVCDGMGCVGDHSGVVEVTGANTNASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0L2</accession>
    <name>A0A8H5C0L2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_015955</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000299">
        <property type="protein sequence ID" value="KAF5332929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0L2"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="18">
        <location>
            <begin position="117"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="174"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="607"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="744"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="619"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="793"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5332929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="862" mass="97451" checksum="B8A92027537AEE0A" modified="2022-01-19" version="1">MSTTASTHAVKDEPDTPPPVKTEDVDMKPALDTSRSGTTTPALPLPALSNDVKKEDPDRKSSTPPVASSSNSRKPIKAPPQLIGDLPIARDEAMSTFKEMLDNWYQFKSLGRSREFMESMTCDCVFDPSSDHPEVACGHNSECINRLTQVECLPDDCRCRDYCQNQRFQKKEYANIQVVKTEMKGFGLRAEVDIPKDTFIYEYVGDVVNNTQFKKRMRDYANEGIQHFYFMMLQKDEFIDATKNGGIGRFANHSCNPNCYVAKWTIGKFVRMGIFSKRHIQKDEELTFNYNVDRYGHQAQTCYCGEPNCVGYIGGKTQTDISTMDELYLDALGITDEADLMELKGTKKKKGKKIDDPDFMPQMKPVVEKEVPKVIQAMYQTSSKKVLSKLLTRLKITEDPAPLRQAIRLRGYSCMKVILEDNADEPELVILALECMTKWPSISRNKIEDSQVTTPVKQFTESENEQVKGWATKLHDQWQTLEIAYRIPKRQWVAGAPEEEETVLIMPSEASVSTWQSSTFENTYTRPEFNPKKRPRVNTEDKALDPQDKPVWDNKRGEWITPRELEEERKKMEKFEEARELAEKRKLKQAAAVEAIIAAAAKEREAAQVAALAEAAAAAEKEKKRLEAEEKRKASGGSKRRDKEKEKPREKKKKTVPDEEKEKYKEKKLLKLISPVVVNVLSKHKEIREHEKFKKFAKELSEKVAEREKKSSAYRHGKLDQLSEEKLKKIKAYAKEYCTKLLAKMHGKSRRPSSSTNGHVRASSSTLVDTPVSAADTPNSGDLPTRVAGIDLQENEVDMDMDQDVEMDVDSDSDSDADGDGDGDGDGEPDAGAGPSGFREHDDDNDAQTHFSPKTPPLPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2I9</accession>
    <name>A0A8H5C2I9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2I9"/>
    <dbReference type="OrthoDB" id="3221808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17216" checksum="CA284BBAEA264356" modified="2022-01-19" version="1">MHFNFKWLTNVFKSPRSSRAPGEAHAMNNMENGFSAPSRPPPGYPPFFAPPLPPSGPDNDKKPSQKRFQPTADDQACAGMWSIYIGEAERYDKSLVEGWKGDMEGMVIFSALYSASLTAFLIESYKTLQPDPAQDTVFLLSKNIPTIIQLDRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7M1</accession>
    <name>A0A8H5C7M1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000227">
        <property type="protein sequence ID" value="KAF5336636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7M1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5336636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="397" mass="44393" checksum="3439DA9F706ADD4D" modified="2022-01-19" version="1">MPSDRQSAFQPHPKPPTSLGVLRVLSSRAGVRVSPLVLGAMSIGDKWNSFMGSMSKEDSFKLMDAYFEKGGNFIDTANNYQDETSEEFIGEWMEARNNRDQIVLATKYTTCFKVVDPDIKQTTNYVGNNTKSMHVSLKHSLKKLKTDYIDILYVHWWDFDTSIEEIMDSLHNLVVSGKVLYLGVSDTPAWIVSQANQYARAYGKTPFVIYQGKWGITDRSFERDIIPMARANGLALAPWNVIGGGRLRTDEEEERREKSGENGRSSWGSDWKRTPEEVKISRALEKVAKEVGVKSISTVAIAYVLHKTTNVFPIIGGRKVEHLDQNIEALDVSLTDEQIKFLETEAPSFDPGFPFTMIGDGTNIFRLLAAGTYFQRQPYPRPLGPPPAVGPDVVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8U9</accession>
    <name>A0A8H5C8U9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8U9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22555" checksum="FC37A36441244FA0" modified="2022-01-19" version="1">MHWPHFVRYDPDDFLPKNPDGSYTVVDSPTFVEVWADMEKVLEMGKAKAIGVSNFSVKNLEILLKHAKVVPAVNQVEMHPYLAQKDLKAYCKEKGIAIEAYTPSGLQHVRNDPTIIDIAKKHGATPNQVALAWNLARDVIVVPKSASEERQRENLFLPTLDEEDLQRIDGLDRYQRVCPGHFPDENGIVMGWPVEKLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAG0</accession>
    <name>A0A8H5CAG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000200">
        <property type="protein sequence ID" value="KAF5338119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAG0"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18548" checksum="DC691C6F85ACE68A" modified="2022-01-19" version="1">MFRTSPNSLLPPVNPNTALFPCSSTKTSVSRGDNTHIPTYHGSLNATKATHLHVRHNNLSPNNLLMSYRDNNGNLKVMTKSYFLSLCNDISSREGYPHFTGHSFCIGGMTLLLQDSVDPEYVKMYGRWKSSTFTRYWRDLHTCASVHIDRVYTCKHLHQRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBU0</accession>
    <name>A0A8H5CBU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_012997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="7">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="8">
        <location>
            <begin position="236"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1304"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1238"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1413"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1429"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1458"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5337657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1488" mass="162638" checksum="603331C141D31D16" modified="2022-01-19" version="1">MRLLNTSTYVLQEFNGPSIPIYAILSHTWDDEEVLFSDLRHSWSRDAATRKKGWQKILGTCKRARDDDLKWVWIDTCCINKESSAELSEAINSMFRYYRGAFVCYAYLADYSVRRDGYPDMGQGQGVRAGNAAFRRCRWFTRGWTLQELLAPANLVFFDAEWKDMGTKIGLKEAVSRVTRIPLDVLLHGDLRNISIAAKMSWAAERETTREEDRAYSLMGIFGVNIPPLYGEGGPRAFVRLQEEIIKYSNDQSIFAWSATFDDDNPWDPRLTHRGLLARSPSEFKASGDIRVSLFRNKLPYSLTNQGLHIHLPMELVPDFPGQPLYDLYIAYLNCEVQSSNERLGIFLLKVPNSEDNYERWHPDWLLVLSGSPFHHNGVDMKEIYVEEFPDSGAAAYPGLYSKRSASYPKSFSGGGRSSNAKHIVLYSSKTESIGPGDIQQLQTQQNTDGSSTYPSRIGSPALGRKYSGTEYQVDYRPSSSEDPVKVKFILIRDSLGRVSLSTQHRRESLSPWSSPDLRLHRPPPSRRSTSEDSFSPPRDQVIVPVNETESLLITARRQVQHMRLEDVEPDSDIASCCRLEFESIPVHWGQMVQTPESESEYSFSSLDCSSGDERIIRSASRLSFRSTDIPIPKKESSLSIELGSHEGSISLLSAHIPEAALFRPKWKPEAILGGSSSKHCEVVIPANINWSLAHLGSRTRTTLFPPIFPPFPSFMSSSSSSSPTSTSSAAATSSSAAGGLSAGGGNLKVVGIILAIVSGLLIGSSFVFKKKGLLRAQAGHAAGEGVAYLKSPLWWTGMIMMILGELCNFAAYAFVEAIVVTPLGALSVVICAILSSFFLNETLTFFGWLGCGLCIIGSVIIALNGPSEQSVGQIREFQKLFLAPGFLAYASVLIAAALVIIFYFGPRYGKKSMLWWIMVCSMIGGISVSVTTGLGAAIVTTAQGENQFKYWFIYFLIVFVVVTLLTEVYYLNVALALFNTAMVTPTYYVIFTFFSILTTIVLFQGLKSTPSAIITLVMGFLVICFGITILQMSKVDPNELGTMAKLDRRSTLLLQAARSKTESQYQTDEEKSVLGYEDPGMDALRGSLHGTVGSIMRARRISQSSRAGTIRSRHGSHPFSSGFAPGSMSPGRRRDVDLSPGPGGLKRHQLYDAPMPSPAFTTTTVATRGDDGSSVRSPSFTSTTSGGAGAQLGTKKPTIKFGSQDVIHSYHPTTGLGGPDLEATHESRPTITRSPSGGAGLGTPGAVMHGGGYPPARLDTMGTGDNKTMSQLLTLAESPVEERAGSGEGLPRGNALMLQESEPHFASGSSSRSKPGHVNLDDDLDREVKSAPPVQKGFPRIPMPGGRKDSRDVFLPDSNSTTTLMTFPSVTDSARSLDDGDLPDEIGRSSGGGKSQHHSHLHLNIGEDSKTGHNHHSHNAKKYPRGAQDQDREETRRLFKKNADGQESTDSEAGGNSPVSGSTEDSYQLMQMGGIRLVHQTPGGHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CC30</accession>
    <name>A0A8H5CC30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000188">
        <property type="protein sequence ID" value="KAF5339075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CC30"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5339075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34467" checksum="708AC9568713CD68" modified="2022-01-19" version="1">MHTTLPGHSFLVNAFPASARVDASLPLTVVSRYESTTKHTNFAKFHEGFGKNLKLGIHQDAQNRSKLAEFWRFYLTKATDEQTSLKDYITRMPEIQKSIYYLTGESLAAVHDSPFLEVLKKKGFEKEGLELEETEDEKKAREAEEAEFKELCTVVKEALGDKVEKVVVPNRITDSPCVLVTGQFGWSSNMERIMKAQALRDSSMSSHMASKKTLELNPRNPIVKELKRKVAEDKADKSVRDLTYLLFETALLTSGFTLDEPTSFAKRIHRMISLGLDVDEEEEDAPAITEAPASSEAALTSAMEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEW7</accession>
    <name>A0A8H5CEW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEW7"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40694" checksum="4FAB8B1A166239CF" modified="2022-01-19" version="1">MEATQTHTQSQFQFQTGKIPVDALGTELFYVDSGPPVPDSNYTTVILIHGSGINGKIFEHLVPFAQASSSSNSNHGNHGLRLIIPNRRDYTFSTPYTDSELEDLKAGKEEALQRTGKEMVEVCKYLIERKMVCKITDDGEGKGKGGGKTGGKKGGIVFLGWSMGNATVLSLFGWPEAVPSQGGNGKEDLELLDAYVRRMILWGEFEIPEEMASNFGEWVTDYWDHPDLSLREASSACLEYTTKRPKNSRPSIRNLVVEDPNPNSTTLPGSGLPRSDIFEPAAQGRSEMPMYFEPMQGTIKKQAYKALWNPDPEGGFVLPKVDVVWLTGTKAPWYCVWGWEIDGANHLAQWDEPEKFWSALVDAVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFR8</accession>
    <name>A0A8H5CFR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFR8"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71816" checksum="029A8D0021BEE944" modified="2022-01-19" version="1">MNFPAALSLAGIDAFLTDEQNREVRNALLREEQMIASLDAEIAEAYAALEKLKRQRNKTQNFLHLNAAPSESELADIRTAITQREMRLAELEEEIGQVKLGVDALVGQQSDADQLSSDNSDAITVQSSLAQVDTEIQIHKAHLNHLMRERDEVLSDLDAQRAMLSPLSRLPLEILSTIFINCLPEEEYLNPHPKDAPLLLLQVSRGWRDLALSMSSLWSSISVRAGEDRCCPRKKLIETWLQRSGSRPLHFEIVENIAYDSTRELGVESFTTSADVLALFLPDFDRWKSVSLEYKDWRLGDIGFKNIPVDHGPLLLERLYLNRDYWQASVHPAVGGLFSGPRLRSVAWDGILNGYPNPAEIMPLHQLHELDLSIILPSQQFFSVLAQIPNIVTFRLSVSLGSKEDDWPELAKTPLTFSHLKSLRLLTNVMDERILDAIIAPSLEEFKVARPTVAWNGFTPERCWSHDHFKVFWQKSSKFSLKTLDFTDMDILPAELLELLQLFSSTLESLVLANDHVQDKCVDDAVLKALTPTPNSTMLCPHLEFIKFWDCTASMDGLAAELLEKRWEGGDDIAQLRMVLAYFGDEEKNSDNIRRLELAHQRKRGLTLLRPKKYETWTVSRAENVEENIVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGR4</accession>
    <name>A0A8H5CGR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGR4"/>
    <dbReference type="OrthoDB" id="3063894at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="419" mass="46656" checksum="F4CC718CA71972DB" modified="2022-01-19" version="1">MSVETNAFWAYFDKGKLQNSSQHKTWCKACVNNHLEQGKEELEARIRNENEATKQRERKAARDEAHKQIGSLHGEKTVLITHILGSQKGKGSSGSFFTAFTFTYINPALTPGSPSQPLCRWDQFQYLLLSVSRVETIAPQAKTKAQRQRDGKAKDGPATHSNKMMALKRQLSAASSESPDTSSTEPAPRKLKQASLKVCSALEMLFSKAEIEAIQTQALHAQVSSKSKETIFKAPEMLRLMGMLRKDTIQIIPTANVLGGWLLIDAAARIEKKVEVILKEQELGMLTNQWKNIRKNQIAAVCVNHDYKLYTIDLLKVTAESKDGDTQCAQFERMIDRVENVYNCKVLFFVMDDNGGSKKGHVELGKKCPYLILPLCCQIQVPNSGANTLFSFSSNLVTTSKSICLGHQFVKTPPFSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHT1</accession>
    <name>A0A8H5CHT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">beta-glucosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_012584</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHT1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034576594" description="beta-glucosidase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="785"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5341514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="865" mass="90979" checksum="3024B2F0EB483F47" modified="2022-01-19" version="1">MLLLSLGLHSLIWAALGQTTASSSSIRASTGLSSVSAGSTAASTSFSDSASISATSALSLTTSPTAVGSGSAVFSSVAASSSVSLSASASAPVSSGVQNASTLPPGPPQAPIPGVFPATDPLNPPSVDEITVVPDFAPAWAAAYEKARAKIADWDVEQLVSTTTGVAALGITARCVGNIASVNGSNGWPGLCLQDGPLGVRLADRVTAFPPGFNTVATFNRSLIRTRGLFMGSEFKAKGTNIALGPMMNMLRVPQAGRNFEGFGADPFLAGETAYETVLGMQQGGIQVCAKHYVNNEQETARTTSSSIVDDRTQHEIYTHPFLRSVMAGAASIMCSYNQINGTYACENDKSLSDILKGEFGFQGFVVSDWGATHSTLAVVKGLDMDMPGNGGLRGTSSFFGSTLEDYVNNGTIPLSRLQDMATRIVAAWYFLHQDSPDYPPTNFDGNHQSNEATNEHIDVQENHKTVVREIGQASTVLLKNVNGALPLKKPRTIFLAGSDARPGIVGPNGATRGQDDGILGMGGGSGAATFPYLISPYEAIQRHAIEDHTTISWVFDDSDLNDVRSMAAGQTVAVVFVNAFSGEGSDRTNLTLFHGGENLIQAVASVNRNTMVVVNSVGPLIIDSWIEHPNITGVLWAGVSGQEAGNAIADVLYGDFNPSGRLAFTIAKQQADYPAGVVPAVPGGIAQVPYNEGLGIDYRAFDARNIAPRFEFGFGLSYTKFSYSNLRISRASGSDGDQSDLAANWEAGQANPRTVGSSTAFWLHRPAFEVKFDVQNTGDLAGGEIPQLYLHMPSSAGEPPSILRGFTDVVLNAGEKKTVTIHLSRHSLSFWDTGAQGWRRPNGDIGVSIGASSRDFRLTGTIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL96</accession>
    <name>A0A8H5CL96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000133">
        <property type="protein sequence ID" value="KAF5343805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL96"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033989994" evidence="2">
        <location>
            <begin position="31"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="62062" checksum="3AC5DA5D1EEBCA81" modified="2022-01-19" version="1">MALFAGVDFNIWADILLAWLQATGLSSVLSSDRPNDAEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLRMTTAKAIWVFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFNRVSAAGIPTDNPSGNSLTKITNFLIVMFIISKLPPRYEYLINMYTQCRAGKSEQAKRQGQAHLTHGDMSPMMHTVTVVDTPAAVDTRTKRAINLARDIGARPSGETVATLEDVVMSHPDLSSFTSLTPAPRPKRTLMERIYWNNLQSSSDGWGDAGNWNGWNGEYPGTQTGSDADMACVQEEDANSNEDTLVNTSELGSVFGSTMTESGAKVPQDTRTPVPLIDRLAQDPAADILQCAMHLGERFQNPEDSLHIYGEPLRTALNTVAPTGTLSLAQRIAAARSEMQSGSQPAHPNGMTTQSLPSSRVVSPTPGMTSTGWEWLTPHLQNEDGRYDELIDWQRDATIRLGGMELPSRAPTPSSMPELQSMSPSLSETSDLEYMSTPPSLGRMSLPTSPVEDTSSYGTPSPRPSTPVMVTVNAANNYGWSLDSEVSGMDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLH4</accession>
    <name>A0A8H5CLH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_012884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5343997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLH4"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5343997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="174" mass="18401" checksum="2E156B56F59869F5" modified="2022-01-19" version="1">MSKTIKDLTAGTAGGIAQVLVGQPFDIVKVRMQTSPKGTYSGMMHCAGGILKNEGPLAFYKGTLTPLLGIGVCVSIQFGVIEYMKRFYAERNALNGVGGPGGRNLSGDQLFISGVLAGLANGFVSGPVEHIRIRLQTQQVKNYPYAGPFDAIKKIYTAHGIAGIFKGQGVTFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMZ3</accession>
    <name>A0A8H5CMZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMZ3"/>
    <dbReference type="OrthoDB" id="5552562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="614"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1145" mass="129827" checksum="09FFC0DED4FD929E" modified="2022-01-19" version="1">MATRTQLQTETLEQQEDDSSPTYHMRTPQGNWDSSSQRQRSILNPLFQRSNFPHGPGRTLRSVQRFSSGLGNVIEENPRHNIQNPGPIQEGIRTRNTDPGTRQSPRALGELPTRQQRSDGFIQSILTPGGTVRRPSDPQRRVSFSEDNRSERVGGNIGGNGHGRTAPMQSETPARLPYWEQPIDDGSGDPRPFRERWESLVGTPYLPPNVPVGPRQSYRYLDIPPPSARTNETFDSQRTATEYDFDAMSSEEALETFVVLSRRLLNRLCSVTGENPGYDEMNQADYVRTIRRINSAAHGQLPREIEEFFRNLRNEWDLRHLSVLAGHPRILRIVPYEPKLDNIDQEMLDMYVYDDTSTHVPIPERDIGQSEGEEAPEDNQTLVPGEDKPLTVEEQEAVVLALHYFRQLTGEKLDEEKALEEFKILFSGTELDGLLKSPQREEPLGDLMPRSDEEINLEEAVNPGEAEQTALTHEIPSQSAHQPRFDILGHEIPSRSAYQSPFDILSGIRTFTTPPIRSLLVPGQMRPQGYPYTPIPKRIRESRQAESNSRVEERERSIAGSIKTPGVIADEKQSRKQQVTLEEVEDEDNIRRKRWEARRQQVIIEEVEDEDNIRQKRWETSGPSSETRRTSPPRYTTTEKGKQPIREGEKTSEDILQAASALPWRERMQNEANELRHSTAFDSISQRRTNGDSNSRRDLPPHLPSASGAPPRPRNFLQHRTPIGPNEPGNNGFWQRVTVPREGNRAGGEPPDEPPIPPNRNFPRQGPPGPPGQPGPPGPPGPIGPPGERGEQGPQGNDVPARRDDAHDRLLREAMNRESKLEIRKPNPFDGTNRNEFRSFISDCNRMFTAKPTLYSTDDYKVAYASSWLTGAAARTWENWVEREMDDIIYNPSLHEWDAFVREFGRLFGVHDEQLHAQAALDKATQQPTEPFADFLVRFEDASLKTKFNDHALRWTLLKRIRKDLRNRLTNNGMIPQSYTELVDRLLDIDGAREAFTDAGLLDPFIPRVPVVPVVPIQPIPVQPIPAAIPRALPRGRNANPQNNRAQGNTAQAQEHPRKPKVIRISKQERDRRFANNLCLGCGEPGHFARDCPNEEESQEEEPLVGRAAFSVEDNEEEALMLIDVDGTLFDLVEEEEQGNENGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPG6</accession>
    <name>A0A8H5CPG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000111">
        <property type="protein sequence ID" value="KAF5345530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPG6"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="70059" checksum="CBFDEE2DD4D170BB" modified="2022-01-19" version="1">MDVVKAVETYVTKMISESSAMKVILLDSHTTPIVSLASTQSTLLSHQVYLTDRIDNTKRDRLPHMKCVCFLQSSDASLEALQAELKEPKYGEYYLYFSNILSKSIIERLAEADEYEVVREVQEYFADYAPLLPSLFSLNYTPSVLNALYGNSPNSWSPEALERSVQGIIAVLLSLKKKPIIRYEKMSGMAKKMATEVHHRIQSESSLFDFRLTQVAPLLIILDRRNDPVTPLLSQWTYQAMVHELLGIQNGRVDLSKVPDVRPELAEITLTTSTDPFFQSHHLATFGELGTVLKDYVQSYQSRSLAQSPSSINSISDMKRFVEEYPEFRKLGGNVSKHVALVGELSRLVEQGKLLEIGEVEQGLATSSGADYKASDMIKDNSISPTHKLRLVILYALRYQKTQAANIASLINLMLQHGVSREDARLVYVFLNIAGTDQRQDDLFSTESLFAKGRSALKGLKGVENVYTQHTPHLSQTLENLVKGRLKETSYPFVESPGPNASLTRPQDIIVFMIGGTTYEKQQLLHFSISKAYLRQVLVLLLVLVQGYLELIRVSAEKFPASVYEPPPESASNAPVLNLNLGGVNVSLGGAQPGVYRSSGEAVGVQADGIRDGVMNLIGKVKQGVDRIAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQA5</accession>
    <name>A0A8H5CQA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQA5"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034678863" evidence="2">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="21421" checksum="8CADAE8AC829C53C" modified="2022-01-19" version="1">MCTGNFAQLALALARLFESASSTGSIRDTSFHIADRQAIVSLLTFNLGAFLGRIGDRVGSHTRLWLILGTFTQALFTMAAALTIWKSGQMSIADDRGDPAWTNVLSYSSLTTVWVELVTDPKLFHHRIVKTRDHKLIAAVSLFTGAFASRAILAQTGAAGALGVACGVRVLVALGWGFVLGKGGVEKGGKGSGFRPNSISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQZ6</accession>
    <name>A0A8H5CQZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQZ6"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034348453" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="53"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="68163" checksum="6CEAB5054E1035FB" modified="2022-01-19" version="1">MVRIAFTVAAFSLTYAHARISSVSRTVIINDSPYYLPTEPLVTLGQDTHNITGDPLPFTLLVDIGVGSNVKSLVENWEAIDDVFNKEFLNTVVLAGSSLDASGDLMSFLNESDTQMLLTPTDMSSALSPSIFSQLADTDLPAGPYILAHDATGSPAVYAPLRLHYDHSQSFYKSTVMKSDGSYEVVSASLDTDSSPYIAVPSRVHTLGKNDSRLPLAGLRVSVKDLYYMKGLVTSAGNRAFYATYPARNSTGPAITRLTDLGAHMVGTTKMVQFANGDRATADWVDYHAPFSPRGDGYLEPSGSSTGAGTSIATLDWLDVSLGSDTGGSVRSPAALNGVYGIRPSVDAISLDEVLPLSPILDTAGYLTRSPKLFSSFGKAWYGESFQSYPAFPKKLLVSDDFLSVTDAANAVYSPWIEKLRSFLGGETVGNFSIEGIGIDHLFAYYQWTNVGKPLFEDYAAQNGGRSPHINPQVRYRWRYGESKGADGYAVELEKRETFENWTLSNFLTGNAESCTESIFLYLINSGTYTSRETYYSSPFIIPFGFSSSRVANLARSAEVVIPIGQIPFHSNITEVEEYLPVSISLVARRGCDFVLLDLVDKLADEGLVQEVHQEKPQIQLHAICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSH1</accession>
    <name>A0A8H5CSH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSH1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="15437" checksum="6B47064BD9A77C2D" modified="2022-01-19" version="1">MNQRAPPSLTSPIPSQTSDYFLKVAHYCQRRQAATQPKVAMRDLCHRTKLSRFGRRQHPYTKKSKTKRILVVDDRGFSDAVAELQRQRPPEPYPEFWVFMVAIITLRLVQVIVISIAFFRGVLGGHNADESQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTP4</accession>
    <name>A0A8H5CTP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013709</name>
        <name evidence="3" type="ORF">D9758_014874</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTP4"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF3">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5356706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="204" mass="22594" checksum="12B14DFC052381AC" modified="2022-01-19" version="1">MDKMAASVIHSSKKLTQGRFRKDPSASSIVKNINQWLFYNVLPVFSLILLLGTGLSVTQWVSPTFLSTVNSSQSSLSMIAFSAAQTSPQDELDKYFHFTSHPSKMTVDPLEWWHARRDQFPNLYCLACDVLCIPGKFSSIIAGQILISFYLGSAVAIERVFSGGRDTISLRRSSLKADTIQALMVVKAQLKMARIAITEVLGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU06</accession>
    <name>A0A8H5CU06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU06"/>
    <dbReference type="OrthoDB" id="3005567at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50266" checksum="C49837C862E3A702" modified="2022-01-19" version="1">MAVEKLDLDVWNLILSHLLTTDLYAVALTSRAFQFGVIPRLYHTIFFRTQHARRYPGMMTAFQAILQHPELAMQVRCVEIRALPTNTKLKATFLSECTRVIDLCTELSSFKCTVPVLPEFLPSLQGLKDGLRTLRIPGNLSTPEAEMLLKIGDLDSLSIDQGTWNVIDILPRWTEGSSLTELILFMTKELNEDVLGSVLQCLRNLRSLHIVGCPQIDHVSVLRLCKHLPALESLTLNASDSLCPLDDDEGFPKLPRLRHIAFDTRYSRSIPPALDALYLVLECLQDSAPCLSSFTIRLSDKKTLVDYDFLKKLLKQHRRTLRQLAFLDCSLDMKHVTMICKNCVRLERLELPFPLKELVPFASALARSDTLQTIVDTQAFHGAYISLTPQNVRLLMEAAPALSTIISDRRVWKGYSDGVGRLNNISFRTLPTQGASSYWFLPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVZ1</accession>
    <name>A0A8H5CVZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVZ1"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5349009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34110" checksum="F42116AE6DF9ACA4" modified="2022-01-19" version="1">MHTTIAIGNTAPSYKCRSQTMAVRLVSLGDRGSVRQRRCLPLSLSALLPRPQWGVGTLSGLAATATARKASTSPSGASCGGVLALFRLAPAVPQQVGKPLEGHTDWVRSVAFSPDGRHVVSGSEDMTVRIWDMQTCQQVGEPLEGHTYWVLSVAFSPDGRHVVSGSADCTIRIWDMQTCKQVGKPLDGHTVWVNSVAFSPDGRHVVSGSDDKTVRIWNIDPSNPNLIPASISQYNKKNQSCSINPQGWLCTAEPEPKLILWIPPHLRFGFNDLRQVGTIPAGAKNIGVKVDWSKFVCGENWTSVWNDNPDYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0A8</accession>
    <name>A0A8H5D0A8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0A8"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="270" mass="29385" checksum="A65A26EEC1FA83F6" modified="2022-01-19" version="1">MLTIRQNVMILWLQCGKKGERRLCALSFDLNGSRLPRFSVKFGCFLGTCPKKFSTPKARRLHLIQAHHYPKEYFFAVTNKGVGGLLKRWGEGASMIRGEWKQREGPQRNDESDDDEATHEEEMEDADVVQSSFNDIGFDTGSTPAKANAQDNLDGLADSMSSLSLVPSAIRFGRGGKKAGLAHGRAHDVDTVASARGQKRGRGGGRGGVNKLEKRGEIPNGQDHEHIDMGAAVNHSSGRGRDIHRGRGVINLRGLGGGRGRGRGRGRGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1S2</accession>
    <name>A0A8H5D1S2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1S2"/>
    <dbReference type="OrthoDB" id="3099184at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="169" mass="19132" checksum="F37A1BF078AEA4C1" modified="2022-01-19" version="1">MSVFTAFLKRIAFNYAHHQIASNGRLQLVDFIEETPIGPVYSAFDHDADQPSWFAVVCIIKYDDGSMDAGVMEGLKLLGKASHPEVVRPWSIFEETVEEVELAFLVIDHLNEYVPRPSTPIFWMSPRTESYSDGVMTPASSSDDLFGFENSKKEGKTKGFLGRMVRNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D515</accession>
    <name>A0A8H5D515_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fusaric acid resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D515"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="713"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="856"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5353705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123102" checksum="9FD5E17A08968097" modified="2022-01-19" version="1">MATLEKTSSRDKTSLETDNNKVEHDKATPSLGSSKDSQTPKGASATKETTSSSSPNATANGSTSQNDPSKSLFTKLTSALPPWVTTNLQNPRSLKTWLRCWLAAWVGIVIFLPHKSLNTLGASAFFSMLSAFFLPPNIPVQLFVFMISTMLIGILLGWGVGAAAMRAASAVRSQALLQAATLQLQQSIQSNPALQANPSFAQTDAVFHGLFLDTRSSVMFGAFLGVGVFFFGLIRAYAPKLTILSIFGTIAVDIFCSIGPLFPAPQYNLLRSLLISSTCYCAVGLILTIFVFPESMSHSALRTFSDQLRRAKALIEIQDEVLKSKPEELGRGTVLGMKIEGMRAGLVGVQTQLSTTAGFMSLEFSWGKWNSDDVKDLLDPMSSLIARVAGLQSFSRLVGQTPVIQGKQPDSVDTNTSTNTNTNTNADANPANASSPSQGAQGGLKKALKNDTYLVDQVNKINATLESTYNCRIIDLLPIISKASLHLREACVYGCNCTIKKLENINKHRWTKNPDQDGSLVREMDGSIEKLRGVLNEFRETHRLLVLEPFMPMLQRTFSSEDEEEQEELAISLPLRSLYISYVFCTNLVAVTEALLRLMELMRATVAKRRVNRLWAPKGLRALWKLFTVRGDENDRAALGDETLPKGDETGELEDRLYRRDPDSRAPTNFMQKVMNSTHGLYHWTKTAEAKFTLKFTVASVALWVPAVVHRTAHFYYVERGFWALIMLQTTMNIYAADQIYNLVTRLVGTFVGLCFGLVAWYMGNGLGNGNPYGAAAATGFVMVPMTFIRIFAPIQYLPGVILTCVTTALIVGYSWVDGNLPQYSSPGIGWNIAWKRFTLVVIGSAASFIMMMLPPTSGRKAVRLRNASIISQLADLYGFLISTWISTDSLKEGDSSSDEDLPAADTHVNSRWLAEFRKRLLDIAGAVTATRSLTAIATWEGSIRGKWPVKEYMALLDVEAEMITALAQLGGALTHMDDEWRVQFLHSTRALNPNFITDVMAVFSLISQSLRTAEPLHAVLPQSLVGRLMYHSHSHHHMHARSHSEGTDSKHSSVSLDHVASIDYMFYAAGVVAMFQLLQSLDELHRLTKELCGEVPLRGFTDWRDQFERSHTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D586</accession>
    <name>A0A8H5D586_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D586"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="12166" checksum="B473FFF4CA7D0369" modified="2022-01-19" version="1">MSSKLFHPIKLGDVALQYRVALAPLSRFRANEKHIPLPTVKEMYAQRASTPGTLLISEATLIHGRAGGYAYAPGIWSDEQIAEWKERYPSLRKATRFVSLPSPSFMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6Q3</accession>
    <name>A0A8H5D6Q3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6Q3"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="34125" checksum="47748601BA85ABB6" modified="2022-01-19" version="1">MARSGYVVTHTHAEAVIFKDDVLANYIVPVNADATHHRRRSTTKTNTPTTSTPSMTPDDSPLRSRHSSLSSIFSVTSSSSRRSSCSDSLATKLRKRLLKLAHKEQDDCSPVEDLHVEADHSIEMLPGAQGLLEIVHVDDHRLSARSAMMCSGSSDAANECISSAGITLPRVTVTPEDLDKSSKPSAVTDGPLVDPAVEAMLAVIESILVAADRMNRIPSELVVFEDSPSGIRAAQATGAQVIAVCTGSHPWEELEKCRPNYLVDSLKDVEIRAERDFHGRLQSYRLFVYERGVGMSLYKVQVASRLEQADEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7C7</accession>
    <name>A0A8H5D7C7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7C7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="181" mass="20130" checksum="54A7D16D21B43041" modified="2022-01-19" version="1">MKDGIPATSSEVGETPKPTAGSEVANEEALDGKKTLTILAEIGTPFLAPISSATNCSPPETVIASLQYAKQTQGTPEVQLLVRVRYDENESTISIFRLRAERPNHAKRWIVVFRISRKSTISAPSIHSVHSRCPTSGRGFLRIQDQMITAWFKLEDRPLRDFRFEMNPKTNSIFVGAAVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DAI1</accession>
    <name>A0A8H5DAI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DAI1"/>
    <dbReference type="OrthoDB" id="79830at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5355267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="893" mass="93674" checksum="66AE38F737829BB2" modified="2022-01-19" version="1">MSGAIRSKRSTTLRNIGSPYAGGRPVSKKSSWSTSSLLSFFNPLNYLRSSSTSNVEDSDDDLSDSSAESAAKALSARGQEISASIRSRNDLVQQQQYQPPPPPPNASNLPPPPKSSTFHPPPSSSQSPTTSREKGNDSSTVKNGLDAVAQFLESHGGQELSRQDAQNLINIIKSEQRETFRFSSSTPSTPNRGNSPLPSSNGSFQFSLPSTSTTIDITSPATSKSLKVNPNGRYRYEGGGSAKPARSRNRFQSPAFGSSRGTPERIVLRDSPEKEPIKTDTKRRRVGEISSSTASPSGLNGSAGSSSLQASQSLPFPVSNVNGSPSKASSSNEVTSKVNGTSHPVTPRLRTSMIHTKPTTPAIPSPLRQTWGQSGSPPSRSESEESQPPRQTRAANFMTELIKEVTPVKRLEVSNPYQAARPVPASGPSKPRPKRVRAAKPAPKEVNGVKPSDVKDAEKEKEREKEYSAQAIIEATIPKGSKRSRPPAQSEGMNGTSSVQKLLLPPQVEEVEDEEDARRHSKRAKPNGLVNGSAKVPPTTSGPTITEVVDEDEIMADKTAAAPSQIIEPKEQPSSSAAPTSSSLFGVPAPTTAGSSRSLFSNTKATSAPKEPSKLRFSYQPDVTPSPSTSASSTPAPSLFPPAKPSTPAPSLAAPLFPSAVASASASASTSSKKDPKKFAASIPVLELPVYSFPTPPLASGSGSEVSSSVTVKARGAAKTAPVSSLPKFDFSKPTLAAPKAVPAPAPAVKAFDWGAAGMKPPTSSSGGTWTCNSCMLQNDNSAADKCKICEAPREDKKSAAAPVKAFDWSAAGMKAPGASSGGSWECGSCMLQNDDAAADKCKICEAPREDKKAAAPAPKAFDWSAAGLMKPQGASLGLDMLDVWVEEFGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4F0</accession>
    <name>A0A8H5F4F0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000397">
        <property type="protein sequence ID" value="KAF5323187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4F0"/>
    <dbReference type="OrthoDB" id="3264316at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF161">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN RICESLEEPER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="114"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5323187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="23047" checksum="62B04EF4887B9244" modified="2022-01-19" version="1">MIEQRKTFYIIATACHPAMQLRWFGSPESDNYIRASIVLEHVFKEYSQSVPPKPTGVASPKKPSTRQLPSDDQFLQSLLTIGSSFDEQSSDGVPLASEYERYIGGEGGAGDIKKPLHWWKTHTGSKDGFPIISRIARDFLAIPGASVSVERLFSSSRHLCSDLRSSLKAEMTTSAMCSKLWFKQGMFDFDVKRLVSAEYEGKKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCL0</accession>
    <name>A0A8H5FCL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_015492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="JAACJM010000325">
        <property type="protein sequence ID" value="KAF5331483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCL0"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="115"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5331483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="492" mass="53489" checksum="D60651512422A7BD" modified="2022-01-19" version="1">MAALRQAARRSLFNPVHQRSLFTRSSPPPPSPLRTGVYATAFLLSTGLFAVYYFDARSAIHRYVLTPVLRYAFDAETGHQIAVKVLRSGLGPKDTVQDDEKLKIEASLFGCDVYRLAAGFDKDGEAIDGLLDLGFSWVEIGSVTPKPQPGNPKPRVFHLTEDSALINRYGFPSQGHNTVLSRIRARIPTWLSPENTNASLRDGSLLAVNLGKNKTSPADSIDDFVAGVRTFGPYSDVLVINVSSPNTPGLRGLQNKSSLQALLEGVTKARDSLPNSLLTTTKPRLILKIAPDLNESELVDIADVIRSSNIDGVIVSNTSIQRPANLVSANHTEQGGLSGTPIKTMSLSALRTLRSNLPSSIPIIGCGGISNGDDALEYAKAGASLVQVYTHFGYEGAGACRKIKDEIVERLEKEGVTWKDVVEKAVEERSWRKPKEDATLKKGEGLGTVGQLIAEAEELKRLLDRLGRGWRVSLRVGKMVKLLLLLSLSYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FD49</accession>
    <name>A0A8H5FD49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FD49"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="309" mass="33116" checksum="F33FF6198F165F32" modified="2022-01-19" version="1">MLLKEMKVKKTTGYTTFNKNFLYTADQHLYAKRWEALVNSSFPTNDSPSNPLNIDIIQIIFWNDYDESHYIGPIKGAQPTGSEAWTGGMGHAAWLPLTSYYASAFKNGGQYPDISKDGDGEKLAQVGDPVGEVTGKELVEDTIWTITLLAEPANVTFEVYAYTPSSNANDNSSTIISSQTFSVPAGLTKLAMPIGFPDADEGIQSLSVRARVLRSASGSGSESQDEDTQQNQDTTDTADTLVMQLNAGNPNASDSNTNTGNGDAQRQGDGTGNGDGDAQTLAPFVFVKNPEKYNYNAWVGCVSSSGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLF4</accession>
    <name>A0A8H5FLF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLF4"/>
    <dbReference type="OrthoDB" id="3235815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64455" checksum="DA74DD4AC9B36B64" modified="2022-01-19" version="1">MEPKQLLQMIDLSDRTERDAIRALIDEAAKSMHDLKAYRNSIASISYLPDELLSNIFYCCILETPWHLSNWSRILFGLSTSGTTRIFSQVFIRNLHRVKSLQLEGSLLGMKHFFEDDADLKALPLLRELRIRAHGNEARDWRLPDYIVEGGCPLLHSLSLNCATFSSVALQRIPNLTNLELHYISSLNQPLTITELLGLLQNSPQLERVVVNGSVDDITPNLYVGDPVPLPHLRRLALVSSASVLTAVISSIAIPPTTSLDLVIRQRDDPPTIPSLKSLVRAIRMHLHHSNSLILRSLFNVSRNLLDIIEFNKGYDKHHFYLFVESMDYSQPFVRSIITKILDVLPLRDIQRVNVPSCMNDELTKNTWRTVFERLPMRPLVIQTGISDTMMAMLEGLLDTMLAYSNVGTNTSLNKRRRREARKEVRRKETARSQSTVDPDDVAQAVGDCFRLVSDNISIATRSSGASPPSAASSSSGPGILRLELKPEHHSHQTFEEANRPEIPKEYFEQLLAFLLKYRDSDFVGKRSGARVPMLVVERYWQMRLYYEDQLHQVVDKVVANGSILRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLU1</accession>
    <name>A0A8H5FLU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DCG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLU1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33243" checksum="0A29A438A8CE8252" modified="2022-01-19" version="1">MSSLTVHPAIKLLIINPNTTSSMTASLQAPVNALLASYKDVSCDFFTGPPFQPSVKSSFDSPVPLADIDLNAAAIGAGAIPSINSPADAWASAAYCLPFLRAKIPEYDGFLVACFSEHPLVQMLGKEIDDLRRQNSRGSWRKFVIGILEASVITSLGLLAQYSSHRQGEDASTPSFGIVSTGKIWEDALSSAVHSFLGFDGNGSPKSERFAGVETTGLNATELHDLPADEVRSRMSEAAARLVSSPQLTDGERKRRKVRVICLGCAGMTGLENAVREGVRSALGDEDAKEIMIVDGVLAGTSWLIGACRIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMK6</accession>
    <name>A0A8H5FMK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMK6"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5342715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139384" checksum="ED0788D1FB1A1F05" modified="2022-01-19" version="1">MPPNKNPRPESLSYLEPDAIPKNKRRKLSQPEVSSMTSNEISTHFDFSALSSKNATLKGRKRFGADLGLLKDACGTGTGIVGYGFKVAKIRPGDDDGSVELVINALGAEDQPQPEVLAVSVLVSDTSDYPKSHSYFSYSLSSTDTPPAVQKVIDSISENGNGKPLPDLVEKTLKDLSKSLNKSSGSGSCSAEAITVDSDDDGEDDLSDGGDTEPEEYFDEDDYYNSSSRDPHSLNTSLSSSRKFSLFKLQTDFVDTIASNYRPGLIRLGGDDFILSISLPVVDLTEMVEPRALAAWDRKLLKKPQNLVLLISGWTGMYPYPLGSSSSSSAKPPTLKFKVGLSPSYKPSQEHAKEACRNFGLIVMDAEDELALKKEKERAEALALAQWEASFGADGDGTDDIDANNANDSGTGTSTPNPNNAYPTPAEDDFGSDSENPKSKQDKEDKGTFEPISLSFSLESLLNSHFIKLVQIRQRWGLGWAGAEMVLKECESRQVGEGEVMGDKVLKKLVEGADREERKMGSERENGKGGSEGVGVGGRLPHDPLQQVNRTGGEQELNLPLTAFSYLVRRLMLVADYEALKPYVCDSTLCSYQYYSFGLGPSLEYEIIHNSSTVDLLVSLTYSSAAEGVLDEPLPVGIGLRVNPVDPKKIIQPPTTHRGFPVPNGAVATAGWTGAGAVEPKKPRAGPDGLVDFDELSMGERRVAIMVLIDSLPSIDDMKKHLDRKVRSGKCKPTLKEMNAQILPAAWLVLRWIVGSCLADLEEITSGEEHIKHIDDTTWRQYRFTVGAPDAEDKFKTATEEAQSRDANAKVYPSLYAFHGSPLRNWHSIIRNGLWYKTVTHGRAYGNGVYLAKQAEVSMGHYATAAATAWRHSRSRPQSCVTLAEVVNLPNEFVSNNPYFVVQHTSWIVCRYLLVKGAHYSETGELITSSKKKSEPTHAAVPYVQLDPTQAITLGGQALAVPEPSFQLDQLLQALHAQAQTTEDENDETDGEVFNYDYSANANGKGKEKVVIVLDEDEDEDDDAYIDEDGDIEMIDIFPSDSNHSGSKASASSKSKGKANANAKPADDWVHDPEWVRNAVPMLLPAPQAANRGATAALQRELKAMLKEQDSATSLKELGWYMPPEFIGDNLFQWIVEMHSFDEDIVIAKDMKKEKVNSIVFELRFPPDFPLSPPFFRIITPRFLPFIHGGGGHVTGGGSICMDLLTSSGWLPSYSIPAIIMQIKLAISNPDPRPARLASNWTQHYTVGEALQGYKRAAATHGWQLPDGIDSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN93</accession>
    <name>A0A8H5FN93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN93"/>
    <dbReference type="OrthoDB" id="10051892at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="533" mass="60288" checksum="D1DCCFDAEE162928" modified="2022-01-19" version="1">MSFLIPFPLPALLVEKSAVWCGLLVVGFATACVALRPGHMRKKRFWRTELAYLDTPNDSPLLGTVVISGGSISGILAARMCSQRFEKVILVDPEFRKVDQGPSKSRIMQYHSCHGFPNAFTEGICELWPGFLEKLKQRGGMADFKVHYNGVYVPAPDSLPITVNIRRSKLDPLLQSLLLEHYSDSDPSKLIIMDGTVQMIMQSPENQSIESVTVRMLDGSAVQLDNIDLFIDCTGNTQTGKKWLRLGPWLRYPMPQCLSYDPNMTYVTVTFSVSEELEEKLPVPGGYNSTTWFYTFRPHHEWCNAGFLLTKMDNNTVQFCCGSWGPYELPRAPDQLESFVRSVKGRDPVPDWVPTMVGILASQGKPEFERVRIPKCKYVQYHLMKKLPQNFVAMGDSVLQLNPLYGQGSLMAMLGVVTLNTMLLECKNRKLTPSFSREYFKTLAGRQAGLWTATKAVDYGFKTTTPVAGEKLSNGKIIRWFTDKLEAASETDRHIVSLVWQVRQQLLPENTLAQPAFLVRLFWVLFLQKMKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP83</accession>
    <name>A0A8H5FP83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP83"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="21259" checksum="0E7928AA036B1BBF" modified="2022-01-19" version="1">MRIVGQGVTERSSIVHTRRNGAAQSLQTTSKANVSAPEPRSVPRELNWVTLEVIEPVDALTVLRKPSHRKTFHRPSEAEPYISSGNTPVSQSPVPVPEIANLTNGSLSRLHENLAPKTPTTKTPVPLPSGADSVEVAPPITSSSLTTSSLLSSLSSSITVPQTLSSSTTVPAVSSSDPGPPLFVPDMPTSNEMGNEQGGGLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPJ7</accession>
    <name>A0A8H5FPJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPJ7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15571" checksum="4EAA06DA2F119730" modified="2022-01-19" version="1">MVRYTQSFPILHLPIHYLSTPSFVASPTTHSNRDDQLLPRTVPAEPIPGVTNSFKNDLKGHKPAASPRNLKDTHGDDFECRGLGNDAGAAKKISMAVPEDGLKDKNEKQKDIHDGSEAANAGTGNRRVEQGDGGYQSWGFDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRY4</accession>
    <name>A0A8H5FRY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRY4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="361" mass="39478" checksum="8BC43203A4AE9378" modified="2022-01-19" version="1">MTKVTDLLTTDTVIVNPVATLSTLYFIYGFYVLLFIIYLYLFLQHRRRQRDIDSGNGASGNLLYFPGVVALFVVSTCFVVFETQSSVRAGTIFFEAVKSGDTTEFAKYVTNDRLKTADGFIEGFLKIAAIAIADIMLTHRLYVLWDSRMVAIPLFTLILLLSGNVVFHLSSSCSPLQIASTSMIAYGSIDSSDHKKFAVINDGIELDNAFWIGEACLNGIITVLTAGRIWYLSKDIRSTMGSKFRKRYSALAAMIAPDSSGKSGLILPVSIVAFVIIRKVDIPVNPLQIDSLLPLLAAIAPTSILVMVRLQQAFGSDGSGDVEAANINISTIHFEEGNLSSDTSTDTSTAENITNRYKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FST7</accession>
    <name>A0A8H5FST7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FST7"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="939"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5347398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1151" mass="118377" checksum="BCEA48BE36C153F5" modified="2022-01-19" version="1">MSAHPPHPIPMANHHNNHHNNASSSSMAMSISNSHSNDYPMSSGSYNGSNSGSFNPASYTRHFLGSPISWRAGSLGFGGRSSGSYVGGMGPMDQLRGSLESRGMDPELSNACKIFDLQDELCRNYTCCGLHLTDLHALLEHFEQVHIVVVDAPGQGPQTRVQVPFDPQIVEVQPPYAQHQQSHQSQLSQNNLPHNLNHSQNLPSNQNPASTHNPQHYPTPVDPDDMELEPAPPLTPSSHSHTHSHPTSPATSHSSSSDASSPPVSTPNSLAAAYPGGFPYSSSSDSQSQGNRSQSQQGSAHTPIYNHSSSPYPSATSPYHSPYTSPYASQPPSPPHGFGGLHAHTSGVHGVPAYSQQHQPHQSHQGVSAFDTTLITSAGVGVGKVPGFQPSSSSLAGATTLPSQAQPGSAQQERKGMGARRPSLSLNLAGSMDGVESTANGSADASSTSASGSSTSTATATAASGYSTLTTSAGTPAAGYAFNVHPFSYNNGGHPTGHSTHGPGGVSPIMAGGMNANGMNSSMGSVPPMSPMSPMSPMTSFPSALAAALVDRSTTYGDLSSSRSMGGDPQPGMGYVTPAMLFSNAGTPEPEDGEADAEGDFEDGKGEGDEGHRGRGKDEKRDKKKKGGKGAKAGTGVAGSSGTKEGAIDGADTSNSISSTTAVSATSSLKKNRSLNPVGRPPNPNVKSHIKGGLSALATAGLAGLSGAGGVGGLILGASKPFKCPKPNCNKSYKQANGLKYHITHGSCSFAPPKDLEHVQALLDRKRKDRAAALSAQSSSSSISGFGPTEDGQGLESAPGSGWNSPAQGPSSPSVGPSATGYGFPSGAPSTSTTAPSSPTQANMNVGSSLSGLSNQGGVAPQASGLVGMGDDLEFSESELLALSQEAEKKLKPFACGIGDCTRRYKNMNGLRYHYAHTGEHGAIGLNMLASGIHECLQNNNSSKSHSNHHHKDRDYTSNYSKEREGRKSSQIRGLGSKPASRANSRSRTGTPLPPSAGAGAGVEGAIVSPTSQAASFAAAQIQQLHHAQSAVPPIPSPTISNTNTGSGTAIAASSSSSSGATSMPMPMSMLTSSTSTSSNSAPVSTTTSSSSSSSLTPTPSQIQAQAQAHLMSAYPYQQKFLELQRAQYAAQMQHQHQQQQQQQVQDPFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTG0</accession>
    <name>A0A8H5FTG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_010070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTG0"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="64"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5348043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="52167" checksum="1F924C5E24341684" modified="2022-01-19" version="1">MTTICTGDKVVLPTSPTPQPATIIISNASGKIVEIVPQRLSKDHFSSSSYRTPINFIDAQSSLILPGLVDAHVHLNEPGRTDWEGFYTGTRAAASGGVTTVVDMPLNSIPPTTTVENFEIKKTTTKGQCFTDVAFWGGVIPGNEGDLKALVDRGVKGFKCFLIESGVEEFPCVKEEDLHKAMKVLQDTDVPLLFHAELDVGDDHPHPQEEDSTLYSTFLNSRPQKLETDAIALITTLQKTYPSLRCHIVHLSASNALPLIRQARAAYPNNLTIETCFHYLCLSSLSIPNGHPEFKCCPPIREEWNRDLLWEALKDGTIDFVVSDHSPCVSELKNLDTGDVMGAWGGISTLGLGLGLLWTEARGEGEGQKRDVTIAQIVDWLCWKPAIHAGLGDRKGKLEVGFDGDLVIWDEEAEWEVREEELRFKNRVSPYVTKRKRLRGRVRKTFVRGNLVFEFDGEGEGRFGEPVGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUB5</accession>
    <name>A0A8H5FUB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUB5"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="97" mass="10668" checksum="E75E7D15E4B9F891" modified="2022-01-19" version="1">MRNLVIIQSTSPSTNPSPHFLSYLKSHDCNFPLHPELWIKADGKVPTCDWFIKRLKSILPNVNIAGHSLQSGGATSMAEAGVPPHLIQAARCWASYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUC3</accession>
    <name>A0A8H5FUC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUC3"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="347"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5349349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="706" mass="77656" checksum="2B8912042F001247" modified="2022-01-19" version="1">MAPTIVQFAPLPSQTHPSFWHKLTELKLDVLKLSDAEVEINGTYGVGRLIKDREGGPGAYVGVTGSLSVEEESFGQAHANPAIGNAPAKGTVKNYNTIEEFKAADKTKLFNEAADKIWTSVQTTRSTSLLNSFLLITFADLKKYKYFYWFAFPAFVSTPAWHIDDTAGWIGVSSPNSGYTHDQLTSIYDQLSKSPKPLSYFLVRSLSSDSIQVVPVEEFNATTDTPTSTSIGFIDPSAQAQNPGWPLRNLLAYLRVLHPSLTSLKILCWRDAEVARSADDWKSRVGTLTLGDGTSPVEPMDTTTRPNAVGWEKNVQGKLGPRLADLAPMMDPVRLANQAVDLNLKLMRWRILPSLDLDKIAATKCLLLGAGTLGCYVARCLMGWGIRTITLVDSGRVSFSNPVRQPLFNFTDCLNGGRPKAECAAERLKEVWPGINATGITLSIPMPGHPIPSSPASILEKTKKEVETLERLIEEHDVVYLLMDSRESRWLPTVIGRAKGKLILNAALGFDTFLVMRHGARPEEDKSGEESLNGPKRNLGCYYCNDIVAPADSLTDRTLDQMCTVTRPGIASMAASTAVELMISVIQHPEGVRAPAPRLPSNSNDYHYNEGEEGTSVLGLIPHQLRGYLAQFRNLHIVGAAYDKCTGCSETVLKAYEKDGFDFMLKAFNDPKYLEQVTGLDKLFEEGEKALDDLEWAEGEEDGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUM6</accession>
    <name>A0A8H5FUM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUM6"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="24191" checksum="23E5EA4F36377700" modified="2022-01-19" version="1">MTTLTGKLFSTFCSQRPPVLLLVPPATVSLRPIPEKMFAKLSLFAAIVLPLVHALTIDAPTDAVSTQPGTITFSGDGNDSIFTIELDHPSLLSKIAVANNVNPGEGSVNVIWPTLLETTGYTLEAVNVGNISDIFATSPTFNIAPQPSSASASGSRTSVSLSATNPPGGSASATAPASPRPSAPSGTTNSASGTSGSQTQSGSGSTQSSPAPSQINGNGAFAVQSNLGAVVLVAIGAAVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVQ9</accession>
    <name>A0A8H5FVQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVQ9"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="3">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5351550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="38577" checksum="42FFDBC90EAD3A38" modified="2022-01-19" version="1">MTLKLKGASSSATSVSWDDVKSPSPPPEFHNPQSPPTSWLPERDMKLFGATPLTSTSDIGLVRCKDCEKPILRSVITEHLVTCAQIRSGGKAGKAKVDEDSKKAGKKRKASPTPSDSQPQKKKAKPAPKVTKGRVKGPVDYDKQCGVINDKGLPCSRSLTCKSHSMGAKRAVQGRSRKYDDLLLDWQREHNPNFVEPVKKETKAEKKEKREREKLEKKRLAEETAAAMGVDLTKKSSGISSSKKTGKKAAAAAAIRMAEGMAEVVEENLDELDSDAEVDGLVSAVRSAKEKGVIAQPLAVPCDAGSWFVQRRERARCCRDLLLNSLVNGGASNVSGMSNMSMVGRATGLGVGLGVGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWT1</accession>
    <name>A0A8H5FWT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWT1"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5351597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11304" checksum="9337DA84199355BE" modified="2022-01-19" version="1">MKHIAAYLLLQVGGNSSPSAADIKKVLGAVGIEADDERLDKLISELEGKSINELIAEGNSKLASVPSGGAVAASGSGGGAAPAATAEEAKEEKKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G090</accession>
    <name>A0A8H5G090_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G090"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="263"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="47007" checksum="5DA7F9EC43E928C4" modified="2022-01-19" version="1">MPPQDDWSDSDDDAVSEMETSVLLGIPDGVIEATSDLDDAAVSRIGGYPAFLPSKEPPFPSSQCKVCSDPMELLVQLWCPFEDSPMDRALYIWGCSNSTCQRKDGSVRAWRGLRYNEKYAAKLEVKLAKKREREAKVTTTTNPFSIKSFQAPSNPFGLGTQIFGDAPEPKSEDTSAENVSDSESEASEQSLLTAMASTTLSDSIWRNGPSYPALYLSTTSEYIPPPPKAKVPTKDQVMDSAQDSGSGDMSWVSEAYENSLDVDNVFDRFSKRVGYEGEQCVRYDLKGIPLPFASDAVFDALFPAPAAPPLPVTKPDFKVVQTPKRSYAPSASVVPECRVCRGKRVFECQLMPNLINVLRDDKETKMTEEERKKAVEKALKGGSGKEMTWGTCMVFSCEKDCRLGDDGVETKDVWREEHVVVQWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5P6</accession>
    <name>A0A8H5G5P6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_008555</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5P6"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5358757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64255" checksum="0A8894A25935386B" modified="2022-01-19" version="1">MLTFSASVAFFAVLLTWIIWKLARIGQRESTLPPGPPTVALLGNVHLLPTQSIWMKLTEWAREYGDFYSLKLGSDTAIVLTSMKAVKELLDQQSGLTSDRPKSYFAETTFEGLHAATMSYNNTLRLFRKTMQPMLNSSGAIQHQPIQIAEATQLMHDLLHSPNMSLLLDLFMEILISLTNHQRVYTHLERYSTSVTTSIVFGKRFPEYDCAEVEGIFQSLNATARIFEPGAHPPVDQLPILNYIPDRWAKWKRMAKWGNRLVRRIYFHLLSVAEDRVRDGKENGSFLEGVIKRREEYGLTRREVAFLGGVLLEGGVHTTSLFLQWMILSLIAFPEVQKKAQEEMDRVIGQERAPRLEDFADLPYCRALVNELHRFRPVAPISIPHAMLDDGTYRNCFLLKGTTLFMNAWGIYHDPDVYENPEIFNPDRYLQNEFGAKPGVDVSDFRNNIIFGSGRRICPGIHVANTSLALNAMNLLWAFHFSPAIDSNTGKPVPVNILDLKNVSAVSFVNPNSKDLFLAPKSFSCSIKPRSVAHAAIIEEEFLAARTAFEKFESAPKELERVDEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Y0</accession>
    <name>A0A8H5G5Y0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Y0"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52563" checksum="FF5CCE19E077A5EF" modified="2022-01-19" version="1">MLAPKTIEGDNKQQSNAQSETAVPRRVLSSRKTDSPMIFLSCGYADGRGSLLTFMTARPDAEVVSFTEWLRQNHGEFDGRARFISVPSGFQVIADTEIPTDTTIVSCPFSLVITKKLAEEALLKLFNFPQAGLDSWSERQCIASYLGFHFILGEESREHLSHHPYVKMLPSHDRLRTALHFTLEERELFKGSNLYGAIIDRENEWRTEWVRCQEVISGVNEEWGQKFSWELYLASSTYISSRAFPSTLLSPNPSLQASPSAEPVLLPGVDSLNHARGKPVSWVVSYPNATTDIPEPRISLVLHTTTVPGDELFNNYGAKPNSELILGYGFSLSDNPDDTILLKVGGSGQDTRKWEVGRSGRGIEGLWLEIVSLMMQSQEPGSGPIYEDELEAASVLGDMARSLIDRLPPAKRNFDPAQIRPDVVKMYQDYIEGQHDILDAVVAFANEKERLAIERAREQGVELVIEDDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Z7</accession>
    <name>A0A8H5G7Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Z7"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5360059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="19203" checksum="7786F6CC17BA9DE5" modified="2022-01-19" version="1">MLKKVAEAEACPQEWDIAAWYSLAKRFDKHEQEDAIFCGAQRSGPPGPPKPTFPSRAQPQGCSLFPIQFPTPAAAPIPAPRAPAPAQAPLPQGIPMEVDALRQRFLARRTCYTCGKTSHFSAACPDCQREHVRIVDMSVDDWQEIAEAYVAFQDFQATLMNEPAQEDFAKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G884</accession>
    <name>A0A8H5G884_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G884"/>
    <dbReference type="OrthoDB" id="2756178at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="88"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="663" mass="75506" checksum="AD294937D9E0E756" modified="2022-01-19" version="1">MANPRTFLPPDMQQRLHVPQSRIPSLSSTRHLDPGVSPEQHPRSFLSNEGASYTMSWAEKVYEPDSSTRLWKEGDPYRYAPKRRGDPWEQCMKRVDNYDDEMSRGWKEDIDTLLVFAGLFSASSTAFLIESYHWLQDDPGDLTVQLLSQVTVLIANSTNQPIPSLNAHLFSDTPTAVRINTVWFLSLLLSLATVSLGILCKQWLREYRRDTPTSSPKETLELRQIRYESFEKWHIPILLSAMPLLLQLALVLFFAGVLDLLWSLNYIVASFCTAVVAASVFILVWTTVVPAYYLIKCPDMIFSDDVPLCPYKSPQAWLFYQLVLLLPFKKLKRRTYFANWAMGDLHILRNHFPSTQINARTHLLRGLRWMIALFSDSTAMASNIFHCLQSFSIEVAAIATGQSGETSKDVIFYNFFRNSSWDPDTGRFLAELFIRQLNGPSRTSGVGDALGSFWNLAYLNLIEDDPQNGLPNELLRQIIASVQNYIVDDRITLLDMSPLLMICQQLWKHPIQSVREHSTVLLDEFERWLTSAEGDIQLAFMPHLASALTEIIYAENDRSPISVLICSDRGPRFIRILNELMATRGIDMDGYSLQDMPMSWEDAKIKVVRLSGLSHEYFDVLKFPPTSPVQDAETEYDLQVDTATESFQQVPSVLSGDSMPKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD91</accession>
    <name>A0A8H5GD91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD91"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="36148" checksum="3FF766EEE10BD922" modified="2022-01-19" version="1">MKCLIHLIKLVASSLSWKLRTRPSQLPWPPSNHSWSLTEEGSLHDATTNADAEERRHKLNVNPSVSGVSIALTCLSTRTTKTSTNPRPVTLRLYYPSHNSLLPRPQIVSSPNMSQLPIFETPATPDNNLLDGNKTSSLLIPLAMSSRSAICHYLTNSSSAQSPAFFQLCPRRMRFPGASLAHSRLNYLPAAHQRGSSLYTLPNVPISLSPTEKPPSPTIDPASTIVTSETDVHSASFTEANTDGFNQESENAHSILANIQDFKSLQKTFSLLLKIICFLPWYILVSATSYYSLATSKLWLCPQLSDSSLPVLGVFIISPIELSVPLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDX6</accession>
    <name>A0A8H5GDX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDX6"/>
    <dbReference type="OrthoDB" id="3257623at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="207" mass="23150" checksum="0B4490A3F9BAD005" modified="2022-01-19" version="1">MAENHPNIIIVYMPGNCTGIFQPADVGLQHVLKHQLKQELFQHLVEQQRVQIKAGIKLEDASFNTKLGPLRDGTVGALVKAWEKSETKQYNLCDDCVCSAKSFKALNNYLKTHPKLYDEISLKTGTVEKADAEDDELYPDDTDIPLSAITQTALGMEIGADQIPFTSNALYVHFDSQDSWCDAWEEDLLSYNNDGSILPTSYLLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGY5</accession>
    <name>A0A8H5GGY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGY5"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31289" checksum="DE38B39FDD6D9804" modified="2022-01-19" version="1">MAPMNVLTLGASRNIGYFAAIRLLDAGCTVTFLLRDLSVFDADETIQKYVKARKAFLLKGDGLVQEDVKHAWEESASHGLEGKVDLLLFTVGGKPSIDIRRGAVIKPHNLVTQCFLNAVCTMPPPSKQPYPKVITISSTGLTRNSHAALPFLLKPLYGWLLDLPHQDKLGAERIVSHVCDMEWDPRDGPKENILPQGWQDFAGLPPKGSLRNNVLLVRPALLTDGECLADKNAKKGDKPPYRVKDVNDGEISGYTVSRKDVGHFVAQAVLEKWEAFGGKIVNIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIG9</accession>
    <name>A0A8H5GIG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIG9"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034740134" description="Fumarylacetoacetase-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="235" mass="25660" checksum="8F1D2155B502C4E2" modified="2022-01-19" version="1">MRILSSLSPLVLFSISASALRIVRFISDNGEIFHGDAILPANTTDASFSKTAKVIKGDIIGGNFTVTNEIRNINKLLSPLAPEATRSVRCVGFNYATHAEEANITIPDFPILFYKPWTALAPPNGKVPVTEGYQTQGNFTSTMDYEAELVVVIGKKAFNITEDEALDAVLGYAAGYDVSHRGWQIDRGGQPQPQFSMGKDADGWGPWGPALLTKDVIPDPQTLKIWQELVSYLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIH2</accession>
    <name>A0A8H5GIH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="347"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1307" mass="144426" checksum="3B8FA0970BC8456B" modified="2022-01-19" version="1">MSVQGSQGLQSLNTIIKRLEAATSRIEDIAAAGWKVNPQPTGSASTSHESAPAPPPPPPAPALQEVPKSVTAFDEAIIEGKLKPWLELTRSFAGPSVVEIAALVEKQYQEMRTLLATAAACTKPDEKTLETTLAPFNATIEAISHTKEANRKDRDWFTHLMVIAEYAPFVAWVLQSKPGPYINEVKDQTLYYGNRVLKEYKEKDARHAEWVRSLTATLDELRKYVMEYHTTGLTWNPRGVSVATYKSSAPSAPAAGSPPPPPPPPPPPAAMPPPPAGNAAAGGTAAVFAELNRGDEVTKNLRKVDRSQMTHKNPELRTGSTVPSSSGPGNKRPLKPAKPQALMGKKPAKFALEGKSWVIEYQEEERNLVVEDTQLNQAINIFGCKNSTIQIKGKINAVTLVNCSKTSVLVDSVVSSISITKSPSFAIQITGSAPMIQIDSTDSGQIYLSKNSLNAEITTAKCSSINISLPVEGEEDGVFEEQPVPEMLRTVVNNGKLMTTVVEHVGYASGVTRSFENKPSQIVTPFYLYPFEQVPFYILKDSELIKNQRVTQENDYFQTPHRGMDGRFMPVEQVTPMEEQFIGGFHPGLPPPSPAPPELPPKDMPVGYGQAIQPTMSNVELTKLSAVERSRALQVARMTPHLQFMVGPLLRYDTIDANGVWHGAALVVTADSGSSYDPSPCTLLEWDPEKRTPSNKRAKSIRRPHAQSFDLGPHPADPHSTSVIIANQLNGRPSQSHSPSAQVQNIIGEELYVHAGNGGTFTFWRFPFHIPLGPNEMVITYSINKGQKMQFFVPGRSQNMRWAAHSCNGFSAGVNPDDFRGSGFSSGYDPCWMDLLSKHAEEPFHAMVGGGDQIYCDGLTREPELQEWVSKLKPEEKKSYPLTDEVSEAIDRYYFSHYCSSFRNGAFARANSSIPMMNMCDDHGMSSVWLLSVAILISGQILYFFLFSFDVLIVLIDLICWLTRLMALVAVHPDDLQLSPVFKAIGSKGYFWFLLFQCFINTEVDGLDDRRHINKSIIIGLQGPYMPFPSHSFLGSLGPQTAILLLDCRAERKKDQVCSPGQYQKVFERLNELSPTVEHLIVQLGVPIAYPRMVFLESMLESKLNPLVALGRNGALGLSGFVNKFNADAELLDDLNDHWTARAHKKERNWFIEQLQKVAEAKRLRISFLSGDVHCGAVGLFKTLKEKNQPEVPPAQDPRYMVNVVTSAIVNTPPPAGVITMVSSLASKTHKTLHHIKTDEIMMPVFQTETDGSSRKQKFIMGRRNWCQVSWDEGSGDLIFDLRVEKEKGAGTSVGYVTRVPPPRWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ32</accession>
    <name>A0A8H5GJ32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_003127</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ32"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000156">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="534"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5365696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="867" mass="96986" checksum="F6A129905C8556B2" modified="2022-01-19" version="1">MCNKANVTCILSTATTYPGMSSPAAPGNKIRVTVVAADGLSKRDVFRLPDPFAVITVDAEQTHTTSVMKKTLNPYWNESFDIFVKDSSVVAVQIFDQRKFKRRDQGFLGVVNVRVSDTLDLELGGHEMLTLDLKKSNDNLVVHGKLIIYLSTNISQPITNPGPSQVSGLNTAFADMGLSNTGSPGDSNSNLPLPNSTSLSRTSSSHATTTTDSTATSPSVPSSEVEQSSSQTSTQSSSRPTSATGASLTSSNPPIIGAPPSATNPSANAQQMRNFNPNVDQYGPLPAGWERRIDPLGRTYYVDHNTRSTTWNRPSSNATANTNAQDNETNAARDQHSRRILADDLLEANNSSSVNRSSTATPPTINANNNGTAAAAAANNTTTPGAGPLPNGWEERFTLEGRPYYVDHNTRTTTWVDPRRQAIVRVMGPNGQASSLQPQAISQLGPLPSGWEMRLTSTARVYFVDHNTKTTTWDDPRLPSTLDANVPQYKRDFRRKLIYFRSQPAMRAQPGNCQIKIRRNHIFEDSYAEIMRQTPNDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPASGVNPEHLNYFKFIGRCLGLGIFHRRFLDAYFIVSFYKMILKKKVTLADLESVDVELHRGMTWMLENDITDIIDETFTTTEERFGEMVTIELKPGGADEPVTEENKKEYVDNIVEYRISKRVKEQFDAFMSGFSELIPQDLITVFDERELELLIGGMSEIDVDDWTKFTDYRGYEMNDEVIQWFWKCVRSWPPERKSRLLQFATGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPSQLPKSHTCFNRIDLPPYKDYESLEQKLTLAVEETVGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK48</accession>
    <name>A0A8H5GK48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK48"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65881" checksum="0AFFD7D36452E661" modified="2022-01-19" version="1">MRIRPYSFLFPPMSNSLTVRYLHYEELGLRKIVVHINATCNDLLQAIASDAYPKPHSAALTIWRPQTPLSGLATPNELRVRFKTSKPVEQTCTRIDLTMFVRDLLESKYESPQDDCVPIVSFSGRVSIAEVSESPGLLVSAFHQSVLRVEKERPPRPCACAQSRPGGDTNGRDLSMVTTPVELYHPAFLHFLQDVETNALSPSPEILADTVGLMTSIIANSSSPSQKESAMDQLLAVLGISRGFVPNGSDPTPSPSSVILYPSTPRKAALAAIVIEGLKFGSSNDPTAEVFYVYKKLWAQPERRRWMESSSSPTFLIALTGSWLCIYGAIWTTKPIIQRLTDMMWLGVSPLLNENKLSRIAGTLSSARQGIDTLKHFYEDLELGSPSLNDKHPRFYPSVTTYPCPRRPGKHIEFEYVEPMEKETHICVTYRARTTPSPYADEGTALETLLSKLFYRGPLSPNSELSMVVMDYFPSETLTSISLSMEICDEVYLGVKKALDVLHEAGFVFGDLRRSNVLVQRGGGYEGAIEGESGEVKVVLVNFARAGRAGIARYPAFLTSMMLYPEGAGPWKEIRKEHDDWMLESLRRPVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKM4</accession>
    <name>A0A8H5GKM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKM4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="67" mass="7422" checksum="EDF1DB4B3F232F72" modified="2022-01-19" version="1">MSTMSSPVPGVANLSITSSPPKAHSVSEQDLEDPEPSPQNIAKCRNVDWILKHEPFSVYKFPEELMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL57</accession>
    <name>A0A8H5GL57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL57"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="121" mass="13714" checksum="5E7EDF244E973BCD" modified="2022-01-19" version="1">MENNPDAKVYNISGLASNTPNHIIRQSLKKIVADSGVRNRRSNAHIPASMAKENKLKLKRSMKKAQAQGKELSSFTRSLGQVFLQTEKEREKQKLAMIAVQKRQEMDVSRYKTRQAACSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNG5</accession>
    <name>A0A8H5GNG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_004446</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNG5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5367975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40779" checksum="180A8EA92A4B5C83" modified="2022-01-19" version="1">MGIGTRMGRMKEKAALRENSFDTNHRHRLTKTEASWLSVRMFVAGADTTANTMAWLLIILAKYRDVQAKAEIHAYLASTSISTPTSTNASASASLSSPPRPRLPTPTDHPNLPYCRAVLRESMRWRPVDPLGLPHMCVEDDVYVCADAESGGDEDVQFESEPEPESTGMRNGNGNGEKENGTAIRNGEKGREKEKTQTRTGTVGPSKPQPKQKAKTYLIKKGTILLPNVWVMNRDVEVYGEDAGEFRPERFLERERVAVDQDSESPEGGGGGGGGIKWKWKLVSGVRDPSKRDKEEYACLREDGMVNFGFGRRICVGRHLTMSSILFNMVVILWAWDVLPPRNGNGDGEEYVEPKLGIDDEVRDGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPJ9</accession>
    <name>A0A8H5GPJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPJ9"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="628" mass="71533" checksum="9F4220E92A32CC85" modified="2022-01-19" version="1">MGLTRVSQRICFLLPSLNHAPCKHHNLATSEEVTFQDMQNRQVTERKAGYAKLLGACVHARKYNFEWIWIDSCCINKESSMELSAEAINSMYGYYGDSEVCYVYLADASSAEDPRDVQSGFRTSRWFKRGWTLQELLAPRYIVFLGKDWEEIGTRWSLWDAISALTRIPSRVFKYGDMTRYSIAQKMSWAAFRETTRPEDQAYCLMGLFGVNMAPLYGEGSVKAFMCLQQEIIKVSDDRSIFAWTARTGEKGTRGLFAKSPFEFRMSGEVAASETDTIDEKSSYTFANNGLHIHLPLEEVSDLPVDDSHNDDVNDDQGLFLASLHCQFKKDDSYLSIYLRKINGQQYIHCHADKLGLTSAPPAPNSLQDLVVKENNHIPSFTRRQERDAEELVVSVKLSGTVTRNRLVYNGSPDIEGLSTFSVKKRGSLSLKYGVRGTSSTLQTRFVLKLLHAQGNLLSLKVADGYHYPRRGLSDYFDWEHPELADTIVHPSWNGDLVSFRYQNTGKCTEKIIEMIYLSQGDALTALKRELTPPAGDFIVPTEPSEFDYYSASLQRISSLDFLGMDCGPDRKYLSFQASTFRILTYTASWRRTHSFLLDFEELYRGCIYLFVGKSLRLRVRNGIWPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQR0</accession>
    <name>A0A8H5GQR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQR0"/>
    <dbReference type="OrthoDB" id="3052556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="783" mass="88118" checksum="7A1D0B375DAF1822" modified="2022-01-19" version="1">MTVGEASGGDYRQLEADFQYIEEKLTEISKQHRLLLVLFKNANEEAVKKCLKKLDGSLDNFALARQVHNATDLKKLENDIETYYRTLQATWKNTEEMRGNIEDIKTILRNFNPEFRQEIQSTTRKLRPPSRSHIFYGRDELLNRLATRLVPALCETGSKVLLALLGPGGIGETSAALAVMEHDFVQERYGGSNQFWVGCAKATSATLLLDILYDSLCINKKTGQTLEDILAELEPPSGKPEQQPYRLLLLDNFETPWTDEGQPVDAEASAKIYTKIYPQTSEEQLCELLDAIGHLPLAITLLANYARTSQVTLVELLRDWQRDGPDILSISDDGEDNVMHKSIKFSLDNPPMKKSTYAMKLLTLLALFPTPVSHVDLKRCWVPEGINQSKALHVLSKTALVELTEPTAFVIPVIRSYILHHTPDRDFADTRFHIHRVCCSLIADHGSSPGDPTYLADKQFLSSQEVHLQSILLDATSESSADVSPEILQALLTLSWHQCYTRPRFDLVKHTLSVSKRMKNAKYEAESLVCYAEMCFVLSQYDGATERVSLAHDLFIALGDRISAARCSIKLIKYNLYNQTSSLEEHLSLVEQAQTAYSANDPFGQALCDLWLGGTYNCHGMPLQARAKLEQVKAKFEEPGRRLELERCIEALAFSYHVSYSLHPKLVPNSLTIALHLANQALELSIQCGREEYQSHSLWNLTRILKDSGLYDETLGRTLESLKLAKSLGDYVGAQNALQKALVAFEEMPASSLKDYLIRDCRMLLNRVETTPNSMESVDRATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS28</accession>
    <name>A0A8H5GS28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS28"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="8">
        <location>
            <begin position="419"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="513" mass="56467" checksum="A1681AE229BACE2D" modified="2022-01-19" version="1">MFCESVNYEEGTVTFRNGVTVRADLIIGADGIRSAVRKAIGVVPDITSAPQTCYRCNVKRSDVDKLGLVKYSYEPAIQFWGGMAGSNGRSKYYKIVMSPCSDAEVVSFYCFMPTELTKHHEEGFVFAEVPVSDIIAGKYDELDPDCVNLLKHSVDRMPWRLYVHKPYTVRYIFLIFHISDSAHPMMPHQSQGACQAIEDAAALGIIFSDKYGFTQDVSAGLAMYETIRKPRATRVQSASARATENLNERIGFTSLTPHDASLAAAEGKLTINEMNSYKMHDHVASEVAKPTLSGTMGAKKNRDKKAAATEPAPEAPAPEAEGPPQSEPKPPVEVLYCAVCSFPPEYCEFGSSLTKCKEWLEEKHPLIFQKYYSDEALQSKIGTMSLEAQSKLEKEAAKKEAKAEAKADAALKKKMASQVTIKRIERNKRKHVTAIHGLEAFGVDLKKAAKQFASKFATGASVTKNLQGQDEIVIQGDVSDEVLEMIEEEAGILKGIPADNVEIVEDKKKKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS40</accession>
    <name>A0A8H5GS40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS40"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="275" mass="30505" checksum="9FBF527952AFD7C5" modified="2022-01-19" version="1">MQTTQSPTIIPSVYNATTTYTPTTSLTTPLTYYPPFTHTLDQTTVEPPRPPSPPQPAVTPEVASQAIQRLISSEFRDANFESAQPSALYRLEQEVVSFVQQLYQRAHAYANLSNRATPIATDVLLAAEEFGLSLSELRSVKSKVAKKRKKAIEPIHAPDLVAPESRPSSPDLLPSDDETVPATVPTTLRTLPAHFPSLPPKHTYLQTPASPPKKAAIPSLDKKLKTASLVQDSLKNLLLATEERTNQDDAELWGHTVNWETSVYPRKRWRVEVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSI0</accession>
    <name>A0A8H5GSI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="256"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="836"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="874"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="917"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="960"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1131"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1303"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1346"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1389"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1502" mass="166672" checksum="09483BA686B2B492" modified="2022-01-19" version="1">MDSKEKAMTKVKKAARRFFGSNPGTPTSNTPVPNIPPQSALHALADSALKTATNPAQKVSVPVPDNASVPSPQSAMKGEVALDVVEKGLVILDVASEWFGPLKAVTGVLGECIKTYKQVMDNKKDLDKLKNDLTEEVQDLQKQRKKYESSEMEQIFGDLLKELETVSNETVRRLQASNLQQAIQSVRISQEVEQFFKDVSKAYENCKFKVSLISARQTSEILKSLNFDKLKLSMKAFHDAQIGGGKERDSCTPGTRTQIIKDIEEWAERTTDGNMAHWIYGMAGTGKSTIARSVCLSLEKKQLLAATFFCSRQIPECNDCNYIIPTIAYQLAQYSPAFAEVLNKTIQEDPTIISKSASMQLDKLVVTCWDTVFKSQKLGPLTPVVVIDALDECRDISSVLEVLIPAIQKQELLGLKFLFTSRPEYYMHKYLKIDGPLSEGSNVDRMFLHDVEESLVQADIIRFLTCQFEHSELSVSEHNINKLANMSGKLFIFAATIVKFILEKHNPIMAEKRMNRVLDLKSKQEKHQTKGLDELYDTVLEHSFDFEKSLSEEKDTYLMILHAVITVQKPVSPSVISKMLGLQLQEVEEVIRELYSVLYIADSDQAIYTLHASFPDYIRTKGRAKGAFWCNEGLYHTILGKACFKNMMEELKFNICQLPSSFLADKDVPGISDKLRAIDETLRYSCRYWPYHFIWSDMTEEVIKQWKGCMEKKSLFWIEVMNLLGSIPEAYDGLQFLLEASDFFLDSKSSQTDFLQTMNNKENKTEIQAKIQAKIAELQQFLAFHAKSPGVERTPHLYLSSLPFWQKDFLGKQNLQNIINLKKCFQQSREMECWPTSSLEAVAISQDGKLIASGDWNGIITIWNVLRGKEVRRINGHSDHLWSVAFSPDGTKIVSGSDDKTVKIWDASTGAQIGEPLQGHSARVMSVAFSPDGTKIVSGSDDGTGRIWNVATGSQIGEPFQDHSNQVRSGGFSPDGTKIVFGSGHTVRIWDVTTGAEIGERLQGHSKQVMSVAFSPDGTKIVSGSYDQTVRIWDAATGAQIGEQLQGHTHQVNSVAFSPDGTHIVSGSNDETAIIWDMVTGSQIRELLQGHSNWVRSVAFSPDGTKIVSGSHDQTVRIWDAATGPHVSEPLQGHSNIVYSVTFSPDGTKIVSGSQDKTVRIWDAATGAQIREPLQGHTDEVNSVAFSPDGIHIVSGSDDQTVRIWDMATGSQIGEPLQGHTDRVWSVAFSPDGTKIVSGSADKTVRIWDAARASQIGEPLQGHRDWVRSVAFSPDGTKIVSGSNDNTVRIWNAVTGAQIGEPLLGHSDNVISVAFSPDGTKIVSGSSDWTVRIWNVATGAQIGESLQGHSDWVRSVAFSPDGTKIVSGSDDNTVRIWDAATGAQIGEPLQGHSHWVMSVAFSPDGGRIVSGSFDKTIRVWEVHADDNSLVAQTDINKLWTLDDDGWVHFPNISPGIVWIPPQFRPLLWRPQNTLIISRKGYTMIDLSKCIYGEDWTQCWPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTG4</accession>
    <name>A0A8H5GTG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicle transport protein GOT1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTG4"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15287" checksum="0F769B187D7452FC" modified="2022-01-19" version="1">MWLTDAQKIGVALTTFGALFMLLGVMLFFDGALLALGNILFVSGLTLIIGPQKTFYFFARKQKIRGTLCFLGGILLVFLKWPFFGMIIETFGFLNLFGDFFPVVITFMRQLPFIGTVLSLPYVAPVVDRLAGSRTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTT7</accession>
    <name>A0A8H5GTT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTT7"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="505" mass="55987" checksum="B9857E8CF988181D" modified="2022-01-19" version="1">MEEAEPEGQINGKTRAKKGKSKRKADAAPKPGLFRTTKVKTRGDPRISTDEEDPMSEEEEHHLIPSPSKISKTPTVEITTSPGNGKNSPKRTVSVVMPGLKVGSSTPSPKKTNVVTRNESIHVASLERRRPGTSTRPGPSTGAADSSPMSVASATSRVSKRAAATRASQRLHEEIMPDVLNFQQEMKRKGKGRESLVFDSKRRRSSTAVTEPEEDEEDVSEISRPTKREKAAVGQGPKGSRKTEKQSASSRDGPAAKKRKSAADELSDLSDSDMEKNKPSERPQKKRKMAIEKSGESSAASKTVRLMTTQLKLEQDEIDSLKSMGVKMTTKWSECTHLVVPQLVRTEKFLCALARSPYILTIKWVHDSISAGKLLSEDRYFLKDEVNEKKHGFRLVDSLARAKQNKGALFKDKRFYITGKVDVDYGLLKHVVEANGGQVSNQQPTLRILDNDSDNRFVISCPKDASIWRPLAEKYTIYTSELILTAALKHEIEWDNDAFRVSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVA2</accession>
    <name>A0A8H5GVA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVA2"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5371697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="520" mass="57379" checksum="F883E26651DEE2CC" modified="2022-01-19" version="1">MTLERQFFTCLPLVVLFPQFFPRKQNLCSKMMNERKEKEKVQPSLVSQSNNGLGLRVALGRLVRLIPFFVLYFARENLKLMLDGLPSDQSFKSINLVFFATSAIVIPISTGFWSRLGDKLGSRSTVLVTILLCLTLFDLVTIGVLAFSSVPQNHSMIWLVVVRFCEGLLGGAATVHSLTLAYAADVSSPNQRALMFTLLLGFSLLAAFIGQMLSALLFNLSNLLFASSCVVILSVLNITYVLSFLSLPITSNNSRERASCNFHGLKDFLKTAFSFFTVLAPGVAFERGRMTLLGVALFAHSLTMYDATLKIVSVYFPHYLNKMGWFVLFLWILEMVSLVIILPIIIYRYRSTRMSSSSPITANRTLAALLAFGTTALDLLGFIPSSDQLMFILFGILFPGIFSVGIPPLLLAIGTLYIDQPVGQDTGNGSVGFVLGGLVGLQHLGQVISLQLYYLLNQTWDHVPKETYLFTPALLGTAGALLLFSRKWDVADVSRDEWGVVHSELGDEETSALAPSRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWF5</accession>
    <name>A0A8H5GWF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWF5"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="291" mass="31225" checksum="29E243892F41D5A6" modified="2022-01-19" version="1">MKVLILGATGYIGFPVAQALCRAGHIVYGQTRSEEKAPKLAAEEIYPIIGEPNSSAWHHLVPTLDVIIQAIGGRNPEISKEIFQSIVSLSSDTSLRPPGSPKLTFIYTSGIAVHGAYRDEIISDTTPIVVAKSGELAKGHAAQEQAVRENQVFNGIVIRPGFVFGRSMEGSAFGPMLFAQAKAGKGGGKVSFPGKPGGHLPVVHQDDLADLYVRVAEKALLIGGLALDGVNDITESTEGVLQRFIEVSGMKGPVEYREPQHMFDVAPRKIGFADGMHLYYNAYLANTQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWN2</accession>
    <name>A0A8H5GWN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWN2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="29056" checksum="AE67383EA5FC03EC" modified="2022-01-19" version="1">MHSTVTTTTTNMIRSSSKMAARKFQPSLPVMSRNKSSSFKGMKEACATELAELRRTASRLSGVIRTLSSTGTPKNLKSPIVADAAFEDKPGLSAQVVPSTPVVATKPKPVNTTPRPGDRCEEKKVIYMTNSDIMKIQASRANDIAELKASFAQSYTNFGAGSKTKTKPTPFAGFASVSTSPPAVIDASKSPSSKPMTVWTDAIEFFSKENVNLVNSYSRVTNVVDERPSDIIIEADPGRVRPRYHVSSDKKVHQRHMEAFWCGGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWX6</accession>
    <name>A0A8H5GWX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWX6"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="417"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="417"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="481" mass="53680" checksum="4D371AAE5262E0A2" modified="2022-01-19" version="1">MEDRRAQTLQALSAFIQTQKALLTRTQNDIERLKELRSKAVAQPSEILGDLEEEVRSRRSRRHGRLTKFLPQLDNSAYRLSEQGDCYPQVPKDISWSLYANHDPAPFHNLHTQHIPPQPPFTPKSTISDVQQYVKNAKASILEPVFAKLDLSFDPPPPEPTEDPKSEPSEAPDSTAIKKRTKERIKEQRKLKNISCVTISGNGPSRGRGGLFIRKDKNQDLLNENNMAVDIEPQQSPSPQTPITPYSVTSTLPPASPCVTPIIPMALSKTSRVRRRTIKASDPYKKSSAVPSHQSTPTLVSTRTRRQSRSSQVDNEDMQMDTRMDVDPPVIIQSHSPVGSVGDAHPHDADDSMSIAFSEASTYASASSASASASTRRSPTPTVELPKPKPRGPVIIIPSKNDRLALAANGAVPGRLKPETYKQAWTSEEQHLLEKLLEEIPEGEKNRWKKISHAMNGRRTPRQVASRVQKYFEKLKRFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX43</accession>
    <name>A0A8H5GX43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX43"/>
    <dbReference type="OrthoDB" id="2652955at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="514" mass="56815" checksum="438CEEBD11CDCB2F" modified="2022-01-19" version="1">MSISKLTGLAVLANEHVIKGKTLLFDANFYVSSGETIVTALQYFNGDDHKFDPVAKYELRAHVACMPERIQMSDEIFLEDTEYDLVGDIIWLHCVNVNDPKQRPYLDVISVAQNVVWGDAEFDLTAEEYINPIGKASLPVCAVIPDLPKKDSSSSKPIPNKNSSIEVSGSLTCVIPHENDLEEHAEQFFIAVDSAAFLQRSSGSKSSNKSPMQIQTQKGKQKKVFDFNTNQVAGAISNTDEEDGASPDKKQKTPGKAKETEPADNSKVKQKVEHSTGTGSRKIDHGLQLVFDTYREESDYGEMALLDFYKAGLPKDLWKSVGQTWLKWKDFDEYRDRAMDLHLEWLNEREKEGCWKPSSTLRMNSGPSQGWTVASVNVLMTSGAQSSFTPLPKLTPEERDRLCKLGACFACGQPGHMSNECPTFLNNTPRLSISQNTSHNFPPCAVRKADTSTSTLSSSSSSSPPVTVAQMSSSSQNIIKDIPDMVNKVKGLGGEEKEQASVYLKDVVAKMMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ53</accession>
    <name>A0A8H5GZ53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ53"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="289" mass="32620" checksum="E3BD2139FE669606" modified="2022-01-19" version="1">MGRLAEMQRKLLEQMMGPEAMGVANANLTWNDEKVCRNFLCGTCPHTLFTNTKMDLGACPKSHTERLKQEFLAAREANPIDPVFNRFQMEYESNIFAFVDECDRRIRAAHRRLEKTPEENAKTTNLMREIAEIELAIQGGTDKIETLGEQGKVDESMREMAAIEALKSEKADKERELQQLTDTSGASGHQKLRVCDVCGAYLSVLDSDRRLADHFGGKMHLGYHELRNMLAKFKEDREKRKAAPAPPGSGGGGTAAGGAPSRSSEYSSRNEYRDREHRNYDRHSSSRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H167</accession>
    <name>A0A8H5H167_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H167"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="367" mass="40633" checksum="51976F440CA62253" modified="2022-01-19" version="1">MASYSEDEFDAIIEAIGDAEWNALTSQIPGGSGPGRDLERPRADQALSQHEEFEEGSSSPSSRSSETAATNSTHSAPVMRRSPSESSSAYFSEDEDDMDSLFLEQLDRLEREVLDAMEASSQPPHEQSHIPSETTNNHSHTHDSHSHPQRYTPHHNNPDPKPKPLPLLSTVNPVTSSPKRPRSCSDSSDDGVLLNKKGKTKAIGDIEELMEGFLEEVTCPICFDVLVGASLINPCGHTLCGPCGYAWVTLKKQTTCPVCRAKCCHFKPLISNIMVDNMIEKHIEIQAARGDVDWAIGGVKWKERHERLEKWKKNVNYTRGVPRRLPVNMLPTEPPANVVDPDILFGIRAMHSANDYGPRSIFDIFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1B6</accession>
    <name>A0A8H5H1B6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1B6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="42834" checksum="60B1E544FE217D2F" modified="2022-01-19" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H204</accession>
    <name>A0A8H5H204_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial presequence protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H204"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119541" checksum="A4D03A84245567A7" modified="2022-01-19" version="1">MLSSISRSSRFLRLPLRPLSSSHLSVPYRSFASTITTNPVMSSPRESFANFDLIKRVKLDFTDVTISKWKSRVTGLSVVHLDYEAPIVSGYFVVATEIFDDSGCPHTLEHLVFMGSEKYPYKGIIDHFANRGFSNGTNAWTDTDHTAYTVATAGEQGFLQILPIYVDHILYPTINKAGFITEVHHIDGKGHDSGVVYSEMQGRENTSGDLMALRQQRLLDPPGSAYRSETGGLMEALRVLTAEQIRKYHGSYYVPHNLSLIVAGKLSSGTSSLLSVIQDQVEPSLIKHGQNLGARPPGWKRPFVETPSANRQPIPKTIKDTVEFPEKDESVGELIITFLGPAPNEFLERKALDILGTYLTSSAVAPLNKEYVETESPLCTYIYFSEDTRATRVSLPIYIGSVPTAHLDTFDEKLKDSLKTDERQLRSKLESAKGDTFSGTVITDFLYGAEDGSELGPSMDEINQYAAVRKWTSKQWTDLLQKYYIDPPSVIVVGRPSEALAEKLEADEKQRISAQVKQLGEEGLKKAQQELDEAKDENDKPIPTEILTKFHIPSVSSISWIPVQSVQQKGEGRAVNGVASKSAVSSSALTERINADGKELPFFVQYDHVESDFVTIHGFFSLENLPERLKRHISTYLSALFSLPVKTSSGQHLSHEEVINKLDDETVSYEVGLGVANSFSEMLRVSIKVETAAYETAVAWLKDIVYGSEFTKERLSVTIAKIQQSLPELKRDGNTVLGSLWADLLHSESSTSRAGGVLPQVEFMPKLAKQLQEDPEQVLADFEEIRKHVTNPAGIRFSVTGNVMKVANPRSTWGKYFNFIEPVSLSPVPFASEYLSRVGQEPVKKAVVMSLPTIESSYVTHTTKGIKGFDHPLYPAFRVALEVLNATESYLWRYIRGSGLAYGASVHLDLEAGLLSFSLYRSSNSMSAFEEASTVLKGLADGSIALEDTTLDAAKSGIVYMVTKAVSTAGRAAQASFNNQALKDVPQNHQVDLLEKFQAVTKEEVLDIIRKYFLNLFDSNSSVGLVVTAPSKADGIESGLKGYGYEVERRTLEVDPSELEGSEYDSESGSEFESDSELESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LFY1</accession>
    <name>A0A8H5LFY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LFY1"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5356422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="36073" checksum="C6BCF6A5F622C4CF" modified="2022-01-19" version="1">MPSASTSSPQAISSDQLDAMKDAQDILLEGIVRDDDEIAELSQGDPEEVILYYPWEGVDGVQLYRQDFRQLEPPGWLDDSLIEIGLKLFQIRLEEANPELAEQIHIFTPFFYPILSKNTDNLEEGYRHVRGWTDADKVDIFRKKYLVVPINRSFHWYLAIIYHPEYALDDSTEERRCVLTSYPVDRQTTVMTDRASIWTLDPLGFDRPEVVDTLAFYLKAEAREKHGVSISDQKLVGRKALTPTQPNWYDCGPYILVFAKAFMTSPDDFLESISGNKAESFWVAEEFQAIRNFLKAEINKFSKQWTAWKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LH93</accession>
    <name>A0A8H5LH93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LH93"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5357366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24716" checksum="72A95E85C7A8D9B7" modified="2022-01-19" version="1">MKEQHKPLRAYRTISFITLFLLLAAFLLLLLVGLSLTIIKPIYIMELTATSRGQPATSLFTRARFGVWGLCLTSVLDTNDRLCFGPRLGYNDVIPDQLISLIGISPSTIRTALQGLFVVLILHLVAAGTSLLSLFFSLFLASHAATIISLIFTIITSLLASVVFAVDLVIAITARDRIPDLTNNGFTVNTGNAVWMVLGAVIASWLAVIFLSARACYCCGVRRKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHE5</accession>
    <name>A0A8H5LHE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHE5"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="460" mass="49555" checksum="6CADFA01882FB29C" modified="2022-01-19" version="1">MHTRRSENSVVEPDLPRLPRILDPRLALSSLQYHLPCCVYLNMSINDPAGVSALLERLRSSQAWRDAIGTSITSNTTTAQLPATSSTVPPGPTPQIQDQDENITSDDLTPETSPAPPSTVDTPVGSGRGIGDASPSSDSQFSSTLPSPSGASASSSTSVSIASLLSQLQPVPTQAGQDSELGSSLPLASSRIDRDRHHAHTRTPANAHAPTLPNTHTNPNPNPNPNLTPNHFNHQHSGPGGVNYTIPTQSASSSSVSSSSPSLNIENDIGIWQWSSSDGQTQSAIQSHTHSKSQFQFHDTHASEVLLQGPVPVATPQVADRRRFTFQQALPVVAKLSEDEAFIKALASMKKEQEKLEHRLWEERGAIIRKYEDKVKTAVTKATITGGTGISKHEAAMLTDACKKELRRFDSERALVAWDGLITQQQEHLARLGVPTMFVTDVAADRETQQKVTQVLEGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIN8</accession>
    <name>A0A8H5LIN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIN8"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034303097" description="Glycoside hydrolase family 71 protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52550" checksum="1233087C3B46FB77" modified="2022-01-19" version="1">MRASLLHLFGLLLGAVASVVSLPNNATDLSSRQAATNKLVFCHFMIGIVSNRNSAADFDDDMKRAKALGIDAFALNIGTDPFTDTQLEFAYASAANNGMKVFISFDFNWWNTGQTAEIASKITHYGALPAQLRVDNNKIFVSSFAGDGLNVAALRSAVGQDIYFAPNFHPGQSDFGAPAGGNLVTVHAGDQSYVNTLAGKGYIAPASPWFSTHFGPEVSYSKNWVFPGDLLWYQRWHDILTLQPRFVEIVTWNDYGESHYIGPLSSPHTDDGSSKWVNDMPHKGWLDMAKPFIAAYKAGSPSVDPFITSDQLIYWYRITPKDLNCDATDTTMVPANNASGNYFEGRPNGFEAMTDDVFVVSLLTSPGTVTVNSGAQKYTFDAPSGASAFAVPFRIGAQSFALSRGGNQVIGATSLKVIQDTCPCGLYKFNPYVGTVPESDRDALQGASLSSFTNGLKVAYNPAPSLPASPPATTAATATSSATAAPITVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJK5</accession>
    <name>A0A8H5LJK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJK5"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5359900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75833" checksum="7722FA5778766670" modified="2022-01-19" version="1">MVSWGFLFVTGDLIRLSERGKEILEEALPSRNPQDLLIQKNWDHFVTTVRRPIPRLPTELILLVVSHCETFLCLKAGRLMCRSWYEPMSEELYQCAMCKLTWSALPRLDGFDGTRQHNHFTRMEYLSVTFPLCICPIHNHPNLTFTRLVFLELSGFANFAETVDLTGRVRFENLSHLSLQHLSGPLPAWIQLIQGVNPRKLKKLTGDLCIVHSFKPEDFPPVAPSPFEFNDLVLTLNYAWGLFHVLQHFLTSGISSLAFTQNGVPGDEIITFLNRQAPSLKLLAWHAFIDNALKIEFSAMRELQHLSMHGTEFRPWVTLPVKLKAVSRLMAHTPEMTEYQFLDDALSSLVEWRPLQRLTIFPSCSLDVMELETSELEEFLPKTFHIGADKELFQFTSFLDAKTFPSAHAMRQANIIRKSLSTMESLGAVNFICSDETGTLTQNRMSAVNIGLQVPLQNLPIEQAMVEISKGDEEDIKALAAAAGLCNDAAFEGSNKESALETRNINGDATDSGLLRVSDYLSALQTNFVVKLFKWDTAKLPLPPSSREQFSHDILLLVKGAPDVLLPRCSYMLNPDGSMVSLSPSNISEIIAAQEEFASQGQRVLLIARRILPPGAITSVELVDLARIEDKIKTSTMELAIMGLVSLMDPLKEEAAETVRVELVFGFPWLQVISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJW5</accession>
    <name>A0A8H5LJW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJW5"/>
    <dbReference type="OrthoDB" id="3022054at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5359902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="588" mass="65865" checksum="F7E450C079FEEF66" modified="2022-01-19" version="1">MWPFNTSYQHILSLSGPKAGIQSLAFSPDGLFVSAVGYGRVTIWELQSGTPVLVPNVTYERFDPQHAYSASAWLYFKGTQKHVLTYANINGELIIRVWDSVQKQTFPEKVCQTVDCDQHKEVLSIDVSTRSVSPGSHGLIVTSTTNGVVAVWMLMANLELQNVFMADLPQEILPHTVKFSSTGQIYAFSRMGGSLLQLNGETGELMWANNKGPKAMYSVSIHEKQDLFGAWIGGNAALFKLSNSEFVRDFKGVDTLYDNAKEVAFAEEGSLIVVGSDHGPVQIFSVSSGQLLQQLEFHHLAALQYVAAQSLPNAHLIATASSTRDKPADVAVYQKKRCALKTLSQVKDDANLAFHVRITWNAIRWIGFAIIMLIALYFALFHYCHAFIFTVEASVFPLGFGWRRFIYVLALSRYSNLHYNMPVTQTIITPTESLTEYVTDYCTEFLTNAITERITDFVAEHHTEFLTDFITECITKFVAEHHTKFLTDFVTEHLTDFVTEYCTLTDVVTNQVTNFVTEYRTLTDVVTDHLSDLVTEYHTLTDVVTTIEVYTVAKKIVHMFGTFGKIADVRAIEQKSQNMAGGSKKAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL95</accession>
    <name>A0A8H5LL95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL95"/>
    <dbReference type="OrthoDB" id="2560085at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="201" mass="21898" checksum="D5C98A1C52EE18B3" modified="2022-01-19" version="1">MSTSSVSTPMRGPRLVALFMSFAWGVIALAVAISAQVKSDDSEDSLKRLVPQGTTLTINSGDVRSSGTVIAVVSGIIALLSFIYIVLILFFSNLATRSLPIQWASLAFLAVWLFATQIPFTVFFANREAQVTIVANGVTLPSVLVNQLEQSLGVTPVYRHIDYLRLVAVLPWITFLFTVIGAVVSFSASRRRKSFVRNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMB8</accession>
    <name>A0A8H5LMB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMB8"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="83"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="43427" checksum="FF678D3B9A615D64" modified="2022-01-19" version="1">MSPQPSTSTTTKSSRKTGSDKKTLKPAQRAKTKVSWLHWQWQLISLVALVAGLLVYYYQSSAESTQPQPYASTQFQSPEERDASIFTVQDLRGKGKGMIAIRDIKQGELIIRERPLFVVPPQISVSPTTLIAQNLQRLSPAGYESFFNLSYVHLPENVDPDVDINEVALAIFQTNAVSAGNDVGIFPRMARLNHGCSSAFNSVYMWREKEGVLAVHALKDIKKGEELLTTYTNMKRPRNQRRQYLQQQYGFYCTCSVCSLPDAESNASDHRLSSMSDLYTKFSSWNSRSIDGLEAIDVVQAIWDLGNQEGYWSERGQLAADAAFVAAAHEDAVATKEWSRLAAEWFGIELGSDSEQVMQMKGFVAQPMGHPAWGTRQVAEVGGPKRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LP90</accession>
    <name>A0A8H5LP90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LP90"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="110" mass="11990" checksum="8149CB00FE26B096" modified="2022-01-19" version="1">MITLSCSSGELEDGLSAVMAYLSLVAKEATLHSLDIKHSDYSHNNDFYLASVSQLKNLGACKLYFRGDVLADEGSVPMDLWALGHLEQLEVLHLTLLEKLISVPSAQLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPK7</accession>
    <name>A0A8H5LPK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPK7"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5364763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="526" mass="59353" checksum="BD6C702781135B62" modified="2022-01-19" version="1">MDQNTSTIAELRAEQVDQISGNISRLSYRLASLDPSADTDSSSSSPLPRRLQWVVDRSKELFNELEPKQLVVVLPTIRQLMERVDERKWLDFGELDNFAKLLSRLVILKERKNKLPVVRFLPCISDFPPSELNGPAPAEWLAMFVHSDIPSVCIEDHNACCNVCLEDFEEPALAAEFQVDGDDDDGTQGSPKPLRQLTCGHVLHEDCLPMFQIDGYDEMFECPVCRAEIWTSPPSSPLSAEIPRDSVLNSISLDQQQTYGNYYYSPPPWLKIDENSLEWAAWYRRVGKLDEALNSTTHGHPVNLIALGIWGDQTYMRYVYSRITDGPEGLVDCLIVGPDRAQSIGAHISEGEHEDASRQLRGYWDFLGLQYAPHFLAVLNKHNCQDECHWVVHRFSLLDGALTTYHFHTDLHACPDCRPVSWWSIICLAWPNAAICSNPGMPTLIHLHQPMELGVDDCLAAAGVRHNILMGLPAEHSVDLECLRDLMHTEVKGLCERHNSSVTYLSTFFGDLHGRSERVEGNKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQG9</accession>
    <name>A0A8H5LQG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_003327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQG9"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="12795" checksum="0B58A8B5E70716EC" modified="2022-01-19" version="1">MGKRKKSSRKPAAAARIKVPLDTSFTCLFCHHDNSVTVRIDKKEGIAQLVCRVCDQRYQSKVTHLTEPIDIYSEWIDAADEAQRMRESSTARRSAASSSRPAAPARSADVDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQN5</accession>
    <name>A0A8H5LQN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQN5"/>
    <dbReference type="OrthoDB" id="2588159at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053161">
        <property type="entry name" value="Ulvan_degrading_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848">
        <property type="entry name" value="DNA-BINDING PROTEIN (PUTATIVE SECRETED PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848:SF2">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17132">
        <property type="entry name" value="Glyco_hydro_106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034534067" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="111789" checksum="7FBC94023E796694" modified="2022-01-19" version="1">MHPSALLTGRLSSLLLITNFAWSQNLPQNLPRGSFQTPKTGVKWRYWIEDADVDPDTLRFDVSEIARLGSSGFELLSYQSYGSIGSATGDIVVDPTDFAFGSDRFVTVSAALVQAAMENNITIDFSLGPDQGAGVPVFPDDVDMEGMNTEMVFGTHFIQPGDSFNGPLPSPIIVPFVDFRGNVASANITKMSLVGVIGAELASGANTSAARVSLDFNTVVDLTDQVQGSVDDGTASVSWTPSNNNTSVLLSYFSRRNGWPEAKPGFHGAQPDEPGSWGSWAVDHFSAKGANVSASFMQNNILSQQGIGDLLRQPGVGQYMWEDSMEFRAQLFWTEGLPQRFMERHGYNISIALPVLHTLRSSPFSNPAINRTFDYGTSFNWGKFTEDYQDTLTSLYIDYMTALSDFARSVGMTFSNQPGYNFRLDVAASAAIPDTPEIESLGVPTIDQARQLSGGVHLGNHTFFSSETGARPGEANALRMIELLEDAKTQYAGGVNVALLHGIPYSGDYPNTTWPGLTTFGYRFAEMHGPRQPAWNYYRGYLDFLARTQYLLQAGVAKVDLAIYRKDYDITSKFPFQGTSLISAGYTYEYISPENLKLPGASTVVDGRLAPAGPAYKALILSRIQNITVDAAQSLVDFSDNELPIIFVGSVPDDVPGFETGDSQKTQVQDLMDQLVNKSTVAVVDTEDDVAGALAQMGVLPAASANSKSPNLYTVVREVQGESDSDRTSHFYLFNSNVSTGGSVPGLINFTLTLNPGFNGTPFVLDPWTGEVSPIVLYAVDDNGSIVIPSISLAPAQTALFTVTTLTSFEGVAASSAHLTDAGEGVIAVASSTGVELRSFQDGDAELTFSNGSTQTVSLSLSDETPRELDGWQLNITAWTPPDDLSQNKSQPILVPMVPINLTQGLVPWDQLDGLANVSGVGTYVTTFEWDHTEDGGVGLQLDFGKVFHTIKAWINDVEIPTADPTNPVVDVSDFVRQGTNAIRVDAASTLLNVLNSVGSAVVTLNQPRNVPPPANQHYGLVAPVRLIPYARAVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR56</accession>
    <name>A0A8H5LR56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR56"/>
    <dbReference type="OrthoDB" id="2654453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44633" checksum="DD5FB26C0639AEB9" modified="2022-01-19" version="1">MAPYSFTTKPDTKTRKSTKGKYTLHALLDGHYGEVACIAAHPLGSHVASGGRDGTHIWNLQEKKLLGSPAGAGDRGVTTALAWMIRPDDTDDGLAFGTDDGYLSIWWRSRKEQDFAEVYCNCLEGGEDGQEIAAMAFDATSGQLAIVHRSEIVHQFVVGPLMRLTVVKLTRIKNHWPQAVAFGQTAARGPEIWSFGREDSEINIIDAGGKVTMTKTTGVVIGGAAISVKDDAYILDDTLQGVALYKLSGSERVKTFAVETNERRSRNVCFHDGRKAIVTGSDHGDVYVFDRRTGEVNDIIHVGCKDWVQLVMTTEMEGVPMIIVGRSGEKIGRTALQVWERKTPASRPEAARQGRLLQGLSGWQVICVLLSVLFVLQNLPPEAREWMESVTSLDFGIESVASLDLDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRA8</accession>
    <name>A0A8H5LRA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRA8"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21559" checksum="882BBE4363092814" modified="2022-01-19" version="1">MTFITHRATRSGAIDPSLIFHYTNKVGRISHDPDMAINLHVTQAEQILNSNSGWKSLTGTTDFAEITQRAGEGSEVHQMAFNLFVDRILNYIGSYHLKLEGKVDAIVFSGGIGERSIELRKAVSEKVRCLGYNALDETKNESLDDDKAARVVGIDVRPEKDSGVESRILVCRTDEQFEMARQCALEDKFWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSN2</accession>
    <name>A0A8H5LSN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSN2"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="327" mass="36424" checksum="230D355207E137B3" modified="2022-01-19" version="1">MSQTQDEQYVNFDTSEAISTGLPAAAYDHFHAIPILPHLLPSPPLPPLPMPLYLSEALQSKTLTFTFDGCTESIPNLHEFLCSWPPSRLGAGGKNNDGTYRTMNTVDVEWIAVNTGQSPWPTCGSGNTSFLGSPSHHQIPNQNRRETISSILHSSIPVATLGSLQNSFDHLVSSHRVDGAITLTVSALDTLALSHGITSGKWFMFVDEDNVDRVWTGVVEIICLKLGAAAKGVFARVGKNRENRQSQPFQRHDRPVTVNQEYLIYIYVPDFSNVSLVFSIRQALRDLGAELGYRGLTKKIAFKMDLYSVLGIYSRNQWRISVNRWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU05</accession>
    <name>A0A8H5LU05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU05"/>
    <dbReference type="OrthoDB" id="3061698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="543" mass="58697" checksum="0093779E68B9F2D5" modified="2022-01-19" version="1">MPLLGKRTRNQRPPVLPLGPPTSSPVRSSSIPPSSPPKTPIRKRAHSAAHGKGNENEHGDGNVSGNGLDLPAALLQNHDASPEIDAIVITSLSILPFCCHEDLCSMSKSQLVSVAERLNERLPRAMRIEVGEGYSRSNAEANVGPSTSPNASTERNDERERGSKRWIRKEIERIVDIKTTDSVSGATGSQAQALGPPFALALPLGRIPPSVSEPPLPLSLPLLASTLPPAAPKANRMRRESEVNANAHVQTLLQTEPRTPGTPRRHLHTPGCEAKTPRTPRTPIGASVGTSAATPVRCDFISSFGTCTFTPSQLGTPKLERLDEVDEGRGGSSDSDETRYSQSGDDDDEDEEDRPTKKRRISSVRAEAPWPTDQRPKPQLQRQRQRHPLAESMTRSNSSTLGLITSTSIATSIFSQDPDVHSCKPDSIFDPNSDSEDDEDEVERLVRSSPTPTSVPAQASKSLSTSTSISNATPPSRIPVFKKPKLSHVHIGQSTRTRFTRSKTVSVFGSNTMSNAMPGPSRRTARTSSFTGPSIARDYDEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU86</accession>
    <name>A0A8H5LU86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU86"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5369772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="381" mass="41655" checksum="8BE80F0BB1AD87AC" modified="2022-01-19" version="1">MDTELKCNRLTCRKALTDKAVVTTCSHIFCVECANELFNAARLCPACESSLTEPSALCTRQTTTKLSEPFYNPGDLQQSDFVLAIPNTSREVCICALEEWITYCVVASTFQQAVLRNLNDKNAQLQKQLDNVVREANSEISLLNNKNAELERDLEVERRKVRDLQEATREREKEYQKLKAQHDKIKRKALLAPNLGVNDAVNSSNEEPRVAMRPLEGNIGNIGAVAGGMAANGIQRTPIVNRTSFGGFPSQRMVPSGTTGGGNNGGGDGWVPVHGNIQQHHARSTGGTHRQPLPRVPQERRAYRSNGNISDQSDSSNEVENLLTSGNYQNFGVPTATTGWSAAPAPNANAGLQRPRPTAQKVFAPSSTVKRSSGKFRPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVP1</accession>
    <name>A0A8H5LVP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVP1"/>
    <dbReference type="OrthoDB" id="3006080at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="531" mass="59426" checksum="95305B88CACC31DE" modified="2022-01-19" version="1">MSQNWTFYNAPPPTVDPNTGAETTAPGIDPSTPASITYAEYIAISNAIAAIADLQTWRTATTTTLDQIQTRLGNQSTTLHDIQTTQNDTITSIRNIELIVRNLTQQSSTTSAQSPTGADQTSTSSSSDPTTTTTSTTSSSQKPPTFTLPDKFKGKASDVEFFIREVKDAVELLGLSLPSDRHKCIWMSTLLGDGSPRQWYFSLMTGEPTVLNSFDDFVERFKDHFGDSNLNYNAEVKLKKLKQTGSAAAYASRFSELVVHVDWSESTKINQFYSGLRTTTKDYISQTHRNDRPKTFTAYKKWAVDIDNRVHEREEERKEELSSKSSSSPSKPAKTSNSHTTPSTTNSSSNSSLPPGEPMQVDATKTGKPRPKLSDEEKKRRKDLGLSSFSVPDNPDVKILNSRRFFRQAKGCQVAYLQFYDSASPHFINSFSPHSTPDSTLPLPEPPPPIGHNPLTDPDEDFSSYVPPHYRSFLDSVFKVSDFDHLPEHRHNDIEIKLEEGKTPPFVRMYRLSEQERQATVKQAWYGPVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWJ6</accession>
    <name>A0A8H5LWJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWJ6"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="24237" checksum="4888E6D312FED930" modified="2022-01-19" version="1">MDSSTQPSLPLSSGDLEAIMDLILGVAVCSVLYGVDATFFLTAIWVFLTKPPQGLPSTSESPHAQPRSCFPFNLNLSGPQILLLILIILMLSISTGSLILNIQYALLQISTTGYNVDFDAALQLSKNILIGHGFLDRLNFLISDGIVVWRAWIMFSHSLFVRGVLSLCMIGSTVGTFVDAGMLAIRIRRDPTDIGTPNDGLVVNVPLLTTNFISTSFIGYRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXW8</accession>
    <name>A0A8H5LXW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_000648</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXW8"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="555"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="863"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="986"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5373627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114427" checksum="E4446806D38E2D6A" modified="2022-01-19" version="1">MSGTSEKSTQPRVVIVGAGLAGISTAIALRSQLRFDNFTIYEKASTVGGTWRDNTYPGCGSDVPGHWYSLSSELNPYWSRYYIRQPEIQAYWEQLFDKYSLKGNTEFDTFFQAAEWDSNAQRYNITIQDVKTGQQRHATAQIVIYAIGGFMDPVYPKDVPGVENFRGLVWHSAHWRHDVSLKGTRVGVIGNGASAAQLIPEISSDSSVQVINFCRTPQWYIPQGNYSYPKWIQWVFAYVPFVLRLYRNSLMMRSDISFLIFRKSNKRLLAATRRVMTRYIVKMAPKDQLDKLIPNYPPGCKRILVDPDYLSSLHRPNVSLKWDTIEGVVEEGIKLKTGEVVPLDEPTNFHLRGSRGTLIKDYFATKGGPTAYLGSAVPGFPNAFLLLGPNVASGHASVIFSEEAQIQLILRLIKPIIEGQIQSIEVKDSVSDKYNDWLQTRLETSVWNDCHSYYHVAGTQRSKIIATFPGPVALFWWFTRRTKWEEWNMVGELRWRERVFGKMGVVAGIVASVAYVVYKQTISSLLFGSSAFGRSSFVMASSSHSSTANVVGVHYRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRILSGCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSIKTVCMAARQMITRVQTIHDKNLIYRDIKPDNFLIGRPGTKGANLIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYEFLRELFAKVLKNNNDVDDGEFDWNQLNNGKGWEATVGHNQMLTQMQNAGLTASPDRRREHRDDRRRVSQGGNIAPPSPAVVRHNSKRKAPAGLVPGGANTPGQVTPHSAAAQVNVPIGGSPQQRSSAHHPYASGGYDYNGDDAYNQQQYDRASPMISSAAAPPALSTVRARGGDVGASRGEYDGQDVEDPPPKNTLVRILTCRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZE7</accession>
    <name>A0A8H5LZE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZE7"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5375006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49024" checksum="CCF30316B3EB3C4B" modified="2022-01-19" version="1">MLFTAFASWPSAPLTHSLVLKTLSSFNCRVFSSLQDVPPDCPLLQWSTYDEIDHEITNTRHQSTLSSSYTFRKALIRKHFLSRCIFSYLKKHPDSVLKDAWPKTYELEISFVDELDELFADELWELAEHLEGSQKWWILKPGMADRGNGIRLFSDRKSLEDIFSEFEEQSDEEEEEQANPTAVVTSQLRHFVIQEYLVSPMLLDPSEKSLDGSPKPEKLKGHKFHIRAYCVASGALTVYLYDRFLALFSAVPYSQPAKCTVGDTEQVDLTPHLTNTCLQVADHGEEGVRLFEELVGCRIFSESGEETQAALTPEDISEMTNQIVSILSETFKAALENPINFQALPNAFELFGIDFLVTSSATSTWQVNLLEINAEPAIEMTGPRLQWILEDLFSSIAEVAVAPFFSESSEVDWAIRETRKHLIKCMETKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AUZ7</accession>
    <name>A0A8H5AUZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000554">
        <property type="protein sequence ID" value="KAF5311391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AUZ7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5311391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54104" checksum="C8E57ACBD5A2680E" modified="2022-01-19" version="1">MLAEDYLELFMGEFHRWKDVSLDMSVFNITPDTTNNQHESDSSGIFAPLSNTPLPMLEVLSIKGLTTNTHPKLPWIGECPKLHTLRLFRYDPSILPTSLQNTWSQLTHIELAFVKIDTILQTLSMCPNLICAHLSLDCRISHIQAILRHRVSRHPTLINADSNPNQIILTHCPTLRELHIRLWMGSRIGTLLTYEPLMDLFQNLQCPTLRTLSLTSGAESVTESSYLAQAHAQSQRSWSRKHVNGFLSRSGLASVSVDGTSTGAPANVTATLRRLVIKYLPLCTSDVLDFLRNIPGMTDLTIHDVRDVRDGEAVGMWRHADYYNQEQLDGLLTSNSSPSIGYGNPSAGPKNSILTEEFFEQMYVGVGLVRQAHAAPSPLPSPSHSADLLPNLSRLEIKLWNSNKKEDVDFTQELEKMVASRWQARVSSANANKRTGLECVVIRLMGTPYPFDHLRRFRNEGMLVKVVWDTEMGEWNGRGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRY8</accession>
    <name>A0A8H5BRY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000363">
        <property type="protein sequence ID" value="KAF5328459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRY8"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5328459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="442" mass="48948" checksum="222A67EE9C95A06C" modified="2022-01-19" version="1">MSDAGENTSANVWGNVPPPSSSPPFSPTSSVALSMPKNTNPNYVMLLSDINKAFDSLSVLTGSENWKMWYFRANNALQVIRHQHFKSSRLHPGNTVKLACFNAITGKIDDKIMIHYIEESDVIELIEKLKQRFDPSSTVQEPNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRGIDVSDQVFYSALVGIIPLHYHFVRSSYEATVDAAATTWDATTAPEGEKPVYTAVDLIARLKKEFTNYRLSNARMYPSSSGKKSDKKSGSTSQGSAQQSDKSKGERANAAALYQKPSDGKKDRKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKAKENASVAVSMPASSSSQVVTTSTLQLDWVQSISSGNVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRZ4</accession>
    <name>A0A8H5BRZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000378">
        <property type="protein sequence ID" value="KAF5327976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRZ4"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25250" checksum="7B68B4051FDE8F0C" modified="2022-01-19" version="1">MSSGSSFMSTIPELTGPNYTLWASKSKSWLQSQGIAYVLNTLKPGEIQIVGSTSPVPAPPAAPCAPAAPAGTTGGTTAAAAAAATDDEGSDAGSPSPHFIAAASGSVADWEKDNDKAMGVIKLRVTQAIGAKIKNITTARVMWDTLKNLYGTPGAAEVFQNFKRAMNVEIPRNAHPSAAIDLIKMYLTRITNAGANTEIPMYLQYMIIINKLPPDIYAYIIARITQDDIDDFENETLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTC5</accession>
    <name>A0A8H5BTC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000378">
        <property type="protein sequence ID" value="KAF5327982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTC5"/>
    <dbReference type="OrthoDB" id="3247165at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5327982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="508" mass="57559" checksum="651B3FF70D58D37C" modified="2022-01-19" version="1">MLSCKDMYKISAKLATALNLAHLPFGGMNMIFAGDFSQLPPAIGGEGVALYSHSIGSSPKSKSDQESSIGQHLWHQITTVVMLRKNMRQTQTSDRDTMYRTALENMRYRSCTPQDTTFLRSLIASPHNSTKSLREENFRNTPIFLTYNKHKDVVNRLGTERFAAETGQKLTSFYSEDEHIVDDIPEHEKQSRKRRKSRKFKVNNSIQNQLWNQPHSYSDKQTPGRLDLCLGMPVMIRFNSATELCITKGQEGHVHGWKSKKGKHGKPVLDVLFIKLHNPPKPPSPIQFDGLPENVVPITRNTVRIECKLADDSEITISRQQVEVLPNFAMTDFASQGKTRDWNVVDINNSKDFRAIYTALSRSACANQTLILQGFNTSLLTGGLRNKGGYRQELRELEILDEITRLKYSSQLPVSVVGDRRSSLIKSFRNWKGPNFVPSNVHESIQWNEADPLPDTLEPAETWHIIEDDKSPQKQKGRQIKGNFKPAQGAAEQPLQSTLKRKDSSQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVD2</accession>
    <name>A0A8H5BVD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000331">
        <property type="protein sequence ID" value="KAF5330274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVD2"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034963291" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5330274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="26698" checksum="1AE1CE0BAAB97C6D" modified="2022-01-19" version="1">MMFMLTTLCLFFLALVRAIPLESRDVINPQIMSPDASTVWVVGQTETVSWNTTNLPPDSQITNKLVTVILGFLESGDDSEHLMLDNPLAKDIPIRAGQVNITVPSVTPRNSYIVVVMGDSGNVSPQFTINAGQSLPASSGSSSSSASSNSASSSASGSSSRSSSSSSLITAPIPISGTVITGNPSSVPSVTSSGSVSAASPTATTPTTSGSSSVSRPSLGSSSSSASAESASQTDTNSAAWGMSFNYPCSFILAAVIIFLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYP3</accession>
    <name>A0A8H5BYP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYP3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5331456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="184" mass="20800" checksum="71387447BBF3F6BF" modified="2022-01-19" version="1">MQPFHHHYTLSRQGYPLKRSPGVLSAGGLEEGFGHNFGIRDESSRREGTVAGTWSDEDDAGVSVFFSRPLPHNTALTFLLQVQIRPKCPAFRWYPDPRLATLFWGLSSIIRPRNRQACSCFAKRTLAATTNANVLPNGRSSVEYFKLRDAATARPLWLLVAYTATLTRRRIILLEPELTMKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYU7</accession>
    <name>A0A8H5BYU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000317">
        <property type="protein sequence ID" value="KAF5331791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYU7"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="3">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5331791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="695" mass="75757" checksum="6B429CB256A82962" modified="2022-01-19" version="1">MTRGLSLLSSTTPTNNTPAQLHISHVQLRDLIICPRERGVVNYVTRRSIVEHNVNTPGSVPRTLVDLDFSPNTLSSLQLDEKGHTLLAAGGQEAELHLSLHNNNSSTSRRTPSWTFYDRLHASINNSVKLTSLNVTRSHESSVEPRIAISNNDCTVKFFDIPISVRGSTISKIKDVGTVSLNAPVNHSSISPDGQTLLSVGDSSKVFLHRISGGSRLTFSPISTPVVPSPENSPHFYSSPTFVGSFSSAFSPDGTKYAVASQEGVVAVWDVRSTKPLKVFQTDKTRYPSANNNWGVTGTGSATGWLSDDPYEWTRGHSRAPGWCVRNVKFGGTGCGKETMIFTEHTSLLHVVDARTFETEEIIRVPPISSSSSTLSSSQSVTSSRSPSSSTTRRPLRNQVLNSRARYYQRPYQRPTSTGSRHVSVSATSHLSSRRDQSQPPVPPYVILALEDTFRISARGNVTTSSSTAPSSYRDLFSSSSSLRSNPPQEPSHDGTDLAEDVFGAFSMPRSGDDDEDSDLVVIPTLGDPEVEDDVRTLLGRHGLQGRSLDMRDGGMINEEDDRMDVDEMDTERSAPEPEMEWDCISSHAPSRTSSPPPPAASSGNRWRMWPAVEPIVPDDDESESEDEDGIGSGFGTGKGQDSHSTLSTDDQDIAGTCFDPSGAYIYVGTTDSVVEWNVRGAEKTWWLDDGNEWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0T2</accession>
    <name>A0A8H5C0T2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_017892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000301">
        <property type="protein sequence ID" value="KAF5332898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0T2"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="9">
        <location>
            <begin position="132"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="513"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="752"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="838"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="881"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="924"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="967"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5332898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1093" mass="122353" checksum="0BB2CB2DAE4452D3" modified="2022-01-19" version="1">MGTSEDGNALQQGNNTIRHHIGNQSRNNSASRRQIQENSNTGEQTTVVNQSMFPNASNFTMTGVTISNVGRDFIQTTNNNFGANEKAEILKELKQKLNPISKPARKTDTCLEGTRVKILNDLCDWVIDANTTIAWIYGIAGTGKSAIAVSLARKIRKIDTKKEVKLALTFHCVKGQETSHICNLVPTLSYHLAQVFPEYGKGLLESLNRDPSLDGTSLSLSEQLELFLDLPVLEKLIIKSSEKVVIIIIDGLDEWGTGLNRRELLRHLKTLNQFAWLKIIVTSRPNPEITEELMGEFFIKKIDLSDHIGTADDLRKLITSKLSWVSNEKMDNMLAKANGLFIWVTTALTFIEMGVDKAGRLEIILNLKKGTYDELQPYEPLYHLYKTVLTESFSQQDNLKYLTVVVGAILAVIEPVSQDTLKNLLCAKGVDVPTRVTEEVINQLRALVYDRDGKLYYHLSFGEFLTSSENKLNIHPKFTHLQLANGRHVVSGSADYTIRIWDIQTGQQVGESLEGHRDRVNSVAFSPDGRHVVSGSDDNTVRIWDIQTGQQFGEPLEGHTERVRIWDIQTGQQVGEPLEGHINEVTSVAFSPDGRHVVSGSNDNTVRIWDMQTCKQVGKPLRGHTSWARSVAFSPDGRHVVSVFNDVTIKIWDMQTCQQVGEPLKGHTEWVWSVAFSPDGRHVVSGSEDYTIRIWDIQTFQHFEEPQQLSNHTDAINSVAFSPDGRHVVSGSDDCTIRIWDMQTCKQVGKPLKGHTDWVWSVAFSPDGRHVVSGSADRTIRIWNMQIFQQVGKPLNGHTSSVLSVAFSPDGRHVVSGSGDRTIRIWDMQTCKQVGEPLEGHPDWVKSVAFSPDGRHVVSGSYDRTIRIWDMHTCQQVGKPLKGHTDEINSVAFSPDGRHVVSGSDDRTIRIWDMQTCQQVGEPLEGHTAWVQSVAFSPDGRHVVSGSGDRTIRIWDMQTGQQVGDPLEGHTYWVRSVAFSSDGRHVVSGSDDKTVRIWNIDPSNPNLIPASISQYNQEYQSCSINTQGWLCTAEPEPKLILWIPPHLRGFNDLRQAGTIPADAENFAVKVDWSKFVCGEDWTSVWNDNPEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2F6</accession>
    <name>A0A8H5C2F6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000275">
        <property type="protein sequence ID" value="KAF5333992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2F6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="157"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="358"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="91244" checksum="A54E6CC7ED34EF3A" modified="2022-01-19" version="1">MGETRFEGELDVGADVVPFPFRAGPEGNGGDLQNRVGWVRGEEEEERTYVVAVVEWKRHCSCYFCRTQAGIGGGDCLVSRVLERHNGRYWSPQRSSSRRWRSKWSESSRIRFRAQRFLTSFWPRNIGSCRSRLLSLMRLLNTKTLKLAEFYADIPLYAILSHTWEKEEVTFQDIQNLETARLKAGFAKVSNACARARNYDFEWIWIDSCCINKESSAELSEAINSMYQYYEDAAVCYVYLCDVSIEFHPRNLKSTFKDSRWFKRGWTLQELLAPDHVVFLDKDWVRIGTRWTLRDVVSAITSIPVEVFEGWDINTYSVAQRMSWAASRETTRAEDQAYSLMGIFGVSMPPIYGEGGAKAFMRLQQEIIKISDDQSIFAWVAASSERNEHRGLLAKSPYEFRMSGEVKASESDCIGDRSSYSFGNNGLHIHLPLESIGGDDLFLASLLCQSERDGSFLSFALRKTSRHQYARCHPDQLVFRPTLQPALNNIQELTVREIPVTRRSRSYVSVDLFESLMYHVDLLPSAQHFICTNSQSWHVIHSPNLSRVSVRLQRPIFDCKLTYKTQVTEEAFTIHLWRGGFPCYVLQLGDQPLKWPPLIDESSPDDGTVVCSNSGAISVHSEVTSDRSARRFEIGVIDRDSLEINFWTQTLRPPRSGFIVPSMYYGPSEMIPLVGVYPFDFYQKTFQDMAYIPMSPTDDPFRILTYGRPGTPSFHVAIGLLGPSCETYWTEVMGDGESVEQLYQSYLNRSRADKLGQLGQTSTWSDSLYVGSLIASVQERSSLRLGTHLLRLEWIWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2Q7</accession>
    <name>A0A8H5C2Q7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000276">
        <property type="protein sequence ID" value="KAF5333979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2Q7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="20987" checksum="6734A5A230D1A646" modified="2022-01-19" version="1">MSRRNLSNIPDPGVEEGDEITISGLTIGRLEPAEGFSSFAGYWSYVFRDKRSSAFETHQYNYGRVGDRKRFVKRRSPSQLDFVAEISSREDQASNENEDEDAMIVDELDGDRANNSATFNVSLDSGESDDRKNGQNTGASIHTPKRSSSPGQQQNIPKVDLFRDAQGFQFHNSVMNNYAIGRHFNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C346</accession>
    <name>A0A8H5C346_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3251015at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1717"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2165"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1731"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2179"/>
            <end position="2197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2303" mass="261201" checksum="A0E828943D21CE72" modified="2022-01-19" version="1">MLLVRWLCQVGIPAFPASDDSLSIFQHLVNYILHNSHAPSCTKPSTLSIFHKRGSRTLLRNCRGVTFSNYILNHIGAWENFHLVPYCAKHNIIPPTQIASQPGVQGRDLLSFLAHLQTWAVRNKQSLYVLQRDQQKGFDMLEPEGFYDALRAYGLPQSLIDLDISFQSNVPYSILSAYGLTDPFIVNGVTKQGGPLSPLKSCLMTSLGHYWLNDLLRNDPGALVISTANCRNRCFHTPIDNVTFLVHMVEAMDDSLLLATRLSTTRHACLAMERLQSCYGAKTCWPKSCMYFLNVIGPIPQTITMPTVSPENPFDECLVPLATVPVSSDCIHFLRTDVDRPKAQYFFLRDLIIDFQLPLLSKQLPLTAIRCILSQCLISKIRPRLSYQPISHADAVHLDVLIASKVHHYFGYPFHPSSTLLSLPVSHFGFDFPSIAELNLDSAVRGLLRDLNHHVPVFRQMARITLADWSCSLNCCLHPFVYDSLHRSFLPFTFSSHRKLPFVWVLAHDHLQKLDISLHSMDQSHVFLGDVSLQHCVNVLRHSRSFSSVHALPNFRQISELCNFNLDKLSDFSSWTSFPSPHLQLSLPSSRRFPSNFLFMTWYPLLLVLHNLSLLSLVHGDSSLALPRDIHQTTAESSFLQMVTVPSFLSRRHCDFPSSTVAADASLIPPSPNVLQHRSITFAALHDSHSYVASVQTSRLFSNILHGELYALILATLLYKKHPTSPNLTLLSDHLNAVRFLSNALSHSPSATVWAALPASSLYRWLYSLLISLPNSPTISHVRAHTSQLDIPSQANALVDRHASLAQQLSTPSPYAPLPTFAMADYVLYHSSFGYIESGIPEVLKSLYRQVVVDPLSFSPAARMMRSLYDPHPPPSHPYLRASSAYSASIQLYLRSGQLPTRQITALRLHEKSSLCRFGCCTVESPHHLFVQCTHFNRIRAHYTARALESLQTHAQSMGIPRHWHENLHRVANVLFYDHSLWPLSSSRYYFGLLPEIQPHIPLVPSWSTLARERFITRLSNSWHYLAIQLAARIWGYVQRLRAYKYLTWFIHVYVKWFNEQAARQLGGPETLVIRAIYVDGTDADVDEGRVTSARGKQGLIFRLDPSHKHLKRGQENCAPQSLWPSDTSLGLDGSEEAYSNAPFKLRNVYVDGKHIILDFTCVVLMVDPLLHTSVQIYPLADWNADVYNVNKKLCGFKIVLAFEVWHFILCIASADSNVRVKWVDPKRFILSIWKEDNWSSLQSVIAGRRCWFDEANPPAYTPIFFDPMDQPVAFMEECAVWWMYEMRKVFNRKTYASRELWQWLKDEGRSSPFKGVGTYTDEEVIFYSGKLPWHRSTYVYSSPSSTLQTGIHPMTPMRDVLNCPSRFSRLVLAYIQFILPIHRCDFLYQSQKWHLLSRRNHRSAPGVHLLHVGSTRDAYPSDDAYECDEGADVLLGDCDDDALSDMSDLTDLSDDLYSGQAEPGGLPSGPQISIHRKQYNLDLSRFATGIVMQSASEKQIARYGSRHVRVHGQARTRTTARHAKYVKEYNSRINNDASSRETFDDPFEPCLIKDAMTIHEDLVNVVLRSDAVACGSDSNNALLMAFSLVHKYRRSWLNRKCYLPEFTPLFDDKGTDHLVTARPEHLGLDACHVRPYQEFVPDPASSTLSFAKPSTASAVDDFISPQLVDGKLGFEPAYLTPRLWLKLKKTHLNRLTEPSNGQSVITQFFGVTGNTVSDIPESEDEERGDSSLSTSQSQKAMKDKVADDFWSVVDFKVGGRNDLRSASETEKRKKLMSYVKKYTAGWTVGPYDFCAVVVVFDVNNRRRRLLAISRAGSSLHRLDYHTLNRRRDYKKENEQTKKAEKSRIRRLEKRKELAERLKYEKATQLAIRTGKPIPKFKKRPGPRPRIRKLHVFKASIGLPPQGRWGGQNKLSRSDRQALREATMWRAVEQREGVRHEEERGGTQSEYRDPPLAAFLSCASSRTHDQRSPVLLHESPPRMVSGPSSDFTRQFQVQGPSVYCVTSSDPSVSSCNLPGLTPAYLPPLPGSSYPNQEGQHHVPCSSYGHRNREVETGDDVASDAVDGPPARKRKAIRVRAGVENSRVNQFRRQKLTSKPLGTVFNNDRRSGDNVSGWHGSTGFIGYVHNTDTDRMDCTPMEFASVVDRHMDLNCLLSRSVYDLPSYSTDMTTPRRKKRSDQTDQDKRSPQKKTDSRKAKVNRTVVTSPKSRQTVLDAFIGKDAGSPETTEPRYRQLTIDRFTRRKGITTKTEEYIDPDALLAEVIDVDEAFKTREVETFGYLPGPVLDRPIREVDVQDSKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C379</accession>
    <name>A0A8H5C379_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000266">
        <property type="protein sequence ID" value="KAF5334158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C379"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034558658" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23283" checksum="EC46FC48CAB0A447" modified="2022-01-19" version="1">MQLTGLITIAAAFTSALIAPVSAVPAADSTNAALSATLGSTLTASNHYGAPIPPWEKGAYPGWYYGDHPEYLDIFKFFIPHLKDSLICKLLDLLPFCLHCPKPKPPPHHPPPPPPPPSDGWSQTFSNLTAATQADGFLTFGLVDTIDDCKTMCLGVDRCVFINTYHDVNGKDGSPLLTCSLYDRCQDADTATNAGGQSQPDGSIDFITNSDGFCHDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3F8</accession>
    <name>A0A8H5C3F8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000276">
        <property type="protein sequence ID" value="KAF5333976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3F8"/>
    <dbReference type="OrthoDB" id="3046222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034703914" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1047" mass="119092" checksum="D936F89956A6FF4C" modified="2022-01-19" version="1">MMGLGGICKAQLHPLLTLSDLLCARLCPSLQMGLLKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATWNCKGNNGKKNQKGSIHATTIAGGRRATRSVLVGDDITTRLYRYIHAGCHNHPRIPYTKHLTAQEAKDTRQHLGNNMHKKHLESYEGGETLDGPTPPAPQLAQKFANIETYRYETKKMTKGATAEVGWSFINQFHSWIQQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAELVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTELENAAQSLIKGCRYHFEKSVTRVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQRKMDSKLASKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDRSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMEHEYHSALYWLYYLIRPRGGPVNPEAVKFFLPVVQRLSSCSEGHYQVESPWTTSSTWQEPAARYLQLFGGKIENWFQSIFNLSSMEVPQEIQGCWRCHTKEGTNDPDIYCNGQCQKMEFISWIPSVLIIRPGMDEKGNQPDWDFPRELYPGSKASGSRDGVVYKLVARSPFTSFMYTFTPLYYVTNAPPQGVPADLPIPVYDYIHAVTTSSSQSLRQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4I3</accession>
    <name>A0A8H5C4I3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4I3"/>
    <dbReference type="OrthoDB" id="3252135at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5334848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="552" mass="61017" checksum="06E6FCC7A0ED5BF9" modified="2022-01-19" version="1">MYKARVLMYFETDLHTHDPLILDLFVMKCFADAESSAQWGTMKTSPPWSSHKRATVAVFQLPAKQVSQAIAGNGHKSQMTHAKCPLALFKGISLSIDLHFESFLSSQKSFKSHLGGYNLPASPLGRPRRTGTYQKKSGSVTLILTEQPENASSPSYGNQGQVNGVIVLEKRDVVSEVYVKLEGEMNLVIPDQGAHTMVLFEEEQLLWKTSNQSNSTSTLEICPSQIPFSCRFPETFMSPMAQDQLLPLPPSLDVFYPGSLLTHIKYRLKIKVVQVRRRQGSAQSVLGFLGRLGLENFKILNVPIDYLPHTRPPYSIHHLICDPLSVPGFLSDLKRSPDEWVQSISSIKSSREDIAPCVDCHLFIPSIKIFSLADTIPFHIILTGPIRSLQEFVPSSYLPSPSPSARRNSSRSATAQKCSESVIYIYILRQICAKINNGESSAEGTGVRAVRNIIIGHGVVREVPPSIDDDLGRGDEGILKWEGELSIITGSLTSNLGTFDAGGICLRDFIVLRVKPLKSRMQTSRSYLQYHEVAVGIRLVTDEATSAGADTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4N4</accession>
    <name>A0A8H5C4N4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000280">
        <property type="protein sequence ID" value="KAF5333907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4N4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="150" mass="16064" checksum="303A42C04EE6155F" modified="2022-01-19" version="1">MIVSQASIAPRSTVVKNRPGFVRILMSFRIDIDARDFVFLIFTAIDRSKDSCKLNAVLSKVNDLSTAQGLYLFGPPLLGTDTIISVNCASTISPTRNLAGEIEGKLPYSTLLSSVCTYSLPVTLARYPHGSTTSPMGSAASNGASFRDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C666</accession>
    <name>A0A8H5C666_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000236">
        <property type="protein sequence ID" value="KAF5335854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C666"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="291" mass="32657" checksum="39EF18A7F7023F8C" modified="2022-01-19" version="1">MLYLLEVALAASDVRRNTNLASQIPLPSFIHTIPSISSPRICLKADTEETHSRSLTLSLALRRGETLPILIRSHNILRHASQYSKILATRNNIADADVRLREQQVEFLQYTLTPIDFAIKGLSPFVAIYAKPWSIQAHPFVTTNHVRTLQWISQPAFRSHPQRLAVISQLSWLCYGLTPMSRVSDSKGRDCRGRLDVFSNENSELVKIWKEPVLLVTTWRNTEKMPFSGNLYAFPNPSAGVATPDVKLPSAVTVPRIVTLEGVGRSMTTIRSATDRAYEAGVFEAHFHQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C795</accession>
    <name>A0A8H5C795_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_014355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C795"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5336243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="522" mass="57456" checksum="576D4C56EE2549A4" modified="2022-01-19" version="1">MSITHALLESSSGYAIFEVKLTEDIGAHTQAAQDSIKDLSKFGKMVTLMSFSPFKSAAHALENANDISEGLVNEHLQSLIELNLSKPSKKSNICLAVSDSTLGGNIKDATGVQCEASEKAQNIIRGIRLHAGKLLKGLQDDDLTKAQLGLGHSYSRAKLKFNVNRVDNMIIQAIALLDQLDKDVNLFSMRIREWYGYHFPELVKLVPDNYQYARCAQFIGDKDALDEEKLPELEAILDDNATTAQNILDAARGSMGSSLSEIDMLNINSFASRVVSLAEYRKSLVSYLTEKMNQVAPSLTALLGERIGARLISHAGSLTNLSKYPASTVQILGAEKALFRALKTKGNTPKYGLLYHSSFIGRAGPKYKGQTPTPKFGEALRAQVEERLNFFETGAPPSKNAEAIRKVLEELGMDDDGDDEDEDVDMADGDAEPAFTTLEPSPKKEKKDKKKKRKSDAMDVDGEEEEEPSPKKVKLSKEEKKALKKEKKAKAKAEAAEAADGDEGKKKKKEKKEKKEKKKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7T2</accession>
    <name>A0A8H5C7T2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_015087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000224">
        <property type="protein sequence ID" value="KAF5336724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7T2"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5336724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="27582" checksum="34CA3D08DB690CDC" modified="2022-01-19" version="1">MANRTTEEWTALIADKIAQVKSDNSLPDSSFASITTPNELFASTIDHTLLKPDATPAQIDELCDQAIKYKFKSCCVNGVNVKQVSDRLKGSDSIPCAVIGFPLGAGTTDAKVFEAKDAISNGAKEIDMVLSIGTLGSKSYSSVFSDIHSVVQASHPVPVKVILETVFLTDEEKIAASFLSAEAGAAFVKTCTGFLGGGATKEDVQLMWRTVKYKGGSVKVKASAGIRSFEKCLEVLKAGAERIGTSSGAAIMQNAEVAAGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9B9</accession>
    <name>A0A8H5C9B9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9B9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27618" checksum="A050AE0C5DE2100F" modified="2022-01-19" version="1">MPFPPHAFSPFLNYYDPSDSFVDIWRGTGLTGDAYFASRNDSIPLIVAAQSGNLPLVQQLISQGPPVDQKGLEGETALHMASALGHLSIVRALISAGALVDALDVEGSTPLIHAIRFCPPDVAGEIATTLLSAGANPVAMVTVDISRHPPLWFAIRAHKLALVRLLEPLTPQELDVYPPGSVTSRNYVIDAAIMDADSSGDTSILEFLIRERSLPLRATDPTKASQDQTLSVLLDHLLRNKDSGLGGSRYHGRGYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBW3</accession>
    <name>A0A8H5CBW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBW3"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="100"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="21947" checksum="72735BDC5FF5D03C" modified="2022-01-19" version="1">MASSSFSRLHHAARYSALPFLYPCNPTSSTPVRRAMMSALRSSTDMNQTPSITESPKPAAVPSTSTISSDASAPQTVARPPSIPKVEKPRPKIRATKAALNITPEAVLRLKALQRGPTPQLIRIGVRNKGCAGLSYHLEYVDQPGKFDEVVEQDGVKVIIDSKALFSIIGSEMDWKEDALSSKFAFKNPNIKDACGCGESFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD37</accession>
    <name>A0A8H5CD37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD37"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="65" mass="7476" checksum="D0C97828AF720BE4" modified="2022-01-19" version="1">MTAGQSMVYEESEYESPTNQDVISREVKEIGDDTFPEHLAKFIRIEDVDVHGLVLQIRKSSWMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGS8</accession>
    <name>A0A8H5CGS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGS8"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034455200" description="Aromatic compound dioxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26649" checksum="A9A62EA40C06735F" modified="2022-01-19" version="1">MRFATSVICAAVLAGIASAAPLERRDCSTEIAAYNLARRSARGVDVSKRSIYPNMPNQVCVLAPETVRQDWVQMDSSLVRSDITEGQAGVYMLLDVGVLDITTCQPIEGAMVEVWQPNNVGEYGETFLRGAFQTGSNGIVEFTTIFPGHPADGANHINLAVHTGDSMSSGVSHNGQVFFTDPWTTIIGASEGYSANTNPRMMNANDPNYAAANSQGYNAIVDMESIGDDWPSGVVGYITVGINPNHLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CH23</accession>
    <name>A0A8H5CH23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000166">
        <property type="protein sequence ID" value="KAF5341343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CH23"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="128"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5341343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="523" mass="58613" checksum="510A95E1C9AC8984" modified="2022-01-19" version="1">MSSQTSLKILPASYYDHFLSINTKNAKEREPSPVRGDCPLGETLGGTISAAGKFHPETLPINYLNLTAQNPKFTAKDPLPNDISLKINIDALVTGLHNREIGDISDLARWLGKLQHIMHGRSAGEGWRISMGSGSRELIYRTIQAMVKHRDPIFVESFVYADIIPMFETICNPIGVETDAEGICAESLRKTLESWPPGKPKPRFLYTVPYGCNPTGITATTERRKEVLKLAREHDFIILEDDPYYYLYYGPADRPPSYFALEATERTENGQCEVGRVVRFDSLTMVLSAGMSIGWASGPEELLARIERHPVILSRISLLLKLYAGYSLAIFGRIRRSAILHCHSTLTYSAMITADRLDQGFMVEGSGPDSNSDPSLLLIVHPSLFLTTSSRLQSSSLSHVIINALLTEWGYDGFNGKTRSVSSFYRQKRDIFEAAMKSHLEGLTEWQLPEAGVFFWFKLLVPDSANVDVEALRDVVRMLPGAVFWQNGNSGYVRVSFSQPTEDDVHKELNRLGRFLREEIWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHF2</accession>
    <name>A0A8H5CHF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHF2"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19765" checksum="84B7FBE3D9804302" modified="2022-01-19" version="1">MSSRPSIQISSSSKSASSLVTPSPATLADPPMCYVDGAMMDYFLIKVINTLHRKPQRLDHQSQFLFRENAAVDEEEEATRTRLEAIGLHVGMNFAERLCRDRSLFTETLDVIKFVCKDLWTACWDRQVDNLRTNHRGIYVLQDNAFKTITRLSSSEGQADATCKAKLSTSQCLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM41</accession>
    <name>A0A8H5CM41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000147">
        <property type="protein sequence ID" value="KAF5343162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM41"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034201870" evidence="2">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="272" mass="29615" checksum="9C34AA2022DDC022" modified="2022-01-19" version="1">MAIASKILLPCLLGVFVRASMNVGQSDRAIQRQHPVCIVGAGPTGLAAAHALEVKNYSVVVFDKQPEVGGKCQAYYDGDQKSLFHAMGALLISNASYIDTVPIVEAAGVPFLPALSVTSGWIYPPVLANTSVVNVTRTPNPSPAQTNLLESEFSRYTDLRNKIFELYGTMRYTNGIPGDLTIPIGQWLSQNRFQVLPIVINAGLLLISLSTVVQFIIITMCSYQAALILLSRTPAFTVKGTEYNMTQAFVNFGLDYIRMFAPDLLHEIEIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP33</accession>
    <name>A0A8H5CP33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP33"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="26009" checksum="75C58B50A8744D44" modified="2022-01-19" version="1">MARSKEIVPGIGRLSRSQVFAKRGLFKGPKKSDKPAVEPTPETVEKTVGGAKNGGKRLVPTSKAPRFYPAEDVRQPKKSRKSPKPTQLRSTITPGTVLILVAGRFRGKRVVFLKQLESGLLLVTGPFKVNGVPLRRVNQAYVIATSTKVDLEGVKVNDKLNDAYFAKPATKSSKSAEEEFFEDGKPKAKEALPESKVADQKEIDSAIIAAIKKTDNLGKYLQSTFGLSKGQYPHQMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPB6</accession>
    <name>A0A8H5CPB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPB6"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="250" mass="28003" checksum="2850E35B1F7A4387" modified="2022-01-19" version="1">MYTVKWSVLQYVIIRPLASIAGIICEHYNVLCESAGFDARYANVYLEAVDFVSISVALYGLFVFYGLTSAELADKRPLAKFWSIKLIVMFTFYQSFVFSALEGRVIHATDYWSATNISNGLNALAICIEMILFSIMMWWAYTPKEYRIPGAPPTKIWKPLWDSINYSDFAREIISSCRFFVDYFRGVPTAHGHGHMTSTSRPTLATAFRVDSAYTKVGPGSASSDHRWRSTAIINNHNGHNGGAGSTDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPL9</accession>
    <name>A0A8H5CPL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPL9"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="248" mass="27436" checksum="23621D0C9976541D" modified="2022-01-19" version="1">MIALLPELITDDGWVTLALTGAQKTASRLANYFPERFLSYAFLAVGYITPTFFATPFEEKLNLSKAVLGYENFGYWDFFSSEGADQTILDHLDSFWDISFPNDTTVTITDWSPLGALEAFITNDTRIPPVDYVTPEERAIQMEAIREGGLAAPLNWYKIARGTLEGQDDQGIPQENALIHSPVFFGAALRDYITVSAPIFLAGALVSSNSTVTIREYNSGHWVQLALPDEVNDDLLQWIEGLGLGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ65</accession>
    <name>A0A8H5CQ65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ65"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39552" checksum="DCC05523DDEB55EE" modified="2022-01-19" version="1">MTRLFGVFRRISRTDYYEQIPKSAQLGVERKRRLLIVAARIFAVLTILLILGIFVSYKRPDNLFSSSSSPGRSAVFTTLYTNAYALGAATLGHSILRANVNASLVLLYLDDRVSSQALCITEAAGWENHAVSLISPPHGGEGIFYRFVDQYTKLRVWSVGEVLGFDSAVYLDADTLVRRNFDELFGMPWEFGATTDVYLDDRKFAITFNAGVLAFRPSMRTFDDMVGKLEKTDYPLGEAEQGFLNVYYRKDMVRLPYTYNANLATKYADEGMWNELKETMKVVHYTLVKPFWNTDIANDNLTTPEQVRGINGAEGANQWWREEMGWWREVFEDLMNEKGAAIQACYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSL5</accession>
    <name>A0A8H5CSL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSL5"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="85802" checksum="63F49B80646CA2A3" modified="2022-01-19" version="1">MAVVGVDFGTLHSKIGVARHRGIDIITNEVSNRATPSLVAFGPKQRAIGESAKTQEISNFKNTIGSLKRLAGRSLNDPDIQKVEKKFINASLVDIQGSVGVEVNFLGERQKFSAVQLNAMYLGKLRDIAASELKTGVTDLVIAVPGWFTDVQRRAILDAASVAGLNVLRLISDTTAAALGYGITKSDLPEPESPRHVCFVDVGHSSMSVAIVAFSKGQLVVKSAAYDRHLGGRDIDFALVRHFSEEFKGKYKIDVLSNPKATFRLAAGCEKLKKVLSANAEGPINVESIMNDIDASSKLSRDELEGLIADELSRITAPIQQAIADSGLTIDEIDAVELIGGSTRIPAIRNRIQTCFPNKTLSTTLNQDEAVARGATFTCAMLSPVFRVRDFHMNDISHYPIKVQWQPTPTDPEEDTELLVFNPGNPIPSTKVLSFSRKEPFEIEAVYAEPSKLPGSINPWISKFTAKEVLLDASGEPAIVKVKTRLNAHGVMSFESAYIETWEEREEPAPMDVEGQEPQPPKKKRFARKTEIRFVTGNSSLDKSVVESLKEQENAMTANDKLVIDTEDRKNALEEYVYDTRGKLDDRYAAFVQAEEKSKLLAALQEAEDWLYTEEGEDATKSAYVSRLDALKLLGDPIAFRYREHEDRQRSIAQLRETLNLYMTQATSGDEKFSHIEEKDKQSVVEKAATIQKWLDDQIARQTERAKNVDPVLTTGEIGKKRDELIYFATPIFSKPKPKIPQATPTGSGTQTPQQQPEPPKKEAKEDKGPTEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSZ2</accession>
    <name>A0A8H5CSZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSZ2"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="919"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134199" checksum="7909FBE1A32F7637" modified="2022-01-19" version="1">MSHLPPLLPNHQHPSPSDNDNDPDEISPSVALALKLSTLPSDMFDQVLASLAALPYDIWDDDAMKNADINVLQRDMDARRARMTPRDKLETAMLFVEEFDGTRNLRNLNQAIAMMRDAINGFNAEQDTQGRFLGLRQIIPCLARRFKLTGELKDINEVIEALRVAVNIAPDNDVTAEIFYTLGDLLRDRFDSFGEQDDMTESLKAFLKGLSLLPEDDDKHIPLFVKRIAKSLKTCLASPQLIPVFMVTKSELVDGSEAQSKSKRAQILSTLGDDLLEQLLEVGGVQNLDECVDLLRAATDLDPTNANVMTRYGLSRLIRFERLSNSEDLSTALAIQKAAVDLVDETDERLPGILNNLGNVFQTRFEHGGKVVDIDEAVNVHVRALYHSKVKEEERFTFQSSLGTAYHRRFEHLWDLMDLDASVDAKQMAAATVPKDHLYRAQLYASYGGVLLQRYGISRRPEDLEKSLEIQQEAVELTPSTHPARPLRLLNLARTLQDHVLLTKDLRSIEKVISITTEVIPTLVNSNSHRLALARLRLASALRMQYLVNKDTQNDICSDDLDRAVDAARQAVDVLSILPASLDMATVCQELGNCLLARFQEAESPSASDIDEAIAVLQKGAGFPSKPVILQISCAIQAARSCIKFRGVGSGIAAYKTFFELVPKVVWIGNDLHRRYEDIGRIRNVLSEAVAVAIQAEELNLALEWAEQGRCIVWSQILQIRQPVNPALGNLAIEMKSVTSKLQKMGMESKPMIKYPNKLTTTLMSALILHTSKDKPVPIEGMSREEYAHRLAIFPSLLHDANQQEQRRLAEKYENLVIQAQELSGSDGFLRPKRFSELYAITSQGPVVFINVCEERCDAICIVPGQKEAVLIPLENFSEEKATEILSSLIDDLEEKNFRAKSRGYSKLTARTEKICSILGTLWTDVVQPVLLKLEEHLVAENGNLPHVTWCPSGSLSFLPLHAAGIYKDNESCIGQRIFDHVVSSYTPSITALLAAQTQDSTQPIAAPRVLAISQPNTPNEDELSLTVTEVETVQKIHPDLTWLNDTEGTKDAVLMGIREHDWVHFACHGVLNLENPLQSAFLLQDGSLEVADLMKESFHHKKLAYLSACRTAAGSEKLPEESVHLAAGMLMAGFADVVGTLWAIGDDDATFVAEQFYRYLKEEGGGDSRLSSYALHHAIRKQRESIREDEFYRWIPFIHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT63</accession>
    <name>A0A8H5CT63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CT63"/>
    <dbReference type="OrthoDB" id="2982755at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="39141" checksum="B0C4A11DEC215ACA" modified="2022-01-19" version="1">MPQDILTMEAATDASFLFSGNSDLPIGAFIVTSLSGAIALATFLDHNPTVEVTHLLLSDSKADDLQTKPKAPEDSLRNHPAVVNHIVTRAAPTVRTFSYLLYQPKLLRPEGKRPTYAPLFFDNSFPRLRELTLRGVRLWGEEECGPDFYDQDPDEESLPACIFPSLHSVTHLHLATNFGYGQFPSSMSLRESMPSLSHLRLTAVSVPSELRTWRFMDNAEQTQTSISPNLTILYNPDFYPLFLFSDDHDTGPICGTPGVEYDYFLERLGEQSDRLGDKDQAKLRLIWPIEEDYKKYGPRFGIYPVDRAVNDFKVRVLREGDGAWSVPPLEERPWAAPGGQWWLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVJ0</accession>
    <name>A0A8H5CVJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVJ0"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="72"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5348740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="439" mass="47230" checksum="AE04A14C0FEFBA1F" modified="2022-01-19" version="1">MSDATIAETSEMTSSSTTSLSPSQSFTAPSFSPMPQNGFSDSPNARSKSITTTDLDTYGILNRHATKNTFFQVGVSEDKGSRRTMEDAHSFVTDFDNIRGQGFFAVFDGHAGKHAAEWCGSNFHEYLLKSLRESPNMTIPDLLNKTFHAVDAALSKMCEESDGKIHSGCTAVTAFLRIEDAQGKQSFLDVDSPPTADSPISAQNTNSNLDEMGSTHESGESSDDVGKDSKGSKSKKTTSNRIKKALRSLGSGSLSGSLSGSLSPKTPKSTSPTLSPKASVENVQVRLPPEGMRRVLYCANAGDARGVLSRNGKAVRLTYDHKGSDKQEAKRITDAGGFVMSGRVNGVLAVTRSLGDSSMKEFVVGSPYTTETELCEDDDLLILACDGLWDVISDQGAVDLIRPVQDAQDASRKLLDYALSHHTTDNVTVEVIRFKKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVR8</accession>
    <name>A0A8H5CVR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVR8"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122168" checksum="8D730046E852C09E" modified="2022-01-19" version="1">MSGAGPSTSAPHPNLRPGAFQYNGDPLRFHEDNGDRSRSSSATPCPPSPTPELDDEEEEDREHRPHQDNTTTFLNALAEMNANMDRNFDKLISALERSGHLTQATMTAASTRTSAIPSKPPKKTTLSKARPPEVNTFQKAIRNYLKKLLRRRQLVLDPTPNEADAFAATWDPKGDGPDCCDRDRFRIYLGGRPKHAWNVSAARVFADMMILDGETPYGESDRLKIQKAFLERVRGVIKDYRWAQEGLTQEEERKKLDRRKHRKSDLFQRRLRTVLRSDQLRQHKELMERLGVDGWLCCIESILEIFMETLHTNEFALEIWGINTSTLTGNSSHNYLGTHIIRTGFALNHSAYCSSILGQWKSNTNSFMTLKYTREWFHSQEMPDTDMSHMKMAGFWGKSEINNLVNQMHEVMAMMADLDPPYVLHSRLTLRDAIDVCALAFSPRGNLLAAGTKSGLLRIFALDNKYLPASFQLSSAITALIWGKDSNTEMLFIGEVNRHLHYVRRSLTWSAALSSQYDPLITMRDLQGPITALEISNHVRLLFVGDGRDIVVFPLDNINRRGPLMTQSPPPEKEDLAAVISGLKVKDGPEEAVVVVGYLEHGIRAYNIHRDTVANITSLNLCWTLSERRGHYFVSWDVHKRQQYWLTVVYNLYDGIELYWTDPINEPKTAQYRGQLIPTTGWGHRNMVLPVGILADGQWLIYGGSEGNTFIIDPNTGREIQRLNNHGDLGCSVFCSAIWADNDNGVERIALGTTGGLTGSITVYEYRDTTPRGTPLLTSPSPARSPKSVKIAPATSSSASEYPYPSSDIKPPHQNQSWKSASVPLSMIGCFVVVIMASIAIAVSYYGSPMTSRHEVVSQQVSKPTSSDTVTVIVSPQPTSSDTVTVIVPPHTTTHTMTVTVSPVIVSPQPTSSDTVVVVSTHTMTDTTTVTVSPVIVSPQPTSSDTVVVVSTHTMTDTTTVTVSPDIMTVMVFPKTSVLEDSWEDSWTCSANNCPTTETMTVMIMESATMERQTETVSVMVTVSPTMDLHDFSVALGSSEWGQGISRAIQKVCDEIILLKERLDRAASRTGDWGTNLMIALLLVGAGAVVTLLFLCNAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWJ1</accession>
    <name>A0A8H5CWJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWJ1"/>
    <dbReference type="OrthoDB" id="3030888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="326" mass="37436" checksum="50FD6F716D25D11B" modified="2022-01-19" version="1">MTHPSNLQSISHALDTWVINDDIVDDLEERQAAYHDPDSNTWRKRKSRNELETYQVISPHPRILPIIGIDKEGYAVFKYQCNGDLWRFLAKNFSTPSNVPITTRIVWAVEIAQGLAHLHHKKVVWADAHLANILLSDEGHALLCDFAFSVRNPKFFHSFRTVPPPIFFCPKTYYGIQPTHVDIFSFAIIFFVLLDYRFPFTEDVTPNQEVQDNTVDKHIAKQFDVLRDAVLHKYFGEILDDCFHVRIVTGDVLVQRLLDAHAKWFSETGQVVKPDVSFPQEPEIIPIVPVPLMQMFPVNGENGWSHAEDDSSDERLQRGSQSEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYQ4</accession>
    <name>A0A8H5CYQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYQ4"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034550577" description="Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="344"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5349042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="60151" checksum="5C5516F424DF75F2" modified="2022-01-19" version="1">MISRVSKMHPLRLCLGALAVMSFVSGISVQPSSVGARAVTSNPVLYEDFADNDITRVNDTYYFSASTMHFSPGAPILQSKDLVNWKVIGHSVPRLDFFDDNAYDLVNSTAYIRGIWASTLRYRPSNKKWYWIGCVDWVRSFIYTADSPTGEWTQAGVINNCYYDCGLFIDQNSNGGGGDTLYVAYGGGNNLSVAQLDAAGTAEVSNKVVWSYDKGREGNRMYKKDGFYYVITDSPDEGSQLIVRSTDPFGPYENRTFWSNSIGSPIAGTGAPIQGSLVDTPDGHWYFMSFAWAFPEGRSPVLAPVTWTQDGWPQVTFNNNNWPTALSFPLPASTGPLQSWTGVDNFKSIGVEWEWNHNPDNSAWSINNGLVLKTASVTDDLYAAKNTLCHRILGPKANGTILVDISRMTDGDRAGISMFRDLSGYIAVKQDGSTRTLVMRNNINLSASTPGGTCCWSTSNKGNDVTTASVTGNQIWLRITADVAPTGSNQAIFSYSTDGTRFTVLGNALVLDNSWQFFMGYRFGIFNFATKALGGSVTVKSFAHVSARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0D0</accession>
    <name>A0A8H5D0D0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="392"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="686"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="912"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1538"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5351291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1560" mass="174347" checksum="A0803BDEAFE6E956" modified="2022-01-19" version="1">MNNDDLDDLYDKVWSGYDLPKSPSRSRSARPLPLPPTPSMSNSPVSTLPPSDYNFNPSRQQSIESFPSSTTTRQLPTPKSNGYGSPVYPDSPVSYTPVRPPITDYPPPPLPTHTAEWIASQRKSYQPVASGSSHGVNGDSIYTHPGPPQDYTYENLQPPDDIVVGGGGEDQPYDEDDYFWEDEEEDESRFVNFSLLSHIAVQLKDKVPRGTHVKGSIPYPRAFTGRDIVSTIQSLIQRELAINHDVSTSDRRAAIQVARSLQSQLFFYEVEWGGRVLQDGLEDVYMFLDDPQDGPSGSGGGGGGNERAELPTGVVTALTKCYSPDCVEGSACYSPRCPRRGDSIIGPIQGTDPSSQSQSQFPYQSTSRSTREEWIKTVPRQVLGSLPESEINRQTIIHKLIAKEEQYLADLDCIETVFIRPLRAAALNPPSSFSNESSNPNGLNGPSLNPTSSTPNGPPLLPELDDFIDIVFSNILDLRECNRRLLESLYVRQREQFPVIQRIGDLFLEAASEFRLAYPAYIGGLQQAEKRLREEMEGNYEFRTWVEHCSRQLSAQSTSPDSSSSSSPRLLDLKHYLTLPSSHLSKYPILLEAILHSTDQAKDNTPDAGPSQASSSTSPHHQAEFGNPDASYLTSAIEAISNLQSQAQLQTFQNAMGAGVPGKWEWHDLVGKEARVMLGLDKKEVKRQAIIFELIKGEMSYVKDLENIEVMYIRPLRSADPPIIPPDRLDSFIHDVFHNFAELHAHHRRLIDRLHEIQREEHPIIRSITAAVFDSALFFRDAYIEYIPNYPIAAYRIDDEMASNPAFKGFVENAVRHPDAHRLDMKNFINRPIPRLLRYELLLKNILDETPPDHEDRDDIPQVLEVIKALGKDSEPGVVSAKQKVELWRYNSNIVFKPGEWIDMDLLDKNRSLIHFGRLLRQPDSGLEWNGWSELFVLLFDNYFVMTKAREKDGYTKYYVNRRVSTNYKYTSKYDPYYQPQPIPLDLLTLVNFTDPPTQRGAGLLRNLRGGERHNTAPSDPTSLTLGSSNSYNTKSPDLPTHSSSSIPTTTSTPTDSRSVYPCTIHHNGRMGGPYILYAESAQVRAEWKSKLEEALGLRKAVQDNNKVFEVETLSNDTFLVPSLMNGSGAGAGGDGSGSGGSTQAWNQNHDNTFTGKVTCTVPLNTPDGRGLVAIGCAEGVWIGFRHDSRSMRRVLHLKMVTQCAMLEDFGIFLVLADKMLFAYHIEALVPSSPSSTHATQTPQKLSGNKDVHFFSVGTLLGRTLVIYMKKKGLDSIFHVVEPVLDKINERSKTPASLGSRFGFRSPKSEWFRNYREFFLPSESYDLIFLKAKIAILCAKGFEVMDLTDLQSATIPQREDARHAPLAKRWESVKPLGMFRSTDEEFLLCYTEFGLYVNKHGDPSRPTGSIEWEGTAERVALHNPYILLFDTRFIEVRHIQTGRLAQIIPGNDVHCLWDGRGVNISANHPFPGGPDEQMVQEARVHGVMTAPNSVLKNGTGARSIKGAVAQHVFELIPTIPLYLPGSLASPSTATYFPQSFSPPHSPTMRPSLRPTASYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1R9</accession>
    <name>A0A8H5D1R9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endo-beta-1,6-galactanase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1R9"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL/EXGAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767:SF1">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034661216" description="Endo-beta-1,6-galactanase-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5352040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="794" mass="85596" checksum="DE7DFF9626F07174" modified="2022-01-19" version="1">MSPTYRAFLSVLAVSALLPHAQTATISSTPAQTFLGIGGSGAWWPNDLFQFPDSVRQNLSSLLFSQSGLGLSSYRYNVGSGGVGVSNPTRAPQTFYVSPGQYDFTKDAAGVYFLTQASKFGVHDLTMFANSAPAPLTSAGTSCGSQFKNGTGSAYGTFLAEVTQHFRSQGILINLISPMNEPDSSFGPTPCGQEGMLVQPNQRAEVVNGLWNALNALGLASAVGILADESSQLAFATSEYSSWLPQVVDKVAALVHHTYDFPSDSSYSSFISNEICCTLGQADGTGKGYSQGYDPTITNALLFSGLVFQSLVVAGEPHYDFWTLVSNGIGCDPSTDPSCATRTNGNGWNDGVIYYDPNFARNGNHGLYIKKQFWTYKHFGNFVKPGTQRLPITGSDSTTNSMLAISNSTTIVIIAMNTRTSDSTLSLTFPANVCARGGFRTSATEDFASIASATGSGSSWSLRLASLSLKYSLFPLLSIPMSEIHLREVDSFHCSPKVKTPPKTSEIPTPFSYIPSDDGTDENLLILLHGLGVYVLRANYVLNQLPVNLGDTHIPFSKLGRQFKLPQTAVIAIRAPEQVPFLYEEAYQWYTSFDPLGELISRPNPTPALEFLSKVFDHLTDPTQCAWPPNKIHLFGFAQGGSVALEFGITYWRKQLEQHRKAITAATTTPDEEDKGFTSANNANNTTSTKPIASLGSIVTITGPLLSYPTLSSPSPTPILAVYRPPPAEPSLSSGDLTAIKKAYSAVKEVKLGPRGPGMPSSQEEWEGIMRFWSERLSRRPGDGLYEVMSGMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6P5</accession>
    <name>A0A8H5D6P5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6P5"/>
    <dbReference type="OrthoDB" id="3227715at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="354" mass="37354" checksum="4F81104FA7245BD3" modified="2022-01-19" version="1">MPETNANAQNGDKSFNSTSSSPNPDSVGNDYTSISDSELSQADFEKKCSERIGLRKMTPAEEMVVHDPLLKRPESVTELEATHNRILSNLRSRISTLQSDELFEQTLFKGPQIGLEETPIPNATALMSGSMSMTWSGLGLGSQSQSQSRSSWANPGVQSQSHMHSHPHLIGGRPTATTTAPGPGPSLPLPTNDIDSIMRSMMGPSSLSVRYDPYRNATYRHGHEDPGSNGLDATETETVADSDNEIRTQTQTPASSSATTAPSTVQPVSSQPPQQQQQQQQLKHKTRFAALPIPDRPRDKEKKGGGMDVDVSSSTSGSGRIGGEKSAGGDGGSGEGGGRGGGVGNSRNGIGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7E6</accession>
    <name>A0A8H5D7E6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7E6"/>
    <dbReference type="OrthoDB" id="2970804at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39183" checksum="86312DBDBE32E16B" modified="2022-01-19" version="1">MSSTPNSITPCAKCSSVDHDFQACKTFSFAYDPSSTTDCQALVEYVPPFPAPTPTLSLSCHNKSDPVSILQEGFRNPFLRLLIWYLFREATLSKPLTDDQMMNVPDDEGGECIIKFTPEVAARILEELRLLAKMVVTAATGLGNPNNSSPPSIPRDVLELEWSDSPLRNVFPHLSLVLNPMDRTILDAHAKSRQGLQEQYAILQFVARQYARWIVDQVLRSIRKGYLSECNWGAIFGLTQDETLTLLTRRSLQELEIEKRRVEEKKAMSIRGRESRRKALGVDDEAARAGALILHPTESTMAKQGLLAPYDPTNPGWTTDVYSLSTEITEDEEDWEDVLKLVTEDFGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D965</accession>
    <name>A0A8H5D965_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D965"/>
    <dbReference type="OrthoDB" id="3027122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="126"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="492" mass="55209" checksum="882B5AD87589EEED" modified="2022-01-19" version="1">MEKKQAQEMTDTHTRNMEVSAQRSQAIPNAIIAQPEPRAGVDPIATAQNHMNPIRSNPILRPGLADVSILGQARNFSVDHTQINAVGGDQHNTQNYFGEQDILNKLDYTRAAFHDVGKRSTCTEGTRAEILQNIMNWAEDTSPDTPAGYWMCGMAGTGKSTIAKSMCLMLEKKGLLAGAFFCSRQIKECKDYHKVIPTITYQLARYSASYAIATREVLNIDPDIAFKEPNSQISKLLINSWKSATSSYTPVVVIDALDECENISLVLKHFIPAIRNQEIPGLKLFLTSRPEQHIQDHFNVDTMQQERQTLQHFYLHNVQKSIVRDDISIFFQEGLSEMSISKGKMDMLVESSGVLFIYAATIVKYLTGGRQRAQSRLKNVLNLKRTPDKHQTEILDELYSQILNEALSLSKLSSEEQEQSLKVLHTSIITGQPVSCQILSELLDLDLEDVQATIMDLQSVLYINQSDQAVYTFHASFVDYMTSEARAKKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F1J9</accession>
    <name>A0A8H5F1J9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000415">
        <property type="protein sequence ID" value="KAF5320201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F1J9"/>
    <dbReference type="OrthoDB" id="5076166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5320201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="26658" checksum="A50A0478C97F0D65" modified="2022-01-19" version="1">MEGIFLSHPMTKGRYQAVDSIVGHEHMLMNQAKSSILERQWTKEYRTVYKVAGALGEETLIVADLLALQRILHTGGYNYPRTPDERATIKRMFGKGIVCAEAANVFQRQRRNLNPAFSATQLKSFLALFQKHSQRPIQTWKDDLSSDDTTNVSTSKVYDLVAWIPRVTLDIIGENGGAGLDGQGWLEEWAGLAGGVGRVGWRSVQGWEESWAGLCGQGLVLVDDQGGMHASYQTDLKCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAN3</accession>
    <name>A0A8H5FAN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000341">
        <property type="protein sequence ID" value="KAF5329906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAN3"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5329906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="704" mass="78070" checksum="2F098973B38BCDA1" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPPDPLFQNPLPFPLDPIMSDAGENARTDVRDTAPTPPSSPPSTSTSSVALSMPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFHINNAIRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYIEELDAIELINKLKQCFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAAPFQKPSDVKKDQKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPTSSSSQIATTSTSQSDWVQSISSGDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLRLAGDMRVEIRKDNARTSKLTPKGKRGVWNTNLNQMDVDEDETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQPRYLNDPGEEHYAAAKQCYLYLKGTCDYWLNLGSPTITSTYGFADSDGMSTYGNKPMMGYAFKFAESLISWSSKRGTLVTLSVTEAELCALAHASQEAIYLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDV5</accession>
    <name>A0A8H5FDV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000299">
        <property type="protein sequence ID" value="KAF5332922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDV5"/>
    <dbReference type="OrthoDB" id="3047765at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
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        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
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        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="962" mass="103582" checksum="BC64C4C34E13C4B2" modified="2022-01-19" version="1">MSSSNDITPAPPILATPVVNSSVPFDVVGSRDKRLQRTQSRVRDRGGIFKPTPRNTLLDILLGKQKKLSPFKARRSRSRSRSVSSSPVRRKSGAGAEAAANPIEGEDGEDDEREVSKSKAKPKPKPKKGRKSVRKSMAAASLELELELDEEPVAGPSSPVVALTKRTAASASTSRKGRKKAGGSSSNSGAIFSNKIVDAGPKPEPKPRGRKPNSSSKGKARAAEEVDDADADDPDNEAASDVEAESSKATKARTKPKPKTTTRKRNPTSTSKSTSTASTSQSTNITGTTSTTKKRSSASTTTAKSTARGKGKGKTDVSEDVDAEVDDDDDPPVVKPKTKTKPSSKASSSSTSRASKSKSKPNSQSKTSKPDSSNKKTKLQVQSPPSANAKSRWPLWAIVEEDEEEEEMEMKENTSINRQKAEIDVDAGDEVDGKHEAAAQQSKEGTAPESKSKSSKGKGKAKAKPQAEQKTAVTATSRGRVKAKEKEGEVDEDNDDESRTKVSQKKTRGKGKEKEEQVKGKRQTREAEVPKTASGDDDEDEDEAKSLPQPSTRRKRIAAATPKATYVEHADDDQEDRDEGEREASKSKDKSKSVSRQRTSKSKTVAVGSVAENLDEVTQVQTQTSTQSRTSGEEQAKGKGKDKALTSNSMSQIRNRPVTGHDEDDVPMPKAFQRSEREKDKEGREYVKGTCKEKEVSQGVQMREPQIEPEAEAESSRAGKKKGKVKDSDAEIPKPKARAGGRMKTESFVDQSKQTAASTSSPSSSFRPSKRPREDFAEDLASALNKKAKVDHDFLPDSHTETSTDERKPVKSTSKVSKTVSETLMATKTTASKKRRLVDQKLDAPGADGTGEQNDAEPARKRKKTTTAAAKASKDDSNGETAPLSGVKAGAKPRLKPLSRKKKENASSPKATKSTSSRKPTSKSSSSLKTRGPPKSILEQVRKTANVHLLGDDEPDEIDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FER6</accession>
    <name>A0A8H5FER6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FER6"/>
    <dbReference type="OrthoDB" id="2901006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="30584" checksum="A6847CD65CF5A612" modified="2022-01-19" version="1">MVPSRIFSQHEVMHHRLPAAGRKDVAASLVGALFRVHGRVVKTRSGDRRLHRFDSRNGNGNLTRDSSDSSDTGSAYAIELNSDPLTLQPLPPSGLATYTSPLLPADSVDHNLIYVSGNTDTTLRGKNIVVDDMDVYSEDPSGTGNGGTGGLGHVLQYKGNWGVLSPKTFVLDNQTPVQSYMNTTHWAWGLVISVKISFAGTSISLYRTIPSSSSTASSTSSINDGNITLSYTLDSNSPINLTLPLRSNSDTPIPLSKFLELEFNPLYSEQKVNGRYTRWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFA3</accession>
    <name>A0A8H5FFA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosine-purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_016322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000247">
        <property type="protein sequence ID" value="KAF5335050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFA3"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5335050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56472" checksum="41864713D32344F7" modified="2022-01-19" version="1">MAQTDLERYLDPSELIPEKGELAENEARSSSESSSRWKRVTGKLLTWGVETRGIQPVPFEERTDEQFFKIFFLWFTTNFGILSFSAGTLGPAVYSLSKGDSCLVILFFNLLCCTPVAYFVTWGPKLGMRQMIQARYSFGYYGVIVPSILNLIGGFGFCILGCIVGGQTLASVTDGRMSWTVGIVIITAIALFLTFCGYNVLNWYDRLGWIPVLVCFLVALGLGGKHLSTPAPAEPATAASVLSFGSVIAGFVIAWAPMASDFTSYYRPDVASWKMALYSYTGLMLSNAGLQILGAAVASVAPLIPSWNDGWNLGGASNVGGLLQAMLSPVGNFGKFLTVLLSLSVTANIATTMYSICLNFQILIPKLVVVPRYVFSLVATAIVLPLAIVGSHRFYDTLENFLALVAYWVSEFVAIVLVEHFVYRRQNQTPDLDISYSTTMGYNITQWNRPSQLPTGIPALAALVLPYGLITPSMNQVLFVGPIGEKTGDIGFEVAFFLCGLLYLILRGLEVKWRGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGJ4</accession>
    <name>A0A8H5FGJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGJ4"/>
    <dbReference type="OrthoDB" id="3236755at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34369" checksum="4A41F3EF79B945A2" modified="2022-01-19" version="1">MKRHVYLLEVRYATDDTHTAQWIRGLVKPWIEKIGSECFCAACSNSTGNTLLARQLLHQDFPHILSVANICHHLNNTSKDIVKLKFFDVPIKIIRSSLKTFSKSHPAKSALKVARCQKQTGPSLEAIGKTHFVTLTLSAISVCRTLPALQQVFSTPQKFDFEYKEYFQPANHKLKARKFEDDLEQLVAVGLPIAKALACLESNHANAADVFVFWHAEVQDDILDILNQCTAQLFTPDGRLYNGVYLVTVYLNAGYLSSDLLKDNNVNPLTPTDSTTITCLEEIGIHHPLLYCFVFKYLAELASNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIA1</accession>
    <name>A0A8H5FIA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000205">
        <property type="protein sequence ID" value="KAF5337814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIA1"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="218" mass="23609" checksum="6F8E753CDB034CAA" modified="2022-01-19" version="1">MQAEYAWMNRDGLIPATHSVGPHPFHPGKGGKPKKKKKKTQRKATDYYDVSDPFIDDSELALDDRKYFAQTKQARFYVSSGEVALLKDKSPVKKPKSKKAPVPLPLTIHGHNNLSTPSLSSHTTSVDVGGTTLSQSHGHSHNLTHVYPNPTPSSSSKHTPIHIPFPKANPTTLTTLTSSTSISTTTSTFKGCAASYSWTGCSFWVTRTASSPSPPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIA5</accession>
    <name>A0A8H5FIA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000219">
        <property type="protein sequence ID" value="KAF5337438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIA5"/>
    <dbReference type="OrthoDB" id="3034442at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="668" mass="72714" checksum="C2E866E63FFD1AB6" modified="2022-01-19" version="1">MCYAGQCQTCRRLNELSRLPIIWIEACHSQILSKGYPFPRCSLQELPQERLETLTRRAYRLAQRWLNQYHNVNLDSGRKPSLSSFSSSSSTSPSSLFPNKECKFSVSPSAPIADVRFIEGFEERFLLTVSKGIWSVITIWDVAEALESLSGQGSRNGDSKSTATSYRERRPTTPRKCCEWSPKGGLFTGLTLNSDLESEAKLAVSVAFESGQQIQLMNLSTDGQLSPICSIDVAMKPMTLEGDFIAMSDDLAQTTIYNWKTGDYAILKHLQDQEGVWKQDHCIQVVFAHQSILVVRARSVHLFPQPVLRPASVNAPVYLPIARHTFGWIDGVSVVPPSRIRPEVKAMGTTFPATGGYGGGLEPRHDFDDGYSESASRDSFDLPPPLTLLVRLQSDNPWTADEHSLDLYALMPSADAAVKSISRYDESNESQVRVLNRSHTHQPPPSVLATTPTLTVDADTVIPTLSDASATLSSSSSPPLTIPPPPTPYLFPPILTSRILSIRGSLRCTDVVLGPCRTAVWIRPHDRSLGGLIDDSLNGLTMMGMGGLMGVGSSQNVDGGDSFNNERSKEGLVCAVFPGPLCPSTSHGARMSSSSSSTGSTGSEDWIGGVSTMSVNGGDGEKGERDSDGGVRMMWMNELNNWTTLDYYEAMGRIALGSGDGYVTVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIC6</accession>
    <name>A0A8H5FIC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIC6"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="388" mass="44018" checksum="D656A9492699DBF9" modified="2022-01-19" version="1">MSENPASATAAAGGTQAPRDAAPPDDDAQSSVFPNMTTKERGVKPEKFTGDRNQMKDWMAEFNNYLRLNDQVYPTEEEKISFFLTLFSGEEAKRWAHNMMVKVFEEEDDFSDSDEEYTSTDEDSSASKPKTKGKSWTLREVKQEFLRDFKPSARETQAQTKIEHIKMEGALADIDKYNSQFKRYADNTGYNDKALMKYYRKGLPRGLVDRISYLSTQPRNLAALQKAAVKQHMIWLERQEEKTSWSKPRREEGQPGRGPQGTRSGRTRSMEVNAFQDNVPGASSTIKYPPKLTPQERDKMRKEGRCFRCRGQGHMGNDCPTFPNTPPTTPNNTTWRPSIKKTAVVTETSDPKVNTTTDNISELTARIGALSGEEKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJG9</accession>
    <name>A0A8H5FJG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJG9"/>
    <dbReference type="OrthoDB" id="2142724at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="121" mass="13783" checksum="3A29C89AE2CEEA3A" modified="2022-01-19" version="1">MFKDTVDTDIFVTFLREQVAPILTPYPGPRSVLMLDNAPIHHAEEIRALVEDECGARLIYLPPYSPHLNPAEQAFSFIKSYLKRHENEVVDQDSRIDVIHRATQAITSDNAVAWIKDCGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJN9</accession>
    <name>A0A8H5FJN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJN9"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF10">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN YAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5339284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="369" mass="40134" checksum="A4ADD550F35C17D4" modified="2022-01-19" version="1">MASAQAAIYEAVYSDVMVDEMLVRGVAVMRRRADFYVNATQILKVAGYDKSTRLRLLEREVNSGGERMQGGHSKYQGTWVSISRGREIASESGVLPELAPLFDYQANEDSFTAPAASLFLPLTGSYCHETLGAPPMSSDVSAVISQLRVAPGTSLQLLRECRERGLFVLSASNPQQYRSPLSFTPPQQDESFQPSKLHSNPATTRIRDLSNKKPTTTRSSKQSRSGSTRFASKATPLQEATNVHQSPTGADGSDAPPSKLSNKRPLPTSHPGYPRNADVILNFSPSLKPCQPATHLDPAQTSSEDECDSSDSEEPEPEAEFSGYTDRNGFPDATEGCRSIVPVVVDLLRSLPVDEQSMARFSAKVEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKT3</accession>
    <name>A0A8H5FKT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isomerase YbhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKT3"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="38671" checksum="209875819B773179" modified="2022-01-19" version="1">MVNFTILAGGYDVFIAAYLFNSDAGSLTVTGSYPSAANPSWITPGICNRSIFYATNENPAGGLQSFTVTPNGVVSTAAETISSGGDSPAFAAALSTGQVAVFNYNSGDGRIVPLTDGGLGFDDSASSAALIKFPVPTAPTSEGVSHPHMALEVGKEIFVPDLGGDMIWRLSQLNGKWEITGSIPQPPSSGPRHIAVHDDRLFTLHELASTLTVQAIPAFPNGTSQIISNVSILPAQRPPNASYAAAEILIPKTTPKFRTPYIYVSNRNVGIQDPSGVGDSIAIFELVKKGTRDEHLQLVKQVFTGLDQIRGMEIGFEENGSDEFLIAAGVAGNAGTVVYRRVNGGSDLEEVARNLDIPTRTSFIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLB6</accession>
    <name>A0A8H5FLB6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_017064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000172">
        <property type="protein sequence ID" value="KAF5340827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLB6"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="6">
        <location>
            <begin position="261"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="814"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="848"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="885"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="914"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5340827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110220" checksum="88A17AC51415413E" modified="2022-01-19" version="1">MNDPQSQRKIPPSVPNIPQPSEEARNSLSDAEKGQAGIGRRQSSEKSSAPAADRIGNEKGKGKEPKSGPSQSVPASTASVPVKPGSAVQHTGGDVGTTALPQSVGHSIHSNSTATRRSSNAQDAQTDSEVRNVMEEKSKSEPMANNNTKDDAPPGVSGEPNSQETDKSSEGSTVPDNLSDSIARIAKGLDVLLSLITEGTDNSENAQQHVNETEKKKGKFRRLLGITEYQSPYTGTRDYDYTRKYPQDEFGKEARENARVWKVYLDEAETFDGEMLKGFMDTLDTLLVFAALFSAVVTSFVISTVVNLQPDYTEITARLMLEQNLLLRATGNTTAQQSVPKTLVDLDNADVSTKDLWINGLFFASLSLSLATALLSVLVKQWLQAYTLSLPTGNAQERAKIRQFRYLGFEKWKVPEIIGLLPIILHASLGLFMVGLSVYVSELHQSLCWIVVSVTGISFLMYFGSIIIPVIHIQCPYRVPILFSLLHLLPFPLSIFQYFWKLVTYHGQKYYHHSQSNHLQNLSQPKLPSAPITSLRNAETMFLKQTPPTFNFVTFQEEISPSSTQHHTMLAYCLKWLQSLQSNDSIQEVVHQAVHCVFQDTAHNDSEGGIYGFQPALKCYVALDWNSIQAFIWDTLRRRDETDNHKVCSSLYSLWRKAIEKISDFPPLQTRYPLHDAAENGYFHIVKVLVENGIDVNAGEGFYGFALQAAALWGHLDIVKYLVEKGADVNAKGGPHGFALQAAVEKRHLDIVKYLVENGADVNAERGQYGFALQAAAFRGHLDIVKYLVEKGADVNAKGVSCGEGAGVNAKGGEYGFALQAAARWGHLDIVKYLVEKGAGVNAKGGEYGFALQTAAASRGNLDIVKYLVEKGANVNAEGGTYGFALQAVAEEGHLDIVKYLVEKGADVNAKGGEYGFALHTAASRGNLDIVKYLVEKGADVNAEGGEYGFALQAAAYLGRLDVVKYFVEEESVDVNGKGGKYGSALKSAQEGDEPEVVKYLREHGATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FND6</accession>
    <name>A0A8H5FND6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000147">
        <property type="protein sequence ID" value="KAF5343166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FND6"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034914426" description="Amidohydrolase-related domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="94"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="367" mass="40557" checksum="1AD79E458269C7CB" modified="2022-01-19" version="1">MRLIPSSLALLISISLLIASPCLARRTWNDTGRGTIAFEESWATPEIMGPLSAVYPELLADLQDVHNQRLKRMDENGIDFMILSCATPCIQAISSPSLAASTAKSVNDELASQISNNTLRFGALAALSMHDPVEAAQELNRTVKELGFLGALVNDYQQAGDNNETLIFYDSPQFDPFWKMVTDLDVPVYFHPRVNIPLVFNLSYGHAPFLIGPSQEFPATLSTHVLGLCTNGVFDRFPTLKVIVGHMGQRIPSDLYRIDSRLEFQRRNGLSMKQTVRSYYHTNLYSTTSGDFDTSLLLFHKSQIGLDRIMFSVDYPFESIEEASGWVNSLGGGKGNNGSKGGGNALTLEELLALKRNTAIKIFKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNX7</accession>
    <name>A0A8H5FNX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNX7"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="930"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5343452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1273" mass="133862" checksum="9C819A313FB2B10F" modified="2022-01-19" version="1">MPPSSSKTSAPPPSNIFDDDDDGWEDMPVVREDELRGGLDEEDQKKYHYQPQASSSRKTNTVNATGNLIDFDDWGTEWRSKLDTDESEYTRLRGREEDDDDDDVHLRTKYLFDEDKAMTPLSQMQQTKNMLTEAQRIAYVGLCALTMKEMLGRLKKGNRKEVKVAAASMQLWSMKIMGRLYYHMELETQEQKMIESLADHGVESMDLVPALMTTHTVANPEYDPAEGKKKADEDARVVAEAKAEADARPSSPTPSTTSTLVNPSPASPSSPNPNTAAETPTTPTSYTNPTYQTTTRILPATTHPPTNPTANASDSLEPGTVSTSLPTHTPTLILDIRFTILCDLFLLLIADSHYDSRSRTLLESVSTKLGLGWVDLVKFEARVSEALEIQEGVSGTDESAKEMVDTRIKSEKRKRYMLMGLATLGGGLVIGLSAGLLAPVIGLGLGTAFGTIGISGATTFLASAGGAAVITTGGVLTGSGIAVKGMANRTKEVRTFELLALHNNKRVSCILTVPGFLNGPLDDPRLPFSVLDPVVGDVFSLLWEPEMIRETGSALRILTTEVLTQIGQTVLQATVMATLMTALQWPIVLTKLGYLIDNPWSNALTRAEAAGRILADLLVQRHLGVRPITLIGFSLGARVIFYALLELARRGEKEKESSKKKKGVTEGTSVYGIVQDVFILGATVTASTSSWYKTRSVVGGRYVNCYARNDWVLNYLFRASAATGAGGVGAVAGLRPVEGVEGLENVDVTDKISGHMSYRTFMPLILDELGFVVTADFFDDPVEPDFEGDRVVVREEADGDGKKSGWFGSKNWGNKRNTMATGHVQRPPSTYTGPRGSMSSTGTKTSEGDGKEKTLNEGDDDDDLPPRMSLDSDTGTPSKGKTKTTAEASTPDSGPGSGAETPIAATPNLPPKHAGFDFAAIKELLNQDLDATEGDGDGTGKAVAGGRDVLFDMPRTPSSGGFPSGSGSGAVAGPGVEGVGAGAVGTGSGGIVIPPPTNRTESLPVDLPTISSDTDMDTAESDTHTPRSRTPVAVAGAGVNGLDVPVEESSLVLAKGMNRSLSLNDAPLKKATSSSSLRGRNSGLPSPELPRTPTSPLSPPPPPPDKDKDLDARSPPSVYQLPSFSSNSNGFSSPLPMSEPTLSFGGADGSIWGSSSSSRNDASLGGLSRTSASPLNASTTSLAYNPFASPGPSSSGFDPGLGLGAGAGLSFGGADGSITTSLGDAGGVGGGFGGGFGSASSGSSSSADPWAIPSDLGLGKKRTAQGLNSNPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPF6</accession>
    <name>A0A8H5FPF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPF6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="44197" checksum="A2E786DD652F80CD" modified="2022-01-19" version="1">MFAMQMPCLLKFGRVRSGRWSRLVSGQGLGMICVGRWIRMRRSGFGVMLEISIGIPNEEHTGAPLNKTKVYPHTETWRKLPMHKHDVVYAEFFPWWIALWIKLPYFLGISSGQKPTSDGSRYPILLGTFYSSSLTTFRSFLTSNKTPPSSKLSAPTTFIRRPFTTMCGSDTLRSPKHGRYCVRFQGSRLKSARNVLEKTVWRWAGSFVVWIVHRICGGSGIPIWRRYLSSLLVLATSVKLQSPRAQSPFLVNSTIRDTLSPFTMIIHDAKEHSNTPQPSLQAHFRTYGRRRFIKLQNPRRTAYDIERFLSLIGRFWILYWSFLGLGLRWWTVLGDGMDVCGGILSRCHLSFSSSPSTSTSRTFNFFLTNITSDKTVAVEYTGDYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZB3</accession>
    <name>A0A8H5FZB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZB3"/>
    <dbReference type="OrthoDB" id="3229610at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5354494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="347" mass="39249" checksum="F9CF3AC58855D78C" modified="2022-01-19" version="1">MVASPTGNQIRLAAVIGIPIAVVITWFRLFLRTKTRKLWWDDFFAFLSMFLSLFFLTGIIIFTDPPERHHSQVVKVFANYIIDIGFYGAIWPARVSILLTLVRIVIGRFRTMLKYMVAAYLLTWAILAAQGFWTCESDNAWKKQEVAQCVLGKNIAIAQLITDCLADLCLIAAPVYLLSTLNTMRGLRIRLMIVFSSTILITVFSLVHAYAILHQLGLLEFMFALLEVIVSLVVANLSVIISWVFKLTDEESTHYVVNTFLREGRSGGRRSNRRHDLTTLGTLTTFTPAQVEITREVDQDTTFVEFDKSVAGAERIELPTVSSEELHIDDGKGFKRNLEHPYADHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1F1</accession>
    <name>A0A8H5G1F1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1F1"/>
    <dbReference type="OrthoDB" id="3221235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57940" checksum="0052B83782839CA5" modified="2022-01-19" version="1">MTTTSAAVSPFLHLLGTNYVASHEEKVVISELLSAPLQNLAQLDSKIHKLESVLDDLKRERNDIQAYVSAHQALVSPVLPAEVLSKVFVFCLPDGRNPTRSLNEVPLLLGRICRFWREVSLSTPELWTAIHVVIPVNVNIDAKRLCSVIDARTRGVQAWLRRSGTLPLSISVYSEKAKLLRRDYEQKWISSRVARLLDCVVEVSSRWKDIELCMDYLLMEGWWAENDGGSKDFKPGNSVHLHSLSLQNMNYHYLEERFPIAQLTHLDLRKTSREGGLSIQGGLSVLSKCKNLVSCKMYIDNSYSGIHNRPSFSPPTHFRAWEKIISCSQLRLLHIESEGGGADAVFGFFFQHLEIPVLRSLGCEVAAYRGERAPFLSLLTPDNQVEELKINLPRLPVEALVECLSFTPNLVAARIIGAENALFNQREASSGAGLPSYCPFLKKLVVEAVDASLDDEHLLAFARSRRNAGTLEVLHATVRSLKGEASEEQIKDLRETGMDIRIIYPAEDWDSPSSGVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Y4</accession>
    <name>A0A8H5G5Y4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AFG1-like ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Y4"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59472" checksum="F97DFF2CE4E6A396" modified="2022-01-19" version="1">MKERQKVSLFIAVVHNAANSRVFFRCFSVPFLRFTPTTMSLNVARNVAARRVPRSLVKHTSRRLSLSTSAKAHNSSLATQSSTASVESILSSSQSISSLQSESSGSSRHHTNPLQYYHGLIESGTLRGDEHQTRIIQKLQDLHDKLIHYVPPPIADNTPSESLFSRFFSKAETETAGPPEGAPNGLYLYGDVGTGKTMLMDLFYSTLPPHIKRKRRVHFHAFMIDVHKRLHAAKIAMGYKGGDPIVPVARDLAREAHVLCFDEFQVTDIADAMILRRLLEGLLNYGVVCVMTSNRHPDDLYKNGIQRSSFIPAIELLKTRFDVTDLDSGTDYRRIPRALSKVYYHPLTPSNALEVQKIFNSLTSQDPNDPPIPNRALSIWGRTLLVPESTSKVAKFRFDDLCGKPLSAADYLEVTKTFGTVFVLDIPKMGMDRKDLARRFITFIDACYESKTKLFVTSEVPVTQVFAGDDSSSNSKPISDHMRSVMDDLGISEQIVGKSSMFSGEEEIFAFARACSRLVQMGSKEWAETAGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8G1</accession>
    <name>A0A8H5G8G1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8G1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="168" mass="18628" checksum="84D2B07D3D5012D4" modified="2022-01-19" version="1">MFVKLVPMIFWSEKRHDEEKCCNDTRRLEKEEIALTEEEDQELLRRGSERHPDTALACSVHAAKARKLACATEMCPCPTEPIITTPLQTSNLVSFNLPGMKCHTAWNITSANASSTTGPFHLLESVSGLALTAWPINPAGHDTTHGPLTLERVGANDTRQLFYLTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD12</accession>
    <name>A0A8H5GD12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD12"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5362658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="22556" checksum="0CF5B07B7C4EAFEF" modified="2022-01-19" version="1">MSSASQSNSQSQSQSQSGSQSGSQSSSSSAIPQTAPAGIISLTQPPQQSTSFFKLAPSETINFQWSFSGVLHTPTSLTIQAIGANGFTYPIGNAPGTATTINWVPYDYQQSNVATPLAQTTYTLAVFDERGISATMKPGWLSPNTQLKFALYTPQPYTALSSGWSCPECNSATSITRENPALVASFATLLVVFLSGFGLLRNFYAYQHQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDQ9</accession>
    <name>A0A8H5GDQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDQ9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5362910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="69220" checksum="8B551C3B03BDF6E1" modified="2022-01-19" version="1">MQVMRTQSLIKRTRMITLKAVLSILPSSFATAMPESESSLDVLIVGSGFSGIYNLYQLRKLGYSARIFDAASKSGGTWYWNCYPGARVDSEIPVYELSLPELWKDWTWTERFPGWKELRKYFAYVVDKLDVKKYISYDTRVVSAHWDSVSDRWTVTTDTGVVVHPRFLIFATGFASMPYSPAFKGLETFEGICHHTARWPEEDVDMKGKRVAVIGTGASGVQVIQEVGPVVKHLAVFQRTPNFAIAMQQRKVTVEEQKRRKEDGTYPAIFRRRLQTPSGFWQEALPKPFASATPEERFLHWQQTWAQGAFTFLVTNFYDYAINDDANKEVYAFWRNKVHARVTDSVKAELLAPQVQPHPFAAKRPSLEQTYYEVYNQPNVTLTDTSKYPIEEITPKGVRTADGVHHEVDVIVLATGFNITATITHIDIRGRKGKSLKEKWADGVYTNLGMAVSDFPNMFFTYGPQAPTAFSNGPTCIEIQTNFIVKCIKYMIDNNLTFIEPLPAAEEIWREQIWETNKAGPWLKAKGWYNDLNIPGKSIQPLNYAGGVGKYAKICEEVGQKGYEGFTLVTRLPTGQTRIWVHDQGKVDSEAQAGRESESETQPETAIVAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH17</accession>
    <name>A0A8H5GH17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peroxidase</fullName>
            <ecNumber evidence="18">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_005559</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="18"/>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH17"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="6 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034522511" description="Peroxidase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="20">
        <location>
            <begin position="125"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="36"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5364631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="373" mass="40096" checksum="5BEB6C8BD4691908" modified="2022-01-19" version="1">MRFISLLSILHGAAFIAAIPTTPTRRDDGNDTNPKCDVYKDVLSTIQTTVFENVCGDEALDVLRIAFHDAIGFSPALNKSGQWGGGGADGSIMKFSDEELLIDQNVGLDTSIIRLKAIALQFVDISYGDFIYYAAAVATRMCSGPRMKFWHGRPAPIAASPPGLIPDPSDSVTKILDRMADAGFTPEELIDLLASHSLAVQEDVDLTIPFTPLDSTPTVLDTQFYVETLLEGTMWPGNGSNPGEAMSPFPDEFRLQSDHLLARDDRTACYWQSFIEDESVLGPRFAKAMEKMSLVGQDVDSLIDCSHMVPDSVAAASVRGPHLPAGKSLADIEASCKDRPFPTISADSGPQTSIPKPPRGNDGDDGDGAADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHN3</accession>
    <name>A0A8H5GHN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHN3"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="460"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="529"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="566"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="678"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="829" mass="90226" checksum="E4A5B69BF81A2709" modified="2022-01-19" version="1">MSDTALCTFDDLHPRQSGGGTASSIWAPQPQPSETTWPKTLDSFSKVAERDGQQVPVRPELQHYSSMPGPVVTREDVFGPTPPANDARASKEVGAIGDGRKRVTPDSFDSTHVEQLLRTLDLNSPDPYHLKQKPSLNLSFESSNGSPDFSPLSISSALLTPTDLSPTRSSSDLNAKSQLQSPYELISTRAPGYATHPSFLFEIDSPTRLSHSPPYGSSQQANTAAPTLAFSTGSFEQPATNPGYGGFKTFTEQPSPTSNAPMLPPPVSYPVYHSPTGSVYSYPLFNTSPARRSDPTSVIATAYGRASASNGTALGGAGSSDWHIPPQALSQSLLQQQQLQLQRQLQMNAASSEWVRPDELTKSISMGQNILPTSSSMSTGAIDLGLGLGLGPGLEESIHAPPSLGPAIGTTATITGYTNPQQFDLYAQQQQNGQHRHQLSQSQNQQQQQHQRNSSTSAHTQTPTSSPGQSSPGGHEPINFLSLLHPSSSPPYHSFVSRIIKSSDQQASIFLQQKLKVADTNERAKIVDAICARGFDMMAHRFGNWAVQRCLEAASSAEERKKIISCMRGRVVELATNCYGCHVLQKALDCEEDIRLLIVSELLLGDPAQTLVNKHASHVWSKIMELSWTPPAPPIFSFVNKSLKGKWAALACHETGSLVVQHAFENLEDSAKDGIIDEILNQGPSVFSEVTKNQWGSYCIQHILEHGSEKHRQMTLEHLITGLLEYATNEQGYKSITKALKEGGKDMLDKVIKRMCEPAKASSRRAMIVDLALSVTGSQLIASVLPTADKDQRALLYECIRGHIVTLRGCKTGSKVIWLFDRMRAYYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLQ7</accession>
    <name>A0A8H5GLQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLQ7"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="15"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="207" mass="23112" checksum="8CFC793D7EFF0E58" modified="2022-01-19" version="1">MSQTAAAIALSGQPTQEELNSPFIVSADKFPPNLPWPNISELARWSVSSFKFGFGPECLQDGDPDTFWHSDGPQPHFITIEFPRKVAVQKLSIYLSHPQDDSYTPSTLAIRAGTGPSDLQDVRIITLDKPDGWLTFDVSSEPNEDGEGLKPIWAYVLQVFIVANHMSGKDTHVRGLRVLGPIDLDQGNEEDPFAWSTPQFMMYEHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN05</accession>
    <name>A0A8H5GN05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN05"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="181"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="35595" checksum="458FEF885152F334" modified="2022-01-19" version="1">MSVHGVYDLLGSLLIAAWLSLMLYVLVIHQTNHYFRCYPADKGIVKAAVSGVVVCDTLATVAACGSCYLLLVKDKFYLSAYLTGKSMTFREFNSLRLPTLFRPTPLSLIVNGISAAIVQCFMLNRYWVLTSRKSVIGAIGLTILLHVGSVAYVTALIIAFYNDPSRTRILTGVILWLTSGAVVDVSIAILLVVYYMSTDVELRSSRRLIRRLTTLALKTGLFTAVTAILSLAIFVSDYQTNVDLIFIYNISHVYSLTLLYNLNIRRKLIGIGQTINLGSEVVMPNFRSGVDTRGRSSTSEARAASEHTENRKITGKVFATRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPG7</accession>
    <name>A0A8H5GPG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_003034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPG7"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="298"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="768"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="834"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="846"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5368824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111085" checksum="B7C243442EC74087" modified="2022-01-19" version="1">MSSILSDSRRQSALSESDTDPLSSSAASFKTAQTVSRSSSQQTLPPMNSVHPIYKPLPTPEPLQLDTSDSRIKNVIPPALPSPPASDDGEDETYMERERELELERLQKEKEKESLSRPSQSEPINTGRISPPNTTQRPSVETIRADGASKPSPTDYLQPPPMSSHAPHHRPHRRNTTGSTSRAGAVSSAAAAGPGAGRSLHTQYASQPHSHNSTSLVLDKSELTADPEPQVDGTMTDDDIQTSIQMHADRIRRERMEKRAHQQAQAEAQLTRKASSYTVGGKKPKLGEDAPLVGNLIGEDHVNYVLMYNMLTGIRIGVSRCQAKPKRPLTPEDFTAAHKYSFDIIGNELTPSAKYDFKFKDYAPWVFRALREDQFHLDPADYLLSLTSKYILSELGSPGKSGSFFYFSRDYRFIIKTIHHREHKFLLQVLQRYYEHVRSNPHTLLSRFYGLHRVKLPHGRKIHFVIMNNLFPPHRDVHATYDLKGSTVGREWIDKRKAQEEKERRESQTQSQVGRESQTSEKHRESENQREKEKDKKKNPTTPVLKDLNWIKTHQSLELGPEKRALLTEQLRRDKEMLKEIRVMDYSLLVGIHNMKRGNRDQVRRKTLRVFEPELKRELGKTEFGGGKPEFTKAGGIRELGAGDRASRSIGPGIIGASSSLGPSTSGGVGGRAPLTKSMSMNVNAARSSGSTSQDVLALRRAMRESDPKPFSEKEVFTRARSHGRSLSTASASSAAASMATTMNANANAGAGSQQVLPTVKIEAALGSTSDNNHIQDPQVGSGFGEGSRRSGEFCASPVDVHPSSASEPNPSQVHAQLNTNRTANTTETVDYFSHSSDATSHEKQQSGSNGSAAAPPQPQPQSQLTDPSNSSTSPTSNLTNNTNPQDSASATSATSPDQDGSPLPELDLPITMDEDNRAHFLFYQDEGGLRATDEQNRDMEIIYYLGVIDILTPYNGLKKVEHFWKGLSADRHKISPVPPTEYAERFFKFMKAIMRGGSGGEDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRA6</accession>
    <name>A0A8H5GRA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRA6"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17498" checksum="D196537E985A2798" modified="2022-01-19" version="1">MPGVRDVSADAFIAAYASHLKRSGKLEVPTWADIVKTGAYKELAPYDPDWYYVRAAAVARHIYLRKDVGIGALTKLHGGRNRRGNRPSHHANASAAVQRKICQSLEKIGVLEQTDNGGRRISQDGQRDLDRIATAVVEAAKEEEDEEEEEEIEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSE2</accession>
    <name>A0A8H5GSE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSE2"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="21959" checksum="0EA9DBCAB03CCE99" modified="2022-01-19" version="1">MPSVLFAYTSVDKSLKGGWYLPEAAHPYYVLKDFASIDFAALKGPNPPIGQGQVGKRQKGFHVYLPRWRSVIDLAEDPVNIKLVSEASKITAAERTLSSHRLHPYHYVVMIYRELVNAIDKDGLLEKRSLSPLPGQSCISLEDKIKALGIYKKASELLGEYVVIDGHLLTGQNPSSAGPIGKAIKEALGKELNISPCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSY0</accession>
    <name>A0A8H5GSY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_001859</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSY0"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5370638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="294" mass="33009" checksum="DA0E0A4930FA8C39" modified="2022-01-19" version="1">MAKSKEAKEIVAPPVPAKASTKKSTPTAVKYYLFAYNALSTIGWAYILILTLVHVFNVDGKSSSVPTAATTASSTLSRLFSSVPFLRSNQKIASFSGFESRLPSLLVPFFRRSATTFGRVGAVTAIIQSFALLEVVHVLLGWVRSPLQTTVMQVSSRLFLVWGIVEQFESTRRNPLYTSMVFAWSFTEVIRYSFYASNLLGYEPQILLYLRYTTFYVLYPLGAGSEAFLIYSSLPSSSPVPSWSSWITGMWKPTDYARAVLFLIWWPGLYVMYTHMIKQRRKIFGPKSKGSKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT33</accession>
    <name>A0A8H5GT33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_001837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT33"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5370558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="17738" checksum="9F0BDC14BAE0FE4B" modified="2022-01-19" version="1">MASPRILVQILVTGTRILGKAFLEAGRQAVKNASTPAQGAVGSDVAGVRNATSGSITDKLTREHRMTLDEAHLILNAKRGEEMEKILSNYEHLFKANSPPPAPPKGTPTSGRGAKATPAHSHYLQSKVVRARERIEAELKVASETEQAAETDSASTPPPPPPPPPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTN6</accession>
    <name>A0A8H5GTN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1863" mass="199798" checksum="EA80A1C663DEF497" modified="2022-01-19" version="1">MILSEQCSSTLIQATTNSDVASCLSLGTLLPLATGSSNTSVVDPINNWLNSVCSAPVCTNETIAAFVNNVTAGCSSDLAALGVSSSDASSIIPTIQSAYPAVRQVACLQDGNTKCITQTLNNIQDMVGPLSPSNVMNIGASLGSSDIPSNVTCTNCIKEAYNIINQDFPGLLSDAQSDLQSQCGASFTDGQTPSGISQSSTDAQNDNNGAIQAGVAPAQVPQFVKLIDTLRIFAANARQAIKESVKDMIGSRICHRRSQNYGILLPSLLISWETEMSTHMLVHMRSVIFIAVATGAGLVSVNGQISLSSSCQTALRGLITNEDAACLNPSALLNFAVQGGGSVPDAVDAWLNGMCSQGSCTDESISNIITGVASGCSAELATFGLDASDISDNVVNIVQQVYPTVRQAMCLKDDNSEQLCLTELLTSVESVIGGLSLNDLSFLNLMGDVQQLLSSGLQNLACSNCVKAGFSVAAENFPSILSVAQPEVEALCGADFINGSTPASITETANPEVFAAQPPPTNGGIEEMTGPRMPEEGLAEWASRIKALQRQVDADEEAEHKRLEEEIAASRMARMRRSRGGGNGSRANSVDLGLNKESLASLKENDDNSSRDNPKPSSERQRDQSDALEKLVGRSNVTGVPMSRPNTKSTPSFPSPSNPSEPVSLAAFMGGRATGPRLNKHAPQQDAHDPTQFEQRSVRSITAPHPVFGRGGVAMPGMAGAADRSSVRSPDNGTSHGGASLSASTNAANGVRFNDERSASPQKSDVRERTHSNPTKPNVKPIATTSVPSKSYSPSSVHKDEELARIRDRTISTPSPSHDFRPPMSPPAFRNSVASRYTDALRERPVSPKKMGSRERTLSTPGVLKGSFSAPNHVDNEGDISRRPRTPSRSRATEEEDAMPTPNSPPQHSPVTTPSLAGPIRPQPRTSLGPQISTSPAPSPAFLKPPAQKEPTPSLSRLKGRGFVQNMVKASMEIESSSASSSLTSTPEKSGSGSRKVLERWQNQGSQSPPPISPPVSPKPNPLRKSRTIDSPTPATSSKPVKPDLLPKSQVPKPSVSFASTTETIPPESRKPEPKPKPKGLKPSVSFSNLPPSEGDRSKPPSVTNTGLGSATTLVVFKPEGDVAPFVGVSELGVKRDSTSLSARNIPVSSGKPLIHPTKERARKPKKQGSGLKHEGSSAPSTPPDISSERVIHAEAAERPQMEEVTSNVANGNGGRVLDRWANQPIIGVKPISSREQSFEADKPRVAGMIGRRALPGLATSAAGPDVATPTRPPAIPRTTSQEAALTTPFPSSESKQDQIAVEHRGPVPPRSRIPSTGNRPTVMDVVETMKAQSVSPEPQASVEERPRSPAAVVVPEQMPQPVPELASPLRAPALEKRKSSYERYSAIALPPLHEERTPESTPANTLARNALVSGSIIRDFPLPSQAETDTVKPAKEPSRLTHILNLGLAFVDEPLPQVDPDILTQSHLSAKRKDLDLNTISVEVMSITGNSSTAISNPSHIFYDSELLSIIHRAKSKTNGLVTTDVWVWYGRNCLTGENEEKKLEDLAKRYRTSPVIVRQYHEPPELLRILGDKLAIRQVRGVRVHWSADNTGMHVIRSKKDVIYIDEVDLTAKNLCSGFSYCLTILETVYVWYGIGSIAAERKAALQYGQSLSSNVVEMTEGENDGDEMFWIVLGDDEHARAHYWKWRPVAADTETKIWRVNTLAKDVVMPASSINPDEIAGAVHILDCVWELFVLVGRKVRGNRNDIRLALSVATQYSTTVSPARPFKPPVHVIVLPSQLPQDLKLHFRELNEDALVRPSSPKEGKRSHLFPQNANDVPDHMNLMPVEEASNHLRRKQWDAFALRDPSFLPVGLDPSQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTY0</accession>
    <name>A0A8H5GTY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_004122</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTY0"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034776885" description="Chitin deacetylase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="47"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="483"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="555"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5371163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="66352" checksum="3E83364AFB312A1D" modified="2022-01-19" version="1">MIALSALLLASALSVTAHSHSDIHARVHPHSDIHARAVITPITECRKGFSMTFDDGPSVYTTNVSTNLYNANAKGTFYMNGKNWNCIYDPDIVAHVQHVYSHGHEIASHTWSHPNVSTLTNAQIDVEIMRLDQAFIRILGIKPNIFRPPFGAILSAQVDYITSKHKKLVVTWDSDSGDSQGVNTNAGILAFYKHLADEAKNSGTGTCSKEAVAILQDASFNLITTSECLGVDAYTYIGAPQTRDSTWTCDGSWDVSDYSETPTTSTATTTGKTASTTTSPGSTSTSVPTTCSKTPYTILNGDYCWKMQPGATLKLCPSSSTGSTSSASTSSISATTSQATTAATTTSRTSTTASITTSTTLSTTASSAPTSSTCSKGTWTVKSGDYCYKIATDNGLTVEQLQSYNSGLNCDTLQPGVVLKLCSSGSTGSTASTFTSSISATTSRTTTATTTTSRTSTTASTATSITLSTTASATSTSSTCSKGTWTVKSGDYCYKIATDNGLTIEQLQSYNPNVNCNNLQVGVSMRLCLATSGGSGTTTASVPSSSTVPLSTCKRTVKLSSQATCQTIANQYKITLGDFNAWNPTITNCGTLGTGKVNSGTPSPIQTSKTLNPNAIVQLLNGDGGRGLRLELGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU21</accession>
    <name>A0A8H5GU21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_004111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU21"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14309">
        <property type="entry name" value="UBA_scDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5371209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="419" mass="45514" checksum="C4E8CC1DE30CAAC6" modified="2022-01-19" version="1">MEITFVNDFGQTFVVEIDASMELENVMALLEAESGIPPAEQSITYEGRDLSNPKATMHELGVANHAMLTLRRKVVNPAGAPIEQDSEMMRLQLLGDPNLMRQLRETQPEIADAAQHNPQRFAQLLRQHHERLEGQREIERLNADPYDIEAQRRIEEAIRQQAVMENMEHALEYSPESFGKVAMLYVDVEVNGHPIKAFVDSGAQQTIMSPECAESCNIMRLLDTRFSGIARGVGTAKIFGRVHSCQLKVSDLFLPCSIMVMEGRDVDLLLGLDMLKAHQACIDLEKNVLRIQGREVRFLAEHELPAKARFEHLLNPDNPPSVSGAGPSGSGSSGVQGQGAGQGQSRQGTTPTPSSFPGSGTALGSAPAAHPPRNAGSNSGGFPEEHIKILMDLGAPRELAISTLAAADGNVDMAASLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUT8</accession>
    <name>A0A8H5GUT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUT8"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5371671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="81" mass="9345" checksum="F9031986DB165C28" modified="2022-01-19" version="1">MAQDFKDPPCQAQACDLQACLNKNTYKPEKCDQHLRNLYLCCQRMYQESSDGKVESTACPIPNVVERWLKDHGQLEPQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW50</accession>
    <name>A0A8H5GW50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_005051</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW50"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034149226" description="Cytochrome P450" evidence="15">
        <location>
            <begin position="27"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5372074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59550" checksum="96F7FD6F591372C4" modified="2022-01-19" version="1">MTSMTSIVSVFLCILTLYLFRSRRKGSLCYPPGPWGIPLLGNALQLLNVKPWHTLAEWKRIHGPIVYLNMAGQPMVILNTKKTVEDLLVKRTTNYSGRPHFIIPNAMTGGHHVVLMSGGERFRKMRRASDLALGLKNTVNYHPIQRNEAVFSAHSLLSDPDNWRSHVERTSSSIALSLMYDLPLIQSFQDPSIQRMNGFNDKMSASLLPGAHAVVEMLPSLLRLPRSFSKWRRDTEEFFEEWNAYFERAFMNIKKQAENGQEQRPSFSLALAENQANSTLSDRECSWLAGALYGAAHETTATSMMWFIFSMVLFPHIQTRAQKELDKVVGRSRLPSFADLKHLPYVHAVVKEVLRWRTPLPMGIPHLNSEDDYYDGYYIPKGTICIPNTWSLNHDPDVYGPDAEEFRPERHLDENGQLKDGLLGLSEGHSTYGFGQRICVGRHVANNSLFIIIATILWTMRLEGVKDSDGNVVLPDVNAEEESGILSRPPLFAIRATPRFQDADTFIREARDEVVEENLARLATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWV7</accession>
    <name>A0A8H5GWV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWV7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10626" checksum="476403C842773394" modified="2022-01-19" version="1">MPSLFFWMEARECEYWLWAMVKKGHKRVVDTTKQARALGMRMRGWLCCVNGVNYLKPYGMRPERISSIGSRCSAVTGSLHGHIVSWVFVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXA8</accession>
    <name>A0A8H5GXA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXA8"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF52">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5372991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40460" checksum="21D4EEB7BB559706" modified="2022-01-19" version="1">MTTTVIARDEEVSQSSSLQAAIARTATRSIALYFSRPVRLFRPSKLSGWQALRGLANGSTLSASNLSALVKQQGLYVLVSKHFIPPMLVNTTLGTVLWTTYQETFNVIEPHWGHHPILSSAFSGCVAGGAQAVVAAPAENVRLLLEGGSVYHGWSHAWKEVFRGTSKRPGSSRKEDIQEIRQLRLWMKDVGEMAGRGWDGVGFGIAKDMCGFAAFFALFEISRRAAVDTAEYASKTTRQLFPDQDSKSIQHTSRIVHGVSLVCGGVMAGLAYEIIGRPFDNARRIVHLEKVTHKGSSTSAPLAIWQHFRDEPIALFKNPAPAADTVEQMTSLGRRRLLTVLRTLGRVGPWGIGFLAWEAFGSGLHQGMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H000</accession>
    <name>A0A8H5H000_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H000"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="291"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="792" mass="89187" checksum="69C884686349DB61" modified="2022-01-19" version="1">MEPKLDRHDQSRVAHSAEAEIDTKEKTMIDAAQEKLGETTLEESVAHSPEDEPDVQPVVTDQLAKRIVLANLFAEKMKGEGGLISAENPNDSFEEMDEQLLTHLVGRIGKYSPGPEQQKALCSRCRRLTPQLVSEVKHEQCSFQHHSTYDALEESARNGCELCSMFVFAISRRPERYVWKRSDSVTISSTKFGYQTVDLAHLPAGRIRGKLMPAGWDDDAIPRHTDFLDKEAAAIKYWLRICPKGHTNCHAVQLNNGYLPTRVVEVGTLGSPTVHLVHMEDIDSDSADKRYIALGHCWGLNMPSSATTKLDTLDDRLSSIDMNDLTKTFRDSVEITRRLGVPYIWIDSLCIVQDSKEDREKETAQMAKVFMHAYLTIAASGSSDGTGGCRLLDKERPAGPVDLEFKEEGAKGGKMKIRLYSYPSQPLTNILLNDPLHQRGWALQERELSSRIVHYSHDSLRWECRSLKASFEFPWEDTLSFNKAVRIFDDGQLYPSPIEPPSSSTEEQRSTDLNASPPIFPARKRRLNENRHVWFDAVGRYTKRSLTFQTDILPAMSGIAHRIHEVTGDTYYAGLWQSFMPYGLLWTSKWDEEPYRSSGKPHERHPTYLAPSWSWASVACPVSYEWFIHDEFCLNPSPDPALIPTVLEINVAPSGADPFGAVRSGFIRLRGKVKPAAAKDLELFSPDAQIPPSRLGVPPSQRILPPPENGDFLGFTKIGVCHYDYPSDAPQEKSDMIFILCCLPGKEEDGDAVGLVLYPTNLFKFEFRRIGLASMVPMTWWDNVLDSDITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0J1</accession>
    <name>A0A8H5H0J1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0J1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="147" mass="16052" checksum="58E590441B9F794E" modified="2022-01-19" version="1">MDLLPDMMNQIAKNIIIIPQVANTSYTNYAIMIMNQVVGMYPTIIIVLVALHKSHTDHSFTYITESGPDRVSGFMSGKPSTYSTALDPMSSSIQDGTILVITERRMDTDSTDLTRNGMNSCSNFSGSSIDDVCGDKEIGRVTGMEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1M9</accession>
    <name>A0A8H5H1M9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1M9"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034168738" evidence="1">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="33768" checksum="AE83349610EEDE1B" modified="2022-01-19" version="1">MTFSTVNLSTTLFLITVVLVCLPAETYAFGAGDIPDFSYLQDKAFRHGDIENILSECLKSAGGAAVSGGLLGFAKKMVDNAKGGSKFSKSDVKKVYFGNWLRDYSQAMDIAGLSKLSADTLVLIVSVLGFMSFGFATEEFEVTADRLGVYLPVEHIDNPKGYAEKEGDARQFHPKLRPPVDPRELEIDPRTGMKNYMATEDQGWDSSTAHIRRVFRAAIEHGRRSGGEEGPDLWEAYRLLGTGLHTMEDLLAHSNWCEIALHKMGYSQVFCHVGDDVEIDTPNGRAPPLVTGSFGGADFYALGFYALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LNR9</accession>
    <name>A0A8H5LNR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LNR9"/>
    <dbReference type="OrthoDB" id="3062963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="24044" checksum="D2950499E91727B6" modified="2022-01-19" version="1">MTTAYSSFFASGLLAPPQNSYDFRNILPTIPSSPTPGMMVDVLDDTSDVEIDRMDRERSTTPTPSSSGPNAAGNGQPRLRKRRSSLTMGTSVLNGIKSPMRNAGNAFQFQRHLHSTPSRSRSGSLSSVITYEEEILPAPAPVTADPNKRKNRLRSGSIGTALKARSIPRAMPPPEAPLPPLPPLPSTPTHMKSFSIPPRFSMPVIPAMPMSSSSRQVLGELQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPG4</accession>
    <name>A0A8H5LPG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPG4"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="147"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5364644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="35146" checksum="B77E7A8BBE916BAA" modified="2022-01-19" version="1">MNTAGLRHHCASASKSLCSRSSAWSLQTRSVSSSPYGRTHVWKRREPTLPNPLPPKFPQRVIRADGSSFTHWTTSPRSILRLTRDTTNHPVWNTYMWADDEAVEDEANTTGRVGRFNKKFEGIGGHGEQIDFGEAVKETMDNTTGGKLEGELVDPSKYVQKKKKKDRRRTTPSYIIGQDGHENILRTTLENEYGCKVELGTEFIAFEQYPDYVVVHLQKTVDGEKVSETATFSFLASADGARSQVRKQLGLSFLRQTITSPGMLVGDLDIKGLDRKACIVTTVFSSPLLLLHWLQKPLFWFLVSDQLWMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS28</accession>
    <name>A0A8H5LS28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta(14)-sterol reductase ERG24</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_003616</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS28"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5367418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="433" mass="48845" checksum="C59B026C732665BF" modified="2022-01-19" version="1">MTSTSINPRSTSYEFLGPPGALFISLAVPITTYALYFGCSEEAGGCPPPDLQTIPDRVTLALSSPQWWKSLWDTEAALMYLGWYAFCVVAWAILPGAVIEGKPLRNGQTKKYKINAFSTFLLSLGLATGYIYRFGPESFTFLYEKWVGFVTASVLMSFVQAVFVYAMSFQDGKLLALGGNSGNFIYDWFIGRELNPSIGSFDIKSFNELRPGLILWALVDISMACEQAVRRGGFANVTDSIWLVLLFQIGYVADGLYNEPAIFTTMDIITDGFGFMLSVGDLAWVPFVYSLQARYLVFNQVELGPVATALIVGLNGTGYWIFRDANGEKNDFRNGRNPKHLTFYTTKSGSKLLTSGWWGRSRHPNYFGDILMALAWSLPTGFNTPITYFYVTYFAVLLIHRQRRDDENCERKYGLDWERYKEIVPYRIIPKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTH8</accession>
    <name>A0A8H5LTH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTH8"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1010" mass="114381" checksum="14893C298A0DDA33" modified="2022-01-19" version="1">MGDQSDAGVVQGKTSIDKGGLDSFSFLSNTEHVGRSNLADALAPHKTYEGRHRYDPKATWTAAEEKRIVRKTDFYLLTWICIMFFGLQLDRGNLSNALSDNLLEDLNITSDDYNNGTTIQLLGFLTSEFPVQLLTKRFGFKYVLPTMMMAWGTVSWAQAWMTSRTSFYVTRALIGVCEGGFIPGAILFATYFYTSKELSVRLAAFWSTLNIARVVSALLAAAILEMRGVLGKSGWFWLFLIEGILTCLIAFVSFLYLPHSPTKTEGIIWRKPWYTEREEVIMVNRILRDDPAKGLTALREPATWQDIQEAWKDPSMFGLYFIGLIAYIPASPVQAYLTLTLKRIGFSTFDSNLLTIPSAALQIITMLLLAYSSEYFNERAFHCFFGEFWIMPILIALVSLPDGGREWGRFSIITLVVGYPYFHPIVSAWISENSFDVKKRAITAATYNVIVQIGSLIGSQIYRKYDAPYYKQGNAVCLAISVLSLLTFPVQRQVLVYLNKRKEKKWNAMSAEEKVTYQNDQEARERDGNKRYTVLRLDSIKLGTLRSLGVMSYAEEQTIIPNPAIVATRVIKEVCDEFFEWEKHECQAVIKGLSKDALSPGAYRPVLESFSLGIDTIPGTVTRLESTDEGDYLEVSAYRDYEVYTSTVIPGVVVVERQQPSQRYYSCTPSLRSVRDLEIGKMEEIDFIPHADDPEFPIRKYLGLIRGTDSEPPAKRGTVWESEEFRDPDGEAVEMEAIRRLLYRQHLSLQQIDETQVFKRPMRARHDWGLLWIYSQRDPLVWPGAQNSNLPVLDLAIAAPAHKWKDVISYGFSRFCGNLNCVVQSCQVHEHDYSGLPVTKAKVHSTAILAEAENCGTDCVFRREYFESGGGFNDDHQPWDHEDVDLLKLILEITPDEKSCKLAVLCRKPCWEVWPHFLVSLCLWLTAMSRHLSTGPFYYQMKTLKMTLKLHQQSMMRQTSRKERALLSSLVLTRDLAVETPLAGVSSLEGFAAVAVGVLKSAAYVGRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTY8</accession>
    <name>A0A8H5LTY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_002802</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTY8"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5369457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="699" mass="76577" checksum="FFE7975F5A0126FE" modified="2022-01-19" version="1">MSSTAPPNNNPPSDNNEKQPESSQPSSTSNAQQDAEMDTTPDQPAEETWDDIPADIMSLSTDEILTRIRLIDNDIKVMRSETLRLQHEQSVMKEKIRDNGEKIKQNKVLPYLVGNVVEILDVDPEGEEDGANQDLDSMRKGKCAVIKTSTRQTVFLPLIGLVPPEQLKPGDLVGVNKDSYLVLDTLPTEFDSRVKAMEVDERPTETYTDIGGLEKQIEELVEAIVLPMEEAEKFKTLGITPPKGCLMYGPPGTGKTLLARACAAQTKACYLKLAGPSLVQMFIGDGAKLVRDAFALAKEKAPAIIFIDELDAIGTKRFDSDKSGDREVQRTMLELLNQLDGFSSDERIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNEKARARIIEIHSRKMTLGDDVNFEELARSTDEFNAAQLKAVCVEAGMIALREGASKLGHEHFLSGIAEVQRKSDPRFTRLKDYQTPIDAFLNALLMLVAGCEISSGYKRSRLRCTVVEFDTGTLRKSQPSSLEVFIKTTQLAFAYPPMYNPSKVLCLLLPIFALVFAAPSRRQSTSGQIISPAEGTVISPGQAFDFQYDARGDYGVTSYNYTVFLLTSAPGSFVPSEEFATGHFFGRFANANYPGNPNPSNPPPAQLVMPDFSKNPGGFGTGAVDSNGKFYLAVLEEYATGSASVGLRISLAMTPVMYNATTRAIGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTZ8</accession>
    <name>A0A8H5LTZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_002644</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTZ8"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="236"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="436"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5369488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66073" checksum="AE3075276B0532DC" modified="2022-01-19" version="1">MSELDVQSLQAEVNRLKLEVNALKVEDRSEQVYIGNYLLARLEQLGVKSMFGVPGDFNLGFLDLVEDHPTIDWIGNCNELNAAYAADGYARVKEQGLGVVLTTFGVGELSAINGIAGAFSEMVPVLHIAGVPSTAQQKLKPMLHHTLGDGRYDAYRKASEQFTISHAELQNSSTAAVEIDRVLTDCILHARPTYMTLPTDLVYTKISSERLKIPLSHLPPPNEPDEEEFVLSEIEKLVEEADNDVIVLVDACAIRHDVRKEVKELIQKTQFPVYSAPMGKTAVDETYERYGGIYVGSISHPEIKEKVESAKLILSIGSLKSDFNSGNFTYSIPTTRTVELHSSWTKIRYAGFPGIGMKQLLPKLTKRLHEVNAAARQIEVPKFVATVPEESDDVISHNWFWPRLSCFFKPKDVIVAETGTSSFGILDVPLPKDAVFLAQILWGSIGWTVGSTLGAALAARELGLGRTILFIGDGSLQLTVQELTSMLKKDLKPIIFLLNNSGYTIERYLHGKHRHYNDIVNWKWTSLLNVLGDVDGTKSKSYTVNNKKELSELLDNASFANAEVMQLVEVMMPMHDAPRALQVQAELSGKTNKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUS4</accession>
    <name>A0A8H5LUS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUS4"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="783" mass="82786" checksum="D7FC90C14DF4B0DD" modified="2022-01-19" version="1">MLRSSSEWFLDEKSGQQRKLYEYCSADVRDIVKRHVRYNGEKDSKGPGDFNGSGPSKMDDIGEGDEDDDEEEIVQKPTKSSKRKLALGDKMDADNNSSHTNGAKKSSRSNIDRDLDDADFDPDFDQAGNGTSLPVSSDRDREYRSSSHHGPGSSLNLDLGADLSPDFSGPGGLAGYPGDFRPHSRSHNPRKRSLSPSMDDYPGAGSRGRSASSAYPYPSYGHGYADRDRERERYSIGVGGTGLSMGRRHSMYPGPGMGFGSMGPGSAPFGGPSPGGFGGGNNSPHPFALPSNMGGPGPGPTPVSGILGRGSDPFANPMAEKYAQMHTNIPTPPSPALSSGGGGGGVTTATTTAPHSFDGLGGSGMGGSLPLLGSNEANGIMDPRFIYQQAQLILQQQRERERERERERDRLRLGMKDWDLEREREHSRGRALSRGEDRDRGSRERGRDRDSRERDEEWEKMKALAQSRDMERRRQLSISQMVRFGAGAGYGHGAGLGGIPNIHTGSGSGSGPGSQFAQLQQLQAQYQQSLATAGQAQGSGQGQSQSQSLTDLFAFLDAVDNPSGAMAASGQSSGGPGLDFGLDWPAHGPTQQQQAPASANPNAGGGGPGSESWLDFLSGVSGGSGGPNNGMAGPGGDMSLLFSGGPRVPGSSSSVLVSDMDLAGFDLPDDQDIKPVTKKQKRVKRDRDEDDIDDYGGGESDGGNSGSEYAPSPGRGSKNAKPGNGKTKPKGKAKEKEKDRGRQREKARNKDRDTDGAYGEDMVMDVDKDKNNPKGSGSGRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUT5</accession>
    <name>A0A8H5LUT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUT5"/>
    <dbReference type="OrthoDB" id="2654453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138358" checksum="1E77262DACE494C7" modified="2022-01-19" version="1">MTPFTFTTNSKTLKSKNGKYKLRALLAGHQGVVVCMTAHPLGSHVASRDKKLLGSPTGAGDQGVTTALAWMIRPDDTDDGLAFGTDDGYLCIWHHSRKEQEFTEVYCNHLEGGENGQEITAIAFDASSSQLAVIHRAEIVHRFVVNPLMRLTTVKSTRIKNHWPQAVGFGQTAAHGPKIWSFGREDGEIHILDEGGKITVTKTTGVVINVGFHDGGKALISRSDHGDVYIFDQRTGEVNDIIQVGCKDWVQSITEQTTEMEGVPIIIIGRSGENLGQTALQVWERETPVPEREGNLPPGAHEWMEIVTGLDLGIESIADRDIDTLSQTVTKSSYHLVSTPSSSRTGPHPLSPLKRTSPRRPSPSKEDQQTYRGHPIVTHPKTRSQTVTKSSYHLVSTPSSSRTGSISPRKDQSRSHKERSPTKRSKMGNSNNTPTDSDDYDDMRRISGSLQNLTIERPGTDVLAKRTPASGNTNETSSLSIFVANENQFRTYLASMEAADRTDSVPSFLNVPILAIQQVLDWENFLESQQICCNYNLLCIFKTIEDEGGQDLDKLFDMFPEKEKKEVAELTETFTESGWYQTRRDADKQLAHHAAVSKVFATHITVDLTLTHHVKPFIFHICCESLRMHHRSLFLALPSPSEKILRYYYLMVFSKLRCTWMTLADLRAQVEPAGDYPLRCDKIMDLACKQPGLLPLESLFRRPLDNVIEDIWTSHGLPVQLFAERLVRPVVNSSKDLRLSEYSRADQYVIISLSIGPTLTQEQLVYITTLLDWTTLKERIPEPFCGHNLDIPALFQEFHVAQFEVAKNQVCAGLLSGATVYACVNIPYLLYGLATSMHISALFVACAQFKDDGNLQFAIQRVQEWGPLVDPVNYFNYVSTLDAHAQWFNDHVWKHIQDSQNETSALDWVLENLKNRDIKRPWMKSDLPYQPADPVKVDHIKANHKQNEIALADSSDDPLASDRIVDWVHETSHQTSHHVVPDDSPSHNDNDNTFLTNDTFPNSKSSPNAEKDDTVASDSFPNSKSYGVELEDTVVASSSTVPIFLDPAVDGAVDGDTPNVKEEDESDNSPFPDSNNPIILKDSWSLICCTVVLLGIYSLYSFIRIRFGATISEDECVSSSGADRMCFYHHIGSSFLGNWKQGKLSWMICILNIRPPPIGKTIFVLLTDKPKQDALIDLVETPSKKRTISRKSKANPSPSKLKNLVRSDPGKNSVPLNGFHGLVRSTLRIFGRRRMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV94</accession>
    <name>A0A8H5LV94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV94"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="45831" checksum="7CE3F27759A84D43" modified="2022-01-19" version="1">MAVWSCIIAVDQYRSGEVWDLQSSVNDAREIKHWLVDHLKVPKQNVISLLNEQATLSRIEATLRSHLLNNDNIQKGDAILIYFAGHGSTVKTPDDWVEGETDTTARVEVLCSFDHETKTSEGRVAGISARAMQAFLHELSSKKGNNITLMVDTSFTPSQTRDRGRTRWTSSNKIAPEDLYSGPFSAQRSQVANESFYDYNSSHCFIAASKADSTAVESKEGGRFTASFLEAVLSAPLHNTSLRSLMNDIARRMGDQQPMFTENNRLLLGGVPFTEDENFVRVHPVDSSSLKLDAGSNYGIVKGGQVTLHVHNYSGSRNPAVANAVIQEVHPTYSILAVRSKSRYTLLPTSCWARIDQHRALASIVKSSCASVLQRLGFQKRTGSVPSTAHPSPPSRASTLDKLDISQRELVISALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV97</accession>
    <name>A0A8H5LV97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV97"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000084">
        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="180"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="66612" checksum="2966CB0FDE4FB29B" modified="2022-01-19" version="1">MATAFRSFQSEIEEIHHRELTKQRVQGAAELKERETKVPKGKPKEELRPPEPSQAEPDQQADSAEAEEKILKLLASKTPADHDVARDMIAGLITRHHGEYVLRIGAQPPHAKLFAGEVTDDSEGWVGVERTAEELDHFRQAITSTVDEVGGKTSLLFESKGKHTRLTLLLRLPPPNVSLTPEVRCAVVGNVDSGKSTTLGVLTRGALDDGRGRARVGLFRHKHEVETGRTSSVGMEILGFDPSGKPILPETANSTDPDVIRREKLGWEDISVQAAKIVSFIDLAGHEKYLKTTLYGLTSGAPSCVILIVGANAGLIGMSKEHLSIALALSVPIVVCITKIDMTPANVMAETVKQVVKILKSPGCRKVPVFVKSSETAIEVATSFGKDKLCPIFQVSNVTGEGLDHLRMFLNLLPSSEADTEKFAANQPLEFSVTEVWSVPYVGTVVNGIINGGRIKIGDPVMLGPDSNGNYLTTVIKDMQRKRASVTSAEAGQVVSCALKRVRRAAVRKGMVLVSKSESPPKAIRRFEGQVLILYHNTTLQRNYQAMLHCGAVRQTVRIVGMDHPQGVLRTGDRATVQFEFISQPEFVKEGMKLLFREGKTKGLGVITKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVI4</accession>
    <name>A0A8H5LVI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVI4"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="164"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="470" mass="53302" checksum="07312EAF6D471DE1" modified="2022-01-19" version="1">MAVKEKHFCLLSKQVFLLPWHPKPTETLPLITSSVPSLAPRPLPNSFKLQFTTQKDDNTSTHLYRTASGQQLPCKLNVPLTSAVYPNNMLLPPLTPSLINLGGQFSRSPMSFLVNLQRLYRHALKRSPIASYPMASLDVRPQRLIDIYTHQPVEFQKNDRIPPYAILSHTWTKTQSGVADEVTLSELRSVQNADKIRSKSGYQKILAACSQAFRDGLDYIWIDTCCIDRHTHEDVARNIRPMYAYYQNSEICYAYLADKQVGSEERWTPGDNMWFRRGWTLQELLAPREVVFYDAKWKQIGSKRFLQDVLYHSTAIPQAVLTGTQPLQEVDPIERMSWALGRETTRPQDQAYCLLGLLGVSMDPDYDEDVKSAFGRLWTAFVESFVDAQPEHVVAVGSSEDFYMFLHGKHWNARSEALEFLRRRLNRPKKEDGPAGGEESAHSSETGIPRSLYSWGWTDGEDGAGGADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVK7</accession>
    <name>A0A8H5LVK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVK7"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="3">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5371152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="450" mass="49542" checksum="3273ADD824C982EE" modified="2022-01-19" version="1">MTCIEQGFKTLSCVDESFVDVDNVSNCTESREVPRTHPKLVPTYLTHPTMTSGWSDGICWLGAPPEAHPPSKSEASLADRRQIIRSTRSPNLTSFTFTYINPVLTPGSPSRPLRCWDQTSYIRSTSALISTATLKTEKNSTTTVSNSLVPTLITPSPRSATTSGEGENSIILPSNPALLRSHFLRLAFSHLPFSGPEFSTSTVPSPDITHTPLPLSAPPSAIPTAHPSPTLAPNPSPLPVSPTPLSPDINMSSATLENLLQALVNNQKQLQQAITNLVNRPTHKSSDKTAKPAPFKGEPAKLDSFLSLFILWAGEQKWLKLDSGKLDPRKCIAEALLMMEEPAAEWAAEYARHISRVRAEEAGAVFPWEGNWDNFTHTLKVRFGVANEQQLAKNKLEVLKQGDKTVTEFSQIFKMWAEKTGFSDQDLQYKFRKRLHKDLFKCGARTEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVR2</accession>
    <name>A0A8H5LVR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004083</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVR2"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5371333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="14004" checksum="7D6DFED122CFCC17" modified="2022-01-19" version="1">MSKVVTAEELKAHSSKNDIWLLISGKVYNVTKFIDEHPGGDEVILAESGHDATEAFEDVGHSDEARALLPDMLVGNFEKSEASKLKSAAAAAQEARASAAIEQGSNMMYFVPLTLLGAYFAWRYYSGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVT3</accession>
    <name>A0A8H5LVT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVT3"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="316" mass="34395" checksum="274060D2E8AF56A4" modified="2022-01-19" version="1">MAEVPPINISLILGPVVVATLVNALLTGICMVQFLEYYDSRIKDGPSIIGLVIWVAIVDTFSSCTSSYVLWHYAVDNFENKIGLFSAPWQSTTIPITTTLISVPVQFFLARRIHIFSKSLVLFVIICALSLAQGGLAFASSIGALLDPYVEEYAKLIPVTDSWLAIAVACDASITMVLSYYLWKSRAGMKASDKALISKLIRTSVETALPVTVFCISGLVFLVNHHAQVKPVLDILIAPIPIVHKYPPDDSQQSFHHSSTNGAPALDYPDHWRTEFGESHTSIIRGLLGLIARPRLIMITPNGTTLSGSLSDSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWT4</accession>
    <name>A0A8H5LWT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWT4"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="3">
        <location>
            <begin position="362"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="69377" checksum="A08EDFDCF91859A5" modified="2022-01-19" version="1">MDQTNCQKTVKFFFYCHLGAPFQLLGFFSMASPQNSTETHRCSDCLKDKPLTAEFFNYWGGKLTKVCSDCLAKSKRKRASKKSKLNQDKAPTPETATGNSESMESDQGDQLDLEVDLEGVSEIPLEDFKKSIEGEDNIHSFAAQVNISGLQGANSKDLRTKGDQVAALVWEVTELRFLYHSKYEHKQSPLIRFKYHCAQQDKRQHKSSKTESATHRDKVQMHSFSCKGWLYVTVYDDEPYAEIQLKHGTDHSTYAGQDVPSDIRNILIILYVKLWTEILKKHPHPLFKRRAIYRIAANAKCQQWFRDQDELKSAKILLDECQNSANRYTIAEITLPNVDGYNALAFSLPDVLAKFGGRVREILLDSAWNTNGSHYELYALLGEVYGSGCPLGYLLLQSPKSGEEGVKQKYIQAFLEHFKEKYELNPSFTLTDKDLSEINAFLQGFPNAKHQLCFWHCFRAVKQRLSILRRQPKFYNVTEARNEFGDAIDKDFVPIGQVDDTDCVDFAVAQNAIPRVTVRLNGVLQGAVPPKPRFVIRINGGTRSLDPESPEPEPNVESSDSGKDEEDDYMGEDQEFSGDDDTDDEFGPDWMFDNVELAHSVAAINVIYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY29</accession>
    <name>A0A8H5LY29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_000878</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY29"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="287"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="455"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5373748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="613" mass="68507" checksum="3C75D7EA5F494EAF" modified="2022-01-19" version="1">MAHELEEGVCARLTAATPNDDTLFTTPHVLQVLSVKKIGKESGSSSTDRFRVILSDGQHFTQAMLATQLNHLVHDHTVDKHTIIRTDRMSCNFVQDKRLLILMSLSVVGQSEEKIGEPTAIGPAEESGSKPPSAVPTPAPQKPAQSSSNGSAYNPKPAAKNAKNSWFPIEALSPYQNNWTIKARCTQKSDWRTWSNNKGEGKLFNVTLMDETGEIRGTAFNAVADTLYPKFEEGKVYFVSKAKVQLAKKKFSNLPNDYELNFERNTEVEECTESTDLPMVKYNFVSLSDLENLAKDSTCDVVAIVTNVSEISTFTAKSTQKELKKRELTLVDKSGYATRFTLWGKQAESFHTDEPNPVVALKGVKVGDFQGKNLSMASSSIMNLNPDIQEAFALRGWYDASGRDQSFQSHTNTSGSFSGGGGGGFRREELKSLIDMKRDSDVLIKSPQDEVKPLFFSIRATIMHIKADNIAYPACKTPDCNKKVIQNGDVWTCDKCNKSHDGPSWRYIISMACSDPTAQVWLQGFNDVGEAIFERKADDLMHMKETDEGSYNSIMHHSICKTYNFLVRAKPDQYGDSNVRMRYGVMRVSKPDWKEESKFFLERLHSAWGQQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYA6</accession>
    <name>A0A8H5LYA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_000640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYA6"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000006">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="139"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="332"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5373836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="45386" checksum="EFBDD2B68062D7E0" modified="2022-01-19" version="1">MTITFHALPLPIVQLSLDAVLRCGQSFRWSIFPLAPPADASHEYRLGLRDRVVCLRQSPTHLYYRSVYPDPQPSETQSRLLDAETLLWLKDYFQLDVDLAGLYLEWGNRDKVFLGLKERFSGIRMLRQDPWENLISFICSSNNNISRITKMVNSLCTHYSPPLLHLADPSCPKTRVAYHAFPSPSDLAQPEVSSKLRSLGFGYRADFIQKTAQMLVESHGTAAEKWLMDLRNEPTEKAREELLKFMGVGRKVADCVLLMSLDKKEVIPVDTHVHQIAIKHYGLKGSVNGKKTAMTPKLYDEVNTKLVGVWGNYAGWAHSVLFTSDLKSFSSFGLPTPSPTPTSSPTKTPRKRSQKDLEDIESVLHTPPHTREHLTPNNSRIIPAEIDTGSLVDRVKRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ10</accession>
    <name>A0A8H5LZ10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ10"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="279" mass="31408" checksum="E3B2561ADFD6EF06" modified="2022-01-19" version="1">MNEEDQVVSSLPIHYSNRLPLQIHQFPLLSRPLQIPPSAAASGKRISARIKPGVRRLEVHVPADTRPDVWNSERGKEYGAGQREDDREKNQERKGKERAGEEPRLTDVRLRSEEIPIQGVQMLGIVRDGELHLHPVSQIHQFRPTLTYLDILSRKTKRRGADSDSDSDNGPPPDPDDPVPVAAPKKKEKKAAGPSREVHASAKKAVDDQTGNLAQLSTVRREMLAAIRTEEDESWEDLGYFDVTTLEAEEAFEKLFSQNSEELDCKSDITQFLKDIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6F9</accession>
    <name>A0A8H5B6F9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000486">
        <property type="protein sequence ID" value="KAF5317432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6F9"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16388" checksum="3000301BD0A221B5" modified="2022-01-19" version="1">MDDDHVKFLLPTHKSAKQIDGNKIIVQATDGEDCPVKITRQYLHLRDSLFPGHPNLFTRKDSAIPTRQWFIRRLRHYFPKDVAGHSLRSGGATHYALLGYSWDAVQTLGRWTSEAFRLYIRKHPLFFSALLTKKQTTPLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZB5</accession>
    <name>A0A8H5BZB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000311">
        <property type="protein sequence ID" value="KAF5332342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZB5"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="11893" checksum="1EE5E53A79F563B9" modified="2022-01-19" version="1">MVDTREIVSFYPWGHLIPQIFTNQLHTEEGGEGLDIRPSIAVTCAHIKLSKLDETVRRWEIDVDGKIVMKTRLVKREDGGMDGGVDPGMEVAVTKAAVEPVSYLTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZQ7</accession>
    <name>A0A8H5BZQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000312">
        <property type="protein sequence ID" value="KAF5332328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZQ7"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="38874" checksum="CFFC35C1EB76CFC5" modified="2022-01-19" version="1">MTRSARLQHHPKAAGESNSTQLNEQSTTTAPRSSKRAQDDETARVGERSKEVFSDEAEYSVFGGKRKRGHGGNSQKKRTKIVAADEKFRGKLGPLQKLVTEVPLDVVFETFSHLEPLDILRLSRTSLVLRNLLTTRSSGHVWRNARLNVAYLPPPPPDLNEIQYAHLCFDMLCSVCGLDCDHVCWDVYLRFCKSCVDNVYVWFAAAHLLDFRSLIQCDVWQMWHVRQQINRIRESKDKRRQVLKDIRRQRKEDIEARLTTLGWGPEMKRLKDRGEDILDAKSVKQPVKLTERAWQMISPGFVKILQAERAARLTEKERCQVLTTSDTQLFKSPTQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3L6</accession>
    <name>A0A8H5C3L6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000262">
        <property type="protein sequence ID" value="KAF5334338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3L6"/>
    <dbReference type="OrthoDB" id="3066951at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="326" mass="37053" checksum="79A9C18D69E5E26B" modified="2022-01-19" version="1">MDSWKRLVKQVVRTTTPRINIIDILDETRPGRPLPNLPPELWIMILRYACLPPEPRTRSAAGEDQSFLDTPSYYLPSSHPHYTPSSSLPPPSPLSRISSNTSNNNTSSNTDYPYPTSASLNPHRTSPAHHLYRTLMDQKRSFALVSKLWSAYSQPALYEWVWLSNKRQAKALALTILCQSVYTHYRLQVAGCGRPMTPLLRLRLQFSRLGPRCPSSPVRYLPVFRHPVTHPSIQRLLRSIFHLPSLVLFTVLFRSVPISVPFVLGPPSHFVFASFRIAVVVVVLDVGWVMSLLLILRGSRLNLAAAAYRILQTLYHVPSTMELWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3U3</accession>
    <name>A0A8H5C3U3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000252">
        <property type="protein sequence ID" value="KAF5334740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3U3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15514" checksum="2E8368A3509F78D5" modified="2022-01-19" version="1">MSCSASRAGFATGGYDGEDILQIDAGREAIVVGIEYRLGLFGFLAGSKLKEQGDLNVGLLMEEEVLDRVWHFALQWVREHISKFAGDPSRVVIGGESAGAGSILNHLTANDGQTSPPLFHGAMPNSMYLPLIYPYNDTMPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6I8</accession>
    <name>A0A8H5C6I8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6I8"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="43506" checksum="D93AA7CE9D83CADA" modified="2022-01-19" version="1">MSTALASPPVLSTAPAPGSTDPPGLQDIWNSEIDLAIMQFLYQAKTQCNGTCDTFSAAVWTSLGKHLMENGHRLCTNEDLKDRFRVLKQRGYLLSPTGVIVPAAPSPAAPAATVPDRAQWTSEAEAISIEFFIAKKAQGLMSENNFKGKVYNLAAERLCAKGHSFSGKQVKARWTRFKAEFKIVAKLRTLSGFGWDNARSMVIATDQVWDAYLVGHPKARPFRTHPFIHYDDIAAMVGHSTATGAMALSSENAVAAQKAPDTSSSSDDDDEDSDSDAADSEKESPVKKRRAAGPTPAPKRVRTSAGAQALTSMSSTFAALTEGLKSGEFLTSPSTDSPVKKKKAFDIVRAEEGLSPHSLAKAHRVFHGSGEVAREYLSFDSTKDEERSARTFWLMDEMDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C734</accession>
    <name>A0A8H5C734_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000233">
        <property type="protein sequence ID" value="KAF5335904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C734"/>
    <dbReference type="OrthoDB" id="2898134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="179" mass="19190" checksum="D89E99D0C147D03A" modified="2022-01-19" version="1">MSKHIPGTQSHYRAEVYAVLLALQLAPPDRALFLHLTSESLIHSLTYGAPGCVKCGWNGTGAHSDLFKCLALEITACSSPVKFIKLVSNSANNHQIKATTLAKAACQLPFVIMGDKSNDLSLTPPGPCFIPPPHSRIQPKISTNLPQPSSLLPTKHPPSSACSCCGHAFRHSLQTAMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBY2</accession>
    <name>A0A8H5CBY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000193">
        <property type="protein sequence ID" value="KAF5338673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBY2"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="194" mass="21298" checksum="C5A8420080581292" modified="2022-01-19" version="1">MKGPLILVSPQSQVTVRRSALNARTGFGGYGYGLEIFTHGILVLFPNPKLPDCGIQAEYLSHSLDPVYPGTEPVLLPSKTYKDTDTHYDIIMVPGGPTDPATVDAIDPSLFGFLKREAKYLLTICTGSWLLARTGLVNKKRATTNKSCFNIVTEDTKDKDRFHMLIGSSMMISTYGRLQVSLQVKISVLHCSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDB8</accession>
    <name>A0A8H5CDB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDB8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="257" mass="28676" checksum="78755B19CC5C6D84" modified="2022-01-19" version="1">MSSNLHPNPNSSSDDGFPKDSSDSSPPTSGERYRYRDTNNLGITSVNSVETFYADMNPNLDGRASTCWTSQAPVTTTAQEPNHPALHTYPPRSRYQDATLTSVNSSERFDAHINVNADEDSSGSDQNALYSYPPVPRFGQSWASQSSPDQSSYDTYVRSHLVPYFQDQITPSLSDIRDKVEGRVAAWRGSRILRRKGLITTLGAGDWRSVDGVDVDVETEYYDSEDEDFLVVSRARRPDTAPELDVPSRFWEDISSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE32</accession>
    <name>A0A8H5CE32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_012084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE32"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF6">
        <property type="entry name" value="MAP KINASE KINASE MKK1_SSP32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="160"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="807"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5338827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118083" checksum="8338C0B50FD86370" modified="2022-01-19" version="1">MFNSASPKTQVATRREFPPWKRRQKSEEVTIICCLDRPEVDCVVAVYADPAVKGPANRVGMIHAISPLPQSNFIKLPNYMSSAPLSCLYTSRDIENDWFWNNLHSLDGDLAPFLMELLQIRLESIAGDSKIRKRLLQGMKLLNKLHGALPPSIVVHDVTREGTHPITGGGFADIWKGRRNGQPVCLKVLRIFTSSSDRKKLFKDLSNEVLIWKQLHHRHILPLYGVNMELFQPSYCIVSPWMSNGDIGSYLDKSAATDSTFERKVKLITEIAEGLSYLHELDPPVIHGDIKGSNVLISEDFHCRLADFGLSAIETQTQSYNVTNSAQNRGSIRWLAPELMNPNSVHTTLGCSKTRDIYAFGCTVVEILTGKPPFPEYKMELHVMIQVLSGTRPPRPAECTDELWDLIERCWDESLSQRPGAGWILNILRNCSLDLGSWEEVVEVGSEGEAKIPASSLQLSSMNALFSIPSTQDPPREDQNWASPDSWACVPAAESVSPVKDATLASDSPQPVPKADVDEDYVLIRKRTVSTSISVKESGRARSIPIQTSEQNPGGAASADQSAMQTQKQKGTFNSCAPSHIPPPISPQTPTLTSLVSKHNIREGYATIASPSCPASAFSLLSNGGASLRGSILINPGLPSTSQSGSLINHGRVHDSLDGVVRRPRGPRGPSASSFTRRDSRIMPNPTWSKPTSPVPVQSSLTIPKSFDPRSLPALRPGSTTGKSSKKLGLIIPAPNHSNFESYAGPSGFTPMSSQAPEEICIRPAAAPSHANDSLSHIIEEFNTDLRLEEAKRKDGAFFSKEWNDDAFKEISLLSGAVHKVQEKKTDRIMACKMIALPIRQHEDELSTIHSANHPNIILMYGAYASPSPSSRPVKLLMEFCEGGSLEAIGKCPKEKGAVLEETVAGRIAEGVLQGLDYLHSMRMTHRDIKPSNILLTRQGVVKLCDIAVSGELIESFAGISTDTSLYMSPERISGHEYNICSDVWSAGISLLELVQQRFPFPNDVPPIETMMYITSQDPPTLQDSGNQQWSDEMKDFIRQTLIHDAISRPYPRDMLKHTWIVGSMMQVVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEB5</accession>
    <name>A0A8H5CEB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1285" mass="142428" checksum="C258B3B02D96B25E" modified="2022-01-19" version="1">MFSSLTRGFRGFSVSPGPDVVSGDSTQEISRNVSTRSATAFPQLKSFQANSSLPSELLDGMGSLKLQEELLSHSSHSSLPAEGMGTLNMAMGALKIEDDNAMLGSFSPRIMNSANDQTSSSSRFDDDLVTLLTAATITATPADGSSHNKLFSSSCEAYQQASTSSRTYRPLEMSDVVEGLQAAVAARSPVSSPSRRPGRQFGSTAVYLPRRPSNQSPAGSPQPTTPNFLTPPASDPATTLRDQKEHLALENMSGRLAEHEDMMFGDAFSSLDAEQQDLKLELARTFLKSSLGEITQLLSNAHRRQKSAARRSSSDSASKVEQLNNQRKALHERLRSLSVKIAALDAFRVPKAPVRINADYVYNSDFPKLDQINQVLILLAVICNMVIGLSITQCNFLVGVVVLLVKLGMSTGGTHDSSISYSPTPSQNTIISDMPTSLADALKKFGVEGSFDMYAACPTCNFTNKATMLDNNGQSHYPETCANLVVGESGKSICGTGLLNRRSNGTAHPIKPYLVSSFHDYLARCLADPAYLGLSNKAADDAYEAINSGTACNDVQNVFEANFTSDFKGPDGSLFVNRGAKIRLAFSIHTDFLNPNGITHRGPTQSIGVISCANLALDPSIRYLPEYMYIAGIIPGPKEPNVDEMDHFVRPVIEKFATAWKPGLKVSRTAESELETAVETGIFLSTNDLPAARKVAGFQGINSEFICTVCRLRGREQVMNTNHSHWPTRDVNELRRLAEQYRDAQTVAQRKSLFKQHGVRWSSFWMLEYWDPTKMLVIDAMHCILEGITKTDSENFKYAYDWPWVDYSDDLGPPGRTLEEKDVPCVAKVQQALCISLQGDKSLTLEGLWTRLYNKPNLNSLHFVVHNLGLSLALNDIREEVADLYLKRVTQKSKSKNPETRFPFHKEANTKSHLVAILINWRLKQPMHASHNLPVTGTHDTLAHIRHVIATTQTPSWVNSVPKNYGDADAGTLKADEWRTLSTIYLPIALVTLWGDEHSPPSQDPAVLQSVLDHTMWLFQAVMIVCRNTMTTDRADAFREFVDKWVNNLRKVHPHTREHAARPNIHAAGHIYDFLIRYGPILNWWCFPFERLVGTLQKINTSDHIGGVMESTIMKTLARTANIRRWLRRPECPEAVKQLKVLFDKCFVPANAPPPQEENHEMKGNFRAYAKHKGINFSGVHTHSGNSHIIYRPVGSPSAIAGQIEVIEDMSAERGTPILVHVRPFLPLVKPLSDPFLRYPHFQATTYSSQLSDEKDIIGLDRIISHAARFDYSYGRSVLVDLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CH12</accession>
    <name>A0A8H5CH12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000167">
        <property type="protein sequence ID" value="KAF5341328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CH12"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5341328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33628" checksum="4A36F3C970B5C066" modified="2022-01-19" version="1">MTPSRYQLCLMIPSSKTSSPPLKTQNQEKLAAVLAAIELSDEPRLRQMTGSGSDCTSTVEEEEKRRTLTRIHELAQQHGLSLDQVFSASRHRIRIVTHLEFLECANHDVTNSQQCLKKATKTCSQCRLVIYCSEACQLQHWKRHKLDCKYRLRSKDWRPRWLEEQRSPAFIHDDQEAAQRDSGINRRLWGTMSAIDILNLEANEGLAASLSRNFALAFATSGDIRNVIRTVNVLPEGYEGTLDIVINDRDEMVQCRNLLLLMTLGMLPDVVSSDCTGSMVWAPATHLCSPYVGKSAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKG2</accession>
    <name>A0A8H5CKG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKG2"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="30176" checksum="7BE1EB75DA59598B" modified="2022-01-19" version="1">MSALLNKAGKKLFEKHLEQYAPADPLYETYTDPKGRQKRRRRDIPPGLSKRDAKILKSIQRRAHYLDKGFSLCGLRFGWTFIIGLIPGAGDAADAALNYLLVVRKARQADIPTWLLRRMLLNNAVSAAVGFIPLAGDVVLAAFKANSRNAALLEEFLRIRGEEFIKLGVDPNAANTAATPAKKGNDKGKTKEVAKGVTKADAEQVKPGAGVQKGDKVLLDSAGSGQVPGGLTSITADTGESSGSGKSITRKGFGSFFAKKAPEAPEKGRFVENVDNKIRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL74</accession>
    <name>A0A8H5CL74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL74"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5343847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="38681" checksum="4810F166011DEADC" modified="2022-01-19" version="1">MWVIQFPDIAYASALGFAAVGANNGHDGFSGRSFLNNSDVVEDFAYRSVHTGVVVGKEITKTFYGYEHTKSYFLGCSTDFDGVVAGAAATEWNKLMDDFSYIFSLTGTPDAPSFLTAEAWVNIVHPDILKQCDTIDGVDDGVIEDPHLCNYAPSPDIVCSRDSNSTSCITPEQADTVRKVFSPFFIGDEFIYPRLVPGSEIAEALSMVLAGDVITFSVEWFKFVINSDPNLDVKTLGPSDWKKSIAQDPFKISTFKGDISAFKNRGGKLLSYHGQADSLISPESSEIYYDHVSSTMDLSTSRMDDFYRLFRISGMVHCFTGPGAWNVGQGLFGDTSPESDYTDPEKNVLMAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLT5</accession>
    <name>A0A8H5CLT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_011113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLT5"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5343027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="543" mass="58697" checksum="8575467F0B6AD79C" modified="2022-01-19" version="1">MSQTLPTMLEDSHNGHGQARSPTKSSGHHDSESQSIPMTTKPTTTTTTKTTKAPYSVYSKNEKWFIVLVIAVSGLFSPLTANVYFPAIPAMAKAFNKSTELINLTITMYMVFQGIAPMFFGALADYVGRRLIYASCLAILSLSCVGLALCPTDAYWLLMVLRCVQATGSTSTIALGAGVIGDIAEPFERGGFIGTYGVGPLVGPAIGPVIGGALVGSLGWRLIDILVPCNSRRNSMHNDIVNPPRNSPSHRGNGSILPPPLLCPIIPIVAGYKKTSASGPTEEDLETKSTKKKFRNPFTLLLSPDISLLLFFNGTVSSVYYAVTVSISSIFVKIYPFLSEIEIGLCFLCIGGGMTIGSIVSGKILDREYHSVSKTYRLSKMGDDSGELDVKAARDDPDFPIEYARLRATAYYMVLFIGAVMGYGWCIQEVTHISVPLILQFFIGLSAILFLNAVQTVIVDLVPTQSSSAAACNNLFRGVLGAVLTSVIDLILNALTAGWTYVLLGGICALLTPLVWVVIKIGPTYRKKRREKEMWEAEKGMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM47</accession>
    <name>A0A8H5CM47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM47"/>
    <dbReference type="OrthoDB" id="3352225at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="385"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="756" mass="76530" checksum="4273F11A14B69FFA" modified="2022-01-19" version="1">MADTPLFIPPLMTPAPSDGSHAHGRSHSRSHSTHASPWVGPGSSLPPQGYHPSNQWAPSSPMPAQPGFIPPEARSHVPPGGGGTPLPSNVNVEFMGGYPNFAPTPFAGNASLPAGGGGGGMGGGMGGGMGGGYPGMTPFQAPMQGSPWSPPGMAPGMGMGGMGGMGMGTPYMGAGMGMGGMAGSMGGGMPGMGGMGGMPGGMGGMGMGGMPGGMPGGMGMGGGMPGMGGGMPGGMPGMGGGMGGMGGGMGGMGGGMGGGMGGMGGGMPGGMGGGMPGGMGGGMPGGMGGGMPGGMGGGMGGGMAPSASAPDPFSFGQMAETLHSLHPSSRLTGSTGDRLPPFTPGPGYGPVLTPFQLSILGVLPILNPLLAPPSELETDETNPYLKWNLLFSSAMCQRSDDPPHVSWSRGRTDPATFPRVTSLTLIPSTRSAAHLPFTVTINASNPDAGVTCGDIVESLSQALYSRTSQSVFGILTSERRQVVAHAYRFNRSRSPGVPGGVLGEGMRRIDLLGGEGCWGGMKEIEGMREVGVYISNRRKALTDLSNATTPGGGVAAAAAVVKPEGITKRADELPWCTYEWYNLTSYPMTQEEARVLEERQQMVEREHREEGERRAREEGERRVHSSSRDGRRRHASSRADRDRGGIEVQPSAGGTASGRATPSQAPSSRPLSTATVTSITPTLASSMAPPSMARRSSRAATVHTVDDDDDDVHYIHGHGGEDEDGDSWTDADVQSARSGASGRSSRSGRTSRNNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMM9</accession>
    <name>A0A8H5CMM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000122">
        <property type="protein sequence ID" value="KAF5344612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMM9"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="287" mass="30426" checksum="F62752D2517A0AE6" modified="2022-01-19" version="1">MSSKLNQLANHFASLHVPGKPLILTNVHDCASTNAMLSLRPEIQAIATSSYAVASVNGLNDQTLTLDVHAEALARISEVIKSADPAANNGLGIPLSCDILDGHGSRLSETMKKIIEIGAVGCNIEDSYYDPATKKTKLYSVEEMKNRILQAKKVATELGIPHFVFNVRTDASFTHDRSGQDIDEAVARGKAYLATGVPTTIFVWSGGAPGGTSSESVRRLVKEFDGRLSVLLNRKDVGGLSVDELTKLGVARVSTGSLIFAQTTNATKALGKDILTGGYMGTLAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMZ4</accession>
    <name>A0A8H5CMZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMZ4"/>
    <dbReference type="OrthoDB" id="3254135at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55566" checksum="4847004E3275BDC9" modified="2022-01-19" version="1">MEQTDNSPDQTGTGNQANILSGAHDLNIMGSTFTTIGRDANYTYNSYLPESKPKEITADDLLLQKPLAPDVFMGRSHLVEEAVKFLCEANQVHIAILGTGGIGKTSVALHIMEESLIREKFAGRCYFIPCEILIDATNLIQGLVQAIGVQPIQGKGSYELLLDYLKGCQESLLILDNFETSWNSKEQMEIKNLIERICSSRLVSVIITMRGTDGPGQIKWRKLGGQSGLPPLELGPAKEAFCSLSSDGNYAIKEDDPMLEKLLIQMDGMPLAIVLIAQHARELPLKNLMEMWNIQKTAVLKRIGGQDNRLTSVEVSIELTLNIVREKLSTTGLDLLRLVAFLPSGIPDWLENVPKMLGSLPDTTMQVLTLKKSCLIYEANAETLKMLTPIAEYVLKVSDITENHEKQIWEFYKSFIDNLSENQIDEDIKLGLHIANIFKILNIQIEKSFETSHMNVLNQLCHHSQYFPGLVPLVEKYLRWQSQMSLGDQTELMFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMZ5</accession>
    <name>A0A8H5CMZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMZ5"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="23793" checksum="9E4788558CDCD8E9" modified="2022-01-19" version="1">MTRVWLIGKFRWILLPIGLLATAALVAGFFLVVHLPHNSFDVVHDPTLRLVFGVETCCAAVADVLVTFHLCYHFFQFRTGIKRTDKLVQKLIQALVTRGVFVTMGQICVIATFYAGVGQLYWMTFYCNLSKLYAITMFAILNSREKLRRIAGDVVTDGDFSYAMNSRIQTRRAENTISFNHPESGTITENDDHRNEQQKVKVFVITPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNS4</accession>
    <name>A0A8H5CNS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNS4"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30710" checksum="49C4187A402D6130" modified="2022-01-19" version="1">MSDELVPITSQEHSQRCKALFLQRRWEFKALNAGEELAAYAEEKKIDYEKLLGLWPKNMPVITVFTNYAERFPKNVLSATNHSLIIANAASHDKRLYSQDAEARAGMSFVHLLVIPRRDKVYNAVSLDDSWIITEMKSHFRDFWSKPDGVDIIIQAVSEAHTIFVRKEKQLKAADTKTLKKFKKTLRKTDQSRKKLTKRMRTVKFDDFFFGFHCMPNASVGYLHMHVILTPMKFRKHSTHRNDWKTIPADVVIEVIDEEKGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPN1</accession>
    <name>A0A8H5CPN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPN1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39265" checksum="579FB483DE8D9974" modified="2022-01-19" version="1">MISPSECKLDIIVIGGSIAGLSAAYFIQRAGHNVTVIERCDEEYFRAQPFSGLRIPATASRLWDELPGLLDLLENRGVQHPGSVLRQGEDFQLVGQMVYGDHIISDLGANGYRIEYSKFWEYLYQLCLGNQVKFMFHLEAIDVITAESLHQPAKVITSSGRHIAGDLVIAADGHNSKFCDLIEMESNDEDEGVLEESRKWNTYVSSSVRGIQRKLVDDLDGQRILVEWWTRLYFSSVFAHSILKIWMLQEGKNNYVLNTYYSTLETTGGDMEWDSKGSSLSRPPELVSLQHEPRFQKLLSMSEICYRNCQKSSTPPCFNNSTNQIVLIGDAARGSALVNAILQAQTNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQJ4</accession>
    <name>A0A8H5CQJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_009650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQJ4"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="415"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5345203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1257" mass="144253" checksum="7970AE814FCAB43C" modified="2022-01-19" version="1">MPPPRRPRPTAGEVSWGPDFHTPSSSGSVGPTPSVPSSSTPLPLKRKPTQHNQEEPKTKRSKSISTSEQTSTLRDQLPVFFYEPRQDLEVWTEEEVLDLFGVDFDEDNKPEMVISDFSIYDARRRNELISLDTLARPDGKERNFQAVGKVRVIQEYEDDDGENNEEGVYVILKTIMFFEYDWNEANWWRAGAIETPLAFYVLDIPNPRYQDFFRLFLTPRVIVQKIIAAARRDNKIRDEDFKNDFETQSDPFGRKFTAGDIQVARSYLRPALKELNLLARFKDVPLIRALLPSRSDEDNNGMDNNGGRRWRNHRINIDRRVLEYPNRTCVVESIGALADGLIEESVLTVGPRPKRVDERMEKVEKKRKAHRQRQRLYRLLDVARHDPVVQWDKEDIIRKGGKRTRCLSSVRVNGIVYKPGDDIVVLVGHDPAKKAKKGPQSLIPHESEIPEDGQVADYFWFARIIYLDHEAGNLSGDTGIAHIQWYNHGSQIPILEELHRPQELFLQDLCGPVPLACIIAKVKVKDQPTEAGLGKLHENDFFYRFVYDPVTASCTTPDTEGMDKAKSDPRPDACHVCDLREKIEERAIPQPIHERKNGKAVFTGVKYDNVSCHLHDFISYKSYEVGGSDLGYIVDFHEKGPLIVVRKVGRIRDVKVLPEDYFRDERHLYITDETDIIQADRLVRVIHVAHLKLLKNEDGKDTREEWISRSPYHFYLKFCFPKMKVTKRAWEEKKSCRKVAICATCPEAEARRWEQEREVRAYYKQNPLIATDLFGGCSAFATGFALGSQCIKVKYAVEIVPSAALTYRKNSPDTIVINQCMNEYLRYAVKSQLEEFKDMDKPKDLYHETEDIPDPPKRGEIDVVLAGFPCQGHSDLNMYKKANDSKNNLILTCLSEVDRLRPKYCFFENVPGFLSYRLNAVQADERRVEGGIEQGGLKFLHRALLDMGYQTVFANLEAGHYGSAQSRVRFFMIAAQQGLPLPLLPQPTHDFPSRSLNIKFCDGSAIQPIRTSRNVAAHRAYTVRDAIIDLPSWDWQHPNFNKLSRDEKDELRKRQQDGIPAIPYQGVPHPTWGKDVQHHYVENAVMSRYTVDCRPAGRNIDPDKLQHFTKQFLPKVVESVYKIPPGGDSRSIQPYLGQFQLHNARSAQARRGNISGYYRRLDWNGHFSTVVTNAHPTAKVAKVLHPDSQRMLTVRELARAQGFPDWFEFIALEDNVITHRHIGNAVAWPVSKALGRSLLDALVVKWQQREQIVIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQS9</accession>
    <name>A0A8H5CQS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Het-C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQS9"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="61958" checksum="281CC5E22DC42F1E" modified="2022-01-19" version="1">MHRSQGRKQDEYEAYRLLGQALHTLEDFSAHSNFCELALISMGHSNVFPHVGDQVRIQAHNGKWVAPLVTGTFGSSDFIHSLLGEATDHLSEASVSDLNKQLDKARSSDQARSGPGGGGPTSALRTLFSSIPGGEGNEMSRDMDSIERIRAGPAQGGKRPEDMSPQELHAVLWQVLSFRDSVVKKIEKTIEKIPGLGSLIEKLMDSISVFVFTTLEPFLKPLLQSATGGLQTVSGEVIDNHDQYEVFNDPRASDPTHSFLSKDHFNLILNEPAGQIARVVVSHAVGLVVKAWDDSSVNVHQVTEDILSCLFHPDFHDSNSKIQREMMQSMHNWIQHLGGKQHEVLNRLTKDAVRNHKNIRLGGEGGVPEAQGSYAYNQGIQAQHNLQGYLGQIPGVSQAQSLLGGGQGGRREMPGSDMPDFPGANTHGPGHGHGHGPPHGASPILSSGEASSYYGGNNPSGPPSFPSTPGHSSYAAPSGPPPSFPGTGHDGYNPAYSSPPSFPSAQPDGAGWGGGYAPPPGPLGPGGFAPSSGPPGFPGASPYGGPPGGTPGFPDAQPHHHHHHHQHHQPGYPGSGYGGGPPGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRU9</accession>
    <name>A0A8H5CRU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRU9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="132" mass="14313" checksum="6373046DCABD1B6D" modified="2022-01-19" version="1">MSLSVLVKFLVDPNIVLLKSPSSQLHQHLGVIVRHRWPFSASASRAGGHTDGASPTLLGINGVGIQGTEVCDEWIGWLLKHKTPKADEDSRTTRLFSSRPMAIASLLLDTTDDSDDDALEWGFGYVPAGSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS90</accession>
    <name>A0A8H5CS90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS90"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="224"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5346920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="33841" checksum="28F7CA1A22E5DAAE" modified="2022-01-19" version="1">MKNVGLQMSSGAVSGLAATLVLQPFDLVKTRVQQGFVQPATSGFSTVPPTLYARPTIIQTAKDIVSENGVKGLWRGTNASLLRNVPGMAVYLTTVTQLRTFMATSPYFANVLTENVGARKAGESVLPKLNTQGNLISGAVARVSVGFLFNPLSVMKARFESNMYAYTSMRSAFLSIARGGPSELFRGFSATSLRDAPYAGMFMVFYEGLKRHASSVLPTDSPGETALLHSMCGATASGLATAATHPFDVIKTKLQVLSSEERYRGFTSTVRTIWKERGVMGYLDGVSLRLGRKVLSSAIGWGVYECILVVMYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUE4</accession>
    <name>A0A8H5CUE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUE4"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034231036" description="Fungal lipase-type domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="154"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5348060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="40737" checksum="098C2339E3176D05" modified="2022-01-19" version="1">MHSTLALFTTLATISTVLVYASPILPKAISSDNVVVPIAPAPRSSLVSSASSGSLDNFSATVEVIKGSVPEEKDLETRQTGPFTTLTTAQIASFKPFSYFAAAGYCDPSDILRWGCGANCKANADFIPTASGGNGGSVQFWFVGYSPSLDTVIISHQGTDPTEFESLLTDADFFLDTLDPTLFPGVPKGVEIHNGFGEAHKDTAQSVLSAVQTTLSRHQTSKVTLVGHSLGGALSLLDSIYLPLHLSTTPGGTKITYKTIVYGVPRVGNPAFADYVDQHVDLTRVNNDNDLIPIVPGRFLGFAHPNGEVHIQDDEKTWVGCPGHDNTSPLCTIGTVPTVFEGNILDHLGPYDGVEMASFTCVEGSEEQAGLGNGEWMELEWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUJ3</accession>
    <name>A0A8H5CUJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000087">
        <property type="protein sequence ID" value="KAF5348185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUJ3"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36486" checksum="FDEB1B5BACC0DB04" modified="2022-01-19" version="1">MTSRQTRSQGSVPDIPLPTTSRHSSAHPSGTQTPTPPISSTSQAQPLDPLIQNPLPFALDPIMSDAGENTRTNVRDTVPTPSLSPPSTPTSLVALSMPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFCVNSALQVIRHQHFKSSGLHPGNTVKLACFNTITGKIDDKIMIHYIEESDAIELIKKLKQRFDPSSTVQESNELWKLFNLCKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYTAVDLIARLKKEFTNYRLSNAQTYPSKKSDKKSGSTSQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUW4</accession>
    <name>A0A8H5CUW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUW4"/>
    <dbReference type="OrthoDB" id="3244905at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="426" mass="45963" checksum="7608B04415B47129" modified="2022-01-19" version="1">MVFRIPTHLEYFVPPSAPLIPADTQSALTHPWRGKLVVSGLRASDIEGSQEIRVTAVETDGETPPSSSHLWPSSLIFTVTNALPILKQLQDYIRTAAQQGRPVPMCTFMPERQRDPDAHTVNQTLFRSLSRILWQDQHVAVVPFSASPKLSHSPYPNRSMGILIYPASNSTTMLIGAIFLNPSEGLPDFVNAAQPSHSSPSSLSQLQVSSSQIPMPSQTSYPHSYSTPFGHGRDEVPISPTVLNSRSSTRISSHLRASSSRQRSASESFRRHASPAASYGHGALGHQSQSLSPTSEHGESVNIRQFHHAYPHAVPSSSIARLAGSGGGVDPYRHPSYRSMSPVSSISGMPAHSGAPYIPSSDPYAASEGQYPQMTNPSPRDSASPTVPYPPEGARSSSTRSYTQTAYPLPPDRRGSGSSTHSPYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVF2</accession>
    <name>A0A8H5CVF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVF2"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="75" mass="8384" checksum="B0E8F158EDEC73FC" modified="2022-01-19" version="1">MSQKFIVTFKDSVSKEDLKKYKDQVKDAGGKIYQEYDGVLTGFAAEIPPQTLESFKSLQGDVIEGIEPDGEVRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVH6</accession>
    <name>A0A8H5CVH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVH6"/>
    <dbReference type="OrthoDB" id="3235673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37921" checksum="E43151E8A8AF6D64" modified="2022-01-19" version="1">MTPPTPAPYPNLSFNDGNLVLLAQNQYFIAHQGVLGRHSSSLDAALKALQDSPRLLQGRPVLELQESPEEVYYFLSALYDGISHLVYDVQTFNVISSLLRLFTKFEVHHLRKEIIRGLSTIWPPSLAQWDIREANATNSFGVYEPRQTIPHPILMINLARSINAPELLPSAFYDLSRNSPSQTMAGYFCPETEHVHQLSQDDLFNLLKGREHASRFLSTFLVNFLEGRLPCQDCVFKHQKDASLRRRCLAAFEAITFEILRDVNGVVCQRSSDPLFAIMDTELMQAKADSRQIINMRPCDFCRADYGPVVDAAREEFWNMLPEWFGIVVSNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVV7</accession>
    <name>A0A8H5CVV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVV7"/>
    <dbReference type="OrthoDB" id="2124139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="36960" checksum="033D38259FBBE4E5" modified="2022-01-19" version="1">MIKKNDIKKRLKTPRNARYACRNSPSSGLRRRKHKASQIELTNQRFETNHHRTEFSTPPSRNCHCLFDSYDYFIRYIPEVHFVNYGDTNEPYNKLHFKYIGLQPEERYSPIPALFLIHECRVRSFHPFKSIQELPSDFQWADWVITSAAISPDESPHQDNMISANETGGGYDSTRTATGNSPGTEGSPYLEGMYHRKHELGSHNPLSLDRPPAATPNYPSTPSASFSVHPDSHSDSHLTLTAHRLLTVSPPSPRKNISKALAQYGATEDALLSDSLDFLGVEENGDFVSILDDKTKEALWRGWSRLNTKKTREKEKERKNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CX18</accession>
    <name>A0A8H5CX18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000087">
        <property type="protein sequence ID" value="KAF5348187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CX18"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="83" mass="8570" checksum="71040661F6FA9EA3" modified="2022-01-19" version="1">MVCNLQCYAKGVCSLAGILALLINNNNNKNKNTTQPSKSRMNINTVTGPGGSCLTFVNGLFRAGSESAGAGAELGPRILRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0A7</accession>
    <name>A0A8H5D0A7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0A7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034670026" evidence="2">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="496" mass="53524" checksum="2D3BB32E3CA23515" modified="2022-01-19" version="1">MRFSPSLTISLLWMLTTVHGLSINHFIRAEDASVVAADNNLEARQPMYFQRDIEDDYGKGHGHGDHGKSKDGKGKHDHYPRDVEDVEEDDFGKGRGHDKGDKGHGHGDHGKGHYPRDVEDLEEADFGKGDGHDKGDKGHGHGDHGKGKDGKGNHGHYRRDVEDLEEDVFGKGHGHDKGDKGHDYGKGKGDGKHGHYRRDVEDVEEDAFGKGHHDKGGKGGKGGKDHDHGKGKGNGDGKHGHYHRDVEDLEEDAFGKGNHDKGGKGGKGGKDHDHGKGKGNGDGKHGHYRRDVEDLEVGMTSVMKTIADSIFPLFPSSVQEDTFGKGNHDKGGKGGKGGKDHDHGKGKGNGDGKHGHYRRDVEDVEVSMTSVMKTITDSIFPLFPSSVEEDAFGKGNHDKGGKGGKGGKDHDHGKGKGNGDGKHGHYRRDVEDVEEDDFGKGQGHHDKGGKDHGHGKGDGKHGHYRRDVEDLEEDDSGKGHGHDKGDKGHDHGKGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1I9</accession>
    <name>A0A8H5D1I9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1I9"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="445"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="643"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5351384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="708" mass="79375" checksum="5014EE4F932EF977" modified="2022-01-19" version="1">MLCIRFSKQRRGTSLSSADLSESSPASRSSFQVGQQHHGSVAEIHSEKEQTYGTREPTESSRRWRFSWRRKQSRKRKAFDGCSNSRPSSDSFNTLVPSADKQSIAKSSTDHYAKTDSTGRLKFLRALMRKHDLDYYLVPSEDAHNGEYIAESDQRRRFISGFTGSAGIAIVTLNSGAFLSTDSRFWIQAEEELDDNWTVVRSGYDWTQFLVNHVTSGPKGTRIGVDPSLITYANTVYILPKITAHDSSLVFPEHNLVDLIWDEDKPNQPRNLVFIHDLKFAGEPASSKLARLRILIRSQIEDDVGLGKSSQQATGMLISHLPSIAWLLNLRGTGIPYNPLFHAYLYINLGNGDDETVLFLDSSQAPPYIDAYLKELGVKRKNYDEAWRFLRSLNSSEKEDGSQKEIIITPKTSYAISLAIGHENSLTQFLASLSSTLTTTFSASSRLTEFSAAELLTQYRISQGKGTYRDQKEPISASGSNAALPHYVAKKGTARVLDRNIPYLNDSGGQYLEGTCDTTRTVYFGNVKPDEEMCMAYTRVLQGHIAISTVIFPPGTSGRQLDVLARRPLWKVGQNYGHGSGHGFGTFLTVHEGVQSFSSDVPLVPGHVLTIEPGCYKEGKWGVRIESALAVTHANTKHGEADGWLCFERLTVVPIHTRMIKWEMLTEEEKIWLKEHNQKCYELLSPHLKDDKRALCWLKREAELACKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2I9</accession>
    <name>A0A8H5D2I9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2I9"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5351533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68006" checksum="312687600518857A" modified="2022-01-19" version="1">MRWALGESDGRHPESTESEPNLSCLLSVTYPHHHLLAFRGSSLLVGSFEMVTTEPFKCVERHQQEATKWADEFRQALTLMENAHTLDTNLMELPRRKAADPAKAALANEIARLLYPDLAIREDSLGPIIRYEKDLVKLRAYIQAQITQQNSESISTSVWAERILRLGPWDEGNDPVSLEGASSLPMPVQISDGETLAPFFNHLRMGGDDSIVGDEDAEEKLEPFYDVHMVEFPKGVLYADRRMDLCKMVVGPTHIGGLMDSLESNPFTEHFLLGNNIIGPLGAQHIAAFIHKYPDRMTTWYLAGNCIDGPSFKLLVDSLVKSPPVTNLWFKRNPLGPSAAHDLFRLIIQTPQLRTLDLDQTSLGDAGVASLFSLLAEYKSDVPLALRHIYLNGTGIGEAGAKAIARYLAAESCTLVSLYASNNPLGDKGATALAAGLSCNKTLQRLALSSNGLKDHGTSILLKSLLNHPALRLLDLVSLIRTVTTLRYLTLDLVPITRPHLNEILSAVAESDLLYFTATPLEPQGRDIVSVKAGQTAVRLREMVAKRLAENIAKEYDGISMHEFYGDGKRFLVSPEDVRYIDSVYRNRDAQMARRGLKKLDKWWQEGMGRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3T9</accession>
    <name>A0A8H5D3T9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3T9"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30528" checksum="8E072F27324EAC08" modified="2022-01-19" version="1">MVFISVHADNGGDVIFCSSDDVRFYIRCQDLEYLTEGFPAGDQISSSEVVPLAEKASTLELLFQFTQRNTPLPDLDDVNFKQLMDLAEAAEKYVVHSAIRVCVMRMKDFLDVEHAEEIFNFAARHNGHESLIFAVAPMFVGKELEDVAYIMPADLYIPWSMYREQWLKILSHLTCPLDVFNPNSKKKLWRTRILAAKREIMANPQLIHHLEELIELEKDTRGPKGDDDMNAVLFLWRDGIVEQVKRMRTLKSFVLEHRQRKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4L9</accession>
    <name>A0A8H5D4L9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4L9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="66" mass="7621" checksum="D586363AFDFB7F89" modified="2022-01-19" version="1">MSMDLSTRNGVDLGSVRKKTINAIRTILKTIFSTEPIFNEDNMQMERYNAGAMRTNRIPDLLRWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5I0</accession>
    <name>A0A8H5D5I0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5I0"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5353093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22181" checksum="3BB9784D866BD6EF" modified="2022-01-19" version="1">MQVNRPCLLCGNPTSMWCSRCQNAFYCRPEHLNADWPRHRNECIPASHPAAHSMNMIATPPPAEPQYISVSAILFTPEEERPRIITVNCRPASRSSHGMCPLPMVQQYFPDGQTEGIVLTQGLNGEGLRFPLHLWYSPTALQRSSPVNRSIFNITSGSAQKSWCGPVVVLKYNGTRRQGYTDAGSNDLPALSAYFLAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6I9</accession>
    <name>A0A8H5D6I9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6I9"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034592193" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5354420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="274" mass="29822" checksum="7599230C48AAE1FA" modified="2022-01-19" version="1">MAFKSFLSFCIVAISALIVSADHGDLGSRAIDWNNHQWMAPGPNDLRGPCPGLNTLANHGFLPRDGRNLNMSVILDAGFNGYHMQPDGLALAVKAATFSTDDPFTFTLDDIKLHGTIEHDASLSRNDFALGDNVHFNETIFKTLADSNPGVDYYNTTSAGQVQQKRLADAEIANPNITNTAKEFFIRSGESAFYLSVMGNPLTGVAPKKFVQIFFREERLPIAEGWRRSDTPINGSTLGPLIDAIAEQSHWTTSGGCPWIRVGPESATTLVQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8T2</accession>
    <name>A0A8H5F8T2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000376">
        <property type="protein sequence ID" value="KAF5328000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3259294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="195"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5328000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1659" mass="189796" checksum="4BAF1356433A04E7" modified="2022-01-19" version="1">MKVYDVLPPPPEDLDEVLAIMFTGPCKPTEKDYKRTPMLVRRKEVFKALTWLRLNHPAYQDIKISTDNLNKYPEDIPPVTVAFKEMESEGNRIPEGTSTYDNELEIGTETGSIPFVVHGITGEQLQNTSVELQKAKALAYLKSQGKFLAVGHSEKSSSMFNNPLLYPSIFPWLFPYGMGSIGMTTLKSFSEKSHKKYFMNYHDKRFQTDPLFNFVAFSHEQVKQTTTNGFALTQKKSFSTIADRILNLNPHVLNSLIDKLSQGKRVQPETEEEKLCYDIIQDLDHVGGTVKGSMSSKKFLRTKLWSLISYLGAPSWYITFAPSDQTHPLCLYYSITDENFDINLNLPNDERTRKIINNPVAGAKFFDFMAQMFIKHILGVNTDHDGIFGKTSGYFGTIEQQGRLTLHLHMLLWIANSMSPQQIRDAILKNEDDFQRRIVEYLESVHCGDFMTGSQEEVQQNVQAVSENEDYTNPLYSLPQSPPNCLCTSTEDCETCKAWNDNYQQEVDDILSRTHIHKCKSTLTRQGTRKVGKDYLGCLDNKFGTCKARFPRETFPSTQVDTETGALRMKKTEAWINTYNQTATYLLRCNSDVSSLLSGTAIKAVVLYVTEYITKWNLNTHVIFEVIRTILQRNTEMLTGTLPRHEKARKIITQIVNLLSVKMELGAPMIAMYLLDKPDHYTSHEFKSFYWKDFVSEAHKFWLEPDEVQSNKEEKVVVIRHKGRIVGFSSIFDYIYRPEDLNDMTLYEWVCQCERVKLTAEKTEVNCSDDESSEYYDSGYSSDEEDTYAHQKTLETEWPSAKNHPKPLEKNVLPKNGHPFVHDHPLASTHYLRMHNKKNIVPNFIGPSLPRKNKGDREYYCSVMLTLFKPWRTGEDLKIKGESWDRAFLDYQFSTQQEFLMENFELRFECLDSRDDYHAQRKAQSLGIDPSSLEPEFDDGVHFDPFKCSDDHIGVREQRRQLDMQEMTDLLVNMGWTNAKCDLKSRIPASFDYPFKSSNAWRLEIAKMKGNVITDRLKQNKNKPNTFPNKFPDQVEILDQHIFEEKFKSNQTKKLIDDLCIKFNLNLEQERAFCIIANHAVSSISDQLKMYIGGMAGTGKTQVLKTLREFFKQRDQSHRMIVVAPTGTAAALLQGSTYHSVFGINSSEEDEVSMLSCKDLYKISAKMATALNQPLLPFGGVSMIFAGDFAQLPPAMGGESVSLYSHTIGSSSSDQQASIGKYLWHQVNTVVLLRKNCRQTGDSDRDIKFRQALEHMRYKKCTTEDITFLRSLISDPSNESRSIDNPHFRNTSIILTYNKHKDVANELGSKRFAAETGQVLTHFFSDDEQVVFDEPPSKTHDRKRKRRKATKHQIDDQVQQQLWKQSPSTNTMQIPATLSLCKGLPVMIRFNGATELCITKGQEGTVHGWQARKGKHGQLVLDVLYVKLEKPPTDVHFKDLPLNVVPIIPNTRRINCKLPDDRIIQISRTQVEVLPNFAMTDFASQGKTRDPNVADIYNSRDFRAIYTALSRSSSADGTMILQGFNVNHITGGIGNKSGYRQELREMEILNDITKLRADHKLPHSIIGDLRGSLIQQYRSHFGNRHTPEELHDSLVWDADEKFESTLDKEISWKILGEKEKTKPPAKKKQSAPSYALFGWNPTEMVYSSHDSDVISGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9T4</accession>
    <name>A0A8H5F9T4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000346">
        <property type="protein sequence ID" value="KAF5329110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9T4"/>
    <dbReference type="OrthoDB" id="3351617at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="327" mass="35403" checksum="28C98F16E5F3DDEE" modified="2022-01-19" version="1">MIDPQLLFERCLYIGNILAGIIYGLEVYIAFHTIHLLARGHHTQSTSRLLLIVYISLLILSQTLALASQAGAGQLMWVEHRDFPGGPVAYFNSTGSSWNNLGGTVFVLLTNFMGDAFLLYRCYIICDSNALIVALPFLMFLGSAAMGIVALVQSAIPGSGIFAQQSVNFVIPWVSLTAGLNVILTALICVRLLITRRDLLRAEVTEIKVYTSLVAILVESALPFSILGIIFAALLGKAVTVYVVLSVFWGGYAGLAPLLIIHRVALGKAWSKKTMTDVDSSRLIFATNTTNDSTLGVVSDLNETCTADLSRTTLRSEPGTRISDSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC26</accession>
    <name>A0A8H5FC26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000327">
        <property type="protein sequence ID" value="KAF5331316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC26"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5331316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="234" mass="26294" checksum="6CC60A9DC91E96DB" modified="2022-01-19" version="1">MATHPSIRDEPSWPSLYNPHSELSHIQHQDPIQPGATYLTDAEDVFRFTLYWTLVLYLPLFALLGLYAAFNLAFPPSRKRARGMDPFGDDAGNEDQEHAYPLNTLPPPTNRRNSNHFLSVNVGNGYQSLRSDLAPSFSSQSEPPLSPSRLHPQRVPKRINAGRTRLIVAFLVFLVFFSTFLIGAVLSSAIVGFVVFGLYKAGHFYMSSWIPFLWAAIQVFTGVLSVWPFVINII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDE7</accession>
    <name>A0A8H5FDE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000292">
        <property type="protein sequence ID" value="KAF5333025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDE7"/>
    <dbReference type="OrthoDB" id="3265539at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025314">
        <property type="entry name" value="DUF4219"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13961">
        <property type="entry name" value="DUF4219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5333025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="260" mass="29656" checksum="899564EC8D374B6A" modified="2022-01-19" version="1">MSDDSSSTPRFAKLNDSNYAAWSMRMEAKLIRKELWNDVVEVMIDQVDDKGKLRKPEDIEADSEQSKDPLVVWEDLKAVHRARGFAAFLSLKRKFLTMKKEKGQKMSAWIGEVKSQAFEMQEAGLKVPDLDIILGLTMGLPPSYDSLIINFDDTPSHELTLDHVTTRLLAEETRQLSCDSPTPQTTTTTNPKDLQYNVALGVKKAPLPVEQITCWFCDEKGHYKENCEKRKKWLESRKGSGRAMTVVEAEDEKEDDDYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGI8</accession>
    <name>A0A8H5FGI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_014808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGI8"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5335623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="309" mass="34304" checksum="67685D4590FE7C62" modified="2022-01-19" version="1">MPFDEVVLNDGNAMPTIAFGTGSKWKRQDVTALVGQAIDAGFWHIDTAAYYETEEYVGKAIRESGLSRSEIFITTKYPSPEHRTIPEEIRKSLKNLGLKHVDLYLIHFPESVPDIQIGWREMETIKSEGLAKSIGVSNFVLEQLQKVLSTANVTPAVNQISLNPYNYRQMKSTIDYCKKNGIVVEAFSSLAPITQYPGGPVDEALQDAAERLKITTVQVIFLWLRAKGLSIVTTTSKKEHMEEYLSVGDLPPLTPEEVEAIDEAGAKGPPSTLTLAIRRGYKRAAGSPVKALLAFGFASFMMYQGMRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIR7</accession>
    <name>A0A8H5FIR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIR7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="24753" checksum="75C2CFC135799E9D" modified="2022-01-19" version="1">MEYNPLGMPKLAARCPHLKYLEVFETWCMSDRVPTGNIMFSLLQILDFTCQHSAPLGNLLPYLHLPNLTSLSLRMDCSRPKKHTQDFLNNLRGMLEQSPQIRSLRLEELMFSDSELIEILPLVPSLQSLALLPRRYYHSLYTTSFFNALNLTIQSETTPVLIPGFTNLMLELQDITWFGEPSLRQRMAEIVSMLESRRASLRHFELHATIPDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FK90</accession>
    <name>A0A8H5FK90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000185">
        <property type="protein sequence ID" value="KAF5339478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FK90"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5339478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="64281" checksum="844A5576FF1D27AD" modified="2022-01-19" version="1">MNCDDIRTTKDIVTSCLTVIILCTWTSVHPNVPNLCRSEHPALVFLDRAKIFFVAFVAPELMVLWSIRQWVAARRMAKRYKGISDDSVSYAYQRLILNGYPSVYNWTISHAFLALMGGFAYYDCTGKFLFHLWDPSFCQHFRDEDRPEREEQEKKLEELRRSARQGLSQTSSYQEVIISTSFLSASSRGNSPFEAAFSIPTNSRTCSELSTVGASNYTTYKSQSATNDNTPNGRPRTGSYRECLLEFCVASGMITTTEEEIWGTISSTDGLAKLATVMQLLWFIIQCIARGAENLAITELEFYTLGFATLNLTTYFFWWNKPSGFQYPIRVYDPREWPLRSPLAYSKLEENDSMGMITLPLTRSMNGKSSGFLRRSMESARKFPEAVSERIRKDYYPNDFKPWSIFFIPPLALTKLFNYALSGDALGAPEQGNLFTASTIKEPTGVYAAAYAAAVVLGLFHCISFMLDFRGFPSHPRDQHLWRVFSLLVTLLPLGLGAVHVFTHYRGVTGGGRQYGGSVPISPFIVFVFTIIYGAARIVLLVLAIKQLVDLSPSALQDIEWPGFIPHIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKD6</accession>
    <name>A0A8H5FKD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKD6"/>
    <dbReference type="OrthoDB" id="2877316at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66710" checksum="1AA67DFB02B99687" modified="2022-01-19" version="1">MTWGKQGAPESSTSVDPGNNLYLKPLDSMDSLGEFAAYLSDRRVQQPILIPPHSATSLQSTLQDREARIQSDLIAQEESGKQVQRIEQQQRTIAKDLLSPLPPEVLEEIFFQYLQLREPEQRRLRLRRGRNKGHHYDRILPVVLLCNICSSWRYIVHGAPRLWTLLLLSPYNDRAPPAALIAEWLQRSGSLLVDLAICPFVPTNDDEWASYGDVLVSVGKRLHSLEVPIVLLKNAAEQLERMSLPNLRHTRILPKTDHSADGVIDLRHLLFFKTATRIRIVEFGGYTTPGDVRTFLDFPFPTARITRISMMCFSVGLPMLQDIIRACPLLEDCALFCITRLPTQPRNLPLFELPHLHCIRLQFQGAHGVKHLFDGLRLPALKVLRLSIQMHLPPASSEEVLPHLSALHGRSAFKLQDLTLLGIGANETDNILDFLGRIPTLESLSLEDAPLSIPRFFRALRDDGNQEQVWEASAVEERIATTPAPIILPNLTKLSVVKHFRADPASLEWDPISSSDIDIADAVASRCPGAVVDDIETHRITSRPVTKRLRSFTFQAYERDLSEDAMSILMECRKKGLQLKISPIPNFPGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLS7</accession>
    <name>A0A8H5FLS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLS7"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5341471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="564" mass="61195" checksum="5AFA92701E2DE9D4" modified="2022-01-19" version="1">MAPYFLQNLIPRREKTEHARPLMQVLLSLTWLQWAQFWVGWLAWTCDAIDFFSVSLSVSALTDTFDRSTHDITTAITLTLLLRSAGAIIFGIISDRYGRKWPLVFNLILVAILELGAGFVNTFSQFLAVRSLFGIGMGGIWGLASATALENLPVEVRGLASGVLQQGYAVGYLIAAVIDLTLVPDKDAALNGDGWRSLFWLASGISLFAAGMRALLPESAVFIKAKADAAARGANTKNKTKVFLRETGKMLKTHWLLCIYAVLLMTGFNFLSHGSQCIRSFIFTFMNHCIFTFFPFFASRSSRSRILFQGSWVHGYMGTMGHGTLWSDRDLYPTYLKDSKGFTDHQATVATIIGNCGAIAGGAIAGWASQYIGRRLTIVIMILLVAAFIPLWILPSDFSGLAAGAFCIQFGVQGAWGVIPIQLAEMSPPAFRATFPGVAYQVGNMVSSASAQIEATGGEHQRTTLRQADGTFKDIPDYATVQGILIGVVAAYLLVVTILGPENHGSHFEKHKAAFEEGGGEDDAFREDEDGAVGGVKRRDVESGSGDGSGSLDEKREDHGVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNA0</accession>
    <name>A0A8H5FNA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNA0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="82" mass="9007" checksum="73E1F84F3B3C22A9" modified="2022-01-19" version="1">MTGAGTGTGEPRVRRRGGGAVDGDGEEDEDEDEESWGEFDFGVSEGFDALQWFKKTFIKCNERAAALVKTWLPASYLPSMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQN2</accession>
    <name>A0A8H5FQN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQN2"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="40019" checksum="AB8EC8A9D79BFEA7" modified="2022-01-19" version="1">MSKTHTAIATLSPGHFDAIQVPTRTPGPEEVLIKVEYASMIAFDTYINDLGYNIVPVYPMIFGFNGAGTVVEVGSEVGDLKVGDRVAAFTLGSSERKAMQEYTVQPRYTCTKIPDTLPLSAAATIPDNFATAYNVLFNPIYLGLPTPSSLPASTPPSLADKPIFIYGAGSTTGQYTIQLLHASGYTNVLVTASPTHHPFLRSIGATHTFDYRSPNLAKEIAEVLSSPTNPDGKVDLALDCVSALGTIARVAKVVSSEGKVALLMPIKDGDSVREDTLLKELPEDRNPLPKGTQHVYVRTFLYEQNEYLRENLMPKILPPLLEAGIIQPNKVRLLDELVGMLKERVAAGLDLLRNNLVSGEKVIVKIGGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSI9</accession>
    <name>A0A8H5FSI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSI9"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="21789" checksum="C17B0ACDF42C83EF" modified="2022-01-19" version="1">MFYAWSKLTILRYRTYPNLFGVSLYQPKNVELHASGRKAFKLSDVVPSHIPDSPYLSQIPCSWGAVYFPRHWREFHNYIALRLSELSQSSALSSSSPFLPLKTIIVPDVRSNRWTKSWKKYFIEFVYLRGYTMLYPSFPDYLSLSTNHHELGVHVTTSVSSRKQEFEVPLMSTQALALPPLLSFPFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSW1</accession>
    <name>A0A8H5FSW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3056903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1592"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1599"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1619"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1652"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1673"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1685"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1700"/>
            <end position="1715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5347473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1723" mass="194517" checksum="A3D7655B4B8516D6" modified="2022-01-19" version="1">MRKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPPEEYLGNPDSGEEKDNGNASDMDIDNGELGCPEVRTMPPVNESCEDKSGLQHLPTRRDETQLQTLKLFNFKSIAKAMQPSTIPTDPQSNVIPSKSAVVPSVQSTSHSVGNLQKPLCPPTTVASQTVPPSSSHPPAVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATRNCKGNNGKKNQKGSIHATTIAGGKESYKKCLGVLRCTNPQCQVITRPKIEKKILEAQWEMTSPHGFIVTSMLLAQKFANIETYRYETKKMTKGATAEVGWSFINQFHSWIQQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAELVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTAVIEAIAEAAHEHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTVLENAAQSLIKGCRYHFEKSVTRVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQRKMDSKLASKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDQSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMYKGSQAAVKAITKLRVLGPHLSPGKSQQQDISNCLGGRLRTGSSQFSTYPQWRFHRKSRVAGDATQRRAPMIQTSIAMGSARKWSLLAGYHLYSSSDQVWMKKAINQIGISLVNYTQAQKPQVQEMEWYTNLWHACSQTKHTFGGQSAVFSYDGMENMGYSQLVKGKIGDLLAGTTGYQPDGYQTVCAVYSLKGGIVAQEKFHEDCVKIALQKLDLQLDGTRSTTLTKPGYREMTREETVNWKPHISITEYQQTHSDSRQVVKPEPAHSYSPSPGPSPTTPLRTIPSSSPPPSTPLPILCRCGVENDGHRELIKQVTVQCDKCHRWSHLACLVNRMEPTIKGEFLCHVCDPASMLDTSSSQIIESLKQGVQLRANVAKRLYAGRTVLVQMDANTLFYYPGRLLHQEKGKWTIKMWRGIKHENANKVLENISVKRLVDGLYGDHEGRRSIRLGRFIRTHEERDPADIASDWQVYQYNTEVDRALYKHKAMLQKILHHTINSEFSALSVSSVPALALYLNEGNPGYAIFRNHQYMTAVTLFRRPCPAYFTGGITTDDQARILNWLHINVQSFLSAPPKDFELCIAHARTLFLAHCHRETFLGCIEAGLSELEREQSVLHQAWQRLVDFSGKTVDGKMKRLKADVDREALQILEKVMFDRSQKAGVAGSEQWGLDVGPPEDLWWPYDGPEKNDPDLHVATESDLEESEICKAEREKMEQKVREKEAEKQNHAPPRPKPRPLTKEQAAERSKKALQEAGLTAERPDLAKEKVVKTLQTVQENAQLRRSKRVADQTKETEETENNKKSKKQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G140</accession>
    <name>A0A8H5G140_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G140"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5356371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="740" mass="81292" checksum="A1F15B034A1ECCF3" modified="2022-01-19" version="1">MVKVAIKLLRVLSSNGYDEVKARKRLNREVYVWHRLEHPNIVTFLGTSYHMSGRPALVLPWFSNGCAPEYLRRNPHVDRLQLILDVARGLHYLHTKKPSIVHGDLKGNNILITDDGRATLSDFGLAQVIEQICLPQCPEYTPSGGVGPIRWQAPEFLQDDTGHPKMPGDIWSFGCTCYEYISGRFSTGYRATIGADFITKVLPHPSKEGETVTLQIWDTAGQERFSSLSSAFFRGADAAVLMFDVNSHETMEALTKWWDQFKNHAPLSDDEMGDFCCVVVGNKLDLLQKDGHNHVGNGSAIRLAGHLNGTKKKAVSREEAESFLKELVPPEFVKPVSVPEVEMVSEEEEIQIAEELEVVSEDDEDPLSASQATIRPHSPEISLHFPSVNGRDSSSDQSTSIAINGRPLSPLDTRTRTNSSSNNSPSSPSFIRHLHRHKSQSKSRSRSANSRYYSGVSSSGFSIYHTPSSSVYDQFDSARSSPEPWEPSPSSGSPLSSSYTPVSLLRSPSPASMNNAHRAPRRRLLSAGNKSILSIDSMKTRSTSSVATVTPSFYARGNEDPDDDWDQDNQGTVGSSAGSFFSALSRSFSSASIAPALLSEHDSNSTSGGANDPKLGKFKHSPLRLQVQANHFVPPPPNPPKPSSPEPPDCGPRLFLTSAKTGEGVKDVFEYIAKRVIARWEWEERVEAGRLEFREGEGGDGTWLRSWGRRNGVGKGIKLDARTSGTGRGRNGSANWNSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G606</accession>
    <name>A0A8H5G606_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_008562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G606"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="725"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5358825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="966" mass="107731" checksum="F9DE78559A330B09" modified="2022-01-19" version="1">MIVDEETPLLNKRKPKRTPLPWFQVTIVLFLQLAEPLTSQVIYPFTPQLIRDIGVTNGDETKVGYYVGLMQSLFFFTQALTVMHWSRISDKIGRKPVILTGLFGLSLSMYCFGLSKTFWGLVLRNTRAKFANTIPGSRSLNGALNGNIGVIKSIMAEMTDSTNISLFIRALEFLKKYPYFLPCAVPATFSAVAWIVTFMFLKETVRSPISLSQLFKFRKSKANVTLQTVAASQEPATTTEPANSNDLTKTATIPDDEKPVPLRQLFVPRVFIAAGNYACLSLVDIAYRAIQPLYFSTPVPLGGLGLPPSRIGNILSVFGLLNGVIQIFYFAKFHDRWGSKITYMVGIASTVPIFLTFPILTYLVKTTGEVTTLAWVVVALQILFSILISFSYGAVFIYIQAASPNRASLGATNGLSQMSVSICRAIGPAAANSLYSLSMKHQYLDGYLVYVVLLGTSALALITATLLPRRLQICSPLLCTATRQQEPNKVPPLSTMSESFAAILAMSKAQTEEKQAAVKAMAEERKRKELEQKKRQLEHDKKLREEEARLRKKHFEDQKKEVERQRQREEKTKALEAERQKKQEEQRNALLYGPKKASRYPSSASQDRTREEVRRKRLPSEESDDDAPKGVVMTRQEIRERKLQQQLKREFGSTKRTTPSGGYHRRGRRLPGGAVDVTTAGHPQSSSGSGSVRERLAAMPNTLQPLNQNKRDTRTIDEIVTDLHARGGKKKTIEGEQAKEFDDWFGTKKKEQPTSRVGSTSAPASGSNTPTRSSQSYGSYVHGPSSSSSAQRPSTMIKPIPKLTPSAKASGARPSSVEKIRPDKVPTSKVKAKSSISRPSSAGPSTSRVPSKRPRSPSRSESPYSKRRSYEDYDSEDLDDDDEMDDGRGGSGMSSLIWQIMGKDRSRYVNMDVLSDDEDMEADASAVLREEQRSSRIGKREDAIALAEEKRREEEKRLRKKERERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB76</accession>
    <name>A0A8H5GB76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_007293</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB76"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034252974" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5361708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="436" mass="47718" checksum="89FE41B3226BEDA4" modified="2022-01-19" version="1">MKPFSLLPALGACSLLTNAVFAWEKSANGTCTLIPHGSGRDDSQQFQEVINATECTTIVLPQPYTYSIQQRLYTDITNKNLHVYGRLLFSDDLEYWINNSWMTDFQNLLTAWILTGSNWTLSGGGFAQGGIDGNGQPWYTRAAGVVNQPGRPMSLYIFNASDSLVKDFSVVQPQFWAFFVSQSHNITLDGVLVNATNHDPAAPVPDPNAVSHGYSWVINTDGIDTYRSDSINIQNWVVQNGEDCVSFKGNSTNINVRNITCIGSRGFAVGSVGQYPDRFDNIINVSVKDVTMHPTPNVSLTGVVYFKNWIGEEIGTPPNGGGGGSGHVSNLTFENFAFQEADQPVYIQTCLTYSDIDTTNLCNTSKVLMEDVTFINFQGNSSGTYNGTLVDLNCSSSTPCRNFNFIDWSVTAPEQFEPVYDCINAENITGITCGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH69</accession>
    <name>A0A8H5GH69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH69"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="85"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="26781" checksum="31BE86F12FE206AA" modified="2022-01-19" version="1">MVDRKGLVLGMQCDSQLGAVFMDSYLLHQLILNKDDDIIFDCSDTFFSASRTRTSSVILFVSLYAPTLSSIIRVRASLSDLVSTVKVELQVLKKLFGENALIKDQEEAKPDPIILHNHTWLHFACHGFLNVTHPLKSFFKLSSRNLTLKEIVNDGCISQRGELAFLATCHSAANEMDGAPDEVISLTGVMMQGSLRFYGHLLEKGVGNADVKLSAMALHLATNAMREGIPAERWCTFIHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHI8</accession>
    <name>A0A8H5GHI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHI8"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="271"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5364901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="612" mass="68322" checksum="0DA093B9053BB9D5" modified="2022-01-19" version="1">MYYISHSRTHIRSQIRRAEICPFSATVGLEAIQTIVKRCTTWMEGLYPWQLPLIAGTLDGDDYLCITATGDGKSALFAIPIIILLEYNRNPELYPQGLRTRANPLSVVITPTKGLASSFVHQLKRDFGLSVLSYASETIGAAQCEGKNLVSMIKECKEWQVICVDPEHLTGRDWRNITDSNTFVKNLVSGTVDETHLILEWGRDFRTAYCLIGKFMRGRFPSHASISGLTATLLPGPSTTDVCRSLGLYRDQFTLVRHSNERKKHATRNSPSYQGIVWILIPRSSSISQSKSEDIYLLRCLEHSPHGFSIIRPYHALLAAKFNQETIAVMENDPRFMIIVSTVALSLGINVKTVVDNIGIDIPKTPEGWVQEKGRASRNQSLLARGISFISKNTIAAARKVVANPSTQPDIHTPSRLGPGRRNNAGGMDIHRAQLIVDSCTESACLTARQNIVFQNPPLDISQLDCIMAQRKVYCFNCAKRAGVTYTFPPSPQPAGSPSLPLFINPEEASKRKKLSKANAARLHEELVIFAKHVCVMERDKSCFWYLPDDAHFPAELIQEIIDNFLIICSASGSLQPYIKSWLHAATYSSKLIDIILKFYITIGSEKKKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHS7</accession>
    <name>A0A8H5GHS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHS7"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034558278" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="264" mass="28027" checksum="8167E6DBF2FA6DF7" modified="2022-01-19" version="1">MTLSFRALSNALILLTTLCSLSAVTEAANAKRGIAYALDLAQNGDAGKVANTQISWAYDWQAFAIDSLPAGIELVPMQHDANGINDFQNTVKNLGAKVALGFNEPDVAAQAHLEPADAANLWKQGIQPLAGAGVRLGSPAVSSSPAPAGTAWLQAFLSACDGCTVDFIAIHWYGDGADNFIAYVQDVHNQFPNKNIWVTEFASTSTDPAAVQAFLDQTINWLDGQAFVERYSWFVYGRSATNGLISNLLDGSGNLNALGNAYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIX7</accession>
    <name>A0A8H5GIX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIX7"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="227"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="507" mass="55749" checksum="A423990585D1CB13" modified="2022-01-19" version="1">MNVSKLPAHPSLPEIENIILKEKRGNCVPVYVQLPADLITPCMAYLRIAKDSRYSFLLESVIGGENVARYSFIGADPYKIIKTGPGEEHTGDPMTVLQKELSLHQYVQIPGVPTFTGGAIGYVAYDCIQHFEPKTACELEDPLGIPEAIFMLVDTLLVYDHIFQTLKVVSHVFSPPNAGPENLAFVYQTAVAKARRLAKALLVSTTPEPPQPPISMGVEAVSNVGKTGYEGFVTTLKQHIVAGDIIQAVPSQRLARPTSLHPFNAYRHLRQVNPSPYMFYLDCGDVQFVGASPETLCKVEKNLVFNHAIAGTTKRGKTPEEDEKLGAALLASEKDRAEHIMLVDLARNDVNRVCDPKTVKVDHLMKLEKFSHVIHITSQVSGQLREGLSRFDAFRSIFPAGTVSGAPKIKAIEIVSSLEKERRGVYAGAVGHFDFANDSMDTCIAIRTMTFKDGVVYLQAGGGIVFDSVEEDEYIETINKLGGNVRALEAAEQHWFDIQNNAKRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIY2</accession>
    <name>A0A8H5GIY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIY2"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26818" checksum="B5E8289E1CE210F6" modified="2022-01-19" version="1">MISWHHYDAFANSLREIDKKEDVLVTVWQATGPWFSAGTDVKNRPTGSRVTLRDGFLNGASRTMTDCGHALYTHSKILVCALNGPVMGISAAFLGYFDFIYCMPNCWLALPFPFLGISLEGGASVSFVNRMGLARANEVLIWGKKKTAEELLACGFVNEILPQQSVEAFHDAVRAKLLDNLEGLDPAALLSAKKLVRAGLYEKNDPNAVNLRESYAQAERFVSGVPDVRFGRIARREIRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ52</accession>
    <name>A0A8H5GJ52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="55"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
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        <location>
            <begin position="120"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="387"/>
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            <begin position="465"/>
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            <begin position="643"/>
            <end position="652"/>
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        <location>
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            <begin position="752"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
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        </location>
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        <location>
            <begin position="797"/>
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        </location>
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        <location>
            <begin position="1029"/>
            <end position="1041"/>
        </location>
    </feature>
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            <begin position="1301"/>
            <end position="1318"/>
        </location>
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        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
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            <begin position="1393"/>
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        <location>
            <begin position="1406"/>
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    </feature>
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            <begin position="1473"/>
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    </feature>
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        <location>
            <begin position="1511"/>
            <end position="1533"/>
        </location>
    </feature>
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        <location>
            <begin position="1607"/>
            <end position="1640"/>
        </location>
    </feature>
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        <location>
            <begin position="1655"/>
            <end position="1668"/>
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    </feature>
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        <location>
            <begin position="1689"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1822" mass="194692" checksum="F4A36BA699B6E7B3" modified="2022-01-19" version="1">MEEPINVPPQLPARSPLRPTAKPIPISLDTLVETTMEEQPSSSTSSFGQQTPLTKREHALLELLSSERAYASDLALVRDVYIPMALGEQPSFHSGSLTSSSSSSSRTLSTISSDASSSSQRNPTTTSDPPMTPQDVKIIFSNIAELAAFSDMFCDGLEQALGDTLTPGKGDDWVGALFLRIVPSLQPPYTYYITHHHTSSTHLASLSNPSKSSSTTTSSSANNPNNPNTPNTSNNATNSNTNPSLQRYFEQTRALASSVSHAWDLHSLLIKPVQRLLKYPLLLQAILDETPGFGEDSKTNGKATGKATEAHPDLQNLILAKAAVEQVAREVNEERRRREIIRAVLNGELKMNKVVPPTVGVSAQMSAGIGSVGSGIGWIGRVRGKGRGKEGKEDKKEKEKDGKAKGKDRDAKGKVDEKDKEETPFTSPAPSAMSTSTPSTSTPTTPSASPHAQSFPGMVHTIHMSTSPSLSSSSSLSAPLSSPSPLSSTFPSALTPSTSTSSTLTTTTLTPSLSSTVSPSLALAPSTSSTSTLYPSISSTSTTVGPQIQQTQIPLPILISHLLHLSTYSESLARALTTYTKSVEDMIRALIVWSCRFARVIGIEVANPVLNRPQLLPLSPGEGVNGNGVNGHGDTHGYDGYDGEGQGQGQGQGSEAFDAYLAVLRGGSRVSQSQVSPQSQSQSQVPGQAQAQKPRLRHRHTNSFSSVSTSASAPASGTGAGSSTYAQLHPQLQPQPQAQASRSYTHLQCHDNNNNNTNTNTNAQEMRYSDPNPSLSSMSMSMSMSNSNSNLPDPSNTHTTQPNSHSQGSEPPSLLTLSHILTQTISSTLTDLSLLNSTLKAPLKLVKSMEEMEPWHEYLVNMNYGGGGKNKAGGFGLGFGFGIDLDGHGHGGVGAGVGGVGVSPGMSGFSVLPGGSSATGTGSGLGLGSSSGSNKPHIHPSLISASSHYLALRTQLSRELPIYLALWDKAMVGIVLRLSKAQERFWWGCKERWGELWECLRVEGEELGGGGGGGGWGVPSEVRDQVQGQGQGQGQRQGQGQGQDADTPMAKTNGEQLGSSQPQPQPQPQPQPQSDLITEEEIETIRVWRSRWSDVDEVLGGLGICRDYKSQLKGLRRSAGSGSGGGNGVGGVEVMRVPLDSSGVSGASGYGYGYGYGGEDEYAYYGNTYGIGIGQERGYGWGEAVPAPAPGPANANPSRELIYNEEIERRMQVMQIMEMERVQRERGERERERERERERERERERREAASVAFGVAPSSGPGSWAGKRDKEREREQEREREKVTLGKKNKDNKSSTKVDTKTNGYGSPNGKQRSPIASNVTNMLASLDPVAKHTQSQAQATPIYTQYSMHGSQREMSPISPISMSPSSHGSNESKSMFGFGGRASRERDHLGSSPTSNIKMRSTSKHREREKERERERDMKVKYPGPDATVEEWEEFMLLQQQYGLGAGLGVVGGVIGFTGGMGGMSIPRNGSGKDKDKDKDKEPRGHGLSKVKSMPGIDANARTKLKPPSSLKTATSGSSLSGSISTSLGLGAPPPYSFGSGSGDAEEYGVGENLEQTENGAMLTVKEEDLTPTPKANPSEGGLGADLVTTRGRDSTTRKPSFRRKISDTLRSKSVTRAEKDGEGERPKEKEKEREKRPSSSRGAAMAREKLLSPSSTNRSRMSEPNPSLMDGMEGPSPATRTMSSRSANFGSTSTSNSNSASSSSHTSSSYPSSSTSMSASAPFIPTKPRRDSWSSTRPKYTCIVVHPCKPPQAVSYFSFPFFSLVVGDYYQVLQEAGHPSVHPKLPLYVDDGEDCLLLCKDQRGVVGWALASFLQPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJX1</accession>
    <name>A0A8H5GJX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJX1"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33649" checksum="77FE0B55585BFFCB" modified="2022-01-19" version="1">MDGIGCTSGFCCPVCASGYLYSGRFLIVQRICMDIWAPAIFHFAIVHVEFLGISKLLLPLHPDPSQHLNFLVDIIKTISVSAQPPLRLRFSVSLRPRYLNYLVSCTSLLTFLFEVTALIIELYPSRMSAPGMSADSTAVTTPPLLDPLQKRARPRRLVNACTIEVEEFPSDDSVSPYDILSHCWKQGQEVSYQEMVKCQSSIAAWLSIRAQSGYKKIVAACRQAREDNHTYIWIDTCCIDKGDHGQQSQDINSMFDYYKNAKVCYVYLNDYDSCQFDLCNMYKLGSPPPPLPSRYPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLP4</accession>
    <name>A0A8H5GLP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003737</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLP4"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="110"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="451"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5367368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="608" mass="65628" checksum="A2A8887589B55078" modified="2022-01-19" version="1">MYQPNQPPQPGEALARFDSNLSAMTNDSRTYLVNHPGISSREKHLPLYHKPRHAHGSPHDGSGSRAHSWMKLSWEELLKGWRLLLLGSWLNILLLVVPVAVRLGYRVRAICLIALIPLVKMHEVSTHELAIRIGGSKAGLVNASLSNTVEIVVAFSALRKCELEVVQSSLIGSILGKLLLILGLCFFAGGLRFSEQGFDATASQIHSSLLSISVTALLLPAAYHFAVSGDSDVMTPRQRDGIMDMSHGVSIILMFIYLSYLLFQLVSHTHLYQDLQDKSRRLSLKVAPIFHLDKGKTLTPSPSCQSDGSDRENISKWSTDVRSAISPSSSNEYLSRSPSLSPRGRNRALVPGTAYISQDQPGFSTASEITLAEPVGVYPPPGGATVRLVDVRGGRSFSGSTINSQHPPDLIEIPLDSQSKAPLHYPSPASSEGSEPKVQGPQLSIFLTVMSLAFVTIAVAFTADWLVEAMNGISSTISKQWIAFILLPAVSSIAECGNAIGGSVKDQLTFSISVAVGASIQTALFVIPLMVTLAWSMGKPLALLFDPFESLVLYMSVQTMTHVMGDGKSNYMEGLILICLYIIIAVSFWFYPGSSLPASLGAACSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM88</accession>
    <name>A0A8H5GM88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM88"/>
    <dbReference type="OrthoDB" id="3265199at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="38471" checksum="793C7574EFB51595" modified="2022-01-19" version="1">MPRTRRQTAQIPQEPESSESPEPESSPSSQAESSGDEGSGTEDEHTSADEADLDGDSQLEDIGTNSKAGNRQSSNWLPWQDRALIQQVNKVRPFEAKGKSGQKWEEVSHDLLQSQSEDGTKKTPIQRSGESCKRRFNRLIEAHQRGESESLQKTGTNEEVTGHVQLMAEIYSLFIENQSNVKSLSAKAQQKVQNEANAGLELREASMKGMVPREGLTDVAVGNATVRERQGQRRRRVESDSDSDSNNKENLEPKRKRVRTSVATSVKDAIQQHLDNNDSAVQEAQERELKRQEQTKALLTKVVESNDKVAESVSQLVNAVNTMVDTQQKENANGQSKLLDALLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMZ1</accession>
    <name>A0A8H5GMZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMZ1"/>
    <dbReference type="OrthoDB" id="2752996at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="60"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5367996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="34989" checksum="793C7C53CB10CDC4" modified="2022-01-19" version="1">MEQPEDYEKGPDDNVREEDTEVFDYRISITGNLSDFFRIFTDEVDTSDEVLIHKVNHGNEEMEITVATDGSCTSNGQEDAKAGAGVFYGHRDPANQSIRLPKQVGNVRIIQSNQAAELVAAMQVTKPVSKTAHVNLETDSRYVISHLTKGLRKMEDTGYIDVNNAKIIRAMIARHRLHEAPIHVKWVKGHSGHEGNEEADTLSGMAATKTTEDEIDLDVPPKLRITGAKLKVLMQKLTYMAIRQHKSAVMPDRPQTCNIITQVKMQAQSLFDISPTDSAIWASIRSNTLFLVDGCQQCLHDWYALATYELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN34</accession>
    <name>A0A8H5GN34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN34"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5367963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="548" mass="59984" checksum="20B8BDA25C6EFABB" modified="2022-01-19" version="1">MCSDSSSPAIYDLVGLGFGPSNIAVAGAIVERWGSDLKNNESSSKNLLFLEKNTSFQWHPGMLLPGAQMQISFMKDLATLRSPQSPLTFLNYLHSQNRLSAFINRGSTTPSRKEFADYLGWAARYVEQQGVAVHYGQEVVGVDEDSDGLILVTSRNVETGKEHVYKARNLIVSPGGSARIPNVVAPLLREQSVIDRSTVMHSSRYRICRDKLFQSISSPSSPQPLRIAVIGGGQSAAEVAINLRDCLSLIPTGNSPTGHQVDMIIRKGSLKPSDDTPFSNEIFDPEVTETWFGSTQSGRERVKAEYNSTNYSVVNPRTIEQLYEIIYDQKVDSAIAARRQDKSTPSPVINICANSSIISINHNSESNAFSFTIVNSHTREVIESKYDAIVCATGYIRTNWVDLLRQSKQLGKRFGVDSSSRVPVRLVPFAPRIASDVTSITMPELSPTISETSSGLHSPLTPITSSQPATPTVEGNVDQAEQKVYISRQYRLLPLSSASSSGKTADEELKAKIYVQGMEESTHGLSDTLLSVMGPRAGEVVEDLFQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPR3</accession>
    <name>A0A8H5GPR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPR3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5368833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="498" mass="54715" checksum="9C2D21C079D17B9C" modified="2022-01-19" version="1">MSSENRFKASEKSSEKDFSAEDVKVEVAVDRPAESSDAWFREERKLVRKLDGRILPLACLLYLFAYLDRSNLGNARNQGLPDDVLGGDETGVLFDWVNSVFFFSYVLCQVPATIVSKLVAPRIWLAGAAIGWGICSTLMSTTFDFGGIMTTRVFLGIFEAGFGPAIPLYFSLFYTKQEMGLRMAYWFGFAAVAGAFGGIIAFGIQHADIDIERWRLLFIVEGIPAVILGVVSYFLLPDRPESTSFFTERERQIVLERMNRATSGDIGATVNKAHIYMAFKDWRIYTGGIIYFGLNAALASTSAFLPTILKDTLGYSDANSQLLTVPPYAVAAVVLTLFSMFSDRYQTRGIPIAIASSIGAIGYLLNLVSNNGHVRYFGVFCITSGTYTGIGLIIAWFAHNLGSETKKATGIPMFMAIGQCGSVTGSHLFPKTDGPRYMKGFGVVCGLEFLGAICALIMSASYRWDNARRDRDEGVPTADTKVNVSELADRAPNFRYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS20</accession>
    <name>A0A8H5GS20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS20"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="483" mass="53302" checksum="B2CE52CC7CF6D611" modified="2022-01-19" version="1">MFANTKNLWRRSIRMKESPVTSSDSKAPGESGGLASPVTLAVIGCGQRGKAYARYALQSPEACKVVAIAEPRPQTRSRFAAQHKVDQTLVFSDWKELHAASAETIDAIGKRLADAVLIAVQDHMHVEVALAFAEQGYHILCEKPMATTLADCIRMEQAVKKAGIIFGMGHVMRYSPYSQEITSIVKSGALGRLINVQQLEPVGHFHFAHSYRQLGEGEPEFIFLDDKELPKLTFSSDIDIICHWMGSPVFRASSFGSLQHFRKSAKPGEAGAATRCFDCKIEKECPYSAKRIYLDRVSSGDIGWPVSPLVDDIPDIENITAALKAGPYGRCVYECDNDVCDNQVVNLEFENGSTASFTMVAFTSAICDRQLRMHFSHGEIIGDMSTFTVTDFRNNKTKTHYPKSEGGGHGGGDMGLIRTFVEAVRTGNQKLLGTDVEEVLKSHMTVFAAETSRTQQKVVDCNDFELRAREMVQGTLSHVLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT70</accession>
    <name>A0A8H5GT70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT70"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="352"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="578" mass="64206" checksum="8ACFB6233D27E5F0" modified="2022-01-19" version="1">MSRAGPLDLNDLIPTSMFPFRGVKYHLAECLPPESTSSLTHILNTNGATCAESLQDATHVITNSNCFEGYKEVSDSTAVVTEKMGGTIHSPLTSTYSPDPSMLFSGVVGCATELRDADMQIISAGITALGGQWRSALSKDVTHLFAISSSGDKYRNATTAQEQTKIKIVLPHWFDDSVRLGLNNLETEPYEWPDPPMLEAMSKASSGPAKKSRKLSPERQALLKTALWDPEKEIPTRFDDRDIFGGRRVLLGLSLELGHRRGAVEAGIERTGGIVVDLEESDTVQEIDKINECDKIDECDIFVTRYRSGKAYYKAVRAGKTIGSLAWLFHVQSVGVLKRPLDQLLHYPIPRHPPDGFSDIEITVSNYTGENREYLKKIIETMGAKFTPSMSKRNKALIAAHNDGQKAQQAVAWYIPVVNHLWLEDCFIKWHFIEPSSQAKYTDLNVVSDFSVYLGNRGVGSQIEDLEEIIRQEAEEEESERQAKALSATQHSVRDVTEVARELVEADGWDEDDAAMDVDERRPGSSSANRKAPSLTSLHLTSQPEISEILVPKPFRVLPDEAAGRLKQALASPWLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTX5</accession>
    <name>A0A8H5GTX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTX5"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5370785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42254" checksum="1CA1DD81262DFDE6" modified="2022-01-19" version="1">MDAKLHKTLTSQFGPPSELIDVGKFVKDVADTIEPTVDPVMSTEDYRVDEITEALSNVWNDPELSAYLCRTQDKSLALIHAATKSGRSRIPKLSEPSANQNTVNELQSKLDEIKLSSWKLSSDAAIFTRPPRTSDRNTLVQIRKSDDTDITDISNEPQAVIIFSVHIPLSWRQSLLTRSSTHAILSSQTLEDLFKVIPCDYDALPEEYITEDGNVGYTVDAPKKDSSGYVICIDEVGYGDGGENDYADKLQQHLKTTNSTLQLRKADTPASATPLSSLSLRINQPYWMLHQGNCEHFIVVEHIRMKDASDPATGFPLTLQITPPQLDMCRACTKTPAIYAITGDIRLGESPCLLCGTCWNVMGSPIEDGVTVISCIKRVGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU13</accession>
    <name>A0A8H5GU13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU13"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="64189" checksum="C7992CBAF5306C1F" modified="2022-01-19" version="1">MSTQSFDYVIVGGGTAGLVTASRLSEDPNVTVAVVEAGGDVAHWPDTLIPGFFTKNLTKPEIDWTFFSTPQTNVNNRSIYLPRGKGLGGSSVLNFMTLGRASKSEYDAMESLGGSGWNWSNYLKYFRKSETFSADPASAAKHAFKPDPEAYGTEGPLHRILPSWISEHHMPYYEAMKSLGVSHQYDSSNGNCAGTGTGTGAIDPKTATRSSSVSAYYEPVKDRPNLTAIKLAQVTKVLFSKGSSGKLVATGVEYVQDAITKTVEAKKEVIVSAGTYQTPQLLELSGIGDPKILQAHDIPVLQDLPGVGANCQDHLSTAFVAEMNPEYESMDVLANDPVRAGAEWQLYETKKEGIFSAVSSIAYAFLPTKFFADVEAIKKAAEDPTIDREADGLAGMTKTIRLEKEWLSHDEVPQLEIVQVPAFVPTAGHVPEPGKRYFSIFMALMHPLARGTVHISSADPLKPPAIDGSFLDNKVDRALLVSALRFSRKVIKTEVLKDYLLKEVIPGEKMQSDEELEEYIKNTVATVFHPVGTASMFPQEEGGVVDSKCTVYGTENLRVIDASIIPVQIGAHIQATVYALAERAADIIKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUY3</accession>
    <name>A0A8H5GUY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUY3"/>
    <dbReference type="OrthoDB" id="3129614at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="438" mass="50366" checksum="65006A979BEC182C" modified="2022-01-19" version="1">MLESYTGTPWSSKLPVLHDKLSSLLVYDEFQGFQLIHKSLDDFLTDHQRCGDDWFLDHHEIYKNLTSACSKLLMFYLGNACMSNSVSSEKRAIQYASFLWGNYHRIALQTGSQDNNVDIEAEVSHFLQQYLLQWVFYAVAGSYDDRYYTVLFLSEGLIHLSENLDKTRDDPFAQLIHEAHRLSSALCANNYHQVQKANTILYFFHFLCAAYRKDVKILHWWYMPVFVQMAGGSRNYGDIIEAIKELNDYPLLLSEEATLAENIEIFGVPEVIDDKMLAKVDWDLKKSLDDYLWMGVSPISLRILKPIPNAGATTMTLAEPSTLPETSPNDSSQTLPNANPNTIQGTVKEDIANQLCQLQRNTTMELGKLRRSNGTLATHTQYLLYYDQDHNCEFEEKEKGETEVGKSPSEYIWKLQDLYIGLYRAYSLVRCYRLVPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY36</accession>
    <name>A0A8H5GY36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY36"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034324205" evidence="2">
        <location>
            <begin position="33"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="589" mass="64390" checksum="96FF0D18B2870FDB" modified="2022-01-19" version="1">MIFQCHLRFPFARTLMAHHLALLRAMLQNLWGRIMALKYLPLELSPPWTFERNSYFRRLSTIPLATINTLPTPLLNLVDTARSILFAVCQIYQTLEHYTLHSIDDRLSSVLKKVLHPASTDMIQFINSLDRFDAMSRKMVPPPAVCRGVVESCRDTVAVFGKTVGVLALQLKVIVNVDDSRYVRSLLVQLYGAAAEIALAWQSMIPQVDQIKPFLHSKSVPSPPSAMGSESHHLNSSYSSLPDSFPSPQPRSGTSVRSHNSRRHAGSFSSRDVELGKALPEEAGAKHTTTSRGTLRAAKRQANLVPAALTVQSPSPTSPGIQSSLPSASSSVVSLAESSRVNHSRSGSLSSLQASSTSSSPSIPAKTPFLDLPSTSRNQVDKEALQAVQAAVDVAPTVWDQMEDALVDALESNAEVRESLDRARWVTQRLSDMITAMKEGDPAGDKKTLREDANVFLKTVVQLSNYVKMYGGVRSTALRTNMVKLTNSTEEFAILLHVSSFSPSTSAPRPYSPMLSASSSQVSLLNLPEETRLGPGLSRSRSAQPYVSKIPVSPGVEGSRSALPSQSFKLPIIKRLRDKDHRFDLNDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ46</accession>
    <name>A0A8H5GZ46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ46"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="439" mass="48125" checksum="7D7522FC369D5523" modified="2022-01-19" version="1">MVNRPHPSTQLSVGVAAPPYDVSYEAGQSQDAQGLQGHYLVRHPNVTGLQQHQPPQPPVRGHHLPSSYFGLANPTGVQTFSGLTDMETRMMGDAPTLAQSLGHPHVSSSAVINILMLDEPPYLPPPKPRRNKLKEATLKVTDDSLPTGKDQPPTQSKTKKPRKSKKTTQDPLPAGGNQQPPKTKKPRAKKSAPKPTPQTSTIAIDPMPKESVPHEFTVPVAPLGHSRFVMNFRDPDHIRDHKDIKDEHNAGRRYAERKDKGQKRKREQHEEHLTDSDCVSVKRARLPNAWEDVTTEESQSHAHPSSESVAPIVGPSRYVVDEHAPAPRAPTLQMVSATMHHVVPERVDGEEDNPPVSPTIPSYENAIREGFLFSYPPQRVQRAYDPDFSLEEDLPSTAANPSGSSGPTSSTVSSITPMDNSFTPLDLGVVNSKIAILCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ77</accession>
    <name>A0A8H5GZ77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ77"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="455"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="547" mass="59331" checksum="0F387A72DC5D3B16" modified="2022-01-19" version="1">MTERSKLDADQFEYPPLLMSTSVQSRVKAFESLAGSSAPSQMHDLLDHSAQNLPYAPRQRKSPSPSPPTLGLKTSLIDLKDWVVDDGSPPRTNGFHAKKTPTKTTFIPPLINLDPDSPPKTPKAPPLPPRKPSTGNLRSFSSSSLPIAKHSAPPIATRRSDSLTVEHTYPPPPKLEPNRSRHAPASSVSSFQSVSLSSDTDPGTPGSVSSNFIATYPIDHDDDAISLDESFENVSTTSLGSPTTTILNNDWSKPSLPPRPSASTSTSSSSGRRPPPPPPPSSYAERSSASDRSSLLSNKSTLSSASNTTATSFTSASTHNPSIRSLKSPPLLPLKNPTLSPLPNLTVNSLPTTRPTPIPSAVRPRYEQLFNGIVVQKRKAQLLRNREWEKAGRPSLLSPGPLSPRRTRPGWRGLSIDLITGGDDLLNTSDSTGQRGIETNEELDVDTHVGPTERLEGYIVRIVWSRSKLPKEKLGAIWSECDPSTKGSLDRDSFCKGMWRIDEELRKSQMGIGRVPSSPATSISSITSSWTTVGRTPIQMRSRDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZI6</accession>
    <name>A0A8H5GZI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZI6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="21703" checksum="A200E42AD45F3F4E" modified="2022-01-19" version="1">MPPSCLSKAPIRSLSCLACGQFFKEDEGHLLQQHLTAHDSDRILFLRCFHTVTQIKRSKEGFPCPVGHPGGCGFIGTVSALLEHLTYRADQKYLAFFFNGPRPSTVSHGNPSEHAVTSPASCTSHDTVSAPPLSRERKASLGRKLDFYEPKYPMIGYPLSRDINEMAASIKMKLNGYSQASTTQVNYRQDSRVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H090</accession>
    <name>A0A8H5H090_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H090"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="595" mass="66411" checksum="465672B0A4D3598F" modified="2022-01-19" version="1">MTFDPMDSVTSRLKGQRSFTSQRNLLPAIRPDIPLAQYTQQPAYSLIAWTFGRGSVIWKIWPAVLLHTLFAAGVVSLVEKGHFTHLGIPNVMLTVLGVVIGFVISYRAMSGYDRYWMGRTAWSDIIRNSRTMGRLIWFHVPPRLTPKTPEEAASNQILRSVGEMSKVMAEKRMALDLVEGFAVALKHHIRGETGIYYEDLYDLVRPLHDHDHTLEQKAAAAMTSALAPPSRPHRIASNPSLPRARNSPTPAMTPSEYPNPHPKGKSSKNSLGSNSGSVHYGDPGFNAYGTFPQTTSPRGSIRAARRSNSSLSSHSDGSAHSRHQDLAPSRNPNPPAQDVMGQVDGNLIPFAGAFSSIKRLFTRKRKDGYETLPTNAWADSESNQRKWGAPVQPRIGSRKHTLVSMDERDKRGENLPLEILRCLSEWSSVLEDRNTTASVGSIIGTIAAMEETLSALERILTTPLPFVYSVHIRHTVWIYLFFLPFQLVRDFGWYTIPGVTIAAFIYLGFLAAGEEIEQPFGYDENDLDLDMFCQEIIHVDIENLKKSPCLNAYLPTKQQHKLVRHKSLTLTEATAYESYGNGNGYRHEVDGSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1B7</accession>
    <name>A0A8H5H1B7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">D9758_000328</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1B7"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="304"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="377"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="502"/>
            <end position="506"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF5374876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="549" mass="59253" checksum="9B6204667A4CD52A" modified="2022-01-19" version="1">MSLSIDAIKVGSEKHPKPADIHFQYGTAGFRTLGGVLDSVLFRVGILAALRSKRLDGRTIGVMVTASHNPEPDNGVKLVDPRGEMLEASWEVHATTLSNAPTTDALIEALNSLIQTAKIDLSKPARVVYARDTRPSGPALVAALEDGFKAIGAEARDAGVTTTPILHYFVRAINTKGTQYSYGEDSEDGYFRKLSDAYKKLVTGRPPASPLLIDCANGVGAIAAKKLANYLGDSLPFTLENTAITTEGALNNACGADFVKTSQKLPPSLSNVMKPGQRACSLDGDADRLIYFYLDERGVFHMLDGDKIAALVAAFIVEQVKIADLEDKVKVGVVQTAYANGASTKYLQERLPVKCVPTGVKHLHHAAERYDVGVYFEANGHGTVLFSDDTLATLHEHQPSTPAQSRGLENLISLTNVINQTVGDALSDMLLVEVVLSHKSYSGVEWDSLYVDLPNRLVKVVVADRNAFKTEDAERRLVSPPGLQSKIDDLVNKHQGGRSFVRPSGTEDVVRVYAEANLKAQADELAFRVAGLVYDEAGGDPVSRPKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGS7</accession>
    <name>A0A8H5LGS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGS7"/>
    <dbReference type="OrthoDB" id="3221235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65598" checksum="2416FBC65CEE7F5F" modified="2022-01-19" version="1">MTITTSPFSHLFCSNYAASHNDVPLIKDLLSTSLETLCRLNSEIQQLQTTLQKLEQERDSVQHYVDAHKALLSPVRALPVEIISEIFAHCLPGDRNPICSHAEAPLLLGRVCKDWRDVSLSSPCLWASIHIVIPMSGNPSVLHPLIDARTQGIESWLTRSGSLPLSISIFAVPSEIRGEVTGGLILDSVGNLLDCISQRSNRWQDIHFNLSRACISMVKERWPWGGNRELPHLRTFKLTRPTRPLRSPSAKFEREWVSKAPNLRILSLRLVEIGDLLVERFPWSRLTHLELQMPTIVLSAAVHVLSQCRDLQSLTMSSVDPADAPTEVHTITFPYLRSLSIRSRVCFADKTTAVDVCNIFCYIDAPVLRSLKVHIWGSEPDSCIPFVGLLSPGNLIEELDICGPSDILIDTLALLPNVTVLRIRNSTLYDILLHRLTPSHSIHDEEHLQPLCRSLKQLYLIGSSVKNNDQMFLDLVYSRRNFILVPDATDSMPLDPVTARLDVFHVLLNRYKQSIDLQDQLQKLRDQGMDVIFAHREEINGNLNPGRGQDADDCFSQPTISHSGYCGRIGNEERRHSWWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHS0</accession>
    <name>A0A8H5LHS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHS0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="14856" checksum="337C9C826B8584F0" modified="2022-01-19" version="1">MSGSKSSETSKQSKPESKGHFCPCGEQILFLKYDALSDPPEELLNTNEPLLDSLYAQEARHDIRAAKEMKKILAAHRERLYNWTSILLDEEYQHLHQLAQEFHLSHEKRTLRDHSQRSLMSIWIHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLF8</accession>
    <name>A0A8H5LLF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLF8"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61101" checksum="A1DDB154DF3D8FED" modified="2022-01-19" version="1">MSLDVGWGRSRRFGCSSAHSSIGPMPRTVRVAVIGSGLAGLTAAYLLSNSSNENVLFDVHLFEKARLTQASTIGMDCSSISLPNPGNKEEWRVDVPMRSFQGGYYKKLISLYRFLGVGFRASNFSYSFSNLHASTHGRSQHAYCDAGRVEEREWAVVAWNEQGLGAPLICILGSADSVLLYSAAIPVGTIRAACWDPDHDFPDMGRGYDPQRFFGPFAEVGCCLEGFYGSHHDTVVLAVCTAPREDILKHPMEEFLDYIWLTLGTHHYVATNGVQDVVSRLTARISHIHLSSTISKISINPDNPSLAFIECSSSSGITTHSDFHHIILATQANRAIPLLQSLASSFPLKKTDRCRDIERQIDCLKRFSYAPTIVINHTDDTLIPGSLRDRRDLNLISAAEVLPEPKQDAVDADSVYLPSTYTMASHILQRPKCFPSHLPTVFQTTNPIVPIRQSRILSVAKLDRAVLTLDAKQALEGLQIEIKRSWQCAGQGKSRLGKLQGGGRVDDANTVGVWICGSFAHSGIPLLEGCIMSARNVVEQGIWRCEGYHDHIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLG5</accession>
    <name>A0A8H5LLG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLG5"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="78"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5361493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="39216" checksum="3BBD547B659EB986" modified="2022-01-19" version="1">MTMNETPECPAFLPERDFIGYGWDTPADCWPNGAKIAVNFVINFEEGGESSLANGDEYSEGYLHEAFHKAPLKGKRDQQLETMFEYGVRQGLPRIIRLFEKYGYKFTTFAVARALEVAPQYAKLLPELGHEICSHGNRWRSYADMQPEEEAKHVAEAIDRLQRLTGDDNVPAGWFLGRGSNQSKRLIAREHHKRKLPLLYSSDSYADDLPYWVESPLASEGVKDEGLLIVPYSLDCNDHRFLCQGSGWATSNDFLWHMKETFDYLYQEGVEGRPKMMTIGLHNRIIGRPGRFRCLQKFMEYISQKPDVWVARRDAIAKHWKEKYPYTGPLSKQNEYLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLJ5</accession>
    <name>A0A8H5LLJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLJ5"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5361598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="44390" checksum="3344FBD2B74DB04B" modified="2022-01-19" version="1">MASQLSVALAAHPIPKVKDVDSTSISSDSTVSTASSSTPALPPLVTAPEEHSTTPLRSNEHLAVLMPKHLWKSDSLAAVCDSFYCRTRFTLLERRHHCRKCGGIFCRLCSSHSTPLLDTSSLPFLHPPRNTPIVKYASPTSPVVQARVCDDCWDQLHGCPSTPRTPELTNSRPIALASASTSSSPSSSSPNTPPNGLGLVVPPHLEPQPTSQGLNRSLSRSSSKRSSNPDLRRRVTTRCTLSPHLPPLLPFPLSTDASCDSPTSPSSLISPTTSISSSISHHQPTPTPALTGPLSTYPLRHSSLQCKRTGGGRWTPQPLPVLAGHRLPILVGKELGKAPFEVEMEKEEERERRRRERPVIRDGPNGEFQIRFWRDHQDVAARDEEHVAEGEGAGWGKPPTRSYSLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LML1</accession>
    <name>A0A8H5LML1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LML1"/>
    <dbReference type="OrthoDB" id="2501127at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22954" checksum="5F9D4DD49A5FE6B3" modified="2022-01-19" version="1">MDLAPLRIALYFALSIFSIVVLGLAAARLHYTLNLPLGDPLNFGVSFHDPIVVELLVTSILTMLWSWHVIHVIHKRRETRFVSTFRGGFVVLFILWVMWLVGAAIATHASNPPQTNLRWGDLSSCWGFKACRILTAFLAFVWISWIVATIIFIIEILFVSQNNGALRGPYHGRWDPRRSEYGNEAGTTNMSQPRNTHMGFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ08</accession>
    <name>A0A8H5LQ08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ08"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="348" mass="38605" checksum="279D9D2DBFB1D4FD" modified="2022-01-19" version="1">MAEYAHLSTPDPDLVQALKAMSQMPRMTDFVTGRAAMKTGLLSHVQRKLKPQLPPDSEYEVQDYMIDTGDGSGAQVLARSVVPRKNTPDEKFPLLFWIHGGSWSMGSADMDDYQMRITSVKLRIAVVNCEYRLAPEHPFPIGLNDCHAVLKHVASNPEKFSAELSKGFIIAGSSAGGNLSAVLSHRVRDDTFFKERGVSLTGQALLVPIVIHREAYPELPEDYRSRLLSLGSITNAPGLTREDGDLAFASYKAPPTDPNMSPLLFPSHKGLPPAFIQVCGLDPVRDDGLLYERVLKADGVETKLIVYPGAPHWVEYWFPHKQVGKKFRQDFVDGIKWLLDFSSKDSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ89</accession>
    <name>A0A8H5LQ89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ89"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="418" mass="47943" checksum="F23A0E9C8BC2BED8" modified="2022-01-19" version="1">MSITPRFQCSQTAESIIISVYCPSVRASDVEINVDDTLFSLHINPYFLRLNFSHPVIEDDASSAKYDPGSGYLTVTLTKQVKGEEFKDLDLLAKLLAPRPTLPQKVPSEEPIKLSTRGQYGFLDMHFNYFVNVSYTENEINELGVDAETCTISERRLKRLKHEDEKFDEEYYMGDFADDENIQALIHWEHPHAIDSEPFQYTEKENMTMLNLPQREYLATPAQTHSLYLTLIAFLFSYVYQSRMDQHDPTPESAWTICSLIPAFSALDPPPYDQPPPSFNPSQYTPQEILSTLVASYRRSLAFPLYRSFALAEKCRIDVASLLSKGKRTVFRCLLEMKSILDHHEVYYIYSKIWVDDFCVWLQAYANDDVLTQLDALVKDVVVPKSAIGWDLEELETLVLSESNERVPDSDDESEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQG2</accession>
    <name>A0A8H5LQG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQG2"/>
    <dbReference type="OrthoDB" id="3254913at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="110" mass="12195" checksum="A38835BC49328EEF" modified="2022-01-19" version="1">MHASSSEPVEQNQVIDSEEQMEGPPAIAPLTLLPEITSLSDDLDLGSIIAAGDADVDKLNKRASNVQKLALENEKLKAELQAMSERLEAAEKRREELRHKKQEVKEPHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRV0</accession>
    <name>A0A8H5LRV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRV0"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="260"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="486"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5367071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63121" checksum="BFF3963EB4033ADE" modified="2022-01-19" version="1">MTLLSHPQLNSRSSNSSDPLNIRGAARNTLVGRMRRNAVSSVSQAGPSSIPVRISTRTGGKTIEFWKEMVRKRWNADLALLDLGNMIEDEIVKKNNLTPPGHGGSAREAAVIFKIASQLKPEVKSLNLSDNKLMGTHLSLLGHYLPRLANLSLKNNSVRTYRDLDALSGKKEKLLNLQELILEGNPLREEELQKGLGDKFKQEIIRRFASLSVLDGQAITQIAFDVPQASTSTGPAEKPSATTFPLEMGPSLIVGVDGALISTFLVRYDIRFFSVLDTQRSALREAYDAAATFSYSCNTSIPDRARIQAFHHRLPNQKKLEWSPWLTTPGAGSRNLVRLANSIEKQEQRLFIGGDAIVKCVEALPMTRHDISGPPEKFLSVHGEFVELPMEGLRSFDRTFILIPAPEGSRAKLNGWDVLIISDQWTIRGYSEPEAWKPGPMVVQPELTAHRTRAGKVKIDATSTQQTQSGLSLPPDQQTALMAIPEPQHSMVVQICGRTGLNIKYAVDCLTGNGWDIEKAVGNFNQVKFWSWSWLCFFACLPTRPETCLPISRSRCSVIQLVNSSVFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS86</accession>
    <name>A0A8H5LS86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_003742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS86"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="243"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5367494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36097" checksum="28789F842B141144" modified="2022-01-19" version="1">MDVPADALAPTPLSPAARALKEIAFGSIAGMASKVFEHPFDLTKVRLQTQVLDDSARFNGPIDCLRQTFKNEGIRGLYRGLPAPVVGAMAENASLFLSYRELQNLIRQFTGDPPSHKLPLHQLTLAAAGSGAITSLVLTPIELVKCKMQVQLLAPASALGIPVTTASGSATVPARLPGPISVLMSVIHTSGFRGLWLGQSGTFIRETGGSAAWFGTKEYVASLLIARRKKGSQNSDSSSPHELLTWESALSGACAGVAFNFVLFPADTVKSAMQTEEELRPRGPGATAPKSTFIGTFRQMYKAQGIRGLYAGCGITIARSVVSSAMIFVIYDELNRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSL6</accession>
    <name>A0A8H5LSL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1200"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="913"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1341" mass="147340" checksum="A2E6B24E66426340" modified="2022-01-19" version="1">MSTPKERHYWSQLRAALTAGQWLSSAPAKAPNGAPLPWSELFRKFNKHCRGYTDVAQVASATQTLAVLLAANSKSKNEDQDEWVVERKEGEYALELGEECILPAERKKDGLEAYEALKKLESANFDTLNFALAYYAYAVGNPTECLAHLAKVPEVAHVQNHIPLPSTLRASTFLAPSTSASAASSIAESSSTATPSLTPSATISIEEIKDGRAWAMAETIRSLCLQGMSHELLSPTDPKKALGIYAAVLPLLSIVETEFATSSFTPPSLTASGKGKVDFTCFTRFREIWRWVERLLWRAIVLGSRVYDLHHDHRQLPPEKACKNTDSLWTWLDHYTSCSAFWPSNFRTEHRATVSALYLRALVIRYGPLASVIKPSSGSEFMSDGPPAWMHTARSLVQEYRAILTVSTRFPRAGERNWKVEDFVDMCVAIWEASGARAEHTGWVMDVLQWSTRLTFNSSRILRHMTRLLYVSGDTALAKRTLRLYVQIVSKVQQTREAEAVQANDRNGDSLNGTEMETETPKDSERWIETLIFGIRMLCRIASSSSSTLVWGPGGSAWSAVGAGTGPTKSNWKEMMDDLKEAERLIEKAKVGIEKVGSKVQGKYEKEELLANLVLAEGVWNWVMGLKEQNPLTRPSYLSRAHSLFRQSIETHPTSGAHYHLALSYAYKHAYHSPGPTDGVGAGVAVNGTTATHINGNGHAHAHSIGHADFNADTAAEDSFLDSALLHVAHATELNPQEIRYWHLLGLLCAKLEKWDAAVGALDMGRSVGLGGDQTRDDDEFTEESEGASSVEGLPAGNDASHALFKAQASKEAKELQDKEKDKESAPPPPIEPLYILNSNPQSSTTSGNSSTIPPASGLLQPSSAIGQPQRYEAFEQALQLRMSEVTVTEYVEGVEVATDRLREVFEWVAERKGLGPGNGAESQARASFDGTRSGSGIMRLKSPSELRLGSQSGHGHENDTEHGDEKVAVASDSSFADGEPNPPRGRPSLQLTARQDSGRSDGTLKPPIPIPITISPATPEANTPKTNGNGEEEKDPMQSPTLLETRDASKPKKMQQKLKSQVGQVKSQVQKSGVRISTISKKIGHGVVRNGGLRRVSSTSDLHTVLRPMSYQASSIHSRRRNSFMRPSDSSATESPPPPPVLPPSYKQLSSKWNTRTARENRLLSDLWLMSAASFRREGKIEHAKGAIQEAEVKDEGNPGVWVQLGLYYIALGRIQDAIDSFHKALFISTDDIAATVHLSRIYLFPEEVSPSSPTSYSYKANPFNTIEHPNPENVDLAAGMLEYITKGVAWDIPEAWYFLGKAYGFQGRNEKERECLSWALKLSERRGVRDVLIALGICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT18</accession>
    <name>A0A8H5LT18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT18"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="226" mass="26377" checksum="987CCA35E94F8880" modified="2022-01-19" version="1">MLVRQQLLAFPAYLFFNVSGQRHYPKWTNHFDPSSILFAPSQRHLVVLSNIGMLTMAYLVWVASKEYGAGEVAKYYGIPWLGVSHWFIMITYLHHTDPTLPHYRQAEWNFQRGAAATVDRPFLGWMGRFFLHDVAHFHVVHHFFPKMPWYNGEAATAHLRGFIGEHYRWDDKPVFKALWDSYNRCQFVEDEGDVLFYRDKKGQAAKRPADAYYVKNGLGSNGVKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTW5</accession>
    <name>A0A8H5LTW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTW5"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="57391" checksum="C61AF157AA2FDC2B" modified="2022-01-19" version="1">MSSLPCASPTDAQALRSLVLKFAGHPNQLRYSKNLSGSTSARIDLFGEACTFGQDSPLNGWSSQFAQHDELKGKITFVPSFFMDPNSFNGFVDGGVMDGDFNWNGAWPVELTTASQGSSDTSLSSALTDLLGLSGSASAPDATNIIPHLSTFLGGFLGGSSNDNASPNSNVASKQTTDANQQTQTKTIASTISSALSKFIGSTDGDLLHVKGLGSSGSPSPSKRKDRTKDKEMEKIYMASVSPWFFTHFGADTFNKNFLYTADQHLYAKRWEALVNSSFPTNSNSPSNPLNIDIIQIISWNDYGESHYIGPIKGAQPTGSEAWTGGMGHAAWLPLTSYYASAFKNGGQYPDISKDEEKLVMWSRTHSAQAQVGDPVGEVTGKELVEDTVWAVTLLTEPANVTFEVYAYTPSSNANDNSSTIISSQTFSVPAGLTKLAMPIGARVLRSASGSGSESQDEDTQQNQDTTDTADTLVMQLDAGNPNASDSNANTGNGDAQRQGDGTGNGDGDAQTLAPFVFVKNPEKYNYNAWVGCVSSSGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU65</accession>
    <name>A0A8H5LU65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU65"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="22934" checksum="864C5997ECE5E073" modified="2022-01-19" version="1">MAETRQFGDLATQLVTESRRSTQADTLLKYNDSLVRSLIREQRDLEKAAESLDIPDSDNPPPALLIIQTAISRNKRCLLAYHSHRVDRLRDMYWAVGGALPHLLSNQDIRSKLSPYEVDYLRQYNSSVMEFRSEFSHELDITASIVNPPKDLHVLVHVVRDCGVIQTELGSIDFQKGQRFMVRRADIEHLIVQGYLEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUS5</accession>
    <name>A0A8H5LUS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUS5"/>
    <dbReference type="OrthoDB" id="3353107at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="242"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="760" mass="85234" checksum="7119F8577C28F771" modified="2022-01-19" version="1">MSLPPLPIPRHRSSQPTNVVQADQTLRDIYRSAISMLSLPSIDPRRTEYHLQTIARDAVPLLIAVEDLSGSSELKKWVYECAEEFGALCIRLAEAGAQPDEENPNIHFINPVTTVRTGKRGQPRKVIDPSYLCKAMNPKRRIPITVLAKALKVSTKTVTSSLKQNNINYKPSRISDRQLDNVVKTFQQKKPRSGEQYLTGYLRQSGLKVQRQRIRESVRRVDKLGHALRLQQKRKIERVPYMVSRPNALWHIDGHHKLILWGIVIHSCVDGFSRKVTGLRASTDNRASTVLRMFSCAVNRYRWPSRVRGDRGGENRDVSVVMILHRGLRRGSFIWGSSTHNTRIERLWVEVGTQFVWAWRAFFFRLERRHYLDRKNPHHLWLLQFLFLDTINDDCKEFQKDWNAHPISGLGHGRSPNDLFFLGQLRHGIYKDDCEGCSPEEIARSYGVYGTPIHRHAHQTGAGHSSDEESESESDCEEWYGIDDETNSADSWYGIGGEADDVEVQAQFESDNESYQAVDAPDHSKPFDQKRMMVFTDALAQMREEGRVPSGYGLLEDELGEDGYPGLETISTGRTAASPLAATAFAMAPLSTVAGIQTSNGDSRVFYQRSDGSIWSSCVSGHWESGGQTTCDVQIVPKAEALLSTPLAAVGDDNLNEWHLYFFSTTSILSEYVFQTSAISATNPSGVRGGASCTDCVTSELFQAVVAKNKALWAMREDDNGTQKLRVWFISAGQPTTITEAGKQGGDVWKLIGMPNSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVN8</accession>
    <name>A0A8H5LVN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVN8"/>
    <dbReference type="OrthoDB" id="3221235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59469" checksum="DEA22CC70B91A18C" modified="2022-01-19" version="1">MSSIVPFRESEQPRATIKSLSAEILAEVFAYHCSDCSLDMRWPESCYFDTPTLDISQTCQYWRNIALSQPELWSHMFISLRHDDSSRDLLELYLQRSFPALLTLAIDDIGYYGYEEGDEDDGSDSGSNASLTSYRSFVWSHDWDSGFWRMLHAVLVRNPRWHSVTFNIERARYITIFDKVDFEFADAQHSLINLRTLRCYWPEWSWSDCCSPRCFAFFAWLAEAPALETIQLSRYYPSFPLPSSRLTSFSFTCRKSTFPDLIVVLRKCPHLETLNLDTSDPDIDVSKMQGLVLPGLSNLTWKLGNNFEPSADILSWLTLPSLTTLSLNRSNGPTRNRGLCHLNLLDLLARSSAPLSRLTLTGDVVGPRHFLAELLKSTPGLTHLTIEVDERRKSHEFKLLTTALFTDLEVHLGQSKKQQCEKPPLPRLQFLDIACTTNTRSTLQLPTAASICSMVSSRRSRRILKLSGIRPLEYFGLTVLAPFDARCLLVENWLHEIQSGLDVLKQGGLNLHLWLDELDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWA6</accession>
    <name>A0A8H5LWA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWA6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="117" mass="13353" checksum="A769C59E90B86817" modified="2022-01-19" version="1">MCPSLYLISGNSQSLSSFSYWLPLFLKHKYVALRFLNQAAYECTAPLDVTPKPDVITRIFVLFQGVSEDELEEWTCALGRVEEGVDQWQDIVGVDKIKMLDTSLFRVLEWGGTMEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWT9</accession>
    <name>A0A8H5LWT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_005173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1266"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1301"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1420"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="121"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="805"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5372488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1449" mass="162781" checksum="88CF51AF564FBABA" modified="2022-01-19" version="1">MASDSGKKSTNDTDVSDSTLHGESSGLPAQAEHQLTNLARTFTGISQRSQQPHENFQLEPELDPRSGKFDFEKYIRWVVSILNRNPESNAITTAGVSFANLNVFGYGKPTDHQKTVGNLILDIPDMIRESLSGNKGRRIDILRNFEGLVREGEMLVVLGPPGSGCTTLLKTIAGETHGIPYDVMHRDFRGEVVYNAETDIHFPSLTVGQTLSFAAQARTPHTRLPGVTRQQFAHHMKDVVMCILGLTHTENTKVGNDFIRGVSGGERKRVSIAEVALSGSPLQCWDNSTRGLDSATALEFVKNIHTVSKYVGSTAVVAIYQASQSIYDLFDKVTILYEGRQIYFGRTDEAKQFFVDMGFLCPPRQTTADFLTSLTNPRERQARPGFEHSVPRTPDEFAKRWQESDDRKRLLEEIEQWNRDYDPVGGEHLENFRALRRMAQSKGMRPRSPYTISLPMQVGLCLQRGWQRLLGNPSMSISIVGGNLFLSLVTGSVFYNLETNTGSFYSRGVLLFFAILMNAFSSMLEIMALYEQRPIVEKHSRMALYHPFTEAMASMICDLPTKILNSLFINITLYFMSNLKRTAGGFFVFYLFSFFCTMTMSMIFRTIGASSRSIEQAMTPSSLFILALVIYTGFTIPKSYMRGWAKWIQRVDPISYAFESLMVNEFDGRDYPCSSWVPNGAGYENASGLERTCNAVGSTPGSNIVQGTRYINLAFDYSKDHLWRNLGIIIAFMIAFFFTYLLATEFISMSKSKGEMLVFRRGHVPHVKRSDDETGDKGEKPTVLDGHEGDDEVAMSNLAKQTSIFHWEDLCYDIKIKSEPRRILNHVDGWIVPGTLTALMGSSGAGKTTLLDTLADRITMGVITGSMFVDGQKRDDSFQRKTGYVQQQDLHLQTSTVREALIFSARLRQPRDVPDAEKVAYCEEIIRLLGMDKYADAVVGVPGEGLNVEQRKRLTIGVELAAKPQLLLFLDEPTSGLDSQTAWSICTLLRRLANSGQAILCTIHQPSALLFQEFDRLLFLARGGRPVYFGDIGENSRTLIQYFERQGADPCPPDANPAEWMLEVIGTAPGSVAKKDYAEAWKESPEYQAVKTELARLRGLATTKVSDQSASSKSDYAEFAAPLPVQFWLCLYRVFQQYWRSPVYIYYKLILCVISSLFIAFSFYKADNTSQGLQNQMFAAFMLLTIFSTLVNQIMPVFVTQRSLYEVRERPSKAYSWKAFLLANIIAEIPWQTLAAVLIYFCWYYPIGLYNNASPTDSTTQRGGLMFLLLWQFMLFTSTFAHMLVAAAPTADVASTVSSQMFMMCLIFCGVISSPDAFPGFWKFMYRVSPFTYLIDAILSTGLANNVAVCSDVEILNLEPPSGQTCGQYMQAYIDRRGTGTVLNPNATSGCQFCHVTDTNFFLSSVSSSYHLRWRNFGLLWAYIVFNIFGALALYWLIRVPKRAKSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWY9</accession>
    <name>A0A8H5LWY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWY9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5372608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58544" checksum="283EAC5C2A2860FF" modified="2022-01-19" version="1">MLTSSSISYLDAFAAALAIFLLFLFVFSWRSKNSLPYPPGPKGLPIVGNLFDMPKEKDWITYAKWGDLYGGLISLRVFGMTFIIINSAEVAVDILEKQNSKTSDRPIVPMASDLVGWRNATGFMPYGETLRNHRRLQHQLLGTPNAVKAFHAHVELETHRFLKRLLENGEGFKGHIRKTAGAIILRISHGYEVREEQDPFVDLAEEAVEDLTQTTSPAAFFVNVIPALRHVPEWFPGAGFQKTARKMRKTLNDLADKPLEYVRSQMAAGTAIPSYTSKLLEQESELGRTLSEEEKNDIKWSASSLYAAGVDTTYAILHVFFKVMLLYPHVQAKAKAEIDAVVGNGRLPTMEDRERLPYVNAILLELYRWHIVLPTLIPHLSTDDLIYDGHFIPKGAFILPNVWKMTHDPTIYDDPMTFRPERFIATKDKSPQKDPRQFMFGFGRRICGGRHLADVSIFLACAMVLSVFDITKSHDKDGKILEPDTEVTSGIASYSSDFKCTVRARSENAVALVQAELAHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXG9</accession>
    <name>A0A8H5LXG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXG9"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60624" checksum="C87FD8607AF11B93" modified="2022-01-19" version="1">MPSMYPFDSTLLDTNKVPEDKDMHAIQKVCTEYSQDLEQMNAQIQRLESMLLSITQKRDALQCKVSSLKSIISPLRSLPVEILQRVFQNCLESFPTISTQESPLLLTRICSRWRSVAINTPELWAAIHVVVPKAVHALEPHGAKYAGIREGLQSFLSQSGSLPLSISLQSATDGVYQNDTEETTRTLELLMPFHRRWKYLNFRVSLVSLVPLQYLRGEDVPSLETVTISRSHARGEQDFPEVRLPFLDNAPHFRKLWVASGFSSFKLTRPADWGKLTHLTVLYLDILLNDLVDIVAICPNLTECSIPLGGDFDRSTSLTLYKLQKLMITYSFMNANTASRFFNLLTAPVLREFKMDAGGTFSLDSWPTVLASIQNLFLRSACPLTKFSLKGSLDPPSLPEGFMRSMLQSMPNLEALEFMNCYFMTNDLLKALSVVLPASDVICPRLIRVQFRDTYAFFEEALMEFLSVRRSPPPLSAITPLAQVIVEDPRPSLSSRVAQFGKTVEFRAPSSSSVHMDVRNQQIWGRPTSQTSTALRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ64</accession>
    <name>A0A8H5LZ64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_000276</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ64"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="248"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="453"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5374766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="802" mass="88906" checksum="BFE1DA10F83BE929" modified="2022-01-19" version="1">MYLDKTISIFLSYHHVCKNLTLSSDLSFHQLSLFVAVSIMAHYVMTIDSDTEEPSNDVPSKKTNNEDALNPDFTFDVSGDLYFDLLDSQTNPDVLATGSKPNAISVDDIIARRKLSKKRKREADEEEEDEDDDEDEDDFDAGSFSSLGGDGTDEEEEEEEEDPLETSDDEAEQSGEEENLSEDGDDSSEDSEEETQAEKDRKAAFFDSETAVSSAHESFLTMNLSRPIIKALTTLGFHKPTPIQAATIPVALLGKDVVGNAVTGSGKTAAFTIPMIERLLYREKGKRAAATRCLVLVPTRELAAQCFEVGKKLATHTDINFCLIVGGLSLKSQEAALRNRPDVVIATPGRLIDHIHNSPSFNLDALDILVLDEADRMLSDGFADELKEIVKACPKSRQTMLFSATMTDSVDELINKPVRLFVDPKRSTSKSLVQEFVRVRAGKEAERSALLVTLCKRTFKTRVIVFLRSKKLAHQMRIVFSLLGMKCNELHGDLSQEQRLQALEQFRDGNVDFLMATDLASRGLDIKGVETVINYDMPGELAQYLHRVGRTARAGTKGRSVTLVGEADRKMLKAAIKHASSGDQVRHRIVPAEAVNKWVVKLEELKPEIAAVLQEEKEEKQIRQAEMELKKGQNIIEHHDEIYSRPARTWFQSGKEKQGAKEISKQQYEASAAASSSKRKEKDGEPKPKRDKFAGLSRKQKRRKLAMEEDAEDGSGNGLNAAIRSAKKASRPSKIGEPERRPQKAKSKDKKKGKGKKVTARVGGAFDRDLGSKSSRHEGVRAKKGDAIGGMKPKGTKQKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AYY7</accession>
    <name>A0A8H5AYY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_019027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000530">
        <property type="protein sequence ID" value="KAF5313532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AYY7"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5313532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="62982" checksum="5DD39AD313808FB1" modified="2022-01-19" version="1">MNKSHFPFPATSCIPNTWSLTEEKYKRIPGAFDRHFVCTRRWVWKLISGDVVLLTFSYITVKEDFNTGETVVQIRGLLFLREHVDYSPSSPSPEYGLASSFILGPNYLSPEPPLCQPPHVFHPASNQDACYIPENGDDPWVPCTTQPCLNRYNTQQLINIELPSWLHVITQLQELAIQKAHRKPKTESHQGTSTPTNQPSKPNPVPETPPNNPPEPNDPTPPPSLPTIPSAKGPSVAPRRPPTPPSPDPSDPNNSVMADTPPIRSNGTSERGRKPDAFNGERSKAKQWLALFNNYLHMNKGKYPTKESQVSLFLSFFTGEKGGDWATQRLIERDADEEDENLASTPGEWRWITLKQICDRFKKDFKALASEDVVRTKIKFARMKGTDISSYNSIFDTYREESEFREAVLLEFYQDGLPPKLQEAVGRMYPKWDDFEEYKERAVELHLEWLKEWERQGRWRTTSTKSSPGANSSFNLPPKLTPDERDRLQKAGACFACRQTGHMSNKCPTFLRTSSQNTSRTFPSCAIQTAETASPPPVTVAQASSSRKHDQGNLQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AZF4</accession>
    <name>A0A8H5AZF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000520">
        <property type="protein sequence ID" value="KAF5313802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AZF4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5313802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="159" mass="17768" checksum="A7D22EE1CF95976B" modified="2022-01-19" version="1">MSWISWFLATGFDAITGGITAINVVGKDGVPIAAKWNNEGMHTYLGMTVANYPNLFFSYGPQGPTSFCNGPSCLARLTFAEMQCEWIINCVKHMQDKGYTRVEADREAEKHGEISFWTSTTTRHYSPSRKAGIMVPTSQHINEVVDKDYEGFHFSKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BR32</accession>
    <name>A0A8H5BR32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="6">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_017452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000370">
        <property type="protein sequence ID" value="KAF5328040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BR32"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="564"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5328040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="663" mass="75251" checksum="737836837BFCBDB5" modified="2022-01-19" version="1">MKGFPSSSMDRPACLPIDEMALRHARERLCTTFGVPSLCLHQERASHFIIQGETTMYDVPTGGGKTLSFWYPLFYHSEINPHSRKVVLVISPLNALMDAQVKGLEEKGIHAVALNSNSKAEDLFEQLQDIITDTNKPLTCCLKHQVIVTLPETALKSTFHEQLLKTEEFKLVGVSVIVDEAHCIAEWGSDFCAHYNNVGKLLAQCPSHVPVLIASAMMPQDTLIYVNTQKEAEAIQDFLRAHCPPTMSPDTIEFYHQHIDEERKARVEEGLQSGALNIVIATDALGMGMDFKNVRDEASDDEGGEDGLNDDDIQELLHQAMDPVEREAVIDQAEPGYNSGSDAEPDPELLVKCKCKKVKSAREARDLAYLTFFIAMTRCCCLPWDEFFDNADKKPPTTSTCCDNCQPQSFPVERIILHLPYPTQAGRVPKPTPELQTELTTTLKLWCTQKIAEGPGVVERLKLDLFCHIIPWYWGTTKYGNEVLALISFYSALYPDPEQWHCEQAAREEEHCQQVSIIEKDRWNCLVSLFNECYEAMLELKTGEMVMRGWGKDKKEVPERKCNPFLRLPNAKHWPGYYHIIKNPISMPHIKQIMNMQPENRYATVSQYVDAWRTMFANAHTFNIEDSDIYHTTVELERSFDEKLTELALKYDIELPAGCIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTX3</accession>
    <name>A0A8H5BTX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000362">
        <property type="protein sequence ID" value="KAF5328463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTX3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="97"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5328463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="483" mass="54881" checksum="C857A61C62C0CC53" modified="2022-01-19" version="1">MSDEGIAAHSPGRHRQVLKDTLTIFHSISPQDEEKLALLPLLELRGEEAQYRLDILQTIADSPQRLDQRVRFLTLKTIFRLSQESQQYPRCYVIKNLVLGKRIARGAYGVLREGKIAIGGESGTGIERPHRTDYAVKVVELFPDCVEINDCIREAVLWRQFRHPNVLPFLGMYYQDDKREDDKTPSQEDMYTLVHDIASGLKYLHDENVIHGDLKPDNVLITDHFRACLCDFGQSRLASTRGFQPTRYRVGGTHGYVAPEVTRDGRSSKEGDMYSFGPLSYEILKRTYNLPGLKWLSTNKVDTTRPEGLPSTPDLDSMWNMITQCLAKKPSVRPDVKNLISLLNDMSSKPKPAPDWDDTDPLFTQVRSNVDHGGMWPPSGHPTHGRSQSTENATFDSSFFSEQLSGHNVDHDEEEDKFDIDDSSPEAAAINALNDRDQQLGQEKTKEVVAEEQLHQMFTAPRRRSLIPSLIKHPPPVNHVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0J5</accession>
    <name>A0A8H5C0J5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000319">
        <property type="protein sequence ID" value="KAF5331777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0J5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5331777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="37975" checksum="7E1E2415FE919AAF" modified="2022-01-19" version="1">MAEFNNYLWLNDQVYPTEDERISFFLTLFSGDEAKRWARSMMKKVFEEEDNFSDSDEEYTSTDEDSSALKPKTKKLWTLHEVKREFLRDFKPAARETLVQTKIEHIKMEGALADIDKYNSQFKRYADDTGYNDKALMKWYRKGLPRGLVDRISYLPTQPRNLAALQKAAIKQHMIWLERQEEKNSWSKPRREEGQLGRGSQNMRSSRTRSIEVNAFQDNVPGASSITKYPLKLTPQEREKMRREGQCFRCRGLGHMGNDCPTFSNTPPITPNNTTWRPSIKKTGIATETAEPGTNATTDNISELTTRIGALSGEEKEGLLKKFVTEADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3S5</accession>
    <name>A0A8H5C3S5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000254">
        <property type="protein sequence ID" value="KAF5334700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3S5"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="24690" checksum="B09C70EB7E34B21D" modified="2022-01-19" version="1">MTWDQSSIPSTFSVQGWYNFFLNMTNSDSFCSCRSFGMFQAFSDLPVDAQTNLTLLNEVLGGTCNLPGPDGSNDEGAKDECTNSLRDLVEEMMDSCQKECRERNGMRLLCRLGLLSSPIPPSSSHPASHYPIQTWAGFPDSAKPSCGPCERDLLKTYEGWFDSTGSGSASSDASTSDPQEDNDNDPTLSHLTPRSRWDSKRRMRMQLWRGFVEKGSLITLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4Q3</accession>
    <name>A0A8H5C4Q3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA breaking-rejoining enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000253">
        <property type="protein sequence ID" value="KAF5334719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4Q3"/>
    <dbReference type="OrthoDB" id="2506773at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58499" checksum="F0E9840D40773C70" modified="2022-01-19" version="1">MFKNPFKRSWSSSGPSDAQDAVAPRTTLFQNPFHSSKRPNTSTVLASPPTILHRNPFKRVPHSNSIPEISSASPPPLPTSTQVTSAVISTTHVPDVPTTSTQTVTRPPVDPTHLSTRTTRKANEIKPSDLRPPVLAKHRIADWETPFSLQQKEKYLSTFPQKVISSAEKAIAGSTVDVTKETYAAGLTRFTQYCDELNIDENQRMPADKLLIAGFVGEHISKVSGSTISNWLSGLKAWHEMKGAPWCGDDCWIRMAHRTAHREGVIHKRKPRSPVTLHHLIVLHKALDFSIPFHIAVWAVAIITFWACRRLGETTIPSIAKFNPKFHVTGEAVFCYFQQPDGTRAVSFRIPWTKTTHGNGADVIVSGLINDPEGICGLKALALHLHLNVNKDVPKSYSLFGYIDEQGNPQHMVKDKFLELCFDIWTRECICDVLGHSFRIGGAVHLLSLGLAPEYVAAVSGWTSLAFLLYWRRIVEIVPVAIHKAMELEKVKKAIEDYRKKQAISNTMIETVASGLSCTPNDFLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5E5</accession>
    <name>A0A8H5C5E5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5E5"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034252071" evidence="2">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33504" checksum="F2F42A6A3AC4AFA1" modified="2022-01-19" version="1">MLYILILITGKILFHSALAGTAGPGGPCSTTRDHLDPNTHKFLSDCSDQTYCSAQNGTCQPRGCRRDEFPFGYSPEDILPPLCPTGTFCPDQGDGCRLQVAVGGACQMDRDEQCAPAANWREFVNEENFYGSLCLKQVCMYANVTQGGRCIFDQNIYTDAGYDGRNVSVTIIRDNCRAPQLYCNQLTQVCERTKRLEEYCQLDQECELRNCVSGICAEPPETPLRVEAWQYVITVFCVMGAMVAICILLTLIHKRHRMQHYREIREYYFEQLSLRRSMIALHTAAADSGGFDFEGKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5R7</accession>
    <name>A0A8H5C5R7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000247">
        <property type="protein sequence ID" value="KAF5335056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5R7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="149" mass="16237" checksum="4E97C6D9C2A53D83" modified="2022-01-19" version="1">MLKATHCRIRTTMGVPGMHLRLSIRGVVVTGLVVALGPSRFLTRVVSAENSFPVNMSVAFVKVVGSCVEDCTFQVHIFHLQYLQASPPLSPSFNYAATRPQTSSRPANPAIFDIWPVQCFPKTSSNLIHTGAVVVGKIGDEFTSFNNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDH3</accession>
    <name>A0A8H5CDH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000184">
        <property type="protein sequence ID" value="KAF5339498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDH3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="18195" checksum="0AD395C282DA05A9" modified="2022-01-19" version="1">MDNVEGDELKAFWSESTPCFQLPSTSKTMTSRNGSRTEFEKSTPSPGAPPTDLVKADIGLGAESGLGLEGLKTPSPHPPSPYPPPHKGHPHLRERRPGRVYGFTTIPTPAPFSLTTLPPLPTTTTTITGPTSPFNLNLEPYADADAYNTGEGEDNGSDNFIGEEEDEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEZ6</accession>
    <name>A0A8H5CEZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEZ6"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5340504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="333" mass="38285" checksum="AF1131C1324B344D" modified="2022-01-19" version="1">MEGLASAFSGLPYFSPMMMVNRSETCATRRLSQCWGLGVYTNDVTPKFQGNPENATDLSRGDFFARKAIIEEVEQRCEEMKNEGKANHEWVPILYLYEIVKSSAKRERDWGHLVFTDLTLTRFLIVMIFPAACDCGNYSHHDYDALTRYQADRFMSLLHYLKYEWSESENQPNWVRATYTTPDQAFKLNPELFDFASRSTLSANSNSTALAKGKTKLPPIFHVIADNFIPTLLDSELEKIDNVVAQGMRKKRAEPSTRDRVLVVNPKEGKPNVNSKVWKNKNPRQCSFCEKVSKDKDLQKCSRCKLVFYCGKECQRMAWPSHKFFCKSVTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CF74</accession>
    <name>A0A8H5CF74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000178">
        <property type="protein sequence ID" value="KAF5340149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CF74"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="254" mass="28103" checksum="CE574241971663C1" modified="2022-01-19" version="1">MSIMKLVGATSTSSHGGGWQGHRSTKSTSTSASIAFSAIGNQPEHTQMHTRTRTRTQSILGLKAKPQPIIVPTATARPVVRIELVESTSSWPDYRPLDDVPSIAGTLTFPSSSSSLTPLPPNEHVHTPIPIPTTPTPTPAPEYVLGWELPSREAYHNKYIRSMYPGPGLQGMKDIHGWHEEVTLKKWRVRYGREGFSDCVPCRTRTSDGRFILVIGSNASRNEINVIMREETIAASKDVFETEGQGEPRWIRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG79</accession>
    <name>A0A8H5CG79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG79"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5340878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="251" mass="26582" checksum="673DDD2CD903C9E1" modified="2022-01-19" version="1">MAAYIRSWLPSLSSSSSPNESTSSETSPTVTIQQDVEDDEGSDTEKEDNDIPPAFPAISSAQRLSSSSKSSSSATSSSNGIPKILSDSQLMPPPPLPASRVPGVGSSSLSVPSSSTSSLAVPPTTTKPPTQLGVPKTKKREKVALAPGHSPLDWAALKSSGQDLRGVDSLMRITPSVLKQHNKRDDAWSAFNGKVYNITPYLPFHPGGEKELMRVAGRDGTKLFASTHAWVNVDFMLDSCMVGFLVPEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKN4</accession>
    <name>A0A8H5CKN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKN4"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034094451" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5343059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="501" mass="53638" checksum="6FC0D31540B0114C" modified="2022-01-19" version="1">MVSYFPYIFLFLSVSFKGFALSNEAAQIACNQLASTLGTTLIENSTGPDFNNTVSAPRNLFNTQINFSPACIVLAQEASDVQVAMKTIFQHEVDYAVLAGGHSANEGWDNVNGGILISFERMDQVSYDPQRDTITIQPGVRWGPAAVALEPQGVAPVGGRVDDVGTGLLLGGGLSFLSQAHGFSADNFVELDVVLVNGSMVTATAVNEYADLFRALKGGANRFGIVTRYEVQAIHTGKSEEKTWFGGSITYPEDSFEDLARAISHFVHDNVDPRAVHLSNFARVGLTTTATATLFYNGSTLPQDIFGEFLSIPSLSSNLTSLSYLDIALALAGTSPLGQGTLLGAKALIGGSSSSDDSTDQLYLNTLHLWKNLSDSFSPSEIAISTLDFTPVPISQISYGRPESGRGGNAIDPPLVGYNQIVIGNILPVGVKVVSEEIEDAVRLFLEQAPSSPGIPLFINECDSNQEVFATYGGYDFLKATYAKYDPTRFNIRHTNGPIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNB6</accession>
    <name>A0A8H5CNB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNB6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="390" mass="43211" checksum="DBA61BF3C106E379" modified="2022-01-19" version="1">MSSSTLAEEQYQVKKTEKQRGVDEEQARLAAELDASEDARLIKEYFESAGMQVPGGLQDLLYSDDAEESIAKKIALERDGKEDSIIVLIEFHGQTVQYIRLKPGAWLVVTTSSMDKPEPVPRNSASHKAVPLPLWDSDDDPSPHKPVTLPLWDSDEEPEIGKDECRDKKTPALRSQAPLCGSDPPKKKDGQNTSIAMYRAWCKVPSVFDLVSSWPNDEENIPVFVVTQGWHVGIFVSWKTTQHFVSYVFGPMYKKCPSLAIAIKWWSKCLNNEKLHPKVLERLVTAPPYPIMCQTAAWAGDSLIVESGQGGDVFSDSGLPIHFPALAPAALAPATSSRSSGPPSAPVTPRSTRTLIHIHDSDSETNDEYSQHFNDEFGISELRHLSSQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP07</accession>
    <name>A0A8H5CP07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1308"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1459" mass="161169" checksum="3F42FD4D4617365C" modified="2022-01-19" version="1">MTSTRSTASPLRDRLLSNTPDPIKSSILRESGMGWNSPPSDNSNGTATSPLRISKRDSSQPTQADLARRSSSSYRHMRNNNLVTKSPFKSQIPTPSTPSRNHPLPFPSGSRRVSGEKRPRPPSLHELGETENDRPFALKRERKQSKTYQGLIQKEPVTKSPFRVFPARDIEAHYSPPVPSTRLETVSRPLPSSPPKSSTPTGGPSPIRSSLVSKRMHGPRLSGGKKQKRKTVTWGEACDVIEISDPEDHEEEEESGALDSDEDFYGNPDEDDDADSFFRTPLADNCSVSNEPGPNEPGPEDSYDSIQLSDNGSNRLELDPDTSINGLVDEMFGSQRTSTPPRTSYNDHPTDLETEDGVPFGRSHHAERAKQFHEEILARSSPLPMPNLHSIPLPIHPTSSSTPPSTPPRHPFLHSPQTTSPPLGRTTHVERLKAVKVEEEEIDNDVQMLPDSPSPMKPSRCNDDTHSEVLMPKLDLGIDADTSMKTQHTSGPDPFELPNLQDEELPTGNDSSLHMDEDSRNLSTVSTEHSEVDMSAIEQESGEPNPPLLNTSMEASPMGSRNASFSLPTSPPRRSVLAGLPSRSSPALRSTRSPSPASPSGGRLRITRDDVQRRLLHKRSFGSPSPSNSPRSSLRGSASLQTLETKDQRVGASENDRDTVSVLTTGTENSAELATIETAEKRVVAVGTFRTHDPPETEHSMEVEKSMDYSELAQVQDGEEAESELEQKEQLDEEDDEDEDFGILKPPTSNDKLKLDFGSKFGLGKLGFSDADMEDVGANPSTRRSASEPGARNLGVVTIRPSDELSDNGRTGVAPVDVDMDMRSALDRLMEDVAGAGGVSMEHPSAHTSMSTEEDDSFTVNKRVLPVLPNPMERAATDSVLLGQGFLPSEVTSRSVSSSSTIPPPLPPKDNIRSREAMILEKRREIRRMEEEEDDVFHGRTGRHLTVGGGRPSRRRSMSTGDADVLDDKAKRGAAMRGQDPLLEPVESVEEDLQGSIEKELQKHASPRKKKYLIREREGTIYASADADRISHMAGPGDVNTGKAWRTVRRPSDMNEYSKQIKEYRAQDKSKAYGKVFVKVMGVKDLHVPIPNETTAFSCTLNNGIHFVTTPDCRFGKDGRIEQEFELIEHSKLEFTLTLKIRRDPHIIAQFKSVVPPPPPPPAPVVPPPMATQSSSKGGMRSFFSSSPKKKDKAPKQQQPPPPPPPQAPPARLNENLARYLKPDGTLARAFISFKDIANRCDTKIFESAFPLIGQRLEVGNKSSTLQVGEIVLQIFRLPPLPGLPPDQLPQSLEECHRGLRHVNWHKVTYFEGTLTQNGGDCTSWRRRRLRVIGANLVAFNDVTKKVTATINLKNAIAVEDNQDPHNHPKSPASGVTSRSRYDEYDGIYGVERSFRLIFPDDDEITFFADTDEEKARWLEVLRALVGHIPPHPLWAELLWQRFEDLNKARAANASQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ41</accession>
    <name>A0A8H5CQ41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ41"/>
    <dbReference type="OrthoDB" id="3054145at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034808793" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="67" mass="7146" checksum="DFB37714E0A09929" modified="2022-01-19" version="1">MFKFITATLLLVFATSVIAQEPLGLDGQCGTIVGTKPCAEGLKCCYLNPDDGVCKPASFEPCLFEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS66</accession>
    <name>A0A8H5CS66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS66"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="39" mass="4427" checksum="1A32A60CD8012AEB" modified="2022-01-19" version="1">MAEGIILLLAFQLDHLPTLALHLYAILKYSIQHVYGYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS76</accession>
    <name>A0A8H5CS76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS76"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="163"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="251" mass="27842" checksum="18FBEFABB896DBCE" modified="2022-01-19" version="1">MTVELQVFAPSVLVAFTGERLQASFAKEQLRHVGRMADKPSYEYIYPFPADTSESDSDSAHTALAPPPTVPQDSSSTPQFSPPSSRLLRVRVNNLPRSSLPSKAEIALHLPNPHHNTPLDLHPLLCLLLLPLITLLEFHMLRRPHLASLMVNVLMAESGGPTGRAATYHQSLIDHGHLYGSSHFDTWREFETEFIKEFMPEDERTQASLTLEGTASVDKYVDNFCALITMAGLNVEPVLYSTDPTEPTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSW9</accession>
    <name>A0A8H5CSW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSW9"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034233591" description="FAD-binding PCMH-type domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5346794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="668" mass="73874" checksum="C779284FA19A33B1" modified="2022-01-19" version="1">MKLQLFSLFSFVLLISSACRGEARRICKCRPNQWWCWPTGWDWDEFSTKLSTPNALIKNQRPMGAVCYPKDPLYDPVACQSLNYTLHGFDFAFMSSRINATNWYNYDSIIYPDYFEETEVGCPYFPLTPDSICEQGRVPLYAVNASTTQDIVEAIKLASKWDIRLVVKNTGHDAIGRAFGVNALEIFTYNMKNLTVHNNFVPKGAPRGTPPVPAMTVGAGVNWDQAYAAADAAGRTIAGGLSPMGTVGTAGWNLGTGHSLLSSHFGLGVDNSLEFTVVLPDASVVTVNEYLTPDLYWAIRGGGGPSFGVVVDITIKLHEAKKYTGAFYESYCNSDACFLELLTTWMKYHNAVADAGWSGIWPTCDRIFYLTLGTPYDVAPSRQTINVLKEFMEEAKGILGNHVTVSEFRDYDSFEDFCEKNLKQDPTAVGFNMTEIVFGQVQLVTSSWLLPREATAPENAAKMAKAVASVDSAVVVPFLVGGGAVNDPAKKSSSAANPAWRNTLVDMTIAETGSEFDDINVLQKTVHDDIAPFRAMAPPPYGGMYLNEADILEEEWQVAQWGEQYPRLLEIKKRIDPKDLLIVRMGVNSEGWDDEITCKTVTTSLAAYAFTRTKTVTTNLAAYAFTRTTEIASVWVLVVVLILTLVSLNWYLQLVDTRPVVSLFQAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CV71</accession>
    <name>A0A8H5CV71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CV71"/>
    <dbReference type="OrthoDB" id="3270175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF104">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16618" checksum="4309BE15473A1ACA" modified="2022-01-19" version="1">MAAIQDRLPMDAAINSDPQTELRHYLESPLEPQPQGEDSNINELDVIWWWGDTYPTLSCMAWDYLAIQGSGTLSERAFSSAGLTDHKSRNRLKPEMFAAIQTLKVAYRNGHISAHQQASEHAKDLQKALEEYYFGEDEDSESDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVK9</accession>
    <name>A0A8H5CVK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVK9"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24030" checksum="09A69B0CF8C1C18A" modified="2022-01-19" version="1">MRYLLEKICYRSLIRIFSLPDNHPVRKMASNAYWHRNPTTHSPPLWTLSRLFDLPAPSDVETITPLAHPPDYDVLFGCDIPLDKDQAHAGAAVILLDKQNPANNQVLRYQLSALKLHTTYEVEGIGVVLRLALLQNCLHTNQDDTNMIGLDSKSFIEATFNFKHRPRQYIIDEIHRLTDEILTDTSPCLLLTWVPGHMGLDGNEHADEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CY69</accession>
    <name>A0A8H5CY69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="3">
        <location>
            <begin position="114"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="954"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1292" mass="143365" checksum="D19AC2D6663A7DB1" modified="2022-01-19" version="1">MVCKKCERKLSKVAAPDPFTSSSSSIKDGSRKVGENKLLSRPGSSKNRFQPYQGKCKDCKQPCTQNKAKYCHGCAYKKGLCSICIQYALSVTIDREGLPDTGLDTKDWVSRELPPLEDMWDLNDFQIAAKNTLAARWYNSYRTAALNEVTYQDNLNIWSKIRINGFSFRDVSKVNLQTSILGHKFSAPFFIAPAAKAGHANKSAELSLASAAGKAGILYVPSISSTKSLEEIADAKVKGQVMFHQEYIWSNRSKLVDELRRMEKADYKAIFLTVDNTGVNGIRTRSSRFTGDTDETGHSATFDLQALAELRNLTTLPIVPKGIKTAADARKCLDLGFPAIYVSNHGGRVLDGAPTAVEILLDIRRNAPEVFDRMEVYADGGVRRGNHIIMLLALGARAVGLGRSPMFANIYGEEGVTRMIDMLSTELETEMKLMASLNARLKALTTNVDTLSHSLSDPKVLTFTHPVSHSLTFHKTGLVPSLLRSLSAHSALAQEYTKAKIIYEALLHLSGINSKYQALSALIQAGRLPETVEACRHLDQLLLESTVALNESSIMTDIRRKFNAAKARTEDQLNDAYLRSVVVSPYELVIYPSTEVRQSETLIDLDAVLTSMSPDSLQNHLLTLRRDVCTHCVNSLLTQPMSISATLERAHKLTFTPSPPNDEVLSSRLENLTETLEFLNFHLLSHLPPSQSSAFPKTLCKPISSSVLNNLIIPSLPKSFNDLRRYLSLVANAVAFEEQCLVGTLGNDPRDKPIRAWADEVGSHYERRRRELILDSTRQLVLTPEELSRTFEAHVDLPTPGPDIIVVQPDEDINGVADNANDAWGFDDDKEQENVDQNGEGAREKVDDSGDGDAWGFDDEDGSETTDNPPETNGHNHEEVDDDAWGWNDDEDVGEVEDDDPWGESKAKSDSQPSRPPPAPSIKSPKVATKLEKLANKGKKNLNGDSPMNSPALKTPLSPAAPKSPPTTSQQEKRPPQLNVTPKETFIVSERMNDILSIVKDILHEAQEFIESRLVSASEVYSHPGSILFQTAPSVLDLYRALHPVVFSAQMDSIEGPMRFSNNCLYLSGEVEKISKTEVGTAKDRLSECSQRLKILGDSWYHDTTEKYRQVINDIIEEGAAGFQYTGEQDRYDECESAMNRVLQETRRLAPKWKGILTRSKYYTAIGLVTDAALSRVLRDIIALPDIPEVESHQLSELCRILHALEGLFVEEHDPDQRSFVVAYVPSWLKFSYLSELLEASLADITYLFEEGALVDFEIQELATLVRALFADTPLRTNTINKIMNGHPVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZ37</accession>
    <name>A0A8H5CZ37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZ37"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5349771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="562" mass="62854" checksum="0EB2601067C90284" modified="2022-01-19" version="1">MGIALDTLILATGWAYVLLAPYTKIEETFNLHATHDVLMYGLVPSNIRNYDHIIFPGPVPRTCIGSIILAWISSPIIHLATSFGFVSSKFDLQVIVRLVLSTLNAIGLCLIRRAAQKRFGRLTGFLYAILTVSQFHIPFWMGRTLPNMFALLPVNIAYYLILDRAPHVTRPPPFRVDVAIWLLTASTVIFRSELLLLLSPLVLQWMWQGYISLWGAFKTGLLAGLASIGEIFRSGDSVERILNSRIALTTIIDSYLWGTFPTPLWPEFTSFVFNVVEGKSSDWGVSPFHTYVSTFVPKMLLSCLPLSLLGSLVDRRVRGFLIPYATFVLLISGLPHKEWRFIVYIVPPVNVVAARGAMWLLSRPRSNLLGRFAFGMTAAMILANVVISMLLATASITNYPGGEAMAVFNDKYPPVVGGRAPHISNLAVETGASLFLQEHAPPFNPSSLPNPESSWTKYDKTEHLTVSALTSRLEYTHLISEESPIDMEMLGGRKHWKEVARVDGFDGWSFDWGLLKDLTGGGMENLNVTGDEEKTDLMKKLRGMFRIRKSGKLWIYERKQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZZ6</accession>
    <name>A0A8H5CZZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZZ6"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5350228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="444" mass="47688" checksum="26C80D38152A0A57" modified="2022-01-19" version="1">MNKDEAIRCLGIAQKHRDAGNYSSARKFCQKSMALFETPEASVLLASIDAAEAAASSTSGSGSDSGQFQPSTSASGAETHPSSSGVKHRNTSSSTNGNANGTAGGMGGEKREYTAEQHAVVKRVRACKVTEYYEILSVKKECEEGEIKKAYRKLALALHPDKNGAPGADEAFKSIPGLVRPSETFHLRSQWCRPEDRFGGMPSRSSGFATSPFAGGGGLDGELSPEDLFNMFFGGGGAAFGGGGFGGGPTVFTASFGPGGFRTTRMGGGFPRAQENRQAAEPRSVFIQLLPLIILFGFSLLSALPNLFATPPILDPRFSFEASSRYDTPRHTASKGVNYHVNAIEVMNHPTIGAELRRQGIDLKKGKGQDIKPGPELAKFEAGVERTYINAVYTDCRRALDRKERLRDAEVGLFGIGTDWEKVKKIENEVIPSCVEFEKLNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0E2</accession>
    <name>A0A8H5D0E2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0E2"/>
    <dbReference type="OrthoDB" id="3265591at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034730450" description="Cytochrome P450" evidence="6">
        <location>
            <begin position="28"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5350898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26171" checksum="218016EC30BFDC7C" modified="2022-01-19" version="1">MALGFGLSPLPLVLGLVLILGFKFARACHEKSKLKHIQTLGPDGLLTSYITAFRWVTKATDIIEEGYRLFLNGIYKLPTLTGWIVIANGKAMVDDIRKAPDEYLSHAETAKEMLHTEYTIHPDLVLNPYHISVIRTPLTRAIGGLFSEMHDEVVEVMTEKIPPSEEWVPVRAHETSLQVVVRVANRFLVGLPLCRESWWCDLNINFTISVVSNAMLISLFPKIFTSNRRSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3A7</accession>
    <name>A0A8H5D3A7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3A7"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="64843" checksum="2C87D5B9BA7C544E" modified="2022-01-19" version="1">MSRDQPTPLEQRPHLPRHSSNQRACAPRLPNTFRALSLPPPLTMSSTTSSAPSTTSNSNTDGSASRSRTTSNRLPSLNQLAARINISNTSDPNAANGTNVSGVGSGSSEAGFPTNAPRPRLAAFALRTNSNVSLSATSASSGDSMAVNPPGTRSGSPMALSVSSVGSSTTASSVNGDGTEDGESGGEPLTSEKLEKLNEATGSNVTPIPADKKMVKGYKNIPSLDAIAKFAMQRNRTLSVDGSAKPPEPEMIEDPKTPGIQVKAPEHPLQYPWTIYHDTKAKFPFTPATASLDSASTGANSAGTGSGTAPSQPSSASFSTSEFAHHAPESTDYEAGLTVIGSFTTVEAFCRYFNWLKPPSKLERNSNYHLFKSGIKPMWEDPANANGGKWVLTMKNNPALLDRCWSWVAMALVGEELEEGADEICGAVVSLRSKVDRIQIWTRKKDDVERLNGIGKKLVKLLDVSEADGIGLEFQYNTDDRPLPNKFLSIQAMPGTGLQTKFYRGHLGVERLGALGNFGGAAGGGPVGGGVSLGGHRVSSVGGPGAGAGGEGDGAQVQGQGQNQSGPLSAGAGTGRGPGGAGFWKLWSWRTYILGGRVGGDEPRTSAVLVLVLVLGLDWVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5P4</accession>
    <name>A0A8H5D5P4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5P4"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="3">
        <location>
            <begin position="208"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5353673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="39735" checksum="47CBD7B8AFE831E8" modified="2022-01-19" version="1">MALLTESYGCLFIALFFSFIIFGFVLLWIFQYFARFPKDSLFIKTMVLTLGVFGSIHISTSFAWIYDKLINKYPIIFELDPIPATALVQLACIFVIAFLSQSYFVTRIWIRKYNFAHALSSGLRLTEDSVERETVDDSTNFRIGDPPTRSRIFIGKGSRGGSEGEGDTVNNGEDRVSNPVPVPVEVVHVPVHMKGTSTHDSGGSNEDEITSVVHAKSSFIYLQLWALGRAASPGVLRAENPPYDLVSASDIPISDHPKDDPRLRPLTIPEIKEYIELYAKAASNAVQKAGFDGVEIHNAIGYLLDQFTQDVSNHRTDEYGGSVENRARFTLEVVDAVVKAVGQQKTRIRFSPWNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D623</accession>
    <name>A0A8H5D623_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D623"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5353799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1154" mass="124692" checksum="A19992E60C060760" modified="2022-01-19" version="1">MFSITKIFKRKNYGRAYTRSTSQRTTNADNKQTALVERAYLLELSVLLNKLKTHETEGLSEEDANARQEEYGENLLTDQGGVSLLSVLIRQMANALTLVLLAAMALSFGVQDWVEGAVITAVIIINVTVGFFQEYKAERTMDSLRSLSSPTAVVIRNSEAICIPAKDVVPGDIVNIKIGDVVPADLRLLSTANLEIDEALLTGEALPVVKVVEPVRPQVMPDGQSIPVEVGDRINMAFASTNVTKGRGLGVVVATGMGTQVGSIAMALGKKDTDMLKSVGAEEEKVALKRKMYEKLMAWLGLRSGTPLQIKMSKLAYILFLFAILLAIIVFGVAKFRVNNEVAIYAIALAISVIPESLIAVLTLTMSAGMQRMAKQSVIVRKLNALEALGGVTDICSDKTGTLTQGKMTVRKIWMSLSLSDSDCADGQAAHRDLTVESGPEALNPEGRVFEKLVDGEVVIDPKKMDNGLRELVTVASLCNVATIGKNKENRWTGTGDPTELALQVFAHKLGMGKPSLVIPGSSGPAEGTIADSEFLSDPEKKKLEAIDEEKQESLDDLHVNKTVSNPSLHASHSYKRYRFKTEYPFDSSLKRMSTIYIDKENPDAPLLLLKGAVERVLDASIGYASGSVGGTGQSGEVEGVSSQDTGQSNVLPLDDAARTQIIATMEEIASQGLRVLALASRRLDAQAELKKLRARRSISSESTAVSSGVGSGQENKGTDPVEMMLGELTREEIEKDFVFLGLVGIYDPPRPESVRAVRACQAASITVHMLTGDHAATATAIAKEIGIVEPSAPKGAIMTATEFNKLTDGQIDALPQLPLVIARCSPETKVRMIEAGRRRGKYLAMTGDGVNDAPALSLAPVGIAMGMDGSDVAKDASDLVLTDDNFDSIRAAIGEGRRIFDNIQRFVLHLLSTNVAEVILLVIGLVFIDDLGQSVFPLSPLAVLWINMITSGPPAFGLGLEKPASNVMKRPPHSIKTGVFTWQVILDCLAYGVAMGAVAMLSFVAVVWGRYEGDLGQDCNKSGNFEECRAVFRGRSTVFATLTFCILYYAWELKALDRPLVNMTPGQPFWIDLWANQVLFWAVVLGAASVPIAIYVPGLNTNVFYQSGITWEWVVVVGLTVLFIIVCELWKLFARSKDWYARIGQGTRLAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D870</accession>
    <name>A0A8H5D870_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D870"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5355340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19674" checksum="02025DE6BDD39001" modified="2022-01-19" version="1">MLTATGYSAAINQLAYGAPPGLGPGDACGRCFALTATQDPFSPSYPGPFNTIIVKVTDLCPISGNEEWCGQTTSKTNNAHGMPFHFDICTDTGGAAAFFPQNHGALLGTFQETVDPNNEPMICRFRAVNGPVLMDPSCSLEVASMAKRQLIGRLLGAGIKSLLQAASPFNGTRGAQVGTELPFELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8D3</accession>
    <name>A0A8H5D8D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8D3"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="163"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5355431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="528" mass="59263" checksum="A8EFA1675343D144" modified="2022-01-19" version="1">MDQNTSTIAELRAKQVDQISDNLSRLSYHLASVSLNASADADSSSSSPLPRRFQWAVERLKGLFNQLEPKQLVVVLPRIRQLMERVNEKSGLGFREFDEFAQLLGRLVAIKESKNKLPVVRYLPYISDLPPSEVNGPAPPEWLAMFVHSDVPSVCIEDHNACCNVCLEDFEEPALAGEFQVGGGDDGTQTSPKPLRQLICGHVLHEDCLPMFQNDDYDDSDSNEKFECPVCRAKVWTSPPVSLLSSEIPRDAALNSISSDQHQTYDDYYNTLPPWQKMHGDLLDWIISLPISRLDEALDSTTHGRPVNEDALCIWSNQTYKRYLYSRTTDSPEGLVGCVILGSMTAQTLSDLVSVGDHTEASRRLREPEFQDAPRLLVVFAKHVDSDESHWVVHKFSLPDGALTTYHFHPELNACSDCRPASWWPAIRLAWPDADICPNPGMPTLIHLHRPMELAVDDSVAAAGIRYSILMGLPAEYSAVDLECLRGLIGTEIKNLHERYNSWTSYMSTFFGDLYGRSERVEGDRLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F175</accession>
    <name>A0A8H5F175_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000430">
        <property type="protein sequence ID" value="KAF5319856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F175"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="134"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="500"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5319856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="92612" checksum="AF84D3B4AC96E4B6" modified="2022-01-19" version="1">MSRSSLDSIIPARSFTNRPAPISVRHPRVIRADDSRSIDPACLPAQHPSSSPPTPRTRRTSSSATRSHHPPPAPPPSSPVSFPVPSYLDYSALRHLLRTDVSPTFGLAPSVSRTRRAYSPSSDSDEESSNLSPPPREMSIGQAVSPDQPLQLPTRWDAEACHNHLSISDNGRELTFQGTNSNGSDSNAAAARTIQPIPPACGIYYYEVKIQSKGQKAYISIGFAGPDVRTSRLPGWEPNSWGYHGDDGCSFATEKKGTAFGPTYGTDDIIGCGIDFTTHRAFYTKNGSFLGYVFENVGKIPNTGALIPLYPAIGLQHTGESIKVNFGHEPFRFDIDLHVAQQSNQTWEKIMSTPLSGRALRGVVGAATGTVGSASAGISGTRLGAGTEKEQVGDSMATSTSDLDSQTKLTLNKLVISYLAHHGYVKTARTFQKGIQMHDDSAGSASGTGTGDIEMADARASGASTSAAAGASGSTSGPGSSRGSGSPDLGFDFDFDFEKDISIRTRIVDSVLKGDIDTALEETGKYYPRVFEEDNDVDEDGDGDGDGDGDGDGDGDGDGSGDVSKRTGRTGRAGAMGMVVVAAEDGTGAGDRKAQQGLMLVKLRCRKFVEMVLEAAEMKRKMGALDDAQSHSQLHSHSHSHGHSAHDGIFEEDGMDMDVDDDGDPRPGSAINGVGAATNGGMSSTSTSTSTIPHPSSTSSYHSTSTSSPFPTSTSASSSTHISTAPRHQSQSQTQPPTSTITTATAAVPTTPTTPVIPTKSAYESALQRAISYGQSLDADYRKDSRASVQSIFRKSFSVLAFYDPLEAGGTVGEVAGHEARVELAGELNKAILKSQGRPTRPTLETIYRHTSACIHYLGVEGVGAAAFADMQKEFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9D1</accession>
    <name>A0A8H5F9D1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000357">
        <property type="protein sequence ID" value="KAF5328571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9D1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034708643" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5328571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="543" mass="58584" checksum="94282588C97798CD" modified="2022-01-19" version="1">MYLGLLALALASAGVTSAAPLAGPTVQLDSATVTGTTALGVDQFFGIPFAEPPTGNNRFRLPVPHPAYNTSFEAVSMGPACPQQAITIPLPDGIPADIVDFLIKTAFGVIFPDDEDCLTINVVRPAGISPDAKLPVVAWIFGGGFELGSPQMYNGATIVSRSIELDEPVIYVSMNYRVTAFGFLASQEVKDAGVGNLGLQDQREALRWIQKYIGAFGGDPEKVTIWGESAGAISVALHMLTNGGDTEGLFRAGFMQSGSPIPVGDITNGQKYYDDLVDQTDCSGSDDTLQCLREVPYEKLKDAVDNTPNIFSYQSLNLAWLPRADGVFLTDAPQKLVEQGKVAKIPIVSGDCDDEGTLFSFSTLNVTTEDQIRNYIKTEFLSTISDEDLDTLLQAYPEDPAQGSPFDTGDLNAISPQFKRIASFQGDAVFQAPRRWFFENLDGNQPIWAFLSKREKAVPILGAFHGSDILNAYGGGGMADYIIRFTANLDPNGNTGISWPQYSQANPTLLTFNDGVVPQSLSKDDFRVDEMKTLNQILLANPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAU7</accession>
    <name>A0A8H5FAU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2751721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DNA polymerase beta palm" evidence="4">
        <location>
            <begin position="233"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="5">
        <location>
            <begin position="544"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5330071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1341" mass="150314" checksum="0C2BABF34D43D334" modified="2022-01-19" version="1">MGNEESVKQDKETPTQPLPKLEQKRRTPSQRLSNGPTSPLINAHRPKHLFDLSLALASTTSDYPSRCVVLQIRVMIALSLRSEDMAPTMSLATPPGTTRRDVPREERPAVRAKETVRPSERLMTLGRGEKGGGGAALGLLGRRMGTLVEVDEVGDDVAQGVREVSEADCLVHRRPVSESTISCTLLLLFIEQFSQSERADYIYICLVSKPEPYQCVIVSIDNLNSFVLAAQLRTALSLNPNLFVDIMGSYRRTVNLRSLVHRGKADCGDIDILITRDTADGRTHQGILKRPPKKLSQANILTEDIALPVDYDDEEAIYRRLCHLPNLPGAKRRINFLLLGLTEPPQRLQALLLNMPNIFSRQSKPKQKDAIPSGFDWSHAKTALSLAASVGKAAGISHLEGAAEIAIKIIEIVETMKKNKEDCISIARDITDLLDVIKDIMERGRNIKQNEILMKNVQKLESDLGIIKTKLVKISNRKTKFHVTSDAEIIKECKGKIRDYMEIFNTKASVNIWQNTGEILKGQEDLKEAMAHIAKTHDQSNITYDDLERITPTASPVFFGREELVAEGVDHLVNNSQAFLAILGAGGIGKTSIALHINNAPQVKTKYGKASYFLPCEVLPDAKLLLQGLIQRLGIKVGQGESQHKKLEDYFRFNTQSILLILDNFETPCNNDPMGIENLLGKLASFDQVSMIITMRGSKGPASLHWKRLGSETIPPLSLESAKKVFMEISRKEELGDENHVVETILNELDCVPLAITLIAKRAVAFPPKSLLRMWQKGKTKILKQGKADGRLTSVDYSIKLSTNLLEPQELELLAIISFLPDGVPHWEENLCEMLVGWEDLDQSINTLLETSLVYSQNKTTKVLAPIHEYINGTGINIQRGIGLLESFYVSWLKQLSGTTQEKQEQIQPHILNITKILKEQANSVSKTLDVEAVYILTGFRKFYPLTLDILNDILDKWPGLNETHKVEIRFKKLYMLSWLAMWHEAEMEAKGMEQSMQNDLKSHARVMRELGEIYKLQDKYTEAADMLIRAKDQFEQIGDQLSAADCLRRLGNIYRMQSKYTEATEMLTKAQDHFEQIGDQLGAAQSLQGLGEIYRMQNKYTEAAEMVTKAKDQFEQIGDQLGAAQSLQSLGGIYRMQSKYTEAAEMLTTAKDQFEQIGSQLGVAQCLRSLGDIYQMQSKYIEAAEMLTTTKDQFEQIGDQLGAAQCLRSLGRIHDKQANYTQAVAVLLMAKAQFEKIGNPDAVADCMYCLGISYRKQGLYENAKSALADAIFTFQNLGNLYDAGWCLYEYGLIFMNEHQYSEARRKFEEALDTFASHGELQNEVEMCNDELASLDELEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEH4</accession>
    <name>A0A8H5FEH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000283">
        <property type="protein sequence ID" value="KAF5333851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEH4"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="42723" checksum="8C246807F8D47C31" modified="2022-01-19" version="1">MDRHVSNPSELPQKFQRFRILVIGRAGAGKTTLLKRICNTTEELCIYDEQKRNLLEPTADRGDINRPFSFSSNPQFIFHDSPGFEKGGVKELEDVQQFIKDRAEATNVEDQLHAIWFCLVTHAARPLLELEERFFKEKHFGNVPVIAIFTKFDDLVIQLYDEDKEDIEVRNDAAAYLEDKFRKPLAECDNPPSAYLCLEDMQQDDGNHQQQSLSVSIQQNDSDPRNEYAVKYESSQINIVHGNQTQTTMNDNSQTVNSHNINDHRYFDQRYIDQRYIDQRTIQVIHPGSVPIPWGSYAFGVGGTVIGLASSTHHVTNFCHLQQTRLNITEGADNSALYDPRNPEFTLVFLLLLTTFPRPVVNLINDFCGAISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEQ1</accession>
    <name>A0A8H5FEQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEQ1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29802" checksum="1C87459CDF08222B" modified="2022-01-19" version="1">MADKTIILYDFPSKNGSWNAFVIRIRYEQKKCNKYCDLPILLHQACAEVQRPSFQNRLDRISDVESTLKAAGIPPTAQWPDSGKPSYTLPAIVDPSTGAALADSLVIAEYLDKAYPDKPLLMPSSTKALQLAFEQAVLSSIGPMFFQFILIKLCDVVNPASEEYFRRSRVSLFGKSVEDLVPKGESAKEEWKKLEAGFGKIAGWMKEDKFVMGDTVSFADFVIGGWIITSKIAWGEDSQEWKDIAGWHDGRWSKLVKNLEPYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIL6</accession>
    <name>A0A8H5FIL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIL6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5337947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="615" mass="67751" checksum="97DEE74BEBDFDFB2" modified="2022-01-19" version="1">MSSKGYISNLSQIGEPAGSPHSSDSDTYDVIVVGGGTAGCVLASRLAEDPSINVLLLEAGGSGKGQIFSRIPAAFARLFKNRKYAFPFWTEPQEFVNNEQKFWPRAKMLGGCSSINAQMAQYGAPGDFDEWAKITEDESWSWKNFGRYFIKFENYTADERYPHVNMAVKGSGPVTVGYNAYFNESSKDFIDGCKNLKIPFSADFNTTSGTRGVNRISECQLIVTYIDANGTRVTSETAYLTEEILSKPNITVGIHAHVTKILFENDGDTPRAVGVEFTQKQDGPLYRAYARKEVVVSGGAIHSPAILMLSGVGPRDELEKHKIPLVKDHPGIGRNLTDHPTIDLYFKDQSNTSPKWMIPSSFMDVLHALKAAAQYLLFSTGPLRSNWGEAAAFVRSDDPVVFPPEEFSAATLSKDSTSAPDSPDLELFAIPLAYRSHGKVGWPIHTISLHCCLLRPLSRGTITLKSASSWDDPIMDPRYLESKDDLLKLVRGARLVMKLAKTEPVASRVDQNYKGPYSDEMDTHMIEKSDEELMDLVRQRLETLYHPTSTCRMAPERDNGVVDSRLRVYGVKGLRVCDASIFPSIVSGHTAGACFALGEKGADLIKEDLKNAKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKS2</accession>
    <name>A0A8H5FKS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKS2"/>
    <dbReference type="OrthoDB" id="2786563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="145" mass="15286" checksum="CD0B7D93BC6478B4" modified="2022-01-19" version="1">MRVQRDVACRSDGSLSLAIPVALFPAFPPPAPTLAPTVSVNVNVNSSPIQAPRYLPALPSPTLPTSPSPVTLLSQGLSTLPSLFTISTQLPKEWNDVLLTVSKNERLEKILLRSARPTATPGSKKMSSDASAFGVSPQRGRTGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMA3</accession>
    <name>A0A8H5FMA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMA3"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="256" mass="29267" checksum="7A206F2177804DC3" modified="2022-01-19" version="1">MNEEDEDAEDKVITFYDFPSKKDGVEGWNPFPVRIRLALKYKGIPFKTVWVEYPDVELTLKAAGIPPTTQWPDGKPWYTLPAIVDPSTGVALADSFAIAEYLDKTYPDKPLLMPSHTKALQTAFNEAVLAHVRPIFPFVLIKFCGLVHPVSEEYFRRTRIVLFGKSVDEMVPQGENAKEEWKKLEEGFGKIAGWMKKEDEFVMGDTVSFADFVIGGWLILSRLAWGNDSKEWKEIAEWHDGRWGKLVKSLEPYYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNG4</accession>
    <name>A0A8H5FNG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNG4"/>
    <dbReference type="OrthoDB" id="3361009at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="103" mass="10974" checksum="445B522B05B4E62D" modified="2022-01-19" version="1">MSTQQTPPTSEGVRMPSEVVQPTRSTTQPQQGATQPDSGHAIHTEPDGTRVVEVPGPQVPFKEQVVGYAKKTRGTLLGNHETKEHGEAILEGKASISTPPAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNJ7</accession>
    <name>A0A8H5FNJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNJ7"/>
    <dbReference type="OrthoDB" id="2537480at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034517220" description="Transglycosylase SLT domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylase SLT" evidence="3">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5342973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="284" mass="30501" checksum="D0D91F890AC7C75C" modified="2022-01-19" version="1">MKFDTFILAALASAVLVEASNPLIARHGRLAQRSRLPESSLRKRSTKCKNRSIPSSSSGESTSANTSDNNNNQGNAQITTNVNIASLPAGGGTWDITTTSGPNGDIDYLNQGINDGVVDLTQALSDPNSPFHACAPYVDMFYNYGRANGIPPIILASFAMQESTCNPETVGGGGEQGLMQLTQEKCGNAPGGNCRDPDYNIRTGAEFFARTLNDKGGNVVLAIGSYNGWFQGMTYTQATAAAFSSCCRCQNNLDYVFQFLNGWCQNVNAYQMKLGKYFNLAVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR05</accession>
    <name>A0A8H5FR05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR05"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="28851" checksum="D80165E5AD86D41B" modified="2022-01-19" version="1">MLGYGYGGTPKPMDPQLYVSSLFTRDIIDILDAEGIDQAVVVAHDCRLANYFPERFPCLAVGYITPTFFATPFEENLNLSKAVLGYENFGYWDFFSSDGADQTILDHLDSFWDIVYTKDTTKMITDWSPLGALEAFITNGIRIPSVDYVTPEERAIQMEAIRQGGLAAPLSWYKIARGTLEGQDDQGIPPENAFIHGPVFLGAALRDYVSVSAPSFLAGALVSSNSTATIREYNSGHWVQMALPDEVNGDLLEWIEGLGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRV8</accession>
    <name>A0A8H5FRV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRV8"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="194"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5346423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48119" checksum="3D558884D24E2C12" modified="2022-01-19" version="1">MALLHITRLSELISQSVSAVCNEYRTAGQDLPVLHSTNVGPFDAPEKTSETLQTAIKTIEAACAQLCATIANPGHVITNKVYNYFEPACLRVATEAKISDLLLDKPEGVHVGELGAKSNRDPDKLSRILRALATNHVYTEVSPNVFANNRLSMKLLSSDPVSGLVEHMSDEAMKSTAVLADQVADPKAGFSVQVEDTAFYKAHGMSVFEMYAKDKLRAERFNQAMVGWAQVTGRGMVPKIYPWADLPKGTTVVDVGGGNGHAVLDIIKAFPHLKVIVQDTPAVIADALKFWQKENPDAITKGQAILQPVNFLEEPPVSDGDIYYLRHVVHDWSFDMAINILSNVRRAMQPNDRLLIHEFVPQPIVDGGTAKAPEPLLPNYGAALKRLYFQDLNMMQFFYSKERTLDEFMNMGDTAGFEFVKLWDGGEAGIMEFIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV20</accession>
    <name>A0A8H5FV20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV20"/>
    <dbReference type="OrthoDB" id="2979847at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="188"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5350815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="618" mass="69980" checksum="34195C2C63E0472B" modified="2022-01-19" version="1">MPEPPPMQPTPDNSASKGLLIPDAIIRKLLPISDPGLITDQTTLCLALATMNSKNIPDDIDEHITWPPDNSIFSKEPSPIQSANQTLFLKSQCPMPTLIRVNKLYQCSTLALSQGHQTFLYNLPGVTGSPIPMKLPMWVLLYWLWVYQIREHHTAWKEGLVWLEHNRFVGHEVDVLDPLPWQLEFPCNLSSPLDLSRFLQDKWLNAENINQMLAVLDDELQQGFPIENIYWSNTLVEAYRRKDDNSYRCNRNLDLVRNQLRDGVRKRIVFPVFVCLRGFTETLLPAPNVKGNHWGAVAIDVDEKSFSYGDSSCGRVAPELLEAISWFLAEPFPEIVFIYNEHGLPAGLQNDSDSCSLYCVNTISHFLASERYPMYTTENPAVLRRIAFEKISKLILKQTNGLKQPGSSVPPTPNLVPKMPNQPMLRSKPLTSKPPPPKSDAQTLLAPIFTKTSKKRERNSETNAAKTTTEDWFSDTDDEDDGESIEGDLVVLLLPKPKATGAPKNQLLDQLLRLCHRPQTPNKIRHKCMAEKCQTSWSKCSLTRAVKHVSKCVFVSQDLKEKADEILLCKAPSTVVEWLQEGNQDSAKEPKQKKVKLVSDNLIMGNWMEEAKKLSREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW43</accession>
    <name>A0A8H5FW43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW43"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5350892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="52512" checksum="E959C0C6BEAD83D8" modified="2022-01-19" version="1">MESGITPTLRVVILCAVWFGISIPMLLLLFVTSTAESRRTALFVANAVALLTAMSLGLSNIIILMNSVTNPAIDVNRDGTLAFAYILIIVEIFIDSILLMRVFIVFPPQRTPRRTFIVIFVPLVVLKLTRLSLAILFMVNFDRQTRDVQNSIRFGQLVLTRIEPKIAWLLQVVDNSLCSVIFLTKLHEVRSMSERVGGQDGRVVLSFADKDYTHFLLLLISNIFVEAFGVLFATIWATTSKKKESSARAVEEAMFSIQFATPSSRTHNTGGRSTDTTSTVDSLPGRTHRTDGSTSIALQKIKEEPSVIFGCSYFVDSDEHAEIMVIWFAYLFDIMDIFLYEHNEKLEDPIAQKQFAENLDFAEVLGAESVVLTDIFSGIRITKKRRNGGRNKKGRGYVSFLRCSNRSRCVSKDKAIKRFTVRNMVESTAVRDISDAACQCLPRVKRKVRKKVNPAVAAAEDAKAAAAAGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWF2</accession>
    <name>A0A8H5FWF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWF2"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="79"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5351283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="634" mass="70279" checksum="D1DA157FA40F7FB0" modified="2022-01-19" version="1">MPYFKDHGLQSSTISAKRSPKWLNRLKRVSCFLALAFIILWTFRPELMHRCQKFLAGLALSLGFQVGVSNALASPYAQPNIVLIITDDQDVRTDNLLYMPKLQKHVAEQGMSFERFYAPVSLCCPSRVSLLTGQFAHNHNVTYVSGPFGGYPVFCKNGYNGESLPSFLQDAGYATYYTGKLMNGLSEPAIKACPTKGWTYADFLIDPNAYLYYNASFSANGDPAVNYLGEYQVDVIQEKASSLLQTAISGLKNDSWSTPFFLGIAPTAPHLEVQFNGSFTEPLPPPGDEHLFDGVPVPRNPNYNVHGGVSWVKDLPELNETVVEYIDHVYRQRLRTLQSVDTLVETIVQQVEEAGIADNTYIIYVADNGYALGSHRRQPGKTLPFQEDTLVPFIIRGPGIPSNSRNDAVHSMTDLAATILDVANASASYPVDGRVITFDVEDDGSGHTIVEFWNAALEEGIYAFSTGSVESRDNTTYRSIRAVDGDEHAWVYGVWCTGERELYDLKTDPYELTNLALNSPSQEFDSFNFSTPSLTSLASRLDALLVVLKTCVGEVCRDPWSAVFPANSTDPAEQKDQAPVGGQSPVTRLSDALSPKYDAYFESLPKFKYEKCQFGYFEDLESPKWEDGLAYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXE2</accession>
    <name>A0A8H5FXE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXE2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034709548" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="562" mass="61761" checksum="5CFDF64DCC4C4096" modified="2022-01-19" version="1">MKVKDQDAMLHLLPCLLSLLSASSIVLGVSEVKIGGTTLVGKAVPSLQQELFGGIPFAEPPVGPLRLKPPVFKDTYDQKILNVTQFGFPCVQYDLTLDQSSEDCLTLNVYRPAGIPSHVSLPVLFWTYGEGFDRGTVIDASALVARSIQRGTPIIYVSFNYRLGPLGFPQGKEAEEKGALNLAIKDELAALEWVHKHIQKFGGDPNKVTVAGVSAGAIMNGILFMHPSTERLVRAGIFQSGTAGTAQVHNASYRQDNWDKFISSVPACANRSGTDNTFDCLRYANITDIVQGVNGAREKIVEYIPWDPVLDGALFPAAPSVMRKLGQFARIPFIAGTNLDEGTVFIDPTQNYTSDLIRANFVTNLSTPLLETTEKQKFDDAINKTLELYPEDPALGSPFGTGNDTFGVSPGFKRIAAITGDVSFTSQRRTWQQTMANNPSSGVKSYGYLWKTAVLEAPPFPGPIFGVWHGSDYHYLYNDTIVDTITPGALEAGVTLMDYFLSFVDSLDPNDGKGVQRPKWSVYSQHEQMVMQMQAKNFTQIPDTFRKEQIDFINSLPDIFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXM6</accession>
    <name>A0A8H5FXM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXM6"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="10">
        <location>
            <begin position="83"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5352946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="406" mass="44254" checksum="71AAEC089C44D897" modified="2022-01-19" version="1">MTQSTIKEGTRPPFRFPVPDTDNDMYSSSPYPDFDDADRVQQYLQDRRVIGYDPLLQPALLRHEIVSTTNSHRTIAAARYSAAKILAGQDDRILVIVGPCSIHSPDQAMEYARMLKSKIPSWQNLLIIMRAYFEVKCILDKPRTTVGWKGLINDPDIDGTFQINKGLRTARKLLCDLTDLGVPVGSELLDTISPQYIADLISWGAIGARTTESQLHRELASGVSFPIGFKNGTDGSVSVAIDAMQSSSNPHAFMGVTEQGLAAIVKTRGNQDVHVILRGGTKGPNYSSQHVKEAATVIEMKRGSASIMIDCSHGNSQKNHNNQPLVIADICKQLEAGDRNITGVMIESNINDGRQDVPPGGPSCLKHGISITDACVDFDTTVRMLDTLNKAVASRRAAIIDAGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2R9</accession>
    <name>A0A8H5G2R9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2R9"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5357296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54415" checksum="5A939BDC5D169CAE" modified="2022-01-19" version="1">MANTTPERFVLCPKCNTEIPLSVNLNLEPSTDDLTEKLRSYYTLSESELTNTASSVEDLDQRISWYDEEIGRLETILRAVQEQRELTSVSRAKKAASLNLGVRKLPPEILGQIFSLYCNDTNNGFRQRHTSRPYVAPLSLSHVCSLWRAIVHNFPNLWTIIHPDTSPGGSELVSLCVRLSKQLPLTIHLTGTSSLSVLTRYSDRWQSAFLELTFTKFQYLVQSSISFPLLTVLAITIQYSHPAEWLFGLPDADSWVSSVREGTFDDISPILRELLLDVPHSLPPQDYNLWFNRCTLPLSRITSLTLVGVGEECCEIIQHCPSLECFQMDSYRNTLYHPDMNMSNLKIFTSNITSLTISASDHQSAQVISGLFAFLRLPHLQRLEIRSTPCRSVEWSMNSFSSMMSRVPCPLSIIHLEYVYISQYTLVRVLDMMPNLTLFSLSPVPQLWTKDDQMVMVAKGFEELGIGIYWEKESILAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3I3</accession>
    <name>A0A8H5G3I3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3I3"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="390" mass="43182" checksum="7C2BEF05DDD9FF2A" modified="2022-01-19" version="1">MPTPVPVTLSVPQELPPEEPEDAPTPGPTIPVIEGPLELSSLILGAGTFSNQYNTDDHLGSFAPMRLIRLALRYGIRTFDTSIYYGPSEVVVGNALKMIEAEFPRSSYKLMTKCGRFGATTFDYTPSVIRNSVQQSLQRLQTTYLDTVYLHDTEYVCTPVAPASTGNHASALKEQAAAYGLAEGDETKIHGEGDQKILDAYAELRKMKEEGLIKNIGITGYPVPTLLRLALLILHTPPYQPVDVVLSYSHLTLQNTLFADFAPHFRERAKVGQLVLASPFSMGLLTPSIPPWHPAPPELRAAVTEARHQYGEGFTDLALGYSIKRSCLEVKTPMVVGFSHAKEVHECARVWRDVQENAYKPERLEEEEKARKLIEKSGFLDWSWASGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8F6</accession>
    <name>A0A8H5G8F6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8F6"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5360166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="17002" checksum="FEE7EF76DCD5E791" modified="2022-01-19" version="1">MKHGPFKFLTSTTVPVLHIMFSLIRVSVLVAALALVTKSNAQSQAQCARNYTVHLGDFCDGISAAQHTSTFQLANANQGVINTDCSNLAVGMARAPSPLCLGDLGKDCSTVTVVESGVGCATIVDNAGIALDTLLHNNPNVNADCTNIYPGEVLCTSGGLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA59</accession>
    <name>A0A8H5GA59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA59"/>
    <dbReference type="OrthoDB" id="2355984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="342" mass="37450" checksum="1704E14E42C54213" modified="2022-01-19" version="1">MVQGMSDQDWKGGLAAFLEMLDNADKEEDEAVVRGKKNSDESSNDNNIPLPLNDPSFPNKKAAKDDDTEYPWSSGNLLSAVAMDDLSPICCQTLCLLSKNLEDPKKALHSLLSSPLCLDLPESELKAILLSKPVNLDVVFTSLYSNMYTEDRMEDLADGIQIRFGNQVPSKQITDSNEWGVVWHKVRTAYARIFLTLRQTSRPMGNTFTSSWHLSRNPSTPGSFILTKQSTSKSPIPAPSVSLISAFSLISENPISATQDHVKEAPQKSNRTTPTKSRVPCNNWNMGFCTASASTCTRLHICNVCDLPGHKGPKCPLLPNKSTPPSSTLPSKPPPSNVPAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAX6</accession>
    <name>A0A8H5GAX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAX6"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39834" checksum="22F5DD3A5F843B73" modified="2022-01-19" version="1">MPSKFTVQKDSDVKVEYDPKDMPFRRLGSSGLRVPLFSLGGWLTLGGTVTGDPVKDIIKTAFEHGINMFDTAEIYSNGKSEEEMGRAIKELGYRRSDLIITSKLFWGVGRKEQNNGGLSRKHIIEGTLESLARLQTDYVDVLFAHRCDVNVPMVEIVRAFNYVIEQGWAFYWATSEWSAEQIEEAHHVATALNLIPPVADQCQHKIKYNYGTTIFSSLYFGLLSGKYNSATVPSDSRFAIEAAKDPEGHFGQIVRSLGEEKGKEMIRKVKEIGKLAESECDLTFLSPSEFLTLPDHMNAGLNTTTPALALAWVTLINPHTSTVIMGVSKPEQLVENLKAVGLLGRLTEKWVFVSVNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE07</accession>
    <name>A0A8H5GE07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE07"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="694" mass="74809" checksum="AC496E9F99F1E780" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILVAWLQATGLSSVLRSDRPDDAEVSTASPLSAEDAAAQSEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLGMTTAKEIWDFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAYGIPTDGTSTTSVTKVANFLIVMFIISKLPPRYEYLINQYTQYTLEEVDTANLDVLQSEIVNIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQQQQQQRPSGSSSGANGASGSNGNNKGKGKGKGKGKAHFRRGGRAGKFEQAKRQGQAHLVNDDMSPMMHTVTVVNTPAAVDTRTKRAINLARDIGARPSGETVATLEDVVMSHPDPSFTSLTPAPRPKRTLTERIYWNNLQSSTDGWGDAGNWNGWNGEYPETQTSLDADMACAQGEDASWNEDTLVNTSELGSVFGTTTTESGAKVSQDIRTPVPLIDRIAADPAAEMMECAIHLGERFQNPEDPLHIYGEPLRTALNTVAPTGTSGTLSLVQRLAAVRNEMPSGSQPAHPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGGMELPSRAPTPSSMPELRSMSPSLSETSDLEYMSTPPSIGRMSLPTSPVEDTASCGIPSPRPTTPVMVTVNAANNYGWSLESEPSGLDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE18</accession>
    <name>A0A8H5GE18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE18"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="268" mass="29167" checksum="7D8A31A33B8B93FD" modified="2022-01-19" version="1">MGTQTVDQERETKTHTEDPSPSLTEPIAQTPSPPVHHSASSPNSTAEWLGKVAQVMSVSPTNTPAPTSTTLPPSDSKTNAVNLSSHYIPVTVSVKTSYSLRQLHVQPWSNPTAKRNRKLAEALGINVSLGNSGGSGFGNVVYNGELVAFGMVNANFWGLWRGLSQTSSRRQRSRNIFTQLLSIGSDWKFDVREIETKRPIHPPHRHTSQYSNPPPYPSTSTSPTCDWDHHSCRTTSSLGKLADPRRESITPSSLAAAASSTSLWKPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GG50</accession>
    <name>A0A8H5GG50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GG50"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="352"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="799" mass="90166" checksum="BB3744C6814DBDE9" modified="2022-01-19" version="1">MNVVGGKYDVRDANGLFPAFKLNTRYTTTGKATPKFSINQPSDSINTLTKKRGPRRGSTRTAASHSSQALVDAILQATAEEPFDIPDNKEVILKILTKLANRVKALERELANCQRKLNHTSSSNSNHSSPPEYGHSAEPPEREGPYASSPAESDEVETDLSTALAHLTIPDIPKQEHFGESSHIMIVLGTMDHRQELASSFESWRRMYSRIQRKPFWENPSWPVRSVSSFPAFEFPDQETLRVLIDVFFTEVNLYDPLLHRPSFEHSLESGLHLRNAAFGALVLIICARASVYANRQYPRGDARSSGWVWYNQIPLDKFVFNEPLSLYHLQLYCLTIKYLQEVEITLRPDMEWLLVGVAIRLAQGRGIHRRSNQKPGPSVEGELWKRAFWFLTTIDMILSEFYGRPRATSIQDFDLDPIIECDDEYWLSEVPSQRFKQPVEKPSMVSFWASYLKLMQINGIAHETIYSIKKPGFGLNVLPPQEVVTELDSALNSWVDSVPAHLRWDSSHQTDVFFSQSALLWSTYYSVQIQVHRRFIPRTGYHVDSSFPSLSICVNAARLCIRVVEVHLRRRSTVAGHRLSAMILAIHLWHGISTKSFQAQILQKEIACIHNCIDLLQCYEPRFLLAGRFIDVLNTVMSASHLAPHLPLNGASSVLSTSAFQTEHPHHQPPSESNLPWSNSGSPGFDIPLYTSDLSVYDSTFLISSSSCLPSTDGGLMDAASVSLSDTGLGPQQFAQYENLKKYTIPPQPLPNADLPQWPTNPSEQDWQEFMMNVDQLFSVPHDPSFGSQSEVHNLFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHN8</accession>
    <name>A0A8H5GHN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHN8"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="331" mass="35271" checksum="3C61B025E49E2589" modified="2022-01-19" version="1">MSMRRLLLPRTQYRLLPQWVRIRGGIHHGEIETVLLSPNGQLEVGFSGNENPNAASFVELQSLPWWNLVKVFEAGDYVTVTGGANKGSGGWVVFATGTGSSGSNRNTRSSSSSSSAPALSSGERGSGVASDVGDVGQDIVEVIEKTMPGSIVSSSGEFSGLKSFSVHSNLLRRVPMPFEFAYTLNTSGPSFSSLRNSNPLTLPGPLSRHVSGAGSLPVSSPETFSAYRGATVIIMDPRCPYRGKRTTVLGVFRGYSSLTRRLWVKIAVEVSDDAGRGLVRMPARRIELDYFGVVDARLVCSPHSTPSGTVSGKWMSGGDSCKEPVVVLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHQ5</accession>
    <name>A0A8H5GHQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHQ5"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="15893" checksum="260A67879485F36A" modified="2022-01-19" version="1">MKFHDPNQLLSGHEFCTAMVKLIEPLSIHSESQPPLICLNVKFLYGRYQKSSLTALCLGAYIVNLTLILHNLFIDMLTQEPPRPVTRELIDDTLQRYKASDIRRVHGLIRAIVDQMLTLHPEEKIADLIRGELGMETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIZ1</accession>
    <name>A0A8H5GIZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIZ1"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="635" mass="70088" checksum="C4B696C71F992BC7" modified="2022-01-19" version="1">MYDEPPSPLITKDPSPQQPPARKLCVRHQRMADEGTNWKLQQSLDALPLADREAVSTIWSTFSSSSHPRRALILQGLLTMCCFSQLSLLTEQLASMIRIDPFVVLPREVSLKVLGYLDATSLCRASQVTKKWKSLADDDILWRGICEQHIGQKCPKCGWGLPVLEKKRAYRASSSPSPDSLSRKRFLEDEYESATPPMKRQKSELLRLPSSSDFSQANSPLVDNDPILSCSILTSKSTSLSGTTRPWKDVYSERMTIERNWRRGRCTVRTLKGHADGVMCLQYSETLTHPAFPILITGSYDRTARVWNLETGVELHCLKGHSRAIRALQFDEVKLITGSMDSTLKVWDWRRGKCVRTLTGHTEGVVCLNFDSNVLASGSVDTTIRVWNLRTGGAFTLRGHCDWVNSVLLWDSNTSSVPSPSSPTSSNVFDIPGCAAPQIDPGKMLFSASDDGTIKLWDLTLRTCVRQFTGHVGQVQSLKLLLSDECDGAASDEPEEGSLTPAKLDSQDEGTPVPSCSKDKVTPSPFPSSSKSKSKNPVLVSGSLDNTLKAWDIETGKTIRTYFGHIEGVWDVTGDKMRLVSGSQDRTIKVWNRDEGRCTATLVGHTASVSCVVLGEDKIISGSDDNTVKVWNFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK23</accession>
    <name>A0A8H5GK23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK23"/>
    <dbReference type="OrthoDB" id="2871083at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="333" mass="37167" checksum="8280AED1854016A9" modified="2022-01-19" version="1">MKRPSTNSLEMWQDLEDLTDVISSMSLPDDQPTSKRATCVPRLYDSRSQAASQKVFKQKKWYNVYTGQTPGCYTTWADTSARTQGVSLARHESFLTYEDALHGWRQNCLAVHAHGQEFVDGSYYENAQEVLPRAFTPPPHAASFKHVPGKKVTSAPSPPPSPSQPRTPSRCRVAHALFGAASPARGTDNILPPVYWAISVNGENTVVTSVDAADAILDEAQLRALVPFVKQVNSVTEAEEWFSHLETPTDESLLQSSMRHNFGHWFLLSNSLLGNKRQRREHGRYHDAADAILDEAQLQALVPFVKRVNSVTEAEEWFSCLETPTDESLQGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK37</accession>
    <name>A0A8H5GK37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK37"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="224" mass="26159" checksum="D7380B1F27CA2C49" modified="2022-01-19" version="1">MLAVTHNQQVPSITLKTELIGKITGRKIDAEALIDSGVEGIIINSRFAQENCLTLLPIKNPFPVCNVDGSENTMGWVHHYTIQKLRIYSQNKRSYHEEIAEFYVMDIRDHDVILGTDWLEEHNPEVDWSFYKVDMVRCPETCILEQFPVLNLHTKPKFPKSTIIDLRTNHKDYQVKWSEPIGRFKLIAQSKWQVDVVEFQFDPFTIPQNLQLFLLKKTLIGRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK63</accession>
    <name>A0A8H5GK63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK63"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="50"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="46802" checksum="258E91C2FFB70348" modified="2022-01-19" version="1">MAEVGQFFVAPVTVTTMKRNAAKALRPKRLVNTYTCRLVDFSENDPTPPYAILSHRWVLGEEVSYQDYLESRPETKKKLGYRKIQYACREARTDGFDYIWIDSICINQGNHDEVARNINGMYSFYQHSEVCYAYLTDVYYKPNDGFADSLVARMWSSGWFQRGWTLQELVAPRNVLFFSAGWEGIGCKRLLKFGISRLTGIPPAVLDGSRPIEDINIQERMTWCAGRQTTRPPDLAYCLMGILGVSMTPDDSEDARMAFKRLQIALVQSYPDRFTEFKGDDIYTMLLSQNMRTRVQSSYNESSMLHCHQHPYPRSQAPASQKVGSPQSGLMNPDIKYAVIAPTSVPPRFTGHPVSQAEIAPSAGILETNDNPLSLPPFSAQTITGSGPVSEHSYLQGPFSDVVLSVIQDTLSQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKG5</accession>
    <name>A0A8H5GKG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKG5"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="316"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5366389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="50706" checksum="656ABD63016FCDD1" modified="2022-01-19" version="1">MSTSTTLPSQTNTQILIVGAGPTGLVTAISLAQHGVSPQDITVVDSLRKGENSSRATVIHAGTLEALDAISSTSVVEILRIGIKGIGEYLTDRHGTPIFKSSFPVLASYTKYPFFVALSQAITERILVERAEELGIVVHRPFKVIGMMRNEEAGGRGRGGGLKVTMESGQVITTNYVIGADGAKSMIRESAEISFGDPNHPGSTAPSDYVHKDLDRMIMADVSFDPPYPSGIAPDIMAMTPSDKGLFLTLPLDSDTGRLYGTEDPVYRIGFTIPSDREAPSYATKECIEEYINRQGPYFMSSDEKLNPSGKSVRIGKVHWSSRFRLRSAVADTFSKRIGDGIVLLVGDAGHIHPPAGGQGMNLGIRDSIGLGKVLAEHVKKFGGDYGRESEEFEVGMKKLEAYAASRRERALKVIGLTKVLVKAATGVVASRLFAWGLGMISMLPLVQKTAAWNMSGLEDKVVDIKDMDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKK1</accession>
    <name>A0A8H5GKK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKK1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="477" mass="51671" checksum="20CBEBBE07D50697" modified="2022-01-19" version="1">MSSNKSGPHPLDPNLAAPGLPVPKPCLSFWQRSTRHSPLLNLNSQQSQDNSVSLPERADVIIIGSGISGALTAYSLLTSPNAPKSVVMLEAREACSGASGRNAGHCRPDAFRGFTAFSKIHGEEQADAILKHEKKVLKLVDEFIKENDVQCDWSLSKTFDVVMGEEFKEYVKTSYERYAGYLKKDVEGVKILGEKDTKEQTRVSSALGGYEWRAASCHPAKLGQALLTMSITKGLQLYTHCPVISVAPSSSDPSSSPSWIVHTPSSQITSPIIIHATNAHAATLIPSLQGKIVPVRAQAHRVIPTPEFCGDRMLTHTYSLRFTLGHFYSLIQRKADGAFILGTSRGIPSISEATKKEIFGAKNDTTYSDEIKDDALARFSEIFGVKPEAMGEGHEYGWTGILGVTPDSVPFIGPIPDSPGQFVIAGFNGHGMARIFGCAPGLANLILGEVKSWEETGMPKCFQITEERLAKMAQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLF2</accession>
    <name>A0A8H5GLF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLF2"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="562" mass="64229" checksum="B27987E9CBE217BC" modified="2022-01-19" version="1">MHHALEIPELLGQIFEYLSANDRKRCVPVCRLFSEIVLDQLWEDVEHERVVDFARLFAPVKKVEDSYMFESESLPTIESWTRFRSKYSKRIRCLHLDYDQYPVSAVLKTISVIRPSFPILPNLHTLKIRCSPRYELMDDVEGFIHDGVQVLSISCFGAVYRMPRWPSCDVWRLHKLASLIQLRFPNLTSLEITIPWKEGLLEKLVTLLGTLPSLKCVSIPSFRNTSDILSTLSSSTDMRSLEFSSILGKPTSRVGNPWLKDRVSSLEHLKIHVAEYRTFFPLLPHLCHLRALHLTIDGITTDCKVLFDHISQCLTLDTLSVHLHPHIAPAVKFDALANICACSNMVSFTFESMLPIDMSDSDIAHVAQSWPRLQQLELGWSCLPSVLDDEFAESGESELEEEVFDSELRRKKTSLWAVFLLSHSCPNLSSLKLFINTKPDRTPSFDDASLPLEFQHSEAANINEARFGFDFDLEAGDEITIAQLLGQLLKPQCILMIDGFEDDIELEDLVGSEALDTSFDSGYEIIQNLRWKTALELFPHFSEPYWTIQELKKQILALQSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLL4</accession>
    <name>A0A8H5GLL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ClpP/crotonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLL4"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30200" checksum="693F96B1CFFF05C4" modified="2022-01-19" version="1">MSYPLSLPAGNPLITLTHPKESLWIIELHNGQDSRLTTELINQGLKPALNTVERDWREGWRRSRKDKNSQEGKGALIIVGRKDQDKFFSNGLDFAKIVDDPNFFPMVFNPLLHRLMTFPLPTIAAINGHCFAGGFLLSLACDYRVMTDGSKRNAWLCMNEVHFGASWPTSFGGILITKFGNGPLQRKIALEGHRFTPQEALNAGLVDYIVQGDTKAVLAKAEEVADQWAGNAKGGVWGLIKGEIYRDALDTIKKEVRVIDANIEDAAARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNK1</accession>
    <name>A0A8H5GNK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CxC6 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNK1"/>
    <dbReference type="OrthoDB" id="2639189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040898">
        <property type="entry name" value="CxC6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18721">
        <property type="entry name" value="CxC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="1">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CxC6 like cysteine cluster associated with KDZ" evidence="2">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="58228" checksum="A84EF4E4278A5B25" modified="2022-01-19" version="1">MSKPAGLPSPAIYGIQTTFFKVYKGIKHCRGYSKHMEAGYILFFGTSILPEPLAPNVLEHEGVLYTRDQGAVAVRIHQITCEGCRVVYHHDYYIVNDPDLGLRMRVYCDMDVAYSGRALPEVIQVATHHFVEVSVALAWRYSMLFSWTSASGCAEAYKACDTYGNVPLSWPISPSLCTEYIYDAFKVISLLEFHHSHSLCLRVPQTIDQAERFNNAMLSMNEYINVQGQLEVNHRCEKCVRRWINETGNEQEIFAVPLSTTKVTFCTTHFAEENRCRVNGCTALVTQGSKTCSNLEHKAAERKYKEVGQSIFQLKRRYGVSDSGWNEGEDMDSGNGIEVEIIQEGQKSKMFYHSEAFSLVAAFCKNTFQSRRKPDHFIYDTNCILSKYVWNPGNSEMCTFFKDIKLAVDVFHFKSKHKEEDEYCGQNCNPVDFPELLYVDQNGKLKWYFNTSIAGQTNAWFGRYQPLCREMGCIFYEFFLNQMIMMYNVEKRKQLERDGYKPSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP45</accession>
    <name>A0A8H5GP45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP45"/>
    <dbReference type="OrthoDB" id="3022400at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62120" checksum="50AF8194599E74B2" modified="2022-01-19" version="1">MTYSSCQDKNQFVLRVDLEPNSNDLEQLRLGVIPTQAQAIQISQFLHDAANDLLELEARVEALRKHMDLKRSLLAPVYRLPDDILVEIFSYEFSHFPVDRTCPNRAFVSVCTRWRRVALSTPTLWATYVIDLSRMQDRYRDGLTNIMALKLYLARSKESLFSISFVDSRNSTSMGYHYTYDHFQEFLLLLVKELHRWKHLAFDNVNSQWQIPDALTRSILTAESFPQLRTFYCSSADVPKSVLAAILKGSPNLNRLKILTLPEPGSTLISANSGITQLQLWAGPCSAIDEVFKAPERCPHLESLFYLLSEVESSEVSFQPQMLYTVRDLTLEVIGNREIVNREHNLLARLMSSFTLPSLKTLTFRSLSYPAFTAYWQCDVFEGFFHRSMCSLTSLRLLSMGITDLDTVSLLQCTPTLVELEISEAPAPSKPFVTIHLLETLHSLDFQASTLIDSSEPLVPKLKSLTLHVRGPHFNDTAFVDMILSRSESRSNGIECLRSVTLRLEGRLMEGKAAYQLRSLGNMMIVTLSDGQVPSPHRHWTASWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPT1</accession>
    <name>A0A8H5GPT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPT1"/>
    <dbReference type="OrthoDB" id="3366475at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17317" checksum="35F192C0CC4480DB" modified="2022-01-19" version="1">MGTTTTTMATSTDPVAPLLQDAPIVIFFTHYLPAILSAISRPALALWHFVTWLIQTTTRPVLLPIPILAFVFAPVIVLGEILFDIFVATPYNVFVYVLDVLYPFYVFCGVACLVGLFIGLVARLAVLYATTLLLGEEAVPAKTRQNESRRSGKERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQW0</accession>
    <name>A0A8H5GQW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQW0"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56909" checksum="A46FCC2D5D4E775D" modified="2022-01-19" version="1">MSSAASQPRPRPRPKPKPKAASGSGNVNVSSDGNGPSPTPVSASTYEIQDSDEMFMRNKTRNRDAWAQLEKLDREKEAKGKRVVSESEDDSDQEKTPQRKSKGKKAEKSALPIWERDKKFKRFLSQDKSDSDDSDDSITILDDNKTPNAKNLKRKRGSRRKQSRSRSITPPPQVSEQQLKIAREQIRKVLGVTRATTSPETEDNEFKLDDSPEKLDPELAAYAQRHAAKAQAHAHRGSSTGPEDKVTIRVKWQPHPNNSSKSATVSEFRLDRSDDFSSLFEAVAEEAEVLPDNVVMTYRGTRVFPSVTPEGRKIWGQADFDACDKSTYEYLRQQEAAARYTQPPPNPKPKLQPKSSSWTKDGDSSDVIVLGSDDEDDDDDDDIQIASPPEQAPAMTPAAPEEDTGDKFKLVLRSGKTSKDITLTVRPTTKCGAIVKAFLKKATLADASEYADFIEGGETSSAKPAAKKPRKSLKKSTTTAEQKTPSLCVDGERVGNDTEIGDQDLEDGDMIEVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQX4</accession>
    <name>A0A8H5GQX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQX4"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="298"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5369377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="634" mass="69504" checksum="4DFD21D689E309D2" modified="2022-01-19" version="1">MDIFTVNRKLLNSNFEGYKLDLVDQDQVISRFPLELGASQSTISSRTLLSFQEVQSKISHNHLAVSPENYAIYVDEAYRVIQISIAPDTLLPSARVVYELPKPIRPSSDEYHPEYPSAAFASQGLLILSDGYGLMYILRCNPDGQFILISTYQLERSNPDRPFLIHSASSVDGNTAVVILSSRSTDSQKDQTASALKASERTPSRVEFDVYGVRFDVSSLNTSENISGMDVLWNRRGDEVPIYTGYNPHSQAFFLIGGSSYRSLQSPPPPSYTPSADEIAPIPRPNEDLDAEKPSYPPKPPPYSWTQTSDSVTVAFPLPSSISKSGIHVKLTSEALSLSVDGDPSAITPLPKYTSKALWDRISPSSSYWTWDKEAEHSFGCLTLHLDKQHEGTKWMQVFASAGTKPASESDPEDVEVPETLDPSEIWHIREALEKYTAALTSGEDASGLGLGKGVPGLAEGEMDEEVDSTVGRMARVSWVGFDGASPSWYQPGREQPIQLLSVPFPGTPSSSLSLIMKEGVDGVVFALGSDTTPKWSHTKSFSALSFVLASKQDVKFTYHTSDLVFAFENGLRDRGGNVYVYQGTTEKWAKQAILRLGDGAGGSLLGVGMVEVQGKRIVIALAEKELITLRVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSY7</accession>
    <name>A0A8H5GSY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
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    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1198"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3184"/>
            <end position="3517"/>
        </location>
    </feature>
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            <begin position="136"/>
            <end position="167"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="685"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        <location>
            <begin position="1604"/>
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            <begin position="1653"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1914"/>
            <end position="2062"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="2262"/>
            <end position="2282"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="2444"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2810"/>
            <end position="2881"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="1266"/>
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            <begin position="1608"/>
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            <begin position="1935"/>
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            <end position="2402"/>
        </location>
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    </feature>
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        <location>
            <begin position="2829"/>
            <end position="2849"/>
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        <location>
            <position position="3497"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF5370666.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="3852" mass="422954" checksum="9F4C3FDBA0F724ED" modified="2022-01-19" version="1">MLSAPTILTNSKLGNFPPIRRNSCLRYSDLSVCCWKTRRTERCTILMILLFTADVDVLILTLQLLLRPSQQYSAQPAVSQALNISTPRLLSLAKRWPHLREYGISLVDLANSQKSSEIDALPAETREVNFSFYRTNTNSSNKAETDVNEPSQSSPRKQSQASNSASSGAVNIHIDEQALQSKPVMNILDEAMSTYNVPDSEKFELLCRIRSAAALRNGHEPEREKLVAVRLLAIAIFGHTHSESQATSSLFLYEPDLITHIAELLQVDRGVPVQVQTAAIAALDALARYRSKIQEALTSVNAGVNHGILMTLLRKTVSDIADPNSSLPNSFAEALLSFVTFIASHASGGNMVVGAGLIPLLIQIIENRIQSRSTVVSKSMQLVDNVLYSFTNAFNLFCSSRGVEALVDRIEFEVDSDIEDHGDETKSLQIYGSQGDLPVARAAVLKHILRSLHRMMQSSGTSEGLRGLIDTSILKSIKKIIEYRGLFGPSVLPIAINIMATFVHNEPTSLTVIQEAGLPETFYKSMELGLEPAIEVIQAIPNAIGALCLNEIGQAQLKARPSIIPAIFSIFTSERHLKVLMEKENAVLIGTAIDELIRHHPMLKTSVFEAMKSTMTKIEELGNAFEPSEDSRKWYKLLSTPAAAETESSMEGVEGTETASAPTALPSPESEPSMPSSATEQGHAPHDNNIVSFIDVFGRFLEGLFQHTHHCRDFISSTDGLTRLGRLTALPGLPYDFANSVASDSMVQVMRTMTEVATSDTLLHLAQLVKESLQLTEEFWRVPEAGSKLLPLVDISKEEEINTNYQFRNLVTLHIRITLLSDVFATAGYAHGRAAIGLLQTLMSHTSPQVVTDLGFLHRASVWENIALKVGLQAQGIQVAQTPSASPLERSPDRPTIDLPGQNGAEAAGASNAPNGATDGSVETPPAATPAKETPAKQQTPREHNATALKHLTHGLPGALAPFFQAMIKMFHARRTPDPAQKKQMLESSGVVADIMHKHLTSRSLEDDDKANVYTYYGVMLGLVTMLLIDERTTTHTLHTVQLLAFYQVNGIDAILSVCRTFITSIESVVKIREEDRSEAQAQELLHAYGGLKIALHLLHPLISAKPLLESGQTNIVVTKDKKDTDPDYFEPHNFLVRLRTAVLPLLRDIWESDWLIHAPLGVSRSVVHAVLEILNGNDETKTDDAGPASSGLMRSSAPDESRIRQLTDMGFPRSAAERALQRTHNNINAATEILLAQPFPFPADPEPESASAADVPSPMEASSGEPSNPAATTATTSEAESSEETQPPGKSAEQWRQELEEAREPFKAGISRKALLLVDEHVSLLFDLHTTFIRPTISHRGQAVQDLVEDIKSFSPYAYDVQEQPLANRCRLMALVLCENPSSLAPELRTSLMDSLLALLLSNPVSIDPNRPTIPRWLAAHLLVTEALFTLSEEPRTVSLSDEEDKIDNGPITVGPPLTEARTIVFDFCLRLLAIPDLPSDDFLSTLRLFVLLTRNPDTAAQFVKRDGLAMLFKRLQMSPVSGSSSYVAIILRHVIEDTKTVQSVMRQSIKRYFASPRTRIIDVASYARNCSAMVLRDASSFIQITQSMCQLLSTSTTSPQISLKADASESKGDDKKPIDMPVDQSSVPQQPSSDTVDAVMSFLISELMRTAKDSEGSSSDTSNQNTGNPNQASGSTDSENIGDSAILAQPRSDDNTKAKGQHMCFLMQCITELLFSYDSCKTAFLSFSPKKRTSTPAKEGNRFRAATLNFLLSDLVSFEGINPPNTTETRTKMTVCSWAMSVLVALCVDTSTAHDSKEVSSDLVAVRKYVLESVSRAIKDLPSESIERRYGRLLALGDLCHRLLTVKFNSNPRKHQEDSPTQIAKAMLEKNFVATLTNALSDVDLNYPNVKTLVAAILRPLEYLSKVAIKMSKGPGKGKDSTMEQRPESDISMSDEEDDIEVEDDREETPDLYRNSALGMYGGEMDDVNFNPEDEEMEGDEDMDEDDEEMDFGEETGSEDTSASDEEEDEAEIEDEHEQPEVWGEEDEEEEEDMVGEGQEEENDEEDEGTDDQGEEADEAEGDMMWQDVHGDMDPEEIADEVDEDDGGGPIQIIHEEDEEEPDMVSEDDFAQELDIVESGEIVRDIFGFGDNSALNTGFFVNRGHRGADDAIPFFGRTRNGPVPPVEATTHPLLLDASVSGIRGGNNPLRGSRQPQRIVTGTNELLQTIEELVGGGAIQFFQHIMTRGRGGGGPETIRLDVPATTFMDLGRGYLQRRPGLTASVRMERNPRASTSNSQARALDPLLTLPRWAEEVKILHGDFVNERAVKLVNHVVIALLPAAREAARLAKVKEEQEAAAKAKAEAEAEAEAKAPEEAEAKAREEAAPQVPPAVPADDNVAAPATSSTEDQPMEDISTSVDADTEMIDGTSVTPADQPAETDQEEPSPSTAETPSSSTAETSAPARVTVIIHGSAVDITDTGIDPTFLEALPDDMREEVVNQHVRDQRAARVERPPDSQISAEFLDALPPEIRAEIIQQEAMERARRSTEEAQAALGDAAPRAPADIDPASFIASLDPGLRQAVLMDQDDGFIQSLPSHMIAEAGAYRDGTRRIHIGSRGVRPVTSSNAPRKAATAHDAIQLLDKAGIAVLVLRKNLLFRVLVNLCENAKTRTELFNLLLSILQDGTGDLTAVDKSFSQMSFRNSKPSKTPGKQKSGSDLINTLALPQGQIEAVPDLIAQRCLEALTYIVTSNPTSSLFFLTEHELPVGLRRAASKKGKGKERQMPQTHYPIVLLLGLLDRQSLLRTPSIMESVVGLLATVTRPIKEAKMQARTQVDTSKTATDEATEATGASAESTSGDAQGTAAQAPQPPPTASAPEEPENSTSQGQKAVASPKDRDTSIQAVEQQMLLANPPQIPHAVLRLIVNILTVGECSARSFQQSLNLIQHLSYIPDARDVIAQELKAKAQEFGHVLQSELDELANALRGSETQLSTVASKFSAPSSVQAQLLRVLKTIDYMYTPRPSAGSANTDEEDTEKVQAIYESFQFSRLWKRLGDCLAIIEDKPDTEHVATVLLPLIESLMVVCKYVGSKASSAARLLRATASPKIPTTPRESMEDLFVTFTDAHRKVLNVMVRNNPSLMSGSFSLLVHNPRVLDFDNKRNYFTQQLHRRPHAREHHGTIQLNVRRARVFEDSYQQFQRRTGDQIKYGKLSIRFYEEEGVDAGGLTREWFQILARQMFDPNNALFQPCAADKLTYQPNKNSWVNPEHLSFFKFVGRVIGKAIYDGRLLDAYFARSLYRQLLGKPVDYKDVEWVDPEYYNSLCWILENDPTPLELTFSVEADEFGVNRIVPLKENGESVPITEENKREFVQLSAQYRLYSSIKEQIEHLSAGFYEIIPKDLITIDMSVVADVCSQFNEQELELLISGTPDIDVDEWRAATEYNGYTSSDPNIVWWWRALKSFNRDERAKVLSFATGTSRVPLSGFVDLQGVQGVQRFSIHKAYGEPDRLPQAHTCFNQIDLPQYSSYEMLRQQLLNEMRGIVVKELVHHSQVKLATDAPIPKPGKNEVLCDVYSAAMNFFDVLQTQGKYQNKPPLPFVLGCEFAGRIANDSPIPPGCRFKPGDRVFGAGQGSYAEKMVVNVESLLPIPNGLSYEQAAGLYITWPTSYEGLVGRADLKPGDVVLVTAAAGGVGIAAVQLAKALGAKVVAAAGSAAKLDIAKRCGADFTVDYNKAGWQKDVLQWNKGKGVDIVYDPVGMITDCLKCIAWKGRAVVVGFAAGNIEKVPMNLVLLKNVSIVGLHWGAYRLNEPNRTPEVWKNLLDLLSSGKVSPVVYSKVYTLETVTEGLTALEKRETWGKVVVSVQGDTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT73</accession>
    <name>A0A8H5GT73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_002046</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT73"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5370601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="597" mass="66885" checksum="993181BB6A0B2E64" modified="2022-01-19" version="1">MNSRFATQTRFAALAVESSGEESEEEVSDVQDVPLTTKMDDTPPPPKLSKTASKKAAKAARLEKLKKQPDAVQKKQPPVAENHISTSDVAPFPEPVQAPEIPAQNPFETANAAPDVPAEPVVEFATVVSDAPQDAPHISEVPHSPPELFVSLQREVSPQNSNHVDHVDESTKEQQTMHSTEKTEPEQPLQSNTVTPSSDAELAKKRQNIFTRTLWTFIMIFGFIGLLLMGHAYLILLVMLCQTLVYREVTALFSLRTSDSKTADKNGKDPWSKTLNWYFFAATNYFLYGESIIYYFKHVVFSDSQLLPFATNHRIISFTLYTFGFMGFVMSLKRGYLKHQFGLFCWVHMSLLLIVVSSHFIVNNILEGLIWFFVPASLVICNDVFAYVWGMSIGRTPLIKLSPKKTVEGFVGAFGSTVLFSLLWGTYFMRFKYMICPVHDLGVSAWSSVDCAPNPVFVWREWQIWSPVVTVLSNALGRQITTIPYVPYHVHLLLLSCFASLVAPFGGFFASGFKRAFNIKDFGHSIPGHGGMTDRMDCQFLMGVFTYVYYSSIIRQHHVTVGSVLQTIVSGLTVEEQLELIADLRRYLEGSGVQIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU72</accession>
    <name>A0A8H5GU72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_004202</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="766"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1069"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="608"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1602"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1326"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1617"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1627"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5371313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1649" mass="185280" checksum="718D7A2BE74FD9DF" modified="2022-01-19" version="1">MATEAGESQPLLHTRSQQSSPYRWARGWKPNPYWLIPVAMVMNVSRGMTMAMRVQVYTDIACASLGLPNGQCAEAPEVQARAARIQASVTTIMSILSAIATGPWSRWGDIHGRTPLLMLTVFGALAMEVAFLLVTRENSVFSRYAEQFIMVGPVIDGFVGGLSAFNGAVHAYISDCTPHGSRARIFSTIQGLVFIGLATGPWITGFILSFGNFSPYVAFYASSLVLILLLAYIAMICPESLTKEKRLKTDSGEAEIEGRRPTLIANLKSSLSSFMAGFVSPVSMFKPRDDPHLSSVGKDWNVTLAGGALFLYCISVAVYNIKYLYGKHVYQWNATQLGFYMSLLWATRAVNLLVLLPIIIGYFKPKVLPGEAPDIYAEMRFDQILAGASLVIDGTADALIALIPGASQNIFVALSCLSSFTSGGNPTLHSLAAVCLHAAGYSSEVGSLFGALAVVAAAAHVISPTLFAATYSSTVATFPQAIFVLAAALLFTAVLLLALIRILQDYYFGKIASILETIRDPLSNDAFADVGETAQLFVESFAFGNCNASCVSHGHTSSPPTTMSTFTVANPDDDILSDFVPSNIVSRQVGTRLFTEFFVGLNDDLSLCTQPSEPSEGESEFDAEEDDELMDEEEEEEEVGKEKPKKQTAAERAAKKEKRKAAETELLAKRQEMDKNKIADAVKRYSYLLGQTELFKHFVDIKRAKDPQYAALMDAQPKPKGRGRKKAADNSARHRKSEKEEDEELLKDVIHGNMRPYQLQGLNWMVSLHHNGLNGILADEMGLGKTLQTISFLAYLKHYRDIKGPHLIVVPKSTLQNWAREFEKWTPDFKIVLLTGSKEERQQIIANDLITQDFEVCITSYEICLIEKSTFKKFSFEYIVIDEAHRIKNVNSILSQIVRAFMSRGRMLITGTPLQNNLEELFALLNFICPEIFVDYSDLNTFLNKDSNSDLSDEEKSAKVVEALHKILRPFLLRRVKADVEKNLLPKKEINIYVGLTEMQKKWYRSVLEKDIDAVNGLTGKKEGKTRLMNMVMQLRKVTCHPYLFDGAEPGPPYTTDEHLIENCGKMIILDKLLKSMSAKGSRVLIFSQMSRVLDILEDYCLFRQYKYCRIDGGTAHDDRIVAIDEYNKPGSEKFIFLLTTRAGGLGINLTTADIVVLYDSDWNPQADLQAMDRAHRIGQTKQVYVFRFITEGSVEERMLERAAQKLRLDQLVIQQGRQQQTKAANKDELLEMITHGAEKIISSSDLLIDGDIDEIITRGEERTAELNSKYEGLNLEDLSNFKSDASVQQWEGEDFRSGRKALNFNLLSLSKRERKSNYSVDNYFKDTLRQGPSKPDKGPKLPKAPKQVNIQDFQFFPPELAALQERELAVHKRLNGITATLRDPGPDDTPESLEEERAAAQELIDTAEPLTEEEQALKDQYIESGFPDWSRRDFQQLVKGLEAYGWNQPPEVYATDIQEKTAEEVRKYYETFKQKWTTLSEYPRIATRIAEGEAKRNKRDNLESLLDAKINSVRYPMQELELNYPTTKGKVYSEEEDRYLLCRLFHYGMQADDVYERIKKDISEFPVFRFDWFFKSRSPQELQRRCNTLLSMIEKEAELKKEEEMKAKGGQKSKKRGIEEVKAETRPSTPTGSTSSSAAKRPAKKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWK4</accession>
    <name>A0A8H5GWK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWK4"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="179" mass="19353" checksum="B5BCB6253FD1C1C8" modified="2022-01-19" version="1">MSTVPELTGPNYTVWASKSKSWLQSQGISYVLNTLCPGTVTITDTGTQTAPADPATPAAGSDDGSGDTAPLTHFFTITGGEAIDWDKDNDKAMGVIKLCVTQAIGLKLNDIDTAREMWTLLKDLYGKPGAAEVFQNFKWAMNVKIPRNTHPGTAIDLIKMYLTQINNAGKNTLIPMYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX06</accession>
    <name>A0A8H5GX06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Copper radical oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX06"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034567460" description="Copper radical oxidase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="453"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="63350" checksum="5BA10299914699EF" modified="2022-01-19" version="1">MNLSFTFRSLLTCVLVGSIAAQAQYAPGQWSLVQDGNSGVSALELAVVSETTVLIFDKAEHNPLQTNGHVAWAAELNLVTRTVRPLNPTSNTWCATGSFLSNGTMVSSGGNAVFPVATGDNGLASIRLFDPCEDGNCDVFEDQRVRRMGSLRWYPSSARLEDGSVLLFGGSWDFWAIDNSTIINPTYEFYPPKNIHGHNGTPIYSPFLQDTLNANHFPLVITLPDGNLFIAANTQAMIFDWKTNEQVRNLPGIPNGVRISSPFSAGATLLPLTLENNYTPEVLICGGSTLDDDAELFTPGIPSSQSPTSDQCVRMVLNDEGIAAGWQVEHMPEPRIMAELILLPDGRVTIVNGAQTGIAGNGFTKDQIGESDCDHPALTPAIYDPTAPLGKRFTQEGLPTSEIPRLYHSTSSLTPNGSILLAGSNPNNDVETHLYPTEYRLEWLSPPYMEKPRPTYTGLPKTFDYNSKITLDVDLPPGAENVSVVIMDLGFATHGVHMGQRLVGLVSELSHHKTKLTIAGPPSPTIYSPGPAFVFVLADGVPSFGSKTLIGTGAQPPLDEDALANVLSSQPLYWDKWTAAHPGAPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYN0</accession>
    <name>A0A8H5GYN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYN0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="12544" checksum="55CD070C22E706B7" modified="2022-01-19" version="1">MPKTQPFSTRLSHRYHPYRRVLHSHLQSVTPKVDIQLEREQQMEIIVIPLVDETIEIEVDDIRWRMRLSDHILNINSFPVVVDQKFFLHPRRWTLAYPTDKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHN3</accession>
    <name>A0A8H5LHN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHN3"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="197" mass="22172" checksum="FD8FC3DE91697F16" modified="2022-01-19" version="1">MGTLSPSHRLDYSMSAPPVDTPPNESWWTPGKIVSLYSWGHLVPQIFANQLRTKKEGGKGLDIRPSTAVTSAHIKLSELDGTARRGEIDVDGNIVTKSRLVKREDESVNKSIDPGWTLLSKTLLRHSLFEETDGMYPKLDPTSKPLFTQSVTCRLRLRSPCCTRLLFIRRTRYSRSPRRIQYDGAGRSGDMIKDGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMZ1</accession>
    <name>A0A8H5LMZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMZ1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31149" checksum="6D283450295A0340" modified="2022-01-19" version="1">MSSRSSFMSTVPELTGPNYTLWASKSKSWLQSQGITYVLNTLKPGEIQIIGSTSPVPAPPAAPTGTTGGTTAAAAADEEESDAGSGVPSPHFIAAASGSVADWEKDNNKAMGVIKLHVTQAIGAKIKNITTARVMWDTLKDLYGRPGAAEIFQNFKRAMNVEIPHNAHPGAAIDLIKMYLTRITNAGDNTEIPMYLQYMIVINKLPPDIYAYIIAKITQDDIDNFEHETLDNLRTHVINTWEACGGKKPQSANATKITAIKCKGKPPVFEEQQQQRHKGGSSAWRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPR5</accession>
    <name>A0A8H5LPR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPR5"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034031273" evidence="2">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="34429" checksum="F997E182069FC492" modified="2022-01-19" version="1">MHLMISLLSTGCTVIGDASSDGIGVSRHVTGPTIVNNDLFQALRGGGNNFGIFTKFTLKTFAQNDIMFGSYVLISGTRQEKFKNALVHFVENEERPEACLAAAFRHELVRGKVDPEYSISIFCVFDVKKPKKKCNVPFKALVRLQESGDAYAADPAGWQLGKTSLALSALELKTSSLNSKMLASLPGTPQPKDDGRRKRSEDSDAKGPTGYFQEMSWSDMYEVLDNSSDTDSDDDDDDGGRDSKGNMGDSSGDDDSEEDSEDDSTVKKSKARKTNKNSKQMKKKFEDDDDIEAKANKMSKNGRQRSWAAIRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPS5</accession>
    <name>A0A8H5LPS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPS5"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5364959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="423" mass="47088" checksum="27E6B4D4326351CD" modified="2022-01-19" version="1">MHYLDNGSDDQDFGLKRANTISHRGFHTPDPFAPRQRPGASFVSALLATALFRCWHILIFFGAWATLITILNEQGHKLTFQPTLLTVIGTVLGFVISYRTTSSFERYNEGRRLWSQIILATRTFSRTVWFHVPDPPATATDSAEVLKARAMIEKKTVINLLEAFSVAVKHYLRGEDGIFYEDLYYLVKFLPAYALPTGIPSHPDLTRSFDAHGAPLAPVASPGSLKSIPESPETRTTGSTGGTFLHQRTNGGASQAPAEQELPAPVTAPKPRKNASFSLPKLFKDEKEKEKDDPPLSPAEEKRPERVILRREDESFLLPARDAPKYGIFDLFPFSLLVKALTRRGRELKGKKAARLRAKMRNVGVSHNLPLEISLYLSSYISALQVRKTNEVPTTNTLLLALNQLVDGLTGLERILTTPIPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQC3</accession>
    <name>A0A8H5LQC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQC3"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="50927" checksum="2FA50323C2C5A9A8" modified="2022-01-19" version="1">MSDNCLLGALFYGGAGLARCPHRNTVTSMTTCDTLSGYLFLLFLLSVTFDTMSVFLSASPSKRYITLVIVLVIGLHYLFSITYDSYGVSSLSGLSDQFLSSNTTDRVLDVDDIDVRYYSNYTERRANATFVLLCRNSDLNGVINSMQSAEDRFNRRYNYPWVLLNEEPFTEQFMHRVSLITRAPVHFGLIPRDHWFQPEWIDENKARAGRQKMMAQRIIYAGSVPYRNMCRFNSGFFFHHELLQPYRYYWRVEPDVRFFCDLEYDPFLYMQEHDKVYSFTISLPEWEPTIPTLWATVKEFMGLHPEYIQSHNAMDFLSNDGGNTYNLCHFWSNFEIADMDFWRSEAYQAFFDFLESKGGFYYERWGDAPVHSIAAALFARRDQIHFFRDIGYRHDPFQHCPSGEQFDAGHCACDPKDTFDYHQNSCLPKFEALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQM6</accession>
    <name>A0A8H5LQM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQM6"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="443" mass="49901" checksum="D261AD50FC8DAD39" modified="2022-01-19" version="1">MAHTSPATYLVWSTMSVLLGAFLVYHLWSFDRFKCLKWNNGPYSGAFKRVMTYTYLLNLPCIMAYSIGFAIIKYTEGFVAVPSTGLVVPKPFTEWRESSHNAIFPLTLLFAMSNAFELVTHLEELCFWHFLVNASSEDWFRSKYFKIWVGGSVVALIYMPLAVILTRHELLRCEAVAFFAGSLGSFILTVAFLPVLFKFPSFLANLKREGVETATVIRLTKFHELNTIRICFRFLFNCPVLILGIDGVRPHVHSINENMLWTDLLAIVAAIGCVVSSAITLVIFFPRDIGSEIANREIVKERKRQASSDWRSSRTDQSVMSETRPHRYSLTSSLPPHDGSPFNDRYAARPSPITPLQEDKAWVAQDEIAVEPMHKIAPIRPNRKRGDDVELGGIGPLSSGNPALHNRTSGIVINRAVFTYTSPIDLAYAGNTTSDTRFTFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQW9</accession>
    <name>A0A8H5LQW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQW9"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="781" mass="84120" checksum="C1B76F582D4585B2" modified="2022-01-19" version="1">MLGCFKSSSVRNCERFSTSEVGRVEYRPKVAMQQGEERWRLDRRRMVHRGSSRKPEVPPDSLYIANGWKVVDIVKHSHPPLFLHEIIRMSTESPLPVLLPSNSLPREPGIPHVEWKPKCFQNPPQPPPTDDTKIQEQELAYARQFMDGKLVKKTRPRRTVDYNGGLGRWNMLRKLRPNPYYLPQPRPCPPSVIDLLPPKAYTDNPSTSLCTKFVHTSTNKIRCPVNVVTWTPEGRRVLTGSTSGEFTLWNGLTFNFETILQAHDTAICTLTFTHSGAYLASADKAGIIKYFEPNMNNLTAWQGSSSREAIRGISFSPDDKRFATASDDSSVRIWSFAESRVESVLTGRSFGCLLKAVAEDFLAGHGWDVKCVQWHPTKGLLVSGSKDNQIKFWDPRIGTCLSTLYHHKNTVQAIAWSPNGNFVASASRDQTVRVFDIRMLKEYRILKGHKKEVCSVTWHPTQPILVSGGSEGSIIHWDLSVEEAPQSFAPSLPSSVMTSKSSPLSTTVPDYLSLSQTPTSTPRATLSQAHDSNVWSLAFHPLGHLLVSASNDHTTRFWSRERPGDPDSVFGAGGEKLPGASGYKNYDGGDGGEDGYGWDGQGEGDEDEMVPGIGGGGFVGSLPGFLGASASAGAGSASGQGWQDDEGYSGTGTGNGNGNGNGNGNGYNGMGDGHDSGTGGNTGGGYGYGQTQTQTQGGDDDFIPGFGGGGSSSGPPQDDGYTPGSGSGSGYGPGSGRNGYGGGGGYGGGHGGDDRGSGGRGGDRDRDRDRPRRGRRGRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRS6</accession>
    <name>A0A8H5LRS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRS6"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="449" mass="51030" checksum="B3A09A7C346DEF3C" modified="2022-01-19" version="1">MAPSALDIEEEQRHFSNVISTFQNYASYSLAASNRRRKDLFTLPQADQELLSSLGYKEKLEEVDKAIITNAEFLKQVVADPEIFGHDVDDGDDEETGEGEQVEGRNLSSQSQEHQHTHNHDGPDQSHSRSHSHHNHHSGGHDQNHGHSHDHGGRRQKRYKPTEFDMDKLRSTLKQLVRDWSEEGAEERKTSYEPMKEALLAHFSDIPREERRNFRVLVPGAGLGRLAYDVANLGFACQGNEFSHYMLLTSFLILNRSEEVKIHTIYPYVHSFSNVPTRASMLRAISIPDVLPNLPAGSNFSLVAGDFEEIYGGKADPDEPQSGLWDAVMTCFFIDTAKNIVNYLRIIHRILAPGGVWINLGPLLWHWENNNTNDPSVELDLAEVKELARKIGFELKVDRFTLLPSKFSSDKDFDIYQNEKTIDATYTTNSEGMLGYTYRTAFWTATKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT29</accession>
    <name>A0A8H5LT29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT29"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="128" mass="13600" checksum="462617E84931B0E2" modified="2022-01-19" version="1">MSPPHSRDNKRKPSLINTTFEALTSFALARDDLSPTSKPSSSPASPTVMSFTSNATSGDAAASDGYFTSFREKQTRSRPCSTSVSSLDRERCTSAWGSFSSAAWCSTPGDAAVVLIASNIQSGMQQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTK2</accession>
    <name>A0A8H5LTK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTK2"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034214776" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="38"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="34230" checksum="6CFA7507E973FDA7" modified="2022-01-19" version="1">MATRLASILCLALGLRQVLGATYSQTSSISGSQFLSAFTWQAITDPTHGRVRYVDQASALNQNLTFVSGDHFVIQPDFTNTLDPNGAGRDSNRIQSNQAYETAVMIFNIRHMPQGCGTWPAVWTVGADWPNNGEVDILEGVNDQGSNTATLHTSSGCSMPASRSMTGTALQNNCNVAVNSNAGCGVRLSDTRSYGPTFNANGGGWYAMERRNTGIKVWFWSRNDGSVPAEVKNGATSINTSNWGTPAAFFPDDSCDISSHFGPNNIVIDLTFCGDFAGNSAIYAQSGCPSTCVDFVNNNPSAFRNAYFDFQWLKIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTM2</accession>
    <name>A0A8H5LTM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTM2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="229" mass="24740" checksum="D42A83EADF3700F1" modified="2022-01-19" version="1">MSCFVCNLVLQVVVVFFGDLGHSFGVFFSPLRVEVSGVVLSRCGLIYFIHCALSSGYSGGHVNTVESRLALRALSGSALAGIRSIAPASTILKSPATISGLRKLLLASPSRSVTFGASWNYFNYLDVVLIGTRVPFMEDDSHTCYTCWFVWDPVLSTPFSSVLMGRQWGVYSILDWILTIVVLGPSFMLVGLVGGGFLGLWVIIMVPPITVNSEVCSVNSVSINLLIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTY5</accession>
    <name>A0A8H5LTY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTY5"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="151" mass="17033" checksum="A4A98B69945DF3A5" modified="2022-01-19" version="1">MHFPKSGTAWPVLRNRLVFSPSMSSSSTARLRREEDVKRAGEIQAEAAIIGGLRMGAIGLGLEIILHHTWPAFRRQRLPFKAYLLSGFIMTGLVFGAEGALLKHEAQRRQEENMLRRQARLELSQRGIIPTETEITRWMTERSSQSDSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU54</accession>
    <name>A0A8H5LU54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU54"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36603" checksum="05F8ED6139EEF296" modified="2022-01-19" version="1">MRPYAIHSPCTSVLQKLRISPVSWRQGPILLRHYSSTGAAADPIEHCRSLVQKHDYEGYLVSPFFPKHLQGGYFALKAFYVELAMIQDSVSNPTIGMMRMQFWRDAVKAISDGKSPPRHPIAHALYEASQTSHLPAYHLKRIIDARDAELQAPGHLTIDSLTAHAESTSSTLLYLLLSMLSLPSSTLSHAASHLGAAQTFTTLLRALPFHAQKGRIVIPAEITAKHGVVQEEVFRQGPSAARLDDAIFEFATLANDHLATARSMFGQEGLGGRVPVEAMSVFLAGVPVSSILKRLEDVNFDVFNRKVQTRDWRLPWWIWKSYYKRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUD0</accession>
    <name>A0A8H5LUD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">D9758_001253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUD0"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="145"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="660"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5369833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="748" mass="85184" checksum="1DA562B9A8E8021B" modified="2022-01-19" version="1">MPVQVKNTKKRKQNEEEDALPGPFSKAVDMEMLSDEEGPDGEESDGQEVDEFPEIDAESDEEDSEYEGFEDDEDEEEEDEDDDEESESDSDKEDPLHVFPKAKTVISDITGQPKRVFPEIEPEYDSDSSTEDAPNRVGNIPMHWYDDMPHVGYDMEGKRVLRPARGDELDKFLETVEDPSAWTSAFDKNTQSDKPLTTEELDLIRRLYAGENPDGSYDPYEPMTEWFTGKGKEEVMPLSAAPEPKRRWVPSKWEKKKVMKIVRAIRQGRILPSKPKSTAQPQFYSIWAEPSSSHPPPLPAPKPPLPTNSESYNPPEEYLLSDAEQKQWEETDPEDRDRDFIPQKYSSLRLVPGYDRFIKERFNRQLDLYMAPRVQRVKLNIDPESLIPKLPSPSSLKPFPTYRSLRFQHSTLARCVAISPDGAWVVSGDENGIVSLWELSVGKEIKKWKFEGKVGALEWCPRTDVSFFVVGIEETLHFIIPPYLAPAVHQLTQTLLAPTTLPPALDTSSPIKWTTPSSSTWTDDTPLLSIHLPSGSGLPTQITWHRRGDYMATVSSGNQGGVWIHQLSRRYSQAPFKKVRGKVQLVLFHPMKPHFFVATQQYVRIYNLSEQKLLKTLTPGIKWISSLDVHPSGDHLIVGGYDRKLCWFDLELSDKPYKVLRYHSRAIRSLHFHPTYPLFASSSDDGVIQIFHARVYSDLMTDPLIVPLKVLRGHEITQGLGVLQVRWCSKHPWLASSGADGTVNVWCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUI4</accession>
    <name>A0A8H5LUI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUI4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="90" mass="9667" checksum="423C2E6432F08705" modified="2022-01-19" version="1">MSTTTSPRPPTAEITSSMCPRTPEVTEVIEVITVLQLYSLRMWFLLPLVTSSMRTGVVTIVTIVHIAVVVMVTAVIGGCLSLNVFVGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUS9</accession>
    <name>A0A8H5LUS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUS9"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="500" mass="56390" checksum="B452CFCFE4995BB3" modified="2022-01-19" version="1">MHLFKYPRRRFRRRRVPSSASLRNSASLPLSPTAIEIKKLINTEADGSARKAFENEMNSFLKLLSRYLEQKSRPPSLDWSTIKALAPDQVIPYEELTESASIDSLKKLAILKLNGGLGTTMGMQGGTKAALEVHNGLTFLDMTMQQVLHVNSTHNVDVPLLFMTSFSTYDETLRITRKYANQPIKVTLFNQSRYPQVAENTYLPCPKNTNEGKTWYPPGHGDLYTALDRSGVLDALLSQGKEYVFVSNSDNLGATVDEKILQHMITCKSDFLIEVTNKTNKDDTGGSVVDYDGVVRLVELEQVPPEHVQDFMSAKHFKSFNTNSMWISLKAIKRIIGKGELELEIFEKRVSGENERAYIQLETAAASAVKYFEKPKVINVSRSRFLPVKTCSDLLLIRSDVYQIQNGCLVLNDNRLFQSPTIKLSDQFRSVDQFQRRFKTVPSMVDLDLLTVTGDVHFGRNVTLRGIIIVAAEEGRRIDIPDGCILENRLVTGNLNMIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV87</accession>
    <name>A0A8H5LV87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV87"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="377" mass="40698" checksum="5DD07B668CA9E568" modified="2022-01-19" version="1">MSDQLKTVDQLTITFLVDNCIEWFTKLPPGFTHELPQHLRFHHPEIDEVTNTPVLDFDKFCCGAHGFSALIQTTISDEPSASASHLVLFDTGPDTQSLIRNLSAMQIPVENINRVITSHWHSDHTGGLLSFLKLRNGDNESASTSPSAPPPVPPCACIVDVHPDQPIARGIAPGPTYDKVVCRLPPDPRFEQIEQAGGVVEKHSEGHTVANGSVYVSGEIPRVTPYEAGLPGAMRWKVGEDGKGSWVPETHIMDERYAAIDVAGKGLVLFSACSHAGIVNVVKDAVSKFARPVYMVIGGLHLAGADFSPRIGPTVKFLSEELKPAVCYVLPMHCSGFEAKVALQQAFGEGCVPAGVGLKVDVVGDREQDKRLLAAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVN3</accession>
    <name>A0A8H5LVN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVN3"/>
    <dbReference type="OrthoDB" id="439046at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31807">
        <property type="entry name" value="AUGMIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31807:SF27">
        <property type="entry name" value="QWRF MOTIF-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="821" mass="87974" checksum="4446F36901205858" modified="2022-01-19" version="1">MHYLAPVGGEPYPLVGKSKQSNNTVLETEQSYSTAPALTHDREVLTSLFTNHHDDPKHLTLILEHFLTRYPLPYFLVHLASLRTEMQADALALEMYREAQYILYTQGIKDAVLDKVIEEYTPVVKKKAEEGLISGTTGPFYQPYLPTRSHKFPLILPHPPPQHSEIQDEWLRKCRCWCRCHFRDPEAGRFEDMYVRKMAIDTNQLEGVFLLEGESAKSIIQHGLPPSRSCSSQPKPNDNTNTIHLAPESPIQDPELTRGILEDTIEAFRLLIPLAKDGIPSSPSPSRSHSRSRSRLSSPSPSPSPSRSRSPGSRSPSRLSPPPSSSYPYPSDTNTNAANPNTNMDGNGTLKVDADADTDADVDAETQTLTPEAVCRIHERLTRTMRFIPVPANSSSSSSVSSSSSTSSSRSTSSGRSASGNSSGSGSAPSSAASSVPHTPLPLPLLLSTAFLSSYFASPYGSDTESTEKEKDEVKEAKEAKEANSEPEFNFKPLDKGSGGDGYGGDSSFPSNAHAHSHSHSRSLHSSQRYIDTSPGHTRSQTLKSGTVVVVEPFTSTSSSTSSGTVSASGAVSRSASPYPAGSASLASSLSAGMGGFGPGRGSGTTTTTTTTWGDGSSLVGVPDNANGSAKRGGKGTGTYTYTLQSCPYPSVDSELEYICLMGRQFIKTWWRNPFGTASWLHLVLVRLGGFEIGNGPLARLIASIPLIRYGYPPIVIPIPCGSSSVSSSQSSAPAGSESGSKSGDGDASTSTSPSPSKEKKCSTGGSLDLRKEYYSAINDSWNGDHKNFISCILHGMRGVLDELDLDFEAQPHEVCDCDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXE7</accession>
    <name>A0A8H5LXE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXE7"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016559">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="7">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="6">
        <location>
            <begin position="618"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5373117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="704" mass="77606" checksum="CFA51FFB3BEB38EE" modified="2022-01-19" version="1">MSTVGPTGLGSEIVTLINRLQDVFAAVGSSASQIDLPQICVLGSQSSGKSSVLENIVGRDFLPRGQGIVTRRPLVLQLIHREATSTSKSPKDSTDPNSNPDEWGEFLHLPGQKFYDFNKIRDEIVRDTEAKTGKNAGISPLPINLRIFSPKVLTLTLVDLPGLTKVPVGDQPKDIEKQIREMLMKYISKPACIILAVSPANVDLANSDGLKMAREVDPEGTRTIGVLTKIDLMDAGTDVVDILAGRIIPLRLGYVPVVNRGQRDIDSSKAISQALEAEREFFENHPSYKGKAQYCGTPFLTRKLNMILMHHIRATLPDIKARITSQLQKYNAELMQLGGPHAEANSGNIVLTVITEFTNEFRTVIDGNTNDLSLNELSGGARISFVFHELFNNGVKNIDPFDQVKDGDIRTILYNSSGSTPALFVGTAAFEVIVKQQIKRLEDPGLRCCQLVYDELIRILGQLLNKIQAFKRYPALRERFNAVVVSFFKNAMNPTTKLVSDMVAMQACYVNTTHPDFINGHKALSLVQDRLNANKPPPPANDPKSGKLAPGVINNNKDLDVEAKKEEASFFGSFFSSAKNGRPVKKATPGGTPASTMEAPPAVIKPQAALSERETMETEVIKLLIHSYFNIVKREMIDMVPKAITFTLVNHSKENLQRELLQELYKAEVLDDLLKESEYVVNRRKEVIGMVQALNKAEEIVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXV8</accession>
    <name>A0A8H5LXV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXV8"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="301" mass="34357" checksum="5290F22C500BE349" modified="2022-01-19" version="1">MSSISQGPEAQDSLFELPPEEQVPDNLVRATHRLQFPPSYVVVGVYRLFTDKALFVPAWQKCKNGTIRGTVVGLVWTFFTFGLQRRFIGVFLANSPRVTGLSNETLFGYKIPFSVNTYAAVLLVGSQVTYILRFFLARNINIARDRVWDQTVASRGKGPDFWKPYVEEWDHPPKVPPPTWSDKLLQSSFGMMVIKRILLLPFNFYPLIGIVVSAWFKGLGTARALHRRYFESKKMTAGQTDVFMEEHKWEYRTFGFTAALLEGLPIIGLIFNISNRVGAAMWAHDLEKRQHYIALKKAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYZ3</accession>
    <name>A0A8H5LYZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="596"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1326" mass="148619" checksum="FEAE5C220FE57AEE" modified="2022-01-19" version="1">MLSLLESLHGSPKHPLKFLGHLLLYPEADSIVILDAHTLALVRVLAFWQAFPGLAHISDSISCISVDAGMKHIVAAMGSKIASWSLSGIQNDSWLVHSSLTLDRNVTTMDSCSGLLAVGLDRGLSVYTLILENDLPTWSRKWTMSSKYSPRLVRFAPSLMYIAATTDIDNTVRLHSTTSGRQTQVLPHPRPVINLSWRLSETSNRDDLILYTITADSVILLNTCKLHASIDLRSSVSYPIADQKDKPTSSVFWMDRQVLNHCLQHLLAQKSAEDNASLRRLQDVKEEGWDLFLRVLSDGTIVISAVANIDRRPPTLLRQFTFQQFSGPALTSPPSYLYLVPNNQTGCDISFITSSPLCSFQVSLRELFDGRPDSMKLIARAPEGFPTEQSRIVQFVRAPEGYGVGVIREKKVGEVWQLEQELSTLKHSGSWNAADHFLVLDHGRLFATYNNASSILTVHTTPCALTLELPVITSLFTVPSNDVHNAIMGITSDFYIVHIRILPANTLGAPVPLTLSLHYHDRLPGSSPSMVIPVDPMAWGINHPWVKHDALLSVSDSGELAFWVPEEAKSKSKKTVGNEVENLTNGTGADGDGFKKSERGWICTGRVKTSRSGITKVSCSSAKKTALVTPISEGEELTIWDSKESEFASGLEYRIIYSESINDLDWSSTPDMQSILAVGFLHHVDILCQQRMTYFDEGYSWTRCWRIDIGSDSIWLANGSLLVGAGNQMCLYGTPSNNKTKKDEMREETLFEFVARQNGPLEDYHPQILLQCLLWGTFLAEKLELVKEIIVNLAKDLEHKRIPSSCIPVEKFYRSEQTVSMSSHKKRNEEAFGRPLVKDLLETLEAENLPRLTPNEQAHLSVLIQTTLEVDEQRRSLDANGLRYLISMRSFYILNRRASSPSSPASHNCMQQKTSRRERLRYRDMIWAFHSESQDLLLSASSAACNGKMCWADARALGVPIWLSSIDSLVGSLDRNLRQIARNEYMANDTRDPTNCSLLYFALGKTKLVHGLWRQASWHKEQNVMLKFLSNDFTQSRWKTAALKNAFALLSKQRFEYAAAFFLLGSSLKDAVNVCIKQLGDFQLAIAIARIVEQSNEGPILTSILNETVLPTAFREGNRWLASWAFWLLHRRDLSVRILVDLARTLDKPIAEVGESNYDDPSLALLFSQLRGKTLQAAKGSYEISGRLEFNFVLQIARVFCRMGCHILALDLVRSWRFERPASIIDLNDSRDSGPPLSPSASRRSFFSDQPRHHLRHRSSMMIDMDISSYPTTRAASPDGTDPSRKGPEPIQEEPDLMARKAGLGNLMKSAKQDVKVPEFDMNAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ87</accession>
    <name>A0A8H5LZ87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ87"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="70"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5374993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="537" mass="58649" checksum="A86A9045C27D955E" modified="2022-01-19" version="1">MMFPNHSAFKDSETTLITSSEGNAKNHRHRKFSLSSGIAHVPGVLSALNRRSRSSVIINNVEDIKARQKFILTLAKALLMFGAPSHRIQSQLTAASDILGADSEFIHLPNIIIVSMRHGDTAPTQTYFVRATGRVALTSLHRVHLIYRDVLHDEIGAEAGTKALRQLIRQPPIYPLYFRCILAFFQASIICAISFGGSFIDMWVSGACACVLQYLGLSAAHKSSMYAKVYEITVSIIVAFVARALSNIPGDWFCYSAISSAGVVLILPGFTVLVSALELMSKNMFCGSVRIVYAIIYTLFLGFGLTIGSDFYLVVDRRARKAYYSKNVLHNLTYTHGRFEFVNGTNPLTVIQGVLGKSIPLTNEQQHIFKGCIRDPSWKWYRQPFPFWTLFFLVPMYSACSSLSNLQRFRSVQLPVMVFFSCCAFAANKGASLALPGRTDLVSATGAFVIGLLGNLYSRLAGGTAFTSMVTGVLFLVPSGIAQDGGITGQNFHSAAEQYSTGFALALRMISVASGVTVGLFASQVLGARKNAAHFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ95</accession>
    <name>A0A8H5LZ95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ95"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="149" mass="17306" checksum="AEA23DB732A1CB4F" modified="2022-01-19" version="1">MPSDCWSAGIILYVMLSGQHPFDYDDSMPESWLNHVHESHDPYNSQFSQAYMDHESRLKDRIVHDKIDFDRSLWISMPEGLLNLTPLQNCTDNEHSAKGLVRMLTVWNPQDRATVRAALESRWINCDLEMLDRTYQDRIIANLGPAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AQT0</accession>
    <name>A0A8H5AQT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_019053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000651">
        <property type="protein sequence ID" value="KAF5309303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AQT0"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5309303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="287" mass="31487" checksum="9A7BEC4F7308F911" modified="2022-01-19" version="1">MNLFYFLTTIVGYVFYASQNETSVLRSTAVQQNMSAVNSTVDLLILGAGWTSTFLIPLCKERNISYATTSRSGANDTIKFEFDQAEEDSDIFKPLPDAKTVLITFPITLSGGSERLVRLYKSTRHNSDTNPAFIQLGATSIWGTSDRSIARAAAESGSQAPIPPKPKELQWFDRHSPLNPGDRGAAETELLALAPAMPTTVLDLAGLWGGTRSMKNYSSIHMIHGIDVARAILAVHANFSKASGERWLLTDGRVYDWWDLASAWGSGSDSRNRIVKTVDHKQHGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ARN8</accession>
    <name>A0A8H5ARN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000626">
        <property type="protein sequence ID" value="KAF5309639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ARN8"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="2">
        <location>
            <begin position="46"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5309639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="22383" checksum="33E2217CE3699B78" modified="2022-01-19" version="1" fragment="single">DAARDAIAEAEKAKDMLKKGPGIQPVSWPTPKEYVRMLKARQYQEGKFHFAVAGLSGSGKSSLVNAFRGILDRNMKAAATGITETTSVIGRYPDPNPERPFIWYDIPGAGTLKTPDWEYFNQQGLYIFDGIIILTDNRFTATDIAILRNCARWNIPSFIVRSKSDQHIQNLEKELKEAIEERPPMMKNVEGSLKGFGAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ASC4</accession>
    <name>A0A8H5ASC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000606">
        <property type="protein sequence ID" value="KAF5309811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ASC4"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5309811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="756" mass="85379" checksum="08CB30F18DFE6F8E" modified="2022-01-19" version="1">MVDEPKYQVDDPNANVVISIPPGWKTTIDFIFNQKYKQGISEAYPSEDDPDDEQFNFHRNDKVGELGRTAIPARKQKFDLRLEFRYERSQEASSKLIASREPGEDSITFNIFARDKHGAPANDEKSSDMCAKIHLVNTTPPPKGPGKITQPATPEELSAPKKGAQVLDDFSKDSSIDPGKLVAGPPYTPPPELKDLPVGILGAGCAGLYAAMILDSLGIKYEILEGSGRHGGRILTHEFTTELRGQPYQYFECGAMRFPDIFLMRRTFDLCRERLGMKEDKFLKVIMHSGNAIKHFNGISVKQSDWSKSDDNGKNSADSFKIGKTSKNKDGYIPQEYLDEGTTSLYGKTLGPLRNYFVGTPFQDAFLKLMRHDKHSVRSYMRETMGFPDSVIRWIEAMEWRTGGFDSSLTESVIASLSFDDPRSTNPDWYCFNGGTRIVTDGMLDKVKYKPKYYKRVTGIKELAVHDNQAIEVQVDTSEDPRGQHAEKIHGKYSNVISTLPLSVLRTVDLDEIYLSIGQKNALRELQYHPSVKIGIQFKTAWWEKMGIIGGQTYTDRPCRTTVYPSYGVPNLSAGTQKSNVMIAAYNGLLDSQRLAVYMKGHNSPQEKILLNFIMNDLAAVHQKPVSELWDEYLDYYAWDWYSNTFSQGAFAWFGPGQFQEVYPHLTMPAGKKQRLFFAGDAISTCHGWVVGALNSAWRCVHDMLVAHPELNPNPKKDIMAEFMNLWGESEEWDDIKGAKHVYLGRELFKRQQGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B8N4</accession>
    <name>A0A8H5B8N4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000452">
        <property type="protein sequence ID" value="KAF5318286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B8N4"/>
    <dbReference type="OrthoDB" id="3069822at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="845"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5318286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1202" mass="135840" checksum="07DAD8EC54AAC68B" modified="2022-01-19" version="1">MSSNNAINNTESIFNVPILNTTNYEFWNYAITRLLEAKGLSRVASGTQKRYVNTSPTETGNAPSLPEGFVLVTNEVFNALTESEQSSYNQIVDTFAHEWDQYQILVNKHDRELVETYKLHSSWDDKDEQALGFISSYLPNDVGLEMREFTKEEVEEDPCAKAKGDYTAKMLWDKIDKKYSSPGPTSWFLDFKEFMSWTLDEKKDPANQIASLGAVLTRLKAYGFTVDDKFRALFLMDRIPQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKRRTGQSSESSLLTRITGDRRKFDSAPNWNNQKAGSSKQKNQDKGKGKQPKPQEPSKTVTTGDANQGGDKKKKTRRSKKKKGSKKGAANLANPEVEADSDSDDDAPLMVTAFMANPFINATLDPIEISDTDDLPETCEQPFYELLPYHNFLIVRSDCFIDENNDSSLKERVKRNLAKQVRPQTISGYFILTHYERLMINELAQETVDFESFLRVEARHQMTRKLAEIWDYTYNSDGTHTEPYLRAKEDLNGDEDMTNQWFDHEGTIRPIQKQIEEEVEYFCRYIMNKALADMRNHKWIPQQFKKREPVPSKPPSFIERAYWPTPAQSVMRTNGVTINTQFHDTSLYPDFIRTLPFNHTKASSSSSSRKRKAVRGSSSSESSDSTSSDHSEESSFKYIPPSVAFKMWQDRMSHMFTDPILENMKREPDESGNTSKKPRYDAPLEEEAGPSSLADAINVSISSGYLADDDGVSLGSESVVEIYIDGDETMAFWQVFHTSNKNSALIQLPQISMSSDYCESHTALAAIDNCTIITNDVPVFICEQSFVARAHCSTCEKYPLNSICKSKITDEITYWVSDSGASTHITNNLMDFAQYHKLPNPIPLQIADKRSETYLEGVGTVFIEHINEEGVKHTIKLYPVFYQPTCTHRLLSRGCILREGYYEISRDGNPQALFIEKWFPRVLSSETEESDKSTKPVQPSELMRSLHKQGTNNLPPDPVVPLDLDDLFRDQFDDQGPPPDEGNGNHQDIDDGNGSDASSEDHDPGAHQPSDPNDSETESTQSREPTPPPAPEPPAQIPADPVPVQGPQPVNPRNVDLTTGRFINREPNPNQTRSSDRQSRPNWRITDPNMQHSRDIPRGGWTRVTPRVTRSQSRATGSQTVTDPTPSTSQVREESDNEDQSETEPGPSGEIAEFLEQDVLEQRVQQGGEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRI9</accession>
    <name>A0A8H5BRI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000370">
        <property type="protein sequence ID" value="KAF5328038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225203at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1768"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1848"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1870"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1928"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1977"/>
            <end position="1993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5328038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2030" mass="220864" checksum="703403A61521C050" modified="2022-01-19" version="1">MKNYNYVNPPRRDAVSVGQPSSSDNVTIRFGTDNPGPWFLHWSMDNSPATEPSSELLTIACRFVPYDQWFITHVDASWKVAQVKSWLLAKCYNSFSSPRNASNSTSATPSASIPPINPPERPRRHTAHRPASPIVFAPERPSGSGRGGIDSDDDLEGDGHYYDEHGIYGAGDPDTAAKAGNAKDTSEGKSFTGVSSISYVSQISGLSYASTASKYSQRSGYSHSSHLSQVSEASSQTRSPVSTEDTHGLPMIDTAFGQEKNKTDTIRPRSKRGPRGPRRPVSPMTFAPMGKTPTSGQATKGGFGEYETYSTYSPDDSAPNFALPLVGATSQATNEKDGDIASIESNSTLPAYSGKFSRGDGLENNNNNSSDEEGTQFTMGYEEDGEDAYDEDDEYEEEPGHGKEKEEDYDDNQPPPGTGRVGPAPIVPNRPGTSHSTASSPSNHPSTTSLAMGNLFSSRKEKDSKDKGKDKEKRKEKKKDKDKQKEKHRSKLEKADRGDRTRDWVEVERSREKERELFTSSISAMSGISTKPRKDTRERDRDRERERRDRKVYGPLQKRADHTPSYETYHPMLVTVMRFSTGQILEDHFALGWYELKPYELLEIHRRGVILTLPRTLTVDYISPYWEGYVRALRVVLRGPNNLAVSGVAPGSSSSRGKDIREIQENRRREQVERHSSIRERGSDHRDPRSESRAHKRKESSALSRDDGKDGRPDAQATGSQSGQHHRPNNEHHDTRRGRMVKLDWRERWVFIKDGILNVWKDREDATTAQYLPLSDLTDIRGADQLGRSLTISSAFGASSTLGASSTTTTSRPTQPGQPRGQSDISGLRGMLGSTASASSQRIVCAKFKGKLRDGSHKADEVKEKRASMSLDPSHVSAYAHARTSASAPQSGSVPTGSSAGGRANTSRPSSKQSSSNAKQPQSLPSGSPPTSNPASLPSSPTLRPQISAPISLRMQENQGVQGDEGKDSVIFRPPRASYPYIKDKGKGRALPQDGHESDDEAEGGMSDGNMSALGLVTTAVESPSAVTRPGGIRPLPSLPSTPAYPGHFDKVSDSKPDVKLDGKDNQDNDSRSTTLGVHPNFDNELVDEDLTGFSSDGSLSSPVFAHSDDDSDDSNTRRGYGYGFNERKKLPKVERDGEGRRLSLGAPKDRTASCETKADEKRGQGGNEGESDNAAGEADSSYVYIEGNERPSIRPRETTAHSTPRSRTRTREKESSGEWIVLDLRDDHAFRSFLRVLHRYAPHILQSTFLSQLPYYTPPAQITPTSSTPNAYPTFFSDERKGDERLSRVLENPEMVESSATVDSNTVTTSSQTDSTTNTPLTASTFQSSVSSHTQLSSMSTSPSAQSLHHRNLPSLAIPDPISDLSSMRAKGTSASLAISRHGLNALLHHPPDAFGTFGALPYPEWRTKLVLRAQRAGLGELNKAMEWFLFKGDQSHDLGITSSLQGFGAGNSQPPLERSSSLDAEDSNDPDSAVSSKRERRRRRERHMTIEQENIAIGISTENTGPVVDSPADGDSVRTAGKSANVKVHVPDSESTDSGEESSDTEWLGWMADLHRQAKLLKEQEVKKLHAEEDEDEHLSEYNPQDDHRRYQEKQMLLEPSAVVVVTSPSQSTTTPPVSRSISHSAVSTSTPVESFGSGFPILTSPSSNESLGRPRGRKQSFGISSVDQPSSTTSPSTTSRLERSSSGSRTQHQRQPSNSRTPNLLHFASSGYIVGSAQATREKDLSFGSGTSAVRRPSMPALSSASQTQALSTMTSTVSAGHASSPLNPNTSFLQQQQTSIAAGTGSISRSTAPPKALMVPASPGVGSGSGFNIASSPRLPIGSTGSNTVPRRSSTAGLTLTANSSVSSVSLGRSGSMLSKTPALLRRKDGESEKARRSEAKELKDKTKGKSKEKEKESKGKLKEGSPYGDVSVDFRESRRPRLSVSTANSPYQPTEAQTAVSRTQSPQPTSPTASASNFVSRQVRRVRSGSSLMSEGTSEWHQSIETPRNNPPVKKKRGIMRGMTMRAEKLISNLESTLDFVDARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0M1</accession>
    <name>A0A8H5C0M1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000300">
        <property type="protein sequence ID" value="KAF5332910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0M1"/>
    <dbReference type="OrthoDB" id="3225557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="315"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="62712" checksum="190EC1C0BE234416" modified="2022-01-19" version="1">MSQTLNDLLKAKGQGMPTLSASTDDDQSARPVREKKKDALNNKVWLASKKRPNNAPQGGNAKRPKQASKPTSKAKGNPAKEVATAGKRVRGTKQSMQIIESEDNNNEDVEEDLNQSGEDGSEFDEGKEEPEESDGEQFNVDDEALNNERVETIRDGKKKKKGGKVQVDDDDIIVPDIDSKSDASSALDLSQLPSDDEDEVETQPKPENTRKASRRDAKYDSERPSIKPAPTPPTPSTTVMVSQTPSTITTGSITTSVPSNSTNTTIASNGSSNATSESFNSNWAAVTHMVFPAPGQRTISKKAQSPVVKAVLDLAISLACGLTVFDNSFANAAAQLQNCVVSLNAACANTQQPLIQDRIQRDPDYRKHLVNYIFGRVGHLRGQVKTQAAKVVSSQYDFMRLSKSERATVVKKLMDRLTYIFPLSDPSNPSTWRKNEPYRHQCIVTVLHLSFFKGSTSIANRHPDSFTSISSDDNRKEIPKSMLALAGTAIFAALKEWETGDQVEEDFSAKVFVEEYNKHLTMLEGKILRPDNSGKEKYHRLMAHLYEQASKKSSSASIGSKLPDIDFDAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C604</accession>
    <name>A0A8H5C604_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000239">
        <property type="protein sequence ID" value="KAF5335598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C604"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5335598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="25726" checksum="DC51E2AE14C456D4" modified="2022-01-19" version="1">MEVKKQDFLQDSSKEEADEAVGLRYLGNLALSPEAEERLQALVEAADALGTNDVSFSALSESILHLSERRLAAEKSLNQASFVEGELRRHLATVRYERDLIRKWKLELEPSSQTTESDSTEALEQRKQALLKKAREYRNELEDIQSNGVEEPEVTVTDLVEQRERIKTLENRIREKRAKIKVFKGLPPNLELARQELWNAREKQMKLIDIREKLLVNMVKDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6L4</accession>
    <name>A0A8H5C6L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6L4"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5336225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="486" mass="54730" checksum="144CDFAB07A5661B" modified="2022-01-19" version="1">MVLGRVISGCGVGLLSTIVPIYQSEISPPNHRGALACAEFTGNIFGYAFSVWTDYFCSFIDSDLAWRIPLFIQCVIGAFLAAGTLIMPESPRWLIDTDKDDEGLRILADLHGGDLDDPIAKAEYREIKDKVIMERESGEGRSYAMMWQRYKQRVLLAMSSQAFAQLNGINVISYYAPKVFEEAGWLGRQAILMTGINAIIYLLSTLPPWYLVDRWGRRPILLSGAIVMAVALCFTGYFIYLDRPYTPNAVVVCVIVFNAAFGYSWGPIPWLYPPEIMPLSVRAKGVSISTATNWAFNTLVGEITPYLQEVIQWRLYFMHGFFCLCSFILVYFLYPETKGVPLEEMDAVFGETDKLPSIALSSAAANERTSFLPESGSAYPPKPHSRASSRNNSGSGQGWLSRLFRRNDESRKDVGSEYEPLHVDEEHEEDAYADDMSLRRMDEGRTRFKVAEDDDDNDDREEDEDDVGGLRWLAVRISDGAGIWDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAM1</accession>
    <name>A0A8H5CAM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAM1"/>
    <dbReference type="OrthoDB" id="2961601at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60953" checksum="8DCD8A6236AEEB32" modified="2022-01-19" version="1">MPIQNFDILGSLHGNYGTYTSDIHDALKHLENAKGEAKRGEAGGKGVALWNEQRNLRRKIVLLRSLLSPIRRLPPELLGLIFSLVCVRSEIANLMEEQGEELMDCPPIRLSQVCAGWRELAWTTPSLWSSFSIGSPADLTLQHKYDQIKGIVDLHLQLSQQCPLSIHLCFLYGAYFESNCEILRLLMAHSSRWDVVSFTIDSEYLFEGHFAPVRGRLPILRSFEIFVSGGPLYSEISPESMVQDAFHIAPMLREVKITCVAPLHIPLPIRQLNHLHISNTTLGAAFECLQQATAVREITFSYRLPDDYVDDEEFQPTKLYPINLPTVDSLSLITEAANVVDVLQYMTLLGLTHLSIKAPYSREPFDYLAGPKDAIKEFFARSQCTLTSLSLCTVHIPDTELIALVQTQPSLTSLTIQEREPRKNKDHYIVLTQHFFHKMTVDPMNLQSTLLPNLKELDFRIYTGSFPMASFIDMVRSRWIPDYKQTSAPEVDCLQSVNLRVFGVRVFEDRKQLEKDLQPLRELVGLKIIVIEEDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAS9</accession>
    <name>A0A8H5CAS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000197">
        <property type="protein sequence ID" value="KAF5338299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAS9"/>
    <dbReference type="OrthoDB" id="3172935at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="796"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5338299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="919" mass="104035" checksum="8A64887EA44F2111" modified="2022-01-19" version="1">MAPRRLPPEQQLANNADDPARSNSRHNTRRSRAGTATARSTSRATANRSTSQQRPQTNVPDDIIHDNGALETAFQLQLNVSSPPPPPPPIPLPQLRVAPPSSHVLPTPQPASDAIHLPQQHQRGDRQAVTFALDPIPRSPGSGSEGEAFDFSGVNHSSSSDDEDQRPETPTRPSATRSTTPRQHTPHTPSRRHHGRMTRTPNQQGRMPNFIAHAHRPSSARRVGTKRSDDPKTNDVHKFVRKDSETQRKYCTFCELLQESNPNHPVKSYEMSTGISNIRNHFSRAHKDVWFAACDRFKFKVGGRYKLDYESWRHDQNLPAAEVGGGNIQAEERVPFSMGAFVDALVDFIVADDQSIYVVENPQFRRLLLLLREELRDEDIPSRETIRQRILQKWNQYIEYMQNRLKAAVGKIALTEDMWSDPNLRGFMALTAHWIEGKPATQGGHLILSFECALIGFLHVPGKHTGKHLARGLMFLCERLQIIPKLGGLTMDNASVNNTTAVEFANELNVIWPSVEWDSHNDRLRCFPHIINLACQAAIEVAEDKTREGRGVSANLTGALTTLRSGIREIRKSGQRRDDFQDLVVAQFQQTLQPLRDVKTRWSSTQLMLKQGRELSEVMEKFLSNPTYGLMEYVLSQNDWKALDQLSCVLAVPHNFQQLLSKERTLTLCDVLPFFMQMIELWEELKVQLPDMVDVIDVGLAKLRDYQAQMIDVPSYTYAMVVNPEIKFDYFHALNDGGNRLRGAKQMVVRKLSTYRGSADVQPSHSLGTGHLSEAEAMFTRRGRHNVTRDSTVEEELNAYLADPTVGTTSLNYWQERQKIYPTLFKLAMDVLPLQASAVPCERVFSSAKETITDRRNKLSPILVEALQMLKFALRHADPLNFTSHFTVENETEELILTLDAEARVSSDVQTFIRELMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB91</accession>
    <name>A0A8H5CB91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000195">
        <property type="protein sequence ID" value="KAF5338555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB91"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="25255" checksum="101A387A0C845349" modified="2022-01-19" version="1">MFSGIGAWVTMTPPNPVPQKSEVSGSANIKWIGSKAAYITKSFPVAVSFLESLSIVAAIFDIPVLKKISMLPMSTSSPQLLAKPPAFYIGALLIVFAGYIRCRCYQEMGRNFTFEVAFLNNHTLVTTGPYSIVRHPSYSATYFYTAGVILMWTSDGSWLDQGLLLKTFAGWIITCLWSIWWLMMIIMLTLRILKEDELLKKNFEKEWQEWRAVVPSRLFPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBG6</accession>
    <name>A0A8H5CBG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000193">
        <property type="protein sequence ID" value="KAF5338674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBG6"/>
    <dbReference type="OrthoDB" id="1534087at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="297" mass="32645" checksum="ADF0CCCC4A2BFE66" modified="2022-01-19" version="1">MTPLDNSSNQTCTGNQGNFFPEARDFEIIGSTINNIGGNVNYNTYLQERTPKEITARDLLLRTPQAPAVFTGRSNLVTEAVNILCETNQVHIAILGAGGIGKTSVALHIMENPQIKGKFAGRCYFIPCEMLLDATALVQGLVQAIGLQVTKGKDSLKLSLDYLKGCQRVLLTLDNFETPWNSKDQSDIKNLIEMICSLKSLAVIVTMRGIDGPGQIKWHKLGGQSGLPALELGPAKEAFFSFSSDGDITIEKEDPILERLLIQMDGMPLAILIIAQLAKRLSLKVLMEQWIARRQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCB9</accession>
    <name>A0A8H5CCB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCB9"/>
    <dbReference type="OrthoDB" id="3182995at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="324" mass="36568" checksum="4D76A22A233ED953" modified="2022-01-19" version="1">MDSFFSLLFPSLQPTPPTFSKPETLSILESWRDVNFDPHFDFHAEVNVDDFIISGQCQWVQVWNGRIHHKDQTIEIIIRIFQQSRFPFYCNGAEIAWNEACAYKQLKDLQGTIIPRLYGFHKVYVPADGSEEPCFAHIVEHVALSSLESLKKYGPLNEEVLFSLLDTLIPSLHEMHNCHIAYNKLWVNNVLVVFVNFALSSEEDVDSIREDGDFVVGVVTHLHGDLAVPIVMDWKNQHDKEPYAMKTFENVLLYGQERDRAPLVYPEPCIITLDDIATGFGFGGLDAGAAGHNTVVVSGSNWNDAASPFSVHNAYNAADMATFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGT2</accession>
    <name>A0A8H5CGT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGT2"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36818" checksum="D291D430603221E7" modified="2022-01-19" version="1">MPSSFLTTPDIAGIQLSLRQHAIEGMVFGIELLLTLFTILLLCQQGLRQSLMRTFLVAASGTMLINSAITVALDLVGDIIQVHALLDPTYDPTSMYFNTEVVTVVLARLSYFLGDLIVVWRAWMIFKGEIVPRAILLFCIIQSFACSIYNAVLATKKLLGFILVDTNPARIILPVSLLFTNITATLLIGYKAWQYRQSVKIHLSNLNTTSQVEQIFVLLIQSGILYCILWVLTLPYSFVPAYLHSVAVYLDVIIPHIEAIFPTAIILLSYLYKSQDTILSAISVSEEMEFAVPAPTSQSALSASTHPHDTQHVTDKESSDIQEVHRGDSTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLU7</accession>
    <name>A0A8H5CLU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLU7"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178:SF9">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57156" checksum="86C4EDDF44454B1B" modified="2022-01-19" version="1">MAEKDTTARLRRAVKENNLFLVKRLVQRTDQRNPDPSYRRYTSLAWAAVLGNEETFEFLLTNGHDDHECSKDSENNIIPMLLADQKAFVTTPYAASNHDSKGAALRMTRLYFDRYPHTLDWPNSHGKTPLHLAAQKGDEELVRMLCDLGADYDLADSEGNTPLHYASAWGHIPVVQLLIERGCQFSARNDDGFTATDYAYSFSTKETLEDTARIQFENNKKSRRAVFAQAASRGSEMSNIPPIPINGHARSRDALSPAPRLRSGSGTSRTTATSDSGDLEPNGLAAPRSQSSLSTSSSPSSSAVLQSHLPHSYNHSNTSSFPGSLNPPANPSSALSQLASRVRERDADAMEKYMRRNRSESASTDNRSVNGSGHNANADSISSLNVFTSPGTSTPKKLRPSISASQLRSPASLEGLNEARSAGRARNGTTTTSASSRSHQPVLSRSSSVSNSLSPGSISHPYANSTFEEPASFTGPPSQYAQFPEPPPKPDNTTSRRMGGLHTLSKPSLDSLAVGHRRGMSTSSYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN41</accession>
    <name>A0A8H5CN41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN41"/>
    <dbReference type="OrthoDB" id="431454at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48376" checksum="06572BD366D5B072" modified="2022-01-19" version="1">MLTFMGEYEKAIAIINNVEKLHQHQINQGTSDLEVMTSSSSTSINYTMEQTQAECYQRLGMISYYQHGNKESQCKIQQAMDIYKRIGNIKGVAQCLEHLGDISRLLGQYEEAKIMLEQAKEQFEEIGDRMGAAQCLQSLGDISRMLGQYEEAKVMLEEAKEQSEEIGDRRGAAQCLRSLGDIRRMLGQYEEAKVMMEQARKQFEEIGDRMGPAQCLQSLGDIRRMLGQYEEAKVMLQQAKKQFEEIGDRLGASQCLKSLGNISYMLSQDEEAKIMLEQAKKQFEEIGDRLGAAQCLRSLGDIRQMLGQYEEAKVMLQQAKDQFEEIGSRVGVANCLHSLGEIAYKQGCFIDARLNVEKAKEYYEAMGVLDQVADCIHNLEIIQKASAAHTQPHSIEVEALQEPNPPLAVEGQRDSADVESQESCGCCQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP25</accession>
    <name>A0A8H5CP25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP25"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="148" mass="17345" checksum="34F9CCDA60C00C8A" modified="2022-01-19" version="1">MSTSSSNRDSTQRPTTQLRGTLTADGRITPYYGLGFLIDKYELIDVFDPDGSCGSWFSSVEEEFISPRWWQQYGDKCPSPYFNILEEDQMFVQFGSNRTPSMSAKFLVREELDSLLEVYMDFFELPHHYVDQVLWYRFPIPKHHDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP95</accession>
    <name>A0A8H5CP95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP95"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="507" mass="56009" checksum="F296374DBDB5D508" modified="2022-01-19" version="1">MTHRPLLPPELWTHIWSFACTDDGTTGRTLSRVSQYVYATSAPVRLQSITLTGLHDLLAFAYMIRTSPEADRLLLRVRYLTVMADPMPVSLQELEKEIELRDRLIALNRTSSITHNTPSLPITTEERQAAEKKRERFFLHTLFNLLRLLSPVLLELELSLQAIKSPNFLSHVGCPSSVWPHPHPHYSIHQNFGPLEFPRLSYLFYACPPSGAFLWTPTTPPRVSQPLAEVNLPLETSSNSDVLSEQESYVPFVCPWLKELTIVCDDSEAGDPDDETVAEEEEQEERVDEMQRLPREEEEDNSGTSNKGPDADPDSAPTALPSESSPLVTLAPSLRNLTLLASSPAQAITAMYSASCIADSDSSAFSLLSTSRSIQAELDLAAAAAEWEAIYMTTGYGYHDVTSSESSTSPFSSSELHCSALESAVDGAALARVNKGLPESVEQVLCAPRARWDQSWDAFKTGIKKGLAQKRKMEAEAEAEGEPQANSEAEEEEHGPRICVVNRSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPN4</accession>
    <name>A0A8H5CPN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPN4"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="1">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="519" mass="58341" checksum="F2958DA8E4ADE7F6" modified="2022-01-19" version="1">MSPTQAVRNGAVSIDSLSLASERTSPELQFLFPSHLPHPHYIEYFMGLKKSELCLESTINLISLQPSMSRVLKAGKWSFAPTEETLELMADLQRYNYANPMSRRLHFAKVLPFKEYEYELINLGITDRIFVHGSHGTTHFDYPYTDMPQFKSDIHPFLVAAHCHLTLFECEDWSLYNAALDRLFSLSCLAAMWSCDVPMEFEQAYPDQHGIQPYALLWFTKDPFVQPPAPVLLPSKFSTLITPDPLPRSQLLFCPSSLLLNDHPNQSWWTPGKIAEGGEGLDIWVFIAVTRAHIKLSELGETVRRGEIDVDGKVVMKSCPMKSEDGSVNESIEPGVDIALSNAAEEPVWYFPGFRNPPSSILFEDTGVMYHELITQPDIKTFLPPIGNFTVYMFGDLPLLYSSSPDVHVTLRVHDELYSDGAGRAGGYGTRRVFGCFRKEETVLGEVVRNLRKREEDSADGYFASKEIIIPTPMPDVLHWLGIDINGHGSVGAEGKKGGRGDNMVSTSDMTWDGHWEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRW4</accession>
    <name>A0A8H5CRW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">D9758_011428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRW4"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5345931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="102" mass="11257" checksum="E4E7D65F98929599" modified="2022-01-19" version="1">MSSGSSLQGYVDRRVLLILQDGRAIVGVMAGYDQKSNVVLSDSKERVYSMEEGVEEIPLGLYLVKGDMIILIGEIDEAIDQSVDLSTIRAEPLPPIRYDQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRY9</accession>
    <name>A0A8H5CRY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRY9"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="587" mass="66056" checksum="7E781C9ED8023967" modified="2022-01-19" version="1">MSQTMRLLNTDTLNLFEFPGSHIPPYAILSHTWGKEEITFQDIQSSSRDALRRKAGFSKLQSCCNLARAHGFEYVWIDTCCINKDSSAELSEAINSMYRYYQDAEMSAGMRIPERSILPSEIGMDSPGAFSACHCHFLDVDWVEIGTKSSLQDVIEAVTGIPCNVLLDNGPQRISIATKMSWAAMRETTRAEDRAYCLMGIFGVHMPTLYGEGEYNAFIRLQLEIIKFSHDRSIFAWKAAEGGTEMTRGLLAKSPYEFRHSGNVRISDDNCGITPFSMTNMSLHIEFPMLPVLDELDDVFLAFLDCRLKKGGEQLYVHLKRVGHPDQNQFVRCWPDEIELKHASWRPPGTMSVYVVHGAEARRKKGAAKTCTFNLKPLHGFAGLAIKSYIWQSIEEQEQGDQAPEIPFSGGLDQDPKLFEVSNGSDIALLFLHEATGEKFAVVVGVHNMHIFSDIATDAGLGMSAFEHELFKESYTLGNRRHIPGRALDRVSRSLGGERFVSSAIRKKVKLGEYDIDINITHGQLLMIRELVPPEYGFLVKTDLPPSYDLKEVYPPDVFLRTQGDPDMLVNVYGHDKDSRFIQNDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSH6</accession>
    <name>A0A8H5CSH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSH6"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="161" mass="17573" checksum="47D4377E7E0B818C" modified="2022-01-19" version="1">MNTLLRFLTPTFTTFTTSTPPSHASPSRGLKDTYAKEGPINVYWDNVGGSTLDAALGNSAVHARFIECGMISSYNSGGEPVSMKNLMKIVANNISMHGFIVVHLFSKYNKEFNEVIPKLIKEGKIKHREDLTKGLEFGGEALLDVQVGNNTGKKIVVVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT09</accession>
    <name>A0A8H5CT09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3357948at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1712" mass="187664" checksum="05F38CF639897E19" modified="2022-01-19" version="1">MGRHNYPDLYSQQLLCEGHGYPLLDPEPHLIGEELRADFRKAYEEGVRVGDLGLVEISGNFKFIFNVFKPADDPINTVHGVPPDFQPLPYHDDRFSSRSLYHRKNASVCSKKARAVVLGTSGETVSTLFGPGLDLQFQFAQSEGAALFLPAGADRINYSAFATMREYITKNAVSWYQFVNELDLGAYNGCLYLITGYDRTSCYHNLAFSGSSFQSSLTFKFSSALMPTGNVGLSLSYSSVPSDHCWLGASQPTHTLNNLSPFIRGFKIMVKPSLLSSLKLSIRTWDPATAELLSKTRQACLFPNERFTPPGSSHSDSFGFDPPSEAPTPSSSDPSVRSEPLRELPPTASDSSINGDSDSTSRSSGSGSGSEFDSDVPIYQLYHPSDIINAYTLEKCPNVLVAITHDDEWLAVLKETDRQIPDSTTLITRMLQEHPLRFEQVEASLANTAEDSNDSLNFTHGDPLIASPWQQPFESSRSDAMQAAQPSAPFTATKRPLEADATSLKSSANRPQDISDQYGDYYDDMYYDDNRSDYTYELDDGDSANRIEVGSAQFDVQSYIEGPAVPGTWDTSSAGVSSSYHGRRASTTSSSASSNDWRRLLGPVNPSTTAVSPDFASTNSLDLDDEQPYDFSPPSSVDPMLGFNLPYIMRDLSSSSLPDFVSKSTTPEKKKVQEYTQYADLSQRRSYSQTPSPYQAPPLSPLSPTPTEAKQQTFPLLPVVQQLQESGAASLLGRSLSILSAQTTGTFALDDSFTKGLMTWSGEGYGSLRREWVMKKDKESSQYRNPSQNFGHGKKVWKGLYPGDKEVWHNYLLGNFSVAREDISSGTSSRTSNAHEQSAQTQSRNSPNTTKERETPKDRNHIQQRLVVRRLKEPIPHIQSTAIHPTLSTSSFAFSSANHFTAASEKPSVTAIDHHSSPPHNRNTDPSDERGNPHIQVAGSSDSATTKFDPLVSVGSDTTLVDQISHTAPTHTTNANATNNNIPSTYATTAAATTASVATAGFTQSNAPSSTKRKSKTNSDSRHPPVIVHRHSKVTAFSISRHYRSHATGGSGEGGVDSSVKGNSLGMKPKADLGPGNNDPSVRGNVAHRDSDVDRKGGRDRDREKGRRNRERGTTTSSSTGAGSSGSKRSQIVMLATREVQEQFFDAHSTARDTKNLLVGAGLAVDKRNIKEKERERAKEKERSERERYGKRKMKRKEKDGEKDKQSPRTHPSAVPKQKSESVLGSRSGGRDDISVPDPYPDVMSGFVPLSHKSSSSGTPHLPSSAVGAPAIPERPTRLLEVDTDRKDTQSMSHTKSESTPTSPRHDTPEQQHQQRPTRPRPHSLGQPQPSRTSPTQLQTQPESSVQRVSPSQQTAPGLLKRLLKDSSSTPSSSVTSSRVTGTTTNSVTGVNSAISSSASGSTHAATSLTIPSFRHEDVHVQRLKMLDDLETSLEHIGLLPPIHERERKQKLNKPGRQRLDIVASNYSHHLRESVEKGKGWSGQKKIAEEHDVISFIPRDALFMILPLWPEETDFYSQRRTPFVLPEMSEEERMYLLVFFKSTKKEEEAMDTGSQRGKEKDPTVAINMLLSSFHVVALIVSHEELQGIRVTLPKEGLIVTGSLEEAYKARPSAPRNYGPPTDCLLANCNSRETGLEFDPEALIQLGLCSVVNQASGGEGGVNDDPLPLGRFSEEFDTQRLRSSEVKLTPLGSAVMETIWCGSLALMSFGTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTC4</accession>
    <name>A0A8H5CTC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTC4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="130" mass="14209" checksum="7B18235BBE62ED2B" modified="2022-01-19" version="1">MTQATGPPSPIPTTVKGISLCKSMQIRRSTSIVLRILGIHMKVDTGTTDIWLQISSLASPQAPPHTSASSQPSLYDVRTIIFSLSTQSRDSQRKTKATKPYYIDDPGARSLVDFQHKLVDSRLGQSEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU60</accession>
    <name>A0A8H5CU60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU60"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="925"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134625" checksum="C2DDF0DEF8188777" modified="2022-01-19" version="1">MSHLPPLLPNRLHPRPSDDNNDPDEISPSVALALKLSTLPSDLFDQVLASLATFPYDIWDDDAMKDADIIDALQSDMDARRAKMTPRDKLEIAMLFVEEFDKTRNLDSLNQAIAMMEGAVNGFNAEQDTKGVFLVLHQIIPCLTRRFNLTGELKDISEVIEALRAAIRISPDNDQTAEVLYTLGDSLLDRFDGFGEQDDVMESLKAFLKGLSLLPEDDDEHIPLFGKQIAESLKICLARPQLLPIFTATKDDLVDGTASDSLSKRKRAQILRTLGEELLEQLLEVGGIQNLDECVDLLRAVTDLDPKNANVMTFYGLSRLIRFERLGDSEDLSTALATQKATLHLVEETDERLPGILNNLGNALQARFEYAGKVVDIDEAVNVHIRALYHPKVKEEERFTFQSSLGTAYHRRFEHLWDLMDLDASVDAKQMAATTVPNDHPTRAQLYASYGGVLLQRYSLSHRPEDLEKSLEVQQEAVELTPPTHPARPLRLLNLAQTLGDHVILTRDLRSIEKAISIAEEVIPMANSNSHHLALAHLRLASALRMRYLVNKDTQNDICSDDLDRAVDAARRAVDTLATLPTSLHMATFCQELGDCLLVRFQDAESPSASDIDEAIAAFKKGAEVPSNPVLLQISCAIEAARLCTTFRGVESGIIAYTTFFELLPKAIWIGNGLHRRYEDIGTIRHTLSEAVAVAIQAGELNLALEWAEQGRCIVWSQILQIRQPVNPALGNLAIEMESVTSKLQNMGMESRPSIKYPSKQTTALMSAAFLHFSSLEDEPVPIEGMSREEYAHRLAILPTLLLDANQQEQRRLAEKYEDLVIQAQELSGSDGFLRPKRFSELYAITSQGPVVFINVCEERCDAICIVPGQKEAVLIPLENFSEEKAMETLSSLIDDLEEKNFRAKFRGYSKLTARTEKIRNILGILWTDVVQPILLKLEEHLVAENGNLPHVTWCPSGSLSFLPLHAAGIYKNNESYVGQRIFDHVVSSYTPSITALLAAQNQNSTQPLAAPRVLAISQPNTPNEAELPFTVTEVETVQKIHPDLTWLNDTEGTKDAVLKGIRQHDWVHFACHGVLNLENPLQSAFLLQDGSLEVADLMKESFHHKKLAYLSACRTAAGSEKLPEEAVHLAAGMLMAGFADVVGTLWAIGDDDATFVAEHFYRYLKEEGSGDSRLSSYALHHAIRKQRESIREDDFYRWIPFIHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVD7</accession>
    <name>A0A8H5CVD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVD7"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32545" checksum="03A598284EB5316B" modified="2022-01-19" version="1">MPSIHEVPINATFGAFLASRDFQSRVTPNGTQRTTLIVAAVYILVIAILWHIPFLSWIIYPFKLLTVGFHEMSHAFMGVLTCATIHSIELDPNEGGATSMSGGIQWLTLPAGYLGSSLIGACLIACGFDTNASKVASLVLAVFFLFTLWWARRDWLTWVLIAGMTGLILLFWFVAGGVALRYFILFVGVMSCLYVLWDVIDDTIARKVNSSDASAFAKVCGCCPSQVWGVLWLIVAFVFFALGVIVGLVAFKDTAAEQKEDASHFLPVPGSSNALSSTPSLSMTTTLMFFVLSGTAFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVW7</accession>
    <name>A0A8H5CVW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVW7"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="709" mass="80057" checksum="7844A4EF96ACDA84" modified="2022-01-19" version="1">MKYIGMRLLRKAPTTPSTYIVDSFSNRDIPSYAILSHTWGDDEITLADLDSPLPNLVNSSGYRKLESSCKIAHDGGFTYIWIDTCCIDKSSSAELSEVLNSMYAYYRDSVVCYVYLSDVSPGLDPRASGEGSFRKSRWFTRGWTLQELLASPRILFYDRDWNRIGTKSSLRDVIVEVTNVPAAVLLGHTDIQSVSIALRMSWAATRVTTRPEDVAYCLMVSSEYICHLFMVKEREGRSFVCRRRFSSITMIQQSLFGKRQIPPAELERPAPTEERSSLSSDELTNRGVRIALYLRPITASESYSKLLVVTILTTGISSVMIVHLADFLEQYHYLAQRCMGSHTATFDTRQEIGYNTLAIRLIVIALMDTIPNTSLANCCCIMAFVLSTWCTTVSQRSILYTYYTSLRHLYRNGAPNVHEEVLYALLPCWDANGRPIAIFLQKTTESRDYLRLNPDQLVVDDAALHRGWRRDLFKKSEIFVKEEVFKESEVPKTRQWRWKLLLSRHLRIVDSFPVQMYDLSQMQSISDPEAARTSAVTTIDQKAGPSMDDSYLAEPAIVDVSCIQLPLATLCDTLVIKLEKREGNNDQFAIAIGQSELAVGPRMGQIWVDIIPEVKENLTEIHKSYKHPHKRADMIARGVDEVSRQLKNGAVSVTTNYIQPVPCSRQSIVGFHKDPELSESNAPCCEVSVNTDEDEAYVLIPAPPLSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CX57</accession>
    <name>A0A8H5CX57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CX57"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="402" mass="45355" checksum="2F122BAFD7615603" modified="2022-01-19" version="1">MAATTMEKNAAKALPKRLVNTYTCRLIDFSENDPTPPYAILSHRWVLGEEVSYQDYLESRPDTKKLGYWKIRRACMVACIQGFDYIWIDTICINQGNHNEVAQNINGMYSFYQHSEVCYAYLADIYKPPGNDGSADLISKMWRSGWFQRGWTLQELVAPRNVVFFSAGWEAIGTRSFLKFAISSLTGIPATVLDGSRPIEDVDIQERMTWCFNDPGLYCIQTVLWNSKATTSTSCFSVKTCVLKFSQRTMSTAFTPAPITPQHLLPPSIRIRCHLPLAMICPTTIHIYLLRLYNISHQVFSPQSGLMDPDLKFAVIAQTSMPAHFTGHPVEQAEIAPSAGILETDDNPDLPHHPLKKFVGPATACFVRTHLLECMWPIDKPSVKDQTTESKDFEGQNCPNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYE4</accession>
    <name>A0A8H5CYE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="16">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PIF1</name>
        <name evidence="19" type="ORF">D9758_007855</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="16"/>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYE4"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="18">
        <location>
            <begin position="422"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="16">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="626"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="684"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1087"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="799"/>
            <end position="806"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5350252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140005" checksum="7BECD164843CFA7F" modified="2022-01-19" version="1">MYLDYKKYPVRRKRRHVMTEICASSVFPRVELVNGHPQSSPDCCNQRLAIASRDNLGRNIPRDDAFRFFSVCWAKIGNLSGLELGQGRLPSESSCFVVHTAKRAGIQDRYPTLACYSRSIRVQYKTSGLQKNLEAPGPSFKAAASSSSACGRCRSLVVIRASSRSGEREDSPRELTTRVLPLFEFTTTYRVLTMSKTAQLLAEAESISKTDTKRAEALYKEILSSSSKPSPNEDNQQQAQTVRDQETALVNLGQLYRDQKNAEGLAEVITLSRAFMSSTAKAKTAKLIRTLLDYFNAIPNSHKTQMNVLTDNIEWAKREKRIFLKHSLETRLAGLQLEAHQFKQALVLIDSLLTELRRLDDKMILTEVHLLESRVYRGIGNLAKAKAALTSSRTAANSIYCPPHLQASLDLQSGILHAEDKDYTTAYSYFYEAFENLSSQGEDDERALGALKYMLLCKVMLNLPEDVTALLSIKLAVKYAQLREVESMRAVARAHQERNLADFEKALKDYKDELSSDPTIRSHLSDLYDALLQQNLLRIVEPYSVVEIEYIAECVGQGRQSVETKLSQMILDKVFHGVLDQGRGCLLVFDEPKADNMYGAGIDTLEQVGKVVESLYAKMGLERQSSKNSQALSGLRTIKRDFSDNPSTSQPAVKREPPPPAQAVLDPAAEARRLRLKVIQDALNEDVPASKPNPDPPAKPLSQSRSFNKRPSDASLNLGDSEPPQKKKRNLPPSWKGNDGTTASAAANHTRTAAGMKATVLRETRTSGDSQKPANVFLSQEQTEILKLVEGGMSLFYTGSAGTGKSVLLREIIKTLKRKYGKSADVVAVTASTGIAACNIGGVTIHSFAGIGLGIESAEELTSKIRKNKKSSGRWARTKVLIIDEVSMLDGDLFDKLAKIGSILRNKKLKPFGGIQIIVTGDFFQLPPVNKTSSVKFAFEAEHWSTTIEKTFNLTKVFRQRDQEFVDMLNEMRFGELSQKSIKRFHQLSRPIEYDDGLGPTELFPRREDVDRSNGTRLQRLQDADVTYQAVDSGTADPTQREKLLNNFMAPKILNLRVNAQVMLIKNYDETLVNGSMGRVVEFKYPNELDDNEGSSSKPPSTAGSSSASKKPTKAQQKYPVVEFLIPGGGRSTVLVTPETFKVELPSGEVQASRTQFPLILAWAMSIHKSQGQTLERVKVDLGRVFEKGMGRLVHLSVLVLIVTLGQAYVALSRATSMEGLQVLNFDHHKVKAHPKVVAWTRTLETIACGEQEDHDASWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D062</accession>
    <name>A0A8H5D062_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D062"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456180" description="ASST-domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="65861" checksum="58AD7429102AB8E6" modified="2022-01-19" version="1">MSFLLHAFQLLSLTLAVSAQQNPFISRPDLVPTPWNITFTNTSSSTSSGEGFIFMAPRVAAPTGLMIFDNDGNLVYLNNSDVFQNTDGSHSGVFDFRPQRWISSDDGSGKSVNDTFLTLWAGTASVAGFGRGRVFMLDHGYEVVKNFTAVNGSDIHEFHINSDGTAVTTVYNLIEGIDTTSIAQSPLGQEDSFVWDGCAQELDIASGNPTNNFLFCALSSVSPQSTPISVLDSFTAPATPPTDSNNGWDYVHINSAEKDAAGNYLISGRHTHSVYYVDGSTSQIIWALGASTAQADASGPSFPSSHPSNFTGDGNEFSWQHDARWVGEKGLSGDDIRSANSGNTSGPLAGKRLLTVYDNASAGFASSGTESRGLLIQLDFSQSPWTASIITSYHSPGGESTLLSASQGNLQFLSEHPELGSDNVFMSYGNLPVFAEYTREGDPIRVVHYGNSGAAQGYRIFRAMWDGTPVSRPDVGVDADAGMVYVSWNGATRVVKWRLTQGDDASSLSSGNETNVDKQGFETAIAIDTTPEVLQVSALDKDGNVLAKSNVVSVKDGSVVGEGQDGVKANSSTDASAGNNGTGTSGGGGDDNAGVSVRMMGMRVSGTTLVWGMTIVVMIGGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0E0</accession>
    <name>A0A8H5D0E0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0E0"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5351320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="539" mass="58402" checksum="E66091556E610B35" modified="2022-01-19" version="1">MSLRSNVARICSSVRRYSSDARAIIRERNQNVNAFVSINENLPSSSTEDPTLHGKTVAVKDNISTSSMPTTCSSAMLENFTSPFDATVVKLLQDAGADIVGKTNCDEFGMGSLNVYSVHGPVINPFRIDERRSAGGSSGGSAAAVAAGMCDSALATDTGGSIRLPASYCGVVGLKPSYGLISRWGVVSYADSLDCVGVMAKTVPEVKRVFDILNVHDEQDPTSVSTQMRRNTRHIVDQISHSWSKDPKSLSGLTVGVPQEYFPRELSPSISHSVRQVIQHLQHLGAKVVPVSLPSTSYALSAYYVLASAEASSNLARYDGIQYGLRVPPPPGSDLTKTSNLYAHTRSKGFGSEVKKRILLGTYALTADAFDNYFLQAQKVRQLIRQDFDRVFRYPNLLIRLHQNHHVDSGSELLSLSESHHGQIDVLIHPSAIQTAPPLNANANAESSSESNGEEQDKDKDQKDRDLDSYVQDVLTVPASLAGLPAMSVPVPVSLSHKNHTEQRERDKGIDGWPVGVSVVGQWGCDEVVMRIGQVISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0F4</accession>
    <name>A0A8H5D0F4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0F4"/>
    <dbReference type="OrthoDB" id="3065313at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="384" mass="43665" checksum="08EB686F3B8BA401" modified="2022-01-19" version="1">MSFWSPSASSKWAEDVAMASVNDRKASAKSRPVDLPVPITQTQPPPKTLPGRVISSIKSLCSQLNSGVRERLATPSTGNFVVHENLRGRALGLKEDDDLEAPKRLQGDDEEVDEVVVDLLWMNSAKASSASDDGDSTSTSHSELQRELFTPASYPRQSGFGVLRMPWLFSRAVVWPLVKQFFDSRFKDRDVEMEYRKEDWVHSKRLALWASIFFILNWIFGAIFIPAPAVLADKIYYYAFEPIFSLPLFLMCAYDWPRDHSNYYQVYLTIATWTWSYYQVLFGFLCGYSGDNNLFTCGSKDFLSTFYYTTALQTIALFGTGLKRLPTLVGGTVFLVLSAVLIIPKRDAWARNVINFALFQIFILYVHYRREQAGFVHSLNNHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4H8</accession>
    <name>A0A8H5D4H8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4H8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15708" checksum="ACE22A2B7F9901A8" modified="2022-01-19" version="1">MPDLPRLLEGPVAHDPIPTCSPASQVNLTTAWTVAAIYLADNATFGTLYSSPNDASPLLMPPCFPHLPSSDTPPEIVKSIFEAFTRHITCELCLKNRDKRIDEIVAAWAELQESPVGSQYLFSFPFRWRTGVNFNSKSGGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5J2</accession>
    <name>A0A8H5D5J2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_013773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5J2"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5353598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="568" mass="61985" checksum="F99C7AF1A7606876" modified="2022-01-19" version="1">MLQAQQPSSLPLSSSDLVVLKSWIFRTAIDWLIHGFNATLALTIFFAILSQQTYRSGPQLMLLALVVVMLILATTIATLDVLFILLEIPLNGYNVVNVANIIQQATDINIASGMVSRLNYVIGDGIVVWRAWVMFPRNLVARGVLVICFMGSLGGALADGGLGAVRLLHDLSDLGAKNNVLIMALPLLIPNIAATGLIGYKARAQKILILLFESGMFYCGVWIVYIVINLSNETSSIAFQTTSATLPGLATLYPILIILMVVLERSREEIRSRNDMSLSQSIRFAPVQTAASQTESQVERQAEVMSQTVGIPYHDSSKCNLYPDTLCSVSYARYSEVSPPLVFVGEVILQLYPFFVCGKSASFFFFFLIPDILPTALRFLLASLISTESPTTNTLSPNTNPNPCTNTLTFRLAHAHALTNESGTIFRDFKGNGSGNDGGGARNRSRGSFSFHGEDDIDDFDPSSFWSPETIPAPNVSDRYTLLTLAKMMQNAYFSPPTSGGSSSDWYDLGPEWNPNSTFSYGWEPDDDGFRGHVFVSSTNITSPGPDGQTYPSSPELVVLTIKGTSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5Q7</accession>
    <name>A0A8H5D5Q7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5Q7"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF25">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5353688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="436" mass="48734" checksum="B736B0AB6D64F4DC" modified="2022-01-19" version="1">MATAARKDDVIRIWRDIAPTPGPLKSPSKHSPRVLIVGGGVIGLTTAWTLLDKGYHVTVLAKEWASYGKEQRITSQIASALWEYPPAVCGQHTDEISLQHSKGWAMTSYNIWDAISASPELSKASGVRMKGAIFFFPRLIEEDPKQLRKMEEIMACGVRGFRHDAKLIQERDLSPSYGAVDAYEHLAPTIDTDQAMTWLKGLVESKGATMVTRTLRGDLFSQEDNLRAEYNVDVIVHSTGLGGLHLAGDETCYPIRGGLIRVINDGKDFPKIEHAMTISADAAGTTNEIVFIVPRNDNILLLGGIVEPGEGKLDLMLDSPIIKRMRERCERFYPPLKYARLDPDYPFAQGARPFRKNNVRVERELRFHEDLVNGRRFMRPSRIIHSYGHGGSGWSLSFGCAGDMLRLVEEALLDIVPVPLEMERPARVLDYPMVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6N0</accession>
    <name>A0A8H5D6N0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6N0"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56595" checksum="21970EA17AECCB9C" modified="2022-01-19" version="1">MTERRSASADPKLRCANRPHVFHPALNQDACYIPENGDDPWVPCKAQPYLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTNQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGLNGTSERGRKPDTFNGERSEAKRWLAQFNNYLRMNQGRYPTEESQVSLFLSFFAGEKGGDWATQRLTERDADEEDKELKATPDQRRWITLKEIRDRFKKDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFGEAALLEFYQDGLPSKLREAVGRTYPKWKDFDQYQERAVELHLEWLKERERQGRWKTTSTSKNSPGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPSRTIRTTETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D866</accession>
    <name>A0A8H5D866_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D866"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034740084" evidence="1">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="21907" checksum="E9879F79AD089541" modified="2022-01-19" version="1">MHSLSFLLLALPATLALHVPRQAVDFFDPRQNGGSMLDDTGNGLGEPLNVIISGLSSSEVLSEEGIVNYAKAIGFSEECLGIHLGDPQSANLGDGNGPVNQTIELRQDYGDPDLGTCLESLIGGNHFRVFIQNGPQQPTGALFLAVSQEEDVTQGHTITPDGYNIGRDLLVANALGDTSFNGVNYHTVGRNITGLLPVGTQGVNHGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D876</accession>
    <name>A0A8H5D876_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D876"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5355305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="25293" checksum="F75FCB09424D6EA1" modified="2022-01-19" version="1">MASLCGSTSKSSAFGRRPVRLFSIRINLCLHFQKDTEKSLCGDGACGKTSLLNVFTRGFFTQVYEPTVFENYVQDIYVDDQLVELSLWDTAGQEEFDRLRSLSYAETHVIMICFSVDNPTSLENVESKWLDEILEYCPGVKLVLVALKCDLRDDWPVKERLSRYNAHPVQYEEGLAVARRIRASRYLECSSKHNRGVTEVFYEAARVSLSTRAKGSGDSCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FER7</accession>
    <name>A0A8H5FER7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000281">
        <property type="protein sequence ID" value="KAF5333882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FER7"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="256" mass="28802" checksum="3A0F847DA972E716" modified="2022-01-19" version="1">MTKAFNDIAKYGVAERTHFLDGWMCPLYKKNDKCNIANYRPITLLNTDYKIFTKVLATKLGKVAPDLLHHNQAGFVPRRQISDQTKLIRMVMASAEQSAQNGLIVSLDQEKAYDKVDHEYLWKTLEKFEFPAEFITAVQHLYKPAKTSVMVNGVKSDTYNVIRGVRQGDPLSCLIFDLAIEPLAAMLRNSTLQGFKILGVTERLIANLFADDTTVFLAATDDFQDLQLILNDWCAASTAKFNVNKTAIIPIGTAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FES9</accession>
    <name>A0A8H5FES9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FES9"/>
    <dbReference type="OrthoDB" id="2986789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="158"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="460" mass="49686" checksum="E365D466B93BF147" modified="2022-01-19" version="1">MIKDVSLPPVSDTEGIASSIGPVSLPNSDDEDGSDEDNELEEPVSEKISGKAAQKLIEELPVVSNKGLPASRAAGNKVKTVTATTETKAPSATQIDWVPRSDITLEAYKETTRSYKLCLKSQNSDIRGVINRARILGVIMLVSSIDSNKCPVSKNLRSVALTALVKAADQLGYDGEGDIADRLERGDILKYIKPMAKYTAGRISLERKLLKSPSSTVLAALKLDNSPRGRAAAGKLIQDGDYIYGLSSGKYDYQSPFQNEVMHKYMSDMFWGNNKLALLLRPYHNQLFVSSQPDDDKAKLELEIPGAMLVLSACAIHAILLDHSLGTNAKFPPVGLQRQWDGYVGIFENMKRRNKVRAHKILHGMYLKASHSIAPAAQGLSEDQIISRVNWDAFDEDVEEDGDVVDDEGSNHVEQEGNQDGEDGDAPGGEESGDKADKADKAGGDGSRAEDAGADGETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFD7</accession>
    <name>A0A8H5FFD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000260">
        <property type="protein sequence ID" value="KAF5334423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFD7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="135"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="341"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5334423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="678" mass="76017" checksum="67BE438B882DE796" modified="2022-01-19" version="1">MAWLFIGPTLESISFEWYIFLATCALVCAEAILTQLVFEHALRICMKSDTSDGSSKDKPTPETAISTSASPSIGSASEDNEHPHSHSSGASENATLHIAEETESTAVGTSRVPSPSLPTGPTTQAADDKKKPDAANLVGKMNNLVTSDLQSIVNARDFGMLIFYTPIQIVLCIIFLYIVLGWSSFVRLATIIIMFPIPGYLVKLVQRAQKDKMKKTDARIETVTETMNILRMVKMFGWERLMNERIAEKREEELRYIRWMRILDLTTMLVNQLHALLFWLNQSITAKVSLDRITNFLYNTELLDVYKQSTDGKIEEVPVTTNTTENNQDIGFCNATFTWSNDSEDSTMTPSCCRFQLHIERLLFKRGCINLIIRPTGCGKTSMLMVLLSEMHFVQTHPDSWYNLPRDKGVVYAAQESWVQNATIKENIVFRSEFDEERYKKVLYQCTLEQDLTLFEAGDATEVGDVKLAPLEKVLTLGGGQKARIMLARAVYSDAEIILLDDVLVALEYHAHIKADRRQTHNIILTQPIAEFVVSIKEGRVAIQGSVSDALVKNSTLVVEADHEQEELRIAEETIDAVPPVADAPKSDGKLIVVEEVEIGHIGWPALAIGLSESTENLQTWLQYEKMNPEDVNVVYYLGIYSLPLLCPFGSMADELLQLIVGHNSNFSSHYTLHQGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFE5</accession>
    <name>A0A8H5FFE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000252">
        <property type="protein sequence ID" value="KAF5334736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFE5"/>
    <dbReference type="OrthoDB" id="3261561at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="436"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="691" mass="78254" checksum="47196F8B8235083D" modified="2022-01-19" version="1">MGVTASLLNRLKKLVPAVIHTYIHNSSSVDAMVVCLPPSEFSRPPVDIKLDSNGKPTGTVPAAVVCKAHRPWWFTAELPDKATRLTEVISHFLFLDGKDNRFQTCGRRFLYDVLSHHVQQQEKIELVFPGFPFKSPSARKVLGRLPDLGEELLLHRLEALACAIEDDYAPGAIVRIVSDGIVYGELLGQSDANVYQYNSELRKICVENRLEHLTFVRLADLLQEGPLSANSNEMTLEEYVRDAPIIRSQFLAHDISHYNIEDSISKDSGVIRTYRGYLKFLELDLDGTSMMMDPDGNPLSGKQRDKVRRQLAKKMIVNGTKFSDLVQAKFPNCVRLSCHEHPNEGPKFALNLFPGSRMSATPWHNVIYEAADGHLQIGALQSFDKKNYEIVSKYGRPYYVREKSSVYSFGSQLDAQISFTRNFPFGLTVSCAPSAGLSFNDLPMDKLRKLTTMHSCVLLRGFSKVDRDDMTKKSEELGPILRWPAYGAIFELKENPNWDVNSSLTCEAMPMHYDGVFKTKTDEHGRITNDPPQFQVFQCIQAPGNQEGGQTILTNTADILRYGVTPSQRRLLSSKTWTVYTPQNTVFGGDHFKLPLITQNGLTGHDILRWHDPWPQWVTKFKATNVRISDSTREEEATIVDLLSDLLYDRRFCFAHTWETGDFLLADNVELLHARTAFVPSPRELWRVHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FH69</accession>
    <name>A0A8H5FH69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000227">
        <property type="protein sequence ID" value="KAF5336641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FH69"/>
    <dbReference type="OrthoDB" id="3058553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="757"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5336641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="892" mass="99888" checksum="08762DE884E95FB5" modified="2022-01-19" version="1">MAVITSSDNCALGPDGKLLDASQIVWDYDPDPTIVPPGTQTLSSPPSTSQTVRNAFDVLTSHGHAQAKTVAGQRKSTRTCRPTQKMLENNTPRGNGKRKASPSSERHPAACKVAKNPSRNKHSDDVTDLDISDVDMDALDDSESETDDKSEVQLLDYDTMKSFNAGEVLVAALSKASRTQDVYLIFEKAEHTNPDTNVTQSGHICGICRRKQLPAKTYFMTGSVTSLRKHIARNKDHFAVYKDLCEKKGVSMNATAIPASSNDLSRRTMLDSVVVKQPTVEFSTAGLRDYIVELVVLEDKALRFVTRPSFQHLLQFCRPAIRDKDFICDMTLWTEILQRAESVINIIKAKITGVSGKVSTTFDLWTSDPCDLYMSITAHYIWAPEDHPNDWTLECEQLEFAPFFGHHSGANQAAVLTKAFEKFGIDRNKLGWQTADNASNNDTTLQSIATIINQADEGSILDSDDTEFWNASEHCIRCMEHCVHLAAGAFTKGITPTSSSNITVPDPEQPEDNGNKDLDEIDEFAPGDVVGKVLALIRQICVSPQAHAYFRKCCISTNNRPLELRLWIRTRWASLHDALDRVIVLEKAIILFTQTADDNESVPKLKNKSYLDYRMSRVDWDHLKIVHKVLSLPAQATQSFSSSRHPTLSKTIPTLEYMPLLKGIENIDKWYNKVDDSPAYFITLVLNPTIKLAYVSGKWHSDWVQFDKYYIQPQQNTPSNPSSSSASTSEFGHGWMMAAIQDRLRADAAISSDPRTELRRYLESPLEPQPQGEDGKINEFDVIWWWGHHQDTYPTLSRMARDYLAIQGSATPSERAFSSAGLTDHKSRNRLKPKMFAAIQTLKAAYRNGHISAHQQASEHVKDLQKALEEYYFGEDEDSESEGEESSVIQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI78</accession>
    <name>A0A8H5FI78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI78"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="246" mass="27071" checksum="E0B9AC90A0D775D8" modified="2022-01-19" version="1">MSTPMLLTARILLSKQPHPTKTLSNHGRRVWVWETGVGASASMSSAVTVSSTPPTSAGTSSGFSCDGKGVWIRIRCLADQSEESEEQGWALREFEPGNGISLPLSDTPWKQWAMGPGFLIVYSEPGKEGSLNKFQDLYNWHKHGPLPLHHLESFLSDDTATFPCESYTFYTQTVHLAKLHLDESSLSSSLKSGNPTKYLVTHGITWGGDGESEKAAREWAETSVTELKKTEGWVTTRTFGVIAWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIE2</accession>
    <name>A0A8H5FIE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIE2"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175">
        <property type="entry name" value="BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175:SF4">
        <property type="entry name" value="BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034151880" description="Galactose oxidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="115578" checksum="8D91C9F17A74D5BF" modified="2022-01-19" version="1">MLRPHLLSIFLLQSLHLLVAAYTSPSRWGQAVAVINDALYVQGGMTDQYNSYSYTTAPINDDLLYLPLSSSFDPSSPPWQLLNSSSQGPVVAWHTMSAYNDSQLLTFGGLLGPDSTQVLPVRPDSAWLLDVSNRDSPVFTHEASSWANQPDRRMRHSAISNRNGQIFIVGGEKADGSQLALSDHYVFNPFSPNFTRLPSDNGPGGITGHASVILPNGTMLVFGGYDQPHNQMVPFSTIWTLDTTASSYFWTTFPVQSGNLPTPRRAFAYVLIEDGKILIQGGCSSDFQTMYSDGWILDLTQNPLTWTQVPSLSQVGQRRDHFAVSYGSEVIFGFGYGPSGPASAPLQVYNPSDGSYSSTYTPPSSPSQTQTIPVSTPTSSSGGGGGQSGSGNGEGGNGNGNGDGGGSGDGDGNGNGDGNGNGGGSPQNPDNSNNNGRTTAIAVGTTLGVLGALIVAVVVIYYVRRNRLADEESRFMLLHGNDMDEDGRGVNPHLEEELRSTHALGEKHPLSQMFKNFTFAGALTAVPAGVVAFTKRRAPERERRDMLADEDTREFAPWYAFRRGSSWSLRSAMRLRSREPSIGSYYNISNPPTPWAEKNDPFSDGAAVMRDGETGYIGAAAPGHGGIWRSSNRRDRDMSYGSTGTDYSYTDPFADPYADSGVEPGSHGSHTFNDEETSRRPYPRPAQPLQIDTLLPVSVNAHTLSPVTEASRGTISQSSQSQSQHSPSVSSHTNSNEQSGTLSPFDTFSPRTSSISSYSQHRPSSLIDSANINYFGGKPVRRSDSWWNRFSKTSLLDRRGSGSRHGYGGMPEIRDPNPPPRLVAIEESQHSASPENGSPNSAGSNSIKRALSKRSSKLYRGGQHGKSLSSLRTADSDAIERMAAMDVAQRERTGSHGTRDSSGVSADNNAEMWLPEDGRGDVEIPFDVTSPTQMTRAEAALAPVASSLRSKVSTSSAATSSLYKTTPSPPASIPTPPSAASGRSGSSVSPSQSARRSRRMSGDAVAARVRAFEQMSMDTDDSGAGPSTGAHPQSKETPGTGAGADRKRKVSSINYGLVPRPSLFVANPDHSQMASGDSKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKV9</accession>
    <name>A0A8H5FKV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKV9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="25807" checksum="CFF343431CB0C00B" modified="2022-01-19" version="1">MEFLQLDGQTFDQLLACGSIAGVDDSSGLEDQTVEDTTARYSIGKRKRDEQEGVQERPAQLRRSSRAATTSQRRSSDLTVYHFVKSPSHSRFSPSQDPEPMQQQRNMSSDDQEIVRLREENINLQPEIVAWLKRCCDDEGESETDNEQFRDEYKEREAQLKENIVRLEENIEDLQQDIQAYKSQQASLIWNTTVDIVTISVIGSLLHRSICQYFEDRTLPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL74</accession>
    <name>A0A8H5FL74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL74"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="2">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="520" mass="59452" checksum="2C1014E95971F336" modified="2022-01-19" version="1">MQLDTWTCNCGQQKYNSHCLCKHLVQAVGEPDLHFFQQVIRWRVHPFYKHPQLVPKGEPHRSFSTAEDGSFTDGDDQDWLGDHSQLTGGAWREFSSGLKCCRSSAFSSTPTTRSPSPQSSRPIPPINNVDYGSENEHEALDVIPEHRELAGRILDEAYEEVEEELIETLNKQNVTMTDGWKDISCNSIAGVNVSASFQPYLIELRKTNKDKKDAVSFCEAYEDMIDCTEVKYKCNVIAFTTDNDGGGGGAGHKLLVKKRPWLLGTPCTAHQCQLVLGDYFKENKEAAAHDIFDQTQLEKSPELSEPLAYIMANLTCWTTHFCSFDRLRDLKDPLQHAAFLKRRDIIAAQVGAEKNNRKKQEMEDSVNKQCDLIMDNTFWNGLGSVVEDIEPICYAVNICQTKDGMKKQLEKRWKSYDQEFFMFAMVLNPFEWLDQFREAAKIGIWTLLEYFKKFYQHVNSCPPHSSLTDEQLAEFNLAKEKSEVDVAKAFMQYMSWTGDFHDFKANKDTVQKTFVHSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNW1</accession>
    <name>A0A8H5FNW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNW1"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="215"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="916" mass="97289" checksum="979F14AB6B48F9FE" modified="2022-01-19" version="1">MMAGRLDIEKSHSGSCNLAPVLFGSVLQDYVFLSLPTCLLHCPGSAMSQVKLTLRPPPNVDFVHGYPGIPPGAPIDLKLQSKATGAQGVKAKWVRVELRKVETLPGGGTTNTFYDFVGPSPVTLWTSSDEYAVLRSQDFPFSIRIPESIPPSIALENRGITNSTLVSALKAREVFLRRRKSAVTSSQTAVIIDKHELHSTWPIYCQPETRQITQDGVTLTVDRNHTCYGPGDRISVMATLKSDSLHAILLRGFELTLKESTIFRAGPYTSGKKSVPQVRVAVVSESKLPVNFNLYGGMVQKAELTCAVSPNHTTTTLNTARHIDITYVLSVKAQLGAGQPIVMDLPIIISNWQRNVSQEAIRRIGPAPSLSLVPGNTQSSSPASMHVEPAPGRSPHPSEAQTFSGVSSQPDYSRSGASASTYTPSSRVPNTPRADEFGSKLTKATSVDDIASKYSSTDGGRRPGSAGTSGAQSKFSVANAADISRGTPGRQPSAGASGNTANAPSRAWLSAEREKELLYEAARLEVEKTQKEAAAANASAAATTPPANRTQSSSREWESAEAEKLRLYNSAREAVNDLQGRNVYVPPQPQPTKPTSSGGASFRSDAGFKQASGGPHYPSAEAEKEALRRYNEAKEAVTRTQNAGFVVNEGSSSIAPPPANDLPPPFEATPPSVVDARSALAEKEKLRRAYEAQDAAAAAAAANANQPDYSQAPAYSSPPPFPGGSIQDAISEKERLRRQFEQQDAMAMAAANRNTPPRNTPSPAQSRARPTPATPSAGGSRQLTAIEEKALLRARYEAEGSSTPPPQVNGYSNGGVNGVNGVNSSFTSSSSAPPPLMPRPPAEYIQETQEEDARVSRYVNGALPDNGPIPPLPSTPASLSRSNSGVLDMRPFTPFSTDFNASAPNGNPPLPSKPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNX9</accession>
    <name>A0A8H5FNX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNX9"/>
    <dbReference type="OrthoDB" id="3064914at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="582" mass="65051" checksum="CBD781504619DC23" modified="2022-01-19" version="1">MDFNTDTFLELLPYTFKILQKPLGVHARSRFQDPSFLNAFEILAHGLYSTSSGFSSNLPDEILPMLEENLERVWALCIAVLERAVLPGTEEGFWSAGPVRSALLVVSVLLFEVQIRRLQMKAKQQRASTGTITPFPSNESFVTCSMQATGLYVLLKDVFLCSCSRAKGLSSHTATALVGASDIACPAALETLRSILANSDMIKNIRQALIPLNKDDIHPEDVVRINSYVKLLQLCTKEDLPNFHETSHRTILVLIADILHNMFSLRTLCNISTATFQSDDDVMPALLDNGVIIADSLARFIATDHSIVVPLLEEGMFVTMLRIVSFLRNAERGNRISNTLQRDTLEIKLGLVVKRIAAAMVFRHIECTVKKWLKLLKDLEMGLQARGLGLGILWKEWVALRSLIKKGRKRRHWRKEAWGLAKNICSNPSCTDSSDSSPEAGKRKLCTNCMVHVYCSPSCQAEHWDHDHRRECRVLASEQQSLGLAPLSAYDIRYIQTNLAYAILREHKRAIKKMRAALARATPNADQMIVVDYCISPPDVSVQNMPQPSALPEMRAVVPHGRSGRVEVPLSRDVLAEISSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPU9</accession>
    <name>A0A8H5FPU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPU9"/>
    <dbReference type="OrthoDB" id="3020010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="103" mass="12353" checksum="1063CA649CF36232" modified="2022-01-19" version="1">MSYWNSIRDKFENSSNTLDKYAFKEMLILRIKLILLGTLRYLDLVVEGTMNSFLGWKLPSVTVQKHAKDPRSVEEEKEARREYVGNMKMHYGKEKEISWLWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRN0</accession>
    <name>A0A8H5FRN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRN0"/>
    <dbReference type="OrthoDB" id="3352225at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053099">
        <property type="entry name" value="WAS/WASL-interacting_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48226">
        <property type="entry name" value="OS06G0326200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48226:SF1">
        <property type="entry name" value="WAS_WASL-INTERACTING PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="286"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="686"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="981" mass="103067" checksum="E5405A0A8BF79CEF" modified="2022-01-19" version="1">MTPAPWLGPGSSLPPQGYDPSNQWAPSSPMPAQPGFIPPEPRNHVPPGGGGTPLPSNVNVEFMGGYPNFAPTLFAGSDSLPAGGDGGMSGGYPGMTPFEAPMSSPWSTPRMGMDGMGMGTSYMGAGMGMGRMAGSVGGGMPGMGGAMGGMGGMGMGGMPGGMGMGMGGGMPGMGGGMGGMGGMGGMGGGMGGMGSMGSGMGGGMAPSAPAPGPFSFGQMAGTLDYLYPSSRLTGSAGDHLPPFTAGPGYGPVLTPLQLSILGVLPILNPLLAPPSELETNKTNPYLKWNLLFSSAMCQRSDDPPNVSWSQGRADPATFPRVTSLTLIPSTHSAAHLPFMVTINASNPDVGVTCGDIVESLSQALYSHTSQSVFMILTSRRKEVVTRAYHFNRSRSPGVPGGVLGKGMRRIDLLGSEGCWGGMKEIEGMREVGLYISNQRKALMDLNNVMNPGGGVAAAAAVVKPEGITKRADELPWCTYEWYNLTSYPMTQEEARVLEERQQMVEREHRKEGKQRVREEGEHSRDGRIHVLSRADREWGGIEVQPSTGGTASGRATPSQAPSSRPLSTATATSITPTLVLNIAPKPLQSNVNVEFMGRYPDFAPTPFVGSAMLPAGGQMAETLHSLHPSSRLTGSTGDRLPPFTAGPGYGPVLTPLQLSILGVLPILNPLLAPPSELETNRANPYLKWNLLFSSAMCQHSDDPPNVSWSQGRADPATFPRVTSLTLIPSTRSAAHLPFTVTINASNPDVGVTCGDIVESLSQALYSRTSQSVFGILTSWRKQVVARAYRFNRSRSPGVPGVVLGEGMRKIDLLGGEGCWGGMKEIEGMREVGVYISNQRKALMGLSNATNPGGGVAASTAVVKPEGITKKVDELPWCTYEWYNLPTTQEARILEERQQMVERQHREEEERRVHSSSRDGRRHVLSRADREQGGIEVQLSVGGTASGGAAPSQAPSSRPLSTATATSITPTLALSMAPPRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTP0</accession>
    <name>A0A8H5FTP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTP0"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="35354" checksum="38395EF8416E8D93" modified="2022-01-19" version="1">MSKADEETIPLSYKYHWSQDSEMPLKDFLAKYRPSMVQNDGTKPWIWVSPPNKDDEHRSSRGEDQAIEEGCKLLEEVTARVEEIKNDSSIPARSSKKTGAKGKKEIREQVQAEATEKLKEIALEHDYVVGKWLLFAPQAKVDAIWSDLATSLVEGPLAKTKAFRAKVATSPPSETPNYQHVMCLYIPNVYDKDTVTSIMKILLRNHGFNLSGVKSDLYTLIGLDSKHPSGIQSTELKEQYFAELMSNKSSAETSETTGDVSEKSNEPSAAKAKSKPKPKKKNDPFESDDDDKDDGAKKRAKDSDDEEEQPKKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVA4</accession>
    <name>A0A8H5FVA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVA4"/>
    <dbReference type="OrthoDB" id="3236755at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="584" mass="66356" checksum="AA7D3C02AC82860B" modified="2022-01-19" version="1">MLEDDLIPSEAAKIVSNNMKLLKTERNLTISFDGGTRRRKSHWTVHISEQNRSVHLMEVKNATNERHTKEWVRDLALRWMREIGETQFCAVVSDSTGNTLSARLLLANEIPTLLALADICHHCNNTSKDIVKIVYFEKAIKVVRATLQKFHQSNHAGFLLDCASQAQLQRIQGLEAIGKTRFSTITFSALSVQRNSPAIKAVVESGDESLEDWVTLDTYKHEVQTDILRQEHAAVFQTSPTRASQEFEFVLKQLIDVGLPLARALACLEANDANPADIFLYWHAVVFEIERLVTDKKKDYPKEVQDEILHILDHRHSQLFTPGGRLYNCVYLATAHVNPSYLRSQLFQNNNPDPTQPLDEKTYPPLQGIRHHKILWPVAHFLFDIACKEVKHGSNDVFTKWNEHGKEFLEQFRGEMQAYAWSSYPFNAPIDNEVSTEGMSPSSWSLFASILWLTKGQAQTHLDDACIVQQNPKLRRKRVKFCDIKKDFEDPGTRIDEEDDSWLDERDTDSEADGKNTIASDEYVGVACSFITAANVVNPDAFEIIFLLKDSAVQKVCLAKTAEVGGPRGPRDLEFVLWPVTKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0F6</accession>
    <name>A0A8H5G0F6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0F6"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5355527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="35569" checksum="98270E75F3AE0584" modified="2022-01-19" version="1">MAPFDLDACISQLLRKQLLHEALLREICEKTKEVLMRESNVVHISAPVTVVGDIHGQFYDLIEIFRIGGYAPHTNYLFLGDYVDRGLFSVETISLLTCLKLRYPDRVQLIRGNHESRAVTQTYGFYTECMRKYGSSHVWTYFTDMFDFLTMSVVIDDRIFCVHGGLSPSIHSIDQIKVVDRFREIPHDGPMADLVWSDPDPEKEDFAISPRGAGYTFGSGVVHKFLEINKMSHILRAHQLCMEGYASLFDKHLSTVWSAPNYCYRCGNSASILEVGPGESMYFNVFEAAPENERDGPAQQAAQNAGGKLPEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7X5</accession>
    <name>A0A8H5G7X5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7X5"/>
    <dbReference type="OrthoDB" id="3060222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="36761" checksum="B6EED1FA7EC15F6E" modified="2022-01-19" version="1">MSSSAASNMSSTASAPHGPSPPILDYVQRSPGAGKADDDVEKRRFNIRVESVHYELVKSKDNEYPDRKQCAVLLKTTFSLMDKDKLASAKVPFLISASAGTVTTTSGEDGVSIVQIYRHYPDHHEFYAAETITGNQQTNVEPSIKVGSGSGPGIEVGGVGTHWQHSFSNVKRISLRSEMQGQDFVRWIYDNPEGVYYPREVKLLLIVQRGHKEDDSESASFPFQLILQPALSVDLYDHIPRKMWNAFRRYVGKDRNHRGWKFELKGPFKPALARDAELEADRFEDTQAGTSSEQTKSGTFIPTRYGLHAAAKSWREENGISLGMVSISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Y3</accession>
    <name>A0A8H5G7Y3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Y3"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="21213" checksum="B257B150F8075140" modified="2022-01-19" version="1">MQKVYITQVRMVSIQTITPTKPPTGSSFSNADGESCQQAKTEPLIIAKAKKEEEEAAKKKANAKAEKAKKKAEEEVRKATEEAAKNTQEGGTNTTTVVNMEDGEGVEMKEQKITIAASASTSAAHKLLTGDDDVKADTRNVSDDMLELDPLQDAVDASEEDSIFLGLKVYTKKEVSVMITGQLRHELEVSAKLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G887</accession>
    <name>A0A8H5G887_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G887"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="75"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="579" mass="61744" checksum="4F9422A384A00BE2" modified="2022-01-19" version="1">MLRGRERAEPSKANTSKSNGPPKVAIRTCETAVGPSASFTVLTSTMSHLDIANVRSSFPALSSKSKLSTNGVPYVFADNAGGSQVLGSVVLKISDYLVNSNVQFGADYSVSQIATKRVFEEAQETVRLMFGFDEGAGEVVWSSSTTLSFENLARSMALGGKIKAGDEVIVTANVGPWKKLAARVGATVKMWSHSPIPTSTGKPNPFSIALTVDGLLPLITPKTRLIAFTACSNILGSAVPVADIVKAARKKMAEFGPELTLEVVVDCVAYAPHMRMDVKAWDVDYCAFSWYKVYGPHISSMYIRKSILGSSTSGSSAVPPYAASITPKQQSSAAASDAPSKSQLSPLVHHFLYSKYADSALKLQPGSPGYEIVYATTAVVEYLCRLSSGLKEDETAEDVSEPGVPLSIPALDSSFSLIQAHDKALALPLLQFLTSDAAYDVGVRVVGDEGLLPDGSVKEGRAPTISFVVIDTTYTSISTTNLRKKLWSKSLVHAVDQAGGIGIRYGHFYAYDLGKSFGLLPPTPNNPGPNGEGQDGFETEEEALEASLEDGAVRVSLVHYNTVEEVERILGILRKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8F9</accession>
    <name>A0A8H5G8F9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8F9"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16236" checksum="C31CA185EC69975C" modified="2022-01-19" version="1">MVRYATRISKTITKSTPAPGKQSHSKPLHKFIIDYSIPLAYKVFDADLYEKFLHDYIKVDEKPGQLGDSVKIVRDAKSDKITIATTIHFSKRYLKYLTKKFLKKQGTRGGVRVISIAKDTYQLRFRKGMMDDDEQEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA62</accession>
    <name>A0A8H5GA62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA62"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5361139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="37084" checksum="AC234D8E5FBEA6E0" modified="2022-01-19" version="1">MSTTTYESIQFRGSPSGEVVQKTYTYDGLAPNEVIIKVTASGLCFTDIHMLNSDMVLGHEGVGIVQAVGSGCKTVKVGDRVGWGYTNSCCEKCEFCLGQDDSYCKQVEWYGMANQDCGSLSSIAKRKEEWLFKIPSEMTDIDAAPLMCGGATVWSPIIRNCKCFDRVGIIGIGGLGHLAIQLLRKMGCDVVVFSTDASKRDEALSLGANEFHVVKGLQKDYGELDIKPVDRMLISTSAKIPMGQFYPIMKPRSTIIPLTVDQGDLTVPYTQHVLTGMTLQGSAISPRLEQQKMLDFAARNEIHVMAEKFPLTLKGVNEAVEKLKSGKMRYRGVLIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAG8</accession>
    <name>A0A8H5GAG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prephenate/arogenate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAG8"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="522" mass="57559" checksum="020FF8FEA7EA9CAD" modified="2022-01-19" version="1">MAASSRFSPAIRPEDAADSQPTLGIIGMGAMGKMYATLLAKAGWKKIHVCDLPSKYEALRRECANAPNVTVMKDGHAVARSSDFMMYSVEAEFIDRVVAEYGPSTKMGAIVSGQTSVKAPEKDAFEKYLPEDAEIVSCHSLHGPTVSPLGQPLILIKHRASDESLQLVEQLFRSFGSRYVYLSYEEHDLVTANTQAVTHAAFLSMGTAWASAKLYPWEQGLYVGGMETVKVNLALRIYSNLWHVYAGLAILNPKAREQIDQYATSVTELYKLMVEAGNKSSNSSSGFTDADVGVGKGNEGGEGDNNDVNRNGKANGDLEKEKKLRERVEWAKDKVFGSGDSSKTNRKPILLSQEILDKFSLGKRPRASSSPSSPSSDTSNGTQPTNNAYTPNSHLSLLAMVDCWAHLSINPFDHLTLAATPLFRLFLGVAEHLFLSPSLLDSAIRSAIYDTWHRSDDLEFVVAARGWSQCVRFGIFEVYRKRFEETREFFEGRFEEAGRLGSDMIKEVMKSEIEGDVSRSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAL9</accession>
    <name>A0A8H5GAL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAL9"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="88" mass="9438" checksum="8C88F39D9D35442B" modified="2022-01-19" version="1">MLYPNCYPDLIIHRASFLNYVNAFPADAARFGIQNFAPQLLGGVPDILVAGPNVGSIHSITWGTLSKSREQSFSGSGSSLSFVSYTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAW9</accession>
    <name>A0A8H5GAW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAW9"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="71"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="716"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="985" mass="107510" checksum="C6927C4449F7F510" modified="2022-01-19" version="1">MDFFAAKAESATPGDDVDGFAQAIADRFKHSPVFTANLNAPLPNKLSAPSNILPPETFKSISPKDIQPYLDDPSTLFIDIRSHAAYASTRLPNALSLSVPSTLLKRPLFPLERLATMLPSLSARNRFKKWRQTSKLVVYDADSSGTQSGHLPEGNNILGLLRKFASDSDSAYKGQLLWLKGGFQGVWKECRDLVDTRPVDPDADDDETSSTSLRPNNLPMSAFGSSSTTVNKSGLTASSLRPNFVRSAQPLPAMAFNPFFDTIRQNVELSQGITERIPLKVSKRVRRRLRDLPFNWLREIGRRADIKADNDSSDDDSLSESPDRLSSVFFPSSESLLTSSSSGESSCSPPDRALVDEGMEALAMQFYRIELAEQKRLMGVMQHHTKESGTQSKSGPGLSSSSMRLDGPLSSLGPQTSPDSPFPYSITAGIEKGAKNRYRHIWPFEHARVRLHKEPSPRQSRPQISPTHSTFSHTHNSNDISLNLNSNLNPSGSSLHNQTPQNFNSSSSSHSSSLFEPTPASSSTTSSPSTSMRPPPPSGPLSGPGRPFTLSLPSSYSSSLSASRPYAPPGSPKKSVLSSSASGSPVRRSTTRSPRPNARGLKLDLGLGGDGRFANGAQTFGRSAVAFGGAGRFGGVGSSGSASTNGSGMQMSSTEPRFTQMRGGHGSGGSGGESAIESSATESEREHEFEDGYQSMSASTSTGQHIGSGMEGKRYGSPEYDDYVNASYVQPLCTTRRYIATQGPLEATFTDFWTIVYQQNVHVIVMLTREIEGSMVKCGSYWKDEVYGSLRLKLIDVRGSEDDARTDMRKTDTAGQHSQQTQGHLGPSGFKHDSIKDEGSFSFFPTIKTEEEENKKREKGRRKGKQREERKERRQRAKEEDVEMDVNTAGAGASDSGSGSSSRKDKSKPKHWIPSKHKSIIKRTFLLSHTGYPHIPPRKVVQFQYLGWPDMNVPEHPTGLLSLINQVDKAVEAADISLEKHWKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB96</accession>
    <name>A0A8H5GB96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB96"/>
    <dbReference type="OrthoDB" id="3270420at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="394" mass="42555" checksum="5070E5429AFE3A8B" modified="2022-01-19" version="1">MMADSAGSVDITVVGQPNHLAKTLDAGEVDTQVHSPCSLSLGDTVYTTSELDNESNNGITITEPSVQDAAETIATVSIPQNHFDDLSVDQIKASSLLVATQCDPDSGRNITHVLQPEVFPQATTNGNNASANDPEQTVTSSPILRPHRTIRFRSRVRITSGVGKNHARHARRSSSDAGSASDIATSRAHLRSLTSLSPDWGGILPSGADSPRDSSTGATSRSNSVSSSISAPIRFREDEENSSGRPSKWGPLGRRVQMFVGQQKAAKQQKTQPANESGKGKRVILVYDPETWSYVPRAQSIPQNSSRDPDVHSEVSPLLGRGYRSYRARRFPSSGSNSSGGGSYDSHDGRYDSDNGWGPDTYEARLNQEIEKVFGTWPGRLLNRHVRADVLSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDN9</accession>
    <name>A0A8H5GDN9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDN9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10379" checksum="8A463B3127244985" modified="2022-01-19" version="1">MSTSTGIVGKDKGDDWDGYEDGFEDNDEDAWRTEWGLVPREMLSEFRTPREEVVGTYSNKGNGKGKGEDEEGEEEGTEKEWGIQGRWSILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GII3</accession>
    <name>A0A8H5GII3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GII3"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="819" mass="89440" checksum="9604FE412DA8E144" modified="2022-01-19" version="1">MAQPAFDRRRINGPEESSPPVFETEDLPKFKPLRDTRESKDIRPIFLQPGLIFQSNGSAYIETERNENCLYGPRQSKNTAYSEKGRLNVEVKFAPFSCEHRRAPMRDAEDRSVAVAVQQALLSSVRLELLPKSTIDVFIVVIEADGIEACIASASVAASTALANAGIEMLGLVVSCAACALDKDIWLDPTQEEALQAHGVLVFSCIPALGKVTSIWESGQMKPSEIMACLDQVLAPNERTFCTWNIFVVLVDTNIHQHSPLNDNHSHSPQISPRPSRDSDDSLRALEISETPLAETPRHNRNRSYSISGFEFHQDLLPLTSSLAEPDILHNESGEKNIGLLNGIALIVGLQIGSGIFSSPGVVVTNVNSVGASLAVWLASGVLGWTGASSFAELGSAIPQNGGAQAYLSYSYGPLISYLFAWTAIIALKPGGNAVISLIFSEYLNRIFWHTTRADASPDDIPEWSVKLVAVIAVMVVSGICIWTRKLGPRVQVVFTTVKIASLLMITILGIIQLARGKASRSLREPWFEGSSKSPSSYSLALYSGLWAFDGWDQANYVGGEIHHPEKNIPRAIHSSMALVTALFLLANISYFVVLDKAIVGLSNTVAMDFGRALWGPIGGTVFAFMVAFSCFGALNGSFFTASRLIYAAGRERYLPALFGRLHSRRKTPINATLLQTGITTGFILIGGGFRSLINFSVVASWAFYFLTVLGLVILRVKEPMLERPYKTWITTPLIFCAVALFLLFMPIMAAPLEAMAVLGFVLAGVPVYYITHRSEQNFSWFSRGIARLQGRPSAGEGWEAVASDEPIEMSEDRVSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ03</accession>
    <name>A0A8H5GJ03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="424"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="740"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="814"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="925"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1182"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1329" mass="148649" checksum="882686AF4DAA8417" modified="2022-01-19" version="1">MRNLSLASIKTLSVGPNVNICCTTIDLDQNVLYAASERVTPDGVEVEIEVWKIDGDLHETNLLTMFSTMASPQNVSSPQVISLRFIPDCQGLVVVTRGGDITMISSESEEPTTEVQGTVDDGILAASWGPDDTLLVLVTAVGKLILMTSTFDVLSEAPVETADFGEDAPINVGWGSKQTQFHGSLGKAAAQAPSNVVVGSSPDDDNIPRISWRGDGAYFVISSLTLEFAGHVHRVLRVYDRQAALQSTSESVPGLEHSLSWRPSGNLIASTQRFGFEGGGAGRPGRHDLVFFERNGLRHGEFELRPADMTLSPESEGAKKWGYRVKEVGWASDSNVLSVWIERDEGDLVQLWTTGNYHWYLKQEISATSKSSHPVHFTSVGWHPENALQLILTTSTEIIHRTYAWETIVSPSKPPVDSGLVSITDGCKLLLTPFRTQNIPPPMSSLQLALTPSTQPQYPNFASRVPISSCFTASSDAIGVLWEEGSVEIWELNTRLSPERGSALSPKKLYSWTVDPQDLNNPRFRQLLLVDSDTSSGTMTGILLGSTANGKDCLVIAIFDGEKVQVHSCQSTEMTSRNARLVVLGPNGVIVWQGTDGCICQVELADSRVTPLCRFPEFCFTAQQIVTNDSSLYIGLTDSGKLYVASQDKSTRVLASNATSFTVASGYLTYTTGAHEAIFAPLNDLPDLLIQDEEGNLKDIPSDWEKRRVERGSRIVVSVPSAMSLVLQMPRGNLETINPRPLVLEVVRQDLDMGQYRKAFLACRKHRIDLNFLVKHNQVAFLQNLSAFVEQVHEVDHINLFLTSIGRGSQVPETITKICDSLRKELEKRDLKTYVNSILTAHVIKTPPDHEAGLSLLLRLKDTEPNLVEEAVKYIIFLVDADKLFDTALGMYDFSLVLLIAQHSQKDPREYLPFLRELRALDQYYQRFRIDDHLRRYTSALRNLSLAGPSYFDEATEYVERYQLYETALSIWKETERYKTILDIYGTWLFERKEFRQAASVFVEAGNFPKAMVSYERSLDWQDLFDLALQVGTSEDDILDIGYRVSEELTSKKRHSEAARVLLDYVRDVRTAVITLVQGNEFSEARRITTFNRVSELVEEVIHPGALESRAQISEDLGEMKEQIRKQVNRIRELRVKKIEDPDEFYGVEDTALHDVDVMTDVSMAPTAFTRYTVAPSTASRTSKRSSRSKRKLERKIGSGRKGTVDEEEYLLKSVSKLVGRFSVTRTEGSRLLPHLLQFTPEHRTEGLAMQQELADFETELSAAVEEIWAVPADRSGSASEAAPLDSWAARMEEAEKNRRINPIERVQKPELSADRESWKLKLFELERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJI6</accession>
    <name>A0A8H5GJI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJI6"/>
    <dbReference type="OrthoDB" id="2142724at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="51"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="19303" checksum="1807844F7764D222" modified="2022-01-19" version="1">MGTRMCTATAGTMRVPFAGISLKRVQRIAKEQSPKKVAEFICRAAEFCPTQLVSIDEMSKDDRTYARLFGRGPVGARVENLVPFVQKRRLSLLAAVALDEGIIASQVIEGSYTHDEFLQFLEEDLLPEMNPYPGPRSVVMMDNARIHHSEEVTELIESYGMFTYLFTINGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJT7</accession>
    <name>A0A8H5GJT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJT7"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="337" mass="38848" checksum="A80CB5DB085BDD46" modified="2022-01-19" version="1">MFDCILHRNEKCKAMKRKERSDEIDSQIREDSIRRKRRSGPWKEWRVVVLGAEGSGRSTIFKQMRIMHQGGYSEEERRMYRSDIFQHVLRSVEDVLSVIHELGLAYAEEDPLVKYVSEHSPTEDPASLSSELVSGTDRFWHDQLVKSVVEQHGSWGDHFEDNGHHFLSQITRIGSPDYVPTDQDILLARTSKTGTIMETTFSIEEQPIYLYALVRNNSLLYRNSPLDFFDSMTSAIFCVSLSDYDKVKGGGEAEKQNRLADSLALWKGIVNSPLFYPCCLILFLNKLDVFRRKLPKVPLEAYFPDYIGGNDVTKAATYILDEFKRASQTRRTVVYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKT9</accession>
    <name>A0A8H5GKT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKT9"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="572" mass="62301" checksum="564742EFD32D3D14" modified="2022-01-19" version="1">MFSRKRSSLIPVPLILAASLSTSRTTYSGSLVAGHLTSSSGYPVADFDSKCSSIASQLNSSISNATVRFAELVTQGTNITFTDSDRDPSCVIEPFFLPASLIVPADVCRISLDVQTSGRSGIHMETWLPRNWTGRFLSTGNGGVGGCIQFPDMAYTSSLGFATVGTNNGHDGFSGQSFLNNSDVLEDFVYRSIHTGVVVGKEITKTFYGHEHTKSYYIGCSTGGRQGLKSIQDFPEDFDGVVAGAPGNQWNKLMDDFSHTFNLTGTPDAPSFVPAEAWVNIVNPDILKQCDTIDGVEDGVIEDPHLCNYAPSPNIICSEDSKATRCITPEQADTVRKVFSPFFIGDEFIYPRLVPGSEISDALSMVLAGDVATFSTEWFKFVVNSDPNLDVKTLGPSDWKKCIAQDPFNISTFKGDISAFKNRGGKLLSYHGQADSLVSPENSEIYYDHVSSTMDLSTSQMDEFYRLFRVSGMFHCFTGPGAWNVGQGLFGDTSPGSDYTDPEKNVLMATVRWVEEGTAPETIEGTKFVNDTNSLGVEISRKHCRFPLRNTYDGMGDSTKPESWSCQPVSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL80</accession>
    <name>A0A8H5GL80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL80"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="83"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123833" checksum="346979F38E2AACD4" modified="2022-01-19" version="1">MKAHTINLTQRKQKAVSNGIIGRSIFAYSDRKSIAGRLKRASGRNTGLHTREKTAMTTPHVIASSSPHPSQSTTASGIVGSHYRVGKKIGEGSFGVVFEGTKLLSNIPVAIKFEPRKSDAPQLRDEFRSYRTLNGTPGVPQVHHFGQEGLHNVLVIDLLGPNLEDLFDMCGRKFSIKTVCMAAKQMVTRVQAIHDKSLIYRDIKPDNFLIDFGMAKHYRDPKTKVHIPYRERKSLSGTARYMSINTHLGREQARRDDLESLGHVFMYFLRGGLPWQGLRAATNKQKYEKIGEKKQSTPIAELCEGFPEEFSIYMNYVRKLGFEETPDYDFLRELFTKVLKTLDEKEDGVFDWMLLNGGKGWEAGNNPSSNTLVQAHANASSPHGERREHRRDREHGGHRRGSRQAQDASNSSPLVVSPAPAHVKGSRRQGQERNNSSRDIGSVQPLAPTSRRASQQQQREAGALASVGLSTPHPYATAPSPNGYRTSTYDRNSPNPANNMISNGNAAHVNGSDSFLYGQMPGKNGTNSRDPTLTGGTGTAPSPGAVRAMNMYDRDQIGRVGEQDEDGGHGRRRGFWSLLIDSRPTLESVLVFNLPVNNVIMQWDSSTPREVAEDLSRAADALEIMQASGELIPQVAISDTGSPTIPPAMFGAGGPMLKRFDESTVVSRKGSRAPTPPPAVKGIGKKVAKPDYSEQKIVVAMVGLPARGKSYLSNKLMIYLRAVRVQNRTTGLQCGTIKANEGKTKSAAVGFIDSGCSVVGRIGRLTLVDRLGIKEDHTAAFFSHDNPDATLSRDKLAEDSLEMLIKWLKEGGNVGIHAFLCRCNEQYEESQARSLYFGCQHWSDIFYRDKLKTRVDKEKGLTLIFLESLCDDPAVIAANVALKVSQGDPDYKDMSPEDAKRDFLKRIREYEKVYETITEPDLSYLRIMNVGEAVTMSRINGYLQSRIAFYLMNLHIKPRNIFFSRHGESQYNVEGKIGGDSLLSSRGMQYAKALPALITDNIGDKPLTVWTSTLKRTIQTAQYLPYHKLTWKSLDELDAGVCDGMTYEEIEQAYPDDYANRDEDKFNYRYRGGESYRDVVVRLEPVIMELERQENILIIGHQYRRSMQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL87</accession>
    <name>A0A8H5GL87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL87"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33099" checksum="E66E95235DF110D2" modified="2022-01-19" version="1">MIPLLRSDKLSPSGQRAVFSSLFTNSFTIGAAVLAHSIRRVGVNATLVLLHLDEGLSPKALCITQAAGWTNHPVSLLPPPHDGKGVDWRFVEAFTKLKIWSVGEELGIDSGVFLDADTLVLRDFDEFFSIQWEFGAVPDVYRDERKFASTFNTGVMAFRPSKHTLEDMKDKIETAVYPPNEGDQSFLNMYFGSKAVRLPYAYNANMAIKERSLEVWAELKDTMRILHYTAIKPFWDKSVPKHKLFTPEQVREINDVRAGKDGGIYREEVGWWRENFEDLMQEKGAAIRGCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLE3</accession>
    <name>A0A8H5GLE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLE3"/>
    <dbReference type="OrthoDB" id="2953081at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="24250" checksum="0BEB9AA97593230E" modified="2022-01-19" version="1">MNAPSTITIQEEQPDNPIARNALERALLKLPAGTVVSSTFFPSDEEMNEKICRDYASIITIGVTRLSGTSDNPEETNLIVVGLKPTKGDKTPIWTIPIPHTVPAQFIRLWDGGMRNYGLFCLDFVDSDDVLVSLPEGCKLIPDGWPQESALRSWEEGYSRGHPENPVVPGTEWFGIPSDVSCRLVRDGLEDLWFHTPHIPNHQHHQAVRMTMRRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP07</accession>
    <name>A0A8H5GP07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP07"/>
    <dbReference type="OrthoDB" id="3056922at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="590" mass="66650" checksum="24B7AB2A8A937B97" modified="2022-01-19" version="1">MASPQIPVIQCYQCGAALSKVPFTVPDPRILEPSSAILAQIRSKYIPAETEMGNIAIRIEEARRAIHEREKEIRWLRPTLEKLESERDDLQRYLESYSTLSSPIRKLPAEILTEILSYSSTLIIGDGVQCRTLDYSQVCSYWRQLVSSCSQLWSTLQIDLYDVDAETLLLMKHYIAKSNASPLTLHISNLGGDAASEPDEESWLSDSEYQAQERVTVNALRAFTVLLHQSHRWRHLSLDVRASFFETFAADPEFSCCDVPFPILEAFNLINGPVASLGTDCELVSALQRAPRLQSLHFPEVYLKMSSLNSYAPPFSQITILHICCNEDLDIYTLLPRCPRLRTLEIDHGKRLVLPSVPVVHESLRDLTLYFPNYSHLSLVFEEITLPKLVSLTLSSSTVPHTQAGALYAPSLQQWLPDDFLVFLSRSACSLRSLSLGTFEILGIQLHRILRVTPDLTHLSVKEYHVSFDPSLLLALTLSTSPDSTPPALLPKLTDLEVEWHEYKHQPEDVLKLVSMVESRSLGRSSISNLSADTVVCMNKFSFRYSPVHSPQRGYQVHPEFLSRMKALATSASMNVSMRHMDGKRIRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQF6</accession>
    <name>A0A8H5GQF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQF6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="135" mass="15463" checksum="08797ECF2412602D" modified="2022-01-19" version="1">MVQDATSQRDCSRTQNDPELSLHADRRKCAAGALGLLEQPDSWKYQANRAAASSILSTVYDLPSIQSPDHPSITFMDEFIDRTTAAALPGSHLANVFFVLDYLPDYMSKWRTRAQNDFKRYTRTFHMFLKNQDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS68</accession>
    <name>A0A8H5GS68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS68"/>
    <dbReference type="OrthoDB" id="10008801at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="15918" checksum="256EC9101A3DE1BF" modified="2022-01-19" version="1">MSIRLLYSSLRSTRPFLPRASIIHRPFTTTWRTQAQDDPNINQVYSRLQNTDMFKKLLASPEALEAINEFRQVLQNQGFDLTTKPSAMQMMKLAWNSEVRAAGLKLQEAFNKAGVDLSNQNVVTEMMDIMKDLPSPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUS0</accession>
    <name>A0A8H5GUS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUS0"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="105" mass="11588" checksum="FA32A75A2B63E736" modified="2022-01-19" version="1">MGEDDETSKIVPPWVEARVRGRFQLGRQPKSTSNLTLSVSFIMLPELHLDAMQHMGALLGQGSHVHFTHLSSSSLESLKTKLANVRRENIAEASCHQAGVLDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV39</accession>
    <name>A0A8H5GV39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV39"/>
    <dbReference type="OrthoDB" id="3014077at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="420"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5371606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="715" mass="80113" checksum="0597186FE7362501" modified="2022-01-19" version="1">MDADGSDSRPVSVNVFSIVIAQLLPPAPSVPAVDYTLHYGTCPSAEVHTRCALPSWPLQTLAYLLSVTGADTTPLAEDKKTYVYSVAVTNGKKTYDTPWANECHWEVDFPIEPSDTIHAVSFKLYRTRKNLPIWRHRNLGSASFETQMIEDTEEAGEAKEMKTDMKAEKSTKDSLTLVVKAVGPETSPNANSDPSGTLGAPPNVAHKWNPPDIPENLLENAETLGGMLQLIQPFKEVFDSIAEFHPVAKGAWLVVSGAYQVLKNQHDRDGQLVDLYNLMMKTYEIATENDLYKRVGDKKLCVVIDAMVKQSKECSIFISNYGSRRYLYRILTGSEASTRIQDYKASFSDLQKAFTSSQIDLTARRVLEIESIVLSQESKSKLVELAPSTRSPGAITRCKYGTRQQSLLKITNWITQGDESVFWLNGVAGCGKSSLMGTMIQVIQQMGARSRLAAFIRFDRSAYNEARVVVRELAYQLAFFDSRLGEAIADAFQTTNRILSPDLESQLKQLVLDPLYQCREALEKDGPVTIIFDGLDECKDDDFFRELLTFFSDNVFSSFPHIRVIIASRPEAHICDAFSNADSQDLFPHILQFRLDTSSKETREDIQFYIEKELSSIKEKGFQDLCVQKNAAAELAKRAGGLFIWAVVILNFLRGYACPRLETVLETDPPVDALSALTTLYQNCSQFYCWFRGGHQERSTNSAWIHQVHILSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW71</accession>
    <name>A0A8H5GW71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="913"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1555" mass="168468" checksum="459DFA1B2BBA1F8B" modified="2022-01-19" version="1">MSRAAAGRKRMRKQAVPPSPTPSTSTDAQGVSPGSLSISFIVGKPRVKKEEKGKESDSAQQQQGLDQDASFQSNTSTTGLSTHSSGSGSGSGSGSGSLSQHGSGPRAPESFVFPTSRSRARPPPGATPNSVGVKLTLRGKKSGADQKGKGRVQDDEPGHIVDGRLRPPKLTVVTTPSSRAASHSSGSGSVISSVSPLSPSSAVVEPSTSTTPTSNLRPRSAVSAPVHIPAQLGTSTLDDAPSSSITAPTSLPTPSSISPPTSSTSSFPSSQSPRSAPAPFVFPTSRSRGHPNGPSLPVKFREARQAARARRASDTSGSSSQRTDNGDPDAANIPGPSSGLPDPHPHLNATSGTRERARPWTGTAPKWMAIPLNTLARRRKGSFGSGEDKAKRKERVNPPPVIIEDDTNGGVESVVVDISHDHDYEDVHSQRSPSFSSHPHPLYDSTQSLTLPSGSHQQDPSPSPISPHVSSSHSQVSEWTQLSNGTYTTLSPEDSYSQVGRDKNRDRDRVSLQLAARDWFWESTRAGFINGFGYEYVDEDADNDGDGGIHQGQGGPNRHSFSRRQNLHQGCSDDDDRDDGDFHGTDEEGQTALERGLARFKGMERMLKLKMEGVEGRKEYGEDYREWDEFDYNYEDVDAGRGGRQLVHAPEQSQRRVGAYPFDVYDATLLDSDQHTHNLFRKLIQHVLSTSSQSPSTPLSHNSHTTPTATSPANSSPKKPSPTAPSLPMPLSTSSSSLLSPANTVSTPSPSTFHPTPSIVLGPPLPSPSFQNFGHHPPSSVLDLGCGPHGLWAREAATAWGGFGTRVIGMDLDLDLESTSSSDDGDNNDEKGSPSADQVEKGMPEKVKLHLTTTIAENASDEIDSSLRVVGGVIQGSSGVSPISGNNVASDTGDIRADGKGEADPESPTTRSKPLEFVKGNFLTSPLPFPSASFDLVRMANLTYAIPDYKWESLLKEVCRVLTVGGRLEVVDDHVFFAYGELRHIDDNRDAGEGSGDRRTASTSPEIDDRSSYYLRHSFASSQFSNFTLTGTSADPGSSSPSSPPGAHDGSKPATSPDYEQFHQQQQLEALYQFRYRQQSWKNRQTTAQSLESLFEHLMNFKYGIHLCPSEFLEDLMERVMGCAKELGSWHFLLTRPEVENDRQEEQKVESGVGTSQHHQLKSKRQKKEKGPSPAAAIASDFRSRSMAALIASLGLPDQQVTDDSNGASSEDDDDDSNNIFKNSPGLMLWPNKLLPMSQSELEASVLKHCRTLLACSEELQQYAGELAVMTSRFEREEFRKRNKVKSRNGQDDGSDLDSDEEKELEHDVRLRAEAEVKEALEEYRSFLHERFNPPRPSLLLAPKSTLHDVPLDNDLDNDLHSIEMLQDKTEDLQAPPYPEHAFSPITLGPSVVTPTQADFSHHSRTASIDTITSVSSDARSAMWDYQSELQDHISWSSEEVNEDPPISLVSPDTPRARFLRDLDADDHAQSPNMHVHASASARFDSGYVSPDSSGPQTRAASPDSPRRVDSDREGTSRGLFGDRQEDEPVLVRTIHVYEGVKLDGSVLAMVSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWD5</accession>
    <name>A0A8H5GWD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWD5"/>
    <dbReference type="OrthoDB" id="2631350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61244" checksum="537402E4FF3B0850" modified="2022-01-19" version="1">MPCYLLALPTELVEEIISYLAEREYDDQLTTQAKNDLRSCALTCKTLFGPAIQAIWNTTDLLAVLKLLLNLEQNEAGVYVLTSELDEAAWNRFDVYSTSVKKLHENFTYMFGSLPKIQIDPSVWRRIALARPGPLLPGLIEVSRPSSSTLSTSYQTMFLVSPVLRTVILDLHYFSPSDLLAYLSSLRDVPSLESLTLYHHAEDSSEFDLSPVSLLKNLRHFQLTLPAHSSGQWTNHCITLDLGSLCYLERLEFLCFSTPNGAIDFRVPAVPSFHCQESNKTMQELDLYGLSDVRAVSRILSSFNNSPMESFSISLAGFHGLGQFRTTLSTISPQWAKTLTRLVLDAGLSRPDDQSPYSFSNLFGALYTIGCLEELHLHRLSRDIVYVSDSVISDLCNAWPRLTHLHIALNTERFFSGSSDTLPTVASLYTLGRCPALSGLEIPFYPLDIPPVDHASDDSRAQVPVPASQKLHSLFLHIPRNNFNECNLFPDALSLLASHLALAFPHVKSVKFRTFQSVNGPGLLRLKAWLDWAPVNSLLQRCHNARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWV0</accession>
    <name>A0A8H5GWV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper radical oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWV0"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="3">
        <location>
            <begin position="503"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="69087" checksum="A4C4AA9CA9E3F69E" modified="2022-01-19" version="1">MIPAGFSGGVEAASGRKKCAEQNKSNGEVFKFSQRQVPVYCFLAESLTMKFSSAFPFRPLLISVLVGSIATYAQYASGQWSLEQDGLSGVSALELAVVSETTAMIFDKVEHNPLQTNGHVAWGAELNLVTRTVRPLNPTSNTWCATGSFLSNGTMVSSGGTPVRIVPIGENGLAAVRLFEPCEDGNCDVLEDPRVRRLGSLRWYLSSARLEDGSVLLFGGSWDTGVIDNSTIINPTYEFYPPKNIHGHNGTPIYSPFLQNTLNANHFPIVITLPDGNIFIAANTQAMIFDWKTNKEVRSLPGIPNGVRISSPLSAGATLLPLTPENNYTPEVLICGGSTLDDDSVLFNSGMMSSQSPASDQCVRMALNDEGIAAGWQVEHMPEPRIMVELILLPDGRVTVVNGAQTGIAGYGFTKDQVGEADQDHPAFTPALYDPTAPLGERFTQEGLPTSDIARLYHSTSSLTPNGTILLAGSNPNLDVETHLYPTEYRLEWLSPPYMEKPRPTYSGLPRTFDYKAKITLDVDLPTGAQNVSVVIMDFGFATHGVHMQQRLVGLVSELSDDKTKLTVTGPPSATIYSPGPAFVFVLADGVPSFGSKTLIGTGAQPPLDEDALANVLSSPPLYWDKWIAVHPGEPVPAPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY94</accession>
    <name>A0A8H5GY94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY94"/>
    <dbReference type="OrthoDB" id="2898134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="185" mass="19760" checksum="6AC6937493600E4E" modified="2022-01-19" version="1">MILEHHPHPALFFHTHSSCINAGQPHTIAGSGVFFGFGSLLNCSNCVPGTPSKNCTDLSAILLALQLTPTDHPLLIHTSSDFVIKSLTYWAPGRARCGWPGTDSNLLKCITCWIASCSAPVKLIKVKADSTNQHHHNAAFLAKSACNLPLPPDGDFDDPLAVPPPDAFIPPLSSLIQPKISTNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYR9</accession>
    <name>A0A8H5GYR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYR9"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="281"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="434" mass="46970" checksum="4827740D8EA371BF" modified="2022-01-19" version="1">MSTSTTDIELAPMSQDRKVEDQRSLEFDKISTRNSATDVQVRTATAQPTLSSSIPSLLAEPENVVALPPMDGGFHAYAWLASAFWVELIVWSFPFSYGVYLNYYTTHIFPDVSTNTLAVVGSISTGLLYLSAPFVLYLVNRFPGYKRMTMVLGMLLCATGLLAAAFATKPWHLMLTQGAIYSLGGSLLYFPNMTYCFEWFSEKRGLANGVMFSGTGIGGVVVPFLTQALLDRYGHKTTLIASAIAFLSIIAPCFPYCKGRLPVAQAVNTRSLDTQALYNVVLWVFLISSLLQGFGSFIPTLYLPTFASDIQMSSATGTLAVALVNGASAPGQVFFGWLSDRNLTRSILISSLCSSLSVFLLWGLTGGLGPLLAFSCVYGFMALGWTAMWPRCISASAVDDPTQTSNLMGFFMVGEQISMSLASTSGLVHSENTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1J4</accession>
    <name>A0A8H5H1J4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="12">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIF1</name>
        <name evidence="15" type="ORF">D9758_000091</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="12"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1J4"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="143"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="12">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5375013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="652" mass="72755" checksum="B59F43AE69477C12" modified="2022-01-19" version="1">MNTGHNFYVIVGREGPRICDYSGFRLNGAGIPFGSRNEAQQWLDTFYKPKGATFSSVIAGRVSLQNSEHLTGYPNSTTYWEETEDEEMDQDDLTSCSDLSSSSSSSRSTPPPETEMAPPPRPVAAPAVVLSAEQQRVLDMTIRGENVFFTGPAGTGKSVLLREIIRALKQKYNGSIGDIAVTAPTGIAGLNIGGCTVHSFAGIGLGKEKALNLATRIALSQRLRQRWLDVRTLIIDEISMLDGRLFDKLEEIARRVREDDRPFGGIQLILSGDFCQLPPVPDESHQFKMASTFAFDAESWYRNEEFVDLLGQMRLGQLEERYKQILNGLSRPLVYSDGIEPTYLFPLRAQVEGCNRQRLRELPTPEVTYQAMDSAGVDVYGKEISRADAFKLLDRLVSPQTVTLKEGAQVMLIQNVGNGLVNGSCGKIIDFIDIHEAMTRHIQIVESKGRREPDLSKPRLSQPLQKLVPLNEAIFSNSQKWPLVQFISGTLLLCAPGEFSVEGFMGNVEARRMQVPLILSWAISIHKSQGQTLQRVKIDLGKVFEKGQAYVAISRATTMEHLEIVNFNPVIVTAHPRVIAWQHQYMSSLSQVHAAPPDIVPQTTSVPHIDVDVNMERATTTLIKVEEEDDDLWDEMDSDYARSQYFKSIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1K0</accession>
    <name>A0A8H5H1K0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1K0"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5374996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="553" mass="62546" checksum="29E2D12D30C50DE8" modified="2022-01-19" version="1">MFRPSSANSVQCFFCNQHIHNPRNPRNFRCNHCGCWNRYDDTGEISSYEPAMSDESLNARSFSKRASPSKNRLPTAYGSGPFCHTCQTNQMLLVNLLSNYLPAPSNPEYERRLEMLPEYRESLHVRYPPVCDNCMPAVEEEIRKKDSMARSQALGGWLKETKGKTTQRRVSQTPEQRLRVSKQLLIWRARGCLWCLTLCVALFGNIIAAVNESLFSPLAPLHLLPAILPLLVLVSILWTAWDPTYASVTNARIEGRDVRVQGKQTYNYLQMSAWLSRLITSSLLAVRWYRPHLDILHLSHFPLRTRVYFTGSFLLELAILTYSFVVLRVQQPPAIRLIDSKTLSSRSNTPISDQANPRSRTGTPIPPKLPEPDMFASLTLSNKPVVTSKAPVFGIPSLLSSTPPTEEDRAKDDEMDWSPTSENVNPTLPMSPGKRAPVDDGSWLRPQRFFAPENPTGLETLFEKTKLVDDVTMSDLASGQAPMRIIKAHLERWWWMYGAGLVLVVGVGLRIWLGQKLSNEQILLEHPLPGIVDELSSSGVYRHTQRPVDLNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIS8</accession>
    <name>A0A8H5LIS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIS8"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="291"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5358896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="51409" checksum="DF1367A105F2714C" modified="2022-01-19" version="1">MSSQSQKPKCKQLVLDAGPLLSLSPLRGLAESFITVPQVLAELKDKNAKEHLERLGLNFGIKIELREPEPGSLSAVIQYAKKTGDYAVLSHPDLCILALTHTLHVQAEKLKQKEKEKQEGEDLKDSQQATPETTSTEKTENITPAPTLDPSPSTQSDKAESQEEDGTEPSNPDDEDQGEDEGVEKEPLSVELHSIKNDDPTPASQPNPSSPNGPIYDDPSDDDDDGEGEWITPSNVAFHKSRALNLLPSDANGKKSQDEDVDVGCMTADFAMQNVLLQMGLNLVGTEGKRIRKVKTWVLRCHACFKICKDSSKKFCPSCGNNSLIRASVTLSSPNASDKEPVMQVHLKPNFQYRTRGTKYSIPAPKAGSAKTGSGEGLILREDQIEYVRAKKRADNKREREEAKMMKGILSSKGGSDGVAIGSWMDPDWVPEIIAAGPGGKGRSIRSGGMDGEMPVIGYGRKNPNERRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJV1</accession>
    <name>A0A8H5LJV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJV1"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="961" mass="109934" checksum="E0A52104D108CB18" modified="2022-01-19" version="1">MVRCRFPGCIERFKRQRDLTLHMNLRHFRGLADTSSQGPSLSSQSTAQQGTMEPTPDNFDIDPEDFDMCHPAPASPTHNGEDEPHASPSLPPSPHHSGAKIYHPHLFGQKLDEKGQPLVPDTPAPPIHPTQDPDNLWAPFDGEAEFRLADLLYRKVEMSQGNVDELMDIWSLFGSQCHPEDDDAASAPFHDYKDLFEDIDRIQAGDAPWKCFQTVVDESLGSSAPEWQKTSYQVWYRDPDVVISQILSNPLLIHDFDPCPYIHLDPHGKQRWSDFMSGNFAWQHASKIYDTSTDKAKLHGAMAVYVILGADKTTVSVATGHVEYHPLYISIGNITNRARRAHRNSVIPIGFLAIPKSDRKYDNDPSFRIFKKQLYHSSIAAILRSLRPAMTEPVLRQCPDGYFRRVIFELAAFIADYPEQVLLSGIVQGWCGRCTAPSDNLDAPADRRTRHLDNIWLEEHKDNGRTLWDNFGMDDGILPFTHHFPRADIHEMLCADILHQIIKGCFKDMLVEWILQYLVIEHGEKKANEIIDDIDRRIAVVPAFPGLRRFPHGRRFKQWTGDDSKALMKVFLPAVADYIPDDMMKCLSSFLDFCYLVRRSDIDEDMLQQINRSIQTFHHYRAIFLSTGVRTNFNLPRLHAMIHYPLLIIQFGAPNGLCASITESRHITAVKKPWRRSRRYNALSQMLLTNQRLDKLHALRFLLAHCGLLPPIDPPPDPFDAEHDDIGPVDSELAQAKVELAKTRDSTYPRQLQALALHIQEPTLVLLTQQFLHEQLHPGDDNGDIALPNITSKVNVYHSAVAKFYAPSDLSGVRGMMREHIRSTPSWYGHPRRDCVLVVINANREGFRGMSVARVRLFFSFRYHGVMYPCALVHWFNCYGHSRDPKTGMWVVRPGFRDPQRRQHPQLAVIHIDTLLRGVHLIPKYDSKAIPSEVKHYHSLDLFTAFYVNQYADYHANEIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK45</accession>
    <name>A0A8H5LK45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK45"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="86"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="364" mass="40850" checksum="941547C229652707" modified="2022-01-19" version="1">MALTTETDLSFLYHLLRIFLRPFRPRLAASDKHSFVGSPAGSLLLTIPSKSKCSISHQEVKGINVYEFHPISHSTASTSTKPTHRILYFAGGGFQSPPSTAHWAFCEELCLRLAGLYEITLVSYPLAPGCPAPKSLPILHKWLKATCVEGIEAKESLTLMGDSAGGNIALSLAFWWVSHLEHENEPRHHGEHASTHMLEGEIERATETEKAESTDKNRSPLKNVFVISPPTDMRNQNRATFDADKHDPILSIPLINSVAQAWAGTDTHCKWDLDRPELSPNLQDASKFMKMRQLDIRIHGVVGTWDVLAPDALVFYQKCKQHGIEGEWLKWERQMHCFPLAWKYGLSEGKRGLEWILAVLRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLG0</accession>
    <name>A0A8H5LLG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLG0"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5361464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="519" mass="58916" checksum="5A6C46ED46750913" modified="2022-01-19" version="1">MQNDKDDAKTSRSPEVLQTSQSQTTNPIISLPDHPEYDENHITIHHGVFCDGPECSQTSLGAPIKGIRYKCTVCADVDFCASCLSSSANPHDRSHAVFECVKQARFVDVRGMNQEEKTKTMDALGSDFRRLELVETGDGNAEAEGERLKLKDADGTGSEDLEESIVIRRIGPEPPKDAKGWVNQYDIGPDGSVTVESRPPGPSSREGRTQSVMHHQDADLLMKVFSRQLEKYDYFQSQDFYNFIAKGKPATRIMELFPGKGDDKLECVLRTILLHNDPASLPEYECLSYTWKETTFERANAGNWDTETDQAFRSMIDFQHPIYLPTGFITMNVGLRDALRRVRHPDKMRAIWADQICINQDDLFERKIQVSYMDKVYNRAKRVLVWVGEEDRFTAAAFSMFERLGPLVQGVPELALPTPDQLLAANPDLPIPGSFEWCSLLEFYKRPVFQRGWVIQEITLGSAVRVVCGSHETEWDNVESVTALLGSPAWLQAPWRYQQYGKSKTQSMLYHLSFHLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMF6</accession>
    <name>A0A8H5LMF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">D9758_009593</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="638"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="881"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF5362632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1488" mass="168036" checksum="3BADAFE14F059C42" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGEHTRTDVRDTAPTSPSSPPSTSTSSVALSVPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYTEESDAIELIEKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAAPFQKPSDVKKDRKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWVQSISSSDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLRLAGDMRVEVRKDNGESSSITLKNVYYNSKLPFTLISISQKADYTFTFHDHLCIIRNDKDNFIGVIHESAKLYSITTKKLSDNVATLSLYELHKQIGHMSYTNLKTLLKTDKSIITTIIDDWTETQCEDCIINNIHRLSVPKQRTSELAENFGDHFHIDIFGPLRTASIEGYKYWLTIVDDCTRWLILSPLKTKDEAYTQWVTFTTELFTQYGIKVKILQSDNDAVFTSGAFKNYLKAQGTIARYTVHDTPQQNGVAENIHQHIMNGIRVNLHTGKLPNRLWWHAGLYTMYILNRSPKTALKMQTPYFKRYGVNANLDNLHSFGTPCIVYDEARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENITETPTSQEHEPEPMDVDENETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQRDAWFDSMKAEIESLENLGTWEYVKPPADANIIGSRFVYKTKYELGKQTKLKSRLVAQGFSQQEGIDYYANDIFAPVARMSSTRFILALAASLDYETTQIDIKSAYLYGNVTDEETLYLRPPPGNLLPNLPEGYVLKLRKTLYGLKQAGRRWYEKLCNILIKLLGLKKSTYDNAVFYRYHENKLILILSCHVDDITLCTINKATAQAFVTALSGHVQVTDGGEIHWILGMEIQRDRNNHTIKLRQKHYIENILKRYNFDQLHARRTPMLPGQNLSPRPGSELQRDAAAIKHYMSLVGGLRYVADCTRPDIAYCTGQLARYLNDPGEEHYAAAKQCYLYLKGTCNYWLNLGSPTITSTYGFADSDGMSTYGNKPIMGYAFKFAESLISWSSKRGTLVTLSVTEAELCALAHASQEAIYLKGFIEEILNAEQEPVLINSDSASTLAIIRAPEEQHTQRTKHFNIRKNFLTDRIHQRYIRVKHVSTNDQLADILTKALSADKIKRFSRLLGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LP98</accession>
    <name>A0A8H5LP98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_008186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LP98"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF361">
        <property type="entry name" value="TRANSCRIPTION FACTOR SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5364925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="236" mass="26194" checksum="B841B165652CEC49" modified="2022-01-19" version="1">MEDSMPSTSDFVKKLYKMLEDQSFQHVVAWGPQGDCFVVKDMNEFTKSILPRMFKHSNFASFVRQLNKYDFHKVKNTDDNTFGEHSWTFRHPDFHADRRDALENIKRKVPNSRKGQQQMPPQAASTTRPLGQPMAGPSMGMPMGGQSMQGMGAPSMGNMNGSPGPGAGGWYSGSPGASDSASYIQHLQSQVTQLTATQEELSSHIRSLERNMGNLERGLGGLERNYHEVSGFCLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR89</accession>
    <name>A0A8H5LR89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR89"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5366456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="379" mass="41843" checksum="79F4675BB3143C10" modified="2022-01-19" version="1">MDDIGTFPDEIGRAHQGPSHVHAHGNFLDVLDPVTVHGLQSVAYNRTNLMQSNPSFGLSIPYNPLLRFNEVRSNNLPKIDIRTILLLLLSSPNIRMAMKRRSVMYAGLLPSSPKAAKSGSAKKPAAAPFASKASKTKKNPLFEANPRNFGIGGDIQPQTDLTRFVKWPEYVRLQRQKVILNQRLKVPPSIAQFSHTLDKNTATQLFKLLNKYRPETKTEKKERLTATAAAATEGNGNTDTKKPLFVKYGLNHIVALIEAKKASLIVIAHDVHPIELVVYLPALCRKMGVPYVIIKGKARLGAVVHKKTAAVVALEEVKSEDQRELATLVSAAKANFTDKYDEHRRQWGGGIRGNKSTQMFRKRAKAAGQNPAAANITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT37</accession>
    <name>A0A8H5LT37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT37"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="41977" checksum="37DB48CB216179CD" modified="2022-01-19" version="1">MDLCTYCTEVSTIHTELIRPRSARCGGGFVVPYPLNCAFTIQQLCLPSSLISILVTMISLERSFLLAAGFETLVYGRSSQRAEMILKLNLTHPGLFFCIFGATLILQFTSYNNFRSGDRHGHTMTTISTLMFVIATVHLATNWYRMLSGFVDHNVAQGGVVSYLNRLDDWSRIVVDTLYPSQENLGSAVARDWKVIVPPLILLVGNIVAEISILFLYIRADTATVIFDHGLQKWITSFFIINVCINIITTSMMAFKIWSTHQYWSRYNVENGSFLMSILRVFLESAALQLVTQIVLLILYAIKDNAQEILLQSAVPIVGITFNVIAIRIRIHLISSTKPTTVSQSNQSSDTIGSVRLRPLVVHVSTATSVVEGSGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTU4</accession>
    <name>A0A8H5LTU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_002740</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTU4"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="66"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="403"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5369322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="598" mass="64040" checksum="803C548D22A43351" modified="2022-01-19" version="1">MLRRPRSSKPFWSSCSPRSFSSSSSHHEKPVLNRYSRNITQPKSQGASQAMLYATDGIKTDEDFSRPMVGIASVWYEGNPCNKHLLGLGRVIKESVEEAGVIGYHFGTVGVSDGISMGTSGMTYSLQSRDLIADSVETAAGGHWLDGMVVVPGCDKNMPGVLMALGRLNRPGIMVYGGTIRPGSCEGAPQLDIVSAFQSYGKYLQDGQSPEAERERYNTIRHACPGPGACGGMYTANTMASAAEVLGMTLPGSSSNPAESKDKMEECAVVGPALYNLLEKNILPRDIMTRTAFENAMVLTMIMGGSTNAVLHLIAVAHSVGINLTIDDFQAVSDRTPFLADIKPSGKYVMEDVYKIGGTPKILAFLLKNKLIDGNTMTVTGLTLGENLDRWTHKYGELDSRQDVIRPLDNPIKSTGHIRILKGNLAPGGAVAKITGKEGLGFTGKARVFDTEDAFVRAVETGSIKKGEKTVVILRYLGPKGGPGMPEMLKPTSLIMGAGLGHDVACLTDGRFSGGSHGFCIGHVVPEAQVGGPIALVRDGDIISVDAVQNTIELLVSPEEMEERRKVWKAPPLKVTQGTLYKYMKNVTDASHGCITDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUG7</accession>
    <name>A0A8H5LUG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUG7"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000069">
        <property type="entry name" value="Related to syntaxin 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="307"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="397" mass="44470" checksum="3E1BC2F843DDE5AC" modified="2022-01-19" version="1">MVCTSRTREFLDLVNAKQSSSQAPRKQNILRQIHQDRERDEQVQFGKQFVKDAYTILDGTKKMSRMLGSIRRAYLNVDARSGPSRLQDTTPIDINELESWSNIRQLSNEQRDQIDLHARLFLSKCADRVKEMEALEKKRVELLASKKNPLARLLPARLMTDKSSASADYVSAHHSGVTWYLNRRLAEASETQKEMQEERIKRQTERSRTLGSGATVEAFRLGPGGSSGTPEQSNQDSSSSSSWISSTPSNLIAAAIGAPSPKPTQTSHASTSYSLPEPSIPSDDEDDDLELTSSQILQFETENANILRSAQEDLEAIQQAESRLMDISALQMELVSHLTQQAELTDQLYEDAVATTSMVEKGNKELRDAGRRSKDSRLFILAFLIGASLSLLFLHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUL1</accession>
    <name>A0A8H5LUL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUL1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="481" mass="54490" checksum="262DC4A0BBBF443E" modified="2022-01-19" version="1">MHGSPAVPLATSLGKTMAQITAQFAPFPARQLRDRCHRLLLTAKETEAKNISGGLRDSLEAINNCLLDVKIRMHGWTTLKKFDAFVRQSEIKHDIENCHAAISDCLTKFSIVSQVEINQWQEEFATNAKLDHQEIVEYLSEIQNANEMLQLTMNDQTGLLTKMMEMMQLTMSENKHTADRTHNGLSSNLYQLQLQSNEILPDLHLNSGEVTRIGQFPVSGTAAMDIYEGLYLQREKVAIKVVRAVNSNEHSLRRFMREVKVWAEIWKVDRGRYVLPFYGFCQNDGPFPYMVSPWQQNGSALSYVKKFDLSVNYPLMVKGIALGIKVLHEMEPPVVHGDIKAANIVIDARGNPLLADFGLAQIVEDITGIPFTQSRGVADSYRWFAPEVCVGEGRLSIMSDIYAYAMTVLELFTHQQPYGNIKHTTEVVIRSSQGQFPERPPDPRVVQRGLDDNLWPLLTKCWKLQASNRPKIHEVIEQLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXG6</accession>
    <name>A0A8H5LXG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXG6"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="45198" checksum="A677F5E6AC819D38" modified="2022-01-19" version="1">MSMDDIRKSVGDNLLRSVLSPSNSTSTASRKSDIRNAEQRITPWEEDADVSKCRICLASFHPITNRKHHCRLCGRIICSLPATPGYVVVPGKEGKGKAVPCSSLFVVEGPRGQRRIEEVGEGVDYGVRRRRTVSMNSGGGSSVKGNGTRVEEEEEEEKFLKGVRICRDCRPVLLRQQYLREMSIIPMFARLYDVRLHIPREGTRRLSPQFQELILSLNKDLGTISPQSIPTHEANVARKRLLDLFAQYDALSKRIRSLPCKPGSSQDRIQLAVMTRANVFLQQHMFPLQAIPKQSSNSKTDSEKERTGKGGKGKEGGAGGEGEDEGTIINGTKLDPPSELSMKLQPLLEQELLLESFVEEATAHRKFEDAKTLRRNLGEIRAEIEKIVRESEVELVGKRGGTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY80</accession>
    <name>A0A8H5LY80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY80"/>
    <dbReference type="OrthoDB" id="192148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="39576" checksum="38293E5B30F7877A" modified="2022-01-19" version="1">MLQNPTKEKRKTSSSSSFKVSKRFEDAIDATSDMTSNFLGISIVVFDALKDASIAAPFPYAFIAASLALQIVEAVQGAKDNKITLQRLARDSCELMYMVMTTLKELVQAECSDEVVKDASLNNHLEKLKQTLEEILQFAVKRSNRSRMKRMASSKGDVGRIQEYRERLKQALDIFGLQSTITVRSSLVRLAARQETFHEILNERIPSKDITDSLPFESSYPERSELSGMITNDLVPSPTATIIPESSPHELVLDNGEELCVSPVDETATGAESSTSRSPEKDASTAETAQAAVFCFTGSGINIAGVTFNNYSTSHSSVNNVNNSSLRNCGNTYYWGSGPCSDSQGLPSMGGNAGRLFEVVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ24</accession>
    <name>A0A8H5LZ24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ24"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5375275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62322" checksum="DF76C0480EE887AE" modified="2022-01-19" version="1">MDQQSPFSHLFNTNYAAASNEDISVIQDLLSAPLEKLESLNSEIIRLENALSGLKAERDHLQSYVDQHRNLLSPFRRLPPEIISEIFIRCLPEDSRPTHSLSETPLLLGTICRNWREVALSTPYLWSCINVVLPTSGSMHLLCASIDRRRDGVEAWLSRAGELPLSFSIHADSQLSFRQIPSSSSQDMDERKAAFSEHTQELIGCFTRRIARWQKVILQVSPFCMQIFEASMLASAGSDWSFDEHHCLEGFSIHSIRRIPGQPVMRALPKFLAAPSLRQVAMTNVPFNLQELALMTPNLLLLNLRRGHSSRSPSPQDVFSLLSRFRNLRECSTAICFTSQATSFDSLETLCLPSLQSMSLIIIMDSAAVDVDTFFRQLSLPSLHSLTIKVFTRGAMEHAPFVDLLASSGSHIRELHLSLELPVEGLLECLAHLPLLVKLSVHNGKLHGDPGASFVRRLTPCTQQPEPLCPNLQQLSLSGIDVKDEELLKLAHSRRRSSFEVSQLEFFHVTHLGYQELIDLERRMEELREMGMKIEIKHVYQGIRPIFDADVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ84</accession>
    <name>A0A8H5LZ84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ84"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 7">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="6">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="18622" checksum="011CD7301677B9E0" modified="2022-01-19" version="1">MTSLSPLFFSTFEVGKQAFYRSALSYAIVNLKPIVPGHVLVIPTRVVPRLADLNDSELASLMGSVQRVGKVVERAYGADALTIACQDGKAAGQSVGHVHFHILPRISAGDRFSNNDEVYPALERSAVSLASDMKGDVQPLKVDADENRTPRSKEEMEEEASWLRGFFQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZJ7</accession>
    <name>A0A8H5LZJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZJ7"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5375159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="268" mass="30619" checksum="245A02160385B2A3" modified="2022-01-19" version="1">MRSSRRQNLIFRSTCSSRYVCQRSWTRHDDGGGKGGSTWVQVYTGPALCLNLLIYQDVFKMIPTPDLSHLTRADYEHVYEPAEDTFLILDALEEHADELKKMAPLTCLEVRDAYLVSSVKYWVLRRYIYVPTSTRTPAEVPLEQIHLDVVHTSLAHPLHTRLKHSIDIILFNPPYVPTVAEELLDAQDLKGIEGSWAGGQDGMQITNKLLDEVDVLLSPHGRMYLVALKENNIPEIQLRMKNLYNLQSTVSFVVIAYAVRFNESVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AZK3</accession>
    <name>A0A8H5AZK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_019026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000530">
        <property type="protein sequence ID" value="KAF5313531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AZK3"/>
    <dbReference type="OrthoDB" id="3264316at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5313531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39540" checksum="531E50D720863D05" modified="2022-01-19" version="1">MLILNNWKLDPALALPKEKQKTCWLQLRAQNQPNNINDQHIATSAAASGSKLSKHRPAPCAKQLSTSTSFISSPVVDTDLIQSIISEIADLSSRLPDSVPIGQPDRKIATSLNEEAESPWQGFNLFFDHVFGADMVDSVTGCFKFISWGAHSMDFVNQYLQTVLQQHLNELLLKLVHMWLIQIQDELGFLVGTLRRDQNREISAIDEWVFQHEEFQDLGLSKEDWKKLKQLEEILEIFTVVTNIMSQADTLTLPYVLTMYCNMEQKLTAMKKNPELASFSDAIDAGIISWLSATVCHPSFCLNWFGKCSLMEYQQAKILFEHVYESYATAAPADPSPRKPQLLKISYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BAV9</accession>
    <name>A0A8H5BAV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_018449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000430">
        <property type="protein sequence ID" value="KAF5319854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BAV9"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="622"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="627"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5319854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="726" mass="78885" checksum="28E3EE4E43742EA2" modified="2022-01-19" version="1">MQRLSFRALLLANEQRSAYGLRYHDYARYRKHCANRTHRLRSSLRKTHKKNEPTQDGHLQLLLFESERAWSYAQDLLTLSLNQPPDASPSASSLRHHATGRFRRAIHWATQLLSTCQSLYTSSRLSALSLLEATIYTLILNGRFLRFRDDFDSALVQLSVARSLLDELADPLNAPTSRDQALASVFADEIGAEIRYCAHELGMERAWDVDSIVKDVGKKERAKLVDGVEEILKKYKEQVTESKGGHHQKEQRILEPLMWEGEPIPVRNPELVDVLLKVQQAEKKLDGGEAHKTGSKKSIAAYDAILSALSDAEDVARRLAESQGSGGSGIPASNVGGAGPGASGGGTTRDVQFVHTYIVYQLLSRRIQRDLLLGSALISQAQVESESRSASTKSKTPSTGPGAATSQSKPTSGLKDANSKDVHPRILTATLKLLDTILQSLNQMRTLSIVDDNPDLAEAVDARVSWTRGRRCLNLAHCYASPPIRKYAEALTLIQHANLHLRETTSHLSLASQASSSGQGDGDDNADLTDLISSPPPNSGTIPFYALSQLEVRLLERELGRVGLRVKRDWFAWNGGVGQVTAADGSEESSKKQKTNKKKPPLFFNIALNYVELDMERLEDRGGGKATMGAGTTANTTKSSANTNTNTKTNTKPVEQTTTTMNTNPMKKSAALDHEDDMQSRSGTPEPSSASALGSGSSNQGAAATLRTGGAGGGLSSLLGGWWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BS37</accession>
    <name>A0A8H5BS37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000359">
        <property type="protein sequence ID" value="KAF5328534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BS37"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S53" evidence="2">
        <location>
            <begin position="66"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5328534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="43683" checksum="2AD1C903B776A90A" modified="2022-01-19" version="1" fragment="single">YSVPLDLVEHISLVHPIVTFGIDSGSNLNLDVTAHGRSLRAQRSTRDNGTEPEVNSGVIDESCATKVTPACLQALYRISNTPATQSSNRIGVPGLIQQWAQKADLNAFLERYRPDMDPNTTFSLETLTGGEDPQGPDKAGSEANLDIQYTVGLATGVPTTFISAGCALCDGAHGFLDVVEFISNQTNPPQVISMSYGFTEEEISPDLAKRICDAYMALTARGVSLIFGSGDAGVSGAIPGNETTCTSFVPTFPGGCPYITSVGGTQGISPEVATNFSSGGFSNVFSQPSFQQPFVSAYLESTGVEDTYAGRFNASGRGFPDVSTQANHIQIVVGGNFTEIWGTSASGPIFASMIALPPLGYLNPFLYANPQIFNDITSGNNPGCNTEGFNATKGWDPITGLGTPNFEALLLAAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BSC0</accession>
    <name>A0A8H5BSC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transitional endoplasmic reticulum ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_017024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000362">
        <property type="protein sequence ID" value="KAF5328470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BSC0"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="8">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="7">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="221"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="497"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5328470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="89509" checksum="19B2BAADA68D040E" modified="2022-01-19" version="1">MADPSGAPPQPGPNDMSTAILRPKKSPNRLIVDEATSDDNSVASLNPATMETLQLFRGDTIIIRGKKRRDTVLICLSSDDVEEGRIQMNKVARNNLRVKLGDLVNVHACHDIKYGKRVHILPFDDSIEGLSGNIFDVYLKPYFLEAYRPVRKGDTFLVRGGMRTVEFKVIETDPAEFCIVAQDTVIHTEGDPVKREDEESNLNDVGYDDIGVAVNKWLKSPPRGILMFGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTLDQRRSRKACRVSVAHSYGWFEGSFQRRRHGCYQNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILRIHTKNMKLADDVDLEQIAADTHGYVGSDVASLCSEAAMQQIREKMDLIDLDEDTIDAEVLDALGVTMDNFRFALGTSNPSALRETVVEVSYRLLGRHWWSREGQTGVAGDSAVPSRPPEKFLKYGMSPSKGVLFYGPPGTGKTMLAKAIAHECNANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVMFFDELDSIAKARGGSSGDAGGAGDRVLNQILTEMDGMNAKKNVFIIGATNRPDQIDSALLRPGRLDQLIYIPLPDEVSRLSILKANLKKSPVSPEVDLDFLAKSTHGFSGADLTEICQRAAKLAIRESIDADIRRAREKAEKEGDDAKMEEDEEEDPVPQITRDHFEEAMKFARRSVSDQDIRRYEMFAQNLQQSRGFGNNFKFPEGAGAPGAPAATGTTTSNVGFTNDEGMTICMLEKKNCFVFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTP9</accession>
    <name>A0A8H5BTP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000345">
        <property type="protein sequence ID" value="KAF5329133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTP9"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="393" mass="42912" checksum="776A387FE4F14FCD" modified="2022-01-19" version="1">MPTPKGHHTGSTYSNPWAPGFSLRKCAGAILKGPLTRGTPFELAIEPAKTVQCHFGLYESEDARKAICTTWLGHAGFLVRICGSVTVLFDPIFSERASPSSWVGPEDGYLRLAKSLTYRIFSMSSSRITSTYDHLDTQALRDVKERSPNVHFLVPEGMRALIVEELALGEDRVKELDWWDAVSYPGDDYKIEFVCTPAQHNSGRGILDQNHTLWASWVVRCFPLGSGSPTASVYHAGDTGYTTSSGPCPVFAEIGSRYGPFDFAMVPIWRGASLSVLGRMGLRLTEDATHTLLSTLHASPKDAVSLARDVRARHTLGMHFGTFCGSEDESVQPLVELAEALMDGSEEVIHEGQIAAKGSKSGQIELRESWKKDGGFGIIDVGQTVIVPLHTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXM3</accession>
    <name>A0A8H5BXM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXM3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034455186" evidence="2">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5331445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="35470" checksum="5EDC37AD36855F00" modified="2022-01-19" version="1">MAGKTMSTTIFLGIAITANGLSVDLPRLTPSVSATLTWHRENGDPSVNWHFKESDVAGGISIFPDLLNPGDASGQVPIVVTDSSPFTTFGPFSVETPQAAPPLTATSTTPALPALSSSTSNSIEPQSPHQATPTGTNPSEASITANTSSSSQKTSDWKFSSSSEAFKSSGEESTISRKYKTINISIDRNLHQNKYKTPSIFRARNNPSLRPRQWTSNVPHAIGHPDVPTSTSSQERDHPVDRDNRRSDFRSISPFILTESSTTGSHVKGRNVNLSEVGSDGNESASSGSSDPTRQEHGWRAIVGRGTGFGIHRNANRNNSKAADTLPPPYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4U8</accession>
    <name>A0A8H5C4U8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_014775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4U8"/>
    <dbReference type="OrthoDB" id="621413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5335237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="42365" checksum="14070B96E5020E73" modified="2022-01-19" version="1">MLANPGDIYRMLSQYEDAKVMLEQAKEQFEGIGDRLGAAQCLQRLGDICSMLSQYEDAKVMLEQAKEQFEGIGDRLGAAQCLQSLGDICGALSQYEDAKVMLEQAKEQFEGVGDRLGAAQCLRILGDICRMLSQYEDAKVMLEQAKEQFEGIGHRLGAARCLQSLGDICRMLSQYEDAKVMLEQAKEQFEGVGDRLGAAQCLQILGDIYRMLSQYEDAKVMLEQAKEQFEGIGDRLGAAQCLQRLGDICSMLSQYEDAKVMLEQAKEQFEGIGDRLGAAQCLQSLGNICRMLNQYEDAKVMLEQAKEQFEGVGSRLGAAQCLQSLGDICRVLSQYEDAKVMLEQAKEQFEGVGDRLGAAQCLQRLGDICGMLSQYEDAKVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C597</accession>
    <name>A0A8H5C597_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C597"/>
    <dbReference type="OrthoDB" id="2977752at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5335238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46856" checksum="0061A0CA701AA9F2" modified="2022-01-19" version="1">MSTAPSSASIYETSPPIPSQELLDRNAKSAESHKPRSLSDIVNDNRDSKSQGIAIITCMDSRIHPHKQLGLADHDAIIIRNAGGRVTELIESILTTQYFGTRHFMLIKHTDCGGFYVTGPKFKEHFKAHAKNPDTVNSLPGNSASDQRGFGNATIEQVVLSEVEYLRNSPLIFEETTISGWVFDDNTGKLLVHGQIKEQQLTQLLNLQNLRLNLLRLQYYTKLHLKLTAMSTTLVSGASTYETSPPIPSQELLDRNAKSAESHKIRVGLHDNWEKFPRNAIITCMDSRVHPHKQLGLADHDTTIIRNASGRVTELIDTILTTQYFGTRHFMLIKHTDCGGFYATGPKFKEHFKAHAKNPDALDSLSGYSANDIRGFGDATIEQVVLSDVEYLRNSPLIFEETTISGWVFDDNTGKIRQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C788</accession>
    <name>A0A8H5C788_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_016903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000243">
        <property type="protein sequence ID" value="KAF5335423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C788"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5335423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="193" mass="21222" checksum="6E5709DF41AFF2D0" modified="2022-01-19" version="1">MFKMKEDRWKHHFDQRDQFQPAPDDFLKLYASPLDYALSARLTLVQPSLDLASSTPSTSSHTAQPTENLPSNSASTALSPLLSYDGKQGVHQNVTPENLVVFTAAYNTLWKCLATFKVPNWPACSEGACICAWVGYLMAATNPTRRYSPTNAASPEHPAMHLSLQPSLLCGVKDPWATSTPRMGILAPTEMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7Q2</accession>
    <name>A0A8H5C7Q2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7Q2"/>
    <dbReference type="OrthoDB" id="2883937at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56941" checksum="0ED867B44B81CFE7" modified="2022-01-19" version="1">MSLKTQAANLRRSIQHSRTLTRSYISRLPPELLLEIFESCLPPFPLSHSDRVSFHPLHSDNDIYTGVDTFVAVKLSHVSRHWRSLALSNPKLWSRIIILAKSTDKLLHPWDMTPSRLITALTHFLKCSREYPLQILFQSIWSNAESHHIILRPLKLLLDQSHRWDRVHFSLFAAQIARLVFPTHFPLLRSFTLYNEVGFWATVLPVFSAPRLESLGLKRLDLAETDFRRGYPHLVDLCMAYYEVSECISALATASPSMSMSFEKMYLEHDRPNLTPIISLASELRVESNHDFQPVEAVESLLGRISSMPHLHALAFTKSPAQLRLFPTTAFKSFLSRRQATDSAITQLHFGQWMVDGNLGLIEVLTLLPSLTHLTLDECPPSRGIIRQVDAQRLISDQLLRALELPTLESESDMEITCLLPRLTHLSLSFCNVEGGCNFQILLPMVQSRRSPPRITATRVARLHQLEITTAPDLLAAEDREILLALREGEFDVQCRVISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C841</accession>
    <name>A0A8H5C841_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000235">
        <property type="protein sequence ID" value="KAF5335873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C841"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17058" checksum="8B6E7BC333E54312" modified="2022-01-19" version="1">MAEESGMAHLVRRLEFKLSTATDKTSSVHAYFYLAPVPVFVSSLSAACNFSQFAIYTCPGFSVVSLIKIELAWLRQLCIGKGCSEVGSCRRKGSAAPSRVGVKCFTSETNGIHPFPSYAFSAANDMLGCGQDGVEMMIETAIYGHIQDGFPYLDFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9C3</accession>
    <name>A0A8H5C9C3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9C3"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="29464" checksum="E99A7EBF3D17A261" modified="2022-01-19" version="1">MHLWTVLSSSSFNVKKPLHRSQQHWHTLQAFYTSLHALSSHGQLSPDAQSLSYSRSQSMTLMYGNSPQIPILSPHSINALPHHTCSQADKHMSEKRYTKDQACAVMGLASNLLQGARLHHECLESVFSHQIWNQSSPVKLCTNISPSLESIDWEIVQAMHQGVTTVKLNTSSLSSDSSPIFSFIVVLNLAAETDANLTAKHPNYAILAAPGSITISNHKETKKLFPTVIKDNMINLKNGKAASMISKETYETAIANKEVLDSAIIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB37</accession>
    <name>A0A8H5CB37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_012239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB37"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5338451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60636" checksum="D8656312ED41474A" modified="2022-01-19" version="1">MLSLFSLFLFALLLVSTRLLFWIVNLLVIAPLRDPLRRVAGPDAPFFHGHLTHIGDPDLSCVAHEEWCKLYGKTFRIQGLGKFDYRLMTFDFRAISHVLNSPIYEKPWQTRSLLSTVMGRGIFAMEGAEHHLQRKIISPAFTSQAVTALTPFFFQKAEELRDKLDVLLNKESGPIDISHWTSRATFDAFGLACLNYNFNALDSETEEVYLAYRRMFHLVDKKTVLRILFPSLDKLWPDAVAREIQESRNVIYRAGQVLIANKKASVCAEKCDLFSVHDKDLLSLLIKSNLSNDPSKRLSDSDLLDQITSFLFAGSDSTAVALGWCLLFLAQHPDIQSQLREELVQSPPSASTIEAFADDIPSYDAFSGSLPLLDAVVKETLRFCPPVHGTIRVATADDVIPTSSPVTLCDGTVAEPGQSIHIRKGSFVNIPIEGLNYSREIWGDDALEFRPQRWFNLPPNARPPAFPGLASVMTFGYGPHSCPGFKFTLTEMKTFIATLLPHFEFSVVEGQKIGKYNGVLTRPFVKGSLSQGLQLPLLVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBC3</accession>
    <name>A0A8H5CBC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000194">
        <property type="protein sequence ID" value="KAF5338571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBC3"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="103" mass="11716" checksum="17DCC72D7D518A27" modified="2022-01-19" version="1">MLVISAVQADEAGAVFPWEGDWDNFTHALKVQFGVANEQQLAKSKLEALKQGDKTVTEFSQIFKMWAEKTGFSDQDLQYKFRKHLHKDLLFPLANVELGEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBF5</accession>
    <name>A0A8H5CBF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBF5"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="147" mass="16574" checksum="CF877A36A815B3FF" modified="2022-01-19" version="1">METPNVFDRPEANIMNLVRGSTNIPVPRIHRLISSEEVDYRHCLFVMDCIKGKLLSRVWNQLSLWKKLLGGDHSAPLCAGIATNKTTKRILTIDSNRLDEIRRTNPNNDSIVSLHTIAYAEVTVDPEGILLSDLWEALHDEAEDSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD17</accession>
    <name>A0A8H5CD17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000185">
        <property type="protein sequence ID" value="KAF5339486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD17"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034017113" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5339486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="277" mass="30367" checksum="415DC47C221D0718" modified="2022-01-19" version="1">MKLASLLSFLTLACVVPATVAQKSHNHQADQVNWSAHEWQAPTATDSRGPCPGLNTLANHGFLPRNGKNITVDMVMDAIHDGFNFDKGTLILRVAAKLGLLTTDEIDNYMLEDLALHGTLEHDASLSRSDIFPDGSGDNLHFNETVFSTLANSNPGSDVYNITSAAATLDQRLALDMIEHPDLTNTIKEFFVRAIESSFYLSAMGDPIKGVAKKELVQIFFREERLPIAEGWVRSPVLITNEILGNLTGRIQELSNWTSGPGCPWIRLQPEGDVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CES1</accession>
    <name>A0A8H5CES1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CES1"/>
    <dbReference type="OrthoDB" id="3250441at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="54794" checksum="AA9BEB2D00D2062C" modified="2022-01-19" version="1">MASTIYLKGYALCNPPLSQAHFLLEADSSENLLQLNKKVQAKTKLSRSEFTFYKALGINIWPKENLPERVNGWLDHNLEEALDPMYAGQIQTIWTDNDMEYDNMLHFIAVDENALADLQLIHALSDPALYARVLDIQEHASTLNGFEQFPPPSQGAASPQDVHTRANGIRAGRPATYHGPSNALFDRHLAILSDKLRNLEIVHPTTDMLDFANRLVDTCAKFYETENAREQPVFQLLNEHFPNARHQQSITNNRAKPEAFWFLALIWELKNEQGNGGNVVVRAAIDYAKILADNNLSGHIRDRSNCPCVLLTLAGTDLNISTAISTDAVYIDTLYLQHLRGSFDRETLVLSVARAMQALKETFKKLSNFYAAMEANPAQSPRDGSYLFPNPVHAGRHDENLLETLGLRFLHKLSRNEEMFGNSRKQREENMSYTVYVALSSGNCESVPAGQVVVKFAQRYNLDAHELLAGADLAPKLYYHCPVLGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFN9</accession>
    <name>A0A8H5CFN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000183">
        <property type="protein sequence ID" value="KAF5339652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFN9"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034218555" description="Cupredoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5339652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="40142" checksum="37834C74452D4514" modified="2022-01-19" version="1">MRFSTTRTLPIAALASSLATTALATNFDVAVGANGNLLFYPEYVIAQPGDTVNFVFHPKNHTVTQSTFDSPCSPADGGINSGFMPVAPDLEGGPLPNWSVTVNDSTTPIWIYCQQTQPKPHCGQGMVFAINPPPADSDKSFEAFKAKAVSTSGDSIVAPVPSAPPPQTWAPATATVTSSGSTWVTTYTSYEGTPQPTYPPQPVTHKIIVGDSSQLIYNPMNISASLGDTVVFEFHPKNHTVTQSTFNSPCQPKEGGFDSGFMPVSPNTTSGFPSFQITINDTAPIWGYCQQTQPASHCGAGMVFAINAVETGPNNFSAFQALAIAQNGPGSSNGSDASGNGNGTSGTSGTSGDGNGNSDGSTNGGVSIALSLRKGSAVLGAVVIVFAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJD2</accession>
    <name>A0A8H5CJD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJD2"/>
    <dbReference type="OrthoDB" id="3271097at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36571" checksum="76F34D2C6ABB2459" modified="2022-01-19" version="1">MVSNRYRTGKFYMPFLPATISIMPPQRTETSIRAANDPSSSPAVAPKPKKKRNTNTSDGAGALNQDLQAAAPRCKPQKKTSTKTTTSENGKQKETVEPATKVAGTTSSTRQPMENSAQANTTPTVSDIDENSAEYWKRKFLETEARRVQATPADQSAGTPTAAVTPPAIPTLGQKKHTIEVILKPRGEAGNAKTGYNLQKAIKLEDDVEYNAFLAFVRNNAPRAGIDLNKNFSKQDKKALYDLGCLTAKDLPYFTKRRFPGYWPVDQALKQFLKNRNKRINKVKRANQRKQVSGDEDDEEESGASGINEDEQDEENDEEASAEEPGSGEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJW5</accession>
    <name>A0A8H5CJW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011128</name>
        <name evidence="4" type="ORF">D9758_017462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000370">
        <property type="protein sequence ID" value="KAF5328036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJW5"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5328036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="34614" checksum="C9F3BD422DF6B08F" modified="2022-01-19" version="1">MSTLPTVLVFGGSGLTGASIVAALLEREEFEVKVPVRPSSINKPSTIELQKKGATILPFDIASSSSDVLQEFVSGADTIICAIVFTQLSLQYKLIDAAKSAGVERFVPCDFGTPGRRGVRKLHDQKLDVREYVKASGIGYTFIDVGFWYQLHLMYTDVKKAYVPWLYEASRYVYNGGVVKTAYTDLADIGKFVARIVTDPRTLNQYVFAWGEEITQQDLLKYAQKYGNPNVEIFPKSTTDLESLIAEAKEKKLGTLAYWDYHYSMWVLGENTVEMAKLPELGGALDTRELYPDMEVRPLEDYAIEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK49</accession>
    <name>A0A8H5CK49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK49"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="346"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="507" mass="56562" checksum="F8819D8CF923BDC9" modified="2022-01-19" version="1">MGQSNSRYKHPFPFNPQPAGYYGAPYPNPMPQYGQYGMVQPVQPMNQHVVVPYTYMPQPQPYNSHSTRRRKKKRRDGSSSSMRRRNTGPTYRAGSARFDDSTNQGSNHIRRAQTPFHHSAHLEEEEEEQEEMEEDGFDAPEEFGGSRRHRSTHHVSQSVPGPSLPPPPEMKMLSPHPPNPLPLPPRDIFESAEYKAVMRGPVGTSALLATMYPPKDEVRDVEPQRSKTGFFGKRSSKGGLFRSLTGTKKKKEESPRPDITVGNGIRLLPIPVGVSDYHKLSTPTASGATTAGAEPVFPHPPPGVTNPAQAPAAPFLMAGAGPNHLAQPPAPTTPTPSESTEPLYFNQTHPDYGGFLPHSHHRIEYGGHIYKSATHLHEALKYPEHPHIAESIRACTTLSDIFHIATSNADRARPDWPGKFVEVMEWVMMKKFEQHPNLRALLLLTGNRPLVYSEEKDPFWGDGVGMDVDGVRRTVAGMQEGANELGQMLMRIRERIRTQSPDPFQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLD3</accession>
    <name>A0A8H5CLD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pheromone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014952</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000152">
        <property type="protein sequence ID" value="KAF5342938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLD3"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5342938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49571" checksum="C0D91DCD7AF4D5A1" modified="2022-01-19" version="1">MYDPTYPAFPILAFIGFILVLIPLPWHIQAWNSGTSLFMIWTALGCLNFFINAIVWRNDAIDRAPVWCDISVALNTALNVAIPCASLCINRRLYNIATCKTASVTRADKRRQVIIDLAIGVGLPVLQVPLHYIVQGHRYDLIEQIGCWPTTFNTPPAYPLSFLWVPVISLISMTYGVLTLRAFMKRRQQFSQFLSRNGGMNVSRYFRLMCLAMVEIFITAPITAYGLSLNIRKTQIQPWISWENTHFDFNVIDTLPAILWRYNRQAVITMELARWPLIVGPFIFFAFFGFAEEARKHYKLAFNYIRKRLGFALPPKVSAFTSSFKKKDEFVPLPMAHTPNLPRSLILPHITVSTSGSRDSITSVAATSLHKSDLKFDDSPSPAMPSPPPLYKPRESFPSSPTSSSSCSATYIADDEPRPHSGQVFHDNVSLSESKLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNI3</accession>
    <name>A0A8H5CNI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_010425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000792">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="108"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="1254"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="588"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="863"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
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        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
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        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
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        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
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        <location>
            <begin position="881"/>
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        </location>
    </feature>
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        <location>
            <begin position="924"/>
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        <location>
            <begin position="1095"/>
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            <begin position="1140"/>
            <end position="1157"/>
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        <location>
            <begin position="1191"/>
            <end position="1226"/>
        </location>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5345019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1303" mass="140640" checksum="72F2CCBB4F924F80" modified="2022-01-19" version="1">MTTAYPTSLTKQLNQVPEEGAVTPSHGGMVMGHEYDMPIVQPRASAAPRPRPLSMPPQSYNVTAASTTGSSSDAKETRHDDRERDRDRHRHGGTTSGRSRSNRILGNYTLSKTLGAGSMGKVKLATHNVSGEQLAVKILPRANPSAPPPSGATPDSVARQASKDASKEIRTLREAALSMLLHHPYICGMREMIVHQHHYYMVFEYVDGGQMLDYIISHGKLRERTARKFARQIGSALDYCHRNNVVHRDLKIENILISQTGNIKIIDFGLSNLYDPVAHLGTFCGSLYFAAPELLNAKVYTGPEVDVWSFGVVLYVLVCGKVPFDDQSMPALHAKIKRGLVEYPVWLSPECKHLLSRMLVTNPAARATLTEVLSHPWMIRGSSGPPENHLLHREPLRADELDRGVLQILKGFEFGTGKDIEEKLIKVLESDTYLRAVREWERKRGLGSSINGYGSSSSTAVASRWGESMSNSSLAVSFASDSSFKANEPSTPSKKSKRFSGFDFYRRKFFSPSSPSSSSPSNNPFSTSPPNSSSQLGPLDPNKEPLDPTKGFHPLISMYYLAKEKLERERVYGPGTFANSQASGLDAATHAQTNGTSHSPSPNVPSPIAVPGAELNGKLSAPLPATGSATPTAPPAAAPTNNKADYSMPLPRLPPPANTHYSGLSYDANTPSAVAANSNPSTPTTPSFGQQAHPQPRARDPGLPPISSGVPPSPTKVSAHGTLPRQPPATTHRRSHSLSQRPVSNMPGGPGGTIGRGWGAMFGNGPSPVDENAEDKTPTPTLKAPTPLKTQTPTIIVGGKERPIPDVPSTPMSPQSPQSTHSKVPHTAGPEVTSFADRERAHSPVLSTGATLVRKFGSMLVGKGDERKHGHLLKRGGTPRPSEDVDVSEKEKEKEKEKEREPMSENERVETSEKTDVTADNKSPKSISHSQSQPLAGHRRAATILDPQGRAARHERRSSTGAALFSGSISGGTIGRHRRPSTGYTNQPRPLAERLFSRTEEEDDEALKKDNATAADEMGRVATDGAEEHTDDETLSGDKEFKPVFLKGLFSVATTSTKPPPAIKADIRRVLDRMQVQYRETKGGFECLHMPSIDISSVEPTTPSSRHHQQTSSGSGEPSTPRHGLVKKSSKLSFSIRGGRTKDRDASVDKDRGEHPGRPSGGTTLTATPSTGSSSFFNVSSHHTVVDAETRSTAGASATLPASPSTEIDITPASPTSGSPSHQSKNLPPIPRDFARSPSPMPSGQVPSDVFESMGNNSLSVRFEINIVKVPWLPLHGIQFRRAGGDGWQYQMLARRVLTELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNJ9</accession>
    <name>A0A8H5CNJ9_9AGAR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
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            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1"/>
            <end position="14"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="13784" checksum="721B0B926981443B" modified="2022-01-19" version="1">MTLPSKWSPNTPSLPTAKIHPRTTTSPPPIPHTQNPTPSSVPYRPRSEPSSAPQHPPRISSTRRQSSFVRLRLPPLISIGKAVTLPCGSLGLHTDLPSPLDDHLQEVHGGQRERGVGCWGIWGMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNT0</accession>
    <name>A0A8H5CNT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">D9758_009671</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNT0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="120" mass="14677" checksum="69822C86073AE904" modified="2022-01-19" version="1">MLPITRRIPHYYQYTSEESISDELKDELKDAIDDTVRAYRDYTFVMELWESPEMRQQFTAWLQNEGQLRYDVYRDASARFQEVVTEIESVYGFASTQFIRRARIRLNSRLRYRSVRERRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQP5</accession>
    <name>A0A8H5CQP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQP5"/>
    <dbReference type="OrthoDB" id="3225557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="266"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="583" mass="64617" checksum="EFB6ECA69527A830" modified="2022-01-19" version="1">MYIVWLEAEHKRRPTTNPCPALRPKSKPKTQPKLKAATSRARTKKSERSLWFDPSSYTDIVAGVSNRKKTSARPPVVHVQSDDEDEGEEDGEAESEDEELRESDEEDDKITPQAIILDLEAPIDDSFPNSHNDEMLEDDAFVVPRSQSRASSISLPPAGELSEDDDDEDAGRKRKSPPTEQSDAEDDGPEPKKSRVEKFLSERPQIVSSVTKSLQKTAIPAEKKPVVWPEITEYTPLAAGARLLSKGKQPPHFKALLEKASVNAVALFLFDTAYPDPKKKVQMLTDALTMASSDLQQTDIHKRLLHPAEEKYKKPLEDYIFNRVVHARGEVQKSVTSIILSAYPITGADNEDLPTYLGFLRKKCRYIYPQVITVAEPAKPNLPTQPSTQLPTQLPMQPETQPDFPVSQAQPRNEDIASRPEESPSQAANAPVPTSESSAQRSRVASKIDEKSLKKSQPYKHSAITSVLKTLFAGYSSPGFLYQELFGSTLPNNDEKEIPKAMLAMVASVSGEAARMWPKPSRQTLCEPSTKKHSDLLDKIAANPQKYHRLMADLYRIASGDSDNDGDTSDDGVPDINLDELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQQ5</accession>
    <name>A0A8H5CQQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000465">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000743">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000294">
        <property type="entry name" value="Serine/threonine-protein kinase OXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="427"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="741"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="788"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="861"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1281"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1166"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1235"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1289"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5346145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1300" mass="141738" checksum="E3DFE57C3EA236C7" modified="2022-01-19" version="1">MLKSNMDTAPSRRPPVRVDQDGPWSVSVAESPHDPRSYSLYIKTPTHNLTLTRSIVEIVELDHKLRESTLPNTKLPNFPLDPATLPAPTPKRKSAFLNTLSRLASPTSNKSAKHSTSITASKRPTNGGTPVASPSTESSDPFQSFSASSALLNAALPTPSANSTALAAYFTTLSNSTGVRQARVWKRFVRVRTDDLESVRVERPLKHVRSDLAAHLGMTKDKKERKKEVQPVVTPEEIEKEQLEKNTDVEDVSPQPDVKADEMEVDIQATTSPTTETPTAAKATDKVIDITTPRASEDEPRTPLPQPSTLVPSAAELDSAPSPAADSEAQTSTTSTRVPRSQSADPDRRMSRAYLSSSVSGSQTETSQTETGDESSSVSTSRHPGTRKKKGTTSAPGASSDSASASQPTSKEGKTRKSQRKVIIDDFEMLRVLGKGCAGKVLLVRHKATTDLYAMKAITKRHVLAHQELQHTLTEQAVLRRMSAAENAGEGVKDPFVVKLWWSFHDKENLFLVMDFHPGGDLATQLARWGRLGRDRARFYAAEIVEGVEGLHAMGVIYRDLKPENILIGADGHIVLTDFGLSKEFPAKRAGVNGMNAKSAEVSGVPTAPPTPSGTRNPNEFMSAPWSSPSKDLPSTQMDQTTTFCGTAEYLAPEVIQGLPYSYEVDWWSFGTMLFEMLTGITPFWANNHADMYMRVLQDELQFPDDRAIDQDTKSLLRGLLQRNPVLRICEPRIKRHPYFSMIDWSHVYYKRYIPPYIPPIDPSNASDTQNFDDTFLDMEPVLDDVQDDEEGQDHTDTDDNNENTDTDRTDDDGDEANTTPSQSRSSSAVRPKKAAAAAGGEAADDSVDVFDGYSFKGRHSVLIGSDEEEESEEETDEETDEEEFEGGEIDLSQPPQPKAKPEPELQHRESEQPNQPVPDDVTEEEDVGPKTPEARPVALPPDDSEPVQDEAAATPAKDEATSGAVEPVVETKPRKSKELSGVTEVKEKTEKEAKEAKEKDTKAKPTPPAKTPPAPPAKTNRSTRPRKERSGVPALDKYLSDAPEDDGTTERDDFDDEDDDWDFVEAVDGEERNGARGTSLFARGVVDKYKLAVFSRKTSTPSKYRNGLGSRSASGMSYGSGMSTPPREANEAEGGSPSPSQKRGRNPGLTFRKHPRQFLRPKSPPSSYSPKSSSGTARSSIPSSLAGSNSNTLSSMTSMSTQLSSTSSPANGSGTLAGTQNHSLKSKESAISMGGQSHSSDQSNPDVVTDVPSPSEEPEAVKGQPKNNKLKKYKENAEKMLSLFSASPKQPQPQQQAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR89</accession>
    <name>A0A8H5CR89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR89"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034048728" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="45" mass="4633" checksum="7433B5C2CD3BFF69" modified="2022-01-19" version="1">MFKSLTAIFVLALSATTAVHAIPNRIPENGLCDSIAGPVGTCNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS11</accession>
    <name>A0A8H5CS11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000106">
        <property type="protein sequence ID" value="KAF5346006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS11"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="424" mass="46825" checksum="E60AED162F1D631E" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPPDPLFQNPLPFPLDPIMSDAGENTRTDVRDTVPTPPSSPPSTSTSSVALSMPENTNPNYMMPLSDINKAFDSLTVLTGSENWKMWYFRVNNALRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYIEESDAIELIKKLKQRFDPSSTVQESNELWKLFNLCKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIAQLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAAPYQKPSDKKDRKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS19</accession>
    <name>A0A8H5CS19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS19"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="82" mass="9223" checksum="0CF64C95829E05C9" modified="2022-01-19" version="1">MGCFRSTDPGPEAQQFSSKHRKKHPSERAIEEEFATRDYTKGKDEFGKVRFQYKKSLRSTQGQPKSSEGMVVGNGAGEKPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSL7</accession>
    <name>A0A8H5CSL7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSL7"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="279"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="377"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5346306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="394" mass="44499" checksum="F87B9D443E48BE52" modified="2022-01-19" version="1">MSQLVSPSLGPNHARSASAPPSIEESGILLPPNRFYNEESQRISNMIDDELKKESALRKEAKRKEIKVMLLGQAESGKSTLQKQFQLYYASQTLETERPSWRPIVHFNIMKAVRMILDELDYEFARAENAEQEEIQEQDVDNELLEISPSHKNEILDLRSRLLPLVALHDSLASELSGGVSITGGKTGVFVRSGWQTLLTPSRGWMGNVHTGKPQAVAGLAAKALHTAQEDIRKLWLHPVVRIFVDKRKVRLEESGPFFLDNIERIAQPDYVPDIEDVLSVRLQTLGVIEHSFPINLGGTMYDWRLYDVGGARGQRHAWVPYFDDATAIIFLAPISAFDQYLEEDPRTNRIDDSLQLFTAICANQLLKKAHLVLMLNKTDLLKRKLKAGIRVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWM9</accession>
    <name>A0A8H5CWM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWM9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="14114" checksum="24CD5EF67CDFBDEE" modified="2022-01-19" version="1">MADPSKSKVPSFFPHSHEVYFVNTTVNMVAGSMDVVHNHSDQGRSFRRSRILSQRFSRISEAIPSSTESPMVVPQSNIELRAELASSRHYRIHSGKYKQRLVLVKVFEGTQAKKVGANLSGSLLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWQ9</accession>
    <name>A0A8H5CWQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWQ9"/>
    <dbReference type="OrthoDB" id="2679012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034670591" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="114" mass="12370" checksum="77B1F22236C3766E" modified="2022-01-19" version="1">MQLKAFALLSVALLGAAVPLEDALSKRVPHVYGPDAVEAVDKRVPHVYGPDAIEALDKRVPHVYGPDAIEALKKRVPHVYGPDAVEALDKRVPHVYGPDAVEAFDKRVPQCVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZD7</accession>
    <name>A0A8H5CZD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_012475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZD7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="107"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5350373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="567" mass="63576" checksum="C7373C58E1191604" modified="2022-01-19" version="1">MECLSADVEHSRPLPPIEKFFLDTYTPKMCLDENLGNTLGRTLPYFRQMSTPPTSPIKAEKEDVSIEENAPQHRLDTRLDDEPIPELGTAEREYVERKLVRKLDTRVLPTIILIYIMNYIDRTAVTTARLQGLEEDLGLTDLHYEVILSILYVTYCPAQIPSNMLLNWIKRPSIYIGACVMAWGLVSALSGATQNYGGILATRMFIGLPEAAFYPGTIYLLSRWYTKKELAFRSAILYGGLLTSNAFGALLAAGILHGLEGARGIRGWRWLFYIEGAITIFVGLNAMWLLPDYPPNTRWMSPFERRLAQARLADDAGEADKDNDADSPLKGLWMALKDPKVLLFSIMTTAQLLGLSFINFFPTLTATLNPNFSTTVALLLAAPPWIFATIVCSVNAWHADRTGERYFHIAGWWWGVIAGFIIGLSTMNTAGRYVSMFLMASGYAGFAMTLVWVSNAIPRPPAKRAAAIGLVNGIGNLGNLMGSYTWKAEWGPEYHQSMAISLAALVISTVLSLVIRQLIIRENKKLDEDERAIMERTDRQRVEQAAILEGITFEQAMERRKGFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D271</accession>
    <name>A0A8H5D271_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D271"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54098" checksum="8B315582766E2DD7" modified="2022-01-19" version="1">MEPELLIPPNHLLSLPRPDTSLGLELLAGLVDTTTLAAHDFDVDNRTGFMPPQPPLTRLPEEWEEWELVLEASRGLKLGSRPDLTDEDKEISRIWRGQVQQLPILPTENLKKSEVVVRRAHLVLSWILHFYIHTLPPSVSTVVIPAPLTVPLLQVCAELRLPPVLTYADTVLYNWALKKPQHSPVPNLSNLRSVQTFTGTQSEEEFYLTSARMELRGTEALELMRSTMDEAFVGDNIAMKRITSYLLTLATVIADLKKLLLDVKEGCDPQVFYNEVRPWFMGIDSGKRGWVFEGLELDETLEVPKELSGPSAGQSSLIHALDIFLGVEEYSHSDKITGQAAERSHTFSSFSSTSIPTSSNPAKSAFLQRMQAYMPRHHRNFLNHLRNNPRPLRNIVMHAENPQLLEAYNKAVMSLKELRDAHIVIVTLYIIIPAKQATAAQEEVEKERADGKGGKESLKGTGGTDLVKFLKDVRNGTAGALLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2F3</accession>
    <name>A0A8H5D2F3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2F3"/>
    <dbReference type="OrthoDB" id="2527908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="496" mass="52887" checksum="53E6095FF8AD7CE7" modified="2022-01-19" version="1">MAKGLKCASRRFGLLSFLSLTSTMECPAILFKFLFYFLFFASANAQDGLPPMRIFQWKFSNAGLGFELPSCIPLSITLSPFNPSNVTHGIPPFYMLGHEVGGTPRLTHIGDNESSLSWTVDHPVGTQLMLNVVDAQGSSGGIPPQLYTVVNGQTTNCIQSGNDTSFTVTSNITMGAELNACAPWGLRIKGGVKPYNLTFAQLNSPNITNLTMVPPNADGYTYIQRGNPDHLLLVSVSDFTGRWAFGSPVINPLGVSDCVGLVSSSGNATELDQAQKEAEDAAARNKSNRKTAIIAGVLVPVLALLIGGGIIAFYIRRRRHRMAKEINMGPLDTIPKPFIDEGQILSINSFLDTHSNTSPRTPKTPPGPPGLVGHTVQNSVASSEPFDPYNTTEHSSTRPNSSSSSGRPGFNSFPSSSVRRPSANGKAAEAAMSRSARSDVSNPSTSQAGPSLPPNTTLIPSPDGDGEYIIQHRDGGGVVRELPPPYADRSLAQQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2P1</accession>
    <name>A0A8H5D2P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2P1"/>
    <dbReference type="OrthoDB" id="10394863at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="169" mass="19389" checksum="C749E2B6080D347D" modified="2022-01-19" version="1">MSQSISLTKPCSTESDLIVEHLAQRLHRYQFIFDTLRTGVLSDGTGYWKDKRYCDVVASLDCPSPEELTEQMRTDKELEMMSMLEQKCRKDIISLEDRLNVLSAAFTLSAYVVTVDMKKLMKEQQNMVMQRYNELRKEDNGFGVGAERDQSFIMSPFSALLRQAPLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4R8</accession>
    <name>A0A8H5D4R8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4R8"/>
    <dbReference type="OrthoDB" id="3247499at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5353109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="369" mass="41087" checksum="A59760438531F5EC" modified="2022-01-19" version="1">MCVIRDSVTYTEHAKRKTVTALDVVYALKRSGRTLYGFGRLRSDFIPPMDLTPSLPNEIVSDIFSYLRPASLADLTRVSRRLSAVADHLLYSSIFIKDLISESSPVPWRTSRCCESVLSRTYRASSVRRFHIRWLRDQGFPPTYVHVAPTLARLSETLDFFTTIESLELLLGPADTLRAISHTNDGEIHIIERVIFNHSFPHLQFCSLGAEWSKLSPSFSGILVSFLSSLHSLRQLKLPEHCASLDLPSSCLPSLTSFRGSPGAASCLLPGRPVQFLSLVGQDSDVTRENLLRITQTSLPLKDLDLSGMSVRPVLISNVAAYLPDLEVLKIKLALRHTLHYALSGIGRLTLTATRNWGSVWNGVEPVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D636</accession>
    <name>A0A8H5D636_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D636"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="6161" checksum="2D1E8C82DC97960B" modified="2022-01-19" version="1">MLPISGSSLSNHASGNANTNNGLRRTIPLSFSSPGSGLGSGSGADGQQDHGNEKDGSGGGGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6H3</accession>
    <name>A0A8H5D6H3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_012385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6H3"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5354455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55084" checksum="357281A8B5EA8B6E" modified="2022-01-19" version="1">MIYEGTGFPVLVGVLIIALAILYLRGNRGPLPPGPPRLPIVGNLKYLTVLGKPRPWHLFHRFAQEYGPLTYLELLGKPVVIINSAKAATELLDRRASNYSRPRMIVASEYLSGNLNFAMSNGDIWRRMRRASEAQLGVKSLLEFETIQTDEGILFAYEMLTQPEKRKNNVRRVMASTILSIMYDQPPLRSLDDPSVRLMDEYMDKMRTALQPGSHLVETMPILEHLPAFLAPWKKYAKKNFQKLSSMFLEKYEVVKDKMVSGEHRPSLCSKLVESRSRHELNDLESAWAAAMIYGAGYETTSASLAWFFLIMIQFPHIQRKAQEEIDTVIGRSRLPSFSDMNHLPFVRAIIREMLRWRPPGPFGIIYQSVRDDYFDGKIIPKGSVCIPNIWTINRDPQIYGTDATEFRPERHLTSDGKLKDEKDEGNFTFGFGKRVCVGRYFANKGLFIDITMILWGMSIKPSPNGSGQIVIPSTSEDVGEGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6R3</accession>
    <name>A0A8H5D6R3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6R3"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20742" checksum="656EA69A20A3D14E" modified="2022-01-19" version="1">MSDWGRDTPPEASSGVFVSATSITIDAPPEKVWSTLLDFKSYREWNPFVRHQVLTDASRNPLPESSQEPSPGKYVYMNPVHLPPQMDKPSLPWQKNSTLVVITYLNHETRRVAWRTASFPRFLLDAERWQTVSVGDDGKTRYETYEVFRGPLAYVVNFFMGKHLHQAARAMAEGLKARAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6T3</accession>
    <name>A0A8H5D6T3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6T3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="284" mass="30867" checksum="4AEAEFD5480EE816" modified="2022-01-19" version="1" fragment="single">MAIAYMPKICFKLLSVSLHLSMHIIDRQAQSIPSIWMNADVTPSTTSRSSRAQSPDSEPKMSNGNGNDFGKSRTTDDNDHDADDTMTQTNGLGFGIGIGIGIGIGNERVFSPPLDRSTSYPTPIITETSILRPNRYDETKEEASNNDIHGYLQSPDSMLSPSSAKPVTSPSATSPGPVSSSSAGPRSPLARSNSKSARDKFKTFSRRISMSGMGFPFQIPGHGKHGKEGKDGIDKDKDKDKDRIEEDGDGDGHGDEELEGIHLQRLDEEEMGYRVPRHSIDDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAK4</accession>
    <name>A0A8H5FAK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000343">
        <property type="protein sequence ID" value="KAF5329831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAK4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="81" mass="9047" checksum="65E252A892D5267D" modified="2022-01-19" version="1">MKERPSTPCQLINLSGLYSTRVKVEQSFHSGTRLSVPAQIPKFSETTSSIRHVTSQPASPAFHHHHDSAKHRLNPPKIVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDQ7</accession>
    <name>A0A8H5FDQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of ploidy protein mob2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000293">
        <property type="protein sequence ID" value="KAF5333011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDQ7"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28314" checksum="9C7F22908F615297" modified="2022-01-19" version="1">MSFFNSIGRSMTRAPRGPKRSPTPTSATFPPEVTSNGSAPPSPVSSPNKPLYLCSPFVEAALVKGNFKTIVMLPKYVDVMEWVAVNIYDFYTNLNEFYGVISECCTQQTCSTMSAGPTLNYTWINQDRKSVNLPAPTYIDYVMTWVQNLLDDEAVFPTKSGQDFAQTFPSTIKHVYRQLLRVFAHIYHAHYHQILHLRSEPHFNSLFAHFLAFGREYELLEMKDVRGAASTPVGIGALWERWRDMGILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIS2</accession>
    <name>A0A8H5FIS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000200">
        <property type="protein sequence ID" value="KAF5338112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIS2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="165" mass="18429" checksum="1C7BAE295D131CA4" modified="2022-01-19" version="1">MSCLNLDEIVPKDIPVFLNITMKFSIVAILVFLLLLSSVSVYFFFEMLFSKGPWKRSTARRDLEARDSNDRTVAYPFYHAIYNPSDDLSQPPSTYCVHFDANTSSQVTVSDNADIMLNVRQLMKSRVAEADEKEKVTANDSDGVEGVGHGQLEESVPLLNAGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKF8</accession>
    <name>A0A8H5FKF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKF8"/>
    <dbReference type="OrthoDB" id="5076166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="186" mass="20747" checksum="FA0E0F51BD4805DB" modified="2022-01-19" version="1">MLSPTTISAFSPVSPVWLLALVAVAAGAYRWFKRISIKHIPGPVDEATFGVVRNLPNLLQKQVGETEFRWQEKYGGIARFKGPLLEDRLFVCDPKALQYILQVSGYKWPKTRERRAASYLLVGNSITFVEGAQSLCLHGDVLLGAHICAHVSPAYECTVPYRPHCHAFEGHLYRGPALWDTAPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKU1</accession>
    <name>A0A8H5FKU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKU1"/>
    <dbReference type="OrthoDB" id="2958007at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="27783" checksum="5C06A742112762EA" modified="2022-01-19" version="1">MTLQENQIELDEASCNYWHMAALIFLVFDHLLTLDTEVKCLWKRPSNISGYLFFLHRYISPLLSVFAFDLDLPMRYSYIAHFGTYYHQSGHSQESDTCLTQLDTASSIRQAVAWEMLLVYDILLFVLAFHHAIKTRNELRILRNRVSLQVILLRDVGHSNHYLDQYHVTGQSGEHFDLLWLYERRFITSCEQAVDVGIYASQFTTQLDQQVETHITFARRQNVNRSATDTENLAIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPB4</accession>
    <name>A0A8H5FPB4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_013897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000122">
        <property type="protein sequence ID" value="KAF5344605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2025"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2364"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5344605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="3107" mass="354762" checksum="EF4837907CAF3F18" modified="2022-01-19" version="1">MIQYSKSHSSSHPLFDLPVMSELEYIIHHVFLPPKLPQKDDYTIENEHFLCENVLTSFKGFVQERGRSGDQSWFELEAMLGAISKSQQSESLSVSNIKASFSTMREGSVRAFLIRAQNAGVIVRRLSGEVVVESFEVTPPRKVVMQGEGKILRTFPGPAISIPNTSFNDPYFREEFSSFLAQMNSDVLDSVATTQKAGSTVVEEKDSSHPRYITTLLTGILRGIGKPAQVTRISKRMADEVLMGGKGKPWRRSMIWIVLRVTLQTNLPEYKVFMIHFMLDTLEQAIQAKCDSELLSCMSIKIAARVHKLQDSIPGPLVARANIVTSKMHDLCSRRWKQVQEAQTVPLPWNPEALRSNARSDIVLSLKNSRDFITKVLDNKDASPSSSPFIPNEAPRPLRNLQAFERYSDKSTLEDALSTDKSLGLADLELSLQGNLNVWVSQHLTDSDAPGVLFNIFMVYLSISRGHYGESQEDVSIMMLTLLELWVALDKVVVAVHPLLADYSPEVPTELFQPLLLRKRSFIEQLIRLLGHIRERHSHATRGTVFTDSAGTSSFAVRFFNESVTLQRLKKTIEDDAGRQRDAKREEYRRLRSEYLELVSKARRLSCTYYEYEDRWGCRRRSHSSYCEKCSLERSADRLEIYVHEWPLPEDNIMAMVSVFELNCPDAFNCWREATYTFLNDLCMSSEESGRRQVQSQIYDRVYSYVGLERWKGLNGNHERRITLASDTASFIRTKYAHIEISKAVSEDNVIVNNGLHYQLYDKNTNKWAADPFHNLDIASMCILQLSPGIYSSLQFSLNSTTYTPNSVISNQYDCHDRLSLHEFIPFGSLRCGHRLQWLNVLKELRARNLTFYKEDVHLLLAQAAWQIGSVSASDTLEWHEDLLCPHFSRSLIEELTQLLNDISSNWMELPTARSIILLCCRLLEGSESKDVQKNIYTLIRSARETTFGWLKSFASEQPIGQDSTRILERQHIICEMAFACRSTYDVGRRHLESLMISSEDVSVFLECSIRLFDDTPASWKALPLSLQRLHLRDRRLSHFVEQLLLSRIKGDRQGVDCAIGAIWPAFRPGVPWRALEYPNERWVDSSTKPEGQSSSQIVHLNILEGRMLIDGKPLSRLPASITEHSTFTRIFGSRVLDIIPSDSGLDYATRSTILGHQVHFSLRSTVLIVLAKHLEENRVLRLIPHLVLSGDFPELLVQENVHWLDLERNELEFRPLTSLWTACSKIWKVQFVRNGESFAIQENSPSDLTLVDVRSSTFKMISDWLRPLERSRYLTITRTTANQLQVDLPRFRLSFYLNEAGDLECVNFPGMVVDWDQSIGTLVGLKNMLVLKPSIPSQPRRVLIPDGRIHFSIKDSGHHVKTAIDAPSRHARFYEYTIRTDIGCLEGDGSLRSHFYKAYLHAVTSHCLPDPLTRRTGTHESLLVLTSARSLSFQKVQSEDLEILYWIQTLTAKRTFYPQKMTIMQAIEWNDLPVLSQHPLFFFTVQDILTYCEHLSQVRGECVSLESSEGQTDRLVRRDLYRNFRCYAKSGLRVEDTGHTTMDYSYQARDMELLDEKRIFEISSSVSNGISSPRVQLIDILRRWSDRYGSFQGPRNSSSSTSGPSLSYSCDWFLDALLSKNWLTLYNLCRDPTISRVRKRYQLIFSLSALAYTNLSSEGADCHALIPVLVQFVHNTQFAGISPPPHSSYTLSDGIEPTRKQVQELLESSCKPLEDTPSVDLVRQWREEEYDYEKRRQKDYNQERRLAVEAVTRYLLNQWPLTANSLSGPSSSAVPRVTLLLPRYLQDATKLFRSCRRNGELTTHIDTIQAILDRTMTVESVPAVAYTVEPLDRRLRSHTPLPTLKGLLPLREPPGLGSANFAGLKALVSHLASPQDAVHQCFSRDLDQSAKALASRQSAVRYDNSGLLLHDGESFRVYVEKCLTEMENSYNLITSVLLPSVEGVERLLATTGLWPSMTPQTLLRLLSFDQRGQLRPEWVDSIQNYGKSIIQYQRSMRLQYLHSVNDPDGVRKEMHNDRPIGLSDVDWLLIQITGNFLARDIQVQVAREMMNPSNFANSVLQLNMGEGKSSVIIPMIATSLSDGNKLVRVVVLKALSPQMFQLLVDRVSGLANRRVFYIPFSRDLKMDINLTKRIQDLYQECMREGGVLVVQPEHVLSFRLMGLDRLVSGQPGTLDTVSRNLLDSHRWLCQHSRDILDESDEILHSRYQLIYTVGKQCLLENHPNRWIMVQDIFMLLLRHAKDVQGLFPSGVHVWDVRPGEFPIIQIMEPDAEEELLSRIMKDIMEEGRLSSYAFERLPKEVKGEAYIFIRRRDVDQSQLSRLLRSCQETAIWKALLLLRGLFAHGILSYILRQRRWRVDYGLDQRRTLLAVPYRAKDVPSLRAEFGHPDVAICLTYLSYYYGGLTPGQLDSCFEILMKSDNPSAEYAQWARDTSPDVPPTLSSVNLKDPAQRLDIIIPHLSRNHSVINFFLSHVVFPKYAKEFPKKLTTCSWDLAEVKTYVTTGFSGTKDSHWLLPATISQCDPLNQEATNAQVLSYLLQPENNQCHCAKGPDNETLLAEDFLKLIVSQPLQIRVLLDVGAQILDLVNKQVAKKWLLLHDDVSVSAAVFFDEGDRLMVIDRQDNVEPLMSSQFKGQLGKCLIYLDDAHTRGTDLKLPREYRAAVTLGLKVTKDRLAQGCMRMRKLGHGQSVTFFAPFDIDQKIRHNAGLDAQAPVSSCDVLKWACEETIAEIQHYGPHWLKQGIDYIERKKAWDTFNSSLSSSDLSPWLQREAQTLEEMYGIGDKENTFQHVDFRTEEYRELDERCQKLGWSLAQSASQTTVDEEQEREVANEIEVERQVQRPPRKHPETHHIDPEVERFLQNGIIPASAQSKSFIPLFRYLPVPFIPNRRVWSPGLLCTVDFARTIKGLEPAIDDYMRPVTWIVSGGYVADSTVVDPTPALVIISPYEANKLRSDIANNTAGLHLHLYAPRVTQSQCSFENLRFHVIPPLPPSWTPPERGMMTQLNLFAGQLYLRDWETYRELCVFLGLHLPSQDASERAEYQSDGFVKPEHRSRAMRVLCPFQSSPLPALKELFGSRRKGSGYNLTHIGKIVRGRVLVQEDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPS6</accession>
    <name>A0A8H5FPS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPS6"/>
    <dbReference type="OrthoDB" id="2668963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="27889" checksum="AAAF13F404E51D7F" modified="2022-01-19" version="1">MDTLYAKAVTLYQAEHGPGVTEEVLGRKPHGLRKICIIVENEHYEQTKKALPKHLSSSTLLCLVNGGTPKNLSNSSQGWLLQSEEKIVIDYALELASRGFPLTHQRLKEIADKICRSRLGDKFSEKGVGRNWTTHFVEKHSSRLKMFWSSNLDTKRGQAVNPFMNEEYFKLLKEVLEGRKDHEFPAAVVDTPWELEIDWEEILIPALGPDDAEIMLPEIEESRKEAAEGWVDVDETERVQSFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPU0</accession>
    <name>A0A8H5FPU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPU0"/>
    <dbReference type="OrthoDB" id="3133286at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="234" mass="27084" checksum="792811865DE34F06" modified="2022-01-19" version="1">MPTGPPTPQEVRRAARAAINIFESNDMACCLFGSLACHVYGMRYRDPKDVDLIVLKDQGNDPEELKQLLVASDDRFYLIDSINPDATYKVLYFSLLTNRRGRQRSCKVDILTTGRTTTLNIPPVPPECITYVAPFTKDDNRLPVMPLLALLMMKLQGWADHKHSREGHKQKKVGQDVRDVDALLEIVLNEWDVHLENQEERWLPRWFVKDSKERVDEYLKKFPGKKEGWERLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPW7</accession>
    <name>A0A8H5FPW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPW7"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12433" checksum="D00C542A1A47EC5C" modified="2022-01-19" version="1">MRYLTMSLHPPSCYIFQAVMPDVLHWLGIGVNGHESIDADGKKRGRVDNMVLMSDTKYDVVVGSGIDVGRKYELPGVVVYYVAWVQELKRRFPGIIPMQAATVGRGWEVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR57</accession>
    <name>A0A8H5FR57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR57"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="60" mass="6379" checksum="F159A9574E2978F1" modified="2022-01-19" version="1">MIVHDGIRTNPGLYPEVEAKEKAVGIVVTLNKGLAGLIGPELSKLGVSAFAYTHNNVTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRM5</accession>
    <name>A0A8H5FRM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRM5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="15636" checksum="2B70FB1E958F0325" modified="2022-01-19" version="1">MNDSGCSSGLLMGGTSQLKDADALKIRRKFEGRTTCGQIFASFPLLCQSPFPSKRFPDPVFRLHPNPEPKSEAASTLEDASDQRFLSLRNLPKTVKLASDTSSGSPYLCYLSVHMSVAKTLCMKANASYIQKYSSDFMTTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRR8</accession>
    <name>A0A8H5FRR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRR8"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="563" mass="63825" checksum="D0E2F3E2A9E6C8A6" modified="2022-01-19" version="1">MGNVLAPYKRETCTVADLGQLGSLKGLLLSRPETGEPLVKRFLNVPYMLPAIGVYRWRRPRPLPPHYSYSPNDGGPRDCTEFGPMFPQPQYTTLQSHDANKYSEDSLTLNIWTPSGTPPERGWPVMLWLHGGWLQVGDASIDPDMDPTELISKSGGNLQCVFIAPAYRLSVFGFMASHELEEEAAVVKEGAGGTGEIAVGNYGLWDQYEALQWVYRNVHHFGGNKDEIILSGRSAGAYRTHAIAAHDLLMKKEEECKYKRLVMFSNAIPADPKTISEVQPQFEELLTACSIPLSLSGPKKLAALRAIPALELVDKIMTLESHTFRPVRDGVFFPHDLFKRFHRGDFAQEFKKRGMKLLIGETRDEETLYRQINPPDDLESLYKQVGNYYSPAVTKVVIDAYYNRNLHAQSAHPDPDPDIDSWKKVYGDIISDGQVRAPTRLLIRQLTSAGVPLSHVHRYLINFRLSCINKRAPSTFGVSHASDKPIWNFSIFHGLTPEEEKTMRAWIDDFRKYIWGDLQEVEWGTKDWDEVKMLGPSGEIEVVKDEKWRYLIEVGEEMSKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUZ7</accession>
    <name>A0A8H5FUZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUZ7"/>
    <dbReference type="OrthoDB" id="3113889at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="197" mass="22316" checksum="72B4B1216930214A" modified="2022-01-19" version="1">MYKRFRRQRRSILDPPMLSSLSNLCSIALQRICLVNLIVIRQITVYGKVEEAVQHQSVAQSLMIELSRSRKRNITILFAFLGYYAQLAQITAAEWIIFLILLSSSISAFCDSISPHEFATIRPSLFAFLHTIPSVSVRVVLVAEMIRVSENLAMLVCQLCLALGIWCLLCLLKRPERDESSGDDVRLEDGIISQTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV26</accession>
    <name>A0A8H5FV26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV26"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5350201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="474" mass="51965" checksum="5AC2B414365206F9" modified="2022-01-19" version="1">MSTLDSYETTPLLQVPAKKRTPLPWTQIIVLVLVQIAEPITSQVIYPFINKLIAELPITEGDETRVGYYAGLIESLFFVTEALTILQWSRWSDHVGRKPILMIGLSGLTLSMLFFGISKSFEGLIISRCLAGLLNGNIGVLKSMMGELTDETNIAQGMALMPVTWSCGATLGPVLGGWLANPHERFPSIFGQSEFWREYPYALPCFVAAGYCAFAFLLTLFCLKETVEVGKPRDQTLVEENALPTRSGEIPLSLKQILGYPRVVVVVVNYAFLAFLDIAFRALQPLVYTTSIPNGGLGLPPPSVGLALGAFGLASGLFQTFVFVYIYEWLGPKPIFRLSISTYLPMFILFPLMNLSAMHNGVNWLTWVEIAFQVSFYVLMDMGFCTINIYIRASAPSNRSLGATNGLSQTSASIARAIGPALSNSLFAVSRQHNLLGGHLVYAVSAVVAGCAIVMTNYLPKDIWHQESTESDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV33</accession>
    <name>A0A8H5FV33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_007819</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV33"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="396"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5350231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="765" mass="87439" checksum="F87DD3040F591393" modified="2022-01-19" version="1">MSGVRQRHTQISRPGHEYERAQEEEHADDVYQNPNLRHPIEKLLETDRASTVVVAVLTTLAFALRFYKINQPDQVVFDEVHFGKFASWYILGEYYFDVHPPFAKLLFGLAGWFSGFDGQFHFDNISDSYTEHHVPYVGMRALPAILGSLTVPVVYAIMKQSGYSTIIAAFSASIVLFDNAHVAQSRLILLDATLIFFMSLTIYAYIRFQKLRYREFSTEWWGWLLATGAFMACTWGSKVNGILTVFTIGIAVLIDLWKLLDHRRGSMDYFWNHFIARSIGLIVVPFIIYLSFFYVHFALLPTSGPGDTFMSPAFQETLLGNEMLLSSKEIRYYDTVTIRHKDTKVYLHSHVERYPLKYDDGRVSSQGQQVTGYGHADTNNDWQIFPTKAIPETGSGRVVRDGDTVQLLHVNTNSFLLTHDVASPLMPTNQEFTTWPKDDYSRHNETLFILSLIDADGQAWKTKAGLFRLVHAKTRVSMWTHSKQLPDWAFKQQEINGNKNPTEKTAIWYAEDIIPNENEGDDERFQEQPVKVPKKMNFFKKFAELQLLMLQHNAGLTASHPYASGPINWPFLLSGISFWTESGTQKQIYLIGNLIGWWTCVVALSIYVGILGADLLARRRNHDPIPEPVRNRLWNSAGFFFLVWAVHYVPFFLMNRQLFIHHYLPSHLASALIAGAILQFVLSETVNYPISVRGPKTQPRVRQYSDIGIKGPIILGVYCFVLFIMYAYISPLTYGTPGLTGEEVNSKRLLSSWTLHFAAKTTQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW71</accession>
    <name>A0A8H5FW71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW71"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="591" mass="65725" checksum="FE52CFD7ECAC6E6C" modified="2022-01-19" version="1">MSFTSYFLPWLNINLIHSKQSQPHPTPDPNVADSILDLLQVSSNEIISQVILNPQKADPLESIQSLLISSVWAPITYGPSADGMRDGYLLLAAALSLASEIQLDKAPEKLIALRKLQAGTTDGQTTVEDDELKEAEDLTRLWVALLNTDSLLCAGARRNPSSHGGRRRGMLAKYFEIFPLSIDVLSPDVMKCRDARLHLFGRVLEEMNLGVSASLNAPGDVDGWYKQIFDALDFLRISKRLVSPLPILVEHDQFYFRMLEIVLCCCRLIVLQQSLHAARLLFTQFAESDASRASLISPSNSHSSKTPNKHDIMYLWGGDARPLSGNILILLLDADPALLGTSPDYVFHMISFTALFLITYKLVVWNAKGPEILEAEDILLKKVMELLEKTSRVRGFRTGLTAGIEHPAKRSSMLIGGVLGLWKNKEKLAHNRRQKDRNSKDGHADMGTSARVHPSQPSQSYTEAVDVTPGTSSESPSEYQLHAHNMHTPAGQFSTHPGLAYDLQTTPSSDLYTSLSPPTPQLPQNPQSIYHPQTGLSQTNHLDMDQTLSNYTAHTENYAANGWMESALFQDPHFWNEMWNYQAPPSDDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX77</accession>
    <name>A0A8H5FX77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX77"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="322" mass="35885" checksum="13FEEF14D48EA1F8" modified="2022-01-19" version="1">MVKKPEIFLVLGGDVFVGRHVVERLKARGDQVSVFDSTQRHVDVPFYHGDIREKAQILDAVKESGATCIIHTISPLSIRNQENPGIFHEVNVEGTRKVIEAAQEAGVHNIVYHSSSGVVFDGHDIKNGDENLPYVKNPPSPYTRSRISAEKLILGANGKMGLKTACIRPSGIFGVGDQELIVGAYQTWKNGSTNVQFGSNENLVDRTYVANVALALVLAADKLENNEVAGQVFFIANNEPCLFWDFMRNLWDGFDQAFPNEAHPGNKITVIPRFIALLLAHVTGLVAWLLRRDPPLLTPYTVKFYDGKRVFYFYKSETTTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2X9</accession>
    <name>A0A8H5G2X9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2X9"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="552"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5357340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="674" mass="74595" checksum="ED4CC3F271D94AC1" modified="2022-01-19" version="1">MADHSRRPNLVHFASSSSSIPEGAMTPRSEHEHDSLLPDLERLPGSGTTSTSGSRTPSHYGTTGNKAVEKRQKLKKRVQYYIPSFAWIPNYTLSSLAGDILAGATVASMLIPQSVSYASSLAKLNPVTGLYAASIPAIFYALLGTSRHLNVAPEAALSLLLGQAVDDVRHDMDDPHSPEADAIALSVSTVITLQVGLISFLLGFFRLGFIDVVLSRALLRGFISAVAVVILIEQLIPMFGLVPLERVVHPATTLEKLLFLIENMFTHRNPFTTLISFASLATLIFMRLFKNMFKRYWFIYRIPEVLVVVILSTEYFEWDKHGVDILGSVNVKTHGSFIQSPFRGATMKYLRRTSSTAVVSAVAGYLDSMVAGKQAASRFGYTISPNRELVALGASNLAGSFVPGTLSAFGSITRTRINGDVGGTTQMASLICSGIILLATFFLLPWLYYLPKCVLASIITLIVFSLLAETPHDLHYYWKMSAWMDLTLVFLTFVFSIVYNVEVGIVISLIISLLLVVHKSSRARMTILGRIPGTDRWKPINEVPEVEEDVSGALIVRIKENLDFANTAQLKERLRRLELYGIDKSHPSEDPRRHEATVLVFHLADVDSCDAISSQIFYELLEEYGSRGVGLYITHLRPKVRETFEKAGIMKLLGPYAIQENVADAMRDVNVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3S6</accession>
    <name>A0A8H5G3S6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3S6"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="17548" checksum="B2C2D1CB16AD3AA2" modified="2022-01-19" version="1">MKAAAKMADAYLNAVQNASGSNSLVNGISDDSDVPTNNIKKPRKSKATVADEEPVETVRKELKDRHPEISTADLRKVIAEQWAKMTAEEKEPYTKQASDAKQTYSDAKAAYDARSPDEVAAANAAVADAAASKKPRQSKPKADKPEQKPVSIKKACPVPSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8R6</accession>
    <name>A0A8H5G8R6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8R6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712839" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12504" checksum="ACAFE854398C9368" modified="2022-01-19" version="1">MMGSVEFSLALLVGFDVSFRSATSGHNDDERSWDWSVHKEMARKSFKVLLVKMPLSNRPVWRCRKCGWNKAVEANEKSPGLPVPSAELNPLYKAAERWYGPPSVVDEPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAF9</accession>
    <name>A0A8H5GAF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAF9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="533"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5361289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="602" mass="65724" checksum="1E88C04B2536C9C7" modified="2022-01-19" version="1">MNDTVYDILFAGGGAAACLAAGRLAAANPSLRILIIEAGEHTKNIDAHIQPARYFSHLAPTSKTVTFNVGKPSEKIGGRSLVTPSGRCLGGGSSVNFTMYTRGAASDYDDWETVHENPGWGSKDLLPLMKKTETYQVKPGEATHGYSGPIKVSMGGAFTNVGSQFLDVARVIDKDRGPIDDVNGLYKCNGYGTWQKWIDAETGRRSDVPHHFIYNQEDNKNLVIITGQKVKRVIFEGDKAVGVEYVNDTVLKPNADQTVKTVHASKLVVVSAGAFGSPTILERSGIGRKDILEKNGVPVKVELPGVGENYQDHNVCFIPYQASEDAETLDALFRGEKAEEEKWLKEWSKGKGLIAHNGIDAGIKMRPTNEDLKELGPEFEHRWKTYFENAPDKPVIWVGACSCFLGDITVAPPRKYYSVGYYTQYPVSTGSVHITSAADPNASHDFDPGFLSNQADIATLRWGYKKAREIARRMSSYRGEYLPGHPNFPSTSFAFCKEGQDGPVALDAPIIDYSKEDEELLEVFNRRFVQTAWHSLGTCAMKPRSKGGVVDSRLNVYGTTNLKVGDISIAPGNVGANTYSTALTIGEKVAVLIAEDLGLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GBF5</accession>
    <name>A0A8H5GBF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GBF5"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="197" mass="22089" checksum="F82D767854A6FD1A" modified="2022-01-19" version="1">MSFRNPKQPKPSKDLDVSHVSGNVSEDIKRLLAYPWESLYLGEDDDGQWRWWGYNSDLFKRTKVTEVSVEKNALEAKKYTGKVVCEIDVERDMVNPDRVLQGGCTAFLADMCTNLCLFALAMHAGGEQNSTSQALNVIYHAPSPLGDRLRITSTTISLGARTMSARVEMWSIKYHRLIASAVHMKMLPSVPAPKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GBI0</accession>
    <name>A0A8H5GBI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GBI0"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="515"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="784"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5361680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="970" mass="105454" checksum="C30198757F6524DF" modified="2022-01-19" version="1">MICRLTAKPFAMLPSDIVTRISNTGHGSSGLASPLTPSEAFDSNSHHAEPSPSASEILHSHKDLNSPSKESPLDMNAEENVAGPSKEGEEISKKNPEVRVSSQDFPPSPPLTRTNSVEDSGAAEELDITEHRSREDWHPLKNESSHRESQITASNLDSDAEEGLERRAPSMAALDGEGDSVVDSNGRVLILEDDPEGSRRRGSHLRIEVKQGSPQPWDLVEPPSSGNEKARNPYGTVTSSNKFSTLQDSARGRSLVPKSSYYSGPPGPDAAYGTSPVGQIGVHHPREILRVERDYTGGELIQFAPIYPIELDGRITPTQFLESINAINELLISAHSLRHAILDNVLAVCTLQLSRVLLTSHYEKEMTRLQRLFEELNEEVFNPVGLNLLWPRRVAFLFLEIEYYFPQSGPTYGSFANGVNPQSINQFSFPNTESPPSQDNTPSPNSGEGSSKQSPPEMTDDSGEPALKRKASDEDMDEGPSQKNQHTAAHSTLASGSRRSSTATKRKSSGANPDESRLLKRKEQNRAAQRAFRERKEKHVKDLEDQVAALEAKNEQANNENENLRDLLSRLQSENMTLKQQQQIQQQQSPGVGSSSFTFSVPKNAGSVTSASAALKDPTFQTSMFSSLPRFAYSPPDTKYSNPLDMTSMMSFDPSVLNLLEEPPQPTATASAGQMDFNFGPQNNFEPSNYTTIASNPAFFSLASAFDHASLPNSSPNPSPSPAATSSSNNDHSSFGFDLSSLTAWPTPMSQDVGTLDDLFGGFLNPPMANMDFSFLSGPSSSTSVSPIVHHSNPQFTGHSPSTSASSSPASHGSEPSLFSVRESSSSESDAGHDEPTECPKTRQECTERLANSGPSMFAPVNTSIISKPVSPVSVMDHEKSDMALLQTIACQKGTSSFPTTEVNEHNVEVLSAWRSITRDPSFKECDINSLCKEFTSKARCDGSKVVIEPQGYQGILETLAAQKQQHQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHT4</accession>
    <name>A0A8H5GHT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHT4"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="1">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="29827" checksum="C1D5676535415214" modified="2022-01-19" version="1">MDADLANTIMDADKTMQVFYDGFHAASPEACAFYASSPAEIQANVEALYASIRAQPVPVFEGDDSFGILTYDNLRSFVFEALKSPQPVLFPMMAAAFAELSAGNATGLSPILSGGGSEIGDFDSMINMISIYCSNAEPSDLDASQLREYMSNINSTFSGMFSLQIMTCCVVFRGWRVHSEGRVRGPVGDNTSSSLLVIVNTADPVTPLSAAKKMSASFPGSGLLIQDSPGHTALNFASNCTFQHVAAYFANGTLPEEGTVCSLNDPLFPLVNEATNSTAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM39</accession>
    <name>A0A8H5GM39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM39"/>
    <dbReference type="OrthoDB" id="3265539at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="32115" checksum="7902BA314A3BBE98" modified="2022-01-19" version="1">MSDDSSSTSRFAKLNDSNYAAWSMHMEAELIRKELWTDVVEVMIDQVDDKGKPRKQEDIEADTTKRLNARLMTKMAQARAEMILRVEPGQLSHMHSKDPLVVWEDLKAVHRARGFAAFLSLKRKFLTMKKEKGQKMSAWIGEVKSQVFEMEEAGLMVPDLDIILALTMGLPSSYDSLIINFNDTPSSDLTLNHVMTRLLAEETRQLTHTIPTPQTTITTNAKDLLHNVALSDNKTSLPVEQITCWFCDEKGHYKENCEKRKAWLESKKGNAMMVEDVDYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM76</accession>
    <name>A0A8H5GM76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenylalanine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM76"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="77164" checksum="5E3673DDC065071A" modified="2022-01-19" version="1">MSSSPTLLAKFIQSHKQLDSYRNGEETVKVDGQTLSIAAVTAAARYNAPVELDNSPHIKDRVTKSRAVISKKVEGGASVYGLSTGFGGSADTRTDKPLLLGKALLQHQHIGVLPSSDTKPLDALPLLDPGSSSTMPESWVRGAMLIRMNSLIRGHSGVRWELVEKINELLKANVTPAVPLRGSISASGDLSPLSYIAGALVGNPSIRVFDGPATFGARKMFPSSQALAAHNIEPIALASKEPLGILNGTAFSASVASLAMNEAVHLALLSQVCTAMGTEALLGTRASYDAFIHAVARPHPGQVETAQNIWNLLQGSKLAQAHEEEVALQDDRYSLRQDRYPLRTSPQFLGPQIEDILSALAAVTQECNSTTDNPLINGSTGEIHHGGNFQAMAITNAMEKTRLALHHIGKLLFSQSTELVNPAMNHGLPPSLAATDPSLNYHTKGADIATAAYCAELGYLANPVSTHIQSAEMHNQAVNSLALISARATLNSLDVLSLLTATYLYILCQGMSLSLFVFILLSDSLLALDLRVLRKELDQGLKTILSEEFKSAFGSAFDSKEDSIVDRLFHLAAQTLDKTSNMDAVDQMTAVASSSVSTLVELFTSQPNDQLTSLCGSIPQFRSSVSSRLTDLMNKLRRCYLSGERGPTPASPYLGKTRVVYEYIRVALGIKMHGETNFAGFSAEPGENESIGQNISLIYEAIRDGKMQEVVVNLFESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN01</accession>
    <name>A0A8H5GN01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN01"/>
    <dbReference type="OrthoDB" id="3360976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="124"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="247" mass="27760" checksum="7DDD7B93CCDF6FD2" modified="2022-01-19" version="1">MKLYLKDNNFYPILSNTYYDDSGKIVYKVHTPKHMGGTTGTTTITKVLSSPEDYSPAFMPRRRDTTTEPSAQPANSPDSDIGNQEFAIGDEDPETLVDFPVSDANSGPGPTPPSPSSDPSYRFEYIAQIDWSVVKSARFRFGDGEGKQVLATEFFRKGKFGARGRDRLFTASDGVEYKWILGTRVPELVTNDPSKTSIAKLHRVMGGIFNKSKESRSYLEVYPEGEHIVDEIFTTFIYIEKVRRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN75</accession>
    <name>A0A8H5GN75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN75"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="130" mass="14666" checksum="D53DE5767C0AC235" modified="2022-01-19" version="1">MDDIFGGIDERMEPHVSQWLKSGQGLMAHNGIDVGIKLRPITEKKFQILGPEFNETWKDFYENAPDKAIIWSGMVNGYLGSTSSEIESDFAKGVKKCIASCYVTYYPLNIGHVHITSVAHSGWSRFDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNN0</accession>
    <name>A0A8H5GNN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNN0"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30246" checksum="92FB49B6E38248B6" modified="2022-01-19" version="1">MTKMAIENIPVPKDTVAQAYLHKVPSHPGVFCIALNRPKSKNAISMQLLEDLRAALRQAMAEKMLNVLIFYSSSSGAFSSGADLIERQSMSDEQVRGFLSNIRDIFNEIDSLPFPTIAAIDGPALGGGLELALTCDFRIAASDVTRISFPEVRLGIIPGAGGTQRAPRLIGMAKAKELIFTGRILTARDAKDLGLVDYVASSSSTAFERALELAKEMSFSAPLALRAAKTAMSRSLDMPLDEALNHERACYEPLLGTKDRMEALVAFREKRRPVFVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQU2</accession>
    <name>A0A8H5GQU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_002766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQU2"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="227"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="484"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5369358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="555" mass="61923" checksum="EF35E8187F26A572" modified="2022-01-19" version="1">MSWKLGRSKKSSVTNLRSEDAVTGRSTTPTPGNPDGSPRSGLLAIRVLWAEGLGLPTGTTLPPAVQNALASQQAKVAASVSPSSVQQQRLAKTRGGSAGNRDSIQRTQCWWLPYIVMEYEVNQVLITPLGGDLEKPLYMYQANFDVSRNSELSLQCYLRADEPKRGGDGLADDLGNDLFLGGLKFVPDFENMGNQDQWYEMNSGSGKIQIGVSYTPNYGASLTIDDFELITVIGKGSFGKVMQVRKRDTGRIYALKTIRKAHIVHRNEITHTLAERLVLAQVNSPFIVPLKFSFQSEQKLYLVLAFVNGGELFHHLQREQRFNEERARFYSAELLLALEHLHELDVVYRDLKPENILLDFTGHIALCDFGLCKLNMKDNDKTNTFCGTPEYLAPEILCGQGYDKTIDWWTLGVLLYEMLSGLPPFYDEVTDTMYQKILNDPLQFGADISSEAQSILTGLLNRDPQQRLGVHGAEEIKSHPFFRNHIDFNLLKQKKIHPPFKPSVASPVDVSNFDTVFTTEAPVDSFVEDSNLSQTVQAQFSGFSYNGTNIPISPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR80</accession>
    <name>A0A8H5GR80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR80"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="38590" checksum="5C0F1D7F5B6A902A" modified="2022-01-19" version="1">MSCPDCFKGAVLDGEPTGSIDSSTGAYFAPGPEGNTSRAVLLFTDIFGLGLKNPKIMADNFAKHLECDVWVPDFFLGKPPVSPDAMKMPDPGQKVSMLRLFWTLLPHLPSLIRQRPSVADHRFIEKLKSEKKYTRLGAVGYCFGGSMCVRFGGSGLLDSIVICHPGNFSQKDLNAISIPCSWACAEEDFTFSPETRANTEKCLKAREGKNNFVDYEFKDYKGTVHGFAARPNLEIPEVKEGFEQAFEQTVNWFNKTIPSEDISVVAVVATLSYLPKDLSCEAYANSERSADSVPRFEISTSSRHEALVEMTFLHQFDAEDSGGSTDTDEGVTIPPLASVAPTIRDLEVTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSD0</accession>
    <name>A0A8H5GSD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_006885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSD0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034777164" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="13">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="611"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5370368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="632" mass="68103" checksum="24CF39644916EBD2" modified="2022-01-19" version="1">MPRFPAALTFGVWFSVALGQYCSLPDVNPEEFAATNFDYLVVGAGPGGLTVASRLSEDPNVAVGVLEAGGVHMIDEVITVPGFSGQALGDPKYDWAYSSVPQRFANNRSIPSFRGRMLGGSSAINGMAWGRPGARELDAWDQINNGAGSWGFDAMLPYFLKTETIQTEYISFLPGLDNPELLASFHGQENGTDGAVKASLNTFIDEAVPPYVRAMNEFGVRTNQDPQSGNTTGVWNTLMALDRDHGVRSEAGMAYCFAYGRPNLKILTSAFVRKIVFSHGAKGYDAAGLVFSMNGSDSQFSVNATREVIVSGGSVNTPALLEHSGIGDPEILRAAGVEPLVDLPGVGANLQEHPYVPSVFQLLPSLVTFDVLKNETTMAEQKAIYDNNGTGLLAATNPTLAFFTSRQIFSENVTQSLLSTFDSDVQSGGVADTRFTALNKAQFAIQRRWLEEDVVVSAEMLHRGGDSELKDNNRYMELLTGLMQPVSRGYVHINSSDPTGPPIINPNYFAASYDRQMVTEFLRFHRVLAAESELEGVIVKQIAPTVNITSDEDLLNYARDTVSAGAHITGSAAMAPKELGGVVDSKLRVHGVGRLRVVDCSIFPMQLALHPQALVYAIGEKAADLIKAAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT50</accession>
    <name>A0A8H5GT50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="4">
        <location>
            <begin position="156"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3217"/>
            <end position="3240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5370617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="3319" mass="371482" checksum="CFC8D65664ECD469" modified="2022-01-19" version="1">MQQRYHAERKHLIQSLDALLHQLFCLSYYLSPSMFALLLRLSAQVMCRSPREMFPTLPLGGFLLVLLCFNGLSLYRHATHGAMEGGAIILDFVGLVIASFLYLFYFNRVLAWVLGLIIRLLYWGDSDSSIYLEIGTSFSHLFALSDSTCVLNTKGSIQFSILSGRILLKDVHYHSSNQTIKVVKAQIAWRYWIRRPTTEEEIGLSLGEDEKPTTRTSSCRIHLSLNGFEWLLYNRTAAYDQIMSQLRTKSSQHSPNIDRHATAPKLADSSAPTAPSLITSSLRFHTPGFLQNVISWIRRQLPNLDPKDLLPLGIEVVKGAIICGNSSTPNLLVAEFQRSDGTFGVIKSRSKYDLYKQMLTLHFKHASVQYVHNDDYCEPMGATGQTMERHIHQDLKSSATFSYGHYSGFSKLWAQSRLSKLVTGYFSLRKTRNHVDRRRRRKKSTEEDTPIGADFSTIEYAIERRILDTPLLQLCYYADVVGVVPTPQHPHVKSQSQVFPDIGNGDVGPEWGMDLVIFGGTLKYGPWADRQRSELQRAFFPPTYHNSEETPRLHPGDKRVWTALRVFVELRNDTTLVIPFREASKDWLWDGLTPGVTRSRKREHAFLHLTAGDKSSISYLMPMLAGPKGYEPILEVHLDTIAVTSSLNDIRLVSAESCRIHCELPSPLVWDAEREWKVSVSLRSPTLFLLRDHINMFTDLGKDWAAGPPSDYHRFVPMVYQVGIDMHHYQIQLYANDHNIIDKPLIKEENGMFFPHHELNQADYHLTALFTLFGMRCQSIVKIPSNVFRPDSTSVTFSVEIPNVSINLSLPRWNTNALHAPKEGNNLANIGSFSIDGSYLYYSEVHQDNVEQLKLAFTARNIAFKALGWSIRYFMILKDNYFGSFTHFSTLYEYLDKIKKGEPPGDPIDLKYREGKSNMMQVEMSVLIKGGLLILPAGLSGYEFGPGSRQAVGIGHCVLLSVPELQLHFRMHDYFMEMSLNIDPVSASVEKDYPEVVVYSRRESRSCFVIDGIDITANRLFGAPPRTLTYTCIWEIHLGATKIDCSSADAVYLSAAGKAFLFNFDDFLNAPAKDYSPPVLLDLTFLKLSLDTVDAVWRAGKANVVLSIPSGMKLESNDLGGQFHKRLFSLALPQLNMKLLLLQGLDKLIEAADLEADLFLDIFSSPAGWHEKAEAQAEFVSSEDISTGRVKRMLANDYQQGNFAMHRNGVFIPGISFPDPDAYSNKGTSRARTLSDQSLQSMASQSSKSGDESVSEAVRDARLATTRAMTPKPLMAVEDADENILDGDESDDGDLTERSESEWMGSGDYSDAEQPESDWRLYRNLIRHYISRYMRDAIEWDGALIELVKGSKLPGVPPYTQHVDVELQSVKSFACPQKNADTTVYRIVQRKGTAVFVTPLLPQAFAFLEADMDTAIPSAELFLDSTLMSHLNSLLDEKKAKEDVSHSVLDIRLEAIRLRMLQHVGLATNVLQSPPLEVGQPDVSDKRCSVLDVYVQNISIYGQLSSRASVSAHLTFANARSELFIIENELHTVHVQPPSLILSVHKFSVTSNKATADVACSCFEVNISHSLPETLSLTSLAIADQASELAVTVKKLMKFRVETPLKFFGTILQSSDNAAVIDPLSTIQPSFLVQTGIPQELRANTAFRFLFHLRDCLWAIREADWDAGILDNHVDMDDLEPLLMSRLSVLDPDVYSTSKLDSLHPLFPNLMLVGHTPTDRSRSISMSVSATIQAIRIVISDSENHSSSEMSLGTVVASLRSQDLDLIELSSNTRSKVMSQVSLRKKPLRPIRRLSVSLYLGDIKVTLHPYLINFSQQIIRVRRQYGHALRSLSSRMERKITADGPSSDMDLDIVVSIHQMCLQAVADNLIFQLGALGLQLSSTILTHSRHPVVGRSMNNSLIFQDISVQARSPSTSSISGNEQLAILVLSHCGINSLIREDESDPTIRIVFRLGGLCLKVPRSAIRTYRFFKEWQADFLPGVEATMQALLSELEKTPNEPITSSPMMKGQPSLQVHGLIKMVDVHLRVMRHTWVSWGAHSTTAHFATAETPLKGVQQTFGIHLSSQVFSITSDSKHSDDNRVRIELPSIFLSGHRDATSIHALALMHFLELKAKPSHWDTLLVVQQKFGQDFNDLAAFIQETRIKQLSPKDKPSRPREQPARYSIFLKMDGFRIGFEGLSSVLYLECPGISGKLDSSPEFSWSVMVADLTLSLAPRRTSEGSLMFDRQHRSAFVIIDFKVASKHRGLGANVSDSLDISIPKVHAVMQPSSIGELGDFVDHLQLEILERRERNAKELAAFKEKTQRILQTFEVKASELKPTESSSWWLNKYSLHFLIRSVGVAFPLDHDRKIGSHDSSVMRAFLFSIRSVQFSIDRGETGQAKMEDFSFQFVSRFRQSAPQDFAGESHETRNRLIYPRMQARLRSSGTSSSRQFFMEAHVSGFILDLDSSIPDHVFSLADVYRRGKDRVTKLSASTTRNAQESPALKPANLPSSNFFASLTFLSGKVCMHNTASSLSSRSRSSGVLDHPSATSLEGGAEVFSLPVVSVWAEYRALPARTTRGEGFDGSILMFKTTIHSSHNTLRPTLLPFLTEIVDLVETRLRTATSYHEPARAVPAKEANAFAGSDSEVNSPVSSLQISFSLRIDQSRLELTCHPDVNVVAALNWDSGGFVITASPGARNVTFTGAVDDWMLVTLRSLLPSEKTEYNPNRTISSISFVLDTEFLGGVRFSRLQDILCFKAVWLDRIPLFNTAEKHPTPVPTIYSTQLAKQEFTTLALIRIRQIHLDIDLGQSISSVALHLKNSTLRSKFTESRNELSISVEHVSIAARGNVAGYADVSHCKFQTIRLIHNARSDNSTNTRMLELRMTSGPLVVMIESDYQKLLHYRAEPLEVEILDDWPNVSDDDRPLKLSFTVNSPEVVAVATVGTIPKLLSYANKFSANLEAQREGASRESQTFRVSQSPKPDNPLSAVAEAMINSARTRLEEAGSGLSYSIRQHMSLKLDLLRLVIFPRTMADVEVAQFLGRGVRGRLERLVESQAGAAGKRDIRLSFSFMKISRYTQLGHVAMPPSSELSDGKQWLEDLLKDAAGADIVGLPSMMMHMISEESRETQQKTLHYDFDSKFVRHIDKEQDEDIYITLNVGLYSWLTVLRKTLTRELEQAKTAVDWRSAAGGYAKPVEVPTSDVPKSATMTRVSQDVPPPLVRSASALQTTFVMPEPTSRVTDPTSLKQDEPPLSAVSESSGLVYQPGTRQIERLTMRQLGDATPDVMHPFFMKKAGFSLEDSLPQYVHEYATTPLEEILEALLRLYSRQLQIGNSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUD9</accession>
    <name>A0A8H5GUD9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUD9"/>
    <dbReference type="OrthoDB" id="7873042at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5371174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="584" mass="64089" checksum="EAE4240C1C66AEC6" modified="2022-01-19" version="1">MTSSTNTFYCDCCGHPIPVSSPRVHCLSPACHDNYDLCAICALGERFIQNDGTHHPSHPTQIYKISGSIDNDRFRSPRRMGLGLHTDGASDTSVTSTATITYFDRAVGSPTSKSPGRTRSSGLTHHHRRSSGCNSVDSIGSIGSTGSFGSMGSIGSASSFGSMGTYSPATSNSTPSSTPEFKQDYTFGRRLSQLDAPLAAAFNSQYDSDGYAHLHLHDEILQNETQKGWTGWTWPSLFMPDMTPSLTFRQLLDAVFSSLDRQGTGYLTPEAYSRFLDDLGYDVENNVWKSYLRPIQGFVKEDVADQALRAIFDLFSIEYTLAARTLYDSDVAEIRAKSQSHKPRTHSLHLTTPDKLATPTGDPDVDASEPDITALSNQLQALLGSGRGTAFVTATQAGQGFAKKASETHTPTQSRSQSTSTTRQTRSRLSRIKSSSSSSILNPSPRHTRKLTTMPLLTREGFASLTCLNVLCDPDAERRCTRFHQVLGPLPREAFPAYPDLKSLKRVQDVFDHAERMRRISGHGTGTGTGRFVEYANSQMKERMQMHLGVELESSTFGQCHGRGWDVMGDDYNDGVTTLYTTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV51</accession>
    <name>A0A8H5GV51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV51"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38704" checksum="7EDAB864519EC4DD" modified="2022-01-19" version="1">MSRPSWAQDRSGLNDDYSYAFRHRPENSSQFVNDNYRSAYPTSQWDTRTIDSVTTNGIVGLYNHSSTNPTSQWDTFDSRTAPKDFTGRFSPDSTEGSTIDMEKSSSLNEVGNAENVKQFRQNTGNLWTKGSGGRCALRFFGCTFLVALYLFIAIFLTLVIYLRPPNASISQTPDVDLDGASLIDSGDGNGPTGFILPLRFNVSIWNPSFIPATVKTVDIKVLYPVNGTDFAIGNGTIHNQLVKSNARTNVSFPIDVNYSDDKDPNDSVLLDIADRCLLNNKGIGLNVKLNIKVNILGFPISAPTISFSLSFPCPFDTSKLQPFFLQLTDVAEETGLLDLLLQVVPNLAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVY1</accession>
    <name>A0A8H5GVY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVY1"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34870" checksum="FCC36BA80702F583" modified="2022-01-19" version="1">MRIDIMDTACQASENCHLPVDIILESCDGHRLGFHTTLLETQTDAFPLNGLTPPHPNEAVKMEESKDVLCLLAQFLHNTREPDLRKFHMAVLAGLFTAFDKWGIYRAHEMIRSAIRMTSEPLEALVLMYAKEEWKDDIEEVAHLLLKENDTSITKELVGRGEFKILVSWHLYTYAWFKRSEELKAHFDATVQDIAFGPGRFTAFGVYISGKPPTDIPPSCKWSEYKRQLHTSLKRLPMWTSNKDLKAAVKHHSSTAVPCISACSQLYDTNIMSGLEVKLHTLWPWLEDTLRDFPEPRWDSFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ18</accession>
    <name>A0A8H5GZ18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ18"/>
    <dbReference type="OrthoDB" id="10424008at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="215" mass="24454" checksum="CA10E1FB0972EBE6" modified="2022-01-19" version="1">MTSDKSHLIVRKTSRQGPGMERIEDEDLLTASRGMLRTTEFAKLRPSRRTPMQHKDFIDYTDIIQQLRNSYLRSALLSLITFPFALSSFHWLNSKATYGAIDLPEIPGQVEVTNLVLYKYVNPAVLSSSFAESIRFTITMLICLCISLLAGLSALSQTIWLSKEFHLARLSNRGDFGDKLRWRRLSIPVYRFLQILAALLLAGSACNALLDFFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H029</accession>
    <name>A0A8H5H029_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H029"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10779" checksum="33153CD627413952" modified="2022-01-19" version="1">MNSAFGDEKDEFAGEDPGPNASEKEQIEWKRCQNTLAARKSRKRRLEHRQMLENKVDNLMVQVERWKTKAQTLEQILRSHGVPFSFDEDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H095</accession>
    <name>A0A8H5H095_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H095"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="970" mass="105869" checksum="7B17B7E9D358D75A" modified="2022-01-19" version="1">MNQLRVAKPDKRGIIVFLPKPQRNIPEDDFNLETTVPDMATSSIAEQQASFDAAYSGYLQQLEAMYPIGNHPLSPTKRIYEDKSTGKCWELTSLRIRAWASALSRGGATLAVPPSSSHFNVDECIKVMPRAPTASEGPAAPSVPTLAPAPVSTGLFGGSVGLGEILAIGIMSNMLGPGVAGSVMASAFPNLLGGISTPPAPPTAATPTIPPPLGNTTNAPSLPPSPSVKLSVDVPLDIFCSHYKLIAAIEAGLGKLGYIPGDTNLPRTEASDWRDYAGIPPLVWPKVIKAHKQFIADAVEGKWNDFMPTVPELTGPNYTIWASKSKSWLQSQGIAYVLNTLKPGEIQIVGSTSPVPAPPAAPAGTTGGTTAAAATDDEGSDAGSGVPSPHFIAATSGSVADWEKDNDKAMGVIKLCVAQAIGAKIENITTARVMWDTLKNLYGTPGAAEIFQNFKRAMNVEIPRNAHPSAAIDLIKMYLTRITNAGANTEIPMYLQYMIVINKLPPDIYAYIIARITQDDVDDFEHEMLDSLRTHVVNTWEARSRKKPQSANATKITAIKRKGKPPVFEEQQQQRHKGGSSAWRGKGQGRGNWRGCGKHASEQTRQKQQAQSMGPIKLGHSHVIHAAKFFKETPTITVMEPSTKDVRKPFFSESVKPFDRFFSSVQNAFKTARNNGLKPTGELLKDLELAHMSHSEASTSLPRPSIISDGRSFMERYYWQNLVAPYPPGYTFSHTDSNPDHDDDHWFTIRDNKPVSDGWGAANWGTPQQEEAWNNFGWKHDKCMGTDDNAEMAEEDDRLSDSLISNVGSMNLEEFEREKEESTKRLRMWEAGLINMGDSDKENVDPNPKTLAERLQMVNDEMTQRWYSGEFDREYNDGLKDLDGDLDQMSTSNSSGWSQARSVTPLFEEISTSPHASNSGADSLLDLITPPLSSPDMDVISLGSDSEEEMISESWNDGGYYSADDEPGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1C9</accession>
    <name>A0A8H5H1C9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1C9"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="8">
        <location>
            <begin position="358"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5374882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="529" mass="58495" checksum="89046B6B6F065AD4" modified="2022-01-19" version="1">MTQWEVRMSNSRRVPYFYNAETKEAVWDPPAGLSKQEIKALPGAELLSGGGGASGQVKASHLLVKHSGSRRPASWKEANITRSKEEAIDILKGYQAEIGDSGEKFGELAKVHSDCSSHEKNGDLGWFGRGQMQKPFEDATFALEVGEISDIISIFALIATFSYWSLKPSTFRLASSPITNTNMATIASIEQEQNELKEAMEAATKGVPLPYADRLDKPNFGYGNIKVSKLLVHPIKNDRKWAIIDATKHVVITARDVAKMVLITPKVEVDEDSPYGGVLRISFPQDSGCDEFVIPLRPTEDILKAWSLINDIQLWDDLDLDGYICDTLPSMPSASGRSVSSILSAYFEKPVHLVYKGARPRQCDPTSQFPSLKATAVYQDGYPLLVLSEENVKAVEKELRRHVGTQGIEERWATDEIVVERFRPNIVIQGAGPFEEDYWEEICIGRDVSSALNHAGILLVSKCARCLLPNVSPETGIRDKAVPFKVLMKFRTGIIPDDKWKPCVGCNGVPRSEGMISVGDVVVVRKMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHK5</accession>
    <name>A0A8H5LHK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHK5"/>
    <dbReference type="OrthoDB" id="3027305at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="91" mass="10773" checksum="8F9EB00C06FC22DB" modified="2022-01-19" version="1">MRLLNTKTLKLEEFYADIPRYAILSHTWEKEEVTFQDIQNLQIARLKVGYAKVWNACARARNHDFEWIWIDSCCINKESSAELSEAINSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIR3</accession>
    <name>A0A8H5LIR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIR3"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5359030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="119" mass="13099" checksum="0457EC1005820F5C" modified="2022-01-19" version="1">MANASHDAHMNMSNISALFCRVLYDYEAQAHSELSFRRGDIIEIFTQQPSGWWDGLLGDERGWFPSNYVTIISEEEADIALNGSDSSNAESYNAGVDGASGQSRNSIVDMPHAILRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMM6</accession>
    <name>A0A8H5LMM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMM6"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034542752" description="Amidohydrolase-related domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="94"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5362753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="40406" checksum="FC8ECC82BD5C763E" modified="2022-01-19" version="1">MRLVPSSLALLTSISLITTPCLARRKWNDTGRGTIAFEESWGTPEIVGPLGGASPEALVQIRADIIDVHNQRLKKMDANGIDFMILSCVTPCIQGISSPSLAASTAKSLNNELASQISNNTLRFGALAALSMHDPVEAAQELNRTVKELGFLGALVNDYQQAGANNDTLIFYDTPQFDPFWKMVTDLDVPVYFHPRVNIPIILNLSYSHAPFLIGASQEFQATLSTHVLGLCTNGVFDRFPTLKVIVGHMGERVPSDLFRIDSRLDAQRSIGLPMKQTVRSYWHTNLYSTTSGDFDTSLLLYHKSQIGLDRIMFSVDYPFDTMEDASGWVNSLGGGKGGNGGKGGGNALTPEELLALKRKTAIKVFKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMV7</accession>
    <name>A0A8H5LMV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMV7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5363052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="79178" checksum="C33A4877F00B65E3" modified="2022-01-19" version="1">MRLLNTKTLRVQEFLTEIPLYAILSHTWEAEEVTFQDIQNIATLAATCNERPVTFDDVKAFLPTAQLKKGYTKVVQACVRARNSAFDWIWIDSCCINKESSAELSEAINSMYQYYEDAVVCYVYLFDVSGMLHPKNSESNFKKSKWFKRGWTLQELLAPEFISFFDKDWTKIGTRWSLRDLISLVTTIPIDVLEGRSIDEYSVAQKMSWAAHRKTTRPEDQAYCLMGIFGVSMSPIYGEGGDKAFMRLQQEIIRVSDDRSIFAWISEGQQWDRGLLARSPSEFRYSGRVQASNTGSTLGNNPSSYSFNNNGLHIHLPLKPSDFDSNVFLASLHCQTNDGSYMSVCLRRTTDGYYVRKSPSTVVLQPAPPPLDHVRELTVREKPTLRRSRFRLPGAGKNVVSLLPSAQHFVCSRLPPPSISTEFSVEFETPDADWTDLTYEFPSKSEAFTLGFTGWGYSLQIGDKRVDSIDMSSAADYMLGPLPNSCFVSVCLEMRGDEKQVFEIGYLSPEDSRSEGVATTVRPDLDFLVPSKFESYGSEEEHQSWGSFRCINVPQSDFLVLKYIEREKWWCSETEREGDSETERRDKRKGRGIEQGGPPTFYVAVGSHQSLPWTHITFNGKSTDDVRADIQSMKEDLYGQTSGTATINHSKLRVQIGPATVLNQATHQLRFDWVKDESDAVDEEEMKRSRKRIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQB0</accession>
    <name>A0A8H5LQB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQB0"/>
    <dbReference type="OrthoDB" id="10458487at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="22274" checksum="FD3BA9D52B287C67" modified="2022-01-19" version="1">MAEQTLTDAERKVLANIEQLVPPTPTMPGLKCGYEKAIDHLPLPFLPPQFFEGMYATMKPPVFHYGWHFKRADLAAAAADHNLLAKRVFAPGYQISATPQAAVDMDVHRTLRNIHLHLEDKGLNTPQLQYACVRVDSRIMISIATNYTGWLPDVQAVDALRDLLGREDEPVWDLDYESSGWQKCARNAPRVRYRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRK0</accession>
    <name>A0A8H5LRK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRK0"/>
    <dbReference type="OrthoDB" id="2851736at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65857" checksum="125FCA146F472C5A" modified="2022-01-19" version="1">MSNSQDCSQSVQNSDPCFYCLPYHSKSYTYPNDLIHVNQLVTEISSVDAELERVQNLLHSLQLRRAHLSSHLNTARSLISRLPNEVLEMVFSILCCEDNADELGEFCLNLHPGRHPAWVLSHVCSLWRNITMSLPKLWSRMEIQVEKVTDVSDEEIRCMEYFSKLFLQRSGDAHLDLILAFPSRNTENGYVEMDTSMLKPLIGLFYSQSQRWRYFSLSAYDSFFHPNPLLPWVESLPSIMSMKFDAIADTYDLRNGYRPLPIFKRLSAPSLRTLTLGGLASGWLVDAPRDIPAGPFECLQSLVISLDCFPGSALLRLASVSTTVTLANFDDCRDPIDFEHPDSTITCLASALCVNPIFTENTGFQLGEILRSISLPNVTRFSFGAGVSTASRSEWDPVQLVRFPTDQLLSLLHRCSADQITHLTINHYSFSDLDVDLVMILSRLPSLTHLEVDESPKDWESDPFQEHPFKPILTRSFFEALVIHTPISDHTLVPQLREASFSSQPFLNMTQNIGEVVANMLETRWRGGQSGLTRAKFSGFRSLLDMDEASAGSIIKRLREEGMSLELGSFLDLGRSLVTLVQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSE5</accession>
    <name>A0A8H5LSE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSE5"/>
    <dbReference type="OrthoDB" id="3068171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110491" checksum="A788A8C5AA5EA3FF" modified="2022-01-19" version="1">MERRILDSFDWTFISCRRPGSWDTSSNGLPLAFRDGSAMEEQNFRGKKSFWRFQKNLLSDQRIGSRNADFPFMEVDPAIIQIWFIVRVDDFIISSPHHHHCRPPHIPSSTCLSGSASSNQANAYSSYKQIFWRMGQFFDSIPPSLIPWIQKQQIFWVATAPLSKDGHVNLSPKCTRGMFYVFDEKTVWYEDMTGSGVETISHIRENGRVTILFTAFEGPPRIVRLFGTGIIHEFGSTEYNTLIPPETRQPGSRAVIMVDVHKVGTACGYSIPFFDFKSHRNQLHQWAVKKEVFDTSFDPLAPSESDNPSLTRNGAVQLTKLSHSTDFHASPSAGLLSEKGIRSYWLAHNAHSIDGIPGLATAPMCELAKSKEVWGFTSRRTYTSDQFASESMDSPVGNGSGTGTGGIIREKDRIHKSKTKGSLGDSSFWMGVGVGVGVMGVWMSVLGQDFSPPSIWQEPDLNTTLADRAKTAGDGLNEALLSFDESKAVFPVTPDIPVLPAYLFYELAKFDLLTNDTQYKSKLQGYYNVVKNVHVNFGGYTLLMNLSVQAYYAYRDDSFLQFAEDAWNYGLGFTITQDEVDAGKLNVKDITLPDGGQCNSSSIVGGTFFNSDVNDPYLAGLGTGAFFVLSSLLAEATSDPKYRTAATQSAQFIHTFLLDPNSNMIFDGFNADSCSSFNQDLFSYNTGLAIEGLAMLVSQTGDSTMGQWLKDILSASILKANWLSSHGIVQTPDDVQPQYLMLGMSAAYNYTTDSTIKDFVGKFITVQYNAIIHHATSDGSNLYGKDWTGPPLVQTSPRSQTAALSVLVNALALPDVASDSSDGGNGSGSSDGGGDGSTNATTSGTASKSNTAAIIGGAVGGAAFALLVLLGVWVLFRRRRARQTLKDHQRASIPYPVVTPYRDDGDFPMTERTRSENTGSNSAAYLTTVPLRTHIREGGSGNGYRGGKLGVANHTEAHHDEVASDTPPSLPPQNGNNMSTEELVRLLNQRLQGGESRSSGSEPDAPPAYHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSK6</accession>
    <name>A0A8H5LSK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSK6"/>
    <dbReference type="OrthoDB" id="3006091at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="14054" checksum="6F3934830C2B3194" modified="2022-01-19" version="1">MTSVTLQPSSLGTMNVYHDFPTDEKHQHSEQCQHGDTECAHGHAHAHSSSHRRCHASRLRRLLFPIIISLISVGAVLAFSCMYDMLGLFGSSTGEGGYDGLMKRQSAGNGSGSNGNNGDVFVDRKRECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU52</accession>
    <name>A0A8H5LU52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU52"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="20838" checksum="80AEA5A35FE0EFFB" modified="2022-01-19" version="1">MTSTSKSSETQSTKPTFYSYCSSLGGSTADVMQRILSFEADRTVNITINSFNTELSKEQGAKLFPAIGTLFPEGNNQLAKADELDQVRAVCENVSKYRSFFSDSPSSGAANGTGGGGDESSAVSQLEDRFFHMEVHLNKQAFLQQFQYGVFYAYMKLKEQEIRNLTWIAECIAQDARDRIQDFIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUJ4</accession>
    <name>A0A8H5LUJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CcmS related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUJ4"/>
    <dbReference type="OrthoDB" id="3171339at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058258">
        <property type="entry name" value="CcmS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26617">
        <property type="entry name" value="CcmS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CcmS related" evidence="2">
        <location>
            <begin position="487"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="671" mass="73491" checksum="017C9926E560717E" modified="2022-01-19" version="1">MAKTKKTKQKPEVHHETPTSPAPQASPHPGSPSQPDPAFQLQPESPQQFANNSDPGHDDSDNMMGMGVAEGGWGIGTQTSWPPTTAATGPWGFDKQVPAHGTTNTTTSAKKQASGAKQPQSGWGAWPEQKTPAWGNWGRGRESQAGRGGNDGWGGSMLEEDEEDEEIEEYEDDAWGTHTTAGAWDAQHTQHTAGGWGSTRTPATASAWTAQTPSAAAWGASAATPASAWKTATPKHASVPASGWRNWGEEAKRLSKTSVPQVPAGTRTSVNSQQRAQIHSGFPGFGGPTAQPVQVDQHSKQATDYLFQILSDQRQHAPPPQQDNRSKNKQKKEEKAGKHKHSQSEKPNVWGGWGGDGDDALGKGGDDHWGRGGDGDDGWGTASAWGGGGGGGWGDTGWGTIDEEEEYEEDDRRVRFSPSNAWSDSSRQTSLWAKEKNKDTPYSMPSRTLAHAYNGTSTSLHTSLPRSKISEYTNIEFHDSGGAALAPVEPALFGRARKAQDRLHWMFPADKDERVDSLINWIQTLHRFLQSRERGALFTNAAYRLPGENEPAFDWLTFDQLQATRDKIIQESVAMYDPSKQVIVFVFLPSPSGKSVAIWRRRINVPNNTRLMLQAEINQCLAALRSEEQYLVHVDEIPQSPKAKRISRGGALYSAAEVKKSKKKRKWWQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV98</accession>
    <name>A0A8H5LV98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV98"/>
    <dbReference type="OrthoDB" id="3238644at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="487" mass="53857" checksum="634E3F5B6D12B90F" modified="2022-01-19" version="1">MARRLKLSRQQLLEHLKILDSLPPPLPASLPPSPPASPPSFLGKRKQDVVEDSDRVKRHRSSQPLPPPLSLEPAEDGEVSESPQTPSPPPPSALPVRRPKHGTYPTSHHDSLYNKYHQEGRELKFSGDARFWSTFPRTAKDYRPLADPPPTDSPYHKNGIQIAKLELLDALIRFTFAMWNKEYSRGICYFESWDSSMAYIDWCKSKWVTDDSTSEAEKAFRGLIDMIRAFILIRKAVFYNRHHLKPQAAKMFESVKESIATAIDSSDPSNALLAAKSRTPPMLPSPANSIGATNSANSTPTGSGSTPSTSTDDPSSTPSVPVDAVPAMKIGPAIPRELLPPNKLSDNRPIPPHVVAAANSVSLSVKPQLIHTLHSHSQNFAQAAHLISSAENVLNLPIIARHFPRTFARMIYTSLSPNEEYEPDFEDEEGELFWPTQCASGDGLGWVCLLGQAMIKEYGKPYGYVGHAGIIKKPQAERQRPRPLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWI1</accession>
    <name>A0A8H5LWI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWI1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="90" mass="9808" checksum="15D5ED834692F9E4" modified="2022-01-19" version="1">MRLVQMFLKPAPTLLLMKVHSSGDVVVVNINFRLNVFGSPALNNGVQVVTGNYALADKIAALEWVQENIAIFGGDPKRVTVVGQSTERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX81</accession>
    <name>A0A8H5LX81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC45-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX81"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="79378" checksum="5DB1B6792E8FE0E6" modified="2022-01-19" version="1">MVFLAPPTETNPSYSEAYTKVLTTHRRSPLTSASSVIMLVAPDVDALCAARMLADLFKQDDVIYRIIPVSGISELERIRAELMTYAELHSLILLNMGGILDLSSPDWFGDFNPQVTVHVIDSTRPQNLSTLFGAGTNGERIVVWDDGGAAKLEEERKAWEALMYEPEPDSDEEDEDSDDDFSRHEDEEDEEEFEEIGTSSRKRRSLSDDRKGKRRRTDDERPRRMTQDERDIHLARLEKHYMAGTWHGQSASGTIYILATALERVDNDLLWLAILGLTYQYTSTRISRDKYDRYHSIYHDEVSRLNPPPPQGDKAQAALSPDDSSIRFSDELRFMLYRHWTLYDAMFHSSYVAGKLGIWKESGRKRLTGLLAKMGFSMLQTQQPFPHMDMALKRDLISQLEAVAPEYGLVELTYPSFMRCFGYRSQPLSACDAVEGISALLDVAGGVKMEVEVEGARNGGEWFGMGRLWEIPGLAAGAKWRKDEDTENIPPRGHPTSTVSKTKKSKTIEEDGDVEESKEVDWWVRNFWMAYDALSDIQLLQQSLRLAMSVHSAIIRQGTSILDKQEIKTMRSHRVVVMKQGPDLQLFSHPGVLSRLALWLVDALRDRLNNMNANTRMKRKSLPFVVACFNEPSNSFVVVGVMAAMDFGDVRKNEFGLAFLDAKERCNARTRHSSFDTSVLEINHDDLGVFLEALCEGPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXY2</accession>
    <name>A0A8H5LXY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXY2"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5373672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="16875" checksum="6B7A9EB2D1A023E1" modified="2022-01-19" version="1">MSKKLQPRRTLSLKTPTTMAIFGLWVINKAGGLVYQRNFADGLAQLTSNEYLVLAGTLHGIHAITSRLSPIPGSSSGAQVIEGETFKIVILLTVTGTKFVLLTSLAEPSADATLQKVYDVYADAVMKNPFHTPEMPIRNEGFEQRITALIGDGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY49</accession>
    <name>A0A8H5LY49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY49"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="152" mass="17133" checksum="080CFC0B972BF95C" modified="2022-01-19" version="1">MGSRGIRSRPKKIMLTFTLAMYALSTLDWAIDVRHVWTDLEVFIPGQLVDPTNMEMQASVNRVLLGDIVVCWRVSVVYKNDKWVFWTAVAWLVILVPLLLACNLTQIGVGFPNITHLHVLAGSQLYIDIFALSEKPIQSATIPHEIQSKDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYB4</accession>
    <name>A0A8H5LYB4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYB4"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRA" evidence="2">
        <location>
            <begin position="173"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="35404" checksum="D6FC1083FCCEA614" modified="2022-01-19" version="1">MPPDIVDKSHLSPYHLRAIVLDYLSHSGYTNTARAFLRDSTIRHLDMDGEEVAQVEPGPSHLSESTLKQTELRNQIRLELLSGRVDEATNLLNKYFPSVLSLEDANPTSTPPSHGMDYTASTSVHPAHLNLNLRIQAFIEACRTRPLHYPPSTHESTPDPQEVGTASEANTIDQQTNLLNCARKLYAYLKMLPSKGDMERYTKELETVTGLLAYKVPEDSSVSGYLEQWRREAVADQINGAILYHSNLPPISQLEFHTRYNSTAWSLLHELKVKPRPEASLPPTGVQKNPKSTKDTEGLEFCPPFDLQEFLDNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ18</accession>
    <name>A0A8H5LZ18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ18"/>
    <dbReference type="OrthoDB" id="4093673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="71" mass="7980" checksum="20C5808D4C95D2E4" modified="2022-01-19" version="1">MSLLRRASPILMTSIIGMASGVYIFRPLILEHIEWSRQNTRAKKSDPHHSDTKSGALEPSKNDTNKSKTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZA0</accession>
    <name>A0A8H5LZA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZA0"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034567541" description="Phosphoglycerate mutase-like protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60318" checksum="ED93C61A6BCC0B4C" modified="2022-01-19" version="1">MLLLTSCALAVTLARLGATASTFAGSTSTFQFPQPMPLSLRPILSSQTLNRSALQDQLQVAGDEAGSIATAPAVAKVEQAFPLVQPNTSDNKESSFNVIDHWGNLSPFKSVASFGLPNASAVIPAGYTLQQVQLLHRHGARYPTSGSGPADFATELHAAAQGVGFNATGPLEFLNIWTYKLGAEILTPFGREQLFNLGVGFRVKYGQLLKGFSDLPVWRTTSEERMVDSAYVAAIGQNLNITDAGLACISQQAFSVFRAILPDYHQLIEIEADGFNSTLAPYEICPNANNNISSFGSVQSQKWIQLYLAPAQERLSPFIEGFNLTIADIYNMQTLCPYETVALGYSVFCDLFTEEEWKGFEYSLDLAFWYSNGPGNPATSALGRGWVEELVSRLTQERITSFGSSVNETIVSNDVTFPLNQPIFVDASHDTVITAIITAMNFTSIAANGPLPTDHIPDNQTYIVTQLAPFGSNLVGQVLSKDGSTNPTHIRWILNDGVVPLTGINGCAEDPNGLCDLPTFIAGMKQRIQEIDFDFDCFANYTIPDPDTITDGQFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BUZ5</accession>
    <name>A0A8H5BUZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000352">
        <property type="protein sequence ID" value="KAF5329003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BUZ5"/>
    <dbReference type="OrthoDB" id="3172906at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="21543" checksum="5618F065F5B5F50D" modified="2022-01-19" version="1">MRGPRTPLHRIQHLPQHQDHQAYHPPLAVATSERLLVPARMTTETSVAFQSPSPVHQRQIASPDMTEAPVSSAPLPAPPKPSRLYTTIPLPPQVDPGVSIIPFLQSGSGSGLDIDLPVSRCSSDESTATVNDGGPSKAALANNGISLGMEYVTVWDVLVTIVESLRLPIPMIPGADSNGMRGGVEPGPGWITYQGAVGRVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4D9</accession>
    <name>A0A8H5C4D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4D9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="236" mass="24717" checksum="14C2AEE26A1A221F" modified="2022-01-19" version="1">MAHFTGLVGEAYMEGDQEGDQQKGKEKREEVEKWWEVGELEKIEAATSTKPKRRGGRTSLTSTTSQSQSPSSPYLSRTVDLLNSLDPLGPTASSSKVSRGTRGGGAVPIVASSMKLRERKKPGATTGTASTANSNSASVVASPNKPNASRETITASVSAISDVVEEPPASDTELSLSPSESESRNGKDEEDELIDVESSSHLDLSTPRAELGSGAGLRGAGRDGEGREDGGKKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C561</accession>
    <name>A0A8H5C561_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_016225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000244">
        <property type="protein sequence ID" value="KAF5335271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C561"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034592176" evidence="6">
        <location>
            <begin position="21"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="447"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5335271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="598" mass="64381" checksum="CF4EBEB5387125A8" modified="2022-01-19" version="1">MRNISQVAFLLFVSASVARAAIFRSPSELPKGVEYDYVIVGGGVAGSVLANRLTEDANATVLVLEAGGTYDDQLIPHIPFFTTRMPRMYKWNFTSVPQAGINGDSINYGRGFILGGSSAVNGMYYTRGSSEDFERLAAVTEDEGWNWDNIVPYFLKSEKFTPPADGHNTTGDFIPSAHNMGGSGRVAVSLPGFEQSLDNLVIQASQQLGGIFQFNEDQNSGNNLGIGWNTATIDISNRSSAAAAYLTPEDVARDNLHILVNARASRVLSVDGTTDIRSVEYAQDLDGPFFTVNATREVLITSGVFGTPAILLNSGIGSAAYLQGLGIQLVLDLPSVGKNFTDQPSISTAWLVNSTTTWDTFNRNQTNIDEALDQWANERSGPLVDTLGNQLGFFRVNDSVLEQFGPDPASGPNSPHLELLAANGLFSPNPPAEGNFMSISINLVSAESRGSFLLNDTDRSPFASPIIDPQYLSTKFDKVALREGIKTAFQFLTAPVFQDYVLGFSGDLLNGTLPITDDLIDQYVAENTATSNHPIGTCSMSPKGAQWGVVDPDFRVKGARGLRIVDASTFPYNPSAHPMSVMYAMAERAADLIKADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5H7</accession>
    <name>A0A8H5C5H7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5H7"/>
    <dbReference type="OrthoDB" id="3069657at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="947" mass="101102" checksum="6B5333C378EDFD10" modified="2022-01-19" version="1">MALDWQADKSRAYNHLQRIGIPTGKPKHRGHRHTQSLTQLSNLSPIPSLSSIATATSTTLNTPTSTSSISVFQPKEEDLTPTPSPKTSRVRTPTTPLSKGKPLGRSDSLKSIASLSTAGSSLIRRLSLKSSASRSEALKTPPPRAQLVKPQSVTAHTPMASTSTCTQRASSFDSERIGVRSGGTPNAYVDRDAGGAYNHHHSSRSSSKPKRRQHSESMPSTPLRNHSYSSTSTSASKPSSSRPTHKSTQPPAVPTPVRPPSRSEHLLRTTLLKDDFALANNPNSITANDNTRPTTPTSSSSSHRRSQSHSSSNRSTSTSRRDSELIASSFLFRTNVSSATLPPPSSPAIAKPTPRRSATSISTPTPARTTKPLFGFMVDSSDDGDDDSSQGSGPYTYTQQPQQRRNQHQPGIMHSPWDVDEYRQHRETRHTHAPAQRPDGYTHGRSQSYTQLPPAPRPPLTPHEQVLRARLERVLSAGNETVTSKGKGRELDWDGEEERFEDYIGNVGLADRGDGRRKRSSLPVTARDQEREREGSISGLFLGWLWRGGPAETEQSIEQESPQSYTQEGNPQLPTPLTPRESKDGYMSQTYSPYHSPGRSRSHTAPAPSSPSQSRFLANNYNNNPTLSQSQSPKLSSSPSIAAAAFVHLSPNANGNVNTTGTPRGTPKRHVFCLESVPSVGALRERAEEDEAAAAKANVNNDGDKGGNMITPPPTPPRKDKEFVPDGLGNGEGEATPKKVASRRGSSSSAMTAKTTTFGGAALGRSKSARTAPNTPMSKAGRVDLGLGRPAGLSRHGSSRDDICVLLNSPSMQIPKSPGRMISPTKASFGFSSPTGPTSAIDPTTSTVSPASADANASLSPASLSPVNSPVSSLLSNTSSFNARTASAQCRLMDGYVSFASIEGLGEPPASAHPSVGDGHSMLGDEDGDDKEREGGGKRFLGWILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6W7</accession>
    <name>A0A8H5C6W7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6W7"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034694915" evidence="1">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="26564" checksum="A3D40A251D10BBF3" modified="2022-01-19" version="1">MLPTTMAKSPFFLLLCLPSMAMAIDYDDNLWPSLPLLRKRASRNVPEQGFYDPRSNGGSMLTVVEGTFPPGQGEPINMIISGNSDEDVLNDREEDGGLRNYWLSLEFAGECLGQHSGSDQGANLGDDNGTKNETAVIRFNYGNPQLGTCQETVDGGNHFRYWVQDGSQANSGAIFMAASYEMPIASQHDIVSNGYNLARDYIVGNITQQTIPSVNLTNSTTYSGTTSFDGYTYQTDVLYVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9S5</accession>
    <name>A0A8H5C9S5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9S5"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="269"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="320" mass="35202" checksum="0E3207498339B38F" modified="2022-01-19" version="1">MPRSSSVPVRSTTARKTFKRHISLPAHFTNEPMFITFQNPALTANTAEALAGAMKPETHHRQELAVLEFTNWGNNMGFHTEDLLPVNENILVEFTASFKGQLAGGTVKAKLSAIKTWHLTLGFPWRGSELLRCTLTGIEHLAPASSHHPEHPPVTHDMMRSLHAAFSQSDKGIHKAASTGSKLGFLGQLCLGELFPRHSDPHLFEFKKHSRVLDAVELPPPICKHKYGSIDLFLPGTKTEGCKGDRAHITPFKGSLNAIKATHAHNKGLVCLYSAGYSNEYCEEVMAQFKAGKVQVLICTDAAGMGCNIPDIQVINRWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9T6</accession>
    <name>A0A8H5C9T6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose mutarotase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000220">
        <property type="protein sequence ID" value="KAF5336803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9T6"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15687" checksum="BCA84D3670495B15" modified="2022-01-19" version="1">MVLILAQLPSRLSAIPVYDITPIPTCHSTFPSQFQPFDLTTLSAPDGSITAKFVSFGATMTELWVKDRNGRARDVILGYDDNSKLLTDPAHPVFNPIVGRYANRIKNGSYLVPSCPQIRRHVGLSFRPTSHDRSGLILPNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA70</accession>
    <name>A0A8H5CA70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000206">
        <property type="protein sequence ID" value="KAF5337788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA70"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="343" mass="37241" checksum="1C35617C03E15FBC" modified="2022-01-19" version="1">MAALDYRLSGTTPTSPPSQIQTKILEKITPVPSFLSRYTPSYRFCSAFIIMGNERNLYQGLPTILSANGTGKSTLLNFITGVLQPVEGTISRHSALKLAKYSQHSSDQLPYDKSPIQYFQSLFAEKYPQKDVQAWRAQLGRFGLSGAHQTSVIRQLSDGLRNRVVFAQLAMDHPHILLLGPFSFSFRFVSSRFRIPFSGPQIPKYTRVPELAWGVNVNASVGVGLCVVSSSLSLSLSLRKLVSVLVLVLLLAVLIVWCGVMGTYGYDMVDDVSVGCQWSALVVVGTWSLSRHSLHLGAAIASGSFITVVVDVGVGGRWPLAFTGAAAIEKAKLFSKTAPKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEB8</accession>
    <name>A0A8H5CEB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Choline dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_014980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEB8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034962204" description="Choline dehydrogenase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="354"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5340174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56431" checksum="845FFB8CF5479902" modified="2022-01-19" version="1">MTRLRLKLFSFLSLSLLTLQLVSLDSLLVSARVASTNPNPNLPQCSDIRPQGLQDRPQYDYVVVGSGAGGGPLASRLAEEGFSVLVFDAGHDVNNLNTTIPLYFARASDDPQLDLNYTVSEYPEGFRFQKNDAWYPRALEDSISDLEGTSSEEGREGRLVFALDTVWRRIRIWGALPVASNFDGKEESLEDRVERVLVRKEVIVSAGVFQSPQLLMLSGIGNSSHLEEHAIEPVVHLPGVGNNLQDHDEIAMIFQTKGNFSFFNGCTFLSDPEEDPCLEYWKESGGKNVYSFSALDVITSTSPRGEDSSEAPSPPDILSYFGPFYFPGFVRGYPQLLANKSHNSITAIALKAHPSSLGTVRLSGSHPQDILQIHKNRFQDADRGYQDVVDLREALKRIRKLIRGSVLIGPYVEKEIAPGEDVESDEEIEEYIYRNVFGHHACCTNAIGPDDDDNAVLDGNFKVRGVNNLRVVDASSWPNVPGFFITTPIYMISEKAADVIIDEARRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFI8</accession>
    <name>A0A8H5CFI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000172">
        <property type="protein sequence ID" value="KAF5340820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFI8"/>
    <dbReference type="OrthoDB" id="2447764at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116296" checksum="E06114A297BEBB17" modified="2022-01-19" version="1">MDATCMYSGHNWCALQTQLVRTLDTLWTQPARTLDATCTHSGHSLHAPWTQLVCTLDATCAHPGCNLWALWTQPARTLDSTCGHSGHNLRAPWTQPVHTLDTTCTHSGRNLHTLWMHSGRNLHAPWTDALWTQPMHPLETTCAHPGGNLHALWTQPARTLDQPACTLDTTCAHPGCNLHALWTQRVRTLDATCAHSGHNLLRAPWKHSGHNLHATCMHPGHILHTPWTQPACTLDALWMHSGHTLDTTCAHSGRNLRAPWTQPVPTLYATCLHSGRNLHATWTNLHAHTLDATCTHSGHNLRTPWTQPARTLAATCVHPGLNLCAPWTQLVPLCSGRNLRTLRTLWMHSGCNLCAPWMQPAGTLDATCAHSGCTLDTTCTHPGRNLCALWKQPAHTLNATCAHSGRNLHTLWTQPARTLDTTCTHSGHNLRALWTQPARTLDATCTHSGPNLHALWMQPARTVDATCTHSGRNLHAPWTQLVRTLDAPWTQPVRTLDATYAHPGRNLRAPWTQPARTLDATCCANHGRTLEATCPHSGCNLHALWTQLARTLDATCMQSGCNLRALWTQLAHTLDATSAHSGHTLDTTCMHSGCTLDATCVHSGRNLHALWTQPVRTLDATCAHAERNLHAPWMQPAHTLDATCMHPGLNLCTPWMQPARTLDATCAHPGLNLHTLWTHSGRTLDTLWTQPARTLDATSAHPGHNLRPPCMQLACTLNATCAHSGRTLDATCAHPGRNLRALWTQPARNPDQPACTHSGHNLHTLWTQPAHTLDSTCTHSGRNLRAPWTQPVHTLDATCATLLWTQPARTLDATCAHSGRNLHALWTQLACTLDTLLHALWTQPVRTLDAPWTHSGRNLCAIWTQLAHTLDATCTHPPRNLRTLWTQPAHTLDTTCTHSGCNLHAPWMQPVHTLDTTCAHSRCNLCAMVLSAHRLHPDQEPATIKDGSLVYDVKEILDSHMHYNWKKKKLFLEYLVKWLGYSTVENTWEPAMELEKKCQELITKFHTKNPAAPRNMKTILSFVPREFYTSGPKKSQAWVYRISQASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG95</accession>
    <name>A0A8H5CG95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000174">
        <property type="protein sequence ID" value="KAF5340531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG95"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57358" checksum="1722404B780BB691" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFHIWADILISWLQATGLSSVLSTDRPDDAEVSLVSPLTEEDMATQTEAITAAQKKQADWDEKNDKAMGSIKLCLSPPVRQKTLGMTTAKEIWVFLKKTYGKPGVSAIYTDFKRATSITIPNDINPSAAIELIRMHFDRVSAYGIPTDGTSATSITKVANFLIVMFIISKLPPRYEYLINQYTQYTIEEVDNANLDVLQSEIVNIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQQQQQQRPSGSSSGTNGASGSNGNNKGKGKGKGKGKANFRRGGRAGKFEQAKRQGQAHLVNDDMSPMMHTVTVVNTPAAVDTRKPFFMETEKPFDAFFTGTKRAINLARDIGARPSGETVATLEDVVMSHTDPSSFTSLTPAPRSKRTLTERIYWNNLQSSTDGWGDAGNWNGWNGEYPETQTGSDADTACAQGEDANWNEDTLVNTSELGSVFGSTTTESGVKVSQDIRTPVPLIDRLAADPAAKMMECAMHLGERFQNHEHQEKPQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHA5</accession>
    <name>A0A8H5CHA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane fraction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_014730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHA5"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5341448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="36233" checksum="8DFA62BC6D446A42" modified="2022-01-19" version="1">MSTSSLSSTRTMNDSTNNPPSVPIRRPNNPNGTGAPPIWPIENSVDSETTPLTAKCARNSRADGICCKELKAEERTLIDPDVVRDVIIGLSDGLTVPFALTAGLSSLGTSRLVVLGGVAELIAGAISMGIGGFLASQAERDHYRYLKNQTAARVIRSCAGEMEREVEEVLGPVGVDEGTCRAVAKALREAGGEEDRSPEQRQRDEETGGDLRWSKDVGLTAFLLKFGQGLEEVPTSRLYISAFTIGLGYLIGGLIPLFPYFFIPQASTALIYSCVVTGAVLLVFGAIKAQVSVFFCSPVTGAYTSNSTLGVWKGIAWGAVSTLLVGGLAAGAAFAIVKALEGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJW2</accession>
    <name>A0A8H5CJW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJW2"/>
    <dbReference type="OrthoDB" id="3349471at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="3">
        <location>
            <begin position="389"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="4">
        <location>
            <begin position="551"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="775" mass="86692" checksum="625FB5BD5F2287FC" modified="2022-01-19" version="1">MERLHDEWMMKYWPFSSEKKRSRIPFMNLAGFSTWCAPAADFNRMVWGARIAGIFFLADDYIDSGKMLDRIPGFKTAATGTGPLHEEDQAEICHDIVFRAIKATSHPRTFDQLTKCTHEWWDSNIHEPFKNLDQYLAVRRVNIAMQSSNPLVFRKCGFNDDEQSAYFRYTLDINLTDEQINHPLMREAEGIVSDHVGLTNDFFSYLKEKMTNSDDTNIVRILMEHENLTYPEAKVVIEKKIRQKEQDFIGAGMAVLNDPSLGKIQKYISGLQICNTAWAVIWLGRRRCVPLKLDPSTFTTELWILNLSQSGRYNVGDIDGITFPSLSWAAEPTPEDEVVDDTEESLRRDKIFNVDAKDIPPPDFTIDDDEIFLSNPHAHIQQYVKLPERPKNVGIIGLEVSIPEQYIAVQAFENTDGVAPGTYSSSLGPVYFPDTSEDKVSIIFALLEKYNINPHAIGRVDTIADCRLPKSAQAKLERSFDEGAEFTNSKGITSAIFNARVLAGMEGYALVFGRNNGAAASGEVALLIGPDAPLVLEPIHGASITSGTPASLATYLKTLDKSLSAYERKVEKAAVKAEHLLATAVKLSDFDFSIFESPKPEYVQKAYSHMTYHDFVAHPPSSASRESIPASMDENSFQDWNLAKREINGTPIDQISKAQYTESVIPSQLLSTVLGNAYASSLYAGLASLLTNIPSYELFDKRISMFQYDGSGASTFFAIRVRGDTSHIQRRLDLKSRLAKMDLVTPSVYQNEARMEVGTAEVQLLRQRAITVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK33</accession>
    <name>A0A8H5CK33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK33"/>
    <dbReference type="OrthoDB" id="3054003at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="149" mass="16788" checksum="44DA1DB1404BE038" modified="2022-01-19" version="1">MWQSVKGKFKVTSQVYKDLVMKKLEGTKYTDSGDFSVHLNTLTKLQKVVNATGCGIDDAKMISIVLTSLPPSWILLIQLHQGKTVLNNITAALTKYWMWLQHTASTATDPTALTTVTKNRNDFLCNNCGVHRHTHLKCWATGEVRKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKU8</accession>
    <name>A0A8H5CKU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000137">
        <property type="protein sequence ID" value="KAF5343609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKU8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="10984" checksum="A5CE672A42AF071A" modified="2022-01-19" version="1">MAVTSLYRFEKMGVDALRTEKSRWVDRMGLGCVGDDMVTDATLSSAPHLYILFPSFHAILLQHALILILIDIPSLPQTPVSYDSSLLQGTAVNQVTPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLJ1</accession>
    <name>A0A8H5CLJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000153">
        <property type="protein sequence ID" value="KAF5342892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLJ1"/>
    <dbReference type="OrthoDB" id="1715602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5342892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24959" checksum="9A0061BED6686C24" modified="2022-01-19" version="1">MTMYLHPVIHKKKILCFKVTMRPDSPIPKKLQTKEKKHKSITTARANGEDPIESTIPSKKAKTADTGNVPVKPNRFDELPALQPPQADELGDELDRYLSMDVEATKDVLGWWYEKRKNFPTLYRMALDYLTIPATSADVERVFSRGRFLLPYVRNRLSADSTRALICLGQWSLMGLIHDEDVLAIAKLPEVEDPEQEAEDIEMPDGYEHQQIRNLVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP96</accession>
    <name>A0A8H5CP96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP96"/>
    <dbReference type="OrthoDB" id="2969033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="686" mass="76563" checksum="B5E4D4F98641081C" modified="2022-01-19" version="1">MATSNQCAVLPPVTMLHLCPKCNSSHLKPPTQAAGTGKDPRNYNRLYESCFNCDYFRWLGPPTPLEQVPESVQVQFALKESRRTASVTDPSQNGADSDCTDPNCRTAKGKAKKRSQRCPRQRCAACCRHMGPGCPIHHVNNWVSSTQGQDASGLTQPSATPTAVPSVASSSAVSSSQGNSEAVVQPRRFARPLSEGWGQAISMKRDHYEANRQQVESENTLRRTLANCLQVIIFAKANEEAQHFQVTTKHPKALVVVEQPLLLGVLEDPKSFIGVYIPKTNIWVSQEVTVPITVDGNCTSVLLRSYDLENDECKDLDTLVVSLFGSLRSSAKQASGPTTTSFSFRPTKSSSHLAIPTNVNRSFPLQYVIDMVPGLEKLVGLKGVASLKKAFEEEPTFQGCSFHKSTVYEARTVFCAARDLELLEKYKVAGRTEAGRWSELVKEVNSTSKVKGISIKKEPTLTEIPEPSYEVWTVRVNNYRLDCSTESLVTAWSAKNDNVDIVLSTDNAVRGRFYRVIYGWTKLEVNSLKLTSIEDGFNGRPEEEKLEEVQLAVKFAGYNQAPNWWMVCSPSRYATIWTEGSRLHGLEQAYQAFVYRAHQAGLAITVFEVVKTYLIDVKDSEIPLIAQPWIRGQAVDPKELEDDKTFSIFIHWCYEYFERQRVYVDFQVWSVVLANATLLVVKATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPR5</accession>
    <name>A0A8H5CPR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPR5"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="27628" checksum="C6675526948C09AC" modified="2022-01-19" version="1">MNHYFKVNHNRLTLSKTTMTRRILRSTSQRDRDNDNTNAPQTRAGQQKTSSKRKRDINENDALNASKPPLAKRKKHVKASTKAHDRDSDHDLFSIDLKGDEDGTVPIFDSCDVIREKIDDHLSETGVTKAQFLRNIARAAYPNNVPTIQTKQLNDFMRWAGATTGNSNRVFYAAYVYFEKKRISEGKSKSEHRKKMEKQWAHQGGMSRELCQYYWCRDGVELYEDEVGVRRSVKDRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSK8</accession>
    <name>A0A8H5CSK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSK8"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="99526" checksum="CA77AC62770F6D8E" modified="2022-01-19" version="1">MGAQQALGLSPSLSVSNSNEARNIYAEKVSTFTGEELETLMNDKYGVSGAVCHSTEEYLSSEHGKANAHAGLYQLFHIPNPKQPPTWWDAVDNRDADPRRPLFGLKVIDLTRIIAGATIGRELAELGASILRITSPNVTDISSINIDVGWGKWNAYLDLKKEEDREQLRGLMLESDVVIDGYRPHIMEKWGFGKDDVLRMCEGRKKGIVYARENCYGWNGPYSGRSGWQQISDGACGVSLKFGRAMGVDEPVTPVFPNSDCCTGISGATGILHALIQRAEKGGSYVVDVALNYYSQWLVRSCGTYPVDVWDDLWTRYGKPVFHHDDNMQITIPAFLKMLKDKAPELYDESYFEKRHSVPLGVDLRVVKPILGFPGNRVSLGYTVEPSYGASVEPLILPDWLLSPAPTPFTNAIWLRRLVAIFAVAVVLLFLTFAYLDVAFLSFHIPKLSFNFGSSSSCSPHAFSTGQWVYNSKTNKTSMTNSHEALEFAGLAGCASSREFYWHLASDKPEQWDRFPRVSSWDWVPNSQEKCSIAPFTPESFVRTLVNDGGWLVIGDSISEGHFFSLSCSLFPHVIATPDYSSGGWFDRAWPQNMYLNPESPLIRTLSLPAGFNISTTPLVTFRRVDLLWTQEELEKMHKELYPEKYPEMIVGRPPSGDNGNGPQPFKLFSDEKTWSLSPSEYVDIFTKSLPEANYGTLIIATAGHWTTTLFSGYRDESKESEGYGIEGVIQFFEKAMQGWADVVQKMLDAAETERPLALSKDSEGNTWRGSGTGRRKRRQVVIRAYLTGHEGCHEHRDPWKEIQPFEWSWYNWRYIDRFNEAFQNVVSKPKYPNIHYLPIERPARLRPDAHTTSDCLHIMAGVGVMEGWSKYIWHYITKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU41</accession>
    <name>A0A8H5CU41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU41"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="21011" checksum="D782D9C4F3061D02" modified="2022-01-19" version="1">MDMDMDGVVGLGAKPRLGLFGPVLGKENLRVGCLCGGMNFMKEHPEYVAEDKSMGYSSNNGDKKGGFNYELWGDAAVCSLASSLFLPKLKIQFLDEIAYEHNPTLIVFKRKRSGGVEGVRVIGGGVLITVVTLVCVYNDAINHLFQEASGPGAGLAKRQHVTCTAGLHLFRLHILVISLSSSLYPPLSTARSGLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWK7</accession>
    <name>A0A8H5CWK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWK7"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5349339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="74539" checksum="C18B4661EBD3F06B" modified="2022-01-19" version="1">MASYHKPAPSSIPSDYALLSRYAQHRQVEEEVIDSGDSGDETETETSLQRRRSRRSSRRSSHSNHQAQRHLSTLGLGIGSLVGDDIERVPAPRLTESTPLLNPDVPRIVENVDSEYTRDYPDGPVHNIPEDDDASSIGEPIYNETNTSTLAIFHSELRILTRYALPVYSTHLLEFSIVMASVLSIGHLSTTALAAISLGSMTANVTALSIIQGFISALDTMLPAAWTSRSPELVGLWSQRMAVVLAVALIPMLTVWWNAEVILLGLRQDPEVARLAGLYLRWMSLGLPAYAFNGVSRRYFQSQGLFTVPTRIIFIAAPVNAILNYILVWGPGKLAGIRLGFIGAPIATAIAFNLVSVLSLSYGVWIEKERERKYQLELANWEAEQQDEVGSETDNEQSPGQGVGSRRGGYGATSNDVERNASKKTQSQKQKCEKPKKKTAWYPLSFRSFTSLSQLVSLGLGGVGQTASEWWAWELVGLAAALLGPTILAAQSVLLVSASATFQAPFALGVGGSVRIGNLLGERHARRAKVAAYTCIVMGLGLSAIFSAMFVIFRNKWSYIFNDDPAVAKVVSQILPLVALFQVFDGNSAITAGILRARGKQILGALLNLSAYYVIGIPFGIWLAFRFDLGLAGLWIGLTVSLIYCSFFGTILCWRTDWEREVEKVKERLRGDMDGNGKGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CX23</accession>
    <name>A0A8H5CX23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CX23"/>
    <dbReference type="OrthoDB" id="10525674at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748921" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="16441" checksum="4DAA554A6824771A" modified="2022-01-19" version="1">MKLSGLAFILVLFTATSAAPLPGEIDLPEFLQRDAAAAPAKAFKRNIDTPEFLQRDAAAAPAKAFKRDIDTPEFLQRDASAAPAEAFKRDIDTPEFLQRDAAAAPAKAFKRNIDLPEFMQRDAAAAPAKAFKRDIDLPDALVEDTGAAPVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZF2</accession>
    <name>A0A8H5CZF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZF2"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="174"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="306"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5350807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64123" checksum="91BD2B4A3955D7A7" modified="2022-01-19" version="1">MPPACYTSRVGEKKQPSFFFFFFVHNHARVYVRRCPKGEQIPTPFRMVLISIPAQQRERPLDSHRLGSLRSLKVRQYAPRRAECVTSREHRRVSTLFQPSSCLTNFVAGKDSTAAFYGLHRQEVLLRPQYSRLKIGKIQGEKPRFKVPELGAISKVPYAEATWLSEGFKSPYYTKNHRQFHKAVRTFFEEVVKPEAIQCEDNGKRISQEVVDKICAMEILAMRMGPGKHLLGRKLMGGIVKPEEFDYFHEASYIINTEMSRFGTRGFADGFLNGGVIALPPVLKYASKELYEKVVPEVLSGKKYIALAITEAFAGSDVSGLQTTAVRDGDCWIVNGTKKWITNGTFSDYFTVGCKTDAGLTVLLVPRCQGVETKAIKTAYSSTAGTAYVTFDNVRVPVGNTLGKVNKGLSVILSNFNHERWAIICMATGAQRLIVEECMKWASQRMVFGKPLSSQAVIRSRLAQMISRAEASQNWLELITYQMNKMTLAEVSDKLAGQIALCKQFITKCGRETAEDATQVFGGRALTASGMGKAIENYHRTCGYDSILGGTEDIMRDLGVRQAMKKMPKDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0W7</accession>
    <name>A0A8H5D0W7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0W7"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5351546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31775" checksum="2CD454F6CAF10FEF" modified="2022-01-19" version="1">MDDEIDYEGLSPNAGLGVNMLAGALAGISEHAVMYPVDSIKTRMQVFATSPVAVYSGVGNAFTRIASTEGMRALWKGVSSVVLGAGPAHAVHFGTLEAVKELLGGNESGNQWLATSVAGASATTAADALMNPFDVIKQRMQVHKSEFSSIFTCARTVYRNEGLAAFYVSYPTTLAISIPFNAIQYTIYEHLKRAMNPRHEYSPSTHIIAGAGAGAVAAAVTTPLDVAKTMLQTRGTSHDPDIRNVRGMMDAFRVIWAKDGLKGFGRGLTPRVMTTMPSSALCWLSYEFFKVIIRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D264</accession>
    <name>A0A8H5D264_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D264"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5351361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="307" mass="33469" checksum="1B31C97B0B300DE1" modified="2022-01-19" version="1">MAGYPSPITSLGAQSIFGPDGELALARAAGKLGVPFICSTAYSRSMEAVARANEQFAPLNLTNRLKVAVSNLSLVGDLQPPIPVPTEINSTGQVLAPYFFQLYWALHNARPHDLERSYLPFGLDIGIEIGRTDPVFMKMHNRAAATTRYLTKEAKKENSPTTLKKPWLASAGKKGRKNNKSRLVFGESVIGGGEHREWEGPVVLKGIQSVADAETAVETFGGRGREGGLSLVIMEVPNLVPKSIRLDVLVELIRVTNNPQTFHQALPLIANLTRLAPESVLHNIMPIFTLMGSNIFHRDDSYSFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3J4</accession>
    <name>A0A8H5D3J4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3J4"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5351547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43449" checksum="15ED116C99EC5740" modified="2022-01-19" version="1">MSTTPSDNASGSSNPKVIPSLTRRAQDVTRGGTQKLKFVPVNPLRRQKEEVKNEPPPERLPPAASSSDRGRGRGRGDGSSRGRGRGAPRPPVEMTASGPFALGPAMVGNNARRPIPKSNFTPIPTPSNETRLGAGLSNTPAPSVKKEDKGKAKVMDDEETYSDQEDGVEIIDIEKIGDMDWMAPESLKKERQPVKIKKEDSGGTSGGDINLSNAVDLSESEDEEELEDIIDDFNQNVELETDPSLRQDKLYCFQFPSPFPTFKAANTAPAVSSSTKRVTFAEETKPESSQAATSAQTSDKDSTQPELVDGLIGKLEVYRSGLVKMRLTNGIVLDVTAATQPSFLQHAVEVNVEEKKMAVLGEVNKRFTVAPDVDTLLTAMQASDVAPMLLDGEENLIKMDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DAY3</accession>
    <name>A0A8H5DAY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DAY3"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="77063" checksum="9EFCFA27534F0A32" modified="2022-01-19" version="1">MPRPENRLWAYFYKGEKQNKSHFKAYCFGCIKNKAPAHIKNEPALDIKTMKNESWYKQDAGHVLGVKESMVAHILRGERPCNHASKEAKKEATIERNKLRKQGSKRGRDSEDGNTDQGEEDNTCVASSKKRQVVDLREYKQSTLDGKVFKDDVIPSAKQLSTSLLDAEYELVEEEVKQDVKDKDVVLTCDGVKDISKNSLTGVNISVETQPHLIDLYNSTPDKKDSLSMCESFEKMIDSAESIYGCRIIAMGMDNDAHQGQLILHDYLKVNPEANQTAEDATDLVGWFNNHGREIEQPLRIAALSHRDDVIAAQVGAEKNIRNASVLCSAATEHLDLINDNNFWRHLHSVVEDLEPICYTTNIFQSDRARPDVVLLAFVGLYLHFKNHTDKQLSLAMTKQLEKRWKSFDQHLLIAALILNPYKRLDHFGPDANANPFGLNSLISEISFGWLNDLGEERRKCLQSVSTAVTHYLAMTGPFQHWPEQRASWEAIHGNDPIIFWQQMTTDGRTADLAHFVLTLLSIVLNTASNERSFSDLKVKKTRLRNRLGTPKVKKMIKVGGRIRRHHYNAGLRTRCKPRKNHSEERLSTLLHVPQYAEALDGPDSDIDDDLHRRSPLVRSRREWRREFIKWAERARAEDSGDDDDNEPQASTVKVVDTLDNHPSHTMQESRFTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC73</accession>
    <name>A0A8H5FC73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC73"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5331451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="59" mass="6467" checksum="768313FAC150A760" modified="2022-01-19" version="1">MRFQAPTPDVLHWLGIDINGRGSYDTVVGSGMDVGRTYEWPGHLIPPDSRAEIDAKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDF5</accession>
    <name>A0A8H5FDF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000290">
        <property type="protein sequence ID" value="KAF5333055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="4">
        <location>
            <begin position="405"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="703"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5333055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="144602" checksum="CA151D744B9C0750" modified="2022-01-19" version="1">MSHVNIPKTFGALLVGGLWASCLSGGVSVQSLLYQKLYNSDPVSVRLLVFFVWFLDTFHTGLIWGSLWEYLIDDYGRPDRIDHVPWYELLDSRLKHPSDGNFGCLLPNCRSGIDVSKRPYLLSVYIDVRSLKLPTISRLNRSIMTVSKMNRYFAAPLYLFAFLRLVSATATTVEMLRLESFSEFRNQVRWLFTTGLALSSSVDIMITGSLFYLLHSSRQKGGHLDMVIDSLIIYTFETGSFTCAATIVSMICWIVKPTYLVFMGLHFVIGKLYANSLLVSLNMRKDLRSRQNTGTSITFPSIPLPEYAHSLEVPGLVLDTRRHRNHPYHCREHVTQSKTAPREVSLQIPISTLSTICLRPRRCFHIIRRRGSGWSQEKEKGTKRAPQTEATPSRSSSESDYAYTLLWDSALSGIFQRSSELVFVRSADRFDAVSARVILTQTYYNPTDVATSRAKYVFPVPASAAIAAFEFHTSDGRSVTAVSKEKGIAGDEYEQAVNENKPTVLLEMISDDLFTISVGSIPAKQTIKTKLVYAMTLMNNDLADEIRFFLPMYVAERYGPPQAGLQGADTSSSSSRTRLRIQVDIQTSGQIQNISSPSHSSSDDDLSIERYPTHLNRPSKRRMKVKFRSSTFLDRDFILLIRAKGLDAPRCFAEIRNDSDSLDKSRDRSRTRTRNGSQISSYTLAVQLTIVPKAVLPSIPSQEYIFLLDRSGSMDGIAIETAKRTLILLLRQLPSQGSFFNVFGFGSTVESYWSRSCSYVQGALEDITSSIRKIQADLGGTELFQALDAVFLSRHTNVPTAVFVLTDGQVTDISSITSLVHSKVSKSPLSSPLRVFTLGIGDGVSTDLCESVARAGNGVYIYAREPESILWKCARLFRAGRTPMVQNVTVDWGFPDTLLSNASRSPSVDFSDRYDQLRPDSIRLKPPPIQQAPPTVTTIHSGMRTDVYAILSLKTPHAPDYVVLRGQLDNDGSAFEHKVKIRGVELADSEHGAPLIHTLAAWKIIQSHQEGVAPLPQASGVGQGDPAAEGALRKAAIVKLGTTYQLASRFTSFVAVDDSLSPTSKRNNMFSARPQVGLYGAGDIDMDQEERRTKGDRTSRSSAAAQRPVDPTQDVHIPGSWPTVSEEDHINTRSDDDEAGTDYSIQSFTTLSSLVSRSDMSSDWESSESEPDLLGPTNEQARSPSPNFGISSTGSTTPGHTGKTRHDQAAASTPTLITDLISLQTWDGSFRLDSSFTSLAPSAAGVGFRDLGVTDDVWATAVAVALMEKTLADSNPELLDDLLVKAMDFLSNVSNLEEVLKRAKEVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFT4</accession>
    <name>A0A8H5FFT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFT4"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="191" mass="21025" checksum="C670D12210414222" modified="2022-01-19" version="1">MQAKWSNSDVDIMIDKLKNQKAQGNQSQSGWKPDTWTTVSKRIIAEGSQEGAKKNPKKCSDKYGTLKAQYKVVHYIRTKASGFGWDEQKQMVVATDEWWDRHLDEELIEWPSSPPASAPPPSSNSNLTVLASVSAAVPITTPARKRLRADSDPFTPPKSQKRGKGDQLSDIASGLHSIGQGLAANEPTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFV8</accession>
    <name>A0A8H5FFV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MmgE/PrpD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000237">
        <property type="protein sequence ID" value="KAF5335650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFV8"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5335650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="48475" checksum="875DBDE92FDD52BD" modified="2022-01-19" version="1">MATLALASWATNLTYTNLTPGVIDSAVKSVYNWAGCAIGGYTQDAPHIAQNTTQLSFSGPPTSSILGSNGSISSSFVDAQTAALVNGIAGHVDDYDDTHLATIIHPAGTVASALLAVAEWKSDPDAGVPITGQDFLTAFVAGVEAELKLGLSVWPEHYDVGWHDTSTTGSIGAAVAVGKLLGLDTTRMQHAIGVAATQVIGMQEFFGSMTKSFHVGRAAQSGMLAALLAENGFTSSLQGLEAQFGWLHVVSTRENASAYFEQLGSIWEIQQNTFKPFPCGIVMHPTIDACIQLHNETLDGGKSVSSIQAVNLLVNPEVLVLTGKTDPQTGLESKFSIYHAAAIGLLFGEGTPTEFTDDVVKNQTVVDLRNKVKVMTDDSIAEDQANVTITFDDGSTMEKHIEHAIGSLDNPLTDDELKKKFMDQVTRAIGGQRAEKANDAFTNIGNLSDVGKIRMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FG70</accession>
    <name>A0A8H5FG70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 76 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000239">
        <property type="protein sequence ID" value="KAF5335606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FG70"/>
    <dbReference type="OrthoDB" id="3068171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51746" checksum="CF5EFAF250884E37" modified="2022-01-19" version="1">MDFVFGYAAIHAYKAYNDEIFKRYAQDSWEYGMNYTLSNDQVAARHTPVKNFTLQVDCTGFKVTGGSFWASHKPQCCSSKWSFIWVISSLLAEVTANNTYLDAAIASSEFILNQLGNSNSLIKDSLNIGPTDTCQAGQDYPYNSGLTIEGLAILDALQPDPDRLQKLYNIISAATIADWHNKDGVIVSNAPSGYGHPQQGGDSHLIRAMNEVYHRTNDSNLQSYAEKYLSVQYNALLDFSTSEGTDIYGGQWTGPPSDQISGENQTVALSLLVNAISLTDAIQSPEPTFTTIPPGATLPASPPSSHSARTGAIIGGVIGGVILVILTGLCFLRLRRKNQRRLNAPSQYLPSFVVFPSSSQTTLGQSASSGYSRAQKGQNSNNRNQFASDRIIQPLDGKRGIREQTTLPASSADNVTQDTAPPATIVPITQPPLPSVQNRDNMTTEDLITLLNQRLQPGPHWEEEMPPEYPRTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHY5</accession>
    <name>A0A8H5FHY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000219">
        <property type="protein sequence ID" value="KAF5337436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHY5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="244" mass="27384" checksum="173A95C568219C8E" modified="2022-01-19" version="1">MLRVYKSFYELGVTELYRSIRITSFSGLAKLSKTRGLVHKEARIECPCLLVEFYMWISWAPPHFNIINIFQAIQNVKKLTLYAEGYHLPWTDVLLPQNITPLQYNNLLSIPDKGGYARHGQAAAAAILNGQISLPSLQSYRGPLLILQSFVKSTPALSSIMLDLLEDGEDSIPLLPKLSALEREESSLLGVNSPFLSLEVMISSSVQGNILRELIPKLPKRLQTLSRRVFYNTATPPIVISYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI04</accession>
    <name>A0A8H5FI04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EML-like second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI04"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="432" mass="47981" checksum="884D6A0085836B4E" modified="2022-01-19" version="1">MGYPDWPVNSVAFSPDGRHVVSGSDDNTVRIWDVQTGQQFGAPLEGHTKWVRSVAFSPDGRHVVSGSCDCTIRIWDIQTGQQVREHLEGHTGEVNSVAFSPDNRHVVLGSDDNTVRIWDMQTCQQLGKPLKGHAKLVSSVAFSLDGRHVVSGSDDMTIKIWDIQTCQQVGEPLEGHTNRIWSVAFSPDGRHVVSGSSDCTIRIWDIQTFQQFEEPQQLSNHTDAINSVAFSPDGRHVVSGSDDETTRIWDMQTCQQVGEPLKGHTASVQSVAFSPDGRHVVSGSGDCTIRIWDMQTCKQVGKPLDGYTVWVNSVAFSPDGRHVVSGSEDKTIRIWNIDPSNPNLIPALISQYNQENQSCSINAQGWLCTAEPEPKLILWIPTHLRDAFMNLRQVGTIPVDAKNFGVKVDWSKFVCGENWTSVWNDNIRLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJF6</accession>
    <name>A0A8H5FJF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJF6"/>
    <dbReference type="OrthoDB" id="2690066at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="44441" checksum="8FDB0EA29ADCE6D7" modified="2022-01-19" version="1">MPRPYGRAPPAQTTNAHAQHSRDSNALRASVLDVFVQLGALQKNSLITEWMFEEEGGNGGSSMDQRGRRDYGREEGRHEYGYDTESAEQRTIFEEPRMDDRVQSPTSESETRKGRSKFSSKITAVFRSRSKSKTRAEKASRNATNPPAQPPLPPLLPIPSRVGAVAEYETDEGYNSSSPSTQSGKRSKSRRRGISAFPIKSRPSESSEVSSSRPSTPSEFSSRPSHDRSHATSPTSDASVPFPVLSPVSSGSQTDKKKRFGRAPRGNLAVDGRVSEERDQDEGWEQFPPLTPGAFSPQVLNGTQPNVDRSKTPTQEVGNKQDGGTLLKRLSFAIPRTTFQKPVKRKNTKRPPSLLPIMDPPAFEKDGASKSLPPSPFILVAPELGAARICWSSGYSIHPLHPHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKH2</accession>
    <name>A0A8H5FKH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKH2"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="121" mass="13851" checksum="1F8807C84CBFAF3C" modified="2022-01-19" version="1">MKKTGTSSDENRRHKVSQLMDGKDWKKNRSLPPTNNSWPTCLIIAPSSVVGNWEGEFDTWGYFEIGCYIGPRQEREVVLKDFRYGRLDVGQLSPALIWRLEILSNSVTFIGHVSLSMKYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNQ7</accession>
    <name>A0A8H5FNQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055127">
        <property type="entry name" value="YEATS2_3HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22951">
        <property type="entry name" value="3HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="9">
        <location>
            <begin position="96"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="530"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5343526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1343" mass="145292" checksum="B4656A3CCA04F0B4" modified="2022-01-19" version="1">MRANCPGRVQESKAGLAIGKLRQHFSEEVADAAKDLVKKWKNELELKAKQAAWRINAKAATVSKISTPTATSSNRKTEVRSSKTDKPKINVTGDKIRDKCIELLYDALAVDSSVSTDLISQRAIAIESAVLNLFGTTADYKNNIRSLFVNLRDKNNPGLRESVVAGDIPADTLSKMTSSQVGSLNKRKNAMQTDSGQLDLEEAILVSEIDLEISLRERLAATLESRIKWASLLQDALNSETADVPQVVFKDAALNALTAIDANSDILFTRENFAPVAVAHSVNNAQKGKPTPKEKPLTRSQKSKFIYLRSSPSETQGSTQIYILRCPTCLRTAFTNLQGLYNHARISHSIGWGTHEECVKTCSVLKEEVEAQVGHEFELEAGIDIGSGSALLPGVKSLFQMAVEGTRDRVAGDACQEMETGEEKSVHLTKTLGLHGDSPALAQFLGKEAKRKEIKVRTEDENAEVDIHGLDEEQRPKRRWRRPNPHLYGSRSAESGAAVVPAIEDEDLKPLAELQNGSKMSEDLATPSIQSSRFRMACRIIITDSSLFVPPKQRAETAREHTHKWMLSVESASYSIDLTTVLTSMTVTSIPLPNMDPMDFIPIPALTATEPPYLVVGTTSEPFHAQIELVFNPGGSTHGGEAQKIILEHWVGLDMLGTSKSPVKGDEQMVDVELDKDTELRPAKTGYTPTSSRVHWETKKDGEVKVENDDRTDNLKTEPGVGDAGDVPNASNANGADSNDETKPDVTPSVPDPPSNKRGRSSNANAAVKPKLPYKLVANQEELNGLVMGRRKAIEWGRAKAIRDAYTERIKESQPRIPASPSTTSPGASDTAQIPLPSVNTELHINTSLIPLTVSDVFCWLEDEGHFFREPLPAPSGDQDTAAPTEDTSKESRWAQLLQDGKWCKVCGLGLWAHGILDIPDPASVTASQSGHGRRASTAASSSALSAITFPQPTEPGLYDMRGQPVSPQSFKCDIVPASLQMSKMPMVNVQRIFSKHINRRQQHLLAEAERERWEDADMDVDVDSVSATIAPTPAPYQPVTLPLPGQGRPLYPTPTTARHMSDSQKRLRNRLLVTITDPRLIEHYRTCVASLNLRAFQLPSETSPGPEYPLSSIAASSADVDSTLASYSLLAILTKSFVKYLVKEALEVSTRDKDLGLTWMHQNHIRDVGLALAGHPTTASRRSKAATTLGGAGATGGGEEVASRGRGRAKDKEKVKLQTTRVLTPMHVMAGVVSGYVKAGSMSLAPSSTASAALGLSSSAVGPSRYVPGATSSPQSISNILSGSFRPAHGPYSSTTISSLPSQERMATAVAVFGCLARLGIGVDGFDLDLGLGSSGSRRDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQF9</accession>
    <name>A0A8H5FQF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_008441</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQF9"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="245"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="593"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="770"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="718"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5345359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="829" mass="89205" checksum="A656E71327DF361C" modified="2022-01-19" version="1">MATSLPPFLSGQLDVLLIDNFDSFTWNLYQQFCLLGAKVTVIRNDAISPSLFPELKINHLVISPGPGHPQTDSGISREAIEYFQGKVPILGVCMGLECLVDLHGGQIAYAGEIMHGKVSRIRHDNRGCFKGVPQGIKSIRYHSLSASLSTIPASLAITSATEESGVIMGVRHRKYTLEAVQYHPESILSEGGDDLIRNFLSLRGGLWEENPESKVLDGSLPAFHIETPIKNGIAKAGSSKIPSVLEKIYNQRLADVTQAQKTPGTTAADLETLLSLNIAPPQIPFLSRLKENTEDHVALLAEIKRASPSKGPISVTTSPPSQALTYALAGANTISVLTEPKWFLGSLQDMLHARMAVAHLPNRPAILRKDFILSRYQIMESRIWGADTILLIVSMLPEALLRDLYAYSLELGMEPLVEVNNAKEMELALSLPAKVIGVNNRNLHDFQVDMATTSRLSEMTQGKDVFLCALSGISGPDDVKKYAAEGVGAILVGESLMRTKDTTSFIHRLLSIPEPPVQPQNWRSRSPLVKICGIRTEEEALAVTEAGADMLGLMFVEKSKRYIDSDTARSISKAIRGSRPSPSANTPLDNAPWFTSHATRLSSNLPRPLLVGVFQNQPLSTILNAVSYCELDAVQLHGSEPVGWAQQIPVPVIRAFHVGKGTGVDGITRGGYHNFILLDSLRDDGVSGGSGKVVDWEFAKQVVDAGEIVVDAGVYKTSSTESAEPSSTTEHVNGNGDAASPEDDPSVPSVNGHAKHGAVPNVALAVPSKYPLPVILAGGLTPENVADAIGLVRPWAVDVSGGVETEDGCAKDLDKVKSFISKAKNIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSB1</accession>
    <name>A0A8H5FSB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSB1"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5346918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="915" mass="99879" checksum="10E29FC5E1D92BD3" modified="2022-01-19" version="1">MATLSYVRIPSTAKRQDAKRQRTSLPSNPPNPPASLPTSFAILPQLLLSSSVPSEDAGYNPRRKRTKAVLLSNKDPLSIQTTTINFKRFVDRVGGLFWFQDTAEELMTWKKGWKPTTALLCVYAFICTFPQVLFVLPLVILACIMLSTAHIPRRRLPPPAVSFAPPSTTQDASPPPVEDSVDYQGNLQAIQNLMGLHADTHAAITPILSQLSLSSPVSTTVLTILALLIPSILFLSPFIPTRLIAFFGVALPVLSSNPHLSSLFLQLQHHVASSLRPNYLWTWSPSPTPTLTLPIPRPLAFFFPNRSLPLKPVPLTPRSFFPQHIPKVPVTQISFRFCPRPFITVNVSLPRSHMGASGLINRLKSLATLALSTNSLTDRIWNAELREVELWENERCDSQTAMRFGSVLANAGHDTNANATSTLRIGRKLSESLAFSSSPSTSPTVKKAKKAAKSNTSTPTSPTWTQTRTRNALLDTLAPLPPFALIPPLPASAMGDLVEEGSMEGVGDVETTLEKREREQKEYKENQNQKRPSLSMLSPKRTFSSSSSSHINPVPSSSSSANHINSISPEITQAIQTFKKGFSKSNLGTERAPWTRGRDGFGGINPLGVGLGSGSGSGSGNTSTSMGTNAMRRTMSGAHAHAHGEYEDPRDGKGASGNSGGGYEAGSEPAALGPGMISESTNKHVLTKTNSIIFPFPRLTQNLTRRSRFPQHTTHNTPYIALALTSNLTFSLAPGWKFIETEDWRVDYDAGAGASSVGAFKPDQVSSLLDDEGEDDDDEDDDEDGEGDSEEDGDGDGDDFGNGKSERGRWLDITFKAGVRKRTRPIGPSHGYYQVHQTRQTRQSQEEEEEEEGQWEQERKHQLEISFFIVFGVSVNVDVSFSFGRRGGTGVNDEDEDKGWMCGGDEGGFFSRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVI7</accession>
    <name>A0A8H5FVI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVI7"/>
    <dbReference type="OrthoDB" id="3236755at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="175"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5350308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="647" mass="71842" checksum="DD9E3D2058EEE950" modified="2022-01-19" version="1">MEPTHGTIELADDTSNGQDALAIPTEFLSILLPPLNCSVIDLVNFAIPTVDNPDTPVLNSSHFISATTQFNTPSNVKILRSQPVPSLAEIHALIPLVPGAIAQGQCCLMWPMESTLRLTPVPPQMNLPVWVLQYWETVHELWLHKKTWTMVQDWLEKKGWYASIYSTLSPVHWSQHLPNESGSTLDLVKFLSDSWLSDVQVTQMVAHLHSQKMDDQIWLMNNYWSNKLVVGYCKQERVLMKTGDALRGGSIQALAFPVFIRLGASAPELPSVEAPGNHWVAVVVDIAGQSIMYGDSLNHPAPNKLISAIRWWLSDWGTLSNDFGINDLPCGKQTDSESCGLYAINTLASYVTPIEISPFDKSFTPHRVHYGTFQKLVKYFNDIVSQCFYSQKRYRVVLILLKDPDLKLPVQQAIIPTTAPTTSQNTTIHPFFAPRTTASRKSSTKRKKEGMVNIRVKIRMIAENDERSDDDDADDDGSGDEDSGDDSEGNAPGKEILLLPAMERSGSAPQKAILNKLLQRCRYSNNPLTRSQYKCVGEGCNKVHANQNLQRALKHAIKCPSLPADLKVEVERIMVDKVPSSMVEKIQSTQTHAPIANAPITKNGTLDGHVQLGKKDRLRKRKAVLDLGVTKLFCVGNFAGLTADLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXT4</accession>
    <name>A0A8H5FXT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXT4"/>
    <dbReference type="OrthoDB" id="3265539at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="290" mass="33051" checksum="AB36180490084D35" modified="2022-01-19" version="1">MSDDSSSTPRFAKLNDSNYAAWSMRMEAELIRKELWNDVVEVMIDQVDDKGKPRKLEDIEADSEQRLNARSTTKMAQARAEMILRVEPGQLSHMRSKDPLVVWEDLKAVHCARGFAAFLSLKRKFLTMKKEKGQKMSAWIGEVKSQAFEMQEAGLKVPDLDIILGLTMGLPPSYDSLIINFDDTPPHELTLDHVTTRLLAEETRQLSRDSPTPQTTTTTNPKDLQYNVALGVNKASLPVEQITCWFCDEKGHYKENCEKRKKWLESRKGSGRAMMVVEAEDEAEDDDYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXV5</accession>
    <name>A0A8H5FXV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXV5"/>
    <dbReference type="OrthoDB" id="2861608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="697" mass="77727" checksum="1FAD8297A58D06A1" modified="2022-01-19" version="1">MSSANSTETLEIMIQPYRKPPACDYCKARRVLCHPQPFGRSCPRCLEKGVHCTTTPTVRRKRRQQREITAAKKVVTTREGDYSTKDDTHDTTWDKATSQSQELVTAGVLTTLSAGLPYAQTYVLANYAAFNDEYRRPIADTPVSSRPQIELPKRLMQDLFNAFVHTPYYNHPIVPYDNLRSRLVECGWQLSSLSPPECVLLYCIFAVTSLVSIDPLIIGLEPLSSEFTSILTTPQPVKRIKLDLRDIGRRRERVGLCHQLRAEALRQAQIEGIALWVSPESAASCYVLDALLDSEHDSPYSYGAAFSWQARTLAESWYRQVQPYSNIESMVRSIKWACFLMADGISALHSGRSVAFSARDEHLICGHKQLPLEKLASSLSQGCDCMQFYDCFLSIMFHITSGAREVYENISGPCARGRRFDFQAVKCYFTYLRLLYEVCDAHKTQGHLLSHQVQSQSWYILTTVRLVSVGWTNLTLHFYKTIKSMLEEGVTDLYDAALDHSFFVTGVDCYGRGGRLAPAQLAPIFVDARVLTCKAAIDFSEMIEDIYSISRLAQLKIVGGHLKGWVQFTVDVTDAGVMSASEGIQVLERLRDALKIAGFAWTDYTGLAEDIDSHVAALRASPATAQDSVHNNLGRHLNIHHPSPNPNPNLPPAGGPLVEAPETGVSQHAPSVYSGYTCGPLGFEILGVNSDLWTYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYG9</accession>
    <name>A0A8H5FYG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYG9"/>
    <dbReference type="OrthoDB" id="3262817at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="428" mass="47026" checksum="59F0EE1F472AFB17" modified="2022-01-19" version="1">MHLIASCRPAPSTLEDKPLIICQRGEKRKFLRREEDYNDMIRVVRRKFDIPEHQRPILETRSFDVCRGRNIEVDEDVYSIMISSLEEIEVVTLDSPVAADTVGAPHAESSATGTGHASSSRMTANGYGNQASDETNPTRRDKGKGRESEAERVDSNMNVGSGTSGQSRQSQGSSSASMTSPQSNDDILASLERIDNIGASQDLEDEPMTVTSSMHQGTTSSVWPPFDLRNPPLASLARSAPVGDEGSGTLLSDAQEAPALPSNLQDDEWEHVQVEQSGEPTSYHEHEENRNATAGPSNSQIPVHDDENSLGIKFNEKGYTDDGRLQIFIAGPTGETKLFILKQKHRTGELITNHTLSLIHVSSSRFLLHSSYLELLIQFEDDEATVQYYATCNKEDTVGQSGIRPLARLRLRVYGDGLENNETGVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYI3</accession>
    <name>A0A8H5FYI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYI3"/>
    <dbReference type="OrthoDB" id="3112770at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="322" mass="36854" checksum="3E0A5E03C5DA0682" modified="2022-01-19" version="1">MVFLVFHDWVVRPVSARVKRDAWVYVLSFRNIKACKIGCTRHTLRRRLQEWRCKDKSKGFKLVYSVWVSKERMFGIKHEAHQQVLKYTHKSNGACLNCSSKHQEEFVFIAAFGLRDACDAIDMAKELSVTNQFTTVMAVVSNYSLALDIKPKIAWTENQEKPPATLLDPLVLTTRSITDKYCGLLSVLDKICNEEEAEELGIEESMVWYPPDPAPAPQLPIPALSHVKRRKVRQEKIMVSKPTPPSLTIKDHLERLMDKLSMWQLMGDLDPPGTPKARKKGELDWMQLFCHDIIEPQTLFTSPVENEEKEAAKDDASADIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8F2</accession>
    <name>A0A8H5G8F2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8F2"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31604" checksum="5E0A71CFD3375575" modified="2022-01-19" version="1">MQTCQQVGKPLQGHTHLVHSVAFSIDGRHVVSGSYDKTIRIWDIQTNKQVGEPLRGHTEGVLSVAFSPDGRHIVSGSQDKTIRIWDMQTSQQAGRPLEHHTDWVWSVAFSPDGRHVVSASCDKTIRICDMQIFWKATLMKSILWPSHQVADMWCQDLMTELSEYGIFGVPLKGHTGRVQLVAFSPDGRHIVSGSHDSTIRIWDIQTWQQVGVPLEGHTNWLHLVAFSPDGRYMVSGYGDRSIRIWDMRTYQQVGEPLQGHRLGAVSGLLTKWLTCGVRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA34</accession>
    <name>A0A8H5GA34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA34"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="71" mass="8107" checksum="8895DF0FB4A15935" modified="2022-01-19" version="1">MMPVFTSFTFGMKCSSIAHMAYVRDRVSEGDTQEAKLCFSQFFYPTKRNSLNGPPVLRTHATLQLSHYISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAD9</accession>
    <name>A0A8H5GAD9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAD9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="36088" checksum="40B8FCDF52158358" modified="2022-01-19" version="1">MSKPIALVTGGTGLLGSHVISKLLADGKYVVRAAARSASKLKAIFPNAGSSLQVVEIPGLTSDFTDALKGVSAIVHVASPGFLKEETGEEIFNGAYEGSIHIVQQAIKLGVKKIVVTGTVASLFDTSFSKAFGATAVNEKDFGPVELKDIDKNDPNTMVIYSAAKTIADKKIWEIAHQHPDVDVTVLLPPAIYGPLVPNFPVASRSSLSTDGYVYDLISQGLDTWPGLPIADMVDVRDIARAHAVALDFPPLSGRDKRFIISSGKYSWKKVADLIRKERPELASRLPREDLEAPAQTTAPVDVSFTEDVLGFKDYIAWEETFLAAIDSVLVLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAE8</accession>
    <name>A0A8H5GAE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAE8"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="117"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5361166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="766" mass="85230" checksum="969D986C24AA55BD" modified="2022-01-19" version="1">MIVAASDMTENTEQVTNNTEQRGFIGDPPSAFGLATQPGPGINILQGASGFTVQHSTINAVGRDQVTNVQNINNYYQGTTDSDIGLLRERLNPILKPARKTDYCLVNTRVQILKDLCAWAVNPDIKLIWISGTAGTGKSAIAVTLAEKYREMQPQVTLAVTYHCVRGQETSNIARIVPTICYFLALTSPAYKAALVQKFWKDPSLNADLSPPMQIRAFLSFFQSDLNQGQAQIKPVIIVDGLDEMGNSDERYALLKEFESLFKEVPWFKLVITSRPQIKSEISDIWRASNQFQSVDLNNQYNADADIQAFFIYHLDRINAKWGAADHIEELVAKADGLFIWATTALKYLEEGVDKNYNLKTLLRSHNNNSKHGQYASLYALYTAVLEEHFTTDENALGYLKAIITYNGQIVQELCKEDLSPTEYVTVMEFSPDGHHLVAGREDGLGEIWNVLTGMQTEMQSLTSVSCIKYSPDGTMIATGSQTAVILWNADTGSQAHLPFTGHTDSVTHLAFSSDGKYIASSSLDQTIRIWDILTGIAIGLPLRGNYSSIAYSPDGTYLISANNFNIEMWNLNSKKKEIMITNDTVFSVAYTPDGKFILSASETNIFKWDAQTRQKIAKVDIPIVTDQWYSWYNKIAFSSNQRYVAIANGTSITKLEVSMDNSASVHPAKHVQASKLIGIVSVTYSADGKYIATASSDDRVRTWDVSTGQQIGKLILWIHPSLQRAFQDKRQVLTIPPDAENHSIELDWGNFAYGTSWTDAWSDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAW3</accession>
    <name>A0A8H5GAW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAW3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="39033" checksum="450EBAB99CA1482F" modified="2022-01-19" version="1">MFRSPWSSSKLDAPVSTSEIKKHNQFVVVGTVGNYRTIPKEIFDALVALDRPTAPVPVPRKQARHKDKDKGKGRNRHRQRRTATMTNVTHIQPIILLAPNVFGKVSPRMQLRSKHDPHPQLKPKHPPSSLRWSHVYAGEDVDVEKDVAMDVDVDMERVEIGTCDQHQVKMRAKRNELLKESKEQTLQLQTKEANRLRRLQIEKVQKDMQKRVREQANCQATRSSKGSHGQRQTVPANLNLNHLLERGKASIPRSRASTTPPPPSPSPQTALGRPICTQTHKKRKAENVPTPLPPPQPQSSKFDGQPQLKKSKILVEAGEVEELKEWVILDWMRNNPAMDDVGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GBA3</accession>
    <name>A0A8H5GBA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GBA3"/>
    <dbReference type="OrthoDB" id="2920504at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034252124" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18306" checksum="89EDDED613C34EA4" modified="2022-01-19" version="1">MSAMFSTSFFTLAALAATAIVQATPLTTRQANTCTPNAQGSGVSIVSLAHSGLELGSSAPASAGLAAPDFHIQQDGQAMPSFAVRDVTDNNLAITFVTAQDLELKTASNSGNDPNQLWEITCDTCLTPGAPVTPGTVVGNNCRVRVHGNDIVCVTIGQSAGAPVTVGACNGGAAQEFKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH62</accession>
    <name>A0A8H5GH62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH62"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5364739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56620" checksum="B8395C77BD2A5757" modified="2022-01-19" version="1">MTERRSASADPKLRCANRPHVFHPASNQDACYIPENGDDPWVPCKAQPCLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRNRSGQGTSTPTNQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNNSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLAQFNNYLRMNKGRYPTEESQVSLFLSFFTGEKGGDWATQRLTERDADEEDEELTDTPDQRRWITLKEIRDRFKRDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWKNFDQYQERAVELHLEWLKERERQGRWKTTSTSKNSPGPSQGRTVASVNVLMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFLRTSSQNTSRTFPSRTIRTTETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHC4</accession>
    <name>A0A8H5GHC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHC4"/>
    <dbReference type="OrthoDB" id="3226582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="38003" checksum="59B27A89AB2335C3" modified="2022-01-19" version="1">MSSSDPAELRLDLKLYLAQSMLESVVYGCYMVTFGMAMYVMTQRKGANAASRWDFWALVLLFLIATLVTLTDLIANASILYNTFGLGGLRPDMTKAQIHHFNISMHRDGICVRKIRRCYVVWNSSFKIVAVPIFISIVNNAVGFSAVVMLIDVFVGPLSEDTANPDTALSAFNAANKMLEAFFAVNVFSNVLLTGLIAGKIWWILRALQKMTAEAEYTIANAPMVRIRERYRSTIAIIVESGLLYPVSVIVFEIILQAVPLAPSLYPLMTTLAGMAPTLIITRVQLGVSVNTLNESANVLHLTGLNREEERSTGLTSSIAYRSNNSRQFVEKDEENSIDIVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI74</accession>
    <name>A0A8H5GI74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_005349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI74"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034471797" description="Hydrophobin" evidence="7">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="15682" checksum="5673F1FC48CAE7B6" modified="2022-01-19" version="1">MKFSSAFILAVASVATTVSAAPHETNGERLARGLPPMAPVRRSGTPAYAAKRTSPSGTPSQCNTGSTLCCDRTSTAGLESILLGLLGILGLDPNTSVGVTCSPLSVIGVGGNSWNVVLTQRSPFNVFSTQQPVCCENNNFNGVIAIGCSPINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI77</accession>
    <name>A0A8H5GI77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI77"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034286278" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="116"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="566" mass="61095" checksum="74C2DB10A10EA1CC" modified="2022-01-19" version="1">MKAVWWVVLFASGVLSEPRCRCLHGDSCWPTEDDFAQLQSQISQPLIHPVPPESACYPESNSSGNCTDVQTNTFTGTWRSDQAGAMQATNFETFISSNGTIEACYLNTALGFPCEQGSIPTIGVDARTVKDVQAAVKFAADRDLRLVVHNTGHDYLGRSAARGGFMLWTHRMKNITASPSFVPEGAPENETYYALTLEAGVQWHEAYDAAHVNGRLIVGGIAPGGSVGAAGGWIQGGGHGIFSPQHGLGVDNVVELTIVTASGEHLKANSYLNSDLFWAVRGGGGGTYGVVTSVTYRTHDISPFTATLVLCSPSSSAVRKDILTEYLKLWPGLSDAGWGAYLGMSTAANFSVTFVAPNVSLADTNATLAPFLDAVRTAQEDAVIQIIPFDDFQTFYQAFFGTPDTEDGLNTELVTRLIPRETFVDDPEHLIDVMMSLDPLLLFHVAGGKVSQIDPDSAGVNPAWRNATALMYSAAFWPEGVTVDEYRVIQQKLKDNLAVLESLAPGGGTYLNEASMYEPNPQHTFFGDHYERLKVIKDTYDPTGLFIVASGVGSEDWDSSLNCMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK18</accession>
    <name>A0A8H5GK18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK18"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="551" mass="59713" checksum="E5B8880F29B12DBA" modified="2022-01-19" version="1">MFGESESESPRVPSPWDSLSPSPSPSPPPPSHQILPRLPPESDLGNVEYKLQLLSPSTSRFTRLVTQLKWRLLEGGGQAYYELGVSDSGLLVGLSRDDLETSLETLEMMAGEIGASVIVVKEVEVPGRMAEIARRQEDYRKRASRNSSEGDFHFGSADSATSITTTSTSTTETETDETETETGTEQEESASASPSLKPANASDTTDLFVMDPDTDSELSIANAGTFVSLEISSVFKPRPFRTRVQLSPLNPHSHTRRRDAKKEKWKEKEAKQMKWREKNRDKESNTHSSTENEEDSSWKSTNRRMARDRRREEKRKALVAAANKSLAAREVENDAHNSVTTVSSTITSTVTSTSSPGPVDSVAVPTISLTTPTSAETPVTATLSTSTTVTTATTTSLLPEESPFLLTLSDLSLSDGQEAEPEPDDDADDTDIFPTPSIPHKHFVMSMSMTSQSTSTTPLSASEGFLTGTEESASYNDPHGSVNVHRAGINGTGTLQVPVPVPGVKDVNGEGDDDVDPNADARYIVEALVVRKMSLEEAFLDFGGFSVMADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK61</accession>
    <name>A0A8H5GK61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK61"/>
    <dbReference type="OrthoDB" id="3026661at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51339" checksum="74D3F22F71C27A4F" modified="2022-01-19" version="1">MSFLHPPACSSHLTLLPRSTTARCMKFFLRSMASEAVTSEATTSWKNKPLTRCVRVKNLPPTFTVTKLLRLKGMSRPIESVYRLPDHNEVEIHYLQPCGATRAVRAASEGNLVIDGQELEVRLCEPQRFPVEIVAGIVLKSASRVLWLRPPEQFKTVMALEEVMKRFGEVEDIWIDESGAKAKVTFSRIGMAMEAWKSLRSDEAWADSNVTFHIEHLQIFPREDNSTTAGQHRTVYLSHLPLDLDPHQLMKSVEDMIVWRHSEPILSFSMCNNTAFFHFKDSVSAQIFYDAYEPLGGIQKGWSHQDGPPAVSQLTAANLGASRQLSMIGLDVTRIDSRRLRWDFSEFGGVVRAHVDKRNCTALITFADILHACKAIDHIHENPSDFSLYKGAKIMFWHRERPKVGQTTRSLFYLRPMRIGGPLPATESEIVEDPIPLAISSSEDRELDELVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKM9</accession>
    <name>A0A8H5GKM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKM9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="235" mass="25096" checksum="1A944ECE3D4C2DAA" modified="2022-01-19" version="1">MSSASRAKSSRQARSSWSSSPSSSPSLSSSQSPSSSSSSSQASGPFPSTPTSPVVTVPEPPVYNATELSYPADASTLTLPAPENPDTYHDGIQDSAWDLNYSYSHEQVQFDTFPNMTYPAYEAGPALEGASSNFTTFDETTGEMYDMGGFNSDGYFTYTAQNWGNYQLDPFTNGSDLGNYFPSMELDVSVETDFVHAPPAADLSSLAQPSEVDPALAAMGELFMATTTYPSIISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKR8</accession>
    <name>A0A8H5GKR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKR8"/>
    <dbReference type="OrthoDB" id="3264316at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="182" mass="20779" checksum="71F9BD264CA97FCB" modified="2022-01-19" version="1">MVTIALKVVDCILRQLQEQFMQIEFIGKLPSAVPSHAEWGLRCGGQIGSHYWICCTRSYRRTWYFADVTSSLKFLTINVDHPRIFEAAHRTMEVITHKNIPSNIPRHLNEYQQAKALFEHVYESYSQAVPVGLNGVSPREPKKTSSNDKLFESLWNEMPSDSEDESLSDIQGSSSQTSDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMM0</accession>
    <name>A0A8H5GMM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMM0"/>
    <dbReference type="OrthoDB" id="2899474at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="34669" checksum="D3B758609CA549B9" modified="2022-01-19" version="1">MKQTYVIRIDERTQKLTRRVKNFVCNAQKGRWSAGRRCLHVERSTAPNSTPLPNPGWERIYRDAFLRQLLNKVLRNFHLHFVVLVFSSFSSTSTIMSSNMRLAQNALNVLQKAQVPSASSSNLAAKSLATRRGSANRGASGSLRASLSMTSSRTYGTVTDYRPRSDDPNRPLTRDDFISPMTLDLATNLPVMYVLNDGAEGLSKVPTPTSIRDSGKIPEGYTIDFTLDPSRIIASLRTAGVTTIGQCPEDTLYEIRAMVNSPQNLSIVPTSVYEARRRREFEQMLGESSSSAPQQQQQQKSSSSQPKNMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNA5</accession>
    <name>A0A8H5GNA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNA5"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="68506" checksum="465AA3B1C2D14FCE" modified="2022-01-19" version="1">MDFGTNTNGRERANSGRKNHRQTKPKAGKGKKPAQVTNPRLQCICVRCGRTLLISDYGNIQGDRCDRCSGPGAADADVVHLTSKLNNTHISSQAQARIPQWKPGDLDEEIIDTGPAFQSAVQVLSTCHTLIVDCEGLHLGVQGGVLSLLCMRSVSVSGTPHSYLFDIPLLERANVSLQPVFELLNSANIRKVFYDGRMDFCAIYHRYYGPRPGRGSGFNNLIDLQLADVDSRVMRGETSDGQMKRLLRCLPHSQVSKPRNAGKYTDVHLLQGLGNCLIEHGVAAPPKGNVDHSTWMNRPLTDEQRFYAANDLYLISLLLAHFESAGYLSQDLPVWSQRYICLWSDSQPTEGSRYRSHPLLPLEILRFGPTSTSTNNTNPSLNRRCDGCQRYLSMSSFPGLGPTNEAQSRGYGRGAQSQSSGNGGQEESFCFVCMAIPHWIKRREHFAELKRKKKEEREKTEAQKRGEEMVRLFGGLPKAQAPTSSASASGVADGNGNGPGPGSGVVPVAAEQGPSGVVTRGASEQSQSGDSGGRGGRGGRRRGRGRGLQGTDTGRGGRGTTMARGRGGGGERGGSERDGRGRGRGGIGDGRGGRARRGGGAGRGGGAPALPPAPALPPAPAPVRPPPPRPAGGGGGGGGWWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPM3</accession>
    <name>A0A8H5GPM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPM3"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="394" mass="43596" checksum="F2D89937088F00EA" modified="2022-01-19" version="1">MASKSLITKIEMFRVPPRWLFVRVETTDGIVGWGESTLEGHTEAVEGAFGDLQRFIGAEADNIADIWQEAYMGRFYRGGPVLMSALSGLDIALWDIKGKKYGIPVWKLLGGKVRDRIKVYGWIGGDKPDDVLDAAKARKAEGFTCVKMNATDIVARVDTPAVLKGTVERVRQVQSVGLDVGIDFHGRLHKGMAKQLAKLLEPLHPLFIEEPLLPTQPEEIADISNAVSTPIALGERLYTRFDFRPYLERRVIDIAQPDVSHCGGITELHRIAALTETYDVTLAPHCPLGPIALAACMQVAACAPNFGIQEMSWKMHYNITAEDNPDAEADLFTYISNSEVFAVKDGHISVLEGPGIGIEIDEKRVREASQKYVTTQSPWRNPVWRGVDGSLAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPX6</accession>
    <name>A0A8H5GPX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPX6"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="105" mass="11665" checksum="EC754BF0E7DD5DD5" modified="2022-01-19" version="1">MADSLSPECTPLKKEYDACFNVWFEGYLEPAVSASASPQKQAESSQRKAEEFQQKCGKIWESYRGCVQKALKEKGLDKLLEQSRTENPLTEPPQSSMPPSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQQ5</accession>
    <name>A0A8H5GQQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQQ5"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="37408" checksum="CCBFFDC35267EF99" modified="2022-01-19" version="1">MSMKACIGTEDGKVTLGSLPKPQVGPKQILVKVFAAAQNPPDWYLLERRTSTGAVIGCDFAGIVEEIGSDVPAGVRKKGERVAGMIRGGVKDQWHGTFAEYCLADAELAVSLPDNLGFEEASSLGMAAFTACQVLWQNQKLPTPEKPQSFPILIWGGSSTVGQYTIQLAKLSGLQVITTASSKNHDLLKSLGADAVFDYREQDVSLKIREFTENKLAYAIDCVSEGDTPKHVGDSLGEDGGHVTVLLPVQVPREDVTSEFNLVMTLFGEAYIVPPHSLPAHPEHYDLAKKWVKLMSEQLASGYLKTVPVKVVPNGLADVMKWLEYHRLGKVSAEKIVYRISDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR20</accession>
    <name>A0A8H5GR20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR20"/>
    <dbReference type="OrthoDB" id="2935230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="38532" checksum="E2CE336D7C2B3DE4" modified="2022-01-19" version="1">MTSVQQSSWPAPPQSYRNAVAACCMCRTPSLTSKDFIFPLAEMPTEIALNILVEASIQSQSTYLALLLTSHAIHRIIRLEVIPNLPITLTSKEQVYSFAELVAKDSAVANRVRYLWMIYSLEPSAPWLQILEHCTELVSLACSSDMLFGIDTRRHKRLRELTVMKPLPPVHEALYRQLEYLHIMEGNGILWTHTITKHNLPMFSNLRSMSISISGLPSIPVAAYDDQLRVRAPKLEKLAFVVSRLRKGTDVLGLSSIVENHGKERSYPVSLVFSTRRWTEKKMWQARIGDRASVWKLRNAKDILSLIHSVPLGRPRIQDGQTETPYVSRTWFLTFKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRI0</accession>
    <name>A0A8H5GRI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRI0"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="28283" checksum="BC1D3A5F23BAABE7" modified="2022-01-19" version="1">MAPRKRRATANTTSTSMRNATTTWATATTSNTSTSTKGSSKRKSPFGFERFRRDEFINLSSGFTLLDTLESYFDSQVDLFQRQLSNARMSYARERQTHYEDACGQPQYQDIRKSKTEGYFGQGFPAFDEELFDSGDLLAENSDREFKGFKVNHEYLNCPTRAWHSAKVVQTREKVSFFFWFHVGVVRMGPHSLSSLSPSLRTYIYKKRVWYYFLFDLRASTSLSSVSYTSGSPLPYELYSLRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRV5</accession>
    <name>A0A8H5GRV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRV5"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="135" mass="14777" checksum="C5D19496306FC9A9" modified="2022-01-19" version="1">MLAHRALHWTTGPQEVLSIPVRALDYSSLQQAFDEIVDLSTSSSGDSGFDVGFGFDKTSSIPSGGLSCAIQALYIMLVNVIWKGNKPQKPSGSIQVCTEYISLGYRPRNAGIYQPRSMFYGPLREPVSSNETKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTA7</accession>
    <name>A0A8H5GTA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTA7"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1003"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="711"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132161" checksum="406E9C959FF07319" modified="2022-01-19" version="1">MDTNSLPLNPDQICPGCKLSAVSDQGGLVVAFGQSLFHVDCFKCAKCANKVTADTNLLLLSDGSPICADCSYSCNVCHLPILDEAIMSGEDSYHAHCFRCKVCKNRIDELVYAKTSQGMYCMDCHNERMIKMRRHTQRKREKEKAAAAAAASANSSQSSREHPSTPSKNLVFTVAPPADEQPSERAPVFHPPPRTSSVDHHQTPRPPPLNRNHSYPIPDSEIPPSDQLSVTSKRDKRRSINPGLSLHLSEPISGRSSPTLTPESIKLASSTPSPTPPAQNGVDSPLRDYFSTSRPISNGSLHSQRLRKVSAGAEDQTIVMRPSSPNINRPGSSSTLSIDHPRTPRSPSPASRSRPMSRADVPQSVESATDESDDDDQHGIINHYRDSSEGSIPPLPPSKDRAPPPPPITLPSDSENERLDSSALSTTALESDASESSPVERRTSRATFIAPALPPIRFSLNTADFSDLFSSVGGHSLKNLETLANATDKQEHKPKRIDEEADVPNTPPPTAASVQLNGHSADDYESGKLDRSSSVKSLRTLGREAEATSRQTTRGRAASDSRNGSSDDLVTPIAQITLTPPVNGTSKAAKTDTSPDLVFSRLQEVMRDAKERGAQQLKLDRGFVEAIVEAMAVRKAETSELRGSLDGMKRASRQYIEGLTVAQTEYDRELKARRDAEAEVTRLRVLLSGQAARLTALTGDSKKQELRQQMTKDLNDNLSGLERDLSKLKAQRDMALVEVEELAASKSSAPEGATNLNRSITKRLDTLKTQYQRDLVPLVQQREILAREVMELKASRDAFLEETTVLNARNEELAQLSAQYQRRMAMAGQQSDSKNTPVVVIESERKSEDRGRSQPFPTQPTANHLNATPYSISSYPSTSTLGSDETVDRYQKLPKIPEVEIITPSKGRLLKWGVSKAKDLAVSSSPSGKNGSTVHNFQPLSLLRFTRCDHCGDKMWGSQLRCTGCNISVHTRCVSHVHVGCSQQTSKTEQDEPQALPPSMFGRDLVEQVRADARGGSRKVPVIVEKCIGAVEALAMDYEGIYRKTGGSGQSRTITQLFERGDYDSFDLCDQDRFNDISSVTSVLKTYLRSLPIPLLTHDLHDQFMTAVQVRDPAVKSSSVQELVNKLPPEHYCTLRLLMLHLNRIMEQSEINLMNARNLGVVFGPTLMRSPIPGAEFSDMAGKALTVEWLVENAPQAFNPSKHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVN0</accession>
    <name>A0A8H5GVN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVN0"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="36947" checksum="C53F442151250A1E" modified="2022-01-19" version="1">MSSTTYESIQFRGSPSGEVVQKTFTYDGLAPNEVIIKVTASGLCFTDVHMLRSDLVLGHEGVGIVQAVGSGCKNVKVGDRVGWGYLNSTCQTCEYCLGSDDPYCPQKEQFGVNNHDCGSLSNIAKRKEDWLFKVPPEMSDIDAAPLMCGGTTVWSPIIRNCKPFDRVGIIGIGGLGHLAIQFLRKMGCDVVVFSTDASKREEALSLGANEFHCVKGLQKDYGELGIKPIDKLLISASSKIPMGQFYPIMKPRSTIIPLSVADGDLTVPYTQHVLTGMALQGSFISPKLEQQRMLEFSARNGVHVMAEKFPMTLKGINEALEKLKNGKMRYRGVLIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWK7</accession>
    <name>A0A8H5GWK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxal oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWK7"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="2">
        <location>
            <begin position="157"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="318" mass="36233" checksum="2714A7313B6776DC" modified="2022-01-19" version="1">MPDVVQMWYEYKQDVIWKAADCSHTDGSELKPLPLLCPPLCLLLKCRIKSSKISLFLKLHLPNTLALQAKYADSELEKMKEEVLLALKETEDEYEELVERKKDERTIEIMQKLSYTYFHCNYPCMDRYIALQQHFMILVKPERFLGWITDNSTIINPTYEFYPPKNIHGQNGTPIYSLFLQNTLNTNHFPLVIMLPDGNLFITANMQAMIFNWKTNKHIQSLPGIPNGVQISSPLSAGATLLPLTPENNYTPEILICGGSMLDDNELLFSQGVLSSQSPASDQCVRMVLNDEGIAVGWQVEHMPEPRIMAELILLPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWZ8</accession>
    <name>A0A8H5GWZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWZ8"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="399" mass="45289" checksum="B00081B5255D0289" modified="2022-01-19" version="1">MATIQTNSIPKSYSLPQSSGAKIASPSTRRLLPTGPAFVSHLRLTVHHGHSFDKHDEFVEKERQRLEELQASTSKSGEDDLGVGDEPETEELLSLDPKEWKKHDYYAVLGLSHLRYKATPEQIKIAHRKKVLKHHPDKKVTTTVTPQSTSSLLTGLNLNTNDDAFFKCISKAHEVLNHPEKRRQYDSVDHQLVEEQEETPTAASFKSQKMDFFKAFGPVFEREARFSRKQPVPMLGAVDASKEHVEGFYDFWYNFDSWRSFEWLDKEVNEGSDNRDDKRYTEKKNKAERARRKKEDTARLRQIVDLALSLDPRIKRIKQEEKQAREAKKAARSAPASGAATPKKSKEQEEEEKRKKEEEEKVAKAEAKKAKAAAANAAKKARRAARATEEGVVGNGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX75</accession>
    <name>A0A8H5GX75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX75"/>
    <dbReference type="OrthoDB" id="3269397at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="459" mass="50778" checksum="CA6BB7C085A43DB0" modified="2022-01-19" version="1">MIGVYHMTGTMTGTEIEIVMTEGVLHRATSMTEIGLERGTDLANVIMTVAMTAILLAETRLLVLLHVTRSTDLVQGQDHLYEDLLLPLLLECKLADVLRVLVAHLPPPSIRAFSPTTSFTFKAFTLPRVFTLKRWTKRSDRGSEISARHEGLSPVSPNPEPEIMTKAHTDQRSQTPALPSVENKEVIDSQRHEDVAIKHEHEPAMDAPFDPPLSRGSQTPSYHPPQQDGKEDKSMPDAEGDIVMKSEPEPPPSISMPVPLPTKPRGNSSPPRQPRWHDTRGGHPPTQPRHHWQRGRGAPFRGFPYDPPRAPRNHPIAASGMSQASPVQTATPNLPTPAPAPDGAAVTNDPFANIPEPIIPDYKSLLKLSPETETKVQELDALRKQIALQQKHAFNLTLEFGNIHKTTRRALHEFEMSTFDLRAAMARRKSTATQLELARAGMLGIDFEGDFSREGSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXN5</accession>
    <name>A0A8H5GXN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNK3P-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXN5"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50430" checksum="9FFC8546F510B534" modified="2022-01-19" version="1">MSSVAGQYITRSVSLLNRVCAGPSNKKRTIDQGSELSEGSKRKKIHPFFTKATTTQESDSTSFQWQKPLGVHGTCLHGVNLSPISSNKVAAFDLDGTLIKNLKGSLWEWWREMVPSRLKELHNEGFSIIIISNQALKPAALVNWKRKIESFAASMSSTPFQLFAATAKDNYRKPMLGMWQELTRIYKKDGVEIDKSNSFYIGDAAGRLYPGGKADFAATDRKWAMNVELPFYTPEEFFLDRPPHANLKLEGFNVSSLVELPRIAPTNLPLIPESNQPEIVLFVGYPALGKTTFYREFFEPLSYKHINQDTLGTRTKCIKAVQEAVENGHSYNTNRDRQTRKYYVDVANRLKVPIRCFLFAGSMALAWHNNLYRAYNLPPSVREKETQREILPYLAFTSFKNNFEEPELSEGFSEIRQVNWSFQGSEEERKYWSMWLQLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYN9</accession>
    <name>A0A8H5GYN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mnn4-regulates the mannosylphosphorylation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYN9"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35245" checksum="C0F6B76BC6FFD320" modified="2022-01-19" version="1">MSSILRPFARQLTPLALRASKGPIARPATLNLNSTFLQLHRRTVASTVTNKPASQSFDHAAQNIREEAGNSAADLAKVIAGANMTNDAIKTEKGFFGITGTIASEVPQSVMVFGLAGGLPYIGTAATTVYLAYEAGLAASGVPINIDPGVAITVLDQALNVQVTYGAVMLSFLGALHWGMEFAGLGGHKGYARLALGAAPVLFAWPTLALQPMTALVLQWVGFTGLWWADAKATSMGWTPKWYSQYRFYLSILVGTCIIGSLAGVSYYGPVGGHGLITHDLELIREQRKELLADKKQGKIEAGPVIARPGSLKDEAFVKLSKKKEDEGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYX4</accession>
    <name>A0A8H5GYX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYX4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="301" mass="34105" checksum="C41197DEC378751E" modified="2022-01-19" version="1">MLKSVFSRAPWEPLSFPNKGFDPIPADKVVEEETLPDYVATRYYPVTIGEIFQDRYQVVAKLGYGATSTVWLARDLSGHRHVALKLFIKSESMGDEVVRELGVYKRIERTSKKHPGRSAVRSLLASFEVEGPEGQHLCLVHPPFLESVRTFLRRNSERRLPAVVVAFILKRLLLALDYLHNECHVIHGDLQDSNIMFDTTDTSVFKEFEKAELNDPCRRKEIGGRTIYESRKLEKPIGLGAPIVCDLGSALALDDGKEHREVIQPAFYRAPEVILGAPLMYSADMWNVGCMYFFLANFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0Y9</accession>
    <name>A0A8H5H0Y9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0Y9"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="46734" checksum="6F9126444CF679F5" modified="2022-01-19" version="1">MPLPPRPNFTPQNHNSYATSQAFHGIPPELANPFPQACSSHYAQAYMQNYAPQPLTTPEGYTYSSTYTSAAQPTLQYATAPKPPKTSIFAANSTWYQPGNVRCTYKNCTFTGSSKTVEIHMMDRHLIYPPGWEKRKKTQDWDADPSFKGKSIPIQGTKILLDTPAAVEAWIAERKKRWPTSERVEEKKRKLEEATARGQFTAEELGLFSKKRRRVEDDNHVNNGRGRGMRGRGRGGRRGGFADIGLRGRGTMNEKQSKEINKPEAMDDATVPTPQAPTLPMTNTADSSLSDDSDDDSEPEVVSSKVSSKVDTIASHQTNTDALVEDPKPAPKETKPPVLNRQPRQPKRPPPNPFAPKTSLLRNLLLPEIRMTVSNLSQAIRFIVDNDFLRDVEVKPGEADEALIKVESSTTIDTDSQSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGP8</accession>
    <name>A0A8H5LGP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_008288</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGP8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5356572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58616" checksum="6E8226E79378F92E" modified="2022-01-19" version="1">MTYQGTEPLALVGVFVVVLLAVLYFDGSRAQLPPGPPRLPIVGNLKYLTVLGRPKPWHLFHKFAQEYGPLTYLELLGKPVVVISNAETAKELLVRRASNVSRPRMIVGNEYVSRNLNFIVSDGDIWRRMRRASEAQLGVKSLIKFEDIQTDEGILFAYDMWMRPEKRQENILRVTASAILSVLYDQPPLQSLDNPTVRLMDEYAHRMRTAVQPGANLVEAMPILDYLPTFLAPWKQNANKDFQIFSSMFLEKFEAVKNIGTLSGEQRPSLCAKLVESGPRHELNDLESAWAAALIYGAAYETTSASLAWFLLIMIQFPHIQQKAQEEIDTVIGRSRMPSFSDMNHLPYIRALMREILRWRPPAPFGVIYQSVKDDYFDGKMIPGGSVCIPNIWSINRDPEVYGADAHAFRPERHLSSDGKLKDEKDEGHFSFGFGRRECVGKYYANKALFIDITMILWGMSIRPAPNGSGQIVIPSISEDVGEGFVAFPPPFECKCEPRFEGAEATLKQARDAVLSAHGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHT5</accession>
    <name>A0A8H5LHT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHT5"/>
    <dbReference type="OrthoDB" id="162969at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="11555" checksum="19C26B3385FD4C0E" modified="2022-01-19" version="1">MKWHLQNICIAVQEAQEARENSEINGGDDDADDDAPLEDRPSRREAMEAVSVLQRYTHEIDEPFARKLEVILASFGRQTRLEATHAMHDTQITQFFQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIJ5</accession>
    <name>A0A8H5LIJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIJ5"/>
    <dbReference type="OrthoDB" id="2790258at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="865"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5358805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114422" checksum="BC28879A2E3C16B3" modified="2022-01-19" version="1">MCNKFQISDMNPLGNIPTTPIRNGAPPHPQYPSEATGLQSSVPLQSPSTPVLSQSPYPIQYAQYHPHLHYHGWYTPYPGTPTPNTAYPSTPTPNTCSGARLSAATNVIDNFRHYQPPNSSRSGPNTIQSRKRSNPTLDSQNTRNVRPRTSADKENSNVSVPSQSINPTPTAAVAGAGPIPASSLSTDTPLPPALDSAIFKSAKEKQKKADSGSGNSAATDCWHFIVPADTHAVPPINPNMKLFRKRPSKCLFLACRLCLEGAATQGIFQNGGGRLTRNIRRHLKTHHGPIYNEFVLKFKLKGWESIDSTGVPISKYDRRPNEEFSPKVFMELLVRWIVVDDQSINVVEVPEFRDLLSYIGLELTSGEIPHRTKLMELIFAQFEREFSNVKAEIQNSLGRNLEGYMAVTAHYMIQKDGHLVMKSRLVAFRHVEGSHDGLNMATYFFTVLKELGITNRIGMITLDNASNNNTMMRSLERVFHDIDVEFSAEGNCICCFPHVVNIAVKTGLSRLTYSDQPQGFDDADGVTEVEIQEFLPTHPNDDIPADYRAALQTDLVSKVRKLVNACQASGKRRANLHKIIIEIREADLKKKEEEGIQITDEMEEDVIKVVVLLRDVDTCWSSIYLMINRLLDLYEAVQKFAQLDENEEIRSLLLSQAELHVLKDIQLYLKTFHLIQELVSGQKTPTISFVLPLYEQLIANLKTLKIVIPRLSHMIESSLEKLYEYVDKARSTHMYAFALVINPTSKMRWIEQQWSAQDASNAKSAILDVMTRHQTAARHEQVASKVPGRVSVDFGGSNAAHSLQAGFDNLDVFTECLQALSRTASASSFADEPATTLDQNNTDPSTDLERENEALIKDRRMAEEELHSWIGEGILKDKKADLVRFWDDKTRQDKYPSLFRLALDVLPVQASAVPCERAFSSSKETDADRRSRMSTVLVEVLQILKDFYRDDRLNFSAAWVAKPSEMAEEDVHGYCTESDIVRDDGLTTTDLGNDQLREMLMQGQVQDLLNLIEASYNTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJU9</accession>
    <name>A0A8H5LJU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_007615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJU9"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5360006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="546" mass="60360" checksum="BF11E849737308B0" modified="2022-01-19" version="1">MVNLGRIEDRPTPREVYSWIIYLNAFVATFAAVMIGYDSAFIGTSLSLTSFKTEFNLLDKTTSQFNFISANIVSLYQAGCFFGAFVGYPIGHFLGRKWGLFISAFIFNVGAILQVVANSSTGLGLMYAGRVIAGLGIGIASNLAPIYVAEIAPPAIRGRLIGMYELCWQIGGVVGFWINYGASNNISEGHTQWLLAFAVQLIPGGLLMLGSPFLVESPRWLMSRDRKDASLACLSSLRSLQKDHSFVQREYAETEETIRHERSLAGAGFWGPMLTVLANRKLVWRLILGMSLFAWQNATGINAINYYSPTIFKSIGVTGQNTSLLTTGVYGIIKLVGALIWLLYLVDQLGRRSLLMIGSIGGAISMYYIGAYIAIAKPQNNPTSTISSSGRSAIAFFYIWTIFYSPTWNGTPWVVGAEFFPQHVRTFTSSCIAASNWLFAFLIARFTPQMFTSMGYGVYLFFASLMICSVFYVYLLLPETKQVPLERMDELFGSDVKAWNAHKIVMARMIHQNDTSKNSFSDGGRDEEVGMKDDGSMTKGVEARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK91</accession>
    <name>A0A8H5LK91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK91"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13591" checksum="FB5D931031E7B0B1" modified="2022-01-19" version="1">MAAVAQKSAINIVLGTMTFGFEGKGGVRVHDLKTLGEIVNVFKAHGHSEVDNSRYYGEGTTEEIIGQIDHTGLKIQTKLPAFHMKTGHSGQQKGARHEREVEDITHNYEDMKKKHPHLFETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL52</accession>
    <name>A0A8H5LL52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL52"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22489" checksum="F0DD772D7380F753" modified="2022-01-19" version="1">MEKRKVVRFTAQWDPNLELQVWDDKEAATEALREDKVRFQFFTDGSGKDRGVGASVVYYQDGQYKGALQYHLGSENSHKVYEGECIGLILALHMLTKVAQPTSVSIWADNTAAITATDTSTRSLAHYLHDIFHTILITLRKRHPPFVSYHILGTRPSWCIVLHWLDSGSLRLSYEQLDEVITVAWLSSHKQLVDSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LM48</accession>
    <name>A0A8H5LM48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SURF4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LM48"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5362600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36056" checksum="2552DA79E94E659F" modified="2022-01-19" version="1">MTSRISIARPQSATSYNPDPHGFSNSRPSSGYRSANPDDPVEKIRAFSKQVEDNVEIYSQPLKPHLPAIGRFLIVVTFLEDALRIMTQWGDQIWYLQQHRKFPWGISHLFLIINVLTMIIASGAVISKRYTEYAVAGLLSVVIIQGFGYGLIFDLTFFLRNLSVIGGLFMVFSDSMITRKTPFAGLPTISETDRKKYFLLAGRVLLIFLFLGFIIQGDWSIARLFVSTVGFAACVMVAVGFKAKWSATFLVLVLSILNVFANNWWSVPSAHPQRDFLKYDFFQTLSIVGGLILLVNMGPDDVVVGSFVDMEYIQVGEDLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPM4</accession>
    <name>A0A8H5LPM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPM4"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5364808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58306" checksum="57855F0C009FED00" modified="2022-01-19" version="1">MSDVEKRVNEKHEGGSDIEEEIDLANFHEKRAGRLVVDPEEAKVEFGEAFTSRLKLSRDGTKILWPQPTDSPHDPLNWSDRKKAMHLLIITLAAIVPDFDSGIGIAAIFALAKQYNTDTDTINNMTSNWSIFLLGWGGIAAVWLIRRYGRLPVLFWSQIFALGFLIGCTFAPNLKTFTAFFGTAPQVTGLYVVTDLFPFHLQARKLNVWTMGFIISPFLSPFAFGFLVARTTWRWAYGIGSIYGAIVCALIILFMDETMYDRHVKPIPEPMANGSLRYRIETLVGITGIKMAKYRISWFETISSPFQVVWRPHLLGILLFEGILFGFGIGINVTNAVFLGSPPPRGFGWTEFAVAGGYGTPIVAVLLGELIGRYNNDFIQNWSIKRNRGVFYAESRLWACYLAMVLYICGFVLLGGALQNRLSPGAIIMGWGIAETAIMINTVAVYAYCNDCFPKHQGEISALINLARTLGGFSVAYFQVPWAEKHGALQTFGCEAAIVAGLFILIVPWLQLRGASLRERFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQR7</accession>
    <name>A0A8H5LQR7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glycoside hydrolase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQR7"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034721314" description="Glycoside hydrolase family 31 protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="11">
        <location>
            <begin position="89"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="424"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="12">
        <location>
            <begin position="783"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5366038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119746" checksum="84110151C3771A8D" modified="2022-01-19" version="1">MRWLALLSVVLAIPSALAVKSGDFKTCSQSGFCRRGRALAARASEAKVSNVAWTSPYSIDPSTLSISPSNATFTASVKNSLYPDITFGLELRIHQDGVVRVRMDEVDGLRKRYDEAASWALIAEPVISETVKWKASKEGVSAKYGLGAGDDDLEVVVEYQPLKVTLLRAGKEEVVLNGQGLLNMEHFRNKEEPKPESTEEVVADTEGQQQEVIQQEQEQEKEPEVNPRAWFEGDTEDDYWDERFNSWTDSKPKGPESLSIDISFPNHPHVYGIPQHATRLSLQTTTKFGSNSNNEEGDEDKPKYTDPYRLWNSDVFEYLADSTMSLYGSIPLMHAHSSESTVGVFNAVGSETWVDVSHPSSDVFMNGKGKKKAKKNEENGTLTHWISESGILDLFLLPGSSHSQKSKPTSDVFTQYATLTGTVSLPPHWSLGYHQCRWNYVSTSDVRSVQHNFDLPENDIPVDVFWLDIEYSEEHKYFIWDERSQAFPDPVEMINDVSAMGRKMVIIIDPHLKRVQSYPVYDEASKKGLLVKNKDGNEYEGWCWSGSSAWMDCFNPEVGEWWVQKFKTRELGNGEFSWVKSTEDVFIWNDMNEPAIFNGPEISMHRDAIHYGGWEHRDVHNINGMLFHNLTSLAIKHRSASSPTQPSSSTSPSELTRPFVLTRSFYAGSQRFGAMWTGDNLGTWEHMAVGIKMVLANSIAGMGFAGSDVGGFFGNPEPEMLVRWYQVGIFSPFLRAHAHIDTKRREPYLLDEPYKGIVKEALRLRYRMLPIWYTAFREMSVGGKPVVRPHYVEFPQDPNGFDLDDQFFIGSSGLLVKPVTEKGASEVSVYLPAEDEVYYDYFTHTTHFSSNRGKGKILTLPTTLSHIPLFIRGGSILPTRERPRRASPLMAHDPFTLTIALNKEGSARGEVYLDDGVSYRHALGGEYVWREFVADVDATKKGKKKTVVKIESRDLGKVRGGEAVDPHEVRDLTTSTTAKTTLTPYASDNAFAKSIQDVRVEKVVVLGLGGKPTSVKVVGGGDNELIWEFKEGTASSDSKKDKDGGVASELVIKDPRVLITKDWAIVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR45</accession>
    <name>A0A8H5LR45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR45"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5366399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35164" checksum="BB7FFA55D4959EDE" modified="2022-01-19" version="1">MIVGHSVSQKIMFAAIYGIEISSNKEDMPASNREIFDLDVGGNTIIPGWDGFKYIPFIQHFPSWFPNGQLVAAHRALGQMTETGVNQPWNAVQEKIKSDGDYSSLIAKLLSKTDPGNDEEIHRIKWFGFTSIAAAADTTMSAISTFFVAMSLYPEVQSKGQEELDTVLGKGRMPTFDDRPSLPYIEAIFREVMRWHPAIPMGVPHDSTEDIIHKGYYIPKGTSIYANIWAMTHDASVYKDPDQFIPERHLHKDGHFDNINSILAYGFGRRVCVGRYMANDTIWLTIAMTLAAVKISSLPNKNVEDYFSDGAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRH2</accession>
    <name>A0A8H5LRH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRH2"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="205" mass="23566" checksum="70800F970FF8E21D" modified="2022-01-19" version="1">MSAITRNRQMPSITLKTELIGKVTGRKIDTNALIDSGAEGIIINSQFAQENQLTLLPIEKLFPVRNVDSSENTMGWVREYTIQNLRIYSQDNRAYHEEKAEFYVTDIGDHDIILGTDWLEEHNPDIDWSVSRIGMIRCPETCIIANPPILHLKTKTKPLKSAVVDSRTHHKDYQVRWLEPIGRFKPVAQSKIAGRRHQIPIRSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUB8</accession>
    <name>A0A8H5LUB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUB8"/>
    <dbReference type="OrthoDB" id="3255922at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1092" mass="117168" checksum="FB426374E9FC8108" modified="2022-01-19" version="1">MGLRLMPNRPANCLSYNSCPPAYHASNAHMSPALIKHYHPLALTLPVHTYLCEDLPPHIAFLPQKPKEDTDNVLQRRFEDWESGRKGLQMPKGLSFRIFKGPTVSSSTFPSLPVYAGSGPFAGTTAHFDIGYHSIPLNDSSRNRRTSLYPSGISTAPSIYAPPRDHLNTAQYTSGVSPPASSSNSSSGVRPVSNSRSNSNTSPNSSSNKNHRQFSIYASNVNQDTFIYEASDICSNSEYSSSHVSPSPVPYSPALSTDSTVTLRSPLSTSSLLQPPDRAPDRATTPAFQKGAPPPLGQAQDALRDILGNHTTPPSAPNTTFRTTSPGSNGLPRRSSPPQQAPRRRDSGIIPTFSLAENDVDTDTETESDRIAWRNAERNSSYSSVPAMAMGRRRTLSTLSNISSSNISSTIPVVPLTMSYFPPPEPLPNPPRPASFLSTDSTGIRTATAPSLSSLHQHQEVTPDPLPVPHAAYASASAGAAARSAGSSSSSSTIVIDRLGDQVDDTRFFDEVPLRSSPVEMLNEHRGSSSELPAIPDPTLTTIYSTGRGVDRYPSPSDNFNVSSGVPAAASSSSSDRSALNYSPSRHSASRTSPSAPSSSPSSRAAVAAVSVPAPPDASSLGTQGLPLHEGRSFVGSFVPSEDAYYSPAVPETATPAAAQPAYTRFSLMQVPVPPAINPPTAVEQVSTSTKLTSHHNHPPSQPSQHISQSNRDATASVEAAADVSHERRRSSRSRNSISGVSGSGHKSDRSTSNSPPLARSQVPAAGVQWPSSSVVGTENVQPGLNRAGTMRTQVEVAAASSTQQLPSSYSSSTQPAVTNPSPQNTSRRVRTTSISSVQVQETNKRDSRRSAYPPDAPSSIPVQTPASSNTRRTSPEIPIYSTPQYPPTNEYPKPEPRRRFTDESNPSLADATRRAATPFRSEFIPSLSTSRAHAQSQAQAQSTPSQGKPERSRSDGDQLPIANPSSAIRMTTTQTQAAQVTVVSIESQLPEPINPAQRTVRWNQRLVCPSPIHLGQRRKGWFNRRGDQLWTNGGLFKSPPPGEEYPVDLDDYPDFNEGWMNEEGTRIDLGHRLIPKPPLRSALKRTSQNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV70</accession>
    <name>A0A8H5LV70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA ligase</fullName>
            <ecNumber evidence="9">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV70"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="12">
        <location>
            <begin position="525"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5370718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="849" mass="94047" checksum="CADF398EE22D6A85" modified="2022-01-19" version="1">MSKRPASSSTPAKSKRTKTSSGQKTSPGQTRLDTFFASSHHDQQPSSSKPTNPMVPKIHKGSPEIIDVDLLGDPVIPSSETEVKVAKETPIPRSLTSPVKFIQVKVAAADALPPSYATLSADCATFDPETYELPSSLEIPYSFLAHALSTVCATRSRITILDTLSNAFRVILTRHSQSLLPAIYLLSNTMSPPYSSLELNIGPSVISQAIQHVSGLTPSALRKLYNNFGDIGDVAFAAKSNTRTLIPHPPLLVSFVYKTMYKIATSHGQGAAKQKQKLVETLLVAAKGEESRFLARTLSQNLRVGAVRTSLLTALARCFVLSSPCRGSTPCPYHVSAKTLATIQPLNGESKKGKNIDTARETLNAACKESETLVRKVFVQHPDYEHILGSLIEDGLEMLAQKVPLTVGIPIYPTLGTPIRSFEEVYERLKGLPFTAELKYDGQRAQIHAHRQVDGHIMVRLFSRHLEDMTSKYPDVVALVEEMCGRNTEIQSFIMDSEIVAINPADGSLKDFQTLASRARKDVRLGDVSADVGVFVFDLMYLNEQALLTHPFRSRRALLREHFPPFVPERKELARFQHVESCDSEDGKTSIEEFWESDVGRRDTEGLMVKLLDNETVKQQPQERVKPLLAVYDADKRTYAWMKLKKDYVNGLGDSLDLVPIGAWHGNGRKAQWWSPILLGVWDAKKGRVVGVCKCMSGFSDNFYKCNTVLPDIDTLLKALSERYNLSEDSELCSRVSEWNCETGGLKPDVYFKPQEVWEIRGAEVTVSPVSVAALGLVSSSKGLSLRFPRFVRIRQDKSVEQASDTVFLANMWRKQKGEKDLVDEGDELIDVDLRNSEVEESDASSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV89</accession>
    <name>A0A8H5LV89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV89"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="368" mass="41591" checksum="ABFC5B0FDD0BF820" modified="2022-01-19" version="1">MAYSYYAQRPAWGTNQFQFEAPPAPAFQPQPSWRGLDYYRAHAISPDPSLYNNAWSAVRHPGDYPGIGMHENRNVGMHESRYWHNRVYSGYSDINSMLPEEIGHAAAYEAHRHFLHFSGTLYGPLGGDLEAQREAFVGWTIGEVSRLYEYSSRRPDGYTLRRATEAAAATASRIFYESRNGYDDDYDRGRSTCRRSAYGDAYNIDSAYYPRPRSHSRRRSSSAYRHPLLQDSYHTDYPPTSSMPIPTMGSSVIRSGYPDSYGSYGSYASSVSSAYSGGGSVMMPGTSPSYNPGDAASYSNALVPMRSRHTSISYPYAPTQPQTQYVHSAMPAPPHEIVIYKPKSHRRRHHKHRSRARSVSPNRYVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVU2</accession>
    <name>A0A8H5LVU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVU2"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26557" checksum="511A908AB50B1336" modified="2022-01-19" version="1">MTAIKYRVLVTGYGPFRNYKENPSWLAVRRLHDSVIRTSASSSATPESIHISSLEVPVVYSAVLDIVPGLHAAPPVLPSSVPKDFPTPSQDGYNLIVHVGVAGPTELRVEIFGDKTGYNIPDHEGKYAGIVEEKEGEAPVRGFADERYGMFPERLQIRVPVDPLLEGCAQDGTILVTSTDAGHYLCDFILYCSLAESKMAGRNTPVLFIHCPPIGEPLSTEQVAEGIKSIVANVCGRLKPVSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW61</accession>
    <name>A0A8H5LW61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW61"/>
    <dbReference type="OrthoDB" id="3250441at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="254"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="56227" checksum="72B584BF3C8A59E1" modified="2022-01-19" version="1">MQPWSVRYPATLMVCPPTAFADLGLIHDLPDQALRGRVSMMQEHNAVMRRFALIASPSICAQNPDKCLNGDHSICAGRPVQYYGPLNALFDPHLATLSHKLDNLETVELTSDMVDFAGRLFSMSANLCSAENQRQVPVFELLREMFPGGSAKPGVYWPHSLIFELKNEKGSQGNPQVQAAVDYINIFCDNALSRHLWGRSNCPSVLLSLAGTELMISSVIFTDTVYLNTLYSEDLSGSFDMDKRVVRLARALQALKETFVGLSKFYTGLKTNPDPAPRGGSHLFPKPVRVEGPDDEVLLETLGLRFIKKLSRTGVQVVNAEEERAERQANMTHAIYVATSSGRCSSIPVGEVVVKFAERYNVEAHNILANANLAPKLYYHCAVLGGCTMIVMEHIQGKMALFWEIENRKMEKTVFQDIGRAINLLHENDIVFGDLRLPNIMVLQDNRAVLVDFDWAAKQGEGRYPSMLSRAIIWPQGVKEYGRMEKEHDVYMLNALRQFCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWH6</accession>
    <name>A0A8H5LWH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWH6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="668" mass="76459" checksum="D430FDADAE22B54F" modified="2022-01-19" version="1">MNNCPEPSLQSTLDTSSVMRLLNTKNFTVKQFFTDIPCYVILSHTWEQDEVSFQDIKNLDVARSKAGWRKVMNACARARRYDFDWIWIDSCCINKESSAELSEALNSMYQYYEDATMCYVYLSDVSGEYHPRNAKSNFRDSRWFRRGWTLQELLAPEYVVFLDKGWERIGTRWSLRDVVSEVTGIPVDVFEGRIIDEYSVAQRMSWAVFRETTRLEDQAYCLLGVFGVSMSPIYGEGGVKAFMRLQQEIIRISDDRSIFAWAVALAGKAKTRGLLARSPYEFRMSGDVQASNVEFIGNKSSYSFNNNGLHIHLPFNPIPSSSEHFGEPIFLAHLLCQSMRGGSNLTVYLQNTSGHQYVQCYPDEIFLTSSLPPTLGDVRELTVTEHLVTACRVRASNTFRRSSQYKIEFLRSARDFFPFNKISSIDEHTVSLPSRVEEVYYLSQKTGDYFQITCRNDRPFLSIGLSSIEGYILGDTDLGELDSGNYIMITSERRGDSQEKIDIGYFAKDDPEIRLWTGLLGLPDLGVIVDPMMSSADSDFHDYHLELQGIFPPDPFGRSTQDMAYATVFRPHPDDPKECSHPTFRLLTYRLDLQLTSFVLPGRYMIHVAFGLQGSSVWTDIVVQNSPYHHTSEYVWKSYLDSGPRTGKRVCRGRVYGQFRSFTVFGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWK8</accession>
    <name>A0A8H5LWK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWK8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223082" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39621" checksum="00E10A7461729FDB" modified="2022-01-19" version="1">MLFQVLSSLLLALTAGASSLSQVDAPAPFNSSLFKDLNVSRGLNYHYYAVPADTGKPTLLFLHGFPSTSYDWRHQVAFFQEKGYGLLVPDLLGYGGTSKPLDPQLYVSSLVTRDIVDILDSESIDQAVVVAHDWGSKTASRLAHYFPERFLSYAFLAVGYVPPTFFATPYEERLNLSEAVLGYKNLGYWDFFSSEGADQTILNHLDSLWDILYPNDTTRTITDWSPLGALEAFITNDTRIAPVDYVTPEERAIQIEAIRQGGLAAPLNWYKIVRGTLEGEDDQGISPENALIHRPVFFGAALRDYISVAPIFVAGALVSSNSTVTIREYNSGHWVQMAFPDEVNSDLLQWIEGLGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWT6</accession>
    <name>A0A8H5LWT6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWT6"/>
    <dbReference type="OrthoDB" id="2800708at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="629" mass="70302" checksum="330A81AD2C345417" modified="2022-01-19" version="1">MENRRTAGLLAALSEKDKEITDLKLALKAHTVRTSNVQTRLLATLDALDTLQTSNTQDLAEANRKYRQLKEKMHKYRIFVQECESERDEMREAVNTLVEKVEASNNYALWSHARMQISSHVAIFASSDPVAASASPNLRNDPDRNLLEYAGAVIQALTLERDLEKQEHQHNLRVANARIAILESQLALRECELESCVSHTHECFDSQSFQELETQLASLSREDAIRLLQLASAKNGALDMGNKHMLKRLDIFRTHTSSKVDASCQTTEPKDFSQEKETDATRSPATIVGDVSTPFNFDIESGVKTPVPHSRGPSSFIEDFDREIRELGSKIEAFRAEQTKLVEITRTEKLDQPKPRGYSVRDLVIPPGHDSSRNPSPEPLISPREPKDTSEFPAEQPEPDMPIRELLEQAYKASLQREKSLIEENAKLFNLLRQTEDGQAVDVEKTNDQPRDPESSNVKTDDAAQPPAQHPEIPSVQLLDDDGEMTMDLGTPLLPTPIVLRNETPFPTVSTSSSNSPSQSSERHHDDSPQNANPINPVPHPHPAARQSYSPLPMSPPDSGYPDVDFSFQNNFALSPRVGQEPISEVDIDIDRLESELEEAQKRLADGENAMSDVQDALSILRIDSEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWX0</accession>
    <name>A0A8H5LWX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWX0"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="824" mass="89732" checksum="6A2CF6CA8018FFC5" modified="2022-01-19" version="1">MFAAATSFFARTAISQSYNIGGSSSNSGSRSSTPGPAQSPGPSNSTFSGSFTPTVPIGLWKVQSASHKVTNKRVSVWSFDKRSQEMERLGPMAKDRTLEVLKAEASALGRLRHPSILEMVEPLEETRNELIFATEPILASLELAIPSSGRFASLVELDEVEIQKGILQICKGLSFLHSSAQLIHSNICPESIIVNSSGDWKISGLGLTIPLLQPNGTATRWEFPTFDGRVPAYIQRSFDYMAPEYALDEQLVTASDMYSLGCVMYAVHCKGSPPFKTHDSLGGLRECAGRPVPGMDRLDPDLQSLLRALITRHHAGRPTPTLLPSQPFFSSLPISTLSFLDRSTFTAKTREEKISFMKGLAGVLDKFSDGLKTRKILPSLLEEMKDTHLLPYILPNVFAISSALSATQFASLVLPSLKPLFVLKEPPANMLTLLDNLTMLQSKTERGVFRTEVLPLVYNALESEHGMVQERALKTIPDLCDTIDYAEVRDVTYQRVANVFSSTRILTVKVATLATFLSMVKVLDQSTLTQKLVPMLANIRTKQPAVMMATLSVHEAMGAKVDREAVATLVLPQLWAMSMGPLLNVTQFQRFMAVIRQLADRVEKEHNQFLRDSQRIEDMSATAMIGSSSTQAITGSVDFENLVGRGAASSSNTQAPSLEDDPWGSIFNDTNAKPTKLPNPIASPVMASSPPLQAQSLPSSPKPSSHYQPSRLNPSTQSTSFTNSPVQRSNTGFSSVPTLQPTNLATTFQPAIQQQKPNYNISLPTSPPSNGFPPVLGSTSINSLPLMPPMMGNMLTPSKPSQPSWGSSSSKPSKDDWGDFDPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXI9</accession>
    <name>A0A8H5LXI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXI9"/>
    <dbReference type="OrthoDB" id="3259206at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18188" checksum="447342D28B363901" modified="2022-01-19" version="1">MSSTTLQGQQQSLPLSSSDLEILKEWMLQISVSWVLCGINVTLVLTILCAIFLSEQKRLSKPQLILFALVALMFIVTIGSAVLNTQFILLDMTTSGYNVPNIAEIEQQTVDLEIASLILDRLNYVIGDGIVIWRAWILFPGNRLVKAILTMAIIASFVGAGTDAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXN7</accession>
    <name>A0A8H5LXN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXN7"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000005">
        <property type="entry name" value="Cytochrome c oxidase assembly protein subunit 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5373149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9348" checksum="12570CD88D48A43A" modified="2022-01-19" version="1">MFDKVTSWWSSTGSNSASEEKYDPTNPKMNPLNPQGLKPCCACPQTKSARDDCFLKYGPEADEKCKELVQNHITCMRNLGFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXR9</accession>
    <name>A0A8H5LXR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-bundling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXR9"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5373955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32018" checksum="1CF222C95FE6CF93" modified="2022-01-19" version="1">MSADKVRSTKLKFKGEKTKKKRKREAADDAGPSRSKRKEDDLDPETWVLPENPMEIRGPTFIFHPSDPSPISLNFNSTTNRAVLHALDKDKSEDDEEITLLDRTPTDVAQVWVTTRVAGSPTINLRSGTGEGKFLSCDAHGIVSADRDARGPQEEWTPVILPDGMVALMNIYEKYLSVDEVAGGSLQLRGDSENVGFGERFWVKVQNKYKKEAHEEEKKKNLKEGDSLDSKIDEAGTNRVYQAWGAGRSLVSAEDKKDLKRARKEGRLQEALLDRRAKLKSDRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY56</accession>
    <name>A0A8H5LY56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY56"/>
    <dbReference type="OrthoDB" id="3264586at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="24362" checksum="E5F235DB41E57027" modified="2022-01-19" version="1">MAKTPNKSSLATRKGAASRSRKTPVTFADENTDSEEMRNEEKADEQSEDEDMNVNKLLQEIQKRQAKKTSLVSAAFENQKKALYANARQKAKDMSQDGTVYLEKLKHSILSMRESEVSYDRHLQEFRGLWDAQDAAATKLFGLYPPIIDDLFVRRAETIDEASKMLKLNPAKRQKALNQFLCNAHDQVEQSHQNKMVATDASKLIKHYKALLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZD8</accession>
    <name>A0A8H5LZD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZD8"/>
    <dbReference type="OrthoDB" id="5390558at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="106"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="34247" checksum="A87D186BA3356DC9" modified="2022-01-19" version="1">MSVASRNPFALLDEAADSRPASPPPKAPAAPAPASTRGTNQKSRGGPASRGGKYYARGGAKSTQARDGPTDDSAEPAPRKFDGERGRGRGRGGRGGRGGGGGERGGRRQFDRHSATGKTDSDKKVHQGWGGDDGNRELQDETTANVDAAAEAATPADAWGAEGATSADAWGTDGAAADGSAPAADAKPDGRPPRREEEEDNTLTLDQYLAQKKEKDLAAVPKLEARKANEGATGNWKDVVPLQKGEEDAYFVGKGKSAPKARAKKEEKVFIEIDAHFERPSRGGGRGRGGDRGRGGGGRGGRGGAGRGRPNGNNNSAPTVNVDDETAFPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AV73</accession>
    <name>A0A8H5AV73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000540">
        <property type="protein sequence ID" value="KAF5311559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AV73"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5311559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121194" checksum="698434001D17FBA7" modified="2022-01-19" version="1">MSLSSGSLSIFYMTSVVLDGMQHFSFASSHTPAKRLVLIVVDDLGPDFLFNPKSFPDRPRPQDDEHSDIIAPYLRSVIQFRGAFGVSRTVAPNEGLGLATIITGTAVPFVRKGWVDEPVDSLLGRAHRTYAFGTSTILSMFAGSTPEGKVKEWRRWKTEDFAEGIDASVLDWAAFEEMKMLFTNATSDPKLNAELTEDKTLILLTLRGLNTTAALDEATVTKNIMVMDKIVQETESLVRNFYNEKEGEEETTYIFTASCGTSPKNYWDGRKDDTRTPLVMWGKGVRGPQSAIADDIHSSQWGLEGLLRRDILQSDLSPLIATLLGTEWPAHSIGTLPGIVHHSNSYQEPDKLENVENGFVLFDEEDIARAAEVNAKVMLEQLRVQEAISRFRKAFALMSFSPVTLPMFTSYLTDVNTLIRQRHFTQARKKASVLIQLVSESIRHVETFNETVSQVEANLLHVVPQTRPLNIVQRLINRSMKTKLTEKAARWALASAIFAAISLMVWLQQASWKYVASVTWPFCFWVEVAEVFVACLLSSGLRAQGPIETLDMIEDVLQPATKQRKDDEFREQLHHVINWISGQVALIEERKVREERWEQNLEYLRESIYPVEGGDMIHAIHEKLDERQRIQDEISKEKSQKRTEKAAYVMQTRETVGELYKSFQEFLERWEDDVRRYRDKGKGREEADGGAIVNELTRQNQELRELLQSVSDGECHVSATIWLLVVITGPNPVPAWREDCERHHIDTINAVRETAHEQVPFNIQGYLDEFSKALASEVRMLLGEVGKLREERHGLLHEIGYLFCVRSKYRPGGEFEPDWKPTPGMPGGPPAEGPSTPEILQAFPGWRHVTQRTKKKKKEAAPQPPRPGEPMHGVPLPPGMDPRRQVQSWATWQPDPGLRPTPSSVEPILLVPDRGSPGLFGPRTPHGLVHTPPAVEPNPLVPDTEKQEWMPSSFPRKEDPKSEKPTVPLPQSSEPKLAKSGWVHVSRRRNRTKKSSLPPHPPPPPPPGTLDAKRLQKETGVDPIARSQGASWAAWQPDPGLQPSVDPTILVPAGLFGPRSPELAPNPKPSGSRDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRH8</accession>
    <name>A0A8H5BRH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000373">
        <property type="protein sequence ID" value="KAF5328020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRH8"/>
    <dbReference type="OrthoDB" id="3226942at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5328020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35350" checksum="40D7AA8947B2EABC" modified="2022-01-19" version="1">MGKTGVPTQELSTLGLLPANKSSATKEGSQMLKKRKSTGLDRYVDHGMTKEAIQDAHVKLFRYLVHGHAPFSCPENPFFHAFCDSIRPSYLVLTAYVLTHTVMDGEYAQVHLAECDWLKEHKMHTILHDGWEDKAGHALGGTVAANNKAPPVVLRLEDMTADRASADRHCQSIKLGIQKMELNVKTIIAITTDNPTVMQSAWNKLETEYHWILMFPCFLHRLNGIIGKIVSYQSMKRILSGTTHIVSYFNSLHYWGGQLTNEAKHLDIKRGLQTKTDSRWYSLSKQGLSVEEHRLLSMFAFIWTLRKRQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYB1</accession>
    <name>A0A8H5BYB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000317">
        <property type="protein sequence ID" value="KAF5331802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYB1"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5331802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31446" checksum="1F8686E44FB5C3A2" modified="2022-01-19" version="1">MAIANNLQSLQSLKSFHTNNLSGRVALVTGGGTGVGLTIARGFVANGAKVYITGRREDVLKQAAEQTVGLIPLKMDIRDKESIAHAAGILEREEGKLDVLVNNAGIVTPVSPFLSDKSTPKNSRLGLSLFQSESSEDWQNAFATNTIAPFFTTTGFSDLLEKGARMRGDHATSSVINISSAAGSFHSSLNAIAYGTTKAGLDHLTGTLAREFAIHKVPVRVNGIAPGPFPSEITGIPEEIDRQIKEGTFFCGTVLPPIERSGREEEITSAVVWLASDGGAFTNGVTLRIDGGLALVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C093</accession>
    <name>A0A8H5C093_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000320">
        <property type="protein sequence ID" value="KAF5331763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C093"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5331763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="270" mass="30531" checksum="711CDF63089037A7" modified="2022-01-19" version="1">MDISRLWSNLKLGLPSYSSFHSRLEQPVRLCLLRSKSRPLSVNLGSYVSDDTGPLVRPLVEESARWQHAQIGGLLEAKFPSLISGKSFPLLETLEVRHYRAGDGLPDLFLFNSAPQLHSLKNYQAPSPDKLRAFTPRNQISNFEMICGPSIYNGELYNFPSLKSMVYAEVDHSFVPEPDEILWQTLPHLSMVEFQMSNYEAGYDILEAFAQTPNRQTHSSISDQLGYQKFLRRGGRVGYRRGTNVQTQLAIPDICRFFPALVVLIIGSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C117</accession>
    <name>A0A8H5C117_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017208</name>
        <name evidence="7" type="ORF">D9758_017499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000302">
        <property type="protein sequence ID" value="KAF5332888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000294">
        <property type="protein sequence ID" value="KAF5332991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C117"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035101618" description="Casein kinase II subunit beta" evidence="5">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5332888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5332991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="286" mass="32138" checksum="96C04091501798D2" modified="2022-01-19" version="1">MHERMRALTTVLLLQWISWFLSSKGNEYFCEVDEDFILDRFNLTGLNNEVANYPQALDLITDQLDDDIQDEFRGSLDVQARLLYGLIHARWIVTARGLAKMLEKYKRAEFGRCPRVLCQQQPLLPVGLTDIPYEKSVKLYCGRCEDLYSPKSSRHGSIDGAYFGTTFPHLLFLVYPTLIPPKSGPADLGPLASNSGASGSGATGNGAAGGEITRTRTRRQKEEAPMIVEGGGENINTASVALKADRYRPKIYGFPVHEIAKLQRWQEAVRDRQVRRLEELEEQGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6Z0</accession>
    <name>A0A8H5C6Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000236">
        <property type="protein sequence ID" value="KAF5335844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6Z0"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="88"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="231" mass="24977" checksum="EB692F9401BCAADB" modified="2022-01-19" version="1">MLAACYISYVRDTRDPRVVYKDKLTTAFLAVHIHAYLFAYPLSSSLSLSLLLIVPLSAMQFTLSLASFAILFASSVSALPRTLEARQSLQDQAIDLHNTNRAKFGAGPVTWNGDIAAGVQDYANKCVFQHSGTNGVGENLAAGSGDFTMQNAMDSWMNEASKYDFNNPGFSEDTGHFTQVVWKGTNQIACAIADCAAGTIFPDLASKYVVCQYTPPGNVLGQFPDNVGRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7U6</accession>
    <name>A0A8H5C7U6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_015074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000224">
        <property type="protein sequence ID" value="KAF5336710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7U6"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="11">
        <location>
            <begin position="213"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5336710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="701" mass="74545" checksum="CE43166F22A29DC0" modified="2022-01-19" version="1">MASQLSQQYAFRAQKSLGLVGGTPDYIPVPGFENPDIPARFYSYSADGRLYAYALPSVVRIFQAEGAQLLHELPLPNVIELTFSPRGTYLSTWERPVKLEDGSQHKNLRVFSTSTGEELIALTQKSQEGWDLQYTISESHAVRLAGGEIQVFRPAEWNKGVVDKLKVEGATTVSLSPGLNPSIAVFVAEKKGAPASIKVYGLLALNGTPTCQKTFFKADRGQIKWNTLGTQVLLLTQTDVDNSNKSYYGETMLYLLSAAGNFDCRVTLDKDGPIHDFAWSPNSKEFGVVYGFMPAKAMIFDQRVRTIHDFGSAPNNFISFNPQARLVALAGFGNLAGKIDIFDRRALTKLTTIDAPNTSYCTWSPDGRFLMTSTLSPRLRVDNGIKIWHCTGPLVHIHTVDELYQVSWRPINVDNTPPFPTSGPVAIAPAPSPAVVAMEAAAALKRGAQTTGAAAKPAGAYRPPGARGGATPAIYKREDEGGLSRTPSGQNTPARGYNRSPAPPGSAAYGNGQQQGGQGRGGRFVPGAAGPSPHRPGGPRGDSGEGKANGANGQQGQGQGQGQGQGQGQGGRKRNKGAKKGEKGEKGGERPSSIDLTGVNGSGNPKQNGKMSPGPASGDTTPAIVMPAPVPADIASPVTPGVDGSLDPIAKKVRNLNKKLKAIEELKEKAKRGERLEATQLKKMEGETEIKKELTALEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C919</accession>
    <name>A0A8H5C919_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_013595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000217">
        <property type="protein sequence ID" value="KAF5337500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C919"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5337500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57459" checksum="7E1505264A07AA69" modified="2022-01-19" version="1">MLRTPWRALTSDTYISILETHVSFIISPMPSFLTSVDLTVAVALLFLSYVLHQRWKHKGFAKPPGPPGYPIIGNLLDIPNAKEMSDEIWAAWAKKWGDILSISVFGTTVVVINTFEEAVEMLDKRGAAFSDRPFLPMPMEVSDMKDIIGLSPYGKALTSRRALFHQELGTETALRAFQPELERLGKKFLHRLFTSPEKALYHCHHYTGSIILSIAYGYEIQETSPGQKDPLVEIVSKALENFNHASIPGAFLVNDIPFLLKLPEWLPGMGWRKLGRLWAKEYWDMVNVPYAYVKREMEKGTARVSFTSKWGVETTATALYAFLILMATHPDLQQRAQAEIQDVVGADRLPTFEDLKELPYLYAIFKEVIRCHPVAPGGLPHSNTHDKVYNGMFIPKGSIIFVNICPLDFLESILNRIREKRSLDLGEESVQVCAVKHVSRFWHVNGKVSLPGRRLVESTLCITFALVLTAFNISCDPDAPVKLKRNPGIISHLDEMKMKITPRLDRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCH9</accession>
    <name>A0A8H5CCH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCH9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5339287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="12230" checksum="12684A4719213B81" modified="2022-01-19" version="1">MLTEIAVTLYDSVAFYKHRAEGEINSTFAYIPEDVRTDAFRRARETLWALDVAWTRKPELRHVINFLRYIGGSIHMDDEAISLRRRGFDNWEARDGRCHRPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDY4</accession>
    <name>A0A8H5CDY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000185">
        <property type="protein sequence ID" value="KAF5339474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDY4"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5339474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="812" mass="91170" checksum="1962F81C4C62C9FA" modified="2022-01-19" version="1">MSGNRCTHCISLEIDCTHVLASIKKKRGPPFGKPRGSKSIRSTVSQILSTTKPFEVPDTPEAVLKLFKDLATYVRKLEEELDELQQRIPALPGWSQQNVLSDETAEQDARSLEGLSEQLKRLVLSQSFKRHFGTSSSLTLVRHAMDDVHLPQDIHWPSSHAARYLKARRPEFWAVYQWQIPPQEDLKPLAFPETDLMKKLIDLYFVNHGQYLPILHRPTFDRSVAEDMHLRNRNFGCVLLGVCALGSRYCDDPAVLEPEAPEFSAGWKYFRQIRPIPITYSAAPSLYQLQTICISIFFLEATSTPESVWVQVAVGIRLAQEVGAHRRRQGQKPTIEGELWKRVFWMLYSCDIYVSASLGRPRATSSDDFDIDLPVQCDDEYWEHPDPELAFKQPPGRPSKLVYLITFLRLLDILNIAQKTIYLTRRSDTWSMMGRSDLEWSQRTVSELDSMLNNWIGTIPEHLKWDPNREDTVFFHQSVSLYVSYYWIQILVHKPFIPRLGATSEITFPSMAICANAARSACHVMEVQQRHGSLPLVNVVLTLYNAAIVLLLNAWRGKHLRTTPGTNNELVDVYKCIGMLRSYEGRWQRAGTYCDIIREILAISNLYSPEPSDTGCLKRYRDSKDDSSTGGQQPTSSPNSNSSSSSSSLPSSSGSGEPRKIAGTHRVSALASRQSSGNGTSHGTTTTLNIDPIFNLPLRSNELGSLPLHESFDPFGDAQTFVNSSIWMAELFQTDSEESQVPVTGTGGGDGRIFCAEPSIQSLNLPSQQMGQTIFVDSGSSAIDSNPTTMSSSDWDAYIANVDDLLRSFMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGM1</accession>
    <name>A0A8H5CGM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGM1"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034286952" evidence="7">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5340914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="331" mass="35469" checksum="C49214C770D05702" modified="2022-01-19" version="1">MPPKPVLLLLCLALFAGLFANANKSNLSAISVTDEDIQQCPSVQQLSSLKLGMEEGESPIMRKIFAWLFPFGPAWNSILGTFYISSVPNFILAFIPAQINGDTLNTMTAFATGGLLSDVFLHLVPHSFMGEHQGEGVHFVMVEEKRNILVGLGIFLGFAAFFFMEKSLRVLGGGEEGEGHSHGHSHSHSNSNSAAESSVAESTGVSLSSQNQQLKSRSKSTGDSSSEVKCDVTTTPVNASSKLSAYLNLFGDFVHNITDGLAMAASFYASPLIGATTTLACFAHEIPHEIADYSILIRSGFTKKQAMQSQFITAVGAFVSCFPHEVRDAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM07</accession>
    <name>A0A8H5CM07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM07"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="77" mass="8339" checksum="5FA25B9324B27A4D" modified="2022-01-19" version="1">MSLPTVNFSGYTVKWATGGLPTYVRYPTLASIGEADSVEGFEERPELIEATSAESPRSSQEGQNKLFLFVGLGIPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMV7</accession>
    <name>A0A8H5CMV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMV7"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="22902" checksum="CADBF2B4FD659DA2" modified="2022-01-19" version="1">MLIAELDTLYNNFPTAVLYLQEMLHDWESTPKSWKVQLVWDHLHQRIVSQCAHYTTILPAGINSYLSIWVHDNHQSYNSCSSNSHTSSLSFCGAHSNPAAAAIAGAVKPKTHCQQQLTITEFAVWANDMGLHPDEVLPAPEAVLCEFAASFLGRLAGGTVKAKLSALKTWHTTLGFRWQGADLLCKTLTGVNRQSPSSSHHPECPPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNF1</accession>
    <name>A0A8H5CNF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNF1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5345017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19538" checksum="62ACCF4107F0F2D1" modified="2022-01-19" version="1">MQFFLIDLDAYLLNVSVIPPLIGVIVLEVLPVNNSRGRLAGIMVLYTYWSPYILGQAIMLSNTAGLTKKTAVYAVNYIGYSVGNLIGPQIFLTKEAPGYGTAIRTMLVCYSVDAVLFLVYGLWCNHLNSRKAAQRAQLESEQRSGDEDSKPGVARVMDDDALADLTDLQNPHFIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP11</accession>
    <name>A0A8H5CP11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP11"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034554152" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="471"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5345347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="681" mass="75307" checksum="3C6915F5B11CA8BD" modified="2022-01-19" version="1">MRRSNLGKFLLLCCIFSPVAPEIVAPNALELRITTNVTHEIPSTLFGYMWEDINHRSGFNIGKTRPSLLLTVKTTAPMAVSTNRAFQGVIPGTQNALYAWQSYNGARLSVTSKTEGVSDALPNSLEVKIPKAVSGPIGFENTGYWGIKVQEGWAYKGSLYAKSDSYNGPITVSLKSARGTTFASQTLQGISNSWKKFTFEFEPKVSAPNDNNVFSVVLDGKATAGKTLHFGMFSLFPPTFKGRENGMRIDLAQLFVDTDPGVFRFGGNNVEGSSWDGRWKWNETIGRLEDRPGRIGDWNYPNTDGVGLMEYLNWAEDIGAELILGIWAGISIQNYSDFATWPVVPEADLQPYVDDVLNEIEFIVGDTSTQWGSVRASLGREEPYALRLIEIGNEDNFQADSYAAYRWQAFVDAISAKFPQMEFIATTLPSTALNPPYKRIDFHQYNSPSWFKANAFFFDSYPRNQTKWFIGEYAVTSTNDSNALGTLDQGRLQYPTLLGSVAEAAFMTGLERNSDVVFAAAYAPSFQNIHEFQWTPDIVTFDASRLARSTSYYMFSVNKGTHSLATSPTPSNDTAPLFWSASYNNESDVVFLKVANTGEQDLVANIFLDFPSTGHIHAVTLATPPLTAVFGQFNTSNTLEEPDLIIPVPFSAAIPILDKFNYTFPATSVTVLTVQSPKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP70</accession>
    <name>A0A8H5CP70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002139</name>
        <name evidence="2" type="ORF">D9758_008517</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP70"/>
    <dbReference type="OrthoDB" id="3257486at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="23971" checksum="D8B8BD2EB7CD0FEA" modified="2022-01-19" version="1">MSAITRNKQIPSITLKTELIGKITGRKIDASALIDSGAEGIIINSQFAQRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDNKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSESRVDMTRCPKTCITAKPPVLHLKTKTLKPTVIDPRTHHKEYQEDVVEFLFDPSTEIQKKRQSLPKTTTGEIRSQNGGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR37</accession>
    <name>A0A8H5CR37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_011475</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR37"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5346340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="130" mass="14515" checksum="202E113FD106DD0F" modified="2022-01-19" version="1">MDTFGSLTRIIVWLNCPATVVHNTLRQRTHIMASGFGFGGGGRPRCFAYWQEFSKCYAQADIPQECRAQADDYLECLHHTKEAARAKRIEEEFVRQARAKAKEDRKAAEILSDGVIVGVGLIQRGGEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRJ3</accession>
    <name>A0A8H5CRJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cornichon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRJ3"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5345337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15863" checksum="56313C311352D80E" modified="2022-01-19" version="1">MGSAGWLFLFAVLMAAALLFCMVFFIIMFSDLECDYINPIDLCNKLNQFVLPENIAHAFLTVLFLISGQWIAFLLNAPLLVFNANKIRNHNHMYDATEIFRTLPGHKKESFIKLGFYLLSFFYYLYRMIVALIAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT03</accession>
    <name>A0A8H5CT03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CT03"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="336" mass="36552" checksum="BAC0FC500E1F6C5D" modified="2022-01-19" version="1">MGNVESHAIYTEGIRRDEDALDITVEKDGSADNSVPVASIGTTSVPIVSAVVNGESTFKKFYENNPESESLMPILLQQIIDDGASDISSKSSLAETASSYSDCGFGLQPDSDNNNEELHHSYARISTLVINKVPFNTLPSTFSPYASRMPINRTLIAPDVHDAEESCPPSALCSSPYSSVVLVAEYAEEERDTREVESLLLPSPAAVSPFPNGSTAAAASANAHNAGVSGPYGDPNRVQVPHFNHKTESESESSEFSWLLEYVDTPSPPRLNSPVPLAHDLCVTRSQLSMAQADLASECLHYRNLQDVMELKRAEGARVIQEQERLVESLRRELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUK4</accession>
    <name>A0A8H5CUK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydantoinase/oxoprolinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000087">
        <property type="protein sequence ID" value="KAF5348200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUK4"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="152" mass="16523" checksum="1E41DFAE0D0D57C8" modified="2022-01-19" version="1">MIVRSPNSPAIKQTPQHLHSSGYRSLAIVFAHFYTYPQHERLVMSIAREVGLTQVSQSANLVPMTKLVPRGPGCTADAYLNPILHQYLNDLLSGFDAHSCKGSRSSTSSASSSSGSKSTGRGDKREKEGTRKPRVEFMSPSEAWSTQTNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXL3</accession>
    <name>A0A8H5CXL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXL3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="683" mass="71953" checksum="CC66BF53E706368A" modified="2022-01-19" version="1">MVSKRFEALSGSSPQVLQRRQDSILVFSSNGQAGLLQGVESVPSSQGQYVQTALVTAGVQTAAVPQAPFGVPTSVPQSISQPTITSLSSVPTRTIFAAASLSLPSQTSSSSIPASTQLTASSASISTSTNPSSDTATSSSQSSTSYTSSTSEMPFPTRTVPFSSSSPTSTSVTSGSGFQALIHSQPVYASGIALLTLIVLAFLTATTAYVFRCLRRRKLKRNRLSLEELIIEETNRDRDNNFGYDHDPEVASVSENRASHLQLQFPTDPEFGTPRAGIANPRFLGLGDGLEVPWEPRSSDGPTGSLNASEAHIATSTEKGDLSLPRALPLAPPPATLPRRGTLSRASSDSSQSSGYVPSSNPFRDPSSSGYPYAYSVKSLPSPSAASSQKSSAKGMWAFGFGSALSLASTSVIPAADPLASSNNVIPSSIPSRAAEPLDDSNKGWSASLKAGFFNAFSALRGGGDSVSGAQQMMEEGQSDTYTKIVSRKTSRKSTRTSWAISQPPCDDDEVKPRKEGEAVEYWGGELVGLPSQTEKTASPAPLDMGFLEVGDLGMGLGLDPHSIHGYSESPVDMDGRWTASPISLASATPLIIKKKSLGREGVEKSLGEMSRQSSQATCRGGGGQGVSRKGTMRSMVSSSSTRRSRVSRANSIMTVLDEKEEEAGRALRERWARNLKQSSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D004</accession>
    <name>A0A8H5D004_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D004"/>
    <dbReference type="OrthoDB" id="2788977at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="24655" checksum="D7F645517E668ACA" modified="2022-01-19" version="1">MIPSSLVHRHQHAQDSSAEGSSKISPSETTTSIASSKLEIALKKMSKKASMYEYEMKELEAKLSESLGNFRAIDSVIQETLNGLRHNGKQADKALHVQIPFITRQLDESSEILSQLSRSLPKIQSEVSSIRSVYDSGREKAQSLVVDLSWLNTEFYERWRVIIFTSSSPVSLRWKAIMRVLFTISFVICCWLAWIALFGLYRAYRHKLVWGERLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5H8</accession>
    <name>A0A8H5D5H8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5H8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="98" mass="10810" checksum="52A527747C7603D3" modified="2022-01-19" version="1">MSDTMNAKQDAREDDYNPDLEDSYPGPLAAFPYYHPSPLSLYPLSEPILVPGYAAYSSLLSLMPYIPIVQIDPSSSRLPILHAAQALALCVLHNHLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5Y1</accession>
    <name>A0A8H5D5Y1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5Y1"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23316" checksum="2E988052094B3D25" modified="2022-01-19" version="1">MTTIEDRARESDNYNNSFLVPADPVLDAALKNASDKGLPVDDGVSKAQGKFLYLLAKTLNAKRILEVGTLGGYSTIWLGRALPEDGELYTLEVSKEHAKVAEENLSVAGLSAKCKVIVGPAYNSMLDMKPEVPYDLIFIDADKPSNTKYFTEAKRLVRAGGVIIVDNVIQFPDHVEEILQALRNDKDLEAVTMGTIGEKGYDGFIYARKRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6F8</accession>
    <name>A0A8H5D6F8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6F8"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22862" checksum="67936CE0369978B2" modified="2022-01-19" version="1">MSAITRNKQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFAQRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIHSRDNKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKTLKPIVIDPRTHHKEYQVRWIEPVGRFKPTAQPKIAGRRRRIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6H1</accession>
    <name>A0A8H5D6H1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6H1"/>
    <dbReference type="OrthoDB" id="3229088at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19092" checksum="A2ECC661739F16A5" modified="2022-01-19" version="1">MATSHAKPNLAPSHTLSSPRPDITPAVSVAIPLDVKTDQLALISDVSTPCTSQDRKLPPEIWQEIFLLCTGHSEQAFNDAMFDHTAEEPLDVSTIITSNPADALKDTPWAVSQVCGHWRAVACSTPHLWTWVHVDLQRPRLHLHRKRIDFIRQVWSTEAANLPELHFRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7B5</accession>
    <name>A0A8H5D7B5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7B5"/>
    <dbReference type="OrthoDB" id="2831360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5354489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="25133" checksum="D45F7DAEC6FE709F" modified="2022-01-19" version="1">MESRADIDPARSDRRTGVVRMRLLFQFAHTKESEFVDSKEHSCCNPEIRLVLVSCIVHEVLSRRCSRCKIILYCSERCRKHDWKFHNHRGLCDEAVNHVNSNSLSKTMPLIPGFSNGSSESQSVTGYRLRSNDSKRMIERVIQSPSLIFIFKLGSLRYPLEKENLERIKLEIHAGTFREWMMAYAIFPEGKQRFKVIVGQFELEDRQERAAGLLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D808</accession>
    <name>A0A8H5D808_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D808"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35945" checksum="40F9ABF6F11883CF" modified="2022-01-19" version="1">MSSVLSEGNSQERIVLILVGLIGSGKVVECPMLQPQLTCNTTQSSFATSLERHFPNFVRCNQDELGDRRRVEALARESLSEGLSVCIDRTNFNPSQRRYWIDIAHEFPGSQIWVIVFDTPYEVCAERLRQRTAHPTITSPEQGLSVLARFASDFQAPVAEEGFDRMISFHSSEHPRPEYSHSDVTSILQRLRDSPSISHTRSYRQYGSSSPRSRPWAHSRGRGRGSGRGYYNPRHSEYGHGSHYGEPARSAHLNKTREQTSTFSTRAQTRPWRSTVLGRRSVVTDVGIRNGESAIATPSIIHALTTVSPRSDGGFDAQSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EVM4</accession>
    <name>A0A8H5EVM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000507">
        <property type="protein sequence ID" value="KAF5314230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EVM4"/>
    <dbReference type="OrthoDB" id="3252135at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5314230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="446" mass="49082" checksum="1F932967FE74BD8B" modified="2022-01-19" version="1">MGSNHNMSFISTSTFSSRPSLDLILTRPPSYLSAPPSLNLPDYHPYPLPGEECIQASPLGRPRRTGTYQKKSGSVTLILTEQPENTSSPSYGNQGQVNGVIVLEKRDVVSEVYVKLEGEMNLVIPDQGAHTMVLFEEEQLLWKTSNQSNSTSTLEICPSQIPFSCRFPETFMSPMAQDQLLPLPPSLDVFYPGSLLTRIKYRLKIKVVQGRRRQSSAQSVLGFLGRLGLENFKILNVPIDYLPHTRPPYSVHHLICGPLSVPGFLSDLKRSPDEWVQSISSIKSSREDIAPCVDCHLFIPSIKIFSLADTIPFHIILTGPIRSLQEFVPSSCLPSPSPSARRNSSRSATAQKCSESVIYIYILRQICAKINNGESSAEGTGVRAVRNIIIGHGVVREVPPSIDDDLGRGDEGMLKWEGELSIITGSLTSNLGTFDAGGICLRILLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F080</accession>
    <name>A0A8H5F080_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000444">
        <property type="protein sequence ID" value="KAF5318899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F080"/>
    <dbReference type="OrthoDB" id="3057283at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5318899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68743" checksum="E29165172CE2284E" modified="2022-01-19" version="1">MMMVQEKRKNNQCHDLNSFFDLHHHTFDSKLPSTPVPLSPASICWSNTLITMICSSCGASKPYTNHFDITDASARVTQMLRIFPIPISSSSVVSQMQVDIESDMRHYDLEMSQLQSRLVYLQAKQELLSKHVEQLKSLSAPIRRLPVELLARIFVMVCEEDAITFSLHAQIAWRLPFVLASVCSGWRGVAVATSRLWSNLCTFWTTKPTAPRLEPPLKLCLLRSQNHPLSVELRIEPSEGPDDPTLQMLTEQCSRWKHVTVLNLVEENFPGLSNGRSFPLLETLEITHYDSESEHPDLHLFSSAPRLHTLKINKLPPPETLETFTPCAQITSLTVSCFYDFFEVLNKFSSLKSMIFADVDHSYIPEPEELPLQTLPYVTTVEFQLSDDERLSHECNLLKMFVEKLTLPSLTTLTIGTDAFHLATDMFKGVWPPQTFSDFFQRSGCSLTALHLDYISLPDRELIVLLRLNPSLVELRVKEIRRKDYDFAAVASSDGTIFKFEDIITPLLLTSLHAYNHGLALASPLVPKLERLHFVADGFLFDDELFWKMVMSRWIPEREYVLTIGVSCLKSVKIHVLNRGLQEDVERRLQQLERAGLRVSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8X3</accession>
    <name>A0A8H5F8X3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000368">
        <property type="protein sequence ID" value="KAF5328120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F8X3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5328120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="121" mass="13898" checksum="674EC1F6D7AE28D8" modified="2022-01-19" version="1">MRFYWVHVWNAQSVANALDVLNLAALFLKDNISILDGYPVDSSLRIPTSRRRSRSHQIEDTYSAVARLKRVQVLILCRYHCGWFRAPWYYPQKGLGGTAGLAEMGIGLERTWPQEYAAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FD50</accession>
    <name>A0A8H5FD50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FD50"/>
    <dbReference type="OrthoDB" id="3258470at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5332411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="140" mass="15475" checksum="B0B4124CD22AED81" modified="2022-01-19" version="1">MTIKSKAAIYVVARHMVGNTFPYTIQDWSDDISLASKHNIDGFAFNIGSDPWQPDRVADAYQAALQSGLDFKLFLSLGMSSLPCASPTDAQALRSLVLKLAGHPNQLRYSKTSLDPLPLVSTFSGGGVYVWTRFPFEWME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEP6</accession>
    <name>A0A8H5FEP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1541"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="569"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="592"/>
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        </location>
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            <begin position="1520"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF5334061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1559" mass="165051" checksum="157246526A0CD768" modified="2022-01-19" version="1">MAAKPLRPEPMNVTTNHPKVKLNLILASPLFVAGDYICGKMEMDCRADQGLGIGSMMVELFAFQELHSRDHSATSNFIHLRRFFQGPGLPPSNAVQAHPQPGDPPLPPQYYQARRGHSTFLFRLPLPHTSPSSISFGSDLATVRYEVRASVGVSWKGERRVVTEKKEVEVVEAFDERLMALTVPGREPEAVTVGENGKIWMQGRIIGGLIVAGETACVELQVKNHSNKKNTGLYVTITRVLDLPEAEVNDKAPPLELTDTLTTIPFKGAEYIIPPGAEGVASLVFDVPRSAKGVKGGILLGDVVENMPTDDSRKIKESESIFEIRCIVGVKMAMGLGSKDILVEIPVPVVHPAALPELPPIEEPQPYPNPYPAYPGQDPYYNPYPHPSHTPGPYPAHGHPHQHYAHLHSSTPGPYPAPPQSPQIYSNIPPDRVQSPYGQQAYPPLPMSPSLGPAAAAVNGAYVDPGTNMVWLPPPSGYDLNGYEHGDGGEYQGEYYVPPIPTFHNLHPQQPQGDPYGYDSHHQPQPPPHPQSPHAYASPSLPPPPIPPPRPSKPNPNPNPISPHLPLPGSTSVPGLPPASTTPGLSALGFGVDAGVGGGVGPSSPSRHDPHYDNYSPNPGHGYGGASVSRRPSGRARSVSPQRSPSRLQPQTQTHRQTQPQVSPQSSHTPSQPRPTTMSGSTSIPKLDLANLTPNPVDVFSSNDNANTSTTPYTHPDLGSGHGSLSPGSVGGVGAGAGAEYFGLGLETKEVSKSERVEELERIADEVGRKKKDLSRDVPRDSVLGLGESSKSTKDEKEEDKARASMNKTLPAPPVPTVNDKERFEWRKSGAGPSTRARVDAYFSNGANASAGVGNETLPPPPTLSRQDNDGDSTPPTPATPTLTAVRAKSKIKADMTPKDLLSPTSGALGRGFGKRESGLDALEAKLLAEVGTRKPPPEKKPDVWSILGPGQSQGRSSPSRTSGQSQSQSQSQSPGQRGQIQKISTPQTEKPSPISIPPMKRRDSDVDPSLNDSAISSLTLPDCGDVNDVKDVNELKKGMGGRGYDDDELAINVNGALKDYEEEREERDSDEKSQKTHKGRGSKTRSDTEGKSEKAGKKRHSREKGKVKAAAAKGKVTAWLGNVEADVPPDEDVIEPSPSPGIAAKERVEGLPSSSASNVLSGVGGGGGAKEEELSMEELLKKEQEEMDKANPPKPGQSSPNPRSSGFVPIGTLKRDIYQRSLVPKDSPFASTNNPVEDAKRITDLWSVTNNKTKGATPTLKTNKDVSPPSTPGKSGKDTAANNPWQSVRSPWFAGRRVSGGSKLPLYPPPVQDRQKYDIQSARGGKGGRVTAVAAIWASGAVAKEEDKKLDKVEGEVPKTKKLSLPNVISASSSSSSSSDVTGTGPSAGARPNGVSKRAGTGLGAGKRPAVRTASIPAPTIISSSHATPTLSTTASLAKPPGQMSPGKTQLANKVPLTTISELPSEGSKTKNRALFAGVGANRPSSSAEVKPAEVSGVNKGSAAAGLKALSGGDIKPTSAPSKRNSMPTSMTSPATGELAFGQARLRDLIKKYQGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8H5FGG4_9AGAR</name>
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        </submittedName>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000240">
        <property type="protein sequence ID" value="KAF5335578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="48"/>
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            <begin position="64"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF5335578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="54857" checksum="5672645343F0F481" modified="2022-01-19" version="1">MPSLLGVHRWNSDVVPRPSSPPAPLEVVINQPSPPHSLLLTRRSTSSSAPPPSPNITSPPFHPTQPSLPSVNSSHFASRRPRPENQIQPSSLRPHVLAKHRLQDWESPWSLEHRAKAKATYGDEVVQLAEAMAGVSVVESSFETYAAGPLRFTQFCDEYKVDEHLRMPADKVLVAAFIGFHLGQKSGSSLNNWLSGLKMWHDMKGAPWCGGERWVQMACRAGNREGAHLKRPLRSPVTYHHLQILRKYLYFSKPFHRAVWAVAVVCFLACRRLGELTIPSKSKFNSRFHASHATTFKQWLESDVPCLSFHLPWTKSTRELGAEVILTARLADPHGICGVQAIGLHYQLNGNIPDEYSMFGYFNDQGLPQHMVKTDFLTCCFDIWKREAMCDVLGHSFRIGGAVFHLLDGLAPEMVAKLGGWTSLAFLLYWRRINEIISKATVDVYKKQELEKVYASLEEFRERNGISRSTIQEALDGLANSSLHDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIF7</accession>
    <name>A0A8H5FIF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">D9758_019113</name>
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    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000208">
        <property type="protein sequence ID" value="KAF5337752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIF7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="33275" checksum="94CE3B2025928B1B" modified="2022-01-19" version="1">MSSNNAINNSESIFNVPILNTTNYEFWNYAITCLLEAKGLSRVASGTQKRYVNTSPTETGNAPSFPEGFVQVSDEVFNALTESEQSYYNQIIDTFAHEWDQYQILVNKQDRQLVETYKLHSSWDDKDEQALGFTSSYLPNDMGLKMREFTRDEIEEDPCAKAKGDYTAKMLWDKIDKKDSSPGPTSWFLDFKEFMSWVLDEKKDPANQIASLGAVLTHLKAYGFTVDDKFRALFLMDRILQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKQQTGQSSESSLLTCITGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJM3</accession>
    <name>A0A8H5FJM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000189">
        <property type="protein sequence ID" value="KAF5339027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJM3"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="19652" checksum="2FCB2ACA7BD25785" modified="2022-01-19" version="1">MKYHPRSPEEEEKTKNVMLKGHTDIGSVTILWSQPIGGLQILSPDGKWRWIKHIDNALVINAGDAMEFLCGGFYPPTRHRVIQPPSDQRHLPRLGTFYFAMADDDVKLVPHEESPVLQRVGIKRLCSNDEAPTMEHWRKGRTTAYGNSVLRPGKEINVEEENIHGVLVKHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL94</accession>
    <name>A0A8H5FL94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_012288</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL94"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034485182" evidence="13">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5341365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="38158" checksum="5372C36AFDFCC093" modified="2022-01-19" version="1">MMYTSPLISAVILAAAGLAAGHASIWHPSMYGFNVTDQTFPYDNRPVAPLVDMTFDQWWFHGHLDHPPNPGDIFDLPAGQTVTTEIACNKGATTHFNSSEGGDIRDPNNPNDVCPGAPIAEYHTSGFDDLTGCALAIAYKNDARDVKPEDFTVFSVNQTCVWTRFTDFEVPERMPPCPEGGCTCAWFWIHSPDSGGEQNYMNGFKCNITGSTSNVALAKPEVPRRCGSDPSFNGSFNRVKLNTAPANCTYGAKQPFYWFQKEGNNMFEDTYGPPIYTDLYNFLDGAQDDIFEDSYEELPDPSPVAALPVLANIGNILTGDKQSKQSQSSSASDSQSSSPHGVKGILGAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLZ5</accession>
    <name>A0A8H5FLZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLZ5"/>
    <dbReference type="OrthoDB" id="3122385at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034149544" evidence="2">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="21281" checksum="30A8B8463AF2987A" modified="2022-01-19" version="1">MKSSLSIKSFAILNAFLLVLTAADEITLFHVGDGAALPTATLTPVGTADGGSATTFVFINDQNEINFGGQTASVETQTIVASAGGWEMNVGGDNAIDIKCSSPDAQQNGSCDVKIGGDSGGIDSPATGSMVPEVFPVAGGGSGSGSGSSSTGSGSNGSSSSSPPTSTGNAGANPSASGSNSGSGSSNGSSGSNANGAGGLGMIDMRYVGLVIGSVVTGVLMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMR8</accession>
    <name>A0A8H5FMR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000153">
        <property type="protein sequence ID" value="KAF5342910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMR8"/>
    <dbReference type="OrthoDB" id="3027520at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="649"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5342910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1151" mass="130613" checksum="BE1CCF2672E983DD" modified="2022-01-19" version="1">MTQSRDNFLETCRQMVETENSGVFNQLVKIMQERWPGLEAWQRWWLAPEHASMIFRSQRTMDSTLASKLPDTTNAEESLHSVIYTIAGQNKDIVPGCDVGQPIRYGRSQRQRKLDRLAATTIPETPKRRRSSQSHTPSPRKRDRSALREGRAPDTQSDLRKSKKQKHVKILALSSSGSEDELPSSPKKAKKEQQIKIPVLDSFSSKHDKIPVSKKKMSQGKEKRPDLSAPLSIDLAITKEFASYPWSRNSCWLDTSLHLVYITLMCHGHWEEFASFAAPCAGQDPTKWPISYLHKTLSDRRAWPLSTFAGSHSEDDGSQKLQNIRDRFRHILAGLPRCLSGEETSYHIYWLYYLITAPNTKRCDGPICPDAEPAARDFNLFKGNIGNWFESLFNLSSLEVPQSFEECWRHHTREGTNDPDIYCQGSCQKMEFVSWIPSVLIIRPGVSEEGKQPDWDFPCAMYLDTKSSSKKSGAVYKLVGRMFSNGTHFRCITLIPTTGGKSVAFLYDGMEHNGYAQQLKGKIADLLGGKTSLSGYHTVCSFYSLEGGVNAQKKFHQDCIKTAREKLDIQLDGTNSATLVKAGYRVMKVEETKRWKPHYSVTEYQQTDSDQQVIQSISPHSNASSGCPVTPSRTILSSSPPPSSPLPILCQCGTENDGHRDSVKQDTVQCDQCQRWSHLACLVNRLEPTIEGAFICHVCSGQSLLASKRLEIRPPNCTQMLQDVANRLYAGRTVLLQMTARDKFYYPGRLLHGEKGKWTVKMWRGIKHENANKILEGIPISRIVDGLYGDREGRRAIRLGKFTRIHEERDPEDVATDWRAFPYNTEVDKALYKHKITLQEILLSTISSDFSELSVECVPALSLYLEDIDLGYTLPEGYIALTSMFGHPCPSYFTGGITTDDRARILNWIHENVAGIGKDFTAADFELCFAHARTLFLAHSQRETFLEHVKEGSSVQEIECLILQQAWQRLVDFTGKTVDGKDKIQRADVDGEALMILEAAMFDRSAKAGKAGREQWGLDVGPPEDSWWPYDGPEKYAPDIQHATESDLEEGEQCKVIREKIEAENKAKRIEEEKKAPPRPKPKPRFKEKILNSSKEALQKVGELNKGIATEPTEHHLPYQSTRSKRKLVAERENHETEDQHQYKRLRRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNJ3</accession>
    <name>A0A8H5FNJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_011152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNJ3"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5343047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58472" checksum="6731BB26254385DF" modified="2022-01-19" version="1">MFHFNVESLDFGHWKSLALFILVTLVVRIFYKPKRTLPPGPKGLPVLGNVFQLPKIQQFRRFTEWKEEFGPIFSLNLAGQTMIVLNSHKVTLDLFDRRSTIYSDRPRFIMAGEILTGGLVLPFCGYGDLLRRLRKAAHEGFNIRASEAYQPIQEKEATVLVHNLLQDPNSWDDQLKRSAASMVLMAVYGMESIKSKDDPLIARINDCMHRLTRAALPGSFLVDFLPIMKYLPEALAPWKKEGNEWYRKDTAMFQGFLDDVQSRVNAGQAKPTFAAGLLQERKSGQLSTPEASWLAAAMFLAGSETTAAALVVFILAMRLYPSVMKKAQAEIDAVVGRDRLPTFEDKDHLPYIQAIVKEVLRWRPIAPLGLPRRAMKIRSMVIGNIWAMNHDPTMFLDHDEFRPERFLGETGTVNITPTDSRNQGHVSFGFGRRICAGLNLANQTLFIDIASLLWAGSIEPAYDETGAEIIPSSMELLDEGIVVRPVPFKCNIVPRSEDVNAVLEEAKRKFGDDLRPVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNK8</accession>
    <name>A0A8H5FNK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNK8"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06222">
        <property type="entry name" value="RNase_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044730">
        <property type="entry name" value="RNase_H-like_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="305" mass="34425" checksum="638C8DD392CE3F92" modified="2022-01-19" version="1">MLWYEPYQKQYPAKQTRLLQLFDLLGIPHEEPKQEWGSSLVIIGFSFDPNAMTITLPPSSRLELITALRQFAQPGTRRPLRDFERLAGWSQWSFNVAPLLRPGLSHMYDKMAGKSEVFQLMWVSVALCRELLWMAERLEASDGVLLLDSLEWSTLDADLVLYTDASAAGMGIWCPSLHRGLHSLIDKPEPSRIFFYEVLAVVSALTFAASFNHFHRIVIFTDNLNTVSMFNSLHAKPDYNPLLITAMNTLLDNNLQLRVLHIPGSENVIADAISRSNFDIVASKHPESTLHIFSPPELSSGSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRE0</accession>
    <name>A0A8H5FRE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_011530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRE0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="172"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5346316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="608" mass="68514" checksum="B018A7B727F422D4" modified="2022-01-19" version="1">MSSDYELDSDEEYYDDEEMIDGTQDDASEDEMDMDDYNDDFRVDTGSKKKAYEIDYQSLTQSDVEKLMKQDIDHVVGITGVDESTAALLLRHSNWNKERLIEKYMDNLTTVVVEAGVTAPEPTSSPPSARTHSVSSACLPRGGSSSKPSSTASHSHPPPPSFQASSKSEEPEPFVCPICFDDSAELHPLSLDCGHLSCSGCWAAYITSKIRDEGEHAIRCMAEGCALVAPDPFIRNVLLPPEGSTSPPLDPKELKANQAAWNRFQELLARNFVASISSLKFCPYPGCTRTVKCPTAASKSSLTTIVPTVSCGSRGIPVSEDPKSQPSASLLKKEHKFCFGCTVESDHRPVVCGVAKMWLKKCEDDSETANWIKSNTKECSQCQSTIEKNGGCNHMTCKKCKHEFCWVCMGPWSEHGTQWYSCNRYDEKAGVDARDVQSQSRASLERYLHYYNRWANHEQSAKLSVDLYAKTEKKMEDMQLTSELTWIEVQFMKKAVEEAEKCRMTLKWTYAMAYYLAPGNEKELFEDNQRDLEKAVEDLSELLESSIEAEEIATLRQRVTDKTVYVQKRNDIVLDDTAKGFLEGRWRWNALLKALKRMLRLKRWPSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FS34</accession>
    <name>A0A8H5FS34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_011659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FS34"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="166"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5347069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="549" mass="62494" checksum="D3042C3A15636914" modified="2022-01-19" version="1">MTPLNALMDAQVKDLLDKGIQAVALNSSSKAEELFEEITMDPSQPPTRHLKHQVILTSPETALKSSFHEKLLKTDEFKSACVSVVVDEAHCIAEWGGDFRPHYDAVGKLLARCPSHVPVLIASATMPQDVRELIAEKLDLGENYDLVAVSNAKPNVGLSVRVIQHPIQTYADLLFLFPNDTNPEDFKQTLIYDFLRAHCPPTMSPDTIEFYHRNIGNRKTEVEEKLRSGYLKIVIATDALGMGMDFKNVLRVVLWLEPRSFLSFVQKVGRCARSPHDIGQAILFVTRASMARHVSDFDRDEASDDENGEDRAEIDEEIIDRAMDPVDREAVIDEDEPEYNSGSDAEPDPDLVVKRKRRKVKSAREARDLAYLTFIIATNRCQRLPWDEFFGNHAKMLLFPEPQELDVPCCDNCAPRYFPIECISLRLPYPTRAGRSSKPTEQLQTELEAALKQWRTRVIAQDYPDQRNVTSRQILSDATLAKIVARPAVVERFGSDVFRHIIPWQWATRYGNQVIAIVKWHLALYPDPEQRRREEAAERQHASIAEKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSP7</accession>
    <name>A0A8H5FSP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_014871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSP7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034689945" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5347669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="60886" checksum="A58C02F93730962D" modified="2022-01-19" version="1">MHRLLATLSTALAVGATLITNDTTRIPSSFEYIIIGGGTAGLAVANRLSVNHSVLVIERGTDQRDNENINNPLIATAGFPPDICHQLGSMLPQVGSNGTKLRVQPVQFGNCLGGGSSINSMQGSRPTFAGMNALEALGNPGWGWDDFLPFMQRSETFTPPNAQQIERGASFNASIHGFSGPVGVSFPDPFLVPQVHSAAKETAESVYGVTPTQDMGDGFSGGHVASMYYHIHFNETLQTQRRSSSAWSFLYPESQQRRNLIVLMEHTVNTIMTTQATTDGNITATGVTLLPSGGGEMLTFSAIREVIVSAGSVFSPGVLQRSGIGNSSLLQSLGISPVLDIPGVGSNLTRERLVPVADAFKSDPNVTMNAPTLGLISTHATASEAFRDQGTQMISSAVRNSTSASDQVIASGGIVNAQSMEIQANVIANAYEIDHPLMELLFTVGVTLRLWAQSTLPLSRGSVHINTTDPFAFPVVDAQYLTIDSDVEIFTRAARRLGLAASTPPFSNLINGTAATAFGLPAVNASDDAWRTWALDHYSPAVHFIGSNSMMPQEVGGVVSPELLVYGNKFIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT85</accession>
    <name>A0A8H5FT85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT85"/>
    <dbReference type="OrthoDB" id="2575973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034416360" evidence="2">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="20429" checksum="5E6F34C59A99AB45" modified="2022-01-19" version="1">MIFSRAISFVSLLTVFLSFTFVAANPVTFAGARSDVSTVGKRQDTDITSILTDLQSQVGQILPQIDTLVANGNANDATVTPLINQLTSAIGTSNDNLNKLPEDKKHKGDKDEIAKIIAFIVTDITKTLNGLLLSGAFIPGLGALLVTVDVVLNKLLTGVELLLAGVLKLVAVLLVDVAALLKSISFGLVLAALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX81</accession>
    <name>A0A8H5FX81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX81"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5352077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="102" mass="11914" checksum="BFD06722CEB9DE8B" modified="2022-01-19" version="1">MRPSVTRYSDMPGPQHAWNRWWGDTALQKQRGVVQYTISPYQSKAAPKMIRSYIFNFYRRVSGEAVYFVVPFALGYGVYTWAKNRYEYMNSKAGHLASGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZE0</accession>
    <name>A0A8H5FZE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZE0"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="473"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5355315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71873" checksum="87002BAACCABCECF" modified="2022-01-19" version="1">MSTTSDARRQQIEAKRAKLAELRRGPSTPRRSGPAEVDDFVNSILRDSRGPSAGFDSGDLTPSSSLPGTPLLGHATLPHSLSIGNGSGRASRQSDIGSGISGTTFAGTSNAATDSVIYREMEPRFLPDLIDIEQELFELPKKERVTYNKEVQTMATETETSTPEEDDTHRRTLTEAELETLQAARDKELEEESVQLDKEIEEEIRDIPPEELAGILSAPELLEFVDSTTKMFYRALNGYDYTRDYRVGAETGSDESEGRVKRVCEFFDERYGKNRSITDVDWSSQYPELTVASYNKNPAALNEPDGIVAVWNLHLLEKPEFVFHSQSDVLSVTFSPFHSNLVFGGTYSGQILLWDNRSKHLPVLKTPLSASGHTHPVYAMQMVGTQNAHNLITTSTDGTVCSWLVDMLAQPQETLELIHAGHNKTGEVAITTLDFPDNEATTFWVGTEEGNVYQANRYDRAGAKAGLNQYDVYKGHSGPIMGTHFHPTSGSVDFSDLFLTSSVDWTVKLWRAKSLAKPSTTPHAISPLYSFDEADDPVYDVKWHPAHPALFGTVDGSGKFDLWNLNQDTEVPIVSTSVGSGRALNKLQWDKKDGRRAALGGSDGKLYVYDIGDMAIPRESEWTDLQKTISGIVGGGQTNGIVDGEAMKIIPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G304</accession>
    <name>A0A8H5G304_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G304"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="689" mass="78229" checksum="0D3012ACD7B63365" modified="2022-01-19" version="1">MRLLSIPPHKSSAFPKLVSFRPNEIPPYAILSHTWEHDEIEFPHIQNLKTGEPDASTRKDLAELQRRAPASYSKIMGACRLARKDGFDYIWIDSCCINKDSSAELSEALNSMYQHYKRAIVCYVYLSDVRDVAAQNPRLAESDFRQCKWFTRGWTLQELLASSELSFYAKDWTMIGTKRGLHDAITATTGIPTAVLLKGDTRSISIAQKMSWAARRETTRVEDQAYCLMGIFGVNMSPIYGEGLENAFLRLQLEIIKFSNDRSIFAWTALSGDKSGWEGRGLLASSPYEFRFSGSVGPSEWNITDEDSSYSMTNSGLRIYLPLSASPDGKCFRAFLNCRDESNQCHVAVCLQHTRGKEYSRCRANKLILEPEMPTFSLLWFHTPGTSWAYCGNTSNKYDTRKNRTPEKSVRLPISFGKPGIVYFRNKQGSEFRVRAELDSDGLAAANIIIGSIADDNKQPGPSPILSRNSKNSENEIERVVESLPDNEMVILHLRKQPNKDQHRKLDIFIVPANPLIRDLSPTDLGVMVEVENSVTRLFDLKSIFPSAVSSQHFREERYYGVYCTIDPRRPFRVLLFKPQSSLSGFTAFAVILYVRNCKVTGWVHVVKNIEEKSNERDTVEAVLGMITENKNFKKHEEHEENVLQRLPRPGTITQSTYLVKAGIRRRQGKALQPEPGTHTAWIKLGNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAK6</accession>
    <name>A0A8H5GAK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAK6"/>
    <dbReference type="OrthoDB" id="3052647at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="31271" checksum="3E82F9851651D6C1" modified="2022-01-19" version="1">MSFHTVIIDDQDARISYSGQWSVGGSDANYRHTLFSSQNTSASAKFTFKGTSMILMGDIDSGASCNATISLDGSTYAFSSPVTNTNLHQTVLWSSPTLPDDSHTFTYTVESCTDSSAKLWFDYFLYNSTSNNPSGGETYFVDDDSANLQYTGDWERSGGDGDFMQTMQGGKVGSSVQLDFEGSSVSVFGRVDSFSSGIVSALFSVDGSTPVSFATSSQSFISYNKQFFQSRTLSPGQHTLVVTPNSENPIWIDYLLIQNGTSSISLQATTDSDSDSSSHSDSTSTGKALAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAV7</accession>
    <name>A0A8H5GAV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAV7"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="101308" checksum="3E696201A54741DA" modified="2022-01-19" version="1">MHTFDCKGWLSIKIFEGDPCAWIHLKHKEDHILYDGSVLPEELWTEILKRHPKPLFKCRQVASIASEARRKQWCRDPDELKSAKIILDEFNLPSVEGYSGIAFSLPDVLLKFGGTIREIALDSAWNTNGSKYELYALLGESGEAGVKEDYICSFLEHFKARYDLNPSFTLSDKDLSEINAFLKAFPEAKHQLCFWHCLRAVKQQLSILQRPPKFYNVTEARNEFGDAINKNFVPVGQVTEADRVNFAVAENTIPRLVPVQYDSPTPDSSDGVSPKLDDISWEEEDAYTHDPEFSEFFNNDDADNEFGPDWMFDADEKPSKDPNQPISPIDIDYGSENERELNKKIDEKNTERRERKLLQAIGDLHLEEGEELLDTASLWSIPDEEYVKIKDNLEIFDRVKNDLLGRWHSWIVETRAAEKALKDKKENNVAGSDLMVAKEMEEVSREIETFLDIKFSNELFIVANFDYIPLGIFKMKHLHVLQSTAASFSPKTVYYQDQKAKDTKKYKIWDIAAISKPLGINSNDFEGCDSFLDFLEATENYIRFVVEWDPEKTGSKHATFIYHHAAFFKNPENADFYNCWKSTEKLLCEERRTQSFKFDIATYREKMQSCRSDWKLAQGLSNITGSSYSGRNGSAYCSGGMDHSHGNSGGSSADGRYHPFPKGDKKTFASCCLGCAEEEHKMQNHPQDKPTLWGKLVGKDLQNPKTGHSLCIHWNLFGTQGGRGRNQDSFCHTPAYLPTVALPHAYFAYPAFHIASAPKGTQACALDIKKFHRTVPALPHHKPYLIVQDLHGKFFVDHCIPFGCASASSNAGMIANATIAIWAAKGMMLVKRCEDDFKPLRTPTGVKPNISGTDHFTYDYDKARMLSLIEHLGIPWHSAEDKGDAERLTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB84</accession>
    <name>A0A8H5GB84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB84"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="578" mass="64738" checksum="A893792904A74BCB" modified="2022-01-19" version="1">MLCQKCSIRIEPDSDATPAHFIADLDERLRSMTASSSSENKRIHDLLRSSEDEFKACQLRIALLAKRCNTLKAHMRRAQSLLAPIRRLPNELLVEVFQWLLTSKESALDGQVFRVEPLNFMRVCKRWWSLALTTTRLWAFVTLALLVPSSCTNNVIADRANAFKHYLSRSNSFPLKVSLLAHGQDHSGDPQVKELYLHSRRWRSLKVSLLDNTAIPTVDQLPSLETLEIIQCRGSHLPIISSFLQSSPKLRNLSLLNIPDQVVSAVPWGQIADLEVFQRTCLAVFSGEGRCNSLVNLRIHNADDYPNPFRHGIKPQNISTLRHFTISFKGFSNSTRQALQPRHDPNYGVLRDLLSFLTLPTLHTLEFVFESTLHDRGMTTPPLALISKLSDLLRRSGCPLATLIFDNVTFTAEQVLLLLRQTPSLADLVIREPMAPTPKPTIATSDVADCSTRPCPSPMPIITTDFLRALCVPETPDPFASSISSSDSIIVPKLQRLTLKVQGSSFDDASFVDMVRSRWLPGTVRDYGLAGLEQLAVVDIQVVGRRVDKQIWKRLDCVKASGVNLRLLDEDSIVAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDA7</accession>
    <name>A0A8H5GDA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDA7"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5362836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="46670" checksum="BD59CC5346E72A47" modified="2022-01-19" version="1">MTINLETPYTISIPDSKLSILQQKLAFVTFPDELEDSGWDYGVPLSVAQRLISRWKDGYDWRKIEKQLNEELPQFTRDIEVEGHGVLKIHYVHKKSSKNAIPLLFVHGYILFQFSRPGSFLEVRKILPLLTEPESAQDPSFHVVALSLPGFGFSEAPRKKGFSLRQFAEVCNKLMLSLGYDRYVTQSGDWGFYICRTIAQFYGGKHLIAWHTNYPDAGGDVPTSPDDPSTASQMDLDGYARNRWFFKDSFGYNTEQTSRPQTIGYSLADSPLGLLAWIYEKLVEWSDVDAYSWSDDEALTWISVYWFSEAGPAAAGRIYREVQYKEPNDREAANVCPQNPRPDIPMGWSRFPRDILYYPLASVQKIGNLAYQNYDHKKGGHFPATEVPEALVKDLRQFFRSVVDVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDC8</accession>
    <name>A0A8H5GDC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDC8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="403" mass="44760" checksum="88B615B6B6BBFE19" modified="2022-01-19" version="1">MSNSRRPQDRKTSHQYSTQSARDPPPAYSTSGNINNNQDHSNIRVVHNTIHGSQHVSASHNSSATTGFHNTQHLTTVFSHNIDSNQWDSNNRVEGNVGSFNGTGIQQFMSSSGPNATPFPDRVPRNFTSGSWYSDNHNSNHASSGNIISNNRDSFNATVQERLAANSANTYQSLRNQPNATESHRYNMNQHQSTTSHNSQLLSAQRQSGSTIWSNNVNSNHSDLNNRIEGNARAFNGVSMDQSPISAITGARARNNPFTQNVPLDPNTAGDITAYSHNENSNHFNSRNSISNNTDSFNSAGAVNPWQGLNLQVEQVVAACRSLGYKDEELQDLRLEYWHHEVLKLCLGDNHDGRGADQSAHDLLHQLMQKIRRHRAKGHTIPNKTRRLTSSSIPFDAAYRDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDH5</accession>
    <name>A0A8H5GDH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDH5"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="939"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="531"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="937"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="779"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5362953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123270" checksum="E572046B9AF87D72" modified="2022-01-19" version="1">MSSAPSPTSDDSDNHGLSSTPTPYSHMHRSFSHASHQQWTPQHHHQGTSYFPSSSPSISQRPHPILMRSSSAHSARRGMRSASVSSATRGGDVLSEADEYDGDEERERERDRLGKAAVAQVDSGEIDDSPDDADNDSDRDDEDPITLKERQSLINVEHPFGLPIWKPALYKKSRSVTRYADQALHSVPSAQAERHLLPGNLFWLVVFGWWLSLVCFFVSGFLYIIPNGGRRYSSLVFGLGWYIAWPFGKYVEGAADDMDVEEDEEDDDEEDDGVDAEHSGSDAPTVRLNRANDEAHATVRGPPAGSQHVQNPSWNSGSTERTSLLHPEVHGLAPARSYGATPSNSSAPDLSKDDTKADILGKACFWITFVCIIAPLMLIVCLICWGLVVTIPMARLNWALIKHIFEQPDNIRFCSAPVEVIVSTPDGPASDSTDDTAVQPTYSVKTTRLTPGQVAPSGSPSSTVLLCTYRAVGWKYYKYTVGGVNIMFVNLMGVVFFCIFDWAVLLTWLEELEEEGRPVPAFLSIIASQGLIFTCGLLSVIPLSYFIGMAVASISAQSSIGMGAVINATFGSVIEILLYCLMLTQGKGKLVEGSLVGSILAGVLLMPGMSMVSSAFKRKEQKFNAKSAGVTSLMLIMAIIGALAPTMFYQTYGNFQLICTGCPTGPTTGNKPWICDQCYYQHLDPVADPFYQSTVKSLMYFCAVILVFSYLIGLWFSLRTHASQIWQNPQQLLQPGAELPLHHRQSLYQRLIPHSAQGHSHGQSGGYRTLRHRASNMTNATNDGVASRPQTPMTREGTGSGSGTNPNPSGPPSPVLPRRVSYAPPPALGSGAPNIGILPSTPGSSHGPIPPPPGFSPILESVGHAVKSAGLQPISLPESMSQDDFTRAVAVATVSALRHQQHVGVSPGRLQRAVSAVDPDGHSGGHDAPSWSRMTSASVLLGCTALYAVIAEILVDVVDVILSGSGLDEKFLGVTLFALVPNTTEFMNAISFALNGNIALSMEIGSAYALQVCLLQIPAMVAFSAWYAPEQMGRVAYTFSLIFPRWDVVVIILSMFLLTYTYIEAKSNYHRGSILILSYLVLASGFYFAPQNEEFEPEHGSYLSPSSSSSSSFTEFPHLTALQFARWYLFSWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDJ0</accession>
    <name>A0A8H5GDJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDJ0"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5363064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33475" checksum="3A32BCB56F9A1A4B" modified="2022-01-19" version="1">MPTDLIWLITGVSSGLGLNLAKIILARGDKVIGTTRTLGGKPHHAPQVLGGDSNEENYKLIQLDLDWDTEKIQKAVTDAVGIWGRIDVLVNNAGYSHKGLAEEVGSAGFKQQFQTNFFALMDVTNALLPHMRKRRSGTIVNIGSRTSWRADFPGASIYGSSKAAVRVYSEGLATEIAPFGIRMLIVEPASFKSDTFSKTPWDDKNLISDYAEVGLGPKQINEAIQIRVKQMKNDPHKGMNVLADVVRGEGVALKEEGNAKELKKWPLYLFLGKEAVEGFKEKMEIMVEKTKEWEGIVGDLDCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDK6</accession>
    <name>A0A8H5GDK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDK6"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5363079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="518" mass="58073" checksum="EE40F3802F77EC96" modified="2022-01-19" version="1">MVAKNPLLGGRMSIRKRFMATVINDIWPEVVFFTLVATMVYLVTTKTDVHLVFSNALLSVLGTVLGLVISFRTSSAYERYQEGRKMWTNVAIQCRNTAQLIWLHVPNERPAKDAIAAMSTLEGIIEKKSMINVVQAFAVSVKHYLRGESGVYYQDLYPLISFLPRYTSHGGQTEADMLPLWQASEDGDHPYDHTQSAPASRMGSLSEAEMGMGTATATTLSYDGSRPSHSRKGSSFFGSRRNHDYVDAEKVLPTVQVHRPLKPARNPPLSDIFDYIPFLRIFKVLARPFTGKKEPQVAKRSLMGRKRQPELGDSNVPLEIIMFLSGYSAHLLRAGAIQPAPASALVTAINNLSDNLANLERIGNTPLPFAYQAHLRMSLWIYLFFLPWQIETVMGYLTIPGTAFAAFLFLGFLEIGQEIENPFNYDLNDLDLDVFCLSIQRELNEITAHHVPADPTSYIFSSWNQPFAPADRRSAEDILRQGSQYTNTSAGADSQPGLMSVQRTLLKAYRDIDEHTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE08</accession>
    <name>A0A8H5GE08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE08"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="251" mass="28585" checksum="CF584849EF260522" modified="2022-01-19" version="1">MLAPLLSTLVLHGKNRHAKQQSACFPSIQGFLRSSQCQLQRLQLKEDFLNTSRLLKLLEQTPTLEHLNIDGGHGQHGIFQALTVKEGSELDASPKGRSKRVLVPRLTQLDTTIILCPRNQRQLEKELAAQRVEGPSDGGDGSKADEIYSMVQSRRQKHGQIGDEDVACMRFFRLSVQHYGPNVDTGRWINRFRSSTVPRLRNLTKDGLQLPELEINTMIKRQQVRWHFDWKDESSSDEDSEGQSNDEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGP7</accession>
    <name>A0A8H5GGP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGP7"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="48"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="22684" checksum="537613667DC00E56" modified="2022-01-19" version="1">MCFTKRQKDLFSDQIKGKDDSKNPPSSSQPPATTSTTTPATTAMAPKIAIIIYSMYGHIAKMAESVKKGIEEAGGSATIYQIPETLPQEVLTAMHAPPKPNYPIISAEQLPQFDAFLFGIPTRYGNFPGQWKAFWDTTGQLWFSGALAGKYASVFVSTASPGGGQETTVVNSLSTLTHHGIIYVPLGYSTTFSQLTNLDEVHGGMCLPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGU1</accession>
    <name>A0A8H5GGU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGU1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="458"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="558"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="562"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5364741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="82271" checksum="31592B24636E71DE" modified="2022-01-19" version="1">MSSLPVRRTTRTTRSISNSTTKDNNKDKGSENANARPRPKPSRSMTTRTTNGKALPNTITAGAGISEVPANVHRSAATGLSSTAASRAKTAAAAGENQTAGGKRKRTTVAAAGAVGGAGVGLGKGKEKEKEVEETVGVGLKSTKATTTTTRKPFGLVGGTATKTTTTTTRSMSSVTQKTTRATAKSTSITSSRKNQVYVDADVDEDTRGRSRTRPTSTSASASASAEASSHTNLKNIVGTSRTSSRHHHLQHITEDDNDNDNDTEDFRASKRRHTEEPESDAGATAAQDVDVDVDLDADVDVDLDLDLEEDTITVPLTSTSIPTSAPRPAVALAPSAGSSADDEERIAAELNVVEQDDDGGDGDYYMQTPGRGMKQEEFERDQGRQGLVLKKEEEQEQEVQDWDDLDADDFDDPLQVSEYINEITAYMKELETKHLPTPNYIALHTELDWEKRQILVDWILQLVNRYAFLPETFFLSVNLIDRFLSLRQSISLERIQLMGISCFSIASKFEEGVSPSLSELAHLTGGTFSAENISRAERYVLKTIKYEVSGHGGGGGGGPMSWLRRGSKADDLDVGARTIGKYLLEAACFEGELVGTKPSLVAAASLWLGRIVLGREEWTPNLIHYTTYKEHELLPTANVLLNHVLKDISPQYNETVYKKHASRKYMKSSIFIRKWALSRFPRNANVDLWEMLSVIKDEIREERAERELQEHLARVEKEERRKARALAEAEAEAEARETRRVPEEGEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH63</accession>
    <name>A0A8H5GH63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH63"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="67"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5364758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="599" mass="64240" checksum="06892F0308CA165A" modified="2022-01-19" version="1">MSDSTLATAAPSADVQAVPVIPALVEVTALQANVLPSQLGNERSKIKKEIQLTDQTNLLPAKQVIVIFFCLSFVTLAQSLDSTIVATSLPTVSGVFNGGSVASWIPSAYLLTSTAFQPLYGRFSDIFGRKSTLCSAVFLFVLGNLISGFSKSIIQLIIFRGIAGAGGGGVISIMQIIISDIVSLRERGKYVGVVGVVIAVGSCVGPIVGGALAQHVSWRWCFWITLPLAVVSTAITVLFLPLKPVNGNIGRQLLIIDYLGAILTLAACTLIILPLIWGGVTFPWGSAVVIAPLISGFFVLATFCLWEWRGAKLPIVPMYIFKHVTVCGVYIVMFVNGFVFYAALYYIPQFFQVALDYSPTRAGVWLIPVLMGQLSSSMLAGLFVSHTGRYRTIVYCGFALCAIACGCISIFHETTSRPVMVVLMLLAGIGNGATMQTTTVAAQASVPRKDMAVVTAFRNFIRMLGGAFALPVASALVNNSLRSSMHTLALPESTISVVIDDPTILSNSNIISSLGISPSEASSILNHGYTIGFRDLFFLNAALSSLATVVAVVMIKHKELIRPDEEELRRKAKEEVMKRNQSDNQWDGGEKRAPENGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHK6</accession>
    <name>A0A8H5GHK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHK6"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="233" mass="25412" checksum="99B1E5E6130302CE" modified="2022-01-19" version="1">MAASNTLYILNISCQRSSQSILCALMSLASQPSGPLVDADIFAIQEWVAERAISSLLYGIYAALSLTTIFLLLAKGLNSKARIGLTSLTTLMFLTSTLSVIFSLEFILLQIPLGGFNPPDPDAIIQLTTNIQIASEFMEKVNFVLSDGIVVWRAWIIFPRNLLVKFVLTLCMLGSCAGTFTVEGSLVAEFVRNPDSSNAGRRGTISIMAGPLLFTNMVATLLIGYKTWWGFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHX6</accession>
    <name>A0A8H5GHX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHX6"/>
    <dbReference type="OrthoDB" id="3256015at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="758" mass="82648" checksum="14A5CD753D3FAB04" modified="2022-01-19" version="1">MSVVKPPTRRARRDGLSISDAEPESISKPSESALPPLQAGNGMNLRGKRDSHPAAPDMSAPKRSTEEVQAEKRAKEQARLAKAAARQSAVNKAAEVEDRLRMSEQQAKETGHNPPTTTKTKKPRQKKKDPKDTEQAAEESEQLAGDRDSKAKNTSTTAQTPQTKRKRTAPATSTARTSASLSSPTTTSTTPNKSPSQCDIEDLEDDEQAAEGLDDSGYEAKPVKKKKKGELRAEVGQKRVSTASEASVTVTEPPKKKKKLILQGFKSSTNTVSNDTLNNITTSSIFGGDISNQAATTITQPDGAEYVSGGFGDEIEGHDERETTVKSGSKPLKMKTVSAVVPQSTIVKIEPTTSVQGLVTPARKRKQVRLADLPGPVKTAFSKTFMPVIIEYTGCITAWTGPNVDDLAELWASVMSETLLHQFAELNKDQTIKTLVDQQLSSWRNTFAKTALAALEEVFKRQHLESPDERKAYIAHQLEGNYKCRSFYYLNVMKKDGKTYYGGPFQSYLIAKTLSEHLKSIKTIAKEDRLDMRPVGAIVLSIQAVQRALTFNESGVRIIPHGQDRYFSQQVWGDRFVNLDGKKVHQKTTSQLHWIFGENPSTNTARVSSAQWDQIIEAAQACTTVKNVSKPATTSPTEEPIDSDEDWTMPDEDPDFFREHTNRDGKGGGPQETETKDIGEETTKTVTAASAVDKDESAGNDVSETTKTAAAASAVGEDEDADDVSESEVVDDGVNDADSTSSEDDEEMEEEVGTASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIM7</accession>
    <name>A0A8H5GIM7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIM7"/>
    <dbReference type="OrthoDB" id="3188789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35637" checksum="7298B3705C91D6F7" modified="2022-01-19" version="1">MPSPFLILRFLFLALIFYLSLLTLIFSSWNINVSSSAGLGVPGSSAFLILNSCLVFIVISLGLVPLVWPQFNTAQVIVECSWSAILGLLQIGAAIATTVVSSSVVHQTDDSAVNASSFLLIPSTWLSSLCTLAYFLILLLTSMTHLRHDTDLWSKSVYDVKWFGVSTAGLDSSDVSAPRPKTGFEEDTWAKYLDDIESTAGRKARFPAADIEKAPWASNDVRRGRDAPFQVSSRNGSESSSRQSSVTPSPRSNDALPPLPLRVEPKGLPIASRFIERFRESQQLTRAGTFNAFAKEVEDHDLPIPLTRFSRWIRADGAKNNGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIM9</accession>
    <name>A0A8H5GIM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcriptional coregulator SSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_003212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1312"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1315"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5365642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1347" mass="149177" checksum="323646112CCBBD7B" modified="2022-01-19" version="1">MFRKSSSDSSSKKESKNNSSNSSAPPPPPPNTAKPLPNPAVSLNNTNSNQARSSSPASSAPSTPDRRHSGDGVPLTPPIVVVSPDSSASITRGQHPAPGSERGSEATPPRNTTLNRLRAGPKDTIPMVGKPPRKQRSSRFVVTEKVEIERLPPFMETPPADRSQLFVKKLHQCRVLFDFNDASADLKGKQIKAQTLHEMLEYITTQRGVITESIYPEVVNMFGSNLFRSIPPPVNPTGDAFDPEEDEPVLELAWPHLQIVYEFFLRFVESPDFNTNLAKRYIDQPFVLSLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSINNVFFQFIYETEKHNGIAELLEILGSIINGFALPLKEEHKIFLTKVLIPLHKVKSLSLYHPQLAYCVVQFLEKDPSLAEDVMLGLLKFWPKVNSPKEVMFLNEVEEVLDVTDPVEFQKIQVPLFQQLARCINSQHFQVAERALLYWNNEYVVNLMSDNLAIVLPIVFPALTIHGMVYNALKLFMEINPDLFDESMQQYKQRKLEEHEHAVHRYEAWQVMRNKALSNAPNGKMPEGYVEIPHAPPPPPPVVEDIDVLDLSMELNAASIDDVAGDLDEHGVERVPMADPGLDSSYNMATTELSPTSGHQSPHVRRKSVLPVLMTLEETAFPDQVHEVLDRGTGNIHLSSIENPPSLRSLILRQCAIDVIIEHTIMSSSKAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVSFSDTERLIGDAAKNQVAMNPLNTVFDAKRLIGRKFDDAEVQADIKHFPFKVLNKAGKPYIEVEYRGEKKEFSPEEISSMVLLKMKETAESYLGTTITNAVVTVPAYFNDSQRQATKDAGTISGMNVLRIINEPTAAAIAYGLDKKVQGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKNKKDLSTNPRALRRLRTACERAKRTLSSAAQTSIEIDSLFEGIDFYTSLTRARFEELCQDLFRSTLEPVEKVLRDSKIDKANVHEIVLVGGSTRIPRIVKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILSGDTSEKTQDLLLLDVAPLSLGIETAGGVMTALIKRNTTVPTKKSEVFSTYADNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSASDKTTGKSNRITITNDKGRLSKEEIERMVSEAEKYKAEDEEAAARITAKNGLESYAYNLRNSLTDEKLADKFDPADKSKLEGAVNEAISWLDSSQEASKEEYEGRQKELEAIANPIMQKLYASAGGAPGGFPGAGGAAPGGFPGGAPSEDGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJP1</accession>
    <name>A0A8H5GJP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJP1"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF1">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034982281" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="767" mass="82204" checksum="193BBD68C527E5CF" modified="2022-01-19" version="1">MLGHLALSLLLFIGSAFAQAGSTYVDPDNGITFTGFTDPVHGMTHGYVFPPANSGSTEFIGEIVAPLEAQWAGVSPGGTMINNLLLLAWVNNGKVVGTNRMANDYIQPFTYAGPIITNLPSTKVNSTHWKWVYRCQNCTVWNTGSLDTSSFGPHGWVYSTIPVDNPSDVNTNFQEHTDFGLYGADWPDAHVDQATYDTWASGGTASPPPPTSTTTTTTTTTTTSPTATAKPTPYDYIVVGAGPGGIIAADRLSEAGKKVLLLDRGGPSTWQTGGRYQPAWLQGTQLTKFDVPGLFETMFTDPNSFWWCKDINVFAACMVGGGTSINGALYWLPAQMDFSTSAGWPSSWGNIQPWNDKMSARLPSTDHPSTDGKRYLEQVYNVVSQLLKPQGYSEITINDNPNFKDHALGYSAYDFVKGKRGGPVATYLQTAQGRGNFHMEMYTMVTSVTRNGSTITGVQTNNTAIGPNGFIPLNPNGRVVLAGGSFGTPRILFQSGIGPTDMINLVKADSVQGPQLPPQSAWINLPVGENVSDNPSVNLVFTHPSVDDYENWGQVWTNPRPADAQQYISSQSGVLAQASPRANFWRAYSSSDGHVRYLQGTARPGAAAFPQTGGFNQSAMFTITAYLSTGITSRGRIGIDAALNPRVLTNPWLTDPVDKQVLLQGLSDIVSSIGQVPGLTMIMPNSSQSMSSYLNSYSLADMNSNHWVGPCTIGKVVDENTKVMGTNNLFVLDASIMPSLPVGNPHGAIMAAAEQGVSRILALKGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJU1</accession>
    <name>A0A8H5GJU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJU1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28237" checksum="D61B65FF30DC406C" modified="2022-01-19" version="1">MSIAHGIRTVGVLGAGQMGTGIALVSALRAKVPVLLYDQSQDQVKKGLAFAEKLLEKDISKGRIKSEEAKEARDRITPVDPSLGLKGFRDAGMVIEAVSENLALKQKIFSTLAAELSPDAILASNTSSISITKIAASVIPQGASAASEEGKKSAGRVVGLHFFNPVPVMKLVELISALQTTPEVLDRARSFAVACGKEVTTSNDVPGFVSNALLMPFINEAIMCLEKGTATRDDIDTTLKLGMNHPMGPLQLGLSSFLLLTSSLDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJZ6</accession>
    <name>A0A8H5GJZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJZ6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5366393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59271" checksum="7FD7E0847AA8B55F" modified="2022-01-19" version="1">MSLQLTRSDILLTVILLSLSYVLRRRSKASGFPKPPGPPGYPLIGNLLDIPNAKQMSDEIWAKWGQKWGEIVSVSVLGTTVVVINSFKQSIEMLEKRGAAFSNRPFLPMPMEVLEMRDSMGLLRYGRALTSRRALFHQELGTESAVRAFHSELERLGKKFLQRLLISPEKALDNCHHYSGSIILSIAYGYEVQDSSSNQYDPMVKIVTTAMDNFNHATVPGAFLVNDIPFLLKLPEWLPGMGWKKLGRIWAKEYWDMIDVPYAFVKRKMMEGTARDSFTSKWLSKNLSELKEFDLKLTASAMFGAGVETTAATIYAFLILMAMHPEIQKKAQVEIQDVVGLGRMPTFEDMKDMTYLHAIFKEVIRYHPAVPNCLPHSNPHDKVHNDMFIPKGAIIFVNLWNMARNPEVYSNPMDFNPSRFLGESPEQDPREVIFGFGRRYVNAASSHFSDLQFLSMMSVRICPGRRLVESVLCITFAMVLASFNISSDAEAPVKFRRNPGIISHLDEMKLRIVPRFDPSHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLN3</accession>
    <name>A0A8H5GLN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1419" mass="153770" checksum="84EC60D4A43F4B54" modified="2022-01-19" version="1">MQTLEIDTRRRQDAYDLRGQIHSDSDNEYGHLDGHGDAGNYVGTDDEEHSVMEEDSDQGEGEDDFIDDMDDGSSSLSIPNESIDFDLVYSLHSFAATVEGQANVVKGDSLFLMDDSNSYWWLVRVLKTQEVGYIPAENIETPFERLARLNKHRNVDLASPNQAELQENLAASQDRLIQNLSRQGRTPSPNTLRNNRKSVDFRISKRFHRYPPAIWREEEEDEEEDVEWDEGEYESDDTDLAAEAEERSRADAASRAGSTVMDVDDRDEESTGKVRWGDQGPAQPTQNGGAGGNIPITLRPGEQSQTAEQQQIQIQRSLDSISPQRTSPQNTLNPADNQLSGANAKGRISPANQSPISPGSSGPRRIDPLDQQETVRVTMTPSIARDSEESATYNSNAIARQEEERKRRLEVESEENRKRAKGKDAQKMAPPVSSASLNVSGNGGRKLQKERVESSPDDDGKDKKKKGGSLLGGLFSRRKDKDKKEGKSSISSFETDIRASEDSSRSGGRVSSSSGHDAGMAASPTTEAAMQQQQQSQQLALRNSQDPRRVGGSSPGSAASPTNIPTQSSSASVSESVSSSPPSISHLRKQDQEQQALYLQYLNRSPSAAPEPNYGTLPARFNNASVGGGGLGPPVHKPRPGSIILTPTPWMEVMFPSSATSSAELVKQAIQRFRLPVEGEDGGVSEYYLTIKQVEGSSAVLKGHEKPLEVFESLQAAMDEESSNFLLPKVKRSSVGSISSVSSNLSMHPAIKKLPMNDFTDDSAVKFYLNRRSADGRDSALDDMIEEEGDTLIAADTSIGSGESVGGRPQYLTVTTAGVHNVQPERFHSPSFRFAVQVSEAIVFKGTLKDRDSRSLSISSNLSGLSNTMRRKVFVFPKNATVAEVIEIGLERFGILEGVVDGGDEVEDKLSKRRSAQRVRYVLMVEGGAGLSHERELAPSSKILEAYSRPPAFRPAINHSTNMKRRSVDSGQLLGSIEDVSPDDPVFILRRATSYRNTSHRGKRNSAPLDELALRNLHRESASSSISSSDQTVQAAHAGSSVLGAQQTEQRSMKEIIAAQREASRANQRKALATQANAVRGVDVLYLEMYASEYDISDIVEEEFKNAGDKNDLLEGVGAGIGKKDSGLDEKLDRVLSRVKNERPPPRVETPPSASSYGSSHRKSLSTSSAYSAAEETIDGHGANYGSRSTTPVVSQQNVSTRSTPTQPERGVSPTSRSRSNTPATAATSLGSRMFTPTERVASPTSTIGRSSPALDELTGNVMRSGTVTPLSSAGRPGMARRNPSVASAASDISGYATPATHITSASSTGDSDYGGANTPLPKFSTRQMNIPGAAGAKNDFGVSHMMAVIEYRALASKPKVGIADRGDPVDEMLFGRKMDLAALHPKIRDVYASSFKEMEEMDQLLDQHLQQAHSTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM67</accession>
    <name>A0A8H5GM67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM67"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28081" checksum="4022FBEAA6FE2735" modified="2022-01-19" version="1">MHRLGGVGLSAFDRHNQSQRSFAQLSSQLTQAQISHLHSQLAQFRTALSNFAVTHREHIKRDPRFRHEFQQMCASIGVDPLAGPRRGGWWAEMVGMGDWQYELGVQIVDVCVSTRERNGGMIEMDELIRIISKLRGVSGGEITEEDVVRSIETLKPLGAGYQVVDVGGRKMVRSVVKELDQDQAVILAVARQLSGKVVEEDLISRHGWTRERARVALENMCLRDGLCWVDDQDPSGMAYWIPSAMRWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPC7</accession>
    <name>A0A8H5GPC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPC7"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="440"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="906" mass="100307" checksum="ADF4291BE7F19293" modified="2022-01-19" version="1">MFQRSRSPKPPKPSRAETEYLRAIMADVTAAPVTNSHPFGFLHHESFTHVDTDSLGSSSSAVPANSPGSQPHSSQTYSNANALANNLWMRLGQLPLPGVEECLKMFTSVEVLDGENMVGCRRCWKIANGWYEEGARAERREERRKRREQMDEESDDEPEEEDDEEEESDEDGRDGDESGVDDDDGDDEDFSTKASEESTTTEDGNERRLRQTSSAPASPSILPHPMTTSMLYAHQNVSDGFSLTGQVNGDSIPVPSKPVLTVQPSSRAVNGVSGGISDSADNSVPPSPTLLTARPGNIGFAAIKGEYIPNNIVSQSKDSLLSSTTSSTGVDGDHYRRRHDECTTPSTTDYSSDDNSDTTSISTAASVSVRSVESSAWTSVSPAKESTTSQSSSSVHNQQRISAPAMQISRSDDTSAASQASSSRSSKPKKSKLPKPTIMRPAYKRYLISTPPPILVIHLKRFQQVSSKMPMMSFSSGFKKLDDYVTFPEFLDLTPFMAPEKEDFGLGKKGREVKKGQGQGLGKEKEKKKPKETKERFMYRLYAVVVHIGNMLGGHYIAYTALPNSEDVGMDKTPPAGIDPNAPLPIQSGRQWAYISDTVVRFTTLEEVLKAKAYICMSPSIWHSSFLLQLKPAQRSIRPTPKSIMSSSVVHTNVSKVSVDGGIEVFYREAGDKNLPAPDMPGFGFTAVPKERNYKYTFDNIAKTIEAFTHALKLDSFAVYIFDYGAPTGLKLALARPTAVKAIISQNGNAFEEGLGEFWAPIQRYWAEPTQENREKIRFLTQFDATKWQYVTGEAHPERIPPETYYLDQTLLDRPGNADIQLDLFLDYQHNVTLYPAFHEYFRTRQPPLIAIWGKNDQIFVAPGAEAFKKVLPNAVVKFLDGRHFPLENHGEFIGSEILQFLEGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS60</accession>
    <name>A0A8H5GS60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS60"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22573" checksum="6D135A25B9B970E4" modified="2022-01-19" version="1">MADDPLAPRQEEETDAHFEPVIKLTEQVDTKTHEEDEEVLFKMRAKLFRFDAPSAEWKERGTGDVRLLAHKETKKVRLVMRRDKTLKVCANHAITSDMKLQPNIGSDRSWVWKVAADYSESPPTSETLAIRFANAENASEFKGQFETAQKTNAALNAGAPAAAAPTEEKKEEPKEETEEKEEEEKKEEAAEAEKKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS80</accession>
    <name>A0A8H5GS80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS80"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="38982" checksum="FBF97BCBD401E30D" modified="2022-01-19" version="1">MIYERCRALNIPHRKTGKLVVATDAQKSYIEKLHEKSLRLSWPPHAQPSNPDITVLPTELISGDEARRLEPDLSQDISAALWCPETGILDSHTFMESLEKDIMDSEGGELAYETRVVRVDPYRGEGNSVDIPEEEQGWVVQTLTGDANETDAFLVRNFFNASGLSGPFILNSLLPPEQQIPIYYARGSYASYKGPGIGGVSHLIYPCPYTGPNAHAFESLGTHLTVDLNGKVRFGPDLEWISPPSELDASSEGAIDFWTRHLVPSDSRLVEMHQAATRYLPQVQLEGMQPDYVGIRPKLIPPGGGFQDFVFRVDYSSTEKRKGPMVSLLGIESPGLTSSLAIAEYIVEDLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSF0</accession>
    <name>A0A8H5GSF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSF0"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="41"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="280"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="430" mass="46983" checksum="D6577D185E663A35" modified="2022-01-19" version="1">MSSTAYAGPWTSLPTTLTSWILDVIQSMGHERMTPVQSATIPLFMKHKDVVVEAVTGSGKTLAFVIPVLEKLIRRENKLRKNDIGALIITPTRELATQIYGIFTMFLAAQPRPLTEDPGPSTSQYPPPLLLISSSQSSPAQDIERFLSTGADIVIGTPGRIEEFLLGKGQFVVNVKELDVLVLDEADRLLDLGFQVTLTKIITHLPKQRRTGLFSATMTDALSELVRVGLRNPSRITVQVQVKGEGGSNGSSDKKGRVIEEQRIPASLQNYCVSCLASEKTVQLSRIISHEVQKQQSSQFIVYFATCACVDHFYHVLPGLLPSGTKLHSLHGHLSPSARTRTLTAFSEAISTPASPSVLLCTDVAARGLDLPHVDVVIQYDPPTDPKAFSHRCGRTARAGRSGRAYVLLVGREVEYVGKSILLSFSISEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTD7</accession>
    <name>A0A8H5GTD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTD7"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="170"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="252"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="355"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5370706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="61547" checksum="A06E534A7EAB1D7D" modified="2022-01-19" version="1">MATFAQEPVSYTPASVVNRKASQSTVDEEKAARSDVHSTVSPDDQPHPEQPPSWHHRARIILLAALSALILGWWISATVLPATRHRWIVQTLWAWFFLLVIAFRFIPNSVVTKPVGAIWQASVQGPFFRLPYNIRLAIGWLCLLGIVFGSAFGFKLENGTTYGDRAISVAGLLIFQCGFYLSSKHRSQIPWPTIIVGLFIQQVVALFVLKSGAGFSIFNWIATLASDFLAQADAGSGFFFDADTIAKHWFFVNTLGAIIFFIAFVQMMYYLGVMQWLLGKFAWLFFKLLNVSGAEAVVAASSPWIGQGESACLVRPYVDLMTESELHLTMTSGFSCIAGSVMAAYINLGVPAENLVTSSVMSIPASIAISKMRIPELDEPVTRGHVVVDRGSEEKNPPANALHAFSKGAVFGLIVAGQILTNVLTVLALVAVINGLLTWIGRGFGITELTLQLILGYVFYPITFFLGVPRDEILRVSRLLATKLVANEFAAYKDLQAIMNGSDPLSRRAFTITSYALCGFANLGSLGIQIGVLSAMAPSRGKIIARIAFSAMICGFLSTLQTAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXG3</accession>
    <name>A0A8H5GXG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXG3"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="585" mass="64939" checksum="F74E52A931FFA1AE" modified="2022-01-19" version="1">MTTLSNILKTSSSEDLSIDIVALITSAANDDTPKYTLSEIRDALKDANVVQHLDPLNALPSLLPCPDPAAQEIIGLMRADANAKEIVIAVEESLERLHRTALEDGDDEDDEATDNRPNSTLPLSEQILRLLGLLKGGHPQVLAKQFDTDSGRASILASAELVNEVVDWAEKKEGISTEETKAYRNVLTEFIFTALPSLSSTVKSSLSARAFSLCFPRLAFREVIDPTWKTGDQAMQAMVSAYLKVEGTATFSPSLLSPPNQALLILYAHWLMKTADESFSSSTTTKLTYLEVVFPVILQSIQTNHFLEETLSILLLSLHHLQLSKNSAIELSPDLIHPLCTLLPHLAGAHPEPQVRHRTFRVLGMVLKSSPALVRMQVLRELTGPSEQNQESSNDDLEAIEEARRQLMRIAAIGLVKEAIMEALQESASSDQSAKNPFVTPRFLQTFGPILFRTQPEDYFETLSRRIESLPEKEREQEYLVSLNKELEGEAELTRLVECLSLLYVLLLRDGRNLTGLRDKDNVANIERTLLAPIRRLLETVFDVSKDGESEDRHAQLHSVMPLVALKLGIERLDDASRDLGLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXL5</accession>
    <name>A0A8H5GXL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1430" mass="162612" checksum="EB6C18079FEA7783" modified="2022-01-19" version="1">MFSIWSSGSTPTPTPIPSPPPVYEKAEKPKTRGNDTYSVNIAPIDLAYKITSKNFQIHAQKKLEQSRTGPASKTYDFVNSWYNDNFSALHVAATTMQPLNNSEVDPKLVGDAIKEFNGTSKVVFDGLDALCLLHPFIKVTVDAYKNVLTLVPEKKDNRRVAWLKIQMRETIAVLFQLRHIRDPDEKLVDGFSIQDRLSGLVEQIAMDIEEMGSVCEAYLKKGFIAKILHHQFWDERLSNYADVFNENRRLLRLVFDNHSYMASTDAAKPNLPLTKEYYSALAIFTKLSTPKEDKTRKFITEKRGARVCIEDDQLLAELIRLSGEGFAGVTLEHTGDSSKDLAVARRKLLKELEEDLDMELSRNLIIFRRKLEMLDGDFGTLFLEEDYVSHPLSTRSYDRVIDKDLRAVWKSLNWKGSVKARHFIIAVHDYLVDKFMADSFSSQRHLEPSGSRVVRRQDDRWTLSYINIAYAQTILEAIDDDALGVVTVKGVNTLFLARPGGWTLSQWIAYWAAGWHLGIDNYRRKIYQLIQEMMIASKKIHPSNRRYVHEYLAHDTFNRIEQLLRSTKPASHDIRGDINLMKLTEAFIDFEEQRLDERLQGVAYEIDAVSTVSLLTGTGKIEKHIYPILYLLLKRDLGILQLARKNILDPDELWDRNLALWTLFSAFDERIKELSDVFRNRRKRRTIEEQLQVHACGMMHLSFAAPERDPVHNTLRTWTNELDDDEYDDFDVASPLSVDFVDSPSDYGSDVDSPNPEKKLSVDILKYRNRNELESTVYNFDCETFSENHDSSVDGLEGAWAGHLWNDDGEEVVSAQGLVQLYLDAPDKEGNIKGNAMTYSGDITVTGTIDKENNVTLTLEYEDGFSTYCSGTYDPASDTITGSHEIDEVYYSDGFVRPTSLQLTPKTASTETLHSARPSAKHKHEDIDPNVSAWYYSTEPDDDVSPSGEEEDVVDPEVVEVDDKDGGRKPTLKVRVSTDLKKYTYSAGDEEDGEDGQTATEVVEVVKTHIKMGSSSSQHVATPSTLHKTTRTFVFTRSPAVAWRFRYSDAQYTDNPARARWKFACAAVLDGVQRRQFSWTWLAKRFQERKRFLELGIRKYLDRGGYSPRDPLLAFEIKELQLLKQNLYPTDAHFYHSLIPFIIDTQYTSHLGRLCSSCNRQILQEHLLCIRCISDDLLNTTDLCQLCIDKTTIHDGHAHHPSHSLVKLRRPLLDADLAWIIPKAREVSDRVRELFRTKGEFIRELAINQKRIGGPVTSSRKFKASTTCGSCGIVAMVPCWVCLNCDPDTFICSDCESRNLSSSPDSPCPSHKSSHILLSIHDTSPETVAASDVSHDSHDSEQYMVLKKRIACLESRLNDESDERFKELESRLMSLEKSFDKRIEDMEGVLKQNLTSTAGGQVKEESSSKRVGPRMGPRQPSLKPRSGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYG0</accession>
    <name>A0A8H5GYG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYG0"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="489" mass="55760" checksum="D79C325A154B9A9D" modified="2022-01-19" version="1">MPTRAAVLDAYSVLQVQEGASFDEVRSSYKQLALRLHPDKCKDVDATAQFQRLGDAYSLLTKFLTGPYQGLYDDDYDYDDDDDDDYDDYYDSEDELAEMSFYFYLFEQAMKDRIYGRSRAYFRRHHGPFERERAPQETPEQYAERLRHSREEQENAEARRKREEAFRKERAEQDRQRERAAAEKRQKAKAEEKKNQAEAQRKEAEEAARTRRQTTQNKRSAVFKAARAGKADVVKKGIYDDNVDAAGGEVIQGYEEFVMKRPQDNQETLLHIVARNGDHELVEWLDAHNADVEEKDSKGFTAFHIAVQCGHIDVLNYFFKNHSPKEEESEPIYLSPKSTSVLLLALQSHEPEVVWTILNNGLASSRDIDGAWSWINSVDGKKAMGSSSKKVSGAQGKLDDILQLLMRFGSFTPPPSPVRNAKEKDGQAKQRSPNTKNYNDRPGPSTAQPTPSSSESSSTPHSQPRNGHRGRGRGRGRGRGRGRGYYPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYP9</accession>
    <name>A0A8H5GYP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_000784</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYP9"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="47"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5373623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="759" mass="85277" checksum="AE4227CAA92724EC" modified="2022-01-19" version="1">MSGTLTLSSKLSPFPYGILAIATCSEAIQVVYDETITKPVLEIKGSKVENEDEIVHALATAAGVVEASPSAASFLALSKTLPTASALPDIMSALESLDDHLAWRTYLIGHEITVADWVVWGAMKSNNKLMGLLKNGRHPHVLRWSNHLESLDSTQAAFASLTAAKASKARSTKVAASFALGLEGAEMGKVVTRFPPEPSGYLHIGHAKAAMLNQYFAKMYEGKLIIRFDDTNPSKEKSEFEETILEDLELLDIRGDVVTHTSDYFDQLYDLAIKMIETGKAYADNTEREQMQHERREGIASAHRDDSVEDNLKHFAEMKSGSEEGLKWCLRAKLSVDDPNKALRDPVIYRCNVLPHHRTGDKWKIYPTYDFACPVVDSIEGVTHALRTNEYRDRNPQYWWMIDALGLRKVKIWDFSRLNFIYTLLSKRKLHQFVNNGQVRGWDDPRFPTVRGIRRRGLTVEALRQFMLLQGPSQAVVSLEWDSIWALNKKVIDPVAPRHWAIVEDKKVSVTIKGGPASPEVKTLPKHKKNPDVGEKNTVYSSNILVEQEDAQSFEDQEEITLMDWGNAFVRSKTTDSSGQITSIEMQLHLEGDFKKTKKKITWLAQPTSSHPLIPVTLLDYDYLITKKKLEEDDNVEDFITPVTEFRESTVADANVKELKKGDIIQFERKGYFIYDGEDKNEGRMEFIRIPDGKAANLASKAGAASTPANKAGAAKDDPTKIDTSSVTKMYKLEPVYGEQVKPDVDATKMYKVDNIYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ34</accession>
    <name>A0A8H5GZ34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ34"/>
    <dbReference type="OrthoDB" id="2983908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="520" mass="55483" checksum="CF4211E4B9B8AF92" modified="2022-01-19" version="1">MAPSKNEAITDIPVPVPDSGSVFRTTLSPFFQSTTFTATSLKSSATSSSRSLTSYSSYPSTHQTLSSPYTYSTISHLQAQTSSSISAASSTAVSRTPGSTTSHKLPVVIIALIAVGSAFLIVTLFIIGRACTRPTNRARPKPSLPILEDPFDDDVYKIKESPLFGGAERFSSQTPLENPFETPGKPGVSLAPPVPALPPIVLDSTNELSPMVANRPAPSKSVPNIGPVGQRPPAARTVPNRLSVRSLSFYPTSPVPSNEKAYTADGHHVLDRNSKALLRTQSRFSVGTRSSSVELAYDGVDVTSPQFLAQYQEAPLTSTAGRSKVKSSYYTPGSYPRISSLPSTSSKIKTDDVDYPLFDLDQLPPIHPALASPRTMETVPLSPQPTLTTLGPDDSLSVVEKRPVKKAVPFNSESHIMSPTMDTSTVLGSLMLADFGTTTKSLSSRLGESNGDLAKGRTGLHSDRPPRVPSPPALPSLAQMGLENMDPVAYASYRSPTYSIFGMYEADRKSRASCGTVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZF3</accession>
    <name>A0A8H5GZF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZF3"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="12097" checksum="DE083509E7FB07DA" modified="2022-01-19" version="1">MFIRTLKRALNSSYHPYSTFSRPAPPPLPREQQQEFEDLQRAAQTPSSLPDSEADPALHPDARKPLKSNFEGDTNPVTGEQGGPKQEPVSRWGNSEGDWSFKGRVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0C8</accession>
    <name>A0A8H5H0C8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0C8"/>
    <dbReference type="OrthoDB" id="3358294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22211" checksum="6C5916C3A4574ED9" modified="2022-01-19" version="1">MSSMTYYDNAQASSSSLPLPAPAVTQEPSTTQPIDSSSLGYTFSLSRSSTHESRHDRRLSLSDLETQNAERDLELGMAPPAYEEPPVYTKTDEPPITLAMYLFKFGFLFPPFWILGACILFSPLRAPEPAPAPASNSSLDSASESSFTDAWLPEKTAAERQAIIDHMRKAELKWAWRCLWALLVVAFFGVAAGLTIFAVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H138</accession>
    <name>A0A8H5H138_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Developmentally regulated GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H138"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="279"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5374884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37038" checksum="CC5B4685A682465C" modified="2022-01-19" version="1">MGVVEKIKEVEEEMARTQKNKATSYHLGLLKAKLARYRQQLLEPQTKSGPAGTGFDVQKSGDARVALIGFPSVGKSTLLSKLTHTQSESAAYEFTTLTAIPGVIEYQGANIQLLDLPGIVEGASQGRGRGRQDIAAAKTADLIVVMLDATKSEEQRRLLEIELDAVGIRLNKTKPDVVFKKKTTGGITFNTTVKLTKTDEKTIRTILAGYKLHNCDVMIREDITTDEFIDVLIDVYNKIDSISLEMVDKLARTPHTVVISCEMDLNLDYLVDRMWEELNMVKIYTKKRGAHPDLTDPVCMRKGATIENVCNSIHRSLAPNFRYALVWVSYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H2K4</accession>
    <name>A0A8H5H2K4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_000346</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H2K4"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="18">
        <location>
            <begin position="190"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5375255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="530" mass="59815" checksum="17DCDE8965836E02" modified="2022-01-19" version="1">MSLARDDVSARILQGQHILIYNRHVIRVPGAWLANHPGGDLAILHFVGRDATNEIDAFHADTALILRYSIGQLAGDEPWQPLLPPIACGWSRRDDQWLSSASTFHPDSAQVLLVAKDSPAIAPTLATITPPPSTLSLQVQHQHAQAYKHLHKRITDAGLYHTPYLSGYGPEFLRYVSLALVSFYAFRTGWIVISALALGLLWHQLMFFAHDLGHMGVTHNWTYDRLISILIANFIGGLSIGWWVDNHNIHHLVTNHPSHDPDIEHLPFFAISPKFFTNLYSSYYGRILPFDFASRLFVSVQHKLFYIVMLFARFNLYRLSYVSLYNKAFDTKRSRGGKWAWRLEMIGIIFFWTWFAGLVLRNCGSWQKALLYMVVSHVTTSPLHVQIVLSHFSMSTIDLGPTESFPARQLRTTSDVICPESVEFLHGGLHLQVAHHLFPRLPRHNLRNASIMIKEFCKEEGLTYAEFGFVKGNQEVIGVLREVAGMVKDIGQQIKLVADVASVEAREAVNKKMAQGETSDNGNGVLLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LEN0</accession>
    <name>A0A8H5LEN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LEN0"/>
    <dbReference type="OrthoDB" id="2836053at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="368" mass="41946" checksum="47E93B1E979A55BE" modified="2022-01-19" version="1">MISPQLPPEIVEKIILLVWKNGVLSSDERVAFMTACPRLNRTWNAQFARIASKEIYLPKLSYLLYLANIVRTGKSLIYDPEDLVTRVETMTCFLDLRSYPLSWDKSTESLYFMLTNMGSFTSFRSCFPSVKELSLEAVFRTPPHLWTTDFPQIMHTQVVIPFDTYNPTTPSDALIHHEIHINAAIHDPDAYLGITNALWNYRSNPLSDYLALVVRVISGDLGKSLQFCGPLGSSGDRPHTCNVLRMRNRLHKSRVLSDNVHLFHCNAIFVETTTPADLFGVSQHLWRSGRKISLSWDSLRNDLCDLMAKLWTRTMGTGMVKEGDWDWIMPVKEPQMEKGLLWNKAEAPFSALDSLHDLIKDNAPVMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJZ6</accession>
    <name>A0A8H5LJZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJZ6"/>
    <dbReference type="OrthoDB" id="2525765at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="741" mass="82873" checksum="F2D0E6749D232340" modified="2022-01-19" version="1">MSPESSTGTLETTIKPKSRKPPACDYCKARRVLCHPEPEGRSCPRCLEKGVKCTTTPSVRKRRRTQREILATKKGQDTASNGDTANEDGVHARELITAARDDAKTSHGQELTASRSLAQYAPHTHMLVNCAGLKDVYRRPIAFAPVSCHPQLQLPKRLMQDLFNDFVHTPYYFHPIIPYDRVRARLAGCGWQPSSLSPQECVLVYCIFALASMVSTDPLIIGTEPLPKECIKILTTIHPVKKIKRDLREIGRRRESAGLCHQLRAEALRQAQNEGIAVWVSPENAASCSLLDVLVSQYNGPNPYSAAFAWQARRLAESWYQHPQRYNWIFGTIDLSIRWAAILMLDVLEALNSDRSVDSSAHDEQLICGHDQLSLEKLTRLLSQGCNSWQFYGYYLSNYTPRKRVNQPPNSSVPVTDLIACARGRPYDFQVIKRYAASLHVLHDVFNAFNKCGVLLARQNQGQSYTILALVRLASIGWTNLTLHFYKTMKEMLEESSVTDLYAPMSGPHGIDIIDGLDGYRNGDLDGVNGLERGTYSYSSLELAPVFLAVRTLTCKAAIEFSEMIGDIYPISRLAQKKIVGGDLKRWVEFVIDVPDEGVMSMSEGTQTLERLRDGLKIAGFAWTDYTDLVEVIDSHVSALMDNSAPAQDPTHSFTFDHNSDHHHMHLDPHCDSHHVPQSGSVNAAHLDLDYNPDIDRHNLDFLNSSHVPSADVPPGAGILEYDPLFSGYTYASRSSDFFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK43</accession>
    <name>A0A8H5LK43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK43"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5360084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17678" checksum="C064957B5D407645" modified="2022-01-19" version="1">MDHEIQNLLMIMSNSIAYLTSRANFLEISPEIPVTKQRNPEKYDTPEVFEGVFVVAWMRYGTPLVDMLTSLHDSENKKELVTDLVRKAKQIEYLISSLPEPESEEEQAGRLQSLEEEMQAANVQYIAAVNRAKTLHAQISDLLHTMLTEVDTDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL69</accession>
    <name>A0A8H5LL69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL69"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36895" checksum="9298BDDE24EBADF2" modified="2022-01-19" version="1">MQNQSSRSGRESATRGQQNPNFTSTKMETETNEDSIMSSSLPIRKQSLRITKSDSNIASKNPESTTTTTSTGIPASPVLGSTLRTSTPLLSFSNDHSQPILRVERDDTAADYAMDVDVDMQLKSSGDSSTLSPCYLPPFDINVDADADMDHSDPPWQTPGPEVALSSNLRHQGQSRSRQRSALPIPPGHRRYHSSPSHQPNTLGIYFEPESVESVDHHPRLYRDGTPPVNSDSDAIMAMNRGDDKHGDYSHWHNHDGTARSSTPTNPIPNCYYLPTLPTLPNDADELGLGTGTPSPRRKRVREEMIEREDKHMEEAEGRRNRIGELNRTHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLE4</accession>
    <name>A0A8H5LLE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLE4"/>
    <dbReference type="OrthoDB" id="2548253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="896" mass="101197" checksum="23BF78567078F625" modified="2022-01-19" version="1">MPRWYKSYKQLVGSASQPAATTRYYTYYHFIMQFVASILLGMTLFSGAALGSIIDMECLPSQAGSFGCGFSDPDINNGNAFIFQCNGFNFVLFAAARIAAKSTAEQILRSGMNGNTYITEYRVFKQKFRGKQTLTQLNVGFLYLFTSSTTMSLPDREKRSQPPLHPPNSPRRKPNSVLKCCLWIAGVVGLTIGCVFLHFGYLLLVPFYHDTVYPHQSLYQTSAVSNRSSVVQPLISKEQTFDVAVSVWVRGTKEEEKAWRAIQDTGMDDSQRPQTSLFDDNLLNGDQKMLYYPLYSDIPLRGLRLSDKHVAASIDLSVPTQKFRAPTLLETDLLSTFVLIPTSPSLMDFVVNFSSWKPDEVLAKYPLYRTWPFPMGSEYKGEKTIADLALESFGLQAPLIQFHEIPSRCPSTTTPSDEKESDGDEPEPIDPFGSFDFSSFVTNFDDTAMKTKNHPHVTAWSQLRIVEETHIMNREAYNEVHEELKRTSCGQGSFLKPLRGLCGRNYKLTGNIETRLELEVKDEDGSTHTEWAYAPYLISDRYASGPMDLIPVPVHREDCTGKEIQNTIDNSSSTFNLADSDFMNFTWHISFTGRSPAKFELGSYIGSQPTVNHSQSDYQKVQDQDSVELLNSLRGVRKPDAHPRRRIFLSTIENNTVYISIPGTLFLVASEISSALGDLISAKEEELWAFYAFMVLMVLPSVYLKSRTAFRIELVWKGWIPSFSRMQPTHRERASERLDKSTSWTVRLTIFCCSSLFLLLARGDNLQLLPPLHPAVPQEDVDSPPTTAILSTLAEWSSTLFYDLQTPLWLTGISSQIILNHKSRHFAGNFKSAAVLSFVNLSTLLMKYVPAVVGRYNSREALWFHSFLTWGVQVVIVYQAVMFPEVRMVEGDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLJ6</accession>
    <name>A0A8H5LLJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLJ6"/>
    <dbReference type="OrthoDB" id="2896404at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="276" mass="30534" checksum="317E637BA71C6953" modified="2022-01-19" version="1">MISWMVFDLTHFLLLGRQSGPEPPFGLCLAQASLIYMIPVLASFACAALVLQLYHSIYSLIDIGFSPRLEGRLMYILLFAPCTFGTLVFIEALLYGLSHPEKVMRSNSGMICRITNGIPSKISAAFVVTALVISMVLEIVVFITLYRNWRAFRALNQAPYPSIVRITIAFLLGVVSIIISVILSLQEGKKDQETTLGNARADIIIETSEHIILHLTESELRLTSFVPQVPLSAAIVFGTQKDMLQAWMFWKGSKRPQNVASPTISVSLVKFGSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMJ7</accession>
    <name>A0A8H5LMJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_009578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMJ7"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="906"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5362663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="967" mass="107807" checksum="60F2B253EEF0741B" modified="2022-01-19" version="1">MPEATEFAIKVTSEDPKKKKKEEEEDKAEGTSKPQTDGKKDEKEGEGDELSEEDLQLRSELEMLVERLKESNTDLYRPALETLRTLIRTSTSSMTSVPKPLKFLRPHYPDLQALYETWPASEDKSLFADILSVLAMTYSDTQPRGTLRYRLLSSSLRPSDSPLADPGSWGHEYVRHLAAELGEEFEYRQEEEEGEEATATKPAVKLSGTMDDLRSLAKECSVFLLNHNAEPDAVDLLQELEMIEEIVPLVDQNTFDRVCQYMSRCVSFLPPPDDIIFLQTVHKIYMQFQKFPQAMTLAIRLNDKDLIFQVYQAAGNPLMKRQLAFMIARAQIPVEWLQPSTEENSDGEEDEFPEDLMECLSNTRLSQSFRFFGKEMGVADAKSLEDIYKSHLENTRPGSVNVDSARGNLAGTFVNAFVNAGFGNDKLMVEAEEGNSWIYKNKDHGMMSAAASLGLSMLWDTEMGLSHIDKYTYSPEEYIKAGCYLAIGLVNTSVRTETDAALALLTDHVENKSVPLKTGAIMGLGMAYAGSQREEVLALLLPFIADDGVTMEIASLATLALGFVYVGSENGEITGTILQTIMEKAEREDKSLDEKWARFMCLGLGLLYLGQQNGSDATLETLKAIEHPVSKTAQIIVEACAFAGTTNVLRVQKMLHECDDHIVAPKEDEKKESDKDQKKENGEESKDKEKEKEEPKKRDDTFQTFAVIAVALISMGEEIGSQMSLRQFNHLMHYGEPVIRKAVPLAIGLVSASNPQLPILDTLSKYSHDNDPGVAVNAIFAMGLVGAGSNNARLAQMLRQLAGYYHKEPDCLFMVRVAQGLVHMGKGTIGVNPFFADRTVMHKSAVAGLLAVLTAFTDAKGFILDKYHWMMYFLSLSMYPRFMITLDDKLNHLPVSVRVGQAVDVVGQAGKPRTISGFQTHETPVRLATAERAELATEEYIPFADNLEGFVILQKNPGWEQEDKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMP6</accession>
    <name>A0A8H5LMP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="286"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="797"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5362841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1331" mass="142637" checksum="D940935DAFD735BA" modified="2022-01-19" version="1">MEGVIIAIDRGGTFTDVWAFIPSHLFENPSSELLGNAVISPGQNGVQVQLKLLSEDPLNYDDAPTEGIRRILQIVEGRKILRGEALNAELIDSVRMGTTVATNALLERKGEKFGLVMTKGFRDLLEIGDQTRPDLFDLSISTKPGLLYDPAYIIEADERVTIEGWSLDPQGQTVGGLLKDSEKNGEEGTVEVGISGDVVRVFKKLDEESIRTSLQALYNSGIRGLAVLLLHSWTYPTHENKIAEIASSIGFTQISLSSQLSPAIKVALSSSTANVHALMSTQAVPRGNAACVDAYLSPVVRRYVDNFLSNFVDTKAGKRCDFMQSDGGLVSAKKFSGLRAVLSGPAGGVVGFAKTTYAEKSGVPVIGFDMGGTSTDVSRFAGKFEHEFDNVCAGIKVSIPQLGIETVAAGGGSRLTYKNNTFCVGPESVGAHPGPACYRKGGELAITDANLILGRLVPSTFPCIFGPNADSPLDAEASRTKFAKLTEEINSQRPGTKPYSIDEVAAGFLRVANENMSRPMRSLTEQRGYAASAHNLCCFGGAGGQHACVIAKGLGIGLVIVPRFSSILSAYGIACADSVSEVSEPTTVNLSKGNNATWSTIQERIEKLRAQVSKNLQEQDVEQVTYHVELGCAYDGSDTVLQIPYHGPSVVEDFIAAHLQETSFSMPRDVLGVSVRVRGTGKTVDFTPIGFGDELAAAESAWANGKDVPSPKEAELVSAYFDFTSGGKRVQTLVYALGSVPHGSRIPGPAIIADNTQTIVIEPGCVAFVLSEHVVIRVGNEESSVIKDSEVDIQVADPIMLAVFGNRFMSIAEQMGHTLERTSISVSIKERLDFSCSIHSTDGSLVANAPHAIHLGSMQYAVQSQHQHWLGKLRPGDVLLTNHPEWGGTHLPDLTVVTPVFSPEDTKVLFYVASRGHHTDIGGTSVTSMNPISKELWQEGVSVKSFLLCSQGKFNEEGFRELFAEPAKYPGSSATRRIDHNITDIQAAISANVRGISLMKTLFEEFGTKTVLFYMSQIQTLAAQTVRTFFQDVYKRFEGRPLEAQDYMDDGTIIKVRITIDPETWNAVFDWTGTGPQTHGNFNCPISLSYAAIIYSLRSMIRADIPMPLNQGVLDPITNIVPKGCFLNPTGVVAISGSTISSQRLVDVILRAFMAAAASQGCANSLGFGTGGKDAFGNVIPGFAYGEAIGGGSGAGPGWHGSHAISVHSTNTRLTDAEVIEARCPLLVEEFTIRRDSGGKGRWMGGNGCIRQIKARIPVNCSIVSQRRVFAPFGLEGASDGARGKNIWIRHDPEDQSTAEISMGNNSLVRLGKGDSVRIETPGGGGWGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPD0</accession>
    <name>A0A8H5LPD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPD0"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5364657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="249" mass="27661" checksum="17CA960E791ABC5C" modified="2022-01-19" version="1">MQSALRLARRSAAPHSSLASASVSVSRANAFRCMTTANPALDSSASSSQAGTSYRKASNIVPLSNVEAQWEKMSREDQISVYRELEEIMKKDWKEMTLDEKKAATSTCFSSMSVVTCMRMAAQMPHFSFGSINAGLVLEIVLTYYVSFGPHGPRAPVSKPGDNFKIFLSTMALVGVSGILFYAIRAFSPEPPRTISKEWQEASNERALEQKMNPITGALYSARFLWLCPRAHSPNHNSNHNHRHDRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQN3</accession>
    <name>A0A8H5LQN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQN3"/>
    <dbReference type="OrthoDB" id="2834359at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034181948" evidence="2">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="72" mass="7561" checksum="55097492924F358D" modified="2022-01-19" version="1">MKFTGIFATILAATLAVSALPSPIMGENAKRMAAGLPPLAPVRLRRQVYDPAPSATPVKRQAGYPSAVPRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR99</accession>
    <name>A0A8H5LR99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR99"/>
    <dbReference type="OrthoDB" id="3360976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="22864" checksum="09CD00D736D8ABC4" modified="2022-01-19" version="1">MISRERVFTASDGIEYKWIMGLTSSELFKNDDSKEPVATFHSSSSKLGNGIGNWFKSKPTSKSQNQNTSYLEIHPEGRHIPGEILLTFIYIEQERTREDVDVAAESYASGSNFKRVNVPTDVDTMNLLETHLTVPERVARDSESFVQRIAVSDAREGDVVGGNGKEKKKGKAKKRITVPTDLDDLFIQDLRTSEAVALRLAGSGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSH6</accession>
    <name>A0A8H5LSH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSH6"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="424"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="727" mass="80956" checksum="62745093A24CCCE5" modified="2022-01-19" version="1">MAHLTQVPNGAGPYHHIVIAENALNSKQTVWQAKWHENGARTGGFERNVVVKIASTAEAVRKLEKEAEFYENHLILLQGDIVPRYYGFFRVLRREYACMMLEYCTGSVDPMNFDCEIMLAACKLHSSGIYHGDLSPVNTSSGLRPHHIVSCGNSVRLVDFSLAQAGHRCNNTLYPSQQGMLSNFRNTALNPFSSNAPCRELVALENFYGQHEANQHVPEGWNQEESMRKVAKAKTNEVEKASLLLSMGGTANRRIASGNRAQCNDYVATPEARRLDATRRVRSESGESRVSGSSLTLNHHHPMARSPSISLRGDSAMSSKIGAYGREGCDGPPASFRWRENAVELVDDSIGTKTYIYGQGLRLDSKMIPKILSLLVCASAALPVVFGIDVPPPFNQSFFKDLNVTRGLTYHYYAAPATVGSGKPTLVFLHGFPSSSYDWRHQVSFFQDQGYGLVVPDMLGYGGTAKPLDPQLYASSLICKDIVDIMDAEGIEQAILIGHDWGSKITTRLANYFPERFHAFAFLAVGEISPGFSTDFNESFSVAKAFLGYENFGYFDFLVSEGADQVIQEHLDSFFDAWFPRDTVQAIDSLCPIGALEAFLKNDTRIIPGEYVTSEERMIQKDLFYKDGYSAPLNWYKIVMSSVESDDDEGIPKENTSTQKPVFYGAALRDYCSIPHSTLRNLPRFAKGELIIHEYNTGHWIMLEARDQVSNDLLQWIEGMCLEGCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSM0</accession>
    <name>A0A8H5LSM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSM0"/>
    <dbReference type="OrthoDB" id="10628500at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="621" mass="70037" checksum="E34CE0BEFDFD365C" modified="2022-01-19" version="1">MLRLDRARWIQRQRFRRHCLQSIPIPPSSKSVSICFIHPDDRQSIIVWQPQLQRQTFVPSPNLSSSIFTMNQLFGLLSWVASSIAPSSQRQPCSMADKTLRVALVLLSNKTPARRNLLVPLTIIGLGIVPIVFQFSSFTIFIGRLKDSISIRQRISATFFPSLASDMRTVHHHSPDIETSPQQTSVSESDVTNGTLTNSLAPSTSTSQDSSATNVLLSPAEHQGYRTAWENEMLAHWLTAWMTDTFEGFYISSSEPYVHLAAKINNALRADKLDPPMPVVFASTYYVKKIRELAYGPEFRDVKEMHAVPREWGPEADCNCTAEMMFKWWLVALYLGQMWWEGEGYSLEMMLSWTALPLELLEHTVFCALESFKATDLEFSLELSDEQQWAKHFTKMESHLLDICGWDNLGSNAPKDWDMYNIVHTLLLEVRFLQLPSESRPWVCDYFCESPLLISPCPSSGSLSCQPALCTIADPVEQSDTDTVSCPSRSPPAPAPLPSSSYYYAREKLPEPEPEKQKGFLLHDCSSGVEDEQEVRVKDEAGLAGLSEDDACAEQGQVCPRLSRTHRQIGHARKSRGKNMAIFKTHTQAPSRNSDGDEDGDDYDGDDEFEGLSKKNCRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT74</accession>
    <name>A0A8H5LT74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1751-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT74"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38082" checksum="0CFDC62AC64BF0C2" modified="2022-01-19" version="1">MAILQSPLTFIASIPPVTRYYTLSTVVLSGVYGWLSWNGTYTTPYLTLVPGSSLFYPWTFVTSALVELTFWELIITLITIPPSLRYLERLWGSIETLKFIVVCIGFSNIIAFGFNWLEFIATSQELFLYGMQYHGQMSLQIGVLVAFTQLIPEHQVQVMGFIKARVKTLPMAYLTLSTVMCFIGFQCPWIIIQFGWFVSWIYLRFYKKNTHDTVGGMDAYGDRSETFALTSWFPPFTHPVLGPAGNFVYNTANRLHLIPAGGDLENGYTQVPGSARAEAERRRAMALKALDQRLANSSSPAPSQSSSPPQPQALAAPSPSASSTPPKKNPGETENGDSSVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUK0</accession>
    <name>A0A8H5LUK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUK0"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43610">
        <property type="entry name" value="BLL6696 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43610:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22827" checksum="64716EE83B9D784D" modified="2022-01-19" version="1">MDLASLKLKSRTGRIILVRPTEAHDEAIRELRTHPTIRQYLRFLPETITTEEVRKIREDRADDNTRLDFSVHLVDDSGSVGDFVGGTGLLNTDEVNNHTDVGIWLSPNVHRGGIGTDSLYTLLSYAFDERGFHKVIFETGADNLNMRGWLEKVAGVTIEGTFRELWRDLINGGYSDAVSYGILEDQWRGQVKGKLEKRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWG1</accession>
    <name>A0A8H5LWG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004948</name>
        <name evidence="3" type="ORF">D9758_013075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWG1"/>
    <dbReference type="OrthoDB" id="2986833at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="289"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="568" mass="63311" checksum="305EDBEB3F2CDD22" modified="2022-01-19" version="1">MPPKSKRTSDVFDDEDNASSPEAHHLRRRSQRVSQDTTASKKSKVARSGQKREKQNKTISNAELVRLEKQANELKKLIAQQKQAAATQLDDEDGDEEEDNKFDDDDDDDNSKDMEVEVESEDEPGFTMAGADDDTIRFAAVSTITPMRTITTSAPPHIDLTRIRRKNGKIVPITPRNAYMSVPSSGNGSEHEEPNHSQEETTAANIITPTISRQAGPIQLFQTNNASQQSSATVTDATDTTVTTINNANSGSADSTGQRSTLSFSSDYKPGGKPKAEDYDSEGKAILVRACAYYEAKVLGVKGFPDSSTQIGWARKAFRDACRVAEKDYECDKRIERLLKGRGSRIRGDMLRFVEEAVMSTFGFTKDTSKKAKRQNLELYDALSDDMRFAFKDTTNCTGFAENPVFQLILRLACFGQGHDSPGIVFARFFDPVSLETLALFMTQIHHIMRQWSTGIYIRHGKTNPFSETGYTAIHKKHLHELQLWQELNEYVVTQIRKRMYTRARAKSGIDPPKIKSLITGELQDKIAQELAGRTGDTESEREDDENEEEEEGGQVLQQGQAGDGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYH7</accession>
    <name>A0A8H5LYH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYH7"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48958" checksum="8D7DB94D13A6D518" modified="2022-01-19" version="1">MLAHFAPELIALVIRQLRPCRDVLKACSLVCRSWCHPSQLMLFSRITLSSDEDCRRWKEYIHESPHIATLISEVSIASNVDINTQSVAQDLANLLTNVQCLEIDRFSASLGEEELEFVRRFREVRRLRLNKATWTAQDRMLEIFQAMPAIMSLMLIGSLAGNEGQGHGIEADGSGTITTSSTGSVVLQNLAELVLASVECNETILEFLMSSSLDFSALRSLELQLGHVPESFQLRGIMISRLFDAFLERVLSLPENLVLSLPSVFSTVPYLGQSWRTCLPHLISHRSLASLYSVQTLIIRLPRLGYFHILLAHTWELVNTIASAPRLQKLRLEISFTVNSEPWKGGFNFVHELLEWKFLDERFSDRTRFPCLRRVEIGVGFVSLRQRRHADFEHSTVYKTVFNDLTKWMSGRMPGLHGKGMLHFDMVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTH1</accession>
    <name>A0A8H5BTH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000353">
        <property type="protein sequence ID" value="KAF5328926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTH1"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5328926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="376" mass="40247" checksum="7CDF2A2F29597532" modified="2022-01-19" version="1">MATMRAVVYEKPFVVSIHEVPKPKILHPDDIVVKVTTTCICGSDLHMYEGRTAAEAGIVFGHENMGIVDEVGSGVTLLKKGDRVVMPFNVACGRCLNCEEGKSAFCTHVNPGFAGGAYGYVAMGPYPGGQAEYVRVPFADFNALKLPAGTEHEEDFALLADIFPTGWHGVQLSGFRPGESIVVFGAGPVGLMAAYSAVLRGIRCRPSPERLQKAKEIGCIPINFSQGDAVEQILKLRDGKEVDRGVDAVGYQATTGDGKTEQPNAVLEALIRAVRPTGGLGIPGLYVPSDPGAPDSAAAKGYISFPFGKLFEKGLSLGTGQCNVKAYNRYLRDLIISGRAKPSFVVSHNLSLDKAPEAYDKFDKRIDGYTKVLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXQ8</accession>
    <name>A0A8H5BXQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000322">
        <property type="protein sequence ID" value="KAF5331505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXQ8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="689"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="732"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="775"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="818"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="861"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="904"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="947"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5331505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119398" checksum="E60E57D2EC5D420B" modified="2022-01-19" version="1">MNSGTFCKRLIYKSSDVTERHGSQNEDNNSIVPAAGQPTIGILQGGHHLSMKDNTINVVAGNQDNKAYHYYGFQQDIINKLNPSTSALHEVGQRAECIEGTRKEILDNIMNWAGDGSSTTMTGYWMCGMAGTGKSTIAQSVCLGLKRKGLLGGEFFCSRQIEECHDYHKVIPTIAYQLASRNAKYQQALCDVLNEDLQLASKEPQYQVTKLLIDPWKRVVSRGESPFLAPVIVIEQHIKKHFDLDAIQQERLYVQKFYLHNVEKSIVKKDISLFMGKGLIGLGISKDKLDILVERSGALFIYAATLVKYLAGGGHRASSRLEKVLNVKGSPNRIQTQMLDELYTQILSDSLDKLSPEEKDQSIRIIHTVIMTGTPVSCQIIADLLDYKVQDVKATISELQSVLYTSGPEEVIYTFHASFADYITSKDRAADLHCNAPEHHSVLARGCFDEMERKLHFNICNLPSSFLSDSEVAGLEEAITQKLGGAVWYSCIFWGYHLTEGKKPNVVMEKFLQKKILFWIEAMNLMGKMSECIRTLDLVLKRGQFQEIEQRQHILQCRDMANVFALSVVKEMTPHPFYPAISKSLGKQVKVNTEIKYSQSVGFWDTGSGVEGISVSPDGTRIVSGSEDGTVRIWDAQTGTAIGEPLQGHEYWVQSVAFSPDGARIVSGSRDRTVRIWDAQTGTAIGEPLQGHEDWVQSVAFSPDGARIVSGSHDRTVRIWDAQTGTAIGEPLQGHESLVQSVAFSPDGARIVSGSGDRTVRIWDAQTGTAIGEPLQGHEDWVKSVAFSPDGARIVSGSHDRTVRIWDAQTGTAIGEPLQGHEYWVQSVAFSPDGARIVSGSSDRTVRIWDAQTGTAIGEPLQGHEYWVQSVAFSPDGARIVSGSGDRTVRIWDAQTGTAIGEPLQGHEDWVQSVAFSPDGARIVSGSGDRTVRIWDAQTGTAIGEPLQGHEYWVQSVAFSSDGARIVSGSDDRTGEPLQGHQKFVQSVAFSSSGAQILSGSSDRAVTNLSTGPTLSCKYNNWTIDKDGWIQFPGIHCGIVWIQPQYCPTLCTSQNPVIISRKGCTKLSFDEVVYGKDWAQCFTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZP6</accession>
    <name>A0A8H5BZP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZP6"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5332430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="204" mass="22466" checksum="CD40D656751FC6A0" modified="2022-01-19" version="1">MAAESRGRVGGGRLAVDSKLVKRVVIQSGAPIDRYIPVVLFMEDIGNFPCETYEQRMKRSAEIENWTNGIYRPAPSDYVPTSPRMVTSLVNPTKHSFPAPLDNLLKGGRPSTAYDMLDSSPSSNWKQPLYAPSVKKCTPPDSLSFRNSRSTLVDGLARGTFNDSPCPFPLHKAVPQPPPDYEPFNFSLAPTIAFICHQGASFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C001</accession>
    <name>A0A8H5C001_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C001"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="297" mass="33071" checksum="5A84A29BB625790E" modified="2022-01-19" version="1">MSPLELPPSSAYDSKAQRVVDLMVRVEKIGRFPEAHSGFADVWKGVWKDVHGHERTVAVKVLRSCIGDPKMDDTVQKRLARELAGTVSGFGTYVSMVWPWLDNGSVTRYMERCGDILSMPDRLQILVEVAGRLAYLHSHDIVHGDLSGASILIGNERRACLCDFGLSSFIANFESTTMYSTISGAVRWADAFLYKMQMEEDQVPKPTPCSDIYSFGSVTLEVAYHTTTSVLTLSLWRDCVQCWIYWLLRIIPPVTKREDADVGDSSDGDGDGDRDRDRDEGDGAAGESERDEGNEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2T7</accession>
    <name>A0A8H5C2T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000278">
        <property type="protein sequence ID" value="KAF5333933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2T7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="588" mass="67128" checksum="843425E0DAFE08CD" modified="2022-01-19" version="1">MPSDGDAGETGSAISHPATFLGLPAEVILEIAHHVQLQADKPDVYPRKRLSKSHQKSLVYWNCKCLMPLAECNHHLRSLLTPLIFAKLMFAHSYPSISRDNRLLDVYSHLLDPDYNPIWLKHVRECHIMDWPQSQTGEDDGLIVAVCQALARLRDLDRVQIDDCAVDLTDGVLKVIGDTLYPQHVGLRHSNFSAQELSAAWTRMGLPPSSCTFDLHKHPTAIFDLYRRITYRPCDITFLIRHHFLSASLLTLELTGILVSQIPDLFQILRHAPLLRELLLDELVVARLPSRDSDPEIELHALHLPVLPADALPHLTRLRATPGLLRYFVPVILENSSNFSYLDLSRYYKAQGYIPAPRVDFKSCFGSQTLEGLRELSICIDNTFEYNLGDYFPNLRRLQLRDIAEHESIRLHIQKIASHWPTRMPTGITSFLIDFMPRRDGRLEDRNTELEFDLPSQLDGIKALTRVMPNLTWFFCGEPVEWIRRPRVLSESTSTDNSSEGEDWHPSLVPDVGGELHKFLKAHLIQMWEWSFHASKRWNSGMMVGPRPRAIRDYRGCLRSMFGEEDRQNIQILAGKLGVAAGSILDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3W7</accession>
    <name>A0A8H5C3W7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3W7"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="379" mass="40859" checksum="68B70EB524A72C12" modified="2022-01-19" version="1">MAVPKTMQRYILTSMDESFQGLTLQENVPVPAPAPGQVLVKVHALTLNARDVQIATNTYPNPAQPKKDVIPVSDASLSVIAIGPPLPDGEPIKWKIGDRVLPNFTPGFHAGKINHKVVSAPTYGGGRDGFLCEYQVVAAEDLVSIPSYLTDEEACTLPIAALTAYNCLYGYEPLLKAGDTVLLLGTGGCSIAGLQMALAAGCTTICTSSSDSKLARCKELGAHHLINYRATPEWEKEVRKITGGRGVDHVIEIGGKDSEFIVPTPASTVSYIGSALPKSIASCKMGGVVSIIGYLSDYNDKRSDSQGDYDVAKSILFAGCTVRGVFVGSREQFEDMNRLYEVKKIRPPIDKVYSFEQAKEAFHYVAKGSHFNKVVIKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C461</accession>
    <name>A0A8H5C461_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000254">
        <property type="protein sequence ID" value="KAF5334701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C461"/>
    <dbReference type="OrthoDB" id="3268838at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5334701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="591" mass="67233" checksum="7C747FCA275A9973" modified="2022-01-19" version="1">MPEQREGTCMALQIRSAIQDKNLGPILGIHADPTASERKKAPGGSCSAVKLGLVTRLGPHCRYKRGTNGAQTPLWPEVFRVTRRNPVPPPISTLSLRGPEAISATARGLDMELGPLNLYLAFLTHTNVQLYTWKQFLQSIAKLPVKVRRFSIRLAFEFQDYFLAFVTLDNVFQPNWYLPSGPIPFELSIPDPVHTWLTFLDQVTQAIMARVNSPSCQRDQVLAIQVVRDMKIFHGIGIYVGLETFVMAGISPFLTEAEVFDCPSRTARLCLAYWEFVNMSYSPELWEKLLRPAIHRGVLAPTVKQRKNYADWLVVYGKDRIKCTFREASLIDKYIHIINSIHQDGNHGIFHVRTGHEASLFDVFEPARIRKSLKPDSQPDLGHLVFGNRMWVQLGRSVPSVLDPLTHMFQSRGLGDGAPTYLLEEVYTSLFDDSRAFFRPTYSYHDRHQIWTMTPVFPPNSFPTSEVALNWENEYSMTLQEVLTKQAKQNSRSTSDQRHCLSSELGDKQERKVLVLCWPPYSSRFRIVEAHERESKLFKNIVSKNTTDVAIGPLEYCGNGRMVKDSHGKLILTVCWYDPGSLSKGLVSREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C659</accession>
    <name>A0A8H5C659_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000254">
        <property type="protein sequence ID" value="KAF5334702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C659"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="529" mass="60194" checksum="2357FDF762ABB623" modified="2022-01-19" version="1">MLILYALARPLLAPDTAVLVNDTFATTDGSGFDHCNDIQRNCRTTEEIIYSCIAVVFICIWVAIHPNIPRKFSWSGREIVSNSEYPAVRSAVVTLQNILFMLLALIVPELIIMWAMQQWFAARAIAKKYAEKYNWTKTHGFFVVMGGFALYDRKKYLCTLEDKEWFTKKDRAAAINIDGKLEDVFIKGHLKGDEDQLDFEEERQAGEEGRQAVEEQADETEKLVIQEQAGEEQVVEEEESVGSTVYRLPDGSASCLLELLLQRELISVTEDEIKDRGKSDALSKFLAIGQTAWFIVQCIARGVEGISITNLEILTLAFALLNFGIYFFWLDKPQRVRFPIKINYQNQSSKEGGTARSVWDWFQAIGWEIRSDWKNLHDLNYPLLAITYPLWTLFIQSRNLVPGEPHYQSGLKKDPTRLYVPAISIAVILGAIHCIPWAFTFPSHTEQIMWRVCALVVTCFPVMGMFLLFIDDLYESTWGFCLLIVGGIIGPIFYGIARITLIILALMELRALPTSAHQTVEWSILIPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C950</accession>
    <name>A0A8H5C950_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C950"/>
    <dbReference type="OrthoDB" id="3066004at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49458" checksum="C384551CE3A2F655" modified="2022-01-19" version="1">MTSSSQHYSSRHRSPAPRVNNPKQTTRAQSGSRNQSRRGSPRPQEYVPPAPDLHCAYQAHVYDFDDYIDCFWDIESKEFYRCNKTAHPCPNRYNSIPLPPKANPNPWRRHINRGQEPLINSHRERTAPPPRNPLVLPPPGQPREAAPQPSTSSDPQPSSSSVPEAPEQPLKRDPTPPPPNPPSQDPDPNPDPEPHPNPPSSPSPPSNPDPDPSDPDNTIDSDSDSDNNMSKATKAFDKVTKLEKDRSNWSTWVTRVQRAAGSIRYNKYITTEPTSAADQQQQDKDLLNGIISTLPDTIFRRYKNKPTSKELWDALKQDYDAKDPLTEASLEKRLFSLTCTNPAKVGKHLNNLITIMDELGDRGVSIPDSQFKLAIISSTPDMYQATVKALITVYREEPSKLTPEMLIAAICAEAQGKNFASSSNKSQESANYSNDNFQGRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9W3</accession>
    <name>A0A8H5C9W3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000213">
        <property type="protein sequence ID" value="KAF5337623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9W3"/>
    <dbReference type="OrthoDB" id="2668963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="355" mass="40001" checksum="4BB5F4DF6C7EC4AF" modified="2022-01-19" version="1">MVGQAESITKRQHKKTELMDTLYAKAVTLYQAEHGPGVTEEVLGRKLHSLRKICIIVENEHYEQTKKALPKHLSSSTLLRLVNGGTPKSLSNSSWGWLLQSEEKIVIDYALELASRGFPLTHQRLKEIVDKICRSRLGDKFSEKGVGRNWTTCFVEKHSSRLKMFWSSKLDTKRGQAVNPFTNEEYFKLLKEVLKGRKDHEFPAAVVDTPWELEIDWEEILIPALGPDDAEIMLPEIEESRKEAAKGWVDVDETERVDAVGEDEGEVEQLEPTPINKDCIYGADKSGFNEDDGAKIRVIGARSKKMQHKQGGGSRENTTVIVTICADGTAICPTVIFKGKHFQVNWNQDNPTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA55</accession>
    <name>A0A8H5CA55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA55"/>
    <dbReference type="OrthoDB" id="2334691at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="18182" checksum="CF56970FDDD8A945" modified="2022-01-19" version="1">MIDQASRIWRIRTDRFYLHGFSGGGQFAHRFLYLYPERLAGVSIGAPGRITQPDTNTSWPGGLGNVESIFGIRGAPNYAAIAQVPIQLVVGEDDRNTSLLQLAKKRNKAEAEAENRVERIQWLKSTWEEYAIGSELATVQGVGHDGIKCLAPVEEWFVRLIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBT6</accession>
    <name>A0A8H5CBT6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBT6"/>
    <dbReference type="OrthoDB" id="3059808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="43786" checksum="19B7D95A347DB540" modified="2022-01-19" version="1">MTHASSSPSSFPSSALQDASITFFSSVEGSCGIDSDDPQFGIQNPHSPTSSLKGVFVRSRQTSTMVSCTNGNCDGEDRLNFAALAGLLNQTIVTGEGSAADLPLDCHVSAKACGCGRRAPSLSRRTTSRFLGHAVTSSADATTATNGSQRTMRTARTFTLEPVRVVRRMNDARSLELARYGSEEEARDRTGAEAEQDKEEEQKTMVKRSITWKRTLSGFLERKDSKKEKEKKNQANAGQADKPEEEPIPPSPAPTIGNEVVLTSADIGPVTVTARTLSLFHDLSRPRGRRSKSLTLPLTLGSRRNQGGEELTSGVNLQQQQAHDAKSNEIKLTEEATAPQAKTHRPKSLSFSGWERGDGNNHHNRDDERDEDDQEDEELDELTREAKGVAWRVGKEWGYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBZ4</accession>
    <name>A0A8H5CBZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000192">
        <property type="protein sequence ID" value="KAF5338688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3056903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1247"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1673"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1680"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1700"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1733"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1754"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1766"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1781"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1804" mass="203763" checksum="1C54D9960F1F5737" modified="2022-01-19" version="1">MRKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPPEEYLGNPDSGEEKDNGNASDMDIDNGELGCPEVRTMPPVNESCEDKSGLQHLPTRRDETQLQTLKLFNFKSIAKAMQPSTIPTDQQSNVIPSKSAVVPSVQSTSHSVGNLQKPLCPPTTVASQTVPPSSSHPPAVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATRNCKGNNGKKNQKGSIHATTIAGGKESYKKCLGVLRCTNPQCQVITRPKIEKKILEAQCLNEYCICGFSLEHFDCGAMSFLIEYAQVGDDITTRLYRYIHAGCHNHPRIPYTKHLTAQEAKDTRQHLGNNMHKKHLESYEGGETLDGPTPPAPQLAQKFANIETYRYETKKMTKGATAEVGWSFINQFHSWIQQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAELVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTAVIEAIAEAAHEHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTELENAAQSLIKGCRYHFEKSVTHVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQQKMDSKLASKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDRSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMYKGSQAAVKAITKLRVLGPHLPPGKSQQQDISNCLGGRLRTGSSQFSTYPQWRFHRKSRVAGDATQRRAPMIQTSIAMGSARKWSLLAGYHLYSSSDQVWMKKAINQIGISLVNYTQAQKPQVQEMEWYTNLWHACSQTKHTFGGQSAVFSYDGMENMGYSQLVKGKIGDLLAGTTGYQPDGYQTVCAVYSLKGGIVAQEKFHEDCVKIALQKLDLQLDGTRSTTLTKPGYREMTREETVNWKPHISITEYQQTHSDSRQVVKPEPAHSYSPSPGPSPTTPLRTIPSSSPPPSTPLPILCRCGVENDGHRELIKQVTVQCDKCHRWSHLACLVNRMEPTIKGEFLCHVCDPASMLDTSSSQIIESLKQGVQLRANVAKRLYAGRTVLVQMDANTLFYYPGRLLHQEKGKWTIKMWRGIKHENANKVLENISVKRLVDGLYGDREGRRSIRLGRFIRTHEERDPADIASDWQVYQYNTEVDRALYKHKAMLQKILHHTINSEFSALSVSSVPALALYLNEGNPGYAIFRNHQYMTAVTLFRRPCPAYFTGGITTDDQARILNWLHINVQSFLSAPPKDFELCIAHARTLFLAHCHRETFLGCIEAGLSELEREQSALHQAWQRLVDFSGKTVDGKMKRLKADVDREALQILEKVMFDRSQKAGVAGSEQWGLDVGPPEDLWWPYDGPEKNDPDLRVATESDLEESEFCKAEREKMEQKVREKEAEKQNHAPPRPKPRPLTKEQAAEHSKKALQEAGLTAERPDLAKEKVVKTLQTVQENAQLRRSKRVADQTKETEETENNKKSKKQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG45</accession>
    <name>A0A8H5CG45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG45"/>
    <dbReference type="OrthoDB" id="3112770at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5339922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="145" mass="17159" checksum="7E6B6A1054AF849D" modified="2022-01-19" version="1">MVVRDMLLYISFIHRFRKFLVFHDWVVRPVSARVKRDAWVYVLSFRNGKACKIGCTRRTPRRRLQEWRCKDKSKGFKLVYSVRVSEERMFGIGKNAAVDEEEEAIRTRLEAIGLHVGANFAERLCRDRSLFTETLDVIKFVCKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJP2</accession>
    <name>A0A8H5CJP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJP2"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19195" checksum="E03611F415F3D671" modified="2022-01-19" version="1">MRLGELVWPDTIAHRELRKVVMRASLITQPDHIAFILPTHKSDQQFDGNKIVVKATGEEDCPVKLVNRYIESRDHLFPAHPNLFARKDGSILTRQWFIRRLRHYFPEDVAGHSLRSGGATHYALEGYSWEEIQTLGRWSSEAFRLYIRKHPLFFTALLTKRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJU2</accession>
    <name>A0A8H5CJU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_011141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJU2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5343067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60082" checksum="E18362591E69DC5A" modified="2022-01-19" version="1">MDFPVIPGSWQALGLVTLITLSVHLFFQPKHNLPPGPKGLPLLGNLFQLPQFQWLRFTEWKEEFGPIFSLNLAGQTVIVLNSHKVTADLLGTSIHAPDIRVFLMIVTPDRRSAVYSDRPRFIMAGEILTGKIFIAFSGYGELWRKLRKASHEGLNVRASEVYQPSQEKEAAVLVDNMLKDPISWDDHLKRSAASTILTAVYGMDPIKTKDDPLITRINDLMHRLVRATLPGSFLVDIFPVMKHLPEAIAPWKKEGMEWHRKDTVMFQEFMDGVRKQVNAGEAKPSFAAGLIEKKKTHQLSTKEESWLAGTMFGAGAETTAAALSVFILAMRLYPNVMKKAQAEIDAVVGRDRLPTFEDRKNLPYIRAIVKEVLRWRPVGPLGLPRRAMKDDFYEGYFIPKGSLVIANVWAMNRDPAIFPDYDEFRPERFLDKTGTLEIVPPDTHNQGHVTFGFGRRICIGLNIANQALFIDIASLLWAASIEAAYDETGAEIIPSRTECVDEGLVVRPVPFHCKIAPRSEDVDAMLAMAKKKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLU4</accession>
    <name>A0A8H5CLU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLU4"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="4"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="320" mass="35569" checksum="5DF494FC8069E005" modified="2022-01-19" version="1">MPRIDVHHHFFPALLEKAKLNETIGWRTPEENLPWTPEISIKSMDESNVDIAILSFPAISIGTVGEGNRTQVRKVNVMAADICNKYPTRFAFFASLPVLDDVEGGLAEIAYALDTLGAQGIAMPSSSGVGSDAKYIGHEIYDAIWAELDKRGTVVHVHGSQTPSSTPHPDPFLGLPIVEVPNETYKAAAHLVVTGRKRKYPNVKIILAHMGGSMPFLYSRVAVLSTHMGCQLTRDEIIEDFKTFYFDTALSGHESVLRTMDSFVDRNRLLFGSDFPAVSTEMATWYTKNVEEYYAGDQNALDDIMYKSALKLFPTLRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLX5</accession>
    <name>A0A8H5CLX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLX5"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034623554" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="57980" checksum="193FD9295733CEEF" modified="2022-01-19" version="1">MRRHSFTLLSLCWILPIIYPSAGAGVAGITAAQTLSNQSIHDFIIVERNDYIGGRVVHTNFGFQPDGTPYTVELGANWVQGLGSEGGPENPIWTLAKRYNITNHFSNYSDILTYNETGAVDYTDLLDEFEDAYSIAEQTAGVYLTDNLQDTSMRVALSVAGWKPKKNMAAQAVEWWKIDWETAQNPDSSAFVFGIADFNSTFYQFSDENNFAFDERGFNAFIIGEASTFLRQNDSRLLLNTEVKNVTYSSDEVIIHNADGTCISASYACTTFSLGVLQYDVVSFNPPLPTWKRTAIESFHMGTYTKIFFQFNETFWDPDTQFFLYADPIQRGYFPVWQSLSTPGFLPGSNIIFVTVVGEESYRVEQQSDEETQAEAMAVLHQMFPEKNIPDPIAFMYPRWSLEPWAHGSYSDWATGVTLEMHQNLRANVDRLWFAGEAYSAEYSAFLQGAWFEGRDVGSRIAGLLGKECTNEDVNGNSAGACGPMKRYQVLHGTTREEEYDIANGWSASSFLTFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM92</accession>
    <name>A0A8H5CM92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_013248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM92"/>
    <dbReference type="OrthoDB" id="3047174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="119"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5344330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="580" mass="66559" checksum="AB745480BCC77333" modified="2022-01-19" version="1">MPYTPPLLETHPLSNPRSPDPASRTSPPDSQTQNWNERPSQSQWRIDEDGWYHHTMIDGPGADAAESEPSLASQLPFVDGDLTDQRHDPQPRHSLPRREQRYQERILRKNTKAAVRIASLNIRGYGNPDVNHASNKWNHINQLVKQKKIGMLLVQETHLTKECKEDLEQRFRQLKIFFSSDPENATGKAGVAIVLSRRIANVNGTKIVDIVPGRAMQITTNWHKEDKITVLVIYAPNVSEHEGSENEAFWKNIQEFYETHPNVRKPDVMAGDFNIVEAGGLDRIPARSDPEKALDALDNLKLMLNLKDGWRDTHPATKLFTYIHNPNCETSPQSRLDRIYVKPSILRTAREWKIQPTGVPNADHQMVSVQITTASAPNIGKGRWCIAPHQLKDTKLIKMIMEEGVEIKKQLFALKDGSRSPEMNVQLLEHKWKTRAKEIAHNRAKIAIPKTLLKIQKLEKERDEIANDPNVSEEDRQKNLHAIATKLVHVKRERHEKLRLSVATRDRIEGETISRYWIQVNKEQKPRELIYALQKPDQHPTNTDDPLPGTAYEKDSRKMAEMAKEYHNNLQDQVAHSDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPU9</accession>
    <name>A0A8H5CPU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPU9"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="165" mass="18533" checksum="69D6FF0E30A94B10" modified="2022-01-19" version="1">MTCVIQQIPVEQTLSLRREVLWPDMPLEKVKLPEDSDGWHFGAFLQDVEEPVAVISLFRDALGPVPAVPEPGDSATGSTTARFRKFACKISHQGRGIGTALLDYTLQFARTELGAQTVWCDARTATSEWYEKRGLLPFGDRFYKGAVEYLRMRIDFSTSETSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPY4</accession>
    <name>A0A8H5CPY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPY4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="231"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59451" checksum="D382DFA89279087D" modified="2022-01-19" version="1">MPFRLLYLMRLLNTKTLKLEEFYADIPRYAILSHTWEKEEVTFQDIQNLETARLKAGFAKIQNACARACRYDFEWIWIDSCCINKESSAELSEAINSMYQYYEDAVVCYVYLCDVSIEFHPRNPESSFKDSRWFKRGWTLQELLAPHYVIFLDKDWVRIGTRWTLRDVVSAITSIPVEVFEGGWDINTYSVAQKMSWAALRETTRPEDQAYSLMGIFGVSMPPIYGEGGAKAFMRLQQEIIKISDDRSIFAWVAASSEHDGHRGLLARSPYEFRMSGEVEASDSDFLGDRSSYSFGNNGLHIHLPLETTVDSSRGDDVFLASLLCHSERDGSFLSFYLQKTSRQQYVRCYPDQLAFRPTLQPALNNIQELTVREVTVTRRSRFDAEVHSFDPVMFHVDLLPSARHFLNLCTDTLSSSVVHSPNSSRVSVRLEPGLLHQLIYRTQGTREAFTIRLSYPWRSDLPYYTLHLGGQPFEEYSLSTDPLSTDPLSTILCLPILEMMGQWCVWAVVLSLSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ04</accession>
    <name>A0A8H5CQ04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ04"/>
    <dbReference type="OrthoDB" id="3267843at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046616">
        <property type="entry name" value="DUF6729"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20499">
        <property type="entry name" value="DUF6729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6729" evidence="2">
        <location>
            <begin position="195"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="680" mass="76190" checksum="01E8D8D575DBBD10" modified="2022-01-19" version="1">MSEKNTRGRPLGVPNKPGHSAGGARPNAGRKPSQSATSSNKNSGGIPTSLPNVRKDTRGVFPIFNMARKSQDTSSTQDNSTANPEAGGSNINEFDPQRPFSFLPESTFSESLHSASTDDQETSGKSPEDDIPADDSEGIITTYLHSVKDRLSKSLTGDVMPFCYRENSFWVRKPDPIFAMRNAAKTDEGLNPTPLYLPDVFTWLPHTIDRRPLTCQNKNCNRYQDPEKRLKDKGWPDTPIARKVIGLECNYYIMTKRFHCAKDASGGCGRSWMLYHPDILKQLEPALADRFPAFLTHRSAIDKTLLALIRAGIVHHISSSAWEEILQELHVREHDIRELWYLQSIQHERMLDAKWQRPVKQYRPFSAFNTKSQYAGYSPSKKFITNVYLDFMENIRVCLDQCVSALPGLILQWDHSFKVPLYMMHLNGIKIFVALFTVLNEFGQVRYQAFVPTKSLVHIRAGMEAITKSLQDHGHPQPILGFTDNVGADIRTFMECTPSLGKSVKLVDPAGLFSHLPQMELPPNVSPILCKTTYEIETACHGILELLDTEYNVTSTINLGFDMEWEYSTGIGGTGSKKTAIIQLALPYSVYLLRVYSLEKLPGPLETVLRSKRIIKIGRNIGADFSKLVQDFRGFVLPNKTGNQYEGIIELGSLAKQKQITSNANTSLSTLVAAVFQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQN7</accession>
    <name>A0A8H5CQN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQN7"/>
    <dbReference type="OrthoDB" id="3245714at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="274" mass="29574" checksum="ECC00D55CCF862DC" modified="2022-01-19" version="1">MPSMSFISFSSKQTSPSPALETTSPVHVESSAPPATSPDSENPSTTTSSDQSDASEPQSLSQTFYPSLAALKDQRAYEHERQRSKKAADLAKAKARKGQWSLLTYDSKRVSQILSRSSSTRSWTPEKSKRLRPEEATIAEALALDGIPGVTGLVHDNAHVRGGGDDASAKPEVKLADLISSESVRKPRARRGKDSDYELIPHVRSVIVLDDITTRDVSFDEPWEHIDHSDSEDSTSSSEPGAHKKKDSPKTYASILSVGSANANTNAIATQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQZ4</accession>
    <name>A0A8H5CQZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="2">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQZ4"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF32">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="4">
        <location>
            <begin position="78"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="501" mass="52568" checksum="DB57A3A49BCFB229" modified="2022-01-19" version="1">MADAQSQGSLMPKVFSCLYNRCRPRPCSPFLFSPPFRLLLPKPTHSFKISNGAPVSMLSASVLAFGLIASLLPAVKAHGQIKGVVANGVWNDGPNIYYDGDSVNSATVTRKMYQASSPAYLNYWDFSDNNKMACESADPAPSSISITAGSDLTIYWEGATSELLNKAGTGDTDGTNPWVHAMGSVTDYITSCNGACSSFTADDAGNAGWTKLATWGLDTSQSISDDLRETMAGKPEEYYPTADQGKGLWGIAKLVEDSSSWTVSIPKGLQSGEYLVRHELAAVHSPKSSGGGPQLYVACIQINIQDGGEDQLPQGTLAGSLYETNGSLANYDVYTDSTVFEDIGPAVWDVVSGLTGSSSSSTSSSSSNNDDSDSNSGSDPQPESSTTATVSTSKTPSTNTNVATQTNTRHLTSTSTSTGTSTKETIAATVAVVSTTPPSAPSSTFSSSSTSTSTSASSTGSATTGRTCKSRKRSPAGQDSKRSLAAMGRHRQTHMKRRLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRS3</accession>
    <name>A0A8H5CRS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRS3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="25220" checksum="4A98B2DB237AE02E" modified="2022-01-19" version="1">MGADVNAQGGYYGVALHPAAAGGHLEIVRYLVENRADAKAEEGYYGFALQAAAAEGHLEIVRCLVEKGADVNAGGRNFGFALQTAAAKGHLEIVRYLVEKGADVNAEGGHYGFALQTAAVYRHLEIVRYLVEKGADVNAEGGHYGFALQTAAVYRHLEIVRYLVEKGADVNAEGGRFGFALQAAAAIGHLEIVRYLVEEKGVDVNAQGGECGSALNAAYAYSHSEIAAYLETQVVTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS09</accession>
    <name>A0A8H5CS09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS09"/>
    <dbReference type="OrthoDB" id="2913000at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="440" mass="50395" checksum="040E051384053FEB" modified="2022-01-19" version="1">MGSAILIRLSDPFPCSAPFPRTYPATFFLPLSPSIMTSSSEAQLEALRPLGNAQNWTPELPSELERDIFELTAMTQRGSAVKLALVAQRTRIWMERLLYQTIILDSAEQVSRFLYTVDVRQPAFFADYVKKLYLTTWAELDTVLKILEVCTGITHLTSWAGPETPACKELLSTNLLPSSLLSALSLRSTPSYSSLQRMSVKTGDACGQHAPYHHLQRLACLGEHHQHVNFASWSQCSRYVYDDTCHRLFSSRLPSSFTLDTIPITQHTTPRSARNTNPVVFRVDWNGILRLPKLRHLSFGELYNPTPPWIEDSVIRRDLAASHRYLAYLLPLFLERCEHLETLVAITNDDESLEDIDEAFEAYERFNQLSRMSQPVTYIEAGSFRLRAGQEKGTEAKRDPRLVVIPDFHHPKNCLQYWSDICWRGEDFWDITERLARAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUX3</accession>
    <name>A0A8H5CUX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUX3"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="116" mass="12488" checksum="01126C4B2B37A231" modified="2022-01-19" version="1">MSQAAIIPTNSAPYAGLPEINQKLFDAKAKKGTYDSLVFVFVTAHTELVITGLSFEALAKELGKDEVWVASAFYGQAKFTNEELQKLSQVLGLDESSLVAVYLNLRGCGDLAQICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUY7</accession>
    <name>A0A8H5CUY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUY7"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="65"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5348345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="43832" checksum="6E9349CF0BBD6DE8" modified="2022-01-19" version="1">MSVRRTPSWVSDVPRIQTRLPDPEEYLRFLQIHCKPSPQSSVQMTTYDIPKTARAAVIKQFKQDVVLENSYPVPSPADLKPGECLVKISYAGVCHSDLHVKDNDWGFPSPLPLVGGHEGIGTVVAIGEHTVDSPVKLGDRVGLKWVARSCLKCCPMTVTHANGCSVNGTWADYVVGWTDYVQPIPESLDSAAATPILCAGITVYKAIKQSNANIGDWIAISGAGGGLGHLAVQYAVAMGLRVIAIDTGESKRKLCIDQLGAEKWVDFMESKDVVKDVTEAAGGLGPHAAVIAVGNAIPFNEALLYLRAAGTLVACLNIVGSSTGNRQEMTEALDIVAQGKVKCHFEVREWDEVNRHVRRKDHRKSGIEIGGSQTRDLIASDELTNRRAEIMDKTEDALGNESDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXJ8</accession>
    <name>A0A8H5CXJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXJ8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="819" mass="86077" checksum="1D738CF2BCD82C18" modified="2022-01-19" version="1">MQRPPSSRRYSEEDFGSGYVVPQNRQHHAQLPDTQAVGQPQPLFGNFHFQESPRPEQHGSWDVTFSANNESLNYESPRDYALPRLTTRERFEAVGTHVVEGDSSHFTDNDPSLELQTRSPAPEEGYRSFRLPTSPSHSLRNTMAGNSTFSSTSFTLSTPDVHNVSHSSLSSSNSFMQSTPVHRPPYRGYRLSTDPEGNQLELPPLDNLIPQQFDEDSRDDFSEYSPLEAGSSHSTTNPIDAKGKGRAHPSPPTGLDHGHDESIAQPHSLQGPYPSAPRPVHAQLPQRPIDVSVNGSFHSNSPSLDESSHIPIARSYSYSRPSLKRTRELEDAEHTEERENHPPFSATTTGADDVNAAMTAQGDVNAQDDEKEAEVRNDHSSPARKKPRYALGVSDNLPPSPNVQGSRGIPGGRGIPVGRGRNLRDRSRVVSGSASSGTARAAARATTISTAGNTTDANGKAPVRGTTVATRSRTTSTTQATTTSQPVPATTSGRSKMSIASLLASTPSTSQPSTTTTTAMTRSCSETTFVAPKTRLIVNAGRPASRAGQSTSTSTASTSTATSKTTRSAGTIKIPAAAARAKAKAGGANVGSSVPSASDASSSTSQPGSVESRFGRAGSILHGYWKRYYWHGHAAATRTGGTRATVSVAVERRVTRSATRTAANANATGVNATATTTTVTSSSTATNTGRSTATDRTTTGRGRATRTVVPQARTGANANSTHTAASSAPNGPSQASSIAAAPQAQPSTSTATATALPALQPNQTVWVLNGVVHLTKPPRFPQDTTAQAATRGGRGGRGGRGGSGSGRGRGATATRAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CY97</accession>
    <name>A0A8H5CY97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CY97"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="45"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5350241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="384" mass="41284" checksum="1E351963F86C3406" modified="2022-01-19" version="1">MSTFEGGFPAVYNPRQVLDHPDFRVLKPGEKTSSTANIAAFYNPAHEIHLVEKPVPKPGPGQVLVHVRATGICGSDVHFWKHGAIGPMIVTDECGSGHESAGEVIEVGEGVTQWKAGDRVAMENGVPCSQPSCDACRIGRYNGCPNVVFFSTPPFHGTLTRWHLHPAQWLHRLPDNVSFEEGSLCEPLAVALAGIERSGLRLGDPLLICGAGPIGLVSLLSARAAGAEPIVITDLFQSRLDFAKKLVPGVRTALISRTATPKEQAEVIKQVADTPLTVALECTGVESSIHTAVYSMDFGGKVFIIGVGKSEQTFPFMHLSANEIDVSFQYRYANQYPKAIRLISGGLIDVKPLVTHRFPLEDAVSAFHVAADPAQGAIKVQIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYJ7</accession>
    <name>A0A8H5CYJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_007779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYJ7"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5350265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="348" mass="38212" checksum="EC2BD49392226C3D" modified="2022-01-19" version="1">MNNSGRPPPAVFHTPGFAHYSLAWSPFHSSRIALASSANFGLVGNGRLHLVSVVPGPGGAPTINLDKYFESQDGLYDVAWSEVHENQVLTASGDGSIRLWDIMLNDLAIGVWKEHAREVFSVDWSNIQKDTFVSSSWDGSVKLWKADLPRSVTTIQAHHSCVYQALFSPHQPDLIATCSTDGTLKIFDLRVPTYVAGPNANNFTNPLSAAVLTVPASGTEVLTLDWNKYRPFTFATGSVDRMLKVWDCRMIKMGETGQVGGLCEATLPGHEYAVRKVQWSPHRADFVSSASYDMTCRVWSTVPNGAQPQLLYIHDAHTEFVVGCAWSLFEDGVLASCAWDGKLNVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZL5</accession>
    <name>A0A8H5CZL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZL5"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="251"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="45203" checksum="FE7516B57CBC6BC7" modified="2022-01-19" version="1">MPSDRPHPFAPHPKPSNSLGVLRVLSPRAGVRVSPICLGGGNIGDRWPGSSMTKEKSFEYLDAFFERGGNFIDTANHYQEEASEEYIGEWMESRGIRDQIVLATKYASCYKVMNPNVKQTANYTGGNVKSLHMSVRDSLKKLRTDYIDLLYIHWWDFDVTIEEVMDGLHNLVAAGKALYLGISDSPAWVVSQANQYAKMAGKTPFVVYQGKWGLTDRSFERDIIPMARANGTFSVSFSALNNQSLPRTLAGLALAPWNVLGAGRIRTDEEEERREKTGEKGRQLFGPEWKRTPEEVKISRALEKVAKEIGAKNITAVAIAYVMQKTPYVFPIIGGHRIEQLDQNLEALEITLTPEQIKFLESEAPPFDIGFPMGLYDPDGKNFIVNVGAYYQRVPDAQPLGPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0K2</accession>
    <name>A0A8H5D0K2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000070">
        <property type="protein sequence ID" value="KAF5351425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0K2"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="23606" checksum="6C1D961B46644146" modified="2022-01-19" version="1">MYYLEQYIRARKYAVAATYIEHSLLNRLIPPPQPALLTLPPKTENPRDSTINLNSCLGKNAAVDEEEEAIELHVGVNFAERTDLYLQIATSEAGTRQKSSQLLLYPRMTPKLTATLDVIKFVCKDLWAACWDKQVDNLQTNHRGMYVLQDNAFKTITRLSSWEGRANATRKAKLYVAMPAGLIKGALQRLDCWTHSREPEKYGIHTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3K3</accession>
    <name>A0A8H5D3K3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3K3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5351562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="265" mass="29774" checksum="B0F77835875FF915" modified="2022-01-19" version="1">MLFAAKSYWHECLFPSKRYLLSRSYGDRAFVILEGGLIIRMRVRNVTASPEWEGTTTDGTAAFKIDVTLIKDTILAQMLKPLPAADNSDTDPVFFVQLQAEFQLTLDETMASYLDFGEGVTLVSVRRENMPMVMTVHGSSGQTIDFNLGLDDNERSWVDILSSADRSKESVWSDSRGNRSSLVTGQWHRSANSGEAFTSEVMVGTGKTTDRYPFQFGSHWVSVHIMIDSVAVLPEDSGTQHLHRSADEFFNQSQRRIRYENSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3L5</accession>
    <name>A0A8H5D3L5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carnosine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3L5"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45017" checksum="5968909A654E396A" modified="2022-01-19" version="1">MSRRVIRVLLLLIVVGVGGWLLPRSGPLSINLNVPLPVTVRIDNPHALPVPNSGVDVEELKPTLRTLSSKQLSILTSITAFSRYLENALNIIAYREEQFGQLPSKQKPLAEAIGYSTHLEDARSCARENAKILGKVADFARDTYGFSPEEQTTEAHYEFVGDFLGHVMRDWSDEGRHERAVIFPPILKALEEGMSGIRGKKKILVPGFGLGRLAHEIANHEDCIVDACELDYGSIIAYNYLINQTIIPFEHTLYPYLTKWQYQQTGKGRYKSVRFPDVLPTSRVNLVEGDFLTEFPDSEQYDAIVTLFFIDVSENIIDFLSTIHRLLKPGGLWINLGPLKWGSFSHMQLSAEEVLDLAERLGFKVDHDSRQSIDAVYGHQVGSLLKFTYVTQFWTARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F154</accession>
    <name>A0A8H5F154_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000429">
        <property type="protein sequence ID" value="KAF5319859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F154"/>
    <dbReference type="OrthoDB" id="3269685at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5319859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22195" checksum="A142DCE53C7D8B97" modified="2022-01-19" version="1">MSSNIPPVAPIRFDTREGRSLLHSLAQKCLPYDPHDLSLDVTGHILEQKDVFLRTACGAGKTGIIALLAYILPDVCNRSALVPTFTPWYNKDPVILVLCPTDTLELDIEHKLKSMGVQATALNLEILKKAQNSEKQGAEREIWDAAKSSRVILLSLELLSGDRFHQEMDLDNPASSFQTCCSILIVDEVHMVWLWGPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8Y6</accession>
    <name>A0A8H5F8Y6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000368">
        <property type="protein sequence ID" value="KAF5328121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F8Y6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="19878" checksum="142AD319AE27ABF1" modified="2022-01-19" version="1">MAAAADPPWPFYTSTLQPSLWAFPPFQNGDALGPLLFHGPHVTTYIQYLPYPQTTSIQNHTRPIQPNSFHRNSFLEMEISPTSPQGARLMQKRLACEAKVQALEGKYKKEREKAVKEREQAAMAENKANVLEYQLGMLRYEAQLGSERVAELERKVEGLQRQLDDCRRALIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FB30</accession>
    <name>A0A8H5FB30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000333">
        <property type="protein sequence ID" value="KAF5330102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FB30"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5330102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="41571" checksum="CED0E564EDFD529C" modified="2022-01-19" version="1">MPCSSSITLKRPKARPSKQLTSLPPHFADKPHFNTLRNPTLSNTAAAAIAGAVKPETLHHPQLAVTEFTIWANDMGLHPNKALPAPEAVFCEFTASFLGCLAGGTVKVKVSALKTWHTTLGFKWNGADLLRCTLTGINRQSPPSSRCPERPPVTCDMMCTCHIAWATSSRCDLKCTSAAAKCSLLAQLRLGEIFPRHSNPCLFDLSKHPRVQDVVELPPPTPDSKHSPLSMFLPSTKTSVSRGDHTHIHDYHGSLNATKAIHLHVCSNDLSPTDPLMSFHDDSSKLKCITKSYFLSLCNNVWRKEGYPCFTGHLFCIGGTTLLLQDSVDPEYVKMCGRWKSSAFAWYWRDLHTCTTVHIDRVYARRRLQQRLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FD92</accession>
    <name>A0A8H5FD92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000313">
        <property type="protein sequence ID" value="KAF5332307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FD92"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="14426" checksum="679371981F289D73" modified="2022-01-19" version="1">MSQRGVSKDRGSDPDHGEHSSGSGKKEKGRRGRGRFAGRMRDSLPRALSALGLGGKRQKDDRPQPDTQGTGSTATSGQNTGTSIHTPKANVSILGQAKDFSMDNSQINVVGGAQYNTQNYFGQQGKHFNLPWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEW4</accession>
    <name>A0A8H5FEW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000256">
        <property type="protein sequence ID" value="KAF5334585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEW4"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="338"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="617" mass="70095" checksum="09E842948590ACCD" modified="2022-01-19" version="1">MCLYDWVQRCERLKVSTKKDVCDNAEQLPGVSFNDADSDTESNVSDSGSDAGFESDNELSTRKYPQGPKPVSKEKLARNVFPFVHGHPLADSHALKVVSDDKRLVPNFIGGTLPRADKGNREYYCTVMLTLFKPWRAGKDLKNKDQTWDDAFDNFQFTSQQEQILKNFQVRYECLDSRDDYNAQRRAMSEKIQDSYLPEYDDGIDSDLLDTLADPLNGESGPFERRRQEEMNKMKELLVDMGWTDTLHDQKTLIPPACQPQIDKSAHGWKLQINKMRQDILDKRHRSGADQKSNNKFKNPFPEQVEILDKTAFEQRTRQGHTQNLIDQIANEFQFQDNAEQERAFRIIANHAVSPCPQQLKMYIGGMGGTGKSTVLCALRKFFAERKESHRMLVVAPTENAAALLAGSTYHYMFGINSKPEGENHSTSIPQICSRLEGVNYIFLDEVSMLSCKDMYKISAKLALALSMPHLPFGGMNMIFAGDFGQLPPAIGGESVALYSHSIGHSPKSRADQESAIGQHLWHQVTTVVMLRKNMRQTETSEKDDNYRKALENMRYKSCKNFVPAFAHKSIVWNDSDPLPDTFESGETWQIIADDKIHQQKKSKQLRVSKGKVGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF72</accession>
    <name>A0A8H5FF72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000257">
        <property type="protein sequence ID" value="KAF5334574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF72"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="39848" checksum="81C99191DB0F376A" modified="2022-01-19" version="1">MSEDPASATAAVGRTQTPHDNAPSDNDTQSSALPNTTTKERGVKPEKFTGDRNQTKDWIAEFNNYLQLNDQVYPTEGKKISFFLTLFSGEEARRWAHNMMIKVFGEDDFSDSDEGYTSTNDDSSASKPKMRKKPWTLHEVKREFLWDFKPSARETQAQTKIEHIRMEGTLADIDKYNSQFKRYADDTGYNDKALMKYYRKGLPRGLVDRISYLSSQPKDLATLQKAAVKQHMIWLERQEEKTSWSKPRREEGQPGRRSQGAGGGRMRSMEVNAFQDNVPAETASSPLVTVAQASSSRNTIKDISDMVNRVKGLEGEEKEQATVYLKDIMSKLDFVELAHSVAAINVFYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHU5</accession>
    <name>A0A8H5FHU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000207">
        <property type="protein sequence ID" value="KAF5337765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHU5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="11662" checksum="7D5D0AEFB753E3AD" modified="2022-01-19" version="1">MRQQPSQSVPQLMEWRPHSNFMKSQRPEGGPTLTATVFDEVSGILVASAAGFELEFTELKKEARGAGSGTRTVHNNGQYGCSGEEGGEGSGRCSFTGHLEDWRATTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI28</accession>
    <name>A0A8H5FI28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000213">
        <property type="protein sequence ID" value="KAF5337604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI28"/>
    <dbReference type="OrthoDB" id="3057283at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61106" checksum="49C5708D69722AA2" modified="2022-01-19" version="1">MHRCCCTYSCTEKATLTPESELFQRVREDGVLDDSLLPGIVSHLSDAQDDLREYEEQAAHLRARLQILDAKITALKRNVDLTRSLLSPTRRIPNEILARIFEFCDVGLIPADRRYRDPAILSVSTRWRTVALTNPSIWNCITLEVFQMAYRQNLPALERILERSKSTLLSVTIFLKQDGSGIVGPRYTTKVIEALIQHSSRWSHIAIQYNGSTEASSCLHPLATAVLDARNLKEVAISSLVPPSWFSKMLTSPKLDTLSVAALSQEGIANIKSSASLRKLRFSICGAYNPATLKNLEVMDGLGTLKELELDLRYPMLKGQSDNPAPLSITSPLTTLSVELTKGDPEADQYNLLTRTISCLTLPSVQKLSICANVRTIPKGFWPIQQFHDFFQRSECSITSLKLCGLNLTDQALIALLSCMPALTDLCLAEWKTYGAVPTIGLTTEAIQALHSTDYALSSPSFNVSQPLVPKLSRLRLTVNQTFDEEILANVVDSRRNLWTDEVEASVRVAELKSMGFKLSGRKINEEARKKLMGLQQGGLRLTIQDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKS7</accession>
    <name>A0A8H5FKS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKS7"/>
    <dbReference type="OrthoDB" id="3052647at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="41797" checksum="3FF1683E508A793E" modified="2022-01-19" version="1">MPPKSTPSNFLIVDDTDPRLNYTGKWEQTSGSAIQDDGSTLNDLTYTWLGKIWNDTVHETKSNGSMVTFSFNGTAYAVFGSFLFTGLKAPRGRIDCLLDGNPVPDDFTDMAEDSGSLLGNNILICGNPSLNGTGEHELTVKIKNLTHSNFFLDYILYAEPAVDGGLDENGDETSPDQNGNSSEVMMIGSPFGSLLDDASEHHLTFSSGWSFDDEIGSVFTRTPGTFVSLAFNGTGVQLYGDLGEKSNLSNIAMYQLDDQDLKPFSLLPPNDGSDMFFLQQLLNASGLSPVDEHTLVVTHNGTKTGMALSLDFFIVEQASTSSFITTPPSSTPSSESSGSRPSTGAIVGGTIGGVILLILLTSVAVLYIRRRRRQEQSTEWTQNKSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLX3</accession>
    <name>A0A8H5FLX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="91"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="788"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5341457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1341" mass="149452" checksum="C645DA3D3F14B3A2" modified="2022-01-19" version="1">MAAKVEELPEELELSYSGSSENTTLGKDNLSQNETEAQDDAFDLESLLGLAVEKLDQSDLPLRSLGVSFENLRVQGLASEASYQTTFGDILNPLSIAEAVNNARHPLKRDILTGFEGVVKSGEMLLVLGRPGSGCSTFLKTLANQRAEYHSVEGEVHYDAFTPEEVRKQYRGDVIYSPEVNQTISFAARLRAPASNGRLGLSRNAYADLLTTHLLRVFGLTHAKNTLVGDAAIRGVSGGEKKRVSICETLAARARIVSWDKTYADSDQNCSSTRGLDASTALEYARALRAATDLGKMTTIASLYQAGENLYKYFDKVCVIYEGKLAYFGPASSARQYFIDMGYEPANRQTTADFLVAVTDPTGRIPRSPSSTIPIKAHTYPVPKTSAEFASYFQTSHLAELNRIEIQAYKQEFVNSDPARIREAYQRSVKGEHVRMSRKRSAYLVSLGLQAREVMRRRLQMLKGNWVATFLNVFSYVFQAIIVGTMYLKTEQTTAAYFSRGGVLFYTLLFSALVDMAEIPSLFGQRPIVLRQSQWGFYHPFMEQLALFLVDLLISAVTITVFGVIVYELVQLQQSAGQALALAAACRAESVAQTLAGVVILASAMYTGYLIPRPSMVGGLGWISYINPFRYAFESIMINEFRTLNGTCATLLPQGPGYENISLDNQVCTTIGSIPGQPAVDGNRFIEMNFGFVSSTERIWRNFGIICAFIVGFVGACLIFTEINTTLSTNAADSVVLYRRESLLGHKRKGPSKRQSDEEIGSNKDVTFETVPVDNEKHAKASFQELDLAMTDVFSWQNVNYTRRLLNSISGYVKPGKMTALMGESGAGKTTLLNVLAQRVSVGIVTGYRFVNGQDLPKDFQAQTGYCQQTDTHLPDQTVREALLFSAQLRQPISVPLKEKEAYVDQCLKMCGLQQYRNATVGSLNIENRKRTTIAVELAAKPKLLLFLDEPTSGLDSQSAWAIIAFLRELANNGQAILCTIHQPSAELFHVFDRLLLLRKGGETVYFGDLGHNATTLINYFERNGSRRCEVDENPAEFMLDVAGAGATAKSVIDWYSVWTSAPESAALQTEIECIHKEGREKPAVQAALHTEFATPWLHQVSQLIKRDMLSHWRNATYIMSKFVLLVLSGIFIGFSFYKSPFTQQGTQNKLFSIYIATVISVPLANQLQVIFIHMRNIYEIRERPSRMYSWTALVTSQFLVELPWNIFGTSLFFLCWYWTVGYSSSRAGYSYLMLCVLFPIYYTSIGQAVAAMSPDAEIAAVLFSLIFSFVITFNGGMQPFSQLGWWKWMYRLSPYTYLIEGLLGQALGRDNLRCSDVELVRLDPPFGTKLFFVSQHLHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMZ9</accession>
    <name>A0A8H5FMZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMZ9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034412101" evidence="3">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5342716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="20526" checksum="E5C39EF45422A8E4" modified="2022-01-19" version="1">MAFVKSFVCLLVLSVFQTHYGLASPTNGAFRDLHIRDVPGSALTSSEVPTQCAGADLCGYDGPACLNDTSASPEDMGKCICTQDLANHLTNCFNCAVSNSNGAFTASDGQSVFDSYISSCQALGISINNVTIGGSSTGTGSSSTNSSSTGTGSSSTNSNTSGSKGGSGSSSGSASSQSTGNGAVQPIAVSYLGVLGFILCLSAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNT7</accession>
    <name>A0A8H5FNT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000136">
        <property type="protein sequence ID" value="KAF5343649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNT7"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="22576" checksum="1828290A0B5A90E1" modified="2022-01-19" version="1">MISPSECKLDIIVVGGSIAGLSAAYFLQQAGHHVTVIERHDEEYFRAQPFSGLRIPATVARLCGELPSLLDLLEHRGVHHPGSVLRQVEDYQLVGQMVYGERIISDLGANGYRIEYSEFWEYLYQLCLGNQVQFLFHLEATDVITAGSLHQPAKVITSSERHIAGDLVIAADGHNSKFCDLIEIIQPWKPSAVIWNGKARDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPQ1</accession>
    <name>A0A8H5FPQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPQ1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034124152" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="79" mass="8170" checksum="8CE387C88AE59909" modified="2022-01-19" version="1">MQLKLNKTLIAVTVMLITTIRQSAAQECSSSDDCPGTDVCCIIGSGFCIRFDQCVNVEDNGFGQCTIGGPGGVAHGLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPR5</accession>
    <name>A0A8H5FPR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPR5"/>
    <dbReference type="OrthoDB" id="3022280at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034323372" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="63" mass="7035" checksum="611E26347E5BF792" modified="2022-01-19" version="1">MRAANPRMEFLIMIYLILAARQANEEVMISFDNPDAFVGFSMWEAGGDHNDLLLDAIRGTAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ58</accession>
    <name>A0A8H5FQ58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ58"/>
    <dbReference type="OrthoDB" id="3252971at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="412" mass="45279" checksum="E83BEE125EDBEC77" modified="2022-01-19" version="1">MLVCKSTALANEFAFYSFCAPHWSGDARATFSVCDAFLKLLTKEVQVRSFDHSLLVYSRHRAQALNKANLPQTSLPWGEEVIRLTPSSTVLMPDAGKEVALNPDPSTKSLTGDSLLEKIILSPAETQAISLACKKTRCSLTVLLNSVLLLADVEKTLRTLHTESLIQNSPSLSTLIEENWLKSEVFCIPANPVDMRAFIWPRDQVAHGQCTSGGIVNLMVPSYHSMNAIRKCLSFKDGKVHRTWYDNPTAFWDELLPDTGRLLKAVAKQPPSAYHLSASLAEQMAPVVGSTGSESLYVKPIGIIPSSIGSMERLGLYSDFSPLAQKDKIGTNAEPPFLMPEMSVGVRSHNTPAIVISIWEYNGSMVVNVQASKRHQTAESWKIFGQAVRDGIKQIVEGVPSRGRKEDTRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQA9</accession>
    <name>A0A8H5FQA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQA9"/>
    <dbReference type="OrthoDB" id="10005335at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="40954" checksum="3A3B45AEE03D96D6" modified="2022-01-19" version="1">MSTTGDQFVRYPQTPSFVGMLDSITTLTEYEATVPDLSSLLAPKGGTFLGSVKLHGTNLTIVFRRTADPGYPIVQIQSRNRILSVKSDNGGAFVFLNGKPLHLLVEKILGLQGGDPSYKEIFIAGEWAGQRIQSGVALTKLPVFLAIFNICIDGKWVEDMRKYRNVGLPEHRIFNVFDIGPTWEIRIRDFKEKEEVDRVVKITNELTNEVGKECPFAVNVSKYLLPQGPVARGTGEGIVWTMVDAPEGNLWNFKTKIDTFSTVKSSATKAPKDAGIVQKAQAFVDYACPLDGRRLMQGLEYLKEVTGIQRVDLKYTGQFIKWVVNDTMTEEGRELERFEADPKEVKKLLATRAGSWLREQTGRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQG8</accession>
    <name>A0A8H5FQG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQG8"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30210" checksum="B6C021D72ACCE50E" modified="2022-01-19" version="1">MPTIAVVAAGAMGSAVARRLVQSGCTVLTNLDGRSEATRHRAQEAGMENASFSRIAAEADYLLSILPPRDAVSFAEKFLRESASARREKESPLVFADCNAVNPVTAKRIASLFSGSPMKVVDAGIIGGPPKDGYNPTFYASADEEDVLEGFGRLARYGLKISLLKHGEGIGDASALKMSYAGITKGTTALFTIMILAAQASSPATAEALKTELQASQPEVFARIQRSVPSMIGKAWRWVNEMEEIAGFIGAEGEAYNGIAKIYERIAKNSGEEVDILEKFVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTP5</accession>
    <name>A0A8H5FTP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTP5"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="631"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="844" mass="93306" checksum="E685E9A556F1717F" modified="2022-01-19" version="1">MAAPSRTQTIVRANTMYHTMLGRIRSLRVAKPGFRENESPYVRTRAQLLALEIVLSSGIGSRHDGGTLSNLICANITGQALCTEKGFLPCPRNRDPYFVLSPSCAFSGQTNKIPSIDLLNLASSNEGGNCDIRSKDFKLCFLGCTDIRDLVKTVNNLPKDYRGKCTILINNSSPIHINQVLVVLYILLCSNGASLEECAELATHLMYSAFLTRPGAAYLQKAIDKIYETEGDISFRASFPTRGSGNIHTLQTLMGVKQPLEMFQTSFSFVKGLKRMRNFLSIPEVMDQHDHLFSKLIPTHRAAFKRFHETGVLAPFSLSTDHFTHPNRLLFSPNGEWLQPDYFNPFRGWDVAASQATGTLKRGVDSGDIFGCLFFHVKAQFREFARRFQYLSIDIYITQFNPKILSSGLLAGVLPAFPSDGCFDRIHVGDLIDSVGIQDCLADWTPLLNSSNEHAALLMHSKIWCATRPDALALSNPIVAKGVLIEKCNQNPDLVRRAKFQKMCSQGLRSPTLLKILESLDVFADHSLWFHEYLRDEEAESTAASLGLQLRERNQIHPKRFGVPLDAPWDQLPDLGRSEFYYTSLSGVDFRTRFIEFGLSGHVTAMWTLGRRLLSRAANDERVQAQFRSLLRECAQPVTVLTSFLPSSTHYHGATLSSFTSIAMDPFPLVAFSLRIPSRMAASLAKVHSNNQNGIDPDVGSHMVVNILSAAQANTAVIFSRPDLHPDPFSEVKYSLNSEGIPILDGSLGAISCKLVAPPIPLHDLDVLKGAFGNSDTKAQVANPAASLQGGAVSELFLARVTNVEKLAIEEVEDGHSETIPLLYRRRGYTGCGPTISTIQKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV46</accession>
    <name>A0A8H5FV46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV46"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034584665" evidence="2">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="47750" checksum="56F6FE3DF34376B7" modified="2022-01-19" version="1">MKSYVVLASLLSSAYGHGLIAAVTGANGVTTKGFGVSTNIPRNGTAEQPFQLDTPVLKNMVDDPCGATLQGGSINIQDGFTQALKEGSGSLPSIAADGSVTMTIHQVNADGGGPYVAEVNTDGTGQTWQTITVTQQVPGANGLLRGGPVDSQLVAVVPQGTKCTGGDSGNACLVRINNGGAGLEDSFANGAGPFGGCVAVINNDGSTGAAGNSTKGAAASNNNANANAAGAGRGRFRGNQRRTVSHRTDELRALMAKRQELDEEIELKRRELVERQLLTVDLIDELKTTTGTAIDIPIDAFAGQIDSAANGGNSSTAPDAILTKQQAVDLKKAVQNAIANVLIAMSQAQNISVDATGFTVANKLTAEKIAQANDAAAKALLDGTTTSINAGNAGVGEPNTALINSLLGGVSTVSVPAATATAANPAATAATNRGGNGNARNGGGRGRFRNAVFNKRQFRSRVARHLFDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWW7</accession>
    <name>A0A8H5FWW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWW7"/>
    <dbReference type="OrthoDB" id="3249923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="790" mass="88482" checksum="D10AA0C623FC0EC4" modified="2022-01-19" version="1">MSEFYRGESSSSGRWNLPGPSQYPQSTSTPRAFRTSTHRHAPLASTSGSNRSFQSSNRRPSNVTPQRFNMIQPPSSGDRRASIMTPATSTSNRNPAVLASKTSSLWSPWHDADLRHTAESNRTRKDIHSKRPETIRKWQSHARKRASNVEDDESDVEMESAYSDSGSDAQGEDERPPSVAKFINYVAPNVGHPAVRKITAAKSARKRVEVISDDDEEEEDEENSSSSEDDDDQGDVPSQTESEENDDGDDSDSSDSVEFIEDEPCRRRRPEQMDISPTSSRGGSPFVTPVTSIMSPALLRAIKTFLPPFSRQNLPMKLSHLRKAFERKCIKQGVMTAKLVDEVVKLSVLYRLAETTSGQSEDDSDADQNETGNSPGSPTRKLNSYGVMFRFWKCPLCSFHGVFNTRQMLKSHLEWDHEDAKVLWDQGTEDDDFTWRIILTFDEPTNERRPLNDLAGRPFIYAHPIYVDSRENTPVPTLGTPTPAPGLKPDIELEELKFRMTSPFMEPSTTRSPSTTPALTDSRTSLEEPRSPSPDFLTGSVPPMSMRSRSTTSFASTTTTDTTTTTETGTTTSWDSAPALQTPPRITRPLPVPSSTTRAGAGAGAILLPFPDLPPPPPKGDSLGPAARHPYLPTRTPQFMVEKYRWKTKYLSHSSRPGGETLYDLLGVLPLEPYGLMAWQVLDTEDEIFESDDLRDECKVIAALWARWMVLNRRKFIANFYFGTMAFIEEYAWMIYWAAGWGALRYQLIILMANRFLNCSQVANLLKHYEGRVEMDSWYKDSVPGAQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXE6</accession>
    <name>A0A8H5FXE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXE6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="33886" checksum="2E0AFD5A120560FD" modified="2022-01-19" version="1">MSSYYELTSKDGGKNRKADGFNAFDAGDVLYIPGLIPVSKESLEEAVDASWICPRRTVPIIAFGTFAVPTQEDHHYFKYAVPSSAEAKEWVCEADVWDDNAMSIGDRDQEFKNSVGPERVLVAASWIPFGGRGRREGGRDRGTRTRTSGGGAAAAAAAGVGVYKDGYGNGAIGRRRRRSSVLWEWDGTGTTGADAEAGSWTLGLETGLGTGIGSGSGMGTGSEYDYECVLVGDTAAGEFNLKVDVRFLFTMRICYITPRSFDPISLYTQIMHCSGRDHVKLHRVGGCHGLAWVTIALPVPMQQLQTVTVLAHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3G8</accession>
    <name>A0A8H5G3G8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3G8"/>
    <dbReference type="OrthoDB" id="5582182at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="199"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="432" mass="47897" checksum="58695715FE373717" modified="2022-01-19" version="1">MSQNWTYYNTPAPSFDPHTGADTTAPAVDPNTPANISFAEYVAIGEAIDAIKDLQDWCTATTTTLDNIQTRLTNQDTILHNIQDAQTNTATSIRNIKVIVTNLTQQPSTQSLTTGDQLGSTSTSTSDPTANTAFTTSSSTTTTSSSQKPPTFELLDKFKGKASEVEYFIREVKDAIELLGVSLPLDRQKCIWMARLLGDGSPKQWYFSIMTSEPDILNSFDEFVERFKDHFGDSNLEYNAEMKLKKLKQTGSASAYASRFSELVVHVDWSESTKINQFYTNLKTTTKDYISQTKRENRPKKFLDYKKWVIDIDNCVHECEEEHKEESPSKSSSSPSKPTKNSNSHTTPPSNNSTANSSLPPGEPMQVDATKTGKPHPKLSDEEKKRRKDLGLCGYCGKCGKDIDNCPNRSPYVVKRMEAAKAARASSQSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3L3</accession>
    <name>A0A8H5G3L3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3L3"/>
    <dbReference type="OrthoDB" id="3263183at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="303" mass="34718" checksum="E58F4DFF9D6519C8" modified="2022-01-19" version="1">MTDVLLDPSYKLEFSLPLVSFCKDVRRKEDRFIKYRVTEIVHYKERTPIAHEYLHINVFDGEGSTIKLLADRRPSGRKPVARDTNGSSGMFSGESSGFSIPGMFKKSDDSISRVLPKSSKREGGGGKEPNPPFKISTYRFPSKPAFSLIEVCGIFEEISAMAPNYTLLWNQCYWFCSTFFILVDKQLGDRVKKIQGKDYALRGKFAGELIGVTDSRKVKEQIEQYERELLEGVEQEQERRENKAKAIFMAAVKERKSKKAEFEEETRATISSLFLTAEERAKRDEQEVRSLWTKMLTKKSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G6D4</accession>
    <name>A0A8H5G6D4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein 1 light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G6D4"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5359011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58223" checksum="49B6A31C4F0D5F70" modified="2022-01-19" version="1">MDARSSSPEPPPQDLWSSILDSVSTTRTIPSKQILILGQPSTGKSTLTSAFLQKPASDDSKDENKIDFAIGYDFADVRDDADEDTIARLSVYTVPSADHSYTALLPNFLPPRTALPHTLVVVVLDWTRPWTFVEELETWLQWIETWSQGDGSRELEIAREENRERWQSHLQHYVEPSTDPIPATSTLSNTVLPLGPGILTHNSAGIPIIVACTKADLIDEGHDLVAGVSGMGGMVKGTGGEWEERTDGVMQILRTISLKYGAALFYTTPQPETLQVLRQYAFNSLFVPPAPSPGVPGTDAPAPVRNPFPFQHKPNTLDRDRVVVPAGWDSWGKISVLREFDPKAWGEAWERDLEGDSDGSSAKALFAALVPDQGAKPPPLPPFNNPTPEQAFLAKNYDENSKKADRDPRGAFRDPGELEGATAGIVGPLGPSGFSLPNVATALSKMENEMINTLTSAAPERRVPGRPANRPAGLQPPSASPPGRGPASPNGTPSPTGGQTQHEVLQNFFQSLLTKDRPSGAGASRAPKTNGTKDAAEDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Q3</accession>
    <name>A0A8H5G7Q3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Q3"/>
    <dbReference type="OrthoDB" id="3225557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5359939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="399" mass="45337" checksum="6BEB707D56DD4C5C" modified="2022-01-19" version="1">MIGSQDNRESIVRVFQVIFRYLEAWFPTGPSASKSLTDVTPLAGAKRLIASDWLAIVEMILYYNEVAAHFCDDLTDLDNFIRISKPPTKEIVAFLVRVDNKSRKAGIAARKVLQALDRMERQIIKMQSGLEQQASNMKSPTLFTAPRLNALTSPSSVIHRPSAESHSRMRPREGSTFSDGDILQTLSTRIKILIPHLQFSWSQVRGYLSQIKGFLRKDDLSSIPPLIQKILDMVRSQVSFSTLAFEIRKLQVFYPVVSQKPTELLWVHKHLVACAHQISKIWRSNEPYYHPAVIDTLKAAFWTDSQNHTCLGKKYINYFGSTIEDDDAKEVPMAMLGLVGVMFALFGHKARDLQADQATKREGSEELSSPKPEPSDHEQENNSAQTLLTTMRTWKRTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G802</accession>
    <name>A0A8H5G802_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G802"/>
    <dbReference type="OrthoDB" id="4334193at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034097350" evidence="1">
        <location>
            <begin position="26"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="515" mass="55877" checksum="701B9E995663356A" modified="2022-01-19" version="1">MHSRSNWSLLCLAPLLAIWLTPVAAWVAPTLNQRQQQLLHDRLYQTNLRGPRWTGNDNQNTLTDLVARSMRIAGLDVEFLNYTVHKWDARWWSLSLNLKNGTSLGLPTTGYWPWSGDSGLEGRTAPLIDAGTYALDATMTGSDNSTLDFTGLPETGGIVFFDNPSPTRNYLLPGYKLLGTSRDIPADDIPELGNLSNPHWQSAKTLNFTTLRTMGVEAVIASWVNTSDENGANQFLPNDGAPGDGNLYDVPAVYVGNSTGETIRELIKEGLVDNATVVLDAPSIEATTSTVHGHLTGTSGTNDSIIIYTHSDGPSIIEENGPILLLAMAEVFAQHRPTISIDFVITTGHMSGHHLNESAWMDERPEIMANAKAAIVCEHFGALEWKDDFSTGSPVYKPTGDLEPMWTMANGSSGSLLHELYIESFSGTEDKLRMALLAPQVVNGKSSMWYGAGGSSVLGASSIPTIGIIPQPDYLWAALVDGGWSKLDIPTAVEQINVILRLVTKLDEAYANGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDM4</accession>
    <name>A0A8H5GDM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDM4"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034338649" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="251" mass="26615" checksum="50A0D7D55E198210" modified="2022-01-19" version="1">MLRLAIALSLVLPALCQTAPTSFVLVGDSTTANGTTPNSGGWGNGFCGSTVTSTPSSLAPGTPCINTAHNGATTGSFVADGFWDISLAAIRGEVAKGRRTLVTIQFGHNDMKIAPPESMGQNLTMMVQQIRALKAEPVLVTSLTRRDFNNDGTINDSLGPWADQTILISQQQNTHLLDLHAASITYVEAIGPDPAHRLNRTPDDNTHLNNNGTIVFGRMVADLMNASFPNQLPIIANPALTFNITHGIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHX3</accession>
    <name>A0A8H5GHX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin Tsp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHX3"/>
    <dbReference type="OrthoDB" id="2156690at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="66432" checksum="4E0D19433E3309FC" modified="2022-01-19" version="1">MTGTNTNANANASVTNPNPNSTSQTHGHSSSNPISQPTSPASLTFPTSPLSSSALSTISALVPDPESGTSSARPRPPKNNNMASASGSRVSLAINYIPQKFPHPLGIAGAVAGVDRRDERRSSRATITTQASAAASSRVKRTSTATAASASAYTNMNTNLNTPEFSPPQLRMPMATSGTGSGSGLGGGSGFGLALGQGQRVSWFDQSQTHSRSHSQSQNPELGGDEVTEVAVEESTPRPQPRHAPAQGSGYVNPAARMSMGKRLSMAVSASFGGLRFRSTAAKNESGHGSKMIGLKRGGGVEAFGTNPRVNYEKRIADVGDEDYDGVMHMGVMDEAGPSGSSPTLGDDVDVRDGEVDVRGIRKTASKRKMKWNRFKVVLFCTNTLLILWSILGFIFLLLVVFDLFPSSLQDTGTLDYGHGHASILLIGNHTELAFSFLAVSFGLFTSLIGYTGILLNNRSFLAVYTFLTWVTFAFLVVPGYVTYKKREFNLEGKVDGEWSHFGRDGSVGFERLDGLDARRRIQNALGCCGWFSPYVEATITQTCYSRSTLPGCKLPYMDFQRGVLKRFYMSSFLLVPVQIVVMVVGLLCSNHVTWRFGKGMMPEAYRMDGGLGGCWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIC1</accession>
    <name>A0A8H5GIC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIC1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="429" mass="45735" checksum="494049BE53108583" modified="2022-01-19" version="1">MTSSTAANKSHEIVIIGGGIIGCSTAYYLSRHPSFSSQSTSSPITIKLIEASKQGPAQGASGKAGGLIAKWAYPKELVNISFAEHVKLAEEHNGKDRWGWRFVDCGSWEGKGVLSQESGTGVGKEGNRKSLEKTLGLNGDHEELEKPLDLAKRRRKGLPDDLLWVDEESTYSYSPMAPKGHTAQVHPYLFTTSMMSLAQEKGVEFISGRVTNVLQDHTSGKITGVTYLESNPDSGAPKEVTISATDVIIAAGAWCPSIDIVSSLPISATRAHSVTVRPQPSVTISPYVLFTEISLSGANVSPEIYARPDNEVYACGPGDDSALPDNVDDVLVDQKACESIYKHISSISPQLSNGTVEKRQACFLPIVSTGGGPIVGAASHIAKGLYIATGHTCWGICNAPGTAKIISELVFDGKIRSGNLKNLHPSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIH4</accession>
    <name>A0A8H5GIH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_003218</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIH4"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5365638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="235" mass="25597" checksum="B79C21A7C32980C2" modified="2022-01-19" version="1">MSQRKSTKSQVKKEQDALQQYQDTDGHFSLVRNFRLADLVTIMNGVCGSFSIFSSARYLLTNDMDYLWSALMFPLAGLMFDFFDGKVARWRKSSSLLGQELDSLADLISFGVAPALLAFTVGLRTYLDTVALTAFICCGLARLARFNATVALVPKDAAGKAKFFEGLPIPSSLALVGMLSVWTKMGWVEGQAGIPLGTTTLWGAKNGSGEIHIVSFIFGCWAAAMVSKTLRVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIZ9</accession>
    <name>A0A8H5GIZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIZ9"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5366004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62292" checksum="15DE0966665EFDEF" modified="2022-01-19" version="1">MLNTPYLLAIPVLLVIYSLCGYILRRPRQTLSYPPGPKGLPIIGSFFDMLTPRTEHDAQWAIYRDMGNMYRSDVLHIDILGDHTVVLNSAKAAEELLERRSGIYSSRPTMHMANESGWGFNFGTMPYTSWWRLHRRTFHQYFRSDAIAAYHPCIRQATSRLLRSLSSIQSTTMVTQYDDLHTIVRQHAASIILYITYGISEQEDIDAFVELVNNAAESINATINRGSFMVDYFPLLRYVPAWFPGAHFKRKALHWSQFTSELVNKPWKQLRASISSGTALSCFGTKCLQKLDLTFNAADATEDTSDLGVSKTDSDTRIEEVIRNCAGTAYIAGSDTSVSLVIISVLVLSHHPEIQAKAQEELDRVLGSATQLPDFSDRGNLPYVEAVFKELMRMYPSVPLGVTHYSVADDVYEGYFIPKGTTVVGNAWAILHDENLYPDPLTFNPDRFLRTEPQRGAPPAKHSLNPDPELYAFGFGRRSCPGKHLALDTSWLVLACLLATCNITRISSDSTEPDSKEIDPIAHFTDGAVLHPKPFKCCITPRSAGAFELMKSGYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ66</accession>
    <name>A0A8H5GJ66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ66"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5365759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="339" mass="36407" checksum="CB9C2FB5763E32EC" modified="2022-01-19" version="1">MPLVASRLDKSSIALSFMSVLPKSTPLVAPGHTRPITHLSFSPAQDDGTFLLISSCKDGNPMLREWTGDWIGTFLGHKGAVWSTKLSPDASRAASGSADFTAKIWDTYSGSALHSFPHNHIVRSVAISPTSSHLLTGGQEKKVRIFDLGRPDAEPDFLVGEAGGLSHEGVVKSVVWVGEHTGVTAGEDGLIKWWDLRTKKLTTSITFPKPITSMELSPQTGRLVVTTGNTVAFIHALPTNAGAPSHTLTLPYSPSSASIHPILQDRFVTGNLGDEWVRVHGMDGEEREVLKGHHGPVHCVEFSPDGEMYASGSEDGTIRLWQTTPGKSYGLWQGQTNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJP3</accession>
    <name>A0A8H5GJP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJP3"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="333"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="873" mass="97178" checksum="D3C34B226229C6AA" modified="2022-01-19" version="1">MPSKRSSTSSSSRNRPQGNLLYDEPTGGFKKRRLARACDACRQFDVGYSSISKIDAENDYSSITVQSLVEDILSSTIPYPVPEEKDAVRRLVVNLATYARKLETRIQSLAQSLAKMNPEFPDTLTSDEPVDDGVEWLSDFLSSVSVSDTDRKGPFLGETSTLSLVKLAWNAENRYRPEDVDPCNDEGLSTHEELANMAAECLIMSRFPSGNSLEPGRQLNFPPYETILRLTDAYFAHVSVILPFLHFPSFKRRLSDSLHLRDQDFGALVLSVCACGALVNSDLQAADEIPKEEIEAWYDQFDPASMNFLRPMSLYQLQTILNSIILIPLWLPNWMILCNTIRHVQGIGIHRKQWYDQQQISPVDKELWKRAFWILVACDNQMSDYFGRTATLVPEEYDLDLPLDCDDEYWPGEHPDSGRDFQQPENKPSIIAYWIAYLELITIYRYYQRTIHAARRPQFIMGDDPNWRSKVVSQLDSAMNKWVEKMPAHLRWDPKTRNVDIALDYQASAERHRILEVQKASLYLTYYCLQIQMHFPLVAKAPGASATLTNAINGGSDSHLIVCVNAARSCVHLLDMYSEKYKVPPLMHIFIRILRLALILVFNASSRKLNGLDSNSGSAIARDCLRNDWTGHLCSWTMNPIASEIIQNLIDKCDGPKTGDECVTAGERTSTSTDLTRSPKSTSDVHVPSAVSHSLHPTINDQTTVPAMDHDLTMASNVFDGMAGLDAFPNSSSDPSSSSSLPWNFSGTAFNGDIDSIFHPMPFFSTSTQASVPAPGYAYLGHNDHDSQEGHSAPLMDQATIIGGGGGGGFLPMNWGFSGSLPHGDSLSQATAAFAESETGTGTAFSVNMNSDWIGNLFGELDDTLGSWNETAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJS3</accession>
    <name>A0A8H5GJS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJS3"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034898245" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="557"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="442"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="64806" checksum="A0A9CE32152F99F6" modified="2022-01-19" version="1">MAPSLLSTVVVLCSAALSVLADSPISPGFSYGSTKVRGVNLGGWLVLEPWMTPSMFDSLNDSRIIDEWTFAQYQSKAVATLALTNHWNTWITEQDFIDMQKAGLNHVRIPIGYWAFDVSGGEPFIQGQIPYLQNAVAWAKKYGLKVIVDLHGAPGSQNGFDNSGQSMSYPQWQTKQSNINRTKAVLATIAKMFKDQTDVVTSIQPLNEPAGYYGDAILSPLKQYYYDSYGNIRFPYGNNKQGNALTLLHDAFQGVAYWNSFMPAPQWQGVAIDTHIYQIFSDAEIARTNQQHIDSACSQGTTLSAASHWAIVGEWTPAMTDCASWKGVSRYDGTYPGSPVIGSCKGKSGKASTFSPEYKTFLRQSWEAQTLSYEKAAGWIQWSWKLENSDDWSYQAGLQNGWIPWNPDDRKFPQICSPNALLNIYPSVTLSLSLGTSSTATANSTTATSTSASVTSTSASTTTSTRASSTTITASATNTASTRASTTTTTSAASTTSTRASTTTTTSTTSTTSTRASTTTTTSATTARTTSTTASTSTTTSKTSTSASSKPTSGTCPNYTVVAGDYCWLIANNHGTTVAKLQAANPNVSCNPLRIGQVLNIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMH8</accession>
    <name>A0A8H5GMH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMH8"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="336"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="54443" checksum="89029D8D6EB1A3E0" modified="2022-01-19" version="1">MSGSEPNCDSTRQPIKATMELPRLPSIVMSHPFPGQQYQESLTTPSTPQYPTWETLDNMTQPVEQHEHEDTQQQQHHQQAHGIDFPDILASVPHQIEIPEQFLTTSPLHHNTIQLPPAQQPRSDGAPSPADFTSEHYGDNATSMRASTSTGPVGPTARSSGRQPLRQSPANPTANPTRMHPYRRPQSAASITGPSTSSSSTHPRAVVTRSPQVTTPIISIPASAMSTPPSSADPRVLNFSSAPSGKTPYTSPSSMNPPPLPMTPSEAVMPHYLPPQHPPPQHPVPQYPQHPPTQQSRPQYQYPPIPPQPPSRQPNQPRLQVQTQITPPAQAPAIPARRQRFVPRSDVQYDPRTNVLTACLEMPGVRKDDLRVTLSTCLFNRVKQVVIQGLSQPVFPPATAQSQQGFSGASALSAHTSATPAVGVGHGAGTVPGGLAAPHERIEAANFSIRERKYGEFSRTFPVPSDTKPEDVQAVMEDGILTVRVACGIPALNSETYIIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNA6</accession>
    <name>A0A8H5GNA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNA6"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="355" mass="39299" checksum="D2D7BD1BCC2E3DF7" modified="2022-01-19" version="1">MSAIRTHQPVFDDHSEQKRFACDHDQCMKSFDRMGDLIRHKDVHNPEKPFICEWPGCYHGFRQKSNLMIHFRIHTGEKPLFCPDSVSCKFHTGDPSRLTRHRKSKHGHVPTRGLRKSTVSKPKGSTSHRRQAPQSLRSLPSSPSSSSCPSLSSSPSPSPSPLFSIHCFPATPITPVTESPEPLEYNATELCYPADTTPALPSPEISTPHKGIQHSAWDLNYAYSNEHLCFDTFPKMTYPAYQAGPGLEFDASGSSTTVVDAGAMYDMGGFNSDGYFTTYSSERWSDYQLDPLAFTNGPSDLAIGNYLSSMKPVDVGVETDFAFAPSPFELPFDSTLAAAMDELFMTPTSYPSMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP09</accession>
    <name>A0A8H5GP09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP09"/>
    <dbReference type="OrthoDB" id="3353871at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="207"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30481" checksum="59AFAE04D50F6BDE" modified="2022-01-19" version="1">MANHPLPPIPPIEGVDLTLSVFTHRSLGFQTADDPNNSERLATLGEKVLHLAVTDHFFRKRPTLSAEQIKVEVDRVLSDENYERWVDGYGLRQQLRAIPNTNPLENPRYNSMRRQFEIKLILVMQELQSYFQSYVAAVFLYSRMGTINIWVSQLIDPENPPPGPALPDYTQPPGYDSNAPPAPRAAPPPLPTTPQNFAGPSGSAVPISIAAFHEYAAKHSLQVAYQAESEGQSHLPVWTVRCYVNGEEKGFGQGKNQKAAKEEAVRRAWAAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPB7</accession>
    <name>A0A8H5GPB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPB7"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5368325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="271" mass="30922" checksum="D6447FF389545A37" modified="2022-01-19" version="1">MLSRVALRPAQVLRAVAARSSVSAFRSIHNSSSSRASASPFTESTSPNPTLTQYAQTTEQLHTYGSYLIQCLPKFIQQFSVLKDELTLYICPSGVVPVLTFLRDHSQCQFKSVMDISGVDFPEREKRFEVVYHLLSVKYGGRIRVKTYAGEGDAVPTSIEVFKGADWYEREAWDLFGILFEGHPDLRRILTDYGFEGHPLRKDFPLTGYTELRYDEERKRVVYEPLQLTQAFRNFESLSPWEQVGDGTKPVRPENLKPLPPPPPKTEEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPE0</accession>
    <name>A0A8H5GPE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPE0"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="523" mass="57053" checksum="9CEF0FC4F201DEE9" modified="2022-01-19" version="1">MSAIEIELQTGPEPNWEVSQDGADLHNVSASFVFPFALKQSRDKWLTSNMTKFSTKTTRGKVTENSSLPPHTVHARGKCDLEIGPHTFYETSFYEVHYFSPPATPQFTYTPQWSSYSSSVFPSTSTAGTTSAPLLSSMSPITINQTLVNQVDAAAASNPTLANLLQIAGRGEASEDQKKMLGLLIQSLATSPQVYAAATAAPPPRETDLVLEFQETPNERWIFPRGKSTCERVVDVSATDGTCDITLKCHTTLNRASTSGDSSTQPSSDEPKMLTLKFVKASPTIWDLLLRWIGGEQKNQENREALNKVVSPIFDFCARKTPNNLLIIESSATVISRVSSTRWTFTRPAESSTSDSRPERFATLIELMQVSELPYPMKSIRPSTTANSSRSRRKPSQKKPSEDSAPKRRKSTDIKTTTTTSESQSKDKPPGAAPKKPRQPKNKAPVVQIRCLTCNQADVPLMMGGRFCRPCVEAGKANPEVPPLQKGTGTSYVPLLYAPPTFVTAPTPVPSTTTPPLNPPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPJ8</accession>
    <name>A0A8H5GPJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPJ8"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39186" checksum="90DA111DD1D0BC7F" modified="2022-01-19" version="1">MIAFFTRSSSMSSTQKLTKKQKKAIAFRERKSKGPGSNKNANEDDMGGNEVPEMEIQEYGDGESVEMEVEDVEAENDGNEKKKKKNDKNNKNDAKSKSDSISKSKGSVNVLEKPNRKANAKDKDKDGNENAVVSAGKKRKRVDVEGEDGNEDEGNVEKLDGKPSKKKKSVDDKSRYILFVGNLKYTTSVEAIQSHFSACDPPPTVRLLTPKVTSSTKTVAKSKGCAFLEFSHPHALQQALKLHHSQLDGRSINVELTAGGGGNSESRLKKVKERNSKLIGQRTEKIGKKKKEDSGTSSHPQRFSATSGVEEAPDTKRTWSIGDAMDEKTHRGGKKHARPSKKSKSKDWGTGVNAIPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQD0</accession>
    <name>A0A8H5GQD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQD0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="162" mass="19023" checksum="9EAF4394FCBE6688" modified="2022-01-19" version="1">MSPTIIHEASSSIVQDALAWFLSHPASAVTAFFLVLLIVLFRRHYPCLSPPALEKSFKRLEDAIQTYKGECPRDYYHEFHDEFSILRGDVCSLTYTYFYGDWDPVWTLRYWKSRMDHIREVIACYKRCEDIHRSIQHAIELHRRQDFLSLGLQTNTASAYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR59</accession>
    <name>A0A8H5GR59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR59"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32666" checksum="D6072B823CDD1F8B" modified="2022-01-19" version="1">MLVVGLTGSIATGKSTVSNLLKTRYNVPVIDADVIAREVVEPGTKGLKKIVEEFGEDVLLDEPVGLGSDNTASTSSEPKPPKSWKTHPLNRKALGAIIFPDPVKRAKLNKIVHPAVRWKMFTEVLKCWIRGERWCVLDVPLLIEGGVWRFVAEVVLVWCPKEIQLSRLMTRDSSSAEEASSRLNAQMDIDAKVPYADTIIDNSEARDVLERRVEKWVRKVEMRVGGKRLVTIDVGTLSWKEGLRWCYGWSWWFLCWVVPPIGALKAVWVLASKAFRCWLYPPASKAKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRH0</accession>
    <name>A0A8H5GRH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRH0"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034178380" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="65"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="500" mass="53221" checksum="09BE0987B99897F6" modified="2022-01-19" version="1">MKGLTPSFLLSTSVLFSVANAVTLDLVGKRKQGSSLFFPRRLKRDAAGVFGNGSVALHNLGDTTYRSNVTLGGKDFEVIIDTGSLDLWVHGDVPGTKDLGIPMNITYADGTVQGNISTAQLQFDGFTIENQAYIRAEFTQDLEDVNGIIGLGPSGGSEVVRLLQSSAGDPPLDRIFQSNPSTPNILTFLLSRNATAETSDTAPLSEQYPAQLTIGTTIPGLETITNAPKLPVLINQSGEDQHWMTLLDVDGIVANGKKISTSTAIRNPTNGTTDQLHVLFDSGFTFPQLPKTAVDAIYGDIPGAEFIKDGAAASPDLAGLENFYKIPCDYEVNVSFFFAGQEFPVSPLDLSFGGPTSTGEDVCISLYQPIDDDIAGNPDFGAFDVILGMGFLRNTYILINFGDFVDGSTSNVADPYIQLLSISDKAKIHQDFVNARLGANGNETETENGNGNALGNGNETGNNEDSKGNGALSFWDSTVSSVSLTVGVTLFSALMVFFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS19</accession>
    <name>A0A8H5GS19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS19"/>
    <dbReference type="OrthoDB" id="2693038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="37995" checksum="5EDDD459647CB116" modified="2022-01-19" version="1">MMQVMNKRQVLGGGGILGGIGDGLSSIGGALTSGVGELTSAILPPASTTTSTSATTSTTPSQTEETSTTPIVIPTSISTSSTSSTTSSSTSSTSATTSSSSSSSSSSSSSSSESTTSSTPSATPSPSEAVVTSDGQPLTITSFVSPTSSAAAESSTTVAPSGKSFLQNKPVSGAVFGIVGLIGLILIFILTTWGIRRARRKQLMNEAMSFDPASHAYSDNMEQGLTEKRMSLGSTHSGSGGGSSYGHGNFPPGGYYGAAAAAPPPMPTSYGRPNYLNYAPPQRSPTTGSNYNNYNNYGAAADFSKQLPQVPNVAYDAGRGPYPQMNYGQSSPPPAEARSQPTLLPQTFGDHDADERAQTFGSNLKVNYSELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSE0</accession>
    <name>A0A8H5GSE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSE0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="75"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="531" mass="59133" checksum="D15B8C5DED1066F4" modified="2022-01-19" version="1">MSAQKSTNDNVPQYIEDVEKDLYSVQSASTRNELPRGIDSEVAQFFAQNGTDASKPIVIDEATNKRLRTMIHKRVLVVLVVTYFAQTLDKGTINFASIMGIREDTHLVGQQYAWLTTCVYIAILVWEFPANRLIQRLPIGKYLAFNIAAWGAVLACTAACHNFTGLVIVRTLLGVFECVCQPAFVFLSTMWYTREEQAMVIGAFYSMNGFQQCVGGLISYGISQIKGAAIKNWQILFTLLGCITFVWGIFVAFWLPDSPMRATCFSKEDRILIAERVRKNETGIQNKEFKMHQVMEALRDPTVWAVTLISFTNALPTGGLGAFSNIILNAFGFTVLQTYLLAIAQGAIIMSFLFSAAYLSGRFNQKLLLAFIYTLPNIAGTIVFLIVPTNASTKVGLLIAFYCTQGFGAVATLNLAVMSNNIAGRTKQVIASTFVFVAWAVGNAVGPQVFRDNDGPRYIKAFIAHIVIYGVQLVAIVLLRMHLMRQNVLKRRAQAKKVTHASGEDRDENIAHDRAFDDLTDKENPDFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT94</accession>
    <name>A0A8H5GT94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT94"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034125898" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="12"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="39302" checksum="D3D13E7FF93C57A6" modified="2022-01-19" version="1">MFSIPYGPFVLLSFSFLPIVIAQQQPQVFQIPPVIPPVLHALQCEYRGHDFLSWIWNTFDDPTHGRVNYIDKATALASNLTFASDDKFIMRTDSTSFVPSASRGRNSNRIQSPDAFGNSILVLDVQHMPTGCATWPAFWTVSQGGPWPTGGEIDIIEGQFMYFLFSFYVTQGFIGVNLNTMNLASLHTLPQCAMPPIRAQTGQTVSTDCDSAVNYNQGCGVSSSNPRSYGPGFNACGGGWYVMERSDIGVKIWFFSRCEVASVPLEVQSLYSPTISTLAWPQPDAFFPFGENCSYNDHFDPHSIIFDTTLCGDWAGTAFATSGCGAAQCSDYVDQNPGAFVDSFWEINYLRVYLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU60</accession>
    <name>A0A8H5GU60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU60"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="412"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5371269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="562" mass="63949" checksum="6A335DDCC7C27C62" modified="2022-01-19" version="1">MRASKEMSEVPDNYVSYTLKNTKPLPPITLRTLHKELEYVSLVAIIVPPIVSLIGAYYVPLQRKTAIWSIIYYFCTGLGITAGYHRLWSHRCYNASSPLRLILAILGAGAVQGSIKWWSRGHRSHHRYTDTPLDPYNASEGFWWSHIGWILVKPRIRQGVADVRDLKKDWVVRWQHSNFVSLLLTMAFLFPTVVAWIGWGDAMGGLVYAGFLRLVFVHHSTFCVNSLAHWLGETPFDDKHTPKDHMITAFVTVGEGYHNFHHQVGLDSAPLSPVLTSILLLFFLLLFLHFFLNRTKQFPTDYRNAIKWYQYDPTKWFIYLCSLFRLASNLRTFPSNEIKKGILTMQMKKLREVQSGIEWPAEINRGGDEANEIWSWEKFQSTSLTRPLILISGYIHDVSFFLNTNLPGGGMDHPGGQHLINKFIGKDATTAFFGGVYEHSNAAHNLLAMKRVAILQGGHPHALDMKIRSKPSDLSTPTTSPESPASVPDDNINDIDMNRLIPPSQRLKIVDYSDFAASLLHSQRSQSSSSWAKLVTLSGLHLQEKEKEQEDGTRRVWQYDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUC3</accession>
    <name>A0A8H5GUC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004283</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUC3"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="88"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="213"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5371217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="437" mass="49412" checksum="D50169DD14AD84F7" modified="2022-01-19" version="1">MNLYPAGLYRPGVDFDDSQSKTQVRDLTGIFHRVFGGDHSGLCRFPLSVDMVYKPLSSLDPEKTRKASEITCSLFDIPSLRVYQEPAGQNVLLGKDTFLDIPTGGSKTLAFYYPLFYHWQPRMMDADTQKILLVIEPLSGLLQAQANQLNKKGVPAISLTGETDKLSDTLKLSDVLSQGFGNGKYRVGFVGPEMALSRCLPSQLHTLVASATVPPDVIADIRDKLGMGSPQDFPQTLIYVNGRQEVERIQDFLRQYCPDCIPKTSFEFYHRFVANDRKRDIEKRLYDEILRGVPVTDALGMGLDFQCIKQIILWNEPWTFNSLIQKIGRCVCIFTDLGEAIVYITKAALSRFLAEFNMSHYEDELDLGADNLRELEWKDQEVEEDVEIDAVEVFKSRQEHESGVSMSSEHSVAQNSGNSKKQQVKCKRVLTRIEAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUI7</accession>
    <name>A0A8H5GUI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUI7"/>
    <dbReference type="OrthoDB" id="3045817at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="23539" checksum="E4BFCBCD20EAC544" modified="2022-01-19" version="1">MIMLWHTQRTTESSPINVVRPAGISPDAKLPTVAQWIFGGGFELGSPQMYDGATIVSRSIELNELLIYVLMSYRVTAFGFLASQEVKGASIGNLGLQDPLSHSDAILHKSSSEKTLSVATAVEHMQSNGNGSGRLSSTITERRMNSLRNELVFGTKSLRSQSDTETKGYYYRTQVHVFSFLASFKLVLIVSISSIPPDYDALVDQTAFSASDNAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX03</accession>
    <name>A0A8H5GX03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX03"/>
    <dbReference type="OrthoDB" id="3033163at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="35529" checksum="F611C2979C6300F2" modified="2022-01-19" version="1">MFTAKPTLYETENSRVTFASSYLTGAAARYYQNLIEREVMEGVYLVALHNWQAFVGTFGRLFGVHDEQLYSQAALDKVLQRADENFADFLVRFEDASLLTQYNEPVLRWRLLLQIRRDLRNRLTLVGRIPRGFNDVVDRLLDLDTAREAFNEAGLATNNYANPTYVPNVAPVARARNNQQNAVVVPGPITQANRNRPRANQNQNLVTGRTAQPQPLGNRPFVRLTREERDRRMKNGLCIRCGASGHFGRDCPPENDPAPAEEAIARAGIIIEEGEVETYYGYDEEGNIHELDREEEEQGNEERAQDELPEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXZ8</accession>
    <name>A0A8H5GXZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXZ8"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034653771" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="35"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="427" mass="45831" checksum="63FBDA826E3FE713" modified="2022-01-19" version="1">MPRITQAAALLSTVSLAITQIAAQSCPTIDPAHAPVMATGYESRVVLNGLKSPRHLVFDTLGNLLIAEQDQVGIRYVKLTDNGGLDICAESSEVIIPDTTLNHGIDLSPDGSILYVSSKTDVYAYPYDAARATVGTAKHLITIPDQEDHVTRTLTISRRYPELLLVSRGSNANIDPGTTDIESGRSQIRIFNLTEIGDEPVPYTDGEVLGWGLRNSVGVTENPVTGDIWSVENSADEVARDNVDVHQTNPAEELNYHGNLTGASPVHGANFGYPLCVTAWDPSAFTTTTAPSLTVGTPFVIGTTNDTVTDEMCQTETTPPKISFPAHTAPLDVKFKADASAVYIAFHGSWNRDSPDGYRLSRVNFTTDGFPIEPSDSSTAEIRVMTNQNNTACPDGCFRPVGLAWDSKGRLFLTSDATGEVFVITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY13</accession>
    <name>A0A8H5GY13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY13"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="37385" checksum="FDB2B3F7DD59E020" modified="2022-01-19" version="1">MSFPSTTRQYYLPEIGSYKNLKLVEAQLTPPKSFEVLVKIHAVSLQFRDLVISKGTYPAPLTKDLVPCSDMAGEIVWVGEDVPDGWKVGDRVSANFCADHIDGDATPEIQKTAHGGMIHGMLTEYKAFRPHSLVKIPDHLSFEEASTLPCAALTAYNALMGPVPLKGGDTVLVLGTGGVSIHALQIAVASGAEVIATSSSDDKLKIAKKLGAKHVINYKTTPDWDKEVLHLTNGRGVDHVIEVSGNATLPKSMNAARVAGWIHIIGFVGGGEATDIIVSTIKKGAIIRGIQIGSVRQFKEMIRLFSAKPEVTRPYVDKVFPFDKAIDAYAYLESQAHFGKVVIRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZI2</accession>
    <name>A0A8H5GZI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZI2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="21835" checksum="B674CE91251A0881" modified="2022-01-19" version="1">MGYELSPHEPSVEEAMTSCACGQYTNLKALFLVFFVVALVILVVRLRHPCLTVSSLERFIADLQCSLTRTLEDERRPSGTTTVADLYDDLDKIRHLCEDIVKQKNGNVFRWSLLHRYMTMTFNVLRNVLKCSDEAQVLEVKIKNCCVAVSSEHGTVSPSSPSATTLSTGIELRNTQSAAGTESSGIGSRLGTGTQTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1W4</accession>
    <name>A0A8H5H1W4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1W4"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="2">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="402" mass="45661" checksum="CE2F2AB89F39C15E" modified="2022-01-19" version="1">MSTLALPPPSLAEDDVVDAARQRVAPKRKSRLSASLPNLKAAFHRSSKPRQAESLAEDEPPTTEYSTTSGPERAITFENVSSSADYDPFQDIYRWAVLYENQRGMTIFSIPLYSSSALLPADPAPFTLPSSSSQSRSHLPNVSIAEYPLPDGNWHWVSNSWMIDMRYSGEVQYDGFEYNWNFRKGHWRPDVGLLSAGGWVRRRRWIRLMMRPGLKRRHGPDEDTLTTPVSSSSRRNSLIADLFERRLSGAPSIPSVSTILESSEEILELGVGDVEEDWKMCRQLMKVIGRSDGGRLELWKRWLGLTKEDVKEKGKERDDDVQDMDAPEDPNTLFNCVKAVIDAHGPEILQLFVYPESKRRFIELLTEANIRLQDVDESLLRALQFRSLTSGLDLHACDHEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK07</accession>
    <name>A0A8H5LK07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK07"/>
    <dbReference type="OrthoDB" id="3016506at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="510" mass="57137" checksum="93D0A17B3BC3E9DA" modified="2022-01-19" version="1">MTARKARLKADSFERLLAKARKNGLSTRKAWHYTKPHKCNPKSNEEKAIEKAARDAKKKTYSERLQECMGQVYRMAEGLAEEFGKHDAGYYYTEIMQVHRLTEKKKDPNAFQAFVSMRVEEINKDIPEGENRRKVGECITDIAKEWNELSTEEKKERTADALASHNTPLAVFHDTRSTLEEVKLVLQRLNSRTGCEALLIAVRSNSGHYNPADSWGTSPRVLEFFNISYREQTDKMAHRLEGYCVSGLEGVAHNYQRELSGMKSGVVNLILSKLKEAGGKTKISRMFYSNFDEHITARYGIIIKGWPLNRFCSPSDLNTRSEVDILRNAWENNTCTFYKMTETEWKEWEKKRFEEKVAESSAQTTPGDVHDTGSEPPPNNDAGCEPARPSGSSPGATSTSPPEDAPASSANGPEPLPSCQQVLTQQTPLQQIQPPALPVDQSQPKRRGRKPKEGGQVANATFVNSSAIIGANGEVTMNVPKRKTRKDKGEARKKQRTSTGEEGLTVSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMQ3</accession>
    <name>A0A8H5LMQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMQ3"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5362856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="26724" checksum="F23528F5301CC91F" modified="2022-01-19" version="1">MSSTEVPFKISVPDDQLDLLRKKLDLITPTNSRTLSGDGYDWRAEESKLNEELPQFTRDIEVTGHGTLNIHYVHKKSEVENAIPLLFVHRWPSSFIEVRKILPLLVQASPNGKSLSFHVVALRLPGYGISEAPRKPGFVIEQHVEVGHKLIVVLRYNEYGEVGKDIVPGVQMMGCLRYFITLTLSPQPPFSPQTTIFPALLPCPPLSPPSAASLYHSTNTLSYFFSFRNLKRDSGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMU2</accession>
    <name>A0A8H5LMU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMU2"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034672916" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="82"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5362976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="482" mass="53972" checksum="584475F71ED805BA" modified="2022-01-19" version="1">MCSLSLLLAAGFWCLSTVAATATRPDKIYGVNLGSWLLIENWMLPAEWERMGGERCDDCSTCISSEFEFAKAYPDTVDEMFEEHWNTWFNQNDVDELVSLGINTVRIPLGYWIVESLVNRDLEFFPRGGINQLARGLKQLKEAGIVAILDHHALPGAAAINQLFAGQCTNSPQFYHRFNYNRALIWAAVMTGLSHLHPDFSTVFSIHAINEPIMNASRTPGHGDYQRKFVKTVRAMESLLGIGTFDGTYKAKRGEDLLYISVDVGLAFSSSTKENCPFGDVCDVIIEALPILGEVLDQLGSLELSSVFGLVGQPPLETNFMDVTWQYNNPPNAADIAMGPQSYDNHLYYNFGGVADPNPKAYLTHLCNLDRVENAVKNRNVPLWFGEWSLATNFNETNTTDAFLRDWADAQKLQYGKDAGWIFWNFKIENSTLAGETARQWSYTEGVRRGYFTRDPAAYHNASVCEQYIIRNSTTNSTSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQG7</accession>
    <name>A0A8H5LQG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQG7"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33604" checksum="E3C9ED2A4F569FC2" modified="2022-01-19" version="1">MTLTRNAFLPLVITRGSDQVAISSRFEVRNDPAVVRNFGSILIEYSKIVPDGIVAFFPSYLYMESIVAAWNDMGILNEVWKNKLIFVETPDANETSIALENYRRACDNGRGAVLLSVARGKVSEGIDFDHNYGRAVIMFGVPYQYTESRILKARLEYLRDAYRIRESEFLGFDAMRNAAQCVGRVLRGKTDWGLMVFADKRFARADKRAKLPRWINQYITETASNLSTDMALTLSKLFMRTISQNPNENQTGVSLWTLEDIEKAQAKQAAAAAEEKNDEEDEYGDGGISDSMLADMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTD4</accession>
    <name>A0A8H5LTD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTD4"/>
    <dbReference type="OrthoDB" id="3256745at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="56845" checksum="4B2A2D4B71FF4D66" modified="2022-01-19" version="1">MVLSISLRSLGSLGCAWKAFQKVVLGTVTVWSRMYIIARYILHWPRLAYGSLSYASSFLHRCHSSDLETLPFIELSFNSSNAPYWFFKLVFDRNLHYPFFCFEFNLLEGNRFLSWRTIYAIPVLVFPLAGTAAQAIAIFRLDAVNPFDGLDCDARNPSWVRFLGYAGLPLLFAFPVFCFSIGTIIHGVKRRTSRPPDVIWNVNSDSFTTLRPRRTHYKDFRRYATTPPLPRVLQSPSPNTQLQYAISPGRAPISPTLSSPVLTARQFHLPFSPLFSQEGQAQPSHQSQSHSASSLQGTDSRPVSSLFPTFAPASLSESPNSISTHHGPADFMSYLYYRDDWKDPSGNHSPPRERERSRTPSSIRWNHEIEIEDSDELGETVESEEHKEMYKFTRDRPRQLTPNDLNMSYTGAPRSIPSPIVNDRLPQGHSPSSLNDTVPNVLILIISQLSFFVTLLLACITPLIDAITYRNPPSRFGTQHVALLFSVWIPVIIIGCSKLWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTF1</accession>
    <name>A0A8H5LTF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTF1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5368917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62575" checksum="40059153EA53022B" modified="2022-01-19" version="1">MSQLQEYFSGFSFTPASVAGIALSAFFLVHFIPWLVDPRGLRSLPGPFLAKFSDIWLGVISLQRHRSENVHELHQKYGTFVRIAPNHISVAAPDALGTIYAHGNGALKSEFYDAFVSIERGLFNTRDRNEHSRKRKTIAHIFSQKSVIEFEPQIRLYVSQFLDQWSRLYDLAVQGKHGDEGESGWEGHDGRLWLDCLPWCNYLAFDVIGDLAFGAPFGMLSACQDKAPVPVSQKAAIESYGASQTIETREIPAVKILNGRGEYSMSLGSLPPHWRPIAKKLPWFTQGGKDVKALAGIAIMAVRRRLAADAGIDVEKEKVAGGDGAAYRAGGRNDLLRKLQEGKDDQGNPMGREELTAEALTLLIAGSDTTSNSTCAIIYYLASNPEAQAKLHAELDAALDPTAPATVENVKNGKLPYLDACIDEGLRIHSTSALGLPRIVPEGGLTIDDPLTGKSQFFQPGIVVSVPSFTIHRDPTVWGADVENFRPERWFEGGKEAKELRSRTFNPFSVGPRGCVGKNLAYLELQIIVGSILRKFEFVLEKEGQKLETAEGFLRKPLGCRVGIKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUF1</accession>
    <name>A0A8H5LUF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUF1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034946673" description="Peptide hydrolase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="177"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="426" mass="47266" checksum="68F02C41E6F92800" modified="2022-01-19" version="1">MKLLSILPFVALAIAGPLDFSGQAPLAVEDSFDLDLNERRLIQLEGHDPLWMSERDKARINLKAQGIKFFDITDTQELHFTASPAMNTQRTYPAPNSTEKVRPILKTLSSDGPKKNLEKFTSFRTRHYRSDTGKQSQQWLLSKISEITAEYAGQAMKDRVLIHEYNHPWGQNSIVQIARIQGSSTTDDGVVIISAHQDSTNLWPFLPAPGADGMQFTPDILYVDIDQSFPEDDGSGSVTILESYRALIAADFQPVNSVEFHWYSAEEGGLLGSQAVAKSYQADGVNVIAMSQFDMTAWVKRGTNEEVGVITDYTDPALTNFNKQLIETYLDIPFVETKCGYACSDHASWGKAGYPSVFTIGALISSGLLKPTSFLFNAESSFENSNKNIHSTNDRIDISDEFSFSHMLEFSKLAVAFAVELGGWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUU9</accession>
    <name>A0A8H5LUU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUU9"/>
    <dbReference type="OrthoDB" id="3224413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="87"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="230" mass="25806" checksum="AAF7ED3103E78712" modified="2022-01-19" version="1">MTKQVRFAPENRLYSPKPFEKPLLVVGMAASQQSSTSSSSSATSQSSDKLKARSRAGSIPSPLIIPETPTRLHYLLAYLPFQHPAVFYDLSLHPSILERLHPATTLSESATDPPMASMIVTCPHLNWELHIAPSTGSMRPYISVADVFRALYSGLRKAVHPMEYEALPSYHALHVNQAYFTRCGFILDDYVRMEEQKKGVKRVDFLLGRNRFLGLSSRKGDSRVWELNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV99</accession>
    <name>A0A8H5LV99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV99"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="27374" checksum="75621238665D55B7" modified="2022-01-19" version="1">MTTANLQSNDIIHSRISVNCKQFLETEDVRWVDGIAGLKVYETTADMLERLLSHNDRIPLLPLVKLFFVKYLYPAHSPSSISESLTRFHSRSAPGISILDYLKRIVKFTKVEVGGISLSELNTLEKEFLSMIDWRLTCTRELLEEYYINLVRTHSSGSFVIVGPPETSTSTEDSHNDVDMDARGTSRTPSIHEPSAIFADPSSLSIPSDVSRRPTIEQNMAFAALRDQQRQAEAGERAGASADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVL9</accession>
    <name>A0A8H5LVL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVL9"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="36945" checksum="667B330E18BEF79C" modified="2022-01-19" version="1">MSEQKALVLESKQGRFVVSTRPKPTSVPAGELLVKIKASALNPADWKVQDFGPAYIEKYPAVLGSDIAGDVETVGEGVTGFSKGDRVLCQSFFVNNEYAGFQQYTLVPAEIVAKIPENLSYSQAASVPLGLTTASVGLFSNEPTGLGLDPSFDLNVKHSGPVLVIGASTSVGQFSIQLLRLVKLSPIIAYASAHQFDYLKSLGATEFIDRKQVSFSDLPAAVKKITSEPIKLVYDAFSSAESEQAGYDILADGGTIIVTTGDQIKNKVDGKKVLDVLGSVHPPTNREFGKAQYRNLTKYLQDGTIVPNRTEELPNGLAGIPDGLERLKNNQVSGIKLISLPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWS6</accession>
    <name>A0A8H5LWS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWS6"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="965" mass="109541" checksum="635C96FA691EAD07" modified="2022-01-19" version="1">MDEDGLFPCGQCPKRFTTQRGWKQHQNYKHRPAADTPRFPTPNFRTPSPAPLSGPSSPIFSSRRSPRRRQNGSPVRLTWAAAPLELQRYGTQVTEHPILDGTPCDIYGDDLPEDTPPPALEPRDPEDYTPFGSADEFELAELLYERVQMSASNIDRLSQLIANLLGPDKDAPFLNHEELYKTIDRIKQGDIQWDSFTVKYNGELPDDLSTAPAWKLQEYEVWFRDPLSILEGMLANPSFKNELDVAPKRLVKNGKRLYRDLMTGNWAWFECDKISEDENTHGAMFAPVILGSDKTTVSVATGQNDYYPLYISLGNVHSSVRRAHRNAVALLGFLAIPKTSKDYAGSAEFRKFRRQLFHTSLEHVLSSLKPFMEKPRVTRCPDGHYRRVIYGLGPYIADYPEQALLACIVQNWCPRCTARPENLDRPAGRRSHEHTDTVSEGCSLKEVWDNYGIVADLKPFTAGFPRADIHELLAPDLLHQLVKGTFKDHLVDWVVEYINLTYDKSEAERRLADIDRRIMVTTPFPGLRHFHEGRGFKQWTGADSKGLMKASSFVFLPAIAGHVPVQMVQAVSDFLEFCYLVRRNVIDEDNLDAIDAAIARFHQNREIFRETGVRPDGFSPLPRQHSMVHYRHLIQQFGAPNGLCSSITESKHIKAVKRPWRRSSRNQPLGQMLVTNQRLDKLAAYRVDLECQCMLDPVKDRSNLPPPPPPPPPQEEDDEDTEESGDSDEPYSQGDVKLSTKAARGVPRDINTLAAYINQPTLPILLRQFLYTQQHLANGPQGCNVPLASCPELERNQKVFLHNSAKATFFAPSDMSGLGGMRHERIRSTTSWRRGPSRYDCVFMEGDQQEDGFGGLLVGRVFAFLRFTHEGRRYPCALIHWFSTVGNTPCEQTGLWRVVPDFDRNGDPVLEVVHLDCLYRGAHLIGVTGSRFIPDKDFTSANSLDMYQGFYVNKYVDYHAHEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7Q2</accession>
    <name>A0A8H5B7Q2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000451">
        <property type="protein sequence ID" value="KAF5318319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7Q2"/>
    <dbReference type="OrthoDB" id="3063460at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="74"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5318319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="286" mass="30361" checksum="C92754B088D3F216" modified="2022-01-19" version="1">MKGTPAECIGFGWSLKDLYVTPFTPPLTNQSTFHQWTIGPIYYSTLVMAEALGTTGSTQVMDLSVNDGNNYTPAYAIYKNNIPICVALINFMTDNSGASAYTMSISISGGNTGQPTSTPSSVKVKYLSTSNVSQKASFTWAGQTFGDYFASDGRPMGEESIQTIQCNLISNTCQISVPAPGFTLVFLNDKALEESTDGGNGEGGEVMTKMMNTATIDQEVLATSNGHRAGDLVGWMGSMSRRSSGVQAGRGVKGMDMSMVVMGMISMQVVGGCCWVGFGDGDRGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BHD5</accession>
    <name>A0A8H5BHD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000395">
        <property type="protein sequence ID" value="KAF5323214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BHD5"/>
    <dbReference type="OrthoDB" id="3172613at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="24189" checksum="054D017CCF0A5B1C" modified="2022-01-19" version="1">MWYYNPMATAYIKVLYSRSLDTSIDMGNNISASNVSAASDLEVRQKYRHFRVLVIGRANAGKTTLLKRVCNTTEEPCIYDEDNRNLLEPTADVNYWNLLMSLPTEFIDQRGVHNIHRAFAFASNPQFIFHDSPGFEKGGAKELEDVQQFIENRAKATNVEDQLHAVCIDRYFRFCLVTDAARPVLELEERFFREEAVWKCSSDRNIYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BHF8</accession>
    <name>A0A8H5BHF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">60S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000396">
        <property type="protein sequence ID" value="KAF5323196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BHF8"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5323196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54508" checksum="40AB277996996B83" modified="2022-01-19" version="1">MWYSMSFNDWPDGYAFILNFLAPLWTIGSFDSSVHISEEASNAATAVPWAIVYAIGIAGVLGWADHLRMNGGSAINMALAFCMGTDLEALANAGQPMAAIFFNAFGTKGTLALWAFVVLVQYMMGSSMFRMTYKISGKPTLLAETETLKPCVPLSLTLRMTALPFSGWLYRMNGYTKTPVNTVVFDAFLALLLGLLVFAGDQAINAVFAISVTGLYIAYAIPIAARFAGDNDFEPGPFTLGVFSLPVAIVAVVFMLFLGIVFFSPTSPQTDVQDMNYTIVVLGGVMILSLVWYYFPKYGGVHWFKGPVATIEGFDDSSALKNRKRGNVVDETEMPATVAEESSLENQDKYKKLPLQCVPIQAIREEASNSPASGTKFRLTLGLPVGAVINCCDNSGAKSLFLIEPYGFGAHLNRLPDAGVGDMVVASVKKGKPELRKKTMPAIIVRQRKAWRRRDGVFLHFEDNAGVIVNPKGEMKGSAITGPVAKECADLWPRIASNAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXB4</accession>
    <name>A0A8H5BXB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXB4"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5330082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="42053" checksum="0DA78EA08191D08A" modified="2022-01-19" version="1">MSPQSAFPLWTNDRTELFEVEQLVRKNSDCQWRQARTNRWLGFGPRHTVGNYVIELSLNVNVNASSVPIRRPNNHKQQRGIPDSETTPLTAKCARNFRADGICCKELKADVVRDVLIGLIVPFAVTARLSSLGASSLVTELIAGAISVGIGEFLASQAEHDHYRYLKNQTASWVIRSCAGTCRAVVKALREGGTPEQRQRSEETGGGLRWSKDVGLTALLLKFGQGLEVPIPRLYISVFTIGLGYLIGGLIPLFPYFFIPQASTALVYSCVVTGVVLLVFDAIKPQGSDRYFYFTLLYSTLLYSAILSDPRLCAFISPILFRLYLLYVLAFILFYPLSPSAKPSSNTHVNRSPEHTHPTLSLASGKVSFGVQCRLYSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXK5</accession>
    <name>A0A8H5BXK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000329">
        <property type="protein sequence ID" value="KAF5331290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXK5"/>
    <dbReference type="OrthoDB" id="3049395at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5331290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="582" mass="64408" checksum="86729DBF4F9D467D" modified="2022-01-19" version="1">MVISKCVVGDQSNDCAHLYAILLALQLTPANCALHIHSSSEYLINSLTYWAPRHAKTGWACTNSDLLSAIALWIASRPAPVKLFKVKSHSVSLHLDKVTQLAKSPCDLPLPHLGGVDDLSCTPPPPHFCPPPNSLTQPKLSTNLEPRSPPSRQPTGTASHNASFGQLNAHGRSLRHLLQMAMRDRIVEASVSPAAFWKLYKKLYQECFRSGKVPTAWLITLLSALPKHGRDLSCPDNYCAIALESYFLKFGTLIVLHKLTKAAEDGNLIPASQNGFHTGHRTHNNTFILRSLIECARSRDISNVFPLTNHNALWNRLEDLGLTGMYYNWLCNLYRDMCYRLVQGDNVSEDFEAGSGVLMGDPASPLLWNLYLSSFQLASHADNMTIDGTTISHLEHADDMLEEWCFNNFLSLSPSKSEVMIFGDLCNTLAHLRQTDLIAYICGLSTSSTSPFIFTVNSCLLKLTDKFKYVGTTFCSTERDIFTHLYDEKANAATISSHGILSTEHLVGWGRIPPHSAKTLYTALIDCHLIFGCEIALDVTNTGIQKLEKVQNGFLRLILGLSRSSPLPPLFTETGIHPLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYR8</accession>
    <name>A0A8H5BYR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYR8"/>
    <dbReference type="OrthoDB" id="3228777at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="377" mass="41407" checksum="DFF3C25CAF90918B" modified="2022-01-19" version="1" fragment="single">MTDKTQNDTPFSRLSRMGFSLFKSQPTSPRNRDSGKAVDDDENWYIPYNGPYEAPRRQPRQEKDRDSWGDPVDGEDDVVDILGDPELRNRYGGHGEEEERKARSRARAQSAASGRTVSSGAIDPSRNNTATPRRSTVSQTSRPVVPSFVDLDTAGGVGESPIPTGRYSKDSNSAKRKNSFTSLFTFNTVKRTTSSTKGLVSSPTSPSSGSSEVQGRHGQLYPPPSMRRLPSDPVAAEQTLRSSGPDEQDYYNSYYSTLIRVPSEQDFDSNNDGKPSQLRSSASETSSALHPYAYRITTPPTPPQPPHSAPIFPSSTARAANGSTQISPPPMQMRHSPHVMLHPPTNHPLKNSVSTPNLRQRSKPLLAKGKDKWLSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2V1</accession>
    <name>A0A8H5C2V1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000266">
        <property type="protein sequence ID" value="KAF5334160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2V1"/>
    <dbReference type="OrthoDB" id="3365519at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="944" mass="102781" checksum="C2F636721E0A4D81" modified="2022-01-19" version="1">MFSILKDRFCLQSESTSSSSHLISNSLQGSPAQTSYSFITPRSFTDPSTATSATSSASPDSVTSNPNFASSSHLSNSAHEHIKLQTSPSLSGNMLAVSNTSVRGSFGALTDTYPSFPSQSMTSQPASGMMPQFANFQYYSPNMMMPNGTGMSNPFILAAMIDGSGRSFPLDLSMMQQHMLNPPHSLSRSPSFPGKAIVSGSPYPPPRHHSSKNVNPSQQPGRSSGKNSHIPSSATPSSPVTFRETATPGLRAQRQGQLHIPEAKSSHVTSRGIPHNHRHDKSSRAHPPVTFSLAHTGVNGSKRLSSSSGSLRTPSLENRRLSSSSSDSQSHRYSGSSRHSFGSWSSHQHIVNCETPITPNVSAKPVAAVQTSTSNQPPAALVQASKDSEPLEAASKARDTNVDSADGGKSGSKVEFGDLVEKEGSIMKVDEKGGSTVTVDEAPVSGEVEPEAHVTLGPEAEQSSTTPLSSLALALPPARDDDCDSLSSGVETELTSSTSAVEEEISERCPPTYFPITLFLSKPDLLASLLPRSTMMLTGNELLKEEVLERFLGPVGYSQWTWREPEPISLTLRDLHDYMRCILVPIHEYTRIAESYLKQQKMPQAKRDSDVLQSAVLLRDATRAYNRVLLRIRAQAEKDPDLFMSNSTLRLSCATQSPDPPIQAPNPPLFRLRHAPLLRVFIPSPGGDWLSDSSVQQCEAELKYAEVTKLLRMGDVVWDIAVGDNGNFGRMVWDGQYLIDLDYTYSDVGDVPKYIPSLAFPPSYFHRVLRTNSSSSDPIVRLDISPWGEEIASNLQLLQNKNKGIPQAACHSTNWIHQSSFTIRSPRARSLASKRSEKTGQSSKSTESSHGVPIPGFQGLFVDSGWYGKIVIETEGTGDSLADLQDRCGPGAFPSRVQSSARSMITGRSMQREKDARKVFRIIRERSHPGELWLRAVSSKERRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3I2</accession>
    <name>A0A8H5C3I2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3I2"/>
    <dbReference type="OrthoDB" id="2576233at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="97184" checksum="59815D2018370E55" modified="2022-01-19" version="1">MSPAPLTDPLCQEYARTLRNTTSSSDALADFLKNFGAQSSPRTLRVDPQGDHFGDYNCLDESTDVNFGTGGPIIVDNGDTGDECPSHHDSSTDTEDSDADDWDDEEAAAAAECERDWEAEVEKEEMYWTGVQDMMESEDDMETVLDALQVPVSRPPQLRETDILREPFIQHYPDPRVGAPLPSQTTHLNANEAYQQALGHNANIWTPFISEIDWRVAKWAKMRGPSSTALSELLAINGVSERLGLSFKTAAELNKIIDKNLPSRPRFQRQEVVVKGEVFEVFFRDILQCVKALYNDPEFAPYLKFAPERHFENETLSEQLFHDMYTGQWWWSTQEALDNTLGPGRTILPLIISSDKTQVTTFRNKTAYPVYLSLGNIPKEIHRKPSKRAYVLLGYLPSTRLEHIQSPTSCRRCLANLFHACMKHIVRPIVEAGTSGIVMTSGDGVDRLTHPIFAVYIGDYPEQILVTCGITGFCPRCTIPRQRVGENLEPHPIRSLAAILHALAKIDEDASTFVRACKEAGIRPVFEPFWVDLPYSNVFLTITPDILHQLYQGVFKHLKSWVIKAYGAHEIDARCRRLPPNHNIRIFMKGISSLSCVTGQEHDQIARFLLGIIADASLPGGMSSARLLRCLRGLIDFLFLAQYPVHSDKTLALMDDALRQFHENKSLFCDLAIRSDFHIPKIHFLNHYTESVRMMGSFDNFNTEYTERLHIDYTKDAYRATNKKDEYPQMTTWLERREKVMSHEAHVGWRLSQRQPVLRLHWIPPGLNTTRILHMTKHPSVCSVKLPDLVDKYGATFFSDAMSRFLVELAHPELSRRRLQDEIDYHFLGISSVQVFHRVKFLRHDFFHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3R0</accession>
    <name>A0A8H5C3R0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000260">
        <property type="protein sequence ID" value="KAF5334428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3R0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="19700" checksum="2417482429C482BF" modified="2022-01-19" version="1">MAVVAYPWSNYYVSPLNLDCSEHAYAPSACYFPPVLPYYYPLNPYGQAFHSTLDYGLENGHYPTWDHGMALRNSYSEMEVSPFSAQGFRLVQKHLACEVVIKHLEAKYEAEKQKVDMVTQRLKDVEAESMMVKCEAWHAHKRIDELESELEALRASLRCGRDSVVNDELSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3T3</accession>
    <name>A0A8H5C3T3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000253">
        <property type="protein sequence ID" value="KAF5334725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3T3"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5334725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="669" mass="73128" checksum="1CC20D48FABFC78E" modified="2022-01-19" version="1">MNSGTFCKRLIYKNSDVTERHASQNEDNNSIVPAAGQPTIGILQGARHLSMKDNTINVVAGNQDNRAYHYYGFQQDIINKLNPSTSALHEVGQRAECIEGTRKEILDNIMNWAGDGSSTTMTGYWMCGMAGTGKSTIAQSVCLGLKRKGLLGGEFFCSRQIEECHDYHKVIPTIAYQLASRNAKYQQALCDVLNEDLQLASKEPQYQVTKLLIDPWKRVVSRGESPFLAPVIVIDALDECRDISLVLEFIVPAIKKQELPGLKFFLTSRPEQHIKKHFDLDAIQQERLYVQKFYLHNVEKSIVKKDISLFLGKGLIGLGISKDKLDILVERSGALFIYAATLVKYLASGSEVEGISVSPDGTRIVSGSKDGTVRIWDAQTGTAIGEPFQGHEEWVQSVAFSPDGARIVSGSDDRTVRIWDAQTGTAIGEPLQGHESSVQSVAFSPDGARIVSGSGDRTVRIWDAQTGTAIGEPLQGHKSSVESVAFSPDGARIVSGSGDTTVRIWDAQTGTAIGEPLQGHEYWVQSVAFSPDGARIVSGSDDRTGEPLQGHQKFVQSVAFSSSGAQILSGSSDRAVTNPRTGPTLSCKYNNWTIDKDGWIQFPGIHCGIVWIQPQYCPTLCTSQNPVIISRKGCTKLSFDEIWDDRPYTNTILVIPQSQQLHGKGSGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4E2</accession>
    <name>A0A8H5C4E2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000261">
        <property type="protein sequence ID" value="KAF5334351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4E2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="86" mass="9907" checksum="9B1984977365638D" modified="2022-01-19" version="1">MENLSSIHPRNLIFLLTLPWLSLFSVSRVAVFHSQMTKRSMKTGRGTGTRNNVIENHGHWKEVDRARRKILIFFGIHHSLSADSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4R2</accession>
    <name>A0A8H5C4R2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000277">
        <property type="protein sequence ID" value="KAF5333952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4R2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="106" mass="11724" checksum="3189D1E20A3E0258" modified="2022-01-19" version="1">MRGRSRGVSYTEGAGKTTDEENLRRRRRSVLFGLGAEVYNDGYQRVKNLMDPNNANVLITRVKPTQFLLASPHPVSLDKLTAGQIDITGAPIYLPAPLRSISGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C652</accession>
    <name>A0A8H5C652_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010078</name>
        <name evidence="2" type="ORF">D9758_014301</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C652"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15725" checksum="013C579A7AA378A9" modified="2022-01-19" version="1">MLIAQGAHTSSSPFLKIIVTGSFGTLPPFTYMRATPADAPTLLKEVDSATRPLDEAPAPLLSTGTTLENTPADPLHTLVTPKEKPLIPDEFYLSLQPPPDAETTNNEITINETEPKERVRRRRGGRGKVEKRENRRHGSTTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFA5</accession>
    <name>A0A8H5CFA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFA5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034261781" evidence="4">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5340443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="232" mass="25318" checksum="C21C2804432FD509" modified="2022-01-19" version="1">MIKLQLYTILLSLFALLVQCPVLVSASTQPKNLLAHGYFLAESVCGPADSPMSDLVNLSSMAALEEATFGDYKKGSVSMTFESSNNSAISGSAADTEWDSFFPKNKGFISQDIENNTVLYSISGFHAMHCLDTARRVLEVHYNVASNASKTKVNNDAVYGSYYHIHHCLIYLREMVTCTADPALEHHIYFANGTASFGGDGTKHECRDFNALYNISDQSHEAAKMACGGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CH41</accession>
    <name>A0A8H5CH41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CH41"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034881305" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15021" checksum="940923A20F62A626" modified="2022-01-19" version="1">MHFTALVATVAAAALPALAANFDVEVGANNGFVYAPTSISGAVAGDTITFTFTSRNHTATTTTFNDPCTPPAGGFGTGGFDTGFHDTTSGPQVAVITLQDSDTHFVACRQAAGAHCHAGMTFAINPTDDQTYAEFLQNALNDPVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CIM9</accession>
    <name>A0A8H5CIM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CIM9"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5341483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57780" checksum="4FDE7E46E5E8D53B" modified="2022-01-19" version="1">MTSHDDHRNESLDDQDVLARLGYKQELRRDFSRIELFGLSFSIVGVVQSIAAVLLYSIPYGGPVGMIWGWFTCCVFLVFVGMAMSELGSAAPTAGGLYYWTFKFSSARYRHYLSWLIGYVNTAAYVAGVASINWGCATQIMAAVTIASNGSFAPTNGQIYGVYCGLLVLHAIMGSLATRIIAKLQYFYVFLNLALFLTVIIALPVATPSQFVNKASYAFGHFENVSGWNNGYAFILSFLAPAWTVGGFDSSVHISEEARNAPRAVPFAIMCATVFGSFLGWIVNIVLAFHIGNDLESVIANPIGQPMATIFANSVGRTGTVIIWAFMVITFFMTAMDYLIAGSRQIFAFSRDQGLPLSNLLYTIHPRTQTPVNSVCFCAFLSLLLGLLSFAGPVAITAVFTMAVVCQYICFVIPIMARFLGGQKFTHGPFYLGKLSGPVATVASAYMIFMIMVFLFPASPVPNAQTMNYTTVVVGGTMILSSVYYFFPKYGGRYWFHGPVHTIDVDDGVRKDSQNGSGSIEKQNTKSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJH8</accession>
    <name>A0A8H5CJH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Copper radical oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000154">
        <property type="protein sequence ID" value="KAF5342875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJH8"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034503278" description="Copper radical oxidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="458"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5342875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="63743" checksum="02A193C419309ACA" modified="2022-01-19" version="1">MLCPLSALSLLLLYGTGTLAVSVPAVPPVRLKPRAFVSGPWGLTQPGTTGVSAMQLAVTSESTVIILDKVEHNPLTVAGHVAWASELNLNSNKVRPLNPLSNTWCATGSFLGNGTLVSSGGNPIVLNTGRNGIQAIRLFTPCTDGSCDIFEDPNNLHLTSNRWYPSSVRIDDGSVLIYGGSTVGGFQNGAAQNNPTYEFFPPKNINGFNGERIPSQFLKDTLNANHFPIMMLLPDGNIFVAANQQAMLLNWKTNTETRLPNIPNGVRISSPYSAGAVLLPLKPDNNYTPEVMICGGSTVSDQVDPSTLSSQTPASDQCSRMVLNEAGINAGWSVETMPQARIIPELILLPDGRVLIINGAKTGVAGYGNVGDQVGSSNADNPAFSPVLYDPNAAPGKRFSATGISSNIARIYHSTATLTPNGDILVAGSNPNDDVQTRKYATEYRFEYFSPPYMSQPRPSYTGLPATVAYGSTFKLSVQLPDNTSNVSVALIDLGFATHGVHMDHRFVQLESTLSDDGTTLTVTGPPSGTHYPPGPAYLYVVTNDGVPSVGHKTLVGTGNSPPVDAEAMDNMRSSARTHANLDPPAPSPTAGEGSNVADAVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJK7</accession>
    <name>A0A8H5CJK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000153">
        <property type="protein sequence ID" value="KAF5342915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJK7"/>
    <dbReference type="OrthoDB" id="3222453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="686" mass="75047" checksum="7C657E9A3C4D869A" modified="2022-01-19" version="1">MSLQRVDINSPYDMGRVTYQDLYSGQLFTHGHGCALLDPEPHVIGTQSRPELREAYEAGIRIGDVGLIGKSGDFKSIFNIFKPGQDPLNAIFGVPPGFRALPFHENHVSSRDLYYPSNTWVCSKKARSTVLDADGGAVSTLFGPGLGIQFQFSQSQGAALFLPAGARRIDYTAPSTLQAYIEKNAVSWYQFVNDLDLGAYNGSLYLVTGYDRTSCYQNLAFSGSSFQSSLSFKFSSALLPTGNVGVSLCHSSLPSDQRWSGSSGPEHTLNNLSPFIRGFKVMIRPSLIPSLKLLVSVSDLATSETLSRRRQGLPSLPPDEFAAPSRDLEFALATTPSVARDSDLSSYLWSFESDSETESDTPILQTYHPSEVVNAYILDKCSEALVAVTHDNEWSAVLEETDDLFPDKTTLIDRMLRKYPTKFQQDAPMEGISNSTAAELPRHVDGPSDTADEMMMMKLSRGHSQPASDDEDELVQSKRRKLNVLLIDVTPSRAIGIHEQSGSDDYRHLLDMSKSMSSKGSGTSKTKENGPSKVKLSSTKGKGAVKGSSIRAKSGCYTCRIRRKCLGFDTKRPNCLREDNQVSVIREKIKNFLASQGMIKGHSSADPSRVQEEQATILADDAHSDETLSASVQPRGGILILDEEADYTVETESYASAGATTSGAYASSSSMKPVIQKEEQYPWLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK94</accession>
    <name>A0A8H5CK94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000144">
        <property type="protein sequence ID" value="KAF5343279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK94"/>
    <dbReference type="OrthoDB" id="3255824at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="41984" checksum="7B74CE0943E9D269" modified="2022-01-19" version="1">MLAPHSKASVFDVDTTFRNIPIHPSARNFVALMFDGLVYLDQCLNFGKVSSPGIWGHVADAMVHILLNSGIEAFIKWVDDFIFFRYPRLSFGNDLYEYSYNKWLICSVAKELGWPWALSRFVAFAFFFLYIGFHWDIEKKTVELPVAKKLKYSSKISNFLSVVSHMKGEAGSVVCTLKHVTLVVPQGCSYLASPHCFVSGFKDDSQPFTCHHHTKPMVDDLNWWLEQLKLEFLGLHIVNPPPVDESFILFIDASTSWGIGLILNGRWLAWQFKPNWSGNGHHIGWAEMVAIELAILTLVMSHVKNSHICILSDNQGVVGALKAGYSRGPAQNASLRCIISTMQEHSIWLLVVLIPSASNLADDPSQGVFPTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKM6</accession>
    <name>A0A8H5CKM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKM6"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="44465" checksum="9081B17214B658F0" modified="2022-01-19" version="1">MSSLTFSLVGKVAVITGSSRGIGAAVALRLAEEGAKVVVNYVNSASAAEKIVSTIKSKGNGDAIAVKADVGSVEGVVQLLDESVKAFGKIDALVLNAAIMLSNKGLVEVDEPFFDAHMKTNVKGPFFAVKHAVDKGMFPAEGGRVVFFSTSLTMNSAITPNYLVYTMSKGAVEQMARILAKDLASKNITVNTVSPGPIDTDLFRHEKTQELINRIAASSPFNRLGQPEEVAALVAFLVSPGSQWVSGQNIRVNGVYNYTGCYGRNFICGDLPSPVFNRCAPCNHAYCVGYLEEFAAISMNDESLHAAADSLEVPFCLCYLGGCKGTGDNSDGTLYRESKVLLPILPGLDHITCRWTFRRTMVYQLIIRRAETIDNGSNIGQFEDPYGNVLTGGRLGITSTVGSIDPGFWRFAICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKP9</accession>
    <name>A0A8H5CKP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3259294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="207"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5342706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1961" mass="224215" checksum="13ADAE90448EE5AB" modified="2022-01-19" version="1">MISHAIAFDSPVMKVYDILPPPPEDLDEVLAIMFTGPCKPTEKDYKRTPMLVRRKEVFKALNWLRLNHPAYQNITISTDNLNRYPEDIPPVTVAFKMMQSEGNRIPEGTSTHDNELETGTETGSVPFVVHGITGEQLQNTSVELQKAKALAYLKSQGKFLAVGHSEKSSSIFNNPLLYPSIFPWLFPYGMGSIGMTTLKSFSEKNHKKYFMNYHDKRFQTDPLFGFVAFSHEQVKKSTSNGFALTQKKSFSAIADRILNLNPHVLNSLIDKLSKGEIVKPETEEEKLCYQVIQDLDHVGGTVKGSMSSKKFLQVKLWSLISYLGAPSWYITFAPSDQTHPLCLYYAITDENFDINLNLPNDQRTRRIINNPVAGAKFFDFMVQMFIKHILGVNTDHDGIFGKTSGYFGTIEQQGRLTLHLHMLLWITNSMSPQQIRDAILKNEDDFQRKIVEYLESVHCGDFMTGTQEEVQENLQAISENEEYTNPLYSLPQSPPSDCFCTSTEVCERCKAWYKNYQQEVDDIVSRTHIHKCKSTLTKQGTRKAGKDYLGCLDNKFGTCKARFPRETFPSTQVDTETGALRMKKSEAWINTYNQTMTYLLRCNSDVSSLLSGTAIKAVVLYVTEYITKWNLNTHVIFEVIRTILQRNAEMLTGSLPRHEKARKIITQVVNLLSVKMELGAPMIDMYLLDKPDHYTSHEFKSFYWKDFVNEARKFWREPEEVPPNNEEKVVVIRHKGKIVGFSSIFDYIYRPKALNEMTLYKWVCQCEHVKLKAGNKEIDCSDDERSENYDCSSSSDEASDKDTLEVVRPSTQNKARPLQKHRLPKNGHPFMDDHPLASTHYLCMHNKKNIVPNFIGPSLPRKNKGDREFYCSVMLTLFKPWRTGEDLKIKDENWDSAFLNYQFSTHQKFLMDNFELRFECLDSRDDYHAQRKAQSLGIDPSSLEPEFDDGVHFDPFKCSDDSISAREIRRQLDMQEMTDLLVNTGWSNAKCDLKNLIPASFDFPLRSSNVWRLEIAKMKGSVLTNRLKHNKDRPNNFPNKYPNQVEILDQHIFEEKFKSNHTKKLIDDLCIKFQLNQEQERAFRIIANHAVSSISDQLKMYVGGMAGTGKTQVLKTLREFFKERDESHRMIVVAPTGTAAALIQGSTYHSIFGINSSEGEFWKTSLSQICSRLSGVNYVFLDEVSMLSCKDMYKISAKMATALNQPLLPFGGMNMIFAGDFAQLPPAMGGESVSLYSHIIGSNSSDQQASIGKYLWHQVNTVVLLRKNCRQTGKSDQDNKFRQALENMRYKNCTTEDISFLRSLISDPSNDSRSIDNPRFRNTSIILTYNKHKDVANELGSKRFAAETGQVLTPFFSDDEEVVFDEPPTKTCDRKRKRRKATKHQIDEHVQQLLWKQAPSTNNMQIPSILHLCKGLPVMIRFNGATELCITKGQEGTVHGWQARKGKRGQLVLDVLYVKLEKPPTNIQFKDLPLNVVPITPNTRRINCKLPDDRIIQISRTQVEILPNFAMTDFASQGKTRDPNVADIYNSRDFRAIYTALSRSSSASGTMILQGFNVSHITGGISNKGGYRQELRELEILNDITKLRVDQKLPRSIIGELRGPLIQQYRSHFGNRHRPEGLHQSLVWDADEKFESTLHKDISWIILEKEETKHHAKKKQSGNFVPIDMTSLDCNEMKDKSISILSEETSVSEQAPSHDYPTLKWSANSCAYDSALMLLYHLFRTERAAFLGESDNFSSILMNELSATFQSNSSNYADIRDQIRRQLSIIDPDAFPDGAYADTSDVLHELMWSVNPTTKRTVFCGNNHFSLRERMQHNLLLTRTTGTYQSTQACVSHFVEPWADQCPSCHSDMLRKYTFQRFPKFFLMSIPYECNMQIQNIIHVPQGAESKQYHINGIIYFGNDHFITRMFDGAHEWVYDGIGTGIATKLSPDVQANNDALEFFAHKKAVVVLYVCSENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM53</accession>
    <name>A0A8H5CM53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">factor independent urate hydroxylase</fullName>
            <ecNumber evidence="4">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_013255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM53"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034457740" description="factor independent urate hydroxylase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5344361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="42528" checksum="BC02AFCC379ED61E" modified="2022-01-19" version="1">MLPIWNANSSRLTLTLFHPLLSLAPSSSNSKTFPTSPNVTTTTTTTTTMSSDPTTLSYLSHARYGKDKIRLLRVVRKGAWHHVVEYNVQVLLEGSISTSYTQADNSVVVATDSMKNITYYLAKVSPHVLIPERFALHLGTHLVSKYAHIDKAYVEIEQLRWSRIPVSDGDGKDGKEQVKEHPHSFWRDGEEKRVVEVEVDASKGKDTLIAKVTSGLKDLLILKSTGSAFTNFIRDEYTTLVEVDDRIFSTSVDLSYTFNSFSISPPTDEKKLEFAIPESGPDSELPIGGVWDTEVPKRAREVTLETFAKDDSASVQATLYKMAQKIIADNAGVQEVSYSLPNKHYVPVDMKYIGVDNMTPKEAEVFIPLAAPSGLISATVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMH2</accession>
    <name>A0A8H5CMH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMH2"/>
    <dbReference type="OrthoDB" id="3174341at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="43232" checksum="4E01737AD59F7ED3" modified="2022-01-19" version="1">MADSDPEQSVLTSQDSWDISEAVISETIQGLFYGLECLLMFAAVYKLSRRGLRKSIRRQLLILVIAIMFICSTTTAVCNVVGDVVQLRSMAPALNYDPTMAIQKTQIIAVFTTRISYLLGDLIVVWRAWILFGGEPIFRGVLAACFTMTFVAAIVNLVFTIRNILDFEFKPQPGARLILPATLFFTNMVATSFIAYKTWYYRRSVAKFLNRGSKRGQVENVLILLIESGFLYSFLWILSLISTSNPQYYDFAVFFGTILPHAAGIYPTTIILLTAFQKSCCDTTLQGQVPSLGVHTTKSSDREERGVPTQSLRFAPMQATRTGDEDFRSSSDFGRSASRGRYSRENRMDSEVEMYGIDIVEAGHKRDSVSRGSKHEGIKHEGTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNF2</accession>
    <name>A0A8H5CNF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_008867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNF2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5344078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="66759" checksum="E4A8427E3C18A564" modified="2022-01-19" version="1">MANKRQVALTPSSSYGAPTINTRVPMFLQKLYKIVSDPATNDVICWSDSGDSFFVHDHERLAKEHLGNWFKHNKFASFVRQLNMYGFHKIPHLQQGVLKSDSDAEHSQFAHPDFHRGQEDRLIFIERKKQTGSAREQGVIDFPSSSQPNPAQNSLPPNQALDIHSIVSGIAAIRRHQNSISAELNELKRSNQILWQESMEARNRYQKQQDTINRIVKFLAGVFGHHTNSSPRDSKQGDSPSHSVVPGARLMIEDTKRDSGPKVGIVEVRDEDNVSPVEVFSRETSPFVTVETPADTTVSRATSRPPSDAPSPLMSSFTVNTPGHDGTPRQDYPTSPTETATSNNNSIISTQPRYSTSGMLNDSNLPFSPSHSPIADERIQEALNKLSPGDLQQFIASLSQMPGPDINPDINGDGSGNAQISHLSPAQLTPYKGSFDFGSYSHEPSPGNIDQFSDNLISFDTPTSLEQSWKASGDIDKEVNTLNAGIDSLMETLGLDPSAFLDVEGMGDGTNLSEDPAALLDTSLTTGNGLVHPPPNSDEIFNSFMNTFSTDMTNAPGPPTASDGPPSPFTVQTPDAEAQMAGRSRKRKSDAGLDPLKLHIPSNKAKKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNT7</accession>
    <name>A0A8H5CNT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNT7"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033986408" description="Cupredoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="39871" checksum="8A8B409222BCFC64" modified="2022-01-19" version="1">MLSSTTRTLILAASALSLATAAFATNYDVAVGPNGNLVFYPEYVIAQPGDTVNFVFHPKNHTVTQSSFDSPCSPADGGINSGFMPVAPGSEGGPLPNWSVTVNDTNPVWIYCQQTMPKPHCGQGMVFAINPPPADSDKSFEAFKDKAVGTSGESTVEAVTSTPPPQTWAEATATVSSSGSVWVSTYTSYEGTPEPTYAPQPVTHTIIVGDSGQLMYNPMNISASLGDTVIFEFHQKNHTVTQSNFNTPCTPKDGGFTSGFRPVAPDVTSNFPTFQITINDTAPIWGYCQQTQPASHCGAGMVFSINAVETGVNNFAAFQALAIEQAGPGSSGATGGNSSSSGNGNGGSGSGNGDSSSGGNGGNNGAVSISMNKGSLVLGFVGVIMAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPF1</accession>
    <name>A0A8H5CPF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPF1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="38194" checksum="2AD7BF7ACB4A046B" modified="2022-01-19" version="1">MDSEAKTMTAVLTTGSGGIELRRIAVPQPGPEQVLVKVIVAAQNPTDWKTVINFKRKGNVVGCEFAGVVALVGENVKAEEVQVGQRVTGCVHGSIKPNGAFAEYLVAPSHLLIKLPDHLSFEQAAQVTIASTTAYCCLYQALSLPLPSDSTTPVTGSLLIWGGNTSVGRLTIQLAKMSGLQRIISTSSPQNFDSLRKLGATDVFDYRDPLAGEKIHLCTSGSLCMAVDCISEGTTPYQVSTALSAAGGTIATVNPYVSRKNGIETILTLVYTMLGNAFEFPIVYEPDPRQVEIGKRICQTVAVLLAGQQIQLGPVKIIPRGLVGVAEGFEFMKRGAVTGEKIVYRIADTPALDFIDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPR9</accession>
    <name>A0A8H5CPR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPR9"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="193" mass="21358" checksum="52F252CE4D74B3D8" modified="2022-01-19" version="1">MGSTVDANKSSYGSGLLQFTQFCDEHEIPEEAQLPADQVILTAFIGWECGKVLGKTVSQHLSGLLAWHNIHGMPWAGEDSWVKMGRATAHKEGTEHQRDPQVPVSQEHLFALAEDLDETKSKDAAVLACAMSTTWAVRRLGKTTVHSAKKFSEISRFERCEYSGHREGRCLCSGNTFTLDKDNKATGRKDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQF5</accession>
    <name>A0A8H5CQF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenosine kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_009714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 12"/>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQF5"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1110.10:FF:000001">
        <property type="entry name" value="Adenosine kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5345196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="36658" checksum="F38ED560EE7506E5" modified="2022-01-19" version="1">MSTYSLFCMGNPLLDMQVRDGEALLQKYDLKANDAILAEEKHAPIYDELVKNYEVTYVAGGASQNAARGAAYILPPKSVVYTGCVGDDSLAEQLKAANKREGLDEVYQVKKGEKTGACAVVITGHHRSLVTTLRVAEKFDKSHLSSPEVAPLIEGAKAFYVEGYFLTHGTESALEVSQKASTASKVFALNFSAPFIPQFFGTQLGQILSHTDIVIANEAEAEAWANANGLSNPTDLPAVAKAIALKPKSNASRSRIVVITHGAESTVVVNGAEPDAPKIYPVHALTDDQIVDTNGAGDAFAGGFMGAWVAGKSLDECVEAGHKMGSMCVQQVGPQFKWPKVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQU7</accession>
    <name>A0A8H5CQU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQU7"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5345933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="65" mass="7732" checksum="4CFDBE42EBF660DF" modified="2022-01-19" version="1">MVIIGDKWNVYLELLGKDMSEGDALDELQLKRYCCRRMVLTHVDLIEKLLQYNPMERSKEKPQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSA5</accession>
    <name>A0A8H5CSA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSA5"/>
    <dbReference type="OrthoDB" id="2905774at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034570046" description="F-box domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="680" mass="77062" checksum="5EE6FA71FB226323" modified="2022-01-19" version="1">MPFLSAILNAFGFGRAQSVASDSSDSSDEEESHNYPISNGIPLCTRCNAHFELPAAIRGTSCTSMLSERLRAGYVPTDLEAAQIPSCVQSLSHEVDRLDVQLAWIDQVRGQLHGCRNVFHRMAEEHQGLLAPIRKLPVETLSMIFSYHSYPYGLSINMAAPKRRISPITLDLAQTCSRWRQVVFSQPALWSRLFIDLNHPSPNIDDLVHYYLRHSANAPLVLWIEAIEPDRWSTIPGRWSLAPILSRKGWYILEMLMKEGHRWKHVTFRLECFIFHTEAFTNRRYSLAKHDYFPILESIQLAMTGDPMAMSDEDECSAFYRTIVCDAPKLHWLTTNHLHGSLFGVLQFDQLTHITLEVPSERLRSDVPRLLKLCPRLEGLVLNEGPDVLQSHESFGTLSIWDRWNHDRLKSLVIKVDLESKDSLNDASFLLCNLELPSIASLKLVGKGLKIDPFLQAYFCESLEAFLVRSSSSTLKELSIFGAVFLTGKQLVQILTLTPSLEYFLLSSSSEIRPYSLFKALTFPKPLLLSPSSSSSKSRKGKGKARQSTSLSSSTTKAVLLPHLKNLTIRLIEAWGSKPKIPNPDVMISMVESRRWNSVRGIGMGIGAFPTCMEDQPLLDELKYFELDLDQIYTQKYGLSPEWFQNFRSAAEPRLRELASMGLELRIELPTYTYEHPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUL1</accession>
    <name>A0A8H5CUL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUL1"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39012" checksum="83D36D4444F24FF5" modified="2022-01-19" version="1">MLKENCSSTLSTVSSSSITSHQNIHCATLLLRRVTMSSDHFNYAKNIGHYSSVAAAIAFALVYVLLFIRFIPPLIRQRSSVLLMMVLFCLNKSIFPFGSVYRRSDHYDHLAVRIGSFALRAVLASSDSAGENEGLFIADQILLSAGFIGLLYSTYGLGLDQHLPLFIAMNNYPTISIDLVLDRSSTREVLQAMLHAILFHRLFGTVKPKTFEVLDVTMPGVSDPDMEKLVDEKVDAFWKGIERGVSKRGQVMVTFSERKAKKGWFQMHMGEEDVPWEQWVINAEVRQPRDGDRQVFDTKLAATLTKSIQTMLTHTSSDRGRAVVPPITNASGISPFPFKISVQVGDQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW40</accession>
    <name>A0A8H5CW40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000087">
        <property type="protein sequence ID" value="KAF5348181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW40"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Berberine/berberine-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="8287" checksum="CA84A1E5B9E0D8FB" modified="2022-01-19" version="1">MGYFQGALKDLSKVIQDRAIEEGESKADDLRYPNYALEGTPLELMYGESLPRLREIRAAVDPENVMGLTGGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXG3</accession>
    <name>A0A8H5CXG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXG3"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5349821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="184" mass="20591" checksum="4C520A1233404BE6" modified="2022-01-19" version="1">MVVLKFQRGLRPALEKKVAEAEACPQEWDVMAWYSLAKRFDKHEREDAIFCSAQRSVPPGLPKPSFPSRTQPQGRSLFPIQFPVPAPAPASRAPAPAQAPLPQGIPMEVDASRQRFLACHTCYTCGKTGHFSAVCPDHQCEHVRVMDMSIDDWQEITEAYAAFQDFQAAPTNESTQEDFAKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D073</accession>
    <name>A0A8H5D073_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D073"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="32288" checksum="9AACA88423E86440" modified="2022-01-19" version="1">MNVGQSHQDHEHIQRQYPVCIVGAGPTGLAAAHALEAKNYSVVVFDKQPEVGGKSQAYNDGDQGSLFHAMGALLISNASYIDTLPIVEAAGVPFLPALSVTSGWIYPPVLANTSVINVTRTPNPSPAQINLIESEFSRYTDLRSKIFEPYGAMRYTNGIPGDLTIPIGQWLSQNGFQVLPIVINAGLSLAGYGDIEHTPTIYALQYLSPDILAFFANLGPVNFVDFHAVMSHYASSIRGRIHTNTAVTKIDRSGPVPVLTYVSRNTESTRLQTQTQKCSHLILAFPPLLEALRSSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1Z7</accession>
    <name>A0A8H5D1Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1Z7"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="41"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5352020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="43862" checksum="2CC6767EA17BAE1E" modified="2022-01-19" version="1">MLKKPLVFGPSLTGLLNKTAQMGATLSPEYIDISTRPTAFSNPPRKLLVLDLNGSLLLRTKHVQRNHSNMRTVHPRPYMRSFRDYLFHARVKEWLDTVVWSSAQPHSVADMVDKCFGDRKADFKAIWARDTLGLNKYQYSQKSQTTKDLKKIWSAFPSHSAYTTVLLDDSPRKARQQPWNHLCIHEYDSKMRLKDVEVWKCVNSSSKSSKNALKKGAKKEKKRQKKLVEGGVEATSIPPPTEPSCPHEEKPAEHSAILDLDHNTSYDQTLLAIIGILEALKSQNNVASWIRAGGLSRVEPVPIPKLSSLQLLRSVNSDPDVVAEDEEGKEVNVNEEDEGGAREDRNSETKLLDAHDTWFEHLEMVSAWANRGKAALDRLEIEVDPGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D207</accession>
    <name>A0A8H5D207_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EML-like second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="450"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="493"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="588"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="665"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="794"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="837"/>
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        </location>
    </feature>
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            <begin position="880"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="923"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="966"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116231" checksum="CAEB457BFD0E34AC" modified="2022-01-19" version="1">MSGKLFIYAATIVKFILEPGNSFMAEKRMNRVLDLKYKPEKHQTKGLDELYDTILDNSFENLLSEEKDNHLSIIHTVITVCRPVSLSVISKMLNLELEEVQLVIMKLYSVLYVADSDQAIYTLHASFPDYILAKERAKEAFWCNQEFYHTMLSKACFMNMMENLKFNMGEIPTSCLLDKDIPDRKKNIDETLAYSCTYWPYHLWGSSLEKDIVEAWERFMKERSIFWIEAVNLLTSIPEAYDGLQFLLETTKNREYEAEIQAEILKLQEFLAFHAKSPGVERTPHLYLSSLPFWQKHFLGKQILQRSINLEKCFQQSREMECWPTSSVVIAVAISKDGKLIVSGHGDGTITIWNVLRGKEVRKINAHSDKVYSVGFSPDGTKIVSGSADKTVRIWDAATGAQIGEPLQCHSDSIQSVAFSPDRTKIVSGSNDKTVRIWNAATGAQIGEPLQGHSDWIRSVAFSPDGTKIVSGSDDKTVRIRDAATGAQIGEPLQGHSKWILAVAFSHDGTKIVSGSADKTVRIWDAATGTQIGEPLQGHSGYIRSVAFSPDGTKIVSGSNDKTVRIWDAATGTQIGEPLQGHSNWIRSVAFSPDGTKIVSGSNDKTVRIWDADTGAQIGEPLQGHSNWIRSVAFSPDGTNIVSGSDDKTIRIWHAATGTQIGEPLQGHSDWIRSVAFSPDGTKIASGSNDKTVRIWDADTGAQIGEPLQGHSNWILSVAFSPDGTKIVSGSYDKTVRIWDADTGAQIGEPLQGHSNWILSVAFSPDGTKIVSGSYDKTVRIWDADTGAQIGEPLQGHRNWISSVAFLPDGTKIVSGSNDKTVRIWDAATGAQIGEPFQGHSDCITSVAFSPDGTKIVSGSYDKTVRIWDAAAGAQIGEPLQGHNNWILSVAFSPDGTKIVSGSNDETIRIWDADTGAQIGEPSQGHSDCINSVAFSPDGTKIVSASDDKTVRIWDAATRAQIGESLAGHSGLVWSVAFSPDGGRIASGSGNSTIRVWEVPADNTGLVTQRDINMLWSVDNDGWVHFSNISPGIVWIPPQFHPLLWRPQNTHYFQTRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D672</accession>
    <name>A0A8H5D672_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D672"/>
    <dbReference type="OrthoDB" id="3178264at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="73"/>
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        </location>
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            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="37217" checksum="FB3799C323F2CA13" modified="2022-01-19" version="1">MVAAGKNLELLSDYRHKETIPKLESFSQRSFTPLHFWLSRPGVLSALFSSFSFRFIAGAVLCLLLFFQSLSSLNTMVFLRPAFIAALISTSIFRSCCYAARFKAVTGLTATKKAMDKMSLLATQDAAAAASPISDVNTSLQSAQDGQAIAAEAGTKVSDGFQAVKAALDSIKATNSSSPFGYALRQVITQIEDAIKAGTEVGTSCGGGGAGSSASASASNMASASNTIAQSSIASSVASTSASTKNNASASTSASGSASASTFASASSSASATAQASATDKSANSASDTTSVKVTSTGSSSGSGSGSGSNTITVTETVTVTSKGASQATSSNAASASQANSSKASGATSSASASQAASSSGLDATSAASGSHASQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCR0</accession>
    <name>A0A8H5FCR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000315">
        <property type="protein sequence ID" value="KAF5332039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCR0"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5332039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="16788" checksum="68623A0C5D39AA49" modified="2022-01-19" version="1">MHLSTGLVYSAIGDTGVHYAFYRPHSPTSSTTPSGVVTTQDASPPPVEDSVDYQGNLQAIQNLMGLHADTHASITPILSQLSLFSPASTTVLTILALLIPSILFLSPFIPTRLIAFFAVALPVLSSNPYYSFNFTITSLPAFVPIISGHGPPHQHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDX0</accession>
    <name>A0A8H5FDX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000299">
        <property type="protein sequence ID" value="KAF5332923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDX0"/>
    <dbReference type="OrthoDB" id="3265564at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034889910" evidence="3">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5332923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="306" mass="30157" checksum="08E2D3007D241399" modified="2022-01-19" version="1">MRFSSTFAILAAVVTASYAAVIPSIQGAPSPHGLSLARLPRHYINSGGPGSDSPATADSSANADVSPACADPGNSTASVNANTNAVSSGGSANAGVSPASNAGSGNPSTSVNADTNAVSSASTGSAPAACACHTIPDIISDVTSKISPLVAQLKNLNTPGACTVAQVTPIINQIKPILSGAIDQVKAISSNNVSGDAAMISSTAGGILSSLQLCTLIATLFKMIFGVFGVLMKVVVDAESKGVCALFSDVSLLLATLLQLIFGVVSGLGGILKVLLSVVAPVMSELHTDGVFNSILGGYGGSLTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF67</accession>
    <name>A0A8H5FF67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF67"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="316"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="758" mass="85875" checksum="5CD8373E8BCA3813" modified="2022-01-19" version="1">MAKRGPKRGTLWTTAFQPVDVLVKQILDETSSRPFTIPDSKESVRKMFVKLAKRIQELEKDRQFDNHDNSTFELRDNLDASNFMPSTPADTDTRSDNGEETESNIEDLSEELSKFAFGRERGTHFGESSNVMLMKVALEHNKELHGPSGPDWNSILAHIRRPDFWEIDPVSEATFSYSNAEYNASAKGPSYLISQHDLDAPIYNFPTTDDLHRFIDIYFTEWETYQPLLHRPWFEKSIRGGLHHCDSAFGAVVLAVCAHGAKLLSRSRQEDPGDCWFRQIRLHSFVFKEDLELYHLQLYCLMMTYFFGVGKGIDNAWVLAGIAIRRAQEKGAHRRHTSSSQHPTVEGELWKRAFWMLILLDTMMSAYYGRPRAMSVQDFDLDPLIECDDEYWEPEDGSQAFVQPAGKPSKIAYWNAYMRLVEIYGFALLNIYSVRKNVLGSKIGIGNREWYEKAMMAIDSAMNEWMGLVPEHLQWDNQHDDPVFFTQSTLLSSWYSWIQIAVHRRFIPRPRDRSTLSLPSLAICISAARSSLRVCERFTKRLGNYHPQLILKIRIDPRKEMMDIYKFIDLLRFYERASIGLANTSGSIANSPKQPRTAQSQAATLSLPSLPLSSSNEISIQPSSVYPSIGPESIQPLSSGSPTSYSTPNPPLLLHSSEVGGLPIPDSLNSVPFASFEGPSAEASISSSISPDMQQYFSLFDECTMGNTNLTDHNFGDTSQNRPSTTQDWDSFMASVDQLLGIANIPSAGTQSFDPFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FH40</accession>
    <name>A0A8H5FH40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000231">
        <property type="protein sequence ID" value="KAF5336208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FH40"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="708"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5336208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="844" mass="93129" checksum="7C6A1819AF884D3F" modified="2022-01-19" version="1">MQKWINAPDSSVNFNAAYDKMTEGTGEWLLNDSRLIQWKESGGLLWLQGKAGSGKTFLLTKAITSLKADNHDVLYFYFDTRDQSKAKATYKGMLASLMLDMGIQFNQAQLMYLYETYSSGRTQMPADAMRSTLLDFLRQKSSSMFIFVDAFDECDNQEQHPVTEFIQQLLVQGLKIHICVSCRYPANHIGMNAGTYEISLNPEVVEGDIEIYIQQSLQSRPLFVNIKEEVTEALLHGSHGQIRWVDCQIQYFHQLGSGRAIRKALKSLPKTLEETYEQALSAIKREHKDDAQAILKWLLFGYDELTMKMLPEIFRIDFEQQSLDDPEPIQGHELCNIISSTLVVVQQVTRWNHQTHQFDQQEDILQLGHSSVKEYIVSEEIKESSAKLFQINDQLAHEFIAQCCLIYLVVCGSDGHIDWELSPLANYAVKGWTEHVRNLQPLGDPVKCLSLHLLTDTNTSCLTWMHSRHYLWGAAAGSALPFYYASMVNLPNMISSMIENGADVNAQGGEYGNALQAASYRREVDIVKLLLENGADVNAQGGVYGNALQAASWRGSVDIVKLLLENGADVNAQGGVYSNALQAASWRGSVDIVKLLLENGADVNAQGGKDGNALQAASWKGNVDIVKLLLENGADVNAQGGVYGNALQAASFRGEVDIVKLLLENGADVNAQGGAYGNALHAASFRGEVDIVKLLLENGADVNAQGGEYGNALQGASYRGAVDIVKFLLEKGANVNVKGGKYGTALQAASIAAIDWDPHCDYVKLVEILLDNGADINSCGQYGSPIQAAAIEGNQEIYDLLIQKGATPIDPLFTIFQKDPKIPFPLMDNEPADHQIYCPLFWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FID7</accession>
    <name>A0A8H5FID7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000215">
        <property type="protein sequence ID" value="KAF5337543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FID7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="12851" checksum="DB97DC6EE95ED245" modified="2022-01-19" version="1">MPFLPAFSLSLAIHLSSHLPNNLTSTHLSTNASEHRVPSKPTLSLPQLHYELKFERYFSPFLRFCIGTGSMGLWAAPVRGVDPLAQNMLDLDLGLRLMGTDDGETSMRRSQRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKI7</accession>
    <name>A0A8H5FKI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKI7"/>
    <dbReference type="OrthoDB" id="3223377at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="165"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="463" mass="49649" checksum="3C0493448A7258A4" modified="2022-01-19" version="1">MAGSVPAVGAGPVVIAYLLAILSFGMLVAQTYLYFSAFPNDRNWIKTLVYSLFALCTLQAIFSIHDMSIYFGSEYGNVEVFMKIMLGGYTLPIVTGIVSCAVQVFYAYQIYVISRSKIWAGLIVTLALVQMGASCFETAIDIRVKSFKTLRREGYIVASVWLVGSALCDLIIAVLMTIYLLRADSGHSMLGSTSSPLRRLKSLIVQTGTASAAFGITGCILFLTRSDTSFQIPIKPLGNIYVSSLLVILNNRMRIVGSQLEIRPEDLSLHIEMSHAVAHAHTHIGFGGGGGGDFNVHPHAHTQSLSLASRMEGISGSISRPSSVVRSSLSRGRSHGPTTGRTGTGTAVGAGVGARAGSVRSSRDREVFTITTITTPRLSPSNTSRDDLDLESQCHRDWTTKCSCTSISSPTQKYQGRGKDIRRCLETQAHRGTAARPLKALETPQTSGGLKLVSLATAANVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPS4</accession>
    <name>A0A8H5FPS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPS4"/>
    <dbReference type="OrthoDB" id="2917041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="396" mass="45280" checksum="8A555EB6E5CA55BA" modified="2022-01-19" version="1">MQCWTSSELMIDWLINHFDPQTREKAQGRHRALFMDGHSFHFMEPVIAFALENDIVIIGYPPHCTHALQGLDIVCFAKFKAQLKKAVVNFEEQHGQAVSKADFMGVFGTAFNELFDSDTIRAAWKATGLHPFDPSVIKPEQMKPAEAHSSIPLPLLIAKEKECMEEPNWNLINMSSDPVQYTRKEPMGRQIGQLTIALSEAKTLVDVHRENEEAWAAQAVLQDLQLKKMKRVIVAQEERKKDKGDKDNTSLPGPSEGYGRIWSAEDILELKRKKWEGEEQEAREKKERVKNKEDMKIKKAAFEAEWKKIIEGHKRAVDKWNEECRQLKENGAKKKDWPRKPTHISKKDLSVKWFGTSKKSSQEVVGDDKGATGGEGDKESNKEDEPVDVQNDFDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQJ1</accession>
    <name>A0A8H5FQJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQJ1"/>
    <dbReference type="OrthoDB" id="3246760at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="279" mass="31746" checksum="3F0768D0E119DB64" modified="2022-01-19" version="1">MDAGEALEDLYFSDSDSSESDSSSSDTDASWDTSSTSLSDLSEEEPTPVQKFVQRMTTLYSRRNLEPHKTIPKSQTLCILLDDYRHNRPELFCEYLHIDPYCFDNLVSVFNNNSNNPQMPVEEQLVITLYCFGHYGNTASYNKVALLFGVGHGTVPLCTSRVLKAVNSERFQNVSVQWPNKQQWVQDNSCESWCDGWLIVDGTLIPLYHRPSYFGNVYYDRKSNYSVNVQLVSTPNLDIINYSVGLPGSQHNATAWKETHTHRDHLMILPLVKVADTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQK7</accession>
    <name>A0A8H5FQK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQK7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="236" mass="25507" checksum="8DAAC36791C107D1" modified="2022-01-19" version="1">MSSTMSAATGTAHQNSPDRISVTEQRVDPPNVSSMSGPAPTASETSPDATDDLERTVSSVHTTSIHAVVTQTQTQSVSLQILNHSSNSHISHCVLSNVGGDATTTNNHYHFNISGPTTLQCHSDHIHPVVDVAADNVEQDPESAQCRLVKRAQPEGIPPELKHPQAQAPEGLLRRRSVVEAHGNAERIGEETPSVADWIDHLVHAQATNSRWPRRVAVNMRQVAVALISEVPEQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTQ2</accession>
    <name>A0A8H5FTQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000081">
        <property type="protein sequence ID" value="KAF5349375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTQ2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="14225" checksum="B8562B7401CCF8B5" modified="2022-01-19" version="1">METTDGNFELQYALSSTKTALDSQWTTQIRLSMSWNRLKTTDGNFELQYASRRQKQPFPMDDSDSSVDVMEQAEKLPMDDPDLSVDVVEQAENFSFMQSSSGALVLYYDNSSQTQISMPRGERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWP9</accession>
    <name>A0A8H5FWP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWP9"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26520" checksum="CB71AC085A93722B" modified="2022-01-19" version="1">MAPSKTNKTASAATRTKKEKIFHPQSRKADQLARKSLRKDKLSAQSSDRKQKHNNLADFYGFFYHSLPSEGVLSLEDLHSLIANIWLKRFDEDLEAERASRRKGRPKSTREQKLEELQLRESEQYRTGLEVIDLTHPPTVALFRTWNQIEVAFIDLLRFIRINSTNPKNVVVSKAGKHITIVGEESESIEGKDVEMEMDPQSHVSSGVSTPSILKEPPSRFGSTIMTMDEQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FY82</accession>
    <name>A0A8H5FY82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FY82"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="14924" checksum="C780142F07D34805" modified="2022-01-19" version="1">MRMIERGGMRMERLILDTNNMDTGYKEGGQKSQMKCLTLHIRIIYTLTRTRNRWPYRHSPRDDAWSPCHSFFVAHEEANNVTVSIRPPSYPFPSAEYWMFCHTCNTSQSSFTGVSPGQDARIPYWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYT0</accession>
    <name>A0A8H5FYT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYT0"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="42901" checksum="5FE0B5BDE0102D40" modified="2022-01-19" version="1">MSTSKLFQPLKVGDITLKHRVALAPLTRFRADEKHVPLPIVKEMYAQRASTPGTLLITEATVIDARAGGYPHVPGIWSEEQIAAWKEVTSAVHAKGSFIYLQLWAIGRTAYSAVLKAENPSYDLVSASDIPLSDHSKDEPRPRPLTVPEIKEYIELFAKAASNAVHKAGFDGVEIHNANGYLLDQFMQDVSNHRTDEYGGSVENRARFTLEVVDAVVKAVGPRKTGIRFSPWNPFQDMGMDNVSKTKAQFSYVVSKIKEAHPTFSYVHVLEPRLKGLDVLDHNPEGEDNDFIREIWTSPEDDQNGRRFISAGGYTRELSLENAEKTGDIIAFGRVFIANPDLPYRLKHDIPLNDYDRTTFYVQNSVDPKGYTDYPFVEGNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G124</accession>
    <name>A0A8H5G124_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G124"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034986848" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5356372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="21127" checksum="4E087DEE1EFD4219" modified="2022-01-19" version="1">MIPAKALIILAVSYSAAAAALDKRAHVVSCADPTNNELITQEFGNAMNMASIASQYIAQNGADPLFVSYFMTNDPVAVKTKYDQIVSDVGPADIYCQPFPAGRNVNCSGLNALTRTPSGNIYLCPSWYNLADQSALCTQSGLASTRSGTIVHEMSHAEAGTHDHNGSCSGSKTLSPADALENATTYSCFAREVYKKTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2Y0</accession>
    <name>A0A8H5G2Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2Y0"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5357386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="162" mass="17958" checksum="969D2F93D814D0C1" modified="2022-01-19" version="1">MIVPINFNPTSSPKLPSTLAKISHDEVVLIELQGQLELENPSQRNGMLVGTLKIDEELKKPTLHIGPHLIEGKLANLSKPLAVLRRSQLSPTTSIIPPKIPVDEDSMDVDDRTEGDAAQSTLKYDIDEALLEEKEISWDAIAIVKRKIVFSKRPMPMVGKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2Y6</accession>
    <name>A0A8H5G2Y6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 78 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2Y6"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="409"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="739"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="88192" checksum="8489FB67FBA9BEB5" modified="2022-01-19" version="1">MSFVPLVCRRASFSPLSLRPSPLFSRCTYALLTPRSSQRYFFVSPAKLQKVQDGKIDAPATSTTTTEASPKDVYHGPLTASFRRLKLVSLSSLSLSLFCSPFFFIVESNLPGFARAALAATAVGTSGLSTALVSWATRPYVTTLRRLDPTTDGVKGLEMTTLTLTLQPRITRVYDLDFLVDTQRPLAKWELAREVILPAQTDKALPIAGQEETVAETMDKNGKILGSWVATLTGDGSYVVLDWGKEVGGRVSLTVNNASTDSALSLSFTESSQFISPTLSDDSCFATASLAGDGVQSLPSPLTEGLFTQGIGQQRGGFRYLTIVSNNDSPVTISNISLEITFMPQMDDLRAYTGYFSAQDPGFHDPDFLTKIWYAGSYTVQTNTIDSHQARQQPCWANNATGGPVEGTILVDGAKRDRNVWPGDMGISTFTEAVSTSDLESSKNSLLVMFSTQDPATGALQYSGPPINAQGSDTYISWSLIGTHTVWFYTGDIDFVKDVWTNYTKALAFLQSQVDDTGLVNVPAAFANDWGRDGGGGHNSAANTLTTAAELAAELGDSDLAAEYAANASSVKDAFNALLWDDTAGMYRDNDATGLHPQDGNSLAILFNITETEDQIQSISEGLTAFWTDIGPLSPELNDTIIPFIGGFELQAHFIAGQGERALDLLHREWGYMLYTNLSVQSTLLEGFTANGSLGYRSAAGYDFDHSYTSHAHGWACGPTFALTAHVAGLQITSPLGATWSVAPVLSGLSAAEGGFETPLGWFGVKWNVDDEGVLNVTVDTPSGTNGTALLPGQGPISVNGETNQVDGPVTLAGGSHTISRKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3L4</accession>
    <name>A0A8H5G3L4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3L4"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="34970" checksum="99CE6FA03B0F6FEF" modified="2022-01-19" version="1">MGGFVTRQGHHPIILPSQLTEEILLDIKATKVQDIKDKSKGDAVSKGVTLLQTSWFLVQILTRAIQHLPIAALEISTVAFAVLNLLVYGLWWYKPLDVQRSIMIGPGPEEIEISATSYRQWFSPARILKFLKFVVFGGSNYYPEKSISVPIIWAGYPEESISVIWAGYSYQFEGAGFMMTSVVASIVACLFGAIHCVAWNFSFPTSTEQTMWRISAAFVALFPSLFSPGLATRCIQDGLYWESLLKRFRFLRYIELFPQWIYIAIIVTGLPLYVVCRLVLLTITFTTLRSLPADAYRDIDWTRYLPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G622</accession>
    <name>A0A8H5G622_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G622"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="378"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="451"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5358997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71343" checksum="CEE7383EDC2BCDF4" modified="2022-01-19" version="1">MARTNIAKKKSKVIKLRDEEDQILGESSESETEMPEFDANKNWEFDIVGEEITGRKETLRYELNWPDWDGWPDGGTNTWLTREEAKAELGEDPLKNWNDRMAVKRKSLARQSAVIDDVWWAQMDILSEPDYHRSQAVPERLKHRKKKALDLDSKMERLLAKHEGRSPPQTPGRSLRAETVESDVRRSSRRGESILSTASTLRSTSSFTSFSQIHQLSTPSTSGSGSKRALSSVTNSPPTKYASVVDVLNSRASSSTMSTRSYRTQSSSRSSVSSLTTPPTSIASYSSSSSKGKERTPVVEVPMLPRKRSLTSRPPSKQKALGDKWTAIARKEGAASITFVNTVDHEELPSLSRHFVYQESNYNYSDKAITVFDSALIVGCECIECVAAHQCSCQGESEILDDTQTYRVFAYDEEGLFRFNVPEGTEVIECNQSCSCSIDCPNRVAQRPRRFPLEIFKTENYGWGVRSTVHIEKGRVLGHYSGKVIPRERADQLDREEGMYCFNIDGREDPEAAIADAYSVDARECGNWTRFLKYISRSPYCDRLLIVRLAKSHSCSPNIKVYLAVWDTIPENKMPNIVFAALEDIPARTEFTFDYDPSAPNPNKSKKGKGKAQIPEGARPCFCETAECRGYVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G806</accession>
    <name>A0A8H5G806_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G806"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="117" mass="13207" checksum="BB3BEBD778C04457" modified="2022-01-19" version="1">MPSLIHNSELDLSLALLTKKEEQKSLDNVSPDPASYGLHFDDSNFKILVKADSAAPGVDRKDYLRKLETCVSLFKQDAQEEPDLLIIGVPWAPFCFHWLENPSYASTDTKHRYIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAE4</accession>
    <name>A0A8H5GAE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAE4"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5361150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="458" mass="51430" checksum="5A5211FC02B09B79" modified="2022-01-19" version="1">MSSGSRLRVAICGAGIAGLTCALALSEYPDIEIDVFESAGKLAEVGAGIGLFPRPWQIIRRLGLEQDLLKTTESRLLEGRVPSFRYRKSDQREGVEFFRLYTQGALIFLHRADYQQTLLHHLPKSCRTHCSKRLLSYRQSHNRHGVDLFFEDGTSYSCDVLIGADGLKSAVRRCMLHEKSGIAQAEGKWEESMELLRSVDPIWSGQNAYRALIPAEKLRARAPSHSVFTAPMQYLGKNGYVISYPISGGKMINFVAFDMRHELENTKFNGPWVSTSNKSRFASRFADWEPEVQTLMECVEEPLQWAIHTIPPMKSFISGRVTVMGDAAHAMTPHEGSGAGQAIEDAYLLATVLGHPRTNSTNVHRALSVYDSIRRPLAYDVMEHSRMNGRYFSLNIDGVDFDSNRVGPREQLENLRYVARMFEKNWEWGDMDNVDRWDGERSGSSDGVLVTPASSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAI4</accession>
    <name>A0A8H5GAI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAI4"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="255" mass="28967" checksum="ACB1016CD9C93F74" modified="2022-01-19" version="1">MTLKEIKDRFKRDLKALAADEVVKNKIMNARMKGMDISSYNSIFDTYREESDYRETALLDFYKAGLLRDLWKSVAGTWPKWKDFNEYRERAMDLHLEWINEREKEGRSRPFSTPRTNSGPPQGQTVASVNALMNMGPGANLSFTSLSKLTPEERDQLRKIGACFACRQPGHMSNECPIFPNSTPRTSTAQNTSQNFPPCAVRTAKTVAQTLSLSSSHNVIKDISDMMNKVKGLEGEEKEQASVYLKDVMAKMMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAN1</accession>
    <name>A0A8H5GAN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAN1"/>
    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="23876" checksum="43B3F3BDA4D59467" modified="2022-01-19" version="1">MSATATMTEVAVHDAALKVSGGNIDLNSIGEVEARKIMSLEHKALGYRPPPGSLASEAQAAAAKHPQGGPSPPPPDLLKKAALSDAARIESERGHPIPKSTVVDGIDLQTISEADARKLMSEEHKALGYRPPPGSLAAEAQAAAAKHPQTTTDKTVESSVLQQAAVKDAARISAERRSRSNSPPQVDPSKVNEDEAKKLQSLETKLLDSTAGTVSAEAQSKLDKGETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAX7</accession>
    <name>A0A8H5GAX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAX7"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="83702" checksum="5ADB5F6FD965A4AF" modified="2022-01-19" version="1">MTERLCSPLHSRALTSELMFEQYRVPSLAYCVDGIMSFYHNSPPSSSGIVISFNTASTSIIPILHGRGILSHAKRLPWGSSQSTDYLLKLIQLKYPNFPTRVTQSQAAWMLHNFCSFMPNPNPTPVVGTTNTYLSLLRTFSKDPSTLTEHTAVVQFPWSSSPLNTFDTNSGPGRSTPDPATADAMSIDPSSEQAKLEKRREQGKKLQEISAKARLEKLKQKEEDLAYLLELRRGRREEGGDYYVGDGDGDGDVGDTSHKDDIDEKWLKRLVREGFDDEKRLDDTIKKFEASLRKSKAKDKDASQAPEDQQPVEPEEPSYPLLSIPDTDLTEDQLREKRKQKLLKAGYDARVRAKREKALKEERERVEREREREEREREEKEEEEEREENFGGWKRRLRGEQEALISRIKARSRRRAALNTGDRKSAAAQARMKNIANLAGDERVNPKSRNKYSGTGGVAGSSAGAGSGGASGGGGKRKDKGEDMFGLNDEDWAIYHKIAKRNEPPSSDSEQEDLSKLSLIEQKLLTHDPSFTFQDTHASLSHYSQHSAILAAFKPSFYGNANVAVAGANANPGVGVGVGVGTPSTAIGGIDDIASQWQIHLNTERYRVCETWFEPGLAGVDCAGLGELVMGVLNSVSNSSSSTTFLSSSSPDHSPDSIKRLLTSNILLTGTPSLLPGLIPRLHEALRPVLPVDLPIQIRRAEDPGLDAWRGMARFAGTEEFGGGGGGRGVSMTREEYEEYGGERVKRWWGGNWNGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDB0</accession>
    <name>A0A8H5GDB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDB0"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="67402" checksum="B020FE040D04A50E" modified="2022-01-19" version="1">MNSSKMSSNVLMTTVPVFSGVDFNIWANILLSWLQATGLSSVLGSDRPSDATVSSVSPLSAEDTAAQAEAITAALKKQADWDEKNDKAIGSIKLRLSPAICQKTLGMTSAKEIWATLKNTYGKPGVSAVYTDFKRATSITIPNDTNPSATIELIRMHFDRVSAAGISTDTTDSTIPTTSITKIPNFLIVMFIISKLPPRYEYIINQYTQLSISQIDNQDLDELQSEIVNVWESRQGALKGKPQANRLSAVKRKDGNPSFQQQQQQRPSGSSRGANRDNKGKGKGKGKGKGKAHFRRGGRAGKNEQAKRQAQAHLVHGDMSPMMHTVTFVDTPAAVDSHADMGCAQEEDASWNEDTLLNTSELRSVFGSTTMESGVKVLQDTRTPVPLIDRLASDPAAEIMECRIHLGERFQNPEDPLHIYGEGATPFRAVVNACASTGTLSLVQRLAAVRSEMQSGSLPAHPSGMTTQSLPSSHVASPTPGTTSTGWEWLTPHLGNEDGRYDELLDWQRDATVGLGGMEMEEELPSRVPTPSSMPELRSMSPSLSSTSDLEYMSTPRSLSRMSHSTDPGEATSSASIAAVETWSDGIRSPRPSTPAMVIGSAANNYGWSLDSEVSGMDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDJ9</accession>
    <name>A0A8H5GDJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDJ9"/>
    <dbReference type="OrthoDB" id="2897205at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="805"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="858" mass="96168" checksum="BDC6F18B9D06BF55" modified="2022-01-19" version="1">MNTHGSHRSWQIQTQDQLQPQLQNRRSSESTSSTTASGSGVASASTVVQEQAELYIGGGRSIAESAKCTSGERPRDTYTSSTSCSSIERNRRKRKFKFSDLLRFDGDGNGKERNIANTDKNTKMRRIPSFFAIWRKKSKSSPQNTRTIRQEDSSSSCSNSSFHLSSISTSSSSSSSLSLNLISYPNSTLSTVDPNANPNSGNSSSLARDPLHHRHHTASPLHIPTPAPFTSAEVIAIDDDNYRLQVLRHYLTSIVNAQTERAQALRKQQQEDRNALEEFYSQIADLKREAREWFDCTNLEAKEEQERIEEEERRELRRMKQNNFAGLGARLHSDRKGKGKVGRSRSLKTLQESRIKLYEEQVVLKYPIPTGMRVGEVSSADNFGWRWLQCPNRVQVLLPPDASYRYAVFLKMEGKAIANAKAHTSISPSSASTSSGFTGSSESSYSHSNSSLSSSSSSQAPALSLRKFDRARTVFISACFFSRPEYPVRGITPTDRRFALEPGFKCDAIDEIVERNLEEPVDMETFAKYFVTNRRVGTVGAMDVCSRRWVKVEEHAQVLFPPDIAFQYYTFLTSSESTFSLSHTVFMETLLQQCLVNSKFLREYEQEKLYILSRNFFAPVIEALRVFARANDIKRAKAVMRFARYSPELMVRHTNGKRRVTGDNIFDLAEDVEEVVNGNGKDEQKNDQSVRRSLKSESIRGRMPKEKLVSKIQETMEELEPIHEIPSCGSDFEDDDSSMSETSSLVSITLVGTRDHTPRQGGSVEGDGAPTIVMEGFGKKTKRRSPQAVSSSFWTSPLGWLTSSRSFATSRPSTPSPSTLSTSSRSLACSTSENAKRSGPRQWLVRGMVFSGKTTHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGF8</accession>
    <name>A0A8H5GGF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGF8"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="15"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="396" mass="43436" checksum="3F90FB9479536B5E" modified="2022-01-19" version="1">MTAQNIANACSLLAEACKDQNKIPGAVLFAADRSGKTLIHEAAGVRQLGSSEPMSKDALFWLASCTKLITVISALQLIEQGKLQLDTPVREVVPEITKLEQGYNTLTTLRHLLTHTSGQSYSFFNHDTAAYFAEHNLSPVGHKLASIMAPLVAEPGTKLEYSTSIDWVGLMVERVSGLTLDAYFKKHIFEPLGIKNITVLPQTGIPGGVKPHLAGMHFRNKDGTLRAIEHVQEMDESKQELQYGGGSGYGNASEYCQILVALMNEGTHPVTKGKILSPAGVKELLKDQLTDEKLIRDLDRSFDAAQPDFTNPFIMLEGVPKNWSFAGCKTPQGLPTGRTSQSVWWAGLANVYWFLDNESGVCGMIQSQILPFYDPHVLPLFFMQIEPELHKAVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGT9</accession>
    <name>A0A8H5GGT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGT9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10835" checksum="13AC64959373886D" modified="2022-01-19" version="1">MVKQMCIRHNGSLPEEERRFYRQVIYHNILESAQAIIEAMLNIGLLHSNQAAVDKISDLRRHTSYPVLRINECDTSVLDRPNSRESDRRTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH32</accession>
    <name>A0A8H5GH32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH32"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="310"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5364661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="54154" checksum="2562BF358235FF82" modified="2022-01-19" version="1">MYYRHLQNGQAIASQRRFGSGTEIIKSRMSIMKPTIIPVTVPLLMFYPMTIRPTLPFSLFKARSRLFRYPNPSETIIQAVVEKPLGPSLPSSLEKSAETADTESALETRIRVSTASSLTLCEDDIYSEGSLRSCLVVFGAMLLGFTFGYVNAWGVFQAYYEEYILPSTSSSAIAWIGSSQHACSSLIAPIVGRLFDLGYFHSILITGTVGLVLATFLTAECHVYWQFLICQGILFGISLGLCDALSLMVIPQWFTKYRGLAYGSIRMDNAYIRILFPVDFTMRRRTVAAEDSLSASDQNFFEFRPLKSPAFTVYCLSTLIEAIGYYALPTYVVTSSQSIGVSSSLSFYLVSILNGSGGIAHIFEGWGADHFGAMNMQIPFTVLTAVMLWIWPFAKTQASLIIVVVFFGLSSDSSDTLPSTAVASMGNPGELGRRLGLLNLFLGIGELIGPPLAGKVNQSFGLEAMALFSGGMVLFGLLLILTSRNLALGRWIGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHA3</accession>
    <name>A0A8H5GHA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHA3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13100" checksum="06A22E162D791152" modified="2022-01-19" version="1">MSLYPGVQSKGQEELDAVLGKGRMLMFDDHPSLPYIEAIFREVMRWHPAILMGGSHESIKDIVYGDYYIPKVGTTIYANIWAMTHDPSVHKDPECFIPERHLRKNGHFENINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIA8</accession>
    <name>A0A8H5GIA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIA8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="333" mass="36428" checksum="D20BBF7D467D86DD" modified="2022-01-19" version="1">MDYSPQIQTSSYFYGCRKFATDGMSVQRIKGTQISIRSGKSAEPAGHADFFQEAGTFLKAMEEVQNSPATQSQSEDSSTFSVFTNASNFACRGLTIRDVGGDQVTMSGDVNAEMIEEIFSQIEKKNERRPHQNHFGWGKDHQNSQGDDGNSVKRLRGGRITMRNTQAKGHAGFFTEAAEFVKAMPNGDNVQDPTSPAGQGAQYNFYQNCDHFAVRGLEVAEADYELELPENNVNPEVIQMILSHLEKQKSAQKDPKPQRSQPKTQIVIFGSASAQRPGPELGFSRHCAARNPGRALEPPVSPTWPGLGTGPVEEELEYDDGGSGIPGGWSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIE0</accession>
    <name>A0A8H5GIE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIE0"/>
    <dbReference type="OrthoDB" id="2142213at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="43887" checksum="4E1E133F858531B1" modified="2022-01-19" version="1">MTAYTKVSQVESGSTGSLLLPAPPSSLSSSSSSESTSLNTQAASPSPSPTSLALPSQQTDFAFDLSHNLVSASSNVTTLPSLPDNCVSFTQPGANLECPSPGPSNAESSSGSSNATATATGAMTAYNITFDDCGSPFTVCLCNTGSDNSSITSTITSSSSDTSDTSTTNNTQSNPMSLNTILDRFSRVPVGLRRYVNTVVVVPAPQDNPDPRAYTLKSGDIHLFGDTGVNIWVHESMHAYDFAQDINNPLSSSQGWQDAVRADSCVPDNYSATNAVEDFAQFGVIKMYALANQGTLPQGMQPECMYNQLRFMDQLPLFNATTLFGNTCHIPHQNKNGARHTTSPPFLNKTSKMPISFTGESGTAFPATITGLMSTVAPVPTTASSASDRVVTSRLIRLELVVTFSALLALFALFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ06</accession>
    <name>A0A8H5GJ06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ06"/>
    <dbReference type="OrthoDB" id="2917041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="634"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="750" mass="83989" checksum="ADDB654C4F0E8E63" modified="2022-01-19" version="1">MVGRPKSQNQKNRKASTENAMKMQAAVEAWKEEVKKSNPRSLRCFAADMDVDRKTLKRQSEGGQSIQDFNSTKQTLTPAEEATVADWITRSCEQALPPTPAQIRAHAEYMRKTIHPQKKPIGTIWVNEFFARHPEVSTGWINSLDIQRAQALNPVIVKSWFDLLESEVVAKNVPAECQWGMDEMNLQRGNLATQRVAKVQGKKMAHKQGGANKEMITAIVTIGANGEALAPTLIFKGERIYDRWIQDNPANATFVTSLNGWTDQEVCKEWLQDVFEPATQEKANGQLRVLYMDGHSSHFTTEIIDFAMAFNIMIVGYPPHCTHALQGLDVVCFAKMKSEMKKEINEFEATHGHSVRKDDLTGMFGRAFLRSFDVDTVMAAFQKTGIYPFNRNAITEEQMKPAEATSVQGSFTFTQTSPIKAIIKSFRVYKPTRFDISPSHATSSTSTPDTPSDLQQLMVFPSYNEPQTPNHSRSRSHPDIDPALLDDTPSKRMRIAFSSLSSTSSTSFLVSQTPYTSDTPFSHAPDKIPADIQQPDWTLKKVSANPRHYCNKEAMGKTIGDLTEALGDAELQVKVLKLNQETMAAQAVIADLHLQKMNQIIYSKEQEKIAKEHANNKFVLPNPGHGHIWTKEAVADTLKKKKEAKEKEAAEQAERVRKREETSQKKAALELEWKNCREEHKKAVEAWQEDCKKACAAGIKTKDLPSKPKCIKKKALTTLMMGTGDAGDEDVDDSDAGNVLEDEEVDAEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJQ4</accession>
    <name>A0A8H5GJQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJQ4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="128" mass="13983" checksum="EAB01A71F1F6388B" modified="2022-01-19" version="1">MKHQRSPNTSPSLLDEYNISFKRLQRRSRIIPVIGEEVYTPSNSADGAIAETLVSTASTLAADLPSDSEELVEDTVEDFTPRLADILDGEDGPLATLENEEDIALDMDVVEVEVNTSLENDSDGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKB7</accession>
    <name>A0A8H5GKB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKB7"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="285" mass="30032" checksum="DE41A69411E704D9" modified="2022-01-19" version="1">MILILNLIQIQAISDKNLDLQPPTIHFNFLLLTCICQQVGRLIGIGFVESVDTHPSGPSLLRDVAKKDLFRLGLSVEVLPPCSSNTESLRAKYTTSGSAATKKKRASGTNALVNQCVDSSFFGSITVGNPPVPYNGRVVPPVETHLPSPSPPPPPTLAANSVLAATNPPKATPPPPPFSITYGSGAASGTLVSDTVAMAGFSVVDQVFAVCDDVSDGLLTDPVSGLMGLAWQSMLSSGASPFWQTLAGAKDAVWDELLMAFQLTRFNQDPKVRQQEVGGSFTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLB0</accession>
    <name>A0A8H5GLB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLB0"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="13614" checksum="6F1B09BDD62DEE2C" modified="2022-01-19" version="1">MAMTTDTHMYRGPLSLKIPPHLQRLAIHSRQLLREGMGYEGAKESGRTAMGSGSLMETEGDCRTSDCLLIRPRPGKLGLWVCAGHTGHGMSRASVQHLPVMSPTPPQPGTTVAGSAHVGGVEFFSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMG2</accession>
    <name>A0A8H5GMG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMG2"/>
    <dbReference type="OrthoDB" id="2670057at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="452" mass="48487" checksum="C31909DE958352AE" modified="2022-01-19" version="1">MVFAPSLRHRHVLRQLDNDPLGVPTAEGISTGALTAGTASGTALAFDTSAVNNGVTQGPAATLTFSVPKTTSTTDAPSQSESDTASSSSSSSNQIPIGTVIGACVGAFIGAIILISFGIWMYRRSDAKHRRRSPTRSARKSDQWKRLGDNEDKWDGMPKTREISGGVSVAPADPPAEPMEKLTMFKKSPSIRTNTTQAHTEEVLSNTYNFDHPFAQYHPNLAQQLASTHEAEEPTVKPFTNRAEAVPSWDGDASMQGSFLSLRSNRLSGTMSPTFDMAIPTPPLTSSELHRWESAEVINFEGQSAEIVDPSNENSNNPFLHHTEIRRKSVNNPFFGAQPDTRRASVSKGSRSRGITPGLVTTPPSDDINPFSDDAGQYSKSHAGVDSMASNASNDRAIQSLLAALEVRPEDMPRVASMQPSLLSAYTEEDVTDAFPVPPGTHSTAFNANSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMQ0</accession>
    <name>A0A8H5GMQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMQ0"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034541959" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="35804" checksum="CEA04E05F5ED877A" modified="2022-01-19" version="1">MSSIASSILRLPFTIGTIWAINLSMTPPNPPPLETELEKNRCEASENGDFRNDTTETVTVRRPLSKGTKKAPESKLPLDKDKNVAKFPLRIGVASGHWIIFASSCRHPLDPIQRFTVGYLSPFDHPFPEEDAAYIPETDFIVDVLRVSPQLILGTVMAMMGGLLRWACYRAMKELFTFQLSVRKGHRLVAWGPYAYVRHPSYTGALLAGSGTILSLVVGRGSWARECLWEFLFMLVRSCYWRCAPGNSLNPSMSWRTESFDLVPTLVVLALALALTIVVFVPRMRKEDEMMEREFGEEWRNWSRKVRWKMVPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMT1</accession>
    <name>A0A8H5GMT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PIN domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_003607</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="923"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="549"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="696"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1178"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="762"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1249"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1267"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1288"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5367530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="149056" checksum="41D5842C9FD5CEA3" modified="2022-01-19" version="1">MGVKSLWTLLTPVGRPVMLETMEGKTVAIDSSIWIYQFQATMRAKDGRTLVNAHVLGFLRRICKLLFYGMKPVFVFDGGAPALKRSTLNERRKKKSGAAASHAKLAEKLLAAQMRREALKHVKGSQSSKGKSKVPTGPVELNEDTVFLEDLDPNAPKSPAKKKAVAEPKASPKKKFYDHDPYKLPDVNLDEQVAKATRSAAPDPRLATEEELRAFIEDMRPEDFDVTSPAFRELPTEVQYEIVGDLRLKSRQTSHTRLQQMLRAAPTPLDFSKQQIKQLQQRNTLTQQLLTTTDSIGKAHISIPVRIASERNKEYVLIKNEGAEGGWILGIKDTGGTTRDKPIVIDHDSDHEVGEESEDEDDMDMEEVDIPASATDVDPDLRNYRRKMALSSIATRYTPKKLAPLTTNPTAHTPSVPLFDLEDEEPGTEQLTANDEDIWGDDEEVALALQQSFDQSRSVSVADPDIEDQELAFAIQQSLDHKKATSRSTPDLERKKRLSAMFASGEQPVASSSKIAPEQITSTVGSSEMSDSSSSFSFGKPFLLLSSNPRSQLNSPIKEPRPSAPSPAVTPAKSALPTSGGQSSVFEKGSVSTSTFTSLLKPHVGGPAPAPAPARAAIQASPVPINTSPSVVYSRTDDKQNFVPSAAVEPPTARDDADVDGVGAHVEQTELATTSLPGSDDEIEMEEVVPPMQSTAVDHYAAPSKLSEGQSSRFSSKSKDGDEVIIAPTRDTEAIPMESEAPAPLSLSDSDDDMEEVVPSIQPASAHQKTATPKPTIGQFSNSLDGNEVNTRPTSTINAPTIHNTEDTSTIIPRSSTLDNESSTFILKPISRSPSPDEFAHRDSSPRPPSPTEDWDAAQEIDPVAEEGEFARFMSHVKGRDINDVRREIDDEIRVLDQQRKNALRDSEDVSQQMITQIMMMLRLFGIPYITAPMEAEAQCAKLVALGLVDGIITDDSDVFLFGGQRVFKNMFNQSKTVECFLLSDLGRELGLDQGTLIRLAYLLGSDYVDGLPGVGPVVAMELLKEFPGDDGLHKFKHWWQKVQTGKDKEDDNTSAFRKRFKKKFKDLYLSPEWPNSAVRDAYYHPTVDESEEPFKCGLPDLDALREYLREELGWQQNKVDDLLLPIISKMGKRTKTSALNKQGNLNEFFDVSGGSGTYAPRKRQAYASKRLQQVVSDFRKKRKSVGASGSSTPALDEDDDNDVEMIEGEEGDGVQEDEAPPKKRARKSKSTTVAQAGKGKGKTKEKSASTAKGKGKTKSTSGSGKGKGKATGKGKGKGKGKRKMTETSEEDEGIDMESSEDDFEPEGVSTTAPVRATRDGTGAEAEAVDVDVNDPPPLAVNLRPRPKPRPAYKGAARDVDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNG3</accession>
    <name>A0A8H5GNG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNG3"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="7">
        <location>
            <begin position="557"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="956"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1222" mass="136381" checksum="AF500BEBB69071C7" modified="2022-01-19" version="1">MMDNPASRPNLLASGHHTRENSPMSRPASHLSLGNPATVPRTPNPMTPLPLGLDNAAISAVSGSAQRSPESSRPLNVTDALSYLDAVKNQFQERPEVYNKFLDIMKDFKSQQIDTPGVIQRVSRLFHGNPPLIQGFNTFLPVGYRIDISDNPLDNTITVTTPMGTTTQSTTNFVPRAIPPQRDIPGFGPNIAQPFGYHPIGSPGILPPLGAGNLSRSMTPQQAFQLGHAPIPYDQPFSPGFQQNPQTTAAANFLGALNNKNTVEKQQQEFNHAIQYLNKIKARYSDDTNTYKQFLDILQTYQKEQRHLQDSQVYIQVQQLFKDAPDLLTEFKDFLPEIVGGNSIVGPSMSLPPGGPAAGPSSQPWQQSDTPVPGSPDKSPKKVPLPVKRRKRAEKEPTPVPPTKPAPSRAAKKAKYAHKTDTGSPTFMGPDSPQPVPAHPISHSSMIPPGPQGQHHQPLPIPLNTAPDKLMFFERAKRALEPRPVYEEFLKLLGLFSKNIVDVKTLIQRAQVFLGEGELMAEFKELMGWDSRQENVENGPPGSIRTGPPEALSAQPVDDGQGPSYRRLPDSEIRLACSGRDELCRSVLNDEWVSHPTWASEEAGFLTLKKNSFEDALHKSEEERHEYHVHLEAMSRTVAIFEPLAARIEEMSAEDRAAFKLKADFGGPSKCIYHRILKKIYGRDSGAEIIQALQDCPSVAVPVVLMRLRQKDEEWRRAQREWSRTWREVDSKNFYKSVDHQGISFKANDKKNITAKHFVGDIEAIRTQQQEDQAKDGIPVFTRGSVGLQLEYQIQDVAVLHDSLKMIFTFLDRSQGHYSSLERRSVERFLRNFVPLLFMYPPAEFIAACSSNPDGFSGDDDGSTTADSNIDHAKGGGRSVGSLQSGPQSVGVAAGDLRKKLLKTAKDKAEGRERPRGESASTGVSRAASPFADSRHRSPLTAQQEEEAPQDVWIRESSTTSGSQRGANAERSITSRVERPFFANTTFYTLLRLLQLLYSRLLMCKETGRQLAAKKHADLLANPVAVELGLDDPNGPATVLAQAMEVNNDTNVVYMYLLDACDKVFSGDLDQIAFEEHMRWFFGNKAYHLFTLDKLIIALVKQVQTIISDAKCQELWTLLQSAHNSDAISNQDIIRYRREAERHVGQDDHLYRIQWIQVTDSLRISLMRSEDASVDGVRTAESRWREMASQWKKEKRTVFEKKPGREEAYVHGEPDEYRNQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP24</accession>
    <name>A0A8H5GP24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP24"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1273" mass="140729" checksum="A8883082E6BAA6E8" modified="2022-01-19" version="1">MVVLLALGVPPFPETAHVEEGIRIKPANVELEEDGVRIALTIVDTPGFGDNIDNEFAFQEIVGYLERQYDDILAEESRIKRNPRFRDNRVHALLYFIPPTGHSLREMDIELMRRLSPRANVIPVIGKADSMTPSELRAFKKRVMEDIEHYDIPVYNFPYDVEEDDEETIQDNSELRGLLPFAIIGSEEEVEIDGQPVRARIYPWGIAEVDNPKHSDFSRLRSALLNSHLGDLKSLTHDVLYETYRTEKLSRTVHTDTHDSSILPEELASQSVRLKEEQLRREEEKLREIELKVQREINEKRQELLAKEESLRYVGIHIEPISDLRMSPNLGIWRVVWQLRVLSRNSGSRSAPEKVYVLRIGMRYIPYSETLLFRMLQMIIEMWREKDIIDKRRFRRKSPATATMADSDRDDQRDVPQTTSSLSSRRRSSAAHIRPAAPPPNLPIPDPPRSQYAMSHSPSPNLAAVAAYSQSRPIPVDDLSDPPPQSILSSSRLNMHHHQQSTNHLSVPDPEPKSEPRPPSSRKALTRALELAREAVQLDSTNDRPELAVAAYAKSVALLSEVMERVRRGEDTTESSSRRKNGRRRSVVAQEEEVKRLQNIHDTYADRMNILSIIYSIPPPPHPASSYYSPTNSTTTEPVSSTSPTSSASPSSDTDNIPGAVDTTNHTPDDVLDYTNNSDLQYSNDTSQEGIAAIGAAMFTRDTSVRSDISGLPSTSSHPYAAHYDSPPQPPAPSAPVQTPRLSVSSRRSRASSNLPPPPPPPSMSPPAPPAPVVIEPEILPVYQNGRPSDMTRSRGDSVSISHRRTGSGSKLASLEEEELERRDDGYGQSRPVANGSQTQPYHSPPLPTESLSGFEPPGTPKVPPKDVITSPHLTTTARPRGNSQISVSTRSETSSHSSQIINTSTNQGTIHQRRSNKVSTRSASPAESTTSGKGVASASSSTHTGRSRSNSQPGRRPSIGNGRASPSPEQRPPLPTNVPVPQRQIVYPQSPPLPPPAMFGQLTVQTDLVSNSALQPVTLMTVGVPITPVSPLPPIAPNDPMRKPYHLMFLLRTTMTSSTGGYITRRLHVPQEVWSQGGAKLNNIAEKVRVVGILCSALEELQALSSELFGAGNVSSGMALGIGSIGRKEGEAWVAKLEDFSTVCDGVVANFGKKLSVGEGFVLKKTTWSDKLGRRFEKITNGKNLDSPASYVQGLKRLFLHAQLLDEHTKAVTSQPVAPAYSALPVDIRAQADVKLKRSSEFFASVVLTFVIRDLSQLLDKYAKKCEKWLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPY0</accession>
    <name>A0A8H5GPY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPY0"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5369049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="63437" checksum="2DBF9F52A3F9333F" modified="2022-01-19" version="1">MTSDWQRRCAERKQAQLESIPAEWIIQCPPDNQLNVQDVPAKCSLLSAHELEITDTVDVDVILQKLRTAEWSSFEVTTAFYKRAIVAQQLTNCLTEIFVEKALARSKELDDILKTTGKVVGPLHGLPISLKDQFAIKGLETIMGYAAWIGRYADSDSVLVEILNECGAVPFVRTNVPQTLMWGETYNHVFGRTTNPFNRYMTPGGSSGGEGALLAMRGSPLGVGTDIGGSLRIPSAFCGLYTLRPSYERLPYCGAVNALEGQESISSVLGPMANSISGVKIFTKAIIDSQPWNKDPLVTRKEWSEKEYKLEYHGGGKQLCFGIMWDNGVVKPHPPLQRAMAMTKSALEAAGHKVVDWEPHRHLEIYKNSETIFAADGGDDYRIQCELSGEPVIQTMSPQEDAHESVMDEPLVKSLVGKPYHRSALELWQLHKEKRDLRKSHLDYWQATVSRTGTGRPIDAIISPAVAYPAVPHGMNTDSFYTTLCNAMDYTTSVFPVTFVDSKLDDPHPPHEFYNHEDEAIYKLYDSKLFDGCPVGLQLIGKTQEEEAVIAMTEIVDKALKNFKMVKGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ55</accession>
    <name>A0A8H5GQ55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ55"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF131">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60479" checksum="76733C2B6D8C54D1" modified="2022-01-19" version="1">MTVPLPNGAHNQDHSNGTAYPNLKNIFFFAIPAWGHNKPIITLAYRMLEARPNLVITIFTSSMIYPKLLAEIAKIPDHVKGTSKDQRINVIDVCEPMHPLLPAPAFMPAFEALWKGEPVKCLSSGKEFIGIPRPTVAVIDPFAGYVMEAIREITLPYPNGPLPIIAWMTAAIGPCIHLFGPKELGGIGLSGNLSVKTIRYGTEAEILSQMNAFAAKPTGKVISIPGVPSMYDYEQLPQLAPISGSLVEEIGRIYISKCDGIFTVTASCYEKAAIEHVKENWLEKPLGSVLYPIGPLSTSDSSVRAGDDPLKVGPGEEQSPKALAIEFLDMMRKKCGEKSVIYMSFGSIFWPSDDDKLWAVIEEILASGTPLILAHPSPFMKPIGDDKLRFIREHPLATEFEWAPQETILSHPATGWFISHGGWNSTQEAFIYRVPQIFWPFGGDQPYNSLVISDHHKAGFELINIRTGEDGTKPVYRFKDLPDSKQPTFTVDAVRNEVRGLLAKLKGEEGQEKRKNFEKLGAAFLAGWSKDGEARASMEKFLKKYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQU8</accession>
    <name>A0A8H5GQU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQU8"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="32376" checksum="5543195628FD0748" modified="2022-01-19" version="1">MAIMEGVDDLTQLWGLIQDLSEQLNQNRSLSVSLYTQAGGVKFYLFCSVLCWTVAGVLTAVYSQATHSQTGFVLRRFNLDKTKEEYESELDRMNNAMATENRELQHDNKQINALIKEYEQTLDTLMSSFRNRAKDVQERELSLVREYETKLLEMEERNATRELAASTTLSESLSKMSQLLRQCLRGQGGEQLRDLEESRRRRKHNASESQSQSQAEGEGQAEKEDALEELEEFVHEREPWTASDVTQAEWALEREIELARLERENEELRRLVGLSPAGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS65</accession>
    <name>A0A8H5GS65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS65"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35515" checksum="68F1B53B9EBFCADF" modified="2022-01-19" version="1">MISLHLFNLLFRRGNCTKTGFWLTMVLGWFFIVGVVLLGPAFLETPEKGPYFGISGPWCWITMNYPKERIFLEYFFEFLSAIFSIVLYVFIILRVRGNLIRSDGRWHLRFVPREESWQLSFERDLIDQSMLRVAQSMVWFPVAYTIILIPITLTRLPAFAGADIPFGATVFGAVVFNSTGFVNVVLFLFTSRLFPNMKDVPEFNTKRSKHLSVFARGGITPFMLERSDVAELHEERRTASIRSAGRLGTDSNRSSVTSTTLEDMKDVCRTSFLSGQSQIGLVVLRPPSPASCKESSEGKSPVYYLSFTKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTC9</accession>
    <name>A0A8H5GTC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTC9"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="75711" checksum="CC9920625AA4C066" modified="2022-01-19" version="1">MNAIPETLLSTVQNLKSHDRLAAHVTHPFAASAETSCNALQDIIQTTDQVAGALNHYLATNFTNTKLVSLLRQQAGLSHDFHLSDQNVQQTINALRKCSRTNYGENIPLDRNILVEWCASRFQVWGALVGMETFQEERPEGVNYVFGGKVIVIDVDLLIDRSNSLNPSISVSSVKTSYAISPEPESSTNGSVALDAFLKDSFQRYFTQVQCPEDVRDPLETARLASIIGEHLRYLVMLDKLAEQKEDGGVRWFVDVNDLCNVVEGFSKSEAQAVASSLSLQTAPLDIYLLRGHTLPLPYLTSPSLSFLTYISPLVYLSLLRSGREPESQLDNNVNLPKFDIPMSHIRHHVASLPKGVTVATLTLSKRMETHLFPASMSMPTLTTRPTFPLVPGEFELEHVFPSLADVAPVTLDSSEAPGRQFWMLDFTHGGKSLGVVMSQSKMREIELVINPLSSMESLNSVGMMSYGTGSWLALLLNPPDPISSERYTALYTSPTGAHPPLQLHLTAPEEPGFMLQKVPVHSMREVWGVLEVVREQCWLNETLSSCKWTTEGLKIGPEQPEGEDQATEEELEAMLSGTMIPRKIPVNVSVPLNSSSPEPIFEAPGLDSMSVSVNRRRPRVVMTSPERPPISGLVEISVAYDETKPRGISVEVNGAMGVDFTPEALEEICRRGGTFGLSGRVWASSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU68</accession>
    <name>A0A8H5GU68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU68"/>
    <dbReference type="OrthoDB" id="3033638at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="812" mass="90703" checksum="1A6E58AC8F7CAC18" modified="2022-01-19" version="1">MCLQWHPGGLPGSHPPFPMMIKCDTDDEAQHIFSTLQPWVLSHLTLAPSALISALQSDTQIQELGRLLDRVPGQKYWAVRLGSRVGLYLNSVDAVETLDQSSKDKFRRAFVFDTFVAGFCGMITQDPVALEPTHDYNPVTDLDEATRLRSEGLAYRPQLSLNPHPTGPPPPPLAAQSPSQSNQSNVVNFSVEIVPPALEHALMNTWFAGTPSRRSPLILCQETPTRGPASSCTPRRQGTPATPGRTLNRELGYWPRRYLLSHGYSNDEVADIEELFDGGGWCRGLQGWFGRRHLSTITPPMGRKKSNVQFERLLRAAQKHGTSTRQATRYRAPHKPIKLTNAQKAEKKQARDLDNKRFKTRLQQAFTVIQSEALAMKEEFGKHDLQWYMDTIMQSYRLKQKKKSLGPFQAFVHKQMAEINSAIPEGQPRKKIPECIREIGEKWRSMSKDEQREMTAEVLATLEVNRENRELGGHNSSLSAFHDIRTTMEDAKLLLQRLNARTGAEAAIMVVRSNQDHFNPPDAWVTSDRVESFFEMVFKENPNAIATRLEGYCIAGIDGCTRNYVQETVEMKKELVQIINQKLQAAAGKTRIPRMYYKNFDEHITKNHGLKLIGWPLEKFCSPSELATRVEIQIVKNAFESDTAHFYKMSNVERKEWEEKRFQAALQQTEQQSQTVVAPAALPGTAAIVLPPASGLSQPDLSEPTPMPSPGEDTNPTQVTTLVPGPDANPIPVTTPMPVVPASNTAPVIAQPAKRGRKRKAFGDTSGAEVNFVNSMSVTGPNGTVLLQKPARKQRSDKGVKRKVSNGNEMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW99</accession>
    <name>A0A8H5GW99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_005061</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW99"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5372236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59777" checksum="472D3B67267AD222" modified="2022-01-19" version="1">MTPIVSVFLCILTLYLFRTIRRNISVRYPPGPWGLPLLGNALQLPTVKPWHTLAKWKKTYGPIVYLNMAGQPMIILNSKKTVEDLLNRRAAKYSDRPQFIVENVLTGGFNLVFLPVGERWRKMRRASDHDLGFKNTVNYYSIQRNEAVFSVHSLLSDPDSWRSHIERTSSSIALSLMYGLPLIQSSQDPSIHWMNHFINESTIAVTPGTHLVEMVPFLRRLPRSLSKWRQHAEKSYEEFATYFEERFRNIKKFVESGQEQRPSFCVALAENQANSKMSDRECSWLAEVYSGAAHETTSSSMMWFIFSMVLFPHIQARAQEELDKVVGRSRLPSFADLKHLPYIHAVVKEVLRWRTPLPMGIPHVSSEDDYYDGYYIPKGTICIPNTWSLHHDPDIYGPDVAEFRPERHLDETGQLKDGLLGLSEGHFSYGFGQRICVGRHVANNSLFIAIATALWTMRLEGAKDSDGNVMLPDVNGEEENGILSRPPLFAITATPRFQDADTFIQEARDEVVRENFARPDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX23</accession>
    <name>A0A8H5GX23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX23"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="23513" checksum="F05C9C6F3E5248E2" modified="2022-01-19" version="1">MVDVDKKSTLWKPVRVLEAIGDIFPSLEKLEFITKPTKYYDDMAKYTPRILFHLPKLRTLRRPTLSLDLEQDANDKLDTDHDRDLFRYNRCLHRRHAAAKEIANVDVIGNISLKTMRGMRCGIFFVIEKDDNNNDTEGTGVQGQCSREGRARMVKTKPKGRVVDEDRRGVWAELPGGIGPDGMIGDTRMETFRPGRSEVYSDPGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXQ1</accession>
    <name>A0A8H5GXQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXQ1"/>
    <dbReference type="OrthoDB" id="3352225at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="355"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="726" mass="73811" checksum="CA9D96D42751B5B1" modified="2022-01-19" version="1">MTPAPSDGSHAHGRSHSRSHSTHASPWVGPGSSLPPQGYHPSNQWAPSSPMPAQPGFIPPEARSHVPPGGGGTPLPSNVNVEFMGGYPNFAPTPFAGNASLPAGGGGGGMGGGMGGGMGGGYPGMTPFQAPMQGSPWSPPGMAPGMGMGGMGGGMGMGTPYMGAGMGMGGMAGSMGGGMPGMGGGMGGMGGRPGGMGGMGMGGMPGGMPGGMGMGGGMPGMGGGMPGGMPGMGGGMGGMGGGMGGMGGGMGGGMGGMGGGMPGGMGGGMGGGMAPSAPAPDPFSFGQMAETLHSLHPSSRLTGSTGDRLPPFTPGPGYGPVLTPFQLSILGVLPILNPLLAPPSELETDETNPYLKWNLLFSSAMCQRSDDPPHVSWSRGRTDPATFPRVTSLTLIPSTRSAAHLPFTVTINASNPDAGVTCGDIVESLSQALYTRTSQSVFGILTSERRQVVARAYRFNRSRSPGVPGGVLGEGMRRIDLLGGEGCWGGMKEIEGTREVGVYISNRRKALTDLSNATTPGGGVAAAAAVVKPEGITKRADELPWCTYEWYNLTSYPMTQEEARVLEERQQMVEREHREEGERRAREEGERRVHSSSRDGRRRHASSRADRERGGIEVQPSAGGTASGRATPSQAPSSRPLSTATATSITPTLASSMAPPSMARRSSRAATVHTVDDDDDDVHYIHGHGGEDEDGDSWTDADVRSARSGASGRSSRSGRTSRNNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXU5</accession>
    <name>A0A8H5GXU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXU5"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5373143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13410" checksum="3455B4DE0105BAE4" modified="2022-01-19" version="1">MPVVDFKTNVKIPNVEEYVKDLSKLSAPLVGYAEDYICVSVLHGQPMSFKGTFDPAFLLSITLIGSTPDNNSKLSAAYFEHFKKTLGIDDDRGYITFIDPEKSNVGFKGMTVEQVLAALATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYK4</accession>
    <name>A0A8H5GYK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_000606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="682"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5373651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1961" mass="215048" checksum="17D304220FA527DB" modified="2022-01-19" version="1">MSSWFSSWLPEIPSINYFSLPSNIQRRFISFVLKRSLGHLLKPGQFEIQQIDSQIGSGHVQVNDLELDNQAINNLLSGLPFELVDGSIGSVTARIPWPNPLSSSLGFSLGSLHITLRLLPVDKSAPDYNVNLSDSVASYAESFIHDELNEEEASLKTSLRQELSSSHLDEGNLPGGLDPFVMHPEDSEASDLDPDGVSLFATLIERLLSKFEFDAADTKITVINPNSSRITITVGEISYRTRSKSTSNSPVEETGEIRTVSVSGFTIGASELYVPPISNSPTSLLHDSSVREHSPSASSSSSMDEETQWAMSQSLAFLPPRNASLSSSPESSMYQSALSSDHRHDQSGTFDSAASESTEQNRDDEGVGTGAEAGNEYGDAVFLSFGPDPVVIELATPSLRAASSTQTSSECLHLSVTTGFVGVAIRPWHLRVLMQLADVLSTSDSPPHLDQAEPSSPVGTRPVLPNLGKKLTVTVRGIALLLLPSSKEPVSLEKFFTRPSSSLFVQGDCVRLLVENISTSALLTTTSSPSRTISLSLSIGDISVFVFRAREQESQDEGKRLAFPIVITDSSLSTQYDSEHLHPEAEGECPDLPIIDVIDWTAERQQAYGAKISTWRARMKAGKTVTPPSNSVVVTMKQVSPVHGAKSTSVVVKVVPLHVFVDARQAFNNDDISAYTNALSSISSNQGHSQNASHSAEMDEDDDEDKAGDTPPATPRERGYRDGTRDQEMERKRLEKAVLEDLDLHYDYGVKDAAPKTKRSSQRNRTKKPRSSKTMEDEFKVEVKVAMIRAQIRCPLRDRDYSGAVVIDIHNISLAQGTTRADKNVSFRSSAIESSDGDVLASVEFSRLLLAVSAAKADKAQAFASIGPLVTASDKQQFTDTIQPLRPLLSLVQSRKSAKTSPPRITTNLAIPSVFLDLTKEALDSLQYWIDDISQLAQQSYDNDSDTEKAASRNSSLIGSRYFVQSHHGSGDASMLSAEVVPAANETVLKLQITEACIKVRLPRLSEGAAVIRPFDLLGSDIDILVELKPEGKDETVVTTSIMQLLARNHNTVGTVDTLLSLTAMRDLMHPKPLLKLRFTSSQIPQTTLKESRIHVSLWGFTYNFFPDIAWISDITAFVAAPPGAFENVVPSEKTRLSLMIMDGSLKATAPQHRGAMVLHMGDLKFSINLVGDSPDLAFTLSVPAAAILAIDNLSDMTATEGRISEGGHLYWKRSGFALLAEISNLVLRYSANKAPLLPDMRIMIDSLILRLHLCADTMTAISLFISDLVPVFSSPAEEQVPKPKRKPVVISEHESASTLMSSIDDLAFKRVPEIGPAPDMIFDDLPTNMDYLDESFGAAAGLREFVDDDLEDFPGEETEFASRNEEAQSPGVISKYGGETIRMLRPEPINIIEHHFDNLPPVAENGTSEFGETNLRVRIKDTDVYLFLYDGYDWTYTRKVIQEEVKEMRKKLAKIKQFVASGQTQEQAFEETSTLLFNSVYIGLEQGADELEPGALIAAIDEELKDDFETASQSSWQSLQPAASKPAATSTRLNGKRLTRSRGPSIEFRLHGINAQFDQYRSKTPLVSRVFATVKDMEILDHIKTSTWKMFLTSLRSDSRGNVRETGSDMVKIELRTLCPDDSSEEARLKAKILPLRLHVDQDALDFLKKFFSFKDPQAAPSSSDPDDGIYFQLAEIFPVDLKLDYKPRRVDYRALRDGRTIELMNFFHFDGAEMTLRHITLSGITGWPRLFDLLNDLWTPDVKATQLVDVISGVAPIRSVVNVGSGIADLVLLPIAQYKKDGRIVRGVQKGTTAFVKSTAIEAIKLGAQLATGTQVILEQAEGVLGTQFKQPITAETLNIPGDEDFAFSGPEFADDGAPISKYAEQPTNVREGIQSAYKTLQKNLNSAAQTILAVPMEVYERSGNEGPVHSVIRAVPIAVLKPMIGASEAVSKTLLGLHNSLDPNLRLDNDMKYKQRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H115</accession>
    <name>A0A8H5H115_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H115"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="534" mass="58857" checksum="935C2EE76AD2924A" modified="2022-01-19" version="1">MDSAETRTTKARRDAYKAKTALKQDDLRRRREEQQVEIRRQKREENISKRRNFLPSSGPDSDDEVISGNWDPPLAEEMISGVFSDDPERQLDATTKFRKLLSKERNPPIERVIECGVVPRFVEFLKTGHSMLQFEAAWALTNIASGTAEHTQVVINAQAVPEFINLLSSPVLDVREQAVWALGNIAGDSPQCRDYVLQQGALRPLLALLSEHHKLSMLRNATWTLSNFCRGKNPQPDWDLISPALTVLTKLIYSLDDEILIDACWAISYLSDGSNDKIQAVIESGVCRRLVDLLLHNSTSVQTPALRSVGNIVTGDDLQTQVVIASGALPALLSLLSSPKDGIRKEACWTISNITAGSPPQIQAVIDANIIPPLINILQHADFKTRKEACWAISNATSGGLQEPSQIRYLVTQGCIKPLCDLLTMMDNKIIQVALDGLDNILKVGEMDKNLAGPGAVNQYAVYVEAAGGMITIHNLQQHDNLEIYKKAFNIMDKYFPDEEEVDTAIDAANVDASGAFAFHSDVSAPQGGFSFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H145</accession>
    <name>A0A8H5H145_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdopterin synthase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H145"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17140" checksum="343986D077B59101" modified="2022-01-19" version="1">MSMLPPSASVEAKSEASGAICAISYTLDVPAIIRSVCDDGAGANVHFIGTTRNSFQGKVVTRLEYQAYSKLAVKTMMDIVQRAIESHSPAKCAVWHRIGVVPVGEPSIVVAVSAPHRKEAFSACEQILEEVKQKAQIWKREYYEGEDENAAQWKSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1A7</accession>
    <name>A0A8H5H1A7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1A7"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="323"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="883" mass="97958" checksum="D5E8DE814D0DDACA" modified="2022-01-19" version="1">MLPESISSPTSIHSFDFDPEPDLHPLYPSTPHIAVHLSSHSGLNPDQKAELVRHSLSRACVFAEISVLQYLSSDSQAQSYLDLSSRDDDGVGLVSLTIHGFGSDSERDVEREECVRLLVAQGADLGPDKAGWTPLHHAALLSPPSLISFLMTHGCSPFDVTRRNLTALDIVTAHSIMPGRADVALLLEEAMRGEGWTGGKMEQKRRQFDELMKRKGKQQVLREDVGRILGIPSRWWGSDSQNPFSDSDSEEDQDDDDGAIYTPPADYTSMLVFSPFALPGIFESLITNYPPSFRDAQPANVLYMLARFACLTCDHNWLEDFMLGATEAIEDCFFNHPEDITCLVFWLYNTTVWLHLMQCDNSISEACEMLGSLELIEETINSVFVFIIRLAERKIDEFLDAALLDYQSLGSEFESVQFESEWSFLRSLTGKKKNATVTPNSTLKAASSPTSHQPPSPGRAASPSLSASSSRGFSSFTSTFSRNRAGSSTTPLQSIFPDTPPPPSPNELTSYLTALHTLLTLSEINPALTTQLWSQVMYWTSCELFNRIITRKKYLCRSRAVQIGMNLSVLEEWVGQMGLPRGVQSHFAPVRDLLNWLQCLSSITEFSDLVATIQTMKNINPLQMRRAVRDYKYEVNEGRMTEECVQYLTQLQKDWERHRVKLGVEALRKEMGERERDREGSVSSFATDSADHSGQGSSISASSSSDVIAAQEAIDLLFDRGTDKSSWEPVQPPKVLGELLDSRYMLPLVFPSNPRMLGALPGNSLRDDDDKRSNASDSRSASRSSVGAMPWRAKNRKLRNLGSGALKWVDGAASASRWGRPVVEEEDGDPAGENGDPAGEDGEHPDKLQVDINFTPLTRKRSGKVKGRPSLQTGETTPVVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1R7</accession>
    <name>A0A8H5H1R7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1R7"/>
    <dbReference type="OrthoDB" id="3222453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5375147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="783" mass="85156" checksum="86CF9165FDEA2F74" modified="2022-01-19" version="1">MTIPNGPSKTGTPPVVVTDKDFAQHPIPLAHSDSSVYTRLLLPKGHGYPLWIPETDTDLPPEYRRYGIRIGDVGVVTDDGGFDYLFNICLPASDPVNKGRVPRDFKPLDASLDIRNNPTRFKPGADISSSYIKKTKKGDTQETSTYVFTPSCDEGAILVLPEGGARSDLKNHGEFRRFAAQHAAAWYRFINNELGWEITNGTLYLVTGVDKTSSWGNAAFSNAPHAVDVSMEFGLKSASEPSKGYVWTKDGSASVRYGPDSHGDSERSSNQSIFIRGFRVCVSATLYNDSLRKLNGEEAAYHPSTIINEFIFNKTTGVDIILVNDEQWPALLNENDTILPENEELIRRTFNKFNLIINKGVAHLELNNTKTEEADQSLLKPKLNITTSPTKHEPNGASNYHLKPASKSMVSPRSSSLGMSAAELLRLQQIAPIPSPTSYRQMASNDLVAKSPLRSRAVNASSPLVLSPTVRFAETYGGNSTDSSVTSSPQLDSRARIISPSNVLPNSAAQSVAPGGVPAMVNGNMEGQEEYGQQDFGTSLVMAHHRLQPQYLGPYYIVSPQMDGGFQSPATSSSVASQDTRYSNNRNPGLYKTELCRSWGEKGWCRYGAKCQFAHGQEDLKSAVRHPKYKTEICRTFWATGSCPYGNRCCFVHTDIPGQPGVIIDGNKANAAAANANASTNINNINNGNNDGEHLSRIAIRTQDLQGSIDSPSSAGANSSGVGTRQSLRIDTKSLDGPSVQNKSAFPSFTRNRDNLPVSSMIKSPAAVTAGVVWDDPSRRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1Y1</accession>
    <name>A0A8H5H1Y1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1Y1"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="581"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="686" mass="74137" checksum="B5625A80D62D9B7A" modified="2022-01-19" version="1">MNNVQLMVCDIMIMLVIEKPTKKNEPTQDGHLQLLLFESERAWSYAQDLLTLSLNQPPDASPSASSLRHHATGRFRRAIHWATQLLSTCQSLYTSSRLSALSLLEATIYTLILNGRFLRFRDDFDSALVQLSVARSLLDELADPLNAPTSRDQALASVFADEIGAEIRYCAHELGMERAWDVDSIVKDVGKKERAKLVDGVEEILKKYKEQVTESKGGHHQKEQRILEPLMWEGEPIPVRNPELVDVLLKVQQAEKKLDGAYDAILSALSDAEDVARRLAESQGSGGSGIPASNVGGAGPGASGGGTTRDVQFVHTYIVYQLLSRRIQRDLLLGSALISQAQVESESKSASTKSKTPSTGPGAATSQSKPTSGLKDANSKDVHPRILTATLKLLDTILQSLNQMRTLSIVDDNPDLAEAVDARVSWTRGRRCLNLAHCYASPPIRKYAEALTLIQHANLHLRETTSHLSLASQASSSGQGDGDDNADLTDLISSPPPNSGTIPFYALSQLEVRLLERELGRVGLRVKRDWFAWNGGVGQVTAADGSEESSKKQRTNKKKPPLFFNIALNYVELDMERLEERGGGKATMGAGTTTNTTKSSANTNTNTKTNTKPVEQTTTTMNTNPMKKSAALDHEDDMQSRSGTPEPSSASALGSGSGNQGAAATLRTGGAGGGLSSLLGGWWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIT5</accession>
    <name>A0A8H5LIT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Urease</fullName>
            <ecNumber evidence="3 11">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_008552</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIT5"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="400"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5358762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="840" mass="90514" checksum="8351AC2A45B19EB3" modified="2022-01-19" version="1">MRINPREQEKLLLHQAGFLAQKRLARGVKLNQTEAVALISSQLQEHIRDGKHSVAELMDYGKTLLGRRHVLPSVPNLLHEIQVEGTFVDGVYLVTVHSPICTESGNLEAALYGSFLPIPSDDLFPIEDESEYASEKMPGAIIPRKDSPRIVINKGRERIKLRVTNNGDRPIQIGSHYHFIETNSYLSFDRGKAYGKRLDIPSGTAVRFEPGDERTVTLVSISGAQIVSGGNGLATGVVDISRTESIVAALVQKGFGHTPQPGALEVKEDTDMGREAYISMFGPTTGDRVRLGDTALWIEVEHDETVYGDEVKFGGGKSIREGMGQATNRPASEALDLVITNALIVDWSGIYKADIGIKDGLITGLGKAGNPDVMSNVHPSLTIGSSTEVIAGENLIITAGCIDAHVHYICPQQVSEALAVGTTTMIGGGTGPSAGTNATTCTSSPFYMRHMLAATDGLAMNFGFTGKGNDSGPKAMEDIVEAGALGLKLHEDWGTTPEAIRNCLDVADKYDVQVNIHTDTLNESGFVETTIEAFGGRTIHTYHSEGAGGGHAPDIIVVCGQKNVLPSSTNPTRPYTNNTMDEHLDMLMVCHHLDKSIPEDLAFAESRIRAETVAAEDVLHDSGAISIISSDSQAMGRVGEVTSRTWRTASKMREFRGPLVSLGDQEGKDNARVKRYIAKYTINPAITHGISHLIGQVAVGTLADLVLWKPENFGSNPEMVLKSGVIVYSQMGDANASIPSVQPFYSKPMWGANPASAALNSVSFVSEVSISSGMIASYKLSKRFEAVKNCRNIGKKDMKWNDVTPKMSVDPESYEVRADGELADVGPATKLPLGRVYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTV3</accession>
    <name>A0A8H5LTV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_002730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTV3"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5369338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="54607" checksum="CAC5281729A636F8" modified="2022-01-19" version="1">MAAPSSPSVPSSDVPSTPQQPKVTRTVAIIKNHALSHRFDIEPRIQEASFEIVKERQMEFDVESDPDTLYELFGEDAESLGEGPVWVYVLERRRAVEVWYTLMGDRDPEVARENSPNSLRALYGLSRTRNAVMGSSDDEMAEIQIASLFASSPPFPTSDLPSTSDDGRFATMGSVSSSVLSALQKAGSDEGYACSNGGSTAGGSSKMNSSGRPSFRARGLPSTHDKPDIAPRMSRAAQLRANPIEKVIPRSGVVPIEKHSARAPISKERHTQTFSNVPGHKRSETIAVASTAAPTVAPRMTKAAALRLGIKPTPTTPRKTSSSSDSKVGTFEGVPGHKRRETIQVASVAAPIVAPKLNKSAALRATKDAAPPSSYMFRGPSQPKVPGLSRSNSTSSLSSIPHSRPPSARPPSVTGVSSRASSRPPATRNTSTASGTNGSAKASPPTTSPTQEAPARPKPRPSSISAPTIAPRTNKSAVLRAAKKEQEAQAAVEAQRRARRASARPPPSSMHTGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUK5</accession>
    <name>A0A8H5LUK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUK5"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000023">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="77" mass="8531" checksum="A31B90B3CD22A928" modified="2022-01-19" version="1">MSKASQPELKKFMDKKLFVHLQGGRKVSGTLRGYDLFLNLVIDNALEETTPAQKHPIGTVVIRGSSVTSMEVMEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXD2</accession>
    <name>A0A8H5LXD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXD2"/>
    <dbReference type="OrthoDB" id="2383679at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="23240" checksum="051E54073AB88A39" modified="2022-01-19" version="1">MPSDLNQKLFLGKLPEGLKFTITEVTPWAEGGGTFGQWGAVFYTANGVSLSNYGGKVYGHLDLPLEVDVSKDVVKLGGTKLVAQNGVYVSGQGGKIDIKYHIEGTTMVDGESIEICGDGFISVSASDWGGFARPDYSNVTYTWAGEPPVNASLGVPSTIAGMPDDIYIVFAINPKENKLGVTTTTHRDLVSTIIDYALKGVFWANSKLFGWAIGKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYJ3</accession>
    <name>A0A8H5LYJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYJ3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5374243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="178" mass="19695" checksum="7050D30FEE8B8F4F" modified="2022-01-19" version="1">MSLYYVTNAPHPQTRMGYPQISLYRSEFCSYRDGFHRSSNIGFPPEAVGNVTNFILVSPNILTPTSLINLNLLSSEFDVFALREGVKAVQRLLATTPFQGFILQSTTNATTDEEIDQFVRETIIAGLHPVGSAAMSQKGVDWGVVDPDLKLKGARGVRVVDASVLVRRRFGIFLESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYL1</accession>
    <name>A0A8H5LYL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYL1"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5374795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="28438" checksum="8C414E7098E99D4E" modified="2022-01-19" version="1">MDDIPSLSNRPVGSRFVTQDEVESARARREEQWKAAYARLGQEPPPPQQEDAFDGRSLAEIAKQEEWEEKTKLGTSKIPLYLFPYLKLSSANQFRALEEDEIMFLDSLREKQEAEERERRQKDGEEVQSFKQYILFFISTTLSLILLHRAVAARIQTTNAPPASTASKAPPPKPAAVKKDKKPLKGVVVKRKAKSSDNKLETKDAVEKKDAADKQPATSKKDAADKQAATSRKADELDKDEAPASKRRKVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZB3</accession>
    <name>A0A8H5LZB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZB3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="279"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5374916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="475" mass="53430" checksum="0EDF33C1C0FBCA82" modified="2022-01-19" version="1">MPPMAQSTSSQDKQKKPRHRHSPAQLAALNELYERDEHPALELRVSLADRLGMETKTVNAWFQNKRASSKKRTMSRPNASYDIPSIPHTTSSLSRPTDMDDFDDDYSSVDYQNPHRSHSPAPSSNGRAWSTFYPGNPEHTQFLNESDNVPRRIRIRPTNEQIEELRKLFNITHHPSTEQRQALAERIGMRYQSITNWFQNQRSTAKKRDGDSITPPEESRTYSAFPPPAPPSLAPRTSHASVGLGRSRRSLSPAPREDLSISRRSLRRSSTPYGSLMESRPRRTRPEQYQLKALNQLYAKTSHPSIEERSALAQEIGMDLGKVTNWFRNVRQTRKRNKKASAASGDEYEDDYHVYSASGSRSDTPSIRSSSPSVNDDIMMDYEDAVLPSGGSISDEGSDDEYEEAVTPSSHRSPSPAPLNKTFGGLNGLPVQRVTLTALSLAAIDLAEMEKESVRSGIKVEDAMLLLTFHQQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ATL0</accession>
    <name>A0A8H5ATL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000595">
        <property type="protein sequence ID" value="KAF5310298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ATL0"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="499"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5310298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="679" mass="74107" checksum="20EE83E105D41704" modified="2022-01-19" version="1">MPPQGPDSSTSGAISDHPGFQLHIHSDMAPLLMPTSHSSSEVSGRFGEERATAASSSSPSTASPVTPIAHPPSFHPHDGGRPPGYFQYAPQTEEGHRRRSNSVHMESASYSHFSSVPKAGKQNKDFANNTPAESLFYRAEVPPAIRITLQPVDASQHGVEAHLTSEPFQSGQKDLPAQTLPSNLPPSHFVATMSTHPIEDDVPNFSGLKISERLTESPVSVFSSSNSSAMPSPVLNQDSSTTQSRTASSRSREREVRFDSPVPSTIPGVTAPYGAQGLWGDSGPEPPPSWPRAFSCSSGRLNIDGTPHHVDQQHHGIYAHDTTAWPLAFQHTGRSSNESTLFTSLVLPPTNPHPFPNMSLPLAVQLRQLLSRPHTPHHPHHVLNEPPVIPNVVVDSPRSGSTVPNETAHLPALPLPWVPLRAGDPPHFNLPPRIHPSPGAHGPTPTPYHCPDGSVPNSPPSYVTAATTGTYPAYNVNGNVFNQNSISNVPPGKYYFEDGNVMFSVKNQRIYRVHRYLFLTKSTVLPAKMYSYHPTTPILLDDVEPKDFELLLSILYPETPGKLGIEGVEEWSAILRVAKLYEMKSIERLALDEILNIASPVERIVIAREQGVSDWLVGAFTELCLSKDPLTDQEKSLLGMQTTLMADSMKQGIMDKLEDYLDMQKVRSMITNVLKESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AUM9</accession>
    <name>A0A8H5AUM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_018812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000554">
        <property type="protein sequence ID" value="KAF5311390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AUM9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="71"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5311390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="480" mass="51304" checksum="C1A4784C9CF947E0" modified="2022-01-19" version="1">MSESELKKGSAAATAQPPDNEVAPVPQVHFQKQVQEQVQEIPVLKKLAGESGSKAWKDEAHVLPKNNLPIVFLGFMCTVFLAAMDQTIVATALPTIVSDLGGGKDYSWVGSAYLLAAATISPLYGKLSNIIGRKPILYTCIVIFLIGSALCGAAQTMVWLIVCRAVQGIGGGGIMQMIQIIISDIVPLEDRGKFGGFMGATWGIASVVGPLLGGVLTDRVSWRWCFWINLPTGGAAFALLFLFLNVSPGATKSFSEHAREFDFIGLVLIVTGVICLLIGFNYSENTWSSTQTIVLVAMGASLLILSGVYEASTKKSAIIPRRLFRTRTTAVLMITTFFHAATFFPGAYYLPVYYQVLGASATGAGVRMIPFSCGAAVFSAISGIIVTKTREYRMIMWFAWGIFTLGYGLMIMLDSHSNIAEKVLYPLVAALGVGALFQTPLIALQAAMPLKDVATSTAAFGFLRTLGGTVGISIGQAVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AVY5</accession>
    <name>A0A8H5AVY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000547">
        <property type="protein sequence ID" value="KAF5311543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AVY5"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034431541" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5311543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="52864" checksum="81E182DB6D913D23" modified="2022-01-19" version="1">MTLLAKFQLLVLALTSGLAVADFRSDLTGTNTLFPNSDGYASASQAYNRRFSRQPAAIAFPSTPQDVSAIVQAGAANGMKVVARGGGHSYIANGLGGENGTLVIDMSNMKAINIDSSANTVEIQTGNRLGDVATALNSAGRALPHGTCPYVGIGGHSAFGGYGFTSRQWGLALDPIYAIHAVFANGSTVTATDSTNSDLFWALRGAAPSFAITTSIELHTFPVPSHAIGFSYSWELDATAAGQAFLAYQNYSLSGPPSVMGSELNIGPGSSRGSISVSLVGGWYADESSNDGLDAALQPFLSQMPEPSSSEKLGNGTYIDSVVQFGGSLDTSAEPDTTDTFYAKSLMTTTGSPVSADAFNAFAKFLSEDGFDSETSWFMQIEQYGGPNSAINSVPSASTAFFRRDVLFTWQLYASSSNSQPPYPEDGFTFIDNVVKSVTDNMPADWDYGAYTNYPDDRLENWQQRYYGSNYDRLQQIKREVDPNNVFEFPQSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6D6</accession>
    <name>A0A8H5B6D6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_018911</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="JAACJM010000472">
        <property type="protein sequence ID" value="KAF5317629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6D6"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="316"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5317629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="839" mass="93137" checksum="AE5D9C558526E26E" modified="2022-01-19" version="1">MPNDVPTTAPASGIQPPLAKPTLPCPSHPLDPLTPDETTAVTLSIRHHVASNPDLGVKALRFITCYLVPPPKRAVLEVLGIGEEKNAKVEIVRRAEADFLDIVTGNNYNVYCSLSSSPNGPTWTVDTLTLLPSGVQPQISVEELIAAERIVKNSPKVIELAAEVGVKPDQIFCDGWSIGFDERFPQARRIQQALVFARWGENENLYAHPMDFIPIIDANVEQVLHIDFPPRWYRSSQPKSTHPLDNLTLSTSTTGLLPPLPDSLDEVTSEKACKGISGRERIPPPMRRYDFLDDELKGHADENEKPYKPRTDLKPIQILQPDGVSFKLDGHVLEWQGWKMHVAFSHREGIVLSTITYKDYITEQVRPLFYRLSLVEMVVPYASPEFPHPRKFAFDSGEYGMGTMANELSLGCDCVGKIAYLPGTYTSHSGAPVVIKNAICIHEEDSGVLWKHSDYRFFGQGDRETAGGKTVRRRRLVVSMVCTLANYEYIWNYFFYQDGTIEIECRLTGILQVYVAAPDEPNVFGTTVAPGVNAQNHQHLFSFRLDPMIDGLNNALIESDVWPLDDYLEAHPPPSNSNSTNSSPGQHSLTPNEINHFSNAFLSIDTPISVPSPRPYSLPHDRRWRIVNPSKKHYASGKSVGYGLGVKGSVGPVFVKRGKEGKEGKGEGWVMKRAGFIEYPCWVVKEKEGESVVSSVDNEGEGEGEVKKVKGEGSQRMWPAGKYVPQTRENPEDSIGRWVVDKDDDKDGEKEKLDTEKGEDILVFLTIGTTHIPRPEDWPVMPAETLHIHLKPQHFFDMNPAMDVPGTRDLMSKDAFSTHGSDGVNGTNGTNANGACGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BGW7</accession>
    <name>A0A8H5BGW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_018057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000397">
        <property type="protein sequence ID" value="KAF5323180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BGW7"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5323180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="297" mass="32415" checksum="2E3DB25042E731CF" modified="2022-01-19" version="1">MGREHVGKGVNVALGPMMNMDRVAQGGRNWEGFGADPFLAGEAAYETVLGMQQAGITACAKHFMFNKQEHKRTTTSSFVDSEPHMRFMGTHAINSTYACKNSPTINALLKSEYGFRGYMMSVWQATLSTFGSVAGGLDMTMPGDITFDSGDSYFGVNLTEYVRNVTIPEERVDDMATRILAAWYLAHQDSPSYPSTNFNAFNIPDEATNERVNVQADHYKIVRKIGCAGIVLLKNEKPKQKFPHTNTDLDRPALPLTGRERAVLVAGLDAAPQRGGPNMFSDQGGNEGILAMGWGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BSV6</accession>
    <name>A0A8H5BSV6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000363">
        <property type="protein sequence ID" value="KAF5328456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BSV6"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5328456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="23304" checksum="AE830E87778784DA" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKFTGRKIDANALIDSGAEGIIINGQFARKHQLTLLPIKNPFPVQNVDGSENTMGWVREYTIQNLRIYSRDGVAYHEEKAKFYVTDIGDHDIILSTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKSLKPTVIDPRTHHKDYQVRWLEPVGQFKPVAQPKIAGRRRRTPIRSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BY40</accession>
    <name>A0A8H5BY40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BY40"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23950" checksum="6688C744C6315774" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFARRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDNKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKTLKPAVIDPRTHHKEYQDDDVEFLFDLSTETQKKPQSLPKMTTGGTRSQNCGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4K3</accession>
    <name>A0A8H5C4K3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000260">
        <property type="protein sequence ID" value="KAF5334426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4K3"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="769" mass="85233" checksum="4D1E138D85701F44" modified="2022-01-19" version="1">MLNIMGALLSRIWTRQDRYREFITLAGHRDAILSLSFSLDARFLAVVGLHGIAMYKMSSSPPGGEVTIPHVSTNPQDPKNLFTASAWLLFQNGSRHIVVVGNMNGDVVLWEWRTDHKCFETFIKIPAQASRDGDRPQAPDGQVMFLDVYERIVPDHHHGRIAASFSSRVVTVWSVSIASKEVTEVFRVSLKDSFIPVTVKFLSKLDLLVFKAKSGDICILDQKTGATKGRHIVAGEFLGQVCFNDRQDAFLVWTGKSFEMFSLENRQLLRVFGGNTSQSHLPRQVQFIEEGRLVLGGAETGCALLYDRDSGKLVQSLPLSSRKVQTVTDQASASSKHYFVAIAGSTISESNKVKVFFKLRPTPKVPKAAVICLDDDWTLHMKLPWFFHAFYVACAVLGMAVLCIGLVLLAPIPETVYWLALWLYNLVQQGDTAPVAWTSRQDVVAPWIVVTPPVHFDGGKMAAQGVMGQEVSVVYDGSICVPPECITMGADSLRRTMKEMVISFFRLAVIAPLALAGMVSFAKGTVTLEDLKDIGEELKVITRRIAGYLVLKTPDFLRFTAGFIFTWLMFSAMLAAMAAKYKNYYETCHGREPICISLKISPLSSLNFWHSIIGPLLHCFPSSRAQTHGGNSAHAAAFFAGVSGGIDFSGLFPSTSTLDGSFAMFLSPAAGLMATDYVVIRRRRLRLRTSGINFHAVIAWVNGVWPLMPRFIAAVQNETTSKGWMVTYYLAWLFGFFVSIPSDIFLAMFADLKDSFARDYFGFSLVLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C683</accession>
    <name>A0A8H5C683_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000234">
        <property type="protein sequence ID" value="KAF5335886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C683"/>
    <dbReference type="OrthoDB" id="2688393at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48772" checksum="D5B3B656C556B720" modified="2022-01-19" version="1">MTKPYEHIALMQYCWNSDNTNFAEPDSDVEPPPTTEHNSSSYNSNKADKLDFGPGNFNVLEFGYISDRDQDADDGNSNITSTHGRKCASVEDIEDDTSNDPKSIYTYASDDLYIEPFPGLAGSPLNAEPVLMRFEEMLEKQRLDGKEPWYLFASEKEWELAHLLLKSGVSRKKIDRYSKLESGIVYVLNTLRPGEIQIVSSPSPISAPTGTTGGTTATAAAAGEATPSDTGSDAPSAHFIAAASSSVADWDKDNNKAMGVIKLRVAQAIGVKIENITTTRIMWDTLKNLYGRPGAAEIFQNFKRAMNVEISRNTHPGTAIDLIKMYLTCINNAGDNTEIPMYLQYMIVINKLPPDIYAYIIAKITQDDVDDFEDETLDNLRTHVVNTWEARGRKKPQSANATKITAIKRKGKPPVFEEQQQQCHKGGSSAWRGKGCGHGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6M3</accession>
    <name>A0A8H5C6M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6M3"/>
    <dbReference type="OrthoDB" id="2741288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="70738" checksum="0AC43D3CC5DCE663" modified="2022-01-19" version="1">MSSNVLMTTVPVFSGVDFNIWADILLSWLQATGLSSVLGSDRPSDATVSSVSPLSAEDMAAQAEAITVALKKQANWDEKNDKAIGSIKLRLSPAIRQKTLGMTSAKEIWATLKNTYGKPGVSTVYTDFKRATSITIPNDANPSATIELIRMHFDRVSAAGISTDTTDSTTPTASITKIPNFLQVMFIISKLPPRYEYIVNQYTQLSISQIDNQDLDELQSEIANVWESRQGALKGKPQANRLSAVKRKDGNPSFQQQQQQHPSGSSSGANGDNKGKGKGKGKGKAHFRQGGRAGKNEQAKRQGQAHLVHGDMSPMMHTVTFVDTPAAVDSRKPFFMETEKPFDAFFTGTKRAINLARNIGARPSGETVAALEDVVMSNPDPSSFTPLTPAPRPKRTLTECIYWNNLQSSSDGWECNDNWNDAFTRSIGTQTDSDADMGCAQEEDASWNEDTLVNTSELGSVFGSTMMESGVKVPQDTRTPVPLIDCLALDPAAEIMECGIHLGERFQNPEDPLHIYGEGATPFQAVVNAYASTGTLSLVQHLAAVRSEMQSGSLPAHPSGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLENEDGRYDELLDWQKDTTVGLGGMEMEEELPSRVLTPSSMPELRSMSPSLSSTSNLEYMSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG40</accession>
    <name>A0A8H5CG40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG40"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5339907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="266" mass="30665" checksum="4599B5E760E841DC" modified="2022-01-19" version="1">MSSNNAINNAESIFNVPILNTTNYEFWNYAITRLLEAKGLSRVASVSNEVFNALTESKQLSYNQIIDTFAHEWDQYQILVNKHDWELVETYKLHSSWDDKDEQALGFISSYLPNDVGLEMREFTRDEIEEDPCAKAKGDYTAKMLWDKIDKKYSSPGPTSWFLDFKEFMSWTLDEKKDPANQITSLGAVLTRLKAYGFTVDDKFRALFLMDRILQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKRRTGQSSVSSLLTRITGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJU7</accession>
    <name>A0A8H5CJU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJU7"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034302992" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="65389" checksum="BEE22A9A6757E0DB" modified="2022-01-19" version="1">MALSRSLFLACFFFFKASAQGFTSVTPQQWAALNSSVDGRLYVSVPIAQPCFDQLTGIVSGDTLAPNADKCSQIQSTWSNTTFRVQQFGAYEQTFSERLHGANCDLNALDPTDPEATTTPCSIGSIPPYHIDVRTAADIQAALKFVNKTNVPLVVKGTGHDYLGRSSAPNSLALWTKNLLNQTFHEDFVPEGCNESVGRALTNGAGVTWIQAYEGQSSFVVDARSRQLTVHGIVADANNATIVGGAFQSVGASGGWHMGGGHSFMSGKHGVGADTILQYKIVTADGKLRVANKCQNQDLFWALRGGGSGFGVSLESTIAAYPAYDIKVAIVQIQNITVDAQFEVFRVFARLRQRLANEGWGGAFLPEFTPGTMAISMVNPTLSDEEALDTFSPVIDYVNSINGTDGILVAVNGFQPSGNYLFVQRNYIATVPVGLGAFIGSRLLPMSSFTSGEETLDELIVAMKAGLKKVGPGVWPPMEILMDTPLLTPDTKKETSVHPAWRSSAFVMVWGVSYSHNTTAQEEKALMTNLHDALDIVRKVTPGSAEYVNEADILADNSSEVFWGPNYPALLAIKRKYDPHNVLTGWQYVGFDRRNPMFDRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK62</accession>
    <name>A0A8H5CK62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK62"/>
    <dbReference type="OrthoDB" id="3229610at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034229049" evidence="3">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="31063" checksum="12024BC70025526A" modified="2022-01-19" version="1">MRRVRKASLLSTVLFTLFWPSLYGWKVSVCKNDDYGSSLETTPYEFCDAGKVAGALEIVADAASCVCLILTGAYILWHMKLHSKERQILIFMFSGTIFTAMAALARSYSILSTEDMLQAFTSHFEAAISLIVCNVVVVMAGIYGMLYQSRDSSEPTTDVERSPNEKGLHQVDRITRDTDSNTGRPSTLTFTEVDSFESPHSQAIHSDPSHSFSSHTRSESPSPTSVHSVSRSSERQHRSRAEDPNPQTSTSSQEYYTESEPCSGSVIIILDTDSSRSELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKC4</accession>
    <name>A0A8H5CKC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000143">
        <property type="protein sequence ID" value="KAF5343305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKC4"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="66728" checksum="5393E90E0BB91FD9" modified="2022-01-19" version="1">MKDPQGPLPPDVIGIVMDYMPRRTPSDLVPVIQLSNMCRDWRLVAVTTPSLWTNIRVPIKACSLQERNNYHSVAWTILSRSGCLPIDLLIEGDGGLYADDVKSTVEALGLEMENFYDRKDLYDTIIDRAAEFIEFLLLFSEGYTAPQEEQAKSLDFKSRFKSLALRVPLCVAYRGFSHLKPASYFPILQEISFRTEMRWGGARSGDDHFYLFRKIFRREQQFYFHSKPSLSTSLYPYLPCGQYPYMPVSLPILFTNSPALQSLTLQNKSTPWFSIINHEEFLGFPPWKTLKHLTINEVTTAVQLRAILLECVALETFRATIPYPGSAIDTMEDNLPPAHCLQQLSILRWDIPVHYYCDGGVLFDHLLLPSLTDLGLDGVVRPAGSLIRLREKEQVYLGSRFQLTRLLLYRCIGIVLDELCAFLSECEALEVLALKDVETQGELYDEFEFESEGCRDLWMESSFLGLLRGGLPRLHTLTLRGDLCGEVVEDGYPSRKHAHQQFAEAIQFREKAAHLPNWNRFNLLYNMCYDPKQVWLTPKAEHIYWALVLDGVNINIRYPFRNPISQLHAAEVGDDDFKNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKH2</accession>
    <name>A0A8H5CKH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKH2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="65"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5343442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39314" checksum="C57292EC1AB9CACE" modified="2022-01-19" version="1">MSIPDNRNFKADKSMTGTANNGKRLILDGPPPDLPASYRCIFSVTLKMSAAPKIKLNNGMEIPAIGLGTWQSKPEEVVAAVSHALKEGYRHIDCAWGYGNEKDVGEGIRQSGIPRSDIWITSKLWGTYHSRVEECLDQTLSNLGTDYLDLYLIHWPVPLNPNGNHPVFPTLPNGKRDVDHSWKLSDTWKQMEEMVTKGKVKAIGISNFSVKKMEEILPTATIIPATNQLELHPYNPQHELLAYLKDKGIVPQAYSPLGSTGSPLLKDEVILGIAQEHSIEAADVVLGWLVAKHIIALPKSVTPTRITANLNGAIAGSSKLDKDDIAKIDGLAAAGKQKRFIMPPWPVDLGFDNWPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL04</accession>
    <name>A0A8H5CL04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL04"/>
    <dbReference type="OrthoDB" id="2369050at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="619" mass="68682" checksum="C8EA448ADEC98AD8" modified="2022-01-19" version="1">MNFFSVKRDELHEGSAADFENIVCSHVLGVKWKENTERLITGANLAKFRDEDFSLMFNTLMAYNKLLDGTSRHMSDSSLLVALRTAIERVPGAGLRDYLEEKKVLDVEAGQDLKKWVEVITIHDAEYRKFKKPERDRLERLEKALRAASYSNQSSSSSSRNTDSSSNSRDQYRSSRAPAPAVGAVFPTNRAPYMSEVRALAGQIDLYKAMHMCFSCRVANADHKGSNCPNKAVTPPLTVPNRPLTQDDVDYVTKIWREHNKPVSLNAILKRRTAPAVAAVGMASGVIDDLDAFLEDVRGRSHPVSAVFPSARNVSDTDLYSNAHVRRRSSSWPSPMHVPGRRGRGSAHYDDYANSPSPDNRRRRYSPSPRRRHRSPSSSPSRASPVAALNHVDDEEDVNWVENDGPTTPRGQKAAAGLRNTVVSEAPLRLPHLNLHAALEGPATSSPLHVSLLLDSGSHIVLIRDDLVVSLGLRRFRLPRPELIGVATTDSSSQSRTIALHEFVKLRITDHSNTWTSRTVQAIIAPSLCSPMILGLPFLSHNNLSINCTDRTCIDSVTGIDILDAKASAACLLSSKPPPDSRSPKQKRIEICKLRIALIRELKSFHDRNPRLRDSDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMD3</accession>
    <name>A0A8H5CMD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMD3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034203297" evidence="1">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="239" mass="26046" checksum="DAC3105B3D8F48DD" modified="2022-01-19" version="1">MKNLLPLVIVALTNLVAAAPSRRQEQSDFFSTEYAVENPTPINGFEFCEDEDCDNGTWKALFSGHINSVCNDIPGLPLPTTVGYRRTGDDSTSAIYKCDDSIQPLIYHRTVNGDIDLGVFWRLDVSQQWPTSATKRDFSQVKFPSGTFSVINSECDFGQNITITTIDAAGVTNTIEGVDDLRTEVPKALPANVTVVVNGGDSHAEFFITGEQRLLVEFGGDNGPSLSAGYDLQLQLCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMY5</accession>
    <name>A0A8H5CMY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMY5"/>
    <dbReference type="OrthoDB" id="3226942at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="81142" checksum="9FC2177C3149FB02" modified="2022-01-19" version="1">MGVQFWVMLVIKNDSLNKIAHYGGGGIGGSGSEEAKKGRVVLGDDIQDVSYIRSCSDTTDTVREEALEFLKDRSSTVARPRNKKRKGEEGPLDTFFDRSLTAREEEEAEKLLLRGWVSSNHTFLSVGDPYFLKFLHFLHPSYSLPTPYVLRTCIFDSEAAQVKKEEMDELKGHMNMTLLIDGWEDLLKCSIYGTVASQVDQEPVVLALNDLTGKRASADGVYECALSSLNSMGLGDGRNFIAVTTDNPTTMISFRNKFERKFPWVITLPCFLHQLNTTIGEICLYPAMKTTISRSTRIVTFFNGSHYWGGQLKEEAARQGITRGFTKNCESRWYALVLHCCSVKGYRYPLVTICCRPDANEKENGFSCIKAEVIEIVQATTTFWKQLDQLIRVTKLLVDAIGNLESREANLADCMLEMIRCARFISEMKLEQGDDADFLDNAKTVLNKRFRRMNTPIHSLALFLHPLCQKLAISDEAGGRDLQFMISAALKLASKWKWSACDAKALVENIKDYNLCKAPFIGGMKDGKAYWESLSVASDQLPLKKLAITIFLIVPSSSDVKQLFSDLGGIQVPKQNNLNINTFEDLGKMRCNLRQHHHSELRAQGKSIRCKHGHMHTKTSPGINTAIVEEGSVTESDNWQGLLEVDEEQVEEEDVEASFDSLEKEIEVEKDIELKLELEEELATLDIVEGKLYDFSDFMSSKRWTRGWSLRASMTRLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNL6</accession>
    <name>A0A8H5CNL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNL6"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="652" mass="70800" checksum="9CFFC7209DF3E6B0" modified="2022-01-19" version="1">MAHIIKKMSSNILMTTVPVFAGVDFNIWADILVAWLQATGLSSVLRSDRPDDAEVSTASPLSAEDAAAQSEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLGMTTAKEIWDFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAYGIPTDGTSTTSVTKVANFLIVMFIISKLPPRYEYLINQYTQYTLEEVDNANLDVLQSEIGKGKANFRRGGRAGKSEQAKRQGQAHLAHGDMSPMMHTVTVVDTPAAVDIRKPFFMETEKPFDAFFTGTKRAINLARDIGARPSGETVATLEDVVMSHSDPSFTPLTPAPRSKRTLTERIYWNNLQSSTDGWGDAGNWNGWNGEYPETQTGSDADMACAQGEDASWNEDTLVNTSELGSVFGTTTTESGAKVSQDIRTPVPLIDRIAADPAAEMMKCAIHLGERFQNPEDPLHIYGEPLRATLNTVAPTGTSGTLSLVQRLAAVRSEMPSGSRPAPPNGMITQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGGMELPSRAPTPSSMPELRSMSPSLSETSDLEYMSTPPSIDGMSLPTSPVEETASYGIPSPRPSTPVMVTVNAANNYGWSLDSEPSGLDNGYLRSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRK6</accession>
    <name>A0A8H5CRK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRK6"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="229" mass="26001" checksum="24E3836FA82580D9" modified="2022-01-19" version="1">MAEFTTPKWRDHLFSVVIVGAGPAGMMLAFCLAKMGVNPLIIDNALASEHEWGRGDGMQFRTLEVLRNLGLYDDLEKQSLKVATMSQWAITENPTVRHVTNFAAGDMDIEEKYGLTIRQGIIEKILDKGFEELSPGNKVHRPWSFQDAWIEDRSDPNSLVNVTLRSQYGETRQIRTRYLVGCDGGKSQVRRTLRDRYGVMFEGSPHDSAWGAVDILEPRTNFPDIKRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTI9</accession>
    <name>A0A8H5CTI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTI9"/>
    <dbReference type="OrthoDB" id="2754059at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="19852" checksum="90C946A5BED1BA0C" modified="2022-01-19" version="1">MKGTDISSYNSIFDTYREESEFGEAALLEFYQDGLPPKLREAVGRTYPKWDGFEEYKERAVELHLEWLKERERQGRWKTTSTSKSAPGPSQGRTVASVNVLMGPGANPSFNLPPKLTPDERDRLQKAGACFACRQTGHMSNECPTFPRKSFQNTSRTFPLMLFEQPKPHLHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVX2</accession>
    <name>A0A8H5CVX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVX2"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5348076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="14335" checksum="1CA0DE22FDE32ABC" modified="2022-01-19" version="1">MAETVWGVIDRLGKVSRPGTANLHESRSSISLSANMQFKILTISALATLAAATGTPAPASQCNTGNLQCCNSVQSSNTGLVSSLLGLLGVVLGSVDAQVGVTCSPISVIGVGGNSCTAQPVCCENNTFNGIVALGCSPVNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVZ3</accession>
    <name>A0A8H5CVZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVZ3"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73569" checksum="4C86BDFBCA51BF8D" modified="2022-01-19" version="1">MADPSSNAASFFPHSHGFNYINSNVYNVVGNMDVVHNHSDQGRGRLFSNISEVIPWSTESPRVVSQNNIELLDQLASRKHYYIHSGKYEQRFVLVKVFRGIEAKENFKEEKKQIQRLFHPSLLKMIGVSSFAAERPFIIYNFDILLLGYKIVSELANGLDYLAEEGAQARSNDNNSIEIFITDEDVLKIAPDFGSLQNSNTRCESGQIDEDSLWVLFNKLCVKTFREATYILHQDLRSRNKSYSIAEMSATDNQSFIPYNTSTSNFSERSAIYRRELLWRESEHGSRSVAAVARCYRQLWEHLNLTVGQSYPSYAMPRKQAARPLRIVVHRCQGYRKEEITLTSDISKNAIVSHSIPSLHEICPVCKEIVEEEEFRCACDGNDDGISPTIKSPNPRNPDEDANEGTGMPLSVSSRQKPYIAQNATPSPVNPLLLPNNGAKVCVECVMRDQDVADVDVTSPGIWDRENDVYYEDLRWKEEEQERSGIVDTEGLPRPRYKGGLLTEQNLKIWLSSNPREPASTRQQTLSEYVMAQRVLLEAESVARARAMQEARQLDDRMRDTFSQLWRSPYDMGSSAAPTDSSRDVRIKPPASPASPLIGGHERSQSRGITLKLPFWRMGMSMYGKRSARHANASARRRDERENLPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZT3</accession>
    <name>A0A8H5CZT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034138050" description="Xylanolytic transcriptional activator regulatory domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5350409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1535" mass="171729" checksum="94FFAB02B1F43CA6" modified="2022-01-19" version="1">MVVGSSVASSLLICALSSFPVRAQAGNALDFVNLFIGSVNGGHTFPGATVPHGMVKVGMDTDSPGNHAGYDGDPQYNVTGFSQLHQAGTGGAVPLSNFKLFPILNCTKFEQCLTTMESRKVKRNILPDGSPDDFAIPGYFSTNLSNSIRVELAATRRVALHKYTFPSGTTTPRIVVDVTNDGQLSGINPELSIDPDTGRVLASGNYAVSFGPGRYDAFACVDFKGFGYSFDVPIEYGPYKINYPDLWGTDLQQHYYSWGSEHGGLIGFPSNPDSSDGTTTILARVGISLISTEQACANAESEEIADWDFDRVVKDSQEQWLDILNRVRVNADGVDENVTTLLYSSLYRTHLAPADYTGENPGWDSTEPYYDAFYCNWDSYRTLFPLMSLHDPANFARIVRGMIDIQKNEGWLPECREMGQKQFIEGGSHGDPILAEFLVKFQDHAEALGVSAEELYAALVADAENTPKNWNIQGRQADVWKEKGYIPSDTTYRGGANTKQVSRSIEYAFDDFTISQVAKLLGKTEDAAKYTSRAGNFINSWNPNITVPDSSLSISGFFQPRFANGTWNYTDPRHCSVNDPLQATCFLNAIRRDGFYESSPIVYVPQDTAKLIELQGGKDSFIERLDWIFDENYFDSTNEPSQQIPFMYHYADRPGLSTRRARMTIETFFNTSVNGLPGNDDSGAMASYVFFYLAGLYPLPATKQFLLSSPYFPSISFYNPLLNTTTTIKSNNFTGNPGLADLEDASGLTVRNIFVKRTSEIRFYSKPRGTKSISTIVKSILSADTQFDLPDSQEAILQMLVDMASHVAALEEELAKYRSNGFTADEPQETEFQASGLMGSSSLGSTRSFPSDLHADTSVASRSDTVGGVSESFERLGLEHSRHFGASSSLTLLQTAMDMKERLPQDVMLPSSLSYRSLRRRRPEFWAIYPWQIPIDSHAPALVFPEESLTHDLINLYFLHHDRFVPVLHRPTFETSVSEGLHHRNRQFAYTLLAVCAVAARYSNDPRVFPEGSTQEFSAGWHWFRQIQLFRNSYISPPSIYELQLCIISILFLQGTSTPEACWILVSYGIRLAQDVGAHRRKAGGQESTVENELWKRAFWMLYVMDIYISAYSGRPRATSGDDLDLDFPIECDDEYWENPNPDLAFKQPLGRPATMTYCIVLLKLFDILSTAQRTLYSTRRSDIWTMMGMSNSECNQKILSELDTSLRNWIDSVPEHLKWDPNREDVDFFHQSVLLYVSYYWVQILVHKPFITPPGTTSDLSFHSLAICVNAARSAIHVMEVQQRRGFLPLPNVLVRSKFNLSVETLRVDAKRTSQVTLYNAAIVLVLNSWRGKHFKTSAATNSELIEVYKCIGMIRYYERRWQNSGTYSYGLYRALWNPGILRYVVFRDVICEIIAISGLDQKPQLPEPSRKSSQPHSQTQDSAMAPSDSSVMYPIFADATSIPAENIDIDPLFNLPLHSNELGDLPLHESFDPFGDAARYSNIPMNGLEIPSLGLENLSSSSNTLPTELLDGHIDELIGGLCQPRTCRLFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2C0</accession>
    <name>A0A8H5D2C0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2C0"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5352281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="62355" checksum="F3095730510A35FC" modified="2022-01-19" version="1">MNSNDTDTDTNDLPIAFIRGFVFCSEHGSEFCSKCMMDQRLNNNQNIMGALKKAFPDKKGDFADRPPIATAFSICTRSKTHKSPMFGDFLFECNPHKVPECPACFDWEKIVISQMKLVYSSKNPNAIPVVLSRDDKLGLLASMGVDLPPKTRLPDLDLERRLEKGIDKAQGFEKLIGEGHGNRKAYDPSRLSKWPSSKSLLNGMTTSSLAEALHNAAKGSREPELYKNPFTDTRQSLMGLGNAWDHKPRMSCHIFEDKEEEHGICMRVVDVFMLPNDIPLIVVLYLRGLRSYPPTCSIKWVQDLQETKEIFGMPKIHATEAEQNLLLTILERNSERLSPDYRPKRRSNEKDFTLSFLLPLAPLSQQNIMELSTITGCGMCGDETTSRCSGCLAVEYCGTICQKADWKTHKSMCNSLKSGKNLHLVTMNHRSKPSVDNATITSSLDPAATGTASSTAIPSNIYGSKPFLIKIQRQVTPPGMNVNNLKNNPNSTMMIYDEQRTANFWLINGDDKEAFGTALEETKTGPRGLKVYRWAKRVGDLELSVCIDKGPVRDPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3I9</accession>
    <name>A0A8H5D3I9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3I9"/>
    <dbReference type="OrthoDB" id="2953532at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034986671" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="169" mass="17941" checksum="D6A64AC3111BFDDE" modified="2022-01-19" version="1">MIAFLPFALAFLFSLAGRVSAFTFNVTIGGNQTFAKDILPPGDISALNCTTQCSSVQNTFNTANDDAATLCRDDIVDAFIGCEQCLFNQIVADNSPPSPQAGSNVVVGGYAAACGLFNFTLAVNRTKLAIAPNWDGPFGQKHFDPIKHVNGIHVTVPQSWFGTDTSFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3P9</accession>
    <name>A0A8H5D3P9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3P9"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034948333" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16468" checksum="B506DD54719C2F13" modified="2022-01-19" version="1">MSRFVFFVFTLFATLFSQWALAVPVSSTSSSSNSTSPVLEKRVDHHGRGTWFEVGLGNCGKWSVDSDKIVAIAKSRYDENNGANCGQWVSITDQKNGRHAYALILDSCQSCGRQDLDMSPSLFKQFEPLSIGELKIKWNFMPKGWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5A6</accession>
    <name>A0A8H5D5A6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5A6"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="672" mass="71969" checksum="786C247027001BF5" modified="2022-01-19" version="1">MSSQAEAQWTEPPWSGWIETTGDALLILEAARRGLIPRVNRRLVDNERKMIASGSVFVFDEKESGIKRWTDGFFWSPSRILGNFLLYRETDKRGCGHRGRGEGDDSPPSQTEYPTGGSSLSRPRTDTNMLGLDKMRERSLMGSLTNSYKFKSDGLMKKTFSLHVDGAAQHLISYYRIEDVESGRLRSPSSLPELASLDISPELLDKTHFRNPPKVEVGPDGIPRYRGEADDIDPSPTILSAPLSTGLPLLTDGRHTTDKRSTKRFDPYGPPPTSKRRKAKETDDPSASASGSTAQQQPQAQPLLQAPQPYPDPNQQMMQSQPSSQSQGLQQPLPHQATASTTHPYPHHHPYATPYPVPSNMPMGYYSYHGHTMYSSPYPPPGTSGSPIPAVPPSAQSSPSPPVPSSSTSTTPTPATVGGIPASPTNGSPTAVTDQSAGGGSSQSPVGATPVPYAYTYPHPQSYSQPQATVDNTGAVDPNANVSVSPTQPQAQSQSQSTGASQVQSQAQNQPQLQAQSSTVPTVTAPPGAGAAPAVSRPIAGVPVHPSAYYPYYPPPGIYQPYHVWYGYVPGHGPGHGHGHVLGHGVLGHGHGQAPGHAGGHMQHQQQQQQHQAQAQLLIHTQPQVQGKVPVQVVQMESPVTGRPIPESSSMQQQHEGMSDVEASDTSTDGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D759</accession>
    <name>A0A8H5D759_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D759"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="176" mass="19704" checksum="1413B6DAE1D5A329" modified="2022-01-19" version="1">MSIILDARFDGLHMQADFLAIATKVAFFTTDDPLSFILEGIKLHGNTELDASLSGNNTALGDNVCLMKRSSQHSQTRILESIITEATTRTVESTLYLSVMGDPLSGIAPKKFVNIFFREERLPVAEGNFKSPTELRICHRECLLRQSPQLVNRVFFKRSNSGTDRKVYKALGRHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EWF3</accession>
    <name>A0A8H5EWF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000499">
        <property type="protein sequence ID" value="KAF5314802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EWF3"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5314802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="511" mass="57976" checksum="736F2E3DBE32D146" modified="2022-01-19" version="1">MSVDSPQFSYLTGRATPSSWTWTDFQKHNRYSESPTTDDGLGPHFRHRVGLGNATLFFIDSRLSDSEKATWKNQYHIDKDFFECCDNRVFSRDDRIVTPDDNPVSQEHTRITLSFLHTGPDDLTIDFIGIYVVKVKHPSGHSSSSSPSGIEPSRALPSSNPVTLPVILCYFPHTRLCTTALKSWFKDTRADNSKLWDTIVEGTKEDVSVLLLPILWFTVYAWADALAKFYQQANGLVSVFVAFSNPCQEFDMKSKEEKILDSLDSQGNTKSLSLTKELHKLRNRLHYYRSQLRSFKMIVASMDPILDQLIRTDSVGPGDAVITSSKDFTYFGTQTTRFMIRDSSDFKLFMGSSDEAPKPEASETARTNHVKYCQYSEMVREIERLFDTLMMRNDRMRDVMGMVFSYVTISDSKAMKQIANLTMYFIPPTLVAGIFGMNLKPINADKTPIWIFFVIAVPLTIVTLWFLKAGDSSLIAKAQQKLQELGLGKQLTSLFHPKKRTKGEVDHISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDL7</accession>
    <name>A0A8H5FDL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000300">
        <property type="protein sequence ID" value="KAF5332906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDL7"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="180" mass="19909" checksum="75D2811E25DF73FB" modified="2022-01-19" version="1">MLYAIRYFRRYPADKIPVKVAVLLAVVCDTLIAVAGPTPISCIASGISGAIMQIFMLNRYWVLTGQKFIVITIGHIILTSVASALYVTIRIIVLPHEAGRNQEIVTGVILIRRLMALTLKSGSFTAITAILILATFVGDLHSNIGLIFSYNISHVYSLTLLYNLNIRQKLRNVQVEHTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEE5</accession>
    <name>A0A8H5FEE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_016588</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEE5"/>
    <dbReference type="OrthoDB" id="3252172at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MCM N-terminal" evidence="13">
        <location>
            <begin position="249"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MCM OB" evidence="14">
        <location>
            <begin position="375"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5333761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="57957" checksum="D7BBD46F5E797D44" modified="2022-01-19" version="1">MICVRTKPQLSKPTLNQDASRQRPHDVFSSKTRFSVLRQRYPTRLLNKVLFSSLASLLPQQALLVRILAEHLRRVRLYVELRLDELLGWRAPRLQSTFPVPLQPKLRAVVVDASISLPMLWIILILFIFLQALPQTQYPPKNRRGDIHSSLGLTTRSRRQTQTPRTLHTPRAGADALASDADALASDGALPDIPASSAAPEPGDGSDVGPLSAAAAPTDEPGELCTIWGTMLKYRVAFDRAQASLSSFSSPAVARTHAHPEEGEKPVYEEYMRLMRKTGETNLNLDIQNLLAYPPSKKLYQYVIKHPQELIPAMDTVLKEFMLEEQCLTPSLQQIAERDTEESRDGMEGQVAYEEIGEIMGKVYKVRPFGVKSVNMRELNPSDTEKLVSISGLIIRTTPIISDMKVAFFRCLVYSHTVQVEIERGKIAEPGRCPRDVCPSVGSMGLVHDRCWFLLQMRLCRPPNLAYPRNTRLYTTSSSMWVNLVTGDRIVVTGIFRSVGVRADPSGRKRKMEEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEU5</accession>
    <name>A0A8H5FEU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000276">
        <property type="protein sequence ID" value="KAF5333972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEU5"/>
    <dbReference type="OrthoDB" id="3069970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5333972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="17377" checksum="8C9BC5287C928C8E" modified="2022-01-19" version="1">MIWLERQEEKNSWNKPRREAGQTGRGSQSTRSGRTRSMEVNAFQDNLPGASSTMKYPPKLTPQEREKMRKEGRCFRCRGLGHMGNDCPTFPNTPQINPNNTTWRPSIKQAAVETSESKVNTTTDNISELTARIGALSGEEKEGLLKKFVTEADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFN5</accession>
    <name>A0A8H5FFN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000248">
        <property type="protein sequence ID" value="KAF5335036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFN5"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="87"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="30262" checksum="363364173D92B1F3" modified="2022-01-19" version="1">MARRGYDFAHRIVSLMSASVRSAELGRPSLRSFLHSLLMVYLRWKDTISVVTSPHDPLQKRTRPRRLINTRTIKLEEFSSNDSVPPYAILSHCWEAGHEISYQEMVKCQLLTAASIRSKSGYRKIVAACMQARKDNFTYIWIDTCCIDKGDHGQLSQDINSMFDYYKNSEVCYVYLYDYYPWFSRGWTLQNLVAPWNLGGCSWFFRGWTLQELVAPSSVKFFDAKWKYCGDRKTLNIAIWAITGIRWGLLEGGKQSKMSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJF7</accession>
    <name>A0A8H5FJF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000189">
        <property type="protein sequence ID" value="KAF5339029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJF7"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="419" mass="46477" checksum="027702A18C196A49" modified="2022-01-19" version="1">MSRLLLSTPFTSFPNITPAHEILPMDTVEQDKNVTAISQLPTELLLLIMQDFIGLSDTLKNCSLVCRSWSYPAQRHLFVSLLLQSSESCHRMNDLFKNAPHLGLHVNNLTLSNNGAHRSCGNIYTLDIDVEDTEWHTSGQDLVITKLKSVRNLTVKGRMSWDDLGELLYELPLLRSVRILPKQQQQSSEPILATPNHDDHPSPSGTLYFTSPFRLESLVLSGIEVPGHESFLEFVNFSDALDFSEMRSLKLGWLSHPPAAREFGEQAGITPLFEEFFPSPRPTSVPAPRRLFECPAFGKFAETLGLLTNLRELKLQLASELTIPDPGMGMGMGMGMSAGVLQATPMLIALLVVYGIRYPDTSRTTPISPTRNGAQMQLETLKLEIDLELTIPSPSPSPHLTRIRAHVHNAICTSACPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKT0</accession>
    <name>A0A8H5FKT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKT0"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="66669" checksum="4980F9D439E585F8" modified="2022-01-19" version="1">MLRCILSNCSTTCGKGYNRNTYYRGLIKRLVSALYTPIHDMDQNTSTIAKLRAEQVDQISDNLSRSLYQLAPLDASADADSSSPSPLPQQLQWAVERLKELFNELEPEQLLVVLPEIRKLMDLGRYNQSNGLGLGLREFDEFGQLLGRLMTVKERRSKIPVVRYLPCISDFPPSELNGPASSEWLAMFVHSDVPSVCIEDYNACCNICLEDFEEPALALELLQVDGDDVDLMAKDDRTQASPKPLRQLICGHVLHVRRLPAMFQGDNYDEMFECPVCRAEVWTSLPDPQQFSLLPPKIPLEIARSSVSSDQRQTYDDYYNSLRPWQKIHENLLNWATSTLRMSDFDQALNSTTHGHPVNEIALFIWIMQTYRRYVYSRMTDSSDHEGLVDCLVLDHVEAWSIGSFISEGEHRAASRGLREFWDVSGLQDAPRLLAVLAEHSRPDGSCHWVVHRFSLPDGALTTYHFYPELPACPDCRPASWWPAIHLAWPDAVICPDPSMPTLIHLHRPVQLAEVDNFVAAVGIWYNILMGLPAECVDLERVRDVIGTEVESLRERYNSWASYLSTFFGDLYRRCERVEGDRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNP4</accession>
    <name>A0A8H5FNP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1427"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1469"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1524"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1560"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1592"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1631"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1663"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1688"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="9">
        <location>
            <begin position="145"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1343"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1196"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1386"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5343930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1726" mass="185272" checksum="5D3547197A4DA755" modified="2022-01-19" version="1">MPSFLSKVFGRKKTDDKDSSGHGSDPSLLEGKFEAVSPNVSPTAEKFIDGSTSKDKGDKQKEQKPKEKGKDSPFSLLKSKSGTSSPDVTTPKSEPYSHLTLNLPGLKDDDNARALGVVFEADPSQLILSDAVIGSRRLTSLETLVLVRACSQAIMARGLETLGIMHPHWHSSSPDVQRKLISLFIHSLAPKSPITTLSPTLSAPTSAFESEINSTRSPHDVAAVLRWGLRHMQLDGSSFGKDDDWYKSFFEAEKSAQYPPTAFSEQLAPKIPATHFALLTATLDLFSSLAAHAEANSVSGSKLSKLLGLWLLTADRAQPDDDWHSFYSRWDKMGRMLEHMFLSHIRNEAANHRMPKRLTELVQHYPYVKGSSPSPDHDLILPRPRFSTPRFDALFVRVDSELPSGLSDDKSFSPNLLKLITNALKADTAGTGAPYELWQKVKQALSEDEAANEQGVLTSSASTRATENLSRILADETIRLLSFRNARQQQTATQEFKLDAAALPAGRANGHTKSVSVDHATTTNGSAFSREKQATSVSEGAGLTNTASSSPPSSPTQMPNALGIDWTQFSRSGFLESSVGVQLAATLMDRDLEVTTPKEKEKRSRSLGRRSRATSPASKRRATKTDELPPLTIPAGGGGGSGEKEGKLSDSEAFINAQLPTKVTQVSLVQLDEGFIDFWSDALVDPISSDWPRFIICRFKNSILPGLDLEGEGEGKKKKVEWMVIEQVYSKPVLTSVSQPITGGTSDSTHETTGVSPEKERRGRPSSPRPSFSSARQRFSFLSATFGSKSKTEKEKDKDNETKKKGDKGVKIGEMGEILKEEDEGEKEKDVKKEKEKKRSSWALRKSADKEPKEKNEKGKGEEDKKEHESKVPVAGIAAVATGAVAAAAGATVVAATQAEEKKEEKEGEGEDEKQVEEKPAEHAVVAAPEVKEEQPARAAVPEISASSSAPEPEPVLEPVVEEPVPVPVSVPEPTPTEEVKESHPAVTAAPELPEPTPVPVVEEKPLEEEQVEEEPAAAAAAVEPEATPAPVEATPVVEEEKPVQEEKAVEEPVPVAEPEPVEAVEEEPVATADLEPTPAPVVEEEPVAAIESEVTPVPETESVPAEAAPVVKEEKVAEESIATIAEEVGPSEPAHAKPEPTAEATSELAAVEGPAVSAPVEEAKAEASVPPVSEPEPTPAPSVEEVKTENPSTDIVEESIPEPVAEPEEAEPVEPIVEDTPIIVNDIVIPPDTTSSAPITESSKPEAIAQPPSEPVASFAETTVVAPPIKEKVDEDAVQIPSVHIEPLREPSPGPAEDAQVSLPAVPVVDAEVPIPEPSADVPAVDLVGEAAAPPTTAELKTEVVDSGLPPAPESVVLSGETPGPQVALSSSEPAAAALAETDADAEKAKGDEHEPDMPPGLGDTAGGCCANVWAYEQLLVMNPRIGSALTFSQMLFITLQSLPSFLVIPPKAMLPRLRTRQVPLYQWALQVIVLSTGSLLNNWAFAFNVPLTVMIVFRSAGLAVSMLFGYIILKRRYSIRQVFSVMMVSAGVVIATLSKSPSSTKASPKETSDDMQKYTIGIIMLVLSLVLSGILGILQEQTYKKYGPCWKEGVFYTHFLSLPVFLFLIKDVKQGLNSLSSTNTSSSTTAAWLILGGNLVSQLICVSGVNRLTSRVSSVTTNLVLTTRKAISLCFSVWWFGSGWNMRLAGGAAMVFLGSLLFTLDHGSKDKDKAKEQVAKKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPM5</accession>
    <name>A0A8H5FPM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPM5"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="26834" checksum="3633BEDE2CB3A998" modified="2022-01-19" version="1">MLRCRLSPSPFLRRAYATAANDASNIRNMALVAHIDSGKTTLTESILLRSSYLSASGSVDTGSTTTDFLPAERERGITIQSASIPVKWNKWTFNLIDTPGHADFGMEVESASRVVDGAVVLMDSVEGVEAQTKGVWRQLDRYGVATRLVFLNKLDRPGASFGSSLRSLLTHRLHQHPLALTLPIASFDPKDYQHAEPGIQGIVDLVKWEVWRWDENGEAKRYPLPTDVQELEKLSFLPSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ03</accession>
    <name>A0A8H5FQ03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ03"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="15139" checksum="BDC4866134435EC6" modified="2022-01-19" version="1">MSNPTLRTDRVRLLVLITKNSSISREEFERYWLEHHSQLLLSLEIFKKNVLKYEQLHINQQTKDLLQSLGAALIECDGVVILEAESYEKLFETFNDARFKAIIEPNEKKFLDPSRTKIIPLDFVAFIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQU7</accession>
    <name>A0A8H5FQU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_011911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQU7"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5345761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57987" checksum="A4D8111BD45D491B" modified="2022-01-19" version="1">MSTPGTNTPFNIPVLLASVSVLFVVFKLWRVRVEMAKLDGVPTVGSTGFLGSLVSGMRFVKHAREIVNEGYEKYYGRPFKIRTSDHWIVVISGPTLVNDIRKASDEYLSSNEAIGDALQFEYTLGKSQRENDYHVGVVRNALTKNISNRFDDIRNEMMTAFTDEVPVTDDWTTVNAYDTIAKIICKTTNRFLVGLPLCRDPDWIDLNIQFTIDVFARSSIINLFPDILKPIIGNLLSPKGAVLKRALPHIGHVIRERLDKEEQYGWDWEDKPNDLISWLLDENPGGKYRAVEDITMRLLGINMAAIHTTAMVFSIVLSYLAIQPDSVIKALREEIESVVEEHGWNKVSMGYLRKVDSFMKEAARMVGIAQVNSDRKVLKDFTLSDGTRLPAGSFVSIPVSAMHHDQRYFKDPNEFKPFRFADMRDSEENGHLKHQMSSLNSDYFFFGCGKHACPGRFLAVNELKTLVGHTLLTYDVKLQEFKKELPVFSSFGNAVVPNRKLKILFRKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTW3</accession>
    <name>A0A8H5FTW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTW3"/>
    <dbReference type="OrthoDB" id="2884727at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47805" checksum="BEE5EDA9E3F0CBE9" modified="2022-01-19" version="1">MASTAHITSSLWSSLFIDLLNYEQWPSPYPNSASLNAMLDHHLKLSRNFPLHISLILPESNEDTRYVLKTLSACSARWASLYLDTDWDLLRDCDFRRVANNLPLLKQLWIEGFTSSLSQEITGPFQSAPILTELSIQGHRPPSPSSDARLCFPWNQLANLTLRHCLTSTALQYLELASQARQIALLRCSNNDFRARPGQYPRVIRCHRLLQSLCITIDDRDPELSVIFNHLTLPSLTDLQIAGFVDEDEDNIDGPPSSENFFFTSEQGAITSFFARSECRLTSLSLKNLPLHDIEIISFLQQIPSLTVLTIHEQLDKDEYDATSFTSHFFECLTIGYTEPTCTLLPRLAELDLRYDVSSFPTSDFLRMIQSRWIPDAAYAAQLGVDSLTSVTLRPQKHQDGKNVELGLDSLKALHVAGLCVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX51</accession>
    <name>A0A8H5FX51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX51"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034053621" description="Glyoxal oxidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="70"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="458"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5352184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62250" checksum="AC7F9297BDEB57CE" modified="2022-01-19" version="1">MMWATLVLTSVLASAIPSTISQSEGLGWHFVQNGSTQLTALEAIVVSPTLLVVFDRVAGDPLQINGHQAWGAIWNTETNNVTAIDVVTDTFCATGGILSNGTMLSIGGQPVENLTSTPESPYPPEKDGLMGLRIFEPCLDPAGVNCTLFENPETHSLDEKRWYPSSLRIFDGSLLIVGGIHNSTPFFNDKERSASSFEFFPKKDGGVPRPSEFLNRSLPANLFPRAFALPDGKVVMIANNQTIIYDVEEQTETILPDLPNGVRVTNPYDGAVTLLPLSPPDYIPEVLACGGSNATDDFTNDEVDRLSSQDPASDQCSRIVLTPEGIAQGWIVETMPEGRMMPEMILMPNGQVLIINGGSTGYAAVGTVRDPVGRSNADNPVFTPLLYDPSAPLDSRMSREGLPTTDIARMYHSSVSLLPGGNIFIAGSNPGSGIHLDDKFPSEFRVEYLNPPYMTVPRPSFSNLPEKVGFNQKITLDVEIPEGLNTSSIKVSLMDLGYSSHAFHSSSRLVFLEATLSEDQKTLEITTPPNNRVYPPGLAWLYLTVDDVTSKGSQVMVGSGGTPPLPDEGVPIPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXS6</accession>
    <name>A0A8H5FXS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXS6"/>
    <dbReference type="OrthoDB" id="3158970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223021" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137467" checksum="43E58A2CCC45D4DF" modified="2022-01-19" version="1">MRSFVMLLGLRIDHFGVFASSLSSTTMDSQSSTSYKGKVTNRGWSQLPAELIRTIATNYLWDVSSTKHCPDTWNHRVFWQSRLVYTVLRDAVQMETFMQICPQWAAAVEHHNFWDHAINVIDPRDVLIMHSFTQPPNAANSMTKASAGTATIGMAQPKHIKLSPFAHFKAIAHWSCIVCCINHPQSNHGLGKARYPFYHTLTGNWGLCPEHNGGPDRPSARDRSEREHERDRERSTFCGLCLREAQPYDLHIQYGYGYGYGQQGLQQGMDIEKSRRNPTFYTGCMENEDENTFPNVETTCRSCRQEWLMARIHQLPEYRWYRDRVRLTGGKSGLPRLEAWDWDHEARSSVESFIELGEGSVDDIVALVRDRWWLRTKTRLGGMLEQAIAAEKFLGGETTLPGTGRSRGRTMRDADGDLDVDEEIEEDTEEEEEEEEDTELLQITEDSGVRDLALSDWARRRILDGFWISPADQWYKYFLPPTPGSPAPLFLNAVHPCPWSLESNDTDSDPLSPTSTDLDTTEATPPTHPLPSTIHSSVPPSFHLCEEAYSAFQKEFRLVLLPGMRNLVRRLVIESHAASVEAAKLGVPPNPKLGDPAIRASRMTIEDVVRELRECEGVWWDGWDWVRHGEHGEGGNSRKEVEGDTGMNTSRTTAESDGDSGSCRHEDEQHGHGHGRHDEHGHGNGNGNGHQHTHVREGSEKSSSDESSTPTSTSTLTSPVLSTSTLGTTPSPPPTTTHSGDEKEKDGNCNNVSKADSPSSVSVSVPMADADADADAEKTTPTHTQTPAQSQSQVPVKEKPVPVPISIPAPGSIVVKPITIPISPVLDPPRMLRPIPYIPVSIAHLPQYSLELVKNVWREACAPLYHCRCRICIRAAEKANAALAANNPLNSISRDQKERWDELQNAQNERQINAAANVGKQDRDRESQLVQIRLEEADDVDADTDADGTPVRVEYLDDGDGDGEVEELDYASEEAEYEDEYYEDDEDARSDICVVGTKGGRTQYVEDDGEYDEEVDEDAKLRAYRKSRERDRYTRSRSPEIPSIHLLLKFPDEKGDDEKADRPSSTYSSHETLVANSPPSTPVRRIPGSRKRSCDEVDGLQGDDVAVDGGVPSTPPKRQRLESPGPLASLGLFPVPAEPASPARKRSSEEIDLEANAEESYERGVARGYDYGRKHALAVDAGGGGGKDGKDGHRNSERKYKRFKTSSSEEEEAETPPRSMTGDSDPEERGAEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FY71</accession>
    <name>A0A8H5FY71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FY71"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="427"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="838" mass="91964" checksum="774F0409501DFAA4" modified="2022-01-19" version="1">MSQGPSKWRSTATSATASRLSSFKNYISQQDFKNSLPQAIQRQLDNAKPGSWREWAGQKINRSGNSPSGSQTKLAMFPGWAARKYRPGKNRDVGGAFLLFLGEGVFLSFRIDAFEIDVYVSGFATVYRAPEFATRSQKAFMRLAKGYAALPKLEGQQEDPNEVLMSYQLTPSTEDLMKTVKLPPRPMENTDDYEAEALEQHFQRLNANMQDSLQTSPHSSSVDLPLSNTRPKTPIRRPTQDSTHNPINAVSEELRKLHANLEGIIFAFRSTASDSLYIPVARLQPFWSSVLPNRLVRINIFASHHKSPENPSTSSDADVDRVAIEHGPIATQDVMTAADGSFQARFRIDWEEMCQHDAFLHIAFGDPLEEHDILVTAQVIPPSPPRSTYSSASSSTSDLENYSQQTPVPDCPPPVHMHISLTHTPLRVVSDVDDTVKLSNISSGARAVFHNVFVKELSELIIPGMGEWYTDMWRKGARFHYVSNGPFELLPVIGEFFKIAHLPSGSIKLRSYAGKSLFSGLLSAPAARKRAGVLDIMDAFPDSKFILVGDSGEQDLELYAELARDKPSQVLAICIRDTLIGIADPLSDPTGRGSGYYGPADDVPPLQLPPKPPYSRKPSQSQSQSSPSPRRALTGPERTLTPMNTTSMTQSPPNTSSNTSYIPRTPQTQTSRKTSMPTPLSAAPSYFSSSTIMAEPEVIAPMSASVLNTPYSTGRKSPWGSKSSLSMSVLPNTPYSAPNASNASNMLNTSFGTQSSRPRKSGSVHSVMSNATSASASGSAYGNGNGKPLADSERKRYDLQVRVWNARSVIPDGILLRVFRDPGECWAEMDRLIERLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYG7</accession>
    <name>A0A8H5FYG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYG7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="141" mass="15458" checksum="35D5D22B53CFABD1" modified="2022-01-19" version="1">MDGIGCTSGFCCPVCASGYLYSGRFLIVQRICMDIWAPAIFHFAIVHVEFLGTSSWTCTESYFPLQAFPSHSIFYPQVMGPEGPWERLQWLQTIDFAYYLDGAFMAACGALVAACVAFHGLTICPTAQDLCPAAVVDYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0F4</accession>
    <name>A0A8H5G0F4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0F4"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5355348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="453" mass="48846" checksum="E1E531D6BD837423" modified="2022-01-19" version="1">MSDSMLAARDAKAAFEASQLIPTSERIKALHEIRDVLERGKDEILEANRQDLQAAQLEVEAGRMSESLMKRLDLGKGDKWDSMLQGITDVAALPDPTGNVSYASELDDELELYRVSCPIGVLLVIFEARPEVVVNIASLAIKSGNAAILKGGKESNRTTALLSKVISAGLGQTSLPSTYIQTVQTRAEVSSLLELDQYIDLVIPRGSNSLVRNIQNNTRIPVMGHADGVCSVFLDETADVEKAVRIVVDSKTDYPSACNAAENLIIHEAVLNTVWPAVARALLEADVKLLCDSASLAVLKSLSPVPKNLDTHVQPSEPSSYTTEHLSLTLSVVVLPSLESAIQFINSHSSHHTDSIVTESDTSASIFCRGVDSAGTFVNASTRFADGFRYGFGTEVGISTGRIHARGPVGLEGLVTYKYMIRSKGHSGHIASEFGTGRKQYKHKKIEATSVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1C4</accession>
    <name>A0A8H5G1C4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1C4"/>
    <dbReference type="OrthoDB" id="3120053at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="273" mass="30577" checksum="EBC5B63EC2CD3740" modified="2022-01-19" version="1">MSLKLNVVSKHMDYTRIYPLPSLPLLHVLHLELPFTEVNEQRVNDPDRREMFTSTLGIRAFLERLTGNGKLGLASEPDEPSYPFPSLQTIRIFAPSYIYILARILQQHNISESTATSDLADLDMDGWDILDRRILLDEKFAACKEVIFEIDPKLLHSLNNGTGEEEDHEPSRLGSGFVQVDLDLDSVASFGHRDGNGIQGMKLVTGHSRGSARRKGSKAIVKPVTRTVNVAEKLFVQLQGLLVKWLPRCTGRGVKVRCAYRERESGRLGGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1I6</accession>
    <name>A0A8H5G1I6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1I6"/>
    <dbReference type="OrthoDB" id="3268380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22160" checksum="AE930D34E6C8D47B" modified="2022-01-19" version="1">MSTSPMGSQLENMNHILSLLRSNSNIHPPDVSLCLTKTERDIEQISVEIRRLEGKISALRVKQEGLEWRAFRYQSLLAPIRRLPPEILSRIFEFACQDGCQIKAKMSSSPAQTSKVCAGWRNTALHNSKLWSTILIKSTGFKHPLDPVKQLLTMHLEMSKQSPLFLTVWMPVKITPDNEVALFIVKALASHSNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G367</accession>
    <name>A0A8H5G367_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G367"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="302"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="396" mass="45182" checksum="0687C808E5220DB0" modified="2022-01-19" version="1">MDIVGSDNDKHTHTFDGEQVEIMTDIFDICCPHFWEFAANGIGAIPWCICALFLFYSSVEYTGYSDEMISRKFWVPNIPPGRSEGQDWMQRYLSTMLSPPTAAEDYGRACDYMDLEFAQLFGKVFECRSNIRDSSYSWYNPPSGAGLLPGGPLGPEQWSHINAQHCKEYGPDPSFTGHEVETHCLIYIPIAGSKLDELMHLEFFVIVLTRAYTSEIDVILWKDLLQCMQDANQRHIEVDMEVKALKEITKDLFYLTIVALIICTYVHSKLMYKCNAIIYASTVHFEDNITKIMWALSYFQTGCAATYHQSLTNHGYLYDSSCFDTWREFETEFIKEFMPEDERTQASLTLEGVSYFQGTASVDEYVDNFCALITLAGLNVEPVLYSMNPTAPTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Q8</accession>
    <name>A0A8H5G5Q8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="966"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="645"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5358909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1709" mass="188635" checksum="DFB8D2AE1EEE7C6E" modified="2022-01-19" version="1">MVYPDGFKYAVRSAGGILPLSLLLFAYERALVPLYASTPTTFLLDKFLLCAALVAFINPIRLSKSSEWFLAGILLTLAPNVTYWVPVWTIRKWKDPYWGPAIVHAAVLVPLTLSYGTLVKPRSNVLLRATAGCVSCLGAIWARRLWANFVFLRDISDDQIFLVHAALAICVGIVHLHVTSSAPSTVKTTKGRKQTTTSSTYSSLQIKGLILAIFLSLWLSFSSKLQSPVLPHPYPPTSVEEPKILSKGPRRPAGLPFRHPSYPLIIHSSVQSDTGLIVVGEALENPNAEGSVPHAVRYLRAAHSILGGVWVGSNVRSLDDEAPMYDSRGKALGDSIYGTFVLQEAARLVNSTGKGSSTEDWKNALIIGLGTGISATAFARHRMSLTIVEIDPAVYDAARRYFGLPDPGVGNVFLEDARGWTAARSAEMESGKQGVFYDIVVHDCFSGGGVPEQLYSVEFWNDLKKIVRPTGIVAVNIAGQINSQATRLLLFTLESVFPRCRAFYDSLEKIPEEKYGDDFGNQVYFCTMSTESITFRTPTVKDYLGSLLTKHMLDTLPDREVNLDVLRESYEEDPDLTVLSDANNPLGRLQEEQGFEHWLQMRLISSTCPVMRQVLPDGFEYSFPVLAAYTFLMSDPQRISSPLGSSPSRTTSISRPAWPWSSASSSSLRHSHRSSTSSVASPVPGAGWERATASPAPSLAAGTGSMSKQNTGYSGNDESENTRQWTYMGFEWAVRNASKLRDFIEGVGSGAVDGSSEDSRNVNVDFEVLKLSPILGDNKFKLEIVPTPSNDGEPNAKTPGLSLYVTSLMMDYAHAEYEMSASMMAAIKCQDDRLGQRGARPDFIWEHWQGSWSFRQDSEFWACSLPSLSSLLENPRIQETDSFVICIQIHCPIGPFFPSQPSVYYVPRDLLDGLEASLDNPNTGDVRFVCLERWRPDEQNSPLLSPDAISPSTRRPPSSASSYSPFAAEMIARKRIIYAHSDILTRRSEYFATMLTSSFSENQAIMHGERKIFTIVVEEADFETIYWLLKYCYANWLLFKEVDDPRVAVEGVGAGWSASWLHSRSGEWDWKTFNKHGLADDSPSGDARSAASGDSVCSNVKDTSIWPKSSIQSYIYETTTSRVTSSGSTPKGTSNNATSSRNLTSSTGPSTPRRPTQAPASGSHMSLKMPASPSAARTKPIPLSVANSNFSTPSHYPVSPHTNRPRVSSNQAPDPHQHPTPPPAPASPLSMYQVAHRYVMPALQVLALEHMMSTITPQSSFALLLATTAWEDLHNMVEDYVVDKWDEVSVSPEFEQCCQEVAGGEWGAEGGKTMTALFRRLRSPTALMYKLLRMVASPRRSSTLSLTNKNELLSSGSLQRPSPMFCVRATFLQSSRLQKRGLATIADNFRIPVINFAQFRTAKSDSEKKATANDIVSAFKESGFIYVEGHGIPTDASKSAEFFKLPTETKQKLAWEDPHSNRGYVQVGRERVTQAVDAAEIASLREKAPDFKESMEIGRDWDSEWKNMWPSETDAPGFKSTMLDFFQTCHNLQVEMMRSIALGLDLQEDFFDKKIDKQCHNLRLLSYPPMKRSLLDSDGQARAGAHSDYGTLTLLFQDMVGGLEVKNPHTGNFIPATPIPGTIVINVGDLLARWSNDVLRSTLHRVVAPPAKKINETEAITPARQSIAFFSNPNFDAEIECLPNCGSPAKYPSVNTEKYIVGRLAATYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDA3</accession>
    <name>A0A8H5GDA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDA3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="215" mass="24469" checksum="39B950C6504182A1" modified="2022-01-19" version="1">MPRVPTPKQLFCTVEGCKRAGKPFTRKADLERHHNNVHTDFKFDAHQTVAPNRRSQLPAQSEKVKSARFRDRFSSVPVRAEFWGGYRSVAAYGEYGAGLPFTAIESPNTNRVSSEPRGRIAAPNSTHASRFLQYRLRLRPGSDKRVSFWALTWCTSRFNQPLIEAFVYLQPSSNTENPIQLQDQNHHGIGRQKLQMDVTQTKVRPHAVSLAYMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDC6</accession>
    <name>A0A8H5GDC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDC6"/>
    <dbReference type="OrthoDB" id="3221808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="75"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120822" checksum="91E4DC8C6DCEE41A" modified="2022-01-19" version="1">MTISLLVKVFGNLFFRKKKSRDLESRTAKSENGPPGAVLGEPTVTVANAILPNPSPRQKGPYMPTADDEASAKLWSVYIDEARRYDEELLRGWKGDMDGMLLFSALYSASLTAFLIESYKTLQDDPAQDTVFFLAQISQQLAAASSGTTFQFEPPAFHVPTSAIVCNVLWFLSLALALTCSLLATFVQQWTRDFIHKTNLKPSPIRQARVIAYMYSGLRDFGMHSFVDLIPILLHISLFFFFAGLVVFLLPVNRVLTYIMACVLAVFLLVYMILSCIPLLYLNAPYRTPLSVALWRFGNAFSDFLVHKHSLLRRDQTLNEAMVGTALQDTAARDQQAVIYTMKSVTDDNELLPFLEAIPDAIYKTSTSVPDVEYDSSSSEWIRNDIRESNLPIFMLLLQTSDPEVNILDRLAQFAGNSGGWTDPVFADRSSKACFRALWSLIYALFKPSTDPHSQGLNLGNDYLQTYRDSIEYLWLCIRSYTFSEPSTIPHEYIPSVQAVMRISLLYSLRNVVYAIEDAFSGSSLMSASELRGQFALVLTTWQSILGYPSIAACSIEHDWPLSSLLSTLLITLRKGSVSPDPFNELICAKQSLADLVSDKVWQDAHLSALATYLCDVGSLMPKNLLPYEFRRTCQIILPDVEGTSTSFSITIPPSYIRDYAKPLLTLKTLLDGGSISISPNTDLYMIQCIKLFLSSKAALSGSPEAASGRRFVLEYCCQWKDVDDHGSHFPVLRNHREPSLNAFSTTLSLYVGECILKEVGVMDEDKLALRAALFLLKLTPRRMVRLWDTDFPLRLWKAIIRRGDGVDPGWPLEKDYLLLKANLDEILLQHICGPVRYSDHLGLNKEIQMRLIQEYLPHRVFLPPLPEDKPCTGSLWIALLVREVTLLSQEPTLEDESLWKWANWAGYLLQDVRSDMKVDEIVQLQFARSLSNLCDTIITQRAEHRGEYHLSRIYLSICQSLGLVCSWEWVTGHRGIRRLMKAILRIDEYIEAEAKRNTFSEMAFHYGHNPLIKRCQIVLAEQREKNRRRWMDKKKRSRFIAQKEKSQARRISSKCRVRIEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDK3</accession>
    <name>A0A8H5GDK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDK3"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="501" mass="56707" checksum="2F0858939053CC18" modified="2022-01-19" version="1">MPPRIAVRYLEVDVEELSFLKMTKSRVSSAAVYKYLRRPVPLSMDPSSPSEEIGLVLLYLHALAHDINEGDTPAKRISIQEFERHWVPIWSWTRALVTRYVLENQPCTKEGIECQTLLLKVFPMVVTLPSLHESTLDTSRTYTLMQRSSDLFLIIVRVLVFTLDRQHPSLTSLFKVLDIALTASELPDARGGLAQVSSERTNTIVRIPGVIESMLSYIYFALHERGESFPARELSQAFRSVGLMMTSGQDVLDTFLAHGILPCLCRSFKVLISPRRIAKLPDPEIIVESVKYIIKVFMNTLYYYSAPGCLLLIRAGLLSFTVNSWRLISFDEEAASPRTFALFEGRTLADFFIEILEPVPNMFGSRLILNSFKQAFEKLQAVDQDALDAFMQLNNPSSRNPNHRRLGDVWRDLLLQVSTMKRARVVFEARGLIVCANPEGNTRIPDFVVCAVRDVKSRSTALGSARNKTGTYTIIDRNVRIIVCQMIHIDPSRQDLYGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDR3</accession>
    <name>A0A8H5GDR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDR3"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="538"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114089" checksum="830888535B5DE2AB" modified="2022-01-19" version="1">MVRRSLQIPKALKSGCGHLRFWNYKRHFAGGSVRFNPNGLRYFLLLEVMEKGLPAPLFTPERPRKGSGRLLRVGCLLSLVVVCIYTGLVTRLTWSTRTSTAVPINAAQILDRCANLHTLPGPPSGFYSRKQSDRFEAGTRPVLIKNATIWTGERNGTEVIHGDLLLDKGIIRALGHIKASTIHKYGDVETIDAAGAWLTPGIVDMHSHEGVASSPALRGANDTDSEKGQNPTLVALYVSSYVHSVLVAPLDGLNTHDDSYRLSIAGGVTTSLILPGSADSIGGQGFVIKLRPTSEKSPSSMLLEPPFKFNGSGIEPIHPPRWRQLKRKPEQSILWDPNGQHLESPSRPFPSAFLPISAKSYETARKIKLKQDQYCEKAMAGRWRDLDQDQTEFPEDLQWEALVDVLRGRVKVQNHCYEAVDLDGIVRLTNEFQFSIAAFHHAHETYLVPDLLKKAYGHPPAAALYTTCARYKREAYRGSEFAPKILAGHGLDVVMKACTLAFLPVKSDHPEAFDSRYLLYEAQHAHYFGLLDNLALASVITTPARVMGLDHRIGFVREGYDADLVLWDSHPLSLGATPKQVFIDGIAQLKEAHALPAKPSHLRKAPITPNFDMEAEEAVRYDGLPPLSPRESFHDDHGVVIFVNVESVYAKMGGKVVRVLGGGTRAKGTKKNMGLVIVQNGRVVCQGIGAACAGEVERLKKQGNAKVVDLEGGSLAPGLTSYGSYLGLQHILGEPSTNDGEAPDPLTENVPGILGGSEAVIHAVDGLQFESRSALLSYRNGVTSAITPPVSSGILAGLSTSFSTGASNRLARGAVLQDVVALHVAVTMGSESVSVSTQIAALRKLLLGDTKGDLGAYAGKVVNGETPLVVAVENADIMASLILLKKEVEATSGETMKMTFTGASEAHLLAKEIGEAGVGVIVSRPRPFPSTWEQARILPGPPLTQDTAIKKLLAHNVIVGVGAGYPSPGMARITRFDVGWISLDSAGQISKADALGLASVNIEKLLGTDTDEGRNTDWVATRGGSLWILRPRLLVLCQVGEVWWICSDSDLKPLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHA9</accession>
    <name>A0A8H5GHA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHA9"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="581"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="809"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1171" mass="128654" checksum="450F560CD636E6C9" modified="2022-01-19" version="1">MGRPPTLQELYSGTLYSKGHGCALLKPERPQIGTQPIVRDVYVGDVGLVDHKNGLFIPLFNIFESHIQTYRGVPAGFASLEFHEDLLVTATGYFKPGTRIMSKNGQETMVDLSGSVLNPGLPMAPGMSVHFQFVRGKGSLLLLPNGATRVDYRGLECIRAHAMENADAWYEYAEQLGETVPDGSLYVITGFDRAKCYKNAAFLASSTELAVSVTLSCPILSNNSFGELSVTSRPLSRVLHDWKGMGSSEEENLYVFLRGFKIMTRRRRSWRRKFGTELMSLTDNGKLKDLLYQGEASRSLPSLFASPGPASSPQHGSISPKNANSTTSSSESNNMSPDQDYFRSWSPVHSTTQRSSVSTNTDDTGLISHSSTEGISFLGSDEEFESDVSEFEHPSDIINKYILEKCNASVAITHDSEWSSVLEEVYDELPEKATLISLMLTKFPSKFKGGKGRAGGAVCLGQANEDGVHDTQPQQSCDAVPLPNIPHSEPVSNSTTSLNDGHVRGYPQASEQQQEAIRVTRSSEIVRYGLKVAGLGTEVTSSVKLDMDTGRSYAKDDGQLARSASIRISDLAHVDAKPKSKKRALLVGISYNKGLKGPHKDVIAMRSLLIEKYDYLPDDIVVLVDDRKEKSLQPTKANLFRELEKLIDDAKRGDHFFFHYAGHVVQGQEDPNSPEEDRREEYIVPCDAREPIALQDCIQDDTLKELLVKRLPVGAHLVAVFDSCHSQSLLDLEHFRSNRVYVPWISKGRRKSDSMWNDVQRKQAILRTRTIHQTKRLTEGKVKSRRTSVDQVQLNITANINPKVKPVNATTDTSASSSSTIGSSDSTSTPPSLTSSISYTSQSSQSSARPYMSPMTPVLLMTQTPRKPGSVPLTPIITGSRSSLGQGQIPTVPNPPTTLSRAATVTFSNTPLQKLNQRASRGGSFDTILGLVRRSSRSPSPTPSPNQRRKSMMTATKKRQSLSTLDSLYTPFTPCFKEDPLPEHPDPEGIEPEPRIVESPVQGYCSGDCRKMLGKAIEERNGAGAGAGAGCGHGHGHSAHGHECEGSGSQDEGMGEVISLLSCRDNQLAWEDADGTSMTQVLVKQLRKQTHPSMKDLMANISHELHKAAVVMHSSTKTYKKSMVIWRKKNQQPIPRGSTSDTSGLEMSDFQDPQLSTSSRKPFNMERPWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI99</accession>
    <name>A0A8H5GI99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI99"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034833212" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="274" mass="30396" checksum="FC1CEA57DA42B8EE" modified="2022-01-19" version="1">MHSLFALAAFASLAMHASASCSYGTSLHRRDAHGPVHVASYSYSGTTGPINWAGLKPEYHDCALGHNQSPIDFNRSMAFATEKPLLNIPPTFGAEIENLGSTVEVFLNGTTTYVGKTYNLVQYHFHTPGEHRINNEHYPLEMHMVHQADDGSFVVVGILFQLSEKGKTTEFVRQTIINLPAIREPGTRSFTGYLNFGVLALALQTQPIYQYSGSLTTPPCKEGITFLILANPFPMDVTSYNSLKAVMKFNWRYTQNNLNQDNLLQISAEQLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKV2</accession>
    <name>A0A8H5GKV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKV2"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="592"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="655"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="932"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1032" mass="111027" checksum="884828E2B3B63D47" modified="2022-01-19" version="1">MPSILNLKFKGNKSFVAFSNLGDAEALTKTWKVCTKVAGYLEQGQRLENLSWRLWHLQNLMVDTDNAKSKREFKKLSKCMSDKLDKEKGRAIEELEAPDFKHNPSSNMIRQRAVEKERNREASQNAQPGTIKRMQFTFSIDQPTPVSAQLVKKPDLKPSPEFNKRPRVGARQNAGEHRLDDDNVNTLLDDANDKDPPLTQRGRKSQSSSSSSDSSPSSSSASNKSSSSNTSVDSQSLRFPSLFSDDFGPSALLYPSPTLKNRMNYGEATAPHDNDQDGFSIPRPTIELPLDELLSTVDSPRPWSPSFFSTSHSDSQNRAEDDKDCSLGNNVSFNPNDPNSTFFLPNIPPYHQNDVIMQSISISDDSNNADDHTMTFSDLISTHNANHNSLTTTQPLTLHPASFSNSYNQPDTSDDSSASIDSDDEASEVEMSNATGSPSSSKSQAISGMPTPTPSTAVNTATPTPTPTPTPSASLTASMGRGGRFGKNASIGRGASASVGRSGRGSTPRPHLTVRTSSSVSTRSGVVLGATPTSLNPALLRASKDEDEGVGSSSTATTSSGRGTGGSVTAPVGRTGAGASAMGTGPGGQKAECSNCGATHTPLWRRGLNDELNCNACGLYCKLHKRPRPKTMRNTHGEGRAQTQPRPETVDVMAQCYNCHTTATPLWRKDDEGKTVCNACGLYYKLHGSARPISMKSDVIRKRSRHDARRGGGALAETPSASPGVSRRASPARETSPTLAPDSSTSTTPPQMNYQYPENVEYSSQSSELLNALGQDMGQSNTNDANNQSGSAFYQNMFGFQFPGPYHPDHLAQFVMQDPLPFASAEFDGLDSSMSPRSNKRRRMSTDSASEPPSSAVSFTSFDGYSSATSATSHSQRSSVDYAFSSYPASTPTSSYTPFAPASLSGGGMHVFRGSSNTFWHPPMTLSSLMGGHGNHNNVNNNSPAYHPPMLPPSEDSPMDYLHPPLLPHDDDALFSAYLHPPMSLPEEGQTKGQSQQQGSPKQQGQGSTQGQQQSQGQKGQNQSSGQDYMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL64</accession>
    <name>A0A8H5GL64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding protein Kin17 WH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL64"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="35247" checksum="201BC8BCAD48AC54" modified="2022-01-19" version="1">MPRAEVGTPKYVANQMKSKGLQRLRWYCQVCEKQCRDENGFKCHAASEAHLRQMLVVGEHAGKHISNFSSEFQSTFVQLLSRRFGTKRVRANQVYQEYIADKHHLHMNATRWVTLTEFIKHLGRTGVCRVDETEKGWFIAWIDNSPKALAKQEASLKKERATTSDEQRERNLIAEQIERAKAEAEQQAGPSRSSDSPPAEEGLKRDEGEKVVFSFSAKPAAASESAEASTLTTESKPIGLKMNPLKPTANPLKANPLKANPLKRPNVFKTGSATASTSGETESKKRPAPMSAAERLILEDQERKKRRMDRESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMJ1</accession>
    <name>A0A8H5GMJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMJ1"/>
    <dbReference type="OrthoDB" id="3218065at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="420" mass="46935" checksum="EB5542DBEE05F124" modified="2022-01-19" version="1">MPTKRQKQLKERAAWARAAKAKKQEASNTPDSDEETDDDDEICDWDGTVNHIPESDSSEDSDYVWNTTDDGTDSEFEDADGSAEETRALLQTEVEEEAAVLESLQTLYEKVNGQAGKMSNKEWKKAETQLKSGVYTGTAKRTQYLHKAKALEKSKEDASLRKSAGADMMRNFFFIKNPAPAPPAAPNPSTSPSQPPLSNSESRVTESEEIFTGYLSDLVSDDGYESEDDENDENDVPLPSESTAGSSSQPDTPHAPIPQDFGVRNLPAPKRRKLDVSVLEMRVKKREARRNEWSAALTAIQKLNRSKKTTFHAGRHSLQDYRARAIESTLTMVVKRNERFVPASSAAAAAHGFSRGWGGRMVRVWVRVWVEKRELPTSDRGCHAKVFSLFSDPTLCAEIRSYLRSNKWSVNPEKLAKFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNE5</accession>
    <name>A0A8H5GNE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNE5"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="832"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5368009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1260" mass="140478" checksum="C2E51DA06DA0D8AB" modified="2022-01-19" version="1">MAEALYEPYAEVLSVAQSNKDDLEALFDPEQGFAPRMRKICRDQILAYEETGEYSDELELMRLEENTWALLQAVMPARKTEQSVLNSPRDLLQQNPYTPTSTIAQAIMGASPLLTELVVIREWLQETAPAPSHPEATTGYWKFTKHSVMQALRTGAGSRDGLVKEMDPDAVNREDGRSLAADDASYEKNLAQALYGMVRAGRLDEAIELCRRAHQPWRAVSIRGSLFFHWKAISNENDFEDEEDADMWSGNRNRKLWKSSCTRAALNPALPDYDRVLYAALAPSPQTSLILKSACRTWEDHLWAQVSIMCEEKEMMELLRLGGSFWEGGLAAVEKGVRSVSQETVEDEEEQWEKEVHQALDGLKSVHVEDGPAADHPFHFSQLNIILDRSSYLLDIFANGLQNGSYDVVAYEYAPMCRFFAHLCLYLKMIDIPVPPNSAVIILEHYLQVLEAAGQRDLIAMYAGALGENAINRYAEFLVSLELASDPGERRLALTRARDHGLDQDSVATATAEMSMNKAFEILPPLKGPLPSVIGLQPPPPDPETFLLRSIEWTIFSETTYDRALEQANHILRYFLASGRIQLAQKLLSLLPVEISSIAEPEEQATEYLHYRQFFNIWENLERVTECQALEVPKMNRETRNSWLADYKLLIDQARELITKLLTSEWLVSDVETAGVDARRRALIRIRQIYVPELIIRLHFTLFNSRHHFPDNLNLALKLSNIVADSRYKLYEDFNNQSGRRLGDYLEAPPAPSSTYRHFMMSKHSKLRLALLRLSLTFSLIATSRAQAWQEDPPSAAATKACQILNKTLPGLVFFPGAANYTSDNFHYAATSTQNSTCTVEPLTNEDVSAILKIVGQEDVRSPFAVKGGGHTSNVGHSSTTGVMISLVKFDQITANDPSTTVTLGPAATWDQVYAKLEPLNLTVVGGRIPGVGVGGLILGGGYSWFTDQYGLALDNVVSYDLVLPNGTFVRVTDETEPDLSFALKGGYHNFGIVTSFTVKSHPMNGIWGGTLSFSANDSELVFSAVEQFSANNTDPKAVLTLTYNNGVMGPSLVANVVYDGPVEQPPAVFEEILNLPLTGNTAKARTLTDFTLGEFQFLVVPQTGFTQHVIPTLHYTVPIMRTMKIQVDAAVAKAIAEERSIATVGMNCEPYINDFAHSVDSAYPHSPSRPVTPGNPLSFYNDVADREYFEQLIWEMSEAIHAVVIQEGQGLPDDIHYPNYALADTPVELIYGENLPRLREIKERVDPTDVMGLSRGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPB9</accession>
    <name>A0A8H5GPB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPB9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="19130" checksum="0A68896C734C7220" modified="2022-01-19" version="1">MSPVTHEASSSIVQGALAWLLSHPASAASASFLVLLVVLLRRRYPCLTLPALEKSFKRLEDAIQTYQGECPQHYYHEFHDGFLILRGDVRSLMYTYFYGHWDPVWTLRYWKSRMDHIREVVACYERCEDMHRSIQHAIKIYRQRQDSLLLGFYNHTEASAYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQI8</accession>
    <name>A0A8H5GQI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQI8"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="334" mass="37105" checksum="7B268A93205BDE4C" modified="2022-01-19" version="1">MTSTLSRTFTRFSRRAYSTAATTLRRSYLYVPCSSDKLLDKSRSVNSDIIIYDLEDSVSPVPKDKENARNRLQAFLKTTDIPNPERIAVRVNDITTPFFRDDVDQILRSSSVQTLILPKIHSGEDLDYVSSSISTALSASSREKPLRIVPSIESAKGLWNLGNIAGWKTKNVSLNGGVVSAVLFAAEDCKSFLTRHCADTSILRTRSRQELLYTRSQIAIAAKAFGLESVDMVCVHYKDLDYLKEECEDGRRLGFSGKQAIHPSQVDVIQSTFVPTEKEILRAAKILHQMKAAHASQKGAIGLDGEMIDAPMIKQAEKIVNIAKAARLEIPTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR78</accession>
    <name>A0A8H5GR78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR78"/>
    <dbReference type="OrthoDB" id="3217643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="43986" checksum="E283EE92A8F686C2" modified="2022-01-19" version="1">MYTALPPVLLTNPLSRCPHIREVCRNRTYHPRIDVLFLKNAEVDCFNGCGYCKWARTNPPSKSAGYNNPGWPGCCRPPAPTEHRMIQLAEWKSVSMIHHVPIPPEVKATLDSLSACKPSPAPSSTAARSPTSPRPSMPVLDRKNSAGGSPPTKSSIVPVRASGSSLAAKSRSGASPKLAAASLSGSLSRSTGSTLSSSSPPMDQIGSRRAPISDATDKSRSTHHSPSRKQPDLDNSATPRRNSASRSSTSPSTPTSKPTPETTRTITGQSPERRRTTPSSAPASSPTVKTSATSRPSTGDRSAPAATTQRTPKKDDNMSSAASSAGSESRSSDFSDSTITSDGGFTDYLSDESEAELQRQAEAKAALIAQMQAEESEFKAARQQLAHVDLRPPKSWTPTNITNNTARLAQASGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRX1</accession>
    <name>A0A8H5GRX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRX1"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5369868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="66" mass="7706" checksum="96E768FAB2B86D4C" modified="2022-01-19" version="1">MSLSTTVYNTIFKRNSVYVATVFTAAFAFGISFDTGVQSFWDKWNQGKQWKDIRHKYMQSAEDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRX7</accession>
    <name>A0A8H5GRX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRX7"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="61" mass="6734" checksum="2CA1AF50905BBB7F" modified="2022-01-19" version="1">MAGAYFSIEVVPNALAVISLNTMYFYDSNSGKYHLTVLWEDAAITSPRIQAIFSSIGWKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSN6</accession>
    <name>A0A8H5GSN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSN6"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5370165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="19247" checksum="FE273301C42DC2A9" modified="2022-01-19" version="1">MASKAAAVAVDFTRIYTSLGLGKETISALQAFRKRYNDAQLTNGQNSQQPTTVDFAHYRSVLKNKAVVDELEKAFKEFKPVTYDVDAHVKAIESFEAKAVSKAKETEAKIDVELKELQATLANIEDARPFDQLTASDVGNAHPKIFETVETMLKKGKWTVPGYKEKFGDLNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT08</accession>
    <name>A0A8H5GT08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT08"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26291" checksum="7A8B804E81EBC66F" modified="2022-01-19" version="1">MTILKMEMKDSLTVQAILVQTLISVPFPKSITIVGKTMTLVLTVLSYLPVQPFSVSISVTYHFHHPHLIPLSFRYQQPHFDMHRAEQIHQAATIQDIINAHGLLQEQVTTFFQRINQQQTQPQPQAHTISQNSDKSSMAKPESFKGKAVDVRSFLASFRNWAGEQRDIAGNEGKMIRSALSFMQGEAGIWAASYIEEAMAYDGTAQTVNPFNGTWSAFVEAFKAQFGSLDEQADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTA8</accession>
    <name>A0A8H5GTA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTA8"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="144"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="46495" checksum="4DD762DC146113E5" modified="2022-01-19" version="1">MVLGYRHQPWKGLYLCYDFLGTLFVRVPLWFLFSIPRSWRPRFSWSIKQTLLVQIFRHVVVDVMDQTGPIFPVPDHRVLKDGPAVNGVWIDPVPDDLIVGRLRTWAFVASVSPIRVPGYWYFKNNDHKPMPTDPVSPGEKILYTFHGGSYISESSSPSGISTNIVRGLFQHVDKVTRVFAVEYRLSTTAPLEPANPFPAALIDALTGYYYLVHTCGISPNDVLISGDSAGGNLALALTRYLVDYSHTFQSLYPSLDHRSPSHSIIPGSLLLLSPWCDIGLSHDVPRSTALLVADFDPEPQGMDYAKQAYVGPFGMGAADMNEYISPSSRHPYFSASFKHFPKTLIVAGGAENLLPQIKLLRDRMIRDIGNDGEGDGKVVYYEAEDACHDFLLFAWTEPARSDTWQVIARWLEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUI8</accession>
    <name>A0A8H5GUI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUI8"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5371140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="23644" checksum="B01881C7EFD0014B" modified="2022-01-19" version="1">MERYLIAAGGPKTSSSPFKLLPVLWKPMSKSETDAAKRILGNASDELKRDIGTAPFGNRSDSRTFAGSVANRVRVDEIWLLPDPEEKERWVAKVVCGMTIEEDMVNTMGNIHGACSTFLIDMCSSLAILALAIGKYNDPKLAMVVSQSLNTLYHAPAGIGEELRIVNTTMTLGTRVTSSRTEIWSKTHHRLVSSGIHIKMAPTSKPEDGDKLKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVL9</accession>
    <name>A0A8H5GVL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVL9"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="412" mass="45615" checksum="D029830772D02310" modified="2022-01-19" version="1">MIESGIGAVRFVPPPLLRSSISPTFPSLRRYPTSPSSSKSISPSVPWLIGTLKQKSSKMQVSPAIVNAWGLARTAKGVSTAFNKFMHTLLGLYIWEWFISLPFDWHYVSGKKTFRWPLIFYWLNRYSLLFALIGIAIALNVQTEIDCQSLYTFNQVFGNASIGLASINFSLRTMAVWGGKWYVVGPLVLVILGHWSLLLHGILLKAVYVPGQGCAIIDTDNTLLAATFIYSMCFDFVVLFLTAWKLVISAPSSKVMGRSKLVVLIFGDGLIYFGIAFLANLLATIFMLLNLNPVMSIIANVPSAIASTIMATRAVRRLALFTSGGPEMFSTTQASTIAFRTSSKATHVRPRVNTGTVDGVHVQMETFESPTTPKKYVEYDAMGNIVNKDSPETAHFDPEAQEIRDEFKRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX28</accession>
    <name>A0A8H5GX28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX28"/>
    <dbReference type="OrthoDB" id="2960749at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034030635" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="13320" checksum="EDAF8B56C66578FC" modified="2022-01-19" version="1">MFFTKTLIALFGVATVAMANPVSRQVGPTTKCFFIMTPTPDLGPDGLQTDINFAIGHTLGVNFPNTPLQDDNEPLVRHNDGTYDVTSVISVEGQSAEDVGAFVESWAGTTIDGIDAEWAVGAANCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYA3</accession>
    <name>A0A8H5GYA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYA3"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5373180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="42734" checksum="85987A1518E76E8D" modified="2022-01-19" version="1">MAEAESNSKPLIFRWGIISTGAIAAAFAKDMQVDPKTRNIHDIIHKVTVVGSRDVSTAKKFVDTYFGDDNNVNDGSGKPKAYGSYQEVYEDPEVDAVYIGTPHTSHYTCALHAFTSKTPKHVLLEKPITTNAAELRSLIQKAKENNVFLMEAMWTRFQPLVMEVKAINESGDLGRPVALQADLSGDFDIENIPVTHRILDPHLGGGALLDLGPYPLVWAIIALYEHPLNDLKTPTVTGSMLKTPITGVDSNTSFTLNFFQSKIVAQAVLSCNINVDATDPGVTIRYEKGEIRIRKPIYCPKEFEVEYREKGKVMKVVKRRFEYVGGGWHFQADEVARCVRDGKLDSDTWSHQKSLLEMEIFDEVRRQCSYGLPPGVEKVVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1E5</accession>
    <name>A0A8H5H1E5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1E5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="128" mass="13752" checksum="7E202817B57C629B" modified="2022-01-19" version="1">MDMNPTTSSMAFDVDSVVYPTVKQSVPLLSSLSLGKNITIKEPSDEPMEALVRAASGMNMGQADEPVSTTNSAAKVEDSDDVSCKEPMFSFGSCSSGRESGASNLKEFVQRPEIYADPELLEIVPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1H6</accession>
    <name>A0A8H5H1H6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1H6"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="897" mass="101068" checksum="AD236A018ADB4EC7" modified="2022-01-19" version="1">MSEDDRAAKAARAKAMLKKRQAKKGGPAAATSPGVASPTSERAFSPAPPEQPVDEEKRDLGDLFSKDDTTEPTSWLSSLTRVETSPPPPTHNIPAGSGSNGNDVHQLLSSLQAENESLKREVESLGAAKIELQQLQDSLRSDHAALKAQINELQSANSKLQTDEKSLTSERDTMKGQLSQLESQLQATEASLNSENAKLRDSLAKLEASNIQFDHTVASLKSERSSLEDKFRGELENINSQLQQVQTALQVEQARSEQLQEQITHLETEKENSQQTISLLVSEKAALVSDLERFSDVESKAEDLERLLSEEQTKTGSLEQHVEQLRSEIRDATARTERQLQLANASVTSLRNESEKHQRRVKELEEQIESDDRAERLEVSLKNTQERADELEFQLSKLKQIHADLKKERDDIQSKLQTQDDQGKHWEVQHSKLHEQYVSIQQQLSDVISEKDALIEEKSSRQLEIDNTQKALSLLQEKLSQAANELASNTRQLQTAHNEAKIAMRRAEDAERMQKDLQTEGTNLMRSLDEMRPKVVELTDQKLELTEKVDELERVISGYENNISELEASLEDAHQEKEALDNHWKQVISEREKDKTSALDSSTELQKAYSDLQEELNSALASVKTLDADRTRHQQEAARYLQELEDLNERSAAQKDELLKLRQELAQRSTEQEEEQDFLERAQNEIETLRQELSSKEEELQRLRSPIRTEAPRSLDDEILSSVKQQHSLELSTAQSQIRSLETALFDAEARSHTLTKQIAGLEDQLAARPPVRSFSPGIPSRPSSRGARNVAEQRPYKPSALSRPAFEQNLSPETRHKRKTSLSMLKARMDSELAVAAAKANVTSSPNSRALSPVSELSSEKLNRSMSNLPHVIRPQFLDDSHIFWCSSCRGDLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1S2</accession>
    <name>A0A8H5H1S2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1S2"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5375199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="23847" checksum="A3E8B637A4F16437" modified="2022-01-19" version="1">MSSKQANRQAITLKGSTKTVTEFFKYAVNTILFQREVYPTEDFTMVKKYGQTLLVTQDPALESYLEKILKQVEKWLLTGSVAQLVLAIVSKETRTPLERWVFDIKLIEQPPDSKERAPPKPEAEIQSEIRAILKQIISMVTYLPVIQEGTVFNILAYTSEEAEIPAGEWVDTDPLAIEAGKSQQVKMRSFSTDVHRVDAMVSYRYEPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LET6</accession>
    <name>A0A8H5LET6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LET6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="12319" checksum="6AA55800D9865A25" modified="2022-01-19" version="1">MEDTSHSFSPVDLNMGKPTRQSVLRSTSQTKWNLSSVPNTSPDDGPKKVHLLKTSTLESSMARAAASAAAAEPLLQRPSSPPPRATQTQTHAPSASISNRNATPVTSRQPQARHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHB7</accession>
    <name>A0A8H5LHB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHB7"/>
    <dbReference type="OrthoDB" id="2758707at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034998017" description="Hydrophobin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5357485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="39996" checksum="E3CA8D33FDF8D774" modified="2022-01-19" version="1">MRSLDLLFSLYVLSSLRLAAATPIQQIAERQLLPTSLPISLPISLPTSLPISLPISLPTGLPISLPITLPTGLPISVPSDTSAQASTTEESGLPITLPTGLPISLPTGLPISLPPGLPISLPTGLPISLPAGLPISLPTGLPISLPTDLPISLPTGLPISLPTGLPISLPLQQIDERQLLPISLPTSLPISLPITLPTGLPISLPSETSAEASTTDPGLPISLPITLPTGLPISLPTGLPISLPTGLPISLPTGLPISLPSETTTDPGLPISLPITLPTGLPISLPTGLPISIPSLPISLPIPTGLPSVCSVGDLQCCAVVTTPSSPEGANVLDALGVVLQDLNLGIGIGCQSIDPIVGATLCPTTPVCCEDHNFGAILEVGCTAGGLGGLGGVLGGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIR0</accession>
    <name>A0A8H5LIR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_004739</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="434"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="1418"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="1664"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="820"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="970"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1292"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1516"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1860"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1951"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2013"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2370"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2640"/>
            <end position="2751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2528"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1521"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1556"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1586"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1629"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1873"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1973"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2013"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2043"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2087"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2118"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2375"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2645"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2672"/>
            <end position="2685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="2687"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5359015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2751" mass="303274" checksum="1F02A7D36BC3B88C" modified="2022-01-19" version="1">MPFAECDKELQRVTNNITAFFEERLKDGEYDTDREFRDRDRDSQIGDADHLRDPCVFQPGELRSAFQVDESSSDGGYEAEMEYHSRHSRQRGFSDDDLYYSPVLTHSPYIPAASSTSSMSPGALRRQQAIPWERPLSSSMSSSVVSSSPASSTVMLPEVPLTRKPTNPSPATSSWSNQNPSSRRLSRSIHIPSRPSHSGQSSRSTSRSRSPLPPLHTHASFSDYNSAGPSSSSNNRRSSRILIDDPIDPIMTTLYELIGVATDIIEMSINQLTAHPKACEALVQRVQNIGKAWDEHPDWHGRNWYVQVLLALASLSRVVEWWEAEKSFWNFNDNDDEQEELLLFVMKPPDDAAEPVHPMETVPTPTTGKQDHELENFRLNPEENNLRLHRPASQSRRSRDEQPKSLTSSHETRPELHSRHPSKAHDHESARVLATERLRLQAETAQNQNIVLELSLDGDHLIWINYAWRVVVGTEPDEFFGTRVSALLHPADAQVFNAATSRLLADDSHTVEARFKLRVVPEDDREVPQGQAPYQQMEGKGMLMIDREDGEPSHTMWVIRPIAPQRYEYEVPYSQAVLPDVLSPSDVESPPESADVETEPPMESSLPFQTPICIQPILCRICECQIPQWYFEKHSETCVETHRLEYEIMECNESIGELRNTIRDLGALMDGSSSSPTPEYRGMPIFSPSSSPVISSPLQLFRANKMQRFGVKKMQRRLLDQLDDILQVAAEVSIPSLKEEEAKEPIERQRLLSPGSERKMSQIRNWSKPNIEDGALTQLVQDVERVMRSKIDNVVRMQNTIRYAEKIWNEWQERVGAYLNDEDSSGSESSGEEEEDNVDEGHDASGTPDALGLKLGSEDVIDDASSTTSEYAFTSHSSSDPTPMASSSPVPLATPLLISLVLVLQLRTRHTRSSTPSSISSPLARAAPIVAPSSHEDNVPAMSLDEPHPGRLTIQTRKSSSNLLEPKFIVTPPASPQVGPKDAPSGASGLNREPSMKRSHRRHSTVNPTMSPGGPLSPRQPSAAPLSRTNPTSIKDFDIIKPISKGAFGSVFLAKKKATGDYFAIKVLKKADMIAKNQITNVKAERMILMKQAESPFVAKLYFTFQSKENLYLVMEYLNGGDCGNLIKSLGALPEEWAKNYIAEVVLGLEYLHERGIIHRVLNAPTSDLKPDNLLIDQHGHLKLTDFGLSRIGLLGRQTREGQVSRPYTRYNSRSRPPSIDAAYLSSPLFNNDVNGSYFNQRTHPIPRFGSSPYLSSTDDVGEVSSDFGVQRRRSGKADSPLQSFATELTTDLRSHSHSNSNSNSASGTPPGDQKFVGTPDYLAPETILGLRGDDTAVDWWALGVIAYEFLYGIPPFNDETPEKVFENILSGHIEWHEEWVDFSPEARDFMQRLLVTDPSLRLGANGADEVKSHPWFDSIDWDRLTTEEAAFVPNAQDPESTEYFDPRGAVPMTFHDDDQIAIAAESSGASLESGSVSTPSDEFGSFSFKNLPVLKQKNDDVIRKLKTDQMVPLTETTGLHSRRKSISHRIKKPEKLVTTMEPSSKVIPTNPPSPATSTSSIASSPSRASLPPSTPGSAGGGHARKPSELGAVERFKHNQLEGLDRRNSMPSRLRTASVSSGGDGSGSETWNSSVGHGSMYTPPSSVHSIDLRKGPDPNDRAVTCLLAEDNPITAKMIETLLIRLGCRCVVVADGSEAISVAMGDIMDGEGAARYIKSTNSKNTNTPIIAVSAYSGVDQSEGSNVFAAYLSKPLNKADLIAFVFPLTSISSASSSLAFLSAIVFRTAVRYIYEGTEYIALIDAGDGYIRCVMSYNNTQASANGLPPMFAPQRRANSVPRPLHQHPPSTVHKSDIFFSNTHSEPTLTRARTAPAPIPPKPYAYYSEPPPVPPIPPILPQHTRPVPSDNAELQAAIELSKSESAQRAEYLNNLSSQEEEDLARALEESLRLSGSSLSAPPVPLFSHPSGSRPPRTIQSAPVSRTPSSRTHNGTASPSGTVSDCISDDEALARRLAQEEEENERLRNSGERDGRLPNMPSIDEDEAFARRLAAEEESKGTKKDEASTSPAITPSSFPPAYESSPSPPQTSLDVSSLVNVSLSPNRPFSDSLTPHRRPLSADASSTSSDFLSAPSSSVRQSTMSLPSLSEDREEDSSLPGVSANQFVDSELLVGFSVGFVAPVISHQQVPWQGVMPNIISLPYGKCPPLHVQAPNWRHLLKLMARLSGTKVEPSIEAIADKVEPILRTVVQVVRPHHTSPDWRTVLWFTIDHPIPANRPVPRKFANGDVEALPYSYTLNTTLPALLQDSADTAISKTFTVPATENLPYPVLPISFPNLALYLSAALEESRRYMNDSSSGIRKLAKMVDSCYPNEASPSTTTGRTRNLLGRVMGRGNKNNKNKGRGGNEETYELVTPFVPDEVASIRRTFGDMNNGNTKPATQESKTVPIVIPPLTQEEEDQVVLARITNEERPLKRVIKKFHNYTSVAHTPVVPLPSQADTDLASAVEDAREAFLIELASFELLLKKSALICEAEARQVEEYQREKEKIELEHGALRGQIEQLKIALENAQMLRRQKMEYDLVAEKVNTLPSRDELMQTIQSLENDMAAIQAEHETQNRTIQAQKAALDSIVMDLTSLRFMGKDRDVEPSSSASQRASPALEGSSADGLEDGGSASGQPSRLHTSTSAVGETEEKEEGEEGEEEKPLDSALQSENDIEMGEVAEEKFSRKKVREELEEGEATDASSELSEPPDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJX6</accession>
    <name>A0A8H5LJX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJX6"/>
    <dbReference type="OrthoDB" id="3235815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="74092" checksum="A33F64CFFF17A476" modified="2022-01-19" version="1">MEPKQILQIFAGRKWRKDLLDDCNRIDLSDRTERDAIRALIDEAAKSMHDLKAYRNSIASISYLPDELLSSIFYWCILETPWHLSNWRRILFVCHRWYRVASNAVQLWTIMDFDLSRGDIERAVQWEKRSKSYPLICKLENLSVSDGGRARIFSSVFIRNFYRVKSLQLEGDVQGMKHFFEDDPDLKALPLLQELHIRAHRSSEVPDWRLPDYIVNGGCPLLLHSLSLKCVTFSSEVLQRISNLTNLELHSISQLLTISELLGLLQKSPQLERVVVNGSVVIDVITPNTYVGDPVPLPHLRRLALVSSVRVLSILLSSIAIPPTTSLDLIINQQWDDGFIIPSLKSLVRAIRMHLHNPNSPILRSLCIGPRPHLDFGVEIVASPHRKCLLKPFRDITEFDEMYDKHHFYLFVESAEYPQPLVRSIITKVFDALPLRDIERVDVPSRMNDELTEKTWGMVFERLPMRPLVIQTGISDTMIAMLEGLFDTMFAYSEAGTNTSLDKRRRRAARKEVRRKEPGRSQSTVDPDDVAQAVGDCFRLVSDNTGNANQSSGASPPSAASSASGPGILSLELNSELHFHEELEVDRRQIPKEWFDQLFALLSEYRDSDFVGKRSGARVPMLVVKHYWPTEDYAENRFHQVVDNVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK20</accession>
    <name>A0A8H5LK20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK20"/>
    <dbReference type="OrthoDB" id="3267821at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5359933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="38341" checksum="484AAF2C13380086" modified="2022-01-19" version="1">MSIPTGTPELNTSAMSAEEAGSSADNGNEHLASQTSPTAQSATDCIPYQTLVGPMTLNLRMPPFPPRADTPTVSVAPPAPAHDLAQYADNLGRSLHLQKSQQEELLRATQIVDPNRQFIYMVAQLLFVKGSIELLQPASAPIAFAANLESKIDELAVMVILDPTAGAYKSRPTERIMAGIRCYPDILTPALRDHKPTLKALKAKAGNLCTHHRADIKLQIARSLGDFNSDIKLFIGPFVPIVELTTAITNEVNGRAAEVKVSLPLVARIAFLRNIFVSEAQQTSDGKVGAGYWDAVDKGLEFIRESHKNNKVQISGVFARILQDDRTKYQSDFTGPMESLDGLEDIAVDIIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLC2</accession>
    <name>A0A8H5LLC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 monooxygenase CYP63</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLC2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5361432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="67817" checksum="B06045DCBB395BB9" modified="2022-01-19" version="1">MVNGAYNYRSRFLLDLFQAIVLPGLVLTSLTHIFDIRLGLLYLPALIAVVPCWGITKGLIRNILRSRQQQVLNAKPIPCVVGEWPGNIDVLLRMTRAFRTSYILDVYLELFEEYQCTTLNTRILWTDSIITMDQEHIKFVLATGFNHFWRGKYQKERMERFLGQGIFNRDDEIWKMHRINTRPFFARERVSDFHTFETYTSRTLDIISNFSAADQAFDAQDLFSRFALDAASDSLFGKNLDTLSAALPIAGQTRMGPKGSATEDGWGSFAHAFEMAQQVVTNRARLGPWVWPLMEFWKDKNKENVEVIHGFLEPLVQQAIELKKKMAESGVTSPIEEKTFLQHLADSTDDPIIIRDQLLSLLLASRDTTACLLTYVVYFMAIYPDIARKLRNEVLEHCGPRSPPTYEQIRNMKYLRAVLNETLRLYPPVPLNVRESRAASALPCPDPTFPADVRPLYMPGSTPVIYLPLLTQRNKALWGPDADVFCPERWTEPARIAHFVSNPAMFTPFSAGPRICIGQSYAYNEASYFLVRLLQEYDIFSLAPGAQPQGSLPPSEWKGRRGRQAEERIWPGAALTLYVKGGLWVRFGKADSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLD1</accession>
    <name>A0A8H5LLD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLD1"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="6">
        <location>
            <begin position="647"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5361462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117692" checksum="B1059DA9A5243641" modified="2022-01-19" version="1">MNHNKSIMLKRGQEIGRTTNQRPDSKMLLNQSSRVLITGGYGFLGSRIVARLSAMEAGFIRVADSISEPPHSRNTQDHEFMLGDLCDEAFCQQVVWGIDVVIHITAIIDGIGYICGENDPAIQDKTMTMKLLEACVAAGVKDFVYASSVRTDANSLLLDSSPDVSLRVSDIAFQPDPQGLYGLEKLNFEGVLHNLPSTMNIRIVRFHNIFGPNGAWRNGQENAPAAMLRKAFATKLLGDTTPPFELGGIGDQRCSFLYIEDAVDGFMEILQSGKTSPFDIRSDYSVSIKELADIALHHADVDPSTVYFKFDEKEPVVVASPSTKKYEVLCELGWTPKTSLEEGMRLTGVWIQGEMQRILGDCEDEEQRWSMLKKWTDSDMVDLALDSSIIFAILLPVTSRSVGVESCLSNLRQFARSLKETTFRDTHALGGTRFCVKVYLALDSDDELLYIEGANKACEVLYDAGIRDVITLIRDYPKGDVCSLWRDCAREAWKDGCHYMVLLGDDVVPHDEDWMRRTHSQFKQFSKKSDVPLGFGCVALTDISFPGIPTFPIIHRTHLDIFNGEVVPEVFINQGGDPYLFQLYRQWGCSEMIPSRISNRIGGEQLARYQKIHVQWTFTTLDNGVCKIKDWLRARNRQIQRQLMLDVVIPSYRVLLPVLERILNLKTSATCSVMFIIIVDDPNSPAIDELKNKYGSSPDVRIRVNNENLGASESRNRGMRESSAEWILFLDDDVMPNSDILVQAEKVIGACPNAAGFVGRSLFPPADNIFTTAVHLADVLYFWDIANKISYDVPWGVTANLIVPRRKDDIYFDPIFPKTGGGEDIDFCRKKRDYSLSLGGEGFRAAPEVIVTHPWWNEGKRSYWRFHMWSIGDGTLVKRYPEHCYQQWIPNGAEMVSLCVLVTLAALPFARGLGQTILDVLCLFFKVLLAIVLGNILHDGYRIYWRNPERYIDLNTSINGWRFFLAIIEGCFIRLFSEMGRLRGMIERKEYSVILRRQRFDWFAGHPEFGMGPIQEELQNGRDRVLMVVVLLFWMMWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLE6</accession>
    <name>A0A8H5LLE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLE6"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5361419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="18796" checksum="10200559F49C5C0C" modified="2022-01-19" version="1">MSKALDYFSLESSKWKHLPPPPGFSKSVSSHKGASKTVTKTSPEEYDRLKDKRAWDLALSPAKSLPMQAFMLYMSGGGVQIFSMGIVFMLLSSPFRNIFGINNAFAQFAPSTATDSKSLTTLFLQKLAYIGCNLLTLGVGLWKCRSMGLLPTGTGDWLAFESRGVSPEISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LN03</accession>
    <name>A0A8H5LN03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LN03"/>
    <dbReference type="OrthoDB" id="2628419at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="81" mass="9137" checksum="F3DA588E318498EB" modified="2022-01-19" version="1">MTCWTVLTAGAYSFLFVHPIWSKHPIASLGAQIIWIFITWLFWVIAASIINHSLPSVFERAFAVLEMLVVDFAMAGSRNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LP71</accession>
    <name>A0A8H5LP71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LP71"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17650" checksum="3CF4EC0C0A97E8C0" modified="2022-01-19" version="1">MKPLLGNKYGALNVFLPSIKTAGDRDDHAHITPWPHVLNATKAAHRHVKDNDLSQSDPFTAYRDEHGDIKVLTRSKFMAMCNRIWTREEYGRFTGHSFHIGRTTFLLSNGVDTETVKRCGRWKSSAFTRYWQDLHTISKVHIDRVHAHCNLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPF1</accession>
    <name>A0A8H5LPF1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPF1"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="556" mass="62014" checksum="6171A199C4CF62A8" modified="2022-01-19" version="1">MPLMDPREEPMVVDTSSGSDTKHPVPNLKPVSRPKSRSLIPMEVESSSDSDPAPEIQPNPSGTRSLLRSLTPIEIESNSDSEPISQLLFKRSGSHSKTSSPSHPIPLYVKSGSESEHMEPTGRTRNASDSSSSESGEFLPFRSNFDRANLPRIPVSSAVPGSSSKRKEKGKARETDVARARGQTRSSGPYSAPSQTEPFVTARVPRTAFGRARRVLASPSAGRPLATVSMRADIQFFDPEKRISTFSLPSGNLDTVRQVEDACAIGDTIVLAYDHASDFQVSCVSLPENSRASRPVLVDLPHTPHQPRLSEPPEDPNVSRPSIPKLIRCITPGPDRRREFLTSGYDKILRKWTLDPNSLHHTRSEKILVLDRTPAVLACHRTTLLVGFGLYVQAYDLNRVSTSTMIYSEKAPTSRMSNTIQHLYFHPDDHRMQVFEVDHLDTQVHVYDSRKSPKDKYGLLYDRKSDCSFGYRAEQVAGKPRRRFTEGSTKFCYFARGYEDGMICLWDYRNPKKPVATECKRETGVVHTLCMDDHFVAFGGDSLTFMDFSLNVLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPH5</accession>
    <name>A0A8H5LPH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_005530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPH5"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="191"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="428"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="876"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5364658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120430" checksum="CCCACC4EA492B5A0" modified="2022-01-19" version="1">MSTITANGASSSNTTSSFLTALVVNGALLGIEVGAFLVMKTTLYRIFSARTYLPPPAKRSLQLPKGLWKWLPAVIASPSEEIIHKNGLDAYMFLRYLRLLIKIFLVFTVMTFAVIVPVNYIHENGARSSFERITWTNLARPEDQPRFAAHVVMVYILTFFVIFSIRSEMSHFVHMRHQFLLSPSHSAHAQARTVLLTSVPDELANEHDMRQFASFVPGGVDKVWIYRDTKELNRLFEERQDACGKLEAAVASLLKDATAIWRKRAKMWEKKGKKARKAEKKKAQEDGGEKDTVVSVDVDLENQEDGNEMVVPPPSREFLDELVPANKRPTHRTGTLGMFGEKVDTIDWCKQEISDLNIKIQQARAHLVEGKPLGSVFILCNLQMGAHILAQCVSYHEPFKMIDKWIETHPKDIIWNNLDDNALEMRWRHLVSWLALIGLILAWFFPAAFIGTLSNIDSLCHDVHFLGWICRDLPHTVQNIIQGFLPPVLLAALFALLPLILKTLAWYGNIPRHSLISISVYRRFFIFLLIHGFLIVTITSGLTEAIEDIINNPTSTLQSLANRLPGASVFFLSYMVTQGMSGAGMALIQLMPLIKHYFKKVFLGRTPRQAFAVTFRMPSIDFGETLPRLSLLATIAFAYSVLNPLINFLAFVSYIMMYIAYKFLFLQVLDQPDQSETGGLYFPMGISNLFVGLYIEQICLACLFFLKTSNSTSRTAALAEGILMVFLVVITAIAQSTIRRSYKPITEFLPMSLATKQMAERYAHKKRDKHDGDDDDGEVMDLFSRHYITSVRRRITKFPKAIPKTIGGTLGTIGTITAKAGAKVGLAVGISGFSDEGHEQHELQPRGSSSPPSSALIPTTTTAAGPSGLLRPSTEMGHDDDHISDHHDETHDEHRELINDNATACPPLTSRPSDRGSTSSFTMQSFRPSIPLRLSRPPSFNNVSDHSHYEELKSPDQDQGQSLPPPRPFLHHLGTSNTSRSRREKGESVVVPPPPREEDEEDLDDHAFDHPSTYVEQRWIWVPKDRLGLSKVIIQELKDAGVEASDDGATMDKKGVVEVTRNPPDEVWEDGHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR62</accession>
    <name>A0A8H5LR62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR62"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="17296" checksum="FA9512517270060B" modified="2022-01-19" version="1">MSSNNLHPIRKSCQQYVEQIASAPQEKLESTSAQLIVVGCGDWQPINFYADTTGFRGKIYAEPTRAIYRELELISNLQFAGENMPSYLKRGRVSNALQSTWKVIRNRSLIGKQGSTTQNGGEFIFEAGRKCTFAHRMRNTEDRKSSLRALKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR75</accession>
    <name>A0A8H5LR75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR75"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="259" mass="29556" checksum="63DCC0AC04980E20" modified="2022-01-19" version="1">MAVTQSKPIVFYDFISRDPKTRPCNPNTWKARYCLNYKGLAYTTIYIEYHWQDVEAVCKESGIPPSRTNPDGTPKYTLPSIIDPTTGTAVSDSFRIAEYLDKAYPETPVVLPPGTRGLQAAFVEGLFPKMLPLIKFGMDPTASKFITEKSEAYFRRVRGADWGPGVTLKDIYPDTQEEKNVEWKNLEKAFEGIGNWIGQENKFIMGDRPTFGDFALAAFLWWARELWGEDSEEWKEISTRWGEGRSGKMLENLDQYGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS25</accession>
    <name>A0A8H5LS25_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS25"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5367970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33888" checksum="C84C0687FAF28E6D" modified="2022-01-19" version="1">MEDFCSGSFSACLPGLSFAIISIIKGFFCSWHIANEIILPIVDILDNLWPIVILNVLITAYSIEAYDTPPLHSPQDPLIYAVCSLTTHVTRASYPDAHLVEILPFLNDLPQWIPGVNWSNRWKKEAGDAYERYTEGFEGIYGKAEERVRREGENGDRDENGKNEGKGSFARKLVRHKPPTPIDQDRSSLVSGEDTVNTMAWLLIILAKYRDVQAKAAAEIHAYLASTSISTPTSTNASASASLSSPLCLRLPTPTDHPNLPYCRAVLHESMRWRPVDPLGLPHMCVEDDVYVCADAESGASGNRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSI2</accession>
    <name>A0A8H5LSI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSI2"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="60151" checksum="A806E4425681B179" modified="2022-01-19" version="1">MATDWKIIAAGKKAQQQASIPKEWLLSNLPPQSVLDISGFPETCGLLSDEELQITRSDTDTLLAKLASGEWSSVKVTTAFYKRAIVAQQITNCLTEIFVERALARAAELDEHLKKTGKVVGPLHGLPISLKDQINVKGIDSCMGYVSWIDKPAESNAVLTDILESAGAVPFVKTNIPQTLMWPETYNHVFGRTNNPYNRSLTSGGSSGGEGALVSLRGSPVGVGSDIGGSVRIPSAFCGTYGLRPCYGRVPYAGCVNSMEGQDSVPSVLGPISNDIAGIKHFMKAVIDAKPWLQDPLAVRKRWSEEEYNLVDHGNGKNLCFGILWDDGLETVKKALLDAGHKVIDWKPLKHPEIYETLRGVWGAGAEEDYRTVTALSGEPIISTMVPEDAIVKDSGEWFVVDTGVSAFQLWQTQKHKRDLRQEYLRHWEDTVSVTGTGRPVDAIISPVAPYAAPPHGLNKNANYTLIWNGLDYAALVIPVSKVDQALDVQRPRNQFYNDTDKALYESYNPETFKNAPISVQVVGRTLEEEAVIAMSEIVDNALKTSKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV72</accession>
    <name>A0A8H5LV72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV72"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="43"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="42262" checksum="8D4B04BF54EA5866" modified="2022-01-19" version="1">MTLLISTIARRLYSSSARKPLTVLAFESSADDTCVAVVTSARQILSNVVIKQHDVHESWGGIHPAVAVMAHQRNMPIAAKRALQEAQIDISQVDGIAFTRGPGIAGCLAVSCNAAKTLAAIHDKPIVGVHHMQAHALTVFLTSWPDTPSFPFLTLLVSGGHTLIVLAKSLTSFEILATTGDESIGRAFDKISRMLELKWDDIGPGAALERFCASPESSSLPDGFIPFPRPMKGQLAFSYSSLHSHLERYLHFNGGIGAVTMPSRRAIARTFQLAAFAQLEEKVLLALERCANRNLNIQHLVVSGGVASNSWLRERLNICLQSAPNPVSVIFPPPSLCTDNAAMIAWASMHRFLEQDYDDYSINPLAKWSIEDVEQAKNLTEDYPQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWP4</accession>
    <name>A0A8H5LWP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWP4"/>
    <dbReference type="OrthoDB" id="3060478at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="453" mass="49507" checksum="476775B3116AE07C" modified="2022-01-19" version="1">MSDPAQLRPHYIAFGVQCQMIPKTKLIAKSEFEGIYWEHRDLFVVQGEQLKYMGLYSCRSMTHIAPSGIPLFSPWNVASTTSELAKATRVEQDSKKIPPVDVLKSMYTRGELKVECIALQAMGFNQKLYEILRKSYRYNLGMERIEVQAAARSTKRVRSPSPRPAMGRGQGNGAGSQRIGSDVRGGDADVGSGSRKKKSTTDKVLEKGKGKAARVSQASASDTTSDSDTDSSSSPLNFSSGNTSLHKAKRAKLDDPCRDGAPGPSGSHKPTVSDSDSDSESSDSDTRISTIKQSRMRTPNQPQCEANPTKILSEKPRQFSDIPSWTTLPDSEHAAFGNTPSSSKQVLKPVKIIVIDDSDDDGSIQQSSPSAIPPRRSTRLTPKREESTDQPLALRSSLTAPIHSDPAAKEETPEISSSQSLPNTAPSYNRLASIYRDTPFYERPGWVPKKQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX63</accession>
    <name>A0A8H5LX63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_005285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX63"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5372636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61418" checksum="7E280F2C4CCFB3B2" modified="2022-01-19" version="1">MKTLFSIPGLLLSLCTVYVARRLLELRKGKLPPGPRGLPIIGNLLQLKLDAWLPFTEWKHKYGPLVYISVGSQGILILNSHKAASDLLDQRAHIYNNRPRFIVAGEYLTGGKFLGILQNNDLWRRMRRAGNEVLNKAMAPSFQPVQEREALRLVWNMLQSTKPQEWDSELKRSAQSLTLSVVYNLPTLESANDPAIARINEFVLRLTQATFPGTYLVEYFPWLKYLPAFISKWKSDAQMWFRRDTELFRGLYDGVRDRMIEDEDANSFTSHVIRGQERYELSETEIAWLSANMYSGGSDASAITLEWFILAMLAYPEVQQKCQEELDSVVGRSRMPRFSDQEVLPYIRATAREVMRWRTIAPLGAPHQSTEDDFYEGYYIPKNTIIMPNIWAMNRDKDIYGPDAEIFRPERHLDPDGKLAPTPPDTKRKSRDNFFDILANSWAFPLTEGNISFGYGGRTCPGKHVANASVFINIATILWAGNIFPEKDMEGVPVKPDLSDTATINNGIAVRPFSFKCLITPRFPEVTEVLAQTKEVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXG2</accession>
    <name>A0A8H5LXG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXG2"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="254" mass="28238" checksum="226BD8E75D084CCA" modified="2022-01-19" version="1">MTSSTDTGNAIAATIDAYISSFDAGRGDNPVSTAQKITSTFLEAAKTGEELPEPWAIYQSIVSRIRTTTHDSLTQDNLVKLVGAIKETRPEPKEDYWSSLYPLGLYMRELWNGDYPATEWASLNAFVARLTVANVLDFQLFGIWAMRSALENGPAEGELSNDVLNQQIPAAAVWIFYAGSKLWDLSTKEANAGETAARGGQKWQGTWGYNQPRWVFWKMRFEGFAGRKDLRQDTTTMAKKALEGMSKVDETVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY91</accession>
    <name>A0A8H5LY91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_000586</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY91"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5373776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15171" checksum="C5EDCBB64B376041" modified="2022-01-19" version="1">MAPKPASTASKAPASTAGKAPAKTEGSKAAKKTASKPAADGEKKKRKKARKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLATYSKKSTISSREIQTSVRLILPGELAKHAISEGTKSVTKFSAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYN2</accession>
    <name>A0A8H5LYN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYN2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="262"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="819" mass="89187" checksum="9D894EB33DB91AB6" modified="2022-01-19" version="1">MPTNANDNLIVDLGYAKYQGVRNETSGNVRFLGVRYAKDTAGPLRWRAPQTPDSASDADADGDVQIIIADTQPPECPQAPIGPTSTSSSNATQERDKNVVESEDCLFLNVFVPGSQFNETEASGPKESLPVIVWIHGGGYHLGSASRAGFLGATGGYDGEDILQIGAGREAIVVVIQYRLGLFGFLAGSKVKEGGDLNVALHLQVHWRLIACGHLGRIRWSAAFFSFFRSSLFNNVFRRNSTHPPSTGQSYANLINQLEFEGGGSVLHHLTANDGQTNPPLFHGAMSNSMYLPPIYPHNDTMPETIYSLATQKTNCTDASDTLACLRGTDLSMLSAANNEIAQYPFFGQLILSPIYTPVIDGTFITRRPIELLAQGKINKVKKILSITNSFEGTIFTDANTTDVVGFIKDLFPTLSNETTEEVAGVYANPTMTTAEMAARIYGECVPPAFHATDIPYYWTSISSPSLPVFQNADFQKAFAQSFVTFTTSSELDPNDKFDENILPEWPLWIWANATEMVFNRTEDFQPLIKTVETDKGVLERFSGEISARKPISRGSTPLSINRASELRAGYSLAYQKPNEVTNTRSKYEWFTDTIAEDSAGMEFDEALSRLPGFVEEIQVVIGNNRVTVNAAPRTQQFQIGDNSSMRALVQVQVQFHLSSDVPKNCDRVHDSMVEVSVHKLTSPKDGIVALKKVVQVHRSFPNQQLSLIMQFKFFTVAALASLAAATPLEVRQGFSQCNVGELQCCDIVQPASAQPASTILGLLGIVIQDLTVLVGINCSPISVIGVGGNSCTAQPVCCENNSFTPLIAIGCTPININL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ00</accession>
    <name>A0A8H5LZ00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ00"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="656" mass="72739" checksum="0D81899746772A98" modified="2022-01-19" version="1">MLLVWITSPAKEYELDLTAIMFVLSPTWILWDADLGWQSIEIFITNEDILKIAPDFGSLLVEDGGRHDESDTDPLWGLFNDLCIKELKHNRPSNKQPAFYISQKGTILERIQQRFMICTRCSKALSRVPGAYQDNKSWWSAISYLYYAEEASCKTAQDCMCKEVVEEEEFRCVCSRDVHTPLPKVGLGFGKKHSKWGLGMFGSDKSHHHDLPPVHDIPAASSSTGSLKRTQSAGSDSRSIRGEPSSLQEPMGQDEVKKFNKMEAERVRHEAEKQRRALAEKMQREQARAVMQKRNMIMQPKIHAKENIEWRGGSEQPRLEFTDTSIAKGKQAATGPIWREPTTHTNGNASGSLTANAASGRYVPSNEPSMSSSDWKRDERMTKVQRMDIDDDLTSVSSSDVHSTSRMSTISFATVDSDPGPSLFGLNRMTSTSSLRTSFDDFSPSRRSSSSSFDDFSPSVQSSNSFSLEGQLAHDFRTQASMDPHTPLTGSVSPPPMQMLSLSPSLSPSISPTPPPISPSPQWMQVPPRAETLSSRRGQAPPYINVPAKHPRSASYSPYDREGRPPRSGHVNKTDINPIFKVVSYKWDDMGGFKPDDISGKSIQPSLPTPISAETDESFSLPPFSHLDAVAREGGYGLPPLSPMSFTSPSEDALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ60</accession>
    <name>A0A8H5LZ60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_000293</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ60"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5374751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="177" mass="19092" checksum="B091F383F8C0707D" modified="2022-01-19" version="1">MIDSLYAEPSAILYIRTHFNLQDVVIVSPDAGGAKRATSIADRLGVDFALFHKERKKANQVSRMVLVGHVKDKTAILVDDMADTCGTLTLAARHLAEAGVAKSYAIVTHGILSGNALEAIEASALEKLIVTNTLPQEANKAKCGKIQVIDIGVVLGEVIRRSHYGESVSKLFHEVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZB2</accession>
    <name>A0A8H5LZB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZB2"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="717" mass="79263" checksum="9E805B3230CBFADB" modified="2022-01-19" version="1">MSSRPSQNFAAALGALHTRRNTPLPPALLGVPSPQYDPATSPFKDIPIGPEPATILLADKSVNIYVLFSTVLARGGAAALTNNNAWNIILPQLGLPEHHSAPDGSLVSVSQLVQHYYSLIFLPFEELYRRNVRDKSQTMRQTTASAPPTMARPPFAGSIEVPEGDQESMKRKLEFEESGGKRARQRTTGDAFDAGFPAVTDPAPVGSTNSVPSSSAAMAAQPRPRHEPSRRKIEYVPLAREVDSYGGRDFRILDKEPMRQWRDLADWGVLDIDALTMSIRSRISTELSYSLTAFALLSTMKGPTPDTGFRIMDCPELLDEVLDLLEDTAFPDQEDTVFDEDLPVVTHRDLVNHIIDLETDPFAALHPLPQLPKDSNPAPRQRPGSVIITVLNILRNLCIFPDNAEYVAKYHSRVLSVLLRLCGATRKGDTILTPSPVILLNDLVVIRKDTLHVLFCTGPHLQFPDPASPPKTPFRVAHRIFNLVASFLVDPNEAVSPFATVQLVGAPVGTYSLKPPSLPDMALEVFTRIGHSDGNRHVFSKAVSSTSLYTLFVSLVHRLPVIDADFQLLSREPWLCFMEKVVMALYTLAFLSPPDLKEKLKSDRTLGAKNVILRMVQKLSVLNSPEFRSYYIVTVRRAIETMKVLDDAKDSFDTSATAVTTISFGMGYGEVGENDVEKGTGLLGGYKDSTWDMLMLRELNIDDTLFAELDSLTRVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AUV4</accession>
    <name>A0A8H5AUV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017162</name>
        <name evidence="2" type="ORF">D9758_019065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000569">
        <property type="protein sequence ID" value="KAF5311253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000345">
        <property type="protein sequence ID" value="KAF5329131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AUV4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5311253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5329131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="12044" checksum="8EF77F61A2B14348" modified="2022-01-19" version="1">MVLASLRSSLSNGYSGNTAPNDSSNVKPKPTYSKPNSNITALAGTATPTSTSTKSTTKAPASTKTHTHTSTPISHQPSTLSSFSLLRRGVFSSWNSPITFVPNPNQLRRVIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AV44</accession>
    <name>A0A8H5AV44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_018949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000559">
        <property type="protein sequence ID" value="KAF5311388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AV44"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5311388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49889" checksum="92EACD18A5C4B72A" modified="2022-01-19" version="1">MGTMYHSDVLHMNILGDHTVVVNSAKAAEELLERRSGIYSSSLQCTWLMNRVMPYTSWWRLHRRTFHQYFRSDAIAAYHPYIRQATSRLLRSLTCIQSTTMVTQYDDLQAIVRQHAASIILYTTYGITEQEDMDAFIELVNNAAESLVTFSHGIFLVDYFPWLRYVPAWFPGAHFKRKATHWSHFTSELANRPWNQLKASIIPLTWGMSKTDSDTKMEESVSLILISVLVLSHHPEIQAKAQEELDRVLGSTANATQLPDFSDRGSLPYVEAIFKELMRMYPSVPFASPMMSYEGYFIPKGTTVVGNAWAILHDENLYPDPLTFNPDRFLKTESQRGAPSAKHPLNPDPELYAFGFGRRICPGRHLALDTSWLVLACLLATCSITRISSDNTEPKSEAIDPIADFINGLISSQTIQVFHYPRSAGASELMKCGYEVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6T3</accession>
    <name>A0A8H5B6T3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000465">
        <property type="protein sequence ID" value="KAF5317869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6T3"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="4">
        <location>
            <begin position="364"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5317869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="797" mass="90167" checksum="F142EC8120E5A37C" modified="2022-01-19" version="1">MCLPAGYGLWDLTLVFTVVDLLYGLLSTPAKTGGHCNPPRFLSGISRLLATLILFFAQLGWPHNALRFHFTDRVLNFLQSEDFGETEGINCVRSFGTSFRLLFWMIIDVLSGYGLRDLTLVFAAMIYGTVSFADPHDKKSWIFCTICYLHRPRQEVTAIYPGFSREFQDSYLIRCPTWLATQLLFRFTDRVLDFLPSEDSGEIEVVNSVYIFCYGLLDWTVVFTGMVYGTVSFADPHDEKSWIFHTVPTSTKNGVYYKPTRFLLAISRLLVTFVLFAAQLSWPYNSLAFILQISFWTFCNLKTGEIEGVNSVYIFSLLTPMTKSRGSSVRSATYTGQETILQVCLGNFKTFGDFVLFTANRAILGEIRLVVIQVGFNPIYDTDMRDTVRFIETNTIKNYMDKLRIPLPDGTAVEAFAIPYPLGVLKEGQIYYKPSNFIKNTATGSRIEVLEGEVLLPHPFTFRYPEVDIPALKRWVDVVIVPTVPVTDIPSITRNMDGDTVFLIWNQDVERVLQFTSRLADLPIEERQRAFQQTYLAGMAHVDVGLYSAFHDAAVWVHGYDSQAATRLAYNPKTGLRLREEVYCQGHAEGKLIIDLLAKAGEDLGDRYLHEFDVNNGLLPEHIANKTTRPDQDLKKPWKDVQDLVQNYSSDNLPEAKRDVIRAALKAELDLVTEHVQKSYDEFRRGAASSSSSNNVYDQPTKKRSGKAPRRDCMSFAKQEYAKHISGISLLSEKVERMKASYAYHKSEKFGNCVGFKQLCAIKADASAQGSAPSTPMFDVTRSMTSGCRRLYQHSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BAZ6</accession>
    <name>A0A8H5BAZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_018929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000418">
        <property type="protein sequence ID" value="KAF5320045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BAZ6"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034592171" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="215"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5320045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="357" mass="38556" checksum="0BE712488C383EBD" modified="2022-01-19" version="1">MFSSTLRSTLIALCFSAVLVSAASELTLKVTGPEAVTNVDNFKVTTLLTNSGDETLHLLNDPTSSLISSDANSFRITNSKGASPAFNGAVFKFSPAVAANMNTPDVITVIPPGQSIKVEHDLSSAYNFTSSGEDVYDIEASNKFFVVDPATLDVTQIHAKQESSHQAKLSGTLSIARRTTKLAKRAGFNGCSDDQQSNITSAIPAALTYASDARDYLGNHTYSTPRYTQWFGTYNTARHSTILTHFTNMAGHGYNDYTYDCTCPGNPPPGTFAYVYAEDISTMYLCDGFWQAANTGEDSRAGTLVHESSHYAQLAGTVDEAYGHTNCENLARYFPDLAAANADSHEYFVENVNPTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BLK9</accession>
    <name>A0A8H5BLK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000384">
        <property type="protein sequence ID" value="KAF5325577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BLK9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5325577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="35892" checksum="1098AF10AE0FD033" modified="2022-01-19" version="1">MATSSSLRSAAYRLMTRSSTTDVREIPSSPPIPPPSTTTTNGKPPPPSRQNTRKTTLPFGWSSTAAPSPARASDVTANSSHSGSSENIKDHSRPSVDELLATRTLEKEGLEKKLADAEESLRRMESGLKEATQAKVLSETGKKEADDAKDLVEAALTKMEKESEEAKQALIESEGKLKKLDEERIEREQAEREKDEEIMRMREEGKRKDENIEKIQAEKESLESEVRTLRDVLREIERQFEDERARREKEEEGRRDDKESYEEELGKLREEILNVQRQMEEERTSRAKAEDNLKQKENEMVLARKPYNSSVCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BSE3</accession>
    <name>A0A8H5BSE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000362">
        <property type="protein sequence ID" value="KAF5328473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BSE3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034103811" evidence="2">
        <location>
            <begin position="30"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5328473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="59881" checksum="AF8955DD9B9CE397" modified="2022-01-19" version="1">MVFLTSRFAVLAVSLSLALLSVSPAPVDAVAIEPRRQHTTAEQTTIPLPPKAKLAKASTSKASSKKVSAKLPGASVHLSKGEKKKGKSRAKKEGDVEERGLWVGLGGVDHLLQSYFHVRRDHHAEVIVNGDRNHLRLNHYYDDHGHHKFVVNGDRNHIRLEHRDEATMSDVEPRHEDKVVLNGDREHVTVDCDDPHLKVIVNGRHDHIRCRRSPEQEGTADSHELHARSQRYYRHPRDVQERTTAPEGFVGVFSDSKQIGALCMSSTSEEFDVCEHPSDGTLLELMRDHSMPQTDPSSVVVRMVVHPGNDESSPRCVSFSKDSSSSPQSLKASPCLPGEIAQTQNSSQFFDFKPNDGTIDPLSYQTSDDDDLAQPQSVDDTPVGSEMLASRSPTTEPVTLKWMPAAANMTMQDVEPSSNSTVTETVTTTMTATSTSTSASSPSTTALKVEVYAEDSSSDVVTTTSSTDPSATMTSSPTDSSSSSIESADSTTPTPSATESLDADAVASSIASSSSAPSTTDSSSSTDSAASASTASDASATLARRSTAPYAWKFMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYP5</accession>
    <name>A0A8H5BYP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYP5"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="825"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="772"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5332012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="969" mass="100431" checksum="E094B5EAB2590CD6" modified="2022-01-19" version="1">MFGNNITSSWTNPQQNQQQQQQPSAFGQPSAFGSTGFGGGTTSAFGQPQQQQQQPQANPMFGNLGGTGTNPGSGGFGAFANNNSASTSVFGAPKPATGFGAFGGGGTGTFGGGGGGGGGTGAFGGTSSTTSAFGQPSSSTNTFGGGNNIFGQNKGTSVFGATATNTPATNPVTTGSSNPPYAVHNEKDPSSTNMTLQYQSISCMPAYQGTSFEELRYQDYQQGRKTATTGGAFGQASAFGSAQPTSAFGQPQPQPQPQPQQQQQQQTNSVFGAKPSGFGAFGNTNTNTTGNSMFGGGGAFGQTQQPQQPQQQQQQQQTNAFGAFGQPQNQQQQQQQGTGLFGNANTAANPTGSAFGSFGNTGTTGTSAFGQTQQQPQQQQTSIFGQPQQQPSTGGFGAFGNNSANKTSIFGQPAQPTQPSNTGFGNTGSIFGNTQNQQPQPQQPSGFGNTASTGTGLFGNNNPQQGNQPATGNSLFGNNQNQTSGTGTGLFGGSSLFGNNQQQQQQQQQQPTQNAFGSSLFNKPAAPPGTTGTGLFGSTFGQQPANNTQQQGGLFGGLGQSTNQQPSTGLFGNANKPPAMGTTPSTGGSGLFGSLGASTNTFNASAAAPGVQGMLTASITQPISADLPIFSMLPPGPRSVDLEQSTKKKPVSFYVDIPTRSPIPRIGAELGYTPSASRLRGFGKSTSFSMSGNSLLSSTSTALTVSRSQTPKDMFTNGTPSSSLGSGQRKSVKKLILDKKVEPIELFQKSGSASPLRGKITFSPALSIANRERENKEAEAAAAAAASSSPTRPAKSPTPTPRPQRTPNRFTAENGADGEDADRDEGDYWVKPSLETLKTLGYEQLAAFDGLVVGRVGYGEIHFLEPVDLTGLPKLGALLGEVIKFDDKECSVYPDNEDDKPPPGSGLNVRARISLKRCWATGKAHREPIKDEKNPLAIKHVKRLRNMKDTHFENFDFSDGTWTFSVDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZU2</accession>
    <name>A0A8H5BZU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000309">
        <property type="protein sequence ID" value="KAF5332373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZU2"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5332373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31056" checksum="06A525133430A02A" modified="2022-01-19" version="1">MSSLTSSSEKPRKTAIVTGAANGIGRSIALRLARDGFNVAMNDLASQRDRLVSLSEEIRALGLGSESSIHVGDVSVEEDVKGMVEEVERRFGGVDVMIANAGISPMGSLFDTTVPQWDHTFNVNVRGTFLCYKYAAAQMIKQGRGGRIVGASSLSGKTGTPYNFLIAYTGTKFAIRGITQAAAGELGKHKITVNAYAPGLVDTEQCECFLTSYRDRTLDSCLPTAQVIAEKFEKEGNMKPGDFYKSVNANVPVGYTGVPDDIAGLVSYLVSDQAHFITGQTISINGGVFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3W6</accession>
    <name>A0A8H5C3W6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_015550</name>
        <name evidence="11" type="ORF">D9758_018590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000454">
        <property type="protein sequence ID" value="KAF5318281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000263">
        <property type="protein sequence ID" value="KAF5334284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3W6"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5318281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5334284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="12495" checksum="AE70AD9906DA7DBD" modified="2022-01-19" version="1">MGAYYDEIEIEDMAWDAEKKVYHYPCPCGDRFEISKQQLRDYEDIATCPSCSLIIRVVYDPLDFEDEDEDEDGDEEEEEEEETQSDSESEKFEDAMEKLTIAEVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4X4</accession>
    <name>A0A8H5C4X4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000255">
        <property type="protein sequence ID" value="KAF5334591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4X4"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="11517" checksum="1638A321936A2F2B" modified="2022-01-19" version="1">MECTWAGYKIREMRMTRYHHCSSGTSSAKYNAPTLVWNDTLATYAETYINKCIWEHSNLNPYGENLPTGYGKSYNIAKGIQDWANENRYNSSAEQANSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5P9</accession>
    <name>A0A8H5C5P9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5P9"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16947" checksum="C2EAB0BEAF532C3B" modified="2022-01-19" version="1">MIMGISLTCIRNHKHVVSGGKDIPSIVTDILKNGASLAIISRNSCKAIYDRALYYFKAVNPKTGEKESIIKMVRYDEVVNETKTKHFKRIRSWSKFDYADMILFDDELRNDVVKKELGIGFQQCSSQEGLTWEIYLKGIEHWRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7I6</accession>
    <name>A0A8H5C7I6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000242">
        <property type="protein sequence ID" value="KAF5335437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7I6"/>
    <dbReference type="OrthoDB" id="3004152at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="815" mass="91170" checksum="3F958BCC06FEF416" modified="2022-01-19" version="1">MYRSTWIISISTCFTLMGKKKLSSKKKPGRAPWHKDDPEKLEWLRGYISDWKESQKGKDEAKSKFYNALTLEFIEKFNDPLHDDDDPENCDDKNRGNANGSTTGAAIPAVGNASGHNHTLLPDPNVNQATVTSPSQPTTSSDNSQGLNPGPDDAQITPTPSQNVPADNPSVPDVPADKTTGTDQQPSLDDPAVPSAEKPSGRDSASQGSTGTPQGITSREFTWRINEKLNGLSDEAFERKHKIIMKRRKQISEWYRENNRSVQRGTGGLIEKVFAKPKPTRKPTKMPAPQMFQDLYYDSYVKKEAEKEIELEEKEYDDWEKAGSVGDKKKPAPVAIRLRVATRILQSQPQEFQDEINKAVEGLYNKELEEWNEKPEVVEPKTKTPEDFQKALQSWGPEVAKFGKAVSEDTGMVLDTSWNNVDWTTMAYEATKQSLIRFGRKVYNHESRAARAVGNIPVVPVPSFNDVEPIPASSTATPEPTSSTQLKRSSWKSMGNSTEKNKDASTIEKNPKISRPRPQPPPLPEEPSSLGDTRDSDPKPAQTVSSGSQPPSPSPASANAQFPAPSMSALPEEVEGTGSVAMEGIRADGDIQADVHMDDPEPKAATEWGNKFDCCDRAEYPWKDTLDSLLEVYIEYEGYFHYTEVNGAIESKKEPSLLKRWVRKGQPPFALFNEELSVTAPKMLDVFRGWWEDVQPVRESDQEDWAPFDCVSGSGGVWKFICVLIWLLHYFLGESPGEDLTDQQMTYIASWMVLCTEVEETLAKVMRWGITAPRKRKSATSPEETDQPRTTRRMVALQRVNDAAKPKSTKRRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAK7</accession>
    <name>A0A8H5CAK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAK7"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="337" mass="36858" checksum="016A7043257AA03E" modified="2022-01-19" version="1">MSSPLKIAAVQAEPVWWDLQGGVAKVISLIKEAAANGADLIGFPESFIPGYPGTIWTGGFDPDFLVQFQKNCLDVQSEEFNKIRRAARDAKIWVVLGFTEVSGYSMYGALVFINDQGQVVLHRRKIKPTGQERTIWGDGPADSLQSVVDGPKGFKIGGLNCWENLQPLLRFHHYSLGCQVHVAAWPYLCSYNDPKIYPQFVGEMQTIATRLAALEGQMYAICATQIITPQNYELCRVQDTLWSPPSGGGFAAIYGPDGAKLTPDIDPGKECILYADVDHDAIRMAKLAADPIGHYSRPDLLSLNVGSASSPKNPATLVRSAIVTDYTLTSRIPPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBR2</accession>
    <name>A0A8H5CBR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBR2"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="222"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="37742" checksum="4ED1A34F3F1E44B6" modified="2022-01-19" version="1">MLVESIAGSSSSSRSSKSSRSSHTTERSDFISHDLRPLPPRSLDDVSEQVAQEIAWKAVSSADILDDVKINVIMTFCKRDDNGFLQQVAESIEKRCLQQYLFAIGTSGKPIDSNSNFVILCSSSEEMVQRAVLLTTAKFIGRVDSARPDRKWYITGIKNVGFTSYDEQALWDVVRKSARTPIDPLDPPPGSRTIEQILSDRRAKLQRITPEQSYKELQEPEVGAPTFLVDIRNAAQRESEGSITGSLVIDRNDLEWKFDPRSKTSKLNIVDRYDLRIIVFCQDGRASSLAAYSLQELGMLNATDMIGGYKAWRDAGLPVDIPLRDHRLLLLGDAESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCK0</accession>
    <name>A0A8H5CCK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCK0"/>
    <dbReference type="OrthoDB" id="3262423at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5339259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="64068" checksum="4665AFCCF9277D80" modified="2022-01-19" version="1">MSTTTTLMSVPSPYPFLHGSTASLLPGQSTTSLPAYTRRASPSPLRTPRPKTEHVVELSNNSGMGGASSKKSKPWAVLKVYSNARSSKSLPAFVEGERLTGSVTLDLGSGSWMSGNSGHGDAITSVKVIIRGEFASGNNSMEGNKTFFEMTTEVWTKDAHNTKLSGVQHWPFSISLPKNVFPSGDDISELSYPLPHTFLERHTGASIRYDLMVHIVRNKLRPNSNLQQTFVYIPAIRPDPPSLLRQLAYQEHSPLAGPTVDPEGWLTLAPVEAHGTIFSSRSVQITCTLSIAKPLSYTRNSFIPLSLLLESSDSQALDLLTANPGSSIHVRLRRQTRLLKPETVIDATTKQWMWAYHGEKMGGIHYFGDTTWWPSTLDNEDAAEHRKRIRLDGEISLAKDLKPSTFIPYFAIEYSVVLLPFTATGFVPSPSPSPSPSPTPSLTSPTDYLPTLPPKLNKKSSRPSTSPAPSSSLSGRSASYSASTSNHAHSQSLALPTRSASFTPRPSTSPSISSSSSPNTHLSPNYATNSSVAKPLLSQTVSIATVFAKGPRPLSGRPVSMAQYPGSRGDGRHLGHGDVRDDSLPPEYDDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEY1</accession>
    <name>A0A8H5CEY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEY1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="711" mass="81262" checksum="7A1A89D49E21F30F" modified="2022-01-19" version="1">MHVILLRTRANFTAVKAIISSILSDDPNTFIIPEQEDSVREILVEIASYVRHLQKELVRARRQTGLIQHQSSPMVEGDSPSTENDDSDYSEGDLLSQEMAKMRLSRIENRHFGRSSNAFLVASALEFLKQGPAFDKRSEYWVLSPYERTRIEEEPMLQFPDDDHLQRLLEAYFAFHHPYQPLLHRASFERSVAEGLQLRDHQFGALLLAVCSVASKYSEDPRNLPKESSAVLALGWRWFQQLKLTRLIFAEPVSLYELQTYCLQIHFLQTSYQSEAAWVLAGLCIRFAHERGLHRRRDPSEKPTLERELWKRAFWFLVCVDTILGASLGRPSATSKDDYDLEPLIEFDDSAWDSPFIDVSALAPSKTSISAYCNCLVQLIEILSFTQRTLYSIRKSELVETTRISDTQWTENTARQIESALNNWEDTLSSHLKWDPHHPNNIHFVQSATLHAVYYWVQMHGHRSFIPVLKRGGPVSIKFSSVAICMNAGRSCVNIAHVFFKRHRYVTLPLPVECTTVKDVEVVLTVIYPCELQLQLNRQKEMLNVYKCLEILREWEKSDIIQAIVSSGGLQPPYQEDPQETLKRSRETEPEAFFDIDASGQNPNPQLSLSALDWTTAMNDIGDEIGSADQGPSHVYAQGNIPDVLRPVHGLQSVSYDRPNPMQPNPSFGSLIPYSPLPASVDSTRNEVYQEDWDAFMANVDRFLGYGNFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGF3</accession>
    <name>A0A8H5CGF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGF3"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="467" mass="52717" checksum="4E1E797E62B97FE3" modified="2022-01-19" version="1">MLSKSSFPVEIVEKIVEEHIIQNFTLNKKENRGDNSKTERKDKLRQNKALLSLALGCKSFTAPALRAIWHTLDSLEPLLKLLTNSKVDDRTYDLTSKPSEASLERFDFYARMVKKIIVQGSTWSYPSKNSVLVRLSVFQNLSLARPTPLPSLTSSECSASSFARAMMFFISPKLQEATFRFDSQAQFRIEGASMWRYLDVVKEKCPAFQRLDIDINGQGGGGVLRVPSVFQFDDLRHLSLVGFTSVETISAENGHLVSEFLSGRRMARLESLKLDIPKLAIKSRTEESESASKSQSQSQTESASNQDPDALPKSLKALSLSLSFDDYASDIAVPRLIQLYRASPVQFFQLTGHQVDIDKNDIFQTIASSPSWSGLATIIVHSDFDFDIGMKLGVFSVSEYISPLYELRQLRVVRFLNLFNRYNITNDDIWTMCEAWPELEEPHFGFTGGCHWRPAGESYCFFVDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL65</accession>
    <name>A0A8H5CL65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL65"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="15270" checksum="4B625AFE7F97F1AD" modified="2022-01-19" version="1">MTKLDFTVWEGNWDNFTHALKVQFGVANKQQLAQNKLEALRQGDKTVLEFSQIFKMWVEKTGFSDMDLQYKFWKCLHKDLLFPLANVELGQKEAPKNLDKLIDQGLHMEQTLAELLGRPVTGPIPSLSKSSSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ10</accession>
    <name>A0A8H5CQ10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_011989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000111">
        <property type="protein sequence ID" value="KAF5345558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ10"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="144"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5345558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46215" checksum="94C62E7CC45CAF10" modified="2022-01-19" version="1">MAKGFLANLKGVDAFGKTTEDVKVKTRTGAFLTILSAAIILAFTAMEFIDYRRVYIDTSLVVDKSRGEKLTVNLNVTFPRVPCYLVSLDVMDISGETQRDLSHNVLKTRLTPAGAPVVGSRVSELRNEVDKMNDAKVDGYCGSCYGGIEPAGGCCNTCEEVRQAYVNRGWSFSNPDAIEQCKEEGWADKLRDQANEGCNVAGRIRVNKVIGNIHLSPGRSFQSSGRNFYELVPYLRDDGNKHDFSHTIHSLAFEGDDEYDIYKAQASREMKKRLGIGANPLDNFMARTSKPAYMFQYFLKVVSTRFRTLEGKTINTHQYSVTQFERDLTEGASGDTPQGVHVQHGVTGVPGAFFNFEISPILVVHSDTRQSFAHFLTSTCAIVGGVLTVASLLDSALFATSRALKKGGGSAQGNGYGSSKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQN8</accession>
    <name>A0A8H5CQN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQN8"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15525" checksum="1DD7274D3856CBA2" modified="2022-01-19" version="1">MSAITRNKQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFARRNQFTLLPVKNPFPVRNVDGSENTMGWVQEYTIQNLRIYSRDSKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRV1</accession>
    <name>A0A8H5CRV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRV1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="18877" checksum="B45922EF401312EF" modified="2022-01-19" version="1">MAVVWFQRTEDAAMAKMKYDSNAVDGHKTPSSSSGSASAEPTPPPSHIDRIQGRGNINAYAVASSSSSPKPLSISRQEAAVAAMISSSSSSSSFTPLNVTPNPNSTQTTQTTRRRHKKGPKRLKKQTVQFVKVHPNSSTTTQSGGGSVKAVAKSKQDLDQEMDDYWARGNRLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS20</accession>
    <name>A0A8H5CS20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS20"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="231" mass="26150" checksum="58DADF8D921AD622" modified="2022-01-19" version="1">MSPIPSTSIRRRRFLLYTVLALLSVFLFFHTTGISWELPSILKDSNLPSLSRANIVSLVKFKQDSSQGSQKSKFDAKVDEIYGLIHLVTGEDEENQHVLVNMREFDPTEPVGMDVYAPGEVVHWQEEAERLDEVYPMVVFSKTFCPYSKKAKKLLEKYELVPQPMVVEVDLRDDATQIKALLTRLTSRSTFPNIIVLGESIGGSDDLNRLHENGSLKKLFEKAGFEVEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTJ0</accession>
    <name>A0A8H5CTJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTJ0"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5347687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="137" mass="14924" checksum="42ECE4646AE76C2E" modified="2022-01-19" version="1">MSTNRGTYRTNAPVTKSDMAPKTEPPIRMPFEVAKHTKIIFVIFSQAAAVQPGSVKDVRPIVNVPSVMEARSTYMMKVKGGGHGMAPGFSSTTSIQISMIRLSKIKYNPNTQLIEIGSGCLWDQVYSTLALTGYEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUI3</accession>
    <name>A0A8H5CUI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000087">
        <property type="protein sequence ID" value="KAF5348212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUI3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="483" mass="54433" checksum="6DEBEDC62FE61983" modified="2022-01-19" version="1">MDILTYSFLSYIYRRSLGIEPVLLFQSLPSEPTTENPNPVRTPSPTPSHEPNPDSETPLEPQIPLNRSPTDSTPSAVQEPISVNPSQPIDFHSLHAALEMSEDPATAAAGGTQTPHDAAPFDDDAQSSALPNMTTKERGVKPEKFTGDRNQTKDWMAEFNNYLHLNDQVYPTENEKISFFLMLFSGDEAKRWAHNMMVKVFEEEDDFSDSDEEYTSTDEDSSASKPKTKSWTLREVKREFLRDFKPSARETQAQTKIEHIRMEGTLADIDKYNSQFKRYADDTGYNDKALMKYYRKGLPRGLVDRISYLSTQPKNLVALQKAAVKQHMIWLERQEEKTSWNKPRREEGQPGRRSQGTGSSGTRSMEVNAFQDNAPGASSIAKYPLKLTPQERDKMRKEGRCFRCRGQGHIGNDCPTFPSTPLTTPNNTTWRPSIKKTAAVTETSDPKVNTTTDNISELTARIGALSGEAKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVD6</accession>
    <name>A0A8H5CVD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="658"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="910"/>
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        </location>
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        <location>
            <begin position="1021"/>
            <end position="1151"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1226"/>
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        </location>
    </feature>
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        <location>
            <begin position="1293"/>
            <end position="1357"/>
        </location>
    </feature>
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        <location>
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            <end position="1726"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="410"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
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        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="1699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2376" mass="259955" checksum="9F666669BEB2C4CC" modified="2022-01-19" version="1">MSSTKSRPSGWPDSSHSPSSSSSTSASLSSSFSSGSATSEMHESLSDFTQSDHSASPPLPTPIPRPGRVHDLALAAPRPRSSSLAAAMGQSYSKPSPPPSAPANLAQKGIALTAGVANTGLKLKRAFANRRKKSEDATKLFAGRAHAEEKEWTTVVAPPPQATSSTSVAAPVEVNAPPSRNPKGGKLTLQLAAHALRGNKEQQKDPLPSPLPPPPPPKPASMQPSKAPGSPPSSSIHSTTLAKPDIRGSIIPISPGISSAVNFMISNEGQERVPQVRAQEVAEPSDDEEKDIWRKSDSTMSHHTIRPGAGASNRSSRPVSMAESMSSNHTVVPSNKRLSQLVMDSELDTPEEDDSSFKSASEELPPIPAPSDTVKNRRSMSLNLGSITPKFNLPNPPASSAGTLVEGKSISKSQPENHSILAPSTSANETPTLTRAAASGIMSQSQNGTPSAGVNIRGRLAALTSGTTRPERNRTPPSAYSRNTPSPQPQPQLQHSRAAAISISGFGPAAGLAKRAVEKMGRAWGGFSSSSSGSVYSSSSSSTGHSSDHALARTNSNTSSSAMASGKGKNRRTPEAPSGVWSLASSGGASSESDVFMPAPSGPSLGHCIRRPKRVGMSGEVASGVVFGRELRTVVRETAVDAGVNEHDAQGKPHDGEGDIDPAILKALEARALPALIVRCAQHILLWGVHEEGLFRVSGRPSHVTKLRNEFDSGADYDMRSCSPGDLDPHAVSSVFKAFLRELPEPILTLSLIPYFEAALAQEKETISREPPTQPRAARGPTLPSNPKSGVQGLRKPPSLSTLAMPNFSGMRPPSRSLCNAFKSLIAQLPQENKDLIRTVTDLIKATAKESRQTKMPLSNLLLVFCPSLNMNPPLLRVLCEAEDIWEGPPIESPVLDIKRESVVLDISPSAMDSSVDDHDKEGEQADKPADIQEQDLETSSPPSIASGPPSQEHPSTADKKGPRARPLGPRRAHVPPISVENDALSGTSDSSVESKESSSVIRSSFESAIAQDDVISYTSTSESLTSPSSGGFMASSPPFTSSVESLDTPLSSSASPSLQDLHAVSQQCKAVEGPGPAVEIADEEDILTPRRTITNGSVQFPTTGSVPSTPMSPRTFIPSLSLPGLSSQKSPISPTNSAPASPRNRRSKKPSLHLLFSKRSASQLSTSSGGIPYISSPYLQAPRAASDSSVSTPSSTMTAPQSSTFTLPPVLDTPIESSPLHFGLGFDPKSPPISPPHTDTNLPHKDSQPVISTPPEPTPAPGETPIASQYSSSSYTMASDAVKKVQEKLFRGGPTSNIEGLPSQPDRSEPALTISIPKPPATPAPPPKTSKQPDSPSNGVEADATRANGDQRPYRERLMSTLGNAYKGVERYRLEQDDNKERHWKRWGPYLSDRQWATVREDYSGNGDAWSHFPHEHARSRAYRWGEDGIAGISDNHQRLCFALSLWNGEDPILKERLFGVTGHQGNHGEDVKELYYYLDSTPTHSYMKFLYKYPQRRYPYEQLVSENQNRSRDVAEFEILDTDVFDEDRYWDVFVEYAKDEDDPDNVYVRITAYNRGPDAATLHVIPQLWFPNTWSWHTEKPQMPSLSAHSRGGVNCVSVKHPSLGKTHLYCLPSPPPVGPDGNFEVDCENDTVEPDLLFTENNTNFSRLYGGTNETEYVKDAFHDHIIPSHRPPTDESEEQFFSQRTRPRTSSTFGGSVVSDEPEEGPCTPFPRGPSFVNPDKQGTKSAAHYIFRNVPGQGGCAVVRMKLTPLTPKRDASLDDEGVFDDAIEARRQEADEFYNSLVFGPMSDDLRQIMRQALGGMLWTKQFYQFIQKDWLAGDPAQPPPPPERQHVRNKEWRHMHVADILSMPDKWEYPFFAAWDTAFHCIPLAVVDPAFAKKQLDLLTREWYMKPDGQLPAYEWNFSDVNPPVHAWATFRIFKTERKLYGKEDLEFLERVFQKLLLNFTWWVNRKDHDGSGVFEGGFLGLDNIGVFNRSEPLPTGGSLRQADGTAWMAFYCLNMLSIALELAKHNHVYEDIASKFFEHFLFIADAMTYKEGDNELSLWNEEDGMYFDAIQFAPGSSMQLPVRSLVGLIPLYATLVLEPNVLKKFPGFKKRMEWFIDNRPEVSNRNMANMKAGGKDQRRLLALASKERLVKILEKMLDEDEFLSEYGIRSLSKKHKEQPWGIDVHGQRYEVNYWPGDSHSGMFGGNSNWRGPIWLAVNFLLIESLQRFHQYYGDDLQVECPTGSGDYMNLVSVAEEIQHRIIHIFGRDVQGRRATNGGNPKLDHDPHFRDYVWFYEFFHADNGRGLGASHQTGWSGLVAYHILQSGVTCRLPKTPRTPRSLANHYFDDNIETRSEFGDETRSAFSTMSGYDLNTLGDISPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWP4</accession>
    <name>A0A8H5CWP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWP4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="293"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="481" mass="54602" checksum="DF0CB8EDD7929AD9" modified="2022-01-19" version="1">MRGSRIPRTTRSRTASQNPSRTSSPHIVCLRRPHAHFPRNQQDCYFSHENRWEFCATHPCPNRLSVNNRPLSIEEQTAGIEPVLLFQSLPLEPTTENPNPVRTPSPTPSHEPNPDNKTSPEPQVPLNRSPTDSTPSAVQEPISVNPSRPIDFHSLHAALEMSKNPASATAAAGGTEVPHNAAPFDDDAQSSALPNMTTKERGVKPEKFTGDRNQTKDWIAEFNNYLQLNDQVYPTKDKKISFFLTLFSGEEAKRWAHNMMVKVFEEEDDFSDSDEEYTSTDEDSSASKPKTKEKSWTLREVKREFLRDFKPSAQETEAQTKIEHIRMEGTLADIDKYNSQFKRYADDTGYNDKALMKYYRKGLPRGLVDQISYLSTQPKSLAALQKAAVKQHMIWLERQEEKTSWSKPRREEGQPGRWSQGTGSGRTRSMEVNTFQDNAPGASSITKYPPKLTPQERDDASDAGDRDTWEMIALHSLVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0J3</accession>
    <name>A0A8H5D0J3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0J3"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="8">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5351285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15423" checksum="5F19FD4065F79A41" modified="2022-01-19" version="1">MSQPSNFKRFVEVGRVVLLRSGPSAGKIAVIAEIIDHNRAIIDGPLTDVPRQAFPYKHLVLTPIHLTKLPRGAGTGVIRKQLEAEAVLTKWSNSSWAKKRAAIEARRSLNDFGRFSIMLEKRRRRDVVRKSVKKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0Y9</accession>
    <name>A0A8H5D0Y9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0Y9"/>
    <dbReference type="OrthoDB" id="2836053at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="341" mass="38275" checksum="BD4DFCA860C9D0AE" modified="2022-01-19" version="1">MSNVPELPPELISAILDIFWSSDDLLPKDRITFMTSSLLVSSTWATQFIHITTKDVYIPTPSYVPQLLRVLRGDSSSYNGCGFALHNALTRSITFRYDGDPEKMMLTRQHPHPMSLAVLCVFHVLFIPTSFTERLPNLRRISIELNNCTIDDFFSRNKFYAFPRQVTHFDLRFSYSPFVSSADLFEMMGSEKPIGLVPGSMPNIRHLSLHGATEVVLNEFIWACPNLEAVVTDVVGYDGPHYEEEQVGADDVEDDEGGEEEAEAEDDAEHEEGESQSTGQARLAGQPTRVDEKEDVEEVDSGYASAEEDETSHCHEEPSTSSTLKVYLRHCAPHLPDIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1Y3</accession>
    <name>A0A8H5D1Y3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1Y3"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="452" mass="50755" checksum="24D7175B5D54BC22" modified="2022-01-19" version="1">MSDNDSETVVIKGVWTFSRPFSRFGVIPIGGRSTAIKLRDGDVWVLASTPLDSKTKSTLETLGPVRYIIGADAVHHLFLSEFKRAYPDAKLIAPQGATENVADKSLKFDGVWGRDPPDTMYGFEEEIKHCYFSGFINKDVAFLHVESKTLIEADLLFNLPPKEQYSQSPSSGQVPGFSNFGPSSWLHSKVSSAMNVDSARAMKFDVKTVTSWDFDRIIPCHGHYQREHATVKCLCGVGVRKDLLPQHYKESDRHPTCGTCDESFQEEGHYQEHLLTKHVDSTCSKCALGFNDHDALTKHWLTSSEHPVCSRCERGFIDEESLQEHLDSEHPLCTECQTRFDCPETLDWHWKELEAQARQSLKQCEISLTDDDVMGKHLSLYPNLATIVPFLEPDWEPSSSTLTFSSTECSPVTSSAGESCRGNPPAYHCRACHRPDCVIPTFTHCGHLFCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D282</accession>
    <name>A0A8H5D282_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="6">
        <location>
            <begin position="317"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="822"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="855"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="888"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5352292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1336" mass="145366" checksum="AE5CB0263DB956AE" modified="2022-01-19" version="1">MERCASAQSDVIPGARSDGRAGDTRHAAGGSIDQAAKDGNGHSKADVELSRSISVAAESYHGNYAAAAGSRLPPGTLIVPLTDQASSRSLDVQDTHTIAAATSTLPQHTPGHDQDLPISQSLASISADVTQKDAGRRISDTSEHDLATGNRNSLEAPLLSTPAVINNLVTVSSTSQVQNNEGPASRFKIIGRLTEKMGSQWRNNLLENTGPIPQVQDQTSNQNNQVKNMNDSDNPYGGTSTPPNMQATKTTHPQDNRVHVNGNDQGQTTGEDSGDEKKKEDQHRLLGIPGYQPSYSGNRNYDYTQKYPPDELGKEQGFRDTLDALLVFAALFSAVVTTFIVSTVVALQPDYAQITARLVLEQNQLILAVLTGNATTISSAQHAPASVNLDTADPSAKDLWVNGLFFASLLLSLATSLLSVLVKQWLLAYVSLPSGNAMERAKIRQFRYQGFKDWKVPEIIGALPLILHASLALFMIGLSIYVAQLHGAMYSIVVIITAFSFLMYLGSIFLPAITIHCPYRIPILFIPAHYCLWLFKKLYFWNLCAQWQSFSQKSITETEISYLHPEFNSHGDALLSFTRHHSALADCLQWLQSLESNSSIQQTVAQAVCGILKEQTQCRGALECYAKALDLSSIANVTWNALIHMKNRDWEWPSLCMEWKNATLFPAMEIKYSLHEAADAGYFHVVKVLVMIGENINMQGGYFGTALHAAAYRQNLEIVKYLVENGADVNVQIGKYRTPLLAAAYQQNLEIVKYLVKHGADVNVQGGKYGTALLAAVYPQNLVEQRADVNVQSGEYGTALQNLEIVKCLVEHGADVNVQGGQYGTALLAAVYQQNLGIVRYLVEQGADVNVQSGEYGTALQAAAYQQNLEIVKCLVEHGADVNVQGGQYGTALLAAVYQQNLGIVRYLVEQRADVNVQSREYVTALQAAAYQQNLEIVRCLVEHGADVNVQGGKYGTALYAAFPNLGIVKYLVEHGADVNVQSGEYGTALQAAASQQNLEIVKCLVEHGADINVPGDKYGTALYAAFPNLEIVKYMVEHGADVNMQGGEYGTVLQAAALTETLDIVKYLVEHGADVNVEGGKYGTALQAAPPNLEIFKYLVEHGADINVQGGEYGTTLQAAAFQRNLEIVRYLVEHGADVNVQGGKYGTALQAAAYRDNLEIVKYLVEHRADVNVEGGEYGIALYAAVPNLKIVKYLVEHGADINLQGEKYGTALQAAAYRENLEIVKYLVEHGADINMQGGKYGTALQAAAYRGHMEIFRYLVECGADLHLQGGQYGTALQAAAYRGAFDIVKYLVEHGADVNVQGGEYESPIKAAQYMGYNKIINYLQEKGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3M1</accession>
    <name>A0A8H5D3M1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5352986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="16498" checksum="C22C5A66F0F0B547" modified="2022-01-19" version="1">MSDDEQHNQTFEATSAGASLTFPMQCSALRKNGHVVIKNRPCKIVEMSTSKTGKHGHAKVHLVAIDEDISPSTHNMDVPNVNRTEYQLVNIDDGFLNLMTQDGVPKDDVKVPEGEIGTQIEAAFNEGGDVLVTIVSAMGEEQAISFKTTSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D425</accession>
    <name>A0A8H5D425_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D425"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1129" mass="118386" checksum="B2345F09D90DA7E2" modified="2022-01-19" version="1">MMTGPLPLPISTRNRHHNHFHRRFQFSRSKAAHFYFTTSLHVIDEECLSDENQGLSASLSLTPTKPKSAEKSKPKTMNRPHTAAGHPPIGRSLSTTSTPTLSAATVRRPSQPSPLAGSAFASTYAMFSGGASITPAVGRAGKPIAVGVGESKQKPHLHPQPHPNPRYPYSKPHLHQTSSSPDLSTLYSSRLTAASPSPEPVRVPPSSFDEQFVVGSKVSAVVQGQGQENGNDNKSKSKSNHSHSDFSLSSFLVPTPPMQMPTAPSPLLSRSSSRSSARSVSPAPGQGNGHKNSHGIGNGTANWMTVNTYAETPKFTRLGLGSGSPGGGGSEGVVMPISAKQHAKEKGKGKGKGKERKEELRRSKTMTSLNTLGVGNIASGSGSVPTSVYGHGRSQSTRAYTSGLNYASNPNFTATATAIATTNPYASPTSSPAIPVSSSLRPPLMEVRAYSEPVVPVLPGVGLGQKHIHTHTPSVSSVSSFSSINSKSSMSSKFLKKGKNQTQNADYDPNHPSLTSSRSGSISSVVKNVKGMLQRRKSLASVGSSGGWHSRASSVASSSSSVGSGSGLDVGAIPPVPVPVPLPVSAPVPVPEQKPQHPHLHSHPYHSQHHKTLSTISYESSRSVPAILPRLSVSEEVDGELVDKDKDIDGDEYDDEYEEDEGLRDAQMLLDVVLAFHQSGTRSECSVRSKKRSTVTNSTVPTLRPATAPVPVFMRVDVDVANAIANEELSANGVQRTTSSSSNSATTPTTPTPALNHQNTRLLGIGSGNGLGNGFGEMGGNRLSVMSSVSTVPSMYSVESMASPMREGWGWHSVGTGIGVEDGHDRGGFSPTRTIGSASVSSGSGSSAFLLMPITPISHTQLHLPVTVSTPKGVSPSLGLGSGPGQIPEQEYVPGSGVPSPLSRLSPPSSLPRPATAKARLQSVKSEFSVPLPAPGVLASRPGSARGRLYQSQGQTQNDHSDWSSSSPASAPEFPAPIPVPFPALGVLASRPGRSNRSPSPNHGKSDKPELELGVSGLGPMTIPRLGLVEPEPQPSDAENFDQPEGAGANANDDKRREKAMKFFGMEDIDAFEKAMSMGMGNKDFLDADPYSNSGQRLGLGVDPTATVKKRKSSGASMRKFFKNLAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4X4</accession>
    <name>A0A8H5D4X4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4X4"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000044">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="176"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="660"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5353676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1121" mass="117631" checksum="FA76B8AD34689CAB" modified="2022-01-19" version="1">MDPSSHPGSDSPPLRSTILGTFLRGRPRNSSQSHINTDPPRELSPSPPGQPPSPGGAVASTNHRRRTAVPQAGGPVQPSNSNSNPPSLGLTGMLRRRRSAGGMNSNPAATTAAPVPTGSSSHSRPQTTHGQNSAPPPPAAAAAGTHRIRLVPHLESRRSLKFDAITRDLKPGDPALRIGRFTDRSGLGLSAVNALGSNKLAFKSKVVSRAHAEIWAESGGKFFIKDTKSSSGTFLNHMRLSQANSESRPHQIKDGDILQLGVDYQGGTEDIYKSVKIRIELGREWQSSANAFNTNAIKNLKSLSAAVAGKGSKLGLPDCCICLFGVTIRQALFIAPCSHTFHFKCIRPLIESHHPAFSCPLCRTFADLEEDVEVEAEMDDVFEELPETELEEGAADSGSHSGVEVPGSGSGSGPGGGAAGAATTGSVNSASGVGGVGAGMGGDDDDSAVEEVAAADMVHGRGHGHGHGTVPGPSQAALRERQREREREREREREAAGAETEVEADPGTGTFISSATGSRRRRPVSGQLADRMDLMDEADEADVDVNGDADVDADADVEGDGDGDDPFDDELMDVDGQGHGHGHGHGLGQGQRRRMMGGEDVLLVDADMPLAPHSHAHGHSHVVNSGSSGGSPEGTEEVGNKRKRMTMTAQAPVGPGSQGGNQSQNNQNQNASSSKKGKGKQVQNQNQKQGKNNAAGASGGGGTGGAQQLQFTPAQLITIEAHLDLLVHLGYTVLALNQTIQKKIDPKTHVNVLDILLRQLKPRSGIVFLKRLSVVLDEDSEKGFGLTSSSTPLLSSYDLLSLIPTTPTTLSQACLTHTQPSSSSTGTSVLTANIISLPLTLNKMPFHLKHTLIRTAIRNGAVFEIEYVGAIGGCCEEGLVEGGAAESGNGSGGNNVVKRNWWAAAREVVRVTKGKGIVVSGGVVKREDLRGPKDVANLISLLGVAQDAAHAASTSVPKSLVLRAQTRKTYRAVLSEPRVVLPQGYQPQTSASPTLPSTSGSATVPAPAPNANANANNHPNPTPSSSAQTQIVPASGPSTSSKKRMREEYEDDDDEADVAQQGAGKRKEEKEKEKGQQNGQQAQTQKQKQSQSQGQEQGQGQSQAQANDGKRKKKKRKGNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4X5</accession>
    <name>A0A8H5D4X5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4X5"/>
    <dbReference type="OrthoDB" id="2884999at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="30235" checksum="651A8F06B9045626" modified="2022-01-19" version="1">MIIAANYNHLIKRFGDLDQFHHVSPEIIWLLLPTTLIALTVQSFFVWRIWLFDSKKYRIPVALGIGMAFQLGGNIYTLYVGQNVKNLAQLWAADHVMLAYYAIAACVDVLISAMMIYLLWRRRITDEDVQFNHTSRIIYRLTILSVNSGLWTAVFAIGVLILSVIFDSGLQFSICYFPLAHLYSNCLLANLTTRNYIKTSGEPDLTTLGAFNNVIHLSARSDQDVHDGSESVPRVIISTEIRKRSDLDATAIPDPRYKHDDVAHCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6K9</accession>
    <name>A0A8H5D6K9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6K9"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034982663" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="63505" checksum="13A0C271DA8EB712" modified="2022-01-19" version="1">MWRLVCIFCLSLQAFASISENKGTENALHLPIFKKHAQIKQKRNGEMKAVGLGDFFDATYSVLMTIGGVMTPLVLDTGSSDLWVVSDSCQAGPCSSTEVPLYPQETFESTGLTVALRYGDSLTGTHAFGLVGKDSVNIAGMVLQDQLFASINDTDTIVLETGTAGIFGLGFPINSAIWFQTFSTEHPVSSPQKRYMPRFLSLNFQSSFPTLGIFRGDYPGTAQGTSSEESATTDNTTRRRSLSSALPSIERRQSSSSSWTPVILNSFAQTGPPLTRALAQLGLKPTFSVTLQRDTVKIGGNAGMLTLGGLPEGVDEDSLTWVNVRAYTPAEGGLPPPPDAPDEVYPIAWEVLIDAVYLNDEKLPESTLIDSGLSVSALIDTGNSLIRGPPDVVNKIYTLLGRNGHYPCDQPQNLAFEIGGKLFLVDPKDFGNQVFPDSLELCTANIVPTDVPVKGNGYQYSWNLGDPFLKSVLTSFHYGNISHPSQDPPRIGFLSTVPPDSDKRYLDAVEAASDSRNFPAIFQPAPADLPPISTNSDGVPQAIPTQTTSSLGGPNHSRLENGGIPGPIRRPFSNVEKIVGTAVITGAGIWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EWE7</accession>
    <name>A0A8H5EWE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000495">
        <property type="protein sequence ID" value="KAF5314819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EWE7"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5314819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28821" checksum="B78B2A22462E4838" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGIDFNIWADILLSWLQATGLSSVLSSDRPSDAEVSTVSPLSAEDMAAQTEAITTALKKQADWDEKNDKAIGSIKLCLSPPVRQKTLGMTTAKEIWTFLKKTYGKPGVSAIYTDFKRATSIIIPNDANPSAAVELIRMHFDRVSTAGISTNDSSNTSMTKIPNFLIVMFIISKLPPRYEYLINQYTQCSLQQIDRQSLDELQSEIINIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQQQQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EYM8</accession>
    <name>A0A8H5EYM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000484">
        <property type="protein sequence ID" value="KAF5317440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EYM8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5317440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="140" mass="15740" checksum="D0F6A40A4B91F73B" modified="2022-01-19" version="1">MSGAKRRFVGTLYRDRNTFKCRTTRSSGSSVETEEDYRVCPFLRVTSFFFLLGFYTDFFTSSGLPLIPDKPGLWVCAGHNGHARTFTYATHGYSVVSAILSTTTPGLIKLMQGGIWDKARCFELTQDTLQKMKALEVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4B7</accession>
    <name>A0A8H5F4B7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000394">
        <property type="protein sequence ID" value="KAF5323219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4B7"/>
    <dbReference type="OrthoDB" id="3157337at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="318" mass="36397" checksum="0D8314728D08F16E" modified="2022-01-19" version="1">MNSFVSCLPLEIMDPSPMEQDPELFHPTGDIIIQVENILFKVHTFLVVPRTQVLRDYLSTIENQPVESHEGSSITNPLHLSGVYVEEFRAFLDVIYDLDSILTQKKRDATYYLAVLRLSNMNLWEPGVDFAIQGINSLDPKELQPYAKIVLGVVHHQDTWVFDGVRRLFVSGPVIPQPDDKEIFKQNPSIDQCSIDWILRDGSTLLTNTITELIHHAPRFPNHDKAAWGTFNCDNHAKCVSAVEDKWKRIAKKLPLQFKAANGQWALSFEVVEHLEKFPFRSMDPRCRAQMFSILNHRAVGFYRSICCAICDKLMTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF71</accession>
    <name>A0A8H5FF71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000262">
        <property type="protein sequence ID" value="KAF5334347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF71"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="160"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="45350" checksum="7953C908FA007457" modified="2022-01-19" version="1">MTNASDLRDMTPFFFFLSFPMDAGAPPVSAAPASTDEPDSQDIWNGDVDNFILTHLEQVKKDRKGTWDQFGAAVWTNLSAQLQSAGHRVYSNDELKDRFRLLKKSKTSTTSSAPRPLETPPTSHSAAPLPSISAPLPYAAPSSANATAAPSVPPPPSTAHWTPEAEALLIEHLVEAKAKGQMSENNFKPSVYQSAAAYLREKGYNFTKTQVKGRWTRFKKDFKIVRRLRTLSGFGWDNVRNMVTATDQVWDAYIKGHSKAGPFQNKPFPHYGDIASKHRAVASTPAPKRVHVSAGAQALENMSTAFGSLAEGMKSGAFMAAPVTDSLIKKEQAFNIVCAEEGLSPHSLAKARRVFRGSGEIAREFLSFDPTDENKKEARHCWLLDEMEQLHINGSVFTYLEVSAYEEFHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKH6</accession>
    <name>A0A8H5FKH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000180">
        <property type="protein sequence ID" value="KAF5339942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKH6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="511" mass="54942" checksum="09CD7BD2B3DE8746" modified="2022-01-19" version="1">MPPRKTSSYPTPSPAPLPAPAPPADGNWDLYTDPLYLSQRPLRLTHLCSHIPPFVSDLFHEETCKWLDAMAPKVGARGGGYLGNYKERRPAGEAGEACDGGADADAKENEKTKAVWARDTLDLDHAAYDRFETPFFAFWFGLIPKPKLQDLDKPWEKLTPLIPGNEFLTEMKTGAGADGDAGGAAVDAAADMTTTLPVDPMLTTASTLAEVEDTTPPTTPTPLSLLLPVLLPVLVLLSPPPPPLTPPKLHPTTYHTRANAPTPTTYYPNANTNAPTPTPYTHSPLTTLLLDDYPLKARLQPYTRFCIPEYSRDVWVMWVLSGAEGGKGGNGVNGDKVVKAMVLLWAWAWVANLQEAQEREREEERGIQATDGPTEIEIPTDEDAVTEDVVANTSTYASTDSIVVPTVPTVPNSPVIVTKLKRQRTLNDMGSTVDIFTTASTASTSTSLILCVCEDDCEIVGDGDQIANSNWGGGAVGGTMDMDISMDGHGLYDGMPPPPPSSTVIVLLIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLR8</accession>
    <name>A0A8H5FLR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SLA1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000168">
        <property type="protein sequence ID" value="KAF5341292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLR8"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLA1 homology" evidence="1">
        <location>
            <begin position="120"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SLA1 homology" evidence="1">
        <location>
            <begin position="202"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SLA1 homology" evidence="1">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="381" mass="43520" checksum="867BD11AA675F005" modified="2022-01-19" version="1">MESTEITNSPLSESLVRHSYSVEEDKITRTDDEDSRISTVYEERDEVEVGKRHGVHQSREELGLQLEPDDLDEEQRARRIEILKQLRMRREICRLERRNLEVIEDDSVSESSSQIGPNGAPPKNLIRRWHDITGQFKVDAALLAYKDGNLRLQKTNGVIIQVPAKKMSVEDMTYVKRSMDSEAIVEDDCISQSSSQVDPNGQPPKNRVRTWHDITGQFEFDAALLVYKDGNLWLHKTNGIIIQIPAEKLSVEDRKYVVRLIVKMRRSNRLFQLQKLKTLKGDHRPISTVSSHMDSFSGTPPLASSHVVPGGTPPKNHIQTWCDRTGQFKVNAALLAYKDGKLRMHKTNSVIIEVPTEKMSVEDMKYVQNLMDGKKLVKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPK9</accession>
    <name>A0A8H5FPK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5344023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPK9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="501" mass="57768" checksum="EA70AABE53CD1D7E" modified="2022-01-19" version="1">MSSDEDYEDFYSDYDDYDDGAEDYHDYLPEDEGEGYASPDLDLGEDAASDASDGKYWRRLRGRNLSEYEDPGTFHATHEDVEEYEAEALSAWIDYEGYEGRYGFHEGVVEEDYDCERNFEAPSTWAEPGNYDERLGFYEDAEEDEDEEGYYEEHRHAVYEDQSVNYEGRHGFYQDEDEEGYYEEPHQASYEEQSVPASPEYYDDDTDSDGDWSPQIAPAFQTRYNEISSPLLSHSPRTGEYVPPASRQSYYFPYGQTPQTETATRYGVSIRSISARSESGRWLHWQRTDHSTGEVEVETAQVGETLGQGTYGQGNPSSLPIPICLFRSSVYDLENHRRPLVAKRFFKRFSRATSTEIRNLADVGQLRGVAQDVDGAPIAIIYKQPGDKLRNLQRKHDSDIAGLTQREYKRFLEKTSEAVAREVVEEAKRTGLRHTDAHPGNVLLEYDFHYNPRGTRVTDMKVDAALIDWGLADVVSRHEDWDRMYRRELRNARKNFGLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQS7</accession>
    <name>A0A8H5FQS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQS7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="252" mass="27045" checksum="E041895AD705B7D4" modified="2022-01-19" version="1">MSITQSVQSTVTPDRTSVEKPTKVSEKDMDDEGVAHRSTSPFQFPNRTYVTQSDPFKTISRSTSNLSSYLASWNGKKKVPSRKQLSDIGEAFFVPVPVPQAPQSDNSDTSEPSTLFSGPSSSSSSSPSSSPSVCASASTASLVPTEVCVDSDSDIQDHTVLTVKVVNWDDPEEANEELKRLGIKVRDYAYEPIDSPIIRRVGGTSDVEAEAEAAGEVAEEETKGLAGDVKELTSVTGEEIDREKSCGENTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSD3</accession>
    <name>A0A8H5FSD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSD3"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="373"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5347396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="905" mass="98888" checksum="9D0257BD7039D630" modified="2022-01-19" version="1">MVTRAADSYERTGNPPYLAKNTYILTVSCDTRTPIISAPMASGGGGELAGAVTGAGGFGFIGAAFLSYADLKANLSIVRKTLNLPDGAPLPVGIGFVSRVLAKTENSDDPRLPAILEEKPQAIWFAFGDDLGKYVAQVREYDSKREHKTIVFIMVNSVEEALRAANEWKVDVIVAQGIEAGGHGGSEAPSLLTLLQAVINAIPPDGPVIVAAGGISTGSQIAASLTIGAAGVVLGTRFLFTHECIYSQDKKDAIIQAGLINSTRRTLAFDEVRRTMGWPDKINGRALANDIVRDLDEGLGLEARLKRFDESAASGDTSRLIVWAGEGVGLTDHISSASSFEEIVAAKARMVMPHLSLVVLAITLGTEAHASSQPVVNLPYGSFLGTTDNNVTQFLGIPFAQPPRQYPFKVYEMQIRTVPHVLNKSKHIPRDLVSRLPMQIHQKIVKISTSLTINIIKPAKHGGTRHPVLFLRSRVDVEQLHQGGFEIGDATDTPMLPFVQRSIVIDQPVVAVTANHRLNGFGFLAGEQVEREGLGNLGLHDQRFALQWVQKHIHKFGGDPDKVVVAGPSAGAISIGMHLTADDGKTAKNLFRGAFMESGSLIPMESMASGQDAFDQIARFSNCSDIPDPLQCLREIPYDTLVTAINQTRNLFAYTSLNNDWKPRVDGRTWKQDALCSVNQGFYAKFAYSSPSYELKIPFIAGNCDDEGTTNAEFLQYIRAQYLQRATDDEISEVENAYPEDPTFGSPFDTGTNNTLSPEYKRMAAVQGDLVFQGPRRVLLHHASQTQNTWAYLNKRGKTNPIVGASHASDKRFWYGINTTDFRVTDHLINFINHLNPNGKSENTNSSYWPTWHASKAQPSLLTFYDNTSIQLSPDTFRSDSMTLLTDLEVDVAQRRGLCHNHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV44</accession>
    <name>A0A8H5FV44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV44"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034074231" evidence="1">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="510" mass="57073" checksum="E6A087C0C8595C12" modified="2022-01-19" version="1">MGILAPALIFVLLLRVVPSFASEPSLDEAQQVLSLKMDTSSAVHTGAEGDGVPLKMGIEEGQEVAQEVDSSSSLDTSIEVVSPSEMGIQDGVYVNDFNATACAELHNQIVNIVVNAPHQPKNVLKKFFDAFEDEEQKMRERLSTPLIDFLSQIYVPVLSPEEKPWIWIDFTPLLTMPHPSILWSFEDWELGNEYVLLYADAGDESTGGIFFDMETNLISMVTLPDQFMEDCLWHYPEVALRRYLELFELGKFRLPTNETGVAASDALNLRFEPTQISIQLVDEFSVTAALDTYDALLEAIAQRIPGARIYNKPLVDKRTLIRWKITGLAFEFLSHARTPSFKYIAPGISVFNKDSFTAMMQLNNGSLQQWVVDRDIEEQAPMLLFPGDAPVRVEEEEQYLFNLMHPYLMNNQSGLYSVPGMDFGDTVELILPYSVGHPSARSHSRLFQHGPCPFFKGHNTRLFSLFSNWVRNVESGGFVVGANGVEGGMGAYMLADTEASRIRTDVGVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVJ1</accession>
    <name>A0A8H5FVJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVJ1"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22390" checksum="774BA6A324DB4129" modified="2022-01-19" version="1">MPASRNRRSTSMKQSTLPFLTSRSSSTANATSKTKPQLARATTDEIESTSSSSSDEDEIEFVESDDAEVKTPTVTQRKEPVATKKKVGQASPAVAVSLKEKPELHARDKRWNKVWNDARARNNNLQPVHGEDETKFHQILRVFDMSYEYGPCVGVSRLERWERASALGLNPPIEIRDILLTRNGIEDPTLAENVLHGFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW17</accession>
    <name>A0A8H5FW17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_010381</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW17"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034303028" description="Probable beta-glucosidase G" evidence="18">
        <location>
            <begin position="23"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="706"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5350817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="788" mass="85135" checksum="0AA0431B2F12F4A1" modified="2022-01-19" version="1">MKLKLEALLSLGIALGLSSVFAQWLDVASLDSGNSTKWPAPALTGGKSWGDAYAKASALVANMTLAEKVNVTSGILGPCVGNLGGVPRLGIEGFCLEDGPAGVRPVHGTSQFPSGLATAATWDVDLIYQRSHSMGKEFYDQGVHIALAPVTGGPLGRAPRMSRNWEGWYADPYATGIASYLSVKGLQDAGVAATSKHFIAYEQETFRNQYNRTEPYSIFPAGEQRSISSNLDDKTTHEIYLWSFAEAVRAGTAHMMCSYNEVNQTQACHNAYTQNHLLKGELGFQGSIISDWGGQHDNVASALGGLDMAMPGSGYGQIFGSLWGENLLELAQNGTIPEDRIDDAAIRILMPWFWLGQDQAKLPEVNAIPAYYNGPNGYRDIREAETAGLVRRIGAEGATLLKNSGVLPLKKPQRIAVLGNDATDNAIGTNACGTGYRDCPKDNLNGTMSMGGGSGYAYAPYLVTPLDVLKARSVKTGAEISAITLDTGVNASIQSLLPNSDVVIVFVNSWAVEGFDRADIKLHPNHDALIAAAVNSSSNVIVVMHIPGVVDVERWIDNDNVTAVIAAWYPGQEAGNAIVDVLYGDVNPSGKLPFTWAKSYDDYYPNTIIADAVTAPQSNFTEGIFIDYRWFDAQNITPRYEFGYGLSYTTFEYSDLLLDESTAHSDELAIQETNEAFAESEYTSLYDVLFTVSATVTNSGNVTGSEVAQLYASIPEDDQPPRVLRGFDKVKDLAPGASSTVSFELRLKDLSVWDVVKQRWYVPRGEFTFSVGPSSRVLPLSTVWSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWQ6</accession>
    <name>A0A8H5FWQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Large ribosomal subunit protein bL28m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003120</name>
        <name evidence="6" type="ORF">D9758_007162</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWQ6"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_bL28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_bL28_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5351598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="24281" checksum="5229C3A8BDB9B67F" modified="2022-01-19" version="1">MHPTLSTLKALITSQPFKRSQLGLFQGKTKQYGNNVPFSKHKTRRTWLPNVQRKRLFSDTLQRFVRVKLTTRALRTIKKKYASIDNYLFRNSASTVSHEGLRLRLMMRDAVATRPTAGETQRQFENRKADEVRRVQTKQALRDRKVEVNRAVSAKGPTLEDARKARLAAVEALRGTTSSSEAIKPGQVLLYLKQQQKEQKRLLGQKFFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1G0</accession>
    <name>A0A8H5G1G0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_008273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1G0"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="353"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5356536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="846" mass="93912" checksum="7BD1475A99B9FCEF" modified="2022-01-19" version="1">METKNTWARDDPAILVLLAACLCVSAIVWSVVYSYSFFEAIQLAFFMVARDYLLTGIIIATVLWFVSNKVLLAPPTHSTPADSAVEWAYAFDVHTNAFFPLYLTLYLAQLFLLPLVLKDKWICLFLGNTLYLAAFAQYTYGIYLGLSDPVLSSVMQSSKVSTFWSCWALFPAGVRPPPAMSTHIARAIEQIAEKPPVIQTDFTQHTLDDGTTVSTQERVIKDVQAPAMQIPTPEQFFNNHGQDRSKPDVAFLKNHFYREGRLSEEQALWIIEKGSEILRNEPNVLNVDAPITVCGDIHGQYYDLMKLFEVGGSPADTRYLFLGDYVDRGYFSIECVLYLWSLKIWYPETLFLLRGNHECRHLTDYFTFKLECKHKYSDRIYDACMESFCCLPLAAVMNKQFLCIHGGLSPELNTLDDIRALDRFREPPTHGLMCDILWADPVEDFGTEKTTESFLHNHVRGCSYFFTYQAACQFLERNNLLSVIRAHEAQDAGYRMYRKTKSTGFPSVMTIFSAPNYLDVYSNKAAVLKYESNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLVAVLNTCTKEELEETDDEETALPSSPASPTVDESGERRKVIKNKIMAVGRVARVFALLREESERVSELKSVSGSSKLPYGTLASGSEGIKEAIKGFDDARKSDIENERLPPELYDAESEEGRAILASGSLPSTPAEDQEHVPITPNGVAASIEEAISNGSIPANNVTTPVSPLAGPGSPITPSSPSMGTGATPFRRGHGRQASLGTTMTSPSNRRRSIESTRSLIQDVLEGKEPIPEKDEVVEGLAAKLAGVNTSTGTSGGSTNGNGVGSPSNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3I5</accession>
    <name>A0A8H5G3I5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3I5"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="258" mass="29536" checksum="CFE7993C6BF405D8" modified="2022-01-19" version="1">MIKLLLATPLLEIRPHRLSRKNRIRPTHHLVLFFLNNQRGIIGRSLSAIPPQSRIAAFMGGQLVYMVAYEFENIEGAEERAILKVKDSTEATWFVQAHYRLQTTESHGMQIRLLDSNEFRNQMYTDDDNNWWSTDDPPVIFVFIYSPHTPSSSSKHPLHSQSMSTQSQATPERNRFSGPAPYTNKKPTRRGGKTQKILADIPGPFPIRDPCIRTLGPRKIGWLSVDKLQRSGKTYFVSSVLTCTVHERCTGRLHAQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GBB1</accession>
    <name>A0A8H5GBB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GBB1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50476" checksum="E0DE70A05899F745" modified="2022-01-19" version="1">MMGLFSQAGSHFRGVTSSTSKPQQHGQQPHEDIKAPEDTEPDDTSILDENEGSIILSLISQLRYVCWSFGLYSKGLTDVLTWLIHLDLDLSSSNLPLPRPTHSTRRIVIYLIQRWQCRVGMDLSRVTFPTFVLEPRSMLERITDFMSHPDLIFGAEAFDDPEERFIRVLQYYLAGWHIKPKGVKKPYNPVLGEFFRCRYDYPNGTQGFYISEQVSHHPPISAFYYISPSNHLSILGELRPKSKFLGNSVSTTMEGENRVTLLGKEEDGEYVITMPNMYARGILFGKMVLELGDMCVMKNEKNGLVCELDFKTKGFFSGTYNAIAGKVRHNNTEIGEISGRWSHIMDFKNTKTGAKRVLFDAVKDGQNVSPKWVPPESEQEPNESRRIPKEPEAAIEVAREWIFGSCMSSQAQSPPQGTASAQTKPSPPPTSTPSSPPKEKSSSKQPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GCX9</accession>
    <name>A0A8H5GCX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWI/SNF and RSC complexes subunit Ssr4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GCX9"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="348" mass="39119" checksum="5192FB49326937EA" modified="2022-01-19" version="1">MSLQQAQAEGLCLRFPNDLGFHPQITLDTAVNMLLRATVMAQQNPFSWGWIDKPQDGAVYIVFLNQPNAFPNDGIRWQDSENKFTLPVGPQREVEVTEIKFGFIPGTSEHIAWRCRRRYRFTKSGHPNLYLVHYSRGPQAPIVSSLQHQHVRIYPLRQVMEPSVFVLGDKAGQKVYPNGPPPQNPGPSNSMGMVPGMPMNYTPQQQAMLAQQNNNMEMLEQRRRESERQAQQARARAGNAPMRSRPEDEDSGDEAEVISTRALATTRYKRNHDLMNEVFAHAANGDRNKPPPAPPFSIFSQTELEEKAAKLQAEIEALQARAAERKSLRSSTVNSEPPDGDVPMVIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDT6</accession>
    <name>A0A8H5GDT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDT6"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5363199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31074" checksum="FE6E417AB1C07C36" modified="2022-01-19" version="1">MAIADDLQSLKSFHTNNLSGRVALITGGGTGVGLTIARGFVANGAKVYITGRREDVLKQAAEQTVGLIPLKMDIRDNESIAHAAGILEREEGKLDVLVNNAGVVTPASPFLSDKSAPKNSRLGLSLFQSESSEDWQNAFATNTIAPFFTTTGFSDLLEKGARMRGDHATSSVINISSAASSFHSSLNSIAYGTTKAGLDHLTGTLAREFAIHKVPVRVNGIAPGLFPSEITGVQEEIDRQIKEGTFRRGTVLPPIERSGRGEEIASAAVWLASDGGAYTNGVTLRIDGGLALVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGI0</accession>
    <name>A0A8H5GGI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGI0"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33312" checksum="60B2A289E9F84BF6" modified="2022-01-19" version="1">MPGEPTTKAPEPEHTTGSLFYFVPPDDGSRPYTRVVHSEDDPHPPQNWTSEPRTVQIKNLRGKEDLASLDTTGFQFYRHKSDSSYETFGNEEEILGKYYPETVELIKKLTGANRVVLFDHTIRRHRPGQKDTIHSRQPVARVHVDQTPKAAVTRVRRHISDPDLAETLLTRRFQILNLWRPLGHPAYAWPLALCDYRTVDTERDLAAVRRIAIDGTEGETFAVQFHEGHQWMYLRGMTPEEVVLIKCYDSLDDKDVSVYTPHTAFEDSTTPEGSPPRESIELRALVFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGJ3</accession>
    <name>A0A8H5GGJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGJ3"/>
    <dbReference type="OrthoDB" id="2745898at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61465" checksum="A4C2E4B65BEE23F4" modified="2022-01-19" version="1">MGVSLLSLPNELIEHIVDNLAHDPTALKVCSTINRRLIYPAQKHLFHEVTLRPEGSIKGLDHIGNAFLSFFEEPSHNHLVCLVKHLRVKSFYNWGEGYGRLDPDDLGQPYPVFPRVSQLLGNIEEITIPVTFIESIRDFRADETIAVTLQDDWKSSLVSLLQKPDLQYIRVEHDVIFRNTDLDVCDLISVFFASVPCRHPKLRVGIENHRKTEFSFRQSQERTGTGTRSEVDLGPESRSHELDLVGLTTTFSSDRVFRALSAVPFVNVSQLQTLYLTPPIVPMTHHRPWLESSLQGFLNTYGKSVQYLTLNFDRGSMSYLYADTILSLKGCTALKRLVWNRSIDHDRLREWRVNGSLDAPNSSYLLFIAKSLRTLPFSGSGLGSSQSSQSSLIERLTLDIDHHGDGAGDGAGATTSTSTSSEFQFGCNSDMYIDIDNEAWKMLDEHFSSKARFPYLREFRIVQRFPDPTTSEDLGQGHEDVTSSTNTQAPAPPLSQDHVVDKLKERLCLMNKRGILKTEVMIKERQMAIDVPVHRVSWFFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH78</accession>
    <name>A0A8H5GH78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH78"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40641" checksum="EF46B6DB4849F3E5" modified="2022-01-19" version="1">MDPFFSSPFLTVSRDPSTLSDSMPRKMKILDSWSDSTVEQDFPYQDEVHIDEFIVFGYGLWSQVGKGKIHHEDTGETVEVVIKVFQQSKFPTYNSGAEVAWKEARAYKAMSRLQEMSTLASLKQPLSEESVSSLLDKLVPTLHEVHQCGIAHNDLHVDNVLIETTSTEAGALLFPKIFFIDFAMSAVADDETIAKDGRMIIGVVGELGVKHRHQVVLRWRDRHQDEPYARETFINVHLEYRKTRERKLPLGHYDFVEEFRAMCEGKHLPSVKTKTPSSNVGRNTRSETTVSESKTRRSQVKDASTTVARGKRKASTAEAPQPSEAGSKRRRAAEREVTEMRMTRSQTKAALKRGRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIH7</accession>
    <name>A0A8H5GIH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIH7"/>
    <dbReference type="OrthoDB" id="2940489at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13639" checksum="C79C66627CB91267" modified="2022-01-19" version="1">MGNAELLQSLYAQDPKGGYWYKIWTGMRGIGKELVFSSLMAGSIIVHNASNQDIQVFVSKYSNSNGGDSWFALKAGQSDSWSRNNWEVVAFKKNDDSERAGVYTATNKMITFRSFGDIQVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GII4</accession>
    <name>A0A8H5GII4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GII4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="13207" checksum="C412F7395AE5F261" modified="2022-01-19" version="1">MNTDHPVSALSRHLLKKQHARINGLGGVDSIKNAPCMQPSLATSTAFSHSHSGATASVAYLKAPNRTRSHGAKIALAAAEARPSTGNDQDFQILSLALEPVATILLIGTHVIELSSAVLSMFEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIM3</accession>
    <name>A0A8H5GIM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIM3"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="42"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="480" mass="55257" checksum="1488723BA41E7C96" modified="2022-01-19" version="1">MDHADVIDNTHAAVKWIQNFPRKPTMDRSRWLALLAWLQSHHGMNTNDILVEPRATAGGYGLFALRTCPPSSPLFAVPQSAMMNIKTLSPHYPSGLTAVQLISLHLMLNRPEQDQDSLDPLFGPYISILPRNFDFHPLMQLVKKANHSQELLDQLTPSSAQALEKLAARFSADFDAICRYLRNHPKIIQSSSRLEPRLGEIDSLRLEYVWSWLNVNTRCIFLQLKKARSDPDNLTLCPILDFANHTCQRPQIDVEPNKEKHENGAVFSVLSPRNMSVSADEEIFLTYGAHCNRNLFVEYGFVLHPLSESWDNCVVEVEVDDIVEELFRQKGSVGTWMMEILRTENYWRWVRISDDGHTLTSIARDWTIHSNSESIYPSFRLVTCLRLYNLLPCGSVPANGEESLQSWRRTVIGTQHEISTENEFAWKETLRKICCSIIHRAETWMKHSEQVGSDVMTLWKEELYVARYILKRIRNGEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIR2</accession>
    <name>A0A8H5GIR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIR2"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="796" mass="86655" checksum="D88A377C340FC15D" modified="2022-01-19" version="1">MESLLSFSDTLSNLLVKLNEANSDDDWKQVEITSRILGDGLRVRDGTVDNHTLLGKSSLLQNLLSLYQLALHGSATPSAKYAAPISEILRVAANLCIDHDENRMLLLDANIPQALLSLLEAYTESVPPAPLENPLPLSTLELKVIRTAIGVLLNASVGFEPVKFRLISLNCGTTLIKLSTAVYPLGAWQKLPLNDDTSPDSDLEESWTLRCTISSWVWRTLLDLKDTKDETLQIFSPVTDVLPYLTPSLLPFITPVATEASFVFPSDSAMFSLLLQTDCEVLEESCTQLESLSLDVEDVRLSLARGFQFPAEHSGVPCFTTVLDFIEKGNYSPLWRQALDEADATRKEKTFDMCKAALIKTVVEVVGEERNEEILWDDSEEQKPGGNFVCRMVHWLKSYVLDAESGKGSFSHRTDLVVCASLSLGNLARREKKSLVLLSSPHSLAPILASPHLLSPDTDIKVKHGVLGLLKHLAQSSSQLSPISRILGKASLIRCICDSGVWDERTDVMAEVIQVSAIGVVKHMCNANVENTLALVLPPSREQDPKPVSGLAQILALVKRSDTVTVKSEGTRVLVNVIKTLWSNDIPATASDGSDSSASGAANSEELAEREKRRQEAMRIVLAPQSASALASLIGRSVQFPILVNEGVVALTLLNTQKTGASLVLKAILSPLSFDMLPPPTADPPSASTSVASDVSSPTVATPSTRDRIPVPKTTLDVLISVLKNVDNPVNFQVEVRINSCSLFIQLGKNTSGEEYDKVKDTIRPVFENLLDGLKDATGKDEMLAKSIQKTLETWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJN8</accession>
    <name>A0A8H5GJN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_005694</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJN8"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="314"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5366283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="636" mass="69929" checksum="8B2508808165E3DB" modified="2022-01-19" version="1">MASPSAQGSAGTAPKQASPQVSVDPEQLVYHIDLILLAALTLFVVLRLPRFLARFLNFGELLNGYVLRSGPNRSPQRRVDFNYDPQSGLPQLASDTSHVMYSEKDARRVGPNGAAVVSSYPPHVSSTPSFLRPTLHLLHKRLVPGVSFSHLCVMAVYLGAWIYPTFYKTNAFTDPVRFGWIAVAQIPWLFIFAAKNNLLSFILGAGYEKLNFMHRFVGRVIVLSVNVHTFGYLYKFLLASTFRESIAKPSNYWGLIATICMDCLFFFSTSFWRSKAYNIFLATHIPCAILVLPATVYHKKATLNWIIPAVVIYCLDVLFRLVSTRFATATVRAIPELSVTRVEIPSIRKGWKAGQHVRLRVISRGMGLFGWTEIHPFTIASVSNSPSGEGLVLLCKKAGGWTGKLYDIARGSGGLSSSFAESADRKVTVMVEGPYGGPGHRIFSSFSAAVFVCGGSGITFGISSIRELIAQDLAGRSRVKVIELIWSVQDPSALVPMLPELTAMIQDSVFTPVRISVFYTRAPTGKFPFSDDFFKSTRLTLSPGRPKVSKHLEETIRRTLSPNMNDSTFDLGARSAMGLSGPGRKDMEAMQKKGMLVGVCGPTSLADSVFVEVGRVDSTRVDQVGGIEVHEETFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJZ8</accession>
    <name>A0A8H5GJZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJZ8"/>
    <dbReference type="OrthoDB" id="3221235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="73363" checksum="F9F3DCF17145B00C" modified="2022-01-19" version="1">MSTSASQLRFRDVAVLPPSTSLLSVIVVDNPSRRPNFTVHRESQLQVVQSLGLLVPTTALIWFSGCTTMAWSMPFLLQRLGVRKVSSLYKEAYINEYHNKNMPNLTPIHRILSLNPTSCYRMGGGRVTPLPLRLSPPTFATCIGADQYILLRIPIMSLPSETRLFRPPENNYVSVITLPVEITREIFSYCCTPGLSVEGRNISAPTLILSQTCMTWKAVALGVPELWSEFSLSIDRDHPRTTEDLVDTYLSRSASSPLTLSVSAVPGDEDDEGEYYFKCLWTILESMFGNSHRWKSASFNFGEALLYKFDLFLHPEPESTSSERLYPRLKALTIITTFGSVGDSEVLSGIWKHAPVLQSLCIEGYDEDSPLLFSSELLQSLRFCNSCPSLANAFQLLTNCPNLQEFYFTIEHLEEDDDVLSPSFTHSQLRSLSCEVPSHDLCNLLSSFTFPSLTSLNLGLSIIVGSETFSVFSPMKDMFQRSGCSLRVLKLATGGLFASTEELIEILSLTPTVTDFVLNVSEQLNLLSIEFFQSLSFRDDNGDKPAVHDIILPQLESFRVAGFEDLSLESFDYPHPEAMLTMINSRRQLPTNFSNSTQLRQLARFEWSAFLGRPEIGGQWMDSFTSDIEPGLRALEREGLELSLEIERRWLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL40</accession>
    <name>A0A8H5GL40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL40"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="548" mass="60497" checksum="0DCDEF229C80391F" modified="2022-01-19" version="1">MPSFPPSYPSLELNTQPSIPELLDFHLQHNPDFSLYVFADDDSNGPTEISMLEYIRASHRAGTLIRDAGDSQPGEIIAIIATLDTIVFSAMITGMIKAGLVPFPISILIPPDAVAKLIRENNICRVITASFTLRDFLASVREKLGPSYDCHFEDPPSLSVLYPKLGRETAEDEFSPLSNPSMPSDEDPAMCMHSSGSTGLPKTIRYTHLLIRETRCLNIRLGAFGLAFFHASALYSYIMAPLYGPTTAAVFPPMVTRPDALPVTTTAENIIEHLERTKATALFSQPNFFTTFARSPKVIAVLKRLVFVLTGGGFIPTSVGEHLVSSGVRLRVIWGATECGAPTLLSLEDEEWNSFKLTKEMTIRWVPYGEELFRCHLLTSDKYQPAVENLPYDKGFEVPDLFERHPTKADFWRIVGRVDDVLAQANGQKTLPGPMEDATLASHLVKGAVLFGRGHVHLGVLIELSSGYEIDMNNPSEVDRVRNEVWPLIEGKNKDAAQYSQIVCKEMILIASSDKPLPRAAKGTVNKAASMKLYAAEIEDIYKAAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLJ2</accession>
    <name>A0A8H5GLJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLJ2"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="265" mass="29966" checksum="1E1CA63CEEA03613" modified="2022-01-19" version="1">MPHQHDHNCNHESHDHDHDHSGTSGLGPQDNLFMHIDRDNVVALNANDESKGSDVIKPWHLRLSEEKVIRPPHHCWSSSKLLGHFSSSSLTQTINCTEAHVENPGFYSCFRRIIRIPFTGSVKLRSLLLKTGPTDQTPAKVSLFANEDNLDFSDAADKTPTQEFDVAQGREVGEYVVKYYVSFYDRIWLLTDKFRTAKFSNVSSLTLYFPEGQGADSIRIYYVGFLGTWTERKSNPVITVYEAQANLADHQKIQGTEGAFNTPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLS5</accession>
    <name>A0A8H5GLS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_003735</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLS5"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5367366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="390" mass="41690" checksum="11698E1D8062729E" modified="2022-01-19" version="1">MSTISQSHPSPSKIIAPNAPQPQDSKPKIKVGVLGATGTVGQRFIVLLSTHPWFVIDSLGASARSAGKSYKDAVKWKQVTPIPSVTANLIVKECLPEHFSDCQIVFSGLDADVAGDIEGAFRAANLAVFSNAKNYRRDPNVPLIVPLVNPSHLSIIPQQQSLHSPPLTKGFIVTNANCSTTGCVIPLAALEKAFGPLESLIVTTMQAISGAGYPGVPSLDILDNIVPHIGGEEEKIEWETLKILGGITEKEDGLKAFDMHSSKPLRVSASCNRVPVIDGHTECVSVRFARRPPPSPQQVREALAAYTPDAQTLGCPSAPRKTIVVHEEPDRPQPRLDRYFQDGAGVSVGRVRQCQVLDIKFVVLANNVSIGAATSSLINAEFAVLKGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMV0</accession>
    <name>A0A8H5GMV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMV0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="752" mass="81537" checksum="9308CFAD5D4CA1ED" modified="2022-01-19" version="1">MLTSKNLPSSQKTASSSRKPTYTPPDVMQQHISLGQLDRMKQDPVPHLSKSLATKGTLSRGNGNDSNSTSVLSPTKLSGHRHLRPNPVSADDDDTTDTSDASTYSTDSSEDVMDKLTSDGGVSVFRRNTRNLIDEPDGDSSDSEVDSLWGKLSSGAQSEFDSDSDGGGRPSGRKMMRHAVKRTTQLGWKTLKERFLKELRCKSTKREKDLWLLKHGDSKCEQCRRQGLPCIRRPYGIGCQECGLKNASSCTRFGLEQKDRIMRELKIDEETYKKLLEQFCDVDDDASDSTSDEADPTARPVQTQASVKTPSTTSQKAKATPTVQSTKRKSTQDGRVDQDVPSNQDNLSQPNLQTPPRPSNPHIPLSTQSPRKKALPNVHTPARPSNLQKPRLRAAVLPNPNQISLVGASGQDREPVTSTPRTPKRRRIVPPTDEIELNTENPSPTRPRVSARIPHHDPADHRHADADADSDVDPLAITSSPDTHGPPPTTTVLNVNISMSNEPVPMTRHTSTIWKVQTELPASLMLGISTSATATRAGPSTSTGSDGQGRGVTIQRTAHLPRALAAPPSNYNHELEEERKQLKSFIQIQQKEYLSLKALQRSLVNLSEEMESGAIAAEKALAELEEFGQKIHEMVGSRIVRAAQATGSRGVGGEGGEGGVGGEGGVGGEGVVDAAGMRRPLPTIPMTPMTMPMHIPMPMRMSYSLPMPYNLPMPMPGTSAPGHGYAGLGLSDAHATTVRSTSAPWSSFLMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GND3</accession>
    <name>A0A8H5GND3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GND3"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="689"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="742" mass="81219" checksum="C07B10305E3A75F5" modified="2022-01-19" version="1">MSVCIKLEEQKLLGATFFCARQIPECRDHSLIIPTIAYQLACHLQVFAAALVDILREEPEVFSKPPSIQLNLLLMKPWRKISSANMQTAVVVIDALDECEDISSVLSALIPTINKQSMPGLKFFFTSRPQGHIQKHLKINRPLPLGSQVEGMFLHDVEEQLVKADITKFIKEEFEEFSIPEQDMYINKLAEKCGKLFIYAATMVRYIKNYPEYVEDRLGEILKPTSASEENQTGDLDYLYSTVIEVAIARDPRELSSKEFEERLKILHTIVILVSGSEDDTLRLWDVVTGTQITEPLQGHTNEGHTREVESVTFSPDGTKLASGSWDHTLRLWDVATGTQMTELLWGHTGTVNSVAFSPDGTKLASGSWDYTLRLWDVATGTQMTELLWGHTGAVNSVAFSPDGTKLASGSADCTLRLWDVATGTQITEPLQGHTNWVESVAFSPDGTKLASGSEDHTLRLWDVATSTQITEPLQGHTDSMASVAFSPDGTKLASGSWDHTLMLWDVTTGTQITEPLQGHTNWVESVAFSPDGTKPASGSLDHTLQLWDVATGTYITEPLQGHTESVNSVAFSPDGTKLASGSDDHTLRLWDVATSTQITEPLQGHTDSVASVAFSPDGTKLASGSFNHTLRLWDVATGTQITGPLQGHTAEVNSVVFSPDGTKLASGSWDHTLRLWDVATGTQITGPLQGHTAEVNSVVFSPDGTKLASGSWDHTLRLWDVATGTQITEPLQGHTNRNGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNK4</accession>
    <name>A0A8H5GNK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_004486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNK4"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="150"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5368035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="337" mass="37499" checksum="9EA2465C64DBAAC4" modified="2022-01-19" version="1">MASFSNSFQAHHHSASEVPLFSPEPNRDFLSKPKTSTIQSPIPVQLHEISSTDSRAITRTPSPTPSEAEELQKKTSIGTIDWSKLRDPRNWWYWVIGIIIVVLVILFVVYRDDIINWLEPAAHWLHDTPGGWLVPIAIMIIISFPPLFGHEIVAMLCGLVWGLGIGFLIVAAGTIIGEMANLYVFRYFFSERSKRYEKNIAYACLVRVIQDGGFRIALLIRYSLIPPHFTTTIFAVCGMSSLTFLASAVLSLPKQLVVVYLGDSLAQEADGDASRTERIVNGVVITVGIVVGIVAIRYINRKINEVKPQVIYERRKARQQQKLSAAMSSGSSNTTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNM3</accession>
    <name>A0A8H5GNM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNM3"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114509" checksum="EAAB43548FB0CC10" modified="2022-01-19" version="1">MSSETIPLKIRVDVRDLWDSSTSAVKEAADSLTKTLGHTITPEAEWPALWGELKDHFPDKSGFVLAVSRYTVAWYELLLSRVENDAHLEWTEALLEELSASGRGPLLLKIEPCPANAKTRPITNWNKNTHSFFLGIPKSDLISQTRSSTFFEKDFDSLFGGAPGDSSAGPIDDEDPDLVHVSNADANGKKTSTTVTETVVPVSRTTDVSDLTRRLPALDLLARPNELFKATAPHILMVNQKGDEMTVQCSHEPSLVLLANYLKKWGKTNPNDSLRASHFLQYLLNLQEAMALETLIQLQDSSTESSAATAKKKRRQTAIYPKTNSSNKPQKPFSRSAAKRESVMALGSIEHLQYFFTKAGIKAKKNPLLDKPHHGLVPALGGNQPTISINTNNASISSIGDLPPTPVIPAPPTNVYSHVKTVEVNPESLLPGVIEDLGAVSRAWHLDHDDHDDTPEDSIYFDVLSNLQITTRAIRSIRNYILSFPDERHHTTTTREENFRSSRLTASAAGSSSARTKSPARAGPGGAAAGGSSTSAQAQSQSQQQKDPLTLIRRSALEVLAVLRELEEKARLPLSDDAYDAQSDGGGSHGGRDLSNSGNGGGPPSRLASPSQRPVDLPEGVGLGLHEVDADTSVAFSFVRVQGDKSVPVWEDPDADEFSDEDEKEKRERWDERLVVGSGWLYKRDLTMKDVVKERNLVREYVDTVDEVLFHGEKTDESGRPKERGWVKERRRLINKGGKRRASAGDVGGKAIFMGEPGFRRISTGMLPNIMGGASLSAEPRNMGGIEEGDEEENGVDAPNTSVSTDTSSIDEDELPEWAQKDAYENRDLDRAHALIYFLLPPAFHDALSPSTPSSAEPLEDDNSSSPSSSASMRTAFLDCLSSGQLLCLAYNAGVRKSKKPWGYVNHDGIHDIISLERAEEDNQEKKKTSWTFRRTDNLRLWAGSLKLRYMLPIILPTHVIPITPSTSTGSSGSRPGTPKLGGSTPLNSPPPQVQRFTNTNEPPLLFDAKVVARKDDGWEDMLEAVLVRWMWRVVDERRGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPU2</accession>
    <name>A0A8H5GPU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPU2"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39837" checksum="D3CCB96B12AA1940" modified="2022-01-19" version="1">MGDTPQTFLTTPPFDTISKVRFSPTNPQHLLVSSWDTTVRLYDIGEDTPGGRPSEQKCKFDHRAAVLACCFSDASHGFSGGLDTAVRYLDFESEKANVLGSHNDGVSSMVYASERNALISGSWDRTLRIFDSRAQNPEQSSHETPERIYQMDIVNNNLVVAMASRLFHIYDVRKMQTPAQERDSSLKYMTRSLACMTSGEGIIPSAFWTLMGLTASSGYATASVEGRIAVEYFDPSSEAQEKKYAFKCHRQTIGDKDHVWPVNSLAFHPVYNTFASAGSDGTVSIWDHKIKKRLRQYPKYNNPVASVAFNCDGTRLGVATCYTWDEGEQGAKEQREIPQIWIKTVGPEVKPKDWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ38</accession>
    <name>A0A8H5GQ38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ38"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5368921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="78029" checksum="EE1474A56283A236" modified="2022-01-19" version="1">MQSLQADPENIYTVPTVNRDTVSSSNYPDEKRPHSEEDLVVETYDDHDVTRPFPVDPLAPVETHQLTVRAVFVGCVLGAIVGASNIYLGLKTGFTFGPQLFGALFGFAILKAISKAVPDSGLLGKMFGGEFGPKENCTVQTAATAAGGLGIIFVSAIPAMYRMHLLSDLPQKDVGKLIAMTVCAGFFGIFFVIPLRKYYIVHQKLTFPTPAATAYTIRSLHSGKQGAIAARKKSLALLYTFAACFVFKVLSGYAPGVIYDWHIGWTLYRLGFTSIISLDNYGWWIEFTPAFYGAGMLSGLNASWSFFGGSILAWGIIAPSLVKNGLAFGKSISDDYPLISYQSMTFQEDPSELINHPSPRYWLLWPGVLIMLLYSFADVGLSLLPIFAQMRGSFASNVIGIFRNKRENDEDDEDQTPVEDRVPTSWWTIGLLLSTIMCCAILATQFHMNVGEALLSLILGFLFSFIGVQSSGATDVNPVSTVAKASQLIFGGIGKSTNMQLNDAYMFNLTAGVVSAGAAAQSSDMTGDLKTGYLLRAKPRNQFVAQLCGSVVAVFLTTGLFILFTKASPCIIDDTIVHCTYGAPSVAAWQAVAVAVSSPRLPVPPSSGYTAIALGIFSVISVFAKHFLIPKKYWGYIPNWNAVGLAFVVPQVYYSLAMAVGSTFNYFWMKRNPAGYDMYMFAIAAGLLAGEGLGGVFNALLAVIGVDGGKHGTAIGCPGIEFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSX1</accession>
    <name>A0A8H5GSX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSX1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="467" mass="52959" checksum="E405EFFE71037851" modified="2022-01-19" version="1">MPRPKLYHTKLERQQANCNKSLKHYHKNRDTINTSRRKAYEAEQTAAQLQREEAQQDRCAKIELRQRQQAQKHNEAMSPCVIPVNTLSITYASPFRNRTQLLSQLEEYYTCRLQQMRKPPSMWFDTIYHKYVSETTATGVPSGKLDRVILRLGVTVARIDRLEGKIYQEGGISPEFKKAEVMAWTMRSYLQWAEEMQFALHNCVVFMPTHHRLTLYPGDIEAEARPSQPETSCVSSQAGQGTQSHPVHGFASSLLAAIPRPSSVPPQSSLPSSMPDPPPYTSTSVSSTRGEVTVFYGFNQCPSPQELLEKWPLGQRDAGYVVSRGTRLGFFAHWSIVVALTNGVSGHYQKKFEHFDEALQEYSQVHAGTSLAYPSPEILSRPSALTRPNRLFSYTDPQLQNRDLEFKIDTHQNIRVYAGPRDVPSTVNWVAVQATQEDGHSRDHLGTGALRRQEPIDISDVESEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT13</accession>
    <name>A0A8H5GT13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1187"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="308"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="727"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1329"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5370320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1564" mass="173746" checksum="C767D68CD712B43A" modified="2022-01-19" version="1">MPLLPVPIPEIPAYAALASFCILLLHVGRSRFLQRNRHHAGTNEDEDSSSSEHLKNVKIPGQERNIQFIYTWRVLKLIGCLTMLGLTIGTTIARKCGSVASESGGVEESQGLHPTRAVQLTCLLFVYASCLALLSLSPSVDRRCKSICLVHLEIILLIPFLLYVYRDIVPLGTFDKTPVDLCEGAYLWSKIGVLGFISVIVPLFSPREYVPVDPKNPVESSPDQTCSLFSLMCINFMSGVIFAAKKVDHLPFDQFPPLADWDWSSHLRDKYFKHIDIFSGAKKRRLVWGILRSFWWTYIQAFLWVAPIQGSVSVMGPFALNRLLRYMETDGQNATIRPWVWIIGLFLSPVLEALSFEWYFRILFHTEVRIEALVQQLVFEQALRMRIKNDAALEGKSDVNEDSSTTSTIDDANAGSSTNTDNTNNANNKTKAKAKAKTKDKPSQPQSQDQDAEGAKSNVYGKINNLVTNDLQTFMRLTQVFEGFGTVPVELTLYAVFLYSILGWSALVGIGLTILLAPIPSYLTTLGGKVQAAKMKKTDARVQTFSDTINVLRMVKLFGWEVKMQGLIGEKREDELVFIRKGRTLEMGLGVVNLVIAFVTMGTTFAVHAIVRKQELTASIVFSSMTIFETFGLYIRFLFTTVGTFIAANISSNRITDFLHNTELIDDFTENPSSTITTGDAADAGTGASASPSTSPVPPEHIHDTGFCNATFAWSKDSALSGSGDGTSTPLLSSSRRRFLLKVEDKLVFKQGHLNLILGPTGSGKTALLLALLGEMHFVPPTTANESWVNLPREGGIAYAPQESWVLNQTIKENIVFNSDYNEDRYQKVLHQCALQRDLSLFKAGDQTEVGERGQTLSGGQKARLTLARAVYSKAQIVILDDILAALDVHTAKWVVEKCLAGDLLEGRTIIMVTHNIDLVQPLARFVVTMKDGRVVDQDHVSGVHKSARELVMKLKGELDESEAPKPEDTEDQKAKDGKLVMDEEIVTSRRFLSSLTLYFSALGGGHPLVFLVVVILGFTLVTLTTTFQTWYLGYWASQYEYHSPEDMPVLLYFGKYGLLFVLILLLDLMTNVYYIYCTVRASRFLHQSLVKSITLATFGWLDRTPVSRIITRVTEDIGLVDDTLPRTMQRMFVYTINLLFKLGAAVLFTPIFLLPGVLALAIGYWLGSLYLKSQTSTRREKSVKKAPVLGLLGSAIHGAVSIRAYGVQSTFRKQLHGYIDQYSRASRTMYDIQRWVTFRLPLISGTFVSLLATYLLYASKQSASTTGFSLNMAVSFTRMIFGWLQGSMNLEVQTNSLERIDHYLKIEHEVESTENGQPPAYWPASGDLRVEKLSAKYSPDGTEVLHGISFHIRSGERIGVVGRTGSGKVTIVSMAADTILRIYAEHTHFVSPQPELISGTLRQNLDPFGDHDDFLLNDALRSAGLTTLQEDMAEEDRITLDTAVSAGGSNFSLGQRQIVALARAIVRQSKLLLLDEATSAIDYKTDNIIQRTLRTEFTGDTTMITIAHRLQTIMDADRIMVLDAGSIVEFDAPKVLLENKSGLLRALVDESHDRDILLAMAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU11</accession>
    <name>A0A8H5GU11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU11"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="103"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="37760" checksum="7DBE7246564AE86F" modified="2022-01-19" version="1">MSDKKSESEYNFETYDPPPSYYLSDAKVATTSSSSSFLDRKDSRHYRKPSQSLNAKVATTSSGSSFLNRSASKLGKMFSRNSGNKEALEAMEQILKPILEKYDIVFVIDDSGSMKSSDDLFGSMARGSNRWTEAREALMPIADIANRCDDDGVDIHFLNYPAVGRGLKSAAEVMRLFNEVEPFGGTPLGETLKKITDRYLQRLEQAAEPSKATTQELAKIKPVNYIVITDGEPNDLLPDHEIKKVLVEIANRLGLLQFPRNQLGIQFVQIGDDERATRLLTSLDDSLKDGNGQAAVIDIVDTTKYQKGKKLDTEVLIKSLVGSVNRRVDNEGARMFRGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW92</accession>
    <name>A0A8H5GW92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW92"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44285" checksum="1C7A1AFC0D267F94" modified="2022-01-19" version="1">MGTGAVYVTLSGIKDRNSTLTTIETIFYFLNMALFLLNTMTLAIQAIVYPKQAWRLMQDPVKGIFVPLVVLSFATIIIGTINYAFPTGHVSASLIYALFWVYVTFACVTCFPMLMIWFNKPHDLTKFTPAYAFLIFPMMLVGVVAFNVLKTMDPSDTRAVGVLFVGYFFQGLGFFMTFIYIVIYVIRIMTTGFLDGHQANGAFVACGPPGFTALALINLGDHARDILDIHNLITPQAGEIWYAGSVMAALMLYGLAVFLFLFGVLPYWFKIHKHLNEILGCWALTFPNVGWINTTSTLGGVLNIRGFRTVHLIMTVLIFITWFILIVLTAMAFWKGLIFFSKEEDVLKDTYAVKESDSDEKNWKKLSFSDGHPPNHDAMAPPLHSGVYSANGVRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWV2</accession>
    <name>A0A8H5GWV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWV2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5372521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43839" checksum="8A2EC3CC348E25F9" modified="2022-01-19" version="1">MTPCITSRLHRRTFHQFFQSRCQPEYYQAQRDATLSLMDKLTTDPEHFFGHVSHHSGEILLKTVYGYTLHTEDDKYLQLVHNALEGAVEAANPGSFWVDYFPILKHMPAWLPGASFKRKAKVWGKSFQDLVDQPWNWTREAMEEGTALPSFCTQSAERHSITPGENSKMEQVIKNCAAFAYSAGTETTVSSILSFILVMAIHPDLQIRAQKELENVVGVGRLPDFEDQDKLPFIQVLISEILRWNPVSPLALPHRALHDDVYEGYVIPEGATVVGNAWAVLHDEELYGANPLEFDPDRFLRKDGKVPPNPDLFAFGFGRRICPGRYIALNTIYLTMVYLLTTYNIAKAIDNDGNEIEPRVQFAEGISSHPLPFKCRFIPRNLGNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX50</accession>
    <name>A0A8H5GX50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX50"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="57180" checksum="489EC3FC41CAE70B" modified="2022-01-19" version="1">MYLLSSLLAFFGAIGFLTIYYPNNLVGTKSRQDLPGPKGIPIFGNLHQVYPWRTRIVEWICLMHEKYGDICTFTMPPWGRGIIIGRPEWLLHVKSNDMIKYTRVGPGAEIFEEFPGKNTPIGSDGVDWRRSRKTMAPVFSIKAFTDHVGVAMHKIMGTTTTLLENCSTQDVTVDWNAFFCLSSLSLETDLLGEQPKTLQESDPLRNALTTLSTISSKRLLSPYWKWTEKYTSTGHAFEEARSFVRQMVEDVMSRRQSQNRSCEEDDTTSDYLTILLADPGCNGDLVLIRDTLVTLVFAGRDNTQNVIAWAMNALLNHPDWMAKMREEALRLQSNTDQAKGLPYHNLSQYHVHLAVFYETVRLWPGLPKNGRQVLSDDVLPAIPEAGLPPVKVYKGDCIFWSDYYLMRHPLVWGQDASVFNPGRHLNEDGQFVKPRSPNFNGFGAGPRLCPAAQLSAYEFVACWATILPRFEFIKMYDHEPVMMEAFTACMKGKLDVKIKPYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXI9</accession>
    <name>A0A8H5GXI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXI9"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5372913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="766" mass="85798" checksum="BD0DB68C615B27B8" modified="2022-01-19" version="1">MEVQPGEPMSDIKSTAPTKPPVVRGARACTTCRAAKMKCVGAEDGQKQCQRCKRANVECIFEKHRRGRKPGSKLSEASKMLRRLEKGLNTAKLKSQQSAEGSLQPPYPDGHLSAAQDSQFATNGRGEAFPSGSRFPINQLPPLNLPYANNGGEYSTSSTSSRTMEGDDDDDDEHERSDDVYPAKLIRRENRRNSFFRTILNPQDTPGPEPSPSRGSLSPLHASNGSGLCDPVSAGIMDEEQARVLFDLIFLRLNPFINLFDPAIHSVNYVRSKSPFLFTVMLMAGCKFFKPELFKQCQKLANELAGKAFIEAWKSVEVIQAFACLIYWKDPDDNRTWTFVGYACRMAVELGLNRYVAHPPPHETDLQLRERRNRERTYLVLWIHDRSLSTQTGRNWMLPEDDFIRHAVTWHEKGGSIVRPEDVIVAAFVQLRHIAAETTEIFHTSRNGSPGNDINHEVVLRNCNGKLTQWGETWEREMHRAGGEKFHLSFLSFFRLYVRLFTNSFGIQDSMSSTTRTSPSVSALSACYTSAIENLRIVSKDFATMSMLRYSQESITIMCAYSAVFLLRLLRSASTLPQLHEGASHEVHDVISRAADAYYEASVLSPASNSAAYHARFLRGLLANDIFKSRKPEKTRFDNGGPPLDPRLQASCIQKPTSSPPVYPQRVQDPSFFHSSPAISPSEHNSSDYSAESPRTGLSTMPAPVGHHQGFIPPVPQHTSEMDAQYWRNMFLDLGFGGNVDMAMGVGPHQHQHQNSYHHMQASYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYH7</accession>
    <name>A0A8H5GYH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">D9758_001573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYH7"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="34018" checksum="A32F0FCB407FF6D9" modified="2022-01-19" version="1">MPKAIKEVQGNTLNNFIKVTASTRVKRTATTLSSSSISTSSASGENSSQVTAVSSSSTLVEASPLELDATVAVQLETLEQDTMGKSWYNALKDEFEKDYFRKLKGFLETELKSHTVYPSLQNVYSWSRLTPLNSVKVVILGQDPYHNVGQAHGLSFSVLPPTKPPGSLKNIYKQMATDIPSFSAPKQGDLTALAKLGVLWLNTSLTVQAHKAGSHSGKGWETFTAKALKAVVSRPESSGVVFMAWGLPAQKTCDKIGIDQTKHLVLKSAHPSPLSAHRGFLGNNHFKLANEWLVRKYGEGAEIDWAVLSRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYR2</accession>
    <name>A0A8H5GYR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYR2"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="57281" checksum="693A26DDD9C029AD" modified="2022-01-19" version="1">MPSAGFLIYSGVMPLLKMFLTISFGFVLEKKGMFPISASRGASQVSMNISLPCLLFSNIITSITTENAGALGPLILVASVYVILGFILGGIIRESCYVPRNFWQGIVVATGMSNWGNLPTTVVMTVTQQAPFNPDTDPALGVSYVSAFILVYHIVFWVLGAAPSLAWDYAPGVPQGEETQKYVPWHEKPIGSRLARYLKLHGKPLSSSPLEKVPAFQGSEQNNVVSTGSALEKGIVGDLPSTDTKLSNMCCSEHPDTDPEVQLARRVSRTGSTTNSFRSRRPSVGTSSFLPQKTDNLPAPNPPPPSLASLNNSQISLAPTSSPTEAAHPDGSQEPSSWKKLRPIRALSVIVTPVTIALAVSLPCALIPQVKALFTNATNVGGPHWVGPDGRPPLAFILDTADFAGAISIPLSLIVLGASFARMAVPRPFSKLPITAMILVTLVKTVLLPIIGVVMVQGMTSTGFIEKDALAMRFVAMFLSGTPSAVNQLIVSSLYSPDGNCDTLVAFLLVQYIFMFFSSAFTPTSLEANQPGSVIDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1G6</accession>
    <name>A0A8H5H1G6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1G6"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11282" checksum="7379451D6B011436" modified="2022-01-19" version="1">MSELHPIRRIVTGHNDQGLGCITSNEAVASEILLGGLSTKGRIWTTFDGLPTKDNNNPSADGFKKDIDEANFGLVPNLGMNVQYTELEPSFITPMVCNSCFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1U8</accession>
    <name>A0A8H5H1U8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1U8"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="846"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5375131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1017" mass="108153" checksum="228FE2B65444464C" modified="2022-01-19" version="1">MADVQSTASDRDDKDLAFVAGESGSVAASEEHEVSRGADPEEAATEPPVDPPHPEEVPVPVPEVTTPAEPKPQESDKQSESVSKAKPAVSTKPGPTGKANGGPTTPTVKKVGYNVFNDEISFLMQFFLPQILNSGTFGAGTAKTTAPKAPTAASAPSKATPATSLTKSLSASSTQPPVKSAVAGKTATAPTASAASRRASAVPSKPPAPPGRSTLASSTTARPTTTTTPASVSRASVASSADSDAKAGATGRPRASVSEGVKRTISTSTSRQSLSSSTTKPPVSTASKVTPRTSVAPGARPARSTASISSIREVHADDKAVEELQKKLKETTETLKAKADAVAELESQIEQLKSSLESAKADTEAKNARLTELEEVKSDLEAKLREAQDNVARLQSEHDEGIATLQTVQQELEAAKTSMISQKELIDNLQEQIAKLEEEVIATKEILESLRSSQTSDTSDAAAGALADREVLAKAEGELVALKEEIDALKASHATTLQDATNKAKALEEKAARAEDLEAQVATLKAEKEESANKVSELEIEILELKEGQESADDDHARSKAQLKTLEEELAKASAATQAAIDEAKTKEAELVSQAEDTQAQHNEALESAKQAHEEIVAQLEALKTELAEAQADHEKTKGESQAAALAQSKALEEAEQKFIGKQSELSAEIQRITTELEGQEAHYNAKVDAVKAEHTKLLEEAFERAKTEAGDIHKQELSAVRSGFDDTAAQLKTNHDSTLEGLKSEHAELLEAQAKKYEKEISKLSLDLKATQDDLSKAKALAETAKSEVASLTGQRDEARAAADAPSQPPAELTEEISRLAKELAVTKDDLAAACEHLELTKASMNDMSNNQSRELEEAAKARAEEVNKLRNVHDEEVSALAGQKSELLLKLSDMEGEIATLKATLAAGASAPKSNGNVAPQSPGVTKEELQKMHEAHNLKIHDLEAAHDKAINALKDDLTTAQHQYETSRNEVASKNMEIQYLESDLEEHQEQVSRLKEDMEALNERLSKQTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHJ7</accession>
    <name>A0A8H5LHJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHJ7"/>
    <dbReference type="OrthoDB" id="2859354at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="227" mass="24841" checksum="C03027ABA5F76417" modified="2022-01-19" version="1">MFKMQPSKMIRFQTDEKSSPQRQRLQFHIIGAEDLDSTKSHASTKRPLNAYVGMKVTMSEGHKTHYYTTSTAKCKSPESDVVWYDNLGPMLLPSSATISFEVCTRSSISRTTRFLARTASYSLSALVKMQGDLTDRDSKISLPLLTEPGSPTPQPTPSPSRPILNINIRELASAQLAQAEVKLAQSRLSHDENRRSSIEKEPLSEPEDDLTRGVISGGGGATAATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIM8</accession>
    <name>A0A8H5LIM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIM8"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5358910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="523" mass="56828" checksum="5297B71CB664E7CF" modified="2022-01-19" version="1">MKSRLLCRPFLQIRLLHKDRYTSFPNISNVASKEEFAVCNPATGQELCQVSIASTEDVSAIIDRAQAAFDSGVWSKSPAVHRSKVLSRLARTLEAQIPELAKIESLQTGRTIREMNAQLGRLPEWIEYYAALLRTNQAFVAPTQGKLLNYVQRIPLGVVAQITPFNHPLLIAIKKIAPALAAGNSVIVKPSEAAPITVLEFAEMAIEAGLPEGVLSIVPGYGHITGKAIVGNPLIRKVDVTAGTQTGRVLGSIVGANLASFTAELGGKAPIVIFNDADLETSVNGAAFACFVASGQTCVSGTRLIIQDKIYDEFLTRFLAKVKSIRDRMGDPLNPKSTMGTVISLRHLQRIEEMMKRTSGKVIFGGERMLGKSELDGFDFSKGSFFAPTIVTDIDVKDELWEEEIFGPVVVVKCFSEEQEGVGLANACKYGLGAGIWTSDLSRAHRVAADMQAGLCWVNTHHRNDPSSPWGGMKESGIGRENGLEAFEAYSQSKSTIVNIAPVEESRQSDDWFAEVAEGRRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJ15</accession>
    <name>A0A8H5LJ15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJ15"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="506" mass="56399" checksum="8B601414383EAC82" modified="2022-01-19" version="1">MVEKGKRKRVEPEPSSSSSSLSDVPRSPSPQPAPPKWNRHRAETRPCPICNEPIPLRLLTKHAELESTRLDDLIDSIGLTEIWVDPYDSNLNFASSSSLGLGSFTSVLEPTTTMTTTRRSAARARNTIRIAESTSTVTLNDKGKGKAKHPTAPPGTPTSLDTNLTKTLQTIKRNRKQRHAKLREMTREDEEGYGSNNNRHNRRRGQQGQEFTCPVCLAKVQGDDDILDAHVDACVAGEGRRLEEEREQREREAQARRATSLSQSDEYDNDAGGHVGDVRGTGFHTRDPNAQDVEEEVDIDGDDRILFGDVQFTEGDILGAGQEEDLQVDIEGDGDGEDQGDEANREPDVDVDVDVDIEGEDQGEDHHNPEKTLRDLIAEGRATRQHDTRTPSDNPETVKSRMEEVIGVAESDKVDLAILAAKRRRNKQDLVNALEEKVRLLESMRISSSTSLLCRICLDPYNEPTVSTGCWHTCCRECWLRCLGSTKLCPICKRITAAMDLRRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL01</accession>
    <name>A0A8H5LL01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL01"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="26986" checksum="5B384885D5FFF361" modified="2022-01-19" version="1">MSSPPPAANNNASKRRRGRSRTTRSLSASATGGSGDELSDSPAPPEQQQQPSTPGAGTGTKRNRRRPGKKNKGELPGVNESQDAEAEAEGGGGLPGVDDWPHGDNPGKPIGPLPGVDDWPHGDNPGNPIGPLPGVDEWPHGDNPGKMESPHGVDDWPHGDNPGKLQPPHGVNDWPWSKTDLSNLPGVHDWPWGDSVGDEMMKSMPTFGVDNWPHKSDADDQDHVIKLRLDLNIDVAVELKARVHGDIELALLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL29</accession>
    <name>A0A8H5LL29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL29"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="11">
        <location>
            <begin position="357"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5361162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="60918" checksum="29DA87E892531F7F" modified="2022-01-19" version="1">MRATPFLRNIPRSATSSPSATFRERVRRPGYLSKFAQPTDLAPLFKNGDYIGWSGFTGVGYPKMCPTAIADHVESNNLQANPETKKKFNLFVGASVGPEVEDRWAALDMIARRYPHQVGKEVSKGINAGRIEFADKHLSMFPQDLTYGFYSRNKPKAEHSKPHKPLDWAIVEATAVTEEGWIVPGASVGATPEILQSADKIIIEVNTAIPSLEGLHDINQSFLPPHRQPYLITHPSDRIGTTAIPIDPDRVVAVLESRAPDNTGPNAPETPESRAIASHLIQFLLDEVAVGRLPSNLLPLQSGIGNVANSIIGGLAEGPFEKVQVWTEVLQDTFIRFLDTGKLEFATATSIKFSPEGFDHFYNHWAEYKDRLLLRSQQVANAPELIRRLGIIAMNTPLEVDIYGHANSTCALGSRMLNGLGGSADFLRNAKLSIMHTPSTRPTKTDPHGITCIVPFASHIDQTEHDLDIVVTEQGLADLRGLSPRERAPVIIEKCAHPEYKGLLMEYYDRSLHECLKRGAGHEPHMLRNAFKLYTNMLEHGTMKIKAWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQC2</accession>
    <name>A0A8H5LQC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_003227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQC2"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="62"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="660" mass="71814" checksum="76DA53CDAE0F1C51" modified="2022-01-19" version="1">MGAKKEQKLSSFIRSVKPSKDRTPSPPSPAHSIQPSPTPSHSHHPIHSLQQATHAHLSKKYGKWGRTLGSGAGGTVRLIKASSKNGGMIFAVKEFRPKRTGESEKEYQKKVTAEFCVGSTLKHPNIIETVDIVSENGHYYEVMEYAPYDLFSVVMSGKMCRPEIYCVFRQICDGVEYLHSLGLAHRDLKLDNCVMTTDNVVKIIDFGTATVFHYPGKTAHTKAKGVVGSDPYLAPEVLDKDEYDPRKTDVWSVAVIFLCMVLRRFPWKCPDPKNDASFKAFVNAHPDLSEPRPQKTKPIPIRNNTISLSSPSPELVRQHGHGPTHSLLLVPASNDSPDNSAPSSETQSIASSDFDFDHSSFTSTTSSNPSGSMPRFELVTSPRVTQSTATLPAAFVLGTTLHINGERTVTSIRGPEDPSVLRFARPGNSTESLPAVGTSGSFPGEPFPLVKGAASSGLSEEDLLTPRADTMALPSANLPSTARGTTRARASTFAGPIPEITSPIGLSSTLEEPSQPSKSTATSNGTSKRQRTDSVATFHGGGAESIFRLLPRETRPALRRMLHVEPGARCTLTDLLKGRGKASSLLCGCQLHGQGIEGRRTPIQVQQPTYCVDHDCEPEEEDDGDEWLKGIPPCSHPDVKPNHVHIKVTVDDKHGKRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQY3</accession>
    <name>A0A8H5LQY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQY3"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="285"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="386"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="499"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="63580" checksum="26A8DF464224C287" modified="2022-01-19" version="1">MDVPSETLPVNPAPLSSAHRAVREVAFGSLNGQMAGMTSRLFDYPLDLTKVRLQSQVLDGSARFNGPLDCMRQTWKNEGDLFFSEGSSRSMFGAMFNCATLFLTYREAQSLLKTLTGTPENQKLPVPQLAAAAAAAGAVTSLVLTPVELVKCKMQVQSLVTPAATTTLPGPISILKSIIRTSGLKGLWVGQSGTFIRETGGAVTWFGTKEFVGSLLIARRLGSKPSDSQNPPKLLPWESAVSGACSGVTFNFLLFPVDSVKSAMQTEDELRPKGAVNSVPLSPAYRAMREITFGSIAGMASKIFEHPFDLTKVRLQAQVLDTSARFSGPLDCMRQTWKNEGIPGLYRGLPAPVFGAMLENATLFLSYREAQNVIKSFTGTSENQKLPFSQLAVAAAAAGAVTSLVLTPVELVKCKMQVQTLVTPAPSAATNTPPGPLSVLTSIIRTSGVRGLWVGQSGTFIRETGGSAAWFGTKEYVGSLLIARRLGSKPSDSQNPPKLLPWESAVSGACSGITFNLAFFPADTVKSAMQTEDELRPKGPGAPKTRSTFFGTLVQMYKAQGPRGLYAGCGITIARSTVSSGMIFLIYDELDRIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR90</accession>
    <name>A0A8H5LR90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR90"/>
    <dbReference type="OrthoDB" id="3069822at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="657"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1036" mass="117108" checksum="EBDF5E22AAE8C55E" modified="2022-01-19" version="1">MLWDKIDKKYSSPGPTSWFLDFKEFMSWTLDEKKDPANQIASLGAVLTRLKAYGFTVDDKFRALFLTDRIPQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKRRTGQSSESSLLTRITGDRRKFDSAPNWNNQKAGSSKQKNQDKGKGKQPKPQEPSKTVTTGDANQGGDKKKKTRRSKKKKGSKKGAANLANPEVEADSDSDDDAPLMVTAFMANPFMNATLDPIEISDTDDLPETYCFIDENNDSSLKERVKRNLAKQVRPQTISGYFILTHYERLMINELAQETVDFESFLRVEARHQMTRKLAEIWDYTYNSDGTHTEPYLRAKEDLNGDKDMTNQWFDHEGTIRPIQKQIEEEVEYFCRYIMNKALADMRNHKWIPQQFKKREPVPSKPPSLIERAYWPTPAQSVMRTNGVTINTQFHDTSLYPDFIRTLPFNHTKASSSSSSRKRKAVRGSSSSESSDSTSSDHSEESSFKYIPPSVAFKMWQDRMSHMFTDPILENMKREPDESGNTLKKPRYDAPLEEEAGPSSLADAINVSISSGYLADDDGVSLGSESDVEIYIDGDETMAFWQVFHTSNKNSALIQLPQISMSSDYCESHTALVAIDNCTIITNDVPVFICEQSFVARAHCSTCEKYPLNSICKSKITDEITYWVSDSGASTHITNNLMDFAQYHKLPNPIPLQIADKRSETYLEGVGTVFIEHINEEGVKHTIKLYPVFYQPTCTHRLLSRGCILREGYYEISRDGNPQALFIEKWFPRVLSSETEESDKSTKPVQPSELMRSLHKQGTNNLPPDPVVPLDLDDLFRDQFDDQGPPPDEGNGDHQDIDDGNGSDASSEDHDPGAHQPSDPNDSETESTQSREPTPPPAPEPPAQVPADPVPVQGPQPVNPRNVDLTTGRFINREPNPNQTRSSDRQSRPNWRITDPNMQHSRDIPRGGWTRVTPRVTRSQSRATGSQTVTDPTPSTSQVREESDNEDQSETEPGPSGEIAEFLEQDVLEQRVQQGGWMNIHIIMIPIEIQIQKIKEIKLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRH7</accession>
    <name>A0A8H5LRH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="443"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="871"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="885"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="895"/>
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        </location>
    </feature>
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        <location>
            <begin position="976"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
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        <location>
            <begin position="1179"/>
            <end position="1206"/>
        </location>
    </feature>
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        <location>
            <begin position="1235"/>
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        </location>
    </feature>
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        <location>
            <begin position="1255"/>
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        </location>
    </feature>
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        <location>
            <begin position="1266"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1308" mass="139898" checksum="48C4549E8BCF69BF" modified="2022-01-19" version="1">MHLSIPLPPPHNHSHTNSGPGYPPYPHPHPTREYELVVRQEPKQARMCGVGGKADRRPIDPPPIVQLRVIDPYANAPQYQQQPQGNWPAQASASVSASSSRHRREDASPTPSASSRAGEDRRLSRDGGRNRSRERGKDRDRSRSRGRRASRDEDKEGGRDGSRSHSRGRTTSRDRDDDRDGSTTPTHYSTAGRQPSGPGPSGSYYGPPPTSDPSALPGPNGEAPANLGAYAQSYLQNPYYFMFASLAKPDDDTELHWLKDGRTRCTTGSVVSSLYHLKDPLNNNEDAGFFVFPDLSVRTEGSYRLKLSLFEVVGNNVRHCKSIFSAPFYVYTAKKFPGMEESTPLSCSLADQGIKIRIRKDIRVRKRPANQALAAPTPGSSGPNPSTSTTPGQPQPGQNDKDNNKQGSSSNQLQIQPAPAPGQHQQSQHHTYASFGNFGTFGGAQPQQQQQSQQFPGGVGGFAQPQPQPQTASATAVATTPGPATVGFGTGFGVSGVFHPLAPPSGKNPGSGPLQPLPDELQPDRDKDKDDVVMRDRDGQGRGRRRGGGSGGAPSASGSESGDESGSGSEHDDQSVDGERDRGGGGDGMDVDDGEEDVDDGDDKNDGDYEEPSARRMSAKGKGRSGSGSARTRDRRRDKEKDKDKPGKGSGSKRESKRRRTDSGAGRRPTYHQPIAPWPPIQPAPGAPIPVIPPPPGAQIDQALTSRMGSTPTAVGQNAAGTTSGTATPTGGASSSTSTSRAGQQNVHPPLVPTSADQQQQPIIPPSAPAMPSTPMGQARFDVSVPGYPMNPNQAGFDPHQYQQHQHQPMPPHPPTYPPQPPTYGYPGMPQQPQQHPGMPMHSQYSFPPPATPYGHPPHPTHPHPPPMHPHTPQGYPPYAGGWGAPPPPQPQPHPQLGQPQPQQAQPQPGAPQGQQQPQSQPQQPQTMSVYGDPYAQQMQQQYGHAPVPPYPVGQPMRYDYGYQQPQHQQMYGAPAPGPFGHPHVPPPGYGYMNYDQQPQPQPHPQPQVPSQQPQGPNANVTVSSQTGFTSASGNGNGSATGTPQQTQQQPSTNTSTTQAQPQPQAQHQNLGAGMGVAAYDPYQQPQPQPQQYPSYPVHHQQPQPQPIHQQMRYAPGPYGYMYGNGSAPPTPGTGMNMNMGVVVPSMSGIMGTGNQTGTPAEVWGTPGTAPTPWDASYAPYAPQQPQQQQQQPQTIPLAPQPQQAPGTTVGSLGSPRDRIQLAPLRGSSTVPSIASSTTSGTAGGSSYPAVIHIRSGSRSSPEGSSPRRDSVDRERDRRDSRDDRSRDGRDSERGKKNNPLSIGNILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSC2</accession>
    <name>A0A8H5LSC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSC2"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="254" mass="29034" checksum="CB56BF5C8715D6F3" modified="2022-01-19" version="1">MITLYDVKSTLPPSDPRCGYSPFSWRVQFVLRFKVLSYKHHFLEYPDIEGAAKLLGAAPTATKPDGSPRYTVPFIDNSTTNKVISNSFDIVEYLDATYPDTIKMIPEETRLLQKVFADTEPTLIGQLHALMGNAFTKHASHLVTLRNMELMTARGPLSVLTEQEEKENWDRIKNALGGLAKLMKDEDPFVMGKRVSLADAAVFGRLACIRWIWNKETDEWKDIMSWHGGRWSRLFEAYESLPEVKRYNEAEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LST3</accession>
    <name>A0A8H5LST3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004352</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.500">
        <property type="entry name" value="HAMP domain in histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="413"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="506"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="598"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="690"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="782"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="947"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1537"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1441"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5368106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1688" mass="183373" checksum="707FCC5D944ADBDF" modified="2022-01-19" version="1">MTMASAGQPAMASISSTTPPMASTAPYAEDLSSSSETHYFTPPTTPSPKAKIDHLPFLEHLDRLLSLFTTPAAKHFNILPYTGPTDWYTESILRTLPVIARRIEVAETQVDKFRRDHESRRKRTQEQRGMWHQFSQSQQDSQRNAAKSVNRTMDGYMGEYEMSPPSSMGSAGSPLSLKSQTRSNGISSPNGKSTRRSHRGMSSALEERAKRAGSSGSSTPSPPSDDTVNVHINGASNGIIDEQFTGDDKPTGAGLHINLDGLAPDLSREAREKIFDRRANAKLMFPGQGKPYSAPSAVNADRGTALLSEDTQGYKAYPLFPAFQEGCAVCPKCWTMVTLATYSETSTGRRRRASTGAVDARHGIHSENGFDHAVTQGLLDYDSDDGSPFVVASNGALAMAAQESGLSAVEELRLLKQQVKEVARVCKAVADGDLSQKITVPVEGMVMTTLKDVINTMVDKLGQFAKEVTRVSQEVGTEGKLGGQALVLDVEGTWRELTGVVNKLAANLTNQVRSIAKVTKAVALGDLSKQIEVDASGEILDLKNTVNGMVVRLRALAAEVTRVTMEVGSQGKLGGQANVPDVEGVWWELVRNVNRMCSSLTDQVRSIAIVTTAVAKGDLTQKIEIQVEGEMATLKTTVNNMVDQLGAFASEVTRVALEVGTQGILGGQAKVEGVQGTWADLTRNVNKMALNLTNQVRSISEVTKAVAQGNLSKFVEVDVQGEMLDLKMTVNSMVVQLSTLASEVTRVSLEVGTEGILGGQAFVADVQGEWKMLTDNVNLMAMNLTNQVRSIAEVTKAVANGDLTKKITVNVKGEILELKETVNEMTESLSVFADEVGALLFCLMRQMGSLVLFLTSTRLSCCDRLLHYTLSSNCLSWSLRTTGRHSCGSSRAAWSILSFDLLLLRVSQVTRVAREVGTEGKLGGQALVANVAGTWKALTDNVNVMAKNLTLQVRTIAVATTAVARGDLTQKIVGVSVSGEMLNLVNTINDMIDQLSIFAIEVKKVAREVGTEGKLGVQAEVGNVQGIWQEITLSVNTMAGNLTTQVRGFAQISAAAMDGDFTRFITVEASGEMDSLKTQINNMVFNLRDSIQKNTAAREAAELANRSKSEFLANMSHEIRTPMNGIIGMTELTLDSDLNRSQRESLLLVHSLARSLLLIIDDILDISKIEAGRMTMEAVSYSLRQTVFGILKTLVVRASQNNLDLTYDIETDIPDQLIGDSLRLRQVITNLVGNAIKFTPSKLPLMKGHVALSCRLLACDDQNVTLEFCVSDTGIGIAKDKLNLIFDTFCQADGSTTREYGGTGLGLSISKRLVSLMQGNMWVESEIQKGSRFFFTINSQISQSSLESTLSKMSSFAKRTILFVDSLHDQTGVVHRIRELGLKPFVVHDVASLADKDKCPHIDTIVVDSLIVTEQVREFEHLRYIPIVLLTPSAPRTSSGYYFPRTSSSPPHSPATPHPYKHSSPTSYPFTVTKSSSKPPPSNYSCRSDSVKWCLDNSISLQVTTPISAQDLASALITALESNTVSPVSAPTDVVYDILLAEDNLVNQKLAVKILEKYGHSVEIAENGHMAVESYKKRILMSRPFDIILMDVSMPFMGGMEATELIRAYEMHNGLPPVPIIALTAHAMIGDRERCLQAGMDDHITKPLRRADLLNAINKLAGERSTAAKNPLLRSTGRVSHKDVMHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVJ5</accession>
    <name>A0A8H5LVJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVJ5"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="538" mass="59871" checksum="CA6435678A75C7D7" modified="2022-01-19" version="1">MSLHRGAACIDCHRRKVRCDGATPACGRCVAGGHAEDCEYTCGESQSRVKTRVKTLEDNIARLEAKIACLERKKARATLSQPLQDIQIPGRGGAQYSPTRTGFHPALPELPYPSLPQDWTERPILPLEIARILVDIFAPHAFNHGFFLHGPRFLVKMFPSDGSPSSLPLSLISVVYLWGIHLSSHQPWIAHEETFLNRAFVQLLKSQHPNQIVANIQAEVLLSNYLLRSGNFSSAMHRLNSALSQSVACGLHRPGSRSTGANFVLPPPSDGLELGERIDAFWTIVLFHKSWVAALQWPSRISTVLDDMIYVPFPLDMSAYESGKLTFNDLSSPTLKQFLDDPQDEGVVSTLALSVQSAYMFERACYIGVEWKSVLGITEEAIQFLVFDSRLSDFIRTLPTIETYPERFRHAWIATNSIVQAAVIQLHGSVDTSESQSRCLQAAEKIVSMIQTIPPELEHVNPILGTMWFIASRALISALHRLGKAEVTEDTVLHTANIKLSLKTLLETMTTYSIKCALIYSRLGHTQELCRQHGIQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW35</accession>
    <name>A0A8H5LW35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW35"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="5">
        <location>
            <begin position="687"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5371722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="901" mass="98875" checksum="9D6A7EDBC11D00E6" modified="2022-01-19" version="1">MAISDRWPGSAWAFWALHPSSKGLEVIKYFPDRLKAFAGKRIVIDGTLVTQRLHFAPVPHPYRHIIGWYRLIKELEKFGVQTVCVFDGKERSTAKAREVIRRRQAQRLAAARGLIEDERLKRLTQLHDVLGQLSQLSPAERLQLSNHLQREIVQQQPIPTYPNFSDPFWSQHISSVSFSNDDIDTPDFHRVDYRSLFHEAAERRAQAWEEEEEAFYQDLDSHSYSKSLSVPNNPSTYDYDSIPNNADIEVSHEHEHVSIASTSQSLSHSQSQSQSHSRTEYTEDLSISSEDLPVLDTTTLPLPSSTFQSQASPSKTDFPPSSDIGVSVPDLPSISEGKAEQVVDLPDSTSVPNPPTSDLDATSYSETKPSPTNLDTLDLLEPTPVPGPTPHDVDPTSYFQTTTQPSVNETETEADTLDSPDSVPVPGLPTHDVDVDRTSYSQSQTTTQTQPLVTETEIGTEADTSSSSSLINRLASTLSSLYLDYRHSISKMSSIPLSSQTQPDPSPNSTSDGSGAGGVTRRAGARVGVVASGSEQEQEQVKAEYDMSRKQHKLTLEEGEVWDRITGFGAAEAAAATSPAPPSESLDSESAGDGVIVEVSIDTDTQTILDVDSREAQAMEVEVEVREAVPQSEEAPISSAPTPVLRTPEEEVLISLTEKSSLMSESYKRSAQTPTTRTYNECKEILAAMGVPCVEATGAYEAEAVASSLVLNGYADYVASEDTDVLVYEAPLIRNITNRNAPLVVVSGAEVRDVLQLTRDMYIDFALLLGTDFSQRIKNVGPARALKFIRAHGCIEKIVEEERKFSPRVPKEDYMMQVVAGRAVFGTLPPITKEILDGMMKRQVQEGGDEDVKARFVMEKYGLSSVLEWNWEEGLEGNYFGGESGGGGGYFGDNPSSGGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX91</accession>
    <name>A0A8H5LX91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX91"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="336" mass="36916" checksum="72A6C83393AA57B3" modified="2022-01-19" version="1">MSKILPVLTFPVLSAVGLTFVTYHPFASGFISKTFFEECANLHNPNRLPPSGYPFVDQGLCALISLFSAFFDQSIFLLWLLTAIVPIVSFMALEASRADRGAPLMVRNPTLPGMLIQTMSFAFTAPLYWLSIIASGRANMRLSFTSTVSKEHAQAIFLAVLLGLVAPTFYMMYFQTPSTTVAFLPFPVFVAIVHDLYIAFTGSSSKSGYSYIRALYILNFLANFYVHLSILLPNINSLQSLKGLFVPSTSLIDLGEPASAHALHMLQWDMYIGIGSTVFATLWFARSAGQFLGLLLWNLVAVPIFGPGAAFAGAALWRESCLHSDVVPRNKKRGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXK1</accession>
    <name>A0A8H5LXK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="8">HIBADH</shortName>
            <ecNumber evidence="3 8">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 8"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXK1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="202"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="350" mass="37359" checksum="0C0033F3EFBC6EB3" modified="2022-01-19" version="1">MRPSPRRLFQSLDRLAMRPKSYSFVGLGRMGYEMAYNLFSKQHAQASDSHFVVCDVVPEASQNFCQNFLKQFPGAQISIATSPEEATLASQTVITMLPSSPQVKSVYNEGIIPTLRSLPEELARTTLCIDSTTLDVDVARTVAKNVLQTGAQMVDAPVSGGVTGAKAGTLAFLVGGSESAFKLAYPFLSFMGMKIIHCGPSGAGLGAKICNNLILGVQQIVVGEAMLLGNKLGLDPAVLASVVSSSTGNCWSISTNNPVPNSLPGKSPPCERDYEGGFATGLMLKDMGLATNLSSLAGTPLPLGEAAECIYNQVIQEQPTLGKKDFSSVYQYLKNLSEEGKKVRVRYETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY70</accession>
    <name>A0A8H5LY70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY70"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol phosphatase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="336" mass="37286" checksum="AA5F8F505E7B0922" modified="2022-01-19" version="1">MMGDFTRTGRRDLSGLLNDGVNSLARMYTSTFSDWFSQAVIDYTLGNRTISVFSEFLNKLQSSDPRDLIRLGKIRAEAIGDSVSRCLSEGERLLKGWTLFAPEELNVRIGDKFEEKVLLLSYDYTLEKVKRYTRVPLGDVIGISKEEASRDPIQNAGFVVSWLNNNQVTRVTNYSVRNRIEVKRPSVNAIGGGMNGNMISATATQLKRLSMTLGPKRGANMVKVADAEETEEKDDDVSFAAFKILPIDPARVRRATSMGGGEEYTEGADELEGAQNCKEAVEMVVDSIRKACEDVGVAEAEFLKDEDVVGLAEAQRMTSMYAKMEYGVKRLLWLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYH6</accession>
    <name>A0A8H5LYH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small heat shock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYH6"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="47"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5374227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17768" checksum="7B8BD3E882AB2EAC" modified="2022-01-19" version="1">MSVYYYEPFYNFDCFFDEFLNAPCSGNNQQRIQQGGQGEGGNAVAQALKPRMDLHEDSEKNIVTAIFELPGMKKEDINIDVHNSRLTVSGETKVSEEHQDSNRWAVRERRFSKFSRTLRLPQGVKDDEIKATMDHGVLNVTFPKAAPEAAPKKISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZH5</accession>
    <name>A0A8H5LZH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="10">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIF1</name>
        <name evidence="13" type="ORF">D9758_000092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZH5"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="116"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="10">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="124"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5375262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="596" mass="65876" checksum="24E4CB6D0E217B0D" modified="2022-01-19" version="1">MASMQSRPISRPQPEIIHIHDSDSEVECLAGPAAVKLDNDSDIEILDDPSITSQPLPTTTSHPVAGPSRPIPTKSPSISTTSAPRPPSPVDNTSTAPPPEIKLSPEQNHVLERVRNGRSVFFTGSAGTGKSVLLREIIKLKGSSASSSLAITASTGIAAVNIGGTTLHSWAGIGIGEEDPKKFVGKLRGQPKMRKVWERWLNVRTLIIDEISMLDGVLFDKLEEIARSVRNSKEPFGGIQDWQLVLSGDFSQLPPVPNRNSKIEPTFAFQARSWIRCVGRAVMLSKVFRQKDQDFVDMLNDLRFGIVTDHALRTFQGLSQPRHYSDGIEPTELYSTRYEVDKANTFRLDALPDQARTFYGMDLPGQDANGRPVGQDAMNRLLERLIVPRSITLKNLQQGSLVNGSVGQVIRFSTAADALKEGVQIGGSEQNGGERNQRPEDDPAVKQNVQNGREWPVVRFINKKEVLFIPLDFTVDNAEGKVEAKRTQIPLILAWSLSIHKSQGQTLERVKVNLGKVFEKGQAYVALSRATSLSGLQVLHFDASKVRAHQTVLDWYKNNAAAEDEDMDEVDDFADDERIINEMDDEEAMMAYHDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7J5</accession>
    <name>A0A8H5B7J5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018545</name>
        <name evidence="1" type="ORF">D9758_018547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000458">
        <property type="protein sequence ID" value="KAF5318212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000458">
        <property type="protein sequence ID" value="KAF5318214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7J5"/>
    <dbReference type="OrthoDB" id="3158924at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5318212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5318214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14468" checksum="D9DE9D07D90964A5" modified="2022-01-19" version="1">MEKCVEGMSEMYAHMKLMDIENADLRKQAFERTTKKKAVYFEGAHLMTSLEMLDPKQLSGNDSDVPEDKCIIASILGHQWSWGVLVFEVAWEDGDVTWQNLESVDDCLALDVYLQRRGVERPQDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BDQ4</accession>
    <name>A0A8H5BDQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000406">
        <property type="protein sequence ID" value="KAF5320573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BDQ4"/>
    <dbReference type="OrthoDB" id="2425321at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5320573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="40763" checksum="4E6E5CF59D4223CA" modified="2022-01-19" version="1">MDSISTFGLSHHSLESQDGVKKKASVDSFNVEASGDGEDLKLPVRVAQDIAAFVRDKKINAGCSSDGKREIWRSECFHESYHYGINKLWRTALLTASRNLRQNVLRGRIWGFEDESNPGPVFSPSILSPVPSVATTPFSSVRGIGGLEEMAADDEEQDDESTPNKNTVNTGSTRRPLPTPGSSPSVSANTSPNALAVPMQTGSAASSRNNTMSKSGNRHAFVTGTNPSNAGSVRVRGVSGLLDDFSESQFNGGEKAINLLGDDEDEDGDTHARTGTGSVRFKHTRIPSDHPNFPNGLPTYSSSEGGSGSSASENSSGSERSSSPENANAMDGRQSSPSSPAVLTKKNRGGKSLRVKAKAGKARPSSDMMLGMQVEEGGGRKGTKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BHT5</accession>
    <name>A0A8H5BHT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000399">
        <property type="protein sequence ID" value="KAF5323146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BHT5"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="169"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="401"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5323146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="113188" checksum="33E7B3E3B6D12B5C" modified="2022-01-19" version="1">MHEQRGERTPFYTSFLAFTSSLVVVGSTASKPPAMSLGFQNLGLFSLFSVLFLSASLSVSAQNIRPGAIPLAVRSPSLSAWLSGPQAPSAWPQFWTQSRTLGWSGLICVDGQLYEWLGLAFEGGGLTLNQNPKISTASLQSIQITPTQTIMSYTAGNSTNNNNLGQPLISFNVTFLSPIEPGDAALQSLEFVYVDVDVESLDGQGHDVQVYQDFSGEWLSSDNTSPIKWTITTSSSGPAVVYHSAQKQAPQSMVTNNEMAEDVTLYHATMQTSGMTFQTGDHHVVRSLFLNSGTLANSQDTAFREISDTFPVFAFSQDLGTTTSTGSSPMVWAVGIVRDRSINYPESGGTQGLSPAWKLRWGSVGEAIQAFLADSSDALSRSMALDAKILSSSSGGAGGISSQYADIVNLAMRQVSGGLEVTIPPSSTSRNDILMFLKDIGISERAQPVEVLYASWPAMMYVNATWGRYLLQPLLMYEGSSGLYQTSYAAPDLAAFMQRIPLTHRQLDPNVLRSLDDTSSMLIMAYTHARFSGDGSLIGKYYDVFKTWTDQLVPNALMPNGFSTSDGQSSANMTNLALKAILSIRAMGEMSDAAGNEDDAKKYRDQATGYIQQWVSLGTSGAGHLTSTYGDASSWGLMYNLYADKLMGTRLVPDDNAPSFGLQYDSNADDITKSQWLMFAAATMTDSSTRDTLISQVHAKVVDQKNVGVFPTTYNVNDGSPMTSSASAAVGGMYSLLALTLQAQSIRNIKGDFNSSSKSKSKAGAIAGGVVGGLAFIALVALGTFLWRRRARRGLQGVKSTNAKNGAPDGLDGLSGQPPHPSQTDQIVTPERQILMAEYDIGNNLTSTSPGPGTPYSPPANVYAMYNDSPSTSPSNVNLIGASAYSLGGDTNAAIENQQRNYSSLPPGAALPRPASSHASSITGNGTGGRSPLVLHNVDSDERPALDGTTRPMSSSSIATTSHSTSMQFSTPQAPPLPSKQPIRLSVGMEVGYGAGAGTGVVASGGGSEAGGTGLGHQVKGNVSSQAAAMQGHETNGNLRDEVELLRREMAEMRSRTEYEPPPGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BI23</accession>
    <name>A0A8H5BI23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000389">
        <property type="protein sequence ID" value="KAF5323672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BI23"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5323672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="854" mass="93599" checksum="9538747949322E22" modified="2022-01-19" version="1">MALQASSDNWIRRITSLCVLDGHQQHFSMSSLIERISGAKHSAHDLAKVTKAFAEEKLIDVKYVDLEIQFIGASNIPKMDAFGLSDPYFVASLHSHVLSDTSSLSTSSSNSNYTLKDKSTSRISFVSSVQPHTLTPVWNELWRVLNVPSTSDLQVEVLDKDLGSPRDDYIGKFKVSLTPGAKEAEIERSGLNLGALVGRKDGGTFWLKINSKPSVMPPDRMWLQFTDVVLFVSTQMPLRPLTVSILNLNVLDTLLNVPYCAIHISILLPAFHPNVSLESTSAPQLTTNVNSNIDCNSYNISIHSTHPTSYSIHFSPTIGLLTNLPDARLYCTWKMYLVGVGVWFRERVDETAGDSEKPLPPVPGQPQQEQQPPPLPPRPNQVQQQVQVQFKPLIQHWNTQYRAAQSIFGSGPTSFAVRQGIMAGHRMLYARSTRNGFGVLGGGGGNGNGNGGTGSTTNANPDPHHHGGGDVDVDVGRPTPDEVRRIEEDLKRLLRGSVNVNPNMPNRGEAEASDSPNNTNTNTDAAASGSTSSASRTRTSTTANSGGNTTSKSPTRIKPTIYTYIISAEDDSFRFSETGAAFFVDFASKHALHANCAEGVRYSGEFHPRPRILRPDPSNPGQQVSLGWSAFDESIPDDSVEWELVFDNNSGTYAPDKKLLGRLKGLMEGNFCGGEVVPGDERKYDRGYEELTREGTDKDKTDTKSPSGLHIVVYDREDPRLKASVDATKEYALKFRGVRKEEFEPSVGEGEVTLSAKASTRRPGMGGTQKQTQKTDPKEKMKEHLKRLDSSPDGMERIGEFGVEGYADEDEGEGETNEANTTREGSGSKSEETKGLKDKLDRVEERIKKMGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVA2</accession>
    <name>A0A8H5BVA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase beta palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVA2"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase beta palm" evidence="2">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5330075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="145" mass="16109" checksum="F626B9961A2A64EE" modified="2022-01-19" version="1">MLHLSEYEKTTHTSLTTSAFNCLQQIPSALEFLAHFAVRDVVSESGMPRCCLGLALLGRRMGTLESFSQSEREDYAYTRMPRSNAKPSIALSLNPNLFVDIMGSYRKGKADCGDIDILITRDTGDSRTHQGILKRPQKNSPKPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVJ8</accession>
    <name>A0A8H5BVJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_016434</name>
        <name evidence="10" type="ORF">D9758_018141</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000332">
        <property type="protein sequence ID" value="KAF5330108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000297">
        <property type="protein sequence ID" value="KAF5332949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVJ8"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5330108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5332949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="20218" checksum="7C6E9E32F56DF907" modified="2022-01-19" version="1">MNRGFRGSSRGGGRGGGRGGFQQRDAGPPDTVLEMGSFMHAVENEMLCSSLMPDKVPYFNAPIYLQNKSVIGKVDEILGPINEVYFSIKMSEGVVASSFQKGDKVYIGGDKLLPIERFLPKPKAPGGVTKRGRGARGAPGGRGRGAPRGAARGGRGGGRGGFSDRGRGGGGGARGGFGGRGGGGFRGGRGGGRGFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C1E3</accession>
    <name>A0A8H5C1E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000309">
        <property type="protein sequence ID" value="KAF5332363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C1E3"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5332363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="220" mass="24678" checksum="708043D8802D6B0E" modified="2022-01-19" version="1">MALKVYAFPYSTCSKRVATVLYEKKIPHELILVDLSKGEHKAPSYLEKQPFGQVPYIDDDGLILYESRAICRYLEEKYGQGQGQRLIPTDPKKKALFEQAASVEMANFDPYAGRAAYEAVIKKRLGQETDQAAHDQAIATLNVKLDVYDKILEKQKFLAGDEMTLADLSHLPYGSVLASGGNHIMTDPKRPNVARWWTTLTSLPSWQTVQVEVPTGVVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2Z0</accession>
    <name>A0A8H5C2Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_015177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000293">
        <property type="protein sequence ID" value="KAF5333007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4771"/>
            <end position="4994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4114"/>
            <end position="4607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4619"/>
            <end position="4638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4645"/>
            <end position="4669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4160"/>
            <end position="4173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4174"/>
            <end position="4220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4226"/>
            <end position="4293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4294"/>
            <end position="4306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4307"/>
            <end position="4324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4341"/>
            <end position="4371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4372"/>
            <end position="4381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4393"/>
            <end position="4404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4406"/>
            <end position="4417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4463"/>
            <end position="4480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="4487"/>
            <end position="4505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4564"/>
            <end position="4573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5333007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="4997" mass="556299" checksum="BEDF1F2E780455AB" modified="2022-01-19" version="1">[encoded data, 4997 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4X5</accession>
    <name>A0A8H5C4X5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4X5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5334057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55116" checksum="90A03794DC511F4B" modified="2022-01-19" version="1">MIEHYATNLLAMLVFGFIVHRVLRYRRLPLPPGPPGYPIIGNIFDIPPKSSRGWVTYKDMSKKYSSDIIHLDLLGTPLIVVNSLKAATELLDKRSSNYSDRPRMTMLCELVGQSSWNIGFMRYGDFWRAGRKVFHQELNPRALVTYRSSITSATQKLLLLLLDKPDDFLNHLRYMAGATILSIAYGIEAQPENDPFIDLVEKALQSIAFAANSGSYLVDQLPVLKHIPDWFPGAGFKRQAKEWNKSASAMAVVPMEFAKDAIAKGDFIPSVASSALEKIASEPSSPMTHRQPEPEKVVQAVLATMYAGGADTTVSALGTFIHGLVKNPDAMRKGQLAVDERTRGARLPDFSDFGSIPYVDALLRESLRWIPVVPLCVPHRSVEDDEYNGYHIPRGANLVGNSWAMLHDESVYGPNPHLFNPERFLQEDGSLDPNVPFPDPAFGFGRRFCAGQNLAISAMWMAMVCILACFDVTHAVGEDGNEIEPNVEYTLDFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5M8</accession>
    <name>A0A8H5C5M8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000243">
        <property type="protein sequence ID" value="KAF5335433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5M8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18218" checksum="513C0C5524821E09" modified="2022-01-19" version="1">MDDESQSVANVQTRDRSIDDITRSVPTKTKPPTTKPPSASKQKDWPKKPQKGLQRTLPPPPPLDLSMAARYGQAADSHRKERSRRPRLGSKGRDIKMDQFTLSFHGRLLIEGGELSEGLTILGANGTGKSTLLKFNLNITGSLPPSPVTAHSALKLAKHFSTLCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5W9</accession>
    <name>A0A8H5C5W9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000253">
        <property type="protein sequence ID" value="KAF5334718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5W9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11360" checksum="2313D3845F92E460" modified="2022-01-19" version="1">MSSSTQITVQESLAIVTTTIIATAVIKTALIVKELKDVLTDLRGPVIVEPSSLAPSCMMQLGRSVFQSLALMFWVSFIIGFLIALVEYALGYQITQRRALVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C634</accession>
    <name>A0A8H5C634_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000237">
        <property type="protein sequence ID" value="KAF5335643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C634"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20649" checksum="F7CCBD81469BA227" modified="2022-01-19" version="1">MSAITRNKQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFARRNQLTLLPIKDPFPVRNVDGSENTMGWVREYTIQNLRIYSRDSKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKTLKTCSHRSENPSQGVPSQVDRTSWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBT0</accession>
    <name>A0A8H5CBT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBT0"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5338221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="665" mass="74651" checksum="032D351A1FE578D2" modified="2022-01-19" version="1">MGSHSQPIKSRGHLAQKKACLGCRSIKVRCDRAEPDKVNSSIQCTRCARLQIPCVVQEHHRGRRTAPGARETFSAMNQDDDMLVDVGQSSHRVPSQETTQSRPPSSVNSSSSSSYTPPSYSDLCNNTTETDSAHRDYLRAPLAETLNRQQTTLPSPGLGQDPVSVRYLTVSEAKSLLLFYMTEMNQIYALLDPILCTFEYVRAKSPLLFTAILTVAAKFEMQGKYPILLTFCQDLLAKTFIVGTSSLETIQAIRILISYRDHTDHSSYVKLGFCIRMAYDLSLDQPHKRPLPDDETRAREILSGERTWFELVSTDEAISRQRGRPVIISSESVQDPRRWVEENAKYRLDTDPFIAAQTSACGQEYGTFSKLFAIDPPSFSSFAQRQELQLAAARRAKQWTEIWSRPSQEDYRFPIHPTCLATLHFFRCMLDFHVAEIYYRHVLYRPEGVNDLGKEFPALVAVYGAAIAMFQLFSDEFGDGSLRYAPDYMLIGSAHVALWLYKNRSKMHDTTKMAVLTVLKGAMQQFCSSAKADHEGAAYQARFLDGLIHAIEMENGQGSSPCSGSEITAANTNDPHIPVRQVRQMPEQQSHDVPLNPDFPSSVAASMHTYSYPAPPAQEYNIPVDDSFNFLFQDTQAPQAAGFSSLFNIVPDSSYWANLFPELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CC88</accession>
    <name>A0A8H5CC88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_012046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CC88"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5338823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54392" checksum="F2A9FBA35CBA09E6" modified="2022-01-19" version="1">MFSRSKNPAPLPPGPKGIPIVGNILDMPSEREWITFADWGAQYGGISSVTLMGQTMIIVNSTEVMEELDKKGSLYSDRPRLEMGGELVGYSKTLVLVPYGNRFRNYRRHVSKLIGSNNAMAQFMPMEELETHKFLKRVLADPNPDELSQHLRKTSGSIIMKLIYGIEVQEKRDPFVELIEHANDNFSLATKPGAFLVDVFPSLRYIPPGFPGGGFHALAAKWAKAFNDMVEVPYSYAKEMIANGTAPVSFVSTSLEDEAKLTPEEIFEIKHTAASVYGAGADTTVSDQYAFFLAMIRHPEVLKKAQAEIDSVVGNDRLPSFSDRENLPYVNAVVTEALRWNSVAPTGVPHRAMDDGVIAGYFIPKGSIIITNLWYMLNDPSIYPDPFKFDPERHISTSDKPAQRDPRTICFGFGRRICPGLHLAEASLWILIAMSLAVFDIKPAFDEEGKLIIPEHELTGGTISHPKPFKCSIKPRSEKAVSLISAELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGW4</accession>
    <name>A0A8H5CGW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGW4"/>
    <dbReference type="OrthoDB" id="2757214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034643619" evidence="3">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="35003" checksum="0D8DB7C10E295708" modified="2022-01-19" version="1">MLPFPLVLSFFITVFCSLLSVIAEGNVQCADGGLDWYTNVVGETPCKTYERLRQICDPQYEVGRLNRNTPPDICKRGHECCCNSISFGLSMLCLSCQQGFSHDPTGLDAVNGTYKTYLNNCSPVTNKSFTDDIQAAVCKNNIKIFDDMYDRIFWDDGSWFYEWTRERLSQDLAVNPGNTFTRCGFVSASDNSPTSPALNQTTVGSDSSTSGPSGPPGLPGSITSPSTTPSPALSSASSGSSTGLSGGAIAGIVIGSIIVLGLWAFFIYMWRKRRASQSAPEGPSVGRLFDPQQMVQNTRAGRQEWESLGAGETITRNSNRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK19</accession>
    <name>A0A8H5CK19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000158">
        <property type="protein sequence ID" value="KAF5342744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK19"/>
    <dbReference type="OrthoDB" id="3069255at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="40222" checksum="3DB6EA6BFF8C8522" modified="2022-01-19" version="1">MSSLRSYFTKIRNFFRRRISSARKFFPFFTANKSSPIQDISELQDSGRASDERGPSRLQEGRGNEENVLSRVHEERGHTEAVLGVSQLQADREAVLEASQVQEESDYSEIVFGSRHQEEGEDAETIRTSELQEDRNASIHPDKQLEAPVRKSRSNFGAKTQLNMVKFTIQSLRKLADGAPVPGVGAAFATLLDVINNVQQSRDNEEGLEKLKERFTRLTPIFSHIAEDREEETKLYPIVEGIALEVKSLTDDLHAASKQGKISQFFNNTDNASVLSKHILVLDQIVADSSHSTKMNRNSAVNVTNVTAGDGAEGGSSAIAGGAGGLQGRLSLNHDHSVFYVIYPIGGSGGQGGWGPTAGGAGGAGGGFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKV4</accession>
    <name>A0A8H5CKV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_017056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000147">
        <property type="protein sequence ID" value="KAF5343164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKV4"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748576" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5343164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="17720" checksum="51BDD5CBBE758426" modified="2022-01-19" version="1">MLGLIRLFSFFLIFEGIAAMASPYQNQTEIHHFQAPGEGDVRSPCPFLNTLANHGYVPRSGKNVTIPDIVKGGREGFNVGPNFLSSAGKLGLLTSSNIDSFNLDDLNLRGCLELDSSLTRPDAFFAPNNANLPFNETVYQIMASSNPGVDYYNVTSQAQVQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMG7</accession>
    <name>A0A8H5CMG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000137">
        <property type="protein sequence ID" value="KAF5343606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMG7"/>
    <dbReference type="OrthoDB" id="3256015at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="328"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="587" mass="64469" checksum="CC50A14A1BEF3328" modified="2022-01-19" version="1">MLRDDIQAAKSANHPPVKLDATKKKKRAKPAVGPATAAGPPEVITLERSPPSASDIDTSEPTKHKRQRKGGKGTTTPDVNEASKADPDYVDDSGEVEAVLDDSDEDTPCQVKKAKKKDELRQQIHQKRQDPPMADIVIPSSQPPSKKAKYLVEGFRNVNPKNGIAEPAMKVTSAIEGHSDDLAKHAEGTDNNWEEAKYDAGGFGEDNEDNADEKDMIAKKYQQASSPSKTAGSRYHRFVIVKVEATTSVPEFVSPDKSKTMVVLGDFPSNVRKAFSDYFAPALLEFVGCIKAWTSPESGEMANLWMSCTPDDVHQGWEKLNGPHALLEALANDKITSWRNKFGTTAITVLEEIFRREGVVTAETRQAYVEQQLEGDQKTKNFYFLHTAVVDGKTERAGPFQSEIIARTFAEHLKATKSISYEDRIPDKPVGALVLSILAVQRALTLYSTGEKVMQGAQSHFSQKVRGDKVVNIEGQSKKYKTTSSVHDLFGFNKLMTSTRTGRCPTRIRNNFLARIKMREAAGKEDSSRQVEEAGGDEAGDDDDDEGNDDDDDDDGNDELTESGEKSDEELEDADDAVNGTGNKSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNE0</accession>
    <name>A0A8H5CNE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNE0"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="36519" checksum="322D247594872D38" modified="2022-01-19" version="1">MASSELLAQIQAGKRLKKAETNDRSAPQVDKKSGGGGGGISMGGGGGGGGGGGGGGGGGLAAAMAGGPPQLGGLFAGGMPKLKPAGQNNLAKAPTLGKPPSIPNRQPSPQPPVAPASATPRLPPGRPVPPPASSPSRAVPPPKPAPAAPNRPAPSLPTRAVPKPPPAATSSSERSSGFARPPAPPARATPSIPPRSASPASPISRPPPSIPARPSSAAPARTAPPPPTLPGRAPPPPPPARPTSAGPGTLGKAPPPPPARKPPPVIGSSPASAIRHPPEGTPSPRTSLPPPAAPAPPANPRARVLSAGNIAPPPRPNGAPPRPQRKIPSPPPNAGPHTFPVTDFPPPRPFQPGVRQYTSGRAKGSDFDMDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNK7</accession>
    <name>A0A8H5CNK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000123">
        <property type="protein sequence ID" value="KAF5344544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNK7"/>
    <dbReference type="OrthoDB" id="2844066at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034005425" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="23657" checksum="37389BB019E3D1A4" modified="2022-01-19" version="1">MPYISLKFVAVAIMIASANAFPASHNYPKRKNVERPDVAGLDHCPGRSIGDADRCTFEQQSQLPDRVVWFQFGDAVTNCDSGPDAPDITTKVTSTHTTTETWEHSDGVEFDFFGAKIGGEGGWEESTEKRESQSLEITVPAGKQKVAVVGVNHQQTQGRIRINYGDPSGEPGSNDFHFIYFQNGIVSTQPTDDPPVYDSKEFDCGQPIVIDSNGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNP5</accession>
    <name>A0A8H5CNP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNP5"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="130"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5345045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="289" mass="31649" checksum="21736F62A27C213E" modified="2022-01-19" version="1">MSSTSDPAELKKLVKQLQSLANPKEIVELLGVLKKTFQVNEAVLRESKAGLAIGKLRQHSSKEVADAAKDLVKKWKNEVEKAKQAVGTNTKPAATASKISTPTATSSNGKTEVRSSKTDKPKINVTGDKTRDKCIELLYDALAKDSGAPTDLISQRAIAVESAILNLFGTTTADYKNKIRSLFVNLKDDKNPGLRESVVAGEIPADTLSKMTSNDMASAERKAEDERIKEENLFKSLGAGEQQAETDAFQCGRCKQRKCRYRQAQTRSADEPMTTFVTCTNCGNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP52</accession>
    <name>A0A8H5CP52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP52"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="459"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="767"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5345063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="926" mass="102727" checksum="239719D8360467A2" modified="2022-01-19" version="1">MAANYDKDHMPSPWSPAETSSSLPPRSSVTLPSPWSPIEQPSSSASPPSSSASPAPSSLTLSPYPSLSLSQLSPDLPFDDLPTPKLLSSPTTECECNELTTSCPSPCYSKREYLLAQIRQKDAIIESLLKQLHNPYIATPLSIASYRLATSPSDSGNKNVLAWLDRMQTSVQSQQAAVQDAVKGQASVQGAGGSGGPSAFTLMRQSIANAENKGIGIDGNKNREGEESDDEQQQSPEQSFSGSSPATTKASPANVAGDEDEATADDKLQTLPDSHVPLGLLANLALSNNNKARAAKKEGREREEILAEEENLDDDNVGVANETYFLPGPATDLDIRATIIEQHSPPDILVHGLVTPDDVDKLFDIYYNKCNPFISLLDPVLHTPASTFARCPFLFTVICAISSRYYAEKSEIYPIAMHFAKHSAATALTDGWKSVELCQAYILMSIYSVPARRWEEDRSWLYTGLAIRIATDLNLHHPPATKPQDERQEREMLNRMRVWMICFNLDRSTATQFGKPSTIKENFFIRNSKEWYKKSKYNLAHDVHLCSYSALMRILTCFHEEIFSDPNSPSGLNKKIDFKEVTLKHDRYLTEYHQEWTKRFKEELQHEDESSVFRCKLLPFYVAYSRLVMFSFGFQQAFQRGIQSQDNIFFSKCFEAAKAVVTEMLEGLVPTGYVKYAPDGHFVFSSFASAFLLKLLRPEFSHLLRREDENETFDLIGRVIQTLSSSQIAIDDRHTPKLYARFLAGLLSRHRRDGGAMVGRLQPQPPLQQQVSSSGSFPQSSSMSTFSVSNSQGSSQGQSQGSQLNFQHESYTQQSLGEKVTNSTPVYRPEMSFTAGAGPIQFDNDVTMLNGDGNLSGDDTLLAAMQAVNNPAWWQNMMMPGFSWPDPASPQSNKSSSPPPNSNYQNAPVSINPSYGMFHAQQPTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPP2</accession>
    <name>A0A8H5CPP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IucC family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPP2"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="262"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="432"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69821" checksum="740B954405ED616D" modified="2022-01-19" version="1">MVLLHEPLTPNERAAFAVSSRLLSCFVTESLLPAYYIPVKGQSTACAGLLVILPPGKETSQGNLTIFMLADIFAIVPLHHPPVNKGDDKENIYSRVSLVDPLDMLPQIYGLCPSIVNSEQRDIYGLLSVLESFCDINESIAFEPMNNPLDLWDRFTQSRTNELDETLKRTIRNELMSSWHWQAQSFSAPPKCPSIDSSEIIWEQSLVTGHPIHPMHRTRMLPFNINPEYDWYHPVVRFVRVPRERFDVLGPFHDNIRRLVHSGNESKSMIIPVHELQLSRIISRFPDVEVLPEETNIRADALASIRTVIIPSFPDLSVKLAVGVKISSALRTITHYTANFGPRFSQQIVPKLSITKEVLFIEEEIASAVYRAEDPDEAKHFSAILRKRYIPKPDETVIVCTALWETGHSDVLGGVSAVEHAFELNTTEKRKDFLDRYIRLALEALLPPLIHNGVAFEAHGQNALARFDSKTRQLLGFIVRDFGGVHIHPPTMKSSTEVDFEFLEGHCVVTPCIEEVYDTFYYTVIHSHLQRMIRALGMHYNGIGWEMVRGHLEKLIPPKHELRKLWLDPDSEKSKYIPGKALMKMRMQGLYRDNVYSPFPNLIFYTGEKAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQG9</accession>
    <name>A0A8H5CQG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQG9"/>
    <dbReference type="OrthoDB" id="2681808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="201"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36841" checksum="EE89C504C846DB02" modified="2022-01-19" version="1">MLRFSALIPVHPALQLRWLAIHPPSAPVSHDTILDIGPVLIGTLISYLLMGTLIVQLYTYYMSFPDDRLVVKFTVYSVFVLDLVSTVAITDSAWLILVLGWGRVEGLHIVDWGFTTAPLWSSLSSAIVQVFFGWRVWMLGCKHSINRSEKRLWKTMTALIFAVSMTQVVGAIVSTARFSPINDLAFISIVFPSTATWLSASATADVMISVCMSVLLGRAITRNRRDQVSYITRKTDALLTRIIRNTIETAAITSGAAILELILFLRLPNTGLHAAIARILPKLYANTLLASLNSRASFRRELEEDSVWSLNPIEFRLDHGSVLDPTSPSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR17</accession>
    <name>A0A8H5CR17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_012743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR17"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5346431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29681" checksum="73E7AB120A076D1C" modified="2022-01-19" version="1">MLKHCHVASNPNTEVMPSVKVVIVRGTRGRPDLFAEENRKWKIIMSIAPSSNALASSNALAFRERYEHSRVWWAAECLAEFIGSFLIVYGVVGIGLCRLLGDILPDEELNPYLIKCIMALCACVSGVVFAVSVTLPVSGAQLCPGITLFYVFKRGFHPLKAIMYMVSQILGAYAACLLINSQYHDMINLAEGIVKEAGALPSRSWGNPPTLPGTNVGRVIIVEFLTDFISTLFTFNLFSGSNIISPPLAHPLAGMQSAANAMWALKSEQASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRF2</accession>
    <name>A0A8H5CRF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRF2"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="182"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="38551" checksum="F34C20DF157D1D7B" modified="2022-01-19" version="1">MKVNCNMQTAKFPHFPLNNGTSIPAVGLGCWMGNPGEDSRVYDMVLKAIKNGYRHFDTASCELCQIDNEKQVCQAIRDSGVPRDDIFLTTKLLSDKHDQVLEAFEESLSSLDCGYIDLYLMDWPMAYAPGQQGLWSQEALSVDVWPTFNDAWREMEKLVETGEPRKIHWCIQLFHPEPRNFLPENDLRRYCESKGIQMVAWSPLGQPCPDQPISLLPHPTTKSIASALHVSVGQILLSWSIQRGVVVIPKTENEVRMRDNISLLPLPERFLKEIDGIHKEEGMHRSLSYVHMMSDDREGKVFGWSYKQLGWNMKKGGVVKAGGSQIVLPRKSAQGQEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSG9</accession>
    <name>A0A8H5CSG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_011102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSG9"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034917204" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="393"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5347162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112311" checksum="3C886A7B1F1B5423" modified="2022-01-19" version="1">MWPLSLSLWCLCALSLVQVHAFAYTLLDSPLFQRDHPLINNTGLTDQVGWDKYSFFIRGKRVFIQSGEFHGFRLPSQTLWTDIMQKAKAAGLNTISIYSHWGLINPKAGELDFEGPNALQPLFDAAKEAGLFIIARPGPYINSETTAGGIPGHVLTLPGDTPWNLYNGILRSNQTNYHDAWQDYINAIVSTIADNQITKGGPVIMLQLDNEYYNGPGQNEYIEQLKDAARRLGIVVPTSHNDAGLFQNLLDIPDIYGFDAYPLTLSGCTTPEVWRDLPTNWRSYHEQVTPEIPLLIPEYQGGAFQHRGGQTNEMCRKLTNTNSQRVLNHAMWASGSTGMDFYMFFGGTNWGQIPYPEADTSYEWAAAMFESRELSEKYYELKLQSMFLRSFPDLRMTDLIEEDCTTVPGVTLTFLKNPDTGAEFHFARHTTIGSWDIIKFTREIAGVEVPHLLPGRDSIITTANIPCGGRCKLAYSTASLFSHLTVDGKDVLVAYAFNDTTYEMAFGFNSEPQVKISGANHPEMHFDQKRKHLVISFTEAPGLTAITMTSDGADTILLLADYPTATRLWMPSIAGTGSDHPEYVDISATTPFLVSGPYLVRNATVDGETLSLWGDLNNDTDITLLAPQDVRNVNWNGQALTLSTPTEWGALTASLTGPRATVDLPNLGSLDWRFADSLPEISASFVNSSMTPANHTYTTSKFPSYYGKPWILYADDYGYHAGNLVWRGSFEHGDNMTAPTAVNVSISGGAHFAASVWLNEHYLGPSFIPNSPTNNESFPVSEDMLVDGTNHVTVLQDHMGHNLAGEIVCCTPGGRQRDLQSPKGLQGYFLVGRDEAEQFTGWKVVGNLGGEDFPDKTRKILNEGGLFGERAGWHLPGFDHTQWEKRTPMEGLTKPGVGFFRATFSLNIPDGFDVPLKFVFSSDQGHYRAQLYINGWMMGKRIANLGPQTAFVVQEGILNYRGENTIAVSLWALEDQPEDLRIPSLELVMSGIYSGGVGHASVHSPTWQDLRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSX0</accession>
    <name>A0A8H5CSX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSX0"/>
    <dbReference type="OrthoDB" id="3243659at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF104">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="513"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="656" mass="74790" checksum="2FE991713FD9B194" modified="2022-01-19" version="1">MRLSQRPLISAIGGLWATTGLWIANKQGHWVYLGFLVVKGSFTPNAPPVAATSKRTRVATAKVTDPNNIGDIEVTAHQRARIEAEATNSATNADGTSPGENVEHAKATTKRKTATNSQQPSKKKRSNVMTKSSTEDADTESNQPEAMVIEVSKSEVEEQPKLSPTCDVNHFFEKISVHGDKKPKRKCTGKYRNWAKANGFVSMLPIDTQARRKEMEESQSTLDRHVQPLLPKETVVPYSDELFLEAAIEWLVETNQPVDAIHHPKFQNMIDIAARATNGVKIPGWKATRRAIINLFKKNLTALRKQLLFIREFLYELARKEKDLTKRRKIDRLALTDDEWIQVNTLIDLLAHADKAQQAFSSEHDPTLHNALLALEKLHNAWEKHTSRPKYAAFTNALEAGIEKLEGYYNKTSDSDAYVFSMVLDPRQKMHYFQMNWSEDERKKVTTFTEKIFKERYEQINQTSLTGTQKAKLTKTNSTLLREVSDDEGDEVDMPTQEPVRTTGGVEPWRSEFNLYLSTIDSVPEGVSIVKWWGMRTAMYPTWSSLARDYLAIMGSSVSSERAFSGGGLVITKRRNRLKSDIVEALQFLKCLIKHDLIYWEHATSKTEYAFKVQDVKEELEIIEEREELLKNNTYIEIWHPESDSDNDNEWEDVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU52</accession>
    <name>A0A8H5CU52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU52"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034824810" description="NAD-dependent epimerase/dehydratase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="34522" checksum="8540C9FF67B904BA" modified="2022-01-19" version="1">MRVLVLGASGFIGFPVAQALSRAGYLVYGQTRSEEKANRLAAEEIFPIVCDPSSTSWHHLIPTLDVIIDTLHPSDLNTYLTLFLGIESAAKSLRPASSPKLSFIFTSGTWQFGNQGYDLILTDTTPVLDPTCTGPKAVELAKLDRDRVEQDILKSGILNGIVVRPTFVYGRSASIFSMMFERFRQEGKVSWPGTPGGKLTTIHQDDLADLYVRAAEKAQVIGGLVFIAANNCSEDTDGFLRRFCGIVGVDSKEGPRVGYEYFDPTNIFEKAITTQQIVRPYLARTLLGWEPKKLGLTDGLELYWNAYLASVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWW8</accession>
    <name>A0A8H5CWW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWW8"/>
    <dbReference type="OrthoDB" id="3234349at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125553" checksum="97828766DA42F5ED" modified="2022-01-19" version="1">MNSFNQSVRSALSALSALSALSAPSASSAPSASSASSAPSASSAPSASSALSALSSLSAQSVRSALSALSAITNLLTAVTLSDPGPDVHEQSNKLWTSHNEFQNGIKSNVLPSGSGVSASDIHESMMTTVTNSSPSQPVAPSGVLTSQSPTHSRRASRLSLSLVKQVCNPKLTQMIGKVNSIKDEAIRLCEHLVQLTVQNLDISNEKAVTNCQEAWGKASTRIKQLSVSLLSMQKRKGADYTKAIEEARDELQKVDNVLTLTDCDFIVASVWNIVAAATSIFYPSSPSPSDTPQQQTQQLLLDQLPTSLYTTLNALRLDSKMTTMAVCPSCSFCHKPEFAHTAIKAQYPAQCSQMVVGVDDRSICGASLLQERNGVMRPIKPYAISSLEEHLAHILADPQLEEYCDQAVDDALQEVKNGVLGKPMMLVFDGDFLHGFTGPGDDGTLFIDQGDKAQLALAMQVDFFNPNGNQKRGNSDSIGLVSFAILNLPHEICYKPEHIFLAAIIPGPREPDDEAFLKYLAPIIDMCVIRWKQGMCMSWTANQLRGRTVEWAIALSVNDLPAACKVAGAAGHASGWCTVYNNYHRKYNTSFEKWEKRDVQELRELAEAWRDAECQADQQRIYDSSFMHWSELWRLPYWDPTKMLVVDSMHCILEGLVHYHCHHVLRINAEDTEKKSALVAPAFQHDWIPYDKSKVPEAYWLKDDKIEAQLDQVSEIYDLLESALRSSGECPDTTNLQKCLLGMQLPPLKSVAWSLGVHETTDWDKFAQYNMGRRKAQKVKVIFGGEVVTPKSLKVKSKTSLANALIDWRLSKPLSPMENMADTHMDAAAIKHIQHLISNTSVPTWMNSVPRNYSERSAGSLKADEWRTLATIYLPIALLTLWDWDADRASEHMQKVLHHTMSLFQAVDIICRFGITGELILRHTMTLFPTQTRTHIHIMPTPEFIIRGRLLTWATASSGERDPFSFPWYPATTLSTTMSTDLDKISPKEVAKHTNISPTHTTSQPEVRLHLLTLPSILKKASGSNIKLDSLAHPLWNLYHPDDDASTGTAILITKQDPNQRLLTSTYWESQRLSKRFMPDVTGLTNAVESPVRHMSLSLPSNIINTSNIFPDIEFFFAFEEFIVFALEGSDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXP3</accession>
    <name>A0A8H5CXP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXP3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="13672" checksum="268D34E01A80ED0B" modified="2022-01-19" version="1">MPADAPIYPPLALSTQRSILEVLDFHLEHNPGFPIYTFANDESDQATIISMLEYVRVAHRAGAAIRNTGSARPGEIIAIIAALVDTIVFSAIITGMMKVGFTPFPISFLISPDAVAKSFKRTIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0Q1</accession>
    <name>A0A8H5D0Q1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0Q1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="695"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5351512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117214" checksum="4ED0700DC336CB40" modified="2022-01-19" version="1">MKNYNAFKGRSTFTRPPLDQSLPLALLFDYHGTNSPNHPLFRYDEDGELKTILWKDATAAIRRAAGLVSEYVSQNGDDIPVVAVLSNVDSMTYFATIAGIMRAGYQPFPLSTRNSPAAIAHLVQKKNVHHIFVNTDGPMRDLINTAFQDSELTVNIHDMPTFDALYKSNKIVDLPSLEGVTQDSVAVILHSSGSTAFPKPIALTMRLFMESAMSAYYGEIDVGSQVLSAHAVPMFHLMGVIQIAWTAFLGLTVSVFPPTTPPVIPTPDSVFSAAVKTNSSLLYCVPSFVEALARDPEKVKVLSKFLSVLYAGGPLETTTGDMLFKAGVKIVPLYGQTESGTINHLFPSGPDPLGWQWMRISEHVDPVFVPSDVDHLFKLVLKKCPTHTPAILNAFIDGVPVLDTFDLVTRHPQDPRLFQIYGRADDQIMHSTGEKTNPGPIESILVTDPNIDGAIMFGRSKFYAGVIIAPSPDKVFDPQDTEKLAEYRSLIWPTVDKANDFAPAHSRIFKEMILVTHPDKPFQRTPKGSPKRNAVLKDYAEEIEAAYTAFDESSQTQFDPPKSWNAEDCISFIHVAFQSIMKGDSELGDEDDIFQRGCDSLQVTWIRNTVLHALKFNDQVNIREIPQNFVYAYPTARQLGKYMTNLVQGKALEMADTSSRAQQMKSLVNKYTKDFPKRDQIASSVKADTPGAVLITGTTGYLGSHLLARLLESKEFAKVYALNRPSSTTLVSRQEKSFNGRGLDIALLGSPKLVLLEGDSSKPLLGLQNEVHETLRNELTLIIHNAWRVDFNVSLASLEPHLQGTRNLLDLALTSRREIIPRIVFVSSIAVFNNWHSDKPGPEDYLADPAISVSSGYGESKWCGENILREASLQTPLKPVIVRVGQICGGPNGEWNTTEWFPALVRSSQTLKKLPMLGGHLSWVPIDIAAQVITELSHSNYQFANLVHPHPTTASHILDLVAPMIGAEIVPYAQWIEALNKSQSSASDPARNPALKLLEFFQSQVATADNVNGEVLGLPSLSTARTVESSHTLKTLTQRQLGSEDVEKWIGYWRKIGFLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2I3</accession>
    <name>A0A8H5D2I3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2I3"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034741964" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="46067" checksum="F39965EFA586625A" modified="2022-01-19" version="1">MVHFTTALFLTALVASSANAAPLNKRIAQVIADSTGKWEQACLSAGGGLQCNPVSVAAFTTLLAAAGPCDQQDNADAMIDLAKTLNNDPTMISLAQIFSQQPRNTPTSQSVPYCQKAPKNPELNGLFQCQFQGADPKTFVGGVAVGGEGTIPFGLNAPLNPAGSCKANPDGPIADGTQLVDLTQDPGVKTNSGGSNPSSPSSSATSSPAVHTSASGSKGASASTSTNSPTSSSSSGSSGFKLQNGKDAQALNAQFASLAADSSCNAGENACVDGGFAQCVGDSFVITRCAGGLTCAALPLVNSAGTSITCTTTADAEARIAASGATGGLTGSGATSSTGSSSSSSSSSSSDATTSNSSSGTASSPATNNAASSPSNSGDFKLQNGLDAQGLNEEFASLTADSSCEEGENACVNGGFAQCVGGSFVITKCAAGLTCAALPLVNSPGTSIACTTTADAEARIAASGATGGLTGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D953</accession>
    <name>A0A8H5D953_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D953"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5355464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59424" checksum="1BB5BA35402D2836" modified="2022-01-19" version="1">MLWSWQTTHLPVLMDILTLYPTPALLLGSLSAWLVVVLAYRLFVHPLSRFPGPKLAALTEYYGGYYDLIEDGGLLFQIERLHVKYGPIVRVGPNTLHFSDPQAFADIYTNGTTFAKSSLLYDSFFHSYESSHGYVDLHEARVRRGMLNPFFSRRAILKLRYVIQGKIDRLITRIKEYPKGRPIDLSFAFRSLTMEIITEYCFSASYDALEYPDFRHPLVVVFQELIQNFWLSKYFTTPMRLFASSPTWLLLKMNPGMLDYINMKQDLEDRIDRYIKDESALEAVEHETIFHHLILPRTKDGVIDRSLRPSRRSLVDEAFSLLGAGSDTVGNTSCIATLYALSNPDICRKVKEELRQAWPDPETVPELTVLEQLPYLTAFIKESLRFSHGVVTPLPRVVGPSDTRIGGVLVPAGTVVEMSCVLIHKNPEIFKDPETFNPDRWLTPESKDLETYLVPFSRGPRMCLGINLAWCELYLILGSVFRRLDFELYDTSIEDFKDFKEIFVPVWKGSMKVTVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EZ73</accession>
    <name>A0A8H5EZ73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000484">
        <property type="protein sequence ID" value="KAF5317443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EZ73"/>
    <dbReference type="OrthoDB" id="3022813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5317443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="589" mass="65679" checksum="7DDE6F7BC4D3E1B7" modified="2022-01-19" version="1">MTTLNKSTDSSCLNSSTRRQGSSFVFVVEMTPSQKRSKTTTAVRRSSRVAARQGWRIPLEILLLIMEQLYDSPDVLRTASLVCRAWRGPAQVYLFSQVTLESKEDCKKLLKVLNKSPHIAQNVHRLNLIELGDPSLPTFRLLSRQLKGLLPHSKSPYLGTTLAVDLAEMLGSSILELGTSIYPFGSHIIPFLKPLTRVRTFKLCDCEDMPLESFSEVLKGMTELNSLHLLCGESFADPDKYLDNVEALSRSSSSVESQDVVSSPIRLNTLALDKIEHRFDIIKFLLDSGRFDLENLESLYLAWMEVEDQAEIEFLDFRLVDRLFERVGPSVKDLKFGLTGGTGDNAPDRYLQHLTLDTTNTSLSHLTAVESLTIDCKITSYYGFDPSPYISLLAALPSSTLTTLTIDAYVDVKVFPEHESQYFNEHLADADSDSDPRSNSAPGRAAGSGPNPTSTSVSTWQALDNLLSSSTLFPSLRSVRVIAKIEYDPTMVNYLGFNGDVQGCGSPGCMYCTSTAIMHAQERTGARKNEEGKVRKSCEMLEGWFERALVGLRERGMVKVEVEKVNRCEEFKDMRAYGINFQWDGGAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC20</accession>
    <name>A0A8H5FC20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000327">
        <property type="protein sequence ID" value="KAF5331301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC20"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5331301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="36540" checksum="624E9DC7D6517D30" modified="2022-01-19" version="1">MRAILVKDGKGPIENLYLGEAPEPVLRPGQVMVKIKAFGLNRMDILQREGRYPVPPGASEILGVEFSGTITALSEGVPDFKVGDAVFGLAGGGAYAEYIAVESSLLLPKPPHLSWIEAASIPEVFLTAYQAIVMYCETKKDEHVLIHAAASGVGIAAIQLARTRGARTVTATASTKEKLDWLLSMPNGATHAVNYKAQDFAEETKKITEGHGVDAVVDFVGQSHWKKNIDALARDGRMTMLAMLSGSVVQEVNLADLLYKRLRIQGSTLRSRTVEYQADLVSRFSKEILQNITGPNGKGPIKSYIHKVYSWTKIQEAHRDMEANVNIGKLIVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF29</accession>
    <name>A0A8H5FF29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000267">
        <property type="protein sequence ID" value="KAF5334138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF29"/>
    <dbReference type="OrthoDB" id="1534087at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="230"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="51977" checksum="28789873EAB03667" modified="2022-01-19" version="1">MHLVQATLSPGDCNLAAGPGQFYQGSTYVSRLSVVETRTLDPITLTLLATFSSCKPAPIDMSQRGVSKDRGSDPDHGEHSSGSGKKEKGRRGRGRFAGRMRDSLPRALSALGLGGKRQKDDRPQPDTQGTGSTATSGQNTGTSIHTPKANVSILGQAKDFSMDNSQINVVGGAQYNTQNYFGQQVKTLFMRLFNSDIHFATPPVSGIFTGRDDLVNEGVEVLCREGRKHLAILGPGGIGKTSLALVISDKQEVQAKFQNRYFLPCDILQDQNDLVQGFIQALGLEAQERKSQHEVLFDHLRVLQAPALFILDNFETPWNYKDARTDVSNFIKKLVRFNHVTLTVTMRGIKCPGHPDIQWNRLGAEAGIPTLPIEAAREAFYLISGKSRAGIPEERLDHLLKELDCVPLAIRLVAQLAETIDLENLIRMWDKSKTEILSEPDTEPGKLTSVEYSIELIGIFAKWDPKLEYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI93</accession>
    <name>A0A8H5FI93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000215">
        <property type="protein sequence ID" value="KAF5337557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI93"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034107836" evidence="1">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="235" mass="26269" checksum="A7FA6EFA85CA8826" modified="2022-01-19" version="1">MLHNKVLLLLFFFSSRLFIVFSSAERSSFKISVPPSTDVWRTPITNRFNASTHLLLSSGPVPLKSFNRTRITFSANWTTLFDQGGILLHLTPSKSAKPASTGTSDPGFSDRWLKTGIEFNMDKPFLSTVGTYVYSDWSIVPTSETGGKTTIEVRREVDDTGTSLWVYQLVIGDDGKELQRNPLRQVTWFFAGEDEWLLDVRAMAARPASREDVKGDKNLVVEFEGVEIDVGGVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIL8</accession>
    <name>A0A8H5FIL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000199">
        <property type="protein sequence ID" value="KAF5338159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIL8"/>
    <dbReference type="OrthoDB" id="3252971at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF2">
        <property type="entry name" value="ACYL-COA-DEPENDENT ACYLTRANSFERASE MAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="542" mass="60497" checksum="42BBDD0D3CE114EC" modified="2022-01-19" version="1">MAALTSLLSVESVKIDQARSSIPDLEFATTDGIHYTRRLHGKERLSGVTTDYGEGLGQQMGLADVRLKQVLSREELAAHIKAAWIHLRFSAPWIAYRCKSLNSSEPNSFYFEYKKSSKPDEAEAWADETIVWRTESLSFREWEPMIKQNHWKTGSGHFGVEMHIAKGQEPNQWFFMPSCPHSTTDGKGLFSITDRFLRNFQEELQGGVLLYRNLPWGEEISRLVPNAALIVPNVGANDMLAAPQKPAEPVQFQRFLRKEREVAGPDEISHSIRLSPEQTKAVMVNCKKYRASLTAVVNSILVLAEIETSLQLAADASPDEYARIIESFRTSDVFTLGVNIADMRSHVYPKHAKALGGVTTGGSVNISFPTHHTMNHVRRCVQVGPDGKMTRNLSGHGFWDGLVPETQNGLKVGGRQPPHAYHVAAQMAEAVCPQIKRNPVSNQCVMASSLGSVERLGIFTPFSPLYVSEYPNSLFQIHDWIFGISSTNCPAMVAHTWEYNGRLMIHLQGSSRWQTEKSFKAYAEAVRARAEQISISSARATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FK23</accession>
    <name>A0A8H5FK23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FK23"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034585489" evidence="6">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5339704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="278" mass="29862" checksum="7BCFF083979F95C0" modified="2022-01-19" version="1">MSGPFLLSIIFCISLFPVSFPSLSQTSKHISIPKILFFIGKHFGAGVILSTAFCHLLQDVFENLTSELAKRVYPAAGDDTDDHNRLVRNWNQKQKCRRRCRDPHLARLHPRPRSTPTPFNTHIRDHNTGWELGMILFRGTSGGGGGGADDPSSTGAQALFLLTLDLMCAVSAGMLIYAPTVEMLAGDFVFGSLSGDGMDTDVCMGMDMDIVVGVSGEGYEEEGHGHGHGHGHGHGHGDKAGSVDEDEDERFPAKRAIAVGSLLASVVAMRSIGVFGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLW8</accession>
    <name>A0A8H5FLW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLW8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5341442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29442" checksum="8570CA175777559D" modified="2022-01-19" version="1">MHRVDDYDNFTEDTSEPLTITDADSSSGDVTIFFTVSPGAFRLLAINEDHPLQKPFLMTGPTITAVSKDFESPRSTASRVFPQNTIDNISPADTQTSSSLDTYSTSSSIDTTTTATSSPTPSPMPSSGQPANAQPSDQQPSNSQQSSSSKVPIIVGGVLGGIVFILLLLIFGWVMRRRRRRRTASLHSVIFHRDMMVRQRDYDNLGMGMGSAEGPVGGTQKLEDSRVFRFEGVSTGIGRDGGKPSVRTSPISNYSESVAREDEGKGVHGFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPF4</accession>
    <name>A0A8H5FPF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPF4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="41" mass="4886" checksum="5E0BF769EA9E9D15" modified="2022-01-19" version="1" fragment="single">TGAFAVKIPIEEKLMEDDLSLGLQYRVYKKKVPYRLIPYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQT1</accession>
    <name>A0A8H5FQT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQT1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27153" checksum="16575AFB674AB686" modified="2022-01-19" version="1">MHAHNASSQLFPKIGFGPTVRASGYLVIGCTIVGLCLMRTEYPPKRKDQVPSDIKSFFSDARYMIFMLGALVAQFGVFFPASYIQLYSIQHHVDQNISFYSIAIVNGSSILGRIIGCHFADVYGPLNIQVCFTLATGASIWAVLKIHDTGSLVAISIFYGITSGAWWPLTYNSLASLAQDTSEVGARVGLALALSSFGTLGAPPVQGSLLNETYEWIRPVVFSATMTIGGAFFILIARTLQAKKLNKQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSC1</accession>
    <name>A0A8H5FSC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSC1"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24020" checksum="89BB151ABCB61C29" modified="2022-01-19" version="1">MSAITRNKQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFAQRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDNKAYHEEQAEFYVTDIGDHDIILSTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKTLKPTVIDPRTHHKEYQGDVFKFLFDPSTEIQKKRQSLPKMTTGEIRSQNGGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSC2</accession>
    <name>A0A8H5FSC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSC2"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="496" mass="55278" checksum="3BBCB9DCF583BB74" modified="2022-01-19" version="1">MSFGSEDQFALYPLSNFDVSNIRSVFVTGWLVEGILDHQALRIALTNVTHKWRMLAARLDSAMQEDKSLLWRLKIPLGPLPEDYPTFSLTTSTSDVPLSYYVSEPIPLVSPSLPPSLFIHSNTPRNSYQHVEKDHPLMSFHLTFFHSNNDKTPPRTAIGFTRPHSVLDAYGASKVVTGIIAELNGREWDVPPSLRPGYSPNELQDYLDAEEAKPEMASLLERPLDLQPFAGYTDVGISGAFHALYYHVIKGVWWNEALRHIILLPKKALDYLVNGVRTELASEGIDTPRVSTGDILVAWVYKTIYSTDTSLRKKTHVSSFSAFRDLLPAEPPSLRTHLHNTFITAPYPLFTVASIHSHSLASLAHRMTSSRQLTPSAIKFAHVLSSSRAIRTGKVPGPYHPDADETLSVSNVSYSKMLDNDWGCISSIKDANTLCGYRYVLTATKFPFVNVLFMSGTLPSDGSTVLDVYMTKERMGLLKAEVERVVRLAEIESAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSK4</accession>
    <name>A0A8H5FSK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSK4"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="231" mass="25351" checksum="3EE04D5476EE9042" modified="2022-01-19" version="1">MGWGNGFCGNNNTETLSSLEPDTPCFNTAISGATTGTFVADGYWNISVATIKTEVAKGRRTLVTIQFGHNDQKIAPPESMGKNLTEMVQQIRALKAEPVLVTSLTRRNFFANGTLDDILGPWADETILISQQQKTHLLDLHAASVKYVEEIGEDAAHRLNGTPDDNTHLNKNGTIVFGRWVARVTFNARAVLKFGLRRMVADLLNASFPNQLPIIANPELTFNITHGIPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTF6</accession>
    <name>A0A8H5FTF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTF6"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034447208" description="Hydrophobin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5348028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="109" mass="10781" checksum="E886223D9F4FEB8B" modified="2022-01-19" version="1">MQFKFLTVAALASLAAATPLEVRQAGQCNTGPIQCCNSVQSSNTGLVSGLLGLLGVVLGGVTAQVGVTCTPITVIGGGGNSCTAQPVCCENNSFNGIIAIGCSPININL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW96</accession>
    <name>A0A8H5FW96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW96"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03887">
        <property type="entry name" value="M20_Acy1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="200"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="447" mass="48826" checksum="41B3F21EF53B8FC5" modified="2022-01-19" version="1">MNSTQTQVWRPEDDTRPTAECPEGLPIFRPDILDFIEQKTQGLSGELRKLSMDLHSNPELAFEEKHAHDVLTEFMSTQGFQVESHYLLPTAWLATFRHGERGRTVGINSEMDALPGVGHACGHNLIAIAGVAVACAMKAALERFDISGTVKLLGTPAEEAAVGKIILLQKGAYDNMDICLMCHPAPGPKGSVSLSSSLAIKGFEAEYFGHTAHAALSPWEGVNALDAAVLAYNNVNALRQHLKPDIRVHGIFKGKDWVTNIIPDYAMYHVAVRAPTLARQEAAAERSVFRSGALATGCTSKITSTVHMYDLRQNKVLGEEVANIVRSRYGTVDYEWGIASASTDFGNVSYEIPSLHPGFGGRTFFSFFVMGAHSRCFHLSAIPTIIGGGNHTREFATAAATMAAHEACLDVSKALAVTGVRYLIDVDFHDRVQREFERDKVAREMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYB4</accession>
    <name>A0A8H5FYB4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYB4"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="90"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5353681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="466" mass="51988" checksum="3E770A8B2AD707FE" modified="2022-01-19" version="1">MNSGNYPSTTSFDSSIPAGAVSTSSELDRPTLGECHFVSDLTILEDFYECNDTAMRYFVGATSDSATSDSLTLEGNGASHVNLIGQPNVTVSLTKPVQNILKKRPFRWFNHPKHLDSIISACLSAAPVPASGIGESEYLAKENVVITWRGILTKIFLGDTITMHASLIDGRLYMEEEDPKPNWKAKKYSLSDAVGKAFEDTFTETRPIGRDGLPRRIPKANTQWCNVVSRTLGDLNLIFGGEVDAFNCKASEDLHDNHGILDRRVELKTKLLGSKIHYPRWHMQSHLLAVPQIFVGYRNDNLDIVKTQSIHTANIRPRNFEENIAKGYRVLSVLRGHLSRSAELERCTRLQSSTSASSESHTNLDSPDLGLDKLCLKDPAIDTTWDTNTGTGASDDASDCIWKVTIRKWTIDSVHLLSMADAQRVKERRENPSKPVERLGIVPKVLIDAMHTKYKLRSANRVLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYF7</accession>
    <name>A0A8H5FYF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYF7"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="529" mass="58212" checksum="181FC75CD0950574" modified="2022-01-19" version="1">MGWFIPLLLVLLVLLGLYIWSNDRALRSIPKRALEVSPTRLTPEDVLVTAKRLSSSRPMSVDDQIPPKTGRRYIVIGGAGFLGGWIVIQLLKRGENPKNIRVLDIRPPSRMDLKEGKAKDVDFMKVDISDAQAVQKAFDAPWPSDASSISPVTVFHTAANIRFYERAIHFVPRSARVNISGTQNILNSARSIGVSTLVYTSSGSIGIFSSRYLLWPWQREPEHFVHFINDEDSRLPKCHADFFSNYAYTKMQAETLVRKADRSSSGNGVLRTGCIRPGNGIFGPGGDMLCGAYLVRQTNPTWIGNIVSHYVYVENGALAHLLYERRLIDLEAPTSGTDGSKCPDIGGQAFTIADPGPPPTNGDVYTILATLTDGETHFPSLSPTFMLLLAYLIEAYYITREFILSFIPKIGTLIPPINGDLVNLQPSLWNLVMTHLIFDDSRARLPPEKGGLGYRGAWTTEEGLHKTVQEHYARADPSHRSGSAGVSFGFGLVRAQRGVGKVGDKVKRRTGVNPIEVLGSEAANGSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYP0</accession>
    <name>A0A8H5FYP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin protein dnm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYP0"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="752"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5354565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="91694" checksum="1D3FB8501C498F05" modified="2022-01-19" version="1">MDSELIKLVNKLQDTFNNLGGELDMPQLVVVGSQSAGKSSVLETIVGKDFLPRGQGIVTRRPLVLQLIHTPVPAEPSPTAPPYTEWAQFLHLDKRFTDFAEIRKEIEQETFRVAGQNKGISKLPISLRIFSPNVLDLTLVDLPGLTKIPVGDQPSDIERQIRNLVIDYISKPNSVILAVSPANVDLANSESLKLARSVDPQGRRTIGVLTKLDLMDAGTNAFDILTGRVYPLKLGFIGIVNRSQQDINSEKSMDDALNDETEFFKNHPAYRNIAHKNGTKYLAKTLNQVLMNHIREKLPDMKARLNTLMGQAKQELNSFGDAAIFGDKNQQGALILRLMTQFARDFVSSVEGTNVEISTKELYGGARIYYIFNDVFGNALMSLSATQNLDNQDIRTAIRNSTGPRPSLFVPEIAFDLLVKPQIKLLEAPSLRCVELVYEELVKICHNCTSTELQRFPHLHAQLIEAVSELLRERLGPTSEYTQSLIDIQAAYINTNHPAFIQGSALASAQANPPPKSQAIPPRPSSAASVQPNGLDDEDEDDPSDDDSSINGFTSRNDSRSVSNTIHDRSRVSTASAASTPTLNNSSGSKRSSSRHPSQPQRPRSAIGTTGAGANMAGTGGPSGSSPHSAKETFLNYFFGQNGPGPIAGGFDAGVVGGHGHGHGAGGGRRHGSGGRDSLGVDVGIVPVGRDMTGPDPVLSSGPMAAGGNAAYDMKSLGRHIEAWSLRSFRFISFRHIPADGGRLTVREEMETNLIRSLITSYFAIVRQTIQDLVPKAIMHLLVNHTSQHVQNRLVASLYKPELFAELLNEDETLVAERDRVKALLDAYKDAFKILSDVSVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1N8</accession>
    <name>A0A8H5G1N8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1N8"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="259"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="590"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5356710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85656" checksum="EAA162A832AECB45" modified="2022-01-19" version="1">MTSSGKIPDHSIRICADRGGTFCDVHASYPDPENPDGERKEMVVKLLSQDPANYKDAPIEGIRRVLESVTGEKIPRGQVLKTDKLEYIRLSTTVATNALLERKGTKHALLITKGFKDLLLINNQSRPRIFDLNIRRPAVLYDTVVEIDERVTLVGYTSDPRAEEHRVIFDEEGKVDKGYTGNGWDGVEGHYGEGPGEVVRGISGEALYTSGYRSLAIIFAHSYTYPHHEQLVGSLARQIGFEHVSESAQLIPMIKMVTRGVSATADAYLTPILRRYLDGFFGGFDQQLRDGRVKIPRVEFMASDGGLVDAERFSGLKSILSGPAGGVVGYALTSWDEKEGRAIIGLDVGGTSTDVSRYAGRYELVYETTTAGVTIQSPQMDINTVAAGGGSCLTFVNGLFRAGPESAGAEPGPACYRKGGPLALTDANLLLGRLIPDFFPKIFGKSEKEPLDEEASRKAFEGVVKRVNEEYKKPSSTPKSNQNQDKEWTFDQVVYGFIKVANETMARPIRALTEARGHATGKHVLASFGGAGGQHACEIAELLGIRLILIHRYSSILSAYGLALADRAFEKQEPSSLFYNSSTYPKIISRLDKLEKDVTEELAKQGFEGKKVTTERMLNMRFEGTDTSLMVVVEEGEKTEAGEDFMKAFRRTYKNEFGFLLEGKTVVVDDIKVRGIGKTFDTLGDSVYTELDRLASAKSLRPVSKAKVALTHPVYFDIIGRVPDTPVYRLEDLEIGEVVKGPGMVLDDTQTIVIVPGWRGVSCSRWVVLEKDEDDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3G7</accession>
    <name>A0A8H5G3G7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3G7"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5357583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="107" mass="11216" checksum="29F8F9E14934161A" modified="2022-01-19" version="1">MAAQATFKSIKAVVPLLDRVLVQRFKPQTKTAAGIFLPTSATSTPLPEATVIAVGPGAPNKAGQVVPTSVKAGDRVLLPGWGGSSIKVGDEEYQLFKDSEILAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5K0</accession>
    <name>A0A8H5G5K0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5K0"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5358665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="451" mass="49874" checksum="C3DD1939BAC66400" modified="2022-01-19" version="1">MTGTVDGLTRRKLSRTIRIMRSSVLNALGIVFSIGSTDIGPSAGAQTRLRLHRDYPERISLISAAPTRLSARRLHSTNPGVSPSWAMGVEFSHPEGQAIAREVKKDVPGRSHGCGVGHSVLLSHASAVQLYRSSFKPTQKGQIGITLNGDWQMPWDQSPENVEAAQRALDVAIGWFADPVYLGSYPSYLRQMLGDRLPEFTPEERKLVHGSSDFYGMNTYTTNLCRAGGDDEFQGLVDYTFTRPDGTQLGTQAHCAWLQDYPQGFRALLNYLYNRYHTPIYVTENGFAVKDENAMPREHALKDTDRVNYFKGTTQALLDAITEDGVDIRAYFPWSLLDNFEWADGYVTRFGLTYVDYETQKRYPKESAWFLVNWFKGHLYVAPPTPPPPAINRDSSSTSSVTVAKKSGSTTPDTKAGDSGASSTAIIQEQPKVGVLGKVKAFLVSLVRCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G641</accession>
    <name>A0A8H5G641_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G641"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="31"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5359027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="486" mass="53403" checksum="31F2BDDFAB433464" modified="2022-01-19" version="1">MIQVNNSVRRPAPPLPAVETNGPEVWGQWCGRKHYSLEVTQHPIRARMCGFGDKDRRPLAPAAVAKMIVRRDDNSLVDVDDIDCSFFLVTVDLWSADGKSEMNLVLHPSSADRYIPPHVVKPRRRGASISAPQQRSGYQTPASRTTPTPSHYRDTPIQTPMLPTQPPGFSSNQGYFGPQPSISDLSYGSSTPFSATPSNSGHPTWGIPAQSQSTDRNTAFPPPALPSIQSFGRTSTSNMNQTSNDPWHPTSQGGDLSYRPWNTTESSYPGLDFGNFQFSSSKNLNRLISVHYEASDTFASPQIPPQYDNSVYNTPGQPYNTATPYYASSINQSQSNQNPPPPPAVPIHIPRHTYTRTLVGPLSANATRLLDEHRKPGIFFLFQDLSVRTEGTFRLRMRLMNVGAPPAPEAGALSIHTNVSPVLAQTFTEPFTVFSAKRFPGVPDTTALSIAFGNQGQKLPLRNRNGSSSGKRRRRGDSDDDDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8R9</accession>
    <name>A0A8H5G8R9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8R9"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5360310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="79656" checksum="0A8C715773077A71" modified="2022-01-19" version="1">MTAPRSPNSSRSKDEHDVPVENAVIEDSPFLLQEYRLYRRRYVGLFGMVAFNIVGGMSLPWFGPIANDAASEMGWTLEQITWLGNIQAGLYLPAALVIPRLYIWLGLRKLSYVGSILFIIASWVRYSGTVDSLTNNVSFGLVILGQVFASFAQPIYQVLGPKYSENWFDLKGRTTATMIIAVANPVGGAIGQLLSPLVGDTKTSILVLGIIGTAIAPFTFLIDTHPPTPPTFTASKESPPFTHLLLDIVGKAPDSHMSSNRARIDFVIISLLFGTLVGVTNTFSILTNQIMEPVGYDKDTSGLMGATLLLTGLVAAVITAPLFDRVFTRHLAFTSKLLVPILGAAWLSLIWAVTPNNTAALFVIMTIIGVSALTMLPIALELGCDLTQNAEGSSSILWAMGNLMGFIFVLVENHLRAGPDAHPPNNMKQSLIFQGSFVMAVVLLVFFIEGKQTRKDLDEQHARPSGAMESFVGGFGRNGAGLERRVLDDDLEQSWKISCSARTSRRPEECSFFPFDAPKKAKAPREEATVSLGPQVSEGELVFGVAHIFASFNDTFVHVTDLSGKETVSRVTGGMKVKADRDESSPYAAMLAAQDVATRCREVGITALHIKLRATGGTGTKTPGPGAQSALRALARAGMKIGRIEDVTPVPTDCTRRKVVTVFIMRRRSYVPVRPRKTQTSKATRTNATPLDAAYEYLHNTPIPTRLDAKTHPSPELETVLMHLKTLMDHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAE7</accession>
    <name>A0A8H5GAE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAE7"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="21293" checksum="07D56CD599C0B71B" modified="2022-01-19" version="1">MFELLDRTQPHSVQFHAEHYSLAYREEEEREMFPTLKHFGVGSIPWSPLARGTLTRPLSQQTKRSETDRLIKNYKGGDIVNRSYNKPISNTHSVEELAKKRGISMAQVSLAWVMNRPGVTAPIIGTTSLDNLKQLLGEWNLVYVALLRPFNFDHGNTAAEAIDIILTDEEMKYLEEPYQPQGIIGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDE3</accession>
    <name>A0A8H5GDE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDE3"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5362700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="478" mass="52701" checksum="8D97CACA51F0D9BF" modified="2022-01-19" version="1">MTQNSRPSTLQSFQGDLVYPNDPSYPSAIARWASNAERQAALVSFPKTTSDISLVLDYALHQSKPPLPIAVKCGGHSASGASSSEGGVVIDLSRYFSEVRVDPEAKLAYVGGGAIWATVDEKTAEYGLATVAGVVNHTGVGGLTLGGGFGYLTGEHGLVIDNLVQATITLQTGQTLTLSSKSDESPDLFWGIRGAGSNFGVVSEFVFRLNPQRKDVYAGVMVFPIDRVEEVCQVANAWWDNGPSEKERLFINLVWNEDMSEVVLQVAPFYNGSEADGRQVFNAFLELNPTQDLTTSLPYIKLNAALNDQFPHGRPYIPTGFQTHRAQANPESIRNAAKLYKRHQEQDSKLARPIKLNVSVIHEYTPWAKVSSIPDSEGGPFPRNRVNNGLLMATWAENEKEINLKAREMVNEIRNAFLDGKTNQKSEGPKTIEKDFRQSPASRLEGLYGVENYQRLKTLKKTYDPKNVFCSWLPIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGN9</accession>
    <name>A0A8H5GGN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGN9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000004">
        <property type="entry name" value="EmrB/QacA family drug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5364440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="572" mass="62033" checksum="9AD5247DF6619FA4" modified="2022-01-19" version="1">MSHTGENGSAPSLVPDSIELPTTANSSTSDLEKGKAKQHWSEAEVHEIPHKQVSAYSYCEIPTDFSLIVFLGALDQTIAAVALPTIVDDIGGESGYSWIGSAYLLMSACLSPLYGKLSDILGRKPVLFASIFVFLFGSAMCGAAKSFIWLAICRGVQGMGGGGIMQIAMIIASDITTLEERGKYGGLMGLTWGFASVAGPLIGGVLSDHVSWRWCFWINLPTGAVATFLLLFLRLNPVKRPSFVEAARKFDWVGLILFIGGVVLVLIGFQEAQLLDDGWSAPQTLAPLIIGLACFVVGGVNEWYHPFTTEDNCVVPPRLFRTRTTAAILATGFLHSLVFFAASYYIPLYFQILGHSATGAGVRQLTYTLGWCLATIVSGVILTKTGKYKWMMRAAWAIMLIGYGLMTLLDESSSDARKEIFILITGFGVGTYFQPPLIAIQAAMPLKDMATSTAAFMLLRMMGGTIGISIGDTVFSSEFVRRIKSVPEYAMGDRTQILRDLGKLKNIQPESLRKEVLHVYTKSLSTVWIVAIAFTAFGACIVLLIREYSLKRNVNHSDSQKPDTSLGAAMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGP8</accession>
    <name>A0A8H5GGP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGP8"/>
    <dbReference type="OrthoDB" id="3052647at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="473" mass="51382" checksum="DF31C22FC31371E6" modified="2022-01-19" version="1">MSTVKIIVDDSDPRIQYSGSWTITSGNINQRNQQSRTGAVYNNTLHSSTKNGTSLSFRFNGTGWLGVYGTYDTTNSPGIEPPTCFLDGNFTWTFSTLTPGKLPTQLANNKLLCRADSRIGAADALPGEHELQVIHTDPQTALLFDYIVYESVPDSATDGEVLQISNQEVWDEDSNITFDAGWADNVDDSVISTEVNSSATVRFNGTGIQLLGTVLTNSSEATAGSYAIDNQQPVSFQYPFVNNSLPDSVFTTKKDQFTKQLLFNLSSLSPGEHTLVIINQAPNGTALDISYLFAQSLTKEEQASLFIPSTSPTSLAIPSPTSISSPLPPATSQSPKGHAGIIAGATLGFFVLIAFISGGIVLWQRRRLRRATGMTPFTAYTVSRSQQIITRADLKRAKAQGKEGDQDEGTEKAPLPSGSTSQEPNDMRVTNMKLQQRLAIMQDQVDQRGRELAERPAPRNEPMIEVPPNYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH94</accession>
    <name>A0A8H5GH94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH94"/>
    <dbReference type="OrthoDB" id="2996139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="309" mass="34443" checksum="32BEF2D1AF1576A9" modified="2022-01-19" version="1">MGSEQSNYNLGNNVDANANTSSANTSTSTFIPPRMTHTGPRATVVDSSSGTSIDPTSGMSSSYSYVLMPMPLPGSADAPSFDGTEVSTFVDFLEQLARNAGILDLNDIIPYVLRYSTVEVRDAIRYEDPFVKGNDEYNWASAKETLLSIYSEYDTKPNVTHQDLLDFCRHHNEQGAIESSKDIDKYRIAFQKFANGLVVDGVIGKQQRNYYFIAGLPKVVKEWFIEALPESQRMPETAPTVNDSVSLLKTRFGPKNLYTTPWASSSQSYKNQVRLDLDGNRIPPSHGLNFRLILQLSYPAFMVEEALEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI16</accession>
    <name>A0A8H5GI16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_005367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI16"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60184" checksum="F95A4C0BD397EEEB" modified="2022-01-19" version="1">MSIHVSLNSMAPALVGLVVTLLLHKIWRVRSEQVQLAAIPTIGPQGFFGSYIGAIQFMSRGREMVEEGYYKYPEGAFKIPLINGWVIYVNGKKMAEDIKKASTNELNFVEAVGERLKLDYTMGKGIRVLPYHAEVVRTTLTRSIAARFPDIRDEIVHAFNNVVPATEDWTSVHALPSIMKIVTRTTNRFLVGLPLCREPEWIDLNMNYTIKVFLSAQCIDLFPTFLHPIIARMVTPLPSAMRRSMKYLVPMIEERLAKEKEYGNEDWPDKPNDLLSWLLEDTPGPEQRTMEELTHRVLAVNLAAIHTTSMAFTNTLYHLAAAKPDVVQTLREEIEEAVNEMGWTKLTMGRLWKLDSFLQETQRTNGTGASEIVSPMSSSPLFVCAHLNPIYIAVMSRKVMKDFIFSDGTFVPAGSIIAYPGYSTHHDESLYKNATTMDPFRFSKMREQNGESIRHQMVTTREEWVLFGTGKTACPGRFFAVNELKALLSHVLLTYDVKLEQEGELPQDEWYADACVPNKSAHVLFRRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIL3</accession>
    <name>A0A8H5GIL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIL3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5365471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58084" checksum="E379EA3420CAA4BA" modified="2022-01-19" version="1">MPIIDTDEKIQSSGSLHELEAGTNRKERDQSLEDSTNVSTLTESEERRLWTKIDLRILPIVSLMYLMSFMDRGNIGNARLQGLESQLHLEGNQYNIALTLFFVAYCVFPYAYEVQTVNDRWLPGLTVLWGIVMTLMGLVKNYPQLVATRVLLGVSEAGLFPGVTYCLTLWYPRHSLQVRIALFHGAASLAGAFSGLLAFGISFMDGTQGLLGWSWIFIIEGIATVAVGLLAFWLVVDLPETAKFLTPEERAFVITKRSTSLRSLAYCVNLRTNSLSVEMDISFVGEEEHFEMKHIIQALTDWKLWIQFPTYFGVLVPLYGITLFLPTIINAFGERSTAITQLLTVPPYIFGTILIMLFAHLSDKLKIRSPFILLSLVLCLIEFSINISDTSSGVKYFGTFFIVGGAYAGVPGLSAWFGNNVSGRYRRAVGLALQVGVGNFSGVIASNIYRTQDSPRFVLGHGLELMFVGMGLILLPIMTFIYARINRKRDALEERGGGRVFTHEELRALGDRAPNFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIY4</accession>
    <name>A0A8H5GIY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIY4"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="608" mass="66464" checksum="4EA16AE7C4E75F69" modified="2022-01-19" version="1">MSADEVFEGAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFSAEERLIGDAAKNQAAMNPKNTVFDAKRLIGRRFDDPDVKKDMTHWPFEVVEKDGSPLIKVNYLGEEKTFTPQEISSMVLTKMKDISEAKLGTTVKKAVVTVPAYFNDSQRLATKDAGAIAGLDVLRIINEPTAAAIAYGLDRQSKTEKNVLIFDLGGGTFDVSLLNINSGVFAVKATAGDTHLGGEDFDNTLLEHFKNEFKRKSKLDISDDPRALRRLRSACERAKRTLSSVTQTTVEGEDFSANITRARFEEINAAMFKSTLEPVEKVLKDAKMAREKVDDIVLVGGSTRIPKIQSLVSEYFGGRQLNKSINPDEAVAYGAAVQAAVLTGQTSEQTKDLLLLDVAPLSLGVAMQGDVFGVVVPRNTPIPTNKSRTFTTVEDNQTTVTFPVYEGERTQCRDNRLLGEFELTGIPPMPRGQAELVTTFEVDANGLLKVSAQDRASGRKASISITNSVGRLSSAEIDQMIKDAEQFKMADKEFSARHEAKSDLEAYIHQVEGTITSPEIGMKLKRGAKAQVEAELARALEKLEIEDSSADELRKAQLGIKRALQKATAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK94</accession>
    <name>A0A8H5GK94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK94"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="239" mass="26169" checksum="0089968A0E35B1E1" modified="2022-01-19" version="1">MPRSSSHSPAHTKIRPAKCSNSLPPRFANELNFNTLHNAAAAIAGSVKPETHCRQQQAVTEFAIWANDMGLHPDEVLPAPEAVLCEFAASFLGRLAGGTVKAKLSALKAWHTMLGFRWLRSDLLHKTLTGVDRQSPSSLHHPERPPVTRDMMRSLHAAWSTSNHGDHKCALSGSKCSLLGQLQLVWILETNSCGGQVLAARQRHSATVMMVEVEGLKWNNVEVSINSDLTTMKELWASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKW7</accession>
    <name>A0A8H5GKW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKW7"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="429" mass="47032" checksum="6C543874E190BE00" modified="2022-01-19" version="1">MHLAQLYASTNWSSFFPLQDLWLLTSTMASARATPEDVELADIPTDSVSSLAFSGKADYLAVGSWDNSVRIYEVSCSQGQRIHSQGRAMYNHNGPVLTVCWNEDGTQIFSGSTDTTARIYDIASGQSMQIAQHTEPVKTVKYFVHPQSHSGILVTGSWDKTLKYWDPRAPTGQPIYSVTLPDNVHDFDVKYPYLVVGTSSNPNDVSANPIHVFHLDNPTVPYKSLVPPMKKQLRALACFTGLRGTPSGSRNVLGAGGTDSGPGYIEDRDASKSYSFKCHRQDTATNSKDQALIYAVNDVAFHPQTKILATCGSDGVYSYWNLETRTRVKTSFTSGLSTNVANPTSTPFAPSSPFNVNTVNRNAYSTNSNSTVLNPPITSIAFNASGNVFAYAVSYDWHKGYIGNTPGYPNKVFLKRVTDEDLTARSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM24</accession>
    <name>A0A8H5GM24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM24"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="21465" checksum="53310D8880A3755F" modified="2022-01-19" version="1">MRQFNVVVLGAGGVGKSALTGTVSSVRFIRDIFVENYDPTIEEEYRRTVNVDGELSSLEVLDTAGAEQFTTLNEVYIKAGKGFVLVFRQVSSAEVDHLRKQIYRIKGGDAQTIPIVVVGTKLDLVNEREVHRNTIQSLASRWNLPFYETSAKRNWHVSEVFEDLLRQMRSRYPKETPKNPKTGKRCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMN4</accession>
    <name>A0A8H5GMN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMN4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="585" mass="63603" checksum="BEE1D35288BF2139" modified="2022-01-19" version="1">MSPTALYPPLPNPAAATHGQTVTDPNAPSSPGVAKTQYPAKAPGERVDLPTPSQPRETEFDYLVVGGGTSGSVIAARLSEDPNISVAVIEGGPSDVGLDSVLNLKNWINLLGGELDYDYPTVEQPRGNSHIRHSRARVLGGCSSHNTLISFRPFPQDLDSWASIHGAGKGWSSHTIQPYGSRLLLRTAPVHPKDRNATAKAWVESSSKALGVPVIQDFNAAIAYHGGLPDGGVGFFPVSYDPNGFERSSASVAYLHPIMKKREENLKFFFETWAYGLEFSDEGGDATKVVGVKVKIGNGSTSGGGEDKVLRARKEVILCAGAFDSPKLLMLSGIGPKAELEKLGIKSRVNLPGVGENMQDHPESIIMWRAKSSPKETVMTSDAGLFVRLDKSSEDPRPNLMYHIYQIPFTDNTERYGYEKPEHAVCMTPNIPRSLARGKVSLASSNPFDKPLLDFRYFTDPSGYDSSILVQGIKLARQIAQTPPFSNHILDEIAPGPNVRTDEQLDEYARKVHHTVYHPSCTTKIGADDDPMAVCDKRCRVRGTKGLRVVDAGVFPTLTTVNPMITILMVAERASDLIKEDLYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP22</accession>
    <name>A0A8H5GP22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP22"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="811"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="902"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1246" mass="135916" checksum="FE49BD984B0EC6F4" modified="2022-01-19" version="1">MCVLPKIVSTRIFCKGSEISTLHAVLGPDAQSSCVFSLNRTRNGLGEDGLVNDDHDVNLELEFFSSELRLRGNLPVVQPHQKDGNVLCWNGEIFCGLDVSAEENDGIKLFDNLCTLDTPEQVPGLFASIEGPYAFVFYQSATQKLYFARDPLGRRSLLIHKPSPECPYFLLASVSAGNDPGYDFEEVSTENVHVVDVSRLRESQDGRPHRLNQTLPDDDAPQATSLDTIPDWLQPSVDELISHLDRSVMLRVRDIPRHTIKAGESRVAVLFSGGIDSTVITLLAHRHIPIDEPIDLLNVAFENPRKIRVQSEGNLGGVPKKKQKLNLKKQAAQNANADATPLRDMYLVPDRKTGLQEVEELRRLCPGRIWNFESQAARRHVENLMSPGRTVMDLSLALALYFAARAIGQIRPQAGAEPVPYTSPTRVLLNGLGSDELLGGYGRHRSAYNTGGWQAVIEELQLEIDRIPVRNLGRDDRVISSHGKETRHPFLSLDVVAFLAELPVHIKMDPRLDVGLGDKMLLRLAARKVGLIEASGRKKRAMQFGSHSARMEETDTKGDLLASLYDVPGGYQAVMFDRFSGVKDKNISTTTGSKDLQMVSITLRVMSRPDIEHLSTIYQTLGMDYDERVLPSIGNEVLKSIVAQFDAAELITQREVVSARIRADLLQRAGEFNILLEDVSITHLTFGKEFTQAVEAKQIAQQDAERARFIVEKAEQEKRAAIIRAEGEAEAAKTISHALEKAGEAFIALRKIEASKAIATSLANNPNVTYIPTGGGNVLLNVPTNKSRLFYSSSIMNPMGMGGPAEAPRRAHLYVGNLSPRVTEYMLTEIFAVAGPVQHVKIIPDRNYQHGGLNYGFVEYMDMRAAETALQTLNGRKIFDTEIRVNWAYQGQQNKEDTTGHYHVFVGDLSPEVNDDVLAKAFSAFGTMSDARVMWDMNSGKSRGYGFLAFRDKTDAEQAIATMNGEWLGSRAIRVNWANQKTQGSPAIAAAAPRPGPGGAGGAPAPINFQGGPLSYESVVQQTPAYNTTVYVGNLVPYCTQADLIPLFQSIGYLSEIRMQSDRGFAFVKLDTHEHAAMAIVQLQGQMVHGRPIKCSWGKDRAEGGAAATPISPTAGSPYGNMPMYGMPQPNTFGQYGFGGYGGYPNQAGAAGAAGATGMPQPATGAAGLGITAGAQQPGADPNAAVGQATQAQWAGADPSSYYSNYWGGYYGQQAQQAGGDTQMQARFSFVCSVTASTHFYRSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP34</accession>
    <name>A0A8H5GP34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP34"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="81" mass="9421" checksum="E520CD461E0668EE" modified="2022-01-19" version="1">MADNFDEATKKELSAFLEKEQTQAKLHSTVHNLTTMCWDKCVTSTPSTRFSRGEESCLMNCVDRFLDTSIFLVRQIQERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP86</accession>
    <name>A0A8H5GP86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP86"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223031" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="35762" checksum="4965B4B58D3A4F34" modified="2022-01-19" version="1">MRTVTFLSFLSVVLAHGGHEASGPAKGETIQQYARRHMAKEHHIDSFDLRSFFQLHDLNRDGFWDREEIEAIYGVHHVYSQKKSKDDEEHQKKADHIVGEVLRILDGNKDGKVTPEEFEAVGLDGLPNFDHMGAEGHHYDVESEFFLHHEEEYHSTPETQTDESYVHPEDIEHFAQHEKIERQEAEKEAAYQGISVEEVLKAYEEAERAAEQAAQDGSGSQQQPMGDAEHPHAEQVEGQEPPSESASAPNVRVTRVTPPEKQDPAVRFRNAKAEAEAKGAWGVGEDGYAPPVNPGDRMRKNLPYKYKFRRSWGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPP5</accession>
    <name>A0A8H5GPP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPP5"/>
    <dbReference type="OrthoDB" id="5564877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="1">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22262" checksum="8D972862930761C1" modified="2022-01-19" version="1">MPLVVSNTVARSPEDVETLSQGLFVAETILQQAVDLIDAHLTSDDQLTVHSQHLPGSTIGKHLRHSRDHYEVLLECISSPAPHILNYDARPRKTPMETNIAAARDGLLQTIRKLREQVPKAEWNAPITVHAVTPFIQSFETTFGRELWFASLHCIHHWSMIRVIAGEMNVVLPNHFSFAPSTLVHHGRLEASPLGRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPW4</accession>
    <name>A0A8H5GPW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPW4"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="225" mass="24869" checksum="235F621CD79F4E27" modified="2022-01-19" version="1">MTCNAGASLQLFGPKQFGAAGPSGRLDIKTFRYGTIEDIKKLGTFNEWTGKLLKIPGVPPMYDYELVPQDIAIFNSASMLEETARIYIPECDGMFSISASALDGEDMAVLNTWFDSMGHVHYAIGPLTVPKTGEYVVGREQGKEAAHVTVVKFLKEMQAKHGKKSVIYISFGSALWLINQDKFWVIVEEFLKNDIPLIVAHPAALGEVAASKEDLNQEIVLLQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQW3</accession>
    <name>A0A8H5GQW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQW3"/>
    <dbReference type="OrthoDB" id="4151615at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="455" mass="52080" checksum="BF7C67A300A1FE86" modified="2022-01-19" version="1">MTTPMIPTDDQILLSLLEIRKSTPGLGRAKILSRLKSENQWTLSDARLKKMIHILTAREDSLYRESRTQINELIFAALDPEHNGTGSSDSGEDASHAAGNLSPSSSLRKQPTDMQLLAALEEIREMEAENVPRAKILARVRTEHGWDLSDKRLKRWMKECYGHAEFLEPGPSLEPGLDLDDYGPEFDLDSENEFGSYQGSSDSDDRAGPGSVDEEDDSNSAEKSPMEAQDIYMTLVDSVLDMQGLSSLPESHRPRIPEYLDQEDKDESGLPLPDLPQDAFDAQMVYMTRDKDRGIILYGRGRFDYFFMPEPTMRTFFSDVLENFAPYHTFGPPKSPERKLKLAEKGWFMTLWELYEVGAQKAGISRADVGRQFEAEFGVNMHHYTPSRQQYADDQTKEILQTWEKERAMKWMAIKSTLMLQLGIDKQWDETRDGQFAIQRLRKIDRETGEEWNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQZ5</accession>
    <name>A0A8H5GQZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1729"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1806"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1732"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1825"/>
            <end position="1834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5369280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1853" mass="207180" checksum="8840A231F7373F0E" modified="2022-01-19" version="1">MPQTPEAQAFIHRITSLPKDPGVSLHEVLQPSIDDEAELRRLWATDKLNARLQNPYVGLVDVFDAPVDIRTTRARIVPEKNSNDVSSGDEDSKYVMPLADAERRKEGEPCMVTDLEEFKKNWSVFSEGSLSQLMDWNNVIAAGGSVLACLTPLPSEAKVSKRAMRKYYHSTAYPTSDVDLFLYGMSPEEAEKKIVTIYEAVRDSVPWDVTCVRTKHTVSIYSQYPYRSVQIVLRLYSSPAEILAGFDIDAPCLMFDGSRVLANPRAIVALMRQCNTTDMTRRSPSYEVRLAKYAARGFEVYVSTLDRTKVDPTIYERSINRIYGLARLLVLEKLKDGDSRVRFLEARRNLRGRPNASSRYYRRKKKYKGDLKGDMDIGGLEMNDYDVVSLHIPYGPGWDARRIEKLVYQTDLGINSIFNPKNKGRRLHRHPAFFGTVQECMDDCCEVALKHCPQPIDADERKLQEEEDKQYIRGRISFVEEDPGRQSMSGSFNPIDDQEWSEQVYVGPTPQFFSEIVSGNRDAVKAMIQADLEARAALQAANPDPEAEVKDENAPADIVNKRDIVGRMPLHVAVLSKQQVIACDLIDAGARISSRLADGRTALHLAAELGLGDVIKKLLAKSKANEEERDGKLGGRQDEDAIMKDVKERPSSEDDWTSDDNGVVSFDEDEEMKDADEDEAEEEDEDGDDEDEDEKASPKKKAAEPPETPAPESGALPEDEEGEPDILDINAPDWDFCFTPLAYAIVFSTLPIIDLLIAAGADCNLVTTGQTGPAAAPLMLTSYRADRDGNEDTAVEIAKRLVEGGAISSAANDSVQTIFHTLILAGKTRLVEILLKVDPKAAAVINLPTINYISHVFPIVSALSKTDYEMVALLLAYGAKLVFDPEDIAKALDIAKQQQRHYYSQDSDPLTQAVTPVEVALATHTELVQLVVSLGGTINRGTLSSLGRYVSPQNRRSLLDWCQYGIAVINKQLREEEEKLKEKGEDHSEDTSLFGWKAAAAKMQRGWTHETRIQDEKRLAQQKKQKKQDEDQRRKRLALKGFFADVERLLVSKGAKTYNEVYPDSEHKSTASLIEVNASGYPSMSTTSTSTIKTKYYQLSSNYSRSAVHMHLNDKYDELYEAAYTGNNEVVQRLCLPTEGMATESPPLQITVQLAHPTSEYVNTGITPLAAAIEGRRWKTAQLIFSIAAAQYKPEDNGEKFKINDISFDDDDDDNGSVGSDDSDNTVEGRQQISFVDVANRRSAVQCNVAPELLLKSSIAWIDKKGFQCQDNFLPKAVKSGDFEAFVNIANIYKLADPPLKIDENNLLDAILSSNNVEMLDEYIRRTGKEISVKLPSVDEAGETAHAVTDSTKLYLGLNVHGKKRKDLATRNDPNAMRSLDESRTPLLWNAINHGALDIIDYLGTSRPYEAYKCYAMCNSDELAITLRRRTDLEKLLPGLLGWSINAVGESPLSAAIMAGDLPTVKRLYGKEPKLMASAMKQRIKFVRYDPLLLAAACSQTDKDMIDFVLANGGSPLDTEPEDGFNIYHLLAINSNIDVMRHLLQKFPRELSETLLVQQTRKKTRTPLHIAVRKRCKTMVALLLDFVKLNPELERRILMARDAIGDLPLHSAVICGFAVITQLLIDRSPVEALHAENGVGNTPLEIVLLKDNDHKKTRIMPTSNVSTCHDYHFSPDPEPDRFRLDHLEKKVPGLRKTIAVLKEDGKLSDSNMAEELAKFARHMETKLTAAKAEAEKSGKEKTDEKEEKEEDKFDWYNGSWEDKFDCYNGWDGTLKAVREAVTARPALRGLVHVSDVQKSVARDLETAAQAPTDSYSYHRRQKDEEGLEAEEKEEDELKRTSAIFTLIMALDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRI2</accession>
    <name>A0A8H5GRI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRI2"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37240" checksum="E0B3B9DF5619EE45" modified="2022-01-19" version="1">MFVTTPLRSVQRIISLPITHVGGRQSTSNTLASQKTPPKVLTYYHFQVHLPHRKAEQEKQNDNLSRLNPRYWVTFAQTKAAQTWSGFGNAPEGSWKLRVFRGGEALVDRIDFEELALKGVDPSLGPTILRPDFSRKDEKAKDYKISLLFPPSVHTGEASLSYLRSLVQMHTPRHKRGFWIWLLVSPFTAPFMIIPVIPNLPFFFCIWRSWSHYRAYRASEYLKALIEHGQVIPEASPILDAIYKDFAPKPIESSSSSASSPASSSKRESEDSPLLNHETDTPRLLLTREAVPAIISACNLKESASTDLYRALEQAKQRLASEYPSSNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSD3</accession>
    <name>A0A8H5GSD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSD3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59363" checksum="6B9C355F0704D62A" modified="2022-01-19" version="1">MLTMIYEGTGFPVLVSLLIIALAILYLQGNRGPLPPGPPRLPIVGNLKYLTVLGKPRPWHLFYQFAQQYGPLTYLELLGKPVVIISSAKAATELLDRRASNYSRPHMVVGGEYLSGNLNFAISNGDIWRRMRRASQAQLGVKTLIRFQDIQTDEGVLFAYEMLTQPEKRKENILRVTASVILSILYDQPPLRSLDDPSVRLMDKYADKMHKAAQPGTYLVEILPVLKYLPTFFAPWKKSAKKDFQAFSSMFLRKYEVVKDRMLSGEQRPSLCAMLTESASRHELNDLESAWAAAILYGTAYDSTSASLAWFFLIMIQFPHIQRKAQEEIDTVIGRSRLPSFSDMDHLPYICALIREMLRWRPPAPFGVVYQSVKDDYFDGQIIPGGSLCIPNIWTINRDPQIYGADANEFRPERHLTPDGKRLKDEKEESHFTFGFGKRICIGRYFANKALFIDITMILWGMSIKPSPNDSGQIVIPSTSEDVGEGFISLPPPFECRCEPRFAGVEATLKQAHDAVLLGHMMAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSY6</accession>
    <name>A0A8H5GSY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSY6"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5370653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="343" mass="37485" checksum="A7950BF938FC59BF" modified="2022-01-19" version="1">MSTELLAKKKKSTTTEAKAAPDGDHRKRRRNRTTQSCLNCHTSKRMCDRKRPACARCTQLGLTGLCVYEVDDPNQRADAPDENSRLLKRVAELEGVIRELKNKPNPRWMHHGNDLQSGSEPISTPANTCSETLPSAQAPFHSPPAGSPISSSPVSNSPPATPSPLTPVYCDFPSSNALFSTAPHSPELDLNSFFSLYPELWGSADAVNQVFRHEQGNQLCDGDCSCLLEAPSYSVLLELSLRLRKAAETLSQSPSHLPGSRCSLNQRIRELDSLATHALCSIDSISHQKGGSMDIYPSGSSPMLSQTLQSSQTWGLSSSTVSPSPAVARYDDMFMTWEPTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUM2</accession>
    <name>A0A8H5GUM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUM2"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58363" checksum="498D079FA1973BA6" modified="2022-01-19" version="1">MTEFIDLPVELLPVILSFIPNPRSLTHTCLVNKVFYQFAVPRLYERISIYSWQKHGKERVIQLFICLSENPHVATYVRRLEIRDFPKSLPTVDGNTLDPTDIIVRALKNCTHLRSCTWTRDGSLNSEILQGLKEHSKELEELEINGHNEGNYGANVLLGFEGLRKVGLIMPGAEVVRNLSPWFGQIGSSLRHLTLICKLSSLITDTLLERLAPDMRHLDYFYLTGCPKVTERGITSVLSQNETGIVGLGLEGLSPKFNMAEFRSSCEHYSFFKRLRTLTLTIHQQVPLDEWTRQVISILSPAPSDCGSIPVPVLNLPPIPLESFQIYSTGAFFESSSITNQFWFNLVDAHHGWLKRISVHRMLISLEAIEEICRRCRELEELFVVVEPGTLHQLASRCLSIAPKLRTVHVNYPLEAQASSPTQSQSQTDADRHPTVADEDTDTIDSEFLPVLSPQDALAVVQRCPPTLTQFGCNTRVWMINKQVEINEQGNPVGIRRELARYDSPDIPEAFLVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWB6</accession>
    <name>A0A8H5GWB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWB6"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="500" mass="55587" checksum="A24E4BC010814071" modified="2022-01-19" version="1">MTELFPAPSPPPSTGCPSRLPGANQESTQALRDILQDNHDKYHIFFDDFGRHNHISHHLVALWSMGSPKAVLEAAYEESQPVQRPRGTAPEPITRDNLYDHLGDHKYYAGYLEYYEGVVREKSAAAALQECVFSPQANFPKIKSGQAENPQMLDRFLGAIMHPMIHVGYGIEFGLPGLIAEGLAMAASHRCASFIPSSLFAASTPESLVSRVQNTLSLKSAPVKPRVHAFNILARILREPQFKVSQAPDFMTMYGHVVQGLRDDIFKTVDDWTIDTSTPEGIQKAIEELQFVCTLLYAVPGYREPEPFNADFFYMHFATSSLFLSAIIPILPAASQEMLLRGFFAVIISWWILNGRPNLAISNFFSADTAHPTITSANTVQAHAHALPSPSSPLASNPNPWTSIVSQSLVHPDDHLIKLVRALVHYATLYGSRAASEKDFLDTGLEGAEKIDGTLFIRAAGLTMDRILGQMPSRENLKEYVMYWDREGFHTWSEKGKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWH9</accession>
    <name>A0A8H5GWH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWH9"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58402" checksum="6ED8C85C6FAFA8BD" modified="2022-01-19" version="1">MSNSRQHDVTTGSKRSDDPQQQYYSRARRSSQQKSDTLEEISKQLGKKITDLQDETRIQRVILSELATVNATLLSKCRLLEKENAELWNEIFRIKGPVFPNEITDIFIDFLHKDRASLAACALVCKDWLAGSRYHLFPSLTFNNSSSKRQSNLTELIDHPLCTFKLSVRRITLERVDNHQAADGESWLSTSIPCLSEFPSVTALRLVGLTPQIVQSSLFAQLWTQRQFLEGIIKLNVHKSEIPLDSQYLLEHFPNMTALDYIAEAILIFSPAGHVPLYHPFAEFLLVSLPEKWRKVSLTFPRSVWGVGMKRWFRLLRRTPTTVDLTLYEVRDADIPVLAECLRLLGPTLSSLTVGFAEERSQTSFYTSNILSRNTNLETIFLFGSLFYDSTRKGYLESLRNAPSLLSSIPNAHLRRIVLAFVFGDFSGLPVGGTLLPSSVQEDICSKIDELLAPSSASDSRSSRFPQLEEVVFKLCPPGGAFSVGTGKDLMDQVEEVWGEHFPNVTASGLMKFESEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX44</accession>
    <name>A0A8H5GX44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX44"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="69" mass="7440" checksum="77332F373A557E6D" modified="2022-01-19" version="1">MAHFVVFGAPDFLKSIDIPLPAIPPLPPIPPPLLLDPEPKFLHPGLYSMVIEPSESDGNGFEVAQPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0T7</accession>
    <name>A0A8H5H0T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0T7"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="634" mass="69507" checksum="6A3E168C737ED608" modified="2022-01-19" version="1">MVVKQELFMTDISNCVSSLKKVVQEFQSGAVMEATLQLPQPVLKAAAVTIAADPNAAYMMDFDALVATASANPPGPNQIQAEAQDDDFNPEKPAKRQNKPTSKRSTNAALTEDVRADMCTLKEHHDHLLSNSFDLSFQGSAGGLDASSSQPDPGFQPIDNFFTLNDLDMDIGLGDELARELGEGWGASPVRNAMEPQQIEDGNAEMDVDLNFMLDASVPMDTAEDNAFFNDAFFAEQPDVLMDQLKTPLKQKAPTSSAGRKENRTPGSRARSVDPTAQVLSPTTSFSRLFLSQVDELAPASPLHDITAHPNLKTNKKPPSKKQKRTRLLLDPRTELTDEELKLARAQYLQGQHELRRDLDTKRLEKDSGQLLEDMIWGVPSGINAPILVDFWQENFKVQVEARTGVVRLHMPDDEPPSKRRKIQKQVVYEELETARSVQEEAPVDDMPEPMAEDHFGLGLDFGVAFGDDFGGGANPEPEPSHNLRSSEEPGQGRRDSRQLSIGRDFDFGPSSNDLNAGSQRSSLFPWDNAGAGPSSSVDFGPDRVSVDRAETRIRSSPKVNSRRESSVGFSQIGSIGRGLSPADLGTRGSQVFGDDFIFDGVDDTQGNTLETQQTQRTEADLAALEKNSFNFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H117</accession>
    <name>A0A8H5H117_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H117"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="51"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="340"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="478" mass="54637" checksum="C52A88BD1918F250" modified="2022-01-19" version="1">MASTPMAFQTSRRPLLVNPPAGLSSVIRKKLMGYVGFANLPNQVHRKSVRKGFQFTAMVVGESGLGKSTLINTLFNTTLYPAKEPQPPSAEKPKTVAIESIGADIEENGVRLHLTVVDTPGFGDFVNNDDSWKPIVEDIESRFDSYLEQENRVNRTKVVDNRVHACLYFLQPTGHSLKQIDVEFMRRLHTKVNLIPVIAKADTMTDEELAAFKQRILSDIEHHNIHIFQAPTYENEDEETIAEAEEIASKIPFAVVGSDKVVNTPDGRQVRGRVYPWGVVEVDNEEHCDFVKLRQMLVRTYMEELREYTNDVLYENWRTEKLLGMGVAQDSSVFKEINPAARLQEERVMHEAKLAKMEAEMKMVFQQKVQEKESKLKQSEEELYARHKDMKEALEKQRLDLEEKKRKLESGRPITPEKNSTRRKGFLPALLQFLSSGMLLTIHLYVFVFFSMLIGIVLVLLEQAPPSFAWILSTDPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H179</accession>
    <name>A0A8H5H179_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H179"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5374944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="499" mass="55577" checksum="CD65E6ADF7814EF4" modified="2022-01-19" version="1">MSDIKTIGAQDVEHLPTYPVDEKSDTERDTGREIDPQVQRSLLRKFDYAILPPLTLMYLANALDKGNVGNAKTDNWDTDIGLVGNQYYLLVMIFYVPFCLFGTPISMLVKRYSAARVLPIMMFGFGSMSLFAGIAKTFGQIFAIRWFLGIFESAMLPGTVYYLSTFYQRGELASRVGAFYAAAAIAGAFSGLIAFGTFHIEHSKYHSWQFLFWIEGERGATVTFAIVAFFWLPRNSDTWWMLTEEEKAVARARILEDSSVTIDEKFNIRDAFRPFKDPLYWLWALISVSLGVPLASVNNFLPQIVNSLGYDKLKTNLYTVAPNVVGTVALLILTFSSDFFRERTIHICIPLATTLIGFIVLGAIDPIAHRGVAYFACFLLTMGASAPSVLVATWYNNNTPQESRRAVVTAVMVALANSSGLISTNVFRAQDEPKYVPALATSAGFGGVCLLMVAGTGIWMRWENRRRNIEQGTGNMRAQDVPTEALGEGPKSPSFRYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1B4</accession>
    <name>A0A8H5H1B4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1B4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="105" mass="11219" checksum="7F53B454296F32B5" modified="2022-01-19" version="1">MDPSPSFRSSTVEILAEAPASRTTTILVTLQLAPSLKLHAIPTKLDSSKVPTSIGSLIPFNVFSTRLCRMSVCGYISSISILKKAVGGLGEELQMRGLREASEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H201</accession>
    <name>A0A8H5H201_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_000001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H201"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="497"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="694"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5375212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="135028" checksum="BF345FD585177D0D" modified="2022-01-19" version="1">MRTQLGYAQSLIPQVVLDASDTAWSLRKDSAPVYTNTILIPLYCAAISVVALLLHIVFVSKPVQRWFGKNSDESEPQAAIPLHASLVGEVREHIKEHGGLVIFSYMLARLAGSLVLLGLSITSLVIDEVKRSGPQDQDDASIMGKWGRKHPRHRYGAHFSKREWLEAAMSLTYLYTSLLALISVVARPRWSRVIIRHLNAVLVATFFVYVYRDLYPFVTYTSSPLDRHEGSLLWAKIAVLGFSAVLVPLLIPRQYVPVDPKYPMEIPNPEQTACILSMVTYRFLDPLVFAAYKVKHLAWDQLPPLNDNDQAHVLKERSFKHLDIYAGAPRRHMFFGLLHIFRREYIVLAVCIILHVASNFAAPLSRTWRPGDGHSSLVLDPLDPPWARSRYFRHSMTRTLVRCQAIITQLVFEHSLRIRVKAEAPSSSGNSEPNSSTDTPDTLSVAGVEETSASSLTEEETIRASTASITSNTAQSKGKKQEQKGEKEKEPTSDSSNLVGKINNLVTTDLENIIDGRDFLYAIVYVPVQVALCIAFFAFIGLAVMLIMFPVPGLIAKLTVTETLNVLRMIKLFGWEQKMQGRIAEKREEELGWIFKKQILELMNGTINNLYNLTLVMKQELTASAVFSSMSVFDMLREQLHIIFDTITMIMTGKVSLERVSSFLRETELLDRFSEKETDSNYFTPADQNQSEEIGFRNATFTWSNDVDGSLTPSKRKFLLKIEEELIFRQDSINLVIGETGSGKTSLLMALLSEMHFIPSSPDSWYNLPRDSGVAYAAQESWENILFGAPFDEERYRKVIHQCGLERDLTLFEAGDATEVGEKGLTLSGGQKARITLARAVYSSAKILLLDDVLAALDVHTSKWIVEKCFCGDLVQGRTIILVTHNVALARPIASFVVAMKDGRIESQGTVADALRKDHVLSAEAKENEQILKRSDQEIDHHPPSDDPKGDGKLIAAEEIEEGHVSWPAVKMYFSGLGGSYPWIFCIACVLASLMVELLNTSQTYFLGYWTTQYDERDDPSEVPVVLYIGIYATLLACAVIIYCCGYMVYLYGGIRASRTLHKRLVESVLGTTLRWLDTTPTSRIIARCTQDIRAVDGPIPMWLQWVAELTMVMIVKLFAVVLITPIFFIPGVLVFVFGSITGQIYIKAQLSVKREMSNAKAPVLAHFGAAIAGLTSIRAFGAQKAFMEESLKRIDKFSRAARTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H283</accession>
    <name>A0A8H5H283_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H283"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116501" checksum="110FD9F1D622FE34" modified="2022-01-19" version="1">MGDVDSNNYASTSSNSNPEHPAQQNMYNANVQASQFQSPLQSQWPQHQQLPQQYTAQWNGQPAPFLNAMSGAMNGMGGHMQNGINGLPTNVGYNVPIFSQQMLHDAFALSVPVAAAEEPLLVSSLVESRVRNENYKDTLNNLHGKNSHSAALWKDYYLEHKDRIDEQGPSPLKRQKKPALDSFDDDLSPVRSSSPATKSGKARGRPPKASTPNPTNSKVSTSRASSSKASTPVQSDFTLTGPSGRRHTINSLTVHTPVYNTRLPPPNSQVVIPEPPSRSPSPPTKIIPHVRGNKFTDEDKDFFIKFISWRLKSDPSLERLELCDELEKKASRYSSAPHHTSASWNSYWSNHHDLPDKILANAHALCWEEEQSEGTDKKRVFVRQRPSYKESSSEEEEEHQEEENESADDESDEDIDSIPLVFDESAMGASGSAYTDADLAILARYVATFPDFLVTPSKEKWPPYNARYPHRSAKSWAEYFRRDEKRIMKLAHKVRDQGLHLDSAPLPEKKPHWNPSDEVSGPPKAKRKFIMDDEKDEAGNHANTDHVCLSSDRYGIYTASRPVVTNSHHHYQLTMDEEYDVIVLGTGLTECILSGLLSKEGKKVLHMDRNDYYGGESASLNLTQLYRKFRPDQTPPDELGRDRDYAVDLVPKFIIASGELTKILVHTEVTRYLEFKQIAGSFVYRDGKISKVPSTEMEAVKSPLMGLFEKRRAKKFFEFLQNWKDDDPSTHQGINLDKDSMKVVYEKFGLEPGTQDFIGHAMALYLDDEYVLSKDSCWMMLTVVASYITKPARPTYDRIILYTSSMARYGKSPYIYPLYGLGELPQSFARLSAIYGGTYMLDKPIDEIVTDADGKFVGARSGNETVKAKQVIGDPSYFGAGQAAASKIRVVEEGKVVRAICILKHPIPGTEDADSCQIIIPQNQVNRRNDIYVAMVSSTHNVCAKDVYVAIVSTVVETDKPELEIRPGLDLLGPIYDKFVTISSQYTPTADGKQDNIFITRSYDATSHFETVVEDVQDAWKRVTGTDLVLTKKEVEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIJ6</accession>
    <name>A0A8H5LIJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIJ6"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="115"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5358686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="41955" checksum="1DC88D4D8E2EF604" modified="2022-01-19" version="1">MPQIIFPVDSVAISLKRRVEAPASQSSPESSPESRTKPLPRGILKHKECISALVEQNCPSLVEKYTAPWFLFNGHMQTLYCIVGDFTNVDPVVYRRGLDFTPPERDALPDDTPIVVVSHGLTGGSHEGYIRAILSPACTPKDKGGLGYRAVVVNFRGCAGVPITSQNLYSAGNTNDLRTALLYISKQYPRAPLLGLGFSLGANVMIRYMGEEGAQCRLLSGCALGCPWNLAHNGMAIAGSFMGKFWTRGMGNNMVGLVQRHATSLSGRVGVAEAVSEALALRFPALDKFDLTFTRVLAGYPTEVGVQEYYAAEGSHDALKEIRRPLLAINAADDPVVQSFPKTQEEIDSDWTTMVITPGGGHLGWFEPVAWDVTGTKRWTTKPVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJR9</accession>
    <name>A0A8H5LJR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJR9"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="7">
        <location>
            <begin position="131"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5359901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="684" mass="76151" checksum="83C364D59E7432CE" modified="2022-01-19" version="1">MSSIETFDPYTDKESRPVCSLVLSGSDMMSMSESQWKQALAFDELVFARTTPQQKLQIVMRFQADGRTVAVTGDGVNDAPALKQTDVGMAIAGGSNVAISRLCFENLRKFTLYLLLAGSFSELMPVLLNILFSVPQMIFICIFTDLSIVYEKPEAGLLLRKPRDRKKERLVDWKLLLQAYRFIGVIHSLTLMVGAFYFGFHRQSITFSALLWLKYGGYNVDPELLSEATNQAQSICREVMKTRFGTQEIRELATLEPVSPDRLSQFQESPLLFGPDYPGTQLNTLQINASSMAAAPWNRAVCQMLALEAENLVYTTPGFSLQLSGDDSPSWENLFACRLFDVFMEIQAAQQSSDLPLLQVLGDRYETKKKSNASQSARRRKFTRRERIGSTILQHAQVEFWTSVSSTVQMLTIDGMSDEETEQQDGQTVKVIKDPEFRHPALREIFQHVDGARKKEQALFIQSGGKPLRRVFTDQLLQKITHCLVFRVWISLPLAIVRNGILAVVISLAAASIGAVYSPTSADMGAQGILDRQIRPELVFCKTESLVNMQNKVKASSKNYLSTVVWKAPLFFLVRLLGGTLTLTCFAMGRKLGLSPALNFVLDDEVIREGLEELRVYGLPPVVPSTNAVVNAGVNTSSSNPKAVESILTTLSSLPHLKTLSIEQPASFPSCVGTLVIRFFGWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS49</accession>
    <name>A0A8H5LS49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS49"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="77605" checksum="F5E2AB4746855AE2" modified="2022-01-19" version="1">MSNHAGPAPMTASESDPLLPSKRKKPFYRPRPLWLVPFAITGALVRGMTLAPRVEVFTQLSCATVHKHHPYNHTNAILIPHNPEYMSIYSALDPVGPHLSSVHSTSVLLPSHQDDDDGAQEEDPRRLPSERCISDPKVTAGAARLQTIMTTTMGFLSALTTGWWGHFSERHGRTRVLAISTLGLFLTDLTFILVATPGSALSSHGHKLLILAPFIEGCLGGWSTLQSATSSYVSDCTSAGSRAKIFSRFTGVFYLGFALGPTIGGWIIRNGIPGIDRIGTLHGQGKSVTEVFWLAICCSFINLFLVAFVFPESLSKEQRARAIEQYHANSKGKGHASNQDSDGSVSPAPAEAPPKPGAIRRFLSPLAVFFPAAISRPTASGVVKTRDWSLTFLALSVLLFMLSTGIYQIKYIYAEHVYGWGADKLSYYISFAGGLRAVCLLFVMPAVISTFKPTVQKSTNKTASPTKAQLAQEIHFDLMLTRICICIDICSQFLVSISPSPSNIHAESIRSFLTSTPSQTSADRRSEIFFVLASSLSGFGAGFLPAAQSLALCIVQARQLLESTASERDASAVASDAREESIKPKGDSGIGKLFGALSVLQAVGQMIMGPLLFGLVYSDSVAQFPKAIFVTACGILVGALGFASLIRSPVQRERPRGKGKAPMKGGAHRTKSSRLSRAEEEERRGRSRASKDLFGYGVPITRDNEEQVQRSTQEAGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT20</accession>
    <name>A0A8H5LT20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT20"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="350" mass="38704" checksum="8E520C9E6CA55A45" modified="2022-01-19" version="1">MPVPTFPPFPDDVPTHPLLVVDYHLLKAGDKNEIDRLWEAATGLGFWYLKNHGTEEEVNALFDLGEETMELPLEEKMKYEQGDAGSSFGYKAAGANAVDASGLKDTIEFLNVAKDDALAFPKVARRSYPPNVNTKMPSVIQPFVRKSVEINMTLLGIFNDKLDLPEGTLQKLHSLEEYSGSEARIIKNPPGLSPERMAIGAHTDFGSLSFLHNRLGGLQVLPPGIEEWQYVKPLPGHAICNVGDALALLSGGTLHSNIHRVMPPPGAQNPLTRWSAVFFTRPGNSVVLRALVDQSDFIKNRVSKQPNPESFDTGVTSLEWFTRRIKNQRLKNRTGPETWLASRGTEQGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTD2</accession>
    <name>A0A8H5LTD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polymerase III polypeptide H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTD2"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25678" checksum="C6D2E83C5E08946A" modified="2022-01-19" version="1">MYQLAILKETTAIHPANFGVPPEQAIIAELNKKYANRVLHGLGLCVCVFDLTEVGEGKVRYGDGCLWYKVIFRLVVFRPFVSEVILGKVKSSDEESIRLSLGFFDDIYIPAIYLPQPSTFDPNERAHFWLPESDLTKPHELLDTPTAERMYIDTGEILRVRVESDEFYDDEPGPPKALEGVQVEREARRAPYSIICSIAEQGLGPTAWWKGEPVPEGDEMMVGDTEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU07</accession>
    <name>A0A8H5LU07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU07"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52108" checksum="F31A5B74F150ADBB" modified="2022-01-19" version="1">MVQEISSVATDSHHTASHNASEWDLLGDIDSIHDEFEVHDYTDAPLMTKEAYSQSPESRSSQYGSCQHLTAPGSCKDKVEQFDDPRLYLNTNAPFSAVVCGVQGSGKSHTVSLMLENMLVTGSPALGCLEKPLSGLVLHFGEGGKGSNPCEAAWVGLSDDRSVKPPPVKVYVSKSSLETMKNVYRPLTTRGNVTVEPLLFQESELDAQAFLSMMAVGSSASAPLYVQIILSILRDLGENFSYQGLLRQLEVKKKSFNSAQLSGLEQRMSLLTSFITSKKPTKKTGSAIAPRFAKGQLTIIDLSDPFLDPASACGLFEVIIRLFIRAEVSTGKVLVVDEAHKYLSVDQDSSALTAALLGLARQQRHLAMRLIISTQEPTVVPPVLLDLCTISILHRFSSVAWWNHLIKHVSADLSDDGAFDKVVKLKTGEAIVLTPSGLGTFACDDLENNRVVARFGRRYLVIKTRKRVTVDGGASILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUA4</accession>
    <name>A0A8H5LUA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 105 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUA4"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034914058" description="Glycoside hydrolase family 105 protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44665" checksum="51EACEF25C092FD1" modified="2022-01-19" version="1">MALKLALFLFVFSTAVKAAGLNSDVISSVRQNLVQTATHSWELGTAAEALLELDWPALSVFSPSAFPPPYQLNDTLNANDVLRIAENVVAAKPADSLALVPDGSAGDPASIGVAVLLANWTKPDPTNFTYSTAVGDQLNYLLNVAPRTASGAISHRTDEAQLWADFVYMTPPFIAYFGALQGGDSESALLQIAYEQCSLYRDGLRDENGLWRHVAEGSWQDNTHWATGNAWAAAGMLRVLATLNYTSQAQNFVAQRANLTSWIQEIITATWQHQSENGTLLNVIDDPTSFADSASTALLAYVTYRMALHTGDYTLIPNADKALQLVESSIDSQGLLRNTVNPYTFNTASTPDVPSPEGQAFVLLLHSAWRDGNFSSDSTSGGAPDGNGNAGNDDGDDDGSLFPQQCRLVMRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWK3</accession>
    <name>A0A8H5LWK3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWK3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034014787" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="59"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="365" mass="40644" checksum="6A47155BC30BDBFE" modified="2022-01-19" version="1">MLFQVLSSLLLALTVGASSALLPRVDVPAPFNSSLFEDFNVSRGLNYHYYAVPADTGKPTLLFLHGFPSTSYDWRHQVAFFQEKGYGLLVPDMLGYGGTSKPLDPQLYVSSLITKDIIDILDAESIEQVVVIGHDWGSKIASRLANYFPERFLAYAFLVVGYTTPDFFATPFEEKLRLDKLVLGYQRFAYWDFMASEGADQFILAHLDSFFNVTYTKDTTHSISADPLAVLAAFNSTEVTPADYVTPEERAIQMEAIRQGGIAAPLNWYKIARGTLEMQDDKGIPRENALIRSPIFFGAALRDYITGSAPIFLAGALVASNSTATIREYNSDHWLQQALPDQVNGDLLEWIEGLDLDLGGDYQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWY4</accession>
    <name>A0A8H5LWY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWY4"/>
    <dbReference type="OrthoDB" id="3228311at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="651"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5372622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="831" mass="93057" checksum="7BD07575EC4035BB" modified="2022-01-19" version="1">MVWFRPTFPVAFCNLSPVACGHNVRWGDSDPFELLKDSNSESSSTHSLASIASTNIVKVVKGATSKVRNVVQKAKRSVKHCRHSGQASEPIEVSDSGHSDTEESAKEENDEDELERLRARWTSPIYAFFGEKPSIEYENGRKYHYFKCKASKCKGKGGVRCYLDGSDRASTSNLKSHAVHCFGADAVDAAIKGLAEAKSSQNTIYSMFVGLGNRVVSISHQMHTDPERHAAVVRWITKSVRLLHIVEDRKLQELMLSGRLQASFPRRKRVAEDIKTAFEHCSERIVTLLKEYPGQISFATDAWTSPNHRAFVAWTIHLQHQGKLLVFLLDIIEVPKSHTGEVLTREFDKMLERHGLQQKILGFCRDNATSNDTQTTALDSSTSNSFSVEGRVRCLNHTMNLAAKALLNGIAGSDDGAEGKLPDDELEDEEEEEEEDLPTLLDNDDILPEREDDEGVDELEGIDDDERATFDWESAEVRAALEKVFKDATIYFSSEQHSSISGIIPAMDRIDDLLTAQTTTAPSSSQPLHSSVKAALRLAKKLMNRYYSRTDESSIYRISMVLHPGLKLEYFCRHKWQQPWINQAEQLTRNAYNEYVARSQSQQAIEETPTTAATLSTLSSPTLSAAAQTSQVNDFMNISVTSSSTVTARDELADYLAMPLENVTDPLMWWWEKQTVFSILSQMALDYHSVPATSTSVERVFLSGRQLLVFTRNRLSGWSICRFLCLGSWSKKDLMQDKDIMDALMKAEEKKAEKRKGKEKAKYKNKTSSLSYLVRVTRRFGGAGAGMTRTHESLGFKGLSSGGVFNSTFSATLNALWKLDQCPVSQQLRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY63</accession>
    <name>A0A8H5LY63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY63"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5373701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40868" checksum="46EE8F029119BDBC" modified="2022-01-19" version="1">MSFLTRNLPWFIHDPGVYIIGQECYTSLVENLDIFDTHCLKYAFSKALGIAIVAGGSVMKLPQILLIVRARSARGISLPSYALETIAYAIQLAYASRNAFPFSTYGENLFLTIQNIIITHLIILYAPPTLDLASSLSPTAFIERFNPRQSQHHRHPHPIRTPTRLSLTSRTHLPSKRSNLLLCTSLTLLALLFLFTPFLTPLPLLSLLQLSTLPLSLLSKYPQIRQNYISKSTGQLSVIAVASQILGCLARLYTTTVELGWDWEGWLVGLGFGMALFLNSVLGVQLVLYWGKDVVERERLRRDIMMESGGVLSPVVEEGEMDEEGEVRDEGFVMRRSEGRMRELNMTSNGGTVVWEVPKAGGGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYX7</accession>
    <name>A0A8H5LYX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYX7"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="870"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="375"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="613"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="735"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5375140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="919" mass="102447" checksum="12296142CAF08E5E" modified="2022-01-19" version="1">MFSQFRQAVETFAPQQTRKGSQDAEGPSHAARSQSIDSQRPDSPGQLAESALSSLRKSFAPRSASPASAKSPITSPRTKSTLEERLRAVTHTLGEASNGTTPTSSRASPLPMKVAVDHPLSPTSTPLPDSPIVSPIVSPALEHVGHNLSLSVASLSDVTPAAEPASVSEQEPVEENAPNDTIPSVSTEEATHQSPPSASVGKEVEESAKDNAPPGQDVEDEIEEVIESLAIADESDPTTTKPVEPLSNEGTVMESNDDVSTVVAEEAEKEMEDVPTQHERSASPVFAIGTNVVAEIGKDVEASIAQNGRNTSPGVNTGTNVEELQERLKLVEQRFTDVSKSFKRLQAEKVAADSVLRELTPVETLQDSEGLRSYLQNIASKVEISQEEIKRLNEKLQGQDERLEELRDTHRLESHSQSEQIELLRKQLQETEALLSASQGSIAQGEDDLGKRQADINRLNQEMAKAKESAKEEEEKRVKAINLLKTVRQKLVKVEKEKEEAVKELAGVREKEASQKEKEDAEKAKLQKDIETVNAEREVAVAGLKAQFDKELLAMKERHEKEISAIRSQFELEAVTTKSVHTKVLNAKNFRISQLEASLETMSNDKNSYFDQLQIRQAEYESSQEQVEMLRNQNTEVQHQLREYADQVALLKEELLEFQRQQIQPTPSVSSEDTARLMSAVEAKYEAKLADLRRVLQNVEKERSESDIEWTRILREKKRETEELKQMLGSATKSKEQDEDVVGELRAQVARLQEEIQSNQTRISQLTTQLSQFQDVENSNQSKETELTSKIEQLERTVEEGKTRESQLRANVKTLREEIRKVQSSAALLDRQRNRGVGYWSSRNDGHPPEASNVSSPPSGRSSTSDPPAKEQEEVNLEYLRNVILQFLEHKEMRPSLVKVLSVILHFTPQETRRLIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ71</accession>
    <name>A0A8H5LZ71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ71"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5374947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31651" checksum="CCE527EBFFC3D177" modified="2022-01-19" version="1">MKHGVAFRKFSRPTAHRMLMLRNLVTSLFEHEQIKTTLPKARDAARLAEKIITLGKRGDLSAQARASSFLLKPSLLPKLFGIFAQRYAERPGGYTRIHKFGNRPGDNAPNAILELVDNPKDLRFEMTSRAVGWELLKEKMKAHKPMSVVRSGLQGTQQVVESERKIKFGEAGGILRPATRWNLQKVLRFRNPDASLKLSENAMNHADRLMLTPWASKKMFDETDKQSKPGNEEAPLKAGQLAPGDTRSALHLAQGALGHQKPPPRTPVLTMNYLLGRKPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B3P9</accession>
    <name>A0A8H5B3P9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_018112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000490">
        <property type="protein sequence ID" value="KAF5315990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B3P9"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5315990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="979" mass="109228" checksum="0B73579BD4F2B48B" modified="2022-01-19" version="1">MARRKRLLDDDSDSDSYQASEADDFGLENDPDAREERALFQNPYQHKRRRKNGKEDAIYGVFGDDSDEEDSRKGGKGKGKRSDWTKAPAFVTGENKVDLQEDDAKMDVDSDEDDTEGEGEGQSAEQLSDDDSEPSRRPSPRIREEEEDDIQEPTFPPVGGIGSSKGGIGSSKGGIGSSKGGIGSSKSTSTGFSSASFSKGGIGSLKSTFAQATATDATKTPPPPGPTSADVTEDPSLPSAFAGSRSTSFMRDSKPAARPGTSLSREEQAHFSKLSGSFGSRMLEKMGWKAGTGLGVTGEGIVTPVETKLRPGKTGIAFRGFKERTEQSKREARRRGEAVSDDEEEDPKIRKAKKQQKEAKEKRSDVWKKPKKVKTKVQHKTYEEIIAEASEEAPTAAGIGQIIDATGAVPREVSSLADVNLNTWTPSADPTRIPEVRHNIRLIAESCKTDLDGLAREAKSLQERKKWVAQEDVRLRKKVEDEAELIARLQQVQIVANEIDAKAKELASVYEVSLDPFSPIIYRLVSEFENEFTRYRLDEVVVAAIAPLIRRMVAQWNPLEEPTTFISTFRNWRRALLINEEKTPQMQVDVYGSQTISVTPAIEKPMTPFESLLWNVWLPKVRTAINNEWSPKDPQPVVKLYEAWSTFLPPFIRDNMLDQLILPKVQKAVADWNAKLDEVSLQTIVFPWLPHVGLRLEDVIGDARRKVKSLLRSWTVGDRIPTDLKAWRDVFDSKDWDNIILKYIIPKLGATLRNDFHINPRNQNMEPLETVLQWADLIHPSILSQLLETEFFPKWLDVLYIWLASPSVNFEEVAQWYSFWKDAFPQHMQNLSGISRGFTRGLQLMNQAIELGPEAPTRLVRPDYRSERAQAQSSAEGQKKTKATTTVPSRSSARTQEITFRSIVEEFAASHNLLFIPTGKAHEKSRMPLFRISSSADGKGGLLVYILDDAVWASMEGAGGPTEEYRAISLDNMVLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7C1</accession>
    <name>A0A8H5B7C1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000461">
        <property type="protein sequence ID" value="KAF5317925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7C1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="63513" checksum="6751B7D1BE4DAC10" modified="2022-01-19" version="1">MSSNNANNNSESIFNVPILNTTNYEFWNYAITCLLEAKGLSRVASGTQKHYVNTSPTETGNAPSFPEGFVQVPDEVFNALTESEQSSYNQIIDTFADQWNQHQILVKKHDWESVETYKLQSSWDDKDEQALGFISSFLPNDVGLEMREFNRDEIDENPCAKAKGDYTSHMLWDKVDKKYSSPGPTSWFLDFKEFMSWMLDEKKDPANQIASLEAVLTHLKAYGFTVDDKFRALFLMDRIPQSWGNYAQFTLATIKPKNLTMAHVEGLILIEYKRRTGQSSESSLLTRITGDRRKFDSAPNWNTQKAGSSKQKNQNKGKGKQPKPQEPSNNVTTGDVNQGGDKKKKTCRSKKKKGSKKGTAQLANPEVDADSDSNDDDAPLMVTAFMANPFMNATLDPIEISDTDDLPETCEQPIYELLPYHNFLIVQSDCFIDKNNDSSLKERVKQNLAKQVRPQTISGYFILTHYERLMINELAQETVDFESFLRVEACHQMTRKLAKIWDYTYNSDGTHTEPYLRAKEDLNGDEDMTNQWFDHEGTIRPIQKQIGKRLSIFAIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BH68</accession>
    <name>A0A8H5BH68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000395">
        <property type="protein sequence ID" value="KAF5323205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BH68"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5323205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="62586" checksum="05C9DF4D3D14A03C" modified="2022-01-19" version="1">MLRLRTSYSPPLPSGPTSNYPSAKKLHIYLSNSPPRYPPPTLSTTPLSVSLYGGYNSLNEAHAYLALLLPTAPRWAAFLLPRSIHETVGTPAEPSDPNLGHAAGGGVAGPGTDAVFSSAPLRTVQIFHDPTHISIDWSRLTFLRLCPAVCRNLKVARVLKAMELGGGGAMLEELIIGCNLVQEDEGDFARLLGGPTDKGKDTKFTITSPVSENFVSNTINQKLAKSAKSKSKQALEHNNSSSNHTNHSNNNNNNGSHSQRAQLNNRRIDEDQSLHSHLRSHSDSNSTLPTSSSAMIRTIHPNTHTSSFSPFLPFAFGERENGGAPQLLSLLILPALEVFEDRRRAEAGNMLVMFRMGCLRDVFVRGAAEEAQKEMEMEMETVGENQDGGHGGVKLYYAAIITLTTLITPASITEEEFISLLKAAPRLERLELRGGVKGLGNAGVGEMVGDVGVVIVIAMVMAIARVPMVLKSTGLGKEKEKEKEKKRQKTQTQTQTQHNHRKEKKGETRNPQNDPSPKTPHPSPPWDLCFDASVFVDMVESRWGAALAFITITPTPIPTSTRPQRRRCPSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BI14</accession>
    <name>A0A8H5BI14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000392">
        <property type="protein sequence ID" value="KAF5323657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BI14"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5323657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="119" mass="13362" checksum="4FC0B8EF274A5F15" modified="2022-01-19" version="1">MPPKSRIKQYTCPDCAAKYETQRGYKKHVGVCKRRRANDDRVFAAAAEPPHSRARVAGPSTLASQEIVVEELMDSDSDDGTVEDETSGDKLGIVDEMEVDVVVERMMPQGRRTHKTWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRD7</accession>
    <name>A0A8H5BRD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000379">
        <property type="protein sequence ID" value="KAF5327960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRD7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="427" mass="45497" checksum="883A1B555B685795" modified="2022-01-19" version="1">MTSRGDNRKLAIAWAVDVDVEVDVNVYVDVDVYADVDVDADVDIDANADVDVDVDEGGEVGVDKGFGFKFEVAGKEEVVGEGVEGGDDKGNGNGTVAVGLEFGFGGKGASVIEDKCKCKGERTAEDDADADEDRRGEDEDEDEDGIKGYKDDVDDNDDNIKDMALVGLELRLGLTPGMVLGEDKDKGDNEDEGDDDDEGNADEDVEIAISEGEEEDSGGNESDGANEGASQEEEGGVCGVEGKGKGMCGYERRESESETDCGSESKGGSGVEDEDDTVTREWEWESRSTTRLSSFLSFFVFGGESFGFGLEFVNVASASPKSIFRSSASTLAFVSVSFQFRLFVPFSLRSGSESALGIVGDEQTPTTIFVSVSKTLACPDPDSDPNPNRGPHPCPPSLVYPLAESRPVSMCMISSYRYLRTSLFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRL1</accession>
    <name>A0A8H5BRL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000381">
        <property type="protein sequence ID" value="KAF5327939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRL1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="90"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="260" mass="28025" checksum="BC674E103DB8ADE2" modified="2022-01-19" version="1">MNEGSFIFVIPAYLINPIGDIDVLTLPERSLTRTGQYKKEDYSTLVHQLFPYVLVHTFIVMKFTLVSLSLLFASSSVSALPGKLEAQDDDIETQAVDLHNSYRAKYGADAVTWDSSIASQAQAYAEKCVFEHSTGADFIDSGTDGVGENLAAGSGDYGISDAVNSWMDEAYNNPGFSSDTGHFTQCLNSTKVVWKATKQIGCGIGSCASGTIFPDSDSKYVVCQYAPPGNYDGQFPSSPDVVKVHVLNLLVIAVKTSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BT77</accession>
    <name>A0A8H5BT77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000346">
        <property type="protein sequence ID" value="KAF5329117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BT77"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5329117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="388" mass="44101" checksum="D0512A510401F30F" modified="2022-01-19" version="1">MSENPASATAATGGTQAPHDATPPDNDAQSSVFPNMTTKEQGVKPEKFAGDRNQTKDWMAEFNNYLRLNDQVYPTEEEKISFFLTLFSGEEAKRWAHNMMVKVFEEEDDFSDSDEEYTSTDEDSSTSKPKTKGKSWTLREVKREFLRDFKPSAQETQAQTKIEHIKMEGALADIDKYNSQFKRYADDTGYNDKALMKYYRKGLPRGLVDRISYLSTQPRNLMALQKAAVKQHMIWLERQEEKTSWNKPRREEGQSGRRSQGTGSSQMRSMEVNAFQDNTPGASSITKYPPKLTPQERDKMRKEGRCFRCRGQGHMGNDCPTFPSTPPITPNNTTWRPAIKKTAVSTETSDPKVNTTLDNISELTARIGALSGEEKEGLLKKFVMESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZS5</accession>
    <name>A0A8H5BZS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000315">
        <property type="protein sequence ID" value="KAF5332041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZS5"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5332041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="435" mass="46550" checksum="224403C5151303DA" modified="2022-01-19" version="1">MLLVDIVNKKSLSSSKTSDPTKDLKNVALQASSTLGSTSNTPMVNKANISMGIQCYNCKGFGHLSQDCPTPKQKLNGGGNGGRGKNWHGRGRGRGGGNPGGHGGANANNGGNTANVEGTPKPGNTMTPSVALNSNPKPNTYLKPAGQAGMAENINFAYMAQLSSDISEDDYHITDVTDKEIGPLTTDELDHIESTIKQLGNQLPDEKRKVLWQLNATLVAQHASQWLYEKFAYEVWEDEEDEENGSESDSEDDFTMESGDEDESKEVPDVRGGNDIYMCVTDLTFIPDNGISIDKSSEPVVMQTDSMEPTASVFAVSNKSISSKTIVLDSRCTHHMSPNPSFFSHTPKPCPSRTFRSANRGKFTASSQGAAEIHTGEGTIPVRNVLYVSELANTLVSIGELDDAGYTVTFGGGQAVIRGPDGKVCDSILKSNGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C008</accession>
    <name>A0A8H5C008_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000310">
        <property type="protein sequence ID" value="KAF5332349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C008"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5332349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="250" mass="27922" checksum="9958C0040147AE85" modified="2022-01-19" version="1">MAPRKRRATANATSAFMRNATTTWATTTASNTSTNLSSGFTPLDTLDTYFDSQITDLFQRQLNTAWMSYARERQTHYKDACGQPQYQDIRKSKTEGYFGQGFPAFDEGLFDSGICWRRILIGSLRGLRLRSQHEYLNCPTCAWHSAKVVQTREKVSFFWFHVGVVPEKQDNVGREAPYLPLDDLVRLGSTSTRSAMMSLVDHSPALVSNETLPSEGLGVGLEPLSGQAELGIGPELSLDGEQWQEAKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C1B9</accession>
    <name>A0A8H5C1B9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000292">
        <property type="protein sequence ID" value="KAF5333024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C1B9"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="709" mass="76420" checksum="51281AB1EFFE95C1" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILLAWLQATGLSSVLSSDRPSDAEVSSASPLSAEDAAAQAEAITAAQKKQADWDEKNDKAIGSIKLRLSPPVRQKTLGMTTAKAIWVFLKKTYGKPGVSAIYTDFKRATSIIIPNDANPSAAIELIRMHFDRVSAAGIPTDDPSGPSLTKITNFLIVMFIVSKLPPRYEYLINMYTQCSIQQVDEQNLDDLQSEILNIWESRQGAFKGPSGKAQANRLSAVKQKDGNPSFQQQQQQRPSGSSSGANGASGSNGNNKGKGKGKGKGKAHFRRGGRAGKFEQAKRQGQAHLVHEDMSPMMHTVTVVDTPAAVDTRKPFFMEKEKPFDAFFTGTKRAINLARDIGARPSGETVATLEDVVMSHPDLSSFTSLTPAPRPKHTLTERIYWSNLQSSSDGWGDAGNWNGWNGEYPGTQTGSDAVMACVQEEDADSNEDTLVNTSELGSVFGSTMTESGVKVPQDTRTPVPLIDRLAQDPAADILQCGIHLGERFQNPEDSLHIYGEPLRAALNTVAPTGTLSLAQRIAAVRSEMPSGSLPAHPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNKDGRYDELIDWQRDATIGLGGMELPSRVPTPSSMPELRSMSPSLSETSDLEYMSTPPSLSRMSLPTSPVEDTWSDGIPSPRPSTPAMVTVNAANNYGWSLDSEVSGMDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C264</accession>
    <name>A0A8H5C264_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C264"/>
    <dbReference type="OrthoDB" id="3242468at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="224"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="398" mass="43009" checksum="609D7F3CD5D610F4" modified="2022-01-19" version="1">MASYLRNLFGSSSSRPTSQRSQSSSSKSHHRTRSVPSPINTNTAYVYNGVPSSAAPASAAPGYTSSSGTRSHSPTTSRTTRPSPLRYNTYDSSTISSKTRPTRPLPSSSHGSISYKSGDAYLPYPIYTPTATSTYSSRSNSNSSMAPPSAASGYAPSHRPAAPRTSSSTSVASRPALKQTHTWHGHGSKADGPKHHVSFVNPNRPQTLHMHPLLAASSHSRAPISYDVIYPPSAQTVVDRTTRTAVPSHTLTQPATDPPTKGTLVLRSDKFPWPVVVQPSFENPRKSAAKFYLGESSSSHHSHSLTQGLPVTNNDLIRAIHLTLSARVTREEWDALGKGSRAQRKVTRAYEKRTRLMGDKEGGVRRVDWLGEKTRLIGIEVDKTASETGVAKLVFGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5R0</accession>
    <name>A0A8H5C5R0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5R0"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5335615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="205" mass="22786" checksum="0F6F79D25F0453BA" modified="2022-01-19" version="1">MNWVGSQTMAPCVYSKKWWFLLFMDEGSTGSEDDKETEEGSFVVVVLLDLICNIHGKASPASGVDDQDIFLNKMPDNDNETAGSVDQNIWSVAWLLEKKCSKSYTKWSSTNIHPSNNKNKVGNVLNAFAHFFYQESQKTMVIADLQTSTLGNKKVLFDMMFHTEDGGSGVGDHGEQGITIFLTAHECIEGGRCELLELDSLTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB78</accession>
    <name>A0A8H5CB78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000197">
        <property type="protein sequence ID" value="KAF5338298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB78"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF6535" evidence="5">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="441" mass="49677" checksum="B89C341FC9E9B5F7" modified="2022-01-19" version="1">MSSQRSSNAQDARTDSEVRNVMEEKSKSEPMANNNEAAPGVQVNQILKRPRTGLDVLLSLITEAQHVNETKKKKGNLTGYWASQNIRVHTLDELGKEASENARVWKVYLDEAETFDDEMLKGFRDTLDALLVFILLKIRWGNLGFQPALKCYVDLDWNSIQAFIWDTLRRRDETDNHKVFKVLVENGADVNAGKGIMGLHCKQQHLGDLDIVKYLVEKGEMLMQREGIWVCIASSSIWGHLDIVKYLVEKGADVNAEGGFWFALQAAAFGDIWILSTAVYWGHLDIVKYLVEKGADVNAEGGNMGFIASSSRWGHLDIVKYLVEKGADVNAKEGIMGLHCKQQHIRDIWILSNIYLIERHLDIVKYLVEKGAYVNAKGGEYGFPLQAAAYMGRLDVVKYVVEEKSVDVNGKGQKYESAFKAAQEGDEPEVVKYLREDRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CES5</accession>
    <name>A0A8H5CES5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CES5"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="75688" checksum="C0D488A90AA543EE" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILVAWLQATGLSSVLRSDRPDDAEVSTASPLSAEDAAAQSEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLGMTTAKEIWDFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAYGIPTDGTSTTSVTKVANFLIVMFIISKLPPRYEYLINQYTQYTLEEVDTANLDVLQSEIVNIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQQQQQQRPSGSSSGANGASGSNGNNKGKGKGKGKGKANFRRGSRAGKFEQAKRQGQAHLVHDDMSPMMHTVTVVDTPAAVDTRKPFFMETEKPFDAFFTGTKRAIKLARDIGTRPSGETVAILEDVVMSHPDPPSFTPLTPAPRSKRTLTERIYWDNLQSSSDGWGDAGNWNGWNGEYPESQTGSDADMACAQGEDAIWNEDTLVNTSELGSVFGTTTTESGAKVSQDIRTPVPLIDRIAADPAAEMTECAIYLGERFQNPEDPLHIYGEPLRTALNTVAPTGTCGTLSLVQRLAAVRSEMPNGSQPAPPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGRDGTTLQGSNSEFNARTPEHVSKPIRNQRPRVHVDSAIDRRDESTYVTRRGHRIVRNSKSTTFYPRHGYRQCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGQ7</accession>
    <name>A0A8H5CGQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGQ7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5341436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="307" mass="33069" checksum="D18EAA14A9AD3377" modified="2022-01-19" version="1">MGPACPQQAITLPLPDGIAADIVDVLIKTLYGVIFPDDEDCLTINVVRPAGISLDAKLPVVAWIFGGGFELGSPQMYDGATIVSRSIKLNEPVIYVSMSYRVTAFGFLASQEVKDAGVGKLGLQDQRRCERYSAGASFSIIGNIDIDIGAFGGDPEKVTIWGESAGAISVALHMLNNGGDTEGLFRAGFMQSGSPIPVGDITNGQKCTYYDALVDQTGCLGSEDTLQCLREVPYDQLKDAVNNSPNIFSYQSLNLAWLPRADGVFLSDNPQNWFNKARLQRFPSLLFPKGDCDDEGTLFSFSTLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGR8</accession>
    <name>A0A8H5CGR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGR8"/>
    <dbReference type="OrthoDB" id="3353107at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="253"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="64569" checksum="04C0B2E7AD64D604" modified="2022-01-19" version="1">MRQLELMCYANVHADTSCLRSLILERDVNHALLIQHSHSGRLQHVRGQCLDLLTTAREYLLMGPVQHRQDVTLSDFEALTSNVQRMLASVDQAITTSREVQDAPAMSLGDSFIPTGRQGRPSIAIDAGQLANLAINRTTRVDLATLFHCSSRTIRRRLLEYGFSAPGPPVYVDEENQQGEMICTYHPGRSADLSDITNDELDEPSFGRRMIDGFLLEAGFRVPHQQILDAYNRVIGPAVRPFGPTRLSRREYNVPGPNSLWHQDGQHGLIHWGIIFHGFIDGYARFVLGIWASNNNRAATVGELFQDITGVFGYPSWVRGDFGTENLIVAAEMERVRGLGRGSYIWGKSVHNIRIEHLWLDLTQGLGKKWKLFFLNLELHHNLDRNDGGHIWLLHHLFLNVINKELDLWIGAWNNHTLSSRTERHTTPKVMYVQGSAINGYQSVHVDPVTGETSAYIPLDDPALSDDQTAAYGVDWDDALDTRLRNHHDEHNTHQADATEPDVYVSNVPDQLSQVEVLEPNCPFSSNTDIQELDEFLDTLPHRQECDEVSHTELWRDALEKAVEILGRQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHQ0</accession>
    <name>A0A8H5CHQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000168">
        <property type="protein sequence ID" value="KAF5341296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHQ0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034393457" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="161" mass="15108" checksum="1431F61CD1A6B1A3" modified="2022-01-19" version="1">MFSAKVATLLGVAILAVNAQPLSSVANTVVPSSSAATTEAIPSSSQAPAETTFSSSAATTIATFSSSAATTAVFTSSSVASGNGTNTGYSSGSANQASATGSGASNGNSTGSATNTASNGNITSAESNSSDNTNGAAFFGYGPGMALVIATSLGASALGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CID6</accession>
    <name>A0A8H5CID6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="9" type="ORF">D9758_014070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CID6"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5341581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="288" mass="32483" checksum="55EC417E7EA7F395" modified="2022-01-19" version="1">MSTSVLRTRCLASHRASLPLLNPLQAHIVSNKKRSINTQPAYPGHIPLTAFQNAFLAVGSAVMSLADPYRADMVAALGETTAGPALPRLRDIMLQSPEGTRILRERPRINTSTVDMQALARLPEGTFGRMYITWLERTGVTPDSRDPVHYIDDPELAYVMQRYRECHDFYHCINNFSVNVESELAIKYFEFANLGLPLAALSALFGPLRLNQKKRQRLFSEYVPWALKCGSTARCLITVYWEKRWEQDVVEMKKELGLLDSPARWPKPKSPQPVDLQASSAENVLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK42</accession>
    <name>A0A8H5CK42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK42"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="249" mass="26644" checksum="669D27287E334DDC" modified="2022-01-19" version="1">MDGCPSLLVFGLVSPNPGSDAWVGGVEYVAGDIVDEAKLLEVFRTTLSITLLLQSMDSQVKYTIESMNAETGAVLSACRAVGVVELVYALSTGVVWTGADIVGASEDDLPIPSKGYDAYHHTKGLGEKIVLGHDGVDGLQVVVPRPCGMTGACDKQLIVKLTKVLKDGQQNIQIGDNTSLVDYLYVSNAARAHTLAANRLFSDPDTVAGQVFFVTNGSPLPPWTFNRLIWKELSRGNEASDDGKEQEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLL8</accession>
    <name>A0A8H5CLL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLL8"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13885" checksum="262E6E2F0530E672" modified="2022-01-19" version="1">MPIRLLCFIKRLPGVSFEQFDYHWKNTHGRLVATLKPIVEGRIKYVQLHTIPQSTELLESATLPVMAYDGIAEFHAETVEEVLQMFGSQEYQEKVAFDEATLGFDRVAVQVLAGEDHIPEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CML1</accession>
    <name>A0A8H5CML1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CML1"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="327" mass="36679" checksum="59E4AD16CA3BE0D8" modified="2022-01-19" version="1">MSSSHICPVNIPDRNGLRGWLIAAAAAPAAVTTRKAAMRFLTGPKGLATSIIHECNDFGLQGLSYCHEKITEYRLKKDDLASLICDCKMWQLICVDPEHLATPEWRKILDHKTFIKNLILFCSIGTIARGFIGEQTSLIGLSATCAPGAHTIDICNSLGLYGDSYHLVRRSNERENMFLTVESLERSKGVSKYARILEYLQSGRKAVIHVNTIPEAYDIYEFLWNHVPPGTSPLHRMQMYHALCTDKYNCETFERIDNDPRLQVVIATVAFTQGINRKKILDSISYNFPLTLDEYWQAKGRAGRNPDVICRGIALVPSSVTKEAKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN33</accession>
    <name>A0A8H5CN33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN33"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="93" mass="10754" checksum="DCB9936616B7243B" modified="2022-01-19" version="1">MLDLLRRAAYFRQNLVVVNRSRRALLGVRREGGRGVMLKPALKSTNTLTSFGRFSSKRPPLLHRDVDQVVRRQWYSQHQIENNPPSLRISPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNP4</accession>
    <name>A0A8H5CNP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNP4"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="23"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="645" mass="74091" checksum="51562CE12DE5EC7B" modified="2022-01-19" version="1">MTSSTGDDHTEHKAWWKSAIIYQIYPTSFFDSNGDGIGDLNGIASKLDYIKDLGVTVIWLSPIYKSPLADMGYDIADYRQIDPRYGTLEDWDRLLKGVHEREMKLMMDLVVNHTSDEHEWFISSSSSKSSPKRGWYIWRPPRTDNKTGVPNNWKSMFEGSVWQYHQETEEYYLHLWDKKQPDLNWENEDVREAVWDVMKFWLDRGCDGFRMDVINVISKTPGLPDAPITDPGEEYQPGTNDSPLSPSLSYPYSSRILLLYLLMNSPRVHEFLREMHTKVLSHYPTITVGETPFTHDPNVLAEYTLPKNNELMMVFPFELMHVDTPLAEGKPQGQATGNKGEGEVVAERAELMYREWKLDELKKIVEKWQLLKMREGYWSGVYIENHDQARSVSRFGNDSSDELQVHSAKGLAVWHVSMRGTCYVYQGQELGLKNAPRSWGIENFLDVASRNWYDKILEQRRKSTGEANPNMDDIMEGIHMKARDHARMPMPVSVLWSSSPNAGFTTGTPWMKVNDDYERWNAASQVGNDDSVLAFWKKALRVRKEYEVLVYGNFTLLAPTHQQLFAYTRKMRNGTVGLVVMNYSKEEVVVDVPKDLTGLQEGGEGYNELGLRCVLSNAGGDSEGESLKEKMVLKPYDARLYISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPF5</accession>
    <name>A0A8H5CPF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_011993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="EMBL" id="JAACJM010000111">
        <property type="protein sequence ID" value="KAF5345529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPF5"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5345529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="19345" checksum="BA79660D8242024E" modified="2022-01-19" version="1">MLIAVGHGWHALLGPFICQKEAFCKVLCVDFVDFRGLLFWLITRYLRVRPKCASPKSMSMNAVTIERIFEGDGRNYPESGDIVSIHYVGKLNDGSTFDSTYDRGRPFVVEIGIGKVIQGWDNGVPQLSKGEKVMMTVPPELAYGERGVPPIIPPNSTLKFEMELIDIVRPVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPP5</accession>
    <name>A0A8H5CPP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPP5"/>
    <dbReference type="OrthoDB" id="621413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="600"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="99643" checksum="6B353CD3A8E8EE94" modified="2022-01-19" version="1">MEQTDNGPDQTGTGNQANILSGAHDFNIMGSTITTIGRDAHYTYKTYLPESRPKELTADDLLLQKPPAPDVFTGRSHLVEEAVKLLCEANQVHIAILGTGGIGKTSVALHIMENAMIKKKFVRRGYFIPCEILPDATKLIQGLVQAIGLQPIQGKGSYELLLDYLEGCQKILLILDNFETPWNGKDQTKVKNFMNTICSLKSASVIVTMRGTDGPGQIKWGKLGGQSGLPPLELGPAKEAFCSLSSDGNYAIREDDPMLEKLLIQMDGMPLAIVLIAQHAKELPLKNLMEMWNIQKTAVLKKIGEQDNRLTSVEMSIELTLNIIKEKLSRTGLDLLRLVAFLPSGIPDWLENVPKMLGSFPDTTMQVLTLKKSCMIYEGNAETLKMLTPIAEYVLKVSKITEDHEKQIWEFYESFIDTLFENHIDADIKLGLHIANIFKILHIQIEKSFETSHMNVLNQLCDHSQYFPGLVPLVEKYLGWQSQMSLGSQTELMFLQEGMLTFMGEYEKSIAIINNVEKLHRHQINHGTSDLEVITSSSSISVNYTMEQTQAYCYQRLGMMSYCQNDYKNSQCKIQQAMDLYEKIGNVKGAAQCLQHLGDISKMLGQYEEAKVMLEQAKKEFEEIGDRLGAAQCLHRLGNISYMLSQYEEAKVMLEQAKKEFEEIGERLGAAQCLQSLGNISYMLDQYEEAKVMLEQAKKQFEEIGERLGAAQCLRSLGDIRKMLGQYEEAKVMLEQAKKQFEEIGDRLGVAQCLRSLGDIRRMLGQYEEAKVILQQVKDQFEEIGSRVGVANCLHSLGEIGYEEECFIEARLNVEKAKEYYEAMGMLNQVAECIHILDQIQEASAVHTQPHSIEVENLQETNLPLAVEGQGDSADVKSQESCGCCQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPV7</accession>
    <name>A0A8H5CPV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011905</name>
        <name evidence="3" type="ORF">D9758_013456</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPV7"/>
    <dbReference type="OrthoDB" id="3122067at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="476" mass="52638" checksum="328C1B5F8BDD0A93" modified="2022-01-19" version="1">MASSLLTSSLPEPSNFIDTLCGNLSLSESQNLDLQAVAQIGQGLERGSLLLHLVTQANIFHLQNSVNKLLAQDTSTASVLQDFKNQVTDKWALNEDDKVVVLKVVKDVLMDVNRASFSNAKDEVYTKLDTGKAAHRLTHAFKTPARIKTLKSHIRQTTNNMKGSLRRMALETAAGDNAKDLYGAVRKIESSLKMSFGDTQRVRITARVSLWRRYVRETNRRPTKRTNSGTEKEDSQTETFWDGFDEWLKKVRAEKNLGDDFGSEAWRKYLDETRILDANASKASIAAPVPQPSMPMLQGIESDTPTSRTPSNLTSPEISQHTSSLQGSHPRLSLSTSSFSASPSTSQSSLVLSSPMRSSPVLSSPTPSHLHRNSRPMSPLPFRAQSRNSTSHFHLTPLQNFNPDSSASHYTTPSRNGMSQPYDSIARVYQAPEPGLTHDGVSRFSDMEAWGHPPSSSSVDRHAASRAAQRPKPWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRT3</accession>
    <name>A0A8H5CRT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Possible tRNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRT3"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Possible tRNA binding" evidence="1">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="152" mass="17320" checksum="BE28437D42885362" modified="2022-01-19" version="1">MIKETPELDYFNVAYEGFVETESLGLPFKQRCANRMKQNRLPHLPPLLPKIQRIWERLLGRWMRRGKEDGGKVDTGKNVNLSAVQSAILLGMGLQRKNMEEQEIELSLPVNQILALFIKIIWKISKRLLDIQKEGIAGSGCGRIADTEDSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTS5</accession>
    <name>A0A8H5CTS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTS5"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="382"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="644" mass="70851" checksum="D299E2DC0DD0A7C4" modified="2022-01-19" version="1">MLLQRHGRSKKLANSACWTTSWPRFNLTGSSHCYQTGTQLLHSLLLVSLTLLLSSATQAVAVQFPQNFTPSTYPLAVKSTYLNAWISTQFNASDSSTSTLTHEAPKPNFGLDLGWCGMMRVDGEAWQWLGPISPNNVSTVKSTSIQGSIFTPTKIIFQMLAGPVTLNVTFLTPIETEDLTRQSLPFIYISLDVQSSDGQSHDVQVYSDITAEWVSGDRANTTVQWNTTFTSSSMFHRSFPQNPEPFNESNFQPQDGTVYYAMQQVQGLTWKTGEADVLRAQFLESGSLDNGEDTNFRTINSSFPAFAISVNLGNIQSTSQPIVESKCEDPISTQTLGFSSQRIEDVIDFFISDYDAAVQRSDNLDVKVREDVAASVSAGNEDEYFSLVSLSTRQLLANFELTFGTSSQDDGGVDIKAFARNTGVSALANNVPTLWGSFPVFLYLNATWAKYLLDSTLQYQHSFVYGKNYAAPDLGGNYPTEVQGNNKADETNSVKDTGLMLIMTLAYTKSAGDIEFLRKYYDTLKSWADYLTHKSFPPVNQQSGDLIGFASDDNSIIAIKGIIGIGAMAQIANAVGKLNDASVYSEASSSLAQQWQEQAVKSDHISLNYNNPRSFALVYDLYADLLLGTGLVNNSVSYYEAEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZ27</accession>
    <name>A0A8H5CZ27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZ27"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="708" mass="78003" checksum="29E133831F78B9E8" modified="2022-01-19" version="1">MHASQQPFGECIMMEVGDAMTVMTEEGGDHGDVDGYWNSDENLLRVSQWRLAVPDDAENPETNSDRDSRMDVDSGKKSDVETGSLDTDSQHQEVELSTRNFPQAPQHYNLTAGEGFNSLDNYATVVPSSSFYDPSPYVGNSFSQVRDAALGLPTGNEFSVSSSSYGSSGSSCSAGYANFRINLSDMLGCQGSGGPEEPDFSDSSSSFFVHSSGCDSSSVYRQAGPWTFSDSDSTGGYVVEERQECWQDKVAQESRVASNIDASMTDDSSSVRVNVLPEDPSMNPTAPVHFQSSIDSDAMLLKSLGSLPPALHWQPYRQYLNSSIGDENSCYSLYPSFPSPGVHEQLPSLPFSTAGSPPCGPATAPFPQEEPPPSMHWQYQDDRQYSNNLIDDENQSYSQRPPSPGVYEQLSSPPFSAASPPPRSPSPSSNISFSQEEPPPPMLRDPVPHQAAISPFSRFQYPLPLTAGQTLTQNTGSPAFLPSSRHDKISTRIQEDPAMFWGCNLWPFYTGIPILVVTDPDGNFSVPEFYEYNEQASSNTESDEDIEILSNDLDGQSSSTSGLYQDSSALPDSTDFEMVYDSEPLPLQHSYNCHVCNVRSFSRKEALERHLNTAHKAKNFKTQSRSKSAARSNRSQRMCKSNLLALERDHGNIARHQRTRGCMQERVELLERAYDLVNELSATLYQDNIESGLFSDPHSLDFFSLDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EXK2</accession>
    <name>A0A8H5EXK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_019134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000491">
        <property type="protein sequence ID" value="KAF5315987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EXK2"/>
    <dbReference type="OrthoDB" id="3267748at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5315987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="21715" checksum="F1CC0DCA69F48B55" modified="2022-01-19" version="1">MKYYQKGLPRGLVNWISYLSTQPKSLAALQKAAVKQHMIWLERQEEKTLWSKPRREEGQPGRRSQGTGSGRTRSMEVNAFQDNAPGASSITKYPPKLTPQERDKMRKEGRCFRCRGQGHMGNDCPTFPSTPPTTPNNTTWRPSIKTAAVTETSDPKVNTTTDNISELTTRIGALLREEKEGLLRKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4Q3</accession>
    <name>A0A8H5F4Q3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000396">
        <property type="protein sequence ID" value="KAF5323203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4Q3"/>
    <dbReference type="OrthoDB" id="3263941at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58293" checksum="6040FD0271297285" modified="2022-01-19" version="1">MWSSRAAKVALKVQLKSIHARVTRNRLTTVFFLFGFFHCIAQGLIQSFLFTIDSQYSSFLDHIMNVTEVPKQNHTDLLGTSGDFRLQECNFIPHRPENCSYIFDTGSVKKIAAHVPTIDISQVTLSVIPSSPPNAPNVSLKSVDTAPDPNATAPGTVNIPLNDQCLGTLLYAQQHLQNSKREDIVFLALQFWIFGISVIAMCYDSVPHVLAVLGARILLTAWAIYALWRTEYQQSIFKQMIEDPGTPCAVKIFPTYSSTRIHYEIPDLVLNCTALGIALYLSWSLLRVFNSEKVQRIGAPEHINRIYKYFLAVQVCLQLEVFVLMAWMGLWLDQLFNSYIHVISTGQKLYEGLFIVYTVALVPWMAAGWIGIRFEKRNLTAAFIFFSIIFFSLPAAMFRASTYRWTYYAWPCWGSFTTASLILLIATAVLSILCFKNFNKGLSQYLHAESALASSNFVPEVFEHDVEKAADKSIEKHDRLSFDQPLPTYYLPNLHANPSFSDRSSYTSNTTDTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEE9</accession>
    <name>A0A8H5FEE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000271">
        <property type="protein sequence ID" value="KAF5334075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEE9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="307" mass="33586" checksum="B416600C33A97134" modified="2022-01-19" version="1">MIILVYSTRSAPPLNTSSMSNYHQESPLTDVEGLHFRYPTLSPTPPDGSRHHGAVAFQRLPAVSVPSSVLASTSSRERSPSRTATSTLPKPGSAKYNAMSGVTFRPGSPVKTDRQFSFGSHDEEGDIADNEVTDRTDTKRSRKPTKKMLETVVIEISTESESEQVRKKIQVKEKVMPKSSGKTRGSTKSSYDLDLSTHPRSNDTVDPAPSGPKHQRSATKRKADITGVSELPQRRSTRLRLAEDSKVNDPSETLEYVDTPERQLSPSLQSPKGPTASNPAQGSTNEDHTLESVADGSIEYFFSSAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJ81</accession>
    <name>A0A8H5FJ81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_012079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJ81"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5338801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="23218" checksum="CC05C1541B7D654D" modified="2022-01-19" version="1">MDNSFQGQPSTPTRRPDLKRKLVVVGDGGCGKTCLLIVYAENRFPEAYIPTVFENYVTQVQFDGKEIELALWDTAGQEEYDRLRPLSYPESNVILIVFSIDFPTSLGNVQDKWYPEVAHFCEGTPLILVGTKIDLRADEQTKRMLGAQGQITVTPAQGGAVAKEIGAKYIECSAKTGRGVQDVFNLALKESMKGRWNKIVKERRCVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FK19</accession>
    <name>A0A8H5FK19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_013320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FK19"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5339253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="556" mass="62475" checksum="F4F1F22485206B32" modified="2022-01-19" version="1">MVDSPVVDEKRDATPPTSEVKDRTDLEFADDTNEEPSKWTTSRNELWAYYLFYIGNNGLSGFNFGPSQFQNLLFLAGYDPSAPPFTVPCGDGGCVLPYLGRVRDINSIVLLTNGISFAIQAVLLLFVGAWADYGRWRPNITIFFTILAIAVSFAWLGVDDPSQWRAGIALYILGLKESLTHVKEGRKTLAEHAQLTSLSRNRISNMSFTICSAGEIVILAIMVGILKGLHSDESTENNTKAFSVLIAFAGGVWLLCALPWFFLEKRRPGLSLPPGTSLLTIGFKQTYVALRECMRLTQTFLYLLFYFLMGDVLNTTVTVIATLQNSVVSYSTLQLTLLLIVGIATQMIGIYLFWLVQKKYKISTKAMLSFNVFWIIILTIWGLIGVHTDKFGFKHVWEIWLYQAYYGLMVCPWYAYSQTMISEVSPLPQMFLFFALFSVVGKTSAFIGPFVSSAIISAADNNDNMPFAFLFGLGVFSTIFLYFVDVDKSRIECEEFVKAEEARQLFDSEKTDAVVASAFTGDPELKMAAVLLYRRNRTVESGYRMIQLTIYEADEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQA4</accession>
    <name>A0A8H5FQA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_011593</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQA4"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5344892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="65331" checksum="C6C09BBC0E468FD3" modified="2022-01-19" version="1">MSPIACTLEFVNHHIVDNIQRLPTAVVGILAGIGVFTALVSYQLVLYPFFLSPLRKLPGPPLGPNLLIGRFGEIIRGEAGIPQREWVKKYGTPLRVVGPIGLQRLIFTSPEALQKILVSGWTANPRPKFMRDILGIVAGYGLLTVTGNEHRQMRKAMNPAFSIPALMAQVDMYHDAVDSLVDILNDKISTEEEKTGAGQGKVELMYEWMSKVTLDIICLSAFGYETDSLHNPHNELAEAYEELIKLQTGGNLSRFILIMSIPGVPRFFASEWAWKHRNMIGKLPTLRSAEILLDCMHRIKDVSTRILAQKLQEAGGLDSADTSTKKDIMSLLVRARKAEEEAREKEKAKLGMGVAAAGVESYRMSDKEMMDQVLTFLGAGHETTASGLAWTLWLLANDQESQQKLREEVSPLFEVSTTENGSKIRRGRPGYRELKDLLWLDAVVMESLRLYPPVPMTFRQAATNDYIDGIYVPKGTMFYIPIRVVNTLVDVWGEDAEEFRPSRWLPGHLPDKYNVNPSLSMMSFIAGPHACIGKTMSIMEMKAVLAPLIANFEFEPSYAGQNAMPTAAVTMKPADDMPLRVRRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQC0</accession>
    <name>A0A8H5FQC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQC0"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="63888" checksum="D21DFF888179F63E" modified="2022-01-19" version="1">MSAISLQGKIALVTGGGTGMGLMIAKELSTNGAEVYITGRRLQVLEKTASENALIPLQTDVSEKESISNAIKSIDQAEGKLDILVNNAGIIRTLLDVLKGRDSPKDAKVGETAFAQDTFEEWGRIFKTNTAAPYFVTMGFVTLLEKGARARNGTSSVINISSAGASIKLSPAGVNLLTQLLATQFALQNIPIRVNTISPGMFPSEGMDAAGLDINQIASQPALGIFSPAPLLRLGRPSEIGTAATFLASDSGEFVNGQNLGIDGGISRISGVLKAIEIYTALIPSSQLTRRLRPAEPPFFVFLLSADHGVCERFALPKVCPIEEAEHEAVRARIPEPFGPDDILWQRRVPYQSHPNYRGLGGAFQRFPRAPGAQFHERTHQNAPTRGDGGGSSPSDHGHPSRNSDTAPKNARGTPSSGKSTNRPMPNGSGPPDDDPLGSVPSILFRTPPVVGITGPIQSPPGHVRLPTDWLASLMIHHLVITSPNRAVTAPIRKMKMKIMTVILLKPQLMLKPCQGPEYLGKLVVHQPIKPSTKRSESDDPEPWGGSQWTSDAADEDYIELRGRMTGMRVVSDNESVSSYDTAPDLQPYFEQIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRU8</accession>
    <name>A0A8H5FRU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRU8"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17769">
        <property type="entry name" value="NP_TgUP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF14">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="341" mass="37491" checksum="30EC04247AB9B0F7" modified="2022-01-19" version="1">MKDLLTDANFPRTADLRVYHLGLRPGEVANRIVTVGSPSRAQMIASFLDERPKPFQLQSERGFLTITGRYQGTPISVISIGMGSPNMDFFVREARECLSGDMYIVRLGSCGCLIDAPVGTVVVPKACVAVVRNVDFDYADPTNCDEPAYRISKPVFGDSELHLQVTKALEEARPKDSSNMILSDVVNASADSFYSSQGRQTSFPDANENLIQHLLDTVKDLATLEMETHHLYHLAACWGRSSTAQTTQPPPLATGPVNPSTEDTPASQSTPIAQLARPDTSIKASAAQMVFASRTSRDFITPEQVKEMEHWTGKAILDALKCMNIPSERHHPEQGSVWERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FS09</accession>
    <name>A0A8H5FS09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FS09"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="354"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="820" mass="92396" checksum="D5AF5A46F86F6002" modified="2022-01-19" version="1">MLAMSVVEEKVSAWTFFILVWSAGNEILVATARCDSEIMLNNACSHCLKLGLPCTHTKAQQKRGPKSRIMIGGSQSVDTLVANITGGTPSQAFLIPDSKEEIRKILVKLATRIQELENDRELSEYSELHKSVSLASVQDTNRTQETINVPGDSLDHDDSVEDLSKELANFSFGAPSNTHFGESSNIMLMKTAMDHGKQLTGSILPDWNSIFAHVRRPRFWDTDPWPSWYLLARPELEPAYEFPDTDTLHQFMDLYFRHCEIDFPLLHRPSFENSISEGLHLRDAAFGAVVLAVCAIGAGILSASNIQREAGDRWIAQVRLSTFVFSSKLELYHLQLYCLMIYYLYSVSKGIDSAWLLAGIAIRRAQEKGAHRRYTVSTHLPTVEGELWKRAFWTLIVADVQLSTLFGRPRAISSQDFDLEPLIECDDEYWEPKDGSPAFVQPLGKPSKISYWNAYLKIMEIYGFAWLTIYSVRKADLSNKMGISDIEWYEKAVMETDSALNKWMDSIPQHLRWDSQPQDSVTFAHSTILYSTYYWIQIMVHKHFIPRPRTKDSSGILSFPSLAICTNAARSCLRVCEAYVKINTLYPAQLVLVISNAATVLALNLARSNQLKLKFNMVKEITDIYRCIDLLRLYERTQVKHHFVAHFMKLTLLQLDTCRATDDRTSDSINVILFVNRFPPRLHPSYNEGSPALSASASQSQVKTTQFLFNQFSAASDSSSAPAVTYGTPAESSSTTFRTQLPFYSSELGGLPIHPKLTSLSEPNAEHFDSHSPGFNHHSTQANFDVPSSPSPDMRQYFSLFDDTVGNMCDSFMGTQFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSK2</accession>
    <name>A0A8H5FSK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSK2"/>
    <dbReference type="OrthoDB" id="3255462at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034361853" evidence="1">
        <location>
            <begin position="18"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="461" mass="53307" checksum="1E3CB920771BE3DF" modified="2022-01-19" version="1">MQLKAFVLLAVALLSSAAPFAEDNTKRSPYGLDDVDKRVPHDYGLAKEEVVDRRVPHVYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHVYGLAKEEIVDRRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVDRRLPHKTVNRRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHVYGLAKEEVDRRVPHNYGLAKEEVVDRRVPHNYGLAKEEVVDRRVPHVYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHVYGLAKEEAVDRRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVDRRVPHVYGLAKEEVVDKRVPHVYGLAKEEVIDRRVPHDYGLAKEEVVERRVPHDYGLAKEEVVDRRVPHDYGLAKEEVVERRVPHDYGLAKEEVVERRVPHDYGLAKEETLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVZ3</accession>
    <name>A0A8H5FVZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVZ3"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="12069" checksum="454C9FA0DC149137" modified="2022-01-19" version="1">MSWTNQTVPVEASRSPTTHFDPKSLFRMTFHDRYGKMIGPVRELRDFVGGSNPSHASKTLEYNAEGPLPEPVVQAFDDCYFKIKARLVNYYHNPTWYDPEKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW34</accession>
    <name>A0A8H5FW34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW34"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5350862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19413" checksum="D3A822FF98F98FF0" modified="2022-01-19" version="1">MDDLDLAEAMIHDDVALTLQCILSAFWTNAHRFSGRDAARALNRPVHVRITGTVNTDRSRTIAKHTDIVSPSSSFHQLTMPSDRPHPFAPHPKPSNSLGVLRVLSPRAGVRVSPICLGGGNIGDRWPGSSMTKEKSFEYLDAFFERGGNFIDTANNYQEEASEEYIGEWMESRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G174</accession>
    <name>A0A8H5G174_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G174"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5356430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="68039" checksum="72378A2AD76C49CC" modified="2022-01-19" version="1">MASTPLQNGSVEPIEPSNIPAVVGINFGNSFASIAVFTKEGLAECIANEDGERQIACAVSFFGEEMYIGNQAKNQLVKNSKNTIVGFRNLLGKKFSEIPQSQSTSSAPVIQHPDIPDEPAYKVEILQPAPSPLPKTASNTPAASSAPTPRSEPIPGERILSVSEVTTIFLKSLIQSAQDFLGKTVQGAVITIPSTFTDAQKDALEKAALDAGVKVYQLLEEPAAAASTTTTDIWSPNLSTDRTQLVVDIGASSLHLSLLSLRQGLAHILASHSSENSSVAGNAIDSKLITFFANEFTKKTKTPLTVGSPNGAPSVADARAEAKLRLAVEHTKRTLSASPGAATCSVESLKDGMDFTGSINRMRFDMLIRPIYQSIADAITELLSSAGVDAHQVDEIVYVGGTTCLPGLDEHLCLTGGFNENIDTPFSMGTVVGGGVGDPTTVLARGCALQAALIESLSADEASAELRKAFERNTDLTEVTVTSKTLGLIFPDESGNELGGTWVPVVLKETALPARRSVTFDVELSDESKRFAFELWEVSEGIRIEKVKPPKVELSDDEGADEEEEEEEEVEVKHKTVTKETLLGAAEGKALLGIKAKGPSKETGKWTSTMEATFVVTATGALNVSVKEVGKDGVSLNISVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1C5</accession>
    <name>A0A8H5G1C5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1C5"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="576" mass="65138" checksum="F2F98CF954FE853F" modified="2022-01-19" version="1">MSNGISICESYSVPAEAKNLLENELINNKLHSSAPPEIHDAYKYIEFKGTDFPSIPINWRFAESMAALRGFEGAMLNVLLHKKYGIPYQRVVVDTDHASLIFMGFRFSEVNPDTEKLTPYDPEFNQKYFPRLIKSPAFYSPVGQKCSNIYRTKDGRYFHTHASLDPIPTMKALGIDPDMKMRIGTNPCDIYAEKVATYNASDLDKYLNDEHRQAATVCLTTEEFLASPHGKANAHVGLFEIHHIPNPKQKPTWWTPVEGKTTPERPLFGLKVIDLTRIIAAPAIGRTLAEQGASVLRITSPNVPDFAELSFELGWGKWNAHLDLKKEEDRQRLRELILDSDVVIDGYRPGVMEKWGFGKEAILKMFEEKEKGIIYAHENCYGWNGPLSYRSGWQQISDAICGVSTEFGRAMGLDEAVTPVFPNSDYSTGVSGAIGILQALIERSEKGGSYVLDVALNYYSQWLINSCKTYHPEVWSKLWSNFNNFVFHHDDSMLVTLPAYFKMLTENPHSSKALLNPEFWEVRKSEGMGKGVTVRAVRPALTFPEGLVKPGFQVGTRRNGRDKPRWPEDLETQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1D3</accession>
    <name>A0A8H5G1D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1D3"/>
    <dbReference type="OrthoDB" id="2789810at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45915" checksum="41077D48BD6AE1FD" modified="2022-01-19" version="1">MYSRRVSRVSHPATTMSCFPAEIIDHIVDFLDDDAFTLCNISIVSSQWLPSGRARLFRAAKVNQETFGRFLDLLAHPLSTFSMSVKHINIDGQNQPYPESLRQDVSKIGERCPNIVSVYLSNLTFTDIEPGHHSSLLNAFPNVTILCLDGITFISVSQMMSIFCGIPLLREGSLINLIWDDPSTNEEEGLYSYKIPSSLRELRLEDCYKRDVLKCFLRHDPFPPITTLDVGVLSPTDTQVLGEYLMRLGSSLNHFSLGFSSFDAGGDAEDFYHNCDLSHNVSLQSITFHRLIDYWKYRLTSPVPWNLKTLSQIQSDVFQEISFSIYLDYLIELLAFPIDFDWGEMDRFFTEGNLPHLRVVRFTLFIGHQVDLHEATRTLGVYLPLTMEKRILRVEIHRSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5C6</accession>
    <name>A0A8H5G5C6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5C6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034251889" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5358649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="714" mass="78177" checksum="7E9E21763E52E697" modified="2022-01-19" version="1">MFQRHRCTQTLITVALVTGALTTIQAQTLPSTFPHNYTGIPSGGYGPDWQDYFRVTGNLANVTRKSTLTSYAGNIGVNRPDHPNNTLWFWAFERSSEGGKGSLSAAAGERQDEPWVIWLNGGPGASSSLGLLTENGPLQVTGDFNIVTNNFSWDHLADVFWVDQPVGTGFSTSDASGYVPGEDQVGRDFVGFLSNLVRVFPSLATRPFYLTGESYAGTYIPYITKELFSTQFPPVNLKKISIGDGTIGAFPLYEELSTVNTLEAWPQIINFDPDVLQYFRVQHHLCGYDVNLTYPQQGIIPSLLDPFMTTSVQNSLAIQQRFHSGFQKGATLSFANRLATPSSRRKRSLDPRERGMDLLLTRLHERMFERGLHRLETREAKEIREVKREEWKRDLSGRANGTLDPFYGCFLFEEMVDYALNFTFPWNEGDFDVYDIPDALDPEVPADPSVFLNDNTTRRALHAPDVEWQPFFEGVFGGSNVGNPFGDPSDPPMAFMSELLANASTRGVGVVIYEGNNDALVAHRQAEVTIQNITWGGIQGFTRKPATPWSDDSGTFTGIVHQERNLTYAFFPNAGHLVPRTQPEAALVFLREFILGNNKTGLVEDSGNVVGGEVASLSADIFPGINSIFYGTGPQATTTGTLTFPSETWASWSSFLATATNALPPFSGDSGGNGGGNGGINDGGDTNGGHMLHASMGLSVMLAVSLGWGMVWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5G3</accession>
    <name>A0A8H5G5G3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2687798at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
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            <begin position="138"/>
            <end position="153"/>
        </location>
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            <begin position="154"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="191"/>
            <end position="211"/>
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            <begin position="218"/>
            <end position="235"/>
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            <begin position="269"/>
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            <begin position="303"/>
            <end position="327"/>
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            <begin position="333"/>
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            <begin position="380"/>
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            <begin position="390"/>
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            <begin position="449"/>
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            <begin position="484"/>
            <end position="494"/>
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            <begin position="506"/>
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            <begin position="622"/>
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            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
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        <location>
            <begin position="882"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="898"/>
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        <location>
            <begin position="926"/>
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        <location>
            <begin position="951"/>
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            <begin position="976"/>
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            <begin position="1010"/>
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            <begin position="1272"/>
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        <location>
            <begin position="1321"/>
            <end position="1334"/>
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        <location>
            <begin position="1342"/>
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            <begin position="1477"/>
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        <location>
            <begin position="1496"/>
            <end position="1507"/>
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        <location>
            <begin position="1512"/>
            <end position="1522"/>
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    </feature>
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            <begin position="1540"/>
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        <location>
            <begin position="1555"/>
            <end position="1574"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1596" mass="158708" checksum="2AECC30BEB1B2998" modified="2022-01-19" version="1">MLKEMRSIYTAPPHQDDQIRIFDADAPLNHRARDATSVALEFREDGISSKDGDTPPSFMTRRSILARGGIDAGSTAPAHNQNGPSSNSNNRPSQGSPSNTDSKGNAAGGGSNSQSENNQAPQASNGQDHSTPSVNADGNGASGKSPSSPASGNQQPSAKTQGNSNVPSQSGKSAVNGDNHPPASGVQTSDNNNNHGSSNSNSNGQNAQSNAGPGSGNPAANKNTPDNQHSSTANDVQAPKGQDHSTPSGNANGNGAGGKSPSPPASGNQQPSDQTQGNSNVSPQSGKSAANGDSPPASGVQTSDNQNNNHGSSNSNSNGQNTQSNAGPGSGNPAASKNNPDNQHSSTANDVQDPNGQDHSTPSGNANGNGAGGKSPSPPGSGNQQPSGQTKGNSNVSSQSGKSAANGDNRPPGSGVQTSDNHGGSNGSSNGQNAQSNSGPGSGNPVANKNSPDNQHPSTANGANTPGAAQKSDDSQGNGILSGILGGNGNSGGGKSKDITSGAQTSDNHGGSNGNSNDQNAQSNSGPGSGSPVANKNNPDNQHPSTANGPNISGAAQKSNDKGNGIVSGILGGNSGSPSNSKSNKGPQGIGSGQPKSASAPASHGPISQPPSASGKDSGKDGNNGGGGGGGILSGIFGGNSGNPSNSKSNKGPQGIGGVGGKGSGPLSGIIPGGGGDSHKNPSQTQNHGGKDKGLGGIVQGVGDVIHDVGNSVGKVAQGVGDVIHDVGNGVGKVAQGIGKAAQSIGQGLGSDGHNNHGSGGGGSGGGIPGIPGIPSLPIGGGGSGGGGSTSQAGGKGGAGGGNGGGNNGGNPDGSGSPQNPGPSNGQGGAGDGNGGGNNDGNHDGSGFPQNPGPSNGQGGAGGGNDGDNNGGNHNGSGSPQNPSPSNGPPPQHPESGGNSGNNPGKGGPPDTHPPPPPNTGGSHNPPQPQPPPPPESAPVPPPNTGGSHNPPQPQPPPPPESAPVPPPNTGGSHNPPQPQPPPPPESAPVPPPNTGSGGNQPPPSNNNGSNGGAAGGGQESNPNGGTIIPLSTSSAQIRNAITSSTPSETLTTEIISYTTSTPVLTTTITTSTNGRNTTRISTSFSSFVTTSAIITPVSAPTSSGNLNSGSHSSSNAAMIGGIVGGISFLILLGTFLCFWHRRRQQAATRPQTIFSKQYSHSEKDIEANPVYTSEKPVPDSPHSTPTPSITDFDSDQSSVRSAVSGNLFQRFSALLASTRTIKRTATFRELGGSPSSAITPPRPSSSRPPSTPSSVAESRISSLVLPRTRDSSTSSSSSLSYMSTPAASTIRCSIAESAFEIVNPFADPVDHGGTGDLDSSAVTVENGVNNSNPFADPVPEDSQTTADGKNLPSRLSSSTSVAGEFEHGLACRTFCFVAYTSIYLLLGIRRLAIDLGWSGKGAAELDLAQPMPNFSYTVTSDVSQFSPKSLRLPRLELFNFHIHYHRVNKMIPRRTIQAISRSRAYPRPIHTSSVLRKPETKVNSDSYQKEDLGASNLDSSSDMISSTKQVHRVDPTSDKVHTANGPATGQWSRAGAQTEEYRHVERPDGSPYKEPGKEERYGGREPYASEKGKKTSRPGEGPEGESAGGRKPEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G621</accession>
    <name>A0A8H5G621_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G621"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
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        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
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            <begin position="1"/>
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    </feature>
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            <begin position="258"/>
            <end position="267"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF5359009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="29425" checksum="4ECD6DA8BC66DBB3" modified="2022-01-19" version="1">MLVPPKGSAKKPAAAPFASKSSKAKKNPLFEASPRNFGIGGDIQPQTDLTRFVKWPEYVRLQRQKVILNQRLKVPPSIAQFSHTLDKNTATQLFKLLNKYRPETKVEKKERLNATAAAAAEGKDKTDTKKPLFVKYGLNHIVALVEAKKASLVVIAHDVEPIELVVYLPALCRKMGVPYVIVKGKARLGTVVHKKTAAVVALEEVKSEDQRELATLVSAAKANFSDKYEEHRRQWGGGVRGNKSTQMLRKRAKAAGQNPGSANITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G657</accession>
    <name>A0A8H5G657_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G657"/>
    <dbReference type="OrthoDB" id="124582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5359066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="930" mass="104257" checksum="6E1EB979C06E1864" modified="2022-01-19" version="1">MGGYTPCKPIGYRNRSSSPTEVESGNTMDTEDNSFQNALQIAFESVKDFHGSWTFSLKPVTDARKVPDPALTVDGVGCLRLPLDEAQAQVLIEKAQQASITSNGPVKIDASELHFLNSEFNSWLRKTLDPKVAAAFGLQPSDMIMQLSKLLLFEGNGSHLQATQTTENAPGMFATVLVSLPCEHTGGELVLTHSNSTTTYESSTTSLDVIDVTGWYTGVCYEVKPVTSGYRLCLCFNLFHAIDSASGIPRLDSAVSSDEGLRAVLTKWKDNRNLLASKSGDTVAYVLNGGQYGSNYDKLRSGIRFLDDEDARLVSNVRNVAEGLGFFLGIAMFELNRGGNIDSDDSWSGDDLCYGFVTEDNRYRLMTEVFETNSQIWAFHDLDGVKMEHMELECSSLILKNDFFDKNVPTFQGYAVVDRSYEQWEQSYNLTALIIIHGDKPYCTRLRAFQMIQRLEKASIAASEPSSAEKESVHELLKSLPRLQKEQVYQLMHCACLWKDNDLLDGVMKGVDLQLGEVSRYFEVWDVFGWEIFSERIQPRLRQMKGLSTKYEFLEALSTHPSSVQEAGIVREWRDKVFNAILRELQEVNKLDVPIMFSLIEKHGMKWFMEQVFPNLPKEIEGSTLDLHAFWKEFVKGLLDKYAGKEPTEYSSAVGTATFPPTTPLLKSLKILVELCIDTGPAFRTSLWNTSDVAETVTLSVRAHHPEVCAELFKNLLERDTRLVYTLENHYGSLIKRLDQVEGLDIFAMNPFSQFIKTVITEYMRRVLGPKPAGIHDLPTQPFGCGSCEECSRVDEFLKDQSANRRSLDMHQNSEIIQHLSKYLDDSTDRVSYKVASKSRRGKNGKVGQMDIVKKPKYKLASRWRDKVIKGKAFLERIGNANVIRVMGDDYDTVVVKALEGLAGAGTSAPVQGQRNASSLPAGKKRKAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G841</accession>
    <name>A0A8H5G841_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5359985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G841"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="453"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5359985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="834" mass="94905" checksum="C9F2EFF153AB7384" modified="2022-01-19" version="1">MRAASFAGVVPRTPPRSSPHAQTQVMSTPLARGSSSQVDLADNHKVADINTYLEEDIKDRVHLDLEIFLKLVLDFGDAERKKETKINNVMKNENFERVWNYYRGLCGLGSTTEKELYEPLLKVIETAMKRLFPNQQPFTHFNGGDKFILGSYARRKPDLPAVRRVFGLDRDTAKDTQVHWPMVEPFGELKLTPKQGGKRTGFALDWGDATPGETPQAVTAPATQNRYNLRSRSASGGSLPNAFPTQSHTRSLHPIPETSTHTESKNEEVEAGKKNKKKGNKGTKQKKKTLGDEMEPEEENLLTKPSDRRLHTLLQCAGYGLESLSSGLLRTHTVGFVMDGTFFQLCYYDRSKVVLSKPVDLSEPNSMFLFLATLYQLGSLPDEKQGIFPSKGDGKSLPTLEPSVNERYTRREGGNYTSGPITGESLLFPGGNAFSGCKMTVGKEVFHLGELVHRAHAIIGRGTTVVRVKWNDKDAIMKLSFCGAERTPEEELVKSARAKATEEGHDWALNHLPNILYSAEYNLAGLAEDRLATYFEQQRIPYERRVLRITVQDVLTPITDAVLEPKDYAQIFFDVLQIHRWLVDHAKILHRDISMTNIMFREKDGKIYGVLNDFDLSSRLPPESKASSRQRTGTKPYMSHELLNPSWVHGHRYRHDLESLFYVILIFCSDYGAKGEEDKLVKVMEPHFQKWFTGSFEDVRTGKISWLLDDKPLIQVTEFFRAFGLFYLDKLRNLVNKGHRAKNDYTSAWGEYKNSEKEHKEYGYPFTQVFTETFEWETLNDTVTYEKFRDVMKSFPVRTSSGKWQPFQLAMHYEDPLPLNPSDFGLPPDNDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8H4</accession>
    <name>A0A8H5G8H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8H4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="18644" checksum="AF70F5158B20B467" modified="2022-01-19" version="1">MGTGIQTPASTRSFSHLRPHSFHIFSTPVGFTCTSSKVLLVATSTSTSSISPTIPVPVPMLVHVDSHSFFFPSTLGLFAFFSFYFTWASSFFYPASFPSLFPSQQLQLSNSSVNNSPTKSPFTPRLAFTFAQSQHGHGTGADEPLEWEWIKRVDLEEVRRFTEREHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8I5</accession>
    <name>A0A8H5G8I5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011316</name>
        <name evidence="1" type="ORF">D9758_014397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8I5"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25277" checksum="6729F9AD174DAC88" modified="2022-01-19" version="1">MSANTVGPIALLPKEKTVVSRKFGPETGGDVVFRSSDKVLFHVHQKHLEVCAEGFPLAKHTTPSQNEIIPLSEKSSTLELLFQFILPQRFPELDKLDFEQLMELANASEKYVVYSGQSTCALYMRGFLASHPERILEYAATHHHYSIIYALAPRLVMKPLAELANILPHDIFVPWSIYCVNFHGLLHALGDGSAIYSICWANCTFIHTRFQKLFQNLDPFKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAB7</accession>
    <name>A0A8H5GAB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAB7"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5361309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76340" checksum="1E6723B7CA1EB1BC" modified="2022-01-19" version="1">MNSVVVQAGFAGLANHLLFHYFEPSPANTPLAAVFLVLQPLLLAVLPRHTFITPLSLSLPSFWSTLALTYTTFVLTLASSITLYRLSPFHPLANVPGPMVMKISKAYLLWISMRGERHLVFKKLHDRYGDVVRTGPNEISICQVQAMTQVLGSSGFQKGKAYAVRQSNKSIPQSLVVASSPSLHARKRVLWNHGMSMQALKDYEVVMLQKGKELVEVLRRCATGADKDVDLVKWINYFTFDFMSEMAFGGGSSMLKDGKDTHGMWDILEQHARIMDALAQVPWLSHFVYKVFDFPFAKVGARWAMARVKRGNSESVNANGDGSGDENGDKMRLKDLWWYLTNEDNQDQDSLTTTSTSTKSKSKQKPHLSLPEVASEGIVAILGGSDTTSSVLACLFWLLMIPDNRGWYERVREEIGRVYPKHYENYPKRQTDKEEEEEEEDWDWLEEFKDTKKRNELKVLGACINETLRLFPPTLTNGPREVTSVEEERVVAGYFLPKGTEIYVPPYVIHRNPAYFSDPDRFDPGRWLDPVRTREGEGERDGGSEGESESQGQNKRKGKLGSDIISPGLGTEGETRPEPEPELTTTATHPKHIHTPLAYIPFSYGPRNCVGRALARQELLIIAALLIREFEFEFPRANGESGGEGESGSDWKTWPDRLKDYWVTMRGELKVVVKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAM6</accession>
    <name>A0A8H5GAM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAM6"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="68" mass="7836" checksum="FB567F93BA737CE1" modified="2022-01-19" version="1">MANKFWLLKAEPDSRIVKGKDVKFSVDDFEQVQTSPWEGVRNYEARNLMKEMKTGEKVGSNFISTHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAQ3</accession>
    <name>A0A8H5GAQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAQ3"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17412" checksum="FCC4079312510161" modified="2022-01-19" version="1">MATTPTCIPSPQPSPHKRTLSLSTAKKFKLTAQLELIDNRCHSTSPKSLSGEGAPEGEGNPKELRTKFVGEVDLLESKEPLLQEIKCCFVLFPIQYPEMYKKAEASFWTAKEMDLSKDLHDWNNHTNDNKCHFISHVFTSFAASDSIINESLVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB55</accession>
    <name>A0A8H5GB55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="9">PARP</shortName>
            <ecNumber evidence="9">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_007389</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB55"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="13">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="11">
        <location>
            <begin position="395"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5361683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="635" mass="69507" checksum="FC0C6CF52EDE43D9" modified="2022-01-19" version="1">MPPRKKASIDTSAPTAPTRTSSRTAAKAAAAPSAASAKAPAQPKTKGKRARSGSDNEDDAPPPKPVSKKAKKTKAAEDDDEDATGKDDDKKDDKKIVTVLKRGAAPVDAALGKLVSSCLAYVLLGFLLTRHLSDTHQVYSNAEGVWDAMLNQTNVANNNNKFYVLQLLHPIGNDSNCVLYTRWGRVGENGQSQVKGPWPPAAAISEFKKLFKNKAGVNWEQRVGMVAKSGKYMWLERSFDDEEDEKTPSGSGKPKSTKHDEIIPDSALEPAVQEFARLIFNSSYIDATLSSMNYDANKLPLGYDSKGSLSEAISDSNGDVVKEHGNLQRACEELSNQYYSIIPHVSGRNRLPIISTEQHLKKELELVDALGDMEIASELISASSLGTDENGNALNPLDTQFRSLALSKMEPVNHGSQEFKVLQAYARDTVGQTHGHINANVKQIFRVERGPETEAFTKAGFNNLPDGERLLLWHGSRSTNFAGILKQGLRIAPPEAPVNGYMFGKGVYFADMMSKSAGYCYPRQIVTTLTMSGGIGILLLCEVAAKPFYERYDAEYNADESCKRNGKRATKGLGRTQPPKWKDAGKALSNDELIGCHMPDGGGADVDHQGYLQYNEYIVYDVSQIRVRYLFMVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDD6</accession>
    <name>A0A8H5GDD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDD6"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5362849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="515" mass="56350" checksum="0424509EF2018E16" modified="2022-01-19" version="1">MTNSKTPSAHNEKPIVQHFDNYVDPSSDPHFVEEVASHAPKLRGRKLTLALAILSGTGFTLFGYDQGVMSALLTANQFKKVFPETDDATLQSLLVAIYEIGCLFGALSTLFVGDRLGRRRVIMCGCVIMAIGAVLQAASYSYAQMIVARIVTGLGNGMNWIDFAFFWLSGSSAQWRVPIALQIVFAVVVLAFIPLYTLGLTDVFSQLPESPRWLMKAGRPAEAMAVVSALNDKPISDPDVLRTYNGIREAVNIEGSKERQISFSELFTGGRSQNFRRISLGVVVQCFQQITGINLITYYATLLFERLGISDVNSRILAACNGTEYFLASLIAISLIDRIGRRKLMLFGAIGQCITMILLAILGSIDNSPAQIVSAVLLFVFNSFFAVGWLGMTWLYPAEITGLRVRGPANALSTASNWTFNFLVFAALNAFIVPVVYLFFPETAGRSLEDMDVVFALAHIEKVSPVAISLRKDVPLAGSKEAEIILGIEGRRASPTQEREVNEKRSVSEGESNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHC6</accession>
    <name>A0A8H5GHC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHC6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="93" mass="9966" checksum="7224AC24635A6FF6" modified="2022-01-19" version="1">MRFFSFAGFLSRPVLNVNVTQHIASSPLRVSRLSNANTYRYVSSIAQGKLWSMREGFVGCFWGWLGSMSFSTGAGSDSGSGSSSSSALIITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHI4</accession>
    <name>A0A8H5GHI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHI4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="107"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5365179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="569" mass="62653" checksum="AA8F26991DA13F76" modified="2022-01-19" version="1">MRPSEVVDDHLLFCQRFSLLGTTTNHNRRAILQILPWRFNEISINLISTLYIRVVNPSLQCLRPLFSIPTSFMPNDEDGSDRNGIIQGLGKEDSDLEKTGGHNENKLTDEQPQGTKLDTTSIVVDWDGPEDPENPKFWSFKAKWAATTSVSMFAFISPLSSTMVAPATFLIAEEFGIRTTLQEAMIVSIFLLAYAIGPLLSNMFYLIWNLACGFAKNEAQLVVFRFLSGIGGSAATAVGGGVLADVWLAEERGKALAVYSLAPLLGPVIGPLTAAWIAQKSTWKWVFWSTSIVGAVIQVAGFFFLTETYAPVLLERKAKRIRKALATDPEEADQNITVSTVYDGDDRTWQRIFSKALTRPFALFAREPIAQVIGVYMAFVYGIFYIYHQTPGIAGLNYLALGVGLTSASQINARYMDKVYVYYKKRNGGIGEPEFRIPSMLLGSLILPVGLFLNGWAAEKAVHWIVTDIGMAFISAGIILSFQTMQTYIVDCFTLHAASALAAVSFLRFIAGFAFPLFAPSMYERLGTGVGNSILGTVAVSIGWPAPMLLWKYGKVIRGARPLEGFVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI22</accession>
    <name>A0A8H5GI22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI22"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="97" mass="11313" checksum="ADBACFB38DC66B47" modified="2022-01-19" version="1">MNDTFFPQSLESFAALLICAEQSFWIMSQPGSLYFEAAFRDAWKMWKEDHAKAAHLHTALGRLSTRDEQSNAFALNEWKKELIKIILENRLTHANRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIC0</accession>
    <name>A0A8H5GIC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIC0"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034439877" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="53"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="285" mass="32289" checksum="7A186D129E255D17" modified="2022-01-19" version="1">MAFYLAGPGVWSLVLLLWGSFLVPSPTVVVARNAKRGIASAPSDYQALDLMKLESTSQASWVYNWNDYPPQSVPRGLEYVPMQWGEENIGNLKSRIQHTGAKVLLAFNEPDIPSQSNLSPETAAQLWKRYIQPLKWQYGIRLGSPAVANVQSRWLKDFISACTGCTIDFLVIHWYGQGADNFIHMLKGAHQEFPNYKIWVTEWADTTMNDPAVVQTFLEQTTHYMDSQPWLERYSWFAYTRQTDGLGMQSSMPSSFIPINAICSIEMAISMHWAGFTSIEPSTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJC1</accession>
    <name>A0A8H5GJC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJC1"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="949"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1206" mass="130481" checksum="1B76DA6C5EC6F555" modified="2022-01-19" version="1">MTTTTSPPVNFWQVRAARATAAKSDSSSSTVPSSSASTSTATSVSTPVSLPLPDEADPFVVKATPKNRLPPALDDTENWPQIGKQATQNEPKKPGNDSPRKSEKPKSKWFPIPAQELQAAADTARAQRSRQPSNTSSTSASISNPQSRSRSRPQSQTAVTTNGSSKEKTTVESTRTRHSPSGSVVAHKDSSAAAPQVMQSNELPSTHHPHPHQHHPPHPTPPRFSAMSHSQHMHGPPPPSSSVVYPPYLHTPYVDSNSSSGVNGVVNGSGYYPHSQPPQPHNASPHLSSHGVPPPPSLSHSHSHSHSSSMSVPYSYSMYDYSSGYSSSPARSMTGSGVTSGMNSGYQTPFHGAGHATLGKLVFGSIEGPVNVSRSMTERGSTFNKGLAIGEGVIRKKGRRRSKDKENKREEVTEKTEAQSSSFSSGLKGKGKETDIIDLTEGKGVGMSDAVKKGIESVDEQTKKEKPQTRKWVFGTMDSSSDAPAAGDSETHRHVHRAQPSHLQIHLQQLPPLTVPVLSPIPPLPSILPTPLSSVPMPIQPLQSISSYPPPQHYYYENASLDDMSWTRHQHQQAQMHQYTHSSMMGIFGGQKSTERISQVNGANNELGVSLSRADVEGDKTKEDEADGEASKLDTSVQSNDTSELASSVSKEEPDLMSVPLSSTTATSNSNFEARNFGYGFGHATGSGTAAQDAKDGISAREQERFRDQERDFKQRERERGGEVSPGQGSPKYSSSRNLPNGPDGPIFPLRGRRGRGRGFRGERGGRGWYAGGRGRYNNQQHNSSRGQYGGGGSGHYSPHNPYAPHSPGGLYTPPYGPGQGQWPSQSGQYGQYGQYAQPPDASFTLTPPPAFHPLPLPGDGEGGMYYNPTYYNPQIPPPPRLSQPVVNGQQPHSPSSSSSPLATALNGASVQSSKEKEGQDGQQQQQHGRDLSQAHAQAPVPAPITSLSFPLDPTRYYLLGQVEYYLSPQNMAQDLFLRKQMDSRGWVPISLIASFNRVRSLTTDERLVREVVALSSVVEARGDSVRMRGDWERYVLPGAPISKVDSRENLLLGVVPDQNNLVTGAAEWPQHQYGAPEMGLGLGLGPGPQGMGQGQGQGQGVMGFEGSWYDGYPYWGNRNQRQQEQQQQQQQQFALGAGKVTEEREMNLHSLPVPAEGIVNASSQEAHPEKEDVEDEDEEEEDVVFVLGDSKETNMSGMWSPDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL83</accession>
    <name>A0A8H5GL83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL83"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="GST N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="10">
        <location>
            <begin position="74"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="7">
        <location>
            <begin position="242"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="11">
        <location>
            <begin position="458"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="555"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="12">
        <location>
            <begin position="717"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="867"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5366765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="957" mass="105323" checksum="3C2E8403735BE525" modified="2022-01-19" version="1">MSIKAAAAFGGVTLDEPTGYVHFETNRTPEFTAKFPSGKVPAFEGKDGAKLFEGYPVARYIASLAPNSGLLGHSPAEAAQVDAWSHLAEVELDVWSDIIRGITSGHIAYSKPIHTAALERQSRTLNTLEKHLSANTFFVGERITLADIFIAALIQRSVNLTIDAAVRANIPNVIRHLETIVNQPKLKEVYGPVEYIEKGIQFVPPKKEEKPKPAAAPKAEKKPKAKDDDEEDEPDVPPEPKAKNPLDDLPKSSFNLEDWKRAYSNKETRGAGGALEWLYENFDKEGFSLWRVDFKYNNELTQTFMSSNQVGGFFNRLEASRKYLFGSVGVLGKTNDSIISGALIIRGKDIEPVVNVAPDWESYTYSPIDLSDAAQKEFFEGALAWDLKVDGKEWADGKNGLGPRISNLEKDNLIFVEVKAVENGVAAPAPTTEEPKTTGGDVVMDDDEKERKGRARRQTCQLSRVLSKKSTVEFYFADSNLPYDKFMWQLHTKDKDHWVPIETVASFKRMREYSKDGIPWVTDALRESELLEVDETGTKVRRRSEVKEPQGQFERSVYAKGFGEEDPTLQSRLEKFLQGYGSTNEVRMRREQDKSFKGSVFVEFTEPSGVNAFLNADPKPSWDGKELLIMTKEAYCEMKIKEKGLTGKDAERKKGIMNKRAFNAFKTPVSQGGLLADGDVDMEDEGKPKIYLEYFGKKLLIHRDSSGNGKVKDEEVPYVKGASLKFEGVGDNFAWNDIKTPLKDLLEGKVPFIDYTRGQNSGLVGFHRELSDEDITAIRKAVRTINGNEITWSKIDEEEEKKFQIMRAQSSARNAWRNTQENGSGGRGGRGGARGARGGARGGGRGRGRGGKERGRGRGRGRGGFRGGDRSETNGKDKAAEGGDASGSGSGSGSADGNANANGTDDTRAGEKRKRAVEPDGGPDVGVRGQGAPPKIQLVAPPKKVKTETGELPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL86</accession>
    <name>A0A8H5GL86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_004029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL86"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="564"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5367144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="844" mass="96073" checksum="12B38A9AC99E457F" modified="2022-01-19" version="1">MDKDNRDDFTFAKLSDLKLPVTVRISQLEGNRQPRPFTELLDHPEYKFHGVQSPTLSDLYVTCQLVADNKPLTIPFRTSFKAFKNTYTWNEWITFPIRYCDLPLSAQITFTVWDIAGPRAATPVGGTTFRLFGKKWTLRRGKHRLLLWPGIEADGSNESTTPSKLGVRDEMGRLEQLVKKYERGDLPKSDWLDKITFRKMEEIHAAEAAKSENLFLYIDVPRFDFPVIFSEPEAPILPSTSTLPPQPQTPVGPIASFTADSYLWSVIDPDISRENPVEDKHRRLVRSHRSGPYDRELKPNAKDRDMIGEILNYAPSQPLSPEEKDLIWKFRFYLARDKRGLTKFLKAVTWRDPSEVKQAVEELLPQWTEIDTDDALELLGPGTVDSRVRAFAVRQLTRADDEELLLYLLQLVQALKFESAASDQRSSRSATNAISYDDSGLTDFLIARGVQNLVLGNRLYWYLMVEVALEDKVVSKMYGRVVFKFMNKILESNNGSERRELLRRQGQLVETLAKRAKELRTSKDPRPKKIEKLRSALADSKNNLTSLPPLPLPLNANIEITGIIAEKSSVFKSNMYPLLLYFQCSDGSEFPVIFKDGDDMRQDQLVIQLFTLMDRLLRQENLDLKLSPYDVLATGPQQGMAQFIPSKAIAAIVSEHGNVLNYLRAHHPDEGSVGTSGIEPAVIDTFVRSCAGYCVVTYLLGVGDRHLDNLLVSPDGHFFHVDFGYILGRDPKPFPPAVKVCKEMVDGMGGANSPHYARFKSFCFTAFTILRKSANLILNLVALMVDANIPDIKHRDVHEQIQEKFRLDLTEEEAIKHFETLLNETSYITVVLDRIHDLAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLJ7</accession>
    <name>A0A8H5GLJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf/Ham1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLJ7"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27271" checksum="7D358E92733F77E7" modified="2022-01-19" version="1">MMPDHKHVLPHALQVPAIKKLAGKRIILASNSPRRKEILQIYGLAPEIVPSSFEEDLPPHSFQDIHEYPVATASYKAVEVYERLVEQDPDDPPDLVIAADTIVLTHAQPSTSETGYSVLPQISQELLEKPASKQDNLRMLLDLNGGVCEVVTGVTIAFPILQAPGYGLKSIDERSLVYFADNPRHVVEAYAEHGEGIDRAGGFAIQGVGGMLIRKIEGDYNNVVGFPAASFFQLLDMMVDEEPDFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMA0</accession>
    <name>A0A8H5GMA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMA0"/>
    <dbReference type="OrthoDB" id="3223825at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="33806" checksum="C285742121591C4F" modified="2022-01-19" version="1">MLELSTDSSNEQTPPDDLFLERFEAFMAKSLAEIRAFSEREAMSFEKTRRRVAQWHSKYLFQPPDSSSVDPPASEPSEDTRVHEIRGVLVKTSQILEDLWETAGVESFLLAVDLRDSSNEGFLGGSVAGREFWRGLRNGGEHGARIFKQHCLKNKDVSSAEEVGSTSSSGDISTSVSVPTTPRQSAKSVKQELYENVRNALRLACGIRNAEMKWTNPERLQSYGVHLLGWPNDIPLQNPSSLKTSQNKRLLDLLENGIMKFVKITTSNDNEPAAPIQNSSAKVDDDSDTFLTWIHFDGGSLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPV1</accession>
    <name>A0A8H5GPV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPV1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF132">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56441" checksum="37EF22213B8BE24D" modified="2022-01-19" version="1">MVPSTQKHILFHNTAAWGHHKPILPFAMQILQSRPNVIISVLTGADVYAKMMAEVDKLPDRLKEGAKAGFHVIDICGRPLNPLVPCLEFEPTFKAIYNGETIKCLSSGKEYTLPPVAVGIIDPFSGYAIEAIREISGNKTPYLSWVTGNAGCGLLLFKGTPSGKLNMQTVRYGGEQDVMPILSEFAEPLTGAVKSAPGIATMYDYEIYPQEFPLAGDMFIDLARTYIASGQGMFILSSTPYDGEAIDATKEWFSSLGQVAYPVGPALLPDSPSGPSVTSTRGDIKPVVEFLDKMQKVHGEKSVVYMSFGTIFWPQNPENVWAVIEELLASGTPIVWAHPSPLCVVPEDKLKMLQDSDIAFEIQWAPQEEILSHPATGWFISHGGWNSIQEAMHYRVPQIFWPIGADQPVNAATMTLVKKAGFELIEVRTGEHGTRKMYRFKDLDPKDLPTFTVDAVRREIRELVSKLKGEEGMTVRKNFEKMSREFTSVWNEGGEARESMNAFLKKFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ72</accession>
    <name>A0A8H5GQ72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ72"/>
    <dbReference type="OrthoDB" id="2891248at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22139" checksum="666271CE92DE22E4" modified="2022-01-19" version="1">MAPQTSSSSTETAPPAATSTSSPSGPTSSRGANYFFGFLVTFIALLLLFIGCGVGSRRRLNRQRRILFGELEGWNSSFQTLAEPPPEPKLLEPLFEPCLRKTGGEIWRFMQPLSAKLVTVPSTPLKRPPPPVRFPSHNPAAIHGLSLPVWRHVAPTEKEDEGSPEAEIEIAVLIALPRRDEQGRHDYEIGVAHVPWDKGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQT7</accession>
    <name>A0A8H5GQT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQT7"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034680637" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5369588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="564" mass="61491" checksum="96952755AC9EA88E" modified="2022-01-19" version="1">MHLEDFTLEFLMPHLHWSLLVTTLSFSSLVAGDAISPAQFHRTDFDSTCSSIASQLSLPNATVFFSELVTQETNLTFPERDPSCVAPTISPEFLVVPADVCRISLAVQTSDRSGINMEAWLPRNWTGRFLSTGNGGIGGCIQYADMAYTSALGFATVGANNGHNGTSGRFFLNNSDVLEDYVYRSIHTGVVVGKEITKAFYGSEHTKSYYLGCSTGGRQGFKSIQDFPEDFDGVVAGAPATQANNVVDSYSHLFNITGTPDAPTFVPQETWLNIIHPDLMKQCDGIDKVEDGVIEDPHLCHYDPSGIVCSGSGDNSSCITAEQADTVRKIFSPFFIGDEFIYSGLAPASETAEPLVLSLAGDVATFSTEWFRYVVNSDPNLDAKTLGESDWKKCLALDPFNFSTFKGDISAFKNRGGKVLSFHGQADGLVSPNNSEIYYNHVSNTMGLADSQMDDFYRLFRISGMLHCALGPGPWNVGQGLFGDTLPGSDYLDPDRNVLMATVKWVEEGIAPDTILGTKFVNDTNNLGVEVSRKHCRFPLRNTYDGFGDSTKPESWSCQPVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQV7</accession>
    <name>A0A8H5GQV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQV7"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5369544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="20585" checksum="B247024C7F4D2FF4" modified="2022-01-19" version="1">MSISRLLHEFRPLFRMLDEPIARAPNSLASALRTRPFIDDPFFTSPLSAFPGSGLRPAVDVSEDGNKYIVEAELPGVKKENVEVRIGDDGRSVTIQGRVRSVKSEGAPETQTGQQAPEANNSTKDVAQTDNNAQQLSAERHFVGDATFTRTVWLPRPVDSGNVSAKLNDGVLTITVPKAEDKGSVSVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR88</accession>
    <name>A0A8H5GR88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_002797</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR88"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="158"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="16">
        <location>
            <begin position="464"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5369430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="668" mass="75068" checksum="616ED5EF1AE4EC03" modified="2022-01-19" version="1">MVIIWLKEYRNKTITRIFGGNAYYGCYFLALSIFSFGILRDTIYHKALLEQPKMALLPEPYATVVPAALIGVGQLFVLSSTWALGITGTFLGDYFGILMNHRVEGFPFNTLRDPMYVGSTMCFAGGALCILDCAALRREMTWFAGMEQYLIAFTTNSRRLTFVSRRYMSYNKWNSSESLEMTIYNGFHQWFRLLVPEPKDRIPITPIFLLYWSAYHVPFFFLAYLARRPDTYLMRLLLLPTALICSIVVAYRYTWTISSLNVYNWGQSLAAAVQIAKALEYALTPEGMLKYGEVAPGQLAKASNGSPNGARNGYANGHAYTNGHGHPLPRSKLRSRWPAWLTDTIALTHSLRGLSFTYSKGIHIPAHTRPISSRSAFAKSTFISFVKNFLLLDFLESVIKLFPGVGDPSGGSMFYPSLPLVQRYAVSTFVHILTGSSLLAGFGMVYDLCTFIAVALCDDDPANWPPVLDNPWKSNSMHELWSKRWHQLLRRTFIVFGGLPSYHLVRFLIPPMFPGARKQLSEIVSVVGTFLASGLFHEVAIYTMFSPTNHATFSSAPIIFFGIQAPVLIFERLFSSLSKVLFGRKMRVGGWPGRLWVWFWMFGPVSQNMVDSWHRRGLGSGMVIPPFISPARFLLPFIVPWLAKVAGSLYGGIGITGLVGREVPRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRA8</accession>
    <name>A0A8H5GRA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRA8"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034759884" description="FAD-binding domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26649" checksum="2D8317B3A6F2E7A0" modified="2022-01-19" version="1">MLLVGCGIGGLAAAFCLGQAGHDITVLENMSQVGEIGAGIQVCPNLSRLLIRWGLRERLKEIAERDRPQAFTFCRYSSGEKVGMSRLGDKLERLHGAPCRLMDPDTLAVRLESGESITADLIIGCDGIHSVVRNYVLREGNIPLAVPLGDVAYRAIVPTKEMLDDPELRSLVKNQEITCWIGPGKHLIGYCISGGEEYNMVVVKADDGSAYSWTEEGDPDELWAGYVGWEPRFEFKRSSAMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRV1</accession>
    <name>A0A8H5GRV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRV1"/>
    <dbReference type="OrthoDB" id="10580382at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22835" checksum="8D6941EA3210E570" modified="2022-01-19" version="1">MALARVKGPRSNRPVTTSVCDSTEYHLGLPRTSVDSIESTSSQSTRSDESCLSLAESYASSSEESDYRCDYDNCCSLKRRAHIRRQCRRVDELRPLPSLPPSKSQIRPLPHPGLTQIWRKRRTLPKPPQLRVALDLDFPPVSPMTCTTPVYGWHAPIRYSHLIDAQINWDVLMDEILSNDSGSIMMDNLEDSSMDMASKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRW8</accession>
    <name>A0A8H5GRW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRW8"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="843" mass="92532" checksum="C5F4B148B543F4F8" modified="2022-01-19" version="1">MYNDDAPSVILNGHPIFSPSKNVSSAPSSSQWNVELSAKTLSQFLDANDNGEGASLSGRRQVMLLRDTDLILAAGKSIRMASLSGTKIQRSTTKSYKTLHTPNIEFDIHQIALNPNGKLLAVAGAFQVAVIVLPRAGYSRLVPENIECKSVQVGQFYHASNSAPPVVKIEWHPWGEGGSTLMVMTVDGKLREYDISVDAEEPQQVLSFVPERKARMSFIAEDSAEREVVSFTLGKGRADWGPLTVYALMKSGDVYSICPYMPRNASVPSVYVHSLECFIAAKQEFLSQGGTSAASKNLSTLYDYQHKYISALIKQLPPGTVFPSPSRSVLMHPPTTIKSAPARQGPFLLQPSPRILDGSDGGDATDITYLNFSEDYDQDADGQGGTTENLGVVLIAYQDGKIDFCLDVEKVEARWETKQIPNTDLPMFAVYETIDLGLVSVLGSNSSQELLQGNYPVCLPDPIHTDTIYVYHAFGVHALHLRPVLQNIIAMLHSEDDSTSSSAITTNTVIQPILSTFSVQRKSSNPVIALAVPDDVYLPYSILVLTSSMRITSFALNPQPESLSTTSKPPAIEGLKIPGLKPADDGPLAYVSLLGTAPWKPPEILSRPGGLPSNPKLSLPDGTQSELILTPDTMRYLASTVAQLSAQIHEIQLAYRGAEGRAALQGQELLRLTSKCRELLGKIENLRVSRLNETETRLMKAQEEQKTLMRRLDRMIQTMMEKASPELSEHETKWFEELKRMKEDVVGAGKYDEGSLASRTKSLQREFDRLMPSLKAMVVKEQLRKSKTAESTRSLGFSQAFELGERSNFERARISEVENDILKLAELLDVTLGRPPSSTATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT39</accession>
    <name>A0A8H5GT39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1677" mass="187891" checksum="5E510CB229779B64" modified="2022-01-19" version="1">MAGLDMFSKIPSRLTAQFGLLPDAEKLAFRREPGGLQKLASARNIPETDSYWNQYVVLFDSASEVFSLITPNDIRRALLDAPENVATLIRVICSRLFNLISDHTFPTPTSASVSAFATSFIKAGTSERNTTKEVLNCLRVLQRVLPVVFDVEGESSVFELEVLWKKAEIDDLEEGEGTASATPQFVLEDDEDEDDEEKEQQPASPKPRQKKHLPSLGEKLFNAIIDLMFCCGFTLPTKIQKDHHKINYVIWEKGIGSTMDPGPIHQYDANKTEVLRLLLVLLSRQIYIPASALFAKPSLYTLHLVQKLPRRDVLTVLCSLLNTAMNSSSGPHSSSIGAMAGKLPYNHLVFKGEDPQVNLAATCFEVLVVLLDFQSSSARDVLTGEGELQSSSPTARTNAFRYFLMKLHRTQDFAFILNGVLGIMEQQIMITNNILPGARKSIPYVAENIIFFWKMIELNKKFRSYLLESDKSMELVAYLLCYNLEIKDKPQQHGVCRALSYIIQTLSAEPAFGLKLTGPVKAQLPAKWHTTGTMADFLINAIYSVVATTSGALTLLYPALIIALSNVAPYFKNLSVTSSTRLVQLLTSFSNPLFLLSDEGHPRLLYFMLEVMNSVIFYHLSDNPNLIYGILSSNKLFEQLGTFTLSRGLREIRRAQQGKEDQAQRKDPADRRVSHRQSNDERPPHEEKKRLLSNEENQEEGIISLEEQRGRSDIERPIAEAVDVGSEDSGPSEKAKGKMKERRSSSASSSLERLAAQGVGRNGFVPTQEWVTSWHQGLPLDTVMLVISELLPKIQNMQASHKTNSASAIYDFLSEVDLKDVLPPTPPLNPRRFMWSDASVIWLTSLIWGEVFVRGMTPLDPAASDYGNCVERCGRYFGKDELGWVVIAGTDVTRIIFISNKSYVQQPPINFLPSTPKMMGPRTMDSRSSITHQLNNHYEISEQRPATPPTRPTHIPAPTSFTKGNKSPIRQSFRNLVGLIKKAQARVKRPDNSSQASPRIPAKETKPSSSKSSGNLIYLARPTNSHLLPVWTSCTATLNGDKFSVSWSTAKNNPDSFSVDLKRCTDVRSLSSSQLSPEEVSQLPSSEDSQELKVFEVVMIDKSREKFAASSNHERATWVSAIWDVVLLLQDARSVQRAQPIKAQTEVSDQPINQSQYVPKSEDRDLPAIPSTSSTRDDLSHQPLDHPGRPRSPMRQNLYCSADGSTSRHTSTTLTIQAKPMQHTSSPSITNLSQRSMVKQRLAQMERHRDPSTSSTFPSLIPSRYPQENISTRAEIAESTTSDSIVDSYAEASSMPAQGYHHVRATDTAARQTSSMQVIQEDAREHHFHDQSLHIQLTALQQDVQALNRNLASFITQPPGAVESRNICESLAMIGKRVEDSGYRVALVNDNLEKMSERIATFALSLPPDTILQSMENVQNTLFLEISAVNRKMDDVFRQMPMSAPNENQIPKDEDQMAKILALLAEESNQRALHGQQQSDSVRYLNELNSWLETFVKNGISQIQAMGVTVQQLSDVMALKVDNKEISPVRLVHQFMEWMVQYRQEQENLLRALTAGNVPIDVLNVLHSLTSQGLSSEIKGERLRFVEAMKEATAINVQNHVEEFKKHLRHEVKGMTQEVSRLYREKQTLENQIADLLDFKRKAGHGGMVVAAAQSTRHMQQQQYMNYSPSHPNLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTA2</accession>
    <name>A0A8H5GTA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTA2"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27669" checksum="DC83B2C4116FA7BA" modified="2022-01-19" version="1">MWQDSSYASSSSQSPYYAQQQHQQNLQFYSPSPSDGSLYPGSRPSLEGSMGAQGNISNGGVPAYGGNIQSAGGWWTAFGTGGFEGEPPLLEELGINFSHIRAKSMTVLNPLSRVDERIMDDADLAGPILYVFCFAIFLLFAGKPNFGYSYGVGLFGSMSIYLLLNLMSEKGIDAYRVTSVLGYCLLPMVGIGAVSVMITLDGMFGYLLATISILWCTYSASGIFVAVLRMSEQRLLVAYPVGLLYGCFALLSVFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU40</accession>
    <name>A0A8H5GU40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU40"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5371268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15088" checksum="24BEB5B16C851A75" modified="2022-01-19" version="1">MKAMALFLERQEAAQAEMDSVLGTNDPAYGEEDKLPYFKAVLCECFRWQTVVPLSFPHVTNQDLQYNGYKIPQGTVILANVWGILHDLKIYGSNADNFDPERWLKRDERGWQWDNDLPDLYHLSFGFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUP3</accession>
    <name>A0A8H5GUP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUP3"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="155"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5371611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="587" mass="64843" checksum="B1585C4732C7C94E" modified="2022-01-19" version="1">MKPARFLSEIHKAYRLPPTIKQLLASPSHISSTKNSENAVSNKVTVNGWIKSIRKQKRVSFATVSDGSTTAGLQAVLQSSMVPKDLTNGASVRLTGLLEESRGAGQDKDLIVEKVEVLGACDPETYPVQKQSLSNEFLRDNVHLRGRTTSIAAMLRLRHALQKGLVSYFEEQGFTYINTPILTSNDAEGAGETFRIAKVKADTSSPDASPSNSSSPLSPHTSSVPPPPPTSSPGPEEKQEEFFSHPAHLTVSSQLHLEAMQTAISRVWTLSPCFRAERSQTNRHLAEFWMCEAEWGDLNIGSVSGPNAGVHGICTVVEGMLKTVIGGLLKDNGNDVLGGLNPNRAELERFVSEDSGPWMRLSYAEAIEKLQEEYVKQLQLKGQGDTQASPLPFEYEPQYGKPLQSEHEKWLAEVYARGPVFVFNYPKQLKPFYMRLNEYNKDIHKLRQEVACFDLLVPGVGELVGGSVREERVRHLVGAMLVAGLVKPKPGCEGYIMKWLDTSPLSPYELPVSALPSDVTDDKSDWGLDLDKIDLGPYEWYVDLRRFGGAPHVGFGMGFERLVGWVGGIENVRECVPMPRWAGRMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVM0</accession>
    <name>A0A8H5GVM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVM0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="141" mass="16325" checksum="CA9D71749D7F0CF5" modified="2022-01-19" version="1">MYRALSYSSSNDDSLLLKAWRKLKNIPFYDFHGQSYENSKTLKTLDSRLSRPRRLDYAEIYGGSPEHDQSVVVLATLKDPKKIAVLCIFTHGHLKAVTEAYWHQTLDLRNPVPSEWRVITRLRIKSNVGGLDLYQDLDVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWS1</accession>
    <name>A0A8H5GWS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWS1"/>
    <dbReference type="OrthoDB" id="3056812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0041">Annexin</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="6">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="791" mass="86796" checksum="985A13E3545CFA8F" modified="2022-01-19" version="1">MEKNISLDGSILKAELKQLAGNWVADKIDLSLHIKNDNGKLVPIDATTLKAPNPTPPPTPVPLSTSSIIDPPPAYHKESLTKFSAYRTYCSSQFKSQESRSSSYFMYSVASDKLRLVGSTLHAECLTLDGSYAVQTLDLAKYIGVVNGHLVWGCRDFHSACRSVKLEGYVLHAECHDEKKVVIKSSLDLSRYLHSYDGVLSVKVTVDSSELSKLFSEARWLKFRVVTEPDSSVVVGGSAFKSVFHSLAEATSAYVHTEMTQYLADTIGQDIKSLLIEKVRAEMTETVTASMTMALQKQLSEKIEVAFAATKKTVIESCDEVINVAVNKVSTQCTESVVLSVGEHVATQCNLAIASATQEVASTAITHFRENVEILMEQQMVVASTRRARTEAALLAVYKELGAEGVLGSLGDADHPSYVPSKTPLPGPGARHGQHTQQVFYLGTPIPSLHLQTSSLVTLVPGYNPNTDVEKIRKATKGWGTDEAAALHLAALGAAFKASVGENLVDILRSETSGWFKSTLQAIALGPLFYDVHLIDEALRGAGTDEQLLTELVTDRTLEDMRLLKEGYAYKHQKGGDVDALEREARGGLSGVVKTLFTISLSSHRAPENAPVDHALVEKDIKALYEAGQGKIGTDEIAFCDVLVNRSRAHLGVLCEAYEKKYQKLTKVIKSEFSGQLRDTLLYIIQGAKAPNDKSKDHKDKKNKDHKAPVIPETWGIIRDVKLLEKSMKGLGTNNKELVRRIIRLHWSPTRFRLIKDAYYHKYGKSLEDRVAGETSGDYKKLLVAVIRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY09</accession>
    <name>A0A8H5GY09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY09"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="336" mass="38483" checksum="59DA0E7BDAE64D38" modified="2022-01-19" version="1">MLKTFYGKATLTRPFHHVIIGSDRSALPRRSEIPLEPSQRYSAEQSNLWETARRVAPGDPEEGLHNLLANDILVVERQIEMLNIFLGFEQMNKYSISNADGQPLGYIAEEPGGFLSSINRQIFATHRPFKAVIMDAAGKPILWIRRPFAFINSRMFVQRLVEYDPKGEPLLDTFAEVQQVWHLWRRRYDLFMRDGPRRILSLASEPQPEPEPESEGDTFAQIAKVDEGFLAWDFSLQDARAREMAFISRSFRGIGREIFTDTGQYYIRLGPRPRELLANGTPNPYQPDGIPRQLTLDEKALVLALAVNIDFDYFSRHSGGHGLFGFSFFEWGSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYU8</accession>
    <name>A0A8H5GYU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYU8"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="44733" checksum="2E2CD7C2134E187E" modified="2022-01-19" version="1">MTLTATLNVDRTRAHFPALESGHVYADNAGGSQVPKDVVDRISDYLLNTNVQINVDYSLSIQSTQRVADGKTAAAQLFNAARVEQIILGGSSTANMENLLKQFEGEVHLGDEFILMDGEHEANNGTWKKLAARTGAIIKYWHPVITSPENPFSVVHHVEHLIPLITSKTRVVAFSACSNILGSVIPVKEVTKAVRAEAAAKGARKVDISVDAVAYAPHRRLDVQDWDIDFCMLSFYKVYGPHAAALYVRSPLRPSSSSVAHELVYGSTGILPYLLSLTPLNDLQATFDAITSHEHDLVQPLLAFFTHPDQRKRGLMLVGSEDSDASRVPTISFVILGQNPISSPEIVKRINQRGGVGIRGYKYVCTTEDGVQLPLDDGVARISLVHYNTVEEVHKIIDILKDILYSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H2G2</accession>
    <name>A0A8H5H2G2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H2G2"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="33677" checksum="20F6A46F4403EB20" modified="2022-01-19" version="1">MFSATSNLDQSDTHTPPTNDVQDPHLANSLDVLSSTSPPTSSGPVIAVDLDDVLSQTNAKVAEWHNEKYGTKMTLSDFYYYYYWKNPYWGDLQETFRKVNDFYATKQIFEASPVPGAREGVQALRDMGFRLIIVTARTTDVKEESWKWVERWFPGMFDSVVCTSQFKDANKAGHEVTTKLSKAQVCADLKACLLIDDSAENAFQVATSSMSNASPAPSTPVLLFGQYEWNRRLCLPSDQIDSMVFDTRLEIEEGKEFWREERLEDHIPEGAPLHRVKDWGEVIRWVKKAREEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGR8</accession>
    <name>A0A8H5LGR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGR8"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="178" mass="19794" checksum="2BBB2DC79583F8D7" modified="2022-01-19" version="1">MRDGLHVKLVFCLNPTWRNLAQSFGASKVVGVDIDDTLIRGAWRRRLQVWSAQAPLSELHPGTENDETISDLASERPSKKQKVVESSGVLDANSNANGSQSLPPDSDYFPASFEHSFGALPIPPSHLRGKDVFPHNITFRTADWVEENIIDDGEGYDVVLAFTEILFPVKYVSSYNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHS6</accession>
    <name>A0A8H5LHS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHS6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="112" mass="12995" checksum="E3646667D3E3D12B" modified="2022-01-19" version="1">MAWPEQFKDPDVDGDYYGGGNLHSDDDDKTRDKDESKCEDKLDKKLRVVIEIEGLPSKFPGDEAKHVGVVAERHRSDEYTDSDETDSQEEEEEEFESMYLDPYGNDSDFYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJ18</accession>
    <name>A0A8H5LJ18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJ18"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20208">
        <property type="entry name" value="Bbox1_DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5359032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="641" mass="72652" checksum="F316C67C99E92536" modified="2022-01-19" version="1">MDPPNGAANGSTSKTGLSLKSILNDEHETNDNPDINGSEVAEGWDEESTEKPAAEGFCIECEDQPAQLFCEDCTDVYCEVCFAAQHRKGSRRTHKTKPLENAHLTKPKAVSKSQENDDEMVVDDAEDDVDDELERVVAGVPQPSSTSQPADGAKVGDFFVERAKYIPMRLTLGERKYLRLLDASLNVSEYTDKIDVLSFGQSKAKRIVAQIKELCAVMSGLLLAADYKQGQELFEDRDFQANEEFYQLIFEIGRRHKIMNPDKMRTTYGKLIYILQDSQSPDVKDLLGFDCVRPIKTVHTLLKEHNALDMLRDDLITVATKEIYSEGRSRREIQKDIKSKERAIENLASRYERKGLTQENLRQCLYSIGDNHAFLRANRDPCDRVIAYLKEHFHPTQAKDSKSSLAIRSGKGGARLSHDHRKLCLYCFRPLLLAQSSKSQKKQYAYVLQSLTLWREILHDMFHLWSLAEEDLLSDTISYRLRDTGQGLNRVQASPKTSRMMHSILHKAQKSVGSWVGSSVIHMGDHNVPNALLFIDKYTQIYRILLPICNTLSQIPSLMEKPALRSYIEDEFGSAENLAREILGDFFRHGFDGSGADNFFDAGSCIDGRLTSAWNWCSNLEKKRFFPVFLLSGFIGFDGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJQ8</accession>
    <name>A0A8H5LJQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJQ8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5360080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32966" checksum="E392CAA778799D5E" modified="2022-01-19" version="1">MENSAKTTLKALKDGPFEVAMKAWASGSSSSLVGQLVSEAKNRYPDEGNSEYLAEIESIKSMGFTALAAASDTTVSATTTFFIAMSLYPQVQKKAQAELDRVLGFGRLPGFGDRTSLPYIEAIYKEVMRWYPAIPIGLVHKTTEDIFYKGYYIPKGSGISANIWAMGHNPAEHENPDEFIPERHLQDNGLGEPELKSGFGNVSNILAYGFGRRVCVGRYFADATLWLTMACVLATMNISRDSINSTNESVSDEDLKKNLEDYYTDCSLSHLKELPGVKVLPRLSKEELEGLFDQDKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJW6</accession>
    <name>A0A8H5LJW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJW6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="234" mass="27178" checksum="1B6819306CE91574" modified="2022-01-19" version="1">MTPTFPPPRTGSPQRRTQASASLSQASPPHDRISSRTHEDYEEKRLVAHQYRWLEEDLAFTALISIEEFLQLVFAPTNRFNDSKKDELSRLVRDFSQENKKYKDARQTYLKECARRKGTVDENGRKLQTKDINEDQLYDPFAELCNTVIQEMGFLTDDDDIAEDTRVLFYRQDPYVIGGLTLTQRKSDLGLLGQNRKPLLKEFGGDLPKNMAWYVLAHWVEMKRFNGNALLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LKW0</accession>
    <name>A0A8H5LKW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LKW0"/>
    <dbReference type="OrthoDB" id="3265563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="376" mass="41897" checksum="9F72DDD9C4979583" modified="2022-01-19" version="1">MITARYIYKARAIHLIMFSFPTRTVEMSTNNFSQSLPSELQTRRYEIVIPLAVATILYGAFCVLFGVCIHILLQKQKKVQIRSTRHGHGHSQKDFSFWFHMVTSTLLFASATAGVCLSVAFTLDQLDFSESSNETGPGNRLFIGSAFLYILTNCIADMIIIYRCYVIWGYRKGILTGAILLSLANNVTALYFAILTVPQHSDVTRMWEISYSGANVFVTYAFLFVNLFVNGTLSGMIAGRIWYIQRSFQRSFGMNLARKYDSAISITLESGVIYSFAIIILPLVPFFSKNSAQFNHQGFLLIQIAGIAPTLIIVRAGLGVSTENVPQHTTMLSTFRARSEPERVEGTNSADEQVISLEDHISDIGSEGLASKHTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LKY8</accession>
    <name>A0A8H5LKY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LKY8"/>
    <dbReference type="OrthoDB" id="3354175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="337" mass="36742" checksum="996951BF43642DF8" modified="2022-01-19" version="1">MSAPRNDISADTAAALSLALEWGLYGLSVYMFGSTMRSLLRTPPVNVKMVAITLVFFTLSTSHAIIDIVRLNQGFVNERNSFPGGPNAFFGDATQIFFLIRSSLYVAQTLVADGVVIYRCYSVWQSYYVIIFPSILWCSVLASGAGALNSLAEAGRANGAAEIFTFAKWINSFFGSSLATNIISTTLLAYRIWAVNKQTSQFRKDDRGPLATVVRVVLDAGILYSVTLIIALITFLTHSNSQFILLDVLMPVMPIAFYMIILRLSHARKQLTKSSGGSSGGAFGSQAHNQGSYPLRPVRIQIATQQETDGPGKQGSSESRHIDDFELLEVSKAQNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LM90</accession>
    <name>A0A8H5LM90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LM90"/>
    <dbReference type="OrthoDB" id="5582182at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="396" mass="43613" checksum="1D975A847BFEF8FA" modified="2022-01-19" version="1">MTTPAPDQWSDHGHQSIPGDVNGPDPNAQATITHNDVNIMKGYFARFDAFQADTNTRFNELSINLSSMQSTLSDISSQLKASGKAPDPSSSAPPPPTTSTSTSAPIPATTSTDSTKPPTFTPPSLFKGKVTEVEMFIHSVKDAVELLGATLPTDRKKGIYMGMHMADSAKQWYNSIRINEDHLLDSFADFIETFRKHFGDSNLAYNSARKLKALTQTGSTAAYAARFKELLIHVTWSEESKVDQFYEGLRPTTKDLISATKRSERPTKFLDYVQFAIDCDNRVHERNEERKDESKRSTSTSTSNSNSNKPPKSTSSSTSNSTTGNGSVYMGEPMQVDATKTQARKPLTEAEKKHRKDNGSCMYCGKCGKTADTCPNRSPFVVKRMEEAKKTSQSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMP8</accession>
    <name>A0A8H5LMP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMP8"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25830" checksum="164C654B2CAD5351" modified="2022-01-19" version="1">MITLYDNKSTLPLSHPYCGYSPYVWRICFALCFKGFAYRTHWLEYPNVKTIAESIGAPPTGKRPNGTVRYTIPIIHDSVTNKVISGSFDIIEYLDTTYPDTVQLIPKETRLLQKEFMNSEAGRVSYPPPVVYSEEQEKEAWEKFKNSAMGDMAKQMLDSEEAPFVMGKKVSMADAVLFGRFACLRLLWDESTKEWKEMMSWHGGRWGRLFEAYESLPQVEKYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPE4</accession>
    <name>A0A8H5LPE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPE4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17510" checksum="45CB95A2FE4B286A" modified="2022-01-19" version="1">MTVSGYEDEDRDNLNTILPADLKRVPCRKNILIFTPTRHHQGYKSTPSSSIGLKTCLRYDSYATLGGSDQETIRSRIFSLKPADLGTQNGCTSLQLELISFIFYSYFVIRAHDASPFGSGDLAITGTTVFKKNGRTSSALKRARYEDWDGEENGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR26</accession>
    <name>A0A8H5LR26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR26"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="794"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5366845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116286" checksum="49A2BD21DBB6DFE5" modified="2022-01-19" version="1">MSTLLPFHSSILNEIHDPATSDLVVVARGLGLRRIICTLLKIYDSPQNLVLLVNATQEEETEIGEELGIMGCRKPGLRVVGYETGSRDRQDLYKKGGLLSVTSRILVVDMLQKDIPIDLITGIMVLHAEKISPLHLVSFITRIYRENNKTGFLKAFTDQPEHITSGLQPLKNVMKELQLRRVHIYPRFHQNIKDTLERRRADVIELSQDMTPAMEDIHGAIVQCMNSTLAELRRSKDLDLEGISLPAAYFSSFDHTVRKQLDPIWHKVGATTKALVRDLGVLRRLVGYLLTYDALQFHSFCQLLIAASNESSSSTTKITTNKDTSLGKSQWMFTDAANIIFERAKQRCFLTITPVKEATPASNMAPNANVIDLVDDDEGWNAIYELEGRTPLPTRNQSAKSDKRPPWLPPTMRPVLEELPKWSLFAEILEEIEYEILRMENDALTSRGKTLGAPEIGTNTTLVMCSSVATCNLLTEYLDKMDNKRPKGEWGRRMMLKKLKNWLWWEQKKKMLIEKGGNAAATVATLNGINMNQVLTSDAGGSGAFMMGDEQDGNDDGLSEALKKKDRDKAQKQASRRRVRGAAPVNAVGGRGSTVPPAAQASTSGNPNVNDEGAPAAAERAADDFFKDADMELLTMDDDEIQLNFGGAADTTQLTFATEFDQHYGLLPPAQTVLIRAYSDDSDDRVLDELKPRFIVMFEPCMEFVRRVEVYKSSNPGLAVRVYHMVYSNSCEEHKYLAGIRREKDSFERLIKERGSMLLPIYDDHSRIDSDALIQTISSRIAGGRRELSTAPSQVIVDMREFHSTLPSLLHAAKLLVIPATLTVGDYILTPEICVERKSLSDLVSSFSSGRLYTQCERMSVHYKTPVLLIEFEEDKAFSLEIVSDLKSYAKTTNRYSPKKKTTGNPSEHDAYSSPTIQSKIVLLTLSFPRLRIIWSSSPYATAEIFNDLKKDRPEPEPSKAIAIGAEEDPNVGAGINAAAEELLRSFPGITPKNVKHVMSKVNNVRELCEMDIVQVQGILGAEPGKACYDFLHKGEANWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRU9</accession>
    <name>A0A8H5LRU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRU9"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35038" checksum="2D3BECC16F2AB8A2" modified="2022-01-19" version="1">MNGLAAYNDESDSGNESQTQTRQGNGKIDKSLKAISDAEQEPRRTSQPKKSQIIIKRPQRKPNTVHHPRGHISDDIASSSRAEPSPMTSTPAGPSTSSANVAASASTSEPEEELKRIRSLLVPPPIPDVADWGIPPEPALEENEPCDPAIEAKVRQFHALKYPSAPSDDSPAPTPRHFNDSLMSNRSFRNPHLYAQLVDFIGADERSTNFPKSIWDPYAPLHAGEGWDAEKIAAYQKKRSEQQAQAQAAGKRSHIHFQSSSTSQSHNKDRDKNARDDGKYNPYAAVKRSNGAALGSGRSSGPTQPTARVLGGGRGRGLSRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSR3</accession>
    <name>A0A8H5LSR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSR3"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="24606" checksum="2D8464C27F0C4AE8" modified="2022-01-19" version="1">MTELVVQRITKMTDAEVDYLAALMKEEYTGQFAVLILVGGDWSLAEEFWTALTRAVLLEGHLYAIKNEEGKIVSAGHWFPPGQGLFKTDVQRALGFNAFFKKLSPEFQEWYTKTYPETVAREAPRFWRKEELNNRWWCNSLVTDHRYQNRGYATAILKTVFRKAVEGGNIIGLGTDTELNVKKYEAMGLRCRGYYILPTPTSKDLTSYVLSREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV48</accession>
    <name>A0A8H5LV48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_001826</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV48"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000014">
        <property type="entry name" value="Related to DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5370584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="616" mass="69162" checksum="0F648A799FB63E56" modified="2022-01-19" version="1">MASQESASLLKRLAGPSSGKAGLAKDQTEINQIIAEASKGSKFYEARHEKRKDKELTERINKLLKAREEALKNVDISKVESNIDRLVAELESQRDLSQIIVHVDMDAFFANVELLFDPSLKGKPFAVGGGVLSTASYEARKYGCRSGMASHIAKKLCPHLILLSSHYDRYSEYSNRIMKIFARYDPNMCPAGTDEAYLNITEYCACNNISAEDCVQEMRKAVFEDTTLTVSAGIAPNKMLAKICSDRNKPNGQFQLEFDARTIIEFMKDLPIRKVPGIGRVSERLLDSIDVRTCGDVFVQRAVISLLDKQFGLGLRSLLQTGLGIASNVVAPYQREDRKSIGVERTFHTISDKEKLFDKLEEIAEELEKDMAESGWAGTTVTLKYKLDTFQVFTRAKSSTRWITKKEDLLAIGKDLLIAELPLSLRLIGLRVTHLKDLKLSESVGIKRFFDSSGNFIKKRKLDHEEERQEEQKETDHWDHEDFNDLAEAEAEMTEPDPHRPRPPTSAPVASSSKVSIRSSEKPRSTIGISSSQQPQESHPEEAGGYECPVCDTKLAEADNEKINAHIDFCLSRSAIQEAQREDTGGSPKPKSKGGWDWFLEEQRTSNKKRKGKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVR8</accession>
    <name>A0A8H5LVR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">signal peptidase I</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_004186</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVR8"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034168930" description="signal peptidase I" evidence="16">
        <location>
            <begin position="18"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="117"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5371347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="745" mass="81076" checksum="E87353D3AD339E33" modified="2022-01-19" version="1">MKAVWWIASLFTSVVLSKPRCRCLYGDSCWPTEEEFTQLQSKLSQPLIRPVPPESACYPKSNPSGNCTDVQANAFDGRWRSDQAGSMQSTNFETFISPNGTIEACYLDATLGFPCQQGSVPPIGVDARRVEDVQAAVKFAADHDLRLVVKSTGHDYLGRSAAKGAFMIWTHHLKNITANSAFVPDGAPESDTYNTLTLQSGVQWFEAYDAAQENGRTIIGGLSAGGSVGAAGGWISGGGHSAFAPQHGLGVDNAIQITIVTASGEHLTANSHINSDLFWAVRGGGGGTYGVLTSVTYRTHEITPLTAVVVASNFSSPAVKKDIFTEYLKLWPGLSDAGWGGYLELSNAVALSSTDLTLLLVAPNVSWADTNTTIDPFFDFVQNAQPDAFATTIPFDGFYSFYQGFFASGEQVGINVELASRLLPRETFDHPEHLADVIMGFQESIQLIHVGGGKVSEIDPDSAGLNPAWRKAIVHMIVGSGWLSGSTVDQIRAVQQKLRDDLAILESLAPGGGAYFNEASLYEINPRHTFFGDHYERLEKIKDTYDPKGLFIVAEGKVLFSPFSLDTDNIMFGRLGIRVFLIQALSIGSTIASPFMFWKGLSLATNTESPLIVVLSGSMEPAFYRGDILLLTNPADKIYKTGDILVYNIPGRDIPIVHRVVESHDFPSDEDSFVESGVQTGRQGVYDSRQMMLTKGDNNPVDDLALYDGLDWLERKHIVGKVGGYLPYVGYASIFLNEAKQRYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWK7</accession>
    <name>A0A8H5LWK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWK7"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="36498" checksum="EE752B27E15E5F71" modified="2022-01-19" version="1">MGLAPRKVGDVPLNPIGFGAMGISIAYGKVDTDEERLKLLDAVYESGCNHWDTADIYGDSEELLGKWFKRTGKRDSIFLATKFGITPQGNRGTPEYVREQCEKSLKGLGVDHIDLFYQHRVDPNTPIETTIAAMAELVKEGKVKYLGISDCTASGLRRAHAVHPISALQVEFSPFWLDIESPQLNLVQTARELGIKIVVYSPLARGLITGQIRSPDDFEPTDFRRTVPKYGKDNFPKILATVEQIAEIGKKHNATPSQVTLAWILAQGDDFLVIPGTKKLKYLQENMAAANVQLSQEEIAKIRKIAEECNLPGGYADWLAAISYVESPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWP8</accession>
    <name>A0A8H5LWP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWP8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="41286" checksum="0C76D8EDAA5E916E" modified="2022-01-19" version="1">MTEQLVCNSADLAQYKKVLSSLLLALAACASPALVPRVDAPAPFNSSLFKDLNVSRGLNYHYYAVPADTGKPTLLFLHGFPSTSYDWRHQVAFFQDKGYGLLVPDMLGYGGTSKPLDPQLYVASLVTRDIIDILDAEGIEQAVVVAHDWGSQTASRLANYFPERFLSYAFLAVGYMTPTFFATPYEENLNLSKAVLGYENFGYWDFFSSEGADQTVLDHFDSFWDILYPNDTVKTITDWSPLGALEAFITNDTRIPPVDYVTPEERAIQMEAIRKGGLAAPLNWYKIVRGTLEGQDDQGIPQENALIHSPVFFGAALRDYISVSAPIFLAGALVSSNSTVTVHEYNSGHWVQMALPDEVNSDLLHWIEGLGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXP5</accession>
    <name>A0A8H5LXP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXP5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="185"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="723" mass="81355" checksum="4248F14EF349DE91" modified="2022-01-19" version="1">MDERSESESEMSRQRVQTWLKARAERCMKLGDPKRKYALKKFWRKPLNGRKKSIRGHGPLKVLTKHVVLNASRFFWFNLDRTTTMSLTLDRVVYFFLHPVKSLSNDHTGAGIDPFYVLTGFIALGIWLVIERERRSRNSPVSFPFRIPVEADPKWDSYKIKDPCLESHLEDQNLMPPALPGRRYITGYDPSSGLHLITALADNEEEIATKIQRAEQAQRTWRKTTFTQRRRVIRSLKKWLVDNQELCARVACRDTGKTLVDAALGEVLTTCSKMEWLIDHGERYLRPDSRKNPLVLCYKDSKVHYDPLGVVTAIVSWNYPLHNAWSPILAGIFAGNAVVLKCSENVIWSSTWFISVIKNCLEVLGHDPELVQLCCCWPEQANALIKNPKIKHITFIGSETVGRKVAIAATDNLTPVTLELGGKDPAVILPDTDLEQWISVWMRGVYQNAGQNCIGIERLIVHTSQFDDLYDLIKDRVEKLRCGSVMSTSDQGYLSPVDVGAMISNNRFDSLEYLIREAEEDGAKIHGGGRYEHVYLDQGYYFKPTIVGLTNNAASITQHELFAPIALLIPYESVDEAVDIANGTRYALGASVFGPDQDLCVKVAKQLECGMVSVNDFAVFYQECGGLMIIAYSQDLPFGGTKASGYGRFGGPEGLRGLTNPKVIVTDRWPTLVQTTIPKVLDYPIRSLSIGLEFTTGLVRFLYAETLRERLGGLVGLVQAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AV48</accession>
    <name>A0A8H5AV48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_019025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000549">
        <property type="protein sequence ID" value="KAF5311539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AV48"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="8">
        <location>
            <begin position="185"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5311539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="306" mass="33496" checksum="AF80F2C3A47C2B30" modified="2022-01-19" version="1">MCLEAVTNVDNFKVTTLLTNSGDETLHLLNDPTSSLISSDANSFRITNSKGASPAFNGAVFKFSPAVAAKMNTPDVITVIPPGQSIKVEHDLSSAYNFTSSGEDVYDIEASNKFFVVDPATLDVTQIYAKQESSHQAKLSGTLSIARRTTSLAKRANFNGCSADQQSNINKAIPAALTYASDARDYLRNHTSSTDRYTHWFGTYNDARRSTILTHFTNMAGRGYNVYTYDCTCPRSRPGVFAYFWRAANTGQDSRAGTLVHESSHFTALAGTRDYAYGHPDCEDRAAVNNADSHEYFAENVNPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BC72</accession>
    <name>A0A8H5BC72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000415">
        <property type="protein sequence ID" value="KAF5320206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BC72"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5320206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="19120" checksum="B0B24B104F33CB96" modified="2022-01-19" version="1">MSDPAITSKKPKKSKKAAKSKPRRIRPHGNVTVRQPGEPILWVFGFRFTREELKLHPQYKVERAPEPPRSFSGRQGLNIPTDPRIGSVSIHVRSSARKHWKRARMDLVVPDETWRTERCLILADNSSSDRISLPSAEQLKAIKEATHASGDPEWYLADDPYIKPEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BCW9</accession>
    <name>A0A8H5BCW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000406">
        <property type="protein sequence ID" value="KAF5320566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BCW9"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034082181" evidence="1">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5320566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="235" mass="26304" checksum="01636F3283A4C8E2" modified="2022-01-19" version="1">MLHNKVLLLLLFFSSRLFIVFSSAERSSFKISVPPSTDVWRTPVTNRFNASTHPLLSSGPIPLKSFNRTRITFSANWTTLFDQGGILLHLTPSKSAKPASTGTSDPGFSDRWLKTGIEFNMDKPFLSTVGTYVYSDWSIVPTSETGGKTTIEVRREVDDTGTSLWVYQLVIRDDGKELQRNPLRQVTWFFAGEDEWLVDVRAMAARPASREDVKGDKNLVVEFEGVEIDVGGVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BJH3</accession>
    <name>A0A8H5BJH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_017077</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000393">
        <property type="protein sequence ID" value="KAF5323633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BJH3"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034552068" description="laccase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="165"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="367"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5323633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="517" mass="55921" checksum="7A851E199ADB468D" modified="2022-01-19" version="1">MSLRSFSTFLLIALTCRSSFAELIGPVADLVISAQTVSPDGFSRTAVLAGNTVIGPTVRGNKNDRFQINVINQLDDDTMLKSTSIHWHGLLQNDGTNWSDGGAFVNQCPVAPGNSFLYDFTATNQAGTFWYHSHLSTQYCDGLRGAIVIYDPNDPYADLYDVDDESTIISLSDWYHAKAETLTFPAPDATLINGLGRFNGGNATELAVITVTKGKRYRMRLINMACDPNYTFSIDQHTMTVIEVDGVNHQKLEDVDQIQIFAGQRYSFILDADQDIGNYWIRANPSIGTQGFAGGINSAILRYVQADATVEPDTPLEIATNPLVEADLVPLENPGAPGQPQVGGVDVAINLAVTFAGQFAVNGATFIPPTVPVLLQILSGAQSANDLLPAGSVYNLPLNSTVELSLPAGAVGGPHPIHLHGHTFDIVRSAGSSTYNYVNPPRRDVVSIGNTGDNVTIRFTTDNAGPWFLHCHIDWHLEAGFAIVFAEGPEQWTSSINPTDQWDQLCPIYDALPASDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRZ8</accession>
    <name>A0A8H5BRZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Novel STAND NTPase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000363">
        <property type="protein sequence ID" value="KAF5328457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRZ8"/>
    <dbReference type="OrthoDB" id="3254135at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="4">
        <location>
            <begin position="214"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="725"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5328457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124061" checksum="33110E6FF9F8CC88" modified="2022-01-19" version="1">MLRAIVICRLSVLTGNPRKKKDVRVASGLSLTHVKETLSVVSSVSKAVGFPPLEGAAEIVKRIVEIVENMGQNKKDCISIPQNIAKFLQDIAEIVQRGSRNKDKLLMKSVQEVENELQTVAKNLEEISERSKIKRFWHATEDGDTIKKCEKIINDCIVKFTAKAAANNWNASEELKQGQENIKKGQEAIKQGQEVMQRALANIAKVHDESSITYDDLERATPSLSKVFFGRDELVAEGVKCLMGTDQTFLAILGAGGIGKTSIALHVNNAQEVKEKYAQASYFLPCEVLPDAKSLLQGLTRRLDIEVKEGESQHKKLEGHLRIHTEPVLFILDNFDTPWNNDQVDVESLLEKLAAFNQISMILTMRGLNGPGAIEWKRLGSASIPPLALESARKVFLTIAGMGELEQENPIIEQILKELDCVPLAITLIAKRAKSVPLESLLRMWQDSKTAMLTQGKADGRLTSVDHSIGLSTRLLNPLEVELLAIISFLPDGVPDWVTNLSQMLAGFERLDQSINTLLEYSLVYSQNLTIKVLAPIREYICMDSSIDITRDIPLIESFYILLLTALSGPLRGRQNQIEPQLMNITKILIEQTKYSPKKHHVEAMNILLDFTKLYPTTVDILENILNNCSELGEQDRVLLQFHRLYMLRWMAKWQEVETEAQRMMINVQNNVRYSAKVLKELGYSYYLQARYDEASGKYTVAKTQFEQIGDQRGVAECMESLGKMLLMQEKYNEAAEMLNKAKDQFEKISDLWGVAQCLQRLADINYMQGKYSEAAEMVNRAKTEFEQNEDQLGAVQCLQSLGKIYQMQGKYSEAAEMLNRAKDEFEQIGNWRGVAQCLRSMGNIKRVQAKYTEAIEMLNRAKYQLEDIGDQLGVAQCLQSLGDIHRMQAKYSEAVKMLNLAKNGFEQIQSQSGLAQCLKTLGEIHFVQAKYSEAAEMMNRAKDQFEQIGNQLRVAQCIQKLGEIHCLQRKYSEAAEMLNRAKDKFEQIGDQYGASDIVYRLATLYRKQGLYQDAKTALEVAISKFKDIGNVSWDIGYCLYEYGLLLQDETKYADARKKFEEARDTFASHGELQDKVEMCDKKLAKLDELEKSVGNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVN3</accession>
    <name>A0A8H5BVN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVN3"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5330081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="137" mass="14816" checksum="F23445E36F3DB17C" modified="2022-01-19" version="1">MTVLLINVAVTSLHYDTSLPDFTGALCSTTTNLVNFNQSRNTQYAPPKHHLTVNDITNAHAPSVPIRRPNNPNVAPPYRNSIAADSETTKKQHPSQRNAQETRKDVIISLSDDLTVPFALTAGLSSLGTSRLVALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BWZ9</accession>
    <name>A0A8H5BWZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000340">
        <property type="protein sequence ID" value="KAF5329917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BWZ9"/>
    <dbReference type="OrthoDB" id="2668396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="275" mass="28248" checksum="64CC4BA5C08A7438" modified="2022-01-19" version="1">MSLVDNQSQSRVANRSPSPPSPTRRRAGAMSLGPAGGSTGNDYSRVRSYSATSVSSPYAQPQPHPSSKGFTPLSVGPTPATPRLANRTLNHQHQPSPYSHSYSSYQNNNTNVVIKKPIGRGYPTASRGVQQGQGQSQGQAILVSSGRTNPPAVIERPGSAPPALLTTPTAHSTATTTLSSSAPTLTSSKPAANRSQPKSQSSIYTLLSRPLPASSRDTIAGIVASMLLSRGDTPSVGRPRRSSALGGMGGCGGNATSGAGAGYVKSGLSRVVFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0N5</accession>
    <name>A0A8H5C0N5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000295">
        <property type="protein sequence ID" value="KAF5332974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0N5"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="2">
        <location>
            <begin position="315"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="492" mass="53402" checksum="6311B8290219A60B" modified="2022-01-19" version="1">MSSTGTARALDPRSLGLPPDFIVVQEANWSQDLSQPAESASSPASVHSSNSGYQYEDDDSGTAVEDGSSTLTGIGSIRITQSDSSSAHATQDNLGRGVVKVEVVVDSSSSEESSISDWFRVCMMRREVRRKAKATLEGETERGKREGKEGHNASGVGIFFTHNVRNHRPTSGNGHYIEIIVTFPHIRTCSELAGSSSSRDSESRLKINNFETNLPGFLHQVDNLAPMMLFRSISLKAGPEAGREDAGADILVESISAKKANFQTSNASIEGCFTVSSYLNLETRNEKIRSSVLFEDHQDLDTNPETNLRGTRRGREGFSQLRMENSNGPISSSIILASPSRISKYQASTDSERGGNFSIQANTTNAPVNITFPIAPPYHNLQLNVSTVLGDVEVQLPETFEGRFDVNVSRPGNAGNPQDVDVVNVNDEANQTVDVDVALIERHSGARRRILEYERQDSTGISGWIFGSGEEEGKFRGEVKVGTSTGKALLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C292</accession>
    <name>A0A8H5C292_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_017432</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C292"/>
    <dbReference type="OrthoDB" id="3172935at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034457611" description="BED-type domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5333840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="866" mass="98628" checksum="7C3808BB698FFD3B" modified="2022-01-19" version="1">MLITTVLLLFLILVLGPPHRRRYRKREQSPSLSTVYEDDGPALQNIPKTPETPTRLRHGQRPQNALEEALATSDDEDENDLHPPNRRSHRTRKGPVQLNPLLDPLQLRMPRGRCRQPDPDPDTPALLQPRPGPAKTPTPRRPHAGAVPPADEELFIQQALDSLSLSSTPSSTPDHSHARSTIRLHPSDITTPITMTPRAVHHNRSAKKTRKKKPKANDVWPFFKLDEHTQRHTCTICSHTASRAGNDPPDSFSANTSTGSLRKHLYTYHLSFWVDTCDSANIDIMAKEARSYVESYHADASANPGQCIPRQAYSPAAFKDAICEFIISNDQAINAIENPKLRAIFLMLKKDLNDSDIRHHHEIRMRIMELWDEHLDNLTLEFEKALGKISFTSDMWTNSNMMPFLAVTAHWIETMTMTNAKDKVELKLRAELIGFHRIPGRHDGKHLGHAMLYIFDRVNLSPKLGYGTLDAAGNNDTALEYIERDLRFRGITWSKRQSCICVNQACQDVIDALTDLSFADDSSPDYDPDVSIRRDLIANLQALIRMIRASSQRRDFFSKCLAYIKTIDLELLRDVKNCWSSVLLMLLHAILLKEAIKWMISLHNDLKKYWMTDDEWDRLEKYAQILQIPHSFQERLSGEKTPTLSFALPGYDVMIAKWENMKDTLPQYASVIDAGIAKLHKYRDHADESDAYTLAMIINPGIKLDWFKRFAPHRLDEARELFLQELMCAWSQLESYTAVNEREQIITLSELSNDDWADAILGLPTKDKQPICHISQALQDEVNGYFSESLLCSSSSDTDTKKRNRIGPELNEALQMLKYTLRQGNSISFTEGTSPEEELATLKELLAEKGDKLEDKGVSIKTLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4K4</accession>
    <name>A0A8H5C4K4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000283">
        <property type="protein sequence ID" value="KAF5333847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4K4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="13376" checksum="FA6A730638200891" modified="2022-01-19" version="1">MPIEMVSGPGVGVMPSIIEGVEGEGEASTSTSRRMDTENQTFNLDDEAEGSPESTSSSESASTTTTTTTTASQPTLSTSTTTTSSSSSSTPTSASTTPSSSSSTPTSASTTTTTTTPSSRNSTPSQLSSQSPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4T9</accession>
    <name>A0A8H5C4T9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4T9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="581" mass="63930" checksum="C5942906D40F7D4B" modified="2022-01-19" version="1">MTTTMARSPDYVPPAFRNMWYSEKGLDVQAETRNRDKCISINHSAMEQQRKLVDISSDSDVENRDSDHHLHVRSTSPSSSTAVNFSTPIAEGEVKGYNFDQNGDTVRTRLPSYAGSEHFAFNAYNLNLASVLGDANLTGILENTQHPNQDTPSSTSANFGLPPRYVDGNVPPASATTNTDLEGKSDDDDEGDDCGSVLPDDEQSLVSNIGDRSNVLTPNIHSNLYATTTDVPPPEGFQSWRPQRAKRAIDPSVIPVVQKFPQLNINAGLSGVYPSHSYFHPLSSYHDAGHYASRSGPIVRPSAYAHARSGFTSASTQPVPHPYAQHPFTGGNWPMADSSHTIPATSYQYGLVPLQSFPVPRYIPYNQPLQYPNSHVGSSSGRGIVSNRMPNVQMPGYPAPFPPYPYSSAHAMQPMPTTMLLPRPSFSASNSTASSSTAVAGPTGRGASSTKKFARCLPKPYSKEKKYIRFKPTDAPTRCLWLKSDGNICNEDITDILTPSDFTRHFRMEFHAISHSEEHPQQLKTRCQWEGCGLGMRLTSLKEHVGRMHFGIKQRCCRCGKEAVSIGHHRCGPDEEEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5J1</accession>
    <name>A0A8H5C5J1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_014800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 12"/>
    <dbReference type="EMBL" id="JAACJM010000238">
        <property type="protein sequence ID" value="KAF5335627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5J1"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5335627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="499" mass="56302" checksum="51DA0C8A211D7256" modified="2022-01-19" version="1">MVPADKLSCEFSERAETVSDISFKSSDPVSVYPDEIPNLDGLCPTRCIRRKLLPRRPGRDASLEQYCTLYTSTSISHDSEAQDDDYAPDTLVLTPITSEGHPLPYYHPRVVHLAFRYLEDSTGSTSDSFGILRIEIIPLPDVEFFLDPNGRIYRTCLALLDTLHRYGWGAMTNYQKRVQHDVLVSRERYQDLYLIMRERHKGLVDTWKEVTDPLKHVFEDIGIATYLILLWKDTFAVGEIEGKHGAKEKYDDEDNPQPWRQWPRPPGGFLDLGCGNGLLTHILVSEGYSGHGIDVRARTSWSSYPEATQKALHVHAFDALSEAGSHPEDSKFFRPNVFIIANHADELTPWTPVLATLYNASGYLSIPCCAWTFDARYSRSKADVFPLPQPGSGSGEQVWQSVDGFARTLALGGESTNSNLSGYSMYRIWLASLSLHCGWEVECDNLRIPSTRNWALTGRKHAPEVPQNVARENVDKIIIDVKQRGTFKARKPEGRDDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6L0</accession>
    <name>A0A8H5C6L0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000237">
        <property type="protein sequence ID" value="KAF5335649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168099" checksum="8BAB6B3A73A58B65" modified="2022-01-19" version="1">MISPRNDNHFPRSSRPPSQESSGAHQHHSLDPEHHAEDQEDSFDDIDMHDGTQSEAQDDPPIDLHDHEDPPIDSRDDDEDNEGEQHPYTPPIDETEPELPEECSSSNIEVIDMAKAFIKCLEDAELDNGDLGQSVLEKLLDPEDFVLQFDPVEDRALILCIKIYLIKDQTVWGYAATIKAIQEAEAFPDEELLSWDQMKCRMKELSGVEAIKHDMCPNTCLAFTGPFTDLDSCPECSSPRQNADGTCKQAFDTVPVGPSIQAMKRNPECAEEMEYFYNRTKECIEEVKRNGFVKDIDDICCGTDIMRAVEDGTIKKGDTILMLSMDGVQLYWNKSSDCWIAAWIVVNFRNDLRYKKVRVIVGCIIPGPNKPKHAESFLFPSLHHVAAINKRGGLPVWDARRDSKYLSNLFILFGLADSPGMIYFSGMVGHNGKNGCRYWCGLIGRHRASASTYYPALAKPDDSDIEGCDHDDIPYNACRPPDSARYKLYLDWVCNSPTQTEYEVHRRESGICKPSIFLDMPEGTILGIPEMLPGDIMHLILNVVDALIGLWRGTFDCHKDDSIDTWVWTVLKGDVWKEHGADVEKSRSDLPGSFDCPPRNPAEKINSGYKCWEWLMYIFGLAPALLYGVLPDEHWDSFCKLVAGFRIFNQRSISKDQLRRGHKLLIDFTEEYEKLYYQRKESQLHFCRQSIHRLSHLGPEAARIGPALCYSQWSMESSIGYFTSMIRQDSTPYANLSALSVRHAQNGAVLAMITSPNTTHIPKFSKPVRNAPGYILCHPTATKPSYMSALELDAFAHYLDTYHPGHGYNRISLNPSIIKWSRLHLRNGEIARSYYKESTMTGYIRKARNVKIVKADGSPEFGEVQYYFRMSFQQPEDMDDDGNSNENDRSVETLAMISRYSNPDANLLRISHGVVMSCSYQGEDDLVVYPASMIEAVVAMVPHSKLSESKMGDAWKERYFVVEKPGLDVADISVPGDSSLSYSQPFVGDLRAGAFSNPEVTSAHAFPSLDRHSLLTQAAQNSTVSLEEEPGTAYRVMQESLLAKNGKLSAKSAELDDLKELIVANLATLSKQVLSLTESVKSLEEKVHAPPSFCSPQHKQEDFPLVTPWYRPSSKDKGESSMEDTSHKAGTTWYIKHEDGSPITAAEADDMRAFMHTILYDLLREGLLAKTWATKPQGTKRPSPASTASRPQSKKPRTSNGKSTTVTNSASSTPPSSSVNTSSTEPMIKPKPSSTSTARKPTPPTTEPTITPTIALTANTSEPPASLPSVAPPNPEPTITPANALEIDVPLPSRVDSPDPIQICEDTSHNKFNDIAFDDNVSLQPPITAEETKSGDIDVTMGEESSDVSIDIDVGKPESFNVDVDMGVPPAYDGVVESPGNQIEFKDVLADLYNKAPPAPLILPPTAAGPSSKGKGKETSDAPAVKKIGRGQNAKGQKLACRPRPDTTNPKMLRKLKYVEELDADRSTDGDFEELWNSMSKEDKQKEEKDAKEATEKAIKKEALENATASSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7L0</accession>
    <name>A0A8H5C7L0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7L0"/>
    <dbReference type="OrthoDB" id="3188871at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="176" mass="18965" checksum="DCB5D5BFCC1BFBD5" modified="2022-01-19" version="1">MTSAIVLPHLDKWAQGHITAITKATTQEEFDSAFDGFVAADPDVDITFNGVKISRQEYKNRLQTEAFRETGAEVVFNGTVQVPGDDGSNVPSPYVGEAGIFYTAILAEGILVLGAPQERQVTSSINIFVKNDPSLKPPTLPGGIRGFFDPRRAFRVNQVFLDRANTASDSSAGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7M7</accession>
    <name>A0A8H5C7M7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000226">
        <property type="protein sequence ID" value="KAF5336649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7M7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="59" mass="6594" checksum="6349C27C01B8BE86" modified="2022-01-19" version="1">MDVDTPESFQAQDHFMDVDSTPIEDSPKLSNSRNSQFETICYSCDCVTDVPMDIDNAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7N7</accession>
    <name>A0A8H5C7N7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000221">
        <property type="protein sequence ID" value="KAF5336780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7N7"/>
    <dbReference type="OrthoDB" id="3036523at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43303" checksum="CAC4BFE152599CA8" modified="2022-01-19" version="1">MAFVGMFLYFKNHANRRLSSEMCKRLERRWKTFNQPLMIVALILNPYERLERFGSESGANTFETNGLIVEVFTQYISGELPPESWTDEEKEKFEEERKRRIAQVSVAYLQYLANTGPFKAWAKVRENWQEMHGDNPIIFWEQYLDDKNVSELAEFAIAILLIVINTAGNERQFSDLKIKKNHLRNRIGLRKLKKLMKIGANLKARQIEDGLKDIRKSCHNYDDDRASQLLTVPRYADLLQNPPGAEDEPATAFNAQRQSRLVRNCSMWRQQVLEWTTQAQEQELADQSDDDSPSLPTRSWLPRSLELLFLEKKTTAEANGTVILESGTRRTRRRVEYNEEILRMELLQLEEEEEMLDDGAKEGSGDEYNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9A6</accession>
    <name>A0A8H5C9A6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000217">
        <property type="protein sequence ID" value="KAF5337489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9A6"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034142002" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19347" checksum="2FA8BA7FA2E1B0E4" modified="2022-01-19" version="1">MFLLKFACTFILSMTLVIGAHSAAVHVDRRATDAEISLYMQAHNSLRTIYNASAVTWNDTLAQYAQNYVNKCIYAHSNPDPYGENIAAGYGSSYGIAKGLQDWANENSTYNYNKPKASHFTQMVWKSSLQLGCAVQTCTLPVLGNHLSTYIVCEYYPKGNVNGRFPANVNQPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9C5</accession>
    <name>A0A8H5C9C5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9C5"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="527" mass="58021" checksum="FF444936421CB85F" modified="2022-01-19" version="1">MHIVVGIHRNEIKRVLETYNLLSERYFTHASPTLFKAGTLNPQLSSRFLLCMKEDYIEGIYDSPSEEVCNDQVSPNCPRPQTDLQPSRLFDHPTQVTGAPLTASITVVPSACLDKEGISCHNETYHLAPELPPGSFRLSPGDRLNSLLDDCPGVGPLFPFKQDEYDLTVDIYNHHYNDRSVRDPDFMDSFATIAMKQHYLIPKNEDGGEFPLPAGLKVCVDGSLEILDDSEPSSPGPSATTSLRDDEDKEDSQSELISFTTPSPSAATAASESLDSDDEYLELIETYRWRNSKIFKLLAVVPSLSIEDCGILSPSVCHNDPCLLWCPHLRPATPPNNACLPPPAPDLTYDDGPICAQDLDLGLPTELDSLSSPSQLHHHLAEHSSETNEPQEADCNDHDHSLGDDYVQEHQPGSDELTPEQVQLYATWEKNSRAEKAKKARDEEDARNVLFSSLHAAQPPTVHSPSPLVNLKRVDSDSDGSSWASTSSGSDSVQWQPVFYAGTWGALQIPVMVPTRTRPIPSLASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGI1</accession>
    <name>A0A8H5CGI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000167">
        <property type="protein sequence ID" value="KAF5341330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGI1"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44857" checksum="8CAADEB9E78DDD88" modified="2022-01-19" version="1">MSPSLLVLTGAHVNRITSSFTPAYLQSLMADVFALVSSQSESNSNNPTSNPTSYMPQRIVFPTENHKVLFMPSRICDMGTTMKIVSVPTNPGDLRGLPASTIVLDQDTGGVKAIVNARMLTALRNAAGSLLSTNLIGPTHPTHIVAFGAGQQILAHLDLHLKAYPESIRSITIINRSMNQRFRDMVSTLRSRHPTSSVVQENLQCLEWTPLSSSTAPSQTETPNSRNVRQALSSASIIITATPSRIPLFPSLWVPDNAHVILIGSYTKEMKEVDRELILRAVSSESSESPRLLVDSVDACLGEAGELLDALDAGLSRNQMMEIGEVILERRRKGLGFDDYCLRQGFEGETRTSSSDASSHDFQNFNGPITLFKSVGVGLQDVAIACAVVDRAEEMRMREAEDDESPSLQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHG0</accession>
    <name>A0A8H5CHG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000166">
        <property type="protein sequence ID" value="KAF5341349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHG0"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5341349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="10722" checksum="0328DA4834955D9D" modified="2022-01-19" version="1">MNKDDILQLLPCLLIVINSAPTVVKLINITNGSIRVARRNSTLKSKRARAINRDFWSGAVRRGDIARIGVYVVEACGIFKIGEIIGRRSLVRYNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ90</accession>
    <name>A0A8H5CJ90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000158">
        <property type="protein sequence ID" value="KAF5342750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ90"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5342750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="201" mass="22029" checksum="79F96020C17B67FC" modified="2022-01-19" version="1">MSPPTLLGCQSLISFRSCDACFILGLSIWTPRRISTMSSRAFLWGSADDGAAEDGALSREGSRGGLSVEAMLGFRTATNNHLQCNPKAYSEFRSPPPPHEEPRSTKDDYFLTTMISINSPPPILRIPTFLRLAFAPQALLRRYANPSSLDNNFGRLALSAEGEDALISPTPGTKPPCRDPSPWRLYGLDGEDGWGLSERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKA0</accession>
    <name>A0A8H5CKA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000144">
        <property type="protein sequence ID" value="KAF5343275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKA0"/>
    <dbReference type="OrthoDB" id="2640446at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="42469" checksum="347CB46900585A31" modified="2022-01-19" version="1">MYPSSSGKKSDQKSGSTSQGGAQRSDKSKGECANAAAPYQKPSDCKKDQKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKVKENASVAVSMPASSSSSQVTTTSTLQLDWVQSISSGDVEMEDSETPVSHHISLPAFTTISDQDHMHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLELRLAGDMQVEVRKDNTRTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVEHNLQFLTSKSQVEGELQNKNQEPLETTEENTNKTPIPQEHEPEPMDVDEDKTIQPDGPRRSTRIREARGLLYNEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQCDAWNLRLLAQPREPYYYFYLWICRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKT0</accession>
    <name>A0A8H5CKT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000137">
        <property type="protein sequence ID" value="KAF5343622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKT0"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="204" mass="20788" checksum="48529D8923F7285D" modified="2022-01-19" version="1">MVSASSLKINNKCDQYVAPSQCTSGQLTLFPHLAPSPFKSPSQAGPSLMSLFLLAKLLAATRANKAMSRAEVNFTPGNSAVAAFINLSNMFGYSVATELTGSGCADYVCNIASGCPVSGPGGSCVSPCCKDFDSCQGASSCPAGGRGDVGGGPGPQANFYKGACPNSYAWGDQDSDEPTQNLGGYCKGDDIEVTLCPGKPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLM2</accession>
    <name>A0A8H5CLM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLM2"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27035" checksum="C9A97E2AE4DD7D2E" modified="2022-01-19" version="1">MRSPVVLVTGASRGIGLAVTSILLSKFNAQVVTLSRTISPELKALSSDNLLALECDVADEKKVIESIHKGIENFHHLDALILNAGVLEPLCRVADDTPLSAWKTHLDINFFSLITAVKVAIPTLRKSELGGRIIFVSSGAAVKGTPGWGPYNAAKAAMNSLCRTLGEEESDVTSVAVRPGVVDTAMQKEIRESGATHMGDGHANFVRLHKDGLLLKPEESGHVLASLALKAPKSLSGQYVSWDAEECKEFRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM75</accession>
    <name>A0A8H5CM75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM75"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="222"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="79941" checksum="0FD1E691ACCFBA26" modified="2022-01-19" version="1">MRLLSTKDFKVKEFFTDIPCYVILSHTWEQEEVTFQDIQNLDVAQSKAGWRKVKNACLRARRYHFDWIWIDSCCINKESSAELSEALNSMYQYYEDAAVCYVYLSDVSGEYHPQNEKSNFRDSRWFRRGWTLQELLAPEFVVFLDKDWERIGTRSSLRDVVSVATTIPVEVFEGRIIGEYSVAQRMSWAAFRETTRPEDQAYCLLGIFGVSMSPIYGEGGAKAFMRLQQEIIRISDDRSIFAWVAAPPTKEEPYSTADTRGLLARSPYEFRMSGDVQASNAELLGNQSSYSFGNNGLHIHLPLNPTSSSSGRSDKDIFLAHLLCQSRRDGSFLTVYLQKTSGHQYVRCYADEVFLTSSLPALDNVRELTVREHLVTGHRLRTSNTSSVAESSMSRYNVELLRSAWDFLCLSSEQEGDNFIFSIINEHTVSVTTRRSFLGGGGIRYKSQKTGDFFDIDFTDREHILKIKDELSVFNSSGEDTLIGKLRSGGYVLIASERRGDLQEKVEIGYCAKDDPEICLWAGPLRLPDLGIIVPSRLSTKSFDDHLQFEGIFPPDPFGRITQEMAYATVFRPHPNDPKECSYPTFRVLTYRYDGSNPKYRIHVAFGLQGSSVWTDLVMQHPSSHETSEDVWKSYLDSGLRAAGKRLCRKASVKAEFEVLLPSRSFSKTKTKTQTATMTAVIQRATNLQMGDYLLRMYKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNJ6</accession>
    <name>A0A8H5CNJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNJ6"/>
    <dbReference type="OrthoDB" id="3230513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="258" mass="28552" checksum="BC24EA1EB7EE052D" modified="2022-01-19" version="1">MVQSPPLRRDMSHRKPVPVYVPSPRSSPDLPQLPINPKISDAHQAHTVTLCASESELPEILLSTPKDASDSSTLNRPTENAESSSYGSVYSQSTTARLKHGLPQTYRPPTPPLASNKKRKIPEDNRDFLTVPPVTQQGVRDSYFPPVPGFRTQPSPPGSPQTLSPQQSFQTEKTLVSTHSAPEFRYSTWQSTRPNQTTDQWHDLPVLPMHVIKPRRGSGSIESSSSKAASLPSARKWWLHKKWSSLRSAVHGCLSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP38</accession>
    <name>A0A8H5CP38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP38"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38024" checksum="619930682A4E9B0E" modified="2022-01-19" version="1">MLPAPVVLLPKRRHFRRNSNTEGAFRRRKLQDLLLSRARITNLAFFLLAFAFSISIFINLKHLLTSQSSPLPQSILSTISRENTHLDHLIVVPCHAVWLGGASEDRNLERLWLLEPYQQGSGRLKAFFQHILKAAQLALEDTRSLVIFSGGQTRPAATITEGESYLQLALQADVFHISFSSVIRATSENYALDSFQNLLFSIARFHEYTGRYPQKITVVGYEMKRRRFTELHREAIRWPTDRFFYIGIDPDDGPEERANAMDGELQNGFIPYTKDLYGCHTQLVFKRLLRNPHLRFHSYYTSSPELRELLDWCPEDMDALFHQKLPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPZ0</accession>
    <name>A0A8H5CPZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPZ0"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="39"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="735"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="886" mass="95438" checksum="921800DC57956B63" modified="2022-01-19" version="1">MDVDSPFLQYFDTDSVNFPWRESRPAEIDQRRAMLGDLLLYDVLLQNGDIHEPDLIYPPRDVSGLHRLLEAIATSTYDDLKKDCLIYYLLKWHMDGRESRFQQERCIIPQFAKLADAYWCLDTGLNVAYAISLLSDCRLNTDYASKIMQAIISAPSTDPYPSYHPLIVKYIRTAKPLLTEPDDLDTYMISLATSSSTLTDAWQFQRSFSEQDPTRTRLLKRLLQWCVMPEPRPEALAHLLILPLSPFEKGVLHSYAASSPPKNPSDPTPSEFLSSSALGLAVFQNLACTRLVQTGDYADAIKLHRKFVASSLGSSAAVVNIISDRKALIESVYASLPAVERTLLDMELEGAPMSTLTTSGMGMGNIAMSSSWEDPKAPGPTPAVSVNGGPDSRRKSGIGAGLVNGIKPSSGSQLPSSTSNPLFGNSVLGSSTSTAAAPPIISSRMNTSIVGATRFDGLPILPATSSITTTMIPASSGFSTNSGPRKSISGLPAPGLGASSSFSSSTSAFNTNPLSFSSSSKKPNAFYKPPFAENSRVDNDDFNPFASEKTRARASGSISPERPEREKAVFQSQRERRRRELRSDEDEDDMQTDADQRMDTDDSPTGLDYSIFLKKGQNQTQTHDRDIELGNLDQGSGLGLGKRAFGASISSSKEPAGTRRSGGFGSSAVTGNGSLDTSMRLSTSGKLPGSFMDEDDEDDEENTVQEPETISAKSMPPPPVPEPKTRGLRTSPRKSTVGNSISASSGSGSVSAKASSSKKAATSASAVSGTGTSKVRKSTRKSTAVDSREQLKRSIPGAMFDEDEDESDVQSEVASDAGQEEEDDVAPLRNTSARRNLRKTGSGIKEKMETDEGVSTRRRSTRLSSASNLGDAGTKKSTRSAGKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQJ0</accession>
    <name>A0A8H5CQJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQJ0"/>
    <dbReference type="OrthoDB" id="3038990at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="399" mass="43451" checksum="47A6CB32233BFDDB" modified="2022-01-19" version="1">MESPGNETQWPILNPLTPDIFFPPNILVAALAATYLVVGVTGMFLWDMLSHVGMDWRLLFEYRVGLPTFVYFLSRISTMAYLIVQTIFVTAPLPDCNKAVFAQLGCYFVAAASTSFLFFLRIRAIYNGARFVIIVYSLLWLLNLGCYILTFFTVGGMNIGISAKLYTSHNISVNAGTTTERRSWRNGFAIVRDVKQFFSGNNLPRLSRTLLKDGQVYYLVVFLTTALIILLNFTPSPAPAFHLMTITPHIALANSMAGYVYRNVRFGIIREGELSNAIGSVPVSINPSLPDFRVPGFGGVGSHVNGRSGSGTAGSDIGTHGNGNVNRNGSNHGHGHGHDSGYGSPYVGSAIGHARTRSRSGSMGTRYTGTYAAGRHPIQASSLPRKVSFSDSIPDFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS14</accession>
    <name>A0A8H5CS14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_010160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS14"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="406"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="742"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="826"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5346937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112344" checksum="3AD838B3B1B2411A" modified="2022-01-19" version="1">MAPRTRSSQRIQQSPSPTATTASTNQSPLFSSTRASTVATRDTSVVSDVQDTTVKTGRATRSKTDKKRAATPSDEEEEESVVKPAPKRRAVSGKPYVEVKTAKKGANKGKEKALLPAAYNTKNKITKRPVPATSEDEAVSDSELEYQDFDESDSSGSEFVDSEDEEAVIEVDFDDDEADDSEDEVPLRVATRKSPTKKKTQTAYQSDDEDMILQAAIELSRRGEPETEGAGSSSGNTRSHINPEAVRRAEAAERRLAQGNSVVDDSAMDDLELRSLESGSEDEAPKVKGKGKGKVASQQKFMTVAEMRRARRRERQEATALRRATKKEERELVRKLGRKLTHAERTTLQLHKHHPELSNVWGDLEANIKIIAPVKAEQPKNIKLTLLPFQLEGLYWMKKQEQGVWRGGMLADEMGMGKTIQIISLLVSDNKKPTLVVAPTVAIMQWKNEIETHTDGMKVCVWHGSSRESNVKELSKHDVVLTTYAVVESSFRKQESGFKRSGKIIKEKSPLHLIHWHRIILDEAHNIKERSTNTAKAVFEMSAEYRWCLSGTPLQNRVGELYSLIRFLGGDPFSYYFCKKCDCKSLHWKFSDKRTCDDCGHSPMNHTCLWNNEILTPIQKHGMTGPGKIAFKKLKILLDRMMLRRTKIQRADDLGLPPRTVVVRKDYLSPEEKELYLSLFSDAKRQFNTYLDHGTVLNNYSNIFSLLTRMRQMACHPDLVLRSKTNTNKFLTDDNVGEATVCRICNDIAEDAIQSKCRHIFDRECIKQYLNTAIEQNPACPVCHVMLTIDLEAPALDLEANVPNARQGILGRLSLDKWRSSTKIEALVEELSNLRNQDATTKSLVFSQFVNFLDLIAYRLQKAGFTVGVALSRLSTFLVLLSSSPGVIADDASVVNNVDVTVFLVSLKAGGVALNLTEASRVYLMDPWWNPAVEFQAMDRIHRLGQRRPVKAIKLVVEDSIESRIVQLQEKKSAMIDATLSPDDSAMGRLTPEDLSFLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUP0</accession>
    <name>A0A8H5CUP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000087">
        <property type="protein sequence ID" value="KAF5348210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUP0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="90" mass="10409" checksum="037280A3F42492F7" modified="2022-01-19" version="1">MKHEEKALEDVRLCPAFDCLLPELLVSFVAGPGITNLFKLLDRYGNFYVLGAANVKLLVESRKVLKRRWVVLMDWTFAVVSNPPWIREYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVE7</accession>
    <name>A0A8H5CVE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI ethanolamine phosphate transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVE7"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5348739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="110974" checksum="E0CFA0518CFF3C61" modified="2022-01-19" version="1">MSRGLSLLLLWIFFVHLAGIYIFKNGFLLTRLALTEFTTCLDDSCITSPTHRRAVFLIIDALRFDFLSPHPPSPPSPYHHNVLTLPAKLTAAHPRKSFIFNAYADPPTTTLQRIKGLTTGSLPTFVDLGNNFGGSSIAEDSIVKQLTLHGKQAAFMGDDTWMSVFPDSFHPNMTHPYDSFNVEDLHTVDEGVITHLFPLLEDKSKPFDFLIGHFLGVDHVGHRVGPDHPSMKAKLQQMNDVLTQVVALLDEETLLVVLGDHGMDRSGDHGGDEIFETSSAMWIYSKGPDLTHTEPSVPSELLQYTTFPGSDRPHRSIQQIDVLPTISLLLGLPIPFNNLGTVIPELFWRDATGNELLHALELNAAQIHEYLQAYRSSSSGGELDEAWQDLESAWAATRLTDLKFEQKLTSVYDFTRGALSACRSIWAQFNPLLMILGLILLGVGLLATWALYSNMSTLDYRWNDWLENKLQGCLRGIAVGATTGVLLFLGLGPYLQGMDALDCIIFAAPFASCIAVLISAPPKVSLSGVPLILLLHALSFLSNSFTFWEDRIMTFLTVSSVLPFALTGFTAPTVRLRRRILGFSLLFAVCIRLMAISTICREEQQPYCHVTFYSSSSIPVAPSIILLIVLPATIAIPVFLRSFLSISRSHVGLASFFLPLILAPTLLSGATFWMLEWMDTTEYLGNEWTPVLRTSRTWLARFCFFTATVLGGVLWYMVPLCIFVDKSGTGGSDQKGKRQIKVIGFANAFGSPYLLFWSISFALVYVTTQMTGQVVLALFALALVSYLEVVDSTRDVKMLETTFASQPSSLMDLNAETNSPPIRFNEIVPLALLGLHTFYTTGHQSTISSIQWKSGFVLTPTVTYPFSPLTVLLNSFGPLFVVGLATPLLALWNRSPKSTPAANPRTSSEWTEQVVLGAKEKGESGLAAMGVMSYYATLMFGSAVSAAILRRHLMVWKVFAPRFMAGVLGVLVVDVAAIIGVSIGVERITAKVNQAFNGAFKSHGAPVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVY4</accession>
    <name>A0A8H5CVY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVY4"/>
    <dbReference type="OrthoDB" id="3026831at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="622" mass="69813" checksum="54D7BB637B9B916A" modified="2022-01-19" version="1">MAASSEPNAASFFQHSHQISVVNSTFNMVAGNMDVAHYRDHERGTRRSSVLSRLFSKISEVIPWSTERSPVVNRCTQRIVSRNNIKLLDQLSSERQYRIHSAKYKQRLVLVKVFQGTQAKKNFKEEKKQNQRLLHPSLLKMIGVSPFTTESPFIVYNFAPARGSVESRLASVLEKDLSDILLLGCKIVSELAIGLDYLSSEGARAGSSSKKSIEIFITDDDVLKIAPDFGSLLIEDGGRHDGSNIDPLWGLFNDLCIKTFKQATCILYPDVRNREVSSTITEVSSAPDPDPATDVLGDTESLTSGVSSNLHFKELEGSPSPRRELLWRESSGGSQSVHAVAEHYREFWEHLNLTVGQSYHSYTMPRKRAARPLRTVVHRCQGYRKEEIMLTSDVSENAIVSHFIPSLYERCPVCKEIVEEEEFRCACGGNDDGITPTIKCSTCGIRQHSSCVHVMIKQVRVTAPTSSSNLNLLFMCSFCIRSPNPRNPNEDASEGTRIHSFNPEVESEEGCTPAEDQEHAPITTNDVTAEREHLIRHLMRIRDLRRNFLEQYNKGHQVEQSAQLPTSESSAAAWLRPSVLLPFTAMEQFREFEARRKLQPLRPANATHLHPPDTATHVSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CX28</accession>
    <name>A0A8H5CX28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CX28"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5348638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="269" mass="29290" checksum="9CED1D0819274685" modified="2022-01-19" version="1">MATQGKSGSEGDDVPAKATVISLPSISSDVEGLVSNAALEKRVIRRIDLRMLPLLGLLYSLALIDRTNLGVARVLGMGKDLAGFFPALVFIITTWYTKFEVQTRLAAFYLVSILIGGFSAIFAYALSFLAGVGNLGGWSWVFIIEGALTIIFGIVAYLYLPEFPDNNDFLTPEETELVLRRIEIDRADSIPDGITAQKVLLHLSDWKVWAYVILSGMGWDLAHSLLLASNNVVSHSKRAVTTAVIISFGGIGGIIATTIFREQDYPSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0F8</accession>
    <name>A0A8H5D0F8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0F8"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="188"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5351364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="473" mass="51226" checksum="EDFF8F358E80DBE3" modified="2022-01-19" version="1">MTVPVAPVDLEVSRPKDVGLLAMEVYFPRRCISEADLEDFDGVSKGKYTIGLGQEYMAWPDDREDINSFALNAVSGLLQKYNIDPKSIGRIDVGTETIIDKSKSVKTTLMDLFAESGNYDIEGIDSKNACYGSTAALFNAINWVESSSWDGRNAIVVAGDIAVYAEGAARPAGGAGAVAMLIGPNAPVVFEPIHGSYMCNTYDFYKPNLSSEYPEVDGPVSVVTYTGALDKAYTVYREKAARLAKKAAINGHASGDTSFSIDSVDYAIFHSPYGKQAVKGHARVLYNDFLANPSAPAFANLPEADAETYRTLSPSASLSDKKLEKTFITLGKKSFAEKVDPAMACSKRLGNMYTGSLYGCLASLLSSVEAQTLKGKRVSLYAFGSGCAASWFTAKIKGDVTEINQKMNLLKRLADMKVVAPQDFVDALALREKNHDAKDYVPEGSIDNIWPGAYYLESVDGKFRRKYAKAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7Y6</accession>
    <name>A0A8H5D7Y6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7Y6"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5355307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="797" mass="88596" checksum="2A8BD205BD963549" modified="2022-01-19" version="1">MASSSPYDSGRSLAAPARNKRRGAALSCAECRAVVFFRAGTSASYVLPTLLPNSDPCTTATASRKAAELFVQMIGELATRVRQLEDALSESHRQTSMQPHPLLSDQLLQIKRPLERERLDVPPIKEEKPENADTIDAMGSLSISHGGRSTFFGQTANSWYLLRNEEGSDEEKPVLNIHPSMPSDLPWLAHAFPFSASVQRSAEDVRVAINGSLPSVTVARRLCDVYYRHAAWMYTPISDKDFNDTIFQPLYSPAPYQEPVGCHGMSVFYMILALGTLVDLDRPSHSTEAAQYYQLARAALAVDPVFDQQSIPAIQALLLMCHYLFWEDVDGSRWIIMGMVVKLAQSVGLHRDSGKWKLDPDETYRRRCLLWEIFTYDSWQSLTFGRPPSFSLAHIDSQRPHETVKNSQGEVEMSFAAWKHGFCAECLSVVHDEVFGAHPPSYRTIQEMDKKVRTHYTPPSLQVPGFGGARLSAGGVEQTPTEVTMQRYTAFAIKEISLFYMHRGFFARALEDNPQDPMASKYAPSVLAAYTSACSFVGLIGSLWKQHPALTERMWFLFTHVFSCAIVLGSIAAKSQMAIAPSALSHLDSSFNLFNSTSETARKNRILPVLEKLRERARIALSTPRSPQTMEPGPRSPPIKKEEEGLAALGGMTRLVPRKSSSTPSTPSYSSSSPISQSASPPPLRTTSNGSSYQPMTGNGTNWSTYPSQTADYNVEQYSGQHYSQGSVQPESPTSYDMHQAQHLTLDAMPEYYGYSNIPSYQSEYSQYNSAMSGSNDFLMPSDVTDSWHNLMAQYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DAL8</accession>
    <name>A0A8H5DAL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_006039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DAL8"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="491"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5355327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="581" mass="64187" checksum="FB99121FCF452294" modified="2022-01-19" version="1">MSGLSSSLQGLLDQFRDLCLSFDVNSPKKRTNLAGVLDAIAIELASSEEARKHIGSDDTGLWTNISKLWRSLARAQLTFWDGDSDGDDEDRQDGSTSAQGCSFSQFCVSLSRFIRNLVAAVPANQNKAFESEPDIRRLLHYYTSWTSMEDQDAVLAARILTQTLANIITGNNALMSTLWETYLNLPEDQVVLMRLMLSRDDRTLVAAMTLVKNCIADSRTRAKMLTRTTIGSRLCVSLLDNMVKLYEADEGSDGGKAFDTGYEIFTRIFEAGLLPELYSRLNIEGEIVTPHQTTLLKLLDSYLQSTPVLTSSPNPKVKTTHVKLTPMLTKCFFGLSSYAQTAIRRALRPSEAELVSPTASPISLPTPHSHNIFLPAELDVMLPKVCEAIVLVTQCMVSIILASEDARVSPDPELGPVESLQDYFNNQNSSDGVGLVENLIGLLRLLDRFLPRINFGKPVETPRNTSSRSHEDCSTSQPSPQQPGSLGFSYLKRDLVRLLGILCHERLAVQDRVRSCSGIEVVLNLCVVDERNPYLREHAIFALHNLLEGNAANQAVVDEIKPLGQWDENGVLVDSPGATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ERH7</accession>
    <name>A0A8H5ERH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000622">
        <property type="protein sequence ID" value="KAF5309641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ERH7"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5309641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="218" mass="24480" checksum="F8C207DE1B576E16" modified="2022-01-19" version="1">MHSALQIPEILDQIISHLEKDDQKRCAPVCQLWSEVALDHIWRRIVYYSNLKKLSSAAKEINTERPASHTSNSPLTVKALNRLKLKYYARIRTLDLGYSGSWVVLRELMSNSGLTSTLFPNLQCLDCQDQIFDEEFSILILHSGIKSFSVWCSDGLSDILHLTQTITDTNAQPHFLVDIPSSTSGNMPGPLATLLENLTSLEHAGNTSFKDISPILWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EVU5</accession>
    <name>A0A8H5EVU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_018179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000509">
        <property type="protein sequence ID" value="KAF5314217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EVU5"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="946"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5314217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112447" checksum="35CC5BDEA1C87206" modified="2022-01-19" version="1">MAHQSPMISIPRKSTDEVDWTTPIRNIIAQSYGESPDNYATECATLQRCRQDAVRGAGSDTTARDLLYKYFGQLELLELRFSEIRVQFPWRDAFTNKLITQTSIAYEKASILFQIAATHSAIASSQSRSDPEGIKRAFYFFRTCAGMLTYINENFLHAPSTDLSREVVKFLVSIILAQATEVFFEKCTEEKKGAALVSKIGSQAAYMYTTLTEEVKEFMGKGIFERNWITLIQVKAKYFSSLSQYYRALADSAANKHGDALARLILAETHAKEAHRLASSFSASFTYATCPTLPADAGTSISERTKAHLALVSDKKAEAQRENDLIYNAIIPAAEALPTIDKTAVATPIPIQEVYGTPEVQKTIGQDIFLRLVPLSVHESASVYSEEKAKLVRGEVEKAEGAEGEVRSALESMGVKAGLVRFRVMAEGEMGSEEEVPVDVRRWKEDITLMEEREPVEGIMRELNRLKENVKRELDDSARDLEIESRECEMMRVKYDHRWEQDPSSGLTKDLRTDLKSHYGSLEAASKSDQQVIALWDSVKGDIAILMSPEVENVFRASTERSSVERSKIGQLVSEIDERLGRLNKISRERNEVLKDLKDKIQSDDVSHLLLLNRRNTGVEPALFAAELEKFRPYQQRLAATIQHQNVAIQEISSFWKTLRDTAGRGAGARKWEEREKKKKDTVRRFSKARDGYMEVKDGLAKGLHFYNELTQLTSSLRHNVRTFVTRRAAERESLASKLEVEKRLSAASSPPPVAAKPPIPPPPSASDLTSSFGSMNLQGTPPISPAPSVSSPPPPQLQHNRQGSLYSQPQTPVGSVPPPPSQYNPSPGPAPSSYSPALALPPPPPQPHQSSYMSPPPPPPQQQSYQSFSSPSPPQNDPYASLGMFNPSSNSSASAPPPPPPQQPQFTQQYPSYMPSVPSAPPSAPPPPQQQYNQYHYQPQQQQHQPPPQQQYGFPPPPAPSQQGYRGYGYGTPPPQGGTPQHQHQQQPTNGYPGFPPPPSQGYDGYNYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EW52</accession>
    <name>A0A8H5EW52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_019062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000500">
        <property type="protein sequence ID" value="KAF5314800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EW52"/>
    <dbReference type="OrthoDB" id="2654453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5314800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="449" mass="48458" checksum="910F429EC4FCC3AB" modified="2022-01-19" version="1">MSDALGEIIITRTSLAPGHQVGERTITRRGGRVQILEKEFAVSNSSMAPYSFTTKPDTKTRKSTKGKYTLHALLDGHYGEVACIAAHPLGSHVASGGRDGTHIWNLQEKKLLGSPAGAGDRGVTTALAWMIRPDDTDDGLAFGTDDGYLSIWRRSRKEQDFAEVYCNRLEGGEDGQEIAAMAFDATSGQLAIVHRSEIVHRFVVGPLMRLTVVKSTRIKNHWPQAVAFGQTAARGPEIWSFGREDGEINIIDAGGKVTVTKTTGVLERGGAAISVKDDAYILDDTSQGVALYKLSGSERVKTFAVETNERRSRNVCFHDGGKAIVTGSDHGDVYVFDRRTGEVNDIIHVGCKTGSNRSRQWCLTLTTDDGDGGSTDDNSWKIGREDRQNGSSSMGEKDACVATGGSTPGQAPPRTLRVASDLCTAVCSFRLAKPAAGRLYRKHANGWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F0A2</accession>
    <name>A0A8H5F0A2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000440">
        <property type="protein sequence ID" value="KAF5318974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F0A2"/>
    <dbReference type="OrthoDB" id="3267566at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5318974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12475" checksum="1CCB82EE26AF3308" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKVTGRKIDANALIDSGAEGIIINGQFAQKHQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDGEAYHEEKAEFYVTDIGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4F4</accession>
    <name>A0A8H5F4F4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000396">
        <property type="protein sequence ID" value="KAF5323202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4F4"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5323202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="297" mass="34104" checksum="808F10B47ED6F24D" modified="2022-01-19" version="1">MAISVRTRRLLSYALDWSMAIVIALFSNFYLQRFQQMPDFDLTDTSIQYSVRKQTIPNLLLVLLLTLPYILIVVGHFVFSYKKWWDLHSALLGLTLGFSVSGTLSQIVRISAGRPRPDFIARCNPSPDIVNAPVFGLANVTICQETDFTFLQDGMRSFFSGHAILSAFGFGYLSLYLAGKLHIFDSNAHTYKMWIVATPIVLAIWICETRVADRRHHWQDVTTGFFLGILIAYVAYRQFFPHLADQDSHLCYPPRFEENDRRKGAVSQDNREWFPLSGLEATPFQPEHDRRENDNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9Q4</accession>
    <name>A0A8H5F9Q4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000353">
        <property type="protein sequence ID" value="KAF5328931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9Q4"/>
    <dbReference type="OrthoDB" id="3064017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="325"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5328931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="64648" checksum="4B74228CC5344174" modified="2022-01-19" version="1">MDFSAADFAQEQVPVQGRGQRAAQPTGRLLTHQQELAKNAETAKRRAATLAHNKQARQHPAMSMNAPLSDSLSNGLQLNTAALAQALLANPDMLNLLQSHMAQPDMETLLSFNGDDQNTHADNSDQLSNSHDDTTLLPASSTISSLSSPIEDCGQDTDTADTVANVSEISSDINSQPVIMTSATPTQRMPLRRVNANGLTPTPKPASNVLALAPTPASTPTSMHGTPGPARVHCGRRLVYQSHSVTPDFSSLFTADEVADKENEVSTPLLKRKAQDKGPPDSDDDPSGDVVITDGGNEPAKKKVKVKDAMKLLTSARQRLLDIAFVFFRHLMLHRTPWVKEKSEQADAMALGAWQLALNFLIDRCNYSDQAAQPTEVELNIIKQQLAQYRGEIKDIARGFIGAPHGPAFRFVTPHTIENQNINRALVVELKSKEHSFIFKNRNPAIGEAKVYFGSPIIDCVVNGVWFNKGLKSEGIREGFFPEQIIPIPALALILTAIEFCIDEWQDGMQKPGKFSMDIYSSRYDSHLACLQRWDTYSITSGNNESETRRKQLYMNGRALTGITAQEHAASGAPAANFTADDFAADSALLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLH3</accession>
    <name>A0A8H5FLH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLH3"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034060009" description="Laccase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="164"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="380"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5341605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58598" checksum="F7DDEBEAB91026D4" modified="2022-01-19" version="1">MLRSLRAFAFLAALLQLAPFTSAENKTITLDIRNADVSPDGFLRSAVTAGGTFPGTPILLNKGDRVNITVNNQLTDSNMRRSTSIHWHGFFQAHTSYADGPAFVNQCPIAPGDSFSYAFDTAGQTGSYWYHSHLSTQYCDGLRGAFVVYDPEDPHKELYQVDDESTIITLADWYHAFAPDAQDTYFQTKTVPTPNATLINGLGKYASDQGSYAIINVVQNKTYRFRLISLSCRPFFTFSIDNHEFKAIELDGVSHVPTNLVQKADVYAAQRVSIVMNASQPIGNYWIRALPQPANFGDSAKLLSKAILRYAGAPDEEPQTSDDPDGVKMDDTKMRPIDSEGPGKYGSGKADKTFRFNISMGPPDDPQAVAPFFEINNISYISPTVPVLLQIMSGAADPADFLPSEQVNIIEPGDIVDIELTGGGTHPFHLHGHNFDVVQTVNGINYTSAPRRDVFPLLQPNNSLITTFRFKADNPGAWFLHCHIDWHLEAGLAVVFAESPKKNLDGPDKQIIPDAWKELCPIYDDLDPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLK3</accession>
    <name>A0A8H5FLK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000169">
        <property type="protein sequence ID" value="KAF5341279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLK3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5341279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="88" mass="9870" checksum="39DA3538B46C6523" modified="2022-01-19" version="1">MRSLCSPAPPLLLTPHHLGFGYTYTSIFYSLYSMPLGVIEAAFPETAKPIARYGACNSERDRTVGTREFERLGKTHTWPKDTSFHGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMX1</accession>
    <name>A0A8H5FMX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000158">
        <property type="protein sequence ID" value="KAF5342749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMX1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="505" mass="58846" checksum="952F415D1B08FD3F" modified="2022-01-19" version="1">MELQQESWQQQLDQAEAQKRKIEDQYKDLEDHINRYQKEQELKSKEEKITLARRTDQLKIDKLDEQLRECEELESSTGRSYEGENTRLKAEVAGLCEELQELQVYKLNAEQTEAESANLQNKRQEFEELRARYKAENEKHAANLLSAKTDLAAAKEEKSKLLEERDRVQGGFNNLRDEKKKLREANDTLRENIGSVTKDRDGLQTSLSSHKLRLTALEKDRTEAIGNARQSELDSKNAKEELAKVQGLHTKAQDEKKLLQQNKDTLQKETVDLRSEKSKLKSLNSSLRQSEARAQDDLKKTQEERDGLKADLAKLREEKDKLLDDLKEVEAAMDKLKDDLMKANEDKELMEIDADLRADEDVTMNELKARITDLENDLRVSRLTHGHSEETIVGLNEEVDRLNSMVDKLNEENEKEWEEHDVEEKRLDKENDELTAEIAQLRQKQQETEMENQRLSTVNEKLHEKSENDKAKLEKENEKLKTTLRELKTEKEKAESDRDIALNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNL3</accession>
    <name>A0A8H5FNL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNL3"/>
    <dbReference type="OrthoDB" id="3251511at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="319" mass="34511" checksum="51B013F476494D77" modified="2022-01-19" version="1">MPVRESRSPPILTLQLGPARMDTHTAIPIPIDPALLALSSPARSMRSDDSADHMLPQAEASSSDPASGPVHTAKSRKRLSPVSVKPPNYKKLKKSELQSLCREKGLPEDGRKETLIERLKGQNASITTLTIPMPAPRTSITHLSTTAAVVTPSGSDAEYAASINADQILDDVRILEGSFEEGYRGTSVGQTQEDEEGGTESDSDDENEVEGSSVNSSVPFSPEQVDAAIMNSRRKSGRRTEQSVLNQWKKWVVGAIEAGIIPDDIVDAHHTIQFMQYQSNRQLFTKRGIPKPGNSCLSSIVLAEEKHDHAGTSPRPTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP05</accession>
    <name>A0A8H5FP05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP05"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5344290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="475" mass="50296" checksum="11F30BEB4CBC8133" modified="2022-01-19" version="1">MARSRQGPPCTIVIKLGTSSIVHEKTHQPLLSVLSSIVETVVNLRSEGHKVVLVSSGAIGVGLQRMNLPAKPKSVSGKQALAAIGQGRLIALWDDLFGHLGQPIGQVLLTRGDISDVCLGYIYGLWQNSLTCFALLVSVSAISELLSMGVVPIVNENDTVSVSEIKFGDNDTLSAITSSMIHADYLFLLTDVDGLYTANPRKDPSAKQIEEVTSISAIRSQVSTTTLGSSLGTGGMETKIIAAEIATGAGVTTIITSSKRPENVFSIIEYHNSLKMPSPQDHSPGDESPSSLPRPPHTVFTPSPTPMKDLKSWTSHTLHPSGSVVIDSGAHRVLSKRESGGRLLSAGVVGVVGAFASGQAVRVVIRKPVNGTVVEVASAHSTRPNSPIPGHVSTKPLSRSGSSGDLSRDELRNENNAETEQFTDEDVVEVGRGLANYNSAQISKVQGLNSSFLPQMLGYADSEYVVENITIRTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPQ8</accession>
    <name>A0A8H5FPQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPQ8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034400698" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="61" mass="6383" checksum="80E2423D0538544B" modified="2022-01-19" version="1">MQFKSSIILVPLLLVLTTLASPVPERPSVQVSVPVEENTDVNTGAAAAVEGRGGCGRWACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPU7</accession>
    <name>A0A8H5FPU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPU7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="83" mass="9396" checksum="44ECBD13A98BADDF" modified="2022-01-19" version="1">MLVGMIMGISGKGFGFEGVVVNWSLLQDSGHVRRSTSLATLSSRVFLGKVWNLNRFDFYLTSISDWTCLLKVIRERAKVRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSI6</accession>
    <name>A0A8H5FSI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015058</name>
        <name evidence="1" type="ORF">D9758_016803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000166">
        <property type="protein sequence ID" value="KAF5341344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSI6"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5341344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="159" mass="17076" checksum="FA30272FD90B0D51" modified="2022-01-19" version="1">MVGPANLSPPSVATVRSAYETMWARAINRDFWFGAVRSGDIARIGMYAMETYGIFKMLPSAHTIHTNALPAMAISSPRIPHVVLSSFGVDTIPPDYHTLLSTTREVLMVPVTLTLMPMRMNEEEDEEDGNGVDLTGVTGLGVVVLGVGVGVGDWIGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT30</accession>
    <name>A0A8H5FT30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT30"/>
    <dbReference type="OrthoDB" id="3358963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="839" mass="92453" checksum="8539B085271719DE" modified="2022-01-19" version="1">MAPARTQRVHSHDLPADHVANPDLFIDPMLGSPLAIYIEKDVNDRDSLCTLVTKNGGSISQSYSGVPYIIVDPLKPSGQNLYRQYATKRGKIVLSYQWINECIEAGQLHTFHANWAGCKVTGNETASPIPAEIFSQPQTQPSPSTTVPDSHSQETVDVDPTSHQPQPQPHQPLAQIPPPPPPPQPIHPQVLHPTTVQELVQFQYPTMYGPTPIAVPGVPVSVPVSPSRSHLHTHAHTHPHPPQTWQASSIAPSQTQHQHIAPSQILHRATTYREDAWDGGYDHTHAHTHEHHAHTHPHTHPHTHTHAHEDDLNAAAGAYDYTRYREEEQTWVAQPQYYDPTAYDEAYNQSTAYIEESSDPSPQPAAATITVSASGAGSSGTGTASGAGAGDGAAPSTSTSIHEEQSEPPEKPRGRKRGRAAQTPAPPASSLVANRYPPARSPTPPTRVVKSTYGGNLFTAEDVEYLKKYIVYCREQGLVLSLREICERIAVKAPHHTFYSWRRYCNKKQIRLPGYVMASTEPNRGQSDSDVVASQGHGPGQDDTDVEMGVGVNEVDGRGHGHGRVSRHSQPHPHPNGPHHPHPHPHLHPPVAPHDIDLDPPQPQPQVGVQGPGQGQSQSQAQAQAVQSGLGPGPGPGSRGGPRQGQGTIQPLQPQHQPEDLDSHPRSQSQIPSQTQAQNDNQTQTQTQSQRTNSRIIRNRNRSPTPPRALYRSTTGKGVAFTDQDVTFLKRFMEYRKAQGKLDMVAFWKDVAAKAPHHSRASWMKYWRRHKHELDPSDTDDPPPQAPEKKMRYSREDDVLLAQYFRTKPEGTSDKIFQAFGRLVGVDLSLIFPFCYSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU54</accession>
    <name>A0A8H5FU54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU54"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5349840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="560" mass="62851" checksum="84A1631358D66EAD" modified="2022-01-19" version="1">MWNILSPNFPYSDVDNDRLIKPESNHRYSIPLVYNQHPSHRKSQTGKTRLTMTAYTSFDEIQQIHTELRKTFNSRVTVPLEWRQHQILQLARMLKENHERFAEAILKDLNKPAFEVYLCEINPVMERAVLTAQQLSEWAKVENREEHIKKEHQKSWKPRVYREPKGVGLVIAPWNYPLILSLQPLLGAIAAGCCCVIKPSEVAAHYAGILAELVPKYLDQSAFRVVLGAVSETTKLLELKWDHIFYTGNSTVARIISAAAAKHLTPVTLELGGKSPVIIDPNFNSPNTCGVDSLSGLALAAKRVFFGKTNNAGQICVAPDYVLLPTKGNAKAKEELEEGFKQAFRSSFPSDQPGPLSDSSPSYSKIINSNHFSRLSSLLSQSRGRIVCGGKSDEKTCRIEPTVLFDVEEDDSLMQGENFGPVLPVLEVGTVEDAVEFVRSERRVGHPLVLYVFSDDDEFKKKVRENTTSGNIIFNDTFIQLDVNEIPFGGVGESGQGRQVLRYTYEEFSYQRSSVEIPKEIEPIFASRYPPYTRASFDLMCKPGLEIKIPETTPSSGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWS0</accession>
    <name>A0A8H5FWS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWS0"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5351567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="34802" checksum="90537FF5950B6C52" modified="2022-01-19" version="1">MILLESHNVIIQTTLGEKIAKPSSLDVSFVDYDGVRFHLSTPERKTLLLLSMHTRCWDQLVQYGALDVLKREYGSLLKPSSEPEYNVSLEIDLEQIPSGAEERDAFILSIALFKRNALAAPFELAFNTQKQLEASGSGQGELMEIHYRDEEAIYVQASADRVTAIFSTVFADETDRIYGKVFLQEFVDARRQPAIQNAPQVLYSNRDPPLEIRHLALRNSEDIGYVTFVLFPRHFSNPSVQHATISHIQLFRDYLHYHIKCSKAYMHSRMRHRVAEFQKVLNRAKQEVATGEKKTVTGRTMVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5D9</accession>
    <name>A0A8H5G5D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5D9"/>
    <dbReference type="OrthoDB" id="3245306at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1193" mass="127579" checksum="5551A9368EC33C0E" modified="2022-01-19" version="1">MSSSNATPSSKPKPSKMRTMARRTSSMLSFGRSSGSQHKNDSSSETSSVRRPSIDLDASTTNESNYASNASSASNASASASSSSLTVETALPDHLKEHMLPSTIPESPAREAAATAEEAQAQAAGRVRVPRTSLSQVVTAMNEASSTSSSAPQANDAPASTERQPEPEPEQKPTQTQTVPVPVPAPVIVTDPARYTTEPDSMSLKSTKSPTQGHPDDSGSVDKPTSSSMTNQSNARPQPQLQPHGPSDTDVEPESKSNSYFDTTPRPAVEIPTFHAQSHSSPEDLKKLNEEIYKNTIREIPPEGEGEDDGRGREEGVKTAETMTPRPYGSGSVKGSAPGPAAASGPAQAQGQAAPASAPQTRALAPASTTESGSKPAHSDRAVAVQPVPPVQPAQSVPPVQPARPVQPVQPVQPVRPAPPVEVAAEVTTKETQTETETKTSVTIPEPVVMPVPVSTNDVAKKDQNAGGNGTANANDNDNDDNEDPFADPVVPIQISAQPSFQPSFEQGRGQETNNNMPQPQPTLPQAPAAFSQAPPQVLYMPLPPFQDVSGGGGGGKFRGYDTYSDHDRANGETRSLLPHPHGQEQALQGQGYGYGPGFGYGATATAAAAPGSGMTQTHHQHQHSQYPNPNHPSVPSYAYTHGLNILPTSSTLTSSSDMPTNTVTFPRLSTPSSHKSTNASTTHPRLVRLGWTAYALPNPENTVYYVHSNWKITTDVDLSRLKELDEVMRYLDLNRVGESLTGEGGDDRDGDMGTGMGTGVGVPQGFELWLIDTGLDGLSPSTGQTQTQTQSTGNGTGAGAGKGKKRKRPAKGDFNPLRCWVDHRKCLASFDPIWDARVDGVSRSVSRRGERNSMGRTDDALDMEYRYWAFIESHPAHVALAPKAHSDAIELLEWASTDQFLAPYQSQLHGVRPPFTPTECQELLKWLKAFGNKPESSSVHTRVVARIFMRVLLWRQMHLRPHKPLPEDVPRPVYLTHIAQQTHYRSQSFLRTLLDVIVSIVFMGIPYMIYTRAVYAQRMDAEYGMGGLGASLRVFGMRDAGPLMLIGGCTCLVAAIVLSASVTFLTLPGLDWISRIVGFVAIILAGFSIVSTVLALFSFKAEMERTSLYVGGEGLMVHSRRIIMLSLPLAFCIYSIVAFAAGIALYSIRGMQAQVPPGLIESHFSNYTQWTTLGVLGGLGGVIAVATAVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G6D6</accession>
    <name>A0A8H5G6D6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_004815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G6D6"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5359070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="37997" checksum="6C517857D0AC80B8" modified="2022-01-19" version="1">MGLGEHSAAVGRRKLFIVGSVIIAILIGVGVGIGVGLTRNADSSTSGGTSSSDHNTPPVILCSRVHTRSSLFPNCNNSLGNVISDIQLISQLTTRIRLYGADCNQSALVLEAIKQTKTNVSVYLGIYNVPDDHTAYTRQRDLVRNALQTYGTEHVLGVTVGNEFMLNYLNANGGTEPNSAIGDQGAQILVADIADTRKMLSDIGVSLPVGNSDAGYYFNTKVLEASDYGMSNIHAWFANTTVQDAAAWTARYFEETNVRPAAQLANRPKMYIAEAGWPTHSSDEGNKNNGGSDASIANLQIFLDTFVCQANQNGTGYFYFEFSDEPWKDVMYGGVEGWWGLFPFQPDFKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8H0</accession>
    <name>A0A8H5G8H0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8H0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5360317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57619" checksum="4AF195B7BB0F7B9A" modified="2022-01-19" version="1">MFSTTVILAAPCAGLLLLELGTVCYNLFFHPLRNVPGPKMAAATNLYKIYYDLIIRGGLLSQIEKLHKRYGPVMRIAPNTLHFSDEKAYYQIYGASSTFTKDPELYSCFAMNGSSFTMTDPETHRHRTQIINPFFSRRAIIELEGVVQDKVDKFISRLINHPKDRAINMFWAFRCASVDVITSYVLGQDFQAMDAEYFEHPFPLGIQRQVHVLWVWKYFPFILPTVMAIPERIMDLISPLLGTLAASLNVRKQVIGHIDKYLADEKALEGVDHEIIWHHLIRKEKGGVGNAVQIPTRQSLLSEALILTQAGSDTVGNTCYLATFYVLNNPQVYATLKEELRKAWPDMDANIGMDVLEKLPYLNAVLKESLRLGHGVVTPLPRVVGPGSADILGVHVPAGTVVSMGVTFLHYDERVFLHPYEFKPERWLVPDTSEMEHYLRPFSNGPRMCLGQNLAWAELYLIMGHVFRKLDLKIHNTTIDDFKEFRELFVPSFEGRPFHAFVEKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDE5</accession>
    <name>A0A8H5GDE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDE5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="243"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="83957" checksum="13EC892A95B3F258" modified="2022-01-19" version="1">MRLLNTNTLRVQEFFTEIPRYAILSHTWEDEEITFQDIQNLATLADTCNGRQVTFNDIQAFFHPAQPKKGYTKVVQACFCARSSAFDWIWIDSCCINKESSAELSEAINSMYQYYEDAVVCYVYLFDVSAKYHPRNPESNFKRSKWFTRGWTLQELLAPEYIAFFDKDWTKIGTRWSLRDVISVVTTITIDVLEGRPIDKYSVAQKMSWAAHRRTTRPEDEAYCLMGIFGVSMPPIYGEGGEKAFMRLQQEIIRVSDDRSIFAWISDFYGEWGERGLLARSPLEFRYSGQVQASNTDAIIGNSPSSYSFNNNGLHIHLPLETHDSHSDVFLASLLCQTNDGSSVSVYLRRTTGGYYIRHHPFKAVLRPASPPLDDVRELTVRERPILRKSRASVHVTDKEVSQHLVILLPSARHFVCSQPPLDSEASISTGSLVEVETSHLQRTNFTFEYPSKSEAFTLSAVERVQRRWPFHTRLSYFLSIGDEEVDTIVDDYNDGFDTIKDYHLRADYMLGPLPNTGCFVSACLEMRGDEKKVVEVDYFSPEDSRSEGVTTTVRPDLGFWVPSTFGSYELEGRRRYMPHSQVVEYNTDNTTLVEVPDSDFLVLEYTAPQHFLRNELEAEQRDKRKGEEGPTTFYVAVGCHQSVAWTHITFEGESTDDVRANLDSIKDLLYDQTSATDASSHIKLKVWIGPATQLDSVFHKLRFEWVVDEDEEDEAVDAKRRGKTSWRVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHI5</accession>
    <name>A0A8H5GHI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHI5"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034617592" description="Aromatic compound dioxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26774" checksum="A91C6A82FF6F28A9" modified="2022-01-19" version="1">MRFAASVICAAVLTGIASASPLERRDCSAQIASYNLARRSARGIDVSKRSLYPTMPNQVCVLAPENQRQDWVQMNSSLVRTDITEGQPGILMLLDIGVLDITTCQPVTGAMVEVWHPNQVGDYGETFLRGAFQTGSNGIVEFKTIYPGQPADGANHVNLAVHTGSSMSSGVTHVGQAFFYDSWNHFVLMSEGYNTNSNPTVMNAVDPNYAAATSDGYNAIVDTLSIGDDWPSGIIGYITVGINPNHLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHW3</accession>
    <name>A0A8H5GHW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHW3"/>
    <dbReference type="OrthoDB" id="3010166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="19021" checksum="2CA39D6853297E5E" modified="2022-01-19" version="1">MSRKRCAKAAKKPHPEIRILPNEVLMEGMKLSPAKEHAILLFMQAVLPIGRTLLYQCIWLTSFTSVPKLHRILLSPGGNELATQVRCFGVVIHHRLDWQTYTDPNLLINVLGAMRHVDDLHLHIEREHFSILLMTDPGFTLLSLPNLFRFAVTPSEASKHRSTLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI40</accession>
    <name>A0A8H5GI40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI40"/>
    <dbReference type="OrthoDB" id="10421851at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748606" evidence="1">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="191" mass="20105" checksum="5CE34247F842C296" modified="2022-01-19" version="1">MLAIVTLVLAAFASATPVAPTCKPGFVSGSYNVLLSDNPSLGWQYSSSPAQVELVPLAITNLTEPAVTWAVWPPNGSSPDWTFSSAQFPLLDSCALAPSSDAQELTHPTALTTGKCIDPATGYGSNQSIFSIECDTCASDFSANHGCVLTMPEVDSLCPVAGFKNLVSLVHCGDSHTRPRTGYKWDIILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI43</accession>
    <name>A0A8H5GI43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI43"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="197"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="470" mass="49961" checksum="A3F0548A93F7DA27" modified="2022-01-19" version="1">MWAKEADTFGQYTDKKSFVSQISPSSSQQDIAQKTTMLLSPPNSLPTLPSSPSFHTPSFGSKASLPASALTVKEDGYPFPVSFDASSTDATKRRRLWPSLLIPLVLILIAASTRWVRHPALLDLVVGDRRLEESSLLGLHKRHPSPGSGEESLSVSFPTPSSSSSTSSASNPSSSSSSNQLVPTIPSSTSPPVLPTPFPQAWDQSSVPLNFSTQGCYSFFLNMTNSDSFRSCRSFGMLQAFSDSFVDAQTNLTLLNEVLWGTCNPPGPDGSNDEGAKDECTNSLRDMAEDMMDNCQKEWGERNEIVVQTRIALLAYPVFLSTSCLPLSNTNTYCYVSSIAQGATAASDIYLYSLPLGAGYPDSAKPSCGACERDLLGAYEGWLNSTGSSSGSSGASDPTFNPSDTSPSIGLKKTYADAVRVVEGVCGEGFVTNSTGTGSGGAVTSDNSSSAIHLGAKWIWLVVGVVGWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK40</accession>
    <name>A0A8H5GK40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK40"/>
    <dbReference type="OrthoDB" id="3252425at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="406" mass="45638" checksum="737CE06A8BA57224" modified="2022-01-19" version="1">MTPLCNVGDQKLHELMLAGRPQASFPNCQTVAKDLDTAFHAASGHIHTLLKEYPGQLSFTTDAWTSPNHYVFEVPESHTGKVMAQEFEQMLMCFGLAQRILSFTGENALSNDTQTDALDESTKNSFKKTIHVQCFNHTLNLAAKTLLGGFLESDDDVVGEEENKDEIEHVDDSIHNNLQIPDVDADDVNSLPSLQSFDLSDDESDIDSDHDDTSSIESVDEVGRLSPEVKEIFERESLKLKVAVKKIHGLSFAIIHSTTIGLPAWLRVCQKNELKPRLIPQDVKTRWNSTFESIVQLWTTSLEQRTCLTGITTQLSPTCDELAEYLLQPLETTKDPLGWWWPKQVVFPVLSQMALGYHSVPGFSIQKFLYFGSWSRKDLFNDKLVVDALVAEDEKRKGKEKLSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKC0</accession>
    <name>A0A8H5GKC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKC0"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="86" mass="9435" checksum="F883E70EE4E70AB4" modified="2022-01-19" version="1">MSNLINKIKESVTSNSSSQSEEPTFSIQPHPAKTNDPADLQPSSGLRNNDAMAAHHAHGPQIPNEQLPEPASRDELRARQAELNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKJ5</accession>
    <name>A0A8H5GKJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKJ5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="35238" checksum="05E60FF3367DD6A9" modified="2022-01-19" version="1">MFSCRLRGNLRQRLCTVPAISGCLGVLVEARGLNDLEFSYFYFSSVRIVFFPLNSRWTYLYCSTATLRQQVSGSRGGHMPWPSHFFDETACLASICKHSRHGGGVLGLLPPGRTTVNVIAKDMYLGSISDHISLESRSLFQTSSDLPSSDIPSTQPNSDVSLILALTFGCLLLILDLLLLIILIRIRTRMIKQRMQRRDAENLGSTLGTVTPAAPRMEEEFTTGYRRGGGFYYQGHGPRIQSDFVVDDVEHRQAPFPLSASPTDHEENLDSASVLSASEYSYRSSRIGSFDPKVAELWQNARSRIRSLIGSKSSSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL37</accession>
    <name>A0A8H5GL37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_003863</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL37"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="206"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5367021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="719" mass="79427" checksum="AE85E54430858368" modified="2022-01-19" version="1">MATASPSPYYVTPSPQPPSDLALFSEKTRTTPFWRRRRVVFIGVVSLIIVVLVVILPVYFEVIRPKHSSDSAASGGVRGSGGNGSGGNGGGPSSNPSSPSGAITGGDGSKIITENGTTFIYNNPFGGFWVQDPADPFNNNAQPNSWTSPLNTSWRWGVDTIYGVNLGGWLVTEPFITPALYQKYPGTARDEFTLSQAMRADTANGGIGQMEEHYKTFITEQDIAEIAGAGLNFLRIPIAFWAIETWEGEPYLERTSWTYFLKVLGWARKYGLRICLDLHAVPGSQNGYNHSGKLAGPNFLVGNMGIANAQRTLYYIRILVEFISQPEYRDLIPIFGIVNEPLVAAIGKDAITSFLLQAHTMIREITGFGQGNGPFIAIHNGFQPVSFWEDFLEGSDRIMMDQHPYFAFGGVNTDPITTDAEDGQPGGDWPSQACNTWMPATDRSRATFGVTIAGEFSSAPNDCGLFINGVPGGSSNPQCPEYVNYQNYDQAMKQGLRNFLAASADAFGDWFYWTWKIDPDIDGTIGAPTWSYKLGLENGWIEPDPRVYVGKCAELGIQRGNQFDGTYKPWQVGSETSTIAPESTVQFPWPPTAMNKIDVPVTLLPTYTSTGSVITLLRKPSRARRVVRRLVWMGGLILRIREVGLLQLLDVHILMSTLRPLTLCRLRLVLDLDIPTLDDASPMLVVTNDFWTRNLKLEDLHGYGYLCYFYYSHSYGQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL44</accession>
    <name>A0A8H5GL44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL44"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="37344" checksum="E004D0A0996DF8D0" modified="2022-01-19" version="1">MASSSQLSQPPGPSESSKPAAKLNRTNKFTIREIIEDELEKVSWIASKAFLDDRVGNFIWGFEKSPTTRSTPDGMKVYSFYAFVIKSCFYLGRVVVATVPSSSLPSSSSSPMAKRSTTPPPGSGSRASEEDGEKEEIIAAVACWLPPGKRINIWNLPMMIKCGVLKVSRRTGVGEFNVSERIVLQFMDQVDKTHKGAFRDRAKKSSASLDTGVGGSNTASTGSKASTSVKPVKSNDAWYLLMVMTVKEFEGQGCLSLLMREGYANAAKIAGSGGSVPPFILESSSSRSRDRYMHLGYEIEDQPPTIAGVGKVDSDGLRASKEARRNGKAPGVEYWCMVNWNPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLK1</accession>
    <name>A0A8H5GLK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLK1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035003058" description="Laccase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="165"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="377"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5367142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57413" checksum="5631DA1A27AD25D3" modified="2022-01-19" version="1">MLSLLTTTLLAVHATYAAVVNVDLDIVNAKVSPDGFERSAVTAGGSFPGTLITVNKGDSVDIATNNQLTDPTMRRSTSIHWHGFFQARSSYADGPSFVNQCPIPPGKTFHYAFDTAGQTGRQVVILSFYWYHSHLSTQYCDGLRGAFIVYDPDDPLKDLYDVDDESTIITLADWYHDPAPDAQDKFFQGGIVPVPDSGLINGKGRFVGGPAVPYAVITVEQNKRYRFRLVSLSCRPFHTFWIDGHNFTAIELDGVEHDPVVAQNVEVYAAQRVSVIVTANQTVGNYWIHAPPTGGSPTNNPNFDPTLTKAILRYVGAPNVEPTTTGTNNGHKLDDAEMHPIASEGPGKTGSQPPDVAFNLVISQPNLPFFDINGISYISPTVPVLLQILSGAAAPTDFLPSEQVLLIQPNQTIEVSIPGGGAHPFHLHGHNFDIVQTATQTSKNYVNPPRRDVVPILGGNTTFRFQSDNPGAWFLHCHIDWHLEAGLAVVFAESPAENINGPHKQITPDDWKDLCPEYDDLDPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLW3</accession>
    <name>A0A8H5GLW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLW3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="499" mass="56675" checksum="2340BF645DDC52D4" modified="2022-01-19" version="1">MLATLLSVLRATMRFGNPSFSLDRRAYYNYLRNLVLPAKLDPSRPPEDMERALQFLSELTSKMDPCHGSRTQQRLILVEFQENWSFVWSWLSGALKHWVQLDNEPTMEAGKRFQCKLICVFPKVVCPASIDGDSSEPILSFMRKHPELFETIVHVSTYAMDRSDHHLRWMLSSIDLALAAAQMNDCRLASRNADILIHSHNTINLLFSHISTAIRKPPCADSYPDLQLRYALRVVRLLAHYRDETLSVLIRSYDLMTYLSLWCRTLVAPWRIEKLGSNTDLIEQQVESLKYVLFPFDDAVKDHEDTAMVLALRGGILQSMIHARSLIDYEKARPETPSLGRTLAQIFDDILQNLPAGCLASARVLSVCNKAVARVKDSDDENLRQALNTFLQNGDRTLRRIWEQSEFFVVRLGGLREEFEGQGLVACANPEVSSNPRPCTSQLILCFGCTFGSLAVSFSGKYHIHTNTQEPMCKMQNNRVLFKDVSKATLEGPRASNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNY8</accession>
    <name>A0A8H5GNY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNY8"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="247" mass="26927" checksum="D432F03FA940E4C5" modified="2022-01-19" version="1">MLQAQQPPSLPLSNNDLDTLKGWIFSIAIEWLIHGVNVTLALTIFCAILSQQKYPSGPQLVLLALVVFMLLLATTNATLTVLFSLLQSPLYGYNVDNVANVIQQVTDTSIASNIVARLNYVIGDGIVVWRAWIMFPQNLVVKGILIICFMGSLGGACADGGLATVARLHNLADVGQKKGVLVMTIPLLITNMAATGLIGYKAWYTFDGFVWLLPHDYSKASWSGYQKDFEELWQSGFEGTKDSDAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR92</accession>
    <name>A0A8H5GR92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR92"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12297">
        <property type="entry name" value="RRM2_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034398">
        <property type="entry name" value="Prp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="593"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="667"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="758"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="858"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="549"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="927"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="978"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112831" checksum="02EF23BEA2A93B7E" modified="2022-01-19" version="1">MDEEQSLEALANILNDLTEKPFDVSLHAKHVRLTKSFEGMEAEKVSALEMFTNYFAAGEEVWLDLLDAKERSVDLNTVDGAQEVLALYERAEQDYLSIPILKRHLEFVLGRHALYANGELKPDELEELFSTDWTRLIINDIMKQAVGHLSQSCVLWDRMRDWELENLESAKEPEKFTLVEHVQALLLDRLGTPHSNSDDTLQAYSSFTTQYKSPAEYEDLLVAASTKKSKVAKAFDRRNARETAVSMKEPLLRQRKKRFNDEPGAEEALRSFWTGYCDALRLNNVGKEAELKVFQRAIRSVPACGEVWARYIRCVERYTDPEHASEGQETVSNLFNQAFGNPILLADVEHIIVLVLARAGFEKRLIDTGMSDDDTLPTLIGVLESGIDATRKASKEGDPRLRLEKYLSEIYRIAEVNSAVVGVWQSATKHYKNSYLVWTHYTDALIKFDQLEEARKVFTDICQRKLDWSEAVWEAWLSFEHLHGQVEQVDDCLDQIEKARSIVNARRAKEAQESYQAMAAYTAQQQTETQSAAAAAAAALVQEVQMDVDSVETSGGRGTKRHVEEPGAEEHEGQKKPKLEAKSEPLKRDRENCTVFVADLPANTTEQDLKDLFKDCGIVREVKVTQLAGTVVATVEFNDRDAVPAALTKDKKRVHGEEIAVHLAWQSTLYITNFPESADDVYIRDLFGKYGIIFDVRWPSKKFKTTRRFCYLQYTSPSAAQQALELHGHELEPERAINVFISNPERKKERTDQDANSRELYIAGLSKFTTKADLENLFKTYGSVKDVRMGLDKDGKCKGFAFVEFEDENIAQRALAANNHELRNRHISVTVSDPRIKSKSRNLNPDTGFGRKAEVKNRSVRVKNLPPGTQEGLLQQAMEKLAAIKRVEIFADKNEAIIELENAAEAGKLLLRAEPVVFNGATLQLSEESQAKPSGGPESSGLFVPRTTAGRPKAGIGHKRKVVQPIHNGPSGSKAAESLTSGSGASPSGTTSSGKGQDDFRKMLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRB5</accession>
    <name>A0A8H5GRB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_001138</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRB5"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="16">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5369843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="60643" checksum="3F330D3B20A51685" modified="2022-01-19" version="1">MPQLVTYTLFVSELAYPILPVMDPRKARDPRLVRADPRLQRLQQEPSTSTPTPPPDSQASFRDYSQNDFQHATGSVSNEDAVGAVNGPPPAYKPRPLFCVVCASNQNRSMEGHHALSKAGFRVISSGTGSAVRLPGPSIDKPNIYSFGTPYNTIYEELNAKDPRLYTANGLLQMLDRNRRLKLAPERWQETRTAADVVITCEERCFDIVCDDLLTRGGEFNRPVHIINVEIKDNHEEALIAGKAILDLASAIEAAKDIDEEIDSILEAQQEKHPHNLLHIVVQTAEHTGLSRSLIIEIYTETFSSYSLTVFSPSGKLVQIEHALAAVSQGTTSLGIKASNGIVIATEKKSPSILVDDSMLEKVAVVCPNIGIVYSGMGPDFRVLITRARKSAQAYWKMYGEYPPTRVLTQEVANVMQQATQSGGVRPYGVSLLIAGWDNHRGPTLYQVDPSGSFWAWKASAIGKNMVNAKTFLEKRYNDDISLEDAIHTALLTLKEGFEGQMTEKTIEIGIVSVPTPAELEESHTGAATGRPKPTFRKLTEEEIRDYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS39</accession>
    <name>A0A8H5GS39_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS39"/>
    <dbReference type="OrthoDB" id="3229881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034477681" evidence="1">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="21415" checksum="B50B5D5983903801" modified="2022-01-19" version="1">MFPLVLLFLCSLSLVASIPTWMYAPGQSQIGSLVPGAAYIEALGVGYQPERASAMQRHLASEEQGHLGNVTVIFSRRKRSADLFYINRQQLWQFANETAIFPVNLVNTTTVIPDTGEVPLRLVTGNKDKNLISSGTWRWRGTMLLYDLGPLTNGGVYYDCPQPTGGSTVITFLKPVPTPDGCNLVTLHAWSQLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS73</accession>
    <name>A0A8H5GS73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3259294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="207"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1672"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1676"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1966" mass="224625" checksum="3C83367583E3DD1E" modified="2022-01-19" version="1">MISHVIAFDSPVMKVYDVLPPPPEDLDEVLAIMFTGPCKPTEKDYKRTPMLVRRKQVFEALTWLRLNHPAYEDVKISMDNLNKYPEDTPPVTVAFKEMQSEGNRIPEATSIHDNELEIRTELGSVPFVVHGITGEQLQNTSVELQKAKALAYLKSQGKFLAVGHSEKSSTMFNNPLLYPSIFPWLFPYGMGSIGMTTLKSFSEKSHKKYFMNYHDQRFQSDPLFSFVAFSHEQVKKTTSNGFALTQKESFSAIADRILNLNPHVLNTLIDKLSKGGIVRPETEEEKLCYEVIQDLDHVGGTVKGSMSSKKFLRTELWSLISYLGAPSWYITFAPSDLTHPLCLYYAISDETFDLNLNLPNDERTRKIINNPVAGAKFFDFMVQMFIKHILGVDTDHDGVFGKTSGYFGTIEQQGRLTLHLHMLLWIANSLSPQQIRDAILKNENDFQRRIVEYLGSVHCGDFMTGTQEEVEQNLQTASGNEDYVNPLYSLPQCPPIECLCTSTENCEPCQAWTAKYQQEVDDILSRTHIHKCKSTLTKQGTRKVGKDYLGCLDNKFGTCKARFPRETFPTTQVDTETGALRMKKTEAWINTYNQTVTYLLRCNSDVSSLLSGTAIKAVVLYVTEYITKWNLNTHVIFEVIRTILQRNAEMLTGTLPRHEKARKIITQIVNLLTVKMELGAPMIALYLLDKPDHYTSHEFKSFYWKDFVSEARRFWQEPDQLQVENKNHEKVVVIQHNGKLVGFSSVFDYIYRPEALSEMTLYEWVCQCERVKLAANKRDVNDPDDEISERYDSSSEDSSFSDEEDTYRPQNTLKKSLANKPLTKNVLPKKGHPFVHEHPLASTHYLRIHDKRNIVPNFIGPSLPRRNKGDREYYCSVMLTFFKPWRTGKDLKEKKETWDSAFLDYQFSAQQKFLMDNFELRFECLDSRDDYHAQRKAQSLGIDPSKLEPDFDDGIHFDPFKCSDDSLGVRERRRQLDMQEMTDLLANTGWTNAKCDLKSHIPASFDYPSMSPAAWRLEIAKMKSNVITNKLKENKDQQYNFPNKYPDQVEVLDQHMLEEKLRSNQTQKLIDDLCLEFSLNLEQERAFRIVANHAVSSISDQLKMYIGGMAGTGKSQVLKTLREFFKRRLQSQRMIVVAPTGTAAALLQGSTYHSVFGINSSEEGEFWKMSASQICSRLSGVDYVFLDEVSMLSCKDMYKISAKIASALNRPLLPFGGMNMIFAGDFAQLPPAMGGENVSLYSHTIGTSSSDQHASIGKYLWHQINTVVLLRKNCRQTGSSIRDVKFRQALENMRYKQCTAEDITLLRSLISDPSNESRSIDNPRFRNTSIILTYNKHKDIANELGTKRFAAETGQMLAHFFSEDEEVVFDELPSKTHDRKRKRRKATKHKINDEVQQQLWKQSPSTNNMQIPATLSLCKGLPVMIRFNGATELCITKGQEGTVHGWQAGKGRHGQLVLKVLYVKLEKPSTDVQFKDLPLNVVPITPNTRRINCKLPDDRIIQISRTQVEVLPNFAMTDFASQGKTRDPNVVDIYNSRDFRAIYTALSRSSSADGTIILQGFNVNHITGGVKDKGGYRQELRELEILNDITKLRENRKLPPSIIGDLRGSLIQQYRSHFGKSHTPDELHESLVWDTNEKFESTLHKDISWKILEKENTPPVKKKTLGNFVPIEHPSLHSSPTPSEETIHPTSHNSDRLIVTCDYPTLKWSANSCAYDSALMLLYHLFRTERAAFLAESDNFSSILMNELSATFQSNSSNYADIRDQIRRELSILDPDAFPAGAYADTSDVLHELMRSVSPTTKRTVVCYNSHFSLQERTQHNLLLTRSTGSYQSTQDCVSHFVEPWADQCPSCHSDMLRKYTFQRFPKFFLMSIPYECDMEIQNIIHVPQGAESRQYHINGIIYFGNDHFITRMFDGANEWVYDGIGTGIPTKLSPDFQAHSNALEFFAHKKAVVVLYVCSENENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSD9</accession>
    <name>A0A8H5GSD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSD9"/>
    <dbReference type="OrthoDB" id="2692698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="53481" checksum="05C7412A1D5F71B7" modified="2022-01-19" version="1">MNTFSSLKRTANIRSRKHGIFTKKSEPLQIIVEEEEEPHPSCSSSKQRKQFAVSPSDIRIAKTPLEDAFDCDTLLSEPPRPAPRPPSTSPTSSASSSPAGSPDSFRLTFTDASFKFPHPPIPTPSSSSWSPMPSPRSPRSPSSSPISSPSSQGTPLTPSSSDDECDAAFRLAPAPTGFGLKRLRSIKPLVIVKHGRSQSAPAPSGPLPSLPTENAELEADIEFFRAPKMFAASPLPSSTGSSHSESDEEEEVSDSEWYSRDISRLLTLRSVLPPAFPKRISASAPAPASSTLTAPTPTLRPESLCACIHVPPSPTKAGGYPSAQLDPDFPKRRSYLYPIPTRPPPPVPSSPVSPVTPSSVPATPITPATPVLASSTSTGSSRRRTHPPPRMSIPHFDHVHQLMWLFQLGFVRFEFGKRGFEEEADSGGDVFEGVELKNTKSCFSSSFGFFGLLHSFSLVFLTHARLLNTFSCYLSLSLAGFRISYWSNVTTKSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSV3</accession>
    <name>A0A8H5GSV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal targeting signal 1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSV3"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034446982" description="Peroxisomal targeting signal 1 receptor" evidence="9">
        <location>
            <begin position="21"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="82787" checksum="35FA0D10663D236B" modified="2022-01-19" version="1">MKSILLYVVAVYCLVHVVNHVKVFGALALPGCGFRLFENTCSSTVPMSLPMLVGGSDCGPSNPLQNLSKRFDNDRGLQQDYYAPNRAGSSKQTFRSQQAPTVQDQDVANFFTSKSPEFHPATNPYEFSDFRKALPSVEVQQRGPPTAGWAADFLLQQGPHSTPLQSADTKLIASTEHISSAVQAHPSVVQTPSSAGWNTHVPRWGVQPMPNFAPQTFLQTQRQTIPSQLDSKAWEKVFEDQELVSTSELVLQEAILESQARQTPEDADELARTAGLLLETVREETNPKFQNSQFMSLMTQLRDRKVVVRGNEMVENDGSVAEGHVDVKGKGRAIDAPFSQAGLRFDSEPLHNLGGPLAFQPSSQSGQTGLQDDNDRYFEQENAEFAGFWNQVHSQTGVSEHGMHSSWDKLQQEWDQFETTAEGIKPLNLYQFQRNNPFLLGSSSRTRNHSLHDQGRFDSVLELEAEVQRDVTNANAWFELGVKQQEAEREHKALQALQRAVELDPTHLSAWLALAVSYTNDGQRLGTYEAVREWVMGNDKYKAAVGDYLAKYPTREGLSNAGKFNHLAQCLLHIVQHSGLDDLDADVQIALAVLFNANEEYDKAQDCFRAALSIRPDDWLLYNRVGATMANSGHANDAIDYYYRALELNPMYIRARYNLGISCINLRRYEEAAQHIYDALLLQDADVVRDPGGVNEARGITSSVLWESLKTSCFHMQRLDLATLCDRQDLEAFRVNFHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTI4</accession>
    <name>A0A8H5GTI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTI4"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033990059" description="Carboxymuconolactone decarboxylase-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="24543" checksum="B9C17E6D8E4DA485" modified="2022-01-19" version="1">MARLLSFFAIFAGLIYISLGTTIPSPQAVKRDDNLPARVPYVFPEPGTDPIADHIRQRRTNGTLLDLDGVLLNAPLFAQAWDGLFGVIRDNSTLPPTMRELFILRVAVLNNASYEWLQHEPVGRAAGLTTEQLLVIRLAAPFLPDMNVTSIMGPDLTAALLFTDWMTKSVHVPDEVFNGLRQFLNDSQVVEAVGTAGGYNLVSRFVVSLNVDDKMDVEVPIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTP0</accession>
    <name>A0A8H5GTP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTP0"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5370799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="732" mass="80926" checksum="DBDE32980B2D6B57" modified="2022-01-19" version="1">MNADEETFAVDDFEPSVDDAASKKRLGSGLTLVLPSLKSLKANKATKKTKSKSSAYSEHSFLEKKIPRPVKLKPLKEVLSKLLAQIKKKDDYAFFLHPVDVSQVSGYTDVVKHPMDFGTMTNKVNRGRYRSLEEFANDFRLVISNAKTFNPPGTIYYTEAERIDAWGSDHIAKAASTVIQYETDWNIEVDGDDNDPVNIEDDVEMSVPSPMDLDVPAPSAQSSAGPSRRSTRAPYKKPENANSSKLSESIDSEGRLPGSKDGLGAFPPGSDWAKTMLDLKLKGKKYKTKKERLRVEKEGPPLCADGSIDYYNMEDPFSILSTLVPDTLSRPKLTPLYPPSSQPLSQRQASYDPSASQTPQPPPSSSFPSPVNVSSSRPLFSPSSTNSKSRHWTVVRNASSRGKLKDREEDDPGDVPEWKLPREAHATDFGSLAFLAGELAEEMKRRSVSGDDEENCFNVIRDSLDCEVKAKQLQYKNQEGVVDPGTSYWNTARAAEAEDYLRDVVYGGVGGLAYARSIAEFVAPSQDSGSTSDLFLARWVQENVLDSLTDGRHSFLRETAFLLAQRARTGSSQLSGDAALQLRKSLELFPSVTQALQTLLQIRAHKIDMAALIRAPQELFQSEEVWAWKEIKAKQLADKPTGDGQPVSYEVESSDDLNHVLAYVANAISEYTQKSTMASVKEEDTETSSEDPILRKIRLNLLALTKRAPIDTIAGIPKELVPEHIRDRVPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTP2</accession>
    <name>A0A8H5GTP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTP2"/>
    <dbReference type="OrthoDB" id="2504001at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="389"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="758" mass="82934" checksum="5FB87595F7D81FC1" modified="2022-01-19" version="1">MWTNMQGSTRNANSVVLYLSASQPVPPVPFELQSQFPPAVWSMRLTALTNASKAFAKPLFERAWALMGLLSMIIVPAVVYNAIYSHFHVRDENGRLITDRLVEARLISMGLFIGVVLLFIIPIGIWKFIGYLKLKRMTDQWVKSDRMNFGQNAVSWRVKTPSIFRDRLILIIGLPANQAPSNFNPNAYLPSYIGQPTDGNDSYYYPYKPEPGLPRMSVVGNVPLYFDEKKGFEDVKVVVISAVSSSGPRDLSELGVLDSPKDMKKVIAAQEVTGSSLAVAAFSLKLSSLHVPSVSASPSLVKRADNTTEVPTVYLNYTTVQASTYNESVGFAVYSNIRFAQPPVGDLRWAAPQPPLNDSTVRNGTWSTNGTRLHGGRGLLIPRCLGPNQGQQDKKLPVFVFVYGGGYSGGSKGGNTPEGLFARSDNGILFIAANYRLGFLGFANGATIQKNGVDNAGFHDVRATLEWIQEYIEEFGGDPNQVTVGGQIYYQIAAYGGEKDLPFQRAIAMSGAGVLNAGHAWPEYFENLSSIIGCASQTSTAPTRKFSATSTHAPSAVGFTLQPMSDGDFAPNLCNYGFNIGKFNKNVQLMIEHESNTRNYATVTTEQDFRQQLRAIFPSMRESVIASIEQEYDITSKALPPAKALNGETYNYVSHLGSATHGSDQSYAFYGQDTSASMDGDGGSEEINEEIAITFQQYLVSFIITGDPNAKFSNFTNWPKYGSEGNVLAINDTSGLSIVSDELDTEAVRFWNTDTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUR7</accession>
    <name>A0A8H5GUR7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUR7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="16246" checksum="0C308193B4296074" modified="2022-01-19" version="1">MVLLPRVLQQIHSFALLNNPRNLDARVSCSKTILFGDLCYKIAANNGLTLAQLQSYNPGINCNKLHLGSVLNLCPSTATSTASGSTSTATGTTSMCPKTYKVKALPPPMSLLQVLPPPGRLRPSLAPLTAPQAQRRLAPLLPVPTPSLPPPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX54</accession>
    <name>A0A8H5GX54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper radical oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX54"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="3">
        <location>
            <begin position="292"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47848" checksum="2CB6BAB34D123695" modified="2022-01-19" version="1">MRSNHETTRIVDNSTIINPTYEFYPPKNIHGQNGTPIYSPFLHNTLNANHFPLVITLPDGNLFIAANTQAMIFDWKTNEEVRSLPGIPNGVRISSPLSAGATLLPLTPENNYTPEVLICGGSTLDDSTALFTAGRLSSQSPASDQCIRMVLNDEGIAAGWQVEHMPEPRIMPELILLPDGRVTIVNGAQTGIAAYGFCIHIQTKDQIGECDSDHPALTPTLYDPTAPLGERFTQEGLPTSEIPRMYHSTSSLTPNGTILLAGSNPNVDVETHLYPTEYRLEWLSPPYMEKPRPTYTSLPKTFDYNSKITLDVDLPPGAENVSVIIMDFGFATHGVHMDQRLVGLVSELSDDRTKLTVTGPPSATIYSPGPAFVFVLADGVPSFGSKTLIGTGAQPPLDEDALANVLSSPPLYWDKWTGAHPGAPDESNFFTTVIPAPSATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYF1</accession>
    <name>A0A8H5GYF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYF1"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5373576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28030" checksum="557ED5408F3885FA" modified="2022-01-19" version="1">MASTGARENVFATRMALTNTKLRLKGAQTGHSLLAKKRDALTTRFRSILKKVDEAKRKMGRVMQLASLSMAEVTYAIGDISYLVQEQAKSATFKVKSKQENVSGVVLPAFEVDRVPGSDFNLTGLGRGGQQVLKAKEVYAKAIETLVELASLQTAFTILDEVIRATNRRVNAIEHIVIPRLENTIKYIMSELDEMDREEFFRLKKVQGKKKRDNAVEKPKTPEEPDQPTAFDEETQGPGDLLSNKDVDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ76</accession>
    <name>A0A8H5GZ76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ76"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="795" mass="85394" checksum="AB7549D6573A27F2" modified="2022-01-19" version="1">MDEPFSLKSYSSPLVASQTDVYVTVAGDGVHVLDVGELHTILSLNRKATLAKTSVVGSVFTTFAARQNTLVVWTEDVSASIAERAKQKVQEITVDHSIDFLHPSVLQSKHGHLTRLDQTLSVHYPADILASFYFDDCLVSFTTTSVQVVHPESLSLLHDIPIPTPKNILSCTCSQSGFISILLTDGTWSSYQLAPPSLIPLETLTLSSTLSSPSLLSLGSSYVLLASVSNNQVVLLLWDLAFSVLLSSRTIPLPSPSIHPHLVSYDRGNVLLVLSDKKKKSTSLLIIPTSLPLTSSLAYAMSQSKPTEPWLASSSSSHTDLTNSEKNLLASINAKAFFDHVQANSLGYNFTQTLLWTLFGLDVYTPESSKIIQYLITHGLVSSSMVSKYGGLLGVLRVKGDWPTILHILRHSSVPDLTEQQVISALAVVLGNHLRSSASNANDEVMQIDTDVGNGNANTNGDGDGDIPSLVLFLSIILSPSPCSSSSSSPSPTPTPRWLHSQSSLRLALRTALISSLTSSSSSASSTSNSASALPTSSIPTTTTTPTSTLDPLTILFPLFQILIGWVRVHTKISNTALKLPSKKMKKVGKKTKTKEMKKMKTKGQNPGKGLAEDVDDEEVEVEAEAEEPGPQPGEGTPTHVPIPPLQPTLLFLTSLLDVAYPFLSTSTSSSSSSSLTTLLTTLSQTYIPTLLEIIEQGEPLRGALEGFARVASDSVAGEGGEGGVDDNDNDDDNEGVGSIAGKHNKKNDKMKGKGQMKMKGKGKGKDLDWRQRRKMLHEMEGMAVGLYRLEEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ93</accession>
    <name>A0A8H5GZ93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ93"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="263" mass="29244" checksum="1EC761F002DF0123" modified="2022-01-19" version="1">MSRTSYDRYLTVFSPEGRLYQVEYAFKAISGSGHTAVAVRGKDTSVVITQRKVPDKLLDASTVTHLFSITPTIGCVMTGLIADARQQIVRARSEAADHRYKYGYEITPDQLARRLANINQVYTQRAGMRPFGITMILIGIDPEHGPQCFKLDPAGYFVGFHATAAGQKQQEAMNHLEKKWKKLDNGRGADDPVQAGKNLGRADVIEMAIEAMSTVHGTDYKPSEIEIGIVSTAPEEDVKTKGLWRTMDEAEIERYLLAYAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1L6</accession>
    <name>A0A8H5H1L6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plant basic secretory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1L6"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35388" checksum="4EA7F084D6F18D2E" modified="2022-01-19" version="1">MPPLPEPGFPELSLTIKDLDHSAVELLYRLVGNPKNILKEGIVECLRGLYGQRYPAPNIIKVSVTFRSFPGVAYTSGSPHNPFSSKEIHFSLDHINNTFNNFKGSKEEKEKRTRDEIRGVLTHELVHGFQWDGKGSCPGGLIEGIADFIRLKASLAPPHWNRSTARPSDPSKGKWDAGYEKTAYFLDWIDRKYSRASTTNAPPPPYSTRPEPSKPTPSLLPGQSGIDQTCHPEQGQSQSHFRPGYTPVYIAPLQMPLPVAVPPQIAGGPENVNIVQKLNAWLRDREYDQKRIWVDVTGKKVNELWTEYCNDKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLM1</accession>
    <name>A0A8H5LLM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLM1"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="65406" checksum="6A5D3E3F9530B2CE" modified="2022-01-19" version="1">MIVDSKSSSFGELLTTNICPTDAQVDAVRSALARPLECLSSLDSKIQSLESTLAELRAEKLSLQSYIDAHNSILSPTRRLPPEIVAAIFTYTLPHDHFPTRSSKASPLLLGRVCSQWRAVSLSTPELWNRMHIVIPSSADSGLLCQVLTKRVEYVATWLSRAGALPISFSLYSYNWTQHAPFQEDRVIMSNILRSLMSSLFGLSKRWQRVEFKVPGILWKILREYVTKLTAADVPMLESLKVDFNTWGIADMTESELFHNMVESTPLRSVSFTGLCSKVSGMSLDWKHLQHLQLTSKFNDRFMNIPEVQNVLSQCHELRSCDIGVLVSATPSPPSLDLPSVIALPHLRDLQLSLTCPNAPLSNLLPSFFQSLSLPVLSSLSVSFEGKYSPVNRLPFFPLLAPGHNVEKLMLHSSVLPLDPLIEVLEACPDLKTLKIEQPPPSFRGRAEGTLGEGLVMRLIGAGVHEMSHASENGNGAAGPALDPLCPSLEVIHLSNLDAKDELLLQFARSRTRASKGLTQPQPNLHPNSIPNPVPKTTPLKVFHVRLPRYRQWFDIYARAEELKNQTGLDIQLVHSTEGADGAGDGQETTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMS5</accession>
    <name>A0A8H5LMS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMS5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="69135" checksum="C013233454238465" modified="2022-01-19" version="1">MSKDSLHCPSPNLHLPGWWKLIMIGKQGPCLMGTKDPLCQIQNKYKDDYHLFVPQMSEYGRSTKQKIVDYARAVTDDLPPLSFLLPTSNFTFLTHHSSLHCCGRPRLYLSVKIHDIHDYTMNTKFLTPPIAYELLRHPPPQNIDISTPSDEVNQAFSCLNCLATSSRTTDVADYDRNWPNIWAWTSALIKSFIFAKEPPQTVRGLLFRDGLIVLIPSLFGYPKLLRRGPLCPDIVWSRVRRRVDIFPTLIRVWMFAFDFCEPDSHFVIWPLLLSNMNSRTTDLHDSDRYRHCQLFARTPGALYRVFSYITTAVRCANHYPPTGVVSEFSRPALGLVYVLVATGCKDVLELVLSHGLLDLFGLFKMRILRPRKIETNTMTSRERLWLEVGECEERLDILYFILSMVDAAMLDDTYKGPACAHVLRMGLLMFIIRATSVVLTAKLSPERHLCHQERLFGLFSAILGQLQTTFWNKCIMKLFWCSMKRIQDVHPKPLVAFLDLRSSLQVSTHCRNLVNVWMETLRIGDQMAKRWISFENQGVVICANPESIYSSARVKECALTKGFTEDNVHDAKQCIVLNSVKSKTGRYIIIGRNVINSTTVAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LN24</accession>
    <name>A0A8H5LN24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LN24"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="106" mass="11501" checksum="19916B7BDB7E1ADF" modified="2022-01-19" version="1">MQPARSRVNINGSSSFPSREPHNYRLSSPGGQNDEKKCGDFRVYQALLRPTSDPIMIVRAYAATGACVHQVIIVTYVDSVRIKTEGSPPKELAVICAVDVVGVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPH7</accession>
    <name>A0A8H5LPH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPH7"/>
    <dbReference type="OrthoDB" id="3265169at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="380"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="63176" checksum="CEBA2CC1991EE703" modified="2022-01-19" version="1">MSAAAAFAGWSNQDSGGHGDLFAAFPGARSGVGQSPFVGLSSPAAFSPFAPRSPGNLFAQHQEYALHNRGAGDWGDGQRFVGWEGPTPGIGPSFFGGANGHGESHQGFSANNGHFGTAGVAEANGNVGGWFGKEGQKKMQHLGYKSTRGSRRHDRGFFDDDDDEEWDEDLKDWERLHHTHGFHDETDWDLLDDLDMLGHGDRRRHRRSGSRSGSRQRRHSFSQIYDHPHTSPYSPSDIPPPSPFYQLSTLSSASFKSPRRSLLNLPLLGTHNDDPFRPRPLSWRADYSARPGLLSKVPLPSLLKSPASSPYGLDGFHDPVKRVLHPYLAFSTSLTNFSLSMDLRMNPRHRVQSRDARRLNGLLVSALGGFAPPIHFLHLPHSSELTKIQLNQPACTPPVDRMRLYHPRLPWYVDVVQIRPGFGGVTVGDVILQLWMSLQTQVTQEEYGAEEMDEHLDSGAERRLKKASLAYGMYSPGFGVGAGIASKRYGVGRSFISRAWSERCLLVGLLEGDEVLTGQERAAGHYGRKEKAEMAEGVRRVDWLGAEGMATWIGLRRSKNGIWEIKTQTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPI1</accession>
    <name>A0A8H5LPI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPI1"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034194360" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="43844" checksum="4C7FAB2A786A020F" modified="2022-01-19" version="1">MVFLSSILSTALTAVSLAQLSSAHSHPTPGSPEAIKRAVFQQNARRSLADCQDALSKRGGIHEQAKARRENLANEIRKARGLNTAAPFKRDLDSVLATDHLSNKTGITNNTDASTIFDGESSCVLASEVTQGPYYVDGEYVRYDLREDQKGVDIYVDVQLIDVSTCEPVPDVYIDFWHANATGVYSGVSASGNGNSDDEANLNNTFCRGIQKTDEEGVAQWLSIFPGHYTGRTPHIHVLAHQTNGTDFPNGTYIGDSISHIGQVFFDQDLISEVEAVEPYSTNSQTLTTNDEDGILSQEADSIDPVLNYVLLGDSVSDGLMTWSSVGIDASAVYTTSAAATLTENGGVANENSMGGPGGPGGSGGSPNTTTSSESESESNASAEISIIGFQWRLYVFASFVYAFASFLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPZ4</accession>
    <name>A0A8H5LPZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPZ4"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12063" checksum="3703C00F326149C5" modified="2022-01-19" version="1">MIGLKSTLNVIDNSGALIVECVNILKNKVNNGWGSVGDEIVRKGDVRRAVIVRTKKPVRRPDGRFIRFDDNAAVLLNNKREMLGTRIGGVVSADLKLKGWGKIASVAPKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQS7</accession>
    <name>A0A8H5LQS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQS7"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="93" mass="10353" checksum="F60CC24FBE402E9A" modified="2022-01-19" version="1">MLLADSGLKILTWAGDADIERVSNWLGHHAAALAMDWYGMERLAQTPFTKMTMVVDSKEKAPAYQSEVALEIFRQILDNEQLHSVSDCCGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQU1</accession>
    <name>A0A8H5LQU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQU1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5366021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="328" mass="36601" checksum="2AFABAD57DAD48ED" modified="2022-01-19" version="1">MSFEKTCTLNTGATLRQIGLGTWLSKPKEVENAVEIAVRNGYRHLDLAMIYQNQDEVGAALKKVIPSVVKREDLFLTSKCWNSSHQPDLVGKELDETLKQLGVEYLDLYLVHWPVAFAPGRGFHPLHPTLQDEVELDDKTSLVDTWKAMIALPKSKARFFVRAIGVSNFTIEHLEGIIKATGVVPAANQIEAHPLLPQSDLVAYCREKGIHITAYSPLGNNLIGKPKLTDDPTVIDIAKKLNATPAQVLIAWGAYRGYSVIPKSVQEERIISNFKQIELSEEDYKAVTALAKDGHTRYNIPVAFKPKWNINLFNEEVEKTAAHNVNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU79</accession>
    <name>A0A8H5LU79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU79"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="43271" checksum="12E3F51A2E5C9863" modified="2022-01-19" version="1">MATKAYTIYSHYDPEDREALERETGQIQDSVDEADRWEAEARTVYKRRITAPHFVPASYSDWSSLGASSSKQTPSSTPRSEDDVADWYRSLTSRTSTPVDSAKPRTPSLTSKAKLSSEVQQSKKLDKNNWFIQNVQSTNIRPSNASSSSTLADILARDPPPLPSEEQFRPPVFLAIGPANKGFAMLEKSGWNEGEALGRNVIRRSRRLDLLEDIESDDERKRKRKRTVKQEEVEVATEDADVKELRQVSVIDLTLSDSDDESCGEEDVKEETVDEKDTEATVSEVAGSSTIDQEASESGRKALIVPISTVLKNDRLGLGLKAKTEGPYKSSVKRITHNVAALANHLLNAEEARERKSKFGRGRRGLAREYKQEQLKRQEMMAYMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUG3</accession>
    <name>A0A8H5LUG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUG3"/>
    <dbReference type="OrthoDB" id="2993597at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034334316" evidence="3">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="37995" checksum="BFC8D499E3AECF80" modified="2022-01-19" version="1">MSHLRSWIFALSVSIVYHRVVALEPDYHPPLRREDKMSSVLRLFSRTLNARTSTDHSVNVGAIVGGVIGGLALVALLGIGYFFYRRRKLKHIEEGKVEALNFRPSWMVRVKSFRKSTAPTSFDQRTLHEQKPTMPWFARLSSFWSARPGSPTEDSLIIDKKSASSAGSDDELFVNEKAPALPHKRVVELQRQNPPPINPIIIIGNRPVPPVPLQSADITDRNFVLAFPESKGQFPRDSLVSYDTSNRHNRRRVQIPPQAVLIGAPQTLTSKRRSRSLMGPRTISGGVGRARRSLLSTMPRPKPQQQIPSSVQTPTETEFQHGRQAIRVDALNRLLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVB8</accession>
    <name>A0A8H5LVB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVB8"/>
    <dbReference type="OrthoDB" id="3215534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="670" mass="73300" checksum="7963F4CE652E1315" modified="2022-01-19" version="1">MSDSEDESTKIPFGGHGGSTKPRQKRSFTPTSDDGEIVVPAQDDSDSPAPPEKPPEKPPEQPLIRQSLAFSSEFSSNSSHEINTYQSSATAPSGSKKKAFLPGQRVELTTKPKKNKPKRERPKASYAGNTGRFRLKDYVPTTVEHAPAPPSGSTSTLNAFQAFETANSPAPTTPSLSSENGTGRRSTPSDLSEIGNTASEGYANPRHSLSELLGRPNSQTATSAPTNPATHILSSVPPPRNPPIVTPVAPSPLSSHAHMNVVSHKSSYYRRDYDKQYDLTITEPISHDQRTQSAPLSLQHRVDRENHQDFSMHSASPPPTTSLSSPRIAQSSHVASLSPTTTQFPSPPPSSSATIHTTESSAHASPLQTEFNPQFRHHSLPSPPLQARPQFRSPPSQPPQFRPTQFDEQSSQSSHSHSPANDVQSRPRSPQMDVDPHPESRYPQEESFGSARTGTGSSALGQHRSVHANQQGRNYHSHPPSEARALYKPENDHLAREPVSPYKSGRMVTLLITDFRSRTEDHQLAEIVIPLRAVEPDTAEGGFWASAHDIADALQSSPSRIESPGRAYTMRGKWKQFFLRVVDGRNEVSSSANLLITPERTLDIGVIGIAPSELPSHAYGRPPVPEHAHPNRSNMNNRQHEAQYAMDPSRKRQRSPSEGGRERRPFSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXN4</accession>
    <name>A0A8H5LXN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXN4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="109" mass="11413" checksum="9D0C64972FAB2CB9" modified="2022-01-19" version="1">MSDTNTTSSAAGRKRRSARLAANDSGSVSDVENKPPAKKAKTQASTPSTSSKALKPMATGTKAAGAVAVTRTHTQAQRERLLMPQSELSASSPRAKLKSINSSIPNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXR4</accession>
    <name>A0A8H5LXR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXR4"/>
    <dbReference type="OrthoDB" id="3247165at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="60242" checksum="C37652766CBEB1E7" modified="2022-01-19" version="1">MYKISAKMATALNQPLLPFGGMNMIFAGDFAQLPLAMGGESVSLYSHIIGSNSSDQQASIGKYLWHQVNTVVLLRKNCRQTGKSDKDKKFRQALENMRYKNCTTEDISFLRSLISDPSNESRSIDNPHFRNTSIILTYNKHKDVANELGSKRFAAETGQVLTHFLSDDEEVIFDEPPSQTHDRKRKRRKATKHQIDEHVQQLLWKQLPSSNNIQIPGTLSLCKGLPVMIRFNGATELCITKGQEGTVHGWQARKGKCGQLVLDVLYVKLEKPPTNVQFKDLPLNVVPITPNTRHINCKLPDDRIIQISRTQVEVLPNFAMTDFASQGKTRDPNVADIYNSRDFRAIYTALSRSSTASGTMILQGFNVSHITGGISNKGGYHQELRELEILNDITKLCVDQKLPPSIIGDLRGPLIQQYRSHFGNKHRPEGLHESLVWDASEKFESTLDKDISWMILEKEKTKYPAKKKQSGTFVPIDMNILDRNEMKEESISILSKDIIKTHQGPSHDYPTLKWSENSCAYDSAIMLLYHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYQ5</accession>
    <name>A0A8H5LYQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYQ5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034916272" description="Lectin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="41994" checksum="913329953C3E60AC" modified="2022-01-19" version="1">MTLLLGVTLLFATHNTQAAWVSGHGGNGVSLMRRQDPGLDFLLANWIWTNEVTAGSVGDAPVGSRPFRKSFAPPQGKTPSHMNIAVATDNIGILYVNGNQVIVSPDWLNPQTSCVPLISGTNVIALNVTNTAVPTLNPAGLLVSADFFYTDGTSSHIVSDSSWRFTAPTIPVGFQSPTFDDSRWSTAISQVGYPSSPWDAITISPLVVGNTVTFASSQFIWTNELPGPGQDVPAGPRAFRRTITLSPSTVSVSAEILLTVDNEFSLYVNGRFIGSGTDWEVASRFAVNDIQGPNVEVAIFAVNTLPGPAGVLASIKLVEQQILGCPTAVNVVSDSQWKAFSGTPPVGFQVAGFDDSRWPPAVAEGNVNSSPWTNGVTIPTGTTPAGTPITGAPGGPARHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZA7</accession>
    <name>A0A8H5LZA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZA7"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="673" mass="74374" checksum="5045228559672F90" modified="2022-01-19" version="1">MVRVKNVWNYIPLPAMLKLVWDRLTFNRITTAYIIFSLVHCCIQLGLQTRAFTINADAARSLYNLSVQANAVNNSVPVLEGDTLELCSNVVDADCIVVWDGSRPSNISSNVNLESASFPPVPIISTSSSATPSSTSSPATTSSPISSKVTTTSVTSVVVLPPPTTSAPSTSELSRPISEQQPNNRVSLPEDDEDEDSDSDDEDSDDEDDFDSEDEEEHSLGRRGLKIMATMLENGTTEVKVSGPGFTNVELSKSCVWALNWPVGILENTKREDVVFIAFQIWVLGMSFVALMNESIPHVIASLLTHVLATVWSSFQISHTANFRADFNRVITNGACGVPLLGAYWDERAKAEYATLALNIAALFVSGFLSWKLFKSFGWLTFKRVGASLTINRIYKLVLVLSIILQLALFFMGATVGLWIDSLFNGLGAEHAEHVTFYRSTSFIAFLLLIPWIALGWIGVRKERRLPMFGFLVLSILYLGAWSTMFFSDTFRWLYLHWTFFCLVASASVFLTLSAFIVGLVCRYNFGKGLPRYLEAHEPLPGDDFAPVTGGSDIEKVAFPSEAPLPTYSAAFGKEVPPPSQMFPARMGPRFFRTTSEPFETPSNRSIVTVPSVAMTRTNSPDSTERTLNRSNSKSSERSFGSLASYYSYGSNHSRMDSSDTHNTMQGKRWVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B1Y3</accession>
    <name>A0A8H5B1Y3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000507">
        <property type="protein sequence ID" value="KAF5314227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B1Y3"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5314227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="17497" checksum="D2358EEECC1F9264" modified="2022-01-19" version="1">MATVPRLTKTHVKGYPQASVKKVAISGCDFAGVVIEIGLELNGAYAEYVNACPWTTIKLPDSLSFEDGSQLTACGLTACQALYQSQNLPSAENPITSPSLDLLVWSGSSSVGHFTIQLAKLGGMRVIATASPKHFDRLKALGADEVFDYRDPEVVKKDSSLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7W2</accession>
    <name>A0A8H5B7W2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000475">
        <property type="protein sequence ID" value="KAF5317603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7W2"/>
    <dbReference type="OrthoDB" id="3112770at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="15083" checksum="FF615F28BF54F166" modified="2022-01-19" version="1">MVFLVFHDWVVRPVSARVKRDAWVYVLSFRNGKACKIGCTRRTPRHRLQEWRCKDKSKGFKLVYLVRVSKERMFGIEHEAHQQVLKYTHKSNGACPNCSSKHREEFVFKAAFGLRDACDAVDRARELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BAZ4</accession>
    <name>A0A8H5BAZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_019002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000425">
        <property type="protein sequence ID" value="KAF5319875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="303"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="755"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5319875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1658" mass="189205" checksum="73F4F5DA35423807" modified="2022-01-19" version="1">MISHVIAFDSPVTKVYDILPPPPDELDEVLAIMFTGPCKPTEKDYQRTPMLVRRRYVYNALTWLKLNHPAYHDLNISMENLNMYAENIPPVSVEWKPTDNEGNRIPEGTSVHDNEPEIGTEQGEVPFVVHGLTGENLQNETVESQKAKALAHLNAQGKFLAVGHSKESSTIFKNPKLYPSIFPWLFPYGLGGFGMNNILKFGEKAHKKFLLNYHDKRFQTDITFPFVAFSHEQIKAATSNGFAMTELQSFPAIADRILNINHTVLTNIIQRLERGEMVRPETEEEKACFSIIQDLDHVGGGVKGAPSWYITFAPSDTTHPLCLYYAGTHEKFQPNLKLPDDDRTRQVIRNPVSGAKFFDFMVRMFIKHILGVDSGHDGLFGKTSAYYGTVEQQGRLTLHLHMLLWIAFSRSPQEIRDGILDPNSDFQKKIVEYLESVHTDELMDMEVVNENDSDAESTVSDTDSDISLESDEEDDDACEAEYLQGPKPMNKETLSQNMFPFLHGHPLADTHAMKVGSNAKRLVPNFIGGTLPRADKGNREYYCTVMLTLFKPWRNGKILKHEDQSWDDAFTNFQFTAQQKQVLKNFQVRYECLDSRDDYNAQRKTMSNNAVDADIIEYEPEYDDGIDSELLEISDECGPFERRRQEDMNEMTGILVGMGWTDNLHDRKSLIPQECQPDVTRSAHSWKLQINKMRQDILDKRHKSSANQDTANKFKNRFPNQVEILDKTAFETKTRQGQTQNLIDTIANEYKFHDNPEQNRAFRIIANHAASPCPEQLKMYIGGMGGTGKSTVLRALRKFFAERNESHRMLVVAPTGSAAALLAGSTYHYMFGINSKSEGENHSTSIPQICSRLEGVNYVFLDEVSMLSCKDMYKISAKLALALSMPHLPFGGMSMIFAGDFSQLPPAIGGESVALYSHSIGQSPKSKSDQENSIGQHLWHQVNTVVMLRKNMRQTEQSERDDKYRNALENMRYKSCTPEDIAFLRTMISNPCQPEKSLKNENFRNTPIILTYNKHKDVANRLGTERFAAETCQKLTSFYSEDEHVILEEIPEDQRQYRKRRRSKRFRVNGKIQKELWSQPHSYNDRQVPGRLDLCLGMPVMIRYNSATELCITKGQEGYVHGWKAKTGKHGKLVLDVLFIKLHKPPNPPAPIKFDGLPENVVPITRNTVRIECKLSDDSEIAISRTQVEILPNFAMTDFASQGKTRDWNVVDIHNSRDFRAIYTALSRSSCADQTLILQGFNTNLLTGGIKNKGGYRQELRELELLDEITRLKYLGILSPSVFGDRRSSLIKSFRTVQGINFVPASVHKSIEWNDSDPLPDTFDSGETWQIISADNETDQKNKRQLKGNFKTAKGATQNETKGRTLKRKAQAEEPERPSTTPKKKIKEDVPAQIQRNSASYLSYPSLRWFLNSCAYDSAIILLYYLYVNHFEIEMSHFTQILFMDLLDAFRSGITDLTAARENVRRGLHNIDSEAFSYGQYADAGEVLLALTQSDLSFSRSQVICTNNHVHKPWKNRTNMLLYMSSRMYQSTQQWVDNFVQPFGWQCQICHTELQTVIEFTRFPKFFLLYVPINASMEIDRMINLTVNGNQKPYDLKAIIYFGEEHFILRIFSNQAEYIYDGIKNGVPHKASILVNGTESVTYYDNKKAAVLLYGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BC67</accession>
    <name>A0A8H5BC67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000413">
        <property type="protein sequence ID" value="KAF5320373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BC67"/>
    <dbReference type="OrthoDB" id="2640035at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5320373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="32316" checksum="59C853CD5E642B6E" modified="2022-01-19" version="1">MEALLPTSSSRPQGTLIIPQCSSPKPIPYPPPLAPSPPQPLSYDSGTTISPRPVPPHWQIDREDNFLILRILFRIFCAIGHGQDRIEKVWDIVTNEIDFSDHRDRLASRYSSLAIMGALLITTTVSFLTTEPPRPDIFNYKERTPYLFTGGAIYATFIGTIIASAISWGLSKCSSWWYCEVMMATELRVFITIFLMAVPFLLFGLATLMEGIGAMIAAVNSGDILAIIGSVLMGSFMVVLSLLVAWIHQPYLVNAVQEMKNESNLKSTSNVDSSHERPPAKHENSTPSTTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BGW0</accession>
    <name>A0A8H5BGW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000398">
        <property type="protein sequence ID" value="KAF5323165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BGW0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5323165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="82" mass="9705" checksum="3348E9148D9E7282" modified="2022-01-19" version="1">MNAETTRWILVCAAPEATLTSRTLHFRRRSSYLPPFPFYLLLYPFTRTDPKFLTSSMMDNKNTERVPICHRHLILWRGILPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BKL6</accession>
    <name>A0A8H5BKL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000385">
        <property type="protein sequence ID" value="KAF5324960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BKL6"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5324960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="746" mass="80294" checksum="D598F8E07A2271B9" modified="2022-01-19" version="1">MDWRSTSTSLAGADGGVETIFFDVDIRTIGWSSGLALAVLDDGVQHLCVLRPFSIFPNFLLFSTFTPVYVLLFLFLFLPSTINLTNHSLFSTSTGFTNSSLFTGDIEYHNIPSGAGTYWIQSLTTLTVNSQSVSLPPSSNSESFAAIDTGTTLIGGPPEIIDAIYKNVPNSQALSGNSEGYYSFPCSQSVNSAMGYGDGGTAWSIDPDDFKAFEIGSTGMCVGAFFALDLGGGGSGGGIPSWIVGDSFLPQIVNFLESRFVLWFSLRPRRQVSFPLSLSLTASYSTFSSTFLALAFVFSLRLPSFSFAKNVYSVYRFSPPSVGFAALSDTALSMNGASSTSTSTSGAPQGNNANVGGIQAPLPSATTEVIATVTADPFSPSSKNGAIPTGMGTTGGVRGNAGNGGVTARLISMSGFNLGGLGYLAIPYDARIWFTLCVGMSLNPYHRYAELSLYFGGAGALLLGHTVSSLLFGILTLQTYLYYDKFSNDPKRFRSAVAVVWLLEFGHFISVFAEMWIDMVKNYGKVDFLVAIPRALAISLLIAAFVMLIYTLVFADRVYRMSKNPYIYSFLCIAAVIRAIIGIANFGAIWTSTSIDGYLHRWRWLIPMQLGFGLLTDAVISITLVVYLRRRDGNMNPRTTRIMDTLMWWSIESSVSTVVLGIASLVTILVLSSTLVWIALLLVITRVYSNVLLASLNGRAKLREINSGGSVVLRTNPTTISAPIELQSGSIYPMSPIESKSYGTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXM2</accession>
    <name>A0A8H5BXM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000327">
        <property type="protein sequence ID" value="KAF5331320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXM2"/>
    <dbReference type="OrthoDB" id="2542103at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034884978" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5331320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="266" mass="29094" checksum="9098061573C8B2CD" modified="2022-01-19" version="1">MFGLIRLFSFFLILEGIVAMVSPYQNQTESHHFQAPGEGDVRSPCPFLNVLANHGYVPRSGKNVTIPDIVKGGREGFNVGPNFFRLTGKKGLLTSPNLDSFNLDDLNLRGCIEMDTSLTRPDAFFAPNNTNLPFNETVYQTMASSNPGVDYYNVTSQAQVQDARLNHSIANNPELVNDATSLFARSAASALILSILGDPKTGIAQKSVVDTLMREERMPDGWKRPEDVIDVDTIQPLTQAIMDASNWPGPNNGTYPGAQQLVIFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZ17</accession>
    <name>A0A8H5BZ17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_016869</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000317">
        <property type="protein sequence ID" value="KAF5331809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZ17"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="147"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="474"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5331809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="727" mass="81054" checksum="7B0FC739AFD0817D" modified="2022-01-19" version="1">MLSVLAYNGLRQPNTCRTAFRTANLTENLTRSLSTVSSKGLPWPKDIRLSMPMRRLHLDFSTFTATHTGLHCRRRLFGHMARDTKAEGKPQEAKQTPTSDASSSLASKESEVQISAKEERRNNWKIIRRLMANVWPKNDWKTRGTVILGFVLLISGKVLNVQVPFIFKQVVDTLNIPLDPTSSASVWTIAGTVVLGYGAARIGATVFGELLNAVFANIGQRAIRRVARETFEQLLNMELKFHLTRQTGGLTRAIDRGTKGITFLLSAILFRIVPTALEISMVCGILTYKFGWDFAAITAGTLALYALFTIKTTSWRTRFRREANSADNKAATVAVDSLINYEAVKHFNNEKYEVAQYDKHLRDYESSSVKITTSLSYLNSGQNIIFSSALTMTMMMAAQGVLNGTMTVGDLVMVNQLIFQLSLPLNFLGTIYREINQNLLDMEVLLKLREDNPPIQDPPNAPPLQLANGTGSSIRFEDVSFSYLPSRPIFRNLSFTIPAGKKVAFVGPSGCGKSTILRLLFRFYDPSSGRILIDNQDIQQVQLDSLRRSIGVVPQDTPLFHADVMHNVRYGNLEKGDEEVIEAAKKANVHDAVMSLPDRYKTKVGERGLMISGGEKQRLAVARVMLKDPPILLFDEATSALDSHTEAELMRNINSTLLDKSRTSIFIAHRLRTVVEADLIIVLQDGQVAEQGTHEELIRKGGLYFRMWQQQATADQLTEESDSSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C358</accession>
    <name>A0A8H5C358_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_017487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000261">
        <property type="protein sequence ID" value="KAF5334355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C358"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="167"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="790"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="5">
        <location>
            <begin position="797"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="833"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="919"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5334355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1212" mass="134522" checksum="E0E02F0E6650EBE2" modified="2022-01-19" version="1">MGKKRFGLGKGKTPGKERKETEAEQQPQAGDTETVGSREISIFKSIERFMSRSGRNSPTISPSTVPSEKNLSTPAEQGVERIVREQPSTKGLATQSSQQIFSNASDFEIRNAEVNNIGGDQINIVNNYAIGEVALTKLKGELQPVLNPVQKTDECLEGTRVQLLKDLCNWVVKPESKLAWVFGIAGTGKSAIAVSLAQRFRAMNDDLKLALTFHCVKGQETSKVSSLVPTICYHLAKVFPEYRVKLAQKFEVDASLNSIGLPLQQQIETLLDRTLFYSQSTLKVVIIIDGLDEWGSSNEWKILSESLIALCFQFNWFRVVITSRPQTEVDKAINASVAVETFDLMKRYHADEDIHLVLTEGLKKPATWSIVGSHIEKLVEKANGLFIWAKTVQTFITGGMDEIGRLQLILGLPGEDVEEGNPYKELYILYAGILQESFQSPKDQSHFRNVMAVLFAVMEPVSPTVLSKLMGSNSPWVVEKILHVMKALVYERDGKLYYHLSFKEFVTSSLASDGFSCQLPICHQFVLNNCMSILKKELKFNICDLESSDVKNASVKNPPLQDRIQEKVGAHLQYSCMHWATHLDRAGNRADEILDSVGDFMNGKWLIFWLECMSLLGRMYNLKENLSSIALWAKSIEDTKIEDLAVKAARLMNAFTLPLNESTPHLYVSALSMVSQLNWFDIVRKHLKKGVQIENFDLSSQLLTINAKSEVTSVACSPNGRNVVSGSSDQTVRIWDTETGKQVGEPLQGHTDYVLSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTDYVWSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTHYVRSVAYSPDGKHVVSGSDDQTVRIWDTETGKQVGEPLQGHTHYVWSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTHYVWSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTDSVWSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTDYVRSVAYSPDGRHVVSGSSDQTVRIWDTETGKQVGEPLQGHTDYVWSVAYSPDGKHVVSGSSDQTVRIWDIETGKQVGEPLQGHTGYVQSVAYSPDGKHVVSGSSERTVGMWNTQVLHDQAFTSYAHSPPNEPCNIDSQGWLHTLQSDSKLILWLPPNVRGGFADSRQVLTIPSNANDFAVKVDWSNFVYGENWIQMWKDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3N3</accession>
    <name>A0A8H5C3N3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3N3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="70" mass="8044" checksum="A7F41CC632BF60AE" modified="2022-01-19" version="1">MTNILPKMEREGPQRREHDPDPSVMLPEGTKRAPKRKNPEGPTTVTVYLILKGLYKGLIIILFTRLYSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C478</accession>
    <name>A0A8H5C478_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000252">
        <property type="protein sequence ID" value="KAF5334731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C478"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="177" mass="19251" checksum="5DA424B737F2BD97" modified="2022-01-19" version="1">MKKQYQKLRDRFSRSRSRSRNRSRSPIPPAAASAPDPPVHNSSLTPSYLTSSGRLSPVPPPQIGDSAIQKPLPDLPGNNTRDGKSRLERVTQSTEFRSMKTLLKLVTAAGGAEPTGALKIVSGGLSILVEQAEKTVQTNADRKAFMKSLQSAVDNLEHYSRDVTSGSLGEHMKTLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9G5</accession>
    <name>A0A8H5C9G5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000213">
        <property type="protein sequence ID" value="KAF5337596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9G5"/>
    <dbReference type="OrthoDB" id="2853207at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="614" mass="69476" checksum="CCBB7D3E238CE4C5" modified="2022-01-19" version="1">MFSLRQRFTGIYLCIYLSDFHQFPSRLLVSQLLSVVVNPFSAHEIVAILLATFTYTRGCRPSSHVGSIWTGPGPRLAWRSILPGLGPSTEIPLSRNNFVFLQPQLRCKHFKLIAFTIVKASLAITISTQKLDILQLLHNNFGASDTSDIRHFSQCLVDAECDAQCCEEEIRRLEANIIQLQNKQQFARRRAEQFSSLLAPIRRLPSDILGRVFSLLCAENSIYLKLDLPAFCLSQVCAKWRKLVLSTPSLWSSLYVDAECSRPDEHVKALVDLYLQRSKHHPLHLRLSMLRETSLASDVLKSISAHSARWRSLSLKIRPILLKEDNFPSVKSNLPSLTRLRIWQLRLQPNAGSFEVFRIAPMLKDIAISANPWISIPLPLGPDIWLTFHSCDVRDAFQYLTMRATEVRDLTFSECTNFPDVPDNVTLHNLHTLTIAVHYKSPNLSFFLDSLILPSLTKLRLSLAKGHEPVFFEYTHDSMTSFLNRSGCSITSLELTNLRILDGDVLSLIRILPSLTSLTMHGNMEGEPLLPLLPRLKQLDLRYYADHSFPRAALLDMVRSRWLPDAQQSSEIGVDCLSAFTLRPIGNVSDSDLRPLQVLRAARLRVVIQGAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBL4</accession>
    <name>A0A8H5CBL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000200">
        <property type="protein sequence ID" value="KAF5338116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBL4"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="32146" checksum="4E8E789947641972" modified="2022-01-19" version="1">MSTSSSSYTNTSFAVLGSNGAISPYVIDALSKHPGVKKLIVLSRPSSSQPANFPANAELIPVDYNDHAALVNVFTKHSTEVVVSTLPHTATFDAQQKAARAAKEAGVKFFVPSEYGSVTIGLAEGNPLASKDRFAEFLKSIELPYVRYFTGLWLRYVPWIIGYDDNQKVNVIGKGESPISCTAEEDTCGFIAHTLTTLPPSQLSNAHFRLEGDRLTIRQIAQRLNKPINPVEVIPGPESELRTLVAKQYDTGAGSTGWDHGKQKENPKDSEEGAGSANKFWEGHVWKKLEDVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCA8</accession>
    <name>A0A8H5CCA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCA8"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139516" checksum="208970241A83045F" modified="2022-01-19" version="1">MNPDITNGNQVDLPIQISSPSQHDRGARKTSLLSARRPPPLQEQPRRRSDESNEVQRSLSMEVPSPEEVEDGGIRTSLEIDMKGLVGDAVGNMSISPASRDVVLAARRGLFIIDLEAPLEVPRFLPQGGTWDVADVQWNPHPSRANYVVSTSSEKLLIWNLDLAGKTSIEHILHSHYRAITDINWHTTECDTVVSTGIDSWVWAWDLRETRKPIFGLCAFNSPGTQVKWNRQDPNILASSHSNRVLIWDRRKGSLPITTLDGHTSRIYGIDWSHTARDEIVTCSLDKTIKLWNTSECSASSSFRAGSISAPPSPICEVRSGAKCTINTNYPVWRARNLPFGRGILSLPQRGETALEMYAISDNQLGGSAAVKTFEGHTDVVKEFVWRRGGYDNGGYQLITWSKDRTLRFWPMDSEALRKVGYIPPARGRSSSSGNSKVRDHTITNTKSFRNLSEAAGFLPLLSAPVGNRAILAEVRAGIPLRRRNDSITNQQPNLALQKTFTLDVHPSSLVSGSTDTIKLSSTLRPFGPLSATGGTMSRGAAGNKSRANVDALSWLSSVKVGEGRRGSSSGPQSRADSGETSRKNSKDAGKGESEEVIGEKNKRSESRALLPMEDRDTNQMLQDEITSVLNKLASSKVKLEKHDLTKKRTCTLGLQVPWGANSTIFLRITFTFPRDYPHASYPDGIPTVNLEHTPLISIQDRAFILRRLRTIRETRRPCLEACLRFLLYRNEDEKADILLDSESSSDEDEPGTKKEKEITVSLLRNNKNLAEPRTSQGSFGPNGKAPPRLVQNVIHTLSISSAKNSEPSPVVGDEPIPRLFQSPSLVNEAIRRLSQAASDRPPKPVDNKRPESGDHISRIMTNLLTFPHHRLRRESESVRSENANNQMAMVAPRRSTVAISNTTTITGGDRRVAVDYVFISHDILSLCAMNASVATSHGRYDHERLFKALGALLGTGATSAPSTNLLTKQMLQQIISTLRAQKDVQMLAMVAVIVMQRFPNYPPSQSISQVHSPGSNRLPSAIHTPKSLHSDYFGMTKSYEPPLSPTSRMPSSPQPISTSTSSKGSWSSLFNSGAMRQIMSGMQDTLKDGLINPTEIAPTAIPGKWIAVPRSDKIIRGPDSPLPRQRTPWKDSLPSTPAGVSKSWNETSMTSPNNPSFSSAGHRKSSFLHRNSSHRKPIKEKWAVVFRPVPEEESNEPMISDEERDLLIRHVHFYAEILFRWQLTNKRLELLKSVSAVDTHHPDTFSAIGKWIFPFHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDH5</accession>
    <name>A0A8H5CDH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000188">
        <property type="protein sequence ID" value="KAF5339076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDH5"/>
    <dbReference type="OrthoDB" id="3013340at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034731015" evidence="1">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="15884" checksum="07D0C1D711E8DC0D" modified="2022-01-19" version="1">MTSSNPGLPTPFLFGMALTFAQLDLLARHYFGNDFVDQTCLGDPAYAFDQIWEDRGVDNSIIEIPAHDGSLRYLYVLHVLSSSDGQPPKPAFKTQLLTKIWCKLGKPDVWKNVDVVCTPWSEELGITGGLTFAVLPNFHSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CER0</accession>
    <name>A0A8H5CER0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000178">
        <property type="protein sequence ID" value="KAF5340143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CER0"/>
    <dbReference type="OrthoDB" id="3014702at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="22797" checksum="DD63E52759EE7E86" modified="2022-01-19" version="1">MVRARHAKLGLYALATNNPKAFKIGLTTRAFSQRAREWARQCPSEGFQLIYGVNIHRRHLRIAERNAHRKMRTISIPTYRKPCKDSSACRRQHPRIQGSIEAVEEVRSTVRSLNGGSINVVFMYITFWWPAKRLGDGVGLWGHVKLGLLTIGRTFSFKLSLEGIEVLSMFLDNKIDEDCLLRLPPTPKSEYPSSFFAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CES3</accession>
    <name>A0A8H5CES3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001772</name>
        <name evidence="1" type="ORF">D9758_014538</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CES3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="53" mass="5687" checksum="D96810E6A25E5C1A" modified="2022-01-19" version="1">MSVGPFAAFDPSELRVFGFTLGCTSAKVSVKEVDICVVWQRMVDTVSGDCGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHE9</accession>
    <name>A0A8H5CHE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000167">
        <property type="protein sequence ID" value="KAF5341334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHE9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="160" mass="17394" checksum="1CE39FE3F4324A8E" modified="2022-01-19" version="1">MINVVDVSGPPKPIEFELYLNVVLDSLGIERTTMSDTVYDILFAGGGTAACLAAGQLAAAYPSLRILIIEAGEHTKNLDAHTQPVQYFSHLAPTSKTVDFNVGKPSENIRGRSLITPSARCLGGGSSVNFAMYTRAAASDYDDWETVHENPGWDRRIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CIE9</accession>
    <name>A0A8H5CIE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CIE9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="38846" checksum="FE35F85E1C72C4A0" modified="2022-01-19" version="1">MHIPAAVAVGVPAEATCKAPQTQADLNLTLLPCQGKPEQENDIFSCAAKFLNIPGLDSSIEAEEFIADSTESYAIQVRQDVSDSTKAQVIENSIAFAAVLASTPSTFNLRHRHSRSRSRSSALPTSVPVISEFPRPTAPLSSSPSTPSTITSASNSASNDGTVPELSGSTSPNDNNTTSSSNSSKTKASIAGGVVGGIALCASIVLGFWVWRGRQEKRLIKVQDPFNVQDSSSTDALRGPQKEHWTTNAKGRQFISVSTTQRQDLCRERDAPQAEMQQINSEIRSQDGSGNDSGQLHDMEARMREIQARVDMLTSEMAQVNRLMAPPSYVSDEGSEAQSNGTTGMEISGSDQPRNIFKLTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJN7</accession>
    <name>A0A8H5CJN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJN7"/>
    <dbReference type="OrthoDB" id="3263055at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="810" mass="89405" checksum="46A5A4FDF984AF89" modified="2022-01-19" version="1">MAPTVDVRYSIGPMFFGMVFGLILWGVTCIQTWYYYDNYKYDTRAMKILVGLVFLSDTIHQGIICKIVYTYTISYYGDIVHASAIRPGIYIEVIFNAFTASMVQCFFAYRIRQFRRDNLLLSVLGLCILGGLAVSIAYATQGLVQHLDDTMKLKHLKGLSMSINVMAVVTDLLISGSICTIFNASKTGGAWSDHILNRLMLFSINTGLVTSICACCSLLFIIVLKNNLTYISFYFIIGRFYANSFLATLNVRTRLRARVSGDEISHPKVVPFSSMSSVRFGQLGFERSTTNINTKAVGLELTSFASGYQHQHYRDQRERDKYSTATGTSLSITNPLASSTIQFGSTTVCPSFVDEYRDSLNDSNGNIELKPRQSTIPIPPPIETWTYPPWRSSPISTSRDRDSHKSKKSDLETATSMSFLQRRGTGLSAVITRPSPPPKVWDRAHCLDRIGAGGGGGGLVSGVELKDNHTQAQAPGQSDPGKIYSSSHRQPSRFSVVDLDIRGEPDTSEEDINKVTSANEDIPELNLDLESPTDEEQDDFLSGLGSRILPPNRVGARFRSNSDGPSSSRRVPISNRDCRVLDSRSCHSSISRLSPLTSWRSRASRDDELEFNLDRDENLDHVHRVTPQQQQQQRSSQSYILTDMNAAIASGSRTPRSNREVGVYVVADEAFHGIWANGPGDDSDTMDMAMADSYTYDPSYLQYGGRILSSGRPLTPGPNSINDRPVSRCAVERPRSETKLSVEDRSSLSTSGSIASEHHTQPPRLALNTNVGTPKPDDLSSPISQADSIATFGFGGQSERSWSSEEPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK86</accession>
    <name>A0A8H5CK86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000144">
        <property type="protein sequence ID" value="KAF5343280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK86"/>
    <dbReference type="OrthoDB" id="3039972at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="328" mass="35603" checksum="6701E77B10BEB939" modified="2022-01-19" version="1">MVLSSSESAPYLGLIVSLALTGVLYGAYGILFVICMYIIRCRKGTVGKAHQIALIFLFALATLGFIFGCIESTMGVSALGSVQALRLVSEDTHTASITTQTIVFGLYTLANTIADIVLIQRCYRIWGFKKRIIVFPAFISAVNNGLALVRTIAMVNDQVQDINSLLDTMEKVDGLGATTFKSFIGVNFFMNLLLPLMMAGRIWWIARQASKCIAIRKNSLTLSRLSLAVCLESGIIYPVALLPPLVIYLRQDIYRNAIFINLGGDLIPILIQVVGIAPTFIIVRVALGTSIENVQDTIAREHAATVAEQESTGLATTFVNEESAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKE5</accession>
    <name>A0A8H5CKE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000149">
        <property type="protein sequence ID" value="KAF5343098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="850"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="882"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1461"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1529" mass="161477" checksum="AA63A4D85E047A33" modified="2022-01-19" version="1">MSSSSVTSVSSSPSSSAVTIPIPGKSILKKPPPPQQSLFSRITRFLPQSSGAAGGNGSGSNNVNDEGKPLKRAHFILPEIAVVYPISNLNPPSMPTLKEEMRAIEEREYERRRKVVGGSSDTTYWTLDKVESFYRECCAGCDERPDPAISAALLSARPTDPVAVDFSGVQLTPASAGILADVFTIEWGLRKLVFRECDLDELTLKPILHSLLIPNSLAFLSVASNRRIKLPAFRLVAAFVYRSTSLQFLDLSQIPIDKKSAELLVAALTPAGHPGLASLRLDDCALKPGALEVFAKVVRTSSLKNISLRHNKINQTGAIALSVMIRDYPDAVPMTGLGLGLTADSSSNSSSSGSTLVASPRGSSPSSSLTSSPASSVLSLPLVGSGSGTPTGSTQTHTPPSHPYLHPTPSQPQTQSNHLPPPPPPRHPGTQPTQPAPAMATTYTPYVPRARRGVHVPPPLASSSSAPHSQPHPRSPSTLTHNVPIITTSSQGGVTTATAPTVVNGRNTTTSSSVSSTGMSSFQRKLNASLSGMGITIGSSSNSGSGLDSSSSSGRSTPLSATSPIQTSRPYPHPPVSASIKHPYPHPTSTLHHTSMNNKLLPSHPSQHPAQPTTQHSQPHIKTHQPSQASLPSLALLDKVRALDALPRLGSLRTLDLRGNDLRLGGIGYLGQVLKRNRTLKVLNLSENKIDAQGLVVIAEGLKYNGSLETLDLSRNPIGGGVGSGTGTGTGGMSGHGAGAGGGLEGIHALRTSFTLNTSLKRLFLSSCSINSAGAICLAEFLPESRSLLHLDLTMNDLGVAGVMALNEGLKKNKVMRCLDVEVPPGDEGYARLCREILNTCIRNTEEAERLAQAAAEGDTETEAEGENEEPNDSPSTLPLQTGTDTPGSSSTPVSASSPLPSQSSTPGISSSSSHPRSLSTKSSQSSLSTTSSTGSKTTPGSTPTGKAKPKAKSKALWGMIEDSELAKAIGLQDALADAMRSRSPSSGSVGGNEDDGLGSLGSSGLADMDKYVVARARKNIRLMKEVVEKGGFEGVVSALGDTQPLEDNQKEKVGAAGESELFSVSPFSPTIAEPRLGSSSSRLSLSWGFNSSTTFTSRPCTPIPANPDDLVKRIKGIVDEMTALIERVVEGAANSSGETQGVRVEELLDINDEMMGLLGKVEGLLVLEKEKWAKEKERKAEAASQESSQSPHVEDESCSDTSSSDPNIKAPRPTLKLQGLGIRLDDGEVGEQKEKEKEDKLPSIANGYLHPRSGSSSSSSSSSLGDIDESEDEEPSPNTPRVDKGKGRAPPEPIQHERVLSPTSVLMMNTMPPEMDEEEENEEENRFPRFYGDDAEAEGEGEREEYEEDEAGNEQTERSKSWVQEEGEVFRKGNILLGPEEMEGEYAGEELRRELLEAMVERPAPRDLTDEFGQAILADPAQDGFYIPSAPEPLPSISSSGSTTPIGTPTTEKPPPRPYIPRSRSASSSSSIMSLVSPSPELVSPVGMPLASVPEGQAGLTSSPVTGPITPRPYVSRKRSTSSLDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL83</accession>
    <name>A0A8H5CL83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL83"/>
    <dbReference type="OrthoDB" id="2585179at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="14486" checksum="9EDDA47CC0180B44" modified="2022-01-19" version="1">MSAKYDYDHNTYIAVTLDPQSSFFSSPSTLSEIHPALTHVGQVGKLKDVQLISFVKADWEEKLEEIIQALQSIEGVIKVDVQEVKDLTKRWSAELQARKLSQASIKMDMQESKAPEEVSKTECSSQQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLJ8</accession>
    <name>A0A8H5CLJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5344016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLJ8"/>
    <dbReference type="OrthoDB" id="1534087at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="445" mass="49797" checksum="1D27E3311D338469" modified="2022-01-19" version="1">MLIFQRINQGDLLLQTSQFPAVFTGRTNLVKEAVSILYETNQVHIAILGAGGIGKTSVALHVMQNLLIKEKFAERCYFISCGMLPDAINLIQGLVQAIGLQVAQGKGPLDVLLAYLKGDQKVMLILDNFETPWNSKGQTEVKNLMEDICSAKSVSVIVTMRGTDGPGQIKWHKLGGQSGLPALELSAAKEAFCSFSSNGEYTIKEEDPILEKLLIQIDGMPLAIMLIGELAKELPLNDLMEMWNIQKAAVLQKIGEQDNRLASIEVSIQLTLNILGEKLSATGEDVLVFQGTEHLEDQIWNFYESFIDNLPQDSIARDNQLEQHIGNIFKILEIQIKRSFEKSHTKVLRKLCNYTKYYPGLLPLVEKHLEWKSQMILSDQTEMMFLQESILSFMGEYGKAIEVINCVEELYKSQINEEAGNLNVITSTSSISMNNTIERTQAKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNY1</accession>
    <name>A0A8H5CNY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNY1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="36" mass="3975" checksum="DD721E1112C4F3FE" modified="2022-01-19" version="1" fragment="single">NGKPLARAAKGTVNKAASLKLYEREIEDIYVKAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP19</accession>
    <name>A0A8H5CP19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP19"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="613" mass="63974" checksum="7A9321CBA94A69BE" modified="2022-01-19" version="1">MGMLSKLLTYFRQIEIVRLLLENGADVNAQGGEYGNALWAGVYLDQVGIVKLLLENGAYVNAKGREHGNALQAASYEETIAIVKLLLENRADVNAQGGEYGNALQAALYRGNIAIVNLLLENGAAVNAQGGKYGNALQAASCGASVDIVKVLLENGTVVNAQGGKYGNALQAASCHGSVDIVKAAASDGSVDIVKLLLENGADVHAQGGEYGNAFQAASHRGSVDIVKLLLENGADVNAQGGEHGNALQAASCTGSIATIKFLIKNWADVHAQGGKYGNALQAAAYRGSIDIVKFLLGNDADVNAQGGKYGSALQAASDRGKIAIVNLLLKNGADVNAHGGKYGNALQAASYRGSVDIVEFLLKNGASLSMLRAVNMAMHSRLLHGRKSVDIVKVLLENGADVNAQGGEYNNALQAASYDGSVDIVKFLLKNGADVNAQGGKYGNALQACSYGGSVDIVKLLLENGADINAKAGKMSMLRVVKYGNVLQAASSGGEVDLVKFLLEKGANVNIEGGKYGTALQAASVADSDLLSDYNYVKLVEILLDNGADINSRGGKYGSAIQAAAINSNQQIYDLLIQRGADGIDPIFTIFQEDPKIPFPFMENKSADSQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP82</accession>
    <name>A0A8H5CP82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP82"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114286" checksum="FA32DA58AD73EB3A" modified="2022-01-19" version="1">MAEEILPCQGCNLSCRNFYAPDGGDLCDCEHPRLQHHQPVPPPPAPLLDPRVCPGGSTEFFAVDQSLRGRTPCERCGAVYVAHSMPASGAAASSSVPPQQPAAGMAAAPARQSAAPYVTPPDFSQSRPTTRPQPAQSFTPPIFQPSSFTPPPSQPVPFAPSFTSNIPLSFASSSYTPSLSQMPPPTQLLVPRAAQPRNFQSLQITPYGQVAIPPPISTAIGRSSAASRSGSRRKATAPGMLRVKIDVGILTLPASNFQDIFPDEHGTRGGWRAPKKRAVEFLEGLEKLGLKMTVDDTFHRNATAAPTIDTMLETHMRAQGLKFYTPDDQPVPIVPDTREWCFLICSAKNPGHREILKDTNRTDELTWSQLLTSAEKYQDKNQKKWSLRFTSPIDFPIAKWLPGDDIMHDGLHFCLTHKAFAKHDIDSETPGVIQQASMSTASQLASSSTTPQPSISSSPQQPDDAFRVCQDRCPRERTEDDNGSEIDADEVTNVIVPVDTINPNHDNTLNPAGPDTIPAAAAEATARAQFRASLLAPVDFMDINTHTRALRDVRRSKLVETWQEWVEELARDHATVSIKGPTVEIVAKNLVTVMIALGNGEDIFTLDDGVEMNNFDAMAAFVPESYREIAIGDDFDNGGRGYWRRVFVAACEQFFSGSGVFGDCWQDQSQDGHFSPHIPDGLFGVPRSTLPVLRGFGLFLLFSMTWGIEVLKFSPMVVRMLLGGDPKNIATDTTFLMKVVPTLCKRLKSWPPLPLGQPSPGHNWDLDDTCQDPVLLLKEHAGLTYTQIQDITPAQAEELKMSIPLLVLFGVPFSQAETFSVSSPAIQAILEGFTTPAKLDVIFPDTVNNTDLDCVSLITEMWSGRMITEWKDVSRRIIWQWPVSDPEELPENAAELQKKWIACLLRWLYKSVGNCQRFVEMLSGSPYLPSPSDTSQLYKVVFHTKTSLTIPDVFWHTCYVTVDVRMISCDYLDGIDICPQDTSVVTPFDAWFDLMLRFIYFVSPHVLSHAFMFDILDLHEWSLILARYVTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQH7</accession>
    <name>A0A8H5CQH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQH7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="105" mass="11130" checksum="00748CA8DC0C6C9F" modified="2022-01-19" version="1">MSSPPSRSNSQGNNASRSLHGASGWSPQGLTSKLQLYISNLETTLLPGTVHVDSPPDLCELDSSLSNPGRLSGTQRRKYISRSPSSYTAVSTTSTTSSQFDSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQN2</accession>
    <name>A0A8H5CQN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase substrate binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQN2"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="42204" checksum="28559863A9C09D2F" modified="2022-01-19" version="1">MRLDEWSEWLLFALNMGNTTSSSTGSPDGNDFRLFGYPLAHSASPAFHNEIFAAMGTSKHYSIYSTSKVIPKMLTEIRSEKFGGAAVTMPLKSAVIPYIDAITPESRATGAVNTLVKVPNANGSVSIVGTNTDILGVKNSLLKYLRQQHPQTPISNSSRYPEGLGGAGVVFGGGATTRSAVYALHTMGLHPIYLINRDVNEVEQVRQNFPDLVDKGSLIHLDTPTRVEELLAQPDSPKILMIVGAIPAIPPKTKEERMVYTTASHILTIPYEPPVLLEGAEDSLPIPTKRLFLEMAYKPRITPMLQVAIAHGWQPIVGTEAMLEQGYAQQRMWLKGDPSAVTGSDPTILGPEVIKRAEMLIAGMGDIIATEPEIDRAANIDAAPIPKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQR1</accession>
    <name>A0A8H5CQR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQR1"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034349490" evidence="7">
        <location>
            <begin position="18"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5345346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="804" mass="88355" checksum="353D3971586B85D7" modified="2022-01-19" version="1">MKLFFSLLAAFLAGSNASPSVLPRQSSVRLAVSPNCGTLAGAPASVNAGLKDLSSFDTIVAFGDSYTSGGVADGSALAPADIVPPNPSAGGRISNGKLWVENLANVAGATLHDYAINGSVIDAMEFQMSSPLRQQKDFLGQVNSYLSSRTRPVNPDTTLFVVFVGTRDYENREDLTFQNFSLTTGAISYAIADLTFSSGVKNFLFVDNYGRGEKTSDGEAYKQALFDALKDAKAQMGISFAFADLYPIWNGVLGSNPGYEAFGFTSPGACIVDQSLNDACDDPDHTFYWISEYPSASTHSIMAEYVEKVITQFRKAGYQAIDRICDYYYELQQSKFPVVSQVEPGYLRPLLPSAAPDAGEDFQQIADDYQKYIVPGYTHWQHPSFFGYFPTGFSFEGLLGDLYSSSVSNPGFNWAASPSCTELESIVLDWAAQMFGLSPAFLNSSGTGGSCIQNTASDSALVAIIAARSTYTAQFPDAKLEDLVIYTTTQTHSLGVKSAMVLGLSTRALEVKREDKFSLRGDTLRTALEEDRKKGKKPFILIATVGTTSSGAVDNLAEIKEVVLDYPELKIHVDAAWAGLSLVCPEYRDKFYLNEINEIADSYSTNFHKMGLVNFDTSPLWVRNRKYLTDALDVNPPFLRTAAGDAGTTIEYRNWHIGLGRRYRSVKLWFVLRGYGVEGFQKYIRKLVSLRERFVEHVSSSDLLQLVAPPSLALAVFRIEPKQPNEALPEESLNNLNRLFYGRISARKEVLLTQTVLDGSFCIRFSVGSPRTQEEHVDKAFEILTHEARLAIESWKQDAAPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRI3</accession>
    <name>A0A8H5CRI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRI3"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="583" mass="63905" checksum="2E81D27CD18FC37E" modified="2022-01-19" version="1">MTREPIRHAHDSADANTASDDSDSSHLHAEGGRHKLSSSVSSLASSLHQHVQEHVHHHHHRQHSASSHSSRHKKNTHKKHKSYISAAAARHLALAILIGYLQDFWTWLSNFSIMPSAETPPVSATERSSLLSRIHSHHSSPQTNPPNPKTRSVVWSALTTFTVAALIVLLFFRDSLPDMWKLSPLLGGNPKDPMLAALGILDKAPVIDGHIDLPIVVRYAYANNVSATDMNSMPMHVDIPRLREGKVGGFFWSVYVNCAKPEDEGEDFLKATWRVRDTLEQIDVSKLLIDKYSDVGEFDSPYVSRKLSRSRQTFQLALGSQDIKSAIFNGKIASLLGVEGGHQLGNSIAVLRQYHALGVRYVTLTHTCHNAFADSCGYEPGKEPLHGGLSSLGMALIDEMNRLGVLVDLSHTSDATATQALLHSKAPVIWSHSSARAVHDVPRNVPDSVLRLVGTGEGQKDGVVMVNFAPQFVAPEGEADVKAVADHVVHIANITGKKHVGLGSDYDGISSTPSGLEDVSKYPALVAELYRRGWNKYELAGLTGGNLLRVFEEVEEVSRKLKAEGMLPIFDLYDKRPDLPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRJ9</accession>
    <name>A0A8H5CRJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="1566"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1733" mass="183328" checksum="32191B9AEE56668B" modified="2022-01-19" version="1">MMSSTFEELFTAAELDVRVPNASLQFPSEDNADPDKWLDDLEDSDRSQAFFDEHLEAILTIRLPDISSASSAANTPTTTTTPSPKPTSQLLRFLSHLQVALEASYIPQAPSIEVLRPEDTNKEYEPPLSPRPLTPTPRSPRSTTPAASPSSAAASTTELAVPPRHTSLKKPVNLSLGSPNSLAPPGSAPAGKKQPHHPSILPPANAESYACFRDLGCQRPATGGKEKDNEESAKALKKGMDEEKESFCLLWSPGERVWIAQQKLMFHLAPYHSLSTSSFLKSLLCLTVSTTLRDKPITSLDRYFTSLGLLPSPHTADSSASSSATISINSTTSETSTSTDEQELIIPVHPTLPQILPLKGPPEVNLFAGLYGISGFRASTESSPTNGSHPPNPFTASPTSATGAAGLRSTTKANGKTADADNQGTGVDILTLPSTRLGPSTRVDLFGLHPEPNSPTSFADGTPNPNASTATLTQSQGQTQTQSGGSRSQSQSRSATPSSLSGSGGVRHRPTSTQDKRELARALMSGFGSGRTTPSSSRPSTPTLVLSPTGSDRSETDSGSGSAPGTARMPIVSAGAGTGILTLKKSFRKTLGMRSGFKVRMRTVFVPSVLFPRNEDGEEGEGEDEDEDESEVEDAEDDDVGEGSEGSEDEDDEEDEDHEDLLASGSSERTVVLCVEVENDGFQPEIVRNDGDDPGPASFVIERVEVDVGASLNSSSKKSSIATTANGWGESGARTRLIGWDDISLSGDGSGWPRRNSNSKSKKSKKKKSKSKTKTKSNPIVSPPTPMPTQPPRPRLRFSLPAISVDTSQAHSQVPSHLQPNLGHPLYPNQKRKSKQFPLLLAPNEQHNLLYAVSFLRSPEEEAAESLVGLLRGPGFSGGAGASNTEGVSGMASGVGVGAGGMSALQRSVTINIFGKPCFKYKPRPAESEDEEDDDDEDGDDDDDEDDESEYSPTSALMTPITPLSTISTASSTFTDIMNLDDSGDSAKPRVPKQRRMMKPRRERERKERMTLTQISQETFVYPTSTFSTKWNCILDLSSSFTQPPYRNSSQLPTFSQMQSSKPVFNLPFDDEDGLGDGSGTYPSTAVLPEPPSPFPVSVSGNFPTSASLKALGSFPSPGGLMSPPVPSSRDRRSLGVDTGSGKRYSTPPDSVKRHTMPAPYGAGAGSQRPVSVVSAGLGAPRARVSLTPSLPPVPSGSIGEDIPPVPPLPNRRHSGASLPERKDSGGIGMGNKLRERRDSLLSLVSRDRDRDSLPPRSATSTPGQHYYTPPSVAQNQFLQNQYSHQSTPLRSPTTYEPPPLPEKDYPAQSIDYIMSVEQDYGGLNTNGGLGLPPMTPAYPAFNTGPGTSAVSGYTSSSGPAVAQTKVSAGRSSPSPYGHPFPNKAPLTAIPPTPPSQAPLIPQGGNFGGPTAASYGSIGGGGGGGGGGGAGGSHYTGQSVDIKRERGTFGSMMGMMGLGSALGSGGGMSAVPPTPRPVVGVEGGFGFDDAQGGGEGPSEGENIIVSVGLLPRSKMKAKTKGRRRQGHGHEEDSDQTNSESDSDADDTDTDVFNVNPDSNPDTKSDSDFIYPMDIFILDIFVFNRSTWTRRFEITCPDARIRRKKLEKETIMGLANNQGTKKNQRRSGATAAAALLTMEKEKIQGPGVLAMENRIRVGPLLPSACQSVRMKFLAVTPGVHAIDTLTLTDVESGFSMNLRSVMDIVPSVESSTSSSAAASRLQIPVVVIGVGNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CST6</accession>
    <name>A0A8H5CST6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CST6"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="369" mass="40105" checksum="666464A5887860F8" modified="2022-01-19" version="1">MDNLPAEAMHANPPDPSPSHHHCSLSCPETSGSGRSTNGPGASSALDSTASTLHEGNDLDVEKIEEAEGEKVTAAASDCATTGKEATELNAGGGSASTSNEVELMHYPDGGLRAWLVVLGCFMYGSSCMGWGLVWGVLQDYYHTDMFPESKLSVLSTIGGLMNFTMTAGSYFFWWNGRPIKMISIGCFLMYACLLASAFSTKVYHVFLFQGGLLGLGQGIALPLYVSLPSQWFDKRRGLATGIAVSGTGIGAGIESLIVRPMLVNLGLRRTMIIYSSMHALVWTIAWFLIKERIPRGRRANTNQTKKRWLPKKVTGSFYSVALSMFFGIFGYLSPYYFSSTYTRQMAPNIDPSSLLISIPLVLMTFCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVB0</accession>
    <name>A0A8H5CVB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVB0"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="350"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5348679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="76835" checksum="5C8CBA9FC358311D" modified="2022-01-19" version="1">MSPRHFASSEHPIWKPSANAPFASTEILRHSINRKHGLCLKDYFDLHEYSVNNYSFWSDIWQELGIVYSTPSEQTVSLGSLQDLHQASWFPGSRLNYAENLLRRNDDAIACTTINEAQVSTDYTYKELRNLVAEMSAALRVNGLSVGDRVAAVVSNSITAIVLALATTSTGAIYTSTAPDMGAKGILDRYTQVHPKFLFIETETTYAGTINKLDAKVKEVVQALVKSGLKLAVLLPSRASGLASPLRIHNSVPLDKFLATGDGRPLVFEQLPFNHPLVILYSSGTSGTPKCIVHSAGGILLQLKQQMFYGFDVGPQDTFFQYTTASISSSFLFLPPPTLTPDGQTGWMMWMLHLTTLSIGARIIAYDGSPFHPTVPAFLKMINQQSVSVLGLSPRFMSELQGKGIHPVDIGKFEALHTIAVGGAIFTAPLHEWAQKAFNQGKTGNPIRVFIGVGGTDICSGFAGSVKTLPIYAGEITCRHLGIKLEVFDASGKNIEHTGEAGEMVVTRPHVSVPLGFWDAKSQKAVPGTKFIEAYFNMFPGVWRQGDFIVTNPKTKGLLVLGRSDGVLNPKGIRFGSGEIYSILELGFGSVVEDSICVGQRRPQDSDETVLLFLRMRTPGSLNNNLIRRMNDAIRTGLSPRHVPNYIFEVKQIPYTTNGKKIEIAVKQIVSGQKPKPSGAVANPEAFKEYYQYYTTVKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYB0</accession>
    <name>A0A8H5CYB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYB0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5350284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="38386" checksum="43E5E9DB9B45CF35" modified="2022-01-19" version="1">MPRASKSSSAAPTTRRSTRLISQATVTTSASNKRLELSVTLPRRRRIAHPKHSTAFFDESSTSASASCHADDLKENNASNDTKSSLRRSSRITSSELLKREKNLLRKEQEYKIRLEELDRRSQSLSKREDEANALLAKVAEREAEATLAQLEEHFTCPLCYEILAHPYSLNPGACGHTFCALCILKWFFSRCHSLCGGWHESVDCPLCRSLLVITPEHTPRLDVTFPFVPNRTAATLCESLVGKLLEYSRSTRKLTVKREESEGVWGAGVDCYKKGKSEEVDAMEPESTGGLSEWQDGGPLRLDWVKRESEGKKEMVYLFENWTEMKPNDFAEMKHRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYG1</accession>
    <name>A0A8H5CYG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_007776</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYG1"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="206"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5350270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="565" mass="61173" checksum="E6C14D68BA07CE79" modified="2022-01-19" version="1">MSSQVNQISTKPFDGQKPGTSGLRKRVKVFQQQHYTENFVQSIFDSIEPQGVTLVIGGDGRYFSPETVQTILKIGSANGVAKFIVGKDGILSTPAASNVIRKYKAYGGILLTASHNPGGPDNDFGIKYNVSNGGPAPENVTNKIYEKTKTISSYKVIEAPQVDLSKIGETTYGPSKVEIIDSVEDYVILLKEIFDFPLIQNFLTSHTDDYKVLFDGLHGVTGPYAQKILVDTLGLPSSSVQNCVPLPDFGGGHPDPNLTYAHTLVEAVEKNNIAFGAASDGDGDRNMIYGKGAFVTPSDSVAIIAHWADVIPYFKKGGVKGLARSMPTSKAIDLVAQKKGLEYFEVPTGWKFFGNLMDAGRLSICGEESFGTGSDHIREKDGIWAIIAWLNIIAAANRDSPNKLVGINDILSAHYKIYGRSYFSRYDYEEVPSEGANAMVDHINAALKTGSLNNTTHTAESTGGKFTVSGIYDFEYKDPIDHSVSSNQGQVITFSDGSRVVFRLSGTGSQGATVRMYVERYVAPEAGEKELNGNTAEGLKGLIEVALKLSDLKKFLGREKPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZV0</accession>
    <name>A0A8H5CZV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZV0"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5350910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="57884" checksum="93B2EFCACE0EFCAC" modified="2022-01-19" version="1">MDNNGHPGPDLVGGPFAVIESDPGVFTSLTRKLGIKNIDFVELYDIEPWAVDHLKNLHGLILCFHYAKDSHRPADFEDPAAERVWFANQLSDDACATLAILNVVFNCPSLDIGPTLESFKTETSQMSSVIKGLAISSSSYIRNAHNSFARPADLRGALNTISITTLNAHAAAQKKAKQKAKESEKPPPKKRGRKPKEKTSTEKSAKNKPEDSSKNEEEAYHFIGYVPAHGKVWELDGFKSGPLEVGELANAHAGSSGVLDSSPSSSRLPDAPPAFLSTQGWMDVVRPALRMKMQKYGSSIRFSLLALVSGTYERANDEWEYWRRDRVVLERRLDEVDPGNWRSKVDPNNLLGAAEHAFTHPLSQSRIFAADFASRRNKRDMSILTMSAVGELCSEWEETVKNVVKAKVDLEDELSRAKRDHSEHLKRTHDYEPFLAEFVRCLENEDLLDDLLDLRFGGRKKASQNKDGSRGPAKKKMRGLDADDDDSKYKNDDEDWEEGSEEMIDKDDDDWKPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D363</accession>
    <name>A0A8H5D363_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="5">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D363"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012251">
        <property type="entry name" value="GlcNAc_6-SO4ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036666">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034364038" description="Sulfatase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036666-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5351337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="574" mass="63341" checksum="66C579409165C965" modified="2022-01-19" version="1">MHRRQKFLAGLALSLGFQVGVSNALASPPAQPNIVLILTDDQDARTDSLLYMPKLQKHITDQGMSFERFYAPVSLCCPSRVSLLTGQFAHNHNVTFVSEPFGGYTVFCKNGYNGEALPSFLQAAGYATYYTGKLMNGLDESTIQESPAKGWTSADFLIEPNAYLYYNASFSANGDPAVNYLGEYQVDVIQEKASSLLQTAISGLKNDASSKPFFLGIAPTAPHLEVQFDGSFTEPLPPPGDEDLFDGVPVPRNPNYNVHGGVSWVKNLPELNETVIEYIDHIYRQRLRTLQSVDTLVETIVQQVEEAGIADNTYIIYVADNGYALGSHRRQPGKSLPFQEDTLVPFIIRGPGIPSNSTNDVVHSMTDLAATILDVANASASYPVDGRVIKFDGENDGSGHTIVEYWNIGAEEGTYAFSSGTILGRTRTTYRSIRAVDGDEHDWAYGVWCTGERELYDLKTDPYQITNLALNSPLKGFDSFNFSTPDLTSLASRLDALLVVLKTCVGEVCRDPWSAIFPENSTSDPVTRLSDALSPEYDAYFDSLPKFRYKICRFGYFEENESPKWEDGLAYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3I1</accession>
    <name>A0A8H5D3I1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3I1"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52554" checksum="BB9B8F1E55FD4179" modified="2022-01-19" version="1">MPSSTKKARKNRRTCAPSPSRRNATTPVPSAVPRDEQAPSRKKARTGRTVTAHTTSKRKDTSPEPSPEPCPISNLPLELITLVIQQLEHDVASLKGCSLVCHGWRRSAQRYLFTSITLVSNDSCHEWNRFLRTSDYLGPYVRKLILRPEPGTCSFLNLRGATNVIERCPGIRELEIDTLQDQWHVSGQEFVVAKLKSVEILRVKGQMSGVDFGEILRALPALRIAEFHPERIPVTSRFRKLSRPSSPGFDSSRLRVLKLGWLTRPPGYANVGGPNAVPLLETFCRSHGPQIKSLTVFGVSVQGNSEGLRGFGSALSHFKNVEDITLTMSLKNFMYRDYPKHLTANPVGNAMRVLNFMAPCLQAQKFTLKLALRADDIGSESKWKCLDKVLADPQKFPSLRAVQLQVQLIHRINPRPEQLECHNSVAAMKKQIRTCMHKLLSSNRLHGKVTSKLYWYTMTMDDPIDCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D402</accession>
    <name>A0A8H5D402_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D402"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43154" checksum="C30615D3849A9DA8" modified="2022-01-19" version="1">MSSKKMDTETYNEDSLPQYTPMPYSLAQIRAAIPSELFVRSTTKAFAYLARDLLLAATFWHAATFIDPVCKSTKIVDLVGGWGAEVIRWAFWCVYWWFQGLTFTGIWVIGHESWSGVALQLRNSEFPNDPGDDQLLGSNFKRTIFLFHAFSENSFFWFSSSPFVLESSIFHVPTLTKVGGDVQFIAVAKWLRCGHGAFSQHKLVNDVVGFVTHTPLWTPYFSWRISHHRHHTAHASMERDEVYVPWTRKELGIPNEPSKGEHPPVYTSDDEEEHHHHHDHSHEKGGINYEEYLGDTPIYTLFMLIRQQVLAFPTYLFYNVSGQRHYPKWTNHFDPSSILFTPSQRPLVILSNIGMLTMGIWSGPHQNSTEQEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4L3</accession>
    <name>A0A8H5D4L3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4L3"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="1">
        <location>
            <begin position="2"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="2">
        <location>
            <begin position="345"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="68268" checksum="D35E321DA1A8A776" modified="2022-01-19" version="1">MLVFPVCPNKKSPEKKRSHGYWKDLLNILALAATDSLHITNPEFLHHPRGRYLSRRNHAHIPIVRIGQDHDMELQMQSRQKRVRVGSERSDNISSKLNGDPKFRALFIAVARLFGHQLIEDIKLVIEIEKIPSGSPDAVAVRRSLLERISLAGKWAPTPGAAHDRVTNIATVISLLLHNSRAFIPQPFPRSVENFDLSDTQVSSSSSIESLIILRSYYQRWFLTRIRNTTHVIEPLMCSNRWSSIRYGRVPSRCMDKNTNYFFNHDQTRFTEYLADVEMGKAGISGATLFPHELIKRVVEISQEVEGFGAKGTQAKLLRDAKSKVVEGQWNAIVQRLKESGTLENCIAVCDVSGSMGSLWHTDSGYGQRGRRQQHVPPILPAISLSLLVARLAKPPFSDAFITFSRFPEFVTLDPNLSLHETVVQMSQSSWGMNTDFSAVFLQLILPIAKAHRVPKEEMIKRIFVFSDMQFDAACNQRDRRDAVRQAEWKTNHDVVVKAYEKAGYDVPQIVYWDLEHSGTSTVEVEAEREGVAMMNGFSGAMMKVFTGEEEETQIGDEGWEEVNIVDGEVKTKTKTQKEEFTPLSVMKKTILKPCYDGLVVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D568</accession>
    <name>A0A8H5D568_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D568"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="39221" checksum="C8968026FE72B8DB" modified="2022-01-19" version="1">MSSKVGQDPFSLSDQRIANYFHLVGVVLLLWDHLLTFSMEFEHVWMPSKRIFTFLFFFNRYHILLANIVVTISLFDPAYLLWCSVDLYMSIYSLLTFKIQSCGGLHIFREISLVLSQVIVGVLLTLRIYAIYGCDKRVLGFMVFVAAILTGLALFALFFVPSSSSTAAVSLTPLGCHTNLDYLPHAAQEAAGWEALFVYDSLLFAMIIIKGYKNKRSMERMPLLHMILRDGAFYFAVMALANLANIFTFYFAGVREASTLISAKIKMFSFSAFYKRQSINLLKRDISNNDFTPYAQSAREYQITRESSNFGQCASFYAALWTKPRLLMFIVRVSISRGCGLNTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D575</accession>
    <name>A0A8H5D575_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="356"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1292"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5352936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1385" mass="155723" checksum="AD744E604398FE67" modified="2022-01-19" version="1">MLRRTRLLSRQSLPRPARFYSTPSRKASAALATQQVPHTQPDYEFITSSRPTRPHYSSSHSDLESFLNSPPRLTLLPTPRPDQSTSSQAWWFSDSQTQDLLAVMDACLHQLHDVPRAKEVFTRLRKEAVGASRRSVLDPRLYNAFLEAYLNMASTPGKGAANRDYWMESAWELYDAMESDRDGVEPTTGTYATMFLSILRFGPDSPSPIPVTKVGALSAKTLLQSLARRGISVENVVADRVFGSARDVDGSLEKGSREARGVIRILSRAAVDTGMLDIVHQLNAAEEKGQRDEADDVDEALAGVPEARAVLKEVKPDPANPNSSPTYEVPFNLENLRRHLTRVSFARRILPEDIVSRQKLLEESVYDVAVARLQHENKVFEDLGLGQDEKLRNPDLRRYMWEWHCKLQVKLKDVVKSLTTLDQEEPMRRRNKNYANMTLSPYLSLVNPSRLSLITILEIMRLSGSGGVSEGMKTTRALIQVGKAVEMEYKAQMCRKYGIWVPSSSSPTSQTQTGAAAATSGRPGHFSQLGYSSLQERRLVAAKHSMEAESWTAEWTQMIRAKVGGILVECLMEVAEVVRTAVKNGQEFHEVQPAFYHSYEHHRGQKLGVIRLNPAVSERIANDSVRETLHPRQLPMLIKPRNWIAPTTGGYLYSPVQVMRYKDSVEQAATLKKADREGHIEHIYTGLDVLGSTPWKINRKVFDVVLQVWNSGERLGKLPPVVHDEPEPEPPAPEDVSVKSKTNYVARMKSWTQAKANTHSDRCNVNYKIEIARTFLGDTIYFPHNIDFRGRAYPIPPHLNHIGDDLSRGLLIFADGKPLGERGMRWLKIHIANLYGFDKANFDERVKFVDDRLDEIRDSAEKPLEGQKWWSHADDPWQCLGACMELTAALDSPDPLKFVSCLPVHQDGTCNGLQHYAALGGDSRGAAQVNLAAGDRPSDVYTYVGRMAEVVLEKDAEKGEKYALLLKGKITRKLVKQTVMTTVYGVTFIGAREQIEKQIRVSKMFAEEDVWGVSAYLAKVVLACIGDLFTGAKDIQTWLTLCARLIAKSIDGKRIKEALEEYRAKKTSARSRKSARSPSVDFLRKEQMTSVIWTTPLGLPVVQPYRKPKRKQILTSMQSVYISDPNVPSEVNTMKQASAFPPNFIHSLDATHMMMTALECRAQGLTFAAVHDSYWTHACDIDNMSTIIRNTFIGLHSSDVLTRLHNEFMDRYKDYKIPLVHLRTGVLNKALRDAGSKMVLSPEQAKKLGINLSGKSTSSGLGKLVKISEEEKSSLDESEDSEKLKELLNELSADTEEVASSIEAKEDNAEEDEYTENDFDQEENDEDDEYESPRARAQRLRKLQEEKVSKDLMGKFVNLTDLIPPLPKKGDFNVQAIKASQYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8L5</accession>
    <name>A0A8H5D8L5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8L5"/>
    <dbReference type="OrthoDB" id="2688364at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="39565" checksum="A4A19EECB85851BF" modified="2022-01-19" version="1">MIEQAHFTSLPLDLLLVIFDWMSPLDIIHLRQCLGFCPQKHFSLFLPPGPHTLHPVSELERILVRAQRLDEDWCLESGAPQLKTIRELTYEQDIRCMHLYYGRYLINLKLEALIGINRYFNVTWNPKWHFNTIFGAMIRGEAFKAQRLGCILQSCRERQGICDPMELFYGRLMQVLTLPVEPYPITPVVISNGYLQQSWSPDDFIVLRDQVIAMHLHPRTKFECFAIYKQDETRTDDIRLQRTHCGEWDVSIRRPQALVYRPPTSSTDEANFIFVSVMPLQETVKLCLLEVILRQDGTISFNKIAEGNDTSYFLSADICHRERFIRALVRCPTFAKSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAP8</accession>
    <name>A0A8H5FAP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000339">
        <property type="protein sequence ID" value="KAF5329924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAP8"/>
    <dbReference type="OrthoDB" id="3056812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="157"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5329924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="449" mass="49405" checksum="C0F548DB2B7E41C2" modified="2022-01-19" version="1">MPFDQTFSNPSLTGESLNLELRDERGQVTAANLNLNTILGNVDGKLKWGGRDLMSTAQDLSLNGSILSAKLKHGDDILSDQIDLSFYIKNNNGKLETVYGSVNAARNPSTDAVSDGNRNHTAMDPPPAYHNSKSAAYRSYRTASNWSQESRSSTYFVYTVAADNLRLEGSVLQAECLKLDGTYVSQTLELDDHIGVVNGQLVWGRSKFHSICQNIRLVGYILHADYRDENDNTISSSLDLSRYLQCYDGVLGVKMTVNDAELTSFLREARWLKLRVIAESDASAVVGKNPAFKGAFNSIAVSTSEHVLAEMNELFAESSRDDKKGLVDKAKADMNRVVATSIPEGKKLSERIEAVFETAKREVIEICNDMIAASVNDLNNSFASILGPLADHFVGQDNGSEIMDAVREAISATIAHYQERAEILMEREMMAAATRGALHKELVFGEVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDN5</accession>
    <name>A0A8H5FDN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 15">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_016432</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 15"/>
    <dbReference type="EMBL" id="JAACJM010000297">
        <property type="protein sequence ID" value="KAF5332951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDN5"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 15" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="16">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="17">
        <location>
            <begin position="215"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5332951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="42988" checksum="C97AAEFCC53F2A19" modified="2022-01-19" version="1">MNLMAHFDPTHHPHRRFNPLTNEHILVSPQRSKRPWLGQVEPSQPSDIPKFDPTCYLCPGNSRAGGQKTEHYEHTYVFENDFSAILPPPVPIAPPASHPLLTTEPVSGGCNVIIFHPRHDLTIPRLPLDDISRIIEEWIKIYRRRGGEDGIKHVQIFENKGSIMGCSNPHPHGQVWSMSAIPTLPSVEIASLTRYASRSDLPPSDAPKGPDGHPCLLCEYAFTEVKLGERVVVKNEHWVALVPWWATWPFEILLLPYHRHIPSIFHLTPEEKLTLASIISQVTIKYDNLFLCSFAYSMGIHQRPVPLSSPEETDDHDICHLHLHFDPPLLRSASVKKFIAGIELMAEIQRDLTPEQAAQRLRTCAETHYLENGDVALEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEP5</accession>
    <name>A0A8H5FEP5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEP5"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="51278" checksum="2D623F9C22FF9930" modified="2022-01-19" version="1">MDGGVMDGDFNWNGAWPVELTTASQGSSDTSLSSALTDLLGLSGPTSAPDATNIIPHLSTFLGGFLGGSSDDTNSPNSNVASKQTTDVTQQTQAKTLASALSKFIGSTDGDLLHVKGLGLTGGFPSKRWFASSPSESDNESTNWFSFPFQRKRDVERDEGQGNEKIYMASVSPWSLPTLFLYTADQHLYAKRWEALVNSSFPTNSNSPSNPLNIDIIQIISWNDYGESHYISPIKGAQPTGREAWTGGMGHAAWLPLTSYYASAFKNGDPVEDTVWVITLLAEPANVTFEVYAYTPSSSSSSSSNATTTADADVDNKIISSQTISVPAGLSRLAMPIGFPDAGGDGGIQSLSVRARVVRSGSASGSGSSSESQDTTDTLVMQLDAGNPNHSSNAGDSDSNTNAGNGDAQGQGDGTGNGDGDAQTLAPFVFVKNPGKYNYNAWVGCVSSSGRGVDFGFMVLWGGGTKSAHALLVERAFFMSLMTVMTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FG89</accession>
    <name>A0A8H5FG89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000243">
        <property type="protein sequence ID" value="KAF5335427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FG89"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="13999" checksum="104426F31F31D3A7" modified="2022-01-19" version="1">MLAGDVLSLGEVWEYKESPDQKSGTENVLKVGRLRLGGNKQLSYKKRTWSSGALGQDWWIETTPNGWTRCWCKNSQSALSFTFSYRVAINDYAAAWLAQANHLVSCMGLTASQGTSFCWDSEFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJA5</accession>
    <name>A0A8H5FJA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJA5"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="672"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="816" mass="90075" checksum="171304B961F067E2" modified="2022-01-19" version="1">MLNNLGNAFESRFEHLGELGDIENAIHFASSRELGDIENTIHLKHQAVDLTPDGHADRATMLNGLGIAFARRFEHLRELADIENAIRFKRQAVDLTPDGHANKASWLSSLGVAFFCRFEHIGELGDIENAIRFKRQAIDLTPDGHADKASWLSNLGNAFESRFGCLRELGDIENAIRFSCQAVNLTPDGHAHKATRFNNLGNAFSRRYQHLGVLRDIENTIHLRRQAVDLTPDGHANKAGMLNNLGNAFKSRFEHLGDQSDIKNAISTFQQSTKNAFSPPSIRYNAASHWATLSSTYQNPFLALDAYKVVLEIIPQLIWLGQTVNQRYEELPKIGWTINAAVATAISAGNLTQAVEWLEEGRGIVWGQILQLRSPLDDLHHQYPVLAMDLERVSRALQNAGTSTCSNAIDNPNMQGAMTGEQEAQQHTRWAAKYEELIAKVRKLDGFDSFLKPKKLSAVTPAAMNGPVIIVNIDQSRCDALVVSSSHDIIHVALPNFSSKLAEELHSGLIASLQASGVRVNRDEERYSIPYPAREQGCNCLKSILARLWSTVVQPILSEIEDVLHHSTEFCLPHITWCATGALALLPLHAAGIYGSKDPSDDIKLSDFVVSSYTTTLSAMLSSGHSKTQRDPRKKPKVLIVSQPATPNLKPLPGTKKEARIIQTYTSPKHSCHLTHDEAVTRKNPLNSAFALYDGELKLQDLMCLSLENAELAFLSACQTAAGDENLPEEAVHLAAGMLAVGYPSVIATMWSIGDKDAPIVADKVYESLLGRSDELVTWNMSQSAAYALHAAVEHLRKEVGEMEFVKWVPFVHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKI4</accession>
    <name>A0A8H5FKI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKI4"/>
    <dbReference type="OrthoDB" id="3041043at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="233" mass="26944" checksum="7C74BD73764C8F09" modified="2022-01-19" version="1">MFSFPRELQNLVLREFSSVDRHRFSLVNKKARELVLGHNERSFRIRQFLLRFFGALANVARFRILQYELGLLVSGSTALQFFFDDLDTYVELIKFRPYADFLLEIGYVFDPIQGQPKDFEDALAAALNAERPHADQDDDFAWEGYRGNGMAEVFNFQKSDKKVQVITCVQTPIEVILNFHSTCVMNVISHSHGYSLFPRATFEDRVSLHTPTFATVKDKHKHARENMPDMDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPT0</accession>
    <name>A0A8H5FPT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPT0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="86" mass="9721" checksum="13B08663C2279750" modified="2022-01-19" version="1">MLEICKYIYRTEKLSPPLQPSVLRTRRCGLLVEPSIGTFGLELSGAGTLLGFMSMQWKLMVSLRLVKSLEGEVSWGTMSIRRFPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQB9</accession>
    <name>A0A8H5FQB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQB9"/>
    <dbReference type="OrthoDB" id="3353982at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="75032" checksum="D29069480C1088E1" modified="2022-01-19" version="1">MLQDLPTELYEAILSHVPESELPQTTLSLTRVFPYHGISTRALFRDVRLKDAEQVLQLYRRLRKQSADNQEEDPAPTWVRTFNLETWTADAEIVLNLVQLLPNLTRLVLWIGLLVLWIGPTNFMPEHLEEMFDLRRKSQGSRCLSCVGKLEYLSFRFRPYVRQASYYHFLKGAYFDSALEAISCWPSTNLPKLSIIQDPLTTESSTSAGSDVQVAPPSVSFSSGLPKLNHDFAQPLVFFRLDTTVPELLRSDAIRLSLTSFRIRLPARSLMRSLTHAPPPNPPSFGAPVTPGEAPTYRYSVPPRNSHLPPSPYLKLLDLSTSSVSEDAIALILVRYPALTHLIADDCGILKGELGHRDGGQEWAKLSKECALAGSLRAKNREKKVKQWIEEEKTAAMNKQDATGSRGREHSQAGEGESSAAGRRRPKKGRKGLATATISLKKNDAQNHNGANTISRPRADPALFIQKIRILPPTPTLQAFSTSLVVPAGSIPAEAADILSSTNDLWERGWAEGIKILTAIRNRLRASWRTGSVRVLRFATVEEMQSGVGSASSYESDSSRPQTPDGNGGSSRSPARSISSLSSHLSGKSEMNYGEEGLGGLVDVVDESEFDVNLIGTPAGNAPVLCLAGSSEVYNPVVVRAQASSLAGSVHAGRSRPGDNLRVVRPHAEGCPHELGKDTWLDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQE5</accession>
    <name>A0A8H5FQE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQE5"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5345326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="621" mass="69452" checksum="C024559926663736" modified="2022-01-19" version="1">MASSMKDNYGATDRSELGNHDVDAEANVLRNPAPLQTQLHRGLSARQVQMIAIAGTIGTGLFLGTGKSLATGGPASILICYAIIGFIVYVTLLLLGEMATQYPVAGSFNAYATRFFSPSYGFALSWNYWFNDAVSVASDLTAAQLVMNFWSVEHAWIVSLVFWLFLVAINAIHVKAYGELEYWLSTLKVATIVVFIILGILVNVGVNQQHEYIGARYWHIPGAPFVDGFRGFASVFVTASFAYGGTESLGITAGETKNPSKNMPRVVRFVFWRILLFYLLSILLIGLNVPWDYPNLSNRSSTTSPFTLVFEAAGSTVAASFMNSVILTSVLSAGNHALFAGTRVLYGLSTTTPRQAPAIFSRTTSRGVPLFALLATSSISGLCFGSSFIGSGALWGWLQNIVGVSNQIAWFSIGLASWRFRKAWIAQGRSLDELKFRAAWTWPWGPYFVVISVAFLILVQGWASIIPTFTAVDFVSFYVEIPIMIVMYFTWLLIRRPIPQSKLDEQEQESNDRDRDEEDNGNEGFSGALCYRETTVLTPLLDVQDVGDENRARARARRKRTRLWSWWYTDMVDIHTVDLKKDEYEEDSTGQDQRDDEVRQRRLKGSPLWSKILWRLYYWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQH2</accession>
    <name>A0A8H5FQH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQH2"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="215" mass="24461" checksum="6067BF0B8C38E55B" modified="2022-01-19" version="1">MADPVAAKSSFLCMYMSSHPDTLVAYAKWFGKVEEPIQSADMTGIDTKGMNLRCTLKSGQKKEVRVPIEPPLKSYDDVKPRLLEMKAIAQEGLGMIKTPVLSELHIPLSSLEVVLLLSVICYLVFFPQDSGHPIWGPAKWWYEIAGEKTKYALIFFGVCHVFEMMYVTYLSYIYKTGFVNGVIYVFMTLLSGYHIWRDIRKRAQAARINSVMKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRL6</accession>
    <name>A0A8H5FRL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRL6"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="818" mass="91736" checksum="BA3D2DC48C058DB4" modified="2022-01-19" version="1">MPNNICSSCLNLSVPCTHNKGQQKRGPKPGTIRAIPSQPVHILVANILKGTPSEPFSIPEDKEAIRKILVKLASRIQELEKDQKFAAYDNWIEGLRDEFTSSNATSPPSVQDANTPETLPPADDSEAVDNLSKELAQFSFGAPSETHFGESSNIMLMKVALDHRKELSGSDLPDWNSVFAHVRRPEFWETDRSWYPIAPPQPKASVYTFPPTDDLHRFIDIYFLERESYFPLLHRPTFENSIRQGLHHRDPAFGAVVLAVCAHGDKLYSTSSLGDNPGDRWIDQIRLDGFVFHETLALDHLHIYCLMISYFHSVSKGINTVWLVAGIAIRRAQEKGAHRRYFATSAQPTVEGELWKRAFWYLMIIDMMMSTFFGRPRAISSQDFDVDPLIECDDEYWEPEDGSQPFVQPAGKPSKISYWNAYLRLMEIYGFALLTIYSVRKSELGNKMGIGNIEWYEKAVMGIDSALNQWLGSMPEHLLWEKQNPDPIFFTQSTLLYSWYYWIQISVHRRFIPRPKDSSGILSFPSLAICTNAARSCLRVCETYVKRESRYHPQLTIVIFNSATVLALNLIRSTKLNIKFDARKEMMDIHKCIELLRLYETTSRHAGRLIDVLNVMMFASYLPPQSENAVGSSAASCVGSSAASTTAQHPPQAQAFQPQPSAPNQPLHQFTSTNGDWGNATSTALPPSAFTTSLSTSNTTTLPFYSSELGGLPIHPSFNSFNNEPIGEFSGFSYPQALANVALSPDVRQYSSLFDDETGNNSGTGQNSSFMTTSPDPVPDTSQQNYSSVSQDWDAFMASVDQLLGKSDETTSFDPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRQ6</accession>
    <name>A0A8H5FRQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRQ6"/>
    <dbReference type="OrthoDB" id="621413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88742" checksum="1A0292E13F3B9C8F" modified="2022-01-19" version="1">MEPMDTGPGQTSPRNQGNFFSGAQHMGFAGSTITNVAGDANYNYITNFPENKPNEITEDDLLLRRPQVPDVFTGRSHLVKEAVNILCGTKQIHIAILGAGGIGKTSVALHIMEDPLIKEKFGERCYFIPCEMLPDAKILIQGLVLTIGLQVTQGKDSLKLLLDYLRGGQQFLLVLDNFETPWGSKGQTEVKNLIEMSCRCNAVSVIVTMRGTEGPGQIKWHKLGGGSGLPALELGPAKEAFCSFCSDGDLTIEEDPILENLLIQMDGMPLAIMLMAQLAREWPLKNIMERWNHQKTAVLKKFGLGEQENRLTSIEVSIKLTLNIVREKLSPTGEDVLRLIALLPSGIPDWLENLPKMLPDATMHLDDTTTQALILKKACLIYETGDKTLKILTPIGEYIMKSFQERDNVENQVWVFYESFIDNLPQNPSEEDSQLGLHIGNIYKILEIQIKRSFERSHINVLQQLYNYSEYFSGLVPLIAKYLRWKSHLNLSDQAEVMFMQEYMFSFMGEYGKAIDIIHDVEELYKDQINQETSDVEVVTRNNTIEQIQAECYRRLGESFYHQGRYTQSKQKVQQAQDLYEKIGDMRGVSRSLQSLGNICRMLDEYEDGKIMLERAKEQFEGVGDKLGAAQCLQSLGNICRVLSQYEDAKVMLEQAKEQFEGVGDRLRAAQSLQSLGNICGMLSQYQDAKVLVEEAKEQFERVGSRLGAAQCLKSLGDICILLDQYEDAKVMLEEAKEQFEGVGDRLGAAQSLQSLGDIFSMLSQYEDAKVMFEQAKEQFEGVGDRLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV37</accession>
    <name>A0A8H5FV37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV37"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="328"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5350246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="705" mass="78636" checksum="5A32E664AD943B7A" modified="2022-01-19" version="1">MTRASLPQACFMDSFDDLLGQSRSILEENPFSDPFSKRSSSPDPWSTPFSQPRDDIYSSPFASSSTDHESASVSDTVSTSTETEQQADTTHTSTEPEPEPSPSDPLDSAAANQPDDDEDNEPLSKRQSTITRSPGFRESVSTTSFSEIATIRPAVSEEQESAVSTSLPKSSTPTPPPAPKLQIQPTTTTTPAVADEDKPKPSPSWKEVESEDPVPPPSISPSHSSPRPSQESTLLNHESPFTAQGPLTQSQAIDRSLSSLSLNGDTVDGWQAEQESWSNDQRHPVVSRMPSDEDSDDDKPIGQTVRGLSQSSSLSPKRNASNRADLRPEFVITVDDPQKVGDPIRSFTMYTVHTRTTSPLYQKSAFSVLRRYSDFLWIYETLSMNNPGVVVPPVPEKNTFGRFDDQFVKQRRFALEKCIQKIANHPVLGKDPDLKLFLESDTFSLDIKHRKAEIATERGGLMASIGQSIAGPRFYETDEWFDRQKAYLDSLEAQLRGLVKAIDLVTKQRTELSVCTNEFAQAVSELASSDVGRQLSQSLSGLAEVEKNAHDLQVTQSEQDMVTLMGTIDEYARLINSVRLAFTSRIRMYHVWKNSEADLIKIKQMHEKNRSQARQQMGHSLSQIAEAERRAADAKLEYEHVSKLVKTEVARFEQERIEDFKNSLHAFLEGMISRQKELINSWEMYQQVLLKRSGAEKDGQQPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWB9</accession>
    <name>A0A8H5FWB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWB9"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="417" mass="46192" checksum="3BF6A7F06DD3E2DC" modified="2022-01-19" version="1">MTIPPLSELEELAKTIIYEAKENGLLHKMTNRTVREEIETRLSLESQVLNAPKFKKPLNNAVKACVGAIEEEKERQRGQDADDADNEISPKTNRVSKPKTNVVKEEDEQDVEEKDAEEEEEEAKESSSKKRKGKSETERPSRKRKSGKENGKDASAAGSSKKTSEKAKGKKNTETNFKSAEFVPPSSDVEEDAAMQGDSTAKDQEEDLSSADEGTPKPSSSKTKPPAKPLQVKSEPHASTNGDDSDTGLSDLIDEPPKKKSKGKTATKASGKKNEKPSNKKELSKDEETIKRLKGFINACGVRKPWSKLFDGIEDQPSKQIKMLRKILEDLGIEGRPSMEKAKAIKAKKELENELGKSRRLLAVSKQVTRSSRKAQEAEESDEGNVDEEDVNERPVKRKTNARQSIMAFLADQSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX26</accession>
    <name>A0A8H5FX26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX26"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF83">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="538" mass="58365" checksum="5B220BF222EBFFD2" modified="2022-01-19" version="1">MSLPSLSVSLDNPVDDSHLDSVLAKLGHTLKAEERADYLALLKAFHETISAVKDLPDYVPPTDLRRFPRENLHFPKAEENDLGAWAWKFTAKDTQPNEGILVGKTIVMKDNISVAQVHCLLGTDAVTDFIPTSDATVVTRSLMAGATIVGKAVCENFSMTGTSFSAATGPVHNPYARGYSAGGSSSGCGALVASGAVDILNRGVGGDQGGSIRLPASWCGIYGMKPTQGLVPYTGIASLESTLDHTGPMTRTALDNAILLKALAGNDNIDDRCRATPPPSQIPNYPSVLDEVKKSTKPLQGFKIGLLKEGFHDMPSGLNDPRVAMKVREAAEKFKDLGAVVEEVSVPQHSMSMPLWLCVVRMGCVPGFMGGKVGRQGFYDELLTIKMGNLHTAEGWEKTPWAAKNMIMNGVYMQSYCPELYGKATNLIRRLREQYDEALSKYDVLVMPTVPYLPTPHAPLNATVVQKIEKGLGQTANTCSFDVTGHPALTMPIGMLEAREDKNIKFPVGLQIVGKHFDESTIYKAAFAWEDRFSWKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYP5</accession>
    <name>A0A8H5FYP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYP5"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5353849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="826" mass="93521" checksum="C6FE234F6E0C84B7" modified="2022-01-19" version="1">MSEQQDFRKRFQNACDECRRRKVRCDSAMMTNNVCSSCVHLNVECIHSKPQQKRGAKRGSIRKAPSHSAQVLVDAILQATADEPFDIPDDKEVVLKILKKLANRVKTLERELGKCHRKLNHTSNHSLPAEYGLSAETSEREEPYASSPTGSDEVENDLSTALAYLTIPDTPKQEHFGESSSVMIFLGTLDHRQELASSFESWRVMYSRIRRQPFWENPSWIVRPVSSFPAFEFPDQKTLRALVDVYFTEINLYDPLLHQPSFEQSFENGLHLRNAAFGALVLIICARASLYTNRQYPRGDPQSCGWVWYNQIPFDKFVFNEPLSLYHLQLYCLTIKYLREIEIALQPDTVWLLVGLAIRLAQGRGIHRRRNQKPGPSIEGELWKRAFWYLTTIDTNLTEYYGRPRATSIQDFDLDPIIECDDEYWLSEVPSQRFKQPVEKPSKVSFWACYLKLMQINAIAHESIYSIKKPGFGVNVLPPHEVVTKLDSALNSWVDSVPAHRKVRWDSPQQTDIFFTQSALLWSTYYSVQIQVHRRFIPQTGYSGESRFPSLSICVNAARLCIGVVEAHLRRRSLTAGYHLVLNLFYPAMILAIHLWHGISTKSFRAQIVQKEIACIHNCIDLLQSYEPRVLLAGRFIDLLNTVMSASHLAPYLPLDGASSESSTSAFQAAHPHPQPASASTLPWSNFGSPGFEIPLYTSDLSVYDSTFSTSSSSYLPSTGGFIDASSMSLSDVALGPQQFAQSENLNAAPGYGQGPIAENMVHYATDEHGYTIPPQSLANADLPQWPGNPSEQDWQEFMMNVHQLFGVPHDPSFGSQTEDYNIFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZE7</accession>
    <name>A0A8H5FZE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High affinity methionine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZE7"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5354599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59227" checksum="3E4FBF1FC09A7374" modified="2022-01-19" version="1">MSAPASKSSFDQYKDPHDHDHDQEPEVIVKPSSASDNDGESFDNVPRENRRIGTLSATMLIANRMIGTGIFATPASILGGVGSIGLALFMWVIGGTIAAAGLAVYLEWATALPRSGGEKNYLEYSFQKPLYLITCIYAIYAALLGWPSGNSVYTGEMLLNAAGTEVNRWNQRGIGVAVVTFALIIHGVLPKWGLRLQNILGIFKIVVLLFIICTGFAALAGHVPGGRPHNFTNAFAGTKTDANSFINAMYNVIWSFIGYSNAFYAMSEIQNPIRIVKRAAPLAMILVTVLYLLTNVAFFAAVPKETILSSERLLAAEFFGIMFGKRANQAISVLIALSAIGNVLAVLFSQGRINQELGREGVLPWSKFWASNKPFNSPLAGLGLQWAVSLIIILAPPGGDAYNFLLNLISYPLNIFNTLISFGLIIIYLQQYLARRDGSTWDLPTWAPPVRATLPVTVFFFLANIFLVIVPLVPPAAGNEPYEDIPYYLHAVVSFGLLALGGVYWVIWARVLPRIGKYELVRVVEVGSDGLSRNVFRKRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G057</accession>
    <name>A0A8H5G057_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G057"/>
    <dbReference type="OrthoDB" id="5289249at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="254" mass="28131" checksum="6E83D6CC5087629D" modified="2022-01-19" version="1">MIVPPSLEIDTKTISKIDSAGLDTPPPPYVSLSHQIPSSSKPSNFVTISRRAHNIKGSFNIDPSLRVPISYLPALAEGEKEKDRQNLRLESKNLNVQAEVYVLSRQPLDGRQKVTLTFSSSNGSVTCRVRRGEGSDPPIVINATSRNGSVVAHIPRSFHGLITATTRHGARPKLSESVMTQTTTFGNDGDVSRYYVGEYDAEHLEKNIGDELVVESRLGGVRIFYDEEEETNYLTDMIQSARRFAAFGEQLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1S7</accession>
    <name>A0A8H5G1S7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1S7"/>
    <dbReference type="OrthoDB" id="3118741at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="440" mass="46463" checksum="703331E868BC075E" modified="2022-01-19" version="1">MKINAEPTDTIRVVKTKIKESPPPLGFAVDSQKIISSGKQQHNNGHSTVPSNALAMPTSPTNTETISSAEPGHSILVNQDNSPPTVPPNAHTLSMPRPTTNTATISSAEAGTSNSDVLIPSSVRPSSQSLAFNHAQTTPQTAPIVGVGSDGDQKVLATLEGSQVDDLEALKDLGFSEQATFEAYLLCDGNKERAASFLAENGNDSSSSSSSVFADNFKELIASLGEPDFDQIQQLEALRFPHDVALAAYLACNKNAQLAASVLVEHGADLNFGSGDEPASAISNTPLALPSTSNPEASPSSVPETLGFSATPSQRSLGKRPERPWSPDADDSASMKTKTSENSATPSSSVPSSPPTSLFAEVSPASEPMIIDDSEVEGKATINKAIRENGISSRGCDHSQFPTREGHRRSCSRITTSNPTVNLELNDHHRHSYLLQVPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3H2</accession>
    <name>A0A8H5G3H2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3H2"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5357694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="309" mass="35500" checksum="47D46446D598550F" modified="2022-01-19" version="1">MPKKLSTSPRPDSHEIYEGEAESESSGSHDNLVNEDPNPAEQEAGEEDSEEEKDKNGDDELVQGMDPAGFSAPAEKIVKPLTPEALAAFKAAQERTGVVYISRIPPGMRPSKVRHLMSQCGEIGRVYLQQEDPKRAYLRRKYTATKKVHFTEGWVEFKDKKIARSVAEMLNAQPIGGKKGSRWHDDVWTMKYLPKFKWNMLTEQIGKCFGCVYAIYGILMRFTAHEAAIHTAKLRVELSQSRQEQRDYLKNVELARVLEKRAERKREKGEEMELKPLPQPKKRRREDNEEEKKKKPRNEELDSVLSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8D5</accession>
    <name>A0A8H5G8D5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8D5"/>
    <dbReference type="OrthoDB" id="3025387at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034164274" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="77" mass="8124" checksum="F1013A47E570CF98" modified="2022-01-19" version="1">MKFSLAISTLAIAGLATAVAIEKRETVGAGDVTSLASTGQLVTATQVFPSIIDVEPFMVTVTREHVWTQFPTNTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA79</accession>
    <name>A0A8H5GA79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA79"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17586" checksum="8672534C49FEDEA3" modified="2022-01-19" version="1">MKGTDISSYNSVFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWDDFEEYKERAVGPHLEWLKERERQEHWKTTPTSKSGSGPSQGRTVASVNALMNMGPGANSSFTPLPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDT7</accession>
    <name>A0A8H5GDT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDT7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="13324" checksum="DC0A84F898A7C486" modified="2022-01-19" version="1">MMCLKLRQASSHIPFILVLAFSQDVRCGYQTFRSSERIRRALGPSVTKYVIDPSDFRHRFENGLYDNLMEDEAAILYKRIQNHDVQMGNLPLRLWTTVAESCALILETKRRGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHM9</accession>
    <name>A0A8H5GHM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHM9"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="352" mass="40901" checksum="15862EE7DC475231" modified="2022-01-19" version="1">MDLRAAVPKHLFKRSTTKSLFYILQHLVITMGTKINDFVEFVMERIVSFLGSGELAEVFVGKVVSTVMWLLYWGWQGMAFAGIWCLGHEAGHDGLSEYRWFNHLSGILLHTFVLTPFYSWRTTHRSHHKATNNMERDETYMPPTRKDFKLPDGKIAVKMDYQEVLEETPGFTLFKLFVRQFFHNRKGNRRYPPYTSVSTRYIPPVFRISGLEVVVRPLPPLISALQTRRKKKYYHVEYSDYQYVGSSGFIRKTQWKEGIRGALFNALAVPTQLKEWTFSRGALATVDRPLFGWVGRVLLHNISTDHVAHHFFASVPFYNLPEVTEAIKPVLGEYYNYDSTITGFDPLEYLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIL8</accession>
    <name>A0A8H5GIL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIL8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="79"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="287" mass="30662" checksum="82E03A545D95D8F1" modified="2022-01-19" version="1">MTIVGPPINLVQGQGQGVSISLMQRQRPTQLSEEDWSAWAKFNTEGLRSKYTTSGSAPVKKKRASGTNAIVNQGADSSFFGTITIGNPPVPYNVILDTGSSDLWITGSGCTTCGSTPTLSLSSKSRRQFRHQSTQSNPASSLKNLNQPFSITYGSGAASGTLVSDSVAMAGFSVVDQVFAVCDDVSDGLLNDPVSGSMGLTWQSISSSGATQTLAGAKDAVWDEPLMAFQLTRFNQDPKARQEEVGGSFTLKIVALTITHTFFIPALSQHVLYHFLRFLFNVLAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ37</accession>
    <name>A0A8H5GJ37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">D9758_003341</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ37"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="145"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF5365714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="940" mass="100712" checksum="7623D1E34F5B3B29" modified="2022-01-19" version="1">MATKIDGTAIAQDIRNSVAERVRAKRAVFPRFQPQLVIIQAGDRPDSCAYVRMKAKAAEEVGIKFRHVSLPAEATVEEVIQVVNSLNHDEQVSGILVQLPLGEHVTPEGERQVTEAVIPEKDVDGFHAYNIGHLSSRASVPLFAPCTPSAVIRLLQSTGKPIEGTNAVILGRSDIVGSPVASMLRNRDATITQCHSRTKNIESIIKNADIVVAAIGKAEYVKGSWIKPGAVVIDVGINYIPDASKKSGQRLVGDVEYESAAQVASHITPVPGGVGPMTVAMLMENTFISAEKLWEKARARTLKPLNLNILEKVPSDIEISMAQTPKPITQLAHEIGLLPAELESYGKYKAKVELSVLNRLEHRTDGKYVVISGITPTPLGEGKSTTTIGLAQALGAELGRPAFACIRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAVTAANNLLAAALDARIFHEATQSDKALYNRLVPSKKGKREFAPLMLKRLKKLGIDKTNPDDLTPEEINRFARLDVDVDTITWNRVIDTNDRYLRKITIGQAPTEQGHVRETGFDIAVASECMAVLALTTSLEDMKERLGAMVVATGKRGDPITADDIGVSGALAVLLKDAIKPNLMQTLQGTPVFVHAGPFANIAHGNSSILADRVALKLAGTEEGDSSDRVGYVLTEGGFGADMGMEKFCNIKCRVSGLKPDATVIVATTRALKMHGGGPDVTPGKALHETYTKEDLVTLKEGCKNLVQHIKNSRKFGIKVVVAINQFATDTPAELALVRDEALAGGADAAVVSNHWAEGGAGARALAEALIATCEGPSGFKFLYDLNLPIEEKISIISKEIYGADGIQLSELAQKQVETYTRQGYGNLPICMAKTQYSFSHDPKLKGVPSGFTIPIRAVRISAGAGFLYPILGDMQTMPGLGTRPGFWEVSLEPETGKVVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ58</accession>
    <name>A0A8H5GJ58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ58"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="33880" checksum="2B73F02C3C4E0BE9" modified="2022-01-19" version="1">MSSASAMNKNNSAVKRIMQEARELANDPSTDYTAAPLEDDIFEWHCTLRGTPGTEFEGGLYHTRILLPAEYPFRPPSVMLLTPNGRFELNTKARSTKIYGNLVRLFLLVYDMKLKLDVWVAWGIRTAIVGLQSFFPLKGQAAVGVGGIEYPVSERKRLAALSRDWTCPHCQQSNLELLPDPPSSSSTAVEPETREPQTTETMDVPSADTTSTFPTVPLEEPAGPLIEPQLELGPAISVVQADSSAESSDSSSPQAREDPTTHADPSSVIPESAPLSVQTRTQTPAHASPWILDAVIGLILSLVAALIYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJN4</accession>
    <name>A0A8H5GJN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJN4"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034620899" evidence="3">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="327" mass="35352" checksum="628A7990F920C8D5" modified="2022-01-19" version="1">MSSLRILPLLCLFLLYSSFCWAALMNSTVDDTSPDSRGAKIRFFPPDAWNFGSGCKNSPCWVQLDTNQLYQGTWHESIFSAGERVNGHANQVLNVTLGFSGTALYVYCVLARTTTRPAGNSDMTFYIDGQFVGALQKPAPGTSGYDYDVPVYVNTTLSHGFHTFVLQNGHPGNPNSLVILDRIVYSYDNESSTTTSSDPVNTSSAGSSQNSSSTNIAVIVGPAVAIPLAAILLGFIYYMRRRRRQRSFIPETAEVSLVTPYMLSQSSSGNTTPSPSPSPGNSSRSKLAHNPLAQASPLPTPLIPPIPPPTYSETFAGPQTSHCHHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJP9</accession>
    <name>A0A8H5GJP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_005768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="1588"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="1659"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="1828"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1789"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="881"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="937"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1260"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5366228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1857" mass="200068" checksum="05A852134568931D" modified="2022-01-19" version="1">MPHVSTGGRTKVSHFIEHATDTSSGNEDEEEETARTMERKRKAQAKRSPNKRQRLGDNVPENSHPTAGKSYADTGPPSTINPSIRPSANRTVTSNIAQSSQASMPSGVSTPNGQGSDRIWLSARKSTSGKRPTQPSGMAARKSAGDKPPPPLSTHNAHESATDIDVDDAQNAASSSRGAASSSIEQPRPSTSSGINKNKGEATKFSKPQTVRKSTGKLPPPRPMRSSVSASRSDSTIGQTSSSRIVQTARKTTGGRPSSTQMPPSTASSPEPPSQSRSKPGPGYRKSTGGPSMNQRFTAADKERRSTFGGVSDLLKSKGKEKAVEEPISAGTTKRTKRTRAEKQRRKQTADSDSDDIVVLDGPSNVRPRSISAPGGSSNPRNTQGQTSPSKTKKPPNPPPLHVIDIPSSNEGTPPVSNITRSDRSDSISASFGHFPPPQSQSRRINSKPTNDDEVINLCSDNEEPDIPASLSSPLRSQRSTADSINAPVAPAVGSQAKANTGTDVIVISDDSDEPSVSNRAKGKGKQKDEPSKSISTSQPRPGQRLSRRLDSDGSRPPSRASGDYTVPRPSGMAYESLDKDYEMPRIAGSGISFGDVEGLIDSVVVQNGNEKSGEKASERNEDEEAHLPQSPPVPEEPISLCELKLFSCLRGTRFGDHDYFLVANDAVSQQDHQPDNDIVMDPPQMDRSNYIMDEADSSGIEPEPDPVIVEDSDQDRAVSADMILEANISPDATKEVQEIGPDGSGDLPAEMAGESCVDEPPAVLEEGEISLDLAGTDPPTDLEEGEISLNLTAPGPEPSLRSEESDATGPGPEPSTHTISKSEPLPAEVQAQTVPESHVDKPIAFDGEQGPEQPTLTAPCPRSPNTVPEPVSRPIPESSMTHDADTVMEEPVKEIAKAKHSSSRSTPLSYEESMAQVYASMSRGNSPPRSRKSAPRTKPSSISTSASSISASVPPSRSSSISTARKSSGSSIIPQPSRVSSHRTPSLSLSTSLANQNRHDSSQPSPSRRHTGDSMGIPAALSTSSISRPSSSLSNPDQDREGKSARSTSVTSSSLTQKISIPPVSGSRENQGRSSQNTLSNPIIPRPASSQPNALVNVYNAMNQAQSTDVESRISFERYKEALRSRAKNVENKSRFEDESAPFFMRRDWKKPLEDAVQDVMNDLASTTEKISLAPESSTTSSSSVKTVGGDDAVSEQSTSALVQQQPMQAEVQTQRAPLPVDQPPVPTSTELGDANVTQSEASADADRDIPMQTEETNDSTAATGLTSPNNQEAPIDTTSWLNYDLEYADSPSPIPMNEDDDTSAELMYPEEESGHPAADPLPYAPVVNGVVSKQAEHAESVVVETNGITQPGTSEGYPEPFSSEPIAQSSSPVLQSGIVPHEPSNDELFLPEPISQSSSDIGPPQVPVTEEEPTGRPIRSRASSSDETIIAPDDCIAVRRSRRRSRGQSTDSTPLNRTPNDTPPRSSSPDDAAIPKTYGGLPVMTWENFRHNLRNSVPEHHLARNLPHMLQDHINAMSEVVRNYPMMRDIFEIMVAEANAEDEPGAPPVTLFNTVDNEPAPPWEFHYTNKMWLGDNVPLPSFKNLKSCNCVGRCDPESKTCACLKRQVELTETYHTGFMYENDGILKQTGLPVLECNSLCGCDEDCVNRVVQNGRKYEVKIGKTVDKGWGAFNGSKEIPRGTFIGIYSGELLADADPEERGKKYNFFGRTYLFDIDFWYIKEKVPGREDSKYTVDAYHAGNFTRFLNHSCDPNAALTPVYIDEDDWERPLLTIFAKKNILPDEEITFSYHGDPDNEETPASSPVKGRGRRKAKGATASTKLKDDAVYTDCRCGSARCKGIMFGVSVNAGEDEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKL6</accession>
    <name>A0A8H5GKL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKL6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="566" mass="63912" checksum="F26686C10EB7F3BB" modified="2022-01-19" version="1">MESSSIGLFADGSTLPSPSSAFTDFNDEQISSRADYVALVNVVSASATCVDTDNQSDAEGKSVVSNEDVQNVTAPTPDRLDQSLASLTPVDTDTGESDVRRESVVSDEDGKADDEGDGGYWKHSANGKQVDVLGESLSFDESNSEVEDQSRNGQPPSPEDPGSEVEETAIFNESGDEELDFNRGFDGLSITMDGILLPLQRLRYIFTVETLHSWSTVRLKLDVDLENKDRNFFGEFLESTIVDVRAQCPILLIGVWSLFYFKNLTSLRLDNVFFDYEGEYNNYVLDILKKCTNLIEGYFVVPRTSRIFREARREVHCPKLQYLTLGFVEEASNYSAIHILPHLKCPRLIFLHILHDFGSSEMDDEEYCPVPDILTKFFITSRYPPVQCVRFEKVPWLDQMDLYQCLADRSASLTAVDIRYCPHIHLGWISRAFNYKRAVHDFVPYLRELALASYYVYSHEVKRQLNRMIKSRRVVLNPEDDDPYHLEYLKKVLLLELHFYEADVNGRTEGEEEWVDELKFGIRVDEAGSGEAGEKELSSGLLLDEAGAGEQDGDGDCNEAVRRGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKQ8</accession>
    <name>A0A8H5GKQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKQ8"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0967">Endosome</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="20143" checksum="9161C03972386FFF" modified="2022-01-19" version="1">MGSMCWAKHPSGTSLTPSSEPEFNRSGISGILRTVEASAQGRDPNMSDAFQALEALMIKAKDMVKLAADLNERLTVTSTTSTASGVGTEEATFIRSSLSQLGLPMTNAPVTLDMIKDERKWFEELAKELAGVLQGQGQGHGDKNQKTTEGDMMKERGVIALDEVWGGWNRARGVGKVAVCAFYAASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL45</accession>
    <name>A0A8H5GL45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL45"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33036" checksum="A14EFE11E1269C2E" modified="2022-01-19" version="1">MSAPPLGYYVPAVLFFQDNEEIDVDAYKAHILRLANGGVTGILVQGSNGEAQHLSHDERKQAIKLARDTLDEHGFQNVLVIAGTGAQSTRETKKLCTDAKEAGASHVLVLTPSTWAPQMSVENILRFHREAADASPLPYMIYNFPVVTAGIDLDSDTIAALAEHPNIVGTKLSCGNIGKLHRLTSRFSPSEFAVFAGKSEFFAHGLLSGSAGTIAALVNVVPKVHGHLYKLYLEGKIKEAMDLQGKLGHADWGAQKIGGVGGVKAIVSKNFGYGGTTVRGPLKAVSTDSLQNNKYYAALEEVIALEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNH1</accession>
    <name>A0A8H5GNH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_002421</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNH1"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="175"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5368343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="368" mass="40357" checksum="652FFD2A123C6EC1" modified="2022-01-19" version="1">MSKPTLWLRCEKKEFEKRAALTPTTSKKLIDAGFEIIVERDEQRIFDDAEYEVVGCKLVDNNSWPSAPTDIPIIGLKELPVSTDPLPHTHIQFAHCYKKQAGWSSVLSRFHRGGGTLYDLEFLEDANGRRVAAFGFHAGFAGAAAGALAFAAHRKGEKLGMLEPYINEEAMIADVKKALGGSGKGVKALVIGALGRCGRGAVDLFRKIGLEENDILKWDLDETAKGGPFQEILDVDIFVNCIYLSSQIPAFLTQEQIIKAGKNRGLSVVVDVSCDTTNPFNPIPIYSINTTFSEPTVPVDLPSDLASLSVVSIDHLPTLLPREASEQFSSDLLPSLLEFPNRQKARVWTDAEKLYKKKLAEAVEAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQQ2</accession>
    <name>A0A8H5GQQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQQ2"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="231" mass="26003" checksum="472F45C5B40C3946" modified="2022-01-19" version="1">MSCPDCFKGVVLDGEPTGSIDSSTRAYLAPGPEGNTSRAVLLFTDILGLGLKNPRILADNLAKRLECDVWVPDFFLGKPPVPPGYMKMPERPGQKISKLRFIWSILPHLPGLIRQRPSVVDLRFIKKLKSEKKYTRLGAVGYCFGGSMCVPCSWACAEEDFTFSPEVRANAEKCLKAREEKDNFVDYEFKEYKGTVHGFAARPNLEIPEVKEGFEQAFEQTVNWFDKTMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRH8</accession>
    <name>A0A8H5GRH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRH8"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="44804" checksum="AF43CFC0C419D48A" modified="2022-01-19" version="1">MSTYGHLFRVTTYGESHCSSVGAIIDGCPPGLQLTPDDIQAQLNRRRPGQSNLTTPRNEKDRVILQSGLEHDVTLGTPIALLVKNEDQRPHDYSETDLYPRPSHADYTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLKQAYGIEVIAFVSSVGKVHIPFSVQRPAQDDEDDGKAEDALSEEFRQLLATITREQVDQHPTRCPHLETAEKMTQRIIRAKDNSDSIGGTVTCVIRNVPSGLGEPVFDKFEATLGHAMLSIPATKAFEIGSGFRGTEVPGSKHNDPFVLKTDGSGRLGTTTNWSGGVQGGITNGEDIYFRIGFKSPATISQAQATAQYDGTPGSLAARGRHDPCVVPRAVPIVEAMASIVVMDQLLIQNARKTAAALLPPITTLPKTMVMPGKVQNKEQNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTW2</accession>
    <name>A0A8H5GTW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF431-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTW2"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22645" checksum="46014F4ACAEF532C" modified="2022-01-19" version="1">MGRARVRGRVQLGRQPRSTSNLMLSLSFTMLPEFHLDAIQHMRTLAGQGSHVHFTHLSSSSSEPLKAKFANIPEGENLSEASCHQEGVLDLIKEHLGGSLEKVCLLDPKAEKELSPEDGDGRFQWFLFGGILGDDPPRDRTAELRILGFPGRRLGPVQMTTDTALGVTKRVVQDKIPLDKIPYIDFPTITFNGKVRLLLSLSACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVS7</accession>
    <name>A0A8H5GVS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVS7"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="38668" checksum="EF14A8D1265BB189" modified="2022-01-19" version="1">MIPQDSSSTPQFSPPSVPSASLPGSPTMSEAFDTRLAHLEQASQSQSEQLAKAEIALHNTPLDLDPPLHLLLLPLITLLELHMLRHPHLASLMVNKLMAKSGGPVQSFMLALFVLKTMAPRSCHAATYHQSLIDHGHLYGSSHFDTWREFEFMPKDEHTQASLTLEGVSYFQGTASVDEYIDNFCALITMAGLNVEPVLYSTNPTEPTIKARLEDAKHPALEKKVAEAEAHSQEWDIMAWYSLAKSSLPPAAAPVPAPRAPAPAQAPLPQGIPMEVDASRQRFLAHHTCYTCGKTGHFSAACPDRQREHFRIVDMSVDDWQEIAEAYAAFQDFQAAPANEPAQEDFAKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX32</accession>
    <name>A0A8H5GX32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_005122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX32"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034694857" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="8">
        <location>
            <begin position="362"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5372587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="582" mass="61510" checksum="0B815195250D80F2" modified="2022-01-19" version="1">MFLISLLAILVFVQAVIAASRTSPPSGAVVVRVGTSTSGEFSSVQAAVNSLPNDGSARSIFIYPGTYTEKVYITRSGPLTIYGYTTDTSTYTQNQATITYNEGSDTAGSNDASGTLRIHTDNFKMYNVNVKNTRTGVQAGALSQYGSRVGFYGCSFYGYQDTLYANEGTQVYLKGFIEGKTDFIYGRRGLAYFGGNTIAVRGAGYITASGRESDDSGSYVFNANTVIQASDAESGTSGGYYLGRPWSPYAKVIFKNTVLNVTPNKALWSLWNGDSSSVAHTLFADYSTTGPSASGLARASFATVLSASQANSYSISSAVGSDYASWVDTSYLHSQLQLQLARMKAAVITSLVALLVGSASAHTIFQELYINGADQGHNNGIRVTNTNNPVMDVTSNDIICNTGLSSSNTVINIPAGGQVTTEWHHGGNGASPGDGDDPIASSHKGPIITYLAKVSDAKSTGTTGLKWFKIQEEGYDASTSTWAVDKMIANKGKYTFTMPKCIPSGQYLMRHEIIALHGAGTYPGAQFYLGCAQINVTGGGNASPATVSFPGAYKGSDPGITLSIYWPPVTSYTIPGPKVLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXE1</accession>
    <name>A0A8H5GXE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXE1"/>
    <dbReference type="OrthoDB" id="3106532at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="205" mass="21583" checksum="ED4A4FC23D42B546" modified="2022-01-19" version="1">MDCTIDKGERNSNPKVKAEGLASPIYLLKMHVTRDAQATAANAAQIFGGRSFTRMGEDMEHSLSILVAAASTVSAQCTLPDVSSASIINSANSNLEWGATSPSPPLAIVSSSFRDLSAQAWQITDISNQDLVISSPTGQDLELQSSQGLEAGGAIAQTWRITCNTLVTLVIQEAPLEMEIGDSSGAPIRIADCDGSERQSFNVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXX0</accession>
    <name>A0A8H5GXX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_001764</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXX0"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034723357" description="alpha-amylase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="34"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="51"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5373004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="533" mass="59051" checksum="A7FA86D0D0750A90" modified="2022-01-19" version="1">MSLPILCSLVAASFVLPSVHAASAEQWRSRSIYQIITDRFALPAGAPTDKCDVDAQTWCGGTWNTIRENLDYVQNMGFTAIWISPVQQNYQGPRTAYGDPYHGYWIQDATKLNNKFGTSDDLKALVAEVHKRDMYIMVDVVVNNVMATTTTPDYSKYLFKDASLYHPYCPIQWGDPNSEQNCWLGDTNVTLPDLDTTKQAVISGYASWIKDFVDEYEIDGLRIDAAKHVNKEFWPTFCGAAGLFCIGEVFGGSNVGDVAQWQGPLDSVLNFPLYTALTEGFKIPGSGNITALTDTLTQSKQMFKDTTLLGNFLENQDLPRWASQSVDPQSMYNAMSFTFMYDGIPIVYYGQEFGFRGAGDPKNREPLWTEGYQPNRATEIMTKLNGLRNFLVNKTEWATAEAQVLTSSQYGIAFQKGDVLSILTNIGSPPQNDTHIAVASPYDPNTALTDIFTCNQWVVGAQGFVDTEYTLGGQPHVLVLSTLLDQSDLCNGQVVTSQGLGKDDSSSNDADSILMSRWHGVAAVVSMLWFTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ05</accession>
    <name>A0A8H5GZ05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_000873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ05"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="82"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5373678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="482" mass="52846" checksum="E4A43B97D4C790A7" modified="2022-01-19" version="1">MLSRLSRSVAQKAGSKQLAAASTSVGARRTIVQPSGAERASVVDLPATYKDESHFTPRSDMLGFKFEMPRREGNVKEKARPIYLDMQATTPVDPRVLDAMLPFLTDQYGNPHSRTHAYGWEAEQAVEDARKHVADLIGADTKDIVFTSGATETNNMAIKGVARFHKEKKKHIITTQTEHKCVLDSCRKLGEEGFDITYLPVENNGVVDLNVLEAAIRPDTSLVSIMTVNNETGVIQPIKEIGALLRKHRGIYFHTDAAQATGKIIVDVNEMNVDLMSISGHKLYGPKGVGAAYVRRRPRVRLEPIINGGGQERGLRSGTLPTALVVGLGEAARIAKKEMARDRAHIEALSRRLIEGINSQVEHVVRNGDVEGYPGCVNLSFSYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGAAEDMAHSSLRFGIGRFTTEAEVDFVIKHIVGTVHRLREMSPLWEMVQEGIDINSIDWSQSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0I0</accession>
    <name>A0A8H5H0I0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0I0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="30984" checksum="AEA27FF4EBC35C01" modified="2022-01-19" version="1">MNLKILSHSLDSASQSTWDDISDATNDKNTTESTLSATEVDDGKQERDSHGSQRRDARGIVVYVGMEDDSPTDPPGKDNVEVDLTVSPSYSSTNFNCPAPVSTIKCTSSTNRPLAVTVSVKDIRSHSSHIQPHNPSPTIPTSTSTTVSEAAQHSPVRPGAGSGLVNSEEASFTTGQVDSVLEKAYRDLELYLERQSRRKEDRTHQTVVEDADTTNTKFKHDPDPEVETLKDEIKSLIQQMNEAFQKSEEKSRALVDELKELRKELESSKSLKIQKQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1R0</accession>
    <name>A0A8H5H1R0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1R0"/>
    <dbReference type="OrthoDB" id="3233180at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1164" mass="129165" checksum="AD1E4C293CD9EF59" modified="2022-01-19" version="1">MRSDSETESESEPESSLVAWVPTCAQPRSQDISADDVVSAVDILQNVDLSEIPSNQDLQSQILDAFNAITRFLDSLLESLPEIVEELYHFALLVRPQFLSLLFAQRKIFHQMANKVHIPGTSASVVVCCVDSFLVKMADVTLVIASGSSVSSSTLPEGLKAQQEDDSLRASSQLPGDWQAFLLSLGSRQLSSAAKRLCLKIAFAVYIIAPSLDRNSDPWMDLQNPRPHELMKALDEYVLQESVDEPASMMWCDAISERKRLSYAMVLILFCATAQQVRPDSSYTALKPRTFGNLLELIHAVLGNGDSEEMEPVENLDAAQSFLLRWGNIVPWCWKTWSDPRIDGTDSIIRLTTTWLYHIDEFPDVSSIMVDSVLEDPSAAGRAIMRVLQQCFSFLPLAALERPATLPVVLSQVCQATLTLLRHYAINGGVYDPVHFRELAKYLLNIFVALEDFERSLCIKSCILESLTLLQREGVLHIAVTSLCSVTHKDGQVRFNVKLDDLILRMRKPVIDGHQCSTSDTEDIRITIHFLTLIWYNGAAKHIPRQSFTYLLRSLIQYSQRNNDGVLRDTVLTGFAIIGLDSTSRANEQEALWELFLASRHSNLGVAASFAYYIVTAGSIPDPLRCAEAWDHLRDTLTLIMRQHFPIEEEAPALPVCDLICAALVSLLQSSTFPVSLVLASPWDSLSLSSDLKAVLHSEISPEPGYRDLLQRRLASPGKVLLEMMSGKRKSNENGGSPLETTTTPKMEVQLILYHKYGSLIIFPATTLLCSSMNYRRRSQSASTSSSFHHRSVTSPPQSAIGKRSYFSSNHSHVSSSQNKWDIDAWQSKRRRRNVSPSGSGASSDDDFLSHFNRSRSPASRSALTTLSTPRSSFPSSSADFFPRNERSGPRLRHSTHIPASFDLNSNMPYSEAELVELRSNAFWDLQRSIAENGESLVRRMRDYESSRSRAETFSKVNEARKRGRKRSSLISAARRKQVFQDSEDDEDDEGEEDVQIISGEIPDVLIRRGSRPASPGDSSLAMTRGRSLPSTQRQRSPSSCSSMVSDDDLHMSASPTFPSFDFQPHSTSMMNTPALSHSTSSTNSSMVSLPLLPYHFQSQSQPSSHSGSTDINILPSIPSPTASRSEKALAALSLAMANGAGSINDYAGLYLSSIAQPDEHWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIP6</accession>
    <name>A0A8H5LIP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-methylsterigmatocystin oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIP6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5358672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54294" checksum="04EC198366A8857D" modified="2022-01-19" version="1">MPETRKLPPSFLPRSLACAYYVVPKIDMFSLVQRLTSLDVIFLITLALITHLIRVYQRRNSWTRTGERGLSKPPGPPGYPIIENLFDIPNSKQMSSEIWGDVVSASVFGTTVIVINSYKHAIEMLEKRGAAFSDRPFLAMPAEVCEMKNGMGLLPYGKALTAERSMFHQVLGTEATIKPYYPEVERLGRKFLQRLLDSPESVLDHCHHFTGSVVLSIAYGYEVQDTQHQEDPLVKIVTDAMDRFSRSSAPGAFLVNDIPFLLKFKPLLPEWFPGMGWKRLGRLWAKEYWDMVNVPFEAVKKQMLEGTAKESFVSRWLAKDLSEQQEVYLKMAASDMFAAGVDTTASVLYAFFLLMAMNPEIQKKAQEEIDNVIGQDRLPSLEDMKELPYAYAIWKEVIRFHPPAPNGLPHANRYDKIYDDMFIPKGSVIFVDIWNLTHDENVYKDPMTFNPARFLGERPEQDPKDIVFGFGRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIX2</accession>
    <name>A0A8H5LIX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIX2"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5358778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="138" mass="16026" checksum="10E3DE48F56DF57E" modified="2022-01-19" version="1">MRRSLLRLAESVTSRPLKLQESNATLLPPIPLYRRLLRAHRHLMPEMRLLGDDYVKAEFRRHREVNNPVQLIGFLSQWKAYLDQMPQGSAGEEFRGKKLDPMVLEKLSSEQLGQLYELRNATKEVWKPEDPKDGSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL40</accession>
    <name>A0A8H5LL40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL40"/>
    <dbReference type="OrthoDB" id="2496395at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="42"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="422" mass="47603" checksum="E998EF9B5645EB0D" modified="2022-01-19" version="1">MVCKHLEILGYVASCNLDEPLHSSTMLHPREGRVDDLRWARKMDGEGYGDMVFENAILFLRDALISREFTDAVKAGDSGRILLILKIWAFSFRGNGRTKYAYEMFRLVHNLTSVWPEEVRNIILNNWLINTTGKENSFLEVGPMQEHLNFWIKVIYKAHGSNSSWEWLDMITPCIAILREIARTMNGMLGGDIGSNHKAADLTNDIDTLMTSLGEYNVYRLQQGRVLNEDEVVNDVILTGLQMLTDAGNNPLDDYNTAFKNLQKRRRMRPVTTDDEEHVVVEDSPLIPEFDPNAPQQEHNSSSNRNRPQSPLTRDKCVNDSTETSSAEMGAADGSLEGDCEGIEPETSENDVLKVLMDIEAGEREPTLLLTTEEDVALEDEDESLEGEEDEDTDGSDVEDEAVEVSEESGSEDEEDVEEYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ71</accession>
    <name>A0A8H5LQ71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ71"/>
    <dbReference type="OrthoDB" id="2976650at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="41516" checksum="93F13F86CEB2AC4F" modified="2022-01-19" version="1">MQTPLEQSNQTGEVVAVKFATEISPLDEELMIETDSKYAQTQLTSNVQANEDKGYIGVKNRELLKATVVSIRKRKQGTHFKWVKGHNGHDGNEAADKLAGVGAEKQSTDNICIRRAPALEITGAKLSTMTQALAYQAIRERKMKKEKRKNGPRRRTVRNLEKVRAQVEEAFEIVPKAEAIWRAIRHKDFARKTRNFLWMTTHDAYMTGSLWQRASFSEELQERAICKHDNQLEDMEHILTSCESPGQNVVWELAQRLWEKKSRKEWYRPGIGTILGAAAGDIKDQETEKLKSGETRLWRILIAESAYLIWVLRCKRVIANENTQFSEDEITNRWSKMINERLKLDARMTNKYEGKALSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQG5</accession>
    <name>A0A8H5LQG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQG5"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000486">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000842">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="429"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="554"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="733"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="794"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="868"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1251" mass="133244" checksum="97C6AF4D05E76AAF" modified="2022-01-19" version="1">MSLSTDTSFSRNPSAKTPPPAPSAAYAKRARELQAEQNISSARYRPPALRALASGGSPPNETLSPTASPSDAGSLPPTNHPPGFRRARAGTLPSNVQLAAQRFAAASSTLSSTPASTESLLSSTPTSTVPSVRPGLRHSATSTIPSSTVTNRLRSESLTLPPGGLSNNAFGPSLFSSSWLSNNGASSGFSVLEELRSVTSGESMDDLDVHTLDYLGLDDHRAAPATITELRTQAQAAIAGNLANPSRLRASTVSNPYRTRPSLASSLLSPTVATEEEEYDSYDDQAYARQRLHPYDNPNADYSTSYVAKGFKNDLLAPPSRPRAISVGMLEDTGRTIQRRATVAEPYINDLSQASTGLGVVSSNISNPASILKTDNKLPAVRSTPSVHFPNGGEPTSRASAYLLAPGAPNRSVSPKSEGQSSQVQTPTRSLWIGNLDSAVTSEQLIHVFAPYGAIESLRLLPEKECGFVNFVDQADAIRAKDDVLNRLGGNIGMPNGQTVRIGFGKADSAPVAPAKGTPMSPGPTSPGAVTGKTPNPSTSSGGIDAQLQSTPTRALWIGSIPSTTTPATILSVFSPYGPIESARVLTHKNCGFINFERLDDAVRARKALNGRDVLGSDVGAIRIGFAKVPVKNGQEGAAEEAAPVSVQGVGDLSVGATIHALRNVKGAITIPTDQQVLSGVVENYRSNLLLSMIASGQHNSSLMPDIAKPPSWVATVTEQQMIMKELSAGSADAEADIQALAEFRPPTMYYTTIPLVSERPHNRRWDASKLRELRKRLDSGTMTTEEIDQVAADFLDGEIVDLASDWLGNTVVQKLFEKCSAGPKFAMLERISPNLAMIGIHKNGTWAAQKIIECVSNAEETGLIAQNLRPYAPPLLLDQFGNYVVQCCLRFGPPANDFIFDAIVDRMWEIAQGRFGARSMRACLESPHITLSQQRRIATAVILNSIPLATNPNGALLLTWLLDNSGFPSRYNLLAPRFTPHLSHLCTHKLASLTVLRIVNQKIEPDASRQIAEALFASQGDHVLTDVLGDQVNGVNVVHKILTSPFIDAPDKARYVESTKHVLIELKVIATQAYRRLIEEVGLPIPNFQPTYSNAPATGKNKGGQNSYAVPGLPQGYPSNDQGLASMMAALQMGGQNPQAGPPQLHVDPTNGGRAPGPNSAFSPASDPFNPFSMQDMNNPRGIRRSGSLPVGGVSPQNSQYGTQSPNLPQGGSVLQYGGMAGQTLPPHLYQTPYMYYAQNSSPNMGTFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR44</accession>
    <name>A0A8H5LR44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR44"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="361"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="478" mass="53087" checksum="31D75C5153EA4400" modified="2022-01-19" version="1">MTSDRATAFRDFIDSWVNDLRTIHPHTREHAPRPNIHAAGHIYDFLIRYGPILNWWCFPFERLVGALQKINTNDNIGGVMESTIIKSLLNYWPAWMWKRVLISNAPFRTSRELYIAQPVSSLLTLSIIAANAATPAGYHDHIVSTSRVAEFAMVINQTREGPLVLDISLVVAVAKNWTVGFTGVIYGTIGFADPHDEKSWIFCTVRRCFGFGSQVYHGGTKSAADVLSVLPEAGDVDGRSEDPAENMEITPSCVSEPNPQSSPMDVVSTRPEAGDGWRMVGVTVHIWKSRQTAATNNRQTPGRSRLCPRRSPNVANSNALSCVLKFSVFPVRSPGSCSTRASMPMSSVAASASTSSRTDSVVYVFALNEGSGKLEYKIGSTGRTPETRLREWRRGHQSKGFRLVYSVKVVGRNTAYVVEHEAHQQILQYATKIHRSCPDCLVVHQEEFVMELDFGLEDVRDAVDTAKRLVETRRVGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS20</accession>
    <name>A0A8H5LS20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS20"/>
    <dbReference type="OrthoDB" id="2861608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="723" mass="80419" checksum="8D5D91719652738D" modified="2022-01-19" version="1">MVWAKSAPNCKLHGINLKKATPAVGAVWTKFFRNQQWDLDLFPEKFAPQVESEPDPGLALSTSPTTRLLICNVISEWRLWKLRLNLTRNHQHATTARRVEFCAIPNHLEGPVLDALRRVYSECLGELMSLASVNHRSCTTTPTVRRKRRKQREITAGKEVVTAREGYHSTKDDTHDTTRDETTSQSQELVTAGGLTSLSAGLPYTQTYVLANYVAFNDGYRRPIADTPVFSGPQIQLPRRLMQDLFNECVLLYCIFAVTSLVSIDPLIIGSEPLSAELTSILTTAQPVKRIKLDLRDIGRRRERAGLCHQLKVEALRQAQIEGIALWVSPESAASCYLLDALLDSEHDSPYSYGAAFSWQARTLAQSWYRQAQPYSNIGSMVADAMSALHSGRSVAFSAHDEHLICGHKQLPLENLASSLSQGCDCAREVYENISGPCARGRRFDFQAVKRYFTYLHLLYEVCDAFKTHGHLLSRQVQKQSWYILLTVRTVSAAWTNLTLYFYETIKAMLEEGIGTDLYNAGLDDSFPVTGVDCYVNGGRLAPAQLAPIFVDARALTCKAAIEFSEMIEDIYSVSRLAQQKIVGGNLKRWVQFTVDVMNWGVMSASEGIRILERLRDALKIAGFAWIDYAGLVEDINSHIAVLRASPATAQDSVHNLDLDRHLVIHHLNPNSYPNLPPAGAPLVEAAGTGVSQHEPPVYSGYMSGPLGSEVLGVNSEVWTYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSI0</accession>
    <name>A0A8H5LSI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSI0"/>
    <dbReference type="OrthoDB" id="2971182at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="98"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="32887" checksum="6A2699A95CC5E621" modified="2022-01-19" version="1">MPAAGGIPDIYVYFRHRRRVHDLPSLVAKLSSSSTDNLLAVIRSVTFHQRTRYERIPLLDKNILMNKYTVSAAEFLKLEKFAKFGSSKIPSVLRLSSAAVCDTGIAISLCYFLQQKRTGYKRTDEIIDHLMLFSINSGLLTSLTSIACLITYLIVPKTWVYIALCFLISRLYANTFLNALNSRHILQSDDNDMDTPVLPKFHSTEVAAGGRGRLYRGLSVKTPTQIDVLVVTETVTQSDLSRVSSSQSNSKSEPFCTTEIKRKDTGSDSSSYSIQEVPRARLSYGSKPARATITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVA8</accession>
    <name>A0A8H5LVA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVA8"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="20914" checksum="DC6570EC0A6C74D5" modified="2022-01-19" version="1">MHPNQIKVHKQPLLLPSDCQLSKPTMEALVRVTDTIKSFRETRLASIRSPAEFFDYHRFSRPADFNIATQRITYNTRYFSGNYVLVIAVLAVYAILSKPILLIALAFLVGGFTAINKFAADPVEMGGHVVTQKHLYTGLFVIGIPLLLFASPLTTFFWLVGASGVVILGHASLMEPGIESEYATVQDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVR4</accession>
    <name>A0A8H5LVR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVR4"/>
    <dbReference type="OrthoDB" id="3210666at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="52"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5371214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="553" mass="64333" checksum="B5DD77EC9ABD948C" modified="2022-01-19" version="1">MLRHSRQSLHNGALHPRTFRHHSTTSNRETPENSHFLPLEHAPFLAHVRMTPPRQVACYSRVDFNVYNYNENSSLTRFEKPKLGPIALPARLISRKRMTELHRPERVDQLLQACLGTEKGKKALLEADVIAPRNVIYKLMHGLKVSLNVSYTAGRLFLEEHEEKILYKLPRPRLVAEYCMRFKCRSPYYQPPNSYPEDVREWNAVVQRNIGGLNTLMSAHVHCVKDKYTASPDCYFELHSRRVGSSNTYPFHLQKNDVKDLAAWYLRMHLIGTPELCLGLRSPDNKRLVEMHIIPTDELPSIINDFQRSQNWPNWQPDGYITRAFRTLYLLRDWAQEAVDSLQMKPVKGQKNDEMVWRVERLRHSDRGIYVRELSREEKDRLWAVRDRPLWEGLGQTLPRRHGIIDRASLRDLRQLDRETLDSVEPAAPLKAAVGTGKYIFRLLLRVDKTERPLPGDSVTLNLAVDPRQLEFVVFVFPGKTTLPAGCLWSYRVWLRTNQVDHRLFGDDELWIAKDPDFSCITDASFARLRNVSTTSQTYEAIVGRAKINFIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY09</accession>
    <name>A0A8H5LY09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY09"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="277" mass="30546" checksum="1F11A9532C6EC8B5" modified="2022-01-19" version="1">MVVSHTQPSTSTAQTVPKKNRRKESKKSQKTAQHDIDEDMNDAREDITDTLASNLEGTADGDDDIMIDVDSSSLPNTSGVPVFEPLAADAARTLLKSETRRIPIPPHRMTPLKKDWVNIFGPLTEILGLQVRMNVQRRCVECRTSKHTKDIGAIQKGADFVKAYALGFDVNDAIALLRLDDLYLDSFEIKDVKTLQGDHLSRAIGRIAGQDGKTKFTIENASRTRIVLADTKIHIMGSFQNIKIARDAIVSLILGSPPGKVYAGLRTVSARMKQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY95</accession>
    <name>A0A8H5LY95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY95"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5373794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="67263" checksum="E4E3FFD0D0B51A2E" modified="2022-01-19" version="1">MPSVQRAANGDNHSAESELLNRLRDRPGFEPRPLKIAVAGAGAAGLCFAYKVLEGMKNGSLKSIDFILYEKDDDYTGTWHANRYPGCRCDVPSPVYQFIFAPYADWPQYFSSSSAIKEYMQIFAKKFDIEKHIRLRYKVTAAVYEETTAKWHVTVEDIASRASFTDVVDVFIPATGILSHVNRPEIPGLDTFTKKPVLHTAEWPADLNWKEEFKDERVAIIGAGSSGVQTIGAIGPYTKSLDVFARSKFWITPPFLAEILTDRPWELDNFTYSEEERNRFREDPDAFYEHLMYINRPMSIFYDYYKKGSPTAVQGKEIMQKFMQEALKREDLIDKIIPEYACRRITPSQSFLDAVQLPHVNLHTEQIKAVTPTSVIAVDGQERPVDRIILATGFDTTLRPRYPLVGRDGLNLSELWAKRPKAYVSVAVHGFPNMFLMGCGPGVNYAHGSVLLGSEVNADYIVKALSKMQRQDIKAMEPDLQAQNEYNQVWEIMMEDRVWTDGCTSWYKAGTKDGHPDALYPGSALQYLELLSDPRWEDWKYTYQYASRFSFLGNGTSTVENTPGGEMAPYIHKEQIAENTVSKPRDMNGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZA5</accession>
    <name>A0A8H5LZA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZA5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30053" checksum="BAD632414DB5BEC5" modified="2022-01-19" version="1">MESQCACGAPFELDKLAFQFSCGHRLCHCCSQNPSLSVLCSRCSQHQSSAPTSNPIPSHAIPIILHHNAYAAVLALEKDKALRQNSELQTQLESMTAHRDQLWLELVQHSHPPNLKREIRRSNCTDNTTSNQPSQRLEEENAKLKLQFEAANSALKEQNDRYQAQIADIKAKSSATICELKANLKVAIRSEQDVKSLLEAKTQEQLQSLEQAERLRAELIRTEGKRVYLEEVVRKYKAYAHQIKMRCKGKDRTPRPNSSPRRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AZC1</accession>
    <name>A0A8H5AZC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000520">
        <property type="protein sequence ID" value="KAF5313806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AZC1"/>
    <dbReference type="OrthoDB" id="3131427at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5313806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="608" mass="66838" checksum="817AC51876AAB9F5" modified="2022-01-19" version="1">MAQPNIGPKITLTDETSNASVRTDPTILGATSLSHWIPEMHPYTLSAGLGPYEREAARSHEIPLSNRSSRSEQIFVTPPTTPQAFSSTAQYFEGTIHDDSPGPRPLDVQEDVDAHSISSRQTESLCIVKRPFIRATNIAALRTGFSDETSHFLPPPDELRVKSTLSAATQNLTSTSLPSLSPEATHRRYASESVSLTKLPFIKRPISRSTNIQRNSAYKTQRIAGTSSSLRLGVSSPSQRHHSRAFSEPPTMPPDIPLPSIPVSQSSSPSFPSSHSDSSQSSYSPPSLGNQFTNRLTLPRTALRLSSLGDQAKRSSNGTRPREPILTTPPVAHMYALRPVSTAFSGTHPTARYHLTNDPVVRSHHHRNRPWTISNSPSARIPTTSIRLSQISTFSQLEQTEIIEDENGFAYYRYRVRSSGIEEGGLGSSSGSRRSSMPSFPADVSSSSVRTSSTSPKTNGRRAPSPVLLSTHHNMPLESSKILCTPNSPLQIRVHRDSDLKRSAEYPRPLSQAHAKHASLDPRLQIRSHSSNVGSGPGLGGLRSEDNEVDANRSYEVVKPWLDPRNNPNATRALVAYWLVYGIIFLGFVGGVLDCYFGYRRALREYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B2Q6</accession>
    <name>A0A8H5B2Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000493">
        <property type="protein sequence ID" value="KAF5315512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B2Q6"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="592"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="722"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="862"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5315512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1160" mass="131081" checksum="9CF9B5AB682AD5D5" modified="2022-01-19" version="1">MMDMSRYTHNKGKGKATMRFLDIEASDDEDDTEFGDEDPVGSGDELGVGSDQDEEDGGMERPNTNGNCYDEDDDEPLPEDNMTAEEYLEHLATKYTQGIPESNKTGANILQSLPGPIRTSLLTIENQQQFWKVKCKSGQETQLVLDLMHFALGRGPVSAPSQDLDSEPSSSGALQPPTTAPHTLYPYLNTHYLHRQPYRRGAPGHKWETTMANRTPEDSEDPDGWQDQAVHGWELQALRCVEKIGKFALDPEGNIANLTEEIIRDLSVSKLPVIWRQAIDATSIDPFEASEDPHAGKRRFEEKHVRGLEKWIDTVKSTALSSSSSTSPPQRLPRLRNVLSLSTSPDSHPPPSRLIQAQFRSAFTVAGISGSVYLEADLGSYPQETDIVAFLRGHPAVPIGSVIKQRNDAGLTRAWVSLQPLTANQVGELLNWRPADIKPSQWIKVTKGPYKGDTALVVRRVFDTGQRRLLITVIPRIPEEKVDDDDDEEQPILPPALELQAKRKAENDRPTQHLFCAKDHPGAKELYFQGHGRGKIFEYKGEEYHYGLLVTTIPYSSASLVDVDMDNHSRRLFKASNSPYIVSSLPTPRDWHFFVDDRVEGVQSEVLAGIDRDVAKESRLRKGTIKSIDGDACWVQFDDLADFAEEGTVVKIPKLNLLKRFYVGDWVIVEGGPSAGRTGWVLTHFDESLVLYYDKPGTQEGEEFSAHPNECRLTTPRTEGVAPWINAHVHIVAGKVYKGYTGVVLDVSKSRDGFVMLQVDLSSVGISVWVRHDDVKETCTNKSLRRAIPLKPHQMGLWQITWPEPSAKEQEQDELPRAPNIPQHYRDSLNISRSSQMVPMLDPHNQQLLTPENSLLLREPSNPWIGKECVVIRGPHKMQGWVRRVRRDHRKVSGLAVLVELQLITTERGGDPRHEVDYTWIRDQTTGLPLHARYPLTNVQRYWEPLIHVKAIPVKNPCSYPSLEPLPRRGPSSDGRPMTPEPEMSVDRWDWRVDRRLDRKEFWASYQPSDGGKRVDKVTARVDYNTKKIQLRMGGAWISVDPVEVDSVTRWSNPKTARFPMLVKQGHHTGQIFRPIFHDYQGEQLVLIGAVYDNWGQASEVFLEEIRVKYEDCLHAATDPNKKHFADEVAAKRSSYSHPEETGGKRRRPKPKVSRLSNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6B6</accession>
    <name>A0A8H5B6B6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000485">
        <property type="protein sequence ID" value="KAF5317436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6B6"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="171"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="719" mass="82086" checksum="47CC485C70A577A9" modified="2022-01-19" version="1">MFILEWLRSKNCFGLGFTEDRLPLPGEDDLSRIRRLIRRNQMVEGGLYIGPAHDSLDKDCERGGMGLWHINHFESSNSFPEYNIGLLYFFFKRDTLPKNNSLLTNFIWSRGVEEESRTSSTLNLAHTWLKDCSEKHEVCQKIIKSNTQLPTRVIDVNGPHLKITKGLTGKYTALSYCWGQDSHTHLKLIKNKLDAFQGNIPWVELPQTLKDAIFVTRGLGIPFLWIDALCIIQDDREDWRTEAACMNDVYRNAVVTLFAADSASASQGFLSNRMVKPEVALSLSDPESRIESSEIFVTYASSEDSDSANHETRLLGGNPGPWSTRGWTLQEYLSATSGIFFTKHQMSWYCPTCVVKEDGEYVDLLKEQAEEIALTLKGTYRHMNLTEISTRWVVLTQMKQVYLKDISDQIYHKLLLDEFHEIVNDFLHRLFTFHSDKLAATAGVARIMEENLKLQGVCSIYYAGLWSSNWVSGLQWESNHNRDFLCHSMISKKESSNAPSWSWASIVNAVYSRNVIKQSFLTQIQSPIADDQERFNPTGHLVLKFNAPLVYLSDMWMKIHSQEDGNIAQENPGILAFEKILREILCLDASDSERYLGTEFAQKHEPYAGQQFAVIKVSLSQNWIRPGPDDYDSSQSSPTSIDTDSTSLSVAEASHIFYLILESVQHYQGAFRRVASFELPVKREAISYFIKSQPTEGRHGRTSEMIADLPWKEERVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BC76</accession>
    <name>A0A8H5BC76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000432">
        <property type="protein sequence ID" value="KAF5319763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BC76"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="331"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5319763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="463" mass="51166" checksum="604C4E7179E6B82D" modified="2022-01-19" version="1">MTTTTAKVLLLTNSEYGQANVFLALAHEFSLRNVDLDLASFPPLLKRLTRQRLTEKLTFHTIFGLSYEEALTRTADTNDLSHPPGVSGAIQSYRYVVDGLFPWTAEEYHQQLLSIQSILEEVRPTITVVDSLLNGALDVCKKMNWKCVVLSPNSPKDYIGMSQPALRGFWKYPALSSGFPYPVPLTLIPANIYLNIRMIIKVVTSPIAKSYDKIRKDSHGLAKTVIDQFAPDIPYIFPALPQTEFPGFHFPTNINLCGPILLPSTPLESFDSDTLQWLNNPGLKTILVNLGSHVISNADHIRELGGGLRILLSKFSDVQILWKIIADGEVQAALTEVVDGYRMKVVDWLQVDPHSILYHPDVICSVHHGGANSFFEAVSAGVPQVILPVWYDTYDYARRVECLGIGVYGSANSAPRADAQEFGRALIKVVGEASFTQKARGLAESCSSEAGRKLAVNTIMGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BCP0</accession>
    <name>A0A8H5BCP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000432">
        <property type="protein sequence ID" value="KAF5319762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BCP0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5319762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="229" mass="26182" checksum="F76643D1AEDB7E5F" modified="2022-01-19" version="1">MSFNNNAIRIRIHLPEKPIEDHFAITKKILTNNLNDEEVRRALKNSIHIKSVAEAIFMMQGHRRLLQQAMKEVDDELDKHTKEIADKGLWGNGRNNWRKEKGFMQVVWPKPEEFFKKPTLNSLASSQGGSAFGTRNRPIIIDRSPLPASSNTVHCYWCHKDGHFASSCKHFNCYICGEFQPGHYPSQCPHRSTTGRDQHDYRPDSPELDPGGLDNVAWANITGEPMADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRQ7</accession>
    <name>A0A8H5BRQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000375">
        <property type="protein sequence ID" value="KAF5328011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRQ7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18027" checksum="6DA1A4B982A24830" modified="2022-01-19" version="1">MAPSAVAFASSRVGQSSTISPLPGYPEDGLVEGYATVRNAGVPPEMGKGKRDYDVRRMGHEILHRSRQGGRIIWKTGSAVPVDKYGEEHQYRHNDSNALNRWKLSPPLLLPLPSTAIATTPQFCCGRSKIEASLYEGFGMKGVICQPAGVYWAESTGWSPHIEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BV13</accession>
    <name>A0A8H5BV13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000335">
        <property type="protein sequence ID" value="KAF5330092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BV13"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5330092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25783" checksum="C34E3F3DDD01379D" modified="2022-01-19" version="1">MYLILKGLYKGLIIIYLRYPRDSSPIILLHLDIHSRVSWSPRSSFTVPTCPYSLRRLHIQQVRISPYNSKANGVVERGYFVIRESLVKAWKGHITRWPDLLATVVFADNITVQRQTDSFKEGDLVLVRNSRVSNDLGRKAKPRWLGPYAIVRRTKGGSYVIRELNGAVLLQGIAASRLLSYVSHSDPLLQQLAAGLPQTDDQLDTDWREPPAPTSDSEEDDDDIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZ13</accession>
    <name>A0A8H5BZ13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000314">
        <property type="protein sequence ID" value="KAF5332070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZ13"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5332070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="137" mass="15119" checksum="585B440EDA1B7BD9" modified="2022-01-19" version="1">MSCWNNSCATFPPPSLAMFDTYTTMLTLLPRADTNATSGDSENPYGYTPNFTISTMFMALFDITTVLHLGQAVFCRRWFLLYTVILAGAMETAGWYGRVWSSHDVINSGAFTLQIALTIVAPTPLLAGNFIIFGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C017</accession>
    <name>A0A8H5C017_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000309">
        <property type="protein sequence ID" value="KAF5332364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C017"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="23929" checksum="57750554DF3F92E4" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFARRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDSKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITVKPPVLHLKTKTLKPAVIDPRTHHKEYQDDDVEFLFDPSTEIRKKPQSLPKMTTGGTRSQNGGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0F9</accession>
    <name>A0A8H5C0F9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase UstS-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001004</name>
        <name evidence="2" type="ORF">D9758_017369</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000305">
        <property type="protein sequence ID" value="KAF5332386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0F9"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="90" mass="10560" checksum="9C4589A7F8DE145E" modified="2022-01-19" version="1">MGSKWAPRDLNEEMTEESVEDSWKRFESRFGELAKTIGDGPFVMGNQISFLDDCALIGWLMLLRFTLWDDDKGKQWWNEIMEWHGADEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0Z6</accession>
    <name>A0A8H5C0Z6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000293">
        <property type="protein sequence ID" value="KAF5333003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0Z6"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000043">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="67"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5333003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="43241" checksum="EC6B3EC1E7C59E16" modified="2022-01-19" version="1">MAGLSHLPTYDIEDSNIALLGSDLEKRVREHAGDIERAWRNAGTEPCIQIWRIEQFQVVPWPDDKKGCFYDGDSYIILNTYKKTPEAESLSYNLHFWLGSNTTQDEAGTAAYKTVELDDHLHGAPVQYREVQGYESERFLSYFPRFLTLKGGAATGFHHVTDPPPLDLQNLYRITFYQTGARSNLVVRQVPAEAASLVEGDVYVLDKGTKIWQYNTKNSLGKEKFKAAEFVHSIVEARGSQCDVTVYDEGASGAGIFLAEFGEGTTLRPQPEAESAESTPPITLFRLSDASGQVSFTQAEPPTYSTLSSDDAFLIDASADHKHPVVYVWLGKNASLMERRLALEYAQKYLYDKRDKVPESEKVDARISIVKIQEGNESDGFLKLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C1T4</accession>
    <name>A0A8H5C1T4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C1T4"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="832" mass="93782" checksum="E33356D7C5BAFDD7" modified="2022-01-19" version="1">MAVESRGRVGGGRLAVDSKLVKRVVIQSGAPIDRYIPVVLFMEDIGNFPCETYEQRMKRSAEIENWTNGIYRPAPSDYVPTSPRMVTSLVNPTKHSFPAPLDNLLKGGRPSTAYDMLDSSPSSNWKQPLYAPSVKKCTPPDSPSFRNLRSTLVDGLARGTFNDSPCPFPLHKAVPQPPPDYEPFNFSLAPTITSICHQGASFPHRADPCITSTPNRRIHVLVGSYLHWNEPSFKILFDCFAVGASLGVLLDLLGSPAPSHLSVDVETSDFQLGMPDREKFFSNFIQRVYFLEIQGKPRYGEVLTIEDLFGGTSSGFMKVLKTVQRLLDALQATYPGLSMFPDPTFTQHDRRDIVMELVDTEGVHVSYLQLILDSVATLSCASNFMQSTLEPLVINDNWLSMRQYHDRVLKDMEAMLLCMERSDFNGDAEDWLHIFGFDNPANRTNIAATYRSLSVNYLDIFEVLPEQKKTIESSSLTGNIQIVLDVLFILPARIADYCAWLQAISDCTLPSLPVLPTSSFSSPLSWFDTVCITLYHMSQISSAIDEMSWQIQSIQALRTLNQRAFHWNASIDPSQLGNLLVDDQLKIYDADSGTGLKPNPKDEDAKIYQVFLFETMLLCCLGEQKLQKHRRNGSGSGSRSTRKGDVELDPHAQKTGTAYSTWASWTEWTRNGWSLWGRQRRDLEDHDPGSHQNSTQSDGDEGHPRYPVRSWELGSALRKKTPLNLIYTIPTAWMKVLSVDEELFSLDWRDNEGIGEKYALKLSYSIDQSDQWLLVLEGFVTEVVDVFVDEHLSNQLRESLDGSSIYEIGTDIFNLDDDGFYIPDRHYSRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4F3</accession>
    <name>A0A8H5C4F3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4F3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10258" checksum="0B110CB1AC0861B1" modified="2022-01-19" version="1">MSPAVPGLLPLNDAPLVYLVSRILVPYPRCMLFLPTRNITPQKPLVFSRRPSPFLPAKMSHHGCISHNLEGVITLGKEIAESGEHDWRESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB56</accession>
    <name>A0A8H5CB56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000195">
        <property type="protein sequence ID" value="KAF5338565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB56"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="40736" checksum="3D6B40210B3FA85E" modified="2022-01-19" version="1">MTSWLGRPILGDAIGVTSRGCVPMMNSIYTDDVAIEIVFGIIQEYMCPYLMSQIVVFLSFLQMSVLSQNSPTMWDYPGASDYGKTREQARRCRGVLGLIDGDVDCLIQLMADTDAIIFKSAAVVAGMHYSPKRLEVIDVAIHATHVPCWREYFTPKGYQFMDNGPINGLEMVCDTVWFGTTRSQLKKTLAIYAIREGQKSMYHFLLLQTSTLHSTFFSCSAWVVFYSNDFDDHNIMHAIEDVVELDFTAVSDNSMDSVRCLNCPAIPRAFSGGSGFCSIVWDEQNALTDPFAVDARELWSDPVEYSLIWCWALQCYNPLCPYYSQYPAAEPVMFRAFDGHRLYYSQDHYPNVPITDQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBC2</accession>
    <name>A0A8H5CBC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBC2"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68803" checksum="FF1D2FFD8B8C94B7" modified="2022-01-19" version="1">MTTSEIPLCTECGRTFHSSDLLAKLGDDTIPVSQVSDIERLDTEILRYNREIDQLRQSLFMLEKDRDRLVQEKETRQASLSPVRKMPNEILAEMFSWNAILPLPAGSEGFSLHHRDPKPSSYVALPILNIAHTCRLFRDVCLNRPDFWSHIILRFDSLYDNKYYQESREQPLASLLRKYLSYSKSSLLTIDLHVFGPIDPRDTEDMYEEMDADIADDEEHQRRPVFVSLLWEILAILLPEAHRWRSASLAVEPKLFRRFMKEKMDLDDEDRGFDPVYPFPLLESLSLFEDNWDTYTSYTMGWNRTFDDYFFRTLIRQLVAPHFNPNMSMPSTLTSLTVHNFENSDASVVKFCPDLTHLVILNYQMGTHYATLPKTLGPNLTHLNAFMPESGDFSLLEVLETPSLVELVLSGSRGRDDYRDPVWFMDQFAATPRVSLKKLSVSGMKISLEDLRDLLQATPYLTHLTLHDVLDPRNGLTDQFVRSVIGFVNLTKVDAPASGGGTTPTKLYHLEQLEISVTEDANYTLDTETLVLICEMLESRLGAGEGTSGTALSFFNLHTRASRNEAEGLGSDILYRFEQIAHSDGLNGGGNRRYTIAFGDSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBP5</accession>
    <name>A0A8H5CBP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBP5"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5338865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="42177" checksum="88B4D3EE908DAA73" modified="2022-01-19" version="1">MQRAVHVITQLQELAIQKAHPKPKPATESEQGTSTPTNQPSGSNPVPETPPNNTPEPDNPTSPPSSPTIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLALFNNYLRMNKGKYPTEESQVSLFLSFFTGEKGGDWATQRLIERDADEENENLANTPGEWRWITLKQIRDRFKKDFKALALEDVARTKIKFARMKGTDISSYNSIFDTYREESEFGDAALLEFYQDGLPPKLREAVGRTYPKWDDFEEYKERAVELHLEWLKERERQGRWKTTSTSKSSPGPSQGRTVASVNALMGPGANSSFNLPPKLTPDERDRLQKAGACFACRQTGHMSNECPTFPRTSSQNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDN1</accession>
    <name>A0A8H5CDN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 76 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDN1"/>
    <dbReference type="OrthoDB" id="3068171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65156" checksum="B180EB53819EA0FA" modified="2022-01-19" version="1">MMDPCSVSPPQPQRRMYVFYSKLLLCWVLVTSYATQYANSQSFKSPSSWRKPDITTSSEDRVNIASAALDKITGELSAQAQSEDLPYSTTGRSVYAQMAEFDRLTNQTKYKDQLKDYLGRAQRINAFSDTFYRSRYIVLSAYGYAAAWAYAAYKDDDFLDFAADSWSFGWNYTLKQDEVDGKSTPVKDFNISQTCQGITMAGGTFWSTNRTQASLNGLGTGLSAALAAVTSNQTYLDAAAQSLSFIHAHLYNVDGVVQDTISASEKDSCATSNGVFAYNSGLMIEGLAILAEVTENVSMQELLRDTVAATIQKNKWQGDDGVMNPPDDFLIRGLSAAYSRNTTPSDMRGYLKDYLGFNAILEQASNGANIYGSSWVGPPYSIYSADNQSKALNGLLAAIPLINDAPSTNNTDSFGGDEQSSSNSKKSPIGPIVGSVVGGIVFLSLCLIGAFLFLRQRQNRRQRRKYRSQVSFGPFDSMATHTRTNSESSLVIRQAENENPGMSLLYTQNMSEKARRQLARHLAEQQLRSASLSENDRTSATFSASPAGNAASDPHMSTVDLVRLLNERLQPGQWREELEEVPPEYIEAGSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CES9</accession>
    <name>A0A8H5CES9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CES9"/>
    <dbReference type="OrthoDB" id="3098341at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="35700" checksum="55740506A94539F6" modified="2022-01-19" version="1">MVSSYPCDSISTSPDSFDSENVSTQLLRMYEQVLDPRMLATLEYNWGVPRGTIDLDASHNHMQLRADLSSLLHFCQVGFVPTPETFQAMKEHASTGRKPRPYTDSFPLQSYEYMFLAGYIETPLYVKNPETGQVQRFEHPYHGLPTFTSSAHPFHVLHQATHCVHSCRKEMIVQYPSAASLSHALVEVCFSWLTEPAPELFCYESEAEEEDDDDEASSDESTSDLSPLTPPRSKTPSDSERQCCSYVDNKWIAKWIDQTQVAGYGKESVHNSPDPQLKGYRKEPSFLSEQKLASLVLAYSKEQSLLSGDEMSGLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFK9</accession>
    <name>A0A8H5CFK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFK9"/>
    <dbReference type="OrthoDB" id="2677917at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="546" mass="60897" checksum="DA8308129881CF25" modified="2022-01-19" version="1">MVFLVFRDWVDRPVSARVKRDAWVCSDCSVQEDIEKEMVDAGLIPPPQPALSTLPLKTENPRDSTISLNSRSGKNAAVDEEEEAIRTRLEAIGLHVGVNFAERLCRETLDVIKFVCKDLWAACWDRQVDNLQTNHRGIYVLQDNTFKTITHLSSWEGRADATHKAKLAATAYTTTSDADAPCNLSELWIDGPFGLLSAPVYDGASLNTDAESTNNETNQCSYIPKGNNIKSIQCRRKDSQKSINNCQEGTGIEEGQTSTSVIDVDGSDSASESGESESSPEDEALELADEAELRQKMKTWTAPVYAFYDPIPTIEYINGRKCQVFKCSGTACHKEIRRYQDKSDANATKGLRDHIQSCKCWGAAVLENVKNLKGDEARKAARSYLKDGTITAAFQRVNKGTVTYSHRQHTKTETHAEIVCWVAESARPFTIVRDCRFMCLMKTGRPGYYLPHPTTVSRNVKTVFAKSQRRIASLLREYDGRLNFATDAWTSPNHHAYVAVTVHLEQEGVPLSFLLDFVELGKILKDATVYFSRSTPNLATVIPSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CIC5</accession>
    <name>A0A8H5CIC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000168">
        <property type="protein sequence ID" value="KAF5341303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CIC5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5341303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="98" mass="11306" checksum="55F47FCD9EB4CA28" modified="2022-01-19" version="1">MQYLADCSVLIVSAALAVTKTYSRQSKQEFPALMQQINQLVLDHEVNLKLHSILLSKSVEKLRSTSEQDFFPKEFIRICREQFTLLSEQLLKGEMTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMH4</accession>
    <name>A0A8H5CMH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5344004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMH4"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="287" mass="30513" checksum="B5E3774377FEAB70" modified="2022-01-19" version="1">MMSMLFRRFPLGSASFALSTKRSLATSTKTAIITGGAQGIGKGIALRLAQEGFDICVNDLERNASAAEDVAKEIRSLGRNSITAYADVSSQAQVREMIQSSVKALGPLNVMIANAGIVEMKWGLDIDESDPGHVRRILDVNVCGVVNCDVEAARQFKEQGKGGKILNATSIAAYRASPMQAMYCASKAAVRTLTQTFALEWGPIGVTCNAFAPGICRTPMWDQVDEGLSKWNGLPKGQNFENWKNGIALGRTSTPKDVAGLVAFLAGEDSGYITGQTIIVDGGIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNT6</accession>
    <name>A0A8H5CNT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNT6"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="446" mass="51860" checksum="9920D26B154EF27B" modified="2022-01-19" version="1">MIMSKRQRHYSPLSPTSLDQTELVKTTLDDDSTLMLIDKWLEHRQPHEAYYEWFRDSRDRRQIPNQRQILIWNKGEFDTTNIFCRTVDTGRLMPLHRMWTTHVYCHRSMQERKLPMLQVVFTMLPELLLLRGMHENCSEIYIIVTDLKRQEMDDVTEYFKLVSRYSFGRVCKPSIERQIQYEHMRISHTLHRRHRLPCFPQIDLTLRAIIAEKKPPFLILFSPQPTSYSQILFTHPSYVPDEEIFCDYPTGCPNPCCTEDCEMIRFPRRGLESASVLEIYGGNNRGFKAARVEGGEASPEKDKVRKKIRKIKERDMCNWIECDACFSEQLAQPSYAAARMISARSDKDSNSDGKASDARKDIDGDSGSHCSAESMATSEESHHNRNSNTNDGSPAEAPSHHAKSGSISRPAGQLCSKCKLVKYCSLEHQRLDWEEHKRVCIKMNWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP30</accession>
    <name>A0A8H5CP30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP30"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5345018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="39288" checksum="33CB50C2238E3671" modified="2022-01-19" version="1">MGRTKSTISTEAPPEIQLALTEETQGAGVKEASSVELKKLDRAVEFLAAYQAQHGDIPQLSPKEEREMVRRFDFYLVPLITLSVTMGALDKVAVGQAAIYGMREGAHLQGQEYSWISSGIYFGTIAAALPQMYFMKKFTTSKYVSVNVTMWGVLSLLMAACSNFAGMMTIRILLGFFESIVMSSALLILSGFYKRAEQPVRTAICFSTFSSVFNGLLGYGVSFAPTDHGIAPWRIIFLACGTFTVCLGITMWFLLPSTVMDAIWMKNPLRRAQALQRVKNENLGTENHVVKWEQVWEVFLDPKTYLVFLISLFNNIPNGGLIGFNGIVISRSFVHEIYQFLTTTQMASATHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPF8</accession>
    <name>A0A8H5CPF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000122">
        <property type="protein sequence ID" value="KAF5344588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPF8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="42774" checksum="F576177CEB709516" modified="2022-01-19" version="1">MQVFTQLSHGSGVLIYPIKHLFLLHRYRHIIMDVSAYRATQVSRGFTYRYHFTAPKEGHPTIVFIHGFPSTAYDWHHQIKFFKEKGYGLVVPDMLGYGQTSIVFDAASYKHTLLAKDVMDVLDTEKIQKAIVIGHDWGSTIVSAIVQIYGDRVIAAGFLAAGYTVPNPKFNYEAVMAFTKEKLGYEALGYWEFFAGEGADKIIEENWDAFQALVWCEDPKEWVTYLSPRGALKSYLTSGQKVTPASWLTAEVSVTFTYGALWSRILTLPLPCHTQDRKTQMQTLLMGGFTGPLNYYTVVVSGLQAEDDATIPEDKYVTDKPVFFGVTVEDDIMAPMQKATVEKFAKNGTIKEFKTGHWVQMQAPEELNKELLNWIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRC9</accession>
    <name>A0A8H5CRC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000106">
        <property type="protein sequence ID" value="KAF5345999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRC9"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5345999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="622" mass="69036" checksum="47533955011BBF8B" modified="2022-01-19" version="1">MDVLVGETSSRSRKRVRFEDSSEGYKTQSSKRPRIDAYPFVVGSSTSTVSGGQSSWRPSLTDGSIQSLPIDEPIDEEDFEDDPVDFDIVSWQKLLRRLIQADSLEDTEPFSSSSEPSSSTAMPSFDDRASIPTTSETPATLIPPSIPTIPEIPVPSITPCIPTAESTTVIDPFDDPNVSWVSHPLLPPNVLVPTDQGKWPLVLQSFLREHLGGPTPFRDFLRSIRPKWPQVVAQVLGMSEEYGEFGRREGQGVRDVEEASSGVSRHPQSSWAGHEDWTSTRQVPVATNGAGGNDDEEEEEEEWSEESDEDIDEVLARRAVAQNHMERIDELDSRGHWEVPSLPVQDISSDRHSLETSGFHPSVDEVLDDRAQRAQNLVESRDELDPHGRWEFLSLPVESSSSGRSSPATSNFHTLESDHCDNCHQAEQTMPESDPVDESYSDPSPSIGHIHAVSPAPRSNDDTNDQASDDEDDDEDEEEEQTKLLLSSYRCPICLSPPRNATLTPCGHIICGACLFQSIKASGYVPPLADEVGDVVAAGARQFDDAEGDDRLPVIYDGQGRRWRWRYRMNERGGDRGRIFRERVLDNGDREPRCPVCRSVIHGWNGKGMGVVGLKVQVEQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRR4</accession>
    <name>A0A8H5CRR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRR4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034904886" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="38"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="578" mass="62750" checksum="0D90B94AC1B669E4" modified="2022-01-19" version="1">MPITPLLLILAFLICTSVSASDPRVSMGDFTFVGRQISESVEFFGDVPFAEAPVGDLRLRPPILKNFTAGKEIVFNATHFGPSCIQTLVPAEELSEDCLTLSIFRPANLALEDKQHGLPVMIWFYGGGYIVGSSSMYDGTPLVNRSVFRGTPTIFIAANYRLGPLGFPRGDDVAREAASGSRILNLGLQDNIAALQWIQKHIASFGGDPSKVTVFGESAGAGAIEFLLLSSALKGLARAAIMESAGGFPAIPPKSSSANTVWNNFMAALPQCNNTAMTDDIECIRQLSTPEIIDGFNKAQLFFNTSGKGDWSPTADGITVPDLPSTSRPDYGLLEAVMMGNNKDEATLFTDQMTNSTQAIMDMILGSPPSPPNASPSQRKIQLQKLRHILNETLVLYPNVASLGSPFGTGNETFGLNPEYKRTAAVSTDFLFNAARRFHINQRLLPAGISTFSYLFADPDAVPVQDFVSGNPAPGSLGSTHSSEIFYVFGTLKDRPELREVTPTAAKLSKMMMDYWISFANVLNPNDGKGSSRPSWPEYEAHRHVLMQLNGYNTTAIMDDFRERQIALFSRDPAVFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS22</accession>
    <name>A0A8H5CS22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS22"/>
    <dbReference type="OrthoDB" id="2668963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="319" mass="35712" checksum="BF6BD9669954A637" modified="2022-01-19" version="1">MVGRAKNIASYELSELKKKAVQRYLDKLGKPGGEKKLGLREVCRAISDDHFERTGHRIALSSTTLARHVKGGQTIMEFNATKHHLTPEEQQKIVNFAVECGDRGFPLSPRRIKQHAEHILKCRLGSLALEKGLGKDWATRFINKHHGELGRYWSRPLDDKRGRAVNPVTKEEYFNLLKGCREKYNIPDELVYGADESGLQTGIGSKEYVIGRKGASIVHQQRSGDRENITVLPTICADGTCLAPAIIFKGQGYQTKWLQNNPIDARLSYSKKGYIEGEIGVAWLEDFDKQTKGKAAGRACLLLVDGHASHYTHGFLKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVF8</accession>
    <name>A0A8H5CVF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVF8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="354" mass="37759" checksum="3B511160C5566A3E" modified="2022-01-19" version="1">MVSERVSAERPLSPFSQFRSKRKLHSASGNEFNATTINGVPTSTKSPTTTLAKTTTTKTTSTPTKAEADWAPSSWGVTDSDPFAAPEPGAALADVSGLDKSTLSVASTFAGLSVVEEFHQDAYGSRSRSRNRTRSRTRSGTRSGHGHYDEYGSPGHGHETEYPGSPELGSGNTTRMSAWGRLQLPVPSSASVGLLSGGGDEQVGSIRRSGGKGSQRQECSSWVDVTKLEEEEEQDEVVVQEGLIAQRLLKKLNREGRGKGRGKARVQAMVSRGRSGSGGRQKNGAGRLGGTEEMRPSSSTQTLGSGISWGAARSFLLMNSLARERERLTRDTSTSGNKQSFAPSNLRPIVGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVX8</accession>
    <name>A0A8H5CVX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVX8"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5349026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="194" mass="21914" checksum="56C917C2A1F9E260" modified="2022-01-19" version="1">METSFAITGKGYIIVAADTTAARSIVKMKTDEDKIKTLSPHLLMAYSGEPGDTIQFAEYIERNIRLYQIRNNYPLRPPAAASWIRRSLAESLRSRKPYAVNLLLGGYDTTTYTPHLYWVDYLGTMTEVPFGAHGYGSYFALSLLDRYHDPEASLEEGIVTLKRCIDEVAKRLVVTPGKYKVKVVDKDGIREIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVZ8</accession>
    <name>A0A8H5CVZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVZ8"/>
    <dbReference type="OrthoDB" id="2989813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="270"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="4">
        <location>
            <begin position="449"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5349056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122709" checksum="1E390403F076A4F1" modified="2022-01-19" version="1">MRRLGGALSATLLMCYLDQPQHPFLDSMTYLEFSARCNIVTHDPVQPVTDCEIVENIVPNRTQMRIWLLAESHRRVVRIVMVYPRHGDVFYLCCLLMHGGAFHSWEDICTVDGVLYDSFADAARAKGLFDNASEGTLAFQELVEVGASPGQLRWLFCVLAVEGKIVSLLTHPDENAVHNEALLLLQQLLCGLGKCLSDFNLPEPQLHQTEVDAEQMRWNGDPHNLSGFLNSLTVEQRQIYNCIIAALSRTGEIILLSASSAFAAKNYPGVKHGGSHAQLLLAAKCHVIDEICGLHFKAFNCADRLMRSLTGNLQNVWGGRLLITLGDFRQVAPVVRFGGQTAITKASICTQPVFHKFEVHELTQNLCQSADAPFAQFLDSIGDNTSANCIDLSPIRSTSSVEEATLFAFPDSVLADPHQCTTRTYYSCDSAHTEDDTQSREQEAVTTVDFLNSLKEPGVPAHELNLKVGAIACFTQNFDPSKGLMKNTQVIVHSLLRHSVEVETIPEIIGGRHARSECFHVPRINVQFTPSGFNFVVNRKQILLVLAYSTTFNGCQGLTVLNGEPIIIMSSQTVLTLATLSLINGQKEAVNGKPMFVYNTLFGLDTSARDALYHTYMRPGTSFHVDNSCVTVLAKANIPPNPGLPIILEGIVELLHPGVPTNDGYQDSIPVMEAPFIIATGNVLQTTSNNDGKVFAMSTTEYMGGNTVSYTLHSMYDPIHSRWKNTSLLHLGNHVFVIGQAVDFNANNVLTLNVEHIVLNLAGGGTSTSALPTPAPSAPTSDDDGPPTRKRRYNARQTGTRSNALTIVADESSINQVSSAGSMVDTASQEVDMSVVTTAASSGHEEHAIQPYISEAEAARRFFAALPAQHIAELMAMFTLNAGAVTGPNNTQQTIPAVPTQYGTPEQNVESAMMALATRAPSVGIQIQDQTEKGSAKWPIFFRVSDHNVYGKLCVMFAEDVTRNWVTVSCEMILDICAWLNDPSIPDLTLVKCLAKVLTPMTFMYAPYLEHVLPSYSGLHCLMLYPAVLEDQKVVTNIRISFMLEVTSGEAVHQFVDFLLGLVDCVRTDSPQQFPMVSNLSYACGFSNIFGFVDFMGLWTDLLIREGNMDTALPELVYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW77</accession>
    <name>A0A8H5CW77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2 type CCCH zinc finger 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW77"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049017">
        <property type="entry name" value="Nab2_Znf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21803">
        <property type="entry name" value="Nab2-zf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2 type CCCH zinc finger 4" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5348708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="601" mass="63336" checksum="D8933CDD7B82EA6F" modified="2022-01-19" version="1">MPFGLTIGTDRATALQNSIQDELINRGFSPDADPVMAEYITIMIINNKTADQITAELEDLIGADFDRSFTDWLFAEAAKGSPENETSRPATSPSTEQPPPLPTTSNDSSRRVNQTPRNGVYQQAISQALPSSSNKRSASARSPSPNHPNKIRRTDLPTGPRAMQRDGQSNSRSLIDRMSSGPPPGNHQNGLNQRDEIQARIDNIVNSDPSMMMAGGFPAMNGMDMNAMNGMGNPVMLQELMMNQMALMAQITGMINPGQFGGFPVQGMMPGGGDMTMMQNMGMNGFQGAPHGHGQGGRGGRGGRGRGGGDRGRGGAPASVSTPKPEDKSASTSDTQSSSAAVPIVAPTPSATVPAPSATPSTTPALARPAYAVPERPQSPTLCKFGLLCTNAHCRWSHPSPVATPESGVVLSNDPCEQGKDCKDKDCVKAHVSPAVLKPHQSPAPPQQQPPSSSFPPPNTVPCRFGTSCTRPGCTFSHPRQSSNSHYAQPCRFGASCTKATCPFQHPEGRVLPTSFHRGLSTTAPLVTVPNPEPGSIGGPSPHKSVTFNQSGAGIREKLQKQMKEIEEKKSEAEKAVKEAEAAAAASGGKKDDSKPVPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWV6</accession>
    <name>A0A8H5CWV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWV6"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71032" checksum="0DF8716573EC7996" modified="2022-01-19" version="1">MKVYELNDSAVQLMEHFRQSGDCAEIDSAVQLMEAGIKLIPDGHADKAARLNNLGNAFFLQYQHLGKLGDIENAIHFKCQAVNLTLDGHAHIAARLNNLGNAFESRFERLRELGDIEKAIRLKHQAVDLTPDGHADKAARLNNLGNAFSRRIERLGELGDIENAMLNNLGNAFFRRYQRLEEQEDIENAIHFSRQAFDLTPDGHAHKATMLNSLGNAFFLQFKHLGELGDIEHAICFSHQAVNLTPDGHAYKATMLNNLGNAFESRFLCLRELGDIENSICFSFQAINLTPDGHGDKACQAVDLTPDGHAEKAGMLNGLGIAFSCRFEHLGELGDIENAIRLNHQAVNLTPDGHVDKAARLSSLGAALSCRFECLGELRDIENAIQLKRQAADLTPNGHADKAYWLSNLGDAFESRYFGLLRDIHNITRFHCQAIGLIPDGHADKAAMLNNLRKHLKDQGDIKNAILTFQQSTKNPSSPPSVQYCTACRWATLSSTHQDSFLALNAYKVILEIIPQLIWLGQTVHQCYKELPKIGRTINAAVATAISAGNLTQAYEWLEEGHGIVWGQLLQLQSLLDDLRDQHPQLAKDLERVSRALENAGTSTHSDVIDITNVHGSVTGKEEAQQHTRLAAEYEELIAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZI8</accession>
    <name>A0A8H5CZI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZI8"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034409919" description="Extracellular serine-rich protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="23061" checksum="39E39A30A75410A4" modified="2022-01-19" version="1">MYKLASISVLAFAGLASAQNVIDVQVGSTADAPGGIFQFIPNNITASKNDIVRFRFSGAPGNHSVTQSSLAKPCDNLANGFDSGWVLIPTAAAANPAPEWNLTITDDTKPLWFYCKQTQPAPHCGAGMVGAINANATAMTTFQNNAKGNTSPGQAVGALVGQGASASAPPGPLNNGASAFGIPSATAASGSGGSDSGAAPGPTTTGGSDNSGASTLYISGLAALFAAVMGITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0Y7</accession>
    <name>A0A8H5D0Y7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0Y7"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5350738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="35440" checksum="5CA58E40EBE1E846" modified="2022-01-19" version="1">MIQRDRLTRKPPPREHEDTHEMEQVGDGARNGVISSAPTSMQDFLVEITSLQSSISELKSNIRTISTYHSRSFQFNIRDEQTEGNGPSSAPDKTIAETRALMSTIKRRIQYLGDAIKTLAQNGIITKADADSRWDHLNNIRYKFMEAIQEYQGVEQEFNARSRDTVARQYKIVRPEATPEEVKEVISGNVNGQQIFAEATLASSSRYAETRAAYREVQECQEDIIKVERTIAELVQLYRDMAYLIEEQDVPITEAENHAIEVEENVVKGKEQTEKAVNSAHRARRMRIILFWLFVLVLLVVGLAVGLSVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1R0</accession>
    <name>A0A8H5D1R0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1R0"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="71"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5352037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="241" mass="27068" checksum="D93E177C41E5BB9A" modified="2022-01-19" version="1">MSPPRSPKVSNNMLNSSPTFQTVSPDNRMITWEQMEGLVNTLVKHRLESMRQRGQIIQDSQASSRMKPQFKRFGEWMPRVDIWDDPSSSSVIATFELPGVRREDLAVHVQDRRYLVVQGQRLCRLGNGLPIAAPTLPAQPATAADRVAAGETDESEQQGRFDRAELRYGKFSRKLDLGRGIYEFQNSHLTADLREGMLTVTWPRVPAGSEDISDNIPPIESLRTSHIGPDEGAHDDASPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D504</accession>
    <name>A0A8H5D504_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D504"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="254"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="632" mass="70805" checksum="AD1E98D2AE853F9E" modified="2022-01-19" version="1">MVQYAEMFAKAASNAVYKAGFDGVEVHGANGFIVDQFLQDVSNHRTDEYGGSVENRARFALEVIDAIVKAVGPRKTAIRLSPWNNIFGMGMDVPITKAQFSYLVSKIKEAHPTLSYIHLIEPRSKGDDVLDHDPEGESNDFIREIWTSPEEDENGRRVISSGGYTRELAIENADKRGDIIGFGRRFIANPDLPYRLEYNIPWNDYDRTTFYIQNTLDPKGYTDYPFAPGNPRSVANKHPLAAVYASQRTMSTSKLFQPLKVGDITLKHRVALAPLTRFRANEKHVPLSIVKEMYAQRASTPGTLLITEATFIDARAGGYPHVPGIWSDEQIAAWKEVASAVHAKGSFIYLQLYALGRTAYSAVLKAENPSYDLVSASDIPLSDYSKDEPRPRPLTVPEIKEYVELYAKAASNAVHKAGFDGVEIHNANGYLLDQFTQDVTNHRTDEYGGSVENRARFTLEVVDAVVKAVGPRKTGIRFSPWNTFQDMGMDSVSKSKAQFSYIVSKIKEAHPTFSYVHVVEPRAKALDVLDHNPEGEDNDFIREIWTSPEDDQNGRRLISAGGYTRELSIENADKRGDIIAFGRVFIANPDLPYRLEHNIPLTNYDRTTFYLQNSVDPKGYTDYPFAEGNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D666</accession>
    <name>A0A8H5D666_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D666"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5354407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33514" checksum="362052A6DF6FD05D" modified="2022-01-19" version="1">MTFTPVNSAEFVSIGKDIYLRPVDKAASITANSSGPEVILVFGWMGAKLPHIHKYTKKYEQLYPAATQILIRSEPSYFMSFPWTRRALLRPVVKTLQALGHVPSSPQSKLMPQPRILVHSFSNGGSLQMLALGQLLQSQGVTPELYQNAKVSSALIIDSCPGGESLSSAIKVFAQFFPNPLLRLPITAIMVFLYAIRVIRTGFFGTVPMFTRLKNALVEPSILPWFDENTPRLYVYSRTDELVPFDEVSAHVVRARGAGQNVREEVFDRSPHVAHARTDPVRYWSVVQELWTSAVKGPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D881</accession>
    <name>A0A8H5D881_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D881"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5354533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="470" mass="52687" checksum="E7A81C3CC771D59C" modified="2022-01-19" version="1">MTDARFWQSPEGHATLDAIVKKRVSLWSDGLKDEQRDVIGKILDGEKVLWLAATGIGKSATFFIPIIVHEEIRDNPSAYPGTKACKLPVGIVVTPTKGLAGNIVTEAQKLGITAFAYTHENTAKATRDGVDLVRVISKCEEYRLVCVDPEHLRMDEWKRIAASPTFRSNLLFSCTEEAHLIPEWGNPDFRPDFRFIGTFFRSRLPESISSFALSATLEPGKPTMFVCESLGFKEPFFHLIRGSNERPNTQFIVEPLTHGLSGDVFPQLLPYLSSGRKTIIHCQNLDTVYRVFVYLLSFLPNTPDSLRRMRVYHSMCSDKYNQQTLSLLENDDLCQIVIATVAFANGINVRTLLDSISLGISSSFNITWQEKGHVGRIIEFLCRGVLLVSPAMITKAHKYMEAYRKNAPLPSNMDLAIALVLTETICYIACINRIYANPPISESSQDCITAKRKLPCSLCVKRAGFQWVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D9Q2</accession>
    <name>A0A8H5D9Q2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="10">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="545"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="694"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="841"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="987"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1264"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1413"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1593"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5355246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1662" mass="188151" checksum="4D3FA53B41E0D270" modified="2022-01-19" version="1">MQMRRLWEPNTKPRYPSPNPFRPSSAFSNSFLAAMDTSKPIAFCEHLQLSSLGVQPASISFQTLTLESDHFICVREKVNEQNQVVIIDLADANNVLRRPISADSAIMHPHQKILALKAGRTLQIFNIETKQKVKSHVNNEDIVFWKWISDSTIGMVTESSVFHWSINDQATPAKIFDRHPTLAGTQIINYRASADEKWLVLIGISGNSNNPSAFKVKGSMQLFNRDRNVSQPIEGHAAAFAEMKLDGCQNTTKLFTFSVRTATGAKLHVVQIDHTAPDPPFAKKAVDVYFPPEATNDFPVAMQVSKRHGIVYLVTKFGFIHLYDLETGACVYMNRISGETIFVTAEHEATNGIIGVNRKGQVLSVNVDDQTIVPYILTTLNNTELAFKLASRANLPGADDLYMKQYQQLFQSGQYGEAAKVAANSPRGILRTVQVIESFKAAPTPPGGLSPILQYFGILLEKGELNHLESLELARPVLQQGRKAAVGEMAEGEQVIACFAETGQTEKITLYAKKVGYSPDYVALLQHIMRTNPDKGAEFAAQLVNDESGPLVDVERVVDIFMGQNMIQPATSFLLDALKENKPEQGPLQTKLLEMNLVHAPQVADAILGNEMFTHYDRPRVANLCEKAGLMQRALEHYEDLADIKRVIVHATTFPAEWLIKYFSRLTTDQSMACLQEMLRVNIRQNLQVVVQIATQYSDILGPVKLIEMFESFKTFEGLYYYLGSIVNLSTDPEVHFKYIQAATRTGQIREVERICRESNYYNPEKVKNFLKEAKLSDQLPLIIVCDRFDFVHDLVLYLYQNNLTKFIEVYVQRVNSVRTPQVIGGLLDVDCDETTIKSLLASVTGNFPIDELVHEVEQRNRLKLMLPWLEARVQAGSQDPAVFNAIAKIYIDSNNNPEQFLKENNLYEPLVVGKFCEARDPYLAYIAYAKGFCDEELISITNENSMYKQQARYLVKRRQPELWATVLSGENMHRRQVIDQIVAAALPECTDPDDVSVTVKAFLTADLPIELIELLEKIIIEPSPFSDNKNLQNLLLLTAIRADKGKVVGYINKLQNYDYGEIAKIATEHGLFEEALTIYKKYDQHAMAINSTDLRFGVGLAKAQLDGLRIKDSIDSYIKAEDPSNFSEVIEIANRAGKHDDLVRYLQMARKSLREPRIDTELAYAYAKTDRLHDMEDFLGMTNVADILEVGEKCFEDELYQAAKLLFTSINNWARLATTLIYLGENQAAVESARKAGNTQVWKQVHTACIEKQEFRLAQICGLNIIVHAEELGSLIAMYERHGYFEEVITLLEAGLSLERAHMGIFTELSILLSKYKPAKLMEHLKLFVARINVPKVIRATEKAHLWPELVFLYIKYDEFDNASLAMIERSADAWEHNQFKDVIVRVANVEIYYKALDFYFHEQPTLLTDLLSVLIPRIDHSRVVRMFKQIDHIPLIRSYLIAVQHLNIEAVNDAYNDLLIEEEDYKTLRDSIDSFDNFNNIGLAQRLEKHELLEFRRLAAHLYKKNSRWEESLALSKQDKLYKDAMVTAAASASTDVAEELLSYFVDIGNRECFAAMLYICFDLLRSDIVEELSWQHGLNDFYMPYKIQIQRSLVEKLRQLEKEVKEAATKNQQKEQAESEVPIINPGGFGNTLLLTNGFVGQAPPMNGIPPAMTGFGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D9R3</accession>
    <name>A0A8H5D9R3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D9R3"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="29586" checksum="9C54D9FF03EFD91E" modified="2022-01-19" version="1">MTSFTSTRLTQPSQARSRLPSSKHFSTSVTASADRPASNEKSPPPNGSPNIHPLRNTWVFWFRQQRAPGNKITNYEEGIKRISAFSSVESFWPLWTHLSPPSALQPTTDYLLFHQAIRRPVWEDPLNITGGKWIIRLKKGVADRIWEDLVLAMIGDQFDQCRSPEEGGDVSASWEDSSDQGSSELPEICGCTISVRQSEDIVSLWNRVDGDVKVRERIRDTIRKVLHLPPTTIMEYKSNNDSMQDNSSFRNSAIDRTPLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EW66</accession>
    <name>A0A8H5EW66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000512">
        <property type="protein sequence ID" value="KAF5314203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EW66"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034801181" evidence="3">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5314203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="348" mass="38376" checksum="F5D0CDB3C0EF5727" modified="2022-01-19" version="1">MTPLTACWLLFSLRCRGKVCKPYNSVLGEHFHAHWDVLPLIHNNEDPLIAQIYSSTSSVSVPALNSDAQRQSLIVSCTTNNVKGGSGPGGFRAVVEYKEESWLGKANFRIEGVIHTVPGSGSSPRASKDSSSADADTDSSSSLSEDDDDDVDDADENWEQWTKVKHVPPSHVVAVLEGSWRGEIRWKRVGSGSFTYSGNKSTNTTQHNQHAYTAPSSPNPSHTALPNPSKHPKSNIAESKGDLSLPGTTQDSKDSKGGTKGTMGTGKDKDKAKGEEEWNMLIDLSTLFPVPKQVRPLDRQEKYECRKLWEGVTSRLLKEEFSEATKEKVVIEQRQRDEAGERRRKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F0F5</accession>
    <name>A0A8H5F0F5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000441">
        <property type="protein sequence ID" value="KAF5318972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F0F5"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5318972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="477" mass="53608" checksum="543C39C98E4B1169" modified="2022-01-19" version="1">MIPSIITYSFPSFVHFVSAPYFYYAVYNTQRLTDVELPDWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTSQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLAQFNNYLHMNKGKYPTEESQVSLFLSFFTGEKGGDWAMQRLTERDADEENEELTTTPNQWRWITLKQIRDRFKKDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWNDFDEYKERAVELHLEWLKERERQGRWKTTSTSKSSSGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPKTLSQNTSRTFPSRTIRTAETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F469</accession>
    <name>A0A8H5F469_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000402">
        <property type="protein sequence ID" value="KAF5322947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F469"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5322947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23388" checksum="2D64F39CFE34742B" modified="2022-01-19" version="1">MIERFPFLAVGYVTPTFFATPFEENLNLSKAVLGYENFGYWDFFSSEGADQTILDHLDSFWDIVYTKDTTKMITDWSPLGALEAFITNGTRISPVDYVTPEERAIQMEAIRQGGLAAPLSWYKIARGTLEGQDDQGIPPENALIHSPVFFGAALRDYVLVSAPSFLAGALVSSNSTATIREYNSGHWVQMAFPDEVNGDLLEWIEGLGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4G9</accession>
    <name>A0A8H5F4G9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000402">
        <property type="protein sequence ID" value="KAF5322948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4G9"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5322948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="664" mass="73713" checksum="9339F60FD654641E" modified="2022-01-19" version="1">MSKILLDVYSWLKKELQIPSKAVDARRLTTDTVTGSDALFSRALIIGIDHYVDPTIPDLENSVVDAYAFKQLLCSRGVQEKHIVVLCNESASCARIEEEVQTLTNSDAPVFMYFAGHGATGTLSSKSRFFGRASKADNVKMLIPHDFGLEGPRRGVLIQTLLSGLSERSVLFTDCCYPLQSPTLASVGRVRGISLPKTSLVTGTLSFAKNNNAPLPFRFFSWFLHLFRLIVGRKRQTSSCIFLSACRDGELAKESTDHGVFTEGLLRRLWCGNASQLTYESLSVLTSIAEQNALCEGSLRSSQLEFGGRSRLLDHEREHCFAWPASTPGECLLSVGHSLGVSPGAQFDLFADAPHSEYIGRLTVWQTSSFSSVARLSSSPPGINHMNWTLRYALRLQGDLRGGLRVLLSSTPLLRDQILESITPEIGLVDRDPDLVIACDSDRGVANLELFLPSIEGGFKIPFPVSASLDTLLYLLRSAEAFLWHIRTHGRHGPIAANVVLECRRLVATSNKTDLFRSGWIPESNTNLINDAGLLDAEVGQKYGFMVTNHSTVNIFCALLYFDLSDWSITLYYQTRFNEPLTPGGSGTFGYGQNFRDRPVVYFLREGQKVDYGFLKLLISTEYIDYFNLTQPPVLGQTPQIPVEFINKSRSMASNYILIQTIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4P7</accession>
    <name>A0A8H5F4P7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000397">
        <property type="protein sequence ID" value="KAF5323188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4P7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11937" checksum="8DDCC038C18E009B" modified="2022-01-19" version="1">MWALFYFQTGHAATYCQSLIDHGHLYSSSHFDTWREFETEFIKEFMPEDEHTQASLTLEGVSYFQGTASVDKYVNNFRALITMAGLNVEPILYSTDPTEPTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC15</accession>
    <name>A0A8H5FC15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000329">
        <property type="protein sequence ID" value="KAF5331286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC15"/>
    <dbReference type="OrthoDB" id="2685413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="4">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5331286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="300" mass="33767" checksum="702703D1E577126D" modified="2022-01-19" version="1">MHTRTSFTVIDPHTVSPGHFWIHINTTISGGSSMVGMVNIEDTTIDRDVFPSIADFLRDRKELKTPRLTVGDSFNHQHSTYTFLASLGFDSCIWGVLPTLTGLKGLGMTYLRSWSLTLSNMTFHSHTHPHYRAIPCNWSGPPTSESVNPHSRSTSGVGSMSSASVTLGRNAELMIFLPLYPITLGHTDVQKVEIDSFSGFRIYPSKGKLFVRGNSKIFRFSTSKTASLFHQRKNPHKIAWTQVYRRMHKKGITEEVAKKHSRRTVKHQRGIVGADLAAIAAKRKGWVCERLLEDFDWHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDF1</accession>
    <name>A0A8H5FDF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000291">
        <property type="protein sequence ID" value="KAF5333040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDF1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="87359" checksum="AD078BCDFB718590" modified="2022-01-19" version="1">MRLSNSDIHFATPPPPKIFTGRDDLVNEGVEIPCRRGQHHLAILGPGGIGKTSLALVISNQPEVQAKFPRFHFLPCDILEDQNGLIQGLIQVLGLKMQEGKSQHDILYDYLQINHNPLLFILDNFETPWNYKDARTDVKHFIEKIADFSCVTLIVTMRGMEGPGDIAWQILGESQIPTLSMEAAREAFYQVSRKIKTEDNSGKIDHLNEQLDCVPLAIRLIAQLAKKISLENLLRRWNELKTKILSESGAQPGKLTNVEFSIELSVRLLDPAAKDLLGALSYLPNGVPNWNQTLSEMLPDVPEPEIKVLQLLDCSLVLEKSEALMMLAPVREYIAARYSISDFFRNQIEIFYVGITELISSNSKPGQDFELHTLNLFKTFSQYQGQGGQEKAALCLQTLGDKYYHVDQYSNAAKFLTEARVKFQNINNEYEAANCLWLMGDIHRVQSRYNEAIAILAEAKSCFEQIRSEEGIAGCLWSLGDIYQMQDKYNEATAALSEARVLFQSIGNQGGAANCLMSQGDIYRMQSKYSEATETLLEARVLYQSVGSQLGTANCLSSLGNIYRMQGKYSEARETLSEARDLFQSIGGQRGTAYCLWNLGDIYRQQSKYNEARETLSEARVVYQSIGDQRGTADCLRTLGQTLEDQNQLDEALSLIHEAYAIYSTINDVRDMGHCLEKSGVIYRKMGQYELAKQAFINALGVFSQLQSTDHYYMGWCLYEFGFLFKDMGEYTEVRKKFQEARDLFASHGELQRYVPMCERALKEMESLAEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDL1</accession>
    <name>A0A8H5FDL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000301">
        <property type="protein sequence ID" value="KAF5332891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDL1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="111"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="487"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="659"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="790"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="833"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="919"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="962"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5332891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1088" mass="121567" checksum="54D18B7DC05405F2" modified="2022-01-19" version="1">MGTSEDGNDLQQGNTIGHHTGEQTTVVTQNMFPNASNLTMTGVTISNVGRDFIQTTNNNFGANEKAEILKELKQKLNPIAKPARKTDTCLEGTRVKILNDLCNWVIDANTTIAWIYGIAGTGKSAIAVSLARKIRKIDTKKEVKLALTFHCVKGQETSHICNLVPTLSYHLAQVFPEYGKGLLESLNRDPSLDGTSLSLSEQLELFLDLPVLEKLIIKSSEKVVIIIIDGLDEWGTGLNRRELLRHLKTLNQFAWLKIIVTSRPNPEITEELIVELFIKKIDLSDHIGTADDLRKLITSKLSWVSNEKMDNMLAKANGLFIWVTTALTFIEMGVDKAGRLEIILNLKKGTYDELQPYEPLYHLYKTVLTESFSQQDNLKYLTVVVGAILAVIEPVSQDTLKNLLCAKGVDVPTRVTEEVINQLRALVYDRDGKLYYHLSFGEFLTSSENKLNIHPKFTHLQLAMSGSEDYTIRIWDIQTGQQVGESLEGHRDEVISVAFSPDGRHVVSGSNDNTVRIWDVQTGQQFGEPLKGHTERVLPVAYSLDGRHVVSGSGDNTVRIWDVQTGHQFRESFVGHTGTVLSVAFSPDGKHVVSGSADTTVRMWYMQTCQQVGEPLEGHTDWVRSVAFSPDGRHVMSGSDDKTLKIWDIQTCQQVGEPLEGHTGWVWSLAFSPDGRHVVSGSEDYTIRIWGIQTFQQFEEPQQLSNHTDAINSVAFSPDGRHVVSGSADKTIRIWDMQTCQQVGEPLEGHTDWVRSVAFSPDGRHVVSGSADRTIRIWDMQTCQQVGKPLKGHTDWVRSVAFSTDGRHVVSGSADKTIRIWDMQTCKQVGKPLEGHTNEVSSVAFSPDGRHVVSGSKDRTIRIWDMQTCQQVGEPLEGHTDWVRSVAFSPDGRHVVSGSDDMTIRIWDMQTCQQVGEPLEGHTNWVWSVAFSPDGRHVVSGSDDRTIRIWDMQTCQQIGEPLEGHTDYVRSVAFSPDGRHVVSGSRDRTVRIWNIDPSNPNLIPASISQYNQENQSCSINDQGWLCTAEPEPKLILWIPPHLRGFNDLRQVGTIPADAENFAVKVDWSKFVCGEAWTSVWNDNPEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FET0</accession>
    <name>A0A8H5FET0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000267">
        <property type="protein sequence ID" value="KAF5334139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FET0"/>
    <dbReference type="OrthoDB" id="3112770at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="15221" checksum="25A74D4B6DFF8AE2" modified="2022-01-19" version="1">MVFLVFRDWVDRPVSARVKRDAWVYILSFRNGKACKIGCTRRTPRHRLQEWRCKDSRRDSNWYISVRVSEERMFGIEHEAHQQVLKYTHKSNGACLNCSSKHQEEFVFKAAFGLRDACDAVDRARELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJU8</accession>
    <name>A0A8H5FJU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJU8"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5339267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="773" mass="88501" checksum="D6ECD873EB4A4D57" modified="2022-01-19" version="1">MAPALTHPTGVTFVPDHDITKPVSDPAQYYGGGDSFTRSRTYSHSHIHSYDVKRAPAFQDDTHGRSRRLSHDEKSVTAPRRFLIDVEETIRVVLEQEDTDGDFQISVTDAGPKMMALGTATSNGFKTFDIRGTYMLSNLLQELALARDHGRKRIVLDEARLTENPVDRLSRMIKNSFWHSLTRRIDGEGLEIITADPKNRTGRVNPRIYVPYGEPEMAEYYRNVAKEKPHMNLDVQVLPQKPDDPTFVKSLNSKPGILALAMNKVDDGRGGKTLKGIPFIVPGARFNELYNWDSYFISLGLLVDGQVNMAKGMVDHFIFEIKHYGKILNGSRSYYLCRTQPPFLTDMALQIYNQLDRSDVDENRRWLKRAIQAAIKEYHTIWVAEPRMDPKTGLSRYRPDGLGIPPETEATHFTHILEPFAAKHGLSVLEFSEKYNNGVLKEPDLDEYFLHDRAVRESGHDTTYRFEKRCANLATIDLQSLLYKYEVDIGTAIREVFDDELELEEDFDLAPFPPTSETYANPHRERSKSRPQTSAEWFERAEYRNQQIDKYLWNESKSLYFDYDTAKEQQILYESVTALWPLWAGCASEEQCWKLVSQSLKKFEVLGGLVSGTEESRGKISLDRPNRQWDYPYAWPPHQIMAWVGLERYGYLDEAQRLAYRFLYMMTTAFVDFNGVVPEKFDAVKLSHLVDAEYGNQGIDFKMVPREGFGWMNAAYQVGLSFLNTHMRRAVAACTSPEVFFQSYNSAVLSPNETSRAVDALGLAMDSLEITTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKM6</accession>
    <name>A0A8H5FKM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKM6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="12170" checksum="172B9555A4FA3ACB" modified="2022-01-19" version="1">MQYRGKGQLRLRMMKTKTWLVSRWVGSNCATEIEQHSNLEMLSGIGVMQTEILELYKVNSLTINLRLDEDTFDLLLGHASVVKIGVQTSPFPDAVDGSRTFKAAAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKS0</accession>
    <name>A0A8H5FKS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKS0"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="67095" checksum="AD76C80272249C28" modified="2022-01-19" version="1">MCAYSDHIPLPPIDISRFGEPCPSDPEVRQIRQQIEYAEHHLNQDDQEMDLVVEKRNDVIRRRLKDYYAFISPIRKVPFELWSEIFALAIFSLPGCCSLQITYEDITAPVLELSHVCSLWRAAAISTPVLWSNMDVNLADVTRIEKIVHLYLRRSEGSLLQLKLCALDDFDNGIEALTPCGWHVFEMLLEVSNRWSHAAFEFWWELLDDKKIEDKLKTLSWNCEFLQSFNVDFNGDIPENAEDAAQSPRLFQLLKRAPRLQILGLAPLRKWFLLPFAQLQDLASISRVDDVLSCFTMCSNLQKLDLVIINFSRRTLPDTRRIEHTKLRSLTWRLHSSHGPDIHSLLFLPSLTELAFSTPVDYKLQDAPRLCSSIQDFLRTHSKCQLKSLKLGAGFYISDEDLLQMLSLIPTITHLELSSCEFRGFMPPFFKGLTLRIADTGNDSAGILLPRLTNLHISIDERIGYGILWKPIPLQWSNGFPFPHPNDILSMLESRRKSVEDSQGQTSLLESFNLEVYLNRVRDDCSVKDWTTVWFGQKLGSHLKTLATEGLKLKLRISSFKFERNNENDINVVTDEEDHIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN28</accession>
    <name>A0A8H5FN28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN28"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5342821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="148" mass="17050" checksum="FE8B6A2E93B0E1C8" modified="2022-01-19" version="1">MPIAMVLRIIKGRNPEDSKDGMLVFENPPDSVAWGRFRIYSERVREFVLDFRNYLPLLETMVGIRPASSLILFPKLCRLKVIVEDEYPGCVEILVEFFHQQVDSFIYEIHEYDETKTSKTSRLISLFTSIFKGAGNLPFNLTLTQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN32</accession>
    <name>A0A8H5FN32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_013434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN32"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223621" description="RING-type E3 ubiquitin transferase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5343255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="465" mass="51299" checksum="D85DE40183ADDDA2" modified="2022-01-19" version="1">MRSLRVYCNLLSLSFLIFPQVYSRELLVERLFRTDSEKTWWNWAWGAESTVSVVDRTPPISFSSRPAAFGAEINGPLLGYVIPLSSFTIPCSNDSLVHNSSNAGCPTLCLSGPHSPDASELWIALVQRGQCEFVSKVREAQRLGARAVVVGGSDPEISGYPDTLVNMYSPEDASDVNIAATFIKYSDYDQLFSLIKASNTSHAGLRTLSLLITAEYSAWEWYSPIITFIVILLLPSILTFITLLIHRIRAARAAQRDRAPEDVVHNLPWRVWTGTGWEKHEGACPQQQSSSSTPAAPDANLVDLEQGLSGSPDDADADAAMIDADEPESSYHPSTSKPTQPDQPWFECQTECAICLSEFEKGDKVRVLPCHHIFHMDEVDAWLIQRKKLCPVCKADVTNPNPFAQHHSDPDHDDTHGDSDEASPTPQDTQSHPPSRPTTTEDATERTPLLSNDRGLSSDSIDGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPD2</accession>
    <name>A0A8H5FPD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPD2"/>
    <dbReference type="OrthoDB" id="3131783at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="354" mass="37028" checksum="D88D4CDC4F51FFD6" modified="2022-01-19" version="1">MLMFTATEGPGPMPSTSMDTEHNISVWRNGVADADSNSTSTSITAMTTSTSASASTSAKSYYPVLALDIGSGRPSCRSFPSSSNNNNKNNNASTPASTSYSSSSFNPKQANLECSWSTSSLTSEASLVPTEIDIPPINWDDPTEAKDEGLGLGILRILPKAKEVMPSIMEMEVEGGEAGADTNAATNPNLNAESTSTPRNRSWRLRRMDTENQTFTLADDGEAEALGSASATSASASTFTSTTTTSSSVSATQASSASTSASSTASSSSASTTTTATSSSTSSAPTLLPNPIHAPHHRLNHTPPAPSESFPSQAPSPPVSSLSNSSIHLRLKRRGWILIELRWGIFEGFGRSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ13</accession>
    <name>A0A8H5FQ13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ13"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="111"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5344906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="399" mass="43480" checksum="8C2337DF26E3E2F0" modified="2022-01-19" version="1">MSNLYRSALSARIAKLPVEPPHFDGEDNEEDEEADSLGSLPGSGMGPPAMPAMTRRPTKPKRDPNPEFSPISASSFFVEAVQVAVASRKLDCRVYYTPPKFANGTVMICQHGAGFSGLSFACMAKEIADLSKGECGVMALDARRHGKTTSSEPDDDLSIDVLVADFVEVVSAVFTDVASTPSLLVCGFFPALQSTHLIWTTKLIGHSMGGSIITRACPILMEMKYKIAGVAVLDVVEGSALDALPHMNSLLNARPDGFDSIEEAVEWHVTTKAIRNPTSARVAVPAIVKPSESTSPVIPPIIWRTPLRSTAPYWRSWFEGLSKMFLSARTARLLVLAGTDRLDKELMIGQMQGKFQMEVVPGTGHMLHEDDPTRLAEILVEFWRRNERLTVGIKKVGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ50</accession>
    <name>A0A8H5FQ50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ50"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="435" mass="47488" checksum="173ACD3DE8C0386B" modified="2022-01-19" version="1">MATEGLPPLQPLFTRNSKRTRAVFASCPDDSITDEERSVRMRLSVKIRDEYNDFRELPPALLAQQGPVGPARPKENRKMITAGPSDSTSALISKIDNTPTPQPSTFTSNSRLSQALTLHKTTRTVKPVYHPPWKLVRVISGHLGWVRSVAVEPGNKWFATGAGDRVIKIWDLASGELKLSLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLEANKVIRHYHGHLSGVYALSLHPTLDVLVTSGRDASARVWDMRTKAQIHALAGHTGTVADVKCQESDPQVITGSMDSTVRLWDLAAGKTMVTLTHHKKSVRALAIHPTEYSFASGSAGGNNIKKWKCPEGNFVFNFSGHNAIINTLSVNAEGVFFSGGDNGTLTFWDYATGTPFQNLDDIPQPGSLEAEAGVFCSTFDHTGTRLITGGADKTIKVYAEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQA6</accession>
    <name>A0A8H5FQA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQA6"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="89" mass="10452" checksum="25E9A488870FF7D6" modified="2022-01-19" version="1">MRHNRTGISNIEEEIISKENDRFVIHDSQGYEPGDPTKFQELQRFIEQRSGEAKPSDKIHIICVVFFIGFALRLFMPEVEFLRQARNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRF6</accession>
    <name>A0A8H5FRF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRF6"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="15623" checksum="A0687AE618D927ED" modified="2022-01-19" version="1">MYASSILNLIITFSLDVDHKTSAMAWEGLSDPECGHSSELTKTVFGRAMNTNLSYWDFLALPEQQHRHHIFGFLMQGIAAMQPPNMIFKALDWSSVSSNAKVVDVGGGIGTATMSLLEKYPDLTVVVQDLPHVVEEGRKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT29</accession>
    <name>A0A8H5FT29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT29"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034107686" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16858" checksum="5D8EACF915923621" modified="2022-01-19" version="1">MQRFRFLLFVLLSTLSLILAVASILRICRDQLTFRNCLTSWPREGSKFPSLFSIMPTVNATRVLKTTATKTSRTSSSDAHIEWSVHPASFVAPHEATPTVYSSSPRKGRSGTQQNGHNHLMERGESKATRQTCKAEGANGDEDDRCPWAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUM5</accession>
    <name>A0A8H5FUM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUM5"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5349332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="422" mass="48368" checksum="7A3F1ACEC6EF133E" modified="2022-01-19" version="1">MSSSEQSFKISIPDSALESLQKKLALATFPDELELDSDEERRKYGAPLAHVQRLVERWKTRTPDIANGSGMATDKEGFDWRRAEAKLNEDLSPMFTRDIEVEGFGTLNLHYVHRKSVKEVDGKGRKPVPLLFVHGWPGSVIEVRKILPLLTNPENEDDLPFHVVAPSLPGFGFSEAPKKKGFNLTQYAEIFNKLMLALGYNEYVTQGGDWGFYITRRMAQLYGHTHIKAWHTNYPGPGALEPTFTTQPLHYLQHLFTPYTATEKAALERSKWFSTQGMGYNIEQSTQPQTLGYSLADSPVGLLAWIYEKLVNWTDGYKWDDDEVLEWMSIYWLSRAGPAASLRIYYEVTQANQRQIPAREKPTIPMGWSRFPQELRSFPRTWTENVGNLVFDSEHPSGGHFAAHEEPEKLVGDLRRMFEKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV35</accession>
    <name>A0A8H5FV35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV35"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="38443" checksum="AF8BCAE15A913621" modified="2022-01-19" version="1">MSMSTFSMPGPMLPMATSMPIYSDVSGNDYLGSDSSELLISMRDVDGPEPDPPELSYGLITLASPNPDPLAPSFSALSSPLPSSPLPSSSPSFSFSFSSLPPPLASPYPSISSLRSPSSPSSSPSWPPSSFHPPPDSEAIEKSSVLGSVMLLQIIGWAFCIWTVRKKVQCNHMSDEEALRRNLAPDPYILIQCPNGNSDSELDGSTKRTRVKRTRSKLTKKISRRAPRAISLPGAGGSASHSHSVGEAENKRYSTEGTGVPNWAADVSGTSADHATPSPSSPSFQQRGLTDVYPDHPSSSATTSTSAIVPGSSECHSVNLAVELEEMEGRVEHLEKRVDIIDSPPRYESSVADARSLGTVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWF7</accession>
    <name>A0A8H5FWF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWF7"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5351298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="29215" checksum="2D3E0832B2277B1C" modified="2022-01-19" version="1">MPTSTSGNNVNDIEKGPIQHLENSHSTHYRPPIQLSPEQYEQLFLQPRDRAPSSLTIRFGNPTAIGIISHLLSLTPTAAYLMRWGGADATSLVTMVGPYYFIGGLGLVLSGVMEWVLGNSFPSVVFISFGGFWLSLGTLNDPEHNIAGAYANGSAALAYNDGLMFYFAFWAVTCTVYFIVSLRTNVVFAIIFASLIFTFVCLAVGYARIGDGNTDSAFDWLKAAGACAWVCICAAWYLIVSLLFAAVEMPYTLPLGDFSGRVFRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0E0</accession>
    <name>A0A8H5G0E0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0E0"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5355467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48470" checksum="678731246D87AB8E" modified="2022-01-19" version="1">MSPLVFAHFMVGNTYPYSIKDWAEDIDLALKSNLDGFVLNVGKERWQLDRVSDCFEAASRAGCNIKFFLSFDMSSIPAKTESDIQLLAGYLEKFANSDKMLHISDKVVVSTFAGENSLFGQSSLDSAWLWVKRVLRDTVGIEIHYLPSLFIDPEQYTQLSCLDGVFHWNGAWPVHLGSGSSPGEKVFPKLDSDLKHISHLNGRPYTYMASVSPWFFTHYGADSWNKNWIYRGDDWLLVKRWEFLIENRHKIDIVQVISWNDYGESHYIGPVKGAQPNSEAWVNGFPHEAWLHLNSHYIRAFKEGTRHPIIEKDMIFMWARPHPRDAQALEDPLPRPNNWQLADDDLRVVILAKDHAGVVVTAGDTDKQFRIYKGVNLLSMPLQTGGGMSAKMYRETVLVAECSASGYRFEANPKTYNFNAFTAMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2W4</accession>
    <name>A0A8H5G2W4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 12 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2W4"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22587" checksum="5728337133DB4565" modified="2022-01-19" version="1">MFMVGIVFRRQSGVGSQSSTLTSSNGNNIAWTTNYTWANGPNSVKSYANVESSVAKGVQLSAIRSAPTIWTWHYGTQSQGIRADVAYDIWTGVARSGAPASSASSYEIMIWLSGLGGIQPVGSPVAQGISVAGHTWDLWRGPNTNWQVLSFKNVGADITNFNVDLNQFFQYLIQNQGVSSSQFIQSIQAGSEPFTGTANLVTSNYSVSIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G587</accession>
    <name>A0A8H5G587_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G587"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712530" evidence="2">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="183" mass="18757" checksum="0E865861829E2322" modified="2022-01-19" version="1">MQFLSLSLVFLPLLVQGIPQRSPPPTTTPTVAPTTVAPTTVPPTTVAPTTVPPTTVPSPTTSATVAPTSTAAPEPEPPVFEVVFSNLTGAINAPGFLTFALVQTVDDCEAFCNGVAGCVFLNAFNDVNGKDNSTLLTCSVYDTCHNATEATNTGGQTQPDGTVDFIKDSTGECKVVSGTAPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5T3</accession>
    <name>A0A8H5G5T3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5T3"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5358901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="184" mass="20955" checksum="D2DF11B4802DC8B9" modified="2022-01-19" version="1">MSLPPSLRTSVTPTELELIATQQLIEIIPLIAMEKTAFISGAYGPLRPPHRAKIPIWMAVNLKLKKKCHILPPYWLNVEFLQARLNEETSEAGFSRLPFRFAEVAKVLLDVAPDDIQDTEKIRSILKDLREARQAKSREGLANLDRGEFSLPNFCSLEINEVRPFFVRSMAILQQLYREPSDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Z6</accession>
    <name>A0A8H5G7Z6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Z6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="147"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="27208" checksum="B9F473D558E2BEA1" modified="2022-01-19" version="1">MASLQIFSQAFIRASILEFFSLDLLLQLLNTSESDSDSTHTALAPPPTVPQDSSSRLPRVRASNLPRSLLPSKAEIPLHLLNSHHNTPHDLHPLLRLLPLPLITLLELHMLRHPHLASLTVNILMANSVLFQDDIAKIMWALSYFQTGHAATYCQSLIDHDHLYGSSRFDTWEEFEKEFIREFMPEDERTQASLTLEGVSYFQGTASVDEYVNNFCALITMAGLNVEPVLYSMNPTAPTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH92</accession>
    <name>A0A8H5GH92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_009338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH92"/>
    <dbReference type="OrthoDB" id="3039857at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5364803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="14310" checksum="E227F87A597FB14D" modified="2022-01-19" version="1">MVVIYRNILESAQAIIEAMLNIGLLHSNQAAVDKISDCVVSEDIPIILSSELTNAIHQFWTDPTIERVIDEHGSEFYLMDNATYFFAEIRRISSQDYIPTETDVLNARHKTTKITETQFPLRDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHM1</accession>
    <name>A0A8H5GHM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHM1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5365206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="454" mass="50116" checksum="E2A82EABF4457BF8" modified="2022-01-19" version="1">MASNTSTRTEIEALLQFIHSSTEEAMSEYEKTGHGIPTSDSTVSHPLDNKPGALALRKAIRTLEAACEQLCTTLAQPMHTLVNRAMPYEAPCLKFVAEERIADILEASPNGVKGMHIDDIATSTQNKFASDKVGQVMLLLSTRGCFREVSKDVYANNRISLSLLSTNPISSTIALLSGELLQGVTMLHEAMVHPEYAFSRAGNRTGYSYLLRNEMPNASYFDWINANRFQRSMVGFSQISGSSEAVLQVYPWDSALSSRKDFLTFCDVGSGPGAVALSLSKFYTDKFRVTLQDLSEPLEQAKTVWSVEYPKADVAFVPMDFLKESPVAGQDFYFLSHIVHDWPDSDAVTILTNVAKAMSDTSRAILHEVVLEHVQGEPDEEGLGSNEKANPPLLPNYGSGNVRPYNYNIVRCVSKSQFPSLEDDAQIPYHPLAHARNGTFNNGERTRETFILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHS3</accession>
    <name>A0A8H5GHS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_010977</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHS3"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034394457" description="laccase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="169"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="370"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5365088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="528" mass="57108" checksum="1D4C767E755D71FB" modified="2022-01-19" version="1">MSRKMSLRSFKPLLLLALASSSFAETIGPVTDLTISNAEVSPDGFSRTATLAGSTSSVIGPLIVGNKGDNFQINVINQLDDDTMLKTTSVHWHGLFQAGTGWADGPAFVNQCPIASGNQFLYNFFATDQAGTFWYHSHLSTQYCDGLRGPLVIYDPDDPYADSYDVDDETTVITLADWYHDKAETLTFPASDATLINGLGRFDGGNATELAVITVEQGKRYRFRLINVACDPNFVFSIDNHTMTVIEVDGVNHEELEVDQIQIFAGQRYSVILNADQATDNYWIRANPSTGTTGFSGGINSAILRYVDADEDSEPGTPEVTATNALVEEDLVPLENPGAPGDPEVGGVDVALNLDLTFTGTFQINDVSFVPPTVPVLLQILSGAQTADSLLPSGSLYSLPLNSTVEISIPGGVAGAPHPFHVLHGHTFDVVRSAGSSTYNYANPPRRDVVSTGVTGDNVTIRFTTDNAGPWFLHCHIDWHLEAGLAIVFAEGTDSWNSTITPTDQWDQLCPTYDALTSDELRKRSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI64</accession>
    <name>A0A8H5GI64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI64"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="158"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="302" mass="32870" checksum="0F1D2D78A86D7D30" modified="2022-01-19" version="1">MTLSPFRSLTFGTSPSLTGISARSPARARSCRPPSAASNSAMDATQINLHKVIGPMLIGAWLNLMLFVLVINQSHGLGIISDDLDSRSSRYHIDKILIKIAVFAVLVCDMGTIIAGCADAYLLASTLYLTTIVILFQSQGNLLPTQILPATILWLSTAMVADLLIALLMILYYRATDVDRTLKSSSKLIRRLAILALKTGSFTALIAVLTLVTFVTDIQSNVTMIFGYCIGSIYSLTLLYNLNIRRKLVNRTNPGDVLDIRVPDLESRTRVTKPVASNGGDILNVESRSQRGRFVIAASIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKX4</accession>
    <name>A0A8H5GKX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKX4"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8567" checksum="DACD575BBE6FEC70" modified="2022-01-19" version="1">MKTADEKGDLIVFGRQFISNPDLPFRLLNDIPLTKYDRSLFYCPGDNNGKRYIDYPFSVEFLNQKKLEMTSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL41</accession>
    <name>A0A8H5GL41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase UstS-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL41"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="143" mass="16263" checksum="0ADEB087B1DCE711" modified="2022-01-19" version="1">MPSNTRALQLAFEEAVPANIGPMFQFILIKLCDVVNPASKEYFRRTRISLFGKSVEDLVPKGKSAKVEWKKLEDGFGKIAGWMKEDKFIMGDTASFADFVIGGFLIMSKIAWGEDSQEWKDIAGWQDGRWSKLVKNLEPYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLJ0</accession>
    <name>A0A8H5GLJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLJ0"/>
    <dbReference type="OrthoDB" id="2552152at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36122" checksum="C877D91B932FF88F" modified="2022-01-19" version="1">MFLGFVPGPSMSSSKRGRKRNDTLPPNRARDVQRAFRARRAAHLQALEQRVSDLEEENTYLRQALNLPPANRPPLGKGPTGKDKAKPFDTSPAPPLSLRSRESSSADSPDSTRVSSHSPSQVSGLPSSHVDDVSGSQWDQPILLHEHPQSDMSSSSASSSYPLPPLNIPAIPSKPVQYNPYPSSIPSTSRSPVYMNSSQTDYPHSADRPMTSTYNSPTFTLRNSVRTSDDARTYYSYASHDDHLHASAAVISAPLHTHHRDTSLPYPSRRAMTDPQSTYTSDFTHIHLPSPHSIRLPSPPQGLQDGRGTSSGHIASRHTYETDGRVSGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM34</accession>
    <name>A0A8H5GM34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM34"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="43228" checksum="290E2A472E75E6F9" modified="2022-01-19" version="1">MSDKAAHLQNYAKTDEISPLGRYRLLSPLASIRVSPIQLGAMSIGTEWSAGMGEMTKESSFKLMDAYYEAGGNFIDTAINYQNNTSEQLIGEWMELRGNRDEMYTSPWKKHDTSVRQKINFMGNGPKNLTLSLNASLKHLRTTYIDIYYVHWYDFETSIEELMNSLHNLVVSGKVLHLGISDTAAWVVARANQYAIDHGKTPFCIYQGQWNLTKRSFERDIIPMARELGLALAPWDVLGGGRFRTDAEEEARRQNPQGARTGFTQDGKWERNEEEKIISQALEKVAGEVGAKNIQAVAIAYHLQKTPYVFPVLGGRRVENLHKNIEALTISLSKEQITYLESVLPFDPGFPHWMVGDGTKPILMISNSASVDKWPVKEAIRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMY8</accession>
    <name>A0A8H5GMY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EML-like second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMY8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="151"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="571"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="641" mass="69079" checksum="2EE5AB6EB1418A8A" modified="2022-01-19" version="1">MNLLTGKHIQELQAHTDVVTSVVFSSDGTKLASGSADDTLRLWDVVTGTQITEPLEGHTNEVRSVAFSPDGTKVASGSWDHTLRLWDVATGTQITGPLQGHTCDVTSVVFSPDGTKLASGSCDHTLRLWNVATGTQITEPLQGHTDWVTSVAFSPDGTKLASGSQDHTLRLWNVATSTQITEPLQGHMDCVESVAFSPDGTKLASGSDDHTLRLWNVTTGTQITEPLKGHTDWVRSVAFSPDGTKLASGSDDHTLRLWNVTTGTQITEPLQGHTNCVESVAFSPDGTKLASGSFNHTLRLWDVATGTQITEPLQGHSHMVNSVAFSPDGTKLASGSEDHTLRLWDVATSTQITEPLQGHTHSVASVAFSPDGTKLASGSWDCTLMLWDVATGTQITEPLQGHRNLVQSVAFSPDGTKLASGSWDHTLRLWNVTTGTQITEPLEGHTGQVHSVAFSPDGTKLASGSFDHTLRLWDVATGTQITEPLQGHTNCVESVAFSPDGTKLASGSWDHTLRLWDVVTGTQITEPLQGHTHYVNTVAFSPDGTKLASGSWDHTLRLWNVTTGTQITEPLQGHTDRVISVAFSPDGTKLASSSRDKTIRIWNIATCIQNLCYYRNDKASFFFSHFCRNSILINIIGAAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNJ6</accession>
    <name>A0A8H5GNJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_002441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNJ6"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="124"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5368359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50455" checksum="9C35B8A344B10F69" modified="2022-01-19" version="1">MVIDGKPALPNSSSSTPPTPELTDTVVHYQKFIPNDDIEAQFEVTERNSESTSVLPADPFHFRNALKSSAELDAIRRRRKGRRLAKYHARQNNLIGSLLKSIEEHTSEARVEEEAARLPVKIAVWASLIANFSLCVLQMYAAISALSLSLLATGIDSIFDIGSNLLLFWLHTKAEKLNEEKWPVGGARLETIGNVVYGSLMGSVNLVVIVESARSLITHYRDADDVLNNFHLPSIIAVASALFVKLLLFLYCYSLRKNSSQVRVLWEDHRNDLWINTFGILMSTGGSKLRWCMYSIRLLRAFFPLPITAPNSKDTCELSVRSFNLDPMGAIIIALGVIVAWGRTIYGEFELLAGKAAPHDMLQLLIYKSMTYSEEIEKIDTVRAYHSGPDYFVEIDIVMDAKTPLWKAHDLSQKLQDQIEELPNVERAFVHVDYETTHMPEHRKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPF2</accession>
    <name>A0A8H5GPF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S5 DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPF2"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="531" mass="59713" checksum="41D025C778005881" modified="2022-01-19" version="1">MQRLARQFYASSRIFCRQNAVVNRHVSRRHYAVVPSLFQLPEGLAEGRYAQFYRLIRPDLSVYELARVAAALITNAKDDIQAQRVYLLLENNYPDLDQQKLLEQVNRFVQNPPPDNFDYLLSALPTEESGRPGESGQGSEKAFRIQTLEDCMDVLSSEASKRRILTLPKVYQRQWKTILASIPNSEDGSVNPVQMHYLADFFQGHGVNVVCPLTLPQDVSSQPRKSLEDLQEEVDSGALDPLELAARRALAETNPVNEVVDEVEKQFPNLMSPDPLMDSRNVVDFPPTKTNPYHNRVVVRNHYSMFHEALKLDGFDFDSPDWKPHTTDLVEEEVADAELADLDTKAFGRMLMFPLLQRSVIQQTGKGKIRHIQVFVVVGNGKGAVGMGMGTAAEFPEASSKARIAAMKNLDYVDRFEDRTVWTEMETKFGSTRIHLRPRPVGFGLRCGPVMHQILKAAGIKDISGKVWGSRNPIMIMHATLKMLQGGHNPLGMGDGIGGRGKRLFKGTGMKTAYDVERERGRKLMDFRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQV2</accession>
    <name>A0A8H5GQV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQV2"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000055">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="3">
        <location>
            <begin position="88"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="461" mass="51487" checksum="6FCCE5567417E8B9" modified="2022-01-19" version="1">MLVRSVLSRSLRGSRAFATAPQLPSSPQNGRLPNTQSHIVSKLQFFNSVTGGDQQIPTYRVLDGAGRPLDTAEMPDIDEAFARRLYENMQLLPALDNVLYNVQRQGKISFYMTAYGEEATIIGSAAGLANDDEVLVRHSTIAINAKYLGQYREMGVLLWRGFSLDSVMGQCFGNKEDTSGKGRQMPVHFGSSQHHFHTISSPLATQIPQAAGVGFALRRTPERSGKNVAVCYFGEGAASEGDFHAGLLMASTIPSPTLYIARNNGFAISTPSSEQYYGDGIAARGPGYGIDTVRVDGNDVLAVLSAVKDARRRCLEQGRAVLVEAMSYRSSSIRVGHHSTSDDSFAYRARSEVEDWKRIDNPMVRFRLFMESKGWWDSTAEEELKDRQRKEVMKAFKRGESLSRCELKDMFTDVYSGEEPWNLKEQREELSALLRKYGNSWEPWKKELAKFTNQGKELMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSU4</accession>
    <name>A0A8H5GSU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSU4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="673" mass="76842" checksum="4EE844D90DFD450B" modified="2022-01-19" version="1">MATRTQLQTETLEQQEDDSSPTYHMRTPQGNWDSSSQRQRSILNPLFQRSNFPHGPGRTLRSVQRFSSGLGNVIEENPRHNIQNPGPIQEGIRTRNTDPGTRQSPRALGELPTRQQRSDGFIQSILTPGGTVRRPSDPQRRVSFSEDNRSERVGGNIGGNGHGRTAPMQSETPARLPYWEQPIDDGSGDPRPFRERWESLVGTPYLPPNVPVGPRQSYRYLDIPPPSARTNETFDSQRTATEYDFDAMSSEEALETFVVLSRRLLNRLCSVTGENPGYDEMNQADYVRTIRRINSAAHGQLPREIEEFFRNLRNEWDLRHLSVLAGHPRILRIVPYEPKLDNIDQEMLDMYVYDDTSTHVPIPERDIGQSEGEEAPEDNQTLVPGEDKPLTVEEQEAVVLALHYFRQLTGEKLDEEKALEEFKILFSGTELDGLLKSPQREEPLGDLMPRSDEEINLEEAVNPGEAEQTALTHEIPSQSAHQPRFDILGHEIPSRSAYQSPFDILSGIRTFTTPPIRSLLVPGQMRPQGYPYTPIPKRIRESRQAESNSRVEEREGSIAGSIKTPGVIADEKQSRKQQVTLEEVEDEDNIRRKRWEARRQQVIIEEVEDEDNIRQKRWETSGPSSETRRTSPPRYTTTEKGKQPIREGEKNIRRYPTSCERPTLARKNAKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT27</accession>
    <name>A0A8H5GT27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT27"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="840" mass="94229" checksum="2D58042A1B04FC75" modified="2022-01-19" version="1">MPPKAAGKAAKPAKTSASRVLITTGPKDVSKAHGKGDGTRDERPTTTRALILRKSKYGAFGEGEVFLMSKMTGREKLDLLAEDLIEKSSKAVMAPFRIERCITIAESQCSRYLDEITNMKDKDFFYSIITEEVKARNLAEQAKNKGNDRSRDPSFIASAISHKVHNAYLLASGWKFVTETLYTLAEEGLTDERVTQQLGENEELRSRYLALYHLVSDLVDLGQNKFSVLATTTPHYAKYFKTVEDELGEKQVKFDDQALRGACTSFLDSVIVELCFPRGKYPKAILYQILHDAVEEAPKEARRFPQLLWDFVGDLSDSVLIQQLLEAPLHGEIQKWRDEPRKQTEEYDRWTDAVVASLVAADMFANFKDTVVPLEKTKQADTLTKMWKFINQNYKAVAGKDIDTLWNLSKDLEPTPQWHYFVINHRASHFDEDKAQPAGAKKKLLAIKNEPDSDTDDSMPALQDVSDSDESEIWSDDEDEDDSDSDGDESYDSGYNTDQEDEIRDLVREAMDAAHDPHFMDDEDTDSTEDVRKGNPFLKLLGRVFSPNSKLQTPAAGARAPPQPASSKKQKTATTSPQTRSRMTTVEEVEDEDDAVRASKKKKKKPKKKKKTTTEPSAEDAASVATPPPRTPSPPPPSPPPVAKPSPKRAAAKPKPAVKPTPAAGQSFTSLSLPVLEQTETAQSARSYLQSQPEGKEKIKSRGKEASIFSSVKRKLGVSREDRDEKEVKEEKKQKKKWFASLGKKTRAYMHQLLNTPENETKGAAGMKWDTFVKVMEDVGFKYDPSTAGSSVKFVPPDPRDPPITFHKPHPDPTLQPVMLKEFSKKLRRYYGWSPEDLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU15</accession>
    <name>A0A8H5GU15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU15"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="322" mass="34517" checksum="7CE006B86316FE1F" modified="2022-01-19" version="1">MSEQKALFLESKQGRFVVSTRPKPTSVPAGELLVKIKASALNPVDWKIQAFGLFIEKYPAVLGNDIAGEVETVGEGVTGFSKGDRVLFQGFFVNNEYQDSSTSVPLGLTTASVGLFSNEPAGLGLNPSFDANVKHSGPVLVIGASTSVGQFSIQLLRLVKFSPIIAYASAHQFDYLKSLGATEFIDRKQVSFSDLPAAVKKITSEPIKVVYDAFSSADSQQAGYDILADGGTIIVTTGDQVKNKVNGKKVLAVLGNVHPPVNREFGKVQYRNLTKYLQDGTIVPNRTEELPNGLAGIPDGLERLKNDQVSGTKLISLPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUH5</accession>
    <name>A0A8H5GUH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUH5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="80" mass="9039" checksum="3A4A1DF1F18AB301" modified="2022-01-19" version="1">MSKVYAITMFALLNSRENLRKIVAGTGVESIHFNYEMNSMMQSQPHESHQPMSNTTARNEDGNGQPKNQDLVIGPEIHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUN2</accession>
    <name>A0A8H5GUN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUN2"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="40694" checksum="832A48919AB88404" modified="2022-01-19" version="1">MDANLNNNRAHVSMNYCFRTAKAAGLIDVHTRKLKDFTEDDTIPPYVILSHRWVHDEEVNYRDFLELLSKTKKKSGYRKIKGACKQASLDGHHFIWIDTCCLDQDDSDDVARNINSMYSYYRNSTVCYTYLSDVYTPKYGFSKAGAWSDSGWFGRGWTLQELLAPRKVVFFNARWEFVGDKDQLKFPISRLTGIPSSVLDGSSSMEDIDLQERMAWCAGRRTTKPPDLAYCLLGILGVSMTPDYTEDARTALQRLQKVLVQSYPDRFLEFRGDDIYAMLLRKNARSWIGTGSDSSPSPENNAVVSYSSPNDYDSISLLHPDSKHFVTTTCSVEVGPFVQEPVILVDLRHKLALAGLGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW09</accession>
    <name>A0A8H5GW09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW09"/>
    <dbReference type="OrthoDB" id="3249498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06222">
        <property type="entry name" value="RNase_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044730">
        <property type="entry name" value="RNase_H-like_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="21325" checksum="AF0EB1D68ECD7EC6" modified="2022-01-19" version="1">MAGKTEPFQLIWVSVALCRELLWMAERLEASDGVLLLGSLEWSRSEADLVLYTDASATGMGIWCPSLLHASHCPIDTPDPTRICFYKALAVVSALSFAASFNCFHHVIIFTDNSNTVSMFNSLHAKPDYNPLLITAMNILLDTNMQLRVLHIPGSSNVVADAISRSKFEVVRSEAPKATLHSFTPPELSSGSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW55</accession>
    <name>A0A8H5GW55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW55"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034227950" evidence="3">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="476" mass="51405" checksum="B6FB0E2F7EEEFB3C" modified="2022-01-19" version="1">MVLGLMYASIVTVLCLVPIVTSLQVQINSLPETITPGATGFVTWQADSVEDAIHWTLEFLQNDSPIGVLSLTWDLFKTIGTRPLTIPAVATPGIVQMIATGSGLGGEISSTVTAIPGSLLVQLPERTITPAIESTDNPSNGAGSTGTANIGTSTSEPQRPTRNDPQTSTSGFAPTAVPSRSNTDTTSGSLLQTTNPSMTSSSTTPLGSTNPSFTSSLSTSDTTVTSTQPSDASGAKTNRLAIILPSVIGASLFSIILILIFWRYRRRQRLKVQSSGNYDSESLPSRMLGPGDFKSISMNSPDIPEPFPGERGVMRGSDVRGGTSHFSEIMEPFSRLPWNRNGNTLAQPHPYELKPDYSEPIPSRQSVVSSVEAIFQPLSPLTLISNTRPRSHSEFSIIIRSPTQTESNVTSRQHRLQEEADQMRARLSALGRDPARSEVTQEDMGRIREQIERLEILVMSNWARGLTDEPPPMYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWA7</accession>
    <name>A0A8H5GWA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWA7"/>
    <dbReference type="OrthoDB" id="3070875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="59340" checksum="93F9CB26B2F2B888" modified="2022-01-19" version="1">MVPCCGKYNCLYSQCISVTPRQHLLATPSPFPLSSHFISSFLELHSSRTLAMTHLQFVTLLSILPLVTRSLEIHVNQPFPSITPGAQISVTWQRDTSGPHQDPSNWNLEFLLNNAEPGPLISVSNADAQSGSMTVTIPPFATPGQPIQLVAIDDKHGSTFATFPKDPVTVQSALSSKVTETGSETSASVPSTSISPTHEGEAGAGARAGAGAGNFSSTPSDTGTSSDSTTSNETTSIFMSLPTSMGSGENGSVPVTDSSLSVLPTRTSDISTTPAATGDSGVDASPPIAPPIATTTSPNDTASSFNGHHTNRAAIIAGSVGGGLALILLLTFIYCFWRRRQTKRQFVTESDHTSFDRDMMIRSNSDTVILSTGDHHDLKPKTSDMFKFEPLSASTIGVALGQSRGLGSEKANEKAQVKLESHRSSSSVSSARSSTSVDDEETTPSLVRYSSGKDEIRSQAITSIYSTPYTPISKNHTRIPARTDRQMDIQGQIMDLQQRMIGKSGTTSAKELNEIRENIKHLEELHKTDWALELTDVPPPGLGTGLDQRRNSVGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWB7</accession>
    <name>A0A8H5GWB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWB7"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="528" mass="57545" checksum="0EA47EFFDF58DD05" modified="2022-01-19" version="1">MGFEIYACAKMAGKYPSPSAVCNFFVLNMVVTQAVLSDDSVLSQYNTSSSSSSSSAVPTAKEKIRRPPNAWILFRSAKCTEFTTIYQAENNGKKPSQADLSRMISNAWNTASPDVRVHYERLAEEAKVEHKKTYPDYVYNPQHKKNKNEMPPEEKKKRKKAKRVKAEYQAAVSGPQRSSTVTARRYSPYSSSSSSSTCPPPRDTHPTVYGGQLGSSGYIENLTFFHYNPINTSNSVRSPQQPAPATGDTPIMMPPTPTQPIGTTSTLDSMANTYATNANANIDNLDATGAIPIFNVYDAFAYESDASSLSPTTALPPSNQYLLYPTNPYIPSASLPLDVDSSELFSLNVDINNHADFEGAGADVSVLSTPQAEVNDSQSQSQTSSSAPPPSQDNVDATAHPDPSSSSSSHSLSSFSPSSSFTRQYEALHRAALVRIFKFRISWSDHNTNLNLNTDTNDGPGKINPYSSVVSDLDHFAVEVNDPMAIRLGDLDFNFDFADSRHGDGFDGFDGWDSDGSLWGNALPPTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX55</accession>
    <name>A0A8H5GX55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX55"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="41088" checksum="18E61CC2EBC4DA6E" modified="2022-01-19" version="1">MGYPVTPSFDEILKNKLYIGNLATAKSSGTLAAIGITHIVSVCQELSSTGPKHLAVAVADCEYDDLLIHLPSTCQFIQQALDEGGRVLVHCVMGISRSATVAAAYSLGRPCIQPNYGFIKQLDAFEDCAYSPSTRNAVYVSWKRKQGQKVTAFLNQMIDTVAIIPNQLFLSSEFPDDAQQAESLMIELGIFHLVSVSPFTVPHLRSTVQQFSIDDLSQDALLVTIPQACNFIREAIANNHRVLVYSDVECKAAIVVCCYLMCTQNLNPNEAHEILGKALPLFHRTANFSRHLELFGACGFAPSSDHPLVKEWVGESSPLSCTPKESYSKEMAAAITATAMASVLSDTSIDIGAFGETLKKIQHSCSRNDRVPATAVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX98</accession>
    <name>A0A8H5GX98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX98"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="112" mass="12442" checksum="47DBEDA3B6CC6BE1" modified="2022-01-19" version="1">MPGKHQQFLEHLDRIPHSICKLAPTTPALREPYNSAVMAMKKLRDLHMRIVYLYIINMSKTSCPGYSCPAQAMLKSLEEDQQSVRESIRGTGGTSLVALLKAGRDATTQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXS8</accession>
    <name>A0A8H5GXS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXS8"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5372972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="518" mass="55670" checksum="292AE9E5F4143288" modified="2022-01-19" version="1">MPSRTDHHDEESPLLPRRRPTPLPITHLLTVCLVRLAEPIAFCQIFPYINEFIAYLHVTDDPSQTGFYSGIVESTFALTQLLSIYTCSRLSDSIGRKPVIIAGTIGVGLATIFFGLSTSLTSLLLSRSLAGLCAGTAAVMHAVLGEITDKTNQAKAFPMYGLVWPLGGIIGPLIGGSLSEPAKRFPELFKDTIFDYHPFFLPCFIAGCVSLCGVILAWLCLEETLPSKAKPKAKLEAQEQEQANVKTYADEDQGSDRSSSPSPSPSPSRSASSSSTITLTSPDQNPKAKPTPSLLTLLQIPIIRSLCLSGFTLEMNAIAFNVLFVLFSYTAVSDGSGGGGLGLPPTSIGYALATSGFISITIQIFLLPFLLKRWKAESIYHFSMKLWVLVWIGLGSLGWVAKLGTTYDETRVDETESRVVLWIGIGIVLALARFAGLGFGVSMILIRNNTHDSEVLGTTNGLVQLFMCTARMVTPTIVSSAFALCQEPPLSNLFTLGPVSLGSYLWVALCVGCALGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIY7</accession>
    <name>A0A8H5LIY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIY7"/>
    <dbReference type="OrthoDB" id="3266192at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5359061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="279" mass="31501" checksum="F1BCB2215B50B698" modified="2022-01-19" version="1">MEITLKMKCNPEHIPLILKVIQANGTSWFNDNIWKSEIMYTFWLEFTKSLWDHQLGTPSMQTSKVLIVRCWEVLVGFSYGQPARKPSVDRIIDIVELCVRTRRPKPCSPLSVAILKERAPTKVNFTSFYEVLISLTVQTKDLDVCTPPFNQVMEVLIGAYLQNVVGPKSATIASLRTRNIECGCANCADVNRFLQSPSTELRVNKQPRFNLLHVCGYLNTATDLVTYTVGNYSRPTPVTVRKTPILLAYVQWAQRQTKAQAFLTTVGTDDVIAKVVGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLE5</accession>
    <name>A0A8H5LLE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLE5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="103" mass="11096" checksum="5286F37E1F214447" modified="2022-01-19" version="1">MTNRYTRLLELSPESHEPTAQCGLQAQSALKAAWSVAAHYLSSNATAETTSAIALAVFEAFSGHIVCKDCLDQRSKAVVNVVEKWDEIVLLPFNVSNATSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPW5</accession>
    <name>A0A8H5LPW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_003326</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPW5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="65"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1046"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="488"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1074"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5365630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1121" mass="124827" checksum="520AE54D4DC1B4D5" modified="2022-01-19" version="1">MATRRPPSSRTRVPSSSSMAPPQQRSRSAMSKLASSTRSAEDQQDTIPHTSHLRPVKPNEEAETNIKVVIRCRRRSDREIQDNSPIIVSSEGAKSNQVSIETTAPVSTFGLVSLPPVRTYPFDLVFGPEADQAMVYHEVVGPMLEDVLKGYNCTLFAYGQTGTGKTYTMQGDLAPTPMGNPSVHAGMIPRVLFRLFHNLEQSGADFDVRASFMELYNEELRDLLASELSAPIGSMQPMGMASRDAKGSEGGLKIFDDPNKQGVVVQGLEEIHVRNSTEALNVLTKGSHRRQIAATKFNDHSSRSHSIFSLTIRVREVGSKGEELLKVGKLNLVDLAGSENVGRSGAENKRAREAGMINQSLLTLGRVINALVDKANHVPYRESKLTRLLQDSLGGCTKTCIIATVSPARSNLEETLSTLDYAMRAKSIRNKPELNQRMTRNALLKEYVAEIERLKADVLATREKNGIFFSEETWAQMTAEQELRQTEIAEAKKHVEIVENQMRVVREEFEQSIGLLMKRDAELKGTKEKLQETEQELNDREGELRQTKVALEEEVIVREAHQDTEATLDAVAGGLKTVAHDSIRDISGLFAKIQRKTSVLNSNSNAVTIQGNTLIAIYQAMFQTLDDFVGSSSQHSAKLHENVQLFHKDQSQSFSASSKRILQQLESIEQSLQHIRSRDSTETETMATVKKLLRETQETFNTGFVEWGQSLQKSYNGMHREVGKVASLSLGEAETALKAIYALLDGALQETSTFIDTERRALVEANSLTQETASREIARLKAQNEQLMQLVATQRLESAKAKDDLLQRMSSMLTDFVSKQDQGLQEGLASLQHGNSLAEQDMKTYAERHSGLVDVLDKQSDVFAGSLRRTGGESKRTRDGALKTLKTAESTIRTRLDETQQDISTSFEKYSKDLRAYTQATSKSSNDAFEHHSRAKRARLDLHDRMNADIQSEFRSLHDGLSTMAADSDRFCQESASHGTSLADVTLKYNDTTGNHLSSLKTAITSLVHEGTQEDAPTGSTPRKRNWQYIDHWDLTKSREELLNARRQDHVSSTEDEEMPAEENDDFGEEEPLHLSSSSSETLASSLPRQRSASVLKQPKAPQIPLVDTRNTYTTRASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUQ1</accession>
    <name>A0A8H5LUQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUQ1"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="159"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="355"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63243" checksum="F32F447F26F5EB49" modified="2022-01-19" version="1">MKRKAGAALRQPPAKRATRSSAAQNDPDPSHSDDQLDCIPTTRRSTKRVQFHPPALPSPPRPEPSPVKPQATIKRPSRASPKKPAQLETPSLTPPPRPASPTKKALAHLPPHLHESLDRQKSAILQNLHSPALIHDYDEEDEEQDAPANLLAAQHVGDLLKGTTERGEGNSCLLLGPRASGKTKVIEQCISELSQEPIVVHLSGWIHHNDRLAMREIAYQLNQQTSASFLPEGLEVDGDAENPFMDDTVSGLDSIPTAHLHALISCIPTLPRPTIVILDGFDLFTLHPRQSLLYSLLDTVQSLRMGPGIKGLAVVGLTSRMDTINLLEKRVKSRFSGRMIRTAPPRKPAEWTHTARAMLMPKIEVDSMDVKDEFTELWKTRVDDFLADPKIARIFEETFSVTRDLRTLSRLLIQPVLSLTPNSPWLTSEQLERSAVAQRIRPEYPELHKLTYPSLCLLVASVHAETAGYPAVTFEMLHEYICTRIRTSSSAPVQINGRSIGMVKIPRLVLLSTFEKLVSAKMFVATAAHSLTIGKEFVRYRCAIHRQDIKQAIDKSGQTNLKTWLNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV65</accession>
    <name>A0A8H5LV65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-dependent phosphotriesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV65"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="41945" checksum="97C85651AA486856" modified="2022-01-19" version="1">MASTLITILVLLVAIAAGLYQFYGVPLLTVIGYWRVVQPIGNTDCTTVPELKACEKIVVHDPTGVLYLACSTPENRLKWIPAAGILNENPHEDYIATYDPSTSKVTRLQIENFNSGRGLSVHGMDVVPSDTNPSELYVYAVNHRLPLDGKDPKVVGADSVIEIFKTRVGSSSLAHVNTVEDSTVLTTPNDVTGFSDGKSFFFTNDHGPHKTGTLKGLRNMFTSIASVGYCHVEHGCSIVVPKMHAANGITKAPNGTIYVGSFFGAGISVFERQEDNSLVLTDFISSNDIPLDNLSIDTEGAVWGAGIVKANILSQYMKDPSVLSPTRAVKFTVNTGPGSFYGEKYRVETAFEDDGKIATGTTSVAHDALRKRLFIHGIMAPWLTICKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVI8</accession>
    <name>A0A8H5LVI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVI8"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="339" mass="37581" checksum="4E88946AB4DABDC2" modified="2022-01-19" version="1">MDADGKYGDGHVILMLSRVCCFYSSDSQPASVNVFSVLIAQLLPPAPSVPTLLTMAPGLRLKSIQVTQADATTLVEDKETYVYSVAVTDGKRTYNTPWANECRWEVDYPIEPSDTVHAVSLELYRKRKKLQRLPCSRKLGKASFDTQMIEDTEEVGEAKGPETSSSANSDPSGTLGAPPNVALPDIPKKLLDNAETLGGVLQLIQPFKEVFDNIAEVHPVAKGAWLVVSGAYQVLKNQHDRDGQLVDLYNLMMKTYEIATENDLYQQDGDKKLCAVIDAMVKHSKECSIFISNYGSRGYLYRILTGSEASTRIQDYRVSFSDLQKAFTSDQIDLTTREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY58</accession>
    <name>A0A8H5LY58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NPR2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY58"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="72675" checksum="4076C8DDFBA5FD7A" modified="2022-01-19" version="1">MSFLPRISSVFYVGFDVVTGPKIIAQVPEDLIAVPQSLPSASLPPTPGVETLPVLSSPHKIKSASILFHFEEISKYVIPPPALCGRLVTCTTKKHRIIGLPSQIPGKKYQRNFFRYNLCFVFERSADLSCYEPIVRKVSRVLSSCEAESEFLSSASPAKMHAIIEQLYEDLNSYSETSIPIDHFNTIELKIFPFYPNPQAVKDWMVPVALINLTRRIEDNWDLTMAKVCRFIDGVNHVSRIAHLAECDIELTRQAISHLLYYQVIMTIDIFQYSNMYTLQKSIQWLADEAHVKEECGLYCTKPGNAAPDWPELLHLYSRLRPGKTVLEWMEEHNVNGVGIDVRRFTSFGVIKGFLRRVHRWPVLVESTKPAASSLEAPPGPDASLAGDDLFVRKRGRSFAGAPIETSAMDSHSQTQQFFRGRTPQSMAAPALNSDQATSAPTTPREAAVSGVEPREMSFSPPLAQVQAHHRTRRSSAAERILEQLRNRDQNVNRGPLASPRTSWLQYPSEHSPLLTGIPGITTTSSTPQDDSSPSYPQNPRLGGITSRRSSLTTTYANVNGPPNAALTAPRPRMSRSPSAPVVRTLNGVLGKSDSGPGLSVMYPPELVKLLDGEHHTDELAVRFEAGWPLLEEWLTQIGGGKEPGDFGRISIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ52</accession>
    <name>A0A8H5LZ52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ52"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5374887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="582" mass="65368" checksum="BFBEA41B6C476FD3" modified="2022-01-19" version="1">MTSLVSGYSSGEDEDVAAGNVFGLSQPSAKKLRVEESTPLVADAAPHVLSEDPLHQTSLVTRPTDTQMNVNISYDDMMLPVQGPENPFGDKKRFLNQNALAGHVEEQDMTEHAFRSQHLTHSILGYSANPSVDPNAPVVMGSLEAAQANGFATLDTIRVPRSQRKELKRKRKEMGDVEVVEGEGAYIGPWASWKGDEPENHFLTGLQDDVEVEEEEEEEEEEEPKLPKKARKPKPGAYGEESSIFHGKSMTDYQGRTYMSPPVAEAPSLLAEPGSQDCFIPKVCIHTWTGHTQGVSVIRLFPDTGHLMLSGSMDTKIKLWDVYTHGNCLRTFHGHVKAVKDLTFSNDGRQFLSCSYDRTIKLWDTETGQCLKRFGNGKIPYVVRFHPDQDKQNIFLAGMSDKKIIQYDMNTGEITQEYDQHLGPVNTITFVDENRRFVTTSDDKTIRAWDFDIPVVIKYIAEPHMHSMPAVTLHPSKRYFAAQSLDNQILVYSTDNFRQNRKKRFAGHPVAGYACQVGFSPDGKWISSGDGEGNVVFWDWKTGRIKSRLKCHSKVVIAHEWLPHETSKVVTASWDGLIKLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ARL5</accession>
    <name>A0A8H5ARL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000631">
        <property type="protein sequence ID" value="KAF5309636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ARL5"/>
    <dbReference type="OrthoDB" id="3257409at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10775">
        <property type="entry name" value="OS08G0208400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10775:SF185">
        <property type="entry name" value="OS08G0208400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5309636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="504" mass="58252" checksum="2F1DD00139359B8E" modified="2022-01-19" version="1">MSESGKKRRKIIVCILFVFPHLDHHYNTVFFFFYFGPMTTSSELVFCVLCDKLTSEWHERRHRKSVPAPVPPIAAANTSSHFIVVASDSESSSDDDSETSARSLARNTHDYDVPDNPHVHFDEIPFHFVDEVDNNLHQASRPFIGPIFDPYQWLHDNYPTAEIWDSEEEDRETWLKRTAPPPGVSIEAHERQLQEERRLRDQDRTAGLDNEEEEVTNLSQRIKSWHALWESSSESDGADGSDAESESDVEEEDVGIDWDAFERAAAGVSAFDRLGEKFQAEVFDGVDRLSELDKAICHAYAWKVQSHTADEYYQHAPQAFGPRQGEPLPKLHTQRRRLLFLAGFKPQEYHCCINSCVCYAGTYADHQQCPYCKEPRFKPSGKPRKFFTYIPLIPRLRALFQNHDLAKKMRYRHDRLAKDVIEDIFDGEQYKELRNTSVHVGDTHYDRNYFSDPREVALGLSTDGFCPFKKRNKTAWPIILIPCRTLPSRTHSFPWCHPGTQETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B625</accession>
    <name>A0A8H5B625_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000479">
        <property type="protein sequence ID" value="KAF5317464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B625"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034525093" description="Non-haem dioxygenase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5317464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="23884" checksum="4162DC1AF2632BAC" modified="2022-01-19" version="1">MASFGFLSTLLDLLFKGLKPGPTRADITPYAFPPTTKDNLEYADLAIIDLSKMSTPEGRKELTAQLSRAMHETGFFYVINHGYTQEQTNRIFSIANLIFDDVSDEEKALYTGKSPTVYEGYKPKQTWKIQEGVRDQIEHYNLNRKVDRRTHPEPVRPYLKEIQDFAYHNHHNVLYPVLRLLAAGLELPEDTLVKQHQWDAASESSGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6E3</accession>
    <name>A0A8H5B6E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_019087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000477">
        <property type="protein sequence ID" value="KAF5317481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6E3"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5317481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56377" checksum="80ABC8FDFAA24995" modified="2022-01-19" version="1">MTERRSASADPKLHCANRPHVFHPASNQDACYIPENSDDPWVPCTTQPCLNRYNTQRLTDVELPSWLHVITQLQELAIQKAHRKPRTKSGQGTPTPTNQPSEPDPVPETPSNNPSEPNNPTPPPSSPIIPSAEGPSVAPHRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDAFNGERSKAKRWLALFNNYLRMNKGKYPTEESQVSLFLSFFTGEKGGDWATQRLIERDADEEDENLASTPGEWRWITLKQIRDRFKKDFKALASEDVARTKIKFARMKGTDISSYNSIFDTYGEESEFRDAALLEFYQDGLPPKLREAVGRTYPKWDDFEEYKERAVELHLEWLKERERQGRWKTTSTLKSNPGPSQGRTVASVNALMGPGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTPSQNTSRTFPSRAIRTAETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BS97</accession>
    <name>A0A8H5BS97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000367">
        <property type="protein sequence ID" value="KAF5328141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BS97"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5328141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35870" checksum="38C15FC05E2B05A4" modified="2022-01-19" version="1">MSISGLLRCINRSVATLEEPSSIFLIDSHVSRRTTAPDSLPLPVEAPSSSKVSKLFNSGGDVIFRSSDNVLFYIQQKYLEANAEGFPLAEHTTKGVDEVVPLTESSNILELLFQFTYPQMPPDLAELEFPELMELAEAAEKYLIHHGRQFCLMRIGAFVTQYPLEIFAFAAEHDHMKLVYEVAPRLVGKPLSEIAYRIPSGLYIPWSLYHDQFISNLGKQAIDHTFSQPDTLNCSNNTNHTNHWRRLVAEWRAKMSNDMSLLVDLDESLHISPEYLGSCCNAFVNWRDRVKKPKRTSSLEHFVKQHRAKRSGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVN7</accession>
    <name>A0A8H5BVN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000334">
        <property type="protein sequence ID" value="KAF5330099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVN7"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5330099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="505" mass="56413" checksum="8C15689349CD27D6" modified="2022-01-19" version="1">MTDRRAASADPNLQCANRPHVFHPSSTRDAAYFVEDIDDPWTLCTVQPCLNRYNTQKLPVEKILNGLHVITQLQELAIQKAHPKPKPATESEQGTSTPTNQPSGSNPVPETPSDNPPEPDNPTPPASSPTIPSTKGPSVAPRRPPTPPSPDPSDLNNSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLALFNNYLRMNKGKYPTEESQVSLFLSFFTGEKGGDWATQRLIERDADEENENLANTPGEWRWITLKQIRDRFKKDFKALALEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFRDAALLEFYQDGLPPKLREAVGRTYPKWDDFEEYKERAVELHLEWLKEQERQGRWKATSTSKSSPGPSQGRTVASVNALMGPGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTLSQNTSRTFPSRTIRTAETTSPPPMTVAQASSSRNTIKDISDMVNRVKGLEGEEKEQATVYLKDVMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BY24</accession>
    <name>A0A8H5BY24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000327">
        <property type="protein sequence ID" value="KAF5331314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BY24"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="113"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="246"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="457"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5331314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66603" checksum="E1151F9099E57F20" modified="2022-01-19" version="1">MSGAVPHVRAPLSILVMVQNCRSRFSFKPSTWPMGCSMLSLRKASPQSNGTNVKCLSIKTRLRHEFFSALQCSKFFNMYQLSLASAALLALLQPVSGAVFPPRPGVLPITLNIENKNLAPDGFTRSMIVANGTYPGPPILATKGQTLRVTANNKLTDGSMRLSTSLDFDGIFFTGENLYNEGSPFVTTCPIGPGASYTYEVPLGTQTGTYWYHSQLSVQYLDGLRGPLIIYDPNDPLGHLYDVDDESTIIQVGDWWHNSSVPLLQQFNDTGIIPVSDSGTINGVGRFNGGPEVPFPVINVEHGKRYRFRIINQSVRSVFTVDFDKHPMTVIAADGVPTQPHVVNTIEMLAGQRYDVVVTANQPVGNYWFNAPYVGGSAARNPNQNATLNRAVLRYRGAPKVEPQGPFTAPILDQGFLLESDLRPLFPQPAPTPTHNLSFELVVTDGLAVWHINGVQYIPPKDPTLLQVLEGATTNSSFNEHENTFVFPLGSVIQVDFPPSDDDDAHPFHLHGMNFFVVKSNTSDVINTRDPIRRDTVASGQAGTTIRFVLDQPGPFFFHCHIFWHMQAGLGSVMLPDPQGSRKIVRPGPEWDALCPAYNALSPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZX3</accession>
    <name>A0A8H5BZX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZX3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5331447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="39932" checksum="CE835505A67DB1BC" modified="2022-01-19" version="1">MDTLHTQEEASFPIPEAMYSSRFSDQVFDSLASSLFDCSQSQTQNGQRTTLISVDGMEALTGGQQGNVDAARSLSSVATGHVFHISTLKFGSFNAPLSYLHISSVSVLPTGLHLVTRSPFRSLMTFDNSCEGEIYGRLKDFRTSGSNFLAFGRTLPTQIKGQRTTPPPVPVYPNGLRQTGRLDPETYPPSIHAQAGFWALEYYLAVQSNGHRGSLVTKREYSCVQYQAPVKMTLADPNEPSRPRTSRSRINVSLSPSHLQTPFYTLRSVCGIPEHTQQTDNDLRNSSMHLSSCYSPKLTAPVNKSTHDVYQSPALPRALLCPIELLEYISGIDFSLLVSRLNIQHLSVFTLSRVFPGIHGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C271</accession>
    <name>A0A8H5C271_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_017180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000286">
        <property type="protein sequence ID" value="KAF5333785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="611"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="854"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5333785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1461" mass="165024" checksum="7E4E56D1350F6B56" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQVQPLDPLFQNPLPFPLDPIMSDAGEHTRTDVRDTAPTSPSSPPSTSTSSVALSVPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYTEESDAIELIEKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAAPFQKPSDVKKDRKCFNCNKMGHTTLTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWVQSISSSDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLRLAGDMRVEVRKDNADYTFTFHDHLCIIRNDKDNFIGVIHESAKLYSITTKKLSDNVATLSLYELHKQIGHMSYTNLKTLLKTDKSIITTIINDWTETQCEDCIINNIHRLSVPKQRTSELAENFGDHFHIDIFGPLRTASIEGYKYWLTIVDDCTRWLILSPLKTKDEAYTQWVTFTTELFTQYGIKVKILQSDNDAVFTSGAFKNYLKAQGTIARYTVHDTPQQNGVAENIHQHIMNGIRVNLHTGKLPNRLWWHAGLYTMYILNRSPKTALKMQTPYFKRYGVNANLDNLHSFGTPCIVYDEARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTTETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYADNIGDPISFKDVLNHPQRDAWFDSMKAEIESLESLGTWEYVKPPADANIIGSRFVYKTKYELGKQTKLKSRLVAQGFSQQEGIDYYANDIFAPVARMSSTRFILALAASLDYETTQIDIKSAYLYGNVTDEETLYLRPPPGNLLPNLPEGYVLKLRKTLYGLKQAGRRWYEKLCNILIKLLGLKKSTYDNAVFYRYHENKLILILSCHVDDITLCTINKATAQAFVTALSGHVQVTDGGEIHWILGMEIQRDRNNHTIKLRQKHYIENILKRYNFDQLHARRTPMLPGQNLSPRPGSELQRDAAAIKHYMSLVGGLRYVADCTRPDITYCTGQLARYLNDPGEEHYAAAKQCYLYLKGTCDYWLNLGSPTITSTYGFADSDGMSTYGNKPIMGYAFKFAESLISWSSKRGTLVTLSVTEAELCALAHASQEAIYLKGFIEEILNAEQEPVLINSDSASTLAIIRAPEEQHTQRTKHFNIRKNFLTDRIHQRYIRVKHVSTNDQLADILTKALSADKIKRFSRLLGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2Z8</accession>
    <name>A0A8H5C2Z8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000271">
        <property type="protein sequence ID" value="KAF5334071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2Z8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="7218" checksum="C1A781199DD81587" modified="2022-01-19" version="1">MSLFHEFLSGFKLKYRLAFDRASSSTSSTTSSYSFSSPAVARAHTDPEEGEKPVYEERMCMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3U5</accession>
    <name>A0A8H5C3U5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3U5"/>
    <dbReference type="OrthoDB" id="2637653at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="419" mass="47030" checksum="588DB29424E912D8" modified="2022-01-19" version="1">MLYALTSSPSASSLPESDFTLSAQAVSRSFVASLAFLLYDILLTLDEEIELIWNRRKWSLFKFLYFYVRYVPFMLQLSVVFIQIHPLSTLTFSPLLLVGTEITPQLHFTSNDCSIWQIYQGCLTIVVFAPVDYILVARIYALFHSAPLVQLFISVCYVASVIAMSVGLALAVPEVTFDGICHTTNVSRKVLINGGAEVTFQTILFILTLYKFISMLREEGWVVVKAVPLLRIIIKDGIWAFFVLFTLVAAQALVYVAGREGGILYGWVLCAFSFSGYRILLNLNHIPRSRSRPQRNHCQRRSYSSPGQSNSYTPIPRTGLLRQIPQWAEYISPVSFDDWNDHYHDHDHAYAGGDENAESTHPFFTSIYNTNGIFSEGAMTGTEMEFATTPTTSGMYMGTGTGTEEIELVEVVPVSSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4S4</accession>
    <name>A0A8H5C4S4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000269">
        <property type="protein sequence ID" value="KAF5334118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4S4"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5334118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="826" mass="92810" checksum="FB9672DFA0A8F1AF" modified="2022-01-19" version="1">MSDNEDKSRSGSQKRRRLQNACDECRKRKIKCDSAKMPGNRCTHCISLEIDCTHVLASIKKKRGPPFGKPRGSKSIRSTVSAILSTTKPFEVPDTPEAVLKLFKDLATYVRKLEEELDELQQRIPALPGWSQQNVLSDETAEQDARSLEGLSEQLKRLVLSQSFKRHFGTSSSLTLVRHAMDDVHLPQDIHLPSSHAARYLKARRPEFWAVYQWQIPPQEDLKPLAFPETDLMKKLIDLYFVNHGQYLPILHRPTFDRSVAEGMHLRNRNFGCVLLGVCALGSRYCDDPAVLAPEAPEFSAGWKYFRQIRPIPITYSAAPSLYQLQTICISIFFLEATSTPESVWVQVAVGIRLAQEVGAHRRRQGQKPTIEGELWKRVFWMLYSCDIYVSASLGRPRATSSDDFDIDLPVQCDDEYWEHPDPELAFKQPPGRPSKLVYLVTFLRLLDILNIAQKTIYLTRRSDTWSMMGRSDLEWSRRTVSELDSMLNNWIDTIPEHLKWNPNREDTVFFHQSVSLYKLPSLRWLFAPMQQDQLCHVMEVQQCRGSLPLVNVVLTLHNAAIVLLLNAWRGKHLRTTPGTNNELVDVYKCIGMLRSYEGRWQRAGTYCDIIREILAISNLYSPEPSDAGCLKRYRDSKDDSSTGGQQPTSSPNSNSSSSSSSLPSSSGSGEPRKIAGTHRVSALASRQSSGNGTSHGTTTTLNIDPIFNLPLRSNELGSLPLHESFDPFGDAQAFVNSSIWMAELFQTDSEESQVPVTGTGGGDGRIFCAEPSIQSLNLPSQQMGQTILVDSGSSAIDSDPTTMSSSDWDAYIANVDDLLRSFMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C559</accession>
    <name>A0A8H5C559_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000252">
        <property type="protein sequence ID" value="KAF5334741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C559"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23998" checksum="BD2791AF45471B0F" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKFTGRKIDANALIDSGAEGIIINGQFTQKHQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQKLRIYSRDGVAYHEEEAEFYVMDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKPLKSTVADPRTHHKDYQGDVVKFLSDPSTEVRKKRRSLLKTTTEEIRSQNDGNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5T4</accession>
    <name>A0A8H5C5T4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_016236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000244">
        <property type="protein sequence ID" value="KAF5335259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5T4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034270427" description="Cytochrome P450" evidence="11">
        <location>
            <begin position="26"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5335259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56481" checksum="30BD03A58EF80F1F" modified="2022-01-19" version="1">MLVVYSSLAALVVLLAILVLRRSNSKLPPGPKGHWLFGNAFQVPLRNPWEWFQTVGIQLNSEIISLDMFGKPMIVVNSQAAADELFGRRSTNFADRPTFPMINDLMGFDWNIAFMKYGERWKARRAIFRKTFQPPAIYDYKPNIERGARTLLKLLFEKPEDFPRWIRHSIGVIILSSTHGIDVRMDHDPYMDAAEKSTDALSHAITPGAFLVDSIPLLKYVPDWFPGAGFKIKAKEWKKAATRAPQITFDYAKGEIERGTNKPSVVSRYLKDLEENGTWSKEQEDAVRDASGVMVFAGTESAASSISTFLLAMVLHPEKQKKAQEAIDVAIGQERLPDFSDEGKIPYIEALSREVLRWRPVAPTGVPHYTNKPDHYQGYYIPANCLVIGNSWAILHDSAVYGADADDFNPDRFMTNGELNKDMPDVKATFGFGRRACAGQYMAELSLFMIAASILAVFDIKKPLDENGNEITPSDQYETGGILHPTPFKCRIIPRNDKAATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C827</accession>
    <name>A0A8H5C827_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C827"/>
    <dbReference type="OrthoDB" id="3026661at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5336301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="517" mass="59152" checksum="831297D1CF7AF65A" modified="2022-01-19" version="1">MSFLQHYTRSLFLRSFSTSSRCLEQLSNLSLPPKPERPHSRVVLIRNFPPTSTINDFLNLRGTNKPIESVIRYPEYNTVEIRYLEPYATEYIGFLAAQSELVLEGQALRVENLPHRPLPVEALAAIGLRAASRTLVLRNLRAHFSQERLEKKLKEKLVRHFGKFERIWIREDGETATVTFHNLMTAVKALKTLHAEGWKVHCKEGLPKLREFPDSAFPTVHLSGLPHGIQPQTVLKNLYDDLSSFPKGDPMRVFTNKKGAFLVFFAPPYAKKFCDIYQPPPGVTATLTNEGLTPQYAERAARRLGASRTIIIDGFKDPAITFDHIHQDFHPFGRVFYVYMDTEKAHARVVFTNISSSFKAIEDIYENRAKYKDYYGARITFGRHKQMAHYPLRPIFIRPTVSSTVNSPSVMQEDEGEEELVDEWWKAGREGREEDIDDTLDRVEEKEQKSESVMDAQKDLGTSTDSTNLNAVEDDYDYGDWQEPEESAELGEVVWRGRLDKPIGRYGFDVSPKSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB16</accession>
    <name>A0A8H5CB16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_012222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB16"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5338421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="43310" checksum="4843C2A17B2A37CC" modified="2022-01-19" version="1">MNYIQLEKLGKSDSSEGTYATVYKGRSRTTNEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNIVRLYDVIHTETKLVLIFEYCEQDLKKYMDQHGERGALDPNTVRSFMYQLLKGTAFCHENQVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDVWSCGCIFAEMISGVPLFRGRDNQDQLLHIMRVIGTPTDAQFQKIFKDSPEIQVKQFPRYPKMDFRQVLPKASPHAIDLLERLLKFDPAERVSAAEALSHPYFTTAVTQTPFGINTAPGSMPPPAFNFPHPHGHQPSQQQQQQQQQQYSRHPNFIANPASVQQQMQAQQAQANMGAFGTMQFHAPYGHNPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD09</accession>
    <name>A0A8H5CD09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000184">
        <property type="protein sequence ID" value="KAF5339514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD09"/>
    <dbReference type="OrthoDB" id="3250036at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="128" mass="13580" checksum="332CCD25C4E562C8" modified="2022-01-19" version="1">MSDEYGRAGFNKDNLADDSANTRVTLDERTKNYPPEGDTTSSGGYSSTSDVWTDKAQRGNTPVAQERDGARQSQSNTNSGSGLIDQSLSGSDLSGQLRDAKQGSDLSMEAVRGGEKRDAMREDLGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD25</accession>
    <name>A0A8H5CD25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000197">
        <property type="protein sequence ID" value="KAF5338287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD25"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034263415" evidence="1">
        <location>
            <begin position="23"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="36174" checksum="7DF5E01D2F7D24DD" modified="2022-01-19" version="1">MKSITATIAFIGLAVNLASVNAIPLANPIVSSASSAIASVVGSSAGSTVTSVVVDSSASSAFTSVVRSSASVPVTSIAVESSASNPFTSIIGTSASHVTTSIPYHSEPTGVTSVVVSPIGYPVSSGVVSSIAVATTSVVIGTSAPQGTTNVTCSEPTGVTSVIISSIGYPVSSGVVSSTPVQVTSVVVVTPSSRPITSVIGTSASQDTTSEVHCQCHSEPAITIGYPVFPGVFSSVAVPTTSVVIESSASRPFTTVIGTSPSQVTTSVPCQPESTGVTSIVVPSIGYPVSSGVVSSVTVPTSVVSSRPIATTSIVSSRPVATTSIVSSAPVATTSIVSSAPVATTSIVSSAPVATTSVVSSVPVSMSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFG2</accession>
    <name>A0A8H5CFG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000174">
        <property type="protein sequence ID" value="KAF5340533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFG2"/>
    <dbReference type="OrthoDB" id="3225557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="265"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="58194" checksum="7B9E75D1C1CF6F42" modified="2022-01-19" version="1">MPMLQKRNAPSASVRSQKTTGPAILKNRKRTMQKSPTAGSKNGKRQGPKEKAISTIKEDKKKVTKHDLRNDDAEMDDPEELDASDYEQPANVDEDSSAAEEDEEEDIDDEELAQETLTVHQRVQVVSSEAKKDNTTVNKAISKHGNFDFVAPRTQKAQADLDTHFPGTEDKLDEEGSSVENVEHPKGSESQERPSKPSKNAKSAASKRVTIDVAQIAAADTRNQNWPVEAHLFYPESGQRYIPLLKQPQHLRLVISETTNISIGIMLFQDACPKSEDQNNYVMLAFKTACNKHDKSLIADRFDRDDKFKQYIIAYINNRVSTIRGRVKESAQNIVPARYDLLKLDETGRSKLVKDLLKACCYIFPLGDSMNTKTWRSNEPYQHPAVVDILKDAFWTDSANHVSLGKKYTETFSSTVDDDSAKEVPKAMLGLIGIAIFAALREYTIGTHVKQNFDLSIMRDEYLRHIRFIEQKIIKDDGSGRKKYHNMAAKLYQQVTKSGEAANEDELPDVDWDNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ98</accession>
    <name>A0A8H5CJ98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000157">
        <property type="protein sequence ID" value="KAF5342765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ98"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5342765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="37686" checksum="EF5561F64AB534E0" modified="2022-01-19" version="1">MQTTYQLSVPLPRALLIHHGKRFTKYSLNSDFYQWTDLIGMTVILHVPLPNDLAAVTPTTPPRAKRAPAPFLSPTENRITSALIAGGLNSDQHSDISSLTTMQGLVAPIPTVSFLDIINLDNVHTRVNRGRYSGVVEFDGIMIEANVHYYAVALMEFAYAYIERQKLEKGLPDLPIPNLRYVEAAVFMVQNNEIRHSRSSTAGPKRTYLLEERIALPPGQDFIKYIHNSSPLPAIPPEHPEYNTALFLAAVQHLQYEKTYQSAYVSDFQGYGGLLSDPQIMTSPEGAEAAALDPKTSLFGDGNVQSGFEKFPLNHQCEGNPFCAWMELKPLQNELQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL06</accession>
    <name>A0A8H5CL06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000154">
        <property type="protein sequence ID" value="KAF5342871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3027520at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="1322"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1720"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1279"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1728"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1761"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1782"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1794"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1809"/>
            <end position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5342871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1832" mass="207724" checksum="27B2D502D5D88C34" modified="2022-01-19" version="1">MRKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPPEEYLGNPDSGEEKDNGNASDMDIDNGELGCPEVRTMPPVNESCEDKSGLQHLPTRRDETQLQTLKLFNFKSIAKAMQPSTIPTDPQSNVIPSKSAVVPSVQSTSHSVGNLQKPLCPPTTVASQTVPPSSSHPPAVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATRNCKGNNGKKNQKGSIHATTIAGGKESYKKCLGVLRCTNPQCQVITRPKIEKKILEAQCLNEYCICGFSLEHFDCGAMSFLIEYAQVGDDITTRLYRYIHAGCHNHPRIPYTKHLTAQEAKDTRQHLGNNMHKKHLESYEGGETLDGPTPPAPQLAQKFANIETYRYETKKNDKRSYSRSWMQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAELVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTAVIEAIAEAAHEHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTVLENAAQSLIKGCRYHFEKSVTRVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQRKMDSKLALKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDRSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMYKSEILIAYEHRNMNIILHYIGYIISFAHEVDQSIQKLLIQRLSSCSEGHYQVESPWTTSSTWQEPAARYLQLFGGRLRTGSSQFSTYPQWRFHRKSRVAGDATQRRAPMIQISIAMGSARKWSLLAGYHLYSSSDQVWMKKAINQIGISLVNYTQAQKPQVQEMEWYTNLWHACSQTKHTFGGQSAVFSYDGMENMGYSQLVKGKIGDLLAGTTGYQPDGYQTVCAVYSLKGGIVAQEKFHEDCVKIALQKLDLQLDGTRSTTLTKPGYREMTREETVNWKPHISITEYQQTHSDSRQVVKPEPAHSYSPSPGPSPTTPLRTIPSSSPPPSTPLPILCRCGVENDGHRELIKQVTVQCDKCHRWSHLACLVNRMEPTIKGEFLCHVCDPASMLDTSSSQIIESLKQGVQLRANVAKRLYAGRTVLVQMDANTLFYYPGRLLHQEKGKWTIKMWRGIKHENANKVLENISVKRLVDGLYGDREGRRSIRLGRFIRTHEERDPADIASDWQVYQYNTEVDRALYKHKAMLQKILHHTINSEFSALSVSSVPALALYLNEGNPGYAIFRNHQYMTAVTLFRRPCPAYFTGGITTDDQARILNWLHINVQSFLSAPPKDFELCIAHARTLFLAHCHRETFLGCIEAGLSELEREQSVLHQAWQRLVDFSGKTVDGKMKRLKADVDREALQILEKVMFDRSQKAGVAGSEQWGLDVGPPEDLWWPYDGPEKNDPDLRVATESDLEESEFCKAEREKMEQKVREKEAEKQNHAPPRPKPRPLTKEQAAERSKKALQEAGLTAERPDLAKEKVVKTLQTVQENAQLRRSKRVADQTKETEETENNKKSKKQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL59</accession>
    <name>A0A8H5CL59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL59"/>
    <dbReference type="OrthoDB" id="3264316at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF182">
        <property type="entry name" value="OS09G0381850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="211"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="303" mass="34314" checksum="D1C168795AC16812" modified="2022-01-19" version="1">MIKRGHTLREGIDHWVFLHAEFRDLALSKSDWKQLEQLEKILGVTLQMSHADTPTIPWVLPMYWLMEYQLCLVSEDMALPLSFREAATVGINKLEKYHTYAKNNLFYVVATACHPAMRLNWFGPPDSDEYERASTIFQHVYEEYSQSTHPPTSGLTSPSKPNNRNLPSNTSFLQSCLTLGSSFNDLGSGTLTASEYDRYTHGDGGAGDIEKLLGWWKEHSTSKEGFPVISRIACDFLAIPSASVSVERLFSSLRHLCSDLRSSLKAETTTSAMCTKQWLKQGMLEFDVRRLISSQTMTQKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLI1</accession>
    <name>A0A8H5CLI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000154">
        <property type="protein sequence ID" value="KAF5342877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLI1"/>
    <dbReference type="OrthoDB" id="3037695at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="30572" checksum="C1420864E01EA78A" modified="2022-01-19" version="1">MFLALAAAETYRQLTEMTIEDMLAQLDIAREQHYLAEDEVNTQVDQLQADFRAMASNIARINAAFRPSVPSPSVPSIPTRSPAHRSNVSRTQPSTPTRTGINQPAARRAMSSAPTSPSLPSTIQSPTEPASSFTVYPGSRKPAYIVYYGNNAQSGFFMLGMGRTSLVPYASAICDPDDRSQVFKGFGDPGQALKLWNEFSQSKAAEVIAQKLGDNECFVLIEGVNPGVYKTRKNLIMDGLVYGGGVAVRYVGDISGAWAHLNKCKRDGRVKKFAARRILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLY4</accession>
    <name>A0A8H5CLY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLY4"/>
    <dbReference type="OrthoDB" id="3341077at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="36309" checksum="5D9F35B59CB52D8B" modified="2022-01-19" version="1">MDTEEVVTQSLASLAVNYLLYGAYLLLFSTCVYILVQRQRRYVVFYLVSMSILFLLATTQTILYTITDLHSLLIELGLRDDVSLRSILQSTIRGLFILSNAMGDMVLLHRCFVVWNHKPAVLVVPTIMAVINNALAIAAVISNATGKYTGSGDSASAAFGGYVMFAFFSLNIATNVLLTLLIAGRIWWLRREVVGYLGSAVNKRYLMTIHIIIESGLIYPLALILELILNSDTGIEFHTRFSILTQVVGIAPTSIIVRTGLGIAVENVNVIPSLELEAASNSNAPDSVISSMVPNSLRVDSFSVVRSIGDSGYVGSSTTATPATDSVNGTVDVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQC3</accession>
    <name>A0A8H5CQC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQC3"/>
    <dbReference type="OrthoDB" id="431454at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12433" checksum="331566B1F7FD6DA1" modified="2022-01-19" version="1">MLSQYEKANFMLEQAKEEFEGLGSKLGAAQCLRSLGDIRKMLGQYGEGMIMLEQAKKQFEEIGDTLGTAQCLKSLGNISKMLSQYEEAEVMLEKAKEQFEGLRSKLGAALCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQJ9</accession>
    <name>A0A8H5CQJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQJ9"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="353"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="651" mass="71754" checksum="AA48A52A247269C3" modified="2022-01-19" version="1">MSVVSDEQFLLLRTHFAETASGIAVYGAYTILLFATTYTIIDQGLRKSKGRRVLLAVIWLMYINATIVGAVYVRFFMMSIDMLQTTKPNPPTEGDFDRLYKLIIPIGDMNYILGDAVVVWRAWVLYPQNPKVRASLAFCMVGTSVATIINAVIGIQEVPYTHEEREGLETLGFFLPLLATNLFATGLVAYRVWQYRMLWSELGKESRIFRNLLAEKALIILLESGILFCVYWVVAMLSALNLVGNLAHQLLGLYLTLVILAVTYQKRIADASTSFDEFSAIDVIASTTRQTRHETPLIFARGQLPHTDEERPVELAQAILNDPKTPDARLILADIVEPAAPSNSDTSPNGNVLTLKVDLTQSSDIDTLFKTKLGVPDAVYCMHGIMSRGSEDKFDFALKVNVDSVRDLLQAARRYGHAAGRLIKFIFTSSLAVYGGPLPDVVVPSTIATPEGSYGMGKLCSELFINEFTRRGFVDGRILRLPTVTVRPGAPAAASSSFISGIIREPMQGLKAICPIGDSLDSSELDIALWISSPKTVIKNLVIAKHIPADKFLSHTRVVCVPGITTTVRGELEALKAVSDRVKLKSGEEVDVLSLVEFRDDPMNRRIVASWPSKFDNSYALNLGFMVDSGGMIGVVEEFKKVLEGRMAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQP1</accession>
    <name>A0A8H5CQP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQP1"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="14788" checksum="5D21E77061EAB5F4" modified="2022-01-19" version="1">MYVFALLDSILESQTEIQDFAPPQELVPVHPVHQVQDWDAPAGAIDWLRLVTFLRQVKETGIIPPDHRSHDHLNVQKQVQLDEQIREHWAKTFQSLQKQVQEKGETIVWGLVDGFLLYWHPVRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS08</accession>
    <name>A0A8H5CS08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS08"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="84" mass="8772" checksum="1A44CB40AF03DFF4" modified="2022-01-19" version="1">MTIASLLLQFGVQLAPSESLITIQSTMQLTFKLRLIAAIAALLFILAQPVLAGCKPSTVDVDQDPPGKTGVLPIFGGPESCSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVZ6</accession>
    <name>A0A8H5CVZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_010887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVZ6"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="173"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="377"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5348369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130760" checksum="DF2A9E75115CA89D" modified="2022-01-19" version="1">MTEPSPSSNNVSNTPLPQPTLATGLAEDDDEPPSSNQRSFINQSHVQSQPNAEMTGEKEKLELEHNDQTITNTNTRPMPTLPPVSASGTVPKMTQRRAPNRQRSGASKRMAPTRMERLKALITPNDTTITGDLMPLPTYTQSLLAAVRYTPLNTFLLFIPVSWGLHYSHQSDTLIFVFSALGIVPLAALLGFGTEQIALRTSSSVGGLLNATLGNVVELIIAGIALQRCELDLVQSSLLGGLLSNLLFVLGMAFVVGGYRFHQQEFQPMVAQLNSSLMTVAVIALIIPSAFHEYLGDRLPQGTELDVLLELSRGSAIILILIYIAYLYFQFYSHKSMFEDVSQTSFSSSSSISTRSVPSSASSLSTIELPRMNFVSAVLLLVATTALAFVTSENLVSSLEGVVETHPEVSKEWLTLIIIPIISNAAEHVTAVVVASKGKFDLAMSVAVGSCIQIALFVIPFLVILAWGMGKNLTLYFDELETLVLFFSVLLVKFSVEDGKSHWLSGVVFVAVYTLIALSFWHFPVTQPVHAEHVVTNRGVSNLDFRAKSYMVERKSCPSSNEAMTINALPRENSWKTANFKRVGAQKTGKCRHSFSYGCHVEWLQILPQLTEITPPALVNIAKDSALPPTTRRHASSAGDTSSNAYCVAIAGSKTRPHIHLACNMARSTRRAESGVGCFTFSIYAVEISVPLAVPRVFFSRKGIKELKLSHSTLTLSLTSSFPADRKAQDVWTCDLDNFLTTTRNMMDDVLISQLPPAILRSSLRALIAQGSAMQRIFVEHVRRRLAESPPKLPGPSELFLGNAPIYAEFLASTRCMFSSKMAQESLPYLTHFLKSILESGVKWCPNDSLELAFEKACGDIVQAVQALKESRPNPTEELGTRLHDLQTALEKCEKYCTNQGLCYPFTRARLQVDDVLSLTFPESAEPLAQTPPNQSRNGSPLPSKFLVKPDPKSTRHIEYVYLGKLKAPRLFNGLWQMSSPAWGSASSNKQELALTQLVKKGFIATDMADHYMTAVCRKYGIKLLTYGSFCGGFLSDKWLGRDAPDIYSESEQLTPSQRKYFDMILTWGSWSHFQTLLLTLSSIASKHRVDLANIAVRWVLERPSVGAVIVGTRLGVSSNADSNLKAFQLQGGEGEGEGGVRLDEEDCKRLEEVALGLSSGVSGLSEAGEGRLGSRTKMVFEKLGDCGHEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CX80</accession>
    <name>A0A8H5CX80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CX80"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034272726" description="Aromatic compound dioxygenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39287" checksum="9DFA87EFD74D6335" modified="2022-01-19" version="1">MFCSRFFHLLALLPLVLAHKEPKTDQEIETQRALQRAAYYCAPAVADFTAARKRKWAQKVLNVNPGLPGYDDLFADANYIDAGESTELMECSPVSRKTAIQNNTCVLTPVVTEGPYYHTEGHPIRTNIAEYQFGLLTYLDIGVIDVNTCKPLPNVLVDIWQANATGHYAGHPFPKPELKDEKPQVGGKRSGLLSAFPRTEFDETWLRGAFPTDENGVVQFTTIFPGYYTGRATHVHVKIFKSWEPLPNGTFSSPEGSLAHVGQFFFEDELNLQIDKMWPYHTNPIKDTHGRTRNWRDSLNIFEDSHSPEGQYNPVFKMELLGPVITQGLAGFITMGINASASYDNWWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZK6</accession>
    <name>A0A8H5CZK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZK6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="506" mass="57627" checksum="6E55DC3EEF902C0E" modified="2022-01-19" version="1">MVYFRNNEMMTPKTIAEERAWILHEALAKAPDNELTRQVHERYYLPAVEAQFHTKPTEVDRQSLSKISSKTNKTATPSTGTSIRSTKKTKQSANTPQSSLPRYNPNGTFVVPVRHVERYRPLKDDLLDDVDRHLKTILGLDETVAYDNEMYDWYRAERFRRESRIGVRFQNAVDHMFRDRKASSGVYKKAEWTPEAFFAIQVPPKKGFAKLKEKLTKEKKEKPRSDSVKGDEEQHQRPAVLSQVIEEVEEEESQPQVAHCKVHKPNRSDDTTSIHTSRMRTSSESSKPLSIFRARAQSSAPSSASIHSRRPQITGPVMHLGNSSVISLADAGSIGHYPTSSTQQQSSRYTEFETPRRPPPIPLYPAGPIATPFPIHTMPIENKKIAVGSTRAPRKVKSKSNENDRNERERPRSRSFSGYANELDTILMEYAKQQEEEALVKGRPPRPQRPVPRAPGSPIDVNRIRLISRRTSVDYGDEDDDDNLDELTREARGVARKVGEEWGYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0F1</accession>
    <name>A0A8H5D0F1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0F1"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="277" mass="30622" checksum="F8D5DBFF652BBD00" modified="2022-01-19" version="1">MDIDGRNPDGAPSQPSAGSGQQQSSVEMLEVEDQDQRAKRFQFMFERMNASSTASRTPTNVPEFKFDFGERKTFAVPPSQLLSRVQAFLPQMEASNALLAQKAQADPTSVDIEHVENGTERYIEMNLGLGVFETKKAPSDEDTEMSSSDSSSSSMSSSDSDSNSATSSTSSSSDSDEDEDEWDPDQILSFFLPSRLLRHNSDSSNGSMDSEEGLPEAKARRLISPLPRRTSSARNREVELLRHQHQREAERQQPSIVVLGETESDSKDWEDGNGMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D526</accession>
    <name>A0A8H5D526_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D526"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="182" mass="20268" checksum="CADC380EA0B127BD" modified="2022-01-19" version="1">MADANVDLNDVLGSILIGTWLNAMLYMLEITQVIHYFQNYSNDRPIFKIAVATVFILDTVCTVAACASAYLYSVVHWGDRAYLAQQYWPIPMYIVTTGTCGAIVQFFMLSRYWILTKRKAVASVIIIGIIVTWGGSIYSASKLATFSDYSQRKTVFVSATSVLKLTLAIVFWILTPGLGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6K5</accession>
    <name>A0A8H5D6K5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6K5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="38938" checksum="2B2EF85B3B38CAA5" modified="2022-01-19" version="1">MNERLGHRQLLSVLWRHRVDPRHMGELPPRPSHSGGKVGSTGLMTVTGLRDWARQGGGGINAEDASSFPHRPSSPATDLANAMNNTNLASAYAKNATNLKARFNDVFWMDNVGLYRDNSSTTLTPQDANSFAVLFNVTNTLEQKKRVSDGLMKNWNALGPLPPELPDTISPFISGFELQAHFEAGNGDRAMDLLHRTWGYMLYTNLSVQSTLLEGFTANGSLAYRANVGYNHDPAYTSHAHGWSSGPTSALTIYVLGLSVTAIQGEQWLLAPQIGVGGLTEAEGGFETQLGWFGASWSLGLDGSDGLARVNVTTPQGTKGVFRLPNVDDDNVPVPQVTVDGKKATVVNGQVALSGGSHVILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCF5</accession>
    <name>A0A8H5FCF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000325">
        <property type="protein sequence ID" value="KAF5331482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCF5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5331482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="118" mass="13300" checksum="B595CD830649E312" modified="2022-01-19" version="1">MSRLMLNLHEKANDGIYTTDHSTCEFAVRTDLEQPDFVNFVVDLDVSRDADATTGGGGERRRFEDEDGLELGEEYKECCRTRTRQGVQVSVYSVESDWNHWTKSDLAIDRPGQGPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEY1</accession>
    <name>A0A8H5FEY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000271">
        <property type="protein sequence ID" value="KAF5334077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEY1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="23057" checksum="E3518C59D9AAF7E7" modified="2022-01-19" version="1">MSETQAFGFSGCYAFAADSNTVKRVNGPKITMGNMKPKARQTGFFTEAAEFVNKLKKGDKVKTHTSLLAGQDIFYQNCDHFAVRDLEVANLDYEVEFAEDTSPEIVQMILSHLAEQKSAQKDPKPQRSQREDQLMMFRPGSTQRPISGLAFARCGAVRSPGRTLEPSVSPTRPRLGTGPVEEEEFEDEYYYEACEGTSTQGEVRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF43</accession>
    <name>A0A8H5FF43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_014833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000266">
        <property type="protein sequence ID" value="KAF5334168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF43"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034584284" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="12">
        <location>
            <begin position="450"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="13">
        <location>
            <begin position="715"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5334168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="100216" checksum="BDD4B7E8A1D2BD2F" modified="2022-01-19" version="1">MTTSTSLRRFVALLVIAAVAPCLALIHDDSSTLHKAQYDFVVVGGGTAGLVVANRLSESPEVSVLVIEGGVSNTKDALNIQVPFFCTKATPDTPFDWNYSTTPQEALLNRSIPYRRGHVLGGSSSTNFLAYNRGPSDDWDRIAAFTGDDGWSWEKLQPYILRNEILTRSMDGHDISPQIIPSVHGHSGMNGDSLASYPTPLDNRVIRTTEELKHDFPFNHDMNSGFHLGIGWQVSTIRNGSRSSAATSYMASQYANRKNLDVVLNTKVTRVIPEANSTTFKTVEYVSTSGQKNQVTAKKEIILSAGSIGTVQVLTLSGIADPENLSQLGIESVLNNPSVGQNLSDHPIVGQSWFVNDTHTWEAAARNATIAAEQLREWKTSRTGPLTDALGNHQGWLRIQKNSSIFEQYSDPSAGPDAAHYEIIFANGLNFATPPPTGNFMTISTVVVSPLARGSVHLNASDPLGNPIINPNLLGHDFDMFVMRKAVLSARHFLTAPVWSDYVLSPLVNATTDEEINAFIRNNTRTIFHPVGTAAMTSEHSGYGVVNPDLKIPAEIAKIAGPLVIGYILNSVLYGILLLQVYMYYMAFPKDRLVLKMLVYGCFILDTAQTVMNIADAFSIFGSGFGDMGNLRKMHLAGLSVPIITGLISCAVQNFYAYQLYILSNSRVLSLIISSVALVQCTGAVVQGVFAFKIDNLATLQSRTFIECTIWLAGSALCDIIIAVSMTLFLVKSDTGLRRTHAIIRKLIRLTIETGSATATVAFIDCVLFLTVQSYPYHTVPARCLGKLYSNTLMAILNSRMRIPGSREDPELHSTSIASPRDYHCYDDPWGTIDLNFTTMRSRRESSNRGTFSLSRTGQGRSDINTMSMSMSAGSIDVTDGIHVTKETWSRSIPVSVLTSKKGTRHSVAIRESMVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHQ9</accession>
    <name>A0A8H5FHQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_013006</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHQ9"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034643647" description="Chitinase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="12">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="92"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5337675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59134" checksum="FF187932BC117FDE" modified="2022-01-19" version="1">MCRLLIVAIALIAQTAYGQNCGSQNNGALCPTGQCCSNAGFCGTTAEYCLTSQRCQAQCINDGPPPPPQGPKPPSIDTSKLFKPPDNTFATKQLVGYFSNWAQYRGLDPSVPSCDKNQSFLPENINPFLYTHLNYAFVFMANNNSIVPHEYDDLDLSMRFNKWVKGLNPSITTSFSVGGWTMNDGPSKFTGNIDYSTFFSQMASTSGSRSTFIQSCIKWARDLGFDGIDIDWEYVGDPTRGGTSADTENFTSLVKEMRDAARAEAASSGKNELLITVAAPADPDKFNLIQAKAVSDQIDWYNLMTYDFYGNWDPRMDSQAPIADTLQKGWSFTSAIDLYLNAGVPGSKINAGIPLYGRIWTIDDPSCTSPGCTGTAGISGRCTAEDGFLAYFEIKEIIDALGSQNMLSTAVNFASQDGYFLVFDDQWVGYDDENSFQAKVEIINNKGLRGAMLWAVDLDTTDFALTKTLLEYYPTCPKDGDWAATSANSDAEILCSSDSAFPQETQMRRCNEDLTWGVVDNSACNPVRPVSLAAQKCIEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIC1</accession>
    <name>A0A8H5FIC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000204">
        <property type="protein sequence ID" value="KAF5337874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIC1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="13034" checksum="CF340F6E9F91EDB3" modified="2022-01-19" version="1">MPLRRRRHLNLSCYTGRLELVYEITTAGFTIQLTYYVHRVASRTPGVSDSDLSSVLAPQQQKQKHDSALEKKSFQTNINTIAACKGGDPVSHSLMDCLERGLRVQVLVQNRDQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL92</accession>
    <name>A0A8H5FL92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL92"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23049" checksum="2F99B5E7DCC2E9AC" modified="2022-01-19" version="1">MLIGMSGTVFGYILIGAIEENTPEETYDQFNTNVFGALNVTRAFLPYMRQRKTGTIVWMGSVGGWRSGSTCGLYCTTKYALRGISETLHDEISPLGLRSTCIDFGYFRTNFLNPGHKAPYESSIEDYREMVKKGVEALEAYNDNQPGDPVKGVQIIIDVMKGEGVAKDKPFPKSLQLGTDCYGVVKNAAEETLRNLEAWKDVTCSTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLN4</accession>
    <name>A0A8H5FLN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLN4"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13794" checksum="E0620567E602D751" modified="2022-01-19" version="1">MSTSSAGSAQPLKVTPSTPAKYAPASNTENDADKTPSANKSTTAAKPNMGLNNISSPHELTAFVENLLENLDQKFDEMSSQILERMTQMSSRVDALEAAIQDIINGDVSGTPSVPPSPSPTAAISGGRKSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FND1</accession>
    <name>A0A8H5FND1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_015205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000148">
        <property type="protein sequence ID" value="KAF5343151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FND1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034385117" description="endo-polygalacturonase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5343151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="37723" checksum="AB3AE8258831B4AB" modified="2022-01-19" version="1">MKSLTTLALLASLTGTLASPFNSTRRYPQKIGKRCTGTISSLSDVSSAQECTTVVINSFTVTAGQTFTLNPADGASVTLNGDVTFGFAEWAGPLMVVEGNDITFNGNGHTLNGLGAQYWDGQGGNGGVTKPAPLLRINHDGGTFSNVKVLNSPGRAVAIGGDGIVVSEITVDNSAGDAANSKSDGKPAGANTDGFDISANSVTVQNSVVMNQDDCLAINRGTSITFQDNKCSGGHGISIGSISSSVVVSDIHITGNTVTNSMQCFRIKTDATATGSSVSGVTYSGNTASGCEEFGVLITQSYPDALGTPGTGVVISDVTFSGTNTVSVNSAADRVDINCGSTSSCSGTWNFAGLTVSGGKAGTVKNAKTSGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ45</accession>
    <name>A0A8H5FQ45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ45"/>
    <dbReference type="OrthoDB" id="3008788at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="37253" checksum="8C87C152B279A72F" modified="2022-01-19" version="1">MSSSFTCHYPYYFSLYSIRSFTDSLSGVLSIFASVAILLIARQIVKQNFEKTPCNHPRTDELMLRCQQLEHQLAVRDSQYEDLQSTTATSHAKYLRLEKHYISNEERYRGQCEELEQRNTLLKSHYEQRRKDFRLLPITLFTERLILANKMWQQKKVTNETQNQLVLREKQVNRNAFEAFGDKLLLSNVIWRQQTELKGLREEVEKLKKGRIRAISSQAKRMVVDTRREGMVGELCKDLTREVEEEKRKVVELQEQHGKEVKSVTAEWETKYRELLREVECLRLGQEARLIEQEISNDMEDRLRSRIKELEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ55</accession>
    <name>A0A8H5FQ55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ55"/>
    <dbReference type="OrthoDB" id="3000408at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034076468" description="Cysteine-rich secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31012" checksum="444D53BF57D80627" modified="2022-01-19" version="1">MKSFFTTFSTVLLFSLAITVQAQDDECPDGYEAVESPPGSGNIVCEKVNIVCPGTGRRDYVDKATGQQLCCPSSKNLVILDNDRDGVCCDMSQIVEDGQCVTPSTPGGGSGPQCPRQPAGACALKAACGNSTNNGLEYGSCYTLAFPDGHQLGRGRNGANNEYIEDGYVQDIPFKVCKSTTDCGTGSLANGDSFYLQDLVGDPGDATGKLGWNNAAGGTHLTMTPDPASAGQFKGKSSCSGTNCKCVVKLSGNPNGLGYACPAQQPGITFWPNQRVTLNMQFIEIPCTNADPAPQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQJ3</accession>
    <name>A0A8H5FQJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQJ3"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="182" mass="20238" checksum="4F2749F1CBF04A43" modified="2022-01-19" version="1">MNTSMAPPVSIPGKSLKPMVLKFQCGLQPTLEKKVAEAEARPQEWDVMALYSLAKRFDKHEWEDVIFCGAQRSGHSLFPIQFPAPNPAPCVPAPAQAPLPQGIPMEVDTSRQRFLACHTCYTCGKTGHFSAACPDCQCEHVCIMDMSVDDWQEITEAYTAFQDFQAAPTNKPTQEDFAKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR49</accession>
    <name>A0A8H5FR49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3056903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="1295"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1674"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1681"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1701"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1734"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1755"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1767"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1782"/>
            <end position="1797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1805" mass="203771" checksum="9CF171FD54A0DD2C" modified="2022-01-19" version="1">MLLKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPPEEYLGNPDSGEEKDNGNASDMDIDNGELGCPEVRTMPPVNESCEDKSGLQHLPTRRDETQLQTLKLFNFKSIAKAMQPSTIPTDPQSNVIPSKSAVVPSVQSTSHSVGNLQKPLCPPTTVASQTVPPSSSHPPAVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATRNCKGNNGKKNQKGSIHATTIAGGKESYKKCLGVLRCTNPQCQVITRPKIEKKILEAQCLNEYCICGFSLEHFDCGAMSFLIEYAQVGDDITTRLYHYIHAGCHNHPRIPYTKHLTAQEAKDTRQHLGNNMHKKHLESYEGGETLDGPTPPAPQLAQKFANIETYRYETKKMTKGATAEVGWSFINQFHSWIQQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAELVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTAVIEAIAEAAHEHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTELENAAQSLIKGCRYHFEKSVTRVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQRKMDSKLASKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDRSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMYKGSQAAVKAITKLRVLGPHLPPGKSQQQDISNCLGGRLRTGSSQFSTYPQWRFHRKSRVAGDATQRRAPMIQTSIAMGSARKWSLLAGYHLYSSSDQVWMKKAINQIGISLVNYTQAQKPQVQEMEWYTNLWHACSQTKHTFGGQSAVFSYDGMENMGYSQLVKGKIGDLLAGTTGYQPDGYQTVCAVYSLKGGIVAQEKFHEDCVKIALQKLDLQLDGTRSTTLTKPGYREMTREETVNWKPHISITEYQQTHSDSRQVVKPEPAHSYSPSPGPSPTTPLRTIPSSSPPPSTPLPILCRCGVENDGHRELIKQVTVQCDKCHRWSHLACLVNRMEPTIKGEFLCHVCDPASMLDTSSSQIIESLKQGVQLRANVAKRLYAGCTVLVQMDANTLFYYPGRLLHQEKGKWTIKMWRGIKHENANKVLENISVKRLVDGLYGDREGRRSIRLGRFIRTHEERDPADIASDWQVYQYNTEVDRALYKHKAMLQKILHHTINSEFSALSVSSVPALALYLNEGNPGYAIFRNHQYMTAVTLFRRPCPAYFTGGITTDDQARILNWLHINVQSFLSAPPKDFELCIAHARTLFLAHCHCETFLGCIEAGLSELEREQSVLHQAWQRLVDFSGKTVDGKMKRLKADVDREALQILEKVMFDRSQKAGVAGSEQWGLDVGPPEDLWWPYDGPEKNDPDLRVATESDLEESEFCKAEREKMEQKVREKEAEKQNHAPPRPKPRPLTKEQAAERSKKALQEAGLTAERPDLAKEKVVKTLQTVQENAQLRRSKRVADQTKETEETENNKKSKKQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRX5</accession>
    <name>A0A8H5FRX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRX5"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="542" mass="59025" checksum="3C280C2FAFB52FC1" modified="2022-01-19" version="1">MTLKELAFAQGRHMYPSNVSTTYISILDPAGKTFGDDGKITEFEPVLLALPSLSPALAVEVNAFASSDYPLVFKLPLLVESITYYKLDILKVLPYGLTFHRIIVQADGRTHDIVIGPEDPTGHVTQKYTNTIIGRYANRIPVGKHSLERNGYKAEFEAMANGGLFLPKTSFVFWFSRNTETHHGALTENPRVSLHGGPQGFNTRTFSLIDISISSSAPPTLFSKAELARLTASSSNAEYPSSFALFRHTSPSGDQGYPGTLLVEALIALIPPAHRPMTYLKPGESVEESKTESALGSIVYVYRAKLLDGEVTAVNLTNHWGFNLDASLNKESTELADVKGHTLLMKADRIVARDADSLNTGNFISTSSAAEHNHNGKKIGEGYPEAGYDDYYVFQPQTVNIPKRVSISSLSSSDFDLVKDLLTPAIPNQAAQGARSPTVVELASTKSGLKLSFDTNQSGAMFYSNGLSNANSGARKKIHGGSGIKDHGDAYTPGTAAFLEFHDILSAFLDPSNKDKEDTLLTRDELYNNYVRCDVVYRAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSR9</accession>
    <name>A0A8H5FSR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSR9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="69" mass="7603" checksum="C9C849260290A6CE" modified="2022-01-19" version="1">MSDRERQQVRNKSTYAGRRVSEKISSPGLLYATGLIRQGDISGMQLPLDTSSPIPSTSTTPRSRPHPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVE7</accession>
    <name>A0A8H5FVE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVE7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="31921" checksum="86F954611E6346EF" modified="2022-01-19" version="1">MSPLTNTPDEILLEIAKNLVAASNNYSTWGFGWDAYYPPTAFTRQDPQDRVHGPLIVNDTRRKKLHLKHSETEHVLAATCTHLKNVCFSTMFSRLYVNLHHTQELTTSACEELGKLLKPYQNCVRQLFIAVPFSVSWVVDLVGMLPKLTCVAFPGLCDVGDWSKYQALFDACNSHPKSESLVLRFKVLICDEVAPASPAFSLQRVHLHTLELHRKGPLNTELDYLREWMPWLDAGIQVYTLKLRGLCLLDCSSLKDLTLRGLTKMWVGLNPIFSQLFQVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWV4</accession>
    <name>A0A8H5FWV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWV4"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034400702" description="Peptidase S53 domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="775"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="851"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="855"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="1047"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1088"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1089"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1107"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1109"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5352136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1128" mass="120126" checksum="186ECF7E4E4BD7F5" modified="2022-01-19" version="1">MMRTSLALASLLCSIFLSTAARSEGLGWHFVQTGSTQLTAAQAMVVSPSLVVIFDRVLGDPLQINGHQAWGAVWNTDANNVTAIDLVTDTFCASGGFLSNGTMVSVGGNPVEVEDGQVDPAPDKDGLVGLRIWEPCGHPAGLNCTLFENPDTHSLAEKRWYPTSLRIFDGSLMIIGGIKENTTFFNDKERSASSFEFFPQKDGGVPRPSEFLDRSLPANLFPRSFALPDGKIFMVANNQTITYDIEEQTETILPDIPNGVRVTNPYDGTATLLPLSPPDYIPEVLVCGGTNTTDQLTNDDVYTLSSQDPASDQCSRIVLTPEGIKKGWEVDFMPEARVMPEMILMPNGKVLIINGGGTGYAAVKQVRDPVGQSNADHPVLTPVLYDYSAPLGSRFDREGLPTTDIARMYHSSVSLLPGGNIFIAGSNPGNGVHFNDKFPSEFRVEYLNPPYMTVARPSMSNVPEKVAYNDKFTVDIEIPEGLNTSIQVSLMDLGFSSHAFHSSSRLVFLEFTLSEDKKTLKMTAPPNNRVYPPGPAWLYITVDDVTSNGAQIMNVAVWLPGTMVHLLTFAALAFAAFASVTATPARRAMAVAEQRQVPVSFARAGKPDAETKLDLRIALRQKDMEALEKALYDVSTPDSSLYGQHLSLEEVTTYATPSEESVNTVTQWLQGNGVTDITLSGPFDDWISFRVSVSKADELLDTNFENFVHIESGERLVRTLQYSIPQDLLPHIDLVHPTTAFVRPLAKQPVMSVPIPGSANLTERALGAPDDCNGLVTPACLQSLYGIPATPATQSSNMIGVSGFVNQFAQNEDLRNFLGSLRPDMSPDTTFTVQSIDGGVNTQGPGLAGLEANLDVQYTLGLATDVPTVFITVGNQSSDGAGGFLDLIDTLNAESAPPQVLTTSYSFDEGDLGSALDNRICNAYMTLGARGVSLLFSSGDGGVSGGQPQSCTSFIPTFPGGCPFITSVGGTQGVDEIAADFSTGGFSGVFSRPSYQDDTVSAYLSALGSTDSGLFNASGRGFPDVAAQGVNIEIKSGSRTARVAGTSASSPIFASVIALINDRLVAAGKPVLGFLNPFLYANPQAFFDIASGSNPGCGTDGFPASSGWDPVTGLGTPNFAVLLTAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXY2</accession>
    <name>A0A8H5FXY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXY2"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5353054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="473" mass="52663" checksum="C1735B4FC2392B64" modified="2022-01-19" version="1">MRAPDHWSSGSSSSSSPSPPMPNNRQLPNVDQGENSSNNGETSRVFRDVFKGRKCWKTQKGGEMVWPPELEAALLEGLAKYQPDNSRETVLLGRYPMRNRFISEYILRATGKYRTAKQVGSRLQQLRDTCNAKELQHLLSPVRKQNAPISNRVQYSCLKRYGLSDASPSLSDASLPGSPNIQANESAPRPLRPVIYTYDIVPEDHPSTMGSGASNYLSATSRGTSEAAASPVPIRAVDPTLTFTSASALPTSEIRSVFRVYQNDQHPEKVWKSDISALNPLDHSQIPYAVPDSTYMYKTSFSGGLWDAICQSEDPTKLTVYHNILRDNPNSSTPFVLFSAVYKFRYSYPPSHSNLRASAQGNGLGTLYSMETNSETSVQPTVNQDYPQNLDFFDQMLSSYAGYDFSNHDGWSGSVPTTPSGSEENYNRTSPPYYRDNPERFSHCRAGYRDDSSDSLSPVSTTFPATYMNYRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYH0</accession>
    <name>A0A8H5FYH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_010555</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYH0"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="407"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="336"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5353846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="515" mass="57100" checksum="5E2FA945EDFFC2D8" modified="2022-01-19" version="1">MGSSTLSSPSPSKPPPIWWSQGIIFISIHVAAIAGVCYFPPSVVSWWNLVLMFVLWRAAVFGVTIGYHRLYSHRAFRASFGLRVVLAAMGAAAFQGSIKGYASSSSSYDLVHDPYPATRGMLFSHMGWIFFNPTFEKMKLVDKEDLDNDSVVRLQHRYYVPLALFIGFVLPSSLGLLWGEPLQAFIWGGLVSKLFIWHSILLLNSLAHWNGHQPYSDEDTSRGNLIVAVLTGGEGSHNFVMLGASSLEAANILIAPLHTTPSAKWVLRCCYWHLVSHISLSLHTFPHDFRSGPTLFSWDPSKWFIYILHYCGLITGLRRAREKDVNEARSYMTYKETYGVPPPEDSEEEDFEFSSVDHSGTQSDGDSASSHDEEASGSGSASGSSSRSSGSSTSTMRTRSSNGRGKWPMWTMKDVEEYVDAKQGRCVLVIGEWVVDATSYLGEHPGGGALLRKYAFKKANPGSGSDSKLNPESQWPDSTWAFEGGLNNHSRTAVRRMKDFRLGRYHTKTAAPDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0D4</accession>
    <name>A0A8H5G0D4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0D4"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5355273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48715" checksum="C0C911AE45FBC3D4" modified="2022-01-19" version="1">MSDNSTVLGVVILARHGDRQGFYQDPNTYSATDTEITPLGEKQEFQLGQLLRSIYLDSSSPSVISGINSTIANSTQLIVRADAGDEGGVIFKSAMALLQGLFPSNSNDSTTLANGTTVTAPLDGYQYIPIESVDTDNDISLEGWTQCPAFDKSTQAFYNSSEFQKKANESSSFLNQLPQYLDGRPVTLQNMFNIFDFINVQNIHNARFHQALPDTFLRQARDLANYHEYGVFTDPDVAGIGNMPFRAALPSVLNGLADIKNASQPVKLVYQSISYKPFLSLFNMTGVASMNSSLAGIVNYAAAVALEVRQPSDGSEPVLRFKFKNGTEEPDFTTYNFMNTTGDVKLSSFVDFMTPNAINSTSEWCTICGNTNSRGCDAISAANAQGRAAAAVHQPISPVGAGFLGAGLTLFVVLCMLGVMFFLGFLTIGRGRSRQRGRGGITSEPSSGDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G193</accession>
    <name>A0A8H5G193_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G193"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034232423" evidence="2">
        <location>
            <begin position="25"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="679" mass="70385" checksum="1C6E59EAA47D5DE3" modified="2022-01-19" version="1">MYQSSAMKLLGFATLLAFSVPVHSANDWSVPCLNGTCEYDLPSTSGASGSLQVWGAISDITTAAGWEILGCSSDDLSQDIRLVCMNNSTSCDHLYENGGAEGKLVRLPENCGKSAFARVARAWVPDDQSIPSNIAARIVRRDGSSPQVKALALDTDFSGASAGPVGFRVAGVNVPGVDVSAANAATPHLRRRGLFDIVSDALSSASDATDFDINNSTQLEPFDIDKSFNLLNKSLSCGGVDATLSVDVDAKAHVTAAVGLVASGSIFPPDVKEFALTTDFSAKLNGTLNLQGGLATSFDSPTLTLFEIGIPGLDFPGLFSIGPNFQINAQATADLSIGADLTVGLNYEIKNGHLVFPPSGSDNSSDDSGAKGDQKPSNKTEMGMQQGMGKGAMDDNSTSSNSSGDFEIQDTPLQLSLSPSVEANGSVSAHLIPTLNLGVNALDGLVKANVFLNLDTSATLALSLEGSAGDIQVGKRTPTPPVARAPIVKSTSIPRAVAAAKAAREAEEFYRRTANNNSTESGNSTESSSKSNSNSTDVSDSSSNSNSTQSSSDDSSAGFGGCLQVLAGLDVNAGAEGNLFDLFDDSTQVSLFSKEFQLFQKCFGNQADNKQRRSILSRRYLPESGFARRANETDDGSGNVALAAECLASAVGAPASVVDTAVKALDILSNTKSKPSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1G2</accession>
    <name>A0A8H5G1G2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="738"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5356538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1529" mass="171097" checksum="44AED961CCFE5EDE" modified="2022-01-19" version="1">MRKDLFSIPVVAGTTPAFGPTRPKHPKTKSTPFDVQVSLKKKQKDEAITERRGRASRSSTSRTTSPSPARRTDMETDFPTNDKDSEQREILETPRAHRTRNLLATQDAEDFCSLAQRLISLTDSLSAHCPTSQVPSVNKYAEELFETLAQVLGKAQQKEDKNDLQKLVLSLSTSISDLNSNIARQQNETSDFRKELRQQTCVIQELHQKTLTTNTPTPVPVSSNSYASRTQAAAKAPTHPASAKDIKVKRQEDDRKNRLVIHFAGGSPEPNNRRSNLQIITDINDILSRRPKTNGLKVVSISWTNNNNAVLNTLPNQLGSDLQNFAPLFAHVYSTDDISATDSAPDQKWAKVTVHTVDTGTNDLGRLRTPNEMRQHLLDFNPILQELDIDIRMGPRFLSPPGDVLHKAESSIVFAVTDPSQADYIIKQLGGLNMYGKRCRVQEYTERKATRPCNNCQAYGHSEHGCKSAPACPLCGANHTAIAHQRSCQKCIELANHLSITLDDDSIRNGVTPTCTHNLDCINCKRSGTAEIARRHRTTDRNCPVRIRHVAKTSPRLQQTPTRPPMSQLALGEEITHQTANPKISNKQKKKAKKLQKAQLSATPISSSNPFTPLETDADANSSTQTDDDNLNANKKKNPILNLLNNHHENFDIIFIEEPNWEFTGQIDKQVILGTVNHASAWTPITPIPAAPNDKAPRVYAYIKKGIDAEVTLRTDIICDRDIQILDVTTPDGTTTTYVHIYNDPTLDRQQILWRLRNLDLPHHRPMVISGDFNLHHPGWWADGQRESTLAQEIVDWLVDHKFLLLNEPGVPTHHPHDRKKRATVIDLTWANALAIEQDIVKEWSVDDSIADTSDHLALKWMQDSTLVELENITGKKYSLKDTKEKDWLAAFEDELFSNELHILSDDPTNIPTREQIDLAADALVNAFQQANQKTGKLKKPSAHAKPWWDETVTAAFNRVQLAKRAARRSRLENGHVDYILNEVANHEARHTDRLLRWKKRTFAQDTLEKAATNDIYSFRKWSAGDRNYPTPAIDRPGRTPATTHQEKCDALRNELYQPPPQLPDEYHTDFTPRADDLPCPDVTETEVREVLEETSNTSAPGPSQGYFDFVNHGRLIHQMRSRRVPVELVSWTESFLADRHAAICVDGKVSAMEPVANGVPQGSPVSPILAAFYSSELLELIENDSHPPSFTIPAAPAPPPVMPYVPSADEVARKEAQKAKNLAVSPTKTSGFMYVDDGMIFVSSESPSHNTAILHDVWHRVIAPWCKHVGLTIDVAKRELMHYRKPRSKANPIAGNPRPPLLITDPDGVLRMVYPSTSIRWLGVIMDETLSFNFHVKHLITNAGKALGALFMLGNTRRGLSPYHMRLLYVTCVTPVMTYNRALRLICASFRTTPIDAMEVEASIPPIRITLDGLSHACALRYNKLSVTNPVIQRLPDWHSTDRTITRARGNVPPTSAKLQNSQAPTTNEFPHSPPLRGVELHPTSIPGCALNRPHQNQRMKMYMASPAQAQDSLLTTLALSVSHVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1K2</accession>
    <name>A0A8H5G1K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1K2"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5356621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122969" checksum="DB1AFF25961EEF49" modified="2022-01-19" version="1">MPSLSEVLEQKFTEIVGQLQSLPAYADALFNSDELDDRLLLQEKLLVLMTRLGDSSSSEREREIAQDLQAFVIDFLYKDLPHPPSAYLSALVQPDPSVTTATNPNEGAYVKYAYRAADGSNYNPLIPRFGAAGQPYARTVPSTTLLTPMNTLPDPGLVFDTLLKRPKGEKGNKPHPSGVSSCFFALADIIIHDIFNTNRTDWSINNNSSYLDLSPLYGSSDKQIDAIRRKDGSGMLWDDVFADNRLLFMPPATCALLVLFSRNHNFIAEKILSINEKGNLVSPSKLASNPDKLKAQDDEIFQRARLVNTGTYIKIILGDYVGAILGQVRDGKDWRLDTLAQSRSMSHDVSPRGEGNVVSVEFNLLYRWHATLSETSERWTENEFKAALKDAGLVDGKSPIDYAALTPSDFGEAAATLAKKYRMANVREWTFGDLVRDKETGAFSSEGIAKILMDATDDVAGAYGARRIPEVMKVIEVSGINQARDWGTCSMNEFRKFFGLKPYKSFEEWNPDKSVAEAAKALYRHIDNLELYVGLQAEDTKKPGPGAGLCPGYTISRAILSDAVCLTRGDRFLTTECTPYNLTTYGYRMLLPSTVTEGEPDGSFGGNLTRVIYRHLPAQFPAGSAYAHFPFLAPQFFKKQMEVSDKAAKYKWERPSVPKGPAGYSKNKEGSESRAGYERVIKSYNAAKQILADTVPTTEKDSEKDSHGHAKIWSSGYEERIRNILGSAMPNIQIEKVLVENYLPRDSGLFFFLQEGEQFENLPDYFEDLVKRLVDEKAFGDADGEAKAEENKEGERYLDLMKDVINLIPVRWVFEQLVGIDVAKDGLKRDDNRWTEEELMRRFGDVCEYIFVNVSPVKDWQLRESSIKLYKYFSSHVIKLLDSRESWIRSTVDQLTGHPNKPTSRAFLDKLWEKRGTRASHELAEALFVETVITARHWSQAVGHVVNVLLPETGEIQSKKVNTSVAHIKKVLGDDPIVSGVYRTALQDTTVPGLSEKIVMGERVFVSLIEANKSRPKDAAGILGVGEFGLMSSSFFDAVTPQVIQTILSLPHLRRAPGQSGKFNRFTEKTYTLNGAPQQIYIDTVGALRPFPDSLIIQYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2Z8</accession>
    <name>A0A8H5G2Z8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_005952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2Z8"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="111"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="372"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5357405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="433" mass="49429" checksum="733D25CF1C2D3340" modified="2022-01-19" version="1">MRLLKGTVFCSFFFTSHHPSNMFRTMTDKIGSHFQVHQKDYLSHLSDSPISPSIASTQSSYVTSILPHYDHRGSFSTARTSFSELSKRGDSLDCILEGRERSRASYRLDDFIINRTLGTGSFGRVHLVRSKHNLRFYAIKVLNKQRIVRSKQVEHTNNEQAMLFSVKHPFIINLWGTFQDHTNLYMVMDFVPGGELFTLIRRSNVNKFPDPVAKFYAAEVALALNHLHSQDIIYRDLKPENILLNADGHIKIADFGFAKSCTSVAYTLCGTPDYLAPELCQQLRYNKSVDWYALGVLAFEMLTGLPPYHQPDANPVVLYEKIIAGPTNIRWPSVITDNAKDIIMKLMEVDPSKRFGNMRNGSGDVFSHPWFREVDWEKLAMREITAPYQPTIEGEGDARAFDRYPEDNVAASYGLPGPDPYGYEFPEFTYAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3N8</accession>
    <name>A0A8H5G3N8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3N8"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="479" mass="53606" checksum="D31D4C3A2726E8F5" modified="2022-01-19" version="1">MWLDLGKRIYLHLDSLNVKWTSIDPVCFAPVRFTEEGEDQISPLHLWVGVTPGSLLFEAAKAAAEGCKDILAQAGFPDIEVAFRESVVTWSAGTKFLDVDTIPINPISDLRSPFTPTLGIHISPLKTPHYEGTGAIYIRESSTSHRIFLLTARHVVLPTSKHPNRPYLRNNTSQPHEQVIILSNKAYNEATTHIKTTIGDQQLEIEIYKARLEKLGLAVEGEASEETQLREEYERLVVKAEQTIKAATMLLDEAEKHWTCPNQRMLGYILHAPPIDMGVGHEQFTQDWGLVELYNNKINWATFPGNKIYLGHTISPADFIRKMNPHPQGQSRFRYPTDGMLQIKSIVKDNEIRHSMELDSNGENCFLVVKNGASTGVTIGRATGIKSFVRHNNDYGIEKTSIEIAVYSYNKKDGAFSAPGDSGSIVVDGEGRIVGLLTAGASRTSTESTDVSYLTPYWWIEEQIKKEFPESYLYEIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5C7</accession>
    <name>A0A8H5G5C7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5C7"/>
    <dbReference type="OrthoDB" id="2525765at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="725" mass="81400" checksum="ADC8C3B68A1C833F" modified="2022-01-19" version="1">MSPESSTGPLEITIQPRWKKPPACDYCRTRRVLCHPQPEGRSCPRCLEKGVKCTTTPSVRKKRRRQHEILAARKEDDGGTSQGQELAASRALTVTTTSAAQYPPRITHMLATGADLNDVYRRPIAFAPVSSRPQLQLPKRLMQDLFNDFFYTPCCLHPIIPYYRVRARLAGCGWQLSSLSPQECVLVHCIFALASTVSIDPLIIGPEPFPKECINILSIINPVKFIKSDLREIGRRRESVGLCQQLRAEALRQAQNEAITVWVSPENAASCLLLDALLSQYDGPNCYGAAFTWQARKLAESWYKQPQLYNWAFGTIDLSVRWTAFLLADMLAALHSDRSADFSASDEQLICGHEQLSLEKLESFLSQGCNSWQFYGYYISITFQITRLAREVYERIRGPYTRGRPYDLQLIKHYTASLHLLHDVYNALHKQGVLLARQNQSQKFAILGIVRTVSIGWTNLTLHFYKTMKEMLEESSVKDLYYTTTSGGPWHGHGINIIDGLDGLERGTYSYSSSLAELELTPIFLAVRTLTCKAAIDHSEMIEDIYSISRLTQTKFVGGDLKRWVEFVIDVTDSGIMSASEGIQTLERLRDGLKIAGFTWRTDTDLVEVIDSHVSALMDSSSASAQDPPHMHIFTHDNPDLNYHHTHLNPHPDLAMGYDPDIDSFRNLEINSISGHMHVPPPQASAGVPPGPGPGISPYDHDHDPLVSGYTYAYASTRSSDFFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5K8</accession>
    <name>A0A8H5G5K8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5K8"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="202"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="363" mass="41718" checksum="4A5A74C1519CB19F" modified="2022-01-19" version="1">MLTLFKPWRSGSDLKKVDQTWDSAFVNHQFTLLQKDLMDNFELRFECLDSRDDYHAQRKAQSMEIDPTFLEPEYDDGVHFDPFKCSDDGMVVREQRRQLEMQEMTDLLVNMGWTNAKCDLNNQVPAPFDYPDKNAKAWKLEIAQMKSQVISNRNKNNDQSSHKFRNKYPDQVEILNKYAFEEKFRSTQTRNLIYELCIEYELNPEQERAFRIVANHAVSKIPEQLKMYIGGMAGTGNTRVLVTLKQFFAKRQESHRMIAVAPTGTAAALLQGSTYHSVFGINPKEEGEFWNMSVSQICSRLNGVNYVFLDEVSMLSRKDMYKISAKLATALNLPHLPFGGMNMIFAGDFAQLPPAMGGENVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Z6</accession>
    <name>A0A8H5G5Z6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Z6"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="361" mass="39247" checksum="33659C101EABF8DE" modified="2022-01-19" version="1">MSDTRTCSRPIQSCFQCRKRKIKCNRAYPCAPCLLRGEGDAAPDVKASSSSKSTVETLDDVVHRVSVLEKTVKQLSAFLPSNVSPSDLDELNALKSLPTSEYRASEKSNSLAKSITMNGKDHGKLLCTIRSAYGTASSDEDVAMMLEDFAMGHRVNRSRATQDLDCEPVSQACLYPTPASQDGPALFGNYDHPILSFPHASSPTDGMSPVFGLTDGHPLSLLIDPAVNLTAKLVSLLPSEGHCRLLVQFYFDRLEWYSKVLHAPSFFSEADQLLNQIAMATPSASNPDPIPSALAHISLPFLSVYFMLNIGFTEATELGAKMYSAAQATSYVGDFFANHSLGALQSFILMGVYRQNVDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAB0</accession>
    <name>A0A8H5GAB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAB0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034339208" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="616"/>
            <end position="617"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5361294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="638" mass="69792" checksum="9E70476E1454F63C" modified="2022-01-19" version="1">MKSSSLPMFHAWFLTTILVSGLAQSTSLYTDPRDVPMKEYDFIVVGAGTAGNVIATRLSEDPTKSVLVIETGIDDTDVLPVHVPFFGFNNEGSIVDWNFTTVPQKELNNRTISVPRGFVLGGSSSINLMIWTRGSRDLWDHYAKVTGDSSWSWDALEKYWDNASTYLDSTISTLVPPTSNPAIPPTPRSDPTLSNGNGPVLVTRPNFPTELDDKVINASMLLQQKNPHSRFKDTVDMNTGGSIGFGYNKETTGHGERSSSATAYLHPALNSQRRNLNVLIQTRAMRLLQSTNTPSNSTTSNDHSSVPHFNQVEVAQSIDGLWVSAGLRFKFSARSEIILCSGAIGTPQLLLLSGVGPKDELKELGIDVVADRPAVGKNLCDHPMLLTMYNVNSNQTFDDLTRNPALQEPLLEQWQSNRTGLFPNTPSSVLGFMRLPDDQLKGVQDSASGPHAPHLEMLFADGFLPLTEPLPANGHFITVLNAIVAPKSVGSLILASAHGGMFTHPFIDYNIYADPFDIQAMLQAINDTETFLSTAPWTRDNFIISVAGRNSTSIGTKEEKLAFMKDNTITVFHPIGTARMGSKEEDVTDSRLLVQGLKGVRVVDASVFPTLPECHPQAVVYTLAERAADIIKENHRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD60</accession>
    <name>A0A8H5GD60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD60"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034723352" description="Copper transport protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5362636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="164" mass="18014" checksum="E6627EFBC612A62C" modified="2022-01-19" version="1">MMALTLSSVLPLFLFFGPTLAADNGMDMSMDGGMELASGMMKTYFHFTPGDILFFQGWVPSSNGAMVGACIGLFLLAIIERWVNACRGCMEVFWGRRAQIIYANQLNRSKPNGQANGATPESLSNILFMRTRFAPPFIPSHDITRGLFQIAQSGLGYLLMLAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDR8</accession>
    <name>A0A8H5GDR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDR8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="480" mass="55056" checksum="B51F3E0542736723" modified="2022-01-19" version="1">MKTSLLTPPIAYELLRHPPLQNLDISTPSDEVDQAFSCLKYLAGSGRTTDVADYDRNWLNIWAWTSALIKSISAKEPPQTARGLQLRDDLITLMPCLFGYPEFTFHRKLYPHIVWSRVRRRADIFPTLIRLWMFAFDFCENHIVLWPLLLSNMRSNVAHLDDSDRYRHCRLFARTPGVLYRVFSYIITTVRCTSHYPPGGLPGEPPHIALELVHVLVAAGCRDVLELVLSHGLLDLFGLFKTRILRPRKIKTSTMTSGERLSLEVTECEERLELLYFILSMVDAAMLDDTYKGPACAHVLRMGLPMFIIRATSVVLTAKVSPERHLYPQERLFGLFSAILGHLQTTFWNKCILKSFWRSMRKVQVDHAKALEAFLDLRISLRVSTHCRRLIDVWMETFRVGEKMTTRWISLESLGVVICANPESNHSSVRVKEYTLTKGFTEDNVHDAKQCIVLNSVKSKTGRYIIIGRNVINSTTVAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDX7</accession>
    <name>A0A8H5GDX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDX7"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24188" checksum="6A20CC0752291CF7" modified="2022-01-19" version="1">MLAITRNRQIPSITLKTELIGKVTGRKIDANALIDSGAEGIIINGQFAQKHQLTLLPIKKPFPVRNIDGSENTMGWVREYTIQDLRIYSQDNKVYHKEKAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRIGMTRCPETCIIANPPILHLKTKTKPLKSSRRSKNPPQRLPSQMVGTNWTIQTSCPIKDCRATLLDSYSILPSKFGGNGDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE91</accession>
    <name>A0A8H5GE91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE91"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36511" checksum="B2C0077BA9298204" modified="2022-01-19" version="1">MPPYAAPSTTFNPTKDFPSKLKGKVVLVTGSSSGIGFASLQHFSRMGAKVYMAVPDEERTSEALECVEKEGREPGCGEVIWHELDLKDPRTAKSSALRFMEKEEKLDVLINNAALISDNGKPQLNADGVQDNMAINYLGPLVFTQTLLPLLEKTAINGDDVRIVNVGSAGHKDVTYLDYSSKDAWNYKFRFTLLPTLSRYTYSKLAVHLWTNHLKKRLAANDSKVMVLVVHPGAILSDGAIRNLQTLPFPSFWIWLLGKFMYPQEQGAFTTVFAACAPRDDPHIAAPGTYICPPNVADPQGKAALDESKQVELFEFTRNLLDEIGVEVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH07</accession>
    <name>A0A8H5GH07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH07"/>
    <dbReference type="OrthoDB" id="2587968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="30095" checksum="59A1E4946AC076BD" modified="2022-01-19" version="1">MSVSLWSRVGPQNTTAIREGLRMARKVFANEHLSATGLTTSELYQLMLKEKPVEEFRPYDVKKNVLGAHWKLSAPGSKKTVPPLPPHPEHPIRSMSFLKQQVLPIMEGNKEIRLATATRIPTIVVEDVREGQSKNKGKSKPAASVAAAEAPSPVLVRLWKPITQPIPKMQDPNFGKDLKPEGHEVGVGEDWGHLNKRRKRKRLVMVKKEYRFLATTRKQQAMEAFRKEREEYDALKDRQWQKRMEKDKLRWQRRQSRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH39</accession>
    <name>A0A8H5GH39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH39"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="341" mass="37214" checksum="3B9CE3A7894B4F18" modified="2022-01-19" version="1">MDQSKNKENQQPDTGAPDPVTPAPKRRPGRPPGSKNKPKDPNQPKPTPKKINADSPQTAKKTPCPRAVYSVADDKKLMEIFIEQKQEGNGMDNGGWKGKAITAAVAGLAGSEIESGGAPKTDQSIHDHWDYLKTEFHIFKSLVEKSGWGWDDENQCVEASDEQWETLALVDECLASYRGKSFPIYADMLQLLEGALATGIHAYQAGKESNTVSDSSSDGESEKDATPGSKRKVSALVETPDPKKHGRRDRSGRSSTSSSLMHMSHAMDNVALAMKDDSDDLGKKVKKQACELVRGVEGLSLGDKAKLLLLISKDSDFAELLVNTEDDVELRTEILKLKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI81</accession>
    <name>A0A8H5GI81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI81"/>
    <dbReference type="OrthoDB" id="3174721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="282" mass="31964" checksum="8361FDD9AFB10E73" modified="2022-01-19" version="1">MSSRPPSYATLPDGSQERAQDLVTSALEQTHRDRPEPSIDTPPAPPLLQARLADSNQHQVPFGVPPARAERPETNVRYTLSPMENDPSSLLLLPSAESPNTRPKFQIKTVVNPLNPNSFVTTIHQGATANGRFIGAFEMSSNRDPLYEWVSYGNLQQQAFFYVLDIAGFGAFTARNPVRPRNWKYRDYEFYWCWENGGFTRCYATDPQSVSTNPDVQPKLYAKYSPRRLRIDRSLGTAYYSVALEELEVTPEGHEVLDQILLSLMIIERRRLLGYDPKANVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIF3</accession>
    <name>A0A8H5GIF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIF3"/>
    <dbReference type="OrthoDB" id="3353107at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="250"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="322" mass="36413" checksum="46EAE65B039FC073" modified="2022-01-19" version="1">MASTTPILPPLPPYPISELYPEKSWSSSVYSAYQELRSLFDHASSVPNEEADPIRISFHAEQLAGKGLIILLTFEEFAQQEHLPMDWIKNTTIAVVGLLNLLTGALKSLDDSNVHSLHTLTLLRTGKPGRPRKEIDSTLLQAAAAPDRMCRSRMARSLGISAKTLRRRLNDRGLDVTYSDISDEKLDQLVRAYRHSHPTSGHSYIISHLHTSHGVRVKRQRVIDSIHRTDGVGRVLRTKKRELISRRTYHVKRPHALWHIDGHHKLILWGIVIHGIVDGYSRKVTGIRASGNNRASTVLELFIDAVQMNVLPSRIRADRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ34</accession>
    <name>A0A8H5GJ34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Etoposide-induced protein 2.4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ34"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41359" checksum="EF4BC38DEBF82EEA" modified="2022-01-19" version="1">MSAQPTQSSFQYPPSGRSSYPSFLSFQESILLQLTWAWHGFVDAFRWDVVASTVASDAEIRANFAKSMILNGVALTSIYTFDWLLLPLISDRGDRDQQNWLHRNVGWFYQVLWLFPVIGLSFYLNSSWCTLIAKRTYALQYGNRGSAPQQPATYTGMLKSIATSAYRAVMVLTSVIVSFALGNVPYLGPVIGFLFFCWVDAYYCFEFVWIARGMSLARRIRHLEERWAYYLMFGLPSAALCTWGSTLANAALFALVFPMFIIMAMHARPLPIDPYSPIASSQSDVVRHPSPFVPIRLPIFALVLFLNDWIVKILTVGGGNSRSSRGRAFSDAAENAEEGSVLFDARRKSSETKPTRARINLGRRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJL7</accession>
    <name>A0A8H5GJL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJL7"/>
    <dbReference type="OrthoDB" id="3270987at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="716" mass="79553" checksum="E93F411FC5C29E5A" modified="2022-01-19" version="1">MRIPSPCFSPPNEDNVEAKSQHLSRSLAPASAPFQDTPVFTPPLSHKVFSGTTVLANDSRRRSSTASSPSLRPVVVSETKPLSPLSISNLPVEMLLEIFKWACPAESPLSTENTTGPRAPPVIILSQVCKHWRAVIHEACILWQHLLVAPRAGRTALRCPVAEWLSRVGNHLPIDVHITDVNLGRDFTPPTSYPEFQCACPRLAALNQWLVHVPGPTACLGKNLILDELLPHLLIFSSSFRSLRTHLPAWSYIPKSGSLGLLQHAPLELPKLQSLDLTFSYMGWDYSEIKLNRHKRLYDEAFVDNVSNTFSVAPELKFVRIAFDGVNDRRCEMYESDDYRGGNYRTGLEILDLPYHQLATLYLENVTTTEPSEMRRILAAGVNLETVSLTIGWQDGSEDLYTDFDHKTYDKYSFGIWNLVEQDDDVDGVGLSDNVPEGMRRIPPPVPPTLTNIPDPDATLGGTVSVAQLTKLKSLRVTLQGTGGAAMFLRGFSFPALEELIIVHAIRIPHEAIDIATGASDTNGDRISSVKARTRQQLIERVRASLYPYDVLGSSLLYSQHLSSSFSSLRSLRLENLQGVNATHLLQFVKGVGASLNTLYIQYCPNVDLGVFAEGMSELDDNGLGVLAPNLQTFHFEADLTHSGGNPNDIVNMLARRICPTSPRTACADDDHRTMSRVTSIAIRFFGRKDFTEDSRKHLWKFQAFHKVKVKAKCWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJM8</accession>
    <name>A0A8H5GJM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJM8"/>
    <dbReference type="OrthoDB" id="3062174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034780762" evidence="3">
        <location>
            <begin position="23"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="841" mass="91450" checksum="089F77160DAA92ED" modified="2022-01-19" version="1">MSLGLFPFIVLLLLLLNHRVGAEETSLGQGVHNDLIGNNVGEMMSMADCKRKHVETFFLRRTRSRVTFPFLSSSSASTAAVPDSNSKHYCYCSNDCTLTSGSRRTSFAGNWVNEWKRRSMASETNFRSLVFARQDDQDNPDTQGDDKPWSALQLITPVIVGIVVAAIMLTLFVLYRRGKFTFASVKDIPSKVGGFFVKGFGARKVRKAQRNQSWVIDREAMELDSSPPPSSSSSRRPGSGGHVRLTSSTSPSDVSNHLDFPFAKPSKSGKSIWVIPGKKLWQNSTLVQKTRRVMLRIPLPWKDSIKPVKPITRGRRFEIDGSNKSTRTNSTLTNFRKAGFRTSGVPSQTTESSGPSTGFAFTDIHEPIYEEDEFSDSSSDLGLGLGMRNAPVDFREDDETENLISPSFDAERDVMVISGSSRSYFSVESGTAGTWASSNQVIPSSYGPGSETYRSNQSPERTTAPPLSLTPAGRLPPAPKYPAPVPVPPPSVPSSSSPRSQLHRLQKPSIESIIQQPLVNLPPVTKPDPRQQPDYSSIPPPPPLPPPAAPPPAQTLILPPSSLPPSIPPPPPLLPSQPSLPSFEPPTPLYTRRNPSESSISLHGNGLYQPASQTLSVIPEVNSTRTTGLGLHHHQRSESSSTSISSNNSLNGLIPQISSPPYRPSPLPQEIMIARSGTPPPPITPNSLLLSPERTPPVPISALTPPVTSPRSRPLPLPGSVATNRNQNQLPQSQPQSQHRRIFSADDAPNHRQLQPDSFADRNANRLSFSDAYAYPTPLSHTLNLSSDNVNVGNAAMLFPGPVRAAGYLQGGNMSSESVSLRDGGKRGVERELRNEESFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJQ0</accession>
    <name>A0A8H5GJQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJQ0"/>
    <dbReference type="OrthoDB" id="2623028at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="47551" checksum="59E9AE72FA1CEAB6" modified="2022-01-19" version="1">MDQNTSIIAELRAEQVDQISDNVSRLSYRLASLDASADPYSSPSSPLPRRLQWALERSKELFNKLEPKQLVVILPTIRKLMELLLGRLVVLKERKNKLPVVRFLPCNSDLPSSELNGPVPSEWLAMFVHSDVPSVCIEDHNTCCNVCLEDFEEPALAAEFQVDGGDNETQEDCLPMFQIDGYDATFECPTCRAEIWTSLSISSDQQQTSDDHHNNPPPWHKIDENMLNWAAWFIRDFDEALNSTTRGHPVNINTLAIWSDQTYKRYIYSRMTDSPEGLVDCLIVGPKRAQSIGALVSKGEHGDASRELERFWGFSGLQGAPCLLAVLDKHDRQAECHWVVHRFSLPDGALTTYRFHTELQACPDCRPALWWPAICLAWPDATICPNPGMPTLIHIDQPMELGVDDCCCSWYMGQHPHGFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJR0</accession>
    <name>A0A8H5GJR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJR0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="16905" checksum="00F9290725D8750E" modified="2022-01-19" version="1">MASQKARTDCISQSDNAEYKEAFALFDKKGTGSIPREMLGELLRALGQNPTQAEVTELVGSAPREIDYKTFLTILNRPDGFKPAGTPEEFIRGFQVFDKEGNGFIGAGELRYVLTQLGEKMTDEEVDELMKGVQIGADGNVNYESFVRTILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLA1</accession>
    <name>A0A8H5GLA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase</fullName>
            <shortName evidence="5">UDG</shortName>
            <ecNumber evidence="5">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNG1</name>
        <name evidence="9" type="ORF">D9758_003995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLA1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="8">
        <location>
            <begin position="171"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5367126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="399" mass="43309" checksum="832422126AF82AA8" modified="2022-01-19" version="1">MTSHSEDSAVYLEDLDTPKSSQKSETSVTAPVSNGAPLAKKDASKNPSLKRQATLDAMFSQKTSSEPSAKKLRLDASTSSLSTLNGLQKLNSIPFSLKAFRDSLNEEQSTLLQLECQTLGKSWFKVLKDEIKKPYFIALKRFLWKEGLRSINDSVKPLTVYPSPADIYRWSNTPLGRVKVVIIGQDPYPGRGQAQGLCFSVPLGVAVPGSLLNIYAEIKAEYPDFVPPRHGCVHTLSHVSVIPAYSSGRWTLSIQISNLSAWASNGVLMLNTCLSVQPGNPGSHSGKGWEQFTDKVVDVVNKYGGANLPSGGGVGRGVVFMAWGAFAQERVAKLDKTKHLILTSAHPSPRAAHRGFLGNGHFRAANEWLEKKYGAEGKVDWCRLDVPSATSDGSPKPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM35</accession>
    <name>A0A8H5GM35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM35"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="486" mass="54239" checksum="B28CF1F9D476C147" modified="2022-01-19" version="1">MSLLKIADDRWIRSPPSVKSVLCFSANAFKTGSSSNHSPSCGLGWRFYVQTASKIPSWGNMQLPAMLYFDPYLLRHSAFKRLTIIVSTGFASLASSHYVETLGEVVELWNFLSFDTRLEITVEFPSDLGLDFPSQPSLKMFDLVADAADGRDVFDVVFFLYHTQSLRNLNKRVWIQLRPIYASTALLRDQSSYLDTLLGNDFKEASFVDVSDIPSSMEEYDYDSDSDFETDLDNALDRPASAQDEAENNHPETSAAKHKVDSSAESALPAASESDDIKPRGEVQNNAKTTSARRLPHPIPLKNFAFKTWKAFILYLETQRITFRPLTSQSPALPGTVTEPASCSPKSMYRLADITGMEDLKRLAFSAIRSSISEDNIIEELCSSFASRYPEVQSFEIKFLLDCPQSKIRELCQRLSDGAFVEHQPIIAEVLMALVTGRMSPRTPRPASVPSVPSVPSVPGTPTPLREPPSLEPSRMVPIQGWTRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMI3</accession>
    <name>A0A8H5GMI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMI3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="79002" checksum="72043AC19EA9BFDE" modified="2022-01-19" version="1">MVRAQNPLLRTLRVFGLPSAHSPIISGFLDEFRIMGPIQSIVPNRKSRSLDITMYHALCLEVFLEKAKYPHAYESLKFMTGEPSKLPVELLARLIYRNATRALELKPLEPHMDKKWLMQLLPKFGTVEKLEIDEKNKSAVVHYMSVSEADLASRSITKARMINPIVRVRRVDDRCDEFLFRDEPMTVAITWPVGSLNVGAIFRRGFLHKTLNHDLSHNLPPSYWESNVEEHFIRQDKNTVTGYFVFKSHPAYQDFMTNFEVNPMHASLIKRSPAPNFSKHKNKVEGTLFGATKTLRLANLDPYLKGEDLVKDFHKFSTTPFFVRTEDRSCAHFYFPSPMLPSMVIDAIWKGKIDRVRYKGLEVTYGSDHSHNPSPVLTTPKHAYLEPLVTHHEPHMDKKWLMQLLPKFGNVEKLEVDEKNKSAVVHYMSVSKADIVSSSVTFQKLTILTHSGLSFAYASHSITKARMINPAVGIRRVNDRCDEFLFRDEPMTVAITWPATEVDVGFIFRRAFFSKGGKTPNGEWSPDALPALWEGNVDEHFIQKDKNGISTGYFIFKSRPAYQDFMTGSEVNPMYASLVKRSPAPNFPRHRNKVEGTLFGATKILRLANLDPYLKGEEVINDFHKYLHKPYFVRSEDRLCAQFYFSSPMGKIDRVRYKGLEVTYGSDHSHDPSPAVTSPKQIYLEPLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMU3</accession>
    <name>A0A8H5GMU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMU3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="72" mass="8321" checksum="305A48211935DB4C" modified="2022-01-19" version="1">MLSKYTLIARGQAEPGLWRLSQFQRMSKFNKSTRPLLTDSEDSDIPVLRQISGIVTASLRYRYNTRVFALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNP6</accession>
    <name>A0A8H5GNP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="219"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1421"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="808"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1599"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1800"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="705"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1608"/>
            <end position="1620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1856" mass="202275" checksum="D0E8BC1551980E14" modified="2022-01-19" version="1">MSSLAFLVTELQSLASETRRKHPEIREAAEKSLAILRTSPEQATANLASDGPQSEDLLKPVFMGCATKNAKVVAISLGSLQRLIALKAVPQSAFSRIISTMSDAMSQGVDIQLKILQTLLSLVTNFPEVHGSLLGDPATVLALNREWFGRSQALLLCFKLQESRIAVVSSTAAATLRQLVMFVVDKMVEEDKKDVEAPEGTLEEVNLPNGTTKALGPSAKDAFAVFEDLCLLANSEKPNFLKLDYLHKTFALELIESVLTNYYIPFRKHTELTLLLQHHLCPLLLKALSERPVFPLVLRCTRVVFLLLKQFSGELQTEAEVFLMLLIKIISDDSEGNQDSHYTSRPQWMRVLAMEIMRGLCSDAELMRNVWDCYDGQDSGSKVFSTLITALNRLITEKPALLGVGSQMFGVGVPNEAVSSSGSAGSSYGDVGGMAGMVANAASATVSGVVGMMGSSAGLSLQNSAMKLQCIDQLDKADAPPIPESYIYLLAVQCLISLCEGFAAFSAPLYSSIVVQKPRAAGEAVVRAPPALDFDSLPPDEPSTKQLRIVRDIIESGWPALLAALSFVIATNLSDELFVDVLASYQAMTNVSGMLGLTTPRDAFFTSLSKFAVPSRVVLSVDSYHEPQTPRSASTLTENLGLVGPAQPPGLSERNMACLKVLISSAMFLAGSLGESWFGILEAMQNADYVLTARNTQQGTPSKQRMSLSGSGRSVSGSGGVTSSMSQGTAVSSVPPPSSSGSHTHPLLSDLDTETMLNAMQRLFDASKNLEDGAFKYFVDALCRLSGEMVGMQTESKMLDVIAEGDDDETLAGSTSGGPRTSISGTLSPHGSTLSVDKLHRRRLSGIHIPRARTGDFGINRLGGVALLNIHRLIYRPPEVAWDTTTTHLLSIIRLAIAPHSIRLQAARVLDDILIIVPRNLSNTGELQAQVQKRVLEVLAQQVMPEAYAPASSTSTSIELRRMGLETLHQILQASGHTLVIGWEIIFSMLESVCRPPTLGRASSFESIPSSPAASPTKPRPASLGLGLGHPSDKNYTTLIKIAFQSLTLVCDSVQLLSPEHLRLCISTLGQFGRQVETNIALTAAASLLWSVSDAIQAKRKDVEQEPEYSALWMFLLLEVLGLCTDERPEVRDGAIQTLFRTMQLYGATLSLETWDECIWKVTFPLIESLTSEIRRRAGMAVGMDSAEEHAWDESKTLAFHSIGSIFHDFLSSKIIHLESFFKAWEAFVMHIQESVLLDNRNISSPALRCLEKAVKASSASVPEHNTKVGEIWQKVWEMIDHVGEAILKKNTNQVSATGETALPKPFTQDSLVAFVDVIQCTRNVSRAIEGVEWPLDRLTRLVAILKGVLTYPYSPDYRPDIDVLPPVQMVVMSTVAGIDLSAPGTPSLVMRDLSEYATLPFLAAFDVPPNPKSQTPQKRITYIALAKKTMPTLVDLCLEFKNRLEIYTDGTLEAVLSAYSIPVKLKYDCPAPSKFGKDQPLWKTATTSFLRIVKECAPQIKAFSDEISDDRLEGIWRQVIDIFRGGILADCAAAESFPLHVQEEEENFDLALIAALEIDVVPHLGDRRLPDSIVTQLAKVLAQGSRLYDSDYGVFDHSRSRTPDLPQVSTGKTSPTAQKSVKVDIETHQGHGSTDPGALLPRERFSYWCFDLLFLVCSDLTKDQEDSRRRLAALSLPALVNRCKTTLVGYVADEALRGNLPFPRAREDELLYVLRKLLELRLWSGSLWAALSTDPTAYCVEQPAAEASTPSLLIADAVKRSSVAHLFHFYSVLCEIVSIPRKTPSTWIPANSVSSIGSVSSNVNGRSHDQPAESDNVSSGGVNGDYGHDHHMTHLDARVLARNCLKVIGKEMGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNZ7</accession>
    <name>A0A8H5GNZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNZ7"/>
    <dbReference type="OrthoDB" id="2555515at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="379" mass="41117" checksum="494DAEF1973E2C58" modified="2022-01-19" version="1">METIGQSSISALTQHPVQPRNPSKKPHNCRLVVVANRDAFSNARGGIRHSAAFGFKVSPDVDLEMEYELPLWLLMDDEFQKRAAKYYPNHDVLDPHFMVAPQFIDNLRRASTERAAEGGTTADVVGDTPVAQDALSNTKDLSPITPEMSPNTEHALPDPSDVPPSSNDPAPASSAPTKDVSPGHGDHHMEEDSVDSPAVVFGTGRGRGSRPRLAVQPPKKRAKIVPEGQSDIPTDMTSAGVARETSVPPIETIGESISALVQRRPSKPTQPRNHSKKTQSPMSAVVTRRGDPVVSRGGIRHNTAFGFKVPPDVDLELIYELPLWLLMDEAFQKRAAKYHPGHGVLDPDFKLDQQLIDGMRRASTEPAVDGVAKTDVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQC3</accession>
    <name>A0A8H5GQC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQC3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="251" mass="27994" checksum="D0CCDF66A1DE6A3F" modified="2022-01-19" version="1">MTSQQNSSSKKSGNHHHTRNPMACTNCRARKIKCESNRQFPDRPCQRCTTRKLRCEYVAISHPPPTNDQNSHHRTSSTSSASLTGKHPHTHAPSAPPVPSTRYSPLSYTSTPRSPRPDMDCGFRTQSPYPTSIVSPRFSYPSRETSSPAFDAYYSAGSNHDPTAIGMSAMSHVSNMDIGFNSSSTIPRNAPHSFPDGMEYSGYLDQSSLDWGNNVPLQNNLSQEHYFPSDCHCMELQCTCGRRRSSSYWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQL6</accession>
    <name>A0A8H5GQL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQL6"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="27510" checksum="A6434554F1989C6F" modified="2022-01-19" version="1">MIHNLVFHPPFHLLEFAPYHLWLHTVLVMFLTSAPLYLIRFVLFPSSFTPPLTFYLDVLFDDTKAVDAAWTKLAHNLGKDPAKVTSASHGKSVTDAMTQLRPFITRRRLEFEVAKFEESILDFADTPSHLKSMNSTPIIILPGDHPLLLAQMILPHPHQHRIIRHPIPAGPRYHRFPRHLYVMVHLPPLLLLGALVTMVDFRQYARHVGILTDTKLHPYSNWPYPASARLAERYRWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSU1</accession>
    <name>A0A8H5GSU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSU1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="114"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="685" mass="74266" checksum="1BD0BB34C7F0265A" modified="2022-01-19" version="1">MPTVLVANRGEIAIRVLRAAKELEWSTVAVFTEKDTSHTAFADEAVKLDNVSQYMDAKSMVEVARRTHSTHIHPGYGFLSESTELALACQEAGITFIGPTVDTLRVASDKMKSRQLAISLGVKVAPGDRIRSPEDVIQLGESVGYPIMIKALDGGGGRGIRIVEGSGEVEDAFKRCLGESPSKQLFAEKALTGPGWKHIEVQIIGDGKDVVHLWERECSVQRRFQKIMEIAPSSLSRESISPLIDSALRMARSLRYKSLGTFEFLFNTRTSDLIFLEINPRLQVEHTVTGEILHTPNGYYSRKLTTPFLEEIMSIDILRAQLLLSLPETSLHSLSLSTVAIHRGCAIQLRLTAEDSSRSFTLSPGRILAKDLSWPSGPGIRVDTWLTHSAEWIVGTDFDSVLGKLIIHGLTFDEATQKAKRALRELRVGAVVKTNVDVLLGVLNHDDWRAGRIDTLWLERNLNDVLRLGSPGQKDSSPSQSLSPADMESAATSGGLGSQSTVSLRPGTVFNLTFSPQTSASSATHSLPAETKHTLTLSSVALNTFPDRLSGTIQGTILPVPFSFDLIQSTSVSLSSSEYEFGDQNNPSHVVSPITGKIVDLHPAFADVQSKTTGKAGGDDGQKIGLGRVKKGETLAVLSVMKMESIITTPRDGVIERFGNGVRIGVIIGEGMLVAVVSGELKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVM6</accession>
    <name>A0A8H5GVM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVM6"/>
    <dbReference type="OrthoDB" id="3360643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034477682" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="21970" checksum="B9C6CAE97FD5F167" modified="2022-01-19" version="1">MFSLRFFTLLFCSALFTIVSGQNWYTVEWDAPSFTALSGDMVVPKLPQPGGTPYVWPGVQSGDGVLQAVLDGRSGTWWIGDGFFGTPSLPWGNGFNVNPGDTVHFSFTLSGSSTWTCTLSSNGKSASTTLNITGSTMNRAIFAAELYDVPFNFGPIVYRNVQITATTPASQWCGSTAHLGSYPFTVSGNTASGNTCRIASITQNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXI5</accession>
    <name>A0A8H5GXI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXI5"/>
    <dbReference type="OrthoDB" id="10692078at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="997" mass="107917" checksum="2DD97F598D1DCED2" modified="2022-01-19" version="1">MPSISHQQQNLDSAKSVSGSPTQSTTTLNHPANANDAYNRPVYAHSSLLGHVQSQLGGGNHQRGASESRVHTSQPYGWASTMTATSMAGRTIPIPAATLAQCGSHITSKMTASMNTNTSSACLIQIQNTPISKRAGSTTIRFSGRHLQPDIFNYDSQTASAVSGGRPYQLSFPTSSDSGMANTNASYHSSQLYSYNSSVTPLPAPQTPTNPSPGNLSYPHTQNSRIQRPQGSSPGYQCEYNPDYSCAVTSSSALQQDQQWRHNGYIDPASAGVFPSSNWRASSNSSSLANALGPATVSVPLPASVNTNVVASAYKSGASKKSGSSPSTPAIHSLPSIAQSFRTSNSPSASAFQAGYTPTSSSPLGQYTLCPFAISLANAIRTMIISFKTSFPRSQIPSPHSPVPTLFKSDAERISVISYFNYLVQQWGSIADFNTFADVPGTQLRVLKLSPHHHALRPYLCKPRLEFGLIPVPLPLKTANLNSKRAPDLEGWVVLLVPQEFGRYRRLEHEDELLEILGRVMANAEKRHAEEEHYRSQRQSQRHSQPRSTSNSSKSHRYTHSDPHPHQNPNSNLPRHVNGDPYPPLHPYSRERQEERRPWGVEVESLHYNYPQGQLQPQHQHHYPQQHQRQNPHAPHLPPISTLPFPGAQGDQNHPGQHCSPSSASSSSSRSGSFSLRSVSSWGSSPPSSTSTSFTSASASSPTYPVYPKPPTHVTVDVVVKEEDDSEMSLLYPESPIIKGEQEEVQPLPPSQQGQGHARPRTSSPGVVDAVAQPEPQPIPMAAPVPSRPLSLPSLNSLSEHQLQLPSRPFMLSPFSPITPCGPSAPETQDQEQAPAHASTFTPEARGKKRPLQDIGNFDDDEEAGDVDGQNAVRSEGRESTSAPSSSKRSRLAISALTEPESESMMTTTARAGRVSPERPIRQTKMNLAGRKHLAVDLLCALRKRSASVSVSHSGDGDEGSDEEDDVPLYIRAKKSRMLGNSKAKAAGRSRARSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXZ2</accession>
    <name>A0A8H5GXZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXZ2"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="39017" checksum="CF4CCFFF6F37B347" modified="2022-01-19" version="1">MRPAASAFPMFLVSVLVSFLSFILHGFAFLCRKLKLTLLAQRFFLRVLSAGPIPQHVAFIMDGNRRFARRRRWQVKDGHGEGYLALRRLLEICLRLRIRCVSVYAFAIDNFKRSPEEVDALMQLAESKLLELCEHGELLDKYGVRLNVIGRTELFPENLQAAVRKAEDITRNNSRSILNLCMPYASRDEITTAVEDSVREALVLHSTKLSTTSRENLGNEMDTLSHMDITEETITSHLMSMKRGSPPLDVLVRTSGATRLSDYMLWQGCEDTQIHFSNVYWPDFGLLDFVPIILQWQRSVWFGTRQKPVTNHRSPEVRTLRGRSAERKGIGTRLEVNKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZG1</accession>
    <name>A0A8H5GZG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZG1"/>
    <dbReference type="OrthoDB" id="3215163at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="60986" checksum="C51C7DF727132997" modified="2022-01-19" version="1">MPLDHEPPRKKRKVSDSTAGFSGPDGFSKPRSSTTPKITAPVFESAFDTPQTRKRLPLTNTKPTSNETFRPAITGDVGPQSEKRRPLVSGIPKFIVGSSRDTPNSVSSKPTSSSRSNKSSSTSLDILKPFLQGAPSPFDTPSKPPSKSNAVPIPLPQPQPHVSKPTSNLRKLVAPSIPVPETPASKLHLRTLAPPVIPSPVTPVSSSSKPTSKLKPLHPPVISSVVPETPSKPLKGLPSQLSLLQPNLNPNQLLKTIGTTRVARATDLSLSSAEGGTAELASIFLHDAHSEIVKEPQDEPESQRGLNVSPQKGSGVGTVAAYGGHGGGKGPKFIKDGLAAKASMILSYANTSLALWTNEFSVSSNYVKPDLRIRVVKVIHTPKPANSLTIKSLPGLAICCLSPSPTNSSSSASSAQTRSQESFPYKPAAKFHSEQDDQPPRPVLAKFPLDLNERLSQFGESQSQPNSSDNSQLNTLLFLTLFSFSPRPTPASTPVRNPTDLEDGTEFYVWKPWGTHGSLSEEHLRSFAEVFSGSGAEGLRDVTTGRVFSPENLESSVLFVDRFAAARRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZJ3</accession>
    <name>A0A8H5GZJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZJ3"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034856439" description="Cupredoxin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13118" checksum="9966C12D2DAE1F66" modified="2022-01-19" version="1">MRFSLAVASALVAGVYAADHVVTVGESGLAFNPTSVTAAQGDNVVFQFRNKNHSVTQSTFASPCVASGIDSGFQMTPPNSTTFATWSFTVDNASTPLWFFCRQTVPANHCNAGMASHKTHMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZT9</accession>
    <name>A0A8H5GZT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZT9"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5374254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="436" mass="45219" checksum="5E325DEE8ED3232B" modified="2022-01-19" version="1">MKLERNGILCVISTSSKRSHGPIQFASSRLTKVITVPMTRSSYLPTNHLDLFRAAYISEPASARGTSTKTNEEGTRTLYVDQGFYVQKSQIDSDATFQHHLRKYINRCYSSKPFPTFSTLKLSPRTRTRNNMAAIFLPLLGLATLAAAQCPQVHVIGARETTAPAGYGTCQSVVQNIVSAFPGATSEALNYPACGGQAQCGGVSYASSVIAGIQAATSAINNFNNQCPNSIIVLCGYSQGGQVFDDVYCGGGDTNEGYGTTAIPISANAQKKIAAAILMGDPRHIPGLSYNVGTCQANGFAPRPAGFQCPYASNIQSYCDSSDPYCCNGNNANTHQGYANEYGSQALTFVKNKVNALLSGTGSTGGGGGSGTTSAPSGGSTPPSGGGGAGSAQHWGQCGGIGWTGPSSCVSGFTLLVGVSQGRKDGKEVERVGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1A2</accession>
    <name>A0A8H5H1A2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1A2"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="393" mass="43763" checksum="665806273E02780C" modified="2022-01-19" version="1">MESASGSDQTLQQAEPFDFGVRLGLVLIGEAACVSALTVGLLLLYILYSSVTLKGFHVNTTCSWRVSTQIHYYFINLLVSDLIQAVGGIIDIKWALEATVQEGVLCTAQGILKQMGDVGVALTSLAITIHTFSVLVLRLYSKPRTVLLVIAAIWLFMVLIVTIGLAAHRRQDYYGATQYCKFFHCCVLFSIMIELSLGCWITSDFDGERIALDLKLQRDKVKQYQKKLQAILDREEVIAKTHLAAGQKDKALIALRRRKYQQSLLIKTDGQLENLEQLVSTIEFSLVEVSVLHGLKQGNDVLKEIHKEMNPESVERLLEETAEARAYQEEINEMLANNLSLDEEDAVQTELRELEAALVITLPEAPSTAPAAQDAMEAEPSQERVKQRIALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGH6</accession>
    <name>A0A8H5LGH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGH6"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5356454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="286" mass="31091" checksum="0B18282C089AE3F4" modified="2022-01-19" version="1">MNVKDLSSKWLKVSEVSPHVVHVEITRGPVNAFNEELWRAYGELFEKLAEDAQDVRAVVISSAFPKIFTAGLDLGDAGNLTKDVNSDKTDPARIAIDLKKFIKVFQEAIHTPERCDFPVIAAIHGMALGIAVDLSSACDIRYAASNTRFSIKEVDIGIAADIGTLAYLPKITGNMSLVRELAYTADWFSAAEAERLGLVSRVVEGGRDEVVAAALELAKKIADKSPVAITGTKRLITHARDHSVPENLDYTALWNSATLQTKDMAESIAANRGKRIGKFGALRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ67</accession>
    <name>A0A8H5LQ67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ67"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="30420" checksum="58DE659DBAC69A7C" modified="2022-01-19" version="1">MSKDFKKRVLVLHGYAQNGNLFSKRIAGLRKQAKDIDMVILDAPHILKAEDLFEDSEVNEDPGSALRGWWKFSDAAKTICVGMEETLLTLRDLLMEQRFDGVFGFSQGAGLACLLSAILERPESYPGFLIDNKPVHPPFEYCISAAGFKSRDLISDRILSEGFSTPTLHIVGRTDNIISPEYTKSILDVSRNKRVEEHDGGHYIPSKAPWRKFLVEYMRRGPEGDVASPSSATSETPTPTPSGAATPLGDGSATAAEAEEKEMAETAVSSAAAPAGSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQY1</accession>
    <name>A0A8H5LQY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQY1"/>
    <dbReference type="OrthoDB" id="3264508at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="474" mass="54181" checksum="2C2096252A17D375" modified="2022-01-19" version="1">MAAEPVFPYEIIFHILSFLDYPEHGHDPLYRCSLVNWQLNRAASKLLYESVTFHRTKQLNLMTLDLKDDGLPDQRSPWTSALLPHNSPFVKHLQVSGVLNMRHPPKNRLPEALQTAIKTFINLSSVRFTPDQCYEDTFTEALKLLCECPSLRSVHLGGSWLDEKRAPILTELKGLQKVTIISPSRAVLDLFPRLLGQLSDELVELHLLDNCGSITPGVLRAFLPSLQGIRSFSLGLSYSITDDDLFDAVNQLPCLEDLELFYYYQQRSPITAPTLPRLRSFAVTLKEHPTSPQMLESLSKWIRKFVSSSSIEQLLIREERWFLDHKVLNFDSLVYHLTAKHSSTLRVLNMQHMFISVKAQKALFAKCKELEVLCYTSGKTSLSQFKNLAHGLPKLHSVALYTEHVGKLLGSNVTDEGATEILRSAPSLRTVIIDGWSWQGHWTTDDAGDVKLEAKQYHRSHSRYPVYWKRRMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSQ5</accession>
    <name>A0A8H5LSQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSQ5"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034486941" description="PLC-like phosphodiesterase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39307" checksum="4060D308AB92B2D0" modified="2022-01-19" version="1">MMLSMNRVVQVATTLLTFSAGANAAAANRRATTCNGHSELCDRSYGNVTFIGAHDSYAVGVNNLAVNQDYDVTQQLTDGVRMLQMQAHDNSGTIQLCHTSCGLFNGGTLEDYLKKVKTWMDANTNDVVSLLIVNIDNLPATQFDSIFKAAGLDSLSYSPSSASLTASGWPTLGEMIDKGTRLVTFIDNTADFSTVPYIIDEFTNIWETAYDVTTSFDCAVNRSKADTSTSMYLINHFLDKVLLGAPVPDVANANTTNAVSGSNSLGEQVDLCVTQMGKSPNFILVDFYEFGGGSVFQVAATANGVEYSPTSAIATPKTSDSGSGSSSGSGSGSSSGGGSNSSTNGAVSPVLNKQQWMTALTVVFGFAFGAVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTM0</accession>
    <name>A0A8H5LTM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTM0"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="37"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="928" mass="106398" checksum="B720582F20347715" modified="2022-01-19" version="1">MAQDDEARDLEKNDLPFSNVRERFKPTSDDDACFKLWNMYISQAQEYDRALIESWKSDMDGMLLFSALYSAVLAAFIIESYKNLQEDPASTTSDLLVQMSKQLALLSNGTVFTFEEPTSFHPTASSLACNFLWFLSLALALTCSLLATFVQQWTRDFLHKTTMRPSPVVQARVLAYSYFGLRRFGMHTFVDTIPILLHISLFFFFAGLVAFLLPVSFPLMCLMASVLAGFILIYFGLSYIPLFFLDAPYRTPLSDFLWRSGNRLHGYIIRLHGLRGDLSLTEAMIEKSLQESSDRDSQCMEYTMKQLNFDTELVPMFEAIPEAVLSPRGGVRLENFKLVASLIQSSEPENSIVSRISHFISISGTSSDPANQVRDMTYCLKALRSLALLVIQKPTQNDVDDTPMFWFDRSLLQVLAVSDTTLRDHITPAIALVRTSRLQSLRRCIDMVAQILSFPSTPAYEKLQLADNVFRCMSSDDIDWTSKTFLDHFINLGNVLMKRISDDWQDRLDELVTEAQAIVSELQSPTRWKAALISILGEFLSRAITDAVTPIEMDVTWKTILTSMPLSLFDQTLEVEEDEAAASFVLKTETILPSIVQPEMFILILRLFFSTNRGFSFHGSAKCRSIVQWYLHECQPYQRNYLVMEDTESRLEECILQDLRADESDYPTWCVTAIERLYAGLGFEFALVPPRLHLFAKQMFDLIPNVSSKFNRDRWWPVTKARTEWILCADIYNKLYLSESSDLYTSTLEDIRALGGRLMPDIAVPEPPTSPDSTELHKQWIVDIRKYAMSMVVFIISKFIVMSSEDTGGVLLGDWIGMLNKLYQYEGQIYESIQLQFAESIMMLVSVAPWNQPKENAASQVFRDWVWRLNQDWIWITDLSSARIIAEAIQRHKNDVNFRGTLWQEQVLLDQCSRIIRNAEEEHEPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTX1</accession>
    <name>A0A8H5LTX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NCA2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTX1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5369261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="82738" checksum="1060992533759863" modified="2022-01-19" version="1">MPSSFVEHYCAPLKHSSLNLRSALLINSENQDATIAKQRLQKVLTSLDKSRSQQIIREAVQLLQELNPEQEVADLTTLEGTKDIEQEALELTLLNQLVVGLYAESLDMFLQQSVQAEKEAQWWDNVARSNFRIWLYLLQTFPLRAWNVSYTISRGLQANNLSLSPSHLTPRSLSNLFPSRGLLHPSALITSAFPHLHHNPQFLPLIFFPSLPSHSEELVNFKSGLHFALESLKNTLNSICYTLILPYHYTRQECLSKKKELESIRDNRACTLGKLAQMRQTLQRGLEKQEKERGTSMKRFISTLQLGKEKEKQGRDESALMKKFISELDEVVSASGVDVDTDVVSSSPKPPSSSVIAALSTFSSSTLQFHLTRHNVLLRTHQLLRPSRYVRLWPQALFGPPLIYYALTSIYQSRKSLQEFALDTKQVVKGFLVDWLIEPLKGVIDTVRSKDDSGVGVIVSPEGVAADYQSLERMSLALAKEKLHYGSEQLEELSQRIKVGDLTPILKLYEEDIRSPLRNALRGTLVRTVLIQVQKAKVDIDQALAGIDRLLKSQELTFAFVGVAPAIVVVYSLGSYLRSLLGSGRGAGRYGGKQQRERIFFVMRRIERLLVSDRSRSRSRLSLLPIKPNTNPNQASAQGVNLNANNNNTGTNNKLELTSLTAGLLLLSISQLRTFAETYLPAGSRIREGFLEDVDDLQDPEFDANERLRVVERMWRSWGGVFGWGGRGRGYGVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV61</accession>
    <name>A0A8H5LV61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV61"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="41966" checksum="25430AB6FC9D0D52" modified="2022-01-19" version="1">MSGPDTTPHPSFALQGFYGWVEPLKGIYYGPGSTASALPKHVEVLGVKKALVVTGKTLHDKTDVVKKVEDILKSINAYGATFWEIGEHSPIAGIRNGIKAFRDAGCDFIVAVGGGSPIDASKAMLYYMKQEYGVEIMPQIAIPTTLSAAEYTVGAGYTDDEGVKVAVTDPKLVPAGIILDAELTLTTPERLWLSTGIRSLDHAVENLYRPLIPPPLKIMCYAAITDLFKYLPESKTNPQSLEVRQKLQLASWMSIWPHSRPTYSALGLSHTLGHKLGAAYSIPHGITSCLTLAPVVKLKAEVASQEDKECLAASLFYLGKPSTGTLEGDVRLLSTLITELVSNLGLHSNLTHYKVPREDIHKLAVSSVGSEEDPDVEKVKKLLEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV79</accession>
    <name>A0A8H5LV79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1658" mass="181660" checksum="0106A864002C8C0F" modified="2022-01-19" version="1">MEPDQPSASDQREQRLAAVAKLKRAASLPRLKDGRRPPMHTEAVSEGEKVATDEEQNPDVDTPPLLDEHIKAIEDPVETEADNEVEDAPANPPTTRSKRRSRSRSRSRGSKDFKGKGRALQSPTPSPLIPGDSSQDEAFTASPTINLPTVPPIMSPVPSHIQSSQLLRSVTPTMPDQPFFFQPGTSSTPLPSLEAIQKGLFRSNSAGRMMAMAKLTGGTEVYDPCLSPSPTPPVAAKFRRNNTVSGGERNAARKNLLDTLGGRSRLNRDTDGEQGSGNDEIHAPSPSPTPRRRRRRSRRGSSVTPNPPGTDSEFQSTTPNTPNVPPTPLPPYDQPRSATPNQIRSRGPTPNPIPNSRGPTPNLLLLSRGSTPSPVPPPRGPSPRYSPHDSPQPPPSFISERDRPEPTRRRSVVVEEEEEDITHPPLPNTPPTHFPVNGFISRIPHSPDAPSDMFTEYTNASGLHFTQPDEEFFPSSPFHSPLREKPVRDEDEVLYPADNRSYDNGFDNEREISWVADPVPVMRALPVDEDEEDDDNDAEDQYEEPPSSTRSSNGFPVPSAYDDMSPRSSDSQQVIIEYEASPETISYVPPSPSVAALSQSAGQRRSDGSMSYPQRLSVASRLQGERSPLSAEFGDLDDRAIINDNSSKRSADSMSTSAWEKVKSTFTRAGSSTGRRSRSNSIVNRERRDHTDSSVSRESGLSLTNQKSDPGPASTSTPQSQHRVLSPSPSALSLAQPNTRGGVSPVPPPSSTDLAKYQNAKLFPFPGMRILEEERERNRAKGLIAASASTPDVSAFLNGAEDGPIPLQHSNSSGSADWSKDRPLMQQSSDSNLVGKYLNAPALYPATSSSPLSPTGPEYFDVQPASSSASRLPMTLPGVKQWLSKNKEKLFSSQSSSPLISPTAPNGPTRNGQNGMKKPSLSDLLKRKENELVSDWEEAPTDSSTLNGRSQSSSDQLRTDSVPTTPPAMGAGSTRRFDLSDNERTPKASRVGSIPLKSVPSSDSGSQFPASDTINAIPSPPDVVSSTTPDPSSSLSDYPGHTTSDSSSSISSRYSLEHPGPQGSVVLQRLEENLVRGSRSPMWASAIEDPPRKVILSSPVLQVANVNTVKDRFLFLFSDIFVIAKPVTQDDPTPERKFIVKSVVMLQHLRLSADRSDAVPTPVTSSNRSPLIRSFVHQFGKDPDQAISIMFSKAGVNDDPVLLGQLLFRTVDLDRTRLGLYLSQRTSKLVLKSYVDSFGFVGLRIDRALRAFLLSVHVPLRSVNGHSALEYLLDAFSSRWYEANARFVAYDKDLAIRLVRGIMQLNDVLHDGMAQYPGVTAPPRHNISSRDFVDAFRRYDTRYSVSDELLEDIYRSVIQERIAHARDSLNPANPADIPITIKRPLPTRITYKVQSEPVIFRIPQPDPHLSIHLYGQDLVFDPPVLTFAKSSEAAFRVQGTSLGSKTIIIHRSGPNALSYSGLPLGQTITIERAFMRNTFQVAFMSHAGTKRRYMFSVDDSLIRHQWIVSLKRQIESSRTSSTSSSSSFATPDPNRFYRAAQIVAFKVLQEALIGPEISRASDSLVLNAYEKLNGSRTFPLRIGGSHVRSKSRSQVYHRSRAGKDEPDFGPGSDERSDNSQTNAKLWTGRELETQCLQNSSIPLVLSYLQIGSPELTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW21</accession>
    <name>A0A8H5LW21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="819"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1572" mass="165623" checksum="1446178A1C18ED1E" modified="2022-01-19" version="1">MSSNDSFPATSIGRTSRFLSSLSPNSSSATPRSRSPSRSPSHDSLIAHPLLSPTTATAMATTTASSTSNSTVWDNGYGTNSASGSGSNKGGLGYVPYTPRHRPNPTHSHTYPQTPHAYPHAAENPSVLVTPATSTSLADPNHSSQAATKLQLMNLKAAAQGLGLDARSVGWAMLEGLVVLGRSRNEEEEREWKDIWNALSVGKATLFLPISPLDTSTTQITPYFVKNHVAYISSDSSETARTVVTLSGLRGTMKDSSTLSITSTLHPHTKSFRDISNPNPVERTAGFASLTDSPSIDVTRHPSYTLPSQTPSFSLPPRGSLSDPSQPNFKKPPLPPRPGSTRGPSSASLGTPNGGSGSRPGTPSGGGGGGGGAGGRLSALAGLFGRGSSSSSASASAAVVATVPQPRETAKEQEMLSSSPNTGTILSSGRASTSRPPSILSTSDSASVLSVEQDPLGSASASTTTTSLATTVTGVTSSTSSTTGTGTGNDSSSPQIHVAAYTISEPLVTQKVLEGVWKSAVKEIEACLNSTTSGSAGGHGGDGGEYGHRHEHKTPEFLDDRVLEFLERERVLPVLRAKTRTKGKIRSRKEREREKEREMGRERVVSGGGGIGSGAGGGSGGGGGRMGLGIEDSKDYMWIYSINNYAHISGLLDDEEGQRQGEGEGDAGGVGVGEVGDDDIEDLAAKYQEFYVDMEDLVKEWVRERVAIEEASEREKGEEKDKWKHMEKMEEIEERWTRSILERVEKVVTCGGGIYERLFSSPSPLTYSPSSTSTSSKSLPTDPHHPDASNLTAIPHDPNDQDESDASSTSSDFLEESDTAHDEALSSRIAALTMVEFSLDDLDIDVGGDEDEDQRLGKTGDQDSEKQKSELRVKRENDVLAVVQQCGQTLAQLENVKSPGEKAGFMVKAHKVLVDGLTKLPPIRLKTEQEAQLTAKPGQSDTKPTAENQLASTVADGAAMDTVKSPAIPLSTSAVDVPLHSQTAQVVPDAPEVTSPIPESPSKTTPAIPIKTEGFSEVTPRPLALAADSSSHEPSEEITDEPTPKPSKSNESTLSLDTIFPLLILSIVKTNPPRLISHLLFTQRFRNRSFGGEEAYCLVNLMAVAEFVGALEAKAVLGTREGTLSINGDGDPVAPGERAPTPFGGVPIPIPIGRTGGSVPSSRRSSRSFSRSRGKSDPALSQSATSGTSLLSTTSFTLRNRVEQQVDAISSSARGVLTGVSGVMDSGIGVFRSLTLPSSLPGVSLNGVTLGIPGLSERQRVVTPALNSTQASAPWNGVYLPGRGASGDGGASKEEVASPDGTEATRRETGFSIKGLKIPSVGINLSGVGRSSSAAKEEEMVSVSRPGSVKSRKSLGSRFGEDTDDEDEDEDEDEDEDEDEDDDDEDDQVDSEDENEDGSEDEGSEYYRSDTRSIRSFGSMMSSSKKSTKTKTKTKTKAKTREGSSGPPRQSLSDRLASVSTGFGSRGKSSTGKVPSPPASRRSSLIVANANPAASNRFDTPGSSRPQSPAPSIAGSVLRLAPPNKRFLDATSVNDLRIGELEELLKEYKRMVEAVRAVGGFVESTIAPRDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXJ1</accession>
    <name>A0A8H5LXJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gti1/Pac2 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXJ1"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034292603" description="Gti1/Pac2 family-domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32903" checksum="08DAA86D04DA8FC8" modified="2022-01-19" version="1">MDILTFLIFLLAYLSPPPVSMQQATHSRLHVRDAQDAHTVFEAVRQGRLRAVTRRLNDSERSMFVRSGSVFVWEECDDESGLKRWTDGRVWGQSRMREPYLFYDEKLPSDGFKSAEQQPKQPVFRFVDGPTRSSPGSSALLHQDRSGGHHTGLIKQAYSAFVILSPNSRPRKWHLTAYFTYADLPSIPTVDRDPLLSRITVPRGIYSSGKVRGRSDSDRSSGSPELSRSNSPPEPHMSVYRPPMDRARTLPSLHDSIGAYNFHGSNFNSLGSRLPEDHRVIQMLNSRHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BHZ2</accession>
    <name>A0A8H5BHZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000394">
        <property type="protein sequence ID" value="KAF5323221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BHZ2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5323221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="269" mass="29871" checksum="B8B8E871AD517BFA" modified="2022-01-19" version="1">MLVEGQAWEWDIGVLSESCWHCQYQQDPLAFVNANTDPRALISLHSSSQLLPHHSPPPHYLLPLPALKRIVLGNAKLQICKQLRREFRIFHICTKHSKTKVNGAVLRSISARAEHIYMHGVGLRLLRLYESTSPLRGHTPINMVRGIAQSVSEGSDFMTLNHATLVSAEKLVNSFCEYVWGEECLYQPEFSFSFLLEFRGAWFGVFVKGGVGLVSGVNSSFNCFSRGGGGQALGVKVVKEGKRRVKGRLGSRAENASISVGSWSFVIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BR64</accession>
    <name>A0A8H5BR64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000370">
        <property type="protein sequence ID" value="KAF5328039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BR64"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034584612" evidence="2">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5328039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="278" mass="28665" checksum="D637F67BF1B1A0B0" modified="2022-01-19" version="1">MMLSYLRATLSFAVLLGAFMPMMINANPIAFHTLHSASHSLTNGEQAVIDGFQNTLHMLNSKINAITPQIDTVSRPTITGGVQLDPFQAVVLNTITQAIQDATSQFTNILAGNGPISCSQNNLRQVCQQLGQQFGDIIQQIIQQLTPFAGGLGGSRPPFGLGGHGTNPPFGLPVGGFGSGNNQPASGLGSGSGTNQPSSGLSDGSGNGTKPPLGSGNGDSSPLHEIDESLSELLRSASELVVGVTGVITEVLGTATNLVSNIVQLALNLTRQILDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BT72</accession>
    <name>A0A8H5BT72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000345">
        <property type="protein sequence ID" value="KAF5329120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BT72"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="164" mass="17088" checksum="B29FD7CE491A7C89" modified="2022-01-19" version="1">MLSSVHAKVCPAASASATGKLSWPDKYAHNPGLPSQTSDTLNSLPSPSNSEDVCKCIARKREVPAWLTAISGGIYRSNPNPICISSDASTTLTPTPTFAHCKFSFSNTDRVTTKLNELSISSANAAPALSLNHNISNAGASDSDAKGEERAKRVTDAVNGASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2R7</accession>
    <name>A0A8H5C2R7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000280">
        <property type="protein sequence ID" value="KAF5333903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2R7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="131" mass="14489" checksum="059B99CC61C2CBC5" modified="2022-01-19" version="1">MYRANYLLSRLMQSDLALAKDYDICDILDVLADFILELYTPPFGWDLLYRFPRLLLTANASPTAAAPSDVLWDEALQPKTYAPTGFTWDGYLSGIVFGVYWNCVLVGWRPGGVLGGCALATPCPPYICVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6W0</accession>
    <name>A0A8H5C6W0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_014363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6W0"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5336231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="32981" checksum="8A6848C0304122B5" modified="2022-01-19" version="1">MPKRVLVGYGVDVDAVSGWLNTKTGAPPNLTDVSRGIFGATVGIDRVLKLFDKYGIKATFFVPAHTVESFPEGVGKIRDKGHEMHVSLTLSCPPSLTLFLFSFFSFFLSLTRGLHGYTHEHVSTLTLTQEKDVLAKSIEVITKFTGGKKPKGWTGPHWETSTHTIKLLEEFGLEYDHSYMHHDSQLYYLPYPPERLIPTTSGYPNGLGPSADSNIVDEVPASTWMKPMSTLKPSSIVEVPANWHLDDWPPLQANFKGAGSVSGFVDPHVVERMWKEQFDFYYREAGEERTGVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7N8</accession>
    <name>A0A8H5C7N8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000224">
        <property type="protein sequence ID" value="KAF5336722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7N8"/>
    <dbReference type="OrthoDB" id="2591449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="766" mass="81952" checksum="8ABD875A931CD38A" modified="2022-01-19" version="1">MSSPASPLQTTAPKRRLSARRGSISAPDPFAKHADLNRSLSSSSTLTIVRVLGNNNNNHSDAFALQEPPSSHSSSRRLGSQHQQHRRTGSNSSDSGSGRLSFAFSSFGGPQRSTSPTSQRRPASPGRHHALPQSQPRLSPEQLYDLAHQATNPKYFPSPGDASSPSPYRPESPHRPVSPSYFRRSPVLNAVNPSPATAPATFTPLPPSIFLPFMDRPSEVAALISSSPTKKLFALLRQTFPRDPSLPGVNSDNYSSSPQFPPLQTQITGTPIPRDPATWTYPQLMTFLTTTTRSDMPDTLWVAKIRKCILSRSELIWERVKGALGVPPELDIDANFLEDTEMHGDVFESSSGSEDEGEHEAEKRIMSRRPANVRTETDEMEDFGRKARGHWDDWDAVLSSPDVERAKTQPQFPDTSKVSTPVVDDPEILTAVAPTPRQQTSPGEKSSDLPLITEQVPTPFDEAFPPPGHTKDSKSVSSLALNPLDLDMVSGPIGSPSGASESHLIIEPLLSPSASKSPVPSANPPPLSLPSSLALEAQSGSTGALGDIIEGEEEEEEDEKGAAEQEDEDKKKDEDTPSDDSKSEPAIDPSQIHGLRISLPGTPVTPSASWRDVLFAQTQSNSSPVSSPVDSNMGRRPLSIGSSSGVAGLTRTGSTGSIRSLGSVGSRKHPYMNPSGYGEGRHFTTSSDGGYESDGVGNFARLATGPTLAANNPSLRSPPVPPASKYNPLYHSSSLRARFDRRGSKGSASGTSDYAITFGSSSVGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9W6</accession>
    <name>A0A8H5C9W6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_015681</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9W6"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="55"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5336682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="563" mass="61667" checksum="733F2C0165892685" modified="2022-01-19" version="1">MQMRIPFSLLQGRAIYQPFAQGHNGVLNSNTMPELLEVTTPSLAYICLGGFAVLFSMVSLLVKERLFINEVVLGTAFGILVGPYGIDVFDPRSWGHQSNPVTLEVMRIVLAIGLFAIGVEIPRSYMRDHAKGLLVMVVPTMAIGWLVVSGLLYVLFPQIELYGCLAIAACLTPTDPIISAAIVGGKFAVKHVPLNLRLILSAESAANDGLAYPFLSIAIYLMVDPTPKEAVLHWVLIGWLYEVICGTILGAVMGIAFAYLMRFSHRRGFIDRESYVAQYLSLAFLTIGIASTLGLDDLLAAFAAGNALSWDGQFNERTEGDVFSSVIDLVFNCACFIYIGAWLPFKSFVDFDGLGLDVWRLGLLFLGVLMMRRIPSVLLLYRWIDEIEGWKQALFTGHFGPMGVGAIFVSTLAATRLPEPHYPPENQLELVASVLQPIVSFVVLGSIIIHGLSIPFFNLSRNISVSTTVIPNLPHFPEWAWQIHRFGGVRHGADEDRDAGSERVSYHEGVLIDIDDGLEDGMGVVSARPTARPVSLCHRCSQVVESIDTAQAEEVGGQDRSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDG4</accession>
    <name>A0A8H5CDG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDG4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5339695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11790" checksum="FE95B16B23AF99E0" modified="2022-01-19" version="1">MGGSGVGGVIWSIMLNHMFNSSAGFGWAVRPATQHPNMLYVIRDTPYILIKGFQLCDNLPRDIFSILHGMQYHYWGRNNLNAGSHKLRSVLYSLEPPWLDIRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGK9</accession>
    <name>A0A8H5CGK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGK9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="23810" checksum="7F3E5334665473E8" modified="2022-01-19" version="1">MVAMNALYVLPPRLSAQQNAYCGHSYEVGNEVQIRAGLVEGYRVVNSPLLFPGSPTEQITFDVGEYVQICEVEKSTPNYPSSATNAKYRVCSQRRVHAGWKKDMGVKITNYVPSSIIEPVSPAMGQVPSAGYYDPGDVVKLSHSWAPTSSVRGNSYLKPGTFLIIRSGPLTALGKPYNYGLHEGPDGPFYVVCKVDPNMITHTFYSKDWVSPSQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHI2</accession>
    <name>A0A8H5CHI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHI2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034111815" evidence="3">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="43689" checksum="451A6C87ACEFC156" modified="2022-01-19" version="1">MKPLVLFLLYVARYSLPVSASYRFEIPPTVTVGVPIEATCIAQTLDDFKLSLFPAQAKPGQENDPINGYATDFKNPLKPDPSTGATRFVVASPGMVNKRIKFQPIHPIDNSVAFRAVDASTSSAPSTPSASALVAPAGSNNPNNGTAGESSSTSRNNDTPSSNSNTIIIAVVVTVVVVAVAAALIFIFWYRARHLKKEQRAMSSGGSGFGFVPGPGSGSEASHNFYGERMMRTSNNNMVVVPGLRYSGATGSGSEKVSPIMSYPYPGPSRQGPGSEAGSHKSYTDAPRTSFYGGSTIAPSDSISQVGYQGRFKKVMDDVDEDEDDDRDREMDGDPEKGYAESFMSIEPPARPTSEAQDRWGMTDSDSSRVAGHGHGYQGQDYSPSYNQRNLVPVRKPVPSITDSYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHX6</accession>
    <name>A0A8H5CHX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein alpha-4 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHX6"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="310"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="408"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5340882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56504" checksum="6A57EFB1207447A0" modified="2022-01-19" version="1">MRTPSIYSQDDPLTEALKPSENETEEQRRVRLQQETEARLVSERIDEDLRQERERMRKSRGDVKLLLLGQAESGKSTLQKQFQLMYKPHSLDQERVSWRTVIYFNVIRSIKHILSTLESWDDYIEGVDAGPTKYVPAVSSPSPGPSSPMMSPRTPNGISSRSNSPFTSTAAGKSSVASLRRRLSPLVAADTQLADKLSGGVAVSGSGKGNVFVRTGWQARTIENALGRRRQRPSVDVEKTEENFHDPLIEEIARMLEASKDDIRELWAHPTVKGLIAKRRMKLDEWAEFFLRHIPRIASAGYIPTTDDILHARIQTMGVSEHVFDVTIHGKSVSWHLFDVGGARGQRHSWVPYFDDANAIIFVAPISAFDQYLEEDPRTNRIDDSLQLFTQICSNPLLKSVHLVLFLNKTDLLRAKLDSGLKVKKYITSFGDRVNDYETIVQYFRAHFLQVHRKNNENRRVLYTHFTSVVDTKATQRIIGNVRDSIFRGYLQSAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHY7</accession>
    <name>A0A8H5CHY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_012199</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Plastid</location>
            <location evidence="14">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHY7"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="G" evidence="16">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="271"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5340897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="47264" checksum="35C4DDADDFF6675F" modified="2022-01-19" version="1">MIFERTTSSPGARFISTPYEPEVNTHSGFNGVVNQSSFIRTRSGVNTPAIKGQSKQDDNVVLIAVMGATGSGKTTFVNLVSGSNLRVGKSLQSCTTKIQLSQTFDIDGRKVLLIDTPGFDDTNHSDADILNMIATFLATMYEDGRKLAGVIYLHRISDIRMGGVSTRSFKMFRWLCGPEALRNVVLLTNVWDGVSLEVGEARENELKSEDKFWKPVLDKGAQVFRHDNTVGSAQAIVRYLVDKYPLPLRIQTELVDEHKHLTDTAAGAELNRELMQQIEKHRDELKTLQEEMREAINARDEETKKELEMERNQLQAEMTSLQAHSQKLATEYNEQKERFRHKVEEYQRQAEEEKRRQEVAIDDLKQQLSRNESNSEAEQGRLQKLLVELQEQYDAVQKSGVFTSVGRALDNFFARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJY9</accession>
    <name>A0A8H5CJY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJY9"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033985927" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="59"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5343206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="633" mass="67199" checksum="4A14E74399A80AA9" modified="2022-01-19" version="1">MKYLPSPSSCLVALLFFSHVSDALIFPINARRNPVTPSSSLSRRGGNITPLTNTADVSYYANLTLNGQSFLCLIDTGSSDLWVAGSVSNAKDTGKSAGVTYAIDSVEGEIKTADLVFSGYSISDQAYIEVKPSDQNPEGKGLIGLGPNTGSNVYKALNNDGGRAVANRIFLQNTSTPNFISVNLGRIEDPDDPFPGNITIGEVLPGLDSVLSQPKIDVTEVSVQQSGNQHFQILIDADGIIGPDNQPINYTSAVSSSSNSNQATAVIDTGFSLSQVPKIIADKFYSRFEGAEYVNVNGIGNTWIVPCGLEVNMTWKIGGQSYPIHPLDATLKPSIMGMTDGAVKNSNGDDCCIGMFQPISFDRGDDPTYDIILGMSFLRNVYALFDYGDFIQGSNKDRGDPYLQLLSTTDVPSSHLDFVEVRLSGDDTTGTQILNAWDPSLESSDSSTNKTSSGKNSHLKIIFLALAITAGVLGGLLLMWACCCRRRSGPNGAKGGKGVKPNAGWTAYGGYGRLGDPNANAGPGAYPFQGLSSSNSNANNSNNRQSQYDYQGETRYDPVPVHDSHGGSGNSNYAGVGLGRGDAPPYSPYDATFGQGQGHGHGQSLYDPPPQTYNPRATSPSPGGYANPFESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL79</accession>
    <name>A0A8H5CL79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL79"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="72" mass="7851" checksum="A05856FC9A847964" modified="2022-01-19" version="1">MPHRLVAKVFDTSTSAPITISTFIRDKMSRYGLDCGEPDGGETEDIMSAVVFVFVFSGLSFANENNLTACIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLL0</accession>
    <name>A0A8H5CLL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000135">
        <property type="protein sequence ID" value="KAF5343728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLL0"/>
    <dbReference type="OrthoDB" id="3235800at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="257"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="85989" checksum="58D220D1ABF66A82" modified="2022-01-19" version="1">MPKNALAQGLWIGDIPNELKDLGFAEKLLIARVRHSRCLVKVASGRYKMKANIMCFSNPVDKIYDILPLGKDELDKMIAFMFTGPSKPTPEQLRDTPLLVRQAVVKRALEWLKLNHKDYQDIAISDANLNSYDEEAVLFSYEYQEQQHNKDALTTAINEEIDDEGTESGPCPVTVHGLTGEEFGAMTSREMRAAALKHLRENKKNILYVAHNEQPVSTFHNPSLFPMMYPHLFPYGLGGINNSLQTSKIGQTVHKAFYLMYHDKRFQLEPSFSIIAFNVEQMKQSNDGGFIITHRKNINSIAERIWNIDSNVLDLMYNRFKNKERVVPSNEQEKACLQLINDVDATASRVQGSVTSKKHMRNEVWSLINKIGSPSWFITISPADVNHPICLYFADTDQEFKPYIQDKKTRERLIKQNPVAAARFFDFMFTPFYWTQYVDRVRTHWKEHDNILHAQSESINIDQSIPDEKVWVNKGNDNSFIGVSKIDDYSLRGEEIENINLYNFMSAYYKKSVRKKKPVENTDYDDETNCEERDMEMDVDKKDTRIDEYDTKFKAPSSFPSTAMFSEEHSQHLTHALFKYKNLDSRALNFAGQTWEEAFRDHMFTDTQKQLMRNFNLRYECNDARDDYSALRKRGHSTNGPAFDLDELDDEAMHEFLQNVNNTFEDNICDSVLDFNTEELLPNNSTIRNHVLNDQISKTLDNSGMMDPHVDKYNIDQDTNVFQPDITIEGSKWKQKIAEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLQ8</accession>
    <name>A0A8H5CLQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000148">
        <property type="protein sequence ID" value="KAF5343133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLQ8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="34325" checksum="5D3D68E20C6CAA8C" modified="2022-01-19" version="1">MTDSRNDVNAQGGRYGNALQAASYRGHLEVVKILCENGADVNAQGGYCRNALQGASYGGHIEVVKLICENGADIHAMEGYHGNALTAASYQGHLEVGIFLYENGADVNRKGGSYGNALQAASARGHLGVVKFLCENGADLNAQGGRYGNALQAASVEGHFEVAKLLCEKGADGNAYTVIYGNALQGASHGGHLEIVKLLLENRVDVNAPPETVFGTALQTATFKGNLEIVKLLCENGADVNAQGGYIGNPLETASFGGHSKLVKLLCEMGADVNTQGGQAASVGGHLEVVKILCENGANINAQGGYYGNALRAAGVNGHLEVVGILLEMGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMI3</accession>
    <name>A0A8H5CMI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000142">
        <property type="protein sequence ID" value="KAF5343342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMI3"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58928" checksum="1D75ECB168FAAF8C" modified="2022-01-19" version="1">MTPIPATNLYQKSNVLNYLRNNFGTFSGDVQCIRKSLHEAECDVRRYDDEIRRMEARIVSLRNEQQAILFRVDQYRSLLAPIRKVPPEVLGNIFTLCCSVESKIAERIDSPPIRLSQVCAGWRELAMTTAPLWARLNIDLNRDMDQMPSGDKMKSMLDTHLTLSKNSPLTLSVTIPSRWDDLEQAQVVIDCIVPHSSRWQDVSLDISRELLMGPIFAAIKGNLSQLQSLFLWPPSKCSISFPTTVATLDVFTSAPMLRNIQIGSLTQTEPGIPWSQLSDMGLYWQNGTTMLHRIKLASAASTIGIYWCHDVPLPDLQGPLVHNMRSLTLIQNKYGSSFRQLYDAFILPRLTTLHLSGAESEIAKVNFPTAYLHLPHLLSLIRRSQCSLTSLTLRNLHSPDDDILALLDEIPTLLSLEIHELPTEGDFDNKAITKRLLLEMTFNHRNPRANRSLLLPCLKSLSFRVRPFDYASAFVRMVQSRWIPNPDYASAMGISGLKKVVLDVLGPKGEGLKSPMDLWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN28</accession>
    <name>A0A8H5CN28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_012348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN28"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5344289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36505" checksum="853B4BA2169349CA" modified="2022-01-19" version="1">MYHNNSIRILTGNSHPELAQAVADRLNVPLVSCTVRNFSNGEIDVKIFESVRDEDVFIIQSGCADANDNLMELLILISACKTASARRITAVIPCFPYARMDKKDKSRAPITAKLVANMLVVAGCDHVITMDLHASQIQGFFDIPVDNLFSEPLMLSYIKRYIEGWQNAIIVSPDAGGAKRVTAIADKLGVEFALINRKRDGRKEDAPERMEILVGDVKDKVAIMVDDMIDSGHTLTLAARTLAEKGAKSVHALISHGLLSETNFNVIDELPIEQLVVTNTIPQTQHKTACSKLRVIDVSPTIAESIRRTHNGESISLLFEEWAESSGTVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNF8</accession>
    <name>A0A8H5CNF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNF8"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="133" mass="14798" checksum="668B4281A2094D82" modified="2022-01-19" version="1">MEYTPRYTQPFTLSEVIALDVSTITEEEIARLQNSLKHLGETQQFLREAMEVEDSDNVDAELTKAYEENQVVIGSQEERISMLKMALTEKGVVSGAHYDDADKAPESAKRIAQAEPGDSHAEVDDESSEGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNY2</accession>
    <name>A0A8H5CNY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNY2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="213" mass="23788" checksum="FFF46F21DD8C2B35" modified="2022-01-19" version="1">MGTAGLEHVKSSVQSMCLMLNFNSEFLVPAPDVNPELVLHEIFQRQLFQLYCQLKDDKPGEPGDVILDTSSFHPLYKDERRKTPVWAVDHISSSHCPTNPQSLFLNQCDAPAPSRSSKRSLQAKANVDGDEGVEVSEELDEVDDDADSQRESKRRRMQNGQSSRPSTAAQSTNVPLRRPKIKDQMKKRGSATRPSLIHRSQGVMMRGRMGGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPH7</accession>
    <name>A0A8H5CPH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPH7"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="44"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5345039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="466" mass="51268" checksum="128D7D8E6F8795A2" modified="2022-01-19" version="1">MSFEDVNAQKKFDVENGVESDSSSQDSVGIQIAREQDHAIQYRTCSWQKTAALLFSEYICLAILSFPWSFSILGLVPGIIVTVAVAGTVLYTSLILGRYCIAHPTLRDIPDIGRELFGGSEIAYNITSVFFLLNNTFIQALHVLVGAKLLNTLSNSAQCTTVFMVISAIVCFVISLPRTLEQMSGMGVFAAVTMGIAVLLAIIFAGIQDHPFGYIPGSEPIVTVIPVSGTTFVSGMSAFLNITYTLVGQAMIPSFIAEMKNPKDFPKAIWAVTLAEVVVFSICGAVVYHFVGNQYMTSPGFGSLEEPYKKIAFSFAIPTIVFLGSLYSSVTSRFIFFRIFRKSHHLHSNTFIGWATWVGIVGVTWVFAFIIAEVIPFFSDMLSLMSSLFDGWFGFIFWAMAYLSLYPGKERWRGPLRSAETLMNYFFILLGFYILIAGTYVSIQSIIDSYNAQTVGGVFTCASNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRJ8</accession>
    <name>A0A8H5CRJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRJ8"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="254" mass="28466" checksum="61DD74F28B768A55" modified="2022-01-19" version="1">MWALSYFQTCHAATYHQSLIDHNHLYGSSRFDTWEEFEKEFIREFMPEDERTQASLTLEGVSYFQGTASVDEYIDNFRALITIAGLNVEPVLYSTNPTAPIIKARLEDAKHVGQTVVLKFRCGLWPALEKKVAEAEARPQEWDIAAWYSLAKRFYKHEREDAIFHGAQRSVHPGPPKPTFPSHAQPQGRSLFPIQFPTPAAAPIPAPRAPAPAQAPLPQGIPMEVDASRQRFLACCTCYTCGKTGHFSAACPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSH9</accession>
    <name>A0A8H5CSH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSH9"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="23549" checksum="B5CFAAD74E6E9DD9" modified="2022-01-19" version="1">MMSCHLTHDEAVVDTVKRELSKYEIVHLACHGIQDSINPLDSAFALNVGNLKLQDLMRLSLEKAELAVLFVCQTATGDENLPEEAVHLAAGMLAVGYPSVVATMWSISDRDAPIVADKVYENLLGHRDELETRNPSQSAAYEHLRKEVGTAYALHAAVKYLRSPWGHHDKLVTRNPRQSAAYALHAAVEHLRKEVGEMEFVKWIPFVHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUN5</accession>
    <name>A0A8H5CUN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUN5"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="781"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112555" checksum="FC92D36723C28036" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILVAWLQATGLSSVLRSERPDDAEVSTASPLSAEDAAAQSEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLGMTTAKEIWDFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAYGIPTDGTSTTSVTKVANFLIVMFIISKLPPRYEYLINQYTQYTLEEVDNANLDVLQSEIVNIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQHQQQQRPSGSSSGANGASGSNGNNKGKGKGKGKGKANFRRGGRAGKFEQAKRQGQAHLVNDDMSPMMHTVTVVNTPAAVDTRTKRAINLARDIGARPSGETVATLEDVVMSHTDPSSFTSLTPAPRPKRSLTERIYWNNLQSSTDGWGDAGNWNGWNGEYPESQTGSDADMACAQGEDASWNEDTLVNTSELGSVFGTTTTESGVKVSQDIRTPVPLIDRIAADPAAEMMECAMYLGERFQNPEDPLHIYGEPLRTALNTVAPTGTRGTLSLVQRLAAVRSEMPSGSQPAPPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGGMELPSRAPTPSSMPELRSMSPSLSETSDLEYMSTPPSIGGMSLPTSPVEDTASYGIPSPRPSTPVTVTVNAGNNYGWSLDSEPSGLDNGYLRSDLNLDLMNKSTDALFPAARNLEAGSSCIYLLHTAPLGLTTPFIYNDLYTSPGGNNKYLCACGTLFSLCQKCKKKRSDTVKIHFSDGWLLDSGASAHFTFDINDFVELSYIKPIPVKTANGFTKIRASGTVLISQRKRVMKLYPVYYIPDLNQRLLSVGQFLNDNMFMHDFHHRPPRIPSTRRPDQPRDDEPEQDPPPSSPDSDSEPRRTVTPPPVETPPSQAPRKPRAPRQRRPPTEPTRRSERTGTVPKRYGDRHPVEVERDLEPQIAADKRAEAKAKAERDARRERQQAAEQQVPGPSSASGSAPQGSSKPRVMTLHALNQKKWQNHAVKGEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW10</accession>
    <name>A0A8H5CW10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW10"/>
    <dbReference type="OrthoDB" id="3234968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="151" mass="16030" checksum="54753DC778B8E448" modified="2022-01-19" version="1">MNLFIPFSAGVAIYYYAALWPWNISTILSLDGGPNELVDLRDKSDAGSLNATIHAKSTQDFDVRWWRDGLINEEHTLVISMGDGKLAQWAIVDRLAFTSINSSTSTSTLPDNSVAPTSSPASSASTRSGSKTPLIAGLVVGIIGAILLSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZE7</accession>
    <name>A0A8H5CZE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZE7"/>
    <dbReference type="OrthoDB" id="3059875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="34216" checksum="5B102CDA2976534C" modified="2022-01-19" version="1">MADNISTFDNDMEFIFSDAEKSVNRLNSLVSESLRMCLFKERILHYTKIALDICEFELPISADNKKSSIHGWNHSQLARLLCIPTKLKDFDEDPALLSKVQENTIKISGNHFPPCFYWDLGEEALKGPGFVFDHLLTGWLIVIMIMFRAEANKVGKGLSHGATTVTYQGIAYATLMVRHGLAATNSWHHEEGGVIKQSAFDAIIALFEDPRLMSPDWIETTLGTWIDSDDDLDSSINAVAEYVLQEQIKKAFAAVTLIAAKAGSLNPSPEGVSVLAAVAQAESSRGLSLSLPTTGSSALTAQSTASSSTHGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1T6</accession>
    <name>A0A8H5D1T6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1T6"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034852294" description="Hydrophobin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5351534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="106" mass="10415" checksum="2E9FB16BCE120998" modified="2022-01-19" version="1">MQFKLLAISALATLAAATSAPASQCNTGNLQCCNSVQDANSGIVSTLLGLLGVDIGSVTAQVGVTCSPISVIGVGGNSCTAQPVCCENNSFNGVVALGCTPVNINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5M6</accession>
    <name>A0A8H5D5M6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_008710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5M6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5353161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53364" checksum="908C89590E0F97AD" modified="2022-01-19" version="1">MVPYRHLSKYIPSSTAAVFAFFLGSVFHASDEQRGHLRLWPIVDGSRQRQRNRRSYSLANLPGPKSRSWWQGNLGEVMNADAWKFHERLLKEYGQVIRIDGFMGDKQVLIFDPKAMHHVLVKDATMYESTNVTASALVIGKGLTGITGNAHRKQRKALNPVFSIAHMKDMLPIFWEVVDRLESGLSAKFTNDRSGSQPQEIEMLSWMSRTALELIGQAGLGYSFDNLSTEAEAHPYPGILKQLLTTGSRMWFFHKYVLNWTLKIGTPGFLRRVLDMIPWKDGHHMRDMSDYSWEMSKQIYEHKKKALAEGDEAVAKQIGKGKDIMSILMRLNMEEEDGGENKLDEDEVLGQMSTLVFAAMDTTSGALARILYLLAAHTEVQDKLRREILEAQSGNKHISYDQLVSLPYLDAICRETLRLFAPVSYIFRYALQDTVLPLSAPITGIDGTLVTELHIPKKHPDHDLHLKLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6M3</accession>
    <name>A0A8H5D6M3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6M3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="21553" checksum="ADD15B3D3F54AA22" modified="2022-01-19" version="1">MLEKDRDVLAQEKYVRQASLSPARKDPRAFHFTAGIPNQSLTCLSQFSISPILAVFFAISPSRPDFWSHIILRFDSLYDNKYLSRNSEICYWPLHSVNIYPTPNPPHLPSTCIIGSIGTRVMEDMYEELDADIADDKEHQRRERLVFTSLLWEILTILLSEASRWRSASLAVEALREGQKGLRANGPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7Y4</accession>
    <name>A0A8H5D7Y4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7Y4"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="3">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="4">
        <location>
            <begin position="535"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="4">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5354391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="670" mass="75640" checksum="244B32FFA0F0876C" modified="2022-01-19" version="1">MLLKKSNPLSKTDLKTTIWFNFSLISELSLKTPSTPVLLTPPFLLTRPPLQVFPTVHPVPPLPELVINQPWSLHPLLQPAQLPLPVTKPPTQTPNKDFFYAQGFKAHRSKPAEMIARYLDKAMQKGQGAQSTKEYERTLDKAVGEEVVDWEECELGCGAENGYDPKFDLGESMFNDLKLLEDLMREYPVWEDKTKKDELKAKYKKLEQDKQKKNKDIDVDKIEDALAYDGGTQCLAFQRPEEENHSIFGIRFWVGMGLGEGRSVVELKETRLRQRDTTTNTDVTSRLLLTLAPTILTNQWIKMRLWGVGKVDDFVGKLWTGWKALRDKGLQQIAMFQYVFNTISSSFSTLSQKVSEMHRHVHLCASTGFYDSSPYLQADNLPPNDTIAGPVEGLAAAHTAYDVPRYVSLLNICLLLSLSCTQILFIVQPGERNVFDQLWLEYELLEKHSIKVIRLTFDELSSCASVSSINAPLFTTSSSLHFPPGASPSSKFPLSTSAQPTPPPTSPPHPTTSTLKSLATQLHRHPYGLPPSPSRMELIAQNKLNDVMEVGVTRFHFSIQENNQLPLNFTHEYQAANRYSLHQPNPIPSWFRRACLENPRPLPDFTPSTWHNFVVQVDWDQRTLQVFYSTDGETLEAVTDVVQICQMRVLGVSAGAGIQVTHAQQDQDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9X0</accession>
    <name>A0A8H5F9X0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000345">
        <property type="protein sequence ID" value="KAF5329126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="268"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="712"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="496"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="709"/>
        </location>
    </feature>
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        <location>
            <begin position="747"/>
            <end position="825"/>
        </location>
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        <location>
            <begin position="872"/>
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        </location>
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        <location>
            <begin position="922"/>
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        </location>
    </feature>
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        <location>
            <begin position="977"/>
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        </location>
    </feature>
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        <location>
            <begin position="1143"/>
            <end position="1250"/>
        </location>
    </feature>
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        <location>
            <begin position="1297"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5329126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1418" mass="150664" checksum="030B63315051F344" modified="2022-01-19" version="1">MLQGTLRKENREKITGCTGSEQRERTKDVTGGHLIVTPSVSTPTRSCILARRLLSSNPTSSSTSAASSSLLLGSLSDSCIPLSYPESQHKPQKPFVFRSQAPPAAGAPPAPGVAMSEIPLDRAQIMQLLTTLPFAKSTLTTAEGTLKEDAAQQLIANISQNGFAAALANAAAAGQLPHLPPHGAPGFPLGDPGPSSHPRGPPNLGQLSAAAMQAAPAPPSQRDSDGEGDDHDGSNPDAPNAPPTAAPTGGRRGGRGGAAMGSDEWTRQRKDNHKEVERRRRGNINEGINELGRIVPNGSGEKSKGAILSRAVQYIHHLKENEARNIEKWTLEKLLMDQAMGDLQAQLEDTRRAWEEERTGREKAERELQDLKKNVTSGTKRPNEDGDGKDDDVMASPSTPISERPSNTLVNDSPNTSDGVDPALRAAGLELKNVWDRCKGVEASRVNFAWMKELGAAIERFDKANSQQPQSSRSSSSSSSSPSSSSSSSSPSSPSVATATVALSPTMKNFLRIKDDAERYILPFLRAGDQNLEWCCRKWRAHAKLLKPTMPPSPSGEPGVGASLSNFGSGSGSGSGGKDKDKDIEREKEKDSEVDEIKASGGEEESGDVTNGDGEQDPQYRYLPFAAAQLGSNTIFTPLDAYGSEDGDAESRVSSPGLDPHSNPNMSPSSPLQPSSLSPVASLMLKSNGTSMSTSTPSKAKSNPNPIPATHPCSECIKRGIECTRRPDHPKGACTNCFQRNRKCSFVGEEKKQKSKQKQKQAQSERNENGKGKGKPDELLNGTGVGLDNPISSSSRKRNAVDVPLSTPRLKKPRTLGHNGTRIKTSARGRSGIDVCLRCQKYGLECVLDGPRGERGACKNCRVRRRGCFFKHGGDSAPSGAGPSTTSASASRGPRIPKTDFTSTPGPVKGGVFVDVPQSPFDRSSYISPTSTRSRSSSLTTLSRASSVSLSGSDSEHSSSPSNLVPVPIAVPAVFSTKCQRPNPNPNPQSQLQPKSKFTSKPKTVSKKKSMTYGRKLLWTVPPGPLQTKKRKAGSESQTQTQTLGRVKGSDRNASAKKRRLSEPSDIAASISKAAKEKVLLDESGKEKHSTKKKRKAKGQSQDKGKASEIGEKYCIVDDAMCVQNQKWRRGRCQACRELQASLKQAAKGTETETGTGTVAASAAAAAATSKDGVPSASTRSKSITDKDKQKDNEDETDTDTDTDTDTDEGLSDLSDLSMSPLRALSGSISAPVGMRRDKEKRVTSSSNKSKKYCVANDPLCIKNQGWRRGRCQPCRKAMLAAKEANRAAVAAGLIPAPDAVAGPSNTQDKTKSDNARGSSPSDTAMTDDEAPKAAASQAPKVKRCDRCTKLDLECVPAPSMKVPTGICASCRDHRRKCSLSVGKARNGGFVPFIPSPSVRAATSTSVPASASAPVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FBA9</accession>
    <name>A0A8H5FBA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FBA9"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5330088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="607" mass="65096" checksum="9A8A2E2D16367CAF" modified="2022-01-19" version="1">MNQKSESPKHTGGNEEEKDVERTRRRRKKGNYVIDLSLNVNVNASSVPIRRPNNHKQQRGIPDSETTPLTAKCARNSRADGICCKELKADVVRDVLIGLIGLTVPFAVTAGLSSLGASPLVSELIAGAISVGIGEFLASQAEHDHYRYLKNQTASWVIRSCAGTCRAVVKALREGGTPEQRQRFEETGGGLRWSKDVGLTALLLKFGQGLEVPTPCLYISVFTIGLGYLIGGLIPLFPYFFIPQASTALVYSEVIDISTLLYFTLLYSAILSDPRLCAFISPILFRLYLLYLLAFIFFIFSPLSSLSSRLYLLYRLAFILFYPLSPSAKPSSNTHVNRSLEHTHPTLPLASGKVSLGVQCRLYSLVGLAARAVFVIVKALEGGGERTLIDPDVVRDVHIPPGRPGGVAILITGAISMAARVIRSCAGEMLGPVGVDEGTCRAAAKALRGWEVPTSRLYISAFTIGLGYLIGGLVPLFPYFFIPQASTTLIYSCVVMGVVLLVFGAIKTQVSNRYFYSTPLSGPHLGAFVTGAYTSNSTLGVWKGIVWGAVSTLLVGGLAAGAALGIVKALEGGLGVSNCATLETDRDGIGLGITVALYYTTTVEVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FE46</accession>
    <name>A0A8H5FE46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FE46"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="45009" checksum="48F4E758FE74C072" modified="2022-01-19" version="1">MKVFSDGESEQERELERKRERGREQKKVEMKSETRNDHNPNKDEEVDAVVDEDVDADLGLESDSDHESSTLDFNYLADTFSHTSSERGLWKDDPPATHWNRPTAAQRTLLESVSDSALLTLSTLAEEALRAPDLDLQQLPRSFQLHRLRAQELITSPTVPNANTGRRCSTTTAYSYSSASSLPPSSPPTSPLSHHGYMEVDADNDHGMDMDIDSGMGVGVEDNLVRQDGGALKGIEVLESKALTSYESTDGSRTDNVNGYDHEEQSHRRTEASEEDGVQIETIQSDEKQQPPSSPPSVFSVLEDSGEYKTPSDEANATPSEPSHSMEQSSKDRIRMVSPLPPSPLLSPSLPLDLPTPTTTTIPTSIPSPGPTLAVLTSHLESEPEPEPEPEPPVNVDVQTFSTLSILTILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFF4</accession>
    <name>A0A8H5FFF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="739"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="922"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1166"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1240"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5334844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1415" mass="159262" checksum="48FB92422DF65658" modified="2022-01-19" version="1">MGIPKFFRWLSERYPLTSQLIEENKIPEFDNLYLDFNSIIHNCSHPNDDDAHFRLSEEQIFTSIFTYVDHLFGKMRPKKLFFMAIDGVAPRAKMNQQRSRRFRTVKEARETREKAEAKGEKLPEEKAFDSNCITPGTPFMARLSEQLKYFVNKKITEDSNWRDIQVVLSGHDVPGEGEHKIMEYIRLSRMQPDYDPDVRHCLYGLDADLIMLGLLSHDPHFCLLREEVKFGPSRKSKNNTLESMNFYLLHLCLLREYLDLEFHSLAETLSFPYSLERIIDDFVLLAVFVGNDFLPHLPDLHIHEHGLERLFEVYKKALVRMEGYINDAGTINLERLQVVLQEMGAWEREVFEREYGDLNWFKGKQGKHVRAAENAINGKVQASLTPSQKGLFDQVKGYVMEPGKSREKQPLKMPNTFPARDRKFLTTLAGDLNLDVAWDDYDDDGNNLVTLLPALSPEDSDESEDEVAEAESQAAIFRVIKKYDTAPVSGEPSEQDADDRTRQKMDEWKRDYYRGKLEISYDDPEQMRKLVYRYVEGLQFVMFYYFKGVPSWGWFFDYHYAPRISDLDLVGKGGMDLTKTIEFDLGDPFKPYEQLMGVLPIASKDHIPRAYHDLMTNPLSPIAHFYPLEFEQDLNGKKQDWEAIVKIPFIDAELLRASMKKKEHMLSKEEVLRNQSGKTIRFHYTGPEHATEYPSSLPGFFPPIYRCTCRMEEFELPTMVPGTPLPLIGGVASESPSGLLAGFPSLKTLPQTHTVLGHHHVNVHGTESRNQSVVLHIKNKYEDMKSEQVARQFLGKVVHTGWPFLREGKVVGVSDSLFKYDKIGIAGKEKVVPTPHAPNAIGHWKAKAERIESVYSKRAGVVSGEVEIMLHVRPLKGLNRLETGAFIKEYEDVNKEIEQAVQMVVDRVHAEDPRYIEKPPAPLSEEFPIGSKIFFLGEHAYGVAAQVSATTHTALSVILAIFPEETTENDQFKAIVQQRKSSIYYPSFRAADMLGISGRALSKITSSFMVLTSDRSKHNLGLSLKFEAKSLKVIDYSKKDGRIWEFSEKAIELIKAYQEMFPEIFRCLDQSGNAMATAADILPGPDPDARVREIKAWLKQKGVRDFEQVSLFCDQLSKDTVSEIEKLADSFTANKSAKAIKKAIVKGIPRQAVLKPAHAVYRLQNQHFALGDRVTMVQDSGGVPLSVKGVVIGLNTKSMDVVWDVPFMAGTTMGDRCSQYRGCTVEFNSCLNLSHPQFVTSTNPKAPPAPPAHTTPFKPMFGPHPAVNPPPGQTPAAGFRPAQSNPAPVHIMTNPNRGGRGGMFVRGGAVHNHRAGPAFVPPTQSDNHHEPTDSPNGINSNPVNGINGANHINHSPGSRGAHRGRGGYGPPPTYRGRGGAFAQFDRGRGGLPSRGGFRARGRGGFNGVSSSDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFL1</accession>
    <name>A0A8H5FFL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFL1"/>
    <dbReference type="OrthoDB" id="3026831at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="538"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="652" mass="72689" checksum="E0B4FFFA7E3C1191" modified="2022-01-19" version="1">MAGIARNFFQNSSHFTVYGLNINMVEGNSYRYDMDPGGLTGDAGGLEDGEFEMTDKPVLSIQVLEHAPTFCWMKGYHSVNLLGTIFKTEPQHTAMFFKSPFLAIRGTRELQGKAAHRSFDSLEQRQEVCRGRVSVESDFSCQRSSWSSCGFGTDAGSGIGYFSGESFLYETGSHQEDSNLALVGRISSSHPTLGSRKNIKSATTRFISCEDVQTMKKLHRGSSFQVYSAKHKNRIVVFKEFFGSRAKQHLQQVLNLSHGLMDPCFLKVKGISTSESPTQFIVFDNACSASFELNVASALQEDQTQSVRIGFAIVGGLSAGLSYICRKGIPLSLFSVENLEIYVTDDDELKIGSAPSKTDVAEAPGDAQEDRLWEIFNQSCLNAFERANRLLYPKVPPQSLVAIVPASENETISERSNFGESSPVAHSSKPRRDLVWEAARRRTSTVELVAQHYQDYLDITRLKPVGSFALRQLKAQTRRLILQKLHQCPSYKREEITFTTTITENAIISHSTPFNGEICYVCGEQVGESSLFSPKATKGRVKGPVDYDKQCGVINDKGLPCRRSVTCKSHSMGAKRAVQGRSRKYDDLLLVWQREHNPNFVEPVKKQRRLKEEKEKLEEELAEEAAAAMSLDLTKKVEGGRMGYMYTYTEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFV2</accession>
    <name>A0A8H5FFV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000244">
        <property type="protein sequence ID" value="KAF5335264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFV2"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="207" mass="22972" checksum="798A14BF5052DFF5" modified="2022-01-19" version="1">MSSRARLVAFCRKMPSITYDQLRQTWLYDVGSRFATLEIAQKNILVYEQGHIDQTALQRLVQDGFSVPDFDGFAVLEAESFEKIQEVLASEEWKTNVGPIEGSVIDITSPEVWPCASVETIGESGVKGFRYVVFDGGNINRETCDHFSMLQKLIKMSLLKMVSGDAGGNKSLVFIETDSLEPSSRPSALSNCEGKILPAIVETIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIB6</accession>
    <name>A0A8H5FIB6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_014922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000213">
        <property type="protein sequence ID" value="KAF5337617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5337617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1876" mass="212077" checksum="CD01D8BA5509E110" modified="2022-01-19" version="1">MEGRLDMVVDGRGETRVGHTFRFSHLPLLLRISSSPSSPAQGGSNRFLFTTIMSSLSSFFPSKFLSSSMNTRDRSSEPLSHLRFALETMPGNRKYQFTNLTRAEILHELYEAFWGPYSHLFLPNSNSSLPMHALLNEVQVSQGFCGAGKEEPLIPGRPCAHILKKGEPCYRCKDCALDDSCVICSRCFHATNHTGHNVSFFIAQQSGGCCDCGDEEAWRVPINCPYHPPSTSETPDPSTTSPASSSTPKTRTRTISDVIPPVKNYPYRVNVPPELRETMNRTVGYALDFVLDTLDFSPDEPSVPAGEADLRLQPSADPMMKDQHCVVIWNDDKHSFDEVIKLLCDLTSRTHEEASESAHRIDEEGRDIVKMSTDVTLLLEIAQNIAQIDLGVTIRRAYDTFREQIAAVIIEWLLDLTQSRLATDTLILREVIAEELLSPRKRDHNSYMYNTHALHSLPDIPNLTRLDCLFLCHTRLWKKPRLSLKEIYTSILTLSRDHKLAVAGHFARVYHRVIDAYLLVDREAETSIKYFALQLFTVPSVSYHIVRHHKLITRLLAIITAFFTNQIMDKRIAYPPLTNNTVLDVDTFPFKSKRFMPVFSDLRYLCHNEPVQHLIAHNREFIVQFAKTCQLFMCVNPNKRAVTNHVEFETDAWISVFNVTLSLSRVIKVYGQAFSKASTAELVSAITTVVHHILMVCTLAEDRLDRTKFPPIAFHEIVFGDTAYSIIKFDVLEGWVSFHHSLHWLLAELFKHVDLLTEQKLMEVGMTRVQDIMLRHASEQAILTVVDFPLRVLAMIAQIRTGLWVRNGFAIRGQLLHYRDFMLRELCYDQDLFILQVALVILDPNTIIVTILDRFGLLQYFSGAFVHGTYDATQLASMVEEVLYLFITILSESASISKMPIEDQVRREIVHALSLGPCTYSDLVKRVSERLVEDVCFERVLKEITNFRPPESTSDSGMYELKDEMFDEVNPFFYHYTRNKREEVETILKNRIKKKTGVADPVLIPKAMEVKTGPFAIIPSTFESEALLQVMFYAIYNVLVGTESSGGTAPPSGEAILDQVLHLIMLAIVERAAIFCALAAIKTFEEEKTLIDVLCTLEHHEGYKPYKARVAWVLDQIQNYVPHEVRSRRFVPPDKGADAPDPEEMRKRAAKARQEAIMKQMKAQQASFAINFDDVDDEEDEDMEDAQQEEVSYGTCIVCQEDLNSMRSFGMLGLVQPSRSIRRQPDGFTIYLNEVLQSPPSLDRPVGERITTFPPPDAEAIDAKAGSSPNYDGFPAQYTRFGLHSSVCSHMMHLDCFQVYSISIRQRHRTQATRNHPEVIPRKEYICPLCKSLGNVILPVAKALSTELNTVPFPDWIRSAGISILKSKPDSHLESLQFRNGTGEFVFWSAQDSGYSVAMRNAERDATEATKMVDTVMTVSKSFSQQTRHLRERHEPEAGERGAGIYLPEELIGYTIASMEVAQRGSGVSSSVVADSLSEAQIQMIRGCLNVLTRLAAMHFKGRPDEGREAVKQAIIKRLLPEWSRSSLTSFSFPLLLRDPFTVLVEAAAVAPDIIRHVLVLTYYACLARTVIGLVFVLNKIRSYNTAQLARRNHEDTFGDVRMFFMSVVRHSPVFEHTATLAFETFGEARIEKLLYAFTLPFLRKAAMLCRAVLPHSFPTPDFAGSDVNEYSRLLQFLGIPQLSDLPHQDTLQNALSGWCAHYGHSHAASPLNFGVVLDLPCVYRLARLPLVLDNLFVDPDKLVPCTRCNTVPADAAICLLCGATVCFQSTCCADMDERRGECNMHTRECGGALGIYFLVKRCIVLYLYGNSGTFNQSPYLDVHGEVDISMRRGPRQYLHHARWEDIRKTWLNHGIPTVIARKLESSLDSGGWETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJ76</accession>
    <name>A0A8H5FJ76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000194">
        <property type="protein sequence ID" value="KAF5338577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJ76"/>
    <dbReference type="OrthoDB" id="3058388at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="758"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5338577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="839" mass="94304" checksum="06C7C02E722DDE6D" modified="2022-01-19" version="1">MVEHDRPDPTLVLPDGSRRQHKRKQRIDGSEDATSSTHQPRGTQKARKTNEKSTPRRTHSEEGAEPTQATTSEPDPTPTLPDPTLATNPTYTPTPNPTPTPTLVNPGPTVIEIDDDENETTDLKHRFSMPGRPKSSCVADHPQFQKKESLVYTFLIMVEPEHEEGRLVSCEMACGFCSAKKLPEKKWKWNISGRGSTSNFLNHFKAKHTNVWTARNTEDMSARFPNRSTAPAEGSTQQLTLHSWTNKAFDFPMADRLLAEWMVLSCEEFLEVENQAFRRFVTHLRPAYGARMVKADAAKNHIHGEYEKAEKRLKEYLKNAPGKKAFAADAWTSNNNLAYLAIVVSFITEEWEMASLLFDFPHLKGQHTGKNMAELLAKKIIDYGLADDFSALAADNASNNDTLRQELASILNEASQRTWYDPEEMTVRCLPHAIHLVVRAFLIELKAVGEDDIDPNQVEAPGSAGLGKNPEETAEEVTVQDEGMAEMSDEELLAAQVRDGIDVEVVVQKIRQISKLTRSSPQRSEEFHKTISIVNAISNPSVKLRLLNLILDIITRWNSTYFMVKRAKELRAAIDELCTQNDLYKKYKISSEEWEVIDVIVEFLELMNAVDKFMESDIAKKNTSVQAGLVACKEKLEKYYDKSTYESHYYYAAAVLDPRLKHKLFEANPNLFTRDWRHRMETAFKERLTLYSAAAPASTANPSTTPQTPFVSNTNSRSSSIDDLFNDESLLGSSAGSPSATETAEEEYARYLGDRTTNNVDCLAFWKTSGKFYPRLAAYARDVLAIPGSSVAVERVLSVGRDLIGLHRHSLSAETSSELMIHRSILVFEGGLTEDYVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN89</accession>
    <name>A0A8H5FN89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aryl-alcohol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN89"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034000493" description="Aryl-alcohol oxidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="9">
        <location>
            <begin position="459"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="579"/>
            <end position="580"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5343031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="64726" checksum="8DB4478802A67C65" modified="2022-01-19" version="1">MRLLCASTFLLALPAFSRLLTSISELDDLKYDFVVIGGGTAGSVLANRLSEDGRHKVLVVEAGVDNANIQDIIVPFLGPGAFNSLVDWNFTSIPQTEMFNRTIPLPRGFVLGGSSSINFMTWNRGSDDVWDNFARLSNDSGWSWDSVSRLTPPSDGHNTTGEVIPSAHGNGPVLTSLSGFATELDPIVSGTARSIGGRFKYNEDPNAGDMIGTSFVQNSIGHGARSSAATAYLVPILHRPNLDVVIHSRVTKVRASYPAQNDIPTIDTVEIAHSATGPRIEVTASREIILSAGVFGTAQLLMLSGVGPKEELEKRHIPVVVDSPDVGKHLVDHPLLANYFVVNSNTSFERVLRNGSIAEDLLGQWEANRTGLMVDPAAGNTAAFLKNPADLFPKFDPSSGPKSANIEMIFCNGFEPLGPTSLPSNGSFMTVITAVVSPTSRMNLFSFISDNFSDVFIGGTLTLNSTNPFDSPVIDPRLYSTEFDIQTMVQAMKDVDTFVSESAWEGYIVRPFVEFSNDEERAIYARNNSITVNHSVGTARMGPGDGTDGVVDSSLRVKGVNGLRIVDASVYPQIPENHPQAVAYILAERASDLIRSCHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNV4</accession>
    <name>A0A8H5FNV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNV4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="4">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="293" mass="31821" checksum="9764611F9F13F0C1" modified="2022-01-19" version="1">MSIHDVNTGLGGLDGSIRFELDRAENVGIGMVNTLLNFTSFVSPVISMADTIALGTTFAFAGCGAPYLIPFRGGRIDALSAGPPGVPEPTQSLRVGIRWVELRGLIFLMFDSEEEGDFGSFTGVIKAPQPYNQSVATRYLDGTTQNPLAVSKNESFRSDGSIFASDGNVTMKRLSESKQTFDETCKNLIERMINTVPKNVTLTDVILPIQNKVGLSEFSASTDPKEDDLVFTITLRTIDLPDDPNRTVTFFWTDRRASDSSSSCHHQVACTLPQPPPNSLSPPPHSLIKAYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUF9</accession>
    <name>A0A8H5FUF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUF9"/>
    <dbReference type="OrthoDB" id="3014170at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="285" mass="31680" checksum="820B4AAAE4DBE774" modified="2022-01-19" version="1">MAHANPPLTGPGNNFNNRGNQFNNTGSGPQNANTDRGVQYNNTGPGTQNNSSKVDDMKVPLPEGFVPAVIELAGRDRGDPNGAWTDPTSEEIVEIWNRLSPLDMVNKFLYYKKDITETVTRELTTWRNSFGEAAIKALNLKFPGKLNREDQEYIDDQTRGNLADRECYYLYPESGFLQSPIVAETFSEHVKAIGSNSVDQFWKENEPTSALVLTILAIERAFRLRSSSSTNSISQSRELSSDEETQKLTSAAFEIVKKVPKIEWEIIVGAAKKVDESAALPRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUZ4</accession>
    <name>A0A8H5FUZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUZ4"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="27389" checksum="6F04C829FCA6B166" modified="2022-01-19" version="1">MTIHFQPLDDIDPLRHYHEGYSLRPGYCCMPCEVPYSPECWPAPINVPWSTTPIPSDVNVDSLNTAAAPWTPDQYDSQPEITNFYKHWILNPRLNGLTLEVSLLEPKAKAWVHVSDGAIFNTHRPRLGVVPANICGPLQWPSAHTEQGLMVIIVGEHTGLLVRRVYYCVVGGESHFIVRGVDFTGSDRQERMTNTQLVLHPSWLIRVMESKADKERGKKVFEAIRKEARRRKPVYLQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXP2</accession>
    <name>A0A8H5FXP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_007961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXP2"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="355"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5352991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="468" mass="52547" checksum="20D108D612A098A8" modified="2022-01-19" version="1">MEAFDTYQTPLSSRYASKEMAHLFSPSNRFYTWRKLWLNLAIAEKELGLSVSDEAIEQMKANLHLTPEQFDVAAKEEKKRRHDVMAHVHTFGTVAPAAAGIIHLGATSCYVTDNADLIFLRDGLDLLIRSLTVLISRLSSFAEQYKSLPTLGFTHFQPAQLTTELLWDLRNIKRAREDIGFRGVKGTTGTQASFLALFDGDHEKVEALDKLVTKLSGFGYAYPVTSQTYSRKIDVDVLGPLASFGATAHKIATDIRLLANLKEIEEPFESTQIGSSAMAYKRNPMRSERVCSLSRHLMVLHQNALMTSSVQCANRRITLPEAFLTADIVLSTFQNISEGLVVYPKVIARRIAQELPFMATENIIMAIVKKGGDRQEAHEKIRVLSHEAGWQVKMEGGENDLIERVKKDEYFKGIWDDLKDNDGGLLDPKSFVGRAPEQVDVFLRDWVKPVLDEAKDIVEMAKKVELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYB0</accession>
    <name>A0A8H5FYB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dicarboxylic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYB0"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="215"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5353666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34015" checksum="93729C96B51B261A" modified="2022-01-19" version="1">MASKSTSTPVKVAEPMIPPSSAIPPKKKPYPMWLGGIAATIAASITHPLDLTKVRLQASGDKRMIESLKKTVRTAGVRGLFDGITGTWMRQMSYSMCRFWAYEESKKFLGAGKDAPAWKLGLAGSMAGGIAGFVGNPGEIVMVRLQGDFAKPPEKRFNYKHCFDALFRMVREEGASSLARGVGPNVFRAILMNASQLASYDFFKAELLKTKYFEDNIACHFTASFAAGTVATTVCSPADVLKSRIMNASGPGSSSTMAAIRTAIANEGPMFMFKGWVPAWMRLQPTTILIFLTLEQLKNLVDYSRSKGHDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYL5</accession>
    <name>A0A8H5FYL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYL5"/>
    <dbReference type="OrthoDB" id="4773000at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="36666" checksum="F94987CD0625A116" modified="2022-01-19" version="1">MSPPVISADPTPVTTPVLDPLQKRTRPRRLINTCTRKLEEFPSDDSVPCYAILSHRWEAGQEISYQEMVHLSDTLRLKSGYKKIVNACNLARQDGHAYIWIDTCCINSGDHGQRSQDINSMFNYYEHSGVCLVYLHDYTTPPDSNDYLGGPIDSDEFDNWKPSPELEDSTWFSRGWTLQELLAPPSVLFITAEWKPIRVGMKLLCSDIQRVTGISVDVLVGREKINTISIVERMSWAINRQTTKEEDRAYCLLGLLDVTMESRYGEGVESAFERLSNVLHECYPDRLEGVPKTGRDIMEYLSVKNAETQNDPGWFFENPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYW4</accession>
    <name>A0A8H5FYW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYW4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034292921" evidence="3">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5353818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="273" mass="29211" checksum="FCA71D2766D6CCAC" modified="2022-01-19" version="1">MAIIMMMISFASLVIDFEFSLVQIPSIGYNPPDPDWLARVMANLTIAGAFMERFNYLGSDGIVVWRAWVLFPRNLTVRIVLVLCMIGSTVGILVDAGRGAVRVLGDPAAQGAGQAPGAPVEGLIMSVPLFVTNAIATVLIGYKAHIHRQDMKKNLDSSSSSVIKVQKVLLLLVESGVAYCILWICFTVTTFLNGAVKSIASFEIFGVAMPLLSGLYPIIVILIVTLESKRDLSQLNEMSMSQSIKFAAAPHGPVSANSESFTAVSGSDEQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZF8</accession>
    <name>A0A8H5FZF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZF8"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="146"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="347" mass="38910" checksum="F332B03E52CD4EAF" modified="2022-01-19" version="1">MLISTGMPPLSLFTPIKVGRCSALQHAHQVILAPLTRVISTRQTNIPQNPMMEDYYSQRGNIPGTLLITEATFVAKRVEAGGYENVPGTYSDEQISAWKELWALGRTADVQTLKELDPSFDLVSASDIPLCAKPEPRPRPLTKDEINEFVLYCDVSNKRNDEYGGSVENRCRFALEVIDAVVNAVGEEKTGLRIGPWTTFQGEFPGSKIALSHELTPARRIILTNIGMKDPIPTFSYLISEIKSRYKDFAYIHAIESAVKGDRSKSDPGSEVNQSNDFVRDIWLPRPMISAGNYDRETALKQAERSKATKEGQLIAFGRHFISNPDFPKRFEKKHSHDTIRQIDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G097</accession>
    <name>A0A8H5G097_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G097"/>
    <dbReference type="OrthoDB" id="2734890at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748625" evidence="1">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="197" mass="21563" checksum="B6A35B417C2D3077" modified="2022-01-19" version="1">MKFAISASALATLALAVSSTSAAPAPEFAQLSARQTPEPDCRGAAHGEGIYHNVFDTACVNLIETCRNDLTTANSTDVWSFKRCVAAATCQGTHWLIETLECETGDSIPLTGQNSLDYNIYAGIVGDCAWQEGGCPMTQQNYIDFIFGTLSEINTNTWPDVNNVINNWWSSIKTWTATGETVPYLNFNDWLRFSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2S9</accession>
    <name>A0A8H5G2S9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2S9"/>
    <dbReference type="OrthoDB" id="3063780at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034210244" evidence="2">
        <location>
            <begin position="19"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="508" mass="58852" checksum="57B12A0F72656603" modified="2022-01-19" version="1">MLLFNHIILLFPIDLSRAWKFVSLEMTADAIHREDVTQALVTETLQLLKAEYWQKPILEPAPGSPEDITLKHQEYGADRRETLEWSLAVRILDSICTLMDSGIDGDIFAAALDLHGRITVVLAKNGLPSEEDRTAARMLFRTVAHAKDDVWAIFPFILNRCHRKISKSLSKLRDSLQELDLEELWQVDYQVQSLEDEFPNLVLLKEEGDYTTTELFRIKISRVVELILEQLVGVLDKQNEHTPFILENLHSVLCKIYQLSTTRIVQYEPEPLRRVKLPRRLFKVNRYLFAALTLQAQAHRLWSGGQKIRHRWVMKSIPDPRTRLTKMHLTPSRLLEPWALNITPSVSLKHQSWYPNAWTSWEHCILTRLHPEIRLVIHLDGFEALYNSAPDADFTAATDWRQLIPTSSRLRAIGCSKRVCYACSIWIRAYNSSLKTRWASSETNGRIFVDWALPGNACWYLRLKRVPKAPDDRFLEALEKELATLMSERGFEESRPDSKREVYVMSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2T7</accession>
    <name>A0A8H5G2T7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2T7"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="34455" checksum="372C2C89A944EBEC" modified="2022-01-19" version="1">MSMSCIDQGSFFKAHKDTPRADNMVASLVIVFPTAHEGGSLILRHGGEEFVYDSAKELGSASTPSIGYVAFYSDVEHEVTPVTSGYRVTLTYNLYLEDDTTNATTSPSRQFSLPNSQSFRAAFSTMLSDNTFLPNGGLIGFGLTHQYPVRDRFGDIDYDVFQTVLDTLKGNDLMIYDTCEEFDLNVYLRVIYEDDGGLAMSERIIDENSGDGYEQSFFLSMCGTGTHFGPSATLLRFPKGYNEDDDDIYQRYGIRKPLTEVNWVIEIATYNRLKVEYVAYGNQPSIEYVYGDFSLICEVGPVGNRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3M3</accession>
    <name>A0A8H5G3M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3M3"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5357631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57975" checksum="E0E2C057CAA74227" modified="2022-01-19" version="1">MHQALQLPELVDQILGYLEKVDQKRCVSVCQFWSDIALDYVWSTIAGNEDVLAMARLIAPVWKDFSMDNTSTYRFKSEPTSALWNRFQSKYSWRIRYLWYHYSRKHDVSPLLGAMYRTRPMSLILPNLRVLECTGHFGHASEEAPALLMHNGIHTFTYKVYDDTLSSLRILTEFVKVRMPGLTSLTIEVYGEHDFVEPLAKLLGNLPLLKSIHITAFEDMTPILRRLCHSAVLEKLVFSGGKNVHRVGNLWLDGHFSSLRELHVSQVEGNMTLVPFLPPLHRLQILHLVVAKSTVRNGCGHLIQSISQCSALRELKLEFNHDEFENTTIDDFDVLHSLLACSHITIFRFCSDNPLIMSDSDFTTLALAWPRLEELEILSPYGRDITDNKRTSIWAIFLLTRLCPHLTRLGLCINSAPRDTPPLDPSSLPTSEPAHGANLERLRLGYPLPGLKQGEETVFAELLGQILPAQCSLTYECFDYREEAKWTTIEALFPQFAEQYLATTSMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5W0</accession>
    <name>A0A8H5G5W0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5W0"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="60"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="303" mass="33435" checksum="842BD7FE621FA3A8" modified="2022-01-19" version="1">MVPVTGRYFNQFSDPAQAQRAEIVRKNKRRSAPIIDEHKDEGATPSAIFIPQQLPPLDPAKRPYSPDVKPQIQVVNSDTFLAVRELMNAIGDDAKSGTAVLNLASDEVPGGGYTSLHTAQASHIDVDVEECLCYSSTLYHTLDPLTKHYPWPNKGPDSIKGIYSPGVVIFRGPLHGSSTSEFCPELPSTERKIVSIITVAAPRYPLLTPDRLDFKNPSDKEDLREKVRLILRMAGSNGQKYLVLGALGCGAYRCPPSSVARDMKSVLEEPEFAGWFKRILFAVYSSQSVGHGNFDIFKQVFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G605</accession>
    <name>A0A8H5G605_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G605"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30434" checksum="B1A2F900399751C0" modified="2022-01-19" version="1">MDNSDDETYLLLLLSDSNLPTGSFVASSGLESYITHAFGSKDSYERTVSFMHDSLASYARSALPFVSDAHQLVSQYRNTPASDRSVLSDLHSLDHLYETMTLNHVTRRASKSQGVALLTLYSKGFSRPPSFSSPSADTDRDKVDAKISDLVTQFKLCIRRETTHGHLPVCWGILTAALGLSLERSQYLHIFLQARSLLSASIRLNEVGPYGAQQILLHVSRPLISVQVEKCKDLRTGIISGSSSVDETINGPANTWPLGEILAVRHDLLHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Y6</accession>
    <name>A0A8H5G7Y6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Y6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="108" mass="12373" checksum="EBCEF4D596BBB02A" modified="2022-01-19" version="1">MWNDGPWNKHKARCTKIKKIFKLEHGGDRKQWEAFLRPATPPPETELDRRFIDESKSPPMELLVDSDSDDNDDDGGETRTTQTQTQAQAPPQGPPPPPYRARFMARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G817</accession>
    <name>A0A8H5G817_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication termination factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G817"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34889" checksum="6F3F342A0895E73E" modified="2022-01-19" version="1">MGNDGGSIPDRRDLVRSKPKAEQADKANQTRARWFFCALSKRPLQEPVVSCALGKLYNKDALLEYLLDKSAYGDGKKICGHIRSLKDVKTLKLTPNTAAPPSTSNGDDSTGRAHFICPLNLKEMNGAQPFIYIATCGCVFSHAGFKALAGSSSSGSSSPKDNAKDKDIGEEIKEEEKEQAKDKDSEPQQEQLDLCPQCASKYSKTDDVLFINPSPEQEERMRARMERLRLLEPAKKSKKRKNAGAGAAEDSEPPTKKLAAASSMNPTISAASRAVVSSLAMEEAKRKANMSEAVKSLYGDGKPRREETFMTRGTFTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8D2</accession>
    <name>A0A8H5G8D2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8D2"/>
    <dbReference type="OrthoDB" id="3353107at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="247"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5360176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="71328" checksum="84C707270536F09E" modified="2022-01-19" version="1">MPADTIPSLPASTTHGLLSWPPNVKHAYTALSDIYSAAIQALQSDSETHRMTFHMEALVQDAFPLLLAFDDGIDNYPTLSQWLEQTATMYADLFDDFCAFAERTGGRDSNVSQLHAVNIERSGKRGRPRKVPIYEVLKDAFASHRGISQSEMADVLGIHRNTLSRYLKQYNINSHKFSNISDSDLDTIVRDFRVHHPQAGVRYLRSHLRNNHSLRIQRLRVQESIDRVDPLGQVLRHYTATRRRRYKVSRPNALWHMDGHHKLIKWGIVIHGIIDGFCRTIVGLRASTSNSASTVLDVFIKAVERYDLPSRVRGDRGGENKKVSVYMILRHGLNRASYMWGKSTRNSRIEQLWVEVGVQFARPWRAFFLRLEEKHRLDIQKPAHLWLLHYLFLDEINQDCEQFSQLWNAHPISGEGHNKSPNDMRFLGMYQDGVYDDCEGVDPTVIERFYGADDESDLDTDSDSDTDSDSDADSDNSDSDSDSDSDEEDLEYNYESSDEDEADGDDEYSFRHLEEHVAESIQSQFKHAAISVPKYPDPFSNKQRHDFTALLEAVVGENILPYGYNIRDDEWDEHGYPSVEILRSGRRGSREQRIALPVDDWLPRARLWVQSLVAMNDVLAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAA0</accession>
    <name>A0A8H5GAA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAA0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="116" mass="12799" checksum="5A1D9CDC537E84B5" modified="2022-01-19" version="1">MSTLVFPVVVWLGSYLSAPFRMGVGPFDGMRISLSVFYALTWLLRFPVTHSPCNPIPTNATPPIHILSPELPLSIFQLIIITDKSRPSPTQPPISLNHLVNPNFALYSSVNDGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDG3</accession>
    <name>A0A8H5GDG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDG3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="61" mass="7280" checksum="B298F6EAD7DFAC75" modified="2022-01-19" version="1">MVIFSRLLRRMGAARDTSYRQESESKRLCISHYPVICDFDDSSIYDYRSAIRFQPALLQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDX9</accession>
    <name>A0A8H5GDX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDX9"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="608"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5363163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115863" checksum="9B754F004887C1B8" modified="2022-01-19" version="1">MSTKMNGNPTEKDLTTTLRPRSILERTNSGSIGTARSSASKSAAGGVNASPNDSGSSFSRPSSSLSMRSGYRTGSTLGLKRDSVQAELEENLLQSKRHLNTTLSAASLERELATTKTRLTSCQKTLSEKEAYISQLELDRRHYSDLNATQATVHEEEKRRSDEEVRILQEKVKLFREAKVKEEMEKRDCLEKLEVVERERRNKAGVIESLRKELDAWKNLSRQLENEVEEFRRKEKERQLERQREEEEREFSGHSTSLDASVNANANGTSPGEETVNAQEIYRSELTHQASSLRSLESTITNLRADMAILKSENQTLKERYGDTPGLWNEIGVLREENRSLEVKLKRKEEDVERLIREGERTVLEISTNSLRGSVRGGSIRGSATLGPTHADMSAGMITPAPRRIAPPSTNIASTSKRNIITPTTTRTQPGSLMSRSMKSKKGRSMVETPLKGRGGAGFGFGFGAGSVLNEPREGTRQQRDGEEMTLDELTTSTPRGGGGGAMPASTSALGGVASSIFGSGPGSSSDMAMSRSMASVLEENEQDEVDELQSSGGQDEDVYDRGTSEAPVEDEEVYEDPPSIHTTADLLALRLEHAKLVDEHGETKAALLGMKRKCERLEGEVKELREKVGEDDLIDDDDGKGRSKMREENLGLKMRLRTMEDEVKGAKGELAFVNQVLAQYQADEKAKRTTASSSAPVLDEVTSARLSRLNELEAMYAESKTANSNLRSQLDTLQSKLDKAVAELQRLTQENAHLTKRLSPYESSSSPTLQSLQESLTTETNAKESAQSALAAAEKQVEDHLKKIEDLEQQLFELGGEIAGGRHVPPNVRVLQMADNPADQYFGSIKSVMDALKKQNEGLMKRVEELEQRVKQSGGTVISDTASASAEGAAENAEALVPRSSLDAYITQNEDLTARLERSEKGRQRLLEIFRGKTAEFNACLSVVLGLKTAWSQDGTLRVTSMFDLGTQLIFKPVDRGTWKPGQAKPYVLSAVSENSGLQGLPEMINYWVREQNCVPALVASVTLECYEKMKREGRERGELEMFVTADPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGY9</accession>
    <name>A0A8H5GGY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Alpha-amylase</fullName>
            <ecNumber evidence="4 11">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_005615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 11"/>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGY9"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034849406" description="Alpha-amylase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="14">
        <location>
            <begin position="48"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="13">
        <location>
            <begin position="402"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5364605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="482" mass="51471" checksum="518291F52B868928" modified="2022-01-19" version="1">MLKSLRWVLLLSYVQSCFSAPATAPTGTLHTVHNASAIQARAPSGSKSVIIQMFEWTWDSIAAECTDFVGPAGYGFVQVSPPAEHVSGSQWWTDYQPVSYTINSKRGNRDQFAKMVSTCHDAGVKVLADTLFNHMSGADSGTGVGGSSFTHYDYPGIYQTQDFHHCGLEDGDEIVNYNSREEVQTCELDNLADLATDTDYVRGRLAEYANDLLSLGVDGFRLDAAKHIPTDDIHNILSRLDSTPGYISQEVIFGEGEPVQPSEYVQNGDVQEFRYTSALKDAFSGGGISSLQDLDNRGWVSGDQANVFVTNHDTERNGNSLTQSSSSNTYVTATIFSLAHPYGTPTILSSYTFSSIDDGAPNNGAGTCSGTGGSGGWLCQHRWVAFSGMVGFRNTVGDAALNNWVSPQSQQIAFGRGSAGFVAINNADEDWSATFQTQLGDGTYCDVIASGNCSSSVKVSGGSFDATVPARSALAIHTGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI08</accession>
    <name>A0A8H5GI08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI08"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="222"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="774" mass="86866" checksum="55051E8AE0F4165E" modified="2022-01-19" version="1">MAPLKPTEILEIFNSINDVVPFLAPVKAIVDLMLQALEDVEDNTHQCCYLLQRCVNLLACVNRKCKEGTIREVEHGEHLNNLKRTLNRIRSSVEQISRKGPFHRFFSDMRLQIAFGMRILESVISLAFAIEDHEYARRQDQDRLDHTLVMLQNNDQDILKRLDVTREEIKEATRGLQDTLSRRISLVQKNFAANTLRLLAGRETASSPTQKYEWAISSLEILIEDDVLGAGAFGKVYSGRWNGTKVAVKRLVDGTHREILVNEIEIWRRKQHPHIASFFRACIDSHPPLLVSEYYKFGNVLVYVSNHPDCNRLRLCYQIALGMQFLHNERANVLVDDAHRARITDFGLSRIKTSLTTQTLSDANGLVLPKTPGTKVYMAPERLRQGTNTFSTDVYAWGMSAYQILSDEAPFQYLPEEHLYECVVDRKIRPERPEGDSLVKRGLTDEVWELIGRSWADERSRRPQFKDITVDTQQDMDQSQTTTPAPEDVRLKELLENMGLGNTQTPSTPSQSGYSTLSSGSTPTASEDGIFAIYSPPSPRSPRQDPSGSSSTLDTSSTYTSPIRGNASTQRLYPSQHENSSSSEKVSPRPLKKSRFPSGSAIKKAAAHSIAAVILQVTVIGAGGVGKSTLLTRFSLARFEETYDPTIEEHYRMVISIAGSQLELNLTDTAGQEEYALCSATYYRHTEVALLCYSLTSRSSFETLGRLISEFRRVNAIAPMVFAGLKLDLEREVSRTEGEHVAKTHSSPFFECSSKSGYGVNELLMAVASKAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI34</accession>
    <name>A0A8H5GI34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI34"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22697" checksum="27A873EFE7CB0223" modified="2022-01-19" version="1">MATIPPGLPSKVEETLAISNLVGNVGFSLNIFNIGLKDVNIAHGRVGKADINHGYTSPENPRFILHDSKGFEPGLENTWSTVEGFIRDRCSMERPLKDRALHRDSPHWISSDGMETGDQQLTKLANQCKTKYAFPQSVRTDFVKAQVPVIVVFTKYDLLCNEKSKKRRKDFPSEASEIRKRNADDEAAADLKKRANDYADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ88</accession>
    <name>A0A8H5GJ88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U3-containing 90S pre-ribosomal complex subunit-domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ88"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31622" checksum="71BA9233A813031C" modified="2022-01-19" version="1">MGGDELDNFVLDDYVSASGDEYEEDAEESLLDEAVAGPSTQATTSKADDKKRKRKAKLKTKAKRRRLTESTESENLKSIAEAPPHELADYLASLQAKTFKQLSAIELDELRIPDTAIADTTSWSNPRTLDHLTEFIIKVVPGLHTRLSQKSKNTGSPTLLFVTGAALRVADVTRILKDKKLRGDKGGEVAKLFAKHFKLSEHVSYLKRTKVGAAVGTPGRIGKLLCETDALTISALSHIILDVTYRDAKRRNLLDIPETRDEVFRSVLGAPRVLQAIKAGKIQVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLC3</accession>
    <name>A0A8H5GLC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLC3"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="300" mass="33726" checksum="C9ABECE0DD17DD41" modified="2022-01-19" version="1">MSTDGSKEKPTKQITLDLGELDENELAFLKSQTGIEDVEVLTRHVEDIARRAHKVFGYDYLTRTLFLKFRSTRLPVYKHVLELGKTRDDALFLDVGCGWIPQVGHDIRKTIADEYPIQNMVGSDLHPEFWDLGHELFKSTPETFPVPFIPGDALDDDFIPNRDPFLDMPTTSKPSRQSLASSKSLASLQGHVSVIHASALFHLFLKESQRRLARKLASLLSPVPGSVIFGVHRGLPQPGEIFNTRSEQIFCHSADSWKRLWIGGEGEVGVFPSDAVDVQAVVIQVALKETWILVWSVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLM2</accession>
    <name>A0A8H5GLM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLM2"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
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        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50076"/>
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            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF5367046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62242" checksum="D01843429950D596" modified="2022-01-19" version="1">MGAGASTAANQDTSAAPDYYTLLEVEENASSDEIKRSFRRLALIHHPDKNVDDPEGATKRFAALQQAYEVLSDDQERAWYDSHRASLVPEPDEKSVYEDIRKGAPPPRTRGRGLTARHLARFFDQTVWTGFSDEGDGFYAIYRNLFARLQAEEELVSDGSYPSFGYSTWSWAPAHKGEEATAARTFYNTWMNFATSKDFAWMDQWNPAEGPDRRVRRLMEKDNKKVREDARRDYNDTVRSLAKFIRKRDPRYKTHLARQAESQNQVSGTSTPSQRKTGHVQDLAAKYVEQDWQKLDTRGDDDLEWAAAEGEDPEEWECVACGKSFRSEAAWDSHERSKKHMKEVERLRREMQDENFELGLGDGETQSEPDDDPGLQTSADIAPDGDALPDDTFPRTPLATDTIDNGHVQSKKSRKKKASKSLEPIGRPTKTEKMMRDVGELDRVSGTVGDDQDQTTGGRYDNELESRDRSGGAGDVVSEGPEQLSKKEIRRAKQAKKMETKASETFRCNVCKAEFPSKTKLFTHIKEEDHALTDETTNGASGRGKKGKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLT7</accession>
    <name>A0A8H5GLT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF56">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="177"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32569" checksum="0D133F81C69B2DA0" modified="2022-01-19" version="1">MSGFDKPDAFVDSQDPEIVREAKKGVVEDTYSFTERDIILYNLGIGATAEQLQWTYEGDDDFQALPTFGVIPQFHASGGISLDWLPDFNPAKLLHGEQYLSIKAPIPTSGVLVSKARILEALDKGKAAAITSIIETREKSTGKLIFENQSTVFIRGSGGFGGKRSGIDRGAASAANSVPKRAPDAIVEEKTTPSQAALYRLSGDGNPLHILPEFAAIGGFEKPILHGLCSMGIAGKAVYQTYGAYKDIKVRFADVVYPGETLITEMWKEGSRVIFSVKVKERNVNVLASAAVTLVDGAAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMV7</accession>
    <name>A0A8H5GMV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1642"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1734"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1793"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1870"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1250"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1404"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1475"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1548"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1586"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1671"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1818"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1828"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1870"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1923"/>
            <end position="1940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1940" mass="208448" checksum="3EA4A7894E44C056" modified="2022-01-19" version="1">MNTEDYDYDDVRRNAALGLLGLSPTNLHPPSTPLNLSGFPMDSGSLSSSTPNHLASNRSPSISSLTAPRRRTPIESQHTPSMSAGASSRSVSGSGRTAEEEAFGGQATSPIIPLKRKHLSNSNETSSSQLPNNASSSSQSQSRRRGAGGGRGSNGRGRGGRGSGANAGAGVRHTSDGQHSNSGPGSVSSTRFDPVAHARRTNDRDAASRDIDSLSITTHTATPDRDQEMPAAGGGSQHDRGVDHNADSDVDPESNESIRCICGVSNDDGWSIGCDGCGRWCHGICFGIDEKDKENLPERWECWVCDPTLVVDRERAVRLQKAKSLSGGTGKVNSNGDGDADVDRANSRRRTSPGVERKPRKSSAGMTTVENGHKRRRRSSIMTSPVDRLHALPSSHHSDHPPHSANGLITPGNVTVVNGTSGAGEDTIVDIDEPWTHAYNDITHDIVPQTETWDKLRRHAGSWRGVTAISPVTDSQVPDTPSQIDYFQQHPYIATGQQYPPANTPVAVHPLHPILNPNQPTPSNLPPHLLRPPTYALHATSPIPCSSLITPFPSTITSSATYLADPLNAYAHLGMPKPYVHLIGPPLDVALDARVAGGKGRWARSGCRPNAVLRPVVCDVPDAEKSKRKGKEDRDRVDGKERAKGRKGKNDATNSETDLQTLAFGIFALRDLKADEEVVLGWEWDDGNVIHQLPALLKEEGTFPPADLHQFRIQMSNILHTLTSTYTTCACGARSSDCAIKRMAEFVERGERLEQEAMQREKELLERELKDADRRRREKDEMARQQSPWTPGIPQTSFSAMPTPRLPWDAFLGPARPSSAPQASTPTAAGHGTFTLPHERRQNVAVPQNDQETKEHRPIDLGPLVGTSRGFKTRERVPGSGGLSGVEMDTSSQQHESVAGPSSLRVNTELNGTRPRSVPAVPSGMPTHQFLLSPPTPNPNHGHVILHGHERAQSSHLAEVPLPRLGYGIKKRGNIWGDGKGKGKAVEFEEPEMEVDVEGEDVDMDALDGDHKGSTSHPRSRKPLSRNKAKEKDNFQSLSPISLSTSLHPPDPGTPRHEFESPSSPIPEEKMPPKMRKRWIHKEAEALLGASKNVLKPASTSNHEKGASEAKKKGKDSAVVESSSEAMDVDEEPGARDGGGDQHSETDSRPRASPSDPFARLSLGSPAIPPSSSSSKSHPIPSVTLPHAEPSQRDSHPQNLSSVSSKSPAAPPIRTSSSFLARVLNSPEHSWTPFSWEQSKPETSNNESARSPKVDKALNSEIRQSDNEDHAMNDACVSKEIKKEALEGMENQSHSTDGEDVVMDESEQDELLPTPSPPHSPSRMIDDEPKEREDVEVDSEDRRSDSVSSQTSTLRQSVPPVIEVEPQSTVAAAEIQEQSGPDTEVNASPALTTKSLHPLPLPSPAQQSMPLSSPLSSPISSPIEPTITIDVQPPDNGIPTEQRGSASSDVVPELVPSTSISPDQSVRDVPPATPPSILSSLSPFSSPVSVNGRDDDVKSIRGSPIQGDSDTALESKTEPPREPSPLPEPEVMKDPSETAGDVAMPSQEAPSTPLITSSNANTETTVEVAPCTETPTQPAPSKVKLSLKDFALRKKRMREEEEKERAEKAKAEAAAPVEETPPPAVQVEPEVAVVNGEVDKIEPGKQDVLMESEQDVEQSKLLTSTEPPKGPVEDVTVKVEEGSLKSDPVTAPVPTTVNGDAKGRPHSPSLAPLPMNILSSLPALTLTPVVSNPVMGSPAPDILNASLSRKAAQQEEGEIDDVPTPPMTSLPRANPLPLKPSTLIVSKHTSLPSNPVLQHLPQNPAKPSLPSFRSALKHGPDSTDTRSRTPPTQPRSFTGYGSQYTARSPHAHTSPIPTTPRVLASVATAPTITPNPSSTANPIGATPLSAIGRPPPSGPRALRQQQQNAGAGRPPIHSIPRGPSHERDRDTRDWPHRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPC9</accession>
    <name>A0A8H5GPC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPC9"/>
    <dbReference type="OrthoDB" id="3038119at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="286" mass="32450" checksum="02A3A83C96A0EBAF" modified="2022-01-19" version="1">MNSENDSDLHKTISQRIRSNQRKRNPSTNENTKAVTVNVVDDDGPPESRRAKNRRVNPEKLAERLGPDLVREMEVYIQSGAMMPNFAIRKELQERYQVDRRHLYDYFHARGLRVAKEDRHCNLARSRQAKAKAKAVKEASRTSSVTPSPLPPSSASQLPKKQDEIPSPQAHISTPSANTSSMDTCNKEDQSFAFKTPYFSGESMSLPHGQLPVFPAMGEFQNHNVYPYSFGQVYDGYLQPTTSYHEMSLAHNPFPLGYSDMDIDPARSFLAGTELNFDIYYWSEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ40</accession>
    <name>A0A8H5GQ40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ40"/>
    <dbReference type="OrthoDB" id="3541472at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="420" mass="47338" checksum="46F4942F84BC8390" modified="2022-01-19" version="1">MARPFYLHPGKVYPFLSTRQIRHQAPPQILQKFSVKLSSSNEPVSSPWRTSTSPESNKLFEKWDEGSYLPLYTVARTDILYSTKIALKGAYKAPEKALSYVVVAGLQYRAFFLAGEFVARDVDPPSLHLDCLRNLCTLAIDGTRRPESAFGQTILGPLSTALRNSPDLQTLDVRVPFSWSMSFSFSDVLRSILDTNGASVLNIKKLVVEDLAMDDPAAMVLHLQYPSSLEVHIGGWNTEVGNFWNVLQTASVSLEVLKVYCDIDRTLLDYISHCHSRLKVLHLYGAAGKATDEMSDELADLFFGSVLLEFTQSLRELKICPSYEGRWCLGPHNVDMFFRCSNLETLSDDIVNRAHSFPKLKSLDFSTTDAMCGRGARSLSGRVEYAREMRSAIPRRHQESAAYRSSSWFWTVHLRIHIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQD2</accession>
    <name>A0A8H5GQD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQD2"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="305"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="554" mass="61371" checksum="D03C98261A13DEFD" modified="2022-01-19" version="1">MADNRQRLPQVGVAPARRTRKPRISSLNHGVSYASTSPQTLTKPSVTRRASISGLTPSIAPKAQRTSKTSQKLVVLPSAPQTKALHDEEEALTLGYETDAGVHVREYKSEAERMSKEQRKKAGFKRITAYCIAESFKMKLLAGFLKREHNVAPRVFDEALYAMYHLPLLPGYGANVNIRSSAPVQHDDGKSILARLSEAEEIGYQGSYFNHNPERLRDDGYITSSPTERRGGVRDSGLRSAVSGSAPTVSDSEAYTDAENPNSPFSESEQTTPFLAPEVSLVSPRAIADPAPSAMSNSEPENAEVIFFDYGVVVFFGLNEAQEKDIRGLLEIEECHYTHDPNIAAPRIYNDFFTLKSRSHLLKLSISHALAQSTLLAHFETSTQLVLSSPETLSIPQQLAKKGALQMKRREALKLTGKLFKLRRDINLVSNVLDVPELFWDEASLKELYDAVREYMEIGGRVQVLNEKLAVASDFLEAIHDHLNNSAMERITWIVIWLIVVAILVELGEVIARLIVHATMGGSEEAVRQAASSIPLSREDALRTLDRMVSQPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRE5</accession>
    <name>A0A8H5GRE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRE5"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5369747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1063" mass="114906" checksum="1EC13C69B9D0C630" modified="2022-01-19" version="1">MSHIASSSSPIKRPSYASRQSYHRYPSAMSKLGDRVSVIHISNLHCSSCVKTIEDTLSCLKPAPHATEVSIVLQSVKIYHSAALSLDTIRDAILDAGFDVVSDSESDSSIMSHAASLHLQQCTLCQQGLGGRPSEDSSFSHESSDKKPTPFILSLSVGGMTCSACSNSVMNALNNIPGVSRVAVSVLDNSACAIIEHEDLVSQITEAVEDCGFEASVIEIKPLYTDVETSENLRNVSLRVSGMFCRHCPDKVLSSLKQFESRINITKPLHYPEDSIFTLTYQPDPPSFTIRNILHAIRSGCPELQVEIYHPPSLEERSRKIQLREQRDYLFRLAFTFIVAIPTFIIGIVYMSLVPDGNPTKAYLMQPMWAGNVSRTQWALLFLATPVMFYSASVFHRRSIKEIHALWRKGSTVPIFKRFTRFGSMNLLISAGVSVAYFSSVALLGLAAAETPSVNGMGDVLTYFDSVVLLTMFLLAGRFLESYSKARTADAISALASLRPAEALLYAPSSRQTSFDVPTNSEKDTEKADPESESAALSSASGWTVEKIPVELLEVGDIVRVQHGSTPPADGTIVSGEHGLFDESSLTGESRPVKKDSGDKVFLGTINRGEVVHIRINEIGGHTMLDNIMKIVREGQMRRAPMERIADVVTGYFVPVVTLLAISTWVIWLSLGLTGSLPADYLDSSVGGWPVWSLEFAIAVFVIACPCGIGLAAPTALLVGSGLAAKFGILVRGGGEAFQEASQLDLVVFDKTGTLTAGELRVAESEFVIGRLDKQAILGMVNEMEGTSSHPLASAIRKYCIDNSARVTKGSSFEEVAGRGLKAEFPDWSCTMIIGNEVWMQENGVRVSGLMANRADEWKSRAMSVIFVATKIENGKFDVVVAFAVADVIRPESTAVVSWLKKQGIDVWMISGDAQQTALAVARAVGIPSSNVIAGVMPQEKAQKVEQLQSLKRGRKHDRTVVAMVGDGVNDAPALTVADVGIAIGSGSDVAISSASFILLSSELSSLMTLIDLSKTVIRRVRFNFIWAAMYNTAALPIAAGVIYPAGHTRLDPVWASLAMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTV4</accession>
    <name>A0A8H5GTV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTV4"/>
    <dbReference type="OrthoDB" id="3026831at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61526" checksum="D9BDE50466D8A4B5" modified="2022-01-19" version="1">MAESSEPNAASFFQHSHQISVVNSTFNMVAGDMDVAHNYSDQGSGHRRSSLLSQLLSRIGEFIPWSTESPTIVSQNNIELLDQLSSRRHYRIHSGKYEQRFVLVKVFQGTQAEKAVSSFASGRPFIVYNFAPSRGSVGSWLASVLAKDLSDILPLSCKIVSELAFGLDYLSSEGVQAGSNDDNNIEIFITDQDMLKIAPDFGPLRNSNTRCSSGQIDDSLWILFNKLCAKAMRQTFSEATYILHQDHRSRDTLARIDEVSATDTDTEVGDTQNLIHDNISTSNSSEPSVIYRRELLWRGSKHGSQSVAAIARRYRQLWEHLNLTVGQSYPSYGMPRKQAARPLRTIVHRCQGYRKEEITLTSDVSDNAIVSHFIPSLYERCLVCKEVVKEEEFRCACDGIGSADDGISPTIKCSVCRVWQHWSCIVVPRDNAQFICSSCGTTPAPENLSSNLHDYSDQQMQIEPDTKRSRMDSASSTPGRRIPIPSTPLSPISPVRPSLTDPSPISSMPPPISLMHPLTIPFRTQASQSPRPGQMNANAVNPHPNSNLNPNPAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVN4</accession>
    <name>A0A8H5GVN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVN4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="487" mass="54755" checksum="6D2D6BD27308F369" modified="2022-01-19" version="1">MHTFPENNKIATSHTKTEQAVGIEPVSLFESLPSEPTVENPNPVTTPSPTPSHEHSPEPHSPHNRSPTDSTPSAAQEPISINPTLPIDFHSIHAALRMSENPASATAATGGTQAPRDAAPPDDEAQDAQSSVFPNMTTKERGVKPEKFTGDWNQTKDWMAEFNNYLRLNDQVYPTEDEKISFFLTLFSGDEAKRWARSMMKKVFEEEDDFSDSDEEYTSTDEDSSASKPKTKKLWTLHEVKREFLRDFKPAARETLAQTKIEHIKMEGALADIDKYNSQFKRYADDTGYNDKALMKWYRKGLPQGLVDRISYLSTQPRNLAALQKAAVKQHMIWLERQEEKNSWSKPRREEGQSGRGSQSTRSGRTRSIEVNALQDNVPGASSITKYPPKLTPQEREKMRREGRCFRCHGLGHMGNDCPTFPSTPPITPNNTTWRPSIKKTAIATEASEPRTNATTDNISELTTRIGALSGEEKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVS6</accession>
    <name>A0A8H5GVS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVS6"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="164" mass="18362" checksum="B2364208B5187277" modified="2022-01-19" version="1">MSGKPTQIARMTELFPAPSPPPSTACPSRWPGANQESTLALRDILQVNHDKYHVFFDDRGRHNHISHHLVVLWSMGSPKAVLEAVNEESRQIQRPRGTAPEPITRDNLYDHVGDHKYYAGYLEYYEGVVCEKGAAAALQEYIFSPQANFSGIRSGQTENPQMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVY3</accession>
    <name>A0A8H5GVY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVY3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="15382" checksum="FD21E4CA5552A46E" modified="2022-01-19" version="1">MDTAPDNASVSGNANSVQQQPKRSAGQTVCLALDSCAAKIALTGGTSYAFGSTWSRLRPSQFVFDNPPPQALVGSSLSQPSGNAQRVRELFQKSRLNVFRNANQVGMIFASGAAFAIILFIPDMTDWVRILCIVLELWFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW05</accession>
    <name>A0A8H5GW05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW05"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="499" mass="53624" checksum="9FEDB5F682B49013" modified="2022-01-19" version="1">MRKRTPWGSSTGSIVFTRVLYVLTSVLLPTLTVRSLNVDTLPSEVALGEDITVTWHRTTTAHADPTQWEIEFVQDDNPLPDSVFIVPAQAAGDGTVEVTIPTSVPDSGKPLQLVAFLPERNAIFSTLAQFSIQGGQSSSQGDPDKGMSSQDTTPTTQTSQSIRQSQASDQVAGPLTSTPTSTLTTGSKASVSTNPSTSDSISQTTNTASSNSSSSSDHEDASGAPSVFGSTDTPSLHGTTPGSSSSTSFNSHTTDTSSSNLPFNGGSSGASAHESRLAIILPSVIGALVLLLVIIGIFWRCRRRRTQRSTRKISAPTDSSNGSNTSSDTFHPYDLKPEFPINPPDRLHEPFPGEAESTCTDNSNIIPLTRRILRGWHGTRDCSTQPHPYQLKQEEPTVNTATQPLTDNHRASNNGDSSLSYPSTNVRPRSLSESSIARSPIQGEVDLIPAGRSVFARDRDTEVHDEMRQMREHIQRLEMLVTSNGTRGLTDEPPPMYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXJ6</accession>
    <name>A0A8H5GXJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 88 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXJ6"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034149547" description="Glycoside hydrolase family 88 protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43868" checksum="C4B6F0F8E6491D4E" modified="2022-01-19" version="1">MLFPILLLALSPVQASTVPSNLFSPLISSKILKTSNTLPSPIKYNQFTTTSGNWLFFVPDTWTSGFFPSTPYALDARAKLCPDQADSTNWVDLGRSLSTGLIPLEHSNTQGHDVGFLSMPFQWELLVNPQNETAIQAVNAFATDLAARYNPVVGCTRSWDTADPTDFTVIIDNMMNLQVLFSSYNLTGNTTLLSIALTHARTTIANHIRTDNSTWHVIEYNSTIGSVIRKRTAQGYADNSTWSRGQAWGIYGFANVYKQVLGTDNEDEVFLDTARGLASYFLDHMPGDGIVPWDFNAPAEGTGSPLAGVVPADSSAATIAANGLLLLAQVETNDDLKQKWIDGAINILDKITTLAWKPSWQSLLSNGTVNRPANNFATGIVYGDYYYITAGNMLVEMGLAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY22</accession>
    <name>A0A8H5GY22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY22"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="179"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5373181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="39586" checksum="E0A901DEBC150185" modified="2022-01-19" version="1">MSASSGITVSPELTSTFSEAVESQQTRFLKISILNESLVHDLSVPLQGTLESDFANLREILEDNVPAYVLAKTDSPNQWTAIYYVPDTAKVREKMLYASTRSSLLKSLGSTLFNDSIFATSKDDLTPEAYKAHLAHLAAPKPLSAREKELEDIKAAERESGTSTPYEGARKMASPLVTGHGLNWSEEVEQAVKALGEDEEEKILVIMIDVKTETLKLSNTITGGASSLKTALPSSEPCYAFFAWNHSYSNSPKRELVFIYSCPSTSPVKHRMIYSSGSAAVAHGLKTILSSSSSSISVASRRIETSDPSEVDEEFIKDGLGYDGVGGGSQEQAGSTVISSVEGRAPLPSEDRKAFAKPRGPARRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ82</accession>
    <name>A0A8H5GZ82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ82"/>
    <dbReference type="OrthoDB" id="2906386at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="413" mass="46908" checksum="967AECA63A353FCF" modified="2022-01-19" version="1">MLKRKYTAADLEDLPRAELVKIVKAQKQLWPHFDRHRPSAAKIKERILADDSPFLKDATPVPDSNRSLSGSQLSSLSQTPERELTQAIQGKRVETPGDLSGIEESHSIELEEIKVYIYNMADSSTLRQRVRVPIQKEGGDGEKELRVDSLEVLNALQNTTAKFFGNVRFMVLVSDNKNPFGGELYEFFAVLEASEFKLAIGSDTYLRLDSEYQLAIKVEALDVSAGELTSSEPKALFDEDYHASGMKPLEYARKIAPERKRQRIESKNEKDQQLLTWLREEIKRRDGYEEFAAAKELANSRKLQNPDIEDYWTFGATCVEDLAKTTCASVDNWKVNKWHIHEALDLPASWFTAARKGVELISIYGPNGPFKASKVVSELERRSDKPGGWTGLLKFLKNHHKKAKKARQKKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H060</accession>
    <name>A0A8H5H060_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H060"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="14111" checksum="6052C63A7B85B0F3" modified="2022-01-19" version="1">MSQLFMIANNQSIIYDIDTGLETPLPDIPNGVRVTNPFDGTAALLPLHPPYYIPRILVCGGTKTSTDGLRGPLGSRSYNLTFLRVAMLDNSTGPRCHLITVTGHRPLPQRRVICNAHHLSPLLIAAHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0E4</accession>
    <name>A0A8H5H0E4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0E4"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="148" mass="16850" checksum="37E9FE77C3F1E299" modified="2022-01-19" version="1">MLLKLLLHVLLHRHRRQIQGICSGREMDRRYEVLEVFEGKEVQKVNGTLMDNEKWTVEFGVEEILRTFDFEVDKYHPQFYHKTDKAVPSTLNASASLTSNPHTPAQPKTANSNALSTNTKPSSPPVSPSPLPTYHLRPLQCLSLHSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0S3</accession>
    <name>A0A8H5H0S3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_000054</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0S3"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="19">
        <location>
            <begin position="340"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="1043"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="1073"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5374866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1146" mass="126543" checksum="E0210C3F8DA48A75" modified="2022-01-19" version="1">MSDQVFSVYSRDTIPASAPESPSDTEKLFLEFLTQYRVGGEFIYRDKLRANLLLKQHLLEVDLRHLSLYNDELAHALQDKPAEVLPLFENAAARLARSILFPRTNATNPSEADKTAAAEAVNRIQITLKTSLNMLQFRNLTADTMNKLVRIPGIVISSSVLSSRATKLHLECRSCRHIKILFPQGGLGGMGSGSDRGLPRRCEGPAPTDGSKKDCPLDPYLIVHTKSTFADQQTLKLQEAPDMVPVGELPRHMLLSADRYLAGQVVPGSRVIATGIYSTFQGAKGRGDAAAATHRPYLRVLHLEFSSPAGVGSGGGNPFGVAFTPEEEEEFGEMARSDGFYERFAKSVGPSIYGSLGSDNREDIKKAIACLLFGGSKKVLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVQRDAVSREFYLEGGAMVLADTGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPVFGRYDEGRSPGENIDFQTTILSRFDMIFIVRDEHSENRDKLIAKHVINIHMNRPNDNAEQNDDELPLDKMKRYIAYCKSKCAPRLSPDAQEMLSSHFVSLRKQVQQVEQDNDERSSIPITIRQLEAIIRISESLAKMTLSPAVLNHHVEEAIRLFKFSTMDAVSAGSADGLSRGELSEEMTQIEKELRRRLPVGWSTSYQSLTKEFVTQRGYSQHALERTLFILEKKEVIRFSGQRRGLDSELLCAAEALTEGKPERRWVSAQAPRTRTSSQLMVAKAMVPSAPYPAGSTAYDHYNNAEYAKQQQQYQQQAFDFLPYHANTDVLAPHPDLFDSELDSSLAGFDELQFQLLTVENNDAFAFLRSDTPTCGPPSTITVSSESASAYDSYSTHSESLYNYPQSPYAASNYSFPLDLEMDFQRIRVDPVADYANNQAAVNGMENVDPSTFGSLPPTPPRSPPNHAQAGVKAYVGRSSYSDYGPATRNTVTSDYYSQVGYNGSHVNPSSVSPVHVNAQLPLVPSIPLVASPEEFKGDPRKKYKCTICPRAFARAYNLKTHMATHDPNRLKPHVCPHRSCGRSFSRKHDLGRHLISIHRDESVCSSQHSKTSHKSIGVEKGPRSWCERCGKSFVGRNTDCDCNDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H148</accession>
    <name>A0A8H5H148_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H148"/>
    <dbReference type="OrthoDB" id="2634326at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="71" mass="8185" checksum="EAFAD10AED8F891C" modified="2022-01-19" version="1">MTAELSPQDLLRNKDSTRTITFGDGLAGALHRRTQEFITNPNRRVVYQPPFGSTRDLYRRSDTRYGEDDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H2L3</accession>
    <name>A0A8H5H2L3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H2L3"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5375270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64160" checksum="6F30ED873995022F" modified="2022-01-19" version="1">MPARRHKSKSKSPNPSAHANSLSKQGMHKSDDSMAVSSSLNTLLPNHSPITARSQSRMHLENGENDLELNLLAEDERRQARQGVEGYGPEPAHDATKRPISTKDKKAMVLLCVLYLIQGVPLGLALGSVPFILKDHLSYSQLATFALSSYPYSLKLLWSPIVDSVFLPSIGRRKSWIIPMQLVVGTLMLYISLNVQRLLDHPGDYVYELTFVFTSLVFISATQDIAVDGWALTLLSHDNLSYASTCQTIGLNTGYFASFTVFLAFNSVEFTEKWGVPHLTLSAYLKFWSGVCYLVTFWLLFFKKEDKEPATDADMSIMGVYKTIWSICKLKHIQSLVIMHLFAKLGFAANDAASSLKMVEKGFKREDLALAVLIDFPFQILGGYFAANWSRGDRPLRPWVIAFWPRLAFALMATLIVYWFPTPPISSGFFVFLIVHTVLSSFSSTVQFVGISAFHTRVSDPLIGGTYMTLLNTFTNLGGTWPKWFILKGVDAFSVATCKAMEAGIEISIKANECVSDYGKSMCREIGGECVTETDGYYLISAACMTFGVAFLIFYIIPTARKLQELPASVWRVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGM8</accession>
    <name>A0A8H5LGM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_008277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGM8"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="482"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5356542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="68591" checksum="7CCEF0063DDEA98A" modified="2022-01-19" version="1">MASSLPKLPEVPGTDPLSCIFDAFRTAIAKKVSDALPELTLEQVYSGVDYGKKGVDFTIALPRFRLKEKVDVLAKKVIDPFQADDFVESVTHDKAFLHFQLNTKSMIREILTQVTSQTRLGASEEQKADKNYSGTYGTNTSGEGKTCVIEYSSPNIAKDFHVGHLRSTIIGAFLANVYKACGWKVVSMNYLGDWGTQFGLIAVGFERYGSQEALEKDPIKHLFEIYVKINKDAAEDPEVKVEAAKFFKRMEDGDEEALKNWRSWRELSVKKYETEYDRLNVHFDMYNGESMVGQEWMDKAVERLNEMKLIDEVDGARLVNLEKWKMGKAVVRKKDGTSIYLTRDIGGAIERYEKYKFDRMIYVISSQQDLHVSQFFKVLELMEFPWAKDCVHVNYGLVQGMSTRKGTVVFLDQIIREAASVMHEQMQKNEDKYNAVEDPEYTSLELGITGVKIQDMAAKRINNYNFNWDRMLSFEGDTGPYLQYAHVRLASIGRKNPHLLPLPSPSQIDITTLTESAHAREIAFLLGSYPDVVKTALKTHEPSGVVTFAFRLSHAISSAWETVVVKGEEDEEKARGRMWLYESAREVLAAAMRLLSLRPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHR9</accession>
    <name>A0A8H5LHR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHR9"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="276" mass="31643" checksum="623EBC0CE9A2E39C" modified="2022-01-19" version="1">MSWLNTAATGKEPEPYVEPPSEPKVKDPSIPNRMVSDKPANRPFLAHRAYREKQKKLHEEWLERKKIRDEKIARGEEVGPEEKDPTAQEEVGVFGILKFFVYLIIFTAVAGKFITGSYTWDYEGKWVQLKTYLPDRNQRLFSERLLSEFDGSKEGRPIYLAIDGDVYDVTKGRAYQPGGSYHILTGVDAARAFATGCFKDHRTHDLRGLSNKELDSIKHWKTFYAEHKDYFRIGRVSHPPIDPASPIPEHCDPKKAAKQEQAEKAPKKKAKERGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK19</accession>
    <name>A0A8H5LK19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK19"/>
    <dbReference type="OrthoDB" id="2355984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="21776" checksum="C3A378D9DE42ADFF" modified="2022-01-19" version="1">MYSNTYVEDRTETLANGVQLSFGCQTPSKMITDANEWGVAWNMVSATYVCAYPHLEPDIRAYRAHMQREFASVRKAFYSQVINYDKAVRARIAGVRTIHFSEFHLFSDLRNSHINDTGSCIDVASLTPSSASHTVVTKSSVPCNNWNVGRCTSTPGKCPRLHICNPCETPGHRSSKCPHVPSKPDTVTSPSIPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMU8</accession>
    <name>A0A8H5LMU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMU8"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60188" checksum="9C8116196988340D" modified="2022-01-19" version="1">MVGHTSADFVISGPCEIIFVQTNGHRYLLCSVSVLESECYKYIGLPCTDYQPPLLPMVSLFTRGSFVYFNDPQSQNAGKRTIIVKPSSKLNLPTPDPISLNPLDLIMPPLFLRFVMMYKLRHDTDAGGDPKQTFDKVVQLLISSLADALELYPPGAGRLRPINPEKGSELAIFCDGTGAEVVVHRENRPFVEAEHDLQSLSPGPLFLPLDEVAKKGSLMVKVTKFSCGTVTIVPQLHHYVADLGAYMDFVSTWAKIANGESIDMTLFPKSWAHEPMKYFSSKQIDPSLVPTSVPGIVVGPEGPPPLPFPKIRDTLRWYFSDIALEQLKVDCTSLLNLNPSNNTSSAAWISTADAFTALVWAAQTRARYAVDPNLVADETQTLGVAVDARERLKALGLPHHYFGNFNLSLAVSASRKDLLDTSLEATTRVALAIRTGLLEHLTFDAMAYRMAFLEAQALALEGQVGHRLMLEGDNRSTNWSKYDLTKMLFGPGLEPVYTNVGTKINFPAGSVVIWKAKGGVIVASPVESKEADDTLLADKLMVKYGAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPB9</accession>
    <name>A0A8H5LPB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPB9"/>
    <dbReference type="OrthoDB" id="3234968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034503529" evidence="3">
        <location>
            <begin position="25"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="443" mass="49225" checksum="412E0CEC89DE7F8D" modified="2022-01-19" version="1">MILRAELSLIALCFLVLRLTYVSGQLVNNTLEESDARIKYAPEDSEPGWDKINHTNTRFSGGIIDSVYRDLLRTHAIHETSPGVAIYYYAALWPWNISTILTLDSGPDELVDLRDKSDANSLHAVHQEKATQSFDVRWWREGLENEEHTLVVSMGDSTLAQWVIVDRLAFTSVNSTSTSPNRSKSKIPLIAGLIGGLLGGFFLIAVIGILLLRKRNGLRSFASNGGRQVTITPFLQMQSSSAVAAKGTEAAREETSQNQCSDDLMRPPPSYESCVIIVRKKRCPFQCTRLSTSSSFAVTTSVWSTVLGYLVKYEGDDSGSTTPSQPTLTEQLSHLLRPSKNPDSTKNINRRAKILKNVLGQERERERIDGERKREREREKRMKLISKEGSESDVGTSASVDEKDPDPIDISTHISRLRLNLATSSKALLLHYPTSGSLTKVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPQ7</accession>
    <name>A0A8H5LPQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPQ7"/>
    <dbReference type="OrthoDB" id="3064136at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="473" mass="49721" checksum="FA3673983307D366" modified="2022-01-19" version="1">MDSGIPKDARDTVTRRQRHKDGKLLRGGLGLTTGLGWSDSEASRRISKATSKSKSYGNLRQASSVSSLRSRPATARSSTYSSQSHGSSKLSRSYSSRTLGDFDEDEEVDEFGYIRDGKSGNDVKGKEKLPPTSWQGKSFGLLKNGERMRTASESSASVPYVTGVQPRSLTMPQSLSREEIETPSTASSVSIPLPVTPDAYDFDENGRSAKTPTIGDTLSKTTIGEVAYQRLVVDKDKMLPPLPNPRTGSIRRPQAGALAARRQASAAARGATLSIATAEGISLAPSYHETTAVSNSTSTTSNSNSTTVTASSIPTPRRSGSRSSSLRSSSSSASLRNAPASQAHSQSQIPPVPTLPNQPLRQLQLPRYSANHASSGSINTHKQTAVPVPSTTRSISGNVASPTSPPRKPTLSGSISVGSLRSPQGVRTAPSTPVTPSTPGRPRTGTGMTYRRSGSVNGLSALKLPSSRSTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPW8</accession>
    <name>A0A8H5LPW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPW8"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1102" mass="122996" checksum="CA731AF4E08A855F" modified="2022-01-19" version="1">MSKTQAEVRQDRSLLKVGKQRVSPHRYRLTIFPSCKRRGCSAICPNGSLITGQGTRFVLADTEKLHEKIAQMSDRIRQLEDALTISHTTSGTGEPHPLLGRDLLKIKSSIELHAAIQGDDAGIKQEDQEDTAYLDTFGTLAIRDDGAATFYGRSAGSEGEASTKSPEQNGSHGSPNPNASPIIGLDIISSSSQSWSQNGSHTTGLPPELLAVSQSFPLPIGQANIDLDYILENFLPSQDEARRLCDLYLEQAPWFFGAVTKRQLHEEIIPLWYKEAPQPSTIGNGSPSDYDHPMSPPTAVPESGSTSSPVVSSDSSNILQKTGGPHDLALLYIIFTFGALTDMNLPAAPDNTLANHYYDLTKAALNLEGVLDRPPSVATVQVLALMGIYEGLRNGENSIESTWALMGMSTKLAQSLGLHRDCARWKLSPSEVQKRRALFWELFITDCWQSLATGRLATFSLPFVDCELPFDPDQTLSADGAVQPSFPYWKARFGAECVAPVVQCTLTSRAPKYSIILELDRKVRDMELPRYCQEPPPENAGLGETMSHYMPMNYKELTLLYIHRCFFTHAIQSNPADPIKSQYAPSFLAGYRSACDLLGLVRKQFNAFPAQIARFWVLWTHAFSSSVMISSVVTHGSRSKVAPAALLELKSSCDLFEKAAAYGGRAVKFLPIIRRLLAKAQKVFFDTSSGVPPVVPNDIFKPSGTEEDDEMSIFGGKTHVVTTKAARPATARSPASSSSARSSQSPSGSPQTTYTTTNPLFAGVHPGLISEYNTFEGHISARLQSAYNADSSSFNETLMSPRLHHAQSVQQQEQQRQQQHQQEAEQRRQREMEHQRRQQELLEEQRRQQEEEEKQQILAQEQAYAEAQRQQQLQQQQQQQQQISYESHYGGSQEHLPSQGLPGAMPVQERPKHTLAHSRSRSNLHRMDYQEYHQDGRYQYDQQQASHAHMHSHPHSHPHTQSPPHRSHSQSSHSQPQHEMYAIPPEYMQHQPSPSSPDVISPISPTHPHSFNSPETLLDPHSHPHAQSYWTHHQSPTNGVMYQEQHHHSVPVPMQPRHPPQPQHYTPDAAMRGMAADDPRLQETWQSYMYKVIVGSSRLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ11</accession>
    <name>A0A8H5LQ11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ11"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5365735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="352" mass="38810" checksum="90182D2E5408D3A5" modified="2022-01-19" version="1">MRFITGDELGSIKILRYITQVTDGPKAELKIVHTGSAAVQKLSALRSSDSTLIAAAYSDALVNIFSLQNNDSLQRISGWTESRLKNDQRFVGLALSNDEPDPSEPSKSASVPTRLLDWKLSPTCQTFAYGGDEVDLSIWNVERSFNSQPEDKSSTSTSGKRKRAKDGLFSAEEWRAKNTPNDNLGLRKPIRITSLSYIAPSDSHLLAGTQIGDVRRYDTRAARRPVSDWKGVAKLGGIKVVECGSHEHEAFVSDGGSNLYSLDLRNGKITYGYKNLSGSVSSIAVAPSMLGSVAQDRYVRIHSTYPPPREVGQQQEQRGEILEKDLQQEYPDLNRVGRIGPVNHFANSRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQV8</accession>
    <name>A0A8H5LQV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQV8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="274" mass="29094" checksum="5D9B513423DB181F" modified="2022-01-19" version="1">MPEQTHIGIGEESARLLTYNTRITVTGSQDLTRIFRGQPLSAELIDDAIKFRDSLAASRLGALPQDVAQSNDYRVSLVFFALSTSFPGKSAGSHCSEMTILKNAKDGMLMGCNITTVQGDSYIQEFHGPLPNMAGHYPGCNQGHTRPASPLSAEDKSQQLSSSAEVSLAWNSARVLEGSTNSLYYGGKITQIGHDTGRIRIIGPTSQEKQLPSSSTAGSSSSSAPQLSPQDATVITSGQRGINIFTDGEGNRLVESDIYVLGQSDGAVDIELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQZ0</accession>
    <name>A0A8H5LQZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQZ0"/>
    <dbReference type="OrthoDB" id="3060439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56700" checksum="AFFE931056A31A07" modified="2022-01-19" version="1">MSNDDIPTFVDEDFDLNTRQLQSLQQQINSYDEQLRTLENREHVLEEQRNLAAASLERKRSLLGNIRKMPVELLEKIFALYCHDKHEADRGNHGVYAPFTALSHTCSLWRQVAPHAWLTIMLDLDVEITSAHVHILTHHLSVVKKMPLTVDVRCFDYHKDRQNARLVFEMVLGCSAQWRSAQLIGSGCFSWLNERERRLSLGRLDSLTFQAWLPGVQECRELSVILKYATNLRQLEADTCDGVALAEICPPRTVSTVTVLKIPLYQLLDLEMVSSSSCLNLQRLHLDFQWEPSFPNPFTDQPINCLQSGLSHLHLHTLMEPDDLDLFKHLQLPRLETLDVKGNTDVDLKEPLKLAPLVSMLSRSNPPLQRLSLKDVRPHQGELLQILRRSSSITHLDVDMSEDDAMSDDCFLRLLLVDPKSITRPLLPSLSTLEVSLLRYFGYGQFTLLKAIANMLESRLTGFKAGRVVSLSFFSLKLGHEEVLSAPDVLERLAAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRN5</accession>
    <name>A0A8H5LRN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRN5"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF28">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="13628" checksum="41213D39615D1A56" modified="2022-01-19" version="1">MSDLKVDGFQSSALISSLSTAFTNYSPAEKAEQLKKVNGIFQLNVKNDQGTEAIWSIDLKKNGEVYKGPAKPKADVTISLSDETLGQLASGKLNGQKAFMTGKIKTKGNIMLATKLDGVFKATKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT35</accession>
    <name>A0A8H5LT35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT35"/>
    <dbReference type="OrthoDB" id="3006100at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52911" checksum="275ECD46229E6F13" modified="2022-01-19" version="1">MSVNITSLAPEILGEIFQHCSFYCSDAPIILAGVSQAFCRAAHGTPCAWRKLRLSLTSDERRLVRKAAFWFNRAGSCSLDLFVDITATEESQSSVSDKPIAELYPFLVAFLRHHRPRIQILNVRSDTELKAFHFIDAIYSSTELPSRPDLQLQSLRIRITSDIPVAPSTWSPVFESFSQLPGLQSLKLTNHVLPALNTPTIAHLRFLTISRPLRAHPLPVHKILRIIGSTPALERLEVDSRIMKQPLSELAQYTNIPLLKSLSLRTNNLSYMLNLIATPSLEKLYLDDLDGKRPTASQELSAALEELSDKVGFTGEPASGLSCLDTLEVEGVSFSAGSGDISMDQWELCIRRMSSLTRLMIRNFDEEELVNILTSTSGLDGALEPVCPRLSYLCLSGSKALIPLHKLNILRPYITVEWETIQERNHQPSSSVYVYGAGGFGFGSRFHFEQMATKVESRNRTVIPRMDPDSDGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTE2</accession>
    <name>A0A8H5LTE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTE2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="222"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="82408" checksum="4EB11FADC380ABAB" modified="2022-01-19" version="1">MRLLNTKSFKLHEFQTNIPPYAILSHTWDKEEVTFQDIQNLQTAKRKAGYTKVKTACARAQRYSFEWIWIDSCCINKESSAELSEAINSMYQYYEDAVVCYVYLCDVSAKEHPRDPRSTFRDSRWFKRGWTLQELLAPIHVVFLDKDWTRIGTRSSLRDVISAVTAIPVGVFEGRDVAEYSVAQRMSWAALRETTRPEDTAYCLMGIFGVSMPPIYGEGGAKAFMRLQQEIIKISDDRSIFAWVASEESGKKERGLLARSPYEFRMSGEVEASKSDDISDRSSYSFGNNGLRIHLPLEEFTDSSSSSSHRPHGKDIVLAFLLCQSSKDSSYLSIYLRKTNGKQYVRCYPDELVLKPSPPSLDNLSEITVREQPVPRQLRWTDQYTDSVVYHVQLLPSARHFVPDSSSSLSPASKSGTSLSLAWWGEAALTYKHQATRENAFTLQFTRQTRVSSYTLQISRRDGDVRTFSDTSDPHMGRLLGRVDKGGYISVTCEMGGHPGARSLEVEYIPVPRDPATIRLIMAPKMLPPDSGFLVPFTFAHLQLEEIYPPDLFGKRLQNMVYVTSFNDSDYGTSFDVNTASASLFTGFRLLTFSVSDDLLAPDSPSFFHVVLGMQREGPGLGSRAAPWVDVILPRVKKTLPNAKGSLEFELENAEQVWRSYASRSSSSLSSDLLKATQSETVTGADAIASTYNDFDSYWRLVVVVENRKSLQLGSYLLRMKWEPRSWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUR9</accession>
    <name>A0A8H5LUR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUR9"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="465" mass="52259" checksum="109921C9573A72B7" modified="2022-01-19" version="1">MAGTLIIVLKGVSKKRAYPPGSPNKNVRSKTRRRVQSSDGQELIQSVFAETWAAFYAWECEYARESIKSLSSVLRTTEVLPTASARASSAEDFISAFKGLKLDSGPRPTNNVFTGFATAVCEEFLDDIECINIDIPPPGEGLSSPPYESCTPIKTSIMKGDDSHYMPFIPFADDPGFKFEYHIDRYKYTAWQQHDPDKVHKHCKADIVGVGDGDEFFDLQIITFEAACQLHNIYKLNFEQIDKANVLPLRMLTSDESPGLLDLIPKLSHPRQITKHLMPQNNLQLSPSKLVSRSPRIITSESSKVKVEVSNFISRFCHRLSCSTSYCSRHLDSSSPPLKIPPKLKKFDLSQSAAEACGDNCFLHLHLSGSVSPVYAASKEWTKDDTDILEVVLHSAPDASPCDISIICRKSCQEVFEKRTQMIPDAQVELLLKRDKKRRPVKKRRPAKRRVESFKDSNPYNFTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY11</accession>
    <name>A0A8H5LY11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA damage-binding protein cmr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY11"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="762"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="846"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5373551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113712" checksum="9098597FFF8E8A81" modified="2022-01-19" version="1">MLISPTIFFCRSTSASLPSNNSFWGRFKPKNKEPEKPPQMALARTRLLTLAFGEMETIRTLPNSLAELEAAARDWARPPPDAMFSLRVPIEFASIQAARLVAGDFIYLTSEESYQIAAMGTQGLRVEIVSDAPPPPDEPPPPPILEMDGIFNLELVPGQHVELETTVTSDELDMARMEDGTTVDGVFWGKLNIVHSGDTHKMEFHGTRLVNQIENTPDAMFDSRVVARLAVASKPTTAKCLLSILSPNMTYCDVILVLSPYWKLGATWPPAEDLGDSKYKYFLRVHPGGALEHFDSNMVFTSLYYEVIPDAGLVDPEDIVAPRNGYAMSFGDFIPHLMNVMDQLGLSLHARTTFINNNMGAFSAHKNIAYRFLPPSKIAAAVDITVTCDPCLFTRLFLVFRGMTDDEVGIFAGAGEKEANAANWREVVGWSEDSKDATLFRVLEISVLEVTEREREANIARNRALLEQLELKQAVQDLGFPAKPRPSDTKAKPVQPAKRVKKEKAEAEAPRRQSARLRNTTVDPNETPAKKRKREAELEEQRAKEAEERIEAEERARIAKRPRHDDLDLTTLVDDEDAQEIPSLSSELQGLGQISRAVGGLEDSVESEDTKEHERAVADLKKRMGGLKIISRAKVTQDRVYCAAYHPEPSKDLIFFGDKHGQLGIWDARAENEVAGDDDDEAADNQEGGKYWRLQVYTTSYDCTIRALSFTSGISREIFSSEDILLCSMDTVPTGHEMWISDAAGGLTHLDLREAKSKAKWYQLSDNKIGCVSINPTRPNFLLTASNNRSLKIWDVRKLQDLSSAASSSSASTSDATPTIDFEAEDINKFLESDEGSGCLRAEWRHEKSVSSAYWDPRGRNIVSTSYDDTIRLWQYPPSVFGSDEDFPSSRPFCHIKHNCQTGKWLTILRAQWTPNPDVYPHFTIANMDHSLDILSAKGTLIAKLADRSKARLNQFVAGSPRFKLSPVPIQVLLSESQVETRVDDACWAIQRGNLQVVLHSTTAEQSGVEKPKSYKAALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY23</accession>
    <name>A0A8H5LY23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY23"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="45458" checksum="40DD295AFEF0D56E" modified="2022-01-19" version="1">MFTTTIRSRHRLSRLFDLKAARKVRWNSSAAEPPPAGGHAPSVANSELLKSNRDSALRTPEILWTGDGPSSTLVSGRETRKMNTYQAVRDAMSIAMTKDETAVVFGEDVAFGGVFRCTMGLAEEFGRERVFNTPLTEQGIVGFGIGLAAMGHTAIAEIQFADYILPAFDQLVNEAAKIRYRSGGQYNVGGLTVRTPTMSVGHGGLYHSQSPEGFFMSVAGLKIVIPRSPIQAKGLLLGSIRDPNPVLFMEPKILYRSAVEQVPIDDYSLPLGRAETLISGNDITVLTWGTPVYHCETAIHMLNAPPPSIEKHIPTSLRSANVELIDLRTILPWDIETVTESVNRTGRLVIVHEAGMTLGVGAEISAQIQKRCFLKLEAPVRRVTGWDTPIGLQYEKFNIPDSLRILDAIVETLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AX24</accession>
    <name>A0A8H5AX24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000535">
        <property type="protein sequence ID" value="KAF5311737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AX24"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903:SF1">
        <property type="entry name" value="HYPHALLY REGULATED CELL WALL PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5311737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1257" mass="132373" checksum="0B6E6545A78DDE6E" modified="2022-01-19" version="1">MARGRNPNTNHNRNSRRKHEQGDINDDNEDDLDPYSDAYGSGYNYNPRTSALSVQSSYTSMAFYMPPDGSGRMVDPYGDEFNEGWSYYTTGSEGGEGEGSGSALNGPGPSFLGKHFSYSQPQPVPSGSASGPSYSSRYDPHFRAHSPPPASPSPSYKTISSQPSTRAPPRKRDLYGHSGHGHGHGGRGARRGGKPRGKGKERDRDTDADRGDAPEKDEFGRDIPRPVPVPGPDKDGFGRDIRPVPLPAPASDGNEKWDPYADPLYLSQRPLRPTHLRPYIPAFVSYLFHEETCKWLDVMVWSSAQPHSVRDMVGRVFGTRAGGAGGKAGVGEGGTKGGGGGGGGGGGVGVQVGEGEGGGTKGGGHLGNYEESHYAGEPGNESQADAQASAKENEEEKKKKKPGLIAVWARDTLGLDQSAYSEFLSFEFRFLLSFSSSFFMFMFMFLLHHTKTQTTKDLDKPWEKLTPLIPGNEFLTEMKKQMEAEASTDADAEAEAEVGGADADTMTTSTTPAFASASAEGAEDKEKDEDTAPIPGSATTSTSTSTSSNNDANAHAAPLAPNADAMHPTPYTHSPLTTLLLDDSPLKAQYSRDVWARDGRVVTSFMSFGIEGGEDSVADAVPGTAIDMGGKSAEGSEEREREREEGRGVEATEGPTETETEIPIDEDAITEDVVANTSTDSIAIPTVPNSPATAKQLKRKRTLNDTGSMVDISASIPTIPISTSPPLVKGSLPLPSNVNLATDTDIGLILQKTKSSLSDMSISVDSRSSASVKTIATEIIDDGDPLANNLNWGGGGGGGGGTLDMDISTDGHCHGLDYDGMPPPPLPPISSSLPLPLHATASQSFSGVGVNGGVDRGANANDNPGKDKRIPRKYDETILAVIGVLDAIKLESNVAAWMRGKRIFSVVEEDDGYGEGVGNESQNGIGNGIGIGESIDTDGGSKEKGKGKATARAMTGETDSEEDDEELERLYERNIAKSLKDTTTTTTTAISTAAASTSIFVQPAGVGGAKPKKERWRKKRKVDLGQTAGGGASRGDGNVGPVATTTTLNNTNNTNANTPISSIPAPLPPIRQAPAPASGVPAPVTTSVVVNPDAPMPDVNGADFSVSNPSIAVVTDTDMLTNEPVQQTSSSPPPGPPSSTPPDSNNPSFDGPSAPSTSTSTTLDTTKATQAPNTSFPSLSDSDEIPGLGQFVFQGNLPPPEGADVIDVDAMDLDTINELAELDPNRWFQYRQVRKYWIRRGRKALEELGIDAEGNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B5C4</accession>
    <name>A0A8H5B5C4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acetylhomoserine ami</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012105</name>
        <name evidence="7" type="ORF">D9758_017994</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000487">
        <property type="protein sequence ID" value="KAF5316847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B5C4"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5316847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5343915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46454" checksum="59437531FEF4B998" modified="2022-01-19" version="1">MADQFYKAPEFDTIQVHGGQVVDPTTNARAAPIYASTSFVFNNSQHGADLFGLKAPGFIYSRIGNPTVDVFENRIAQLEGGIGAVATASGQSAQFLAISAIAEAGDNIVSSTFLYGGTYNQFKVTFKKYGINVKWVTDDSPTSFAAAIDEKTKAIYIESISNPRYTLMDIPALAKVAHDHGIPLVVDNTFGMGGYLIRPLELGADIVVHSATKWIGGHGTTIGGVIIDGGKFNWDSPKFPGFTQPAEGYHGLVFKDLGKAAFGIKVRVELLRDVGPCMSPFAAFLLLQGLETLSLRGERHSRNSLDLAKWLDNHPKISWVSYLGLPSHHSYQLATKLLRQGVFGGILSFGIKGSADQASKLVDSLKLASNLANVGDAKTLVIHPASTTHQQLTEEEQVKAGVPPDLIRVSVGIEDIKDLIADFDAGINIALPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6U2</accession>
    <name>A0A8H5B6U2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000470">
        <property type="protein sequence ID" value="KAF5317642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6U2"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5317642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="663" mass="74192" checksum="1699A86D75F96992" modified="2022-01-19" version="1">MAVSVDFKRLFALIIGIDNYEDPSIQNLSGAVLDAENVKNCLTDTLGVLQSNIQTLYDTQATKVNILNAIRGLADIPIAKDDPILIYYAGHGGRAPAPAGWFTSDSSNEIEMLCPHDFKQSGSDTKDGQGIFDLTLAHYFNDLADKWENISVIFDCCHSGSATRDDKVRDDERVRGIELPKDYVIPLSVFEQQVDRACRRDEKAGERSYGGYFTSELLKLFNARGPEGISDLTYQDVIETINLELHTLWQNPQCVGAKQGRLLFSTTVPGPDRASLIGISTKSDPGEFRLDAGEADGILKGAEFNIYSDKNMTNFVGKVIADAPRRYDTTCRVADDVQFPLDLRTAFALPVHIGLGRDICLFVPSDTVFSELRTALTKHMQRRDKMQGFCLLDSEHDNPPDGPRADLALRVVKIGDDSFVQFDVKDQKCIDMGLTKMPYHVSLCSNEVLMTVLRCAADFYWKFRNNPSLSSYDITLECFELEEDPNQDTFKPKNDRQNLINTDGMIILNSVTRQRSDVATVPYGYRINNRTKKSFYAALFYFDFSSLSIVSLYIPDSARRGKLEFSIQPGSCVTIGYGDSGTSPIEFRMRREQDVAESILQREQDVDVGFLRLYASTHCTKYLDIVQESPLEDLTRYTQAYTGGSKVVFGTLTIPVVTKTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7Z4</accession>
    <name>A0A8H5B7Z4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000452">
        <property type="protein sequence ID" value="KAF5318285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7Z4"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034644009" description="Methyltransferase type 11 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5318285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25492" checksum="4A9BCB467B3893C8" modified="2022-01-19" version="1">MLIVYALIGSWVLDFAQTVPPSVSIHAVDTSTTFFPTTHPQNIVFAKHSGTALPQTWTNKFDFINQSLLAGCLTRDDWIQDLQELFRVTKPGGHIQLFEPSFESWDCPPNSANGKMKSMYKVLFDNTSLIYDLGVKLPHMLLDTGFVVVGQHKSTFPVNTNDGAPVQQCVGMMIRWLRNLQPPILRFGLLGSAEEYESLLKEMQEEWNHGVPTENFFVIHARKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B920</accession>
    <name>A0A8H5B920_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_019007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000446">
        <property type="protein sequence ID" value="KAF5318885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B920"/>
    <dbReference type="OrthoDB" id="2752996at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="91"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5318885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="535" mass="60713" checksum="BF5AC9A4F86BB454" modified="2022-01-19" version="1">MSGLPRVKAEGWMYSPTPVYATCRRTTRHTPTEQPEDYEKEPDESMPAENTEVFDYRISTSGNLSDIFRIFTDDVDTSNEVLIRKVSQGNGESEKIVATDGSCTNNGQEDAIVGAGVFYGHGDATNQSIRLPEQVGDTKIIQSNQTAELVAAMEATEPIAKTIQITLETDSKYVISHLTKSLRKMEDTGYINVNNAEIIRAMIARYRLREAPIHVKWVKGHNGHEGNEEADALVGRATTKVTEDQLVLDVPPKLRITGAKLKMLTQKLAYMAIRQRKSAAMPDRPRTRNVITQVKEQAQTLFDISPTDSVIWTSIRSKDLERKTRYFLWMIANNAYMTGTQWQRTGYTEEAKERAVCQHDRKIEDIAHILSGCESPGQELIWDLTGELWEKKGSSLQWERPALGTIVGARLAVLKTPGGARKTGEERLWRILIAESAYLIWKMRCERVIQKDNVPFTTREIENRWLHMIDERIQLDRCMTNQKYGNKGISPNLVRATWQGLLKREHTLPDDWVTNTGVLVGIESDLRRRTGPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B965</accession>
    <name>A0A8H5B965_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_018529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000438">
        <property type="protein sequence ID" value="KAF5318981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B965"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5318981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="635" mass="69943" checksum="EC9671DA00F2FA0E" modified="2022-01-19" version="1">MSSANYIVVGGGLSGLVVASRLTEDPKVTVTVLEAGRETFHTENIDVPANLVANWTNPNYDWTFMTAPQKHADNRPLYQPRGKSLGGSTLLAVGELTRAGSTEYDAFEKLGNQGWNWDGFLKYMKKARLPSESFHYSPEDAARYGMKFETSAHGNNGPLQKTFPQYLDVFVEPSIQAFNGIGIPVNPDPNAGENVGVFVAAQAIDQNATRSSTAAAYYEPIKSRPNLQIISHARVTRLLTDSQSGSEVLIKGVEYLQDDALKTLNASKEVIMCAGSFQTPQVLELSGIGNRAILEKLGIPVVLELPGVGENLQDHLALTCTYKTKEKMQTFDVVMNDPDLLKEQKRIYTQEHRGMLGAVPSLFSFMPFNLFDKDGGLATAASKHTIDSSCLAAHKTLEMQKSWVHSEKIPFMDISVFDRFMPGGVFEQGISYITFTCMTLHTFSRGSVHVGSADPVASPVIDLQVLDNDVDMGILVKVVKLARKLAQTEPLKSLIDGENFPGPAVQTDEQIKAFVRQAVGTTYHPIATVGMLPKEDGGCVDNNLKVYGTRNLRVVDASVIPLHISAHLQSTLYAIAEKARYQPHENCGDTKYVFRLPISSRLDCEVLQVQTRFPLDFDFFVVFRSEAPRAILVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BBK4</accession>
    <name>A0A8H5BBK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000414">
        <property type="protein sequence ID" value="KAF5320214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BBK4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5320214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="101" mass="11553" checksum="536D32E4806877C5" modified="2022-01-19" version="1">MTPLFMVMLRRKLGREEAGKEGIGNGKGGEDMAMAMEVEDVDMDVAQDLGFGFGLRFGVAKERTLVSTPDPDPYPWVFAFFFYFFFDFYVISLLRGQTHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRP3</accession>
    <name>A0A8H5BRP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000377">
        <property type="protein sequence ID" value="KAF5327984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRP3"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5327984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19074" checksum="EF7917AF0EB646A8" modified="2022-01-19" version="1">MSPPSPSTPKWRVVVGCDDAGLQYKDTLKADLSKDLRVTEIIDVGVGDDDTTAYPHVAVAAAKKVANGEADRALLICGTGLGVAISANKVPSIRAVTAHDSFSVERAILSNNAQILCMGQRVIGIELARKLVKEWLGYVFDETSKSKDKVDIIGMYEKEAVEGAKGVNGLVKEAEKLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRY5</accession>
    <name>A0A8H5BRY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000369">
        <property type="protein sequence ID" value="KAF5328116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRY5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5328116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124769" checksum="1B3EC5E1316693FE" modified="2022-01-19" version="1">MILDNQDATILWNIFFHIHIDQRCLSVLTEQCRTLIAVSGSLQNWSASPYGKIMKMSTEYTLTELRRHWALYTEMHSLPSERLKKLESAFTSVSNSVHNVFVAAASRSAGPLFQSAIEVSALQFTNYWEQGTTSMDANVETTSPLLLNPTFFYSLADEGFNVHYGTDPMQPFHLASFLGNTKGPVSVSDLVSAAQTEFKQWCLAFRSRITSATRPSSALPIMRFFLGEAIAVCRAISLFSETGATTTRIPVSQWKAQTITLNREADGGYGDAPTIFDVIDTSNLCDHVGLLNVLIASIPLLQSSLPSSGVLYTESLLFRGENATKEFAERLYGDITTIGLLIGLCPIDYVSGFSSRSNTHEVLFHDTLKKLQKSSHNIRPGQFQQLITWRKPSFGDPVHGHVADGARVHSFDPWQLGTFLYDMYHKLFEQEDSATWFFMNERNQQAIASSNMIFYSRETFVLFLKLIRQRLRIPSSPWQQIMDRFFEIRDADKSMPMDTYNENDLSAHLHRYGLYTMAYLRPLRKPGLFSKWDSVPMVVRIILSVPRAKLRNVFSGPDVGTPLLQCDIAAHGMQNVFSSLHLAFGKVISVGDARNPRVIIEEDPQGQEGSLPLLVSFIMPSFLLANIPDQEAVNVSFGLRSYPGSLPFVKKLGDMLRIFTAKLLDNEHVHVLPESALVFKMSPSHATPSPSPNPIPSAVRGAGLLNQIGDCEDVMVELDDDCEFVGWLKCKVLVKGDGPLQRIFADRSTPVSATQISPCTMRIVMKGYRQDVVFPFPVIGSWYKVRLARTSMYIEVVVPPYGPLKPDGMKLGLFPTVGVNGNFTPWNIHLLPLDRLPVIDIKVPGTDKWLGTLMGSQMSARERSLKKHERHNEDTLMAVKDTIHSIILCAAGAAMVAGVPQSHPRLVFALRDKASQNCDTIFFISDLRYDLTCHSVVFDGYVLPLSEGLMEKIRVPFGRLVREGNIYNIGTYEGETEAWKQLIPAFVERCRTWTHKPNCEYVSTGKVPLTEEFDEVPICSCGRGKDVDGLMKREMGMWGDFAPYVTRIAISPLFAVSYLEAIVRDPEARRCFVCRGKGKPRIKTCAKCKKVRYCSEVCQKKDWQKHKKVCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0I2</accession>
    <name>A0A8H5C0I2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000320">
        <property type="protein sequence ID" value="KAF5331762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0I2"/>
    <dbReference type="OrthoDB" id="3052060at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5331762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="333" mass="36809" checksum="A09E4E4418D45000" modified="2022-01-19" version="1">MDLFSSPSKVKIEYIYFHLRQKDFIAICNVFVASSLSPNSIITALRLASLKHTANSEPFTIFVQGMTQGSVALVNLPGDAKINGNSRMWQYIFTLPSYDVFINLKNQAQMAKTVRSSNIYYKSSHKSSTESQASVPSHKVTERPDGTFQCSCMKWTQSGKTCKHILAVIMQERFVSVEEYHKLETICAKCGKQAAGIFSNPKKVEKGQHSQARTDATVQSELDAVLQMFEKKGCGNPFAQEDWCMKGITNTGACTSSDAKPDENSGFNLNASLCGQPAEVQPLHLGHSKNAQNPQKNTQKKDTKLVFNGKKGPKAKQKIHPNSLLMAGPEQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2T8</accession>
    <name>A0A8H5C2T8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000276">
        <property type="protein sequence ID" value="KAF5333981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2T8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="95" mass="10908" checksum="2B7486060103E1A9" modified="2022-01-19" version="1">MEDYGTEPETEGEGNGRRPRHQCIDIHVNFDVSLHIPPQKKVPNPPFKKTKTYYKALGSEDAYSPNTHHMRFLTNDFSLNKFLPKSALEHKEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C479</accession>
    <name>A0A8H5C479_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C479"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="13721" checksum="27949870F66BD91B" modified="2022-01-19" version="1">MTSILSFSSTTPVIRSVAHVARIGYPALIRMRSKRMLTMPAAGHHHQYFEPTFSSESHLHAKANVSSFSSPSSSGNTRPRHAGLYDILFGAGIIVPFVAVGAYLERGTHDFNEIPEHVLEFLVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAV5</accession>
    <name>A0A8H5CAV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAV5"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5338415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="303" mass="33693" checksum="6CF15BDE03CA7EEC" modified="2022-01-19" version="1">MSASTPLRNLLKNSLKTSHRQPIASVSRQHSRAISSTSKRRAIPNQRLTFATVASSSTVQPRHAVQRPSRNSPPLTRSMFIQTESTPNDDSLKFIPGISVMGEGTAEFLDTRAALASPLAIRLMGVEGVKGIFYGPDFVTVSKDSEHPWAVLKPEIYSILMEHFSTGQPLFRSQEERENAGPQDTKILDTDSETVAMIKELLETRVRPAIMEDGGDIEFRGFEEEGSGMVKIKLKGSCRGCDSSTVTLKSGIERMLMHYIPEVKGVEQVLDQEEEVALNEFQKLEEKLHKGNKDEPMAQYMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBI8</accession>
    <name>A0A8H5CBI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBI8"/>
    <dbReference type="OrthoDB" id="2751864at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="22337" checksum="1DBB8FFFF2F77C63" modified="2022-01-19" version="1">MSNDVPSQSEAADTPTLVEKVALYSFHPFTDTELATIAKACEKDGYDNGGNEDFIAAAPKPHFTDSDGKVESVIAYHRDLVKSPTDGPDGPVSYDPNYFIVVKSPQWKKEGVLVVTLNEFELKEVPDDGEAVKRGWDAWMFTAKSSGLTILNLQIANMGWTEYTTWDDDQPEGQEVDGRDGKTWYEMHPEEPDEGERQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGQ6</accession>
    <name>A0A8H5CGQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGQ6"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5341552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="514" mass="55964" checksum="B9BFFC174A0E8D7A" modified="2022-01-19" version="1">MASMASGTDSTGTIAPNNRRSKTPSYVLNQDRRAALAEVDNAKFAWFHVKVCCTAGAGFFTVAYDIFAINIATRMLGYVYGHATGPDLTSNQQLGLKIATPIGTLFGQLLFGWLADVVGRKRMYGIELIIIIVASFFQALCGSAPVISIIGVLIIWRFIMGVGAGGDYPLSAVISSEFASTRVRGRLMNAVFAFQGWGNFVAVLVALVITASFKDSILHDTSGTHRPVDYMWRILIGLGCVPGCVALYFRLTIPETPRFIMDVDRNIRQASKDIENLLTVGKSEVDPDAVVQRVEAPRASWADFCAHFSQWENLKVLIGTSWSWFAVDIAFYGLNLNAADILEKIGFGSDKVYDNLWNICVKNLILSASLIPGYWVCFLFIDSWGRRPIQLMGFSVLTIIFICMGAGYGKLTSSDSLKKIVPGEAFPTRYRSTAHGISAASGKLGAIIAQVGFSHLYIGTSLCILAAFMFTGILSTLLIPETKGRSLEELSNENQDEFVKGIAGTAGVRDEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGS0</accession>
    <name>A0A8H5CGS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGS0"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5340478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19020" checksum="C2295D9ADD5EB471" modified="2022-01-19" version="1">MSPEETYDQFNTNVFGALNVTRAFLPYMRQRKTGTIVWMGSLAGWISGATGGLYCATKYALRGISETLHDEISPLGFAVPASTLAPYESRIEDYREMGKKGVEGLEAYNNNQPGDPAKAVQIIIDVIKGEGVAKGKPFAKSLQLGTDCYGGVKNAAEQTLRNLEAWKDVTCSTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CI87</accession>
    <name>A0A8H5CI87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CI87"/>
    <dbReference type="OrthoDB" id="10678616at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034178351" evidence="3">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="414" mass="43586" checksum="3B13FE9FCB9F9362" modified="2022-01-19" version="1">MTLITFTLILFYYLSLAFCVNITDDSSGFTCAPNFELRWQGGTAPYTAAVQFDCILKSTGNGNSTGTKSTVNNASSTIAIPSGLNSIKCTVIDNNGENDVLTLHVLYRFDAHPGSNAAQCGGTGDTGNNTGTGGASGTSNPPTVSTVSSTNDNNSIQRSPDHSTGASNSASITITTTAIDHGRTTVASPLPSLPPNQNPQSNPQGNRISPGAVAGAVVGSVALIVLFTVIGLLIYRRRAAAAKNKVELQRVEPFYPGDSPMLATPSTTRSRLTGMSSSSTFPNEKSARRHVHWQNRDTRSSLPASLSTRSASTTTTSMAPRSPPTATGDHFQVPQVPPAALILDRHDSNASRVEVQNQPQSENDGGQGPTLSMETVPANWEEERTVLRTQVGLLMSVNAQLAGLTPPSYSESRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ71</accession>
    <name>A0A8H5CJ71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ71"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="252" mass="27487" checksum="92303DD0E82A974B" modified="2022-01-19" version="1">MTMPVQYLCPVTMDGRFAKMVRVVPTMLPQPQACSQDIFQKRYFILKTLSQCDLDLSVQKGLWATQKYNEGILEQAYRTCKEVYLIFSVNKSGEFYGYARMAGPVSYIDESTPEVPDSPSRVESPWQPVSGLGDASPASLHTVLDHLSGFTRLELVGEQRDEDAGGGLSRDGTALEPSIGQQLIDEWTQIAIESQSQQQPETTAATAVSSATSPSTALIEGNPTLASERTSTNQPSVFTVSSAKGSHDIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL51</accession>
    <name>A0A8H5CL51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL51"/>
    <dbReference type="OrthoDB" id="3251442at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="39460" checksum="148A291C247DD95A" modified="2022-01-19" version="1">MTALSLASLAKKVVASIKVDMSSSSDSLEGVALLICSAWTWEDHYSLLNQSVCVRETSYDWKYFVDPCEVALGLSTDSFAPFKKWSKTTWPIILVNYNLPPDVHCHLKHILSLGVIPGPTKPHDWDLFLWPLMEELSVLASDQGVPTVDILQDFKGMSEGNEEYQFALSVWEAVGLATAKAGDTIPSTFDGRVPNIQSKKSEMNAEQWSFWALYIAPVVLCRCFMKPHYYNHFVELYEISREEIDDLEAGFSKWVEEYERSEILPSSPKAQHCTQKSPSFAMQFGSKIGNVRKALAMAVIEEYGAVKRIDSEEGDTMCCSSLYKPPQDSHDPTFVQSQLILTDTSTVFNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNU6</accession>
    <name>A0A8H5CNU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNU6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="90" mass="9434" checksum="4A7012055A9D9FBB" modified="2022-01-19" version="1">MLTPPSSPVKTKSNQRQREEDDDDDIANADADAFTSTSASTSVSASTSISQSTSTSTSLSTSVTSTCTCTAQTSLCPRSQRLPVVRNDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQI0</accession>
    <name>A0A8H5CQI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000106">
        <property type="protein sequence ID" value="KAF5346025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQI0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="59" mass="6605" checksum="C8141219DFD4522A" modified="2022-01-19" version="1">MLDAIKSSSQKLCNPIYSRNLITLPLPIGPLLITPAAALRLHFAQDTLTRQERIDMTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS83</accession>
    <name>A0A8H5CS83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS83"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="191" mass="21275" checksum="E95CD09F0FE26DDD" modified="2022-01-19" version="1">MCASSLNHAPSQASGTTSFGVRDSMRQAESGDEWVHIGDVKWGGEREGAEGRGVLGLGLGLEGRGRVRVLVVVVNNLRKRGGDITRMKDMKFQALMYTIEHPAIDHWSTDAKGRRIPSISNADRQNLQEHSDALEEQMQKFEVQSQSGVVDESHLEAEMREMLARMDMLTRKMVRVLVPAYDSENSSEFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUF1</accession>
    <name>A0A8H5CUF1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUF1"/>
    <dbReference type="OrthoDB" id="2961574at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="294" mass="33761" checksum="68FAD80C5C45C0BF" modified="2022-01-19" version="1">MLKLLSVLKFRIHNSLGRATRRGLSAKSRTGRPLKRVLISMKPNELTSFDYMDISGQRCIGINYRNAPCRKIRWEVSKTSERPFPERTHGFFYYHLPKNAPLFAGGVRFRVCPSDDTRTFQDGDDLLKLSGLPWEISNWAFALHKTYRPWGEEMVETGVIRPGALELCRKLTSQVHLHHPSDNPVIYSLKQPFSMPLGLNKIIFWIANEKNMVRVLLRSRILEPFNVTLKMPVAATADVCFDRVEGNIVVRLLSVPPEYAGKMKYKVGDTIPYRPTRPEVLDMLKNFPRPAGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXN5</accession>
    <name>A0A8H5CXN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXN5"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5349862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17270" checksum="235792C5A3408D37" modified="2022-01-19" version="1">MSSFPLVKPLCLIVASISVWICQTSPNPRPKEHEIAVKEPQLVSTKGGSMGKYVPVIMLILEALVVQFSHFLHQDLQPYLNANGVTSQPSTQFYIGISILFIAGFIRYRCYAELGRHFTFEISVLSQHKLITTGPYSIVRHPSYADLASVSLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0U0</accession>
    <name>A0A8H5D0U0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000070">
        <property type="protein sequence ID" value="KAF5351435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0U0"/>
    <dbReference type="OrthoDB" id="3127385at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="509" mass="54863" checksum="247FA1FA991D23E3" modified="2022-01-19" version="1">MSIIWAVADDDDSRVNYTGQWSSSSPQTLLDASVNLSAGRSFFALNNTLHGTSSNNASFTFNFNGTSPSPKVYGSIANDAQFKIECSLDDLRGHPSEWGGNQSLLPNSIINNVLICASPPGLKPSGTHQLSIRVFDVSKGALSTGVDVFYLDYIAYTPLSDAPVDGEYVLVGNLEGATSPPPVSPSSCDIICPEIITSTSAPTTPSPTPMSPLGDSARLESSPGWEAFQNGTLGTKFPGSTLTLTFNGTEVGMLADSFGALNSSNAVTYQLDDQPPVGLRSTSPNPGSGNETLINPDKFLLKCTSLFPDPWFEVQFFTNTLTSNVDSSHSGTSTPVPHTSETSDPIAPTSSDHHSRGGEIGGIAGGLSAFLILALLSSWICLNWKKTRKEKMLEPTPFVVVAGPDFNQYENRGSHGIPSSKHLHYAGSRDHHESDDMLNRLRWGNLKLQQRVAILLGRSQSSLQPSTPENRRTRERRIHTDSGWRMGQDDLTSDHSDETEEVPPNYTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D242</accession>
    <name>A0A8H5D242_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D242"/>
    <dbReference type="OrthoDB" id="2836053at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5351316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="300" mass="34284" checksum="53707C762A217EFD" modified="2022-01-19" version="1">MATSTSTIITPYLPVELIHLIILTFWNTPSTSLSSKDRATFMKSSLLVSSTWQAVFLEIVSRDFYIPDTDYAHKLLDALKDHHLLPFKSTTLSPESSPMTTLVNILPTRCSRITFQYTQTVHKISRSVILDCKPLSSESFCSPSCTSPSCSSMTRARVQLAYRILQTDDKLCCSIAATGSELDHLTHKREQWRRAIQARTTKDAREALNLHPIHANSSFVRRVLHFVSGGNTTRLVRLKRPCDIDTSMELDLQDQLDWLLDIQRKQELSEDQELEKGFLEKWIWLIGEEKEVTLTDLRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2J0</accession>
    <name>A0A8H5D2J0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2J0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22180" checksum="B3825B493E4D8981" modified="2022-01-19" version="1">MVHFMSFKQAMAAGIKKILVTDFIIQNWSTENIDTSDPDTAYIYQRCKIATDRKIWEIACKHQDIDIAVLLPPAVYSSLVPNYPLTSCGNLGMNDIVYQFLLSVPDMHPNIPFGHMVDVCDIAQAHVAALAAPPVLGCSKRFIVACGMFTWNALVELIRKKHPELTDRLLQEDAKIVPQYGCHRGSCRFLTEGQLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4K2</accession>
    <name>A0A8H5D4K2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4K2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="17246" checksum="EF6B2C859944499C" modified="2022-01-19" version="1">MQVFCAPSLIFPNLRTLDSSKSREEVDWALSFMHPGIWQTLIARTDNFKLQAFAEAIPVRMPALTTLQLSGTPKPEYIAPILTIIRALPCLTQLHLPGFQDISPFLTHLGPLGKIRHVSFGNGFVGFPVRGPVRGPASSKGFLPSPPLTTFIVWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D820</accession>
    <name>A0A8H5D820_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1726" mass="192605" checksum="A4E0517D350CE829" modified="2022-01-19" version="1">MALQARDALWSSGVDESVEVNQRALIDKVLARYSGEFTVFRELLQNSDDAQSKAVEIRFETKQYIDSKSSASLETNSESVGRPLPDLKTALVHQWTFKNNGIVFRDEDWSRLKKIAEGNPDEEKIGAFGVGNLFSVTEEPFVTSGGQWMGFYWKDKKDQLFARRGKLPEDGPAVEWTSFEMSLREPAPIPVPFDFARFLASSITFMAYLSEVSVYFDDKRLVKLSKDSGVPKSLGIPKGIQTSSKLNIMNVMNLRSTPLHIKAEVMGLVYSSGSEKLPPPSASKTLRPPQSSGGFFSSLFSGFGVSTPQRSTTPVVPQPAAPPVDPLSVNETSVLLSIFTADVNVKLDKKISAELHRSTKKNPPSKLKYELIYTGKDQYDASKKEDEQLPYTTGSVFQGLRADLEGTGSARIFIGHATAQTTGVGGHMSSRFIPTVERESIDLMDRNVAVWNKELLFVGGVLARAAYELELRDVQVSWEGALSSPLSKPDPELKSWLMNRSIHALKFFTFHQSTPSADVSSLLESTFFTCASGHKFTLMSTVGVRDVSEIRLPDSSFSFLKELPVVPEEIMSEARSMITALQNRQLIKAITFDDVLKELRSRPLSEVELTACMEWWVKLNSDGNSQRYSTVRTQLLDATVLTMGQPGGPDEKIIPLNTIRSFLNPRSQQLAGIPSDSPLPDNLLPPSISRNFTPDALFSSFGFRELTLTEWLQYLCSPAMSTKPEYDMGLSAPWAEQVLGVLARAWPTLSNETKGQLVALLAKKACIPTSNGMKIPGDSYFANADIFHDLPVVTLPSGAAVKSTMERVLTALGVRKHVELQIIFNRMIKTNEWTIPELIKYLASVQSTLSADEWQRLKLTAAFSPEVPTADNPSKRLRAGELYEPLDVFRHLGLPVIAWGAQNKWRSSSPEAKLLFDLGLQRQPPLNTLINLCASSTPDIRNSAFQYLIENVDTKYKDYKPVDYRNVKFIPALKDGAPYLATPDEVYSNQDWVAFGFPVIGPTAKDVSLKLRIREHPPSAFLVDFLRNTPPKDAAQARRWFEVLAGRVADFSGAQLSQLSQYAMVPASQSEKGTVQHLRPDHCYFGRSGQDTFHSKLFTFVDFGTLANNFLSACGAKQEPSVDEIAQMLLANPHNFYQLAGGPTNFFNELRNIAVNRRGLSSTTVARMKKSAVLLGSQRKILKNEKGTNSGDYDDEEWDLQYDLKRPDQIIVADDTHALQLFGSSLFCAPQEDMLEDFYLVLGSRRLSSIVKEEYRTTVEVHDPRAEETRALILERLPLFLHEYTHAKTKVTYSWLNTDRNFVVKTFGKITVNKSLAYGDLRLSKSQDASAVAKRLGFGPMQLWIAANTTVDMYEVATSLCRLFFESPKANDALLFMTILSTDLRSLKRRGYNVDRILREQRAKRQAAEDAEKARLKAQAEAQTLPPPLISNPPQPSIPGTISPPTTAPTLPPPVDEDGKALSRPRPPSIRNPIQRIRDRFTGRHGSDDLGHDSMSFPTTSSSPLPPKPVTQRNPTQGATPISNIHANIDMAIQACRPESGGLLRNREHMQQVKETLNEGYCDISGRTGDLKHIGTMGDVKVYLSEEALSQSETFMTTKHSSLARFIHIITSVGKIYKLPLTSMHIFYDLHGGIIAFNRNGSIFLNLRYFESWHDADVAEGNINTALISWYFTLAHEIAHNLVEPHNSEHEFYFSAICEKHIMDLRRILLVGPAPLRQEWNLKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8I0</accession>
    <name>A0A8H5D8I0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial distribution and morphology protein family 31/32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8I0"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5355505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="92147" checksum="FAFB7147BD6E7EA7" modified="2022-01-19" version="1">MSLRILKSSVFVSCTAHITSCASRKPDAVTLDRYRTIRKFFTLQQKQPGSEFVRVGAPNLRRPRPFIACQFEHFHSSAFRLKKHSGKGFGSHFSREKEKVQTTSSNQQQGDSQEYVDAPDSRLFDSPSTGHENPYSASHVQDPDAPRHHATSSSSETPSEQDTRQQTPFTRQDTNDPPPAPATSESTLHTSSPSDAQEQKQTETPPGTPSLPYNFENYSRSFRRLALSLPHLHRPTRDDFLRVADGFWQRLRIRFKWFTIKSFRKFNADDISGIITWFLMSQTLWILVGTTTFFSVIFAIANSLRLQRFIARGISDYLTSETGITIIFESAIVPKWKDSRISFKNVYISCRPSNYNHRPKKNDGHMAAVGYDVGNHPAYHGVGEEDEEDVPPPVEEDANYTMFDLNVDSIDVTLSLWRWLDGKGLVEDAVVKGVRGVLDRRSVFWDPDNPLDPSAFLHPSHPGDFELESLQIEDLLITVYQPGGFRPYTASIFRADIRTFRKSWMFYDFLSAENIVGQFDNCLFSLHKPQSIGRTTEKDLEDGDWARMSRIRIDGVNIDHLQASTSMQGPVSWITSGKLDAVLDIKFPRDPEEELPFNAILEEIADAISTTLSTAPDPIRQRIPGQRELAKPALSPPEPVKTEEITGSPEPKVVIDIDLRFRDVKAAVPIFTNDLSYVNSALIRPIVAFMNANRTLVPIHCRVVKGVSEFEGAWTMWESGLMDEISLKIYDALAYHVAQANLNRRIKTVSYWSLQKTAGAVLQALRTLVDPVSQQFKETYLRSLDGGVLLQLVEQDLELTQVELEEERQLQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DA70</accession>
    <name>A0A8H5DA70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DA70"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="375" mass="43017" checksum="A4AC3E325E7AE2A1" modified="2022-01-19" version="1">MADAHRGRIVPRNEQYYLNGGDLYLQTDDNLFRVHRYFFERESPKFQELLKRPPPPGKKHIGSAPEVPIMLPDISTEELEQFLWVIYNPIYTIYEGSLEEWVAILRVACRLKFPQIKQAALRELQQMDMETVDRIVLYRENSVDEEHLMPLYMELCARSTTLSLAETEKLGTQAAVFIFQARERLRSSTADGTKSPLPRDLDENDVLVTLHDLMKDFTLNSENRKSIPLAAWAAAYQEALANAKMPARIRKPRPLPPSHREEENNGMLDTVTEVSTQRSVSEHTHDTEVDGDPQNLREDTSEETVIPEQNLRQSEEVVVERVEPEAESETGSCRSLRRMRVGERGGWTLSTVSTPPFPGSWRKTIAPGEDDEHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ER52</accession>
    <name>A0A8H5ER52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001374</name>
        <name evidence="4" type="ORF">D9758_008913</name>
        <name evidence="5" type="ORF">D9758_010079</name>
        <name evidence="3" type="ORF">D9758_019012</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000647">
        <property type="protein sequence ID" value="KAF5309325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ER52"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5309325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5369792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="33659" checksum="BB1DC6F443A0D7B4" modified="2022-01-19" version="1">MPISNPNQLVEEFKKSGEFDRLRRELLAEFQKGEGLPSFKRKLEDIGRETIRTKRAAEIDALYLEKDKKLKLRDDLVQDIKRFPVVERAVADMQMFSDSIFLDGIRSSALKILRKDRGEIVESIQDAKSAITQTVQEVDESVTGKDTHNVETAKDTVEVKVKTSPIPTPTLPVNNPSSSSSTHSGSESAAISPINPTASTSAPVYNTGEQNLHVPDIPKSESAHASDSTRIPMLPEPDTKPSHFPSVAPPPVQASIVSHSGFPASASSSSQSAIEGEEASMGIITMPSSSSSLPPVPVKTEFDSPMDVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EYY4</accession>
    <name>A0A8H5EYY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000479">
        <property type="protein sequence ID" value="KAF5317471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EYY4"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="10723" checksum="F083F59993EAB334" modified="2022-01-19" version="1">MSATTTLVENLTHVVSPPSVISTSSVPPAKEWIPPEPTNEEVEWADILTVDLSLYDTKKQELIDTVQTALERDGFFYVIGHGIPEEILKRQFNIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F560</accession>
    <name>A0A8H5F560_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000389">
        <property type="protein sequence ID" value="KAF5323668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F560"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="87"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5323668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="57149" checksum="9A7101DE31E4ABEE" modified="2022-01-19" version="1">MMRLQPHSKLYIFTLGLIFIIPIIRAASTLFEGGTVISFDESSQTPVVLQNTSLLVTDDRIAAIFDSDSQEDVIPGDTERISAEGKILSPGFIDTHRHGWQTAFRTIASNTTLTEYGSRYSPRSPAESNFMPDDMYFGQIVGMWESLNAGVTTVLDHAHGTFSNETSTAYFKGSVDSGARVIWCYAIQDTPNTFSILDHMANFQELAHMNLEISNSTVEMGIAYDAFSSASMEEVQSVMEFARTANISALSTHYLGGPWMFSNSPQLLNSLNFLNTSFPIVFAHGSFLTTNDALLLRQFNQYLSITPESEMHYGHTHPYSALVQDQAALGVDTHMTYSADMVTQARLWLQSTRLKYYGQVIDQNWRIPSNNPMSVNQAFLLITRSGALSLRRPDLGVLTVGAKADIVVFDGNSPNLLGWSDAVAAIILHSNVGDIEQVMVDGQWRKRDGKLVTKENVNMDEVNQKFLMSAKRIQKIWKDIPLPVLGEDSQDMVLGAGVPFGMTLMQDVVRGNGTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCV4</accession>
    <name>A0A8H5FCV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000307">
        <property type="protein sequence ID" value="KAF5332380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCV4"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5332380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56477" checksum="3F1CE7A157077EEE" modified="2022-01-19" version="1">MTERRSASADPKLRCANRPHVFHPASNQDACYIPENGDDPWVPCKAQPCLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTNQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRHPPTPPSPDPSDPNDSVMADTPPIGSNRTSERGRKPDPFNGERSEAKRWLAQFNNYLRMNKGKYPTEESQVSLFLSFFTGEKGGDWATQRLTERDADEENEELTTTPNQWRWITLKQIRDRFKKDFRPLASEDVARTKIKFARMKGTDISSYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWDDFDEYKERAVELHLEWLKERERQGRWKTTSTSKSSSGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACLACRQTGHMSNDCPTFPKTSSQNTSRTFPSRTIRTAETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFL5</accession>
    <name>A0A8H5FFL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000248">
        <property type="protein sequence ID" value="KAF5335039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFL5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="37" mass="4065" checksum="4A011985A147BD23" modified="2022-01-19" version="1">MHTVYLLSQTHGKKYGHDKGRDDLEAAQDAGEVADHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGU6</accession>
    <name>A0A8H5FGU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_014497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGU6"/>
    <dbReference type="OrthoDB" id="2542103at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034817934" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5336281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="266" mass="29132" checksum="C7DAA3DB116AA141" modified="2022-01-19" version="1">MFGFIRLFSFFLIFEGIVAMVSPYQNQTESHHFQAPGEGDVRSPCPFLNVLANHGYVPRSGKNVTIPDIVKGGREGFNVGPNFFRLTGKKGLLTSPNLDSFNLDDLNLRGCIEMDTSLTRPDAFFAPNNANLPFNETVYQTMASSNPGVDYYNVTSQAQVQDARLNHSIANNPELVNDATSLFARSAASALILSILGDPKTGIAQKSVVDTLMREERMPDGWKRPEDVIDVDTIQPLTQAIMDASNWPGPNNGTYPGAQQLVIFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHE7</accession>
    <name>A0A8H5FHE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHE7"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="135" mass="15247" checksum="1C6150A8E9FB16F8" modified="2022-01-19" version="1">MPFMPSFVIASFFSPAELYAERLRGRKILLENPAKVSRAEQQLEDQRSSKRRRAKNKLLMKRKDAKLNGIWKLEKGRANTGSYLSIIVMNGLHASTSSAATIFFSFWQASGVHTLKDSLSSNGRESGQEVRTVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI88</accession>
    <name>A0A8H5FI88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000206">
        <property type="protein sequence ID" value="KAF5337784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI88"/>
    <dbReference type="OrthoDB" id="3259884at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="780" mass="85099" checksum="2F855807E828EB8D" modified="2022-01-19" version="1">MPPKRLQSNTVDEDDSELDIPCMENKIQATTPEVGGERMASTLPYNFMAELAHLEKQAKELQPRKLALQKKANSEASEDSQNGEDEGEYDDEMGPEEEDEFSYGDNNMIEFAPPSAIMAMQTMVTPTPPCLELTRIHHKTAATPTTSRTPQNAFMSTPLQGQDSEPEELTTPAPAVTAPGNNKQSGSMETSQMANIPKQVIAAAPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPNAPSTANPSDPPFLSFAANYRPSNKPKADDYDSEGKAILLRACAYYKAKIIGVQGFPDHSTQVGWAKKAFDDACRVAGKQYQSDKIVEGILDDYTSPLPLTITSMPPRPASPSQSDNEADIPATEISLKVSVQLTKYTSGTTAGGKKKLVKETKTKELEHTFEASKKSYLGLLTTMLVKFGLARCFTVSENTLYVFKVQIPRALLRQSTDIENYNEYITSVVEKVLESPPSKPITIFIDAKKIKAAKKRANDDSDSEDSGEDDGKTVHLTATERAIAEQRGLLEREYGDPNSNACFYTCPQTKEKVPLTFFMMAEWAHAMVDKKATLLTPPDTITFDPRTRNSSLLGRNRRSSSVSSGSLEGVSRAATSDLGHLSAILGMVLGTRQLETPHPSLRASTPPPPRSEPLTLDYKNTPTKLPRFLQYAEDTYGIQNASQYQFSLENAALGPDVLNDIGDQHLTDLNIAPGNVIRLRRAADAWATSDHLTFKCKSPEEPEPDPHPSKKTVLGLEKRLTDAAGNKVGIERVYGSMRQREGEGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIH8</accession>
    <name>A0A8H5FIH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIH8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="88" mass="9754" checksum="A6BBDA688D7D13C0" modified="2022-01-19" version="1">MLDEGCGTLTKTVMIGAILSKETIPTAQLGAAIIHITSKDFTGPRAITIRVLLDKKKDYPYKVSREFVSEYQIGLLNSLFQFYGIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIK6</accession>
    <name>A0A8H5FIK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIK6"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF119">
        <property type="entry name" value="AT02038P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="596" mass="67394" checksum="0177B0E1BD550449" modified="2022-01-19" version="1">MELADGYNHTTTFLCSKCNATLVIPERFHSPLLYEQLRAVHQPSETEVVQIKFIVSDIDRNLASCDAELMSLNKTLAELDALRRRLQRLRDSHVALLAPVRKLPVELLLHIFSLLCIDNPGLSITTDPRTAKFNTTMPTINIARTCSQWRKIALSNPHFWSNIVVDLGSRPWNVKGLADLYLRRSEPALLTIRVEANRPDGNFEPAAYDEERSLKSLTKDSWSLFQSLLDEQPRWSRASFYLSVEIFDCIGFKEFWLEGDPNNLEHLEVNWTGDVEMLEDAMGTFFARFEVAPALKTLQIKCFESFPLPFNQLVRVQLLSTNPYELKKLASLCPHLKELEIHEICKAYFSEGDPDITSQSLEALSLTFRRFQALDPFLSFLHLPNLTALSLHMKESDNGSDTKPKHKKEFVNGLKTVLQRSPGLHRLSAEGDLFSDSTLLEILLLISPLQSLTLLPHTGYDTLYTKALFDALHFPSAQSASTTPSLVPQLTHLKLEFAEADTVISQGKPTLRDRMVDPAEIVSMLESRHNTLRHFEFHAATATFYEELEDFQPGGAYWERLCVLKAGADSLSVTTVFTKIPLGSCVDLDEEDEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIV9</accession>
    <name>A0A8H5FIV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIV9"/>
    <dbReference type="OrthoDB" id="3263296at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5338038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="436" mass="45625" checksum="4C3FB154A59079B6" modified="2022-01-19" version="1">MDQQFIQRDLHKKRMIQKRQGLFGPFSGPGRGEDTSSSAPAVPPPTSSSSTQIIRGPTSTPGDTPTTSSSTAITPSSSSTVSPVIPIGLTSSSSSSSSSSSTSSSSRSTSTSSSTSSTVSNTSSASLSTPSRNVSPNSGVSGVVTQFTTTTTGASHTATSAAASASSTPQSSGSTGAIVGGIFGAIVGIAVLACVIAFIVRKFRQRRLDEEHFSAAKFRNSAMVIEDDDYPIVQNDALSAGAPSYNNNNNGGRGFGARPPTMIERHMANTPSIPAATYGAYGASNQINQYPEYGYDHQQQYSAGMHPQDVNNLSNPFAAHDPMTDHRGPDMYGQQPAYGYENPAQYQQQHQQEQYVDMERVASPGRVQSPPTEYPAVPAAAAHPATLTPVQAPHPTILTPGQVTQPQQPQRSAPSPSAGVKRPETIYDDEDAYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FK18</accession>
    <name>A0A8H5FK18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FK18"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034408866" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="7720" checksum="EB1F183E06B8F60B" modified="2022-01-19" version="1">MRNFLAATLILFFAQTLALANPVAQSDSPDPIRGCGAFAEPIFPCPQGFTCCSTEGSAENSVCLKLGPGEICLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNB0</accession>
    <name>A0A8H5FNB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNB0"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034711991" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5342822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="384" mass="38259" checksum="E07B789F507ED049" modified="2022-01-19" version="1">MKSFTVILSAFALVARSQTVNYSGAITLGNSAGNCIRAVNNADNAAVVLSNICAGADAQWTFSNGNVRIFGNKCLDVTNGNDVNGQQLQIYTCFQGNTNQLFQYQDNHIAWSGHGRCLDNTDGNLTPGNPIQLWSCISYNTNQRFNWQTTPAAQGGAQPAAVPAAQPRPAAAAGPVATVVVVLQPAGAAPVAVQTVNPQAPTTVTVTARVGTTTVTLPGGSVTTVTTTIPITTTTINRNATTTSGITTTTGNATTTTGITTTTGNATTTTGITTTTGNATTTTGITTTTGNATTTTGTTTTTGTGTTTTGTTSGTGTTTGTDTTVTGTGTTTAGTTTTTGTTTVPTTSGTTTTTGTTTVPTTSGTTTTAPTTTAPTTTASSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNB1</accession>
    <name>A0A8H5FNB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000149">
        <property type="protein sequence ID" value="KAF5343091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNB1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="337" mass="37893" checksum="27ED78201F055FD0" modified="2022-01-19" version="1">MATFAKASFDTSVYATSRPTYPKALFKFIFDYHQRGIDAFPPKLKAVASEEFQERFRRGAAPGWGTAVDLGCGTGQATAELTPFKHIIGVDPGAGMIKKAKEYVAELYPEPTSTTRRGQTFDFVQSSAEKLDFIEDGSVDLVIAAQAAHWFHFPTLYPAISRILRPSGTFAFWVYSELRLPQFHPALTQMITDYCQGSDPDNSLGPHWERPGRTILERHLVDVPEHDSKEIGVEGLGLSQTERVYFAGPYHPTTLPTLRTLPIIMRSQTTWNGLLGYLHTFSSLHTWADKHPGEENLADRFWGDLMRKAEEETKKSVKGENELTVEWPVALVMLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQZ2</accession>
    <name>A0A8H5FQZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQZ2"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18203" checksum="7C3DF1EA324D68FF" modified="2022-01-19" version="1">MVVVSFQKTEDAAMAKAKYDGKFVDGRRPIKIEVITDKTPSSSSSSGSASTEPAPPSLIDRIQGRGNAHAVPSTKKHSLPRQEAAVADMMASSSSFTPLNVTPNPDSTQSTRRRYKKGPKRLKKQTVQFVKVHPTNVNGTTKPKVVGKSKDDLDQEMDDYRAMGEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRP4</accession>
    <name>A0A8H5FRP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="804"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5346302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1414" mass="156364" checksum="9D1A6C0EBA45D0FC" modified="2022-01-19" version="1">MSSLSPGSHPHSPAQSTAQDGAGSSGQPPLRTKRRYAASCELCRRRKKKCPGRDTDGNSLCTHCAEVGVECVFPPNGQTTRARKVMAAAAVSEAEKLKVYIRQIASSNNTDRDRLLRQWLAGNSDHDVEHEYNEDLPESPEEDFKPRILTTETNSNLTWTSLERPAKRRKTSASISQSSWRTSSPPSPLSLSAGPYQTPGPRIPDAFYDDDNHDKEEQDDPSPSSSWRPESALRLSLNPNPNPVPVPINFKTILSPRVEAEAVDKDHDVDLNLNKNGGNHDAHPQNHSLSRSRSRSNLAHAHTHTQTDHNHNYPHTHTHTHTHTHTHPHTHGQNQSHTRPHAHTLSPSTVSVSPQSANANANASTITITTTSSSTSSSVNAIANATGNAGALSALDTPHILIPSQVDRYINGIGVKLSVNDISPEDRDLLFKNYFCWQNPRNCVVDRALFEHAIQTNDSTYFTPFLFYSICAHTCRHVPQLRERVTDYAARAFTLLTPELSRPSSIPTIQGLILLSSHLAARGLYGQSWNLAGTAVAMITDMGCHLEKGKDPPPPSAPTHDRTRRQTKTSKQDQDQSLHHQMRIRVFWAVFIWDKTISLALDRPAHLSYGHRFPPYPQIEPTNFDEENPSLLPALWVPFLSIDSPPALFSYQPQPSYEDQYFYETCRAYRYLDEIHYHLYQRQSHRSGFKSMGPTEINEFVSGMRTRLLKWQEEACREVVLDLKSFELDASQSQGLGKTESHGHGQSASPMAHPPPPHIIQLNLAIRVIWILLYRPFYYSLTRNANTTAKANAKTDSCTSFSRSPTIESTPSPGPSSPVLSSFSKHSTIPPRPSSPKSTPSSSHTTHYATPDAITTCERAAAEINTLFVMYDRLYPLSRASYIIIFAAFLAATIDLALADKQRRALAAGAVSNASVKGTVVKVGSGKNVPDDNGERKRQRQLEVELGTTLGRLALANRVLSGCASVVPGMHSSVSKLQKHVSAMLDGSKVWAGADSGLGEEISSGGDTGSRSGTTTATTISRAHATAAPVVAKVFDQNEKAKNRRIWEEQDEHARDDWRRRQQEPYLQQHQQSHLSAADTVHNSQSRDYPLYPSSSSSFASSSAGYEPIAPIHDHQHQQQQHVSRHHAPAHSHFPSPSSVSNQGYNPSTTSPASTTSDQSRSSPSNRRPPLQPPLTHALTRTGPTPEVLPPLQPSQALAGRSYHAHVNASAPVSPDSSVCERYEYDYERHPSIDASRVVSSTPAPAYAESADPQLSYASSIHQYPQHPQHMRFPHSRSQPSISNYSSHLPPVLHGQPPPYEHSHDHAMESCIAYSNDDNNSNENHMHGQLVQEYRQTQLQVPEQQGYEYYWQYGTMANNNGFGFGTGVENWNAWFWPGDGYFGTGAGAGAEVGMGTEAWFAPPLDHQMYHRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU33</accession>
    <name>A0A8H5FU33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU33"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="280"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="492" mass="54809" checksum="56BA90B10E44031B" modified="2022-01-19" version="1">MRGTPRLFPFPVDDLGVQDAGLSLPRSSRSDAQVERSAELLPQGNRNPFNFESRVYEPHASSSQTGHLQPSSTTLPSVEHSPSKRSHRRSKTSLSVSATKPFPSSQVSSSQIGHDHDLSRPHSILHERSRRDSNPVFPQDVRRRHVSDDLQAQGQWEWTGADEYNRYSQEHDRHSTSHSRPHKHRRTKSDAGRHSISRHALRSVDLNRFQGPQQQHSSQFYQSPDFDYPTMSPLASSPIYLSYTYSPFSYVPTPLACPPYLPSSPTYLHPELSATSSLVYSLVLSPSTARSRLDNPNGPPSKHSRTLLASSAVSGSSRILVHLGYDHTSGDGATLVAWVKHWGPCEIHRADRSKDFTILDILTGLYRYFHIPLSSTDLNSVSPEGMESLKRARNGRIAVEAQTAAPEKTEDYDAWKHVFEKVRDLLGNLKGFGREKDVYATTSTNILRLDVLVGYTVFAGLEVTGKQHDPSVGGLRVDLDLRLASALSGPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUM8</accession>
    <name>A0A8H5FUM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000081">
        <property type="protein sequence ID" value="KAF5349378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUM8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13430" checksum="BA9AE7F8C19051C1" modified="2022-01-19" version="1">MTGAQHASTGTSVELDDTQECTHVIAFSEINRPIQTTTATTGDTSGNSTELEKAINLYDLIRVLELRSFLRLPLLYPHSHSPLCQYIHPSIPKDTVAHGEIVETDWTTHVAAHCPHDTVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV27</accession>
    <name>A0A8H5FV27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV27"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034593635" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="26"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5349782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="539" mass="59564" checksum="F484272097188D79" modified="2022-01-19" version="1">MGFGKLYKNLFSFLLLLPLAYSASLDVRIPTGTFRGFVANGNERWLGVPYALPPVGVRRFKAPVPAARSNAIVNASTFGNACPQPPSRLDAPVKEDCLFLNIFRPENTSADAALPVLLWIHGGQYTTGAASEPAWEPSELLARSVAINKPIVFVSINYRLNTFGFLASSLVAPEDLNAGLLDQQLAMQFVNENIKAFGGDPSKVTIWGQSAGGGSIQAHFIYPPPKPLFRAGIGNSAVGPFKHSPKASIFDEPDKPFGRLLTNTGCSFGRDALECLRAVPFETLLNISNTMILGTLNMQLWQPAVGPRGSLVPERASLRIEAGNFLHLPYIGGTTLNEGSTFADPLIGTGLSGRAEDEAFIDYIDHLFIDNSTITPDVYADSLRMYPANDMNLNAPFNTGDSLFDRATAWYTNAMFLSTRRLWFEHASRFQPMFGYFFTEFIPGNDPFFGVSHESEMPLLFGHIRAVASIETDFAHKWQDFYINFVNDLNPGEEWPLFTKNDGSLLQLKRNNITVIPDDFDVRKAAFFMTDRILAEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWB3</accession>
    <name>A0A8H5FWB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWB3"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="223"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5352150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1241" mass="131837" checksum="6AA8AE590566C259" modified="2022-01-19" version="1">MRALFKPFAIHAAYSPIETIVFFSIVGTLAYFHILNAIKHSSFFASQYPTTLRPSHVFLSNNEWVSVRDNLWHHVKSGNDDSILPVVLQTVEFQLDAPEDVSFGIPELANPVLEQVSTLSDSLPSALGRPCYRPFGINDSSSDCFTDTFVTPRSIYQSLAFQPTPLREDFTTVLQRLLGAGYEVETRQTETIGDMKSSKWIAYAARALVVRFWDLAKKTPSLDILLILSGYILMHSTFILLFIRSRQLGSNFWLPSAILSSSVLAALLAFPIAMFLRIPIDPVALTEALPFLVCTVGFDKPMRLARGVFGHPGVLGQPRSSPSALKPAGEIILEGLSSTYTPILRDYILEIAVLVLGANSRVGGLREVCAIAALVLGLDCLLLCTYLSSILGVMVEVRRIQSVRATSRSRASSFSSSSSPPSALVGSPTSRSPTPSNSFSSLSNKISAILGAKGSSLKSKSSKTKQENPVARLKLLLIASFLTLHALNLVAPFSGPHPSRQHSGVSVAPTRKVDVTTPVVQRVLEALAGTEEVEAGEQRDGGLVVKVNPTVRVKVVPSSALLSSVMPQTYGSTGLFSSLTGSVSLDSAASDVGTDADAHASGLGDLLNRFLNQWTLAVGDPLLSKWIVVVLALSISLNGYLLRGIAQGVVGLGAQNNRKVTRFDDAKVEDAKVEEKKVEEKKVEEKQVVPIVKAPVVPILAPAPPPVVKKEKPTFVVGSATPSTSNSESSSPTEMSAAPRPLKELIEIYEATTPARTKPEVMKLLNDEEVISLSQNGKIAAYALEKVMGNTPEGLERAVKVRRSLISRASRTQTLEFSDVPMSNYDYSRVIGACCENVVGYIPLPLGIAGPLKIDGHLFPIPMATAEGTLVASTSRGCKALNAGGGVTTVLTNDAMTRGPAIDFPNIVQAAQAKAWIDGEEGYGILKEAFESTSRFAKLRGLKTALAGRTMFVRFATATGDAMGMNMISKGTEKALEVMSVYFPEMITLALSGNYCTDKKPAAINWIEGRGKSVVAEAVIPGAVVKSVLKTTVEALCNLNTKKNLVGSAMAGSIGGFNAHAANILTAVFLATGQDPAQNVESSNCMTLMEPTNNGQDLLMTVTMPSIEVGTVGGGTVLAPQQSVLEMLGFKGAHPTHPGQNAQSLARLIASAVMAGELSLMSALAAGHLVRAHLVHNRSQANSAVGTPASSRPQTPAPQLSGNKMMFAAKGGILGAAGALTPLTTASSTASLPPYEEKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX78</accession>
    <name>A0A8H5FX78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX78"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="276" mass="30915" checksum="9C2E98AF4C529078" modified="2022-01-19" version="1">MFSTGRKDSAEYVPLATHQDGGSSEDVDPNLQNPVSGPPPKGRLSPFIIWTSAIVALLSFVNLILIPNTILHYQLSEEDLAKLPYPDLHIGFNRIDKLLHDTLPRPYIRTWPLQIARINQGIKDTVYGNSQEVFISVKDSTLMRFVVPKGSTDQLCAFGWKGPVETRKQDLTTKGDISEIEVWSIISPMVGSPGTVDNLDFDNVSWNNRPVRGELLGTMDLKNDLVNATTENFACPSQDKHLVVEFRCVRVDCQVSFSQIKDVHPNMGFELLRQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYM3</accession>
    <name>A0A8H5FYM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYM3"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF2">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5354505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="472" mass="53001" checksum="EB7DCD786546ED77" modified="2022-01-19" version="1">MPHEELNIPPITTAVLQACQKCFKDDTREALSRCSKCRSVAYCGAACQKADWKGHKVICKAMSSLDDISIYHLTDAISTDLEATNRICEENAQNETRAIQLALRRSMTVQERNLVGWQPKCYGCARTDRIIRLEKSADHASLGCCPDCRLAFYCSQEHWDAVKHFHTGPSKERDGLSQCQMNQQFRMDIRFQYSVPDAGPFMWAPERSKPIWEPLKAGDEGTTCWEEEFGKDLEMAMQGARVPVVIPFLRAASRGLSMPLTILYALQKLHGEDQVWTSKDTLVIHIMGASISKEMMSAQLFEEILHRIPNVKTLKLVLIGPEVPDSGSVEMETCPDCTRKRRKRIHAHHSMLYHDYVHRQSTKFVAPDLAIAFNSGASELATDGSGTGPGASWKETIKLLVEKKIPSVFTSFNHSEATTESQTLRDYGATLLATEDLGPRKNPWGSMHLIPEPNNITGWYGENMWFTGGFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0C5</accession>
    <name>A0A8H5G0C5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0C5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5355243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114007" checksum="36DFBE428985408C" modified="2022-01-19" version="1">MSEFGGAWKVGGCFGVTYKPTKRDTLMVSDPVAIHHILHTQGYLYPKTRESKTFTGLAFGRGVSWAADDTHVKHRKLLNPAFTTQSQKAFFPVFRRVAALLTERWKEKCQEGDVTQFQTINVNRGLVDTTLDIIGEAVFDYHFGSLDQHGKANEFSDIFHNLWAESNMFPPKPAILFAASWAFWPEWLLRLVEYLPARQFIRFREFLIHGKKLGKELVVEKAVGVEKGQSKKTRDILSILALMFLSSLVDANESADVADRLPEDEVLSQVTTLLFAGHETTACTLTWLMYELANHPEDQQRIRDEITEKRRKLVANNQKEFNATDFESMNFLNACIKEALRYHPISPWVTRESAADDVIPLSEPVISSSGAPITQFKISKHTPVLVSTCAYNRHPSVWGADADVWNPRRHLDSKLKEKQVPVGVFSNLLTFSGGYSGCIGWRFALTEMQSTVIELVENFEFAPPTDYGKIKMLRVPIGAIMAPMIDGRIEERTQMPLGDMPSKQLVWLITGTTSGFGQRLVAAALARNDLVIATARSSEKLQEVYGDKPPENLRLLQLDITAGFESIKQIMNVAAKIWDRIDVLVNNAGNGYLGFIEESGSRMIREQFETNIFGVVDVTNAVLPYMRARKQGTVVVIGSRSVWRAETPGLAMVTTGTYAASKAAIHAITESLAAELSPFNIKVLLVAPGAFRTEGIYSIPFNTSNPIPDYDSLRNVAMARYNSIPGTETGDPTKGMQVLVDVIRGEGCAEGKKWPGTLLLGEDAERDLRKKWDTFTNILKEWGDVVRTGSQILREAVADPAVSSITVLSRRALPDWLTSSIPKNDKTTTVIVEDFLKYPADLPPKLAAHDACIWALGGSSLGNSEEEYKKMTYDFLTHMVSSLGEVAKIRADKEPFRFVFVSAAGANPDKSTSKQMYGRVKREAELYLLNLPAESRIQPTILRPGYFYPEDPNIAKQTRSTAERAFSVALRPLVSNFWSSNYIPTSEIAQFALKAAQGTWGTTEQIFNNDRMRELLKNQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0J0</accession>
    <name>A0A8H5G0J0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0J0"/>
    <dbReference type="OrthoDB" id="2688364at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="463" mass="54138" checksum="92869DB0028645F3" modified="2022-01-19" version="1">MMEQTHFTSLPSDLLLVIFDWVSPLDIIHLRQTCKLLHELTVQRSVWASVYRNTSLFLPPGPHTLHPVSELERILVRAQRLDENWCLESGAPQLKTIRELTYEQDIRCMRLYRGRYLIVGFRYSFMLYDLERGSDWDQPIFQHDVEPQMGLEYRLRRHDSREGFQNDGHPEVGMYFAVFPRKKGHLRSHSIILWKIDPSQPVPISQVLSLPVEPSSVTTVVISNDYLVHWYTDDRKDRSFVYHIASKRLYHFEIPADEQQSWRPNDFIVLRDQVIAMHLHPRTKFECFAIPKQDETRTDDIRLERTHCGEWDVPIQEPQALVYRPPTSSTDEAKIVFASLMPLQRTVKLCLLEVILRQDGTISFNKIAEGNDTSSYFLSADICHRERFIRALSFEFSHVQPLQSLRLYDIDLNYQDQNGTPKIQERQLQLQSPHDLLGELAFDGYVGRICLGSENKVTVGDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G133</accession>
    <name>A0A8H5G133_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G133"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5356382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58950" checksum="3B3A3BC811C6CA6E" modified="2022-01-19" version="1">MVVHLDSNLFTVGVICLVFLVGKFVRAYHENSKLSKIPTVGPDGILTSYITLFKWISQGTELIEEGYRQNRGRVFKVPSINGWYIVAAGTRLVEDIRKASEDELSSREATYEVVHDYYTMYPDTLSDPYHAEVIRTKLTRDVGVHFDDLNEEIEDIVPKEIPLTEDWTEIHAWPKVMSIAAHTSNRFFVGLPLSRNSDFCKLNIDFAESVFRNATILLLFPKFLHPIVGRIFTGRRVAMRRIKKYLKPIIEERLRMKEQFGEDWADKPNDLIQWSMDAEELAPLSKRTSVEDLCARVLTVNFASINTTSNVGLTYLDFLLSVLLQLAAHPEFADPLRNEVESVVEREGWTKPALNQMWMLDSFVTESVRLQPTGAMVPFRKAMKDFTFSDGTTVPAGTLVTTAAWSILRDEELYPNGNEFKPFRFSELREKEEESMKHQLVTVNPEWMVFGQGKHACPGRFFASTEIKAILAHVVLHYDVKLPNDSKETPATFKKQIHTGPSLEATVMFRKRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1E2</accession>
    <name>A0A8H5G1E2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1E2"/>
    <dbReference type="OrthoDB" id="3256367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36088" checksum="A833B91F83E27F8F" modified="2022-01-19" version="1">MVSGMHSCPVELASYIFSLACTDDGATVHSLSLVSRSFNDICAFLRYDSVSIHNREQIARVSASLSKLPPHLRRIHHLYIFLAPPQARVDVNDDIELVFRILQFASPTLESLAFVYPNTVMSSTAISRLFRTPFPNLHELTVHGFYPFPNSSTMHMPRLERLHLSGNRNPYGLFHMNCLNDSLPYLTHLRVSGLLMASSFAIELECVVNVSRGVDSEQISPVPGRLPLPSKLEHIVIQPGYNPATRTSMGNMKKDEAMMKTLQDVVRCQDTGISDGVKGNLRVVLENRGEVPDMMMKEVLYRDWMSRLDGKAGCWPLECRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G604</accession>
    <name>A0A8H5G604_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004892</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G604"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="302"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5358979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="67063" checksum="D40EAE67FB20FE10" modified="2022-01-19" version="1">MAREWLSMPIQWLHGPRAPNPNSTSLHISELSEQERNLLLSKFHYYYTSDWDWGLPTIEFFCAGIGLIIVCSAIFRIRGRRARTMRSNSVTHAVPGLLDRLTAAARYTVAQQYRVPLFGWYSPPLGAIIVIAGIFTFLMGFMLSVRPYYWSNPLMGHSPPIATRTGWISLGIMPFMFAFSTKVNWVGLLTETSHEKLQVFHRWTALFMYITSLVHTFPFIVARIRDGTMEVNWRTGNFYWTGVAALVPQTWLIFMSWGIVRNRYYEFFKKMHMIAGVLFMMFLFVHVNGQLYSWDYFLATFAIYFSAFFIRNLKTLYNGFALPASLQTLPDGMLKLNVTTPARVKWAPGQHFIIRFLHLGIHAFSSHPFTVASIASRDGEQSDLELVFAAQGGITKRLKDVVAGKPSKAFKVWIDGPYGGPPVSVSQYDRVYLMAGGSGVAFTLALLRDLTQRARKGELKCTHVEFILAVKKSETLLWMEDEFAGARAHGIAIQLHVTQPGHDIKREKSVDVEDDSIDDKSMEKPIAYGRPNLPAIVYQVCRTQQGTIAIAACGPASFLYDLRNAVADCQLAIADGYGRCKDLYLHTETFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G668</accession>
    <name>A0A8H5G668_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G668"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="411"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="818"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5359068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132617" checksum="F3B4FC35F8916DED" modified="2022-01-19" version="1">MTRRVLEMIPSASSLSNNARPQSRGSQRPVSSLSYLQPGSTQSVSSLARPGSSASTFRPLSQLSHRPKSRQQRLTSAKLLPLCQRLVRNLIDASVTGEADEEDDDVRESVYNHGVEHALKTLGVEGSMKAAVTLDMEVVEKMVRGHAEKARIKSSDTLATALEENFNKLKNAPEREYDLDSEIKKSLLPNHVQFLLALSSSPDPSTLTYASLYLDELRNPRPPPESDALTWKKILEEDPYEGEHWIGVPGGLPLPGKKRHQGGEHDYGDLDLDSSPSLSPLDSDDLDLDDTESDVESGPVPEETQAPTGTGAEKFSVEGDWRPLHTTHAYRKEVESLKKRQYWREDWRMDPDITVQGRGTFNIGDASTLGPTVQRVLPQDEPSNIAASTDTSLPFELVVSAERYIYEQDAVREILMALQGRNNIMLQLKAGQFVTTRNTPRLLHLSLASQSSILDGLGKSCTIIQKLRNFTAFIMQESAISTKASTSSARYRTAGRMTHTLEAFADAIDMELRDLYSWCAQREEVWLRALGGSQDNPDAGDFSDSGLVVSLLGTASTFQDRFEDSFPVLLDVVHQVVLESESGHWSIPVRPPSVTTASLLDTLFFTFQQRLERGDNVTADAIMRVFVRSAEPIWGMLGKWLGKGFDLNGERLEDEFFIEANGIGVDMGVLGLLDPDFWADGYGLRDDDAGSSDPADVDEQSRSKGVPSFLQHVAIPVLQSGKAVGLLRALDKDVGHLSEMHIFRNWHWDSFQSLVAGSGNDIPEPHRATEGQRNTGELFSVSLDRLERLIYEKVEPYSLAAGGLLADVVVEECNFWPHLHAIENLYLMRKGDVISDFADVLFAKMDTRQNWSDFHFLNTAFNDVVESSINAKPWIQLSLVRLFYRGDRLKEQSIARTVKAIDGLFLEYAVPFPLTYIFTRQNLQVYDEIFGFLLQIRRAKNVLEKILVRGEDRKSGRGAGLKAFYAMRSRLSWFINTLLNFLTTYIIHIQLSKFHDDLKDTNALSFDQMIELHNDHLGKIQGRCLLQTKTSSLQRAILSILDMALSFSDAFVMFAGDTSMTHDISSRSLVLSKRHQSRRHRRRKRNVVGFAQSINWDDDSSDSDEQEVDLEGNSIYKQGASSFFSSVGGGTSFESEGLGPFDRISKMSAELDGLVKFVRKGVETLAGGTGEAASAFGVLAFLLEDWDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G861</accession>
    <name>A0A8H5G861_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G861"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="66"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5360056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="42027" checksum="416D8AA9C9FA24B5" modified="2022-01-19" version="1">MAASVPFRFPIQDEQDFNDSEKVYEYLQDRRVVGYEPLIQPALLRHEIVSTPNSHRTIASARYSAAQVLSGQDDRVLVIVGPCSIHSPEQAIEYARLLKAKIPSWPNLLIIMRAYFEVTIAPKPRTTVGWKGLINDPEIDGTFQINKGLRTARKLLCDLTDLGVPVGSELLDTISPQYISDLISWGAIGARTTESQLHRELASGVSFPIGFKNAIDAMLSASHPHAFMGVTEQGLASIVKTRGNQDVHVILRGGTKGPNFKAEDVKSAKEVIEKKMGGTRASIMIDCSHGNSQKKHTNQPLVIADICTQLEAGERSITGVMIESNINEGRQDVPGGGAACLKHGVSITDACVEFETTTVEMLDRLNKAVGVRRDEVASSSSAKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAG3</accession>
    <name>A0A8H5GAG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAG3"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF42">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="116"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="392" mass="44047" checksum="54445652B2E578FE" modified="2022-01-19" version="1">MNSFNLSFFPSPPLRTVLTVCAASYAAFQVVTILASLVPLMRTNPSPVARRLIKTSKVKTKPLPRGVRRIYAGKPLNGQDCRIIEDDDESKWEYKIEILTNAGNNGPQNSPHLAPLVLLHGGMGSARCYDRWMEYLAAQGAREVFSISLRGHGNSTRPPYFTHLGKGAFAEDLHTALVAISHYLNASPDSTSERPHPVLIGHSAGGGLSQYYCSSPSFNPRLSALILIAPFPPSGGAPTFRNWVAFDRWFSLRFIWEGCDPMSAFGRPDLVKRAFFHDRKPLTRDDVHGEKGEESVQEFFEQMNPEENGAWSMSMMFKFADVARVKASVHDKVHLITASHDRLMTPDIMSRVQKMYECEMDVVHDSGHHIMFDTHWEDGLRFLEARLTKWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAS8</accession>
    <name>A0A8H5GAS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAS8"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5361469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56372" checksum="128B0E112928D02D" modified="2022-01-19" version="1">MSVITTPSILGASDDEREDSFPEMASTPAMRTPLTDVPEHGPFTPTTPDYPNSPYFTSTAARSSATLGGPTYAHSSSSGGGGSQSNLGTTSRRSGSSRKPSRNSEPDNRDSSSSSSGARRTTPSASSNSSHSTMKDEHGHRERKDRDREGHPTKSPSVRHMGSGNLAPSSPRIRTTPRLPHDKDAEPAPSTIMYWSRAPVFGTCPARTMRGHTVTLVDTTAWVFGGCDDKETSRDIYCFDVETMQWTHPETVGDIPPPSRAHTATLVDRKIYIFGGGQSSSYSDAVYILDTTTRRWTRPDIQGEIPAPRRAHTAVYYGGKIWVFGGGNGMMALNDVWALNVAKMEWERVRPRGMLDRHGRENFPTPRGYHTANLVGNMMIVVGGSDGKDCFAEVWLLNLDSLEWTIIELPESYKRLSHTSTQVGSYLFIQGGHNGAEYVNDMKFFNLVNLQYEHRQVLGKFPTPRGYHVSILADSRLFFFGGYNGASAYDDVHIVDLAGAAYLPQVTSFTIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GBE9</accession>
    <name>A0A8H5GBE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase II subunit RPB1</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA-directed RNA polymerase II subunit rpb1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_007275</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GBE9"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="15">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5361635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="16969" checksum="5E5FAB049CB9FA89" modified="2022-01-19" version="1">MLGHQFAFSTAPIRKVKEVQFGILSPEEIKAYSVAKIEHPEVMDEATHKPKMGGLMDPRMGTIDRNFKCQTCGEGMAECPGHFGHIELARPVFHPGFIIKVKKILECICVNCGKLKADIVSHCLPFLYSFRSPLPNFLGALATYHGEPQTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGK9</accession>
    <name>A0A8H5GGK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGK9"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="1">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="46475" checksum="56F8FC4C81610B60" modified="2022-01-19" version="1">MSWLYRNPYYSNSNPPYSSDLYSGYYVHPSPYQQAQAEPVFRPPYHSPYDSSNLYYSSDPYSGYHPHPPSQIPEYDAPPERLDEAAPTFQTTPRVREAFEAIQSLQKEFASLKQFFVWPTKLDYQLGNGRVVSIPTSLETLSASEALSALESQDLDLTTIQQISKPELAHTPSNMPVREYAESLTKLILLLDGVESFREKKVIEKRKAVVRSVMDEVDRVEEFCSCKDLWVRCTALFDASPERLEEAAPTSQTILRIRYIQTFQDKLASLKQSFDWPTKLDYQLGNGRVVSIPTSLETLSASKPLSALKSQDLDLATIQRISMPKLAPTDSNTPVCEYANSLNLLLTELERVESYGEKKVREERSAAFRSVADEAARVEEFCKDLWVMWTALLQSNSATITKGASGSSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIK4</accession>
    <name>A0A8H5GIK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="2098"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="2512"/>
            <end position="2540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1804"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2528"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2585"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1565"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1682"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2493"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1824"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1862"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1923"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="2007"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="2063"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2543"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2613"/>
            <end position="2631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2644" mass="287881" checksum="F1A57C23E6082490" modified="2022-01-19" version="1">MPLSPSHNLRIGVDVGGTNTDAVLLDPFASALQNHGILAYHKSPTTSNPSDGIKNAILSLLRDVDPKAIASVSIGTTQFINSIIEKDQSRLAPVATLRLSGPFSRSVPPGLDWPVDLREIICAYCAFLDGGLEIDGNIIRDVSEEQVKTECERIKAMGIRSIVVNGVFSPADVMGQRQEERVGEWVKKYYSEAEVVLSKEVANLGFIERENAAILNASILAFARHTISSFQSAIRSLDLACPVFLTQNDGTILQASDAARLPIRTFNSGPTNSMCGSQFLMKHSVSSAKRESILVVDIGGTTTDVGMLLPSGLPRQAASVTNIAGIRMNFSCPDVKSIGLGGGSIIRIKDPAQPTLTIGPDSVGHRITEHAHVFGGDVPTTTDYSLVTQYIQGNSVTGIGQVELAVESATKVASSSGGVSDLVSAYQSQLRSMLEGIIDRMKTSAEDVPVLLVGGGAILVTPDQNGTLKLKGASRVLKPEYAGVANAIGAAIARVSGTVDTVVSTEGRATKAILDEISALAIDRAVQAGAVLDSVEIAEMDLIPIQYVANKARVVVKAIGDFDFSRVPETSHGLPIGTMTSSESSTQYSLKRSKLSTANDHLAVLSTPTAISSYTPTVVISPGRPASSPNSCDYEWHLTTADLEWISTGCYILGTGGGGTPYPHFVHLRNMMRPVTGEVGANVRVVEPGWLKDDSVVACGGGKGSPTVSVEKLPGNEMMESQTIVYNYLGIKPDAVIDLEIGGGNGLQGLILGASTNMDIPTVDGDWMGRAYPVAWQITPVVFGGDGALFVPTAISDGNGNSLLMLTGTSEKQIERAFRAALSEMGSHVACAKGPFPGSKTKAYAVQNTISLAWRIGRAVALCRARNDIDNVAEAIIGEVGGPEAAKVLFKGKITGVERKTVKGHVYGEVLIAAADISGSGISESEGFKGQMKIPFKNENILAMTVHEDGTQELAATVPDLICVCDASSGEAIGTPEYRYGLLVFVLGITASDKWTSSRRGIEVGGPKAFGWDDVEYKPLGKSTSHCISVYNYLLIYTSPFWFLLLLLLLLLAPAAHDGEGTGFDACAVHMDSLFGRKKAKGRQSSISGTADLNESSVPYDRLAPSPRSPIPVGTVSQIRGGGFISAPITNPTLTANGTELNKFAIQRSRAEREKAYDQYRPPSPSLSSDSSTLYTDSQPSSSQTKLSRARRSEASSSSSTSRSPSMSDFGQIPNGSNSSNTSYASATVRPTSTMTTRSERSEGNRVSKYAHSFSSEVGSHLSQFYHPHRITQHGTEEFTFPRPETDEEVEALFENVRRTRDLGDLPNLSTEQKWRIVYNDWQMRWMEEKARDDQTRKLNESGQPVAIMLESPEWYVKKFLDKTITPKQAGSLLVSLRSKELGWFKQFIAIQGTSVLAQTLNHLSRKGSSRRETDIQLEYEVAKCLKQILNNHSATNEALTHNLIVTQVASSLNSPHIPTRKLLLELLSFLTYWNDGQAQPLVISALESLSSSNNENGGPYDYCDEVKKTGGVDTNLNDYALANLILIRGLLEFVDDLDLRLHHRSQMESAGLSRIIVLCQSYNVANIDKQIKALLASLEEDEQKLRERLDQEILRDLNNPQDVYNAIFARIQDTKAKDHFLSMMQHLLLIREEGAPMVHYYQFLDSLVTDVVLDKKLAGAEQRFGHSVERIIAQFNEADRLQVVEDEAQRVRADALRLRLEKETLEEELAQGGDGLVGQLKERLAHVEQKLSISRENTARLQGQVETQKAGYEEQIAQLEAQIMELFRMLKELGTGVETILDNGAMDRKSLVQTLEKHFQRTQTINILEGRQGGSRRRKKDGFDDDDDDDDEEDVDATPGKSSLRRGPKPNGPVPRKPSQRYESQTDGRSSQFMDADEADANEQIQQQLSAGVTAYPSRDGSIANSRSIRGHSRRPPGSPLASKTSELLSPQAGNAYVFPEDEGDRHNKEDSTTPSNAAEPGSFAEALAKHLQSKGRPIPDKDSPLPSPPLPEEQSTSAASAAPPSQLPPPPPPPPPPPPPPPPPPPGSARVGGPPPPPPPPPPPPPPGFKAIMPTSTSSAPIPPPPPPPSGMSSGSSSVRASMLGSNLNAVFSPRKDLPLTTATKLKQLQWDKLPQTQVSATLWKDEDSKKEQEMLKKLQIDGVWSEMEEDFKAKQLVINLMARQKRAELKSVLDTETKKRVEILIQGVKKLEPEEIASRIQQFDQTLCTQVFLSELKRVLPSPEQVGKLNVYRNSDRDELLELHPADRLMVKLIQIERLGPRIEGMLYQCAFEERWSLLDEGARKLSEAGQALIDAKSFKELLNLILLVGNYMNGTGIKGGAFGFRVSSVNKLVDTKSVNNTTLLHFLERTVAKHFPHMEEFLEELLKPAEAYRVNLQELRKGLGDLRDGLKQIRNELAEHFADIDQNDEYGKKMWAFVKKANSRVEDLVDDVNLADTTFTEVIKYYGEEDKNMSSTEFFGIFKTFVTSYKKCKADNQTFAEERLATEKRKQAAEELRANREKAMEAASENADVLDSLLEKLRNGDTVSRKTRRRGGAGASTTSASEARAAVPASLQLDNNASGDTADIARDMLAQLQSNGFVAAQPSPTLPPPSATQRRRRKRIEVTSEDLQGQDDVSSLQSPTQEELGSDSGVSDDIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJS6</accession>
    <name>A0A8H5GJS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJS6"/>
    <dbReference type="OrthoDB" id="2969033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="459"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5366424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="695" mass="77150" checksum="4BEAD20D39EF2D5A" modified="2022-01-19" version="1">MSSLYLLLQHYFQLPQAVVHSVVLPLDLFNNVKVVASPSQITVDGIKLWHTSSTPLDQVPEDIQFQFAVKESLKEISTTSKSGLPCTDEDCRTAKGKPRTRSQCCPNQRCASCCRRAFGGCTQHPINGQRSTALASDLSPSPSATASTSEISEPISESESNSAGSQTVIEPRRFARPLTEGWGQALASQHKRYETTRQLAEAETLANQEPHHVQVSSKHPKTLVVADQPLLIEVLSDPKSFVTVYAPKSHKWFSQEVTLPITHDGPCVLLRSYNLEDSDCLNLELEVVRLFGDSHSVLQRSASSALMPMSGSSSSGTPKALDPSTSSRRTFPRKYVVDMVAGLKKLDGLKGVVALKEAFIGAFEGCTFSSSTVYNALKVFRDARKLGLLDKYQAAARTDDGLWSKLVKETKESEGDGKLKSLKKEDSGTLESSTEESQSDDSDDGPDYQVWTVRISHIDYNQFVEYDEEQCLGAHYLLETDGIPLVLTFDNPTCGGIKRVCLGLAALNGKKTPLAVKFFGYKQAPNWWKICSPSLYLTLFTEATRLYQLREAQRAFVAKAEQVGMAITAFEVVETYLVELKTKPTEAEVVMIAQPWIYGQAVNPEELENDETFSAFTHFCYQYFNNERIDVHFQAIRDSGRIYIYDSLSHLILDRSSGKCNFIRSQGRIGIMEHVQKHTCRGKCEKLGLPSMVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJU5</accession>
    <name>A0A8H5GJU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJU5"/>
    <dbReference type="OrthoDB" id="3269400at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="119" mass="14031" checksum="BC3C2F7E02C07930" modified="2022-01-19" version="1">MARCNSLYFEGEGIVKTMFVDSDSDLNTRQLRSWNVLSRADTSRLLYSIECIQQQVDAYDEELQNLLDRVRVLEQQKDYAVKSLRRKRSLLAPIRRLPIELLEEIFALYLHSYGKDVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKN8</accession>
    <name>A0A8H5GKN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate synthase</fullName>
                <shortName evidence="23">DHQS</shortName>
                <ecNumber evidence="23">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="23">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="23">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="23">EPSP synthase</shortName>
                <shortName evidence="23">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate kinase</fullName>
                <shortName evidence="23">SK</shortName>
                <ecNumber evidence="23">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="23">3-dehydroquinase</shortName>
                <ecNumber evidence="23">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="23">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="30" type="ORF">D9758_008997</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22 23 24">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 23 24">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23 24">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23 24">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23 24">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="24">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="23"/>
    <dbReference type="EC" id="2.5.1.19" evidence="23"/>
    <dbReference type="EC" id="2.7.1.71" evidence="23"/>
    <dbReference type="EC" id="4.2.1.10" evidence="23"/>
    <dbReference type="EC" id="1.1.1.25" evidence="23"/>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 23 24" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17 23 24" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 23 24" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="18 23 24" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 23" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 23" id="KW-0521">NADP</keyword>
    <keyword evidence="11 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 23 24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 23 24" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="27">
        <location>
            <begin position="82"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="29">
        <location>
            <begin position="195"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="25">
        <location>
            <begin position="419"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="28">
        <location>
            <begin position="1326"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="26">
        <location>
            <begin position="1445"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="23">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="23">
        <location>
            <begin position="1321"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="23">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="23">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="23">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="23">
        <location>
            <position position="1210"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="23">
        <location>
            <position position="1238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="886"/>
            <end position="893"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAF5366551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1611" mass="174303" checksum="39016E436E350118" modified="2022-01-19" version="1">MATTTDVQKVSILGKESIHCGFHLVPHVVQTIVTELPSSTYVLITDSNIAKFHLAAFEEQFDVSLSSLANGTHAKPRFITNIIPPGEPSKSRDGKAAIEDFLLLNKCTRDTVILALGGGVIGDLVGFVAATFMRGVRFVQIPTTLLAMVDSSVGGKTAIDTPHGKNLIGAFWQPEFIFIDAAMLETLPPREFSNGMAEVIKTAAIRNEAEFGSLESRSAEIFAAIQTPSTGFAGRTRKTRSASQELLLSVIVGSITVKSQIVTLDPLETGLRNLVNFGHTIGHAIEALLTPIILHGECVSIGMILEAEISRHMGILNQVGVGRLTRCLKAYNLPVSITDPRIANLPSAKLLSVDRLLDIMKIDKKNSGDKKKIVILSRIGDTYEQRATVVPDATIAKILSDSVTVIPGVPSHSPVTMVTPGSKSISNRALVLAALGKGTCKLKNLLHSDDTQVMMAALLELKGAQFEWEDAGETLVVHGGAGSLAVPSMGKELYLGNAGTAARFLTTVCTLVQRSPSDEADTTVITGNARMKQRPIGPLVTALAANGGKIAYLESEGCLPLSIQPNGLKGGVIQLAASISSQYVSSVLLCAPYAAEPVTLELIGGQVISQPYIDMTIVMMKSFGIEVVRRAEEGTGKLLDIYDIPKGCYVNPPEYNIESDASSATYPLAIAAITGTSCTIQNIGSSSLQGDARFAKEVLEPMGCKVTQTETETTVQGPPVGQLKAVPHLDMEVMTDAFLTATVLGAVANGKTTITGIANQRVKECNRIRAMIDELAKFGVATNELDDGLEVTGSPISQLKQGVTVHCYDDHRVAMAFSVLASAVPNTVMDEKRCVEKTWPNWWDDLQNKIGLETKGVELAGPTDSVSTTSVDSDSVKNTASIILIGMRGSGKTFIGELAASALEWNSLDADVYFETKLNIGVRQFVNEKGWPAFRETETELLKELLTEKKEGYVLSLGGGIVETPAARELLKEYSKKHGSVVHIVRNMDEVVEYLGVEGSRPAYGESITSVFDRREPWFRECCSHRFINHVEAFADGKIVIDPTVTRRGIREEVSRFFGHITGLQPNLAPNVAWGCRSYFLSLTYPDITPALPKIEELSIGVDAVEVRVDLLRSSKDIEPQGSHIPSQAYVADQIAALRRVTSLPIVYTVRTVSQGGAFPDSVQEEAKELLDLALRLGIEYIDVEISLPDAWIRELIARKGASKIIASWHDWSGKMKWNGPEVQEKYDAADKLGDIIKVVSKANSSQDNFDLQQFVTRMNSRPNAKPFLAINMGTEGQLSRILNTTFTPVSHPLLPSKAAPGQLSFGEIQHALHLIGQMPSKRFYLFGNPISHSLSPTLHNTAFKTLGLPHTYELLETEAVDEMIKATVVAPEFGGASVTIPHKLNIIPVLDRLSPSAEAMGAVNTIVPVESADGKGRILLGDNTDWLGIRGSISARIAPGCIHSALIIGAGGTARAAIYALNNLHAKTIYLFNRTHAKALELVEAFPGVNVQVVEELGKWPGGVVPPNVIVSAVPASETSLSREPHRLHFPAELFAYRDGPAIVVDMAYKPVETPLLKLAKSTAHNWETAQGVEVLLQQGYAQFELWNKRRCPQRVVSNTVWEEYNRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLL2</accession>
    <name>A0A8H5GLL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLL2"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="39476" checksum="463D37BE6516AD4B" modified="2022-01-19" version="1">MAETDSNALIFLLFVPLAWSLLLWMIISKPAIVFHASQIFFNFLAMACFASVAAFQAKWDVGPSGLSGFTLFITIAGMLFSAFMLIVPVLYEKYDKFIRLARALKEVRVGFILTGMGTGISLLIAFIVTISAWTQPGCKDPEKDPHADKGDDFKNGLSGWCNTKKAAAIFLWLAFVFWGASFVLLVINWRQGKLLSGPRDPPFQHPIGMDDGEEDDEESSYHHIPPVTNAAAPVASTATSNPFGDTSNRYSSGSSYSPGGYTPAASSTGYAPSRPSMDAYGAFSDPAPSGYGAGGRGTSPHRVSAAPPTIPEPDFGPGVESGPGVSRTMQYADPYAAVRSSLAGGQQGAAGQPSQQQYGGPPSYDYQGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMV4</accession>
    <name>A0A8H5GMV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMV4"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="140"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="310" mass="34899" checksum="3432D6940A4B792F" modified="2022-01-19" version="1">MPLTKRRAFWGTGGPISCSLPLTSTDFPSEPTSDIDMFSTISESEDDENQVKITQTSKKTPETDAEKLTCQTYPQYIKSLNDHTVATMARTEIPAHMLPRDYIEGLSCAFLKKLCYQLCLVCWQVTKRTQCPKPLQLEFACAVHKKQDVFMNVGTGFGKTLAMILLLLLADGSFIVIIISPLKRLQASQADALREKYGLCAVIVNEDSPKDDAYWKTHAYDFRLKRLGSADVFISMPEQFFVAKEGYPTIFSKFVCKSVFNQRIGLIAIDEAHFVHLYGLEHYGIHPFRPAYGDLGVSRIFLVQTFPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN19</accession>
    <name>A0A8H5GN19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN19"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="212"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="666"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="770" mass="85050" checksum="8D756CDFF9852DB3" modified="2022-01-19" version="1">MSQLSGNNGGGTPHSKAREARRGTKKIHADSGRNSGTENQVIHRRAHPGSKSPQPLRGFKETLESKTTQTKTQIYQPASLYWYQGSKIPIIRGKSYPGESIASERLLSLAQKLKVTIRQGISTDQPLIEQDSTFSQISENGQHSVHNNMFHKASNFQMDGATFNTAGGNISHTVNNYYNEYEPELLKVLDKLNPATKALHDVGARSTCIEGTRTEILQSIISWAENTSPDAPAGYWMCGMAGTGKSTIAKSICLKLEEKGLLAGAFFCSRQIEECKDYHRVIPTVAYQLAQYSRDYAEAIRKVLNLEPSIALKEPDNQLKKVLTKLWKGAPSSHTLVIVIDALDECENISWVLKHLIPAIKNQEFPGLKFFLTSRPEQHIKDYFDVDEIQQEEQTLQHFYLHNVQKSIVKDDISIFLQQGLGQMSISQDKMDILLERSGVLFIYAATIIKYITGGGLRAQARVANIIDLKRTPDKVETQVLDDLYSQILEEVLSSSKLSPTEHQQSLRIIYTVITTATPVSCQIISELLELALEDVQATIIDLQSVLYINQSNQAVYGFHASFADYMISETRAKNLYCNSISHHSLLAKQLRIWDVLTGDTIGKPFQVVEMVMSVAFSPDGARIAAASGDVTILNFSPDGTRIVSASSTTVMICDANTGAAIGQYYRGHQGYINSVVFSPDGSKIISGSDDQTVRIWDSSVQSVIYEPGQGHQERVYSVAFSPDGARIVSGSSDKAIRIWDASTGNAIGQPLLGHTNEVNSVALNCVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNW4</accession>
    <name>A0A8H5GNW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNW4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25099" checksum="F1932156DF4C99E0" modified="2022-01-19" version="1">MGRVLLKVIILGDSGVGKTSLMNQYVNKRFSNQYKATIGADFLTKEVMVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNSAKSFETLDSWRDEFLIQASPHDPENFPFVVLGNKIDVEENKRQVTQKRAMAWCQSKGNIPYFETSAKEAINVEQAFQTVAKNALTQEAEEQLSEFIPPTLDLSSRSDNRSRYVDYPDPIQLDSESSQSYGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP42</accession>
    <name>A0A8H5GP42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP42"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="868" mass="94457" checksum="0E97C8B878D29173" modified="2022-01-19" version="1">MPFICKKTFKRPQDLKKHEKIHTEEHHAQHKHSKAITVADPAYSTRVRGEPTKGDAARSKTSPSASNLRVPVPRSQSHSSSSSDGSHFGLLPTPSPELVPAPPHHHHPHSRSHHRSDDLYMQNVPAWEVLHSEPVSAGSKRSHDDYSVDDFFTDMKKRRVNPAYDSRMAERLNYLYSNSVPAGGQTQFNPRSVSLDIRTPEELAAVNEFLLTLGRDVSSTMRPPSHSHSHGHSQSMSSFSPDAYFDAATLTQMGLGGMPGMPSADHFAAYGGPSPGSYTSPPSGGNYSRHSHSGYSSSMYPSVSDHSPMSHHPDIYAYQLDSASYSYDYADEHEPGDTAAAFDYLRAPRGPGPVVGLMPQDYMGKDMRPIVPLKSIPIESSERGTPAKLSASSETPKKSLSPLPSILESTSASSSLYPLLTSGDAQYKLPPLSAMYRSSSAQPESPPSRESSATPASSATVSPDHSLTSSPSVQPTTLPSLRSIASISSISSSTRTGESDELANEVEKVELASSPVPSPLPAPRKFFDVVEKRNIPLEERTKHAELIKDLLLAINEDFRKKFKYEPSAGIKNLKVDGPSAMDVDEKPYPSLYLLMFILSNELRPGPGFDLRLWSSLTEGPPKIGNECLSMIYSFPAKAYCDSSCHDHASVHGSSMAPIEQDTAFNVLLTGFEGTPEEEHPSWLAVAPLHNVVATLDPEPVLPDAQATAPNGQNQGSGPTQERLIKISSLKIPMDYDAVLELIPRLHLRPPQLPSSVQQDEFFPVPPNKGYDFIFHIGAAGRGPLRMERMGHKLAYYMKDAHGKLAPTVRAPEPEFLGRPEPDVSIGESFQVGVGQLGFDMVETAGAGDTFTARPNRGFGVGYEKFSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQX0</accession>
    <name>A0A8H5GQX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQX0"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="380"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="797" mass="89430" checksum="A11A3EEEE9E39030" modified="2022-01-19" version="1">MDLARLLSMMNNLEVDSGDESEDMPPRLSPDLPSDQLRSRMEELKKWHKRQNDLPPCAAPPSNRALIQSQRLRSRSEQESGQIWQTFVGSPKNHSSKPLEELTTVSISSMFLHKVHKGQYLLCRIVAPFVRLLASQTVVEDPSGAVVDLSIYNFPATGPGTLHKKIDSLFPVGTIMAIREPMFKLGTQGGNPFIRVDSISDIVILDEHDSICSNVNWGFPLNSPLPSTSVDNLKEIGNKHFQRGDWLLAVFAYSRGLRLDKDAFLLRLNRAEAYLRLSYYSAALFDAETVMSSNLIDSKSRWKALWRAAKALYFQGNYSAARERFEESRKFEGDVDESKEWFQRICQREEELKHGRFDWARIFRESVKAPHIQHIAEFRGPVEVRSLPDRGGGRGVIATAAIEVGQILVVGKPFASVYPSDLPGKERLLSFNLVTGTVDDACHTVLISKVMEQLWGNPESHGALFNLYAGAEYSSPAELPESHSFSSSGIQFPFKSAVDIDVMRLEAIVSCNAFSPIPIEASLHLGGAERLSQQTETPSALYLFASMFNHSCLPNAMWFCFGDVMVISAARTIAEGEEIYIPYVTPSGSFKERQDGLRKHLPDECRCELCAQDRADGVSNCQRREQLMEKIKSASTTQQYRRLLTQIEETYSSSRGNIRPELFFSKHGLGEMLRSNLKQSHAQLSKSTFRSRMKETIELDLAALKNIGVAVQDQPSGLPISTDCFPSFLSRESLAAYYLSIAVNYLNLEDNSRAVSWVKAAEWVVRAGFGGDKSFFYLLLGKLLDKMKIRDFVDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR53</accession>
    <name>A0A8H5GR53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR53"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="260" mass="28854" checksum="2F898372FFF56A45" modified="2022-01-19" version="1">MSCPDCFKGAVLDGEPTGSIDSSTGAYFAAGPEGNTSRAVLLFTDIFGLGLKNPRILADNLAKHLECDVWVPDFFLGKAPVSPGYMKMPERPGQKISKLRFIWSILPRLPGLIRQRPSVVDLRFIEKLKSEKKYTRLGAVGYCFGGSMCVRFGGSGLLDSIVICHPGNFSQKDLDAISIPCSWACAEEDFTFSPETRANTEKCLKARQGKVNFVDYEFKDYKGTVHGFAARPNLEIPEVKEGFEQAFEQTVNWFDKTMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRR2</accession>
    <name>A0A8H5GRR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRR2"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="88194" checksum="743C804BA9BF9787" modified="2022-01-19" version="1">MPGPLPAAVHALHGHSRPGDVQQPNKKHSYIVRLSMEALSALDTYPNQPEMEFQFGDNPGFFIGDSFFPVHQQKEEICHDLYLRMATAAKPNVPLKLYANVTGKLTVPERELDKSLQDRIRKSTADAASQRSAAKTKFIDSPADLPAASTGKKKKEASMFRKPVNPKIPDPSKASRPLPLPSSLPPRPQPSLSSTSQSSQRPSSDPHLRNRLVHFLAVGERTSDETIKAVAGADAGADLKGSIFQLLEEVAEQLPQNGSKRMWRLKPKTWMEVRPYEWPRLSDVDRTRMAREARMALKALNIPETDPAWAHVKYRATGPPDGTTRTDSPIPRPSPLTNEAAPAPVPKKGVSSKDAKEKKARVKNDTKEIMMKDESKPRVSEKVVPPEKVNRSNSNSSSVSSSNAASVSGDSRLSPTVTTARKPGSGYKLTKSTDVSRSRSPMPQAASSSKDDVRKKDAGRRTDGKATPNLAHRQAARDVEVKMRDDTRRSGEVKGRRDVAGETYATQSHRVKQLKEEDKLEPRRKEKAVEKPRAQDTNHRLDASLKRKKDAHEDDDYQESSNRTSGQKKRKTLDERDRASLASSSSRDRPLHKPSAVDNSRVSNIEVVAARKPPKELSPLPAAPLPKIKKGPSPVPPIPIASSVSSSSTSSRNSNAKASGKSRRRSPIYTSSEDEGEITSSNSRSTPLSRPTPNVTVNDRHSHSRNGALPEDLPRDSASLRARYTEEYVEYLKPFQMALDQKSKIQRLLKNFPDGSDGSVTDDSGLELMDAESLSRIVGESKKHWQELQNIQKAYENLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS86</accession>
    <name>A0A8H5GS86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_001049</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS86"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="50"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5370106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="705" mass="76712" checksum="4AE0FFF1AFD275E9" modified="2022-01-19" version="1">MSPGSRFRRSSSDDVSKKPKLTRSPPSPQADKHRPREPHPVPSGNPASQYTLLEKLGTGSFGTVYKAMHNETKQIVAIKQIDLEDSDDDISEIQQEIASLAQCDSEYVTRYYGSFVVQYKLWIVMEYLAGGSCLDLLKPGVFSEAHIAVICRELLLGLDYLHSEGTIHRDIKAANVLLSSSGKVKLADFGVAAQLTSTLRHTFVGTPFWMAPEVIRQAGYDSKADMWSLGITAIEMAKGEPPLAEYHPMRVLFLIPKAKPPVLDGPFSPAFKDFVSLCLTKDPNARPSANELLQHRFIRGARKTSYLTELIERYQDFRARSPQKGGPQINQATVRSNMSWDTTGSMRSDWNFDTIKTSSVMGTFRSIAKDLPLASPTEEPEDDDEAFGFVDRGSVDSAAATRGSDPIVEGGLGSNPGASHSTVIIKEPLFEEPEMDVETMLAESEAVSGSGDAVDNAPPPAYNSGSMKGTRRSSYAARHSVNGAGTVVREADIGSGVDTIRPVKKVDAAGSLRLSSEHVGSLRRDSNGSTSSPALSPTTSAKHRRAASEMGKAGASMVNEVVLPIIDKSIRDDMDARELEALSMLSRGFADLKDANPELAYSVILDILSGLNDNTGVRQYIQTSRGLFPHKRIIRKSEMTAKGLVVTEVQEEITGLPISDTASELSSSPSASSSKNEEPSRRSPIAELLYMRWLEGLKLKWPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT55</accession>
    <name>A0A8H5GT55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT55"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29362" checksum="2EB28ED83E01885A" modified="2022-01-19" version="1">MVTIRLVTFDVLHTLITPRHPVHVQYSLAFAPYLGRLDPQDIKNSFKKGWRTISESSHIINSVAALKALQQERPAYAYENGAASERWWSEVIRRTAVGAGANPSAIDGSLDKIVPTLMRSFSSREGYAAFEDALPTIRQLHEKKVFTAVVSNSDSRSRLVLKDLEFPENVTPIVLSEEEGVEKPSRELFHRALKRVNEIHGLDIQEDECLHVGDELECDYEGAVKAGMQGLLLRRPGAEEDEVELKNVRTIQSLKQVVEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUG8</accession>
    <name>A0A8H5GUG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUG8"/>
    <dbReference type="OrthoDB" id="10602359at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="324" mass="36064" checksum="CEB60F85D57B20CC" modified="2022-01-19" version="1">MASRESSTRSRRPPPGTLFNPNSSNPPSRSNTTSTKRHNSTRSTSTANRNQSPPKSKPSSPPLPAANGDVSRENSRNLRPSNSTRHHSGQRSAIPNPQQQSDRDRRPTRRSPERRPSTRHNRDGTANGTSSRNPDTSAKPLPRVRLEDPPSGSQGLERKDTAASARRETDLNRSGSLSRNDSGRSSREKDRDLARSGSTRRRDVQTSANATKANTQPPRQDSSSPPKAYTPPNPLSNPYYKPFTPFKPFDQERPRVKYADGYERPVNEHGQFLDRDAEKLVPMNTGSTVAGWVMVPDRGSVMVCSRCKEPVNPFRPKKSHRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXF8</accession>
    <name>A0A8H5GXF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXF8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="46960" checksum="9E09B00BC1970D6A" modified="2022-01-19" version="1">MKSIKNITTTVYGHPLPGSGRRCDACSDRHVKCHKKLPDEDCRWCRNNGKSCTYWRLKERKSRKQGQWQGMSVFQVSKSCASGQVKTRGGAKDNKVYLMTPEGRDDPTLISLGEETTEKYVHIIDLKGPRKPVRKKPRKPVSFSSSIHLFSVNPMRNMIPKSPLSRISRTTTQNSFQSSSYPYDEVDDYYRSPYPERQASTYHTAPTPPEIESTQQVVIQPPTVTQIGRPDPESDTDSSDSSHSQSSTVSSSLTMAEPVRIFSPVPRKPYVDISHLHLLAGGYGASTEHANENHVNHESDAPFNGVAMTPFHSRPPRPLRYCPASFGLQLKELQSLIYLDSATSRPFSDFAMDVDLAYPPGLPDPSAGLGVPMMGLSMLSGPVLNHTMNYYSQYLQHETAGIAIEGVDLNLHYSYDSFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ61</accession>
    <name>A0A8H5GZ61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ61"/>
    <dbReference type="OrthoDB" id="3251871at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48262" checksum="522CC2E1D9D8C2EB" modified="2022-01-19" version="1">MNPLTRRTPTTADFNFAGNLGLYSTIPGTCLCFLVLVFYGITALNRKGRKHLDRVSFRLLVYSLVFNILYGISFAVTAAQTGPGSLCTFGAFAVNFTLTFAIFFTTCIAINLELVLVHRLSGKMMEKYYIIGTTILGIVLNVPPYGLHQFGFHEASGVCWYKNPDDKLRLHWLIGTQSFWMAFAAFIEILNTRYLQKASTPGHTHSLASSSGAGTTRSGTSATRTTSFWSGTSSTQTAADDVSRKYRGVIIRIALYPIASLLINSPTIALDIYSVVVPLTNDLDFRLLVVDLILYGLRTLLYAILAFGDPSFIRAVKEIRGKPTSRRSTGDTGHTVSHARFAGGRRQADSAITTMGGGPLAVNVELQKTTFADDYSMATQTVKGGTTSQDDSTFSASTHKPATSGSVNFASGILSSQTEAQRRTQFDAEKDDDDWRFEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZJ1</accession>
    <name>A0A8H5GZJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZJ1"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840508" evidence="1">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="181" mass="19608" checksum="15352ECDFB5F9B20" modified="2022-01-19" version="1">MDSLSNLSASFRLWPLTTLACASTLLPYAVAQSFVSDPLVDKIVPYTAIPCRVDNHTGGRGPQTGYNLCNSTTEGQDSLCQTAFVNHLDDFCIFAPPSPNSTIGDSEGEVVAWCTKPGRGTRLIPEGTLKGVQLVQSPGYIQIVGFIDPEKINCQVGDDGGRAGWAWKSHRWPRLLKCIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZJ2</accession>
    <name>A0A8H5GZJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZJ2"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="207"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="428"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="658"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="690"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="786" mass="85963" checksum="F2BB94F62D210384" modified="2022-01-19" version="1">MTTRDSNSCLQPATIPPPSTDPQRVHPGQTLSPDNALALEQSHPPSNSPLALESSSLVPATRSRSLSTDPSSEIDHPRARKRQRLDNPTQMRFPESDQPSTPPAAGPSSRGLDGLANSSTNGRTPLSNGHGFSSYNGLSNGTGGVPNGNSKHGKTSITRVNLPGSSLYEDSNVDREEFVRLVLQSLRDVGYTQAAATLEAESGYSMESQEVAQFKQYILDGSWSKAEDSLTRLGSRNEAKLWDAKFLIYRQKYLELLEAEKTTAALDVLRNEISPLDVESEELHTLSSLIMCTNPDDLRQRARWDGAVGTSRRQLLDDLHHYIPPSVMIPNRRFSTLIQQAHVHQLQRCIYHNIPANATPLSLYTDHQCDNSAFPRINTTILTGHADEVWHIVWSHKGDFLASASKDRTAIIWRVGSEGTDWEAHQILREHPYPVGTLTWSPDDSMMLTSADHIVKVWNTKTGQCLRTLTEHLETVTTLHWLSDGSGFVSGGLDRKIIYWSADGKTHESLVISPIRVIDFAIAPDFSRLVAVGLDSVDSKLFSPPTPSSTRGAGGRATPSEPLNPGSGNGGQLNAGRPNSDTRWFIVYDLTTRQQEIAKSMEGDLTSVKISPDSQYALVNHSPDEIHMWDLNLGRLARKYTGQKQGRHIIRSCFGGIDGNFVVSGSEDGKVYVWHRDTGAPLEILSGHGEGSVNSVAWNPKNERMFASCSDDRTIRIWEAPSTDDAVAATSLSQLHDHGSLYGHDLAGASSSSLDYKGKGKIRQLWDSATGSVAGDSGSGTPSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1F5</accession>
    <name>A0A8H5H1F5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1F5"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5374912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="444" mass="49299" checksum="21E92B9E74E10AE3" modified="2022-01-19" version="1">MSESIQYCRTHSQAEAVLIANYDGHVGFDLEWKPNYIAGRPQNPVALVQLATDRNVLLIQVARMKHFPRSLKNFLANRSIPKAGVGIQEDVKKLWTDYGVSVTSCIDLSLFARSVDCALFTERLGPYKDVPLVLPTPLDPSPPPVAAPEVSGESSTSSEPAPPKVPPSPHDFRLFRGRYRDPIGLARLVKAYHNKELPKEMKITRSNWEAELNARQISYAAADARAGYTLYEHLLGLFFALPEDKRPKRKYYAFDCIQGELFLPTDPESREPIYDPAPSQPTNTLPPLPDSLPREKWSLHNPEYDTGPMPPKKEKKDKDRAKGKDGRSAAEEGKPENENKEMKSENRRRKRRQPQREGHSQESSAPMKVVTTGHEATVNGANVTSTAITVASTSAPASTFTSYSTQNALGRPNVVGPDPTSAKRRKGGRAVEGVVERPHVYATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1K1</accession>
    <name>A0A8H5H1K1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2591106at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="3">
        <location>
            <begin position="816"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1291" mass="141600" checksum="C7376809D7E91BC8" modified="2022-01-19" version="1">MPDALSPVNLSHPHLRLRRPDDVPTPIAAWWTTSGGSTFIPSATGSTDDTTHQSKPTSSQSVDSTSVGGGGGVPTTFTTSVAVSTYTQDSTTVTSFTPTVITTTLRSSSSFSSSQSSSASAGATNSTPLSQLGFHDPVCVGQGLDSVSDGILASIILPAAIGLIIWLVFALIRPHFRQVYGLREWFVQQDLRPKPLGRGLFAFLFPHVPLVPDTPSDVSDAGHSPAEDAELFPSDEQLSQRALWISFLIVLGWSFLGLVGALPLYLVTTPCLADQNPQSVYGGSFSAIHDLSLLRLLRFIDSGAGNVSTSNLLSLHKRADGDDPQNIRPRIIVLTVLTIVLVLLPALWKILREFTRLVAYRKRWIETKCENKEMGWLSARDAPGFSGWGERRLKDFILKSGLSSSLDQNGGSNRNGNGRRHHPLRQETQYRDQELEPFKESEKANLEVDVQSLFSVSDTHLLALLIDERDEILENLEIAETKYINSFRLTTPEPSIADFEPPEPQDPNRPYISRPKPLGGNARRSRGSGRRSKNPAFAASSLAPTSFVAPSQYYRLDNVSGVNGGRFTNSTYEKSSLTENITSRVVGSRFQEVNRNSSVQYKELPLGSHLQVDRTGQLGPLEENSSLLYPDPRHYGPNYGIENPDSEGPYPPEDEWIDLSHEAPPDVASVDNGEPMTPPTRRSRRQDTSSPSRRETFPFRNKDAPTDPDDVPPPHLRLQPTQPFVRPMEGVNFDHLGLVYSDITQWRTKLKAINAEINDAQKGCYQDIADGVRIKGWILVGQGLHHIPGVQLIEGRAKEDIRWDVLQNERSSLDAFVMWTMVALVAIFLAAGLTAATGLYLATAPDVGHFLPFLQPLLRDNTLAAGIVTIFFPALAALLFVSLALFLVRWIAENRGSVSISGGQLLVYKATFLFLTLVTTALIVVVGALLFAMEAFSTGDTPSRSVANGSIYMAALLLAIIVQIAIVFPGILLLQPFRLWSVLRAEKHAITPRHRFRAVYPRTYDPSFSTCACILAVVFASTFSLIFPLISPACVILLFLTLVAHRFLIGYVYARTHSQTGGVLQLWLLRRFATLLSLQPILLGLIFLSRQFWIEGGVLVGVGVMVILFVEFYTTWKTRLPGRNSLSPITRNSLETFQNLAKRPGSSEGEGASLVSSPIGTRTRGSMASVLEMMSLTLAVMPSSSPTRGPVPLQTETLDDMTATERCSRTNPDAPPHLPSLPFGDHADEMAGILYAPELIAPPPIIWLPNDASGVARSEAVDLQKYHDLRVVLDVRGKEHGLHLASSREQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1V7</accession>
    <name>A0A8H5H1V7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1V7"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="127"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="511"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="643"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="685"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5375198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="785" mass="85641" checksum="BE69E5642DF1222B" modified="2022-01-19" version="1">MQAANPSHSPAASSPPPQESDPFQNVSAPERTVLEYLRARGYKAAEKALLDAIEATSEEEKTKATIAAEEMVKTLAVFSQSPSRPGENALNDSSNVVQELSAINSPASLQNLVASIGTVGAEEILSQDPTDKQEGFRELEAWVEGSLDMYRPEFRPILFPIFCHFYLDLIQRGYKDAALRFFSGFSPSLAAAHSKILHHLSTLLLPSHVQNDEHAQRFLNEKYMVRMSRSGFSLLVGWLTEGVGGEALGSGLGFSGEKGKRGRAAVMRVVNNHLRFDVTSSKSSAILSTTWEETTGLLSSLIPQPSGSSSVTKLYDPRAFNLSKGDLKLGPVPMNEELRSETERVLREQAMVERDPNVQYDLALTRPQPLPGQTAPSEADLLPRPPNFKTIDVDREVSAVRDARRRIRLEPSALTNVIDPNSPQANAVRARALPSICAYTLHDVVEGAPCLTFSQDTTLMAAGFAESYIRLWSLKGEKLRGMRSDFSSNQVRDPASLRRIKEKKGSTTRKLIGHSGPVYSVAFDPLSGSAAPPKHLLSASADGTTRLWSLDTMTNVVAFRGHENPVWDVKWSPMGIYFATASRDRTARLWSTDRTSCLRIYAGHLGDVDCVQFHPNSLYLATGSSDWTARLWDVQRGSCVRVFIGHQGGISSMAISPDGRYLASAGEDLTISLWDIGSGKRIKKMTGHSTSIYSLAFSQESSLLVSGGADWTVRCWDVKGAGGPKTRENGASDGGVVQKYGEGTSNESADLVATFPTKRTPIINVQFTPRNLCLVGGVYQASETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIX4</accession>
    <name>A0A8H5LIX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIX4"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22243" checksum="6FA6BDC512E92F2D" modified="2022-01-19" version="1">MKSDRVHKHASAASLSPDHHLIAVSENQSPRSRSSGAAGPDLENLHLCKSAKMSASARASQTGPTNTKDSKPVVSRKLAIKTQRKFPSFLFLPVVVFVPVGPETGGDVVFLSSDNVLFHVHQKHLEAYAEGFPLGQHTIPSQNEIIPLSEKSSTLEIVFQFMLPQSPPELDGLEFEQLMELANASEKYVVYFARRDCALYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPD5</accession>
    <name>A0A8H5LPD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPD5"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5364566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116132" checksum="B998895FC75D0F6B" modified="2022-01-19" version="1">MTIAASFATYASKLINRQPEASMSSSQPMFFSFTTDSSSRHAAQRHADDDDEEDLDDVGDFPHLSGGEDDVEDPYLRLDEDDSQPTRPLLHRSRSSSPLSGSSRSSSPHGGWLAHQATTGFGTRTRPRSPILQQQSPLPSTSNHPLPPPQTMANSSYEQPRSLSLANSLTDSLLPRDGYIRPVDVFSLPDPRTPTRFREKYQDSIWTSLWLFGLTTCFISSFLILFLARKPSNTPSRILPYYTLLHTVPLLTITTFVAAALSYANMWLMRLFARPVMIVTAICVPLMLAICALVGFVGSFMWEDDGYEQETWGETVGLRIFSFLPLFLSLYAMIRFYRLSQFDLPRTLARINASAALLNLTTDILVNNPLLLVLSPSLLLIALLGSIPFLTLIFRLSLVGYASNNEWHLRSWTPWAIFGTVGVWLWTWGVVRGILRVVVSGVVGGWYFGWKFPGDRDYEQGSSDEEGDGYERDEDELLTPPPELLQPQTQMWGNLQLPTSLLNPNAILTPAQTHTFHAAMYRATHASLGTIALAALILAAIRGLTLSIIFLDNLPIYLSEAWSWLTRFAFGGSGRVGGGLGLIIRELEGGVVGTVLRGLYSGLTVLGVLIRRGFYMALRWLVGWVDGWTRAVSGDVLVYAGMMGDGFWRSAARAGGLQAQVMAPADRGTGKGKGKSKGRRGQQRHHESAPDKILLHRVSHPSIPTLTLVPLTLTLPCALTTYLFVAHALGAPNYAFGAAVLAGGVTWLVGGFCKGVVGDIADTLWMCYCVDRDRGISPANFREMRQRSEYSAKEKRGKGWERVWEVFEYNPSRPVNSAPGLSGPARGRTGPSAPPHQQPVSQPQPPRPSRPEYQPQPGPQSTHSRQHSTTSQPPRLPLSALSSRHLSPPSRIFGASLPAEPEDIEIELSSSMRRMQQEANNRGELSSAKSANYPSAQGYAHSPAPAGSSARFEASMSSSRLDSPGAASLESGIGFGGMSGRFGVGSGSVGIRSPLAHDHEEEDGDIDPFKTEETDVSGYDVGPARMGASHSRGASGSGSRTGKQPAAGSDGDEGDGSQFFPGSGFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPR7</accession>
    <name>A0A8H5LPR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPR7"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5364958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="14330" checksum="8922A98A860A77A7" modified="2022-01-19" version="1">MPMQSTSALFRLSSLPAQIYATLKWMTIPATCVLTFIFFGFLVAGEEIENPFGYDKNDLNLDHFTRNIIRNELQALTSTAPPDPARWAFAPENDLLFARDFQRDERVTPDEWLKRGYHSMQGTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS32</accession>
    <name>A0A8H5LS32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS32"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="38458" checksum="C6165ED8DBED895E" modified="2022-01-19" version="1">MRLGTVALALLHPNQAGFVKGRYITDQTKLIRMVMTYTEATEKNGLIVSLDQEKAYNKVWHDYLWKVLEKYEFPSHFTKTVKYLYEPAKTTVMINGERSKNFHVHRGVRQGDPLSCLIFDLAIEPLAEMIRDSNLKGYDIPGTTEHLIVNLFADNTTTFLHAEDNFEELQRILDKWCLASGAKFNIAKTEIIPIGEKTYHVSVTQTRKTNEHAQPLPTNLHIAMEGEAVRILGAWYGNEIKAEQIWARNIEKVDSNLERWAKGSPSMEGRCHIIQMMIGGIIQYLTMVQGMPKSVEKRLAKCISTYLWEEKERNPVKKEVVFSNFDKGGRRVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUR8</accession>
    <name>A0A8H5LUR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUR8"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="250" mass="28477" checksum="9BC90C3E311DBA06" modified="2022-01-19" version="1">MVLGHPSCSQPDFTTSPSNDVLLVMPRHAVQEQWNEDAICKHCKEKGCRLLICKASNTIQNKPLTMVERYALAICLGKQKSHKKMLDQLELAIRAKVLVTKNIKTDLDITNGARREIVDIVLDPHEPKHNDDRPVTHLKYLPLYILVKMKRTRAQKLAGLDKNVIPIEPTSQKIYLKIQRGKKIVSRTLIRKQFSMTSAYAFTDYRSQGQTILYVLIDIGKPPTGKLNLFNLYVALSPYGYCKTSSQKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUT8</accession>
    <name>A0A8H5LUT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUT8"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14937" checksum="4E7CAFA35AD4C78F" modified="2022-01-19" version="1">MSSSQSTSNNASQASKPADYVYFDRSTTGFSDEALPKAKAAQLKMENYYKVVVEAAVARNTRRVELERKLQSDSLMPEERKQRQLLQLGKRESTYLRLKRTKLGLDDFRTVKVIGKGAFGEVRLVQKTDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV44</accession>
    <name>A0A8H5LV44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ssl1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_002024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV44"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ssl1-like" evidence="13">
        <location>
            <begin position="83"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5370702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="38692" checksum="ECBCD93B887DD62D" modified="2022-01-19" version="1">MNIDSESDAYVSEDDVDLSRNKGKGKAKTTDKRKKDKAKRKPKDVQAYTWEANYTRSWDTVQEDEAGSLQGAVEDWIARGRHLSTAMMDRDMRPTRFGLTLQYAREFILEWFDQNPLGQMGVVGMRAGVGERIGELSGNPQDVLKAISDRHKLEPNGEPSLQNAIEMARNTMNHLPTHSSREILIIFGSLTTCDPGNIHDTLDECMKNKIRISVVALAAEMKICRELCDKTGGQFGVALNEGHFKDLLFELVPPPAQRAISRVNGAGATNPAADLMMMGFPTRLPESSPPTLCVCHSELKSDGFLCPRCLSKVCDVPTDCDVCGLMIVSSPHLARSYHHLFPVKPFVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVC7</accession>
    <name>A0A8H5LVC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVC7"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5370671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="38219" checksum="1D332398867C5E19" modified="2022-01-19" version="1">MTTRSRTGLFLSYRDSSSRFRYDNDDDEHQRLIAPDLPPAWVDISDQVHSILADTQAKGPVASIPFVLPVLHLTFLPVQALERLHAKHVLPGFSDRSSEEHEIEAATSDITKDFRKCQALIQRIAPANPHQFPPSSSKSQSDAQAAKNVQRALAAKVQDLSATFRKKQRVYMEKLQGHAIKNQDLLVASGTISLKGSAGMSSLNEDVQAAAHTQSQSLMHASSTVDVDLQARDRELSEIAKSIAQLAELFKDLSVLVIDQGTLLDSVEYNIEQTASQMKDAVSELNTATRYQKNTGRRQFANFTPIIFITCRDGSDLYSLGSAGSWTDLEAWKAISEMDTEDWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW83</accession>
    <name>A0A8H5LW83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW83"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5371694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="68946" checksum="08D28B7A035532F8" modified="2022-01-19" version="1">MASHLANIFGTEQDRVNCSFYYKIGACRHGDRCSRKHIRPPFSQTILLPNVYHNPAHDPVCKLTEKELQEGFDAVYEDLYCELAKFGHLLELHVAVAMDGLLLTIDVPVPITVCDNVGDHLIGNVYARYEWETEAQAAVDNLNNRWYAGRPLYAELSPVTDFREACCRQNENGECNRGGFCNFMHLRLASKDLIDGLRVGQRLERRLNPAVGGQSGDGKGWVDRVQFDDCAVDVTDSVVKMIGDTFFPRHVGLRHSDFSAQELSAARSRGGLPPSSCTLDLHKRPLTAADLLSGIGITDVPFNITFLIQHHSLSASLLTLELTEILVSQIPGLFQILRHTSLLCKLLLNDHKLSAADLSFSPDNDDPEIELHVHLPVLPADTLPHLTHLRATPGLLRYFAPIILENSSNFSSLDLSRHYRAWRRHNYLSIARIDFESCFGTRTLEGLRELSICIDNTLEYNLGDYFPNLTRLQLTDFAGHDLESIRLQLQEMASHWPAQMPTGIRLFSINFLPRRTRGRPVLDTRLEIDLLSQLDGIKALTQARVMPNLEWFSYDKPVEWSRRPRVTLLSESISTDNASEGPDEDCDWYPSPVPDVGGELHKHFKAKIIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXB5</accession>
    <name>A0A8H5LXB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXB5"/>
    <dbReference type="OrthoDB" id="2734890at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034318556" evidence="1">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="21289" checksum="8DBAC015A59E40FA" modified="2022-01-19" version="1">MKFATALIALTLVVFTSAAPAPVPAGAPGNAQAFCQATHDARGNYAGGFNKGCVDLIDNCLDTLNTTRSTNIWDVKHCVSAAMCGGTSKLLVLANCQNPAIDVRGTSAPSLNFADVYAPIVGDCAWIPPSQGGSCPMTRQNFIDFVYGSFSDINIKTSHYPDVSLVINNWWASLIDWTATGQTVPYLNLNDWLHFPNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXL2</accession>
    <name>A0A8H5LXL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXL2"/>
    <dbReference type="OrthoDB" id="2966296at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034020101" evidence="2">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="97" mass="10623" checksum="CFB67554965973E6" modified="2022-01-19" version="1">MAKQIIFFIFTILLLGLFASASPLPVPRDAAAAKRGLRQFKLKRGDPEPFAKRADDDAPKPSSTPYIVNKRDDVSPPQPSKSASSSQLSSLPFHRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXL9</accession>
    <name>A0A8H5LXL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXL9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034731097" evidence="3">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="19482" checksum="99AF928030588E66" modified="2022-01-19" version="1">MSFTPTILLLSILRFSLLLGLVEAQTTVRRRRSSVGRIVAGVVVGCAAIILLLILCCVMARRRRRRRINPAILPTGAATGSGTTTGPSKFGFGLPFGHQNAPGTPHNNQYPGQDQQSYGGGAGYQQGGYGGHGYQQSNPNGFASSSSPPPAYGKEGAYQPPPGPPPPPAAHTAGGQNEQFVGGFQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYQ3</accession>
    <name>A0A8H5LYQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYQ3"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5374289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="109" mass="11469" checksum="574327802258A867" modified="2022-01-19" version="1">MKFPGHPLYERLVPILGAIMYGITTPVGIAVGLGVRTTYNPGSTTASIVSGVMDAFSAGILMYTGLVELLAHDFLFSKEMLNASNGKLAYAIGSMLLGCALMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ99</accession>
    <name>A0A8H5LZ99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ99"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="460" mass="50162" checksum="AE755E876AD412C4" modified="2022-01-19" version="1">MGKDKAHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYMVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAYTLGVRQLIVAINKMDTTKWSEDRYNEIVKETSTFIKKVGYNPKAVAFVPISGWHGDNMLEESSNMPWFKGWTKETKGGVVKGKTLLDAIDAIEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPSNVTTEVKSVEMHHEQLEQGNPGDNVGFNVKNVSVKDIRRGNVASDSKNDPAKEAASFNAQVIVLNHPGQIGAGYAPVLDCHTAHIACKFAELIEKIDRRTGKSLENSPKFVKSGDACIVKLVPSKPMCVESYNEYPPLGRFAVRDMRQTVAVGIIKSVEKTDKSGGKVTKSAEKAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B0B6</accession>
    <name>A0A8H5B0B6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_019037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000510">
        <property type="protein sequence ID" value="KAF5314214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B0B6"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5314214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="270" mass="29333" checksum="75D8607163769A82" modified="2022-01-19" version="1">MEAWLPRNWTGRFLSTGNGGLGGCIQYADMSYGSALGFATVGANNGHNGTSGAAFLKCTRVLADFVFRSIHTNVLVGKELTHRFFGAPHTKSYYLGCSTGGRQGLKSVQDFPEDFDGIVAGAAAADHNHLLARSPHFFLLTGSPNSPSFLTIDQWVNVVHPDVLRQCDEIDGVKDGIIEVPDLCEYDPSGLVCREEEGQQEQNTSCITAEQAKTAKEVYKPLFIFGKFAYPRFQFGAEGAISPLLFGGQVSTITAIRSRSSDTSIRFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7A1</accession>
    <name>A0A8H5B7A1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000462">
        <property type="protein sequence ID" value="KAF5317904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7A1"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5317904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="116" mass="12993" checksum="930633C8A39DD97A" modified="2022-01-19" version="1">MLSFESDRRTVNITINSFNIELSKEQRAKSFPEGNNQLAKADELDQVRAVCENVSEYRSFFLDSPSSGAVNGTEGDGDELSAVSQLEDRFFHKISRIRILVYEPKSGGMGPVFIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7R2</accession>
    <name>A0A8H5B7R2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000451">
        <property type="protein sequence ID" value="KAF5318320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7R2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5318320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="83" mass="9421" checksum="DF822CC475F1113C" modified="2022-01-19" version="1">MEVDKKFNQSPAPKESSQLLQLQMHFSDNINPPPPRSNILMPPPSTPPTIKAVQTTVGVTRRPTTNVIYDWRCIPELRRAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BBA5</accession>
    <name>A0A8H5BBA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000417">
        <property type="protein sequence ID" value="KAF5320195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BBA5"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5320195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="20473" checksum="137DEDBB8A04A0AD" modified="2022-01-19" version="1">MGIAIRRYLVKGPNRYYVLAFYGAVFGGVLPGMVGRWWFGSRQETKDSINATSTAVFFKGLEDGEDVEDVAGVLSGEGGGEESTTGGRALEGGEEEESIEHFRTVEVAAEAGKRGRAYRASAWRDGDFNLRMGSADCGIVMLMEGCYLYLDSGMEMMVLSNGHRLLYTLPQFDVPYGHARGEGVDLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BBG8</accession>
    <name>A0A8H5BBG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_018609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000416">
        <property type="protein sequence ID" value="KAF5320196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BBG8"/>
    <dbReference type="OrthoDB" id="3251057at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5320196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="756" mass="85820" checksum="053154AA400DF273" modified="2022-01-19" version="1">MSQHVGLKYATTTLEQRKNKGQGTGCKLDALPCSNLVTRSPRLDKAQDHIWSQQCFKKKKTKSRSDVDSQPEVSQASTSASAPAATVTKGLSSVRLAFNKRYEGKTMGEILPILTAKFQCPNASNVYNHFHAPTLEMHKGEYSLKFICKTKPSISLRRAPWEDSTGNLRKHINSCDPKEKGSIVELIATQHYDTAKLRFLLAIWVTCHKCPFKMIDDLELHEILTMLYHRVDIPHSTTISCDVKMIHEMAKVKVISELSAYTGRIHFALDGWSSPNHLSILGISLICYHDRKLQEMTLDFVQLRGSHTGKYLANMFLKEEEEEEDVNTAEDDELDPDREAFDEEVIEKVNDKMDELAAAHAIKITVGDFKEGKKGMAKVSALSCKNYYNCDFREDLKELAVTQGLKTQHTLSQPVTTRWNTTSEMINGAVEIEECIVDVTNRPAWNKPNGKKLRQLCPEEKEWKVLKDLQEPLDLFLSKTKEYSQSSVALLHNVILDMDSFREALSDVQDDAAKHPAVRYSMVKGIAVLDKYYSLTDDSELYRAVMIMHPKYKAQYFRDKGWEEDWIKTAIQTACQIWQDRYRPVTSPDTSQSKPKYIFLSTRSLLQNALHAKHFAQGANPIDDAFEKYIKTATQDDIDDPLVYWELQRKNNPHLAQMGLDYCSVPGSAMVSRFHHALSDSSLHSGVVVCSWHDLGFIPMDEVCEKFQQNNKRWKATAQSHERESAATETKGKTNEVVIIDDDDESGSNEGSDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BHC9</accession>
    <name>A0A8H5BHC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tuberin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000396">
        <property type="protein sequence ID" value="KAF5323199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tuberin-type" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1558"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5323199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1617" mass="178759" checksum="5140ECB0671ADE35" modified="2022-01-19" version="1">MNSDDTPRPRPRANTATTFPSFSWRRQQQQQQSQQEPQEPPHVASTVEELISALSPPAVPSINYARSLATLLTTHSPLPRHVLLDPILSSLCSPQAPHTLQAAGFDVVSAYWEKYWENETAPALKTSDKMTYFSLFLSENQEWITELWEPKFKALRALTKWGEEVTGIEVPCINLLKSWITSAFDRLQDVAERAERIERERSIEFVADFLSCLVEKAAVVSRISDEESAGILQFFADLIDRSVHSLSTPPNQSTIASPRPTHRRQHSSISISSLPSPMIPIPTSVSKQPADIAITLYLTHLNKLLKSLPPSFLDSILRVLFRAQASCASPLPRLSVVTHANAKDKQKSSYFEERVSDTINTLFSGPYSSTCMLILQRHLFPPTDTVNIQIAIQTSLGAHRSLRAYVRRALSTRLARAYINREASLGYSHSGAPSHLDLERDLMERAWPKEDIHSMGMGTKSSGWDAARFRRSLAHSVNEWVNICHKTAENATDSETREQFYRIRDGIERILEEDAGLLKDVFQELDSRDENVPLEEEEAAAVGETLYALAGYVLSLRNSDSTPYILPISQLNLALTSSSHHNASPFIRTLSSLLARDHNTMLIPLLSTTLLRISNHLIDDDTARLPSVMLDKGDLYPTSMEWIRNWSRVLGLSASATALDTPSESVSPSPGPGVITNSAHVTTGGLLLGYRPLTRRAVMGALEQVYESVKDMERYRRPLADLVYSFLETRRAESEGYDTMWKILADEVVQRLSENEFVLQMGMGLEEKGEDTVEEDTALGRDGDDPLDQATDGRVCRQGEADLSIDRFITFIAASAEDSDEGEQYSRYPRTQHHSEADDDSSETNMLSQTSSISATIPMQASNPPSPQMLYTTSPSPAISSLSKVQSVGDVSTPHAGQSPSLVAKDKEKEFPKEGKDVGLPSVMSILSSLTAGSSSRSTSMNPQQYPQSQEDAPEISATPLPGRREEDPSSTQLRVVCAASALVRLFTSLVFEPPGHPPAGAHKASPEQHVPIAKALTVFRHLTRLALQARSVRVRLVMLMFLMRLRVDRDHMLYFPTEERADPDGQVRSLAALIGRVADIDNELSEGSGAVVGVESPGDRGRDRRYTFVDSTSLDAVSELRKARARMPQDRDGRRPSRGRGSTAGSGQARSAASRSRSRAAGRMVSGSSTASLGTSGISSTPVFVPSSAFKTLLPPLPPPPTWQVPEKIPFTVTPLNISSEIFATYDPTNDYDDSFVRETVVLPISEYLSTILNILEKEKSWEVFSYVLCHLPVQLANKHLFCGPRSRGLISGILGALCTGITEGTLGREIPKEHWSSIGLKPRDAQGLAFNTLSVLISYKRCFELKQRHRLIEVFLAGLSEQPATIKCCLHALSLSAFELQSSTTRILTSVLEKLSQIMSNPTMAVHILTFLSIIGSHPPLYANFTEQDFKTVFGVALQYLQHHNRIVTDPQNSWALSQGVRILSYHLVYTWFLAVKLPDRPKHVKYITRQLLLANSGEVADGTVKDGKEGLGDVDDLTEVCFDWLARYTYASADPRPSNSVLQDLLMNPEHPRNSSSQSVVSSASLQTTSPDTTISEKAWLLGNSVVTIRALKKLGWIEVLSRRPSGYTKFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BT78</accession>
    <name>A0A8H5BT78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000356">
        <property type="protein sequence ID" value="KAF5328878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BT78"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="22638" checksum="E3C6F4256D6E6897" modified="2022-01-19" version="1">MSAQFGLLSRPGSALHSREPSVSAPSRPPSAQRLGDVPIQVRLGPSTRNSSTIQKFLANAPDNGNSPMASHSKACILLEQTFELENRVAEGSTSGQQFLSVFNNLAVLTARFITELPSIESIQESTESESGSPGNGSSRKRALLVIHTLARVALIKLYSLYEATNPSSSSERARAQQFQLEAAKEAARMIAMVDLRRAAFVDPIMADVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BV02</accession>
    <name>A0A8H5BV02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BV02"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5330079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="226" mass="23846" checksum="AF9B365CF125AAB5" modified="2022-01-19" version="1">MCTSPLVAELIAGAISMGIGGFLASQAEHDHYQYLQNQTAAWVIRSCAGEMEREVEEVLGPVGVGERTCKAVAKVLREAGGEEGGTPEQRQRDEKTGGGLRWSKDVGLTAFLLKFEQGLEEVPTSRLYISPFTIRLGYLIGGLIPLFTYFFIPQASTVLVYLCVVTGAVLLVFGAIKAQVTGAYTSNSTLGVWKGIAWGAVSTLLVGGLAAGAAFVIVKALEGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C1Q0</accession>
    <name>A0A8H5C1Q0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000308">
        <property type="protein sequence ID" value="KAF5332377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C1Q0"/>
    <dbReference type="OrthoDB" id="2686689at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="149"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="34192" checksum="7609B12A664958F3" modified="2022-01-19" version="1">MATPTGNYAAAQSSVSWLRFELTHTAPLADRLEGLLQACLQPGHPLSSDDFLDHFRLGPHDINPVVDICFELLRAHITQESFSKTFEWLSQIGTSMYNSFNHFHALVNPSRFAPEGFCDYFVLAEDWTSTPLFDILPVWTGCTKQRIYSLWHMDGNEKLRLWGFYVYRCVDGYSRVILYLYCTNNKRAKTVAAAFLDAVECYSWPSRMRGDWGTENNEVERLMIAHWGERHNAYLWGRLTHNVRIERMWRDVWKDTLEMFHKVFFYLEEISLLDMNSTRQDNVFLELASHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2Z7</accession>
    <name>A0A8H5C2Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIGR02453 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2Z7"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46240" checksum="1F2CA770CBEF5874" modified="2022-01-19" version="1">MSTRSSRASAAKSPSKASPRKSRPSNKRKAKDEEIEVDLGDGAGDADGVDDDADAYDEEEGEHVEEKKRKAYDSDALDEDSDFEDANADAGRKRKRKVVKPPKKAARTPRKKRKVKKDEEDQENEDEDVVDLKDGQEIVGEVVQAPKTGRVPPGQISKNTFNFLSQLAKPECNDREWFKLHEPVYRLAEKEWKDFVDSFTEVLMEVDNHIPPLPAKDIVHRIYRDIRFSNDKTPYKRSFSASFSRSGRKGIFAVFRPGGQSLLAAGLWCPGRNELATIRSNLLRSSARLRRVISHPDFVKFFGEPKPDPKGDRQNIFGGEDELKVAPKGVDKGHKDIDLLKCRSFAVVHHFIDSEVLEPDFKEKLAEVARVVRPFVHCLNDLLTLHDDDDDNDNGEDEDDGGEDGEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C399</accession>
    <name>A0A8H5C399_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000282">
        <property type="protein sequence ID" value="KAF5333871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C399"/>
    <dbReference type="OrthoDB" id="3062429at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="283" mass="30682" checksum="5E4A3D6D7D02B59C" modified="2022-01-19" version="1">MALPDGDYYIQDHFNDFVTANSSTGSLFLTPFAGNDNQQVMISFPIYRFYPHQEALTLVSPSRIQWTIIRGQGVAQLIRNAHYQLYIQSSQENTSLTNSPFPWYINETTDTDWYQLSRSSNQGGPYWVDNGKGVLTVTSGGWYSFFFLPIQLVDNNTTSMSALPTSLMNTTASSPKPTFSDSATNPDSATDGSGPGPNIGAIVGGVVGGVVLLALIGVLWFKITRRRVQAKSGASNHSAQSPSTLTAFTLQEPTMSVVSNKRSTLVPSTPVTTCSPPPYSDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5A8</accession>
    <name>A0A8H5C5A8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000245">
        <property type="protein sequence ID" value="KAF5335253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5A8"/>
    <dbReference type="OrthoDB" id="2744370at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5335253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13098" checksum="EEBAFFF4CF1BFABF" modified="2022-01-19" version="1">MNVFNHFVYCISGQTLVFADLQGSPVMINNHSGLKLFDVMTHTNTGTSGIGDFGLEGLHMCGEVCNNTMVDLEAFEIGAPSAPAPTSKGDDVDDFDDNVGQWLVQDQGEKERHTAGNGSSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C927</accession>
    <name>A0A8H5C927_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C927"/>
    <dbReference type="OrthoDB" id="10664977at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="741" mass="81484" checksum="C148573424CD7BE8" modified="2022-01-19" version="1">MVKRNITDNEVEANEGGRSEERQQEPPRKKVREVQPEDGYDSDSDEAGGATILENGTGVETRLTRYNGVGAPRATRDLQYYDEDLAEDKAIIVQVEDIVTRVEREEIARFSSELAKTLDSKILDSKTPITEATPLQFADVKLHEWRALLWGLGASDLKVIKNQTELNRLISLVSISHKYGVRAFEQDGLSAFYDKCLPEHSDDYNDQPSILSECSPYTLGRLYAIVMHVLDLSSSSISFNDPLINPLAAPKLNKRQIKSKTLGKSGHPVYCRNIPIMILRHWIARLMPEAKDFTKPLPEPVQPEPSDTVEYPFLEDSVPALVPDYIPDYNKNTGISEVHAAACYALLRTRELSSTGPLSTSTPDQEIDVDVDMDVPMNGTSGVPAVDVSEEVFMSKLVAPTHFLYRDDAKLRFEDKMRILEGEQSLQRVWERVREFGVDLMPLPGSGPPSSSKASPGRTNGAGVGTNGQAKGSPKVKGKKGGKPRSKGTKAPDGSMDPMDLDEDEDESMGNSKEPSSKEPYQFGSGAARAFTFKAKGGDHAKDEDDEIKGPLGSQSSPSYKFNVPESPPRKRTGRFHTPNPQSPSQSPSPSQSQSQTSNGTNTTRSPPRAPGASSIFKFNFIDPHAPHAPNSEAHQDCKRSWGHAFQVATGTASPSASSPSSSWNQTNIPPFDVLALLARVEKTLTEDKKLLNPVDKHGRSLLQPDCKKGALVIVKKVREGVWKTLGKHFAVPEPRRRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBF7</accession>
    <name>A0A8H5CBF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_014727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000199">
        <property type="protein sequence ID" value="KAF5338169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBF7"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5338169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="23832" checksum="0C3FE6B0401A138A" modified="2022-01-19" version="1">MVIGFVTLAAGHCTDHHQNYEYQPPRKGDARSPCPFLNTLANHGYLPRDGKGIDIPTVLDVCQKGFNIAPDVLGTFGKLGLLTLTNFTFFSLDQLNLLAVVTAPILVTVAAVLILVTVAAVLILVTVAAVLILVPVPVPIPAPAPIPVPVPARAPTLHVLPVEERGPDTALQLLFIHLDAVIAIPDPLDVHDLPGMSNIVLLLLGRHTLLSLQQQLRHQIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBQ4</accession>
    <name>A0A8H5CBQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBQ4"/>
    <dbReference type="OrthoDB" id="9514740at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="1">
        <location>
            <begin position="495"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="66864" checksum="9983207387664434" modified="2022-01-19" version="1">MPMFYLHYRSAKEVHGFFGKHRGVVITTMGGRALVSKLTQNAYPQVTQIFRESRGKIKWISFGPRGQYIIYTEKTTHSNCWFINKYDVYLRSVSFGAGGAWVVVEGNGHVRCHGLDPNIIYALKKKPVRAAQLSQSSPLFYFIEYADGEIQCNLPESWRHNIREIQEMAICHSEPSYRHEIWTPPQTVFAFGHKSDMFLVTYAWGGRHYRRNIESRAINKAVEEYGIASAFSPGFSLGENSSCFIKKGDSTWLSPLTRQTYPIVWDVWSSGVPINWVAFGPHGRYIADTKFRVYTSRSNDILGEYDRNPVSLRCASFGYGGSWVIVDHSGNVRSHGLVAGVLKKIAAGNVRNIQLSITEEKHCYVEYTDCSIDFTLPEDWHVHVANVIGVSLLGPFKPLAFSGFPLLHRIDQSEAEFFSVSSQFSMHWTYRCPKLYSIYKISPSSHSQEYRYQAYSKRIGNEQKLWHGTARLCNLGNDGLENAEPCSNYKCSLCQIIKDGYSTRRAQPTAMYGRGIYTSKTSTKASGYCSGSGLKAVLLNNVALGNIFGTDEACKSITPPIGYDSVQSVKKYDITCVYDDDAIQPVYLILYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCG0</accession>
    <name>A0A8H5CCG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000195">
        <property type="protein sequence ID" value="KAF5338551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCG0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="21841" checksum="0F3A87E2B2D45CA9" modified="2022-01-19" version="1">MSPGSTTSTATAASADTTTALPPTPSPIMSAYKRRRGGDVTGGPVIPILGQIRLSRLLRSKGGLTSWPLPMSKRTGGSVPSTPERKRVCTSSHSASPEYPFYPDTPSPVRETHGDQCYRHAITLIEGAELLHDLLFSDYKERMMETAWTIRGVDRQLSSMRDALNFVELVSRKLALKDEEDKDTEDEEDEDTKELTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD27</accession>
    <name>A0A8H5CD27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000184">
        <property type="protein sequence ID" value="KAF5339501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD27"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034308601" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5339501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="14345" checksum="768BFF7EE64AEB1B" modified="2022-01-19" version="1">MFSFIRISVLVAALTLATASNAQSQAQCARNYTVHLGDFCDGISAAQHTSTFQLANANQGVINADCSNLAVGMPLCLGDLGKDCSTVTVVESGVGCATIADNAGIPLDTLLHNNPNVNADCTNIYPGEVLCTSGGLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGZ1</accession>
    <name>A0A8H5CGZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000168">
        <property type="protein sequence ID" value="KAF5341298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGZ1"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39731" checksum="AA37E46C6DB88F02" modified="2022-01-19" version="1">MEISELRQGIDLPTEGHNQGLDISQLLLTFNTEPMSAPGEVRHELLGASDRTRSLLIAAWLSLMIYVLVIDRAIYYFRNYSTDKLIIKAAVLGVVVCDTLMTVVACTNCYTFGVIRYGSGFSNIDLNFRIIDDAHICRRRASSAIARLARNIVLRLHRCFGSNRASVYVGQILVSVTQSSLVYTQLAGTVYSIVALVIGRRATNRPQVGILPGVITWLASGMVADVSIAALLVKYYLSTDVGIGSGRRLIRRLVALAVKTGSFTALTAILTLISFLSAPQTNVSLIFKYTLPRVYSLTLLYNLNIRQKLRSAERTRSSYARRTVPIDILVNRREYPTPQVRVTSPLVSNDDRVQRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKG8</accession>
    <name>A0A8H5CKG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKG8"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="521"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="902" mass="102622" checksum="3A891B8212DA02F5" modified="2022-01-19" version="1">MRLFIVSKFSPLPIYIPPSLPAIPYIQRDDSCFEPLPPSHPLHPLHFLFLLSQHSHTFNNSPPDIMRAASFAGVVPRTPPRSSPHAQTQVMSTPLARGSSSQVDLADNHKVADINTYLEEDIKDRVYLDLEVFLKLVLDFGDAERKKKETKINNVMKNENFERVWNYYRGLCGLGSTTEKGLYEPLLKVIETAMKRLFPNQQPFTHFNEGDKFILGSYARRKPDLPALRPIFGLDCQTAEDKLTKVHWPMVEPFGELKLTPKQGGKRTGFALDWADATPGETPQAVTAPATQNRYNLRPRSASGGSLPNAFPTQSHTRSLHPIPETSTHAESKNEEVEAGKKNKKKGNKGTKQKKKTLGDEMEPEEENLLTKPSDRRLHTLLQCAGYGLESLSSGLLRTHTVGFVMDGTFFQLCYYDRSKVVLSKPVDLSEPNSMFLFLATLYQLGSLSDEKQGIFPSKGDGKSLPTLEPSVNERYTRREGGNYTSGPITGDSLVFPGGNAFSGCKITVGKEVFHLGELVHRAHAIIGRGTTVVRVKWNDKDAIMKLSFCGAERTPEEELVKSARAKATEEGHDWALNHLPNILYSAEYNLAGLAEDRLATYFEQQRISYERRVLRITVQEVLTPITDAVLEPKDYAQIFFDVLQIHRWLVDHAKILHRDISMANIMFREKDGKIYGILNDFDLSSRLPPESKASSRQRTGTKPYMSHDLLNPSWVHGHRYRHDLESLFYVILIFCSDYGAKGEEDKLVKVTEPHFQKWFTGSFEDVRTGKISWLLEDKPLIQVTEFFREFGVFYLTKLRDLVIEGHQAKNVYRSAWHKYKNSEKGHKEYGYPFTQVFTETFEWETLNDTVTYEKFRDVMKSFPVRTSSGKWEPFQLTMHYENPLPLNSSDFGPPPDNDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN32</accession>
    <name>A0A8H5CN32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN32"/>
    <dbReference type="OrthoDB" id="3231781at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="250" mass="27311" checksum="536132DACDBC2AC9" modified="2022-01-19" version="1">MSSVLSDPASVLAPTLGALEFGVLLSTLLYGAAFVQTVNYFQGPFTSDHASIKLMVIFVWIIETIHTGLLWASLYNKTIENFADLEALAQVHWTIGLSVPITNLIVCSVQGFFAHRVSVLSKNPYYFTFAIPVLLLRLGLGITCAITTHSATFAVYIVKFRWLVVTTLAVGAVIDIINTTALLLCLRQGGAGQNESEVRFNSGETESSRTRADHRVLEPHTLEIQVDITNSAALSEAVELQSIDLKQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNP2</accession>
    <name>A0A8H5CNP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNP2"/>
    <dbReference type="OrthoDB" id="3049421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1177" mass="110940" checksum="F8A9E70E9B1F16BE" modified="2022-01-19" version="1">MSNHQRNVRMGTPLNGSTDTLSSDMSSRNIVARRGSDSAGPTAPANNSNSESSNSSSSSGNQSSSSDSSASGSDKSASSDSPSSSFPSNATGKDASSSSGTSGASPSSPDQGNANNTGGSGDSKSSASDSGNSQKPSIGDTSGVSSSSGKGGDNGVSIGLNVPGVVDASVGVGSDGIGLGVGIGKGNTAGSQPNSGSQSGKNSSSAQDPGDGQQPAPSDGQSGQSDTGKGQDSPSNTASSSSGNSQSNPSPGQSDSKPDGNGNQGSSSGGSGVDVNLPGIGGVDVGIGGESSSGSKSDDGKDADAGNDESSQNPPSSTSDNSSSSQSTPTSSQGDQKPDGDGDQGSSDNSGIDVNLPGVGSIGVGIGGDKPDDGKGADTSNSGPSPGNGGGLGVSIGLGDIGVGATVGAPDPPTASQGSQGGSTGGGKGGLGVSVGIGDVGAGVTVAPPPPVQTSPPGDSSSNQGGNNGGGKGGLGISVGIGDTGAGITIAPPPPVQTSPPDNSQQGNGNGNGAAGGNDQGGIGVSVGIGGAGAGVTIAPPPPVQTSLPDNSQGNGNGNGAAGGKGQGGVGISVGIGGAGAGVTIAPPPPPPSSTSPPDNSQGNGNGGAGGNGQGGIGISVGIGGAGAGVTIAPPPPVQTSPPDNSQGNGNGNGGTGGNGQGGVGISVGIGGSGAGVTVAPPPPPPSSTSPPDNSQGNGNGGASGNSQGGVGVSVGVGGSGAGVTIAPPPPSSTSRPGNPQGNNGAGSGNQGGNASSGSGGIDTSVGGAATVASNPPPIVSSPPAPPSNGNAGNGAGASDGSSSAGNVEAGNGNGSSGTAVVISQPTATVSANNNSGQGSAVGGNDNGALGSDSPSSDTDFTTATSISSIPVVLGAVGNGSPPPTAVITITSSAPVISAVPTTIFSVDTNGHTSTIITDTPSTLSFSSFTSTISPPFSPAPTSTAASPSGRSASTGPMIGGIVGGIVLLLLAVIGLFVYRRRRQGRHLSFENATPHSGNSRDLEAPPSPLFNPMAMVASSPRMTNSNVARVVQPSTDLPFFDLNDNTTIIKRRATFKEIPSNETRLIDVEPTSDSGHSFETARTDFSVIPPISTDPFADPFAKAPLTPTSMSPVSPRNPFATMPPLPSQNNTNVPVKSNNPFADPVDDLINALDAPVSNTRLSRASSSGNAEFGFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNZ6</accession>
    <name>A0A8H5CNZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNZ6"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="461"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5345274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="547" mass="58843" checksum="1BB8C6ACA76988B0" modified="2022-01-19" version="1">MSLKAELETWAAALKAYDEEDFEKSLDLFSRIADSSKILTNMGLIYATLGEHEAAVEKFIEATGLDNYLAVAYFQCGVSNFLLARYDLSYKDFDEALLYLRGNQAINYEQLGLKFRLFSAEVLFNKGLSQIYMGRTEEGLADMQEAKREKATDEHSVIDDAIADRGEGYTVFSIPVGVLYRPSEKKLKNAGAKSYMGKPVLIAAADSRDAFTGFTGVTNMKNGVTPTGVYMEQAPSLESGLGRSATAPAALPKPVGDSEPRAANLTRANTTLNVPTNARERISGGDSAPPPALARANTTTAPRGQPMGGPVRGLSVRKPGSPAGGGGGGGGAPPPPLKEPDNRLTEFYDDYLDSYGGSESAPPPLPTNTANAGPPDRVAAWARTNANPSNLPPSAMMRSGSRSAPTSNYAPSSFGGGSLRRKVTRRGTSRAASSRIQSTYEEEEEGYVSGDYEDGPFELIKIRVKLHYKDDVRGMALTPETPFEEFMEKVTSKFGKGFGGLSLKFKDEDGGKVTLQDESDYDLAIETARESSKGKPEGKLEIWCADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPU6</accession>
    <name>A0A8H5CPU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPU6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="66" mass="7465" checksum="6E097E2D30AE1D7E" modified="2022-01-19" version="1">MPYLESKGKGPNVNEKSAMTPMSIFSLLYLHNSSLAHFLMKQEQEMLRNAPILSVLLNGTIWDART</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQS3</accession>
    <name>A0A8H5CQS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQS3"/>
    <dbReference type="OrthoDB" id="2501483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040898">
        <property type="entry name" value="CxC6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18721">
        <property type="entry name" value="CxC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034075112" description="CxC5 like cysteine cluster associated with KDZ domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="2">
        <location>
            <begin position="159"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CxC6 like cysteine cluster associated with KDZ" evidence="3">
        <location>
            <begin position="400"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="79067" checksum="C78F74875442AE0D" modified="2022-01-19" version="1">MQPVPKNIAGLLLVESLYLCSLGNVCVQTNVTESALCKHPTCHFFCSTLMAQCLGQALSALQDATTCLSFDFSLILSFVRLCCLAKPTLQLDRRTVSSPPDSLSSRVVKIISACLDASEDVVNELWNALKVVVWQHGPIAASEEEIRLFNVHALQWDTSYRHLYPPVHTCQVSTCRHHILNSEREFNLCEPSTYKATLFTLKDGVLPIYTTSLYCRGCYSRYYPNYRVHKGSSTRTYYGSVPEVLQVSRDFFIESAVLELFCNQKVFGWLSAGNCSRIYDWSLATSRQYIKNNPLAFPGAALLPFSQVPDTWPVSARLRPEDVLNGFFLYSLLLHKAERSAVLILPHDEKSHRMRLRDELALRNKLMEGVGQEQYLHACDLCFKVYEDENGVQRKLQAAVCDGITIGHPCCAVHDCQVPLASHADRFCSVHMMSIGKKCAVVDCNVDHDKGFQTCNEHRPLEESYYIRGQAFFQLKARLKKAGVAVPDNSVSLEAQVTHEEEECEGKSEMGNRKLKALFGQCHTHNEQLAMRTCGVVMSRATFFGSEAVSGVNGFLKATFPTPQSTPEFLIFDNNCQLMKHQAAIGDTHFKDTAQPVDVFHFRSKHKQSDDFCQAFCNPAAFPEMRTSDGKWTFNTSICEQTIVWLGGYIAVLRNMEVTRYNFYLDEMIKRRNRYVIHELERKEHKPWTVPAELVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS04</accession>
    <name>A0A8H5CS04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS04"/>
    <dbReference type="OrthoDB" id="2576496at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="221" mass="25059" checksum="34B3C08D88B48A4E" modified="2022-01-19" version="1">MTYRRASFLVDHLESDHSHWQKQTLGVISSELAPSWRPSPFPDYPRPDPPPDNIPTSSLHLKLSIPNIPLPRPPRPTLPPIATPIQSPLKARLYRTPSVGMLPSQSQSQLQSPLKMAFMKRIKQTDSMDTVLSMAQSASDPQNDRIPDLDDLPHLPNDDAWKENWIVWKRPAAEDKDISSSLPYDAHMPVSDDFETPVSILYDVFSRRVDQLRQSGHLNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTD2</accession>
    <name>A0A8H5CTD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTD2"/>
    <dbReference type="OrthoDB" id="2575973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034932825" description="DUF6987 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="20488" checksum="3B61355A1115848E" modified="2022-01-19" version="1">MIFFKAICLLSIFSIAASKPISTSQARSNDVTLVENHRAELNITVGSVLNTLQDQVNTILPQIQNLDNANAKTLSPLIDDLTEALDNAADDLSRIHASGKVDDKAKRQSNDNTANLIATIVRDITLTLDNVVVTANELPVVGPLFNGVDKSLNRVLFGVGSLAQGVLKLVANLVLNVAGIPGSLGLGLTLGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUW8</accession>
    <name>A0A8H5CUW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUW8"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112300" checksum="A1D6DA39CE121095" modified="2022-01-19" version="1">MDALDISKSNWPNTWRNTPLTPPMSTAFERRKMAEPQTTATTTTTLPSIAFLDRQLSDRNVMSALPPLTPPDDVPPPHYSPPSEMDVDPKHQLFVDTHLTAVDWIDFSRTRSAHFIAEKTCEMICYLWFRPPDSSSSSSSYSPPNLSSSSSPLFNRPTPSSTLQLVATPQFVSFMQKLLETTQVSQSVIVLSLHYICRLKDRNAFTPAQAGSEFRIAVAGLMMANKFLDDNTYTNKTWSEVSGIGLEEINRMEREFLMGVDCNLYVDKATYQSWLHLLKGLVMAKERDSRHFRKTRLAARGARHPPHPTAHLTTTPSRYSTRGRVPAQYRARSTSPEPTRRLPYPQVPPSYSFTSTFSYPTAHTQQPQTQPPQYSSTPDRLPEHPAYASASYNSLPPSPTPTRPAPGAGSKRSAATAFSPTSAAFAHIPTKRPVSISLQIPETSAHAISNLLSSNGGSSGSSGPSSNSPLEGLNAFAGMSIDERPGQQPHHQPQPSHQSQHTTPSTTMSLTSSKKPLVPETLVAGYALDPERRTSVPKNLYFYTLACSPLEFADASSSSTRSVPTNDDAVSEAASQDDDARAQELLDADTARYDRIRRGARKARLRYHQPGDRSATPASSTTDNSVHHANPFHYPSSTFGSSTSLHSIWNGATTGYVYPTLRNAMGAGFGYVQSASTSPNDVHVSVVPPTAAAYHQMQQYYVPSSVVVPTQAPAVTVVQAERDEDMGESEGEFEEDEEDEEQDEQDEEDADNGDDEMGSQTEGDDEDEVDVEEVEKPRLPHFQDIAAWVKPEYRQRYAEPAQIQVPSHAQLQTEPPRYPGHQQHYRQSPSQPQTAHTPSRSTHISTSPQVQQSRQRTPVHLTHQLHTPHQSTPTHVSSRQVQNPQTPVVSSSASTSPYVPTHSRSHGHSHSSRYRHEHHQVTPEGSPVKSAPFANAGPPGVHGYSLGGYSPSYDSVYVAAPAYGLGRGLAAYAGTQSPTYGYNTTASSANHAHAATTYPTPVQSYYDQGHGGELWMKRPSIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVM1</accession>
    <name>A0A8H5CVM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TERF2-interacting telomeric protein 1 Myb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVM1"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="887" mass="97030" checksum="7F0D176227429519" modified="2022-01-19" version="1">MGSRVAFTEEDDRRLAEFIAFFSAANNRRGNVIYKMLTDNKDNLWPWSSRHTWHSWRDRYVKRQDAFDRMIRKIQTGATIVGQATPGASNAQAGPGPSTLAARRADTMGATNATRKRRRSSSPGDSGAQAVSPKKKTARGRPTTKRVPARRQEFVDEDSDEEVQPKMHSNAATSHQPIQNSDAESEENVSERVEVQNLLSLDNEHANRPRVVPDHREYVNLEALPPREDPRLSTPLIIVAANSEEAASSKLGSGLDSDVEEDMVEETVPATSKSGAIPFSRPSPAFMTTGKSKTITAQSNNDANRANIDTSLRTHPKSENHPPNSKLAISFSTSASGVAVGADSEKTSQAQVGRPIKENGKERALPALSLYGEGSHGVVASMERGDFSTENNPAVPLRSSAKLFPHKETVVEASPAKHRGSGTYPIRAGHPQERAVATSYPVLSASKPSPLANEIVEDSETETESEPEAETKLAPPAACSRSSTPVSDGGEGVRAGSRPSGSMESISLNQGSYEEESGYDLVVEDLHDIDATQRIGIDGVAWDDYRVHDLRDLEQTQNIHDYVLGDDEGIGTQDVEMGSPPIQDCHEEDKENRQASSLPHLLQHEASRSLSRSSTRSSLSSSQSQEPHQHHPFSQTQTQVPAWMLESQSSQSTHPFDHSSEESQTQATRGDNSLGSQESPATLDEGLRTMSRALKFYLPDPSSSNSEDRSHHGQGASSCASSGHEREDGLSLHKHHRDDDKAKGVLSMLSGQGRTLARRRTELHDEATEDEETNDEGEDFRCGSPSSLFSVCPSPTPGSDDTVELEEAEDTDASDTEAYVDRTLIRVAERYGFPKMYVRELWKSVRDCVQEDAVGDGLAEVQRIIETLDGVKAAMLDEWRFRKKSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYE1</accession>
    <name>A0A8H5CYE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYE1"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="23933" checksum="BB95DA5342F14A60" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFARRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDSKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKILKPAVIDPRTHHKEYQDDDVEFLFDLSTETQKKPQSLPKMTTTGTRSQNGGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYU4</accession>
    <name>A0A8H5CYU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYU4"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034486893" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="395" mass="41860" checksum="CA7C1888A1FB065E" modified="2022-01-19" version="1">MLSQTTIVSVLAGLAVAPSVLGASQYNLVQDYSGADFFQGFKYNESVIDYNNYGNVHFLGQSQALSSNLTYVNSNGRTVIKVDNTTNGQGDITFGRNSVYLMSEKTMTMGSLLVFDANHMPFGCSVWPALFTQGQKWPEQGEIDIIENVNQATKNQYSLHSGANSGSCVQPPSIFSSQTGLSQVSTPNTPNNCTVLPTTDQNTGCVVQDSSDGSFGAGFNSNGGGVYATLWNDDGIKMWFWERGSAEMPSGIGGKGALDPESWSMEPAAYFPASGCDPSKIFGPQIITLYIDICGAFAGNDQVFQSTCGSIAPNCSAMVPDPRNYDNAYWEINYLRVFSTSSSSSSSNSSTHSNSNTQSGSNSASASGTLFSSRAGNMLGLVSGLAMFFGVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0Q6</accession>
    <name>A0A8H5D0Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0Q6"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5351529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="600" mass="64948" checksum="C066A52DBFD663DD" modified="2022-01-19" version="1">MAQPIALLSVYDKTNLLDLAKSLQSLGVRLLGSGGTAKKIREAGIPIDDVSDITKAPEMLGGRVKTLHPAVHGGILSRNIPSDQQDLRVQGIAPISIVVCNLYPFTSTISKPECTVADAVEEIDIGGVTLLRAAAKNHERVSVLSDPGDYTSFVDAYKGGNGDVGQALRSNLALKAFEMTAKYDEAISGYFREQYASGDLPKEKLAGPVQRIPLRYGANPHQKPAQAFVTEGQLPFKALCGSPGYINLLDALNSYALVKELQEALNLPAAASFKHVSPAGAAVGLELDETEKKVYGVDDLKEPLTPLACAYARARGADRMSSFGDFIALSQPCDLATAKIISREVSDGIIAPGYSPEALDVLAKKKGGKYCVLEIDPTYEPPEIETKQVYGISLQQRRNNSKIDAKLFENIVTKQKELPSPAQTDLIVATLALKYTQSNSVAYARNGAIIGLGAGQQSRIHCTRLAGGKADIWWLRHHPRVLSLPFKKGVKRAEKANAIDLFVGGEPLEGGEKEQWESLFEEKVEPFSDTERKEWANKLDGVACSSDAFFPFPDNVHRARKSGVKYLAAPSGSVMDEECIKAADEHGIVFAHTSLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2G8</accession>
    <name>A0A8H5D2G8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2G8"/>
    <dbReference type="OrthoDB" id="3231188at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="481" mass="53206" checksum="55351D36A3BD05E5" modified="2022-01-19" version="1">MSDNDELGEFDNSHEDDNDLPTLVLPPVGASPALVYQRLQEAHLQNQTLRQRNSELRLLRGQGRKHEAPVNPTLDPWMSRITTLANRWMVMNEPWINVDIFGHPVPTDLPDPFSPARFIDKNTYTAGTIAELHRHLQEPRLQELAATFPAFKSEFRKAVNNHRTHTTDRVRQHAAIILCELSPPACIGVARSGEECADSELLKTLWTQGKKDISDEKLAPIFFPEQIINPHTTFLNEYQPRIIRINLFAPSAIKNPDAPITGKHLVGFQWGVRSVNASCIAWSAIMSFKLCFIVSPDKEFTEVGTISRIPYREHFQAYRKMIVLAESKGTPWAKSLYDFYNRRVFAGVSGMEFAASPSSSAAVDELDELMQHLMAPNPLDAAFGNTSDNLPPIISSSNAVPIIPARDSNTQTSSPSDAAQADDNDDLESVGTGSLNAPRGRGRGRGRGGSAQGKGKAKDVSSSAPEAEPERPARATRSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6U3</accession>
    <name>A0A8H5D6U3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6U3"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39201" checksum="A9EB9E4409678C84" modified="2022-01-19" version="1">MPTSNPLTQSESDLLHDDGVFMMNSVPALMAETLMWAVSFAAYTLRRKQYFHHKPRVILTATILSMFLLSSALFSLHVWEFMYQVKRIYLDSSIEGQSFGDKSSTTIPAINKGGFVYNILFALEFLIGDSIVLWRTWTIWYSSRRIVWLPIFLWISSLGCLLAWILTRVIQTIAKVGWRRFSILDDDPDFLLLTSYVLSLSVNATSTLLIGFKAWQYRNHLKLSYGKSSLTERISRILALLVESGVIYLTFSCMQLINFNGIRTPQQSVSGSASNIAGMVIAGIENQLLGLYPTLIIIIVNLRKTILDSPEESSSSLAEMSTVSGIVFNHIQTLSQSRDGRDGSRSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EV81</accession>
    <name>A0A8H5EV81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000526">
        <property type="protein sequence ID" value="KAF5313541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EV81"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5313541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="194" mass="21729" checksum="AAEBC037F4C1D95A" modified="2022-01-19" version="1">MASESSCNVINDCRKLYDIIWGCLVTIFTCTWVSSNHTSTAFRAYLGSPQAVFPDGPGGHSSRVDVIFCNASVLGHKEIFQRAWILHFDGGFVTRQGHHPIVEPEQFMEEILADIRATKVQDIEDKSKANAVSKGLALLRTLWFPVQMLARAVQHLPITALEIATVGFTILNLLMYGLWWYKPLDVQRPIMVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EWE4</accession>
    <name>A0A8H5EWE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000495">
        <property type="protein sequence ID" value="KAF5314816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EWE4"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5314816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="14922" checksum="FEA72B1F585E29BA" modified="2022-01-19" version="1">MAAYIRSWLPSLSSSSSPNESTSSETSPTVTIQQDVEDDEGSDTEKEDNDIPPAFPAISSAQRLSSSSKSSSSATSSSNGIPKILSDSQLMPPPPLPASRVPGVGSSSLSVPSSSTSSLAVPPTTTKPPTQLGVPKTKKRKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EZK3</accession>
    <name>A0A8H5EZK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000458">
        <property type="protein sequence ID" value="KAF5318209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EZK3"/>
    <dbReference type="OrthoDB" id="3225366at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5318209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="339" mass="37389" checksum="51F20B370E52011E" modified="2022-01-19" version="1">MIGQLPDKAFILSLTLLPGPYSRRTGLLGQLLPLFSSDWSDLANLSLKNTKKLAASGNVGHLGAYRIAHTLKITERLPVLSVPLGAYPKSSIDKKMDSSPSDTRLSADTTRSDTCRRCLSPGTDTDSTISVDSLIVISRRTSRIYISLKEGWHTSLQAAAVVSTLFAQTAAQFLGTVKTTPIPDTASQTALLIFSYGGIIFGYSATISSLFLNARIASLPVLAKFTKGSDRDKMPQLETQPIRTVMTWCHVGWKFEYLFWHFFVFVCVIEWPTSIAIPVAMGIVVMWSVLEYWISSTFIMCMYYESEFEAGSLNTWGDSEKATPTLTVPSQQLELANDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9M8</accession>
    <name>A0A8H5F9M8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000354">
        <property type="protein sequence ID" value="KAF5328915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9M8"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="161" mass="18100" checksum="C380EED388C04134" modified="2022-01-19" version="1">MAKPEPFKGKASDVRPFLAVFKNWAMEQKDINTDPKMIRSALSFMQGEAATWAAPHIEEAMKALTSPANEALFGGVWATFKETFKAHFGSLDEQADAQKKLEGFVQGKQTVVKYVQKFKSWGMWCTVPFHSIHKGIMTMTCPCEFFDHENCGVSCDSSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDK2</accession>
    <name>A0A8H5FDK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000302">
        <property type="protein sequence ID" value="KAF5332879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDK2"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="474" mass="53948" checksum="6A1AAF6D527F497E" modified="2022-01-19" version="1">MSSPKFIPPINAQGPNIKAPPRNLIFMFDGTGDEIDDDVTNVIQFSRLLYNHPKELDPTKGIGMWKAGSNRSKIPFYGPVSRTVDKAIAWNFEDHVMDAYKTLTEQYKEGDKICLFGFSRGSYTARTVAAVVGLFGLLPPESRNDDSIFETIKTIYFGPTRKSFSPDSINEFHVKLKEFLEQHRTAMVMIEFVGVWDTVNSVGLITTTGAMYTSSAPNLKTFRHAIALDERRARFDRSMWYKKENDGKKLKTDVEQVWFAGAHCDVGGGSVSNDTKPNLANIPLRWMIRECFKKETGIIFAANELQSHLGMDPLCLYPIVKPRPAPLPLRDDSIVQTVESVNKSNSEKKCPVTATSTEEEHDLWDSLAPIYDMLVIKWYTWDLFERFRMKKWDPVRGNTHEANWWAGRRIYVNVPPSKEAKKYIFDKKVRVHRSVRTRMMAKSMDPKGPYVPAASLQVGGQNISVDSDLVEWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGF9</accession>
    <name>A0A8H5FGF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000235">
        <property type="protein sequence ID" value="KAF5335876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGF9"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5335876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="663" mass="73875" checksum="EF7643BE0D757473" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGEHTRTDVRDTAPTSPSSPPSTSTSSIALSVPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYTEESDAIELIEKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANTAAPFQKPSDVKKDRKCFNCNKMGHTTLTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWVQSISSSDVEMEDSETPVSHYISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLQLAGDMRVEVRKDNARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTTETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNAYYADNVGDPISFKDVLNHPQRDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLL9</accession>
    <name>A0A8H5FLL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000168">
        <property type="protein sequence ID" value="KAF5341291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLL9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="77132" checksum="B2A9FC6388BC3F14" modified="2022-01-19" version="1">MRLLSTKDFKVKEFFTDIPLYAILSHTWEQEEVTYQDIQNLDVAKSKAGFLKVLGACARAHHYHFDWIWIDSCCINKESSAELSEALNSMYQYYEDAAVCYVYLSDVSRDYHPRSNFKDSRWFRRGWTLQELLAPEFVVFLDRNWERIGTRWSLRDLVSVATGIPVDVLKGQIISKYSIAQRMSWAAFRETTRPEDQAYCLMGIFGVSMSPIYGEGGAKAFMRLQQEIIRISDDRSIFAWVAAPSMDLASSEEDKPRGLLARSPYEFRMSGNVRPSITEVMGNKSSYSFNNNGLHIHLPLNPTSSSSVHSGEDMFLAHLLCQSTRDGSYLTIYLRKTSGHQYVRCYADEILLTSSPPAMERVRELMVREHLVTGRRFRISNTSGATKYNIELLRSAWDFLYHSSQPDSCIVSCIDEHTVSVIRKMDWGVIQYKSQKTGDLFGIDLTFSKPALKMNGGTFIRDASVRRDTLQGKLNGGGYIFIASERTGDPQEKIEIGYLAKDDPEICLWTSPLRVPDLGIIVSSRLSTKIVDYHLKFEGVFPPDPFCRITQDMVYATAFRPHPDDLQESHHTFRVLTFRWDDWDGQWPTYIIHVAFGLQGSSVWTDVVVQNPSFHRETSERVWKSYLESGTRAQKRTKGMEVKSKVDSETLTAVIQKANNLQLGDYLLRMHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP12</accession>
    <name>A0A8H5FP12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP12"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="538" mass="60983" checksum="BD86509E488537FD" modified="2022-01-19" version="1">MTVPTRVPITSGHSQNINILASLRSNFGTYTANLKDVVQCLREAEKTASLRESQIVSLQNEQQRLFLRISRYKSLLAPIRRLPPELLARIFGFCCKESKANEKMDCPVVRLSQVCAGWRELARTTSSLWTHISVDLSDCEYSIQRVLSMVDTHLSLSKQSPLHISLVLPVTSDDARAVLRAFVPESMRWETVTLDVDRCHLLDTEFTAIKDRLPLLRQLELWPTSTGTFDTESAATVDSFSSAPNLRSLQLGVLDDGGEIYLASTEIRVPWTQLHDLTLWVHRPMAIRERLMSASEARTVTIERCYGPAEDAAEAEPVVHFMRSLTISVDKWDRNLTVFLRLLVLPQLTSLCLSGVEPMYPDTELHLSDIQTFLIRSGCNLTSLSLVSLSNTDHIILQLLECIPSLVDLTIHERPIKGTTKNTILTPHFIEQLSFIHDRNSSRCLLPYLQHLFFQAHHSFAVVLFIGMVRSRWIPNSEHTLEMGVNCLKNVKLRLFGLMTQSERMNKVDMHVGALRILRDAGLHFEVSERDYAVQSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP33</accession>
    <name>A0A8H5FP33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP33"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="743" mass="83443" checksum="A2558FE22DAB10A4" modified="2022-01-19" version="1">MLVMIRYNSATELCITKGQEGYVHGWKAKTGKHGKLVLDVLFIKLHKPPNPPAPIKFDGLPENVVPITRNTVRIECKLSDDSEIAISRTQVEILPNFAMTDFASQGKTRDWNVVDIHNSRDFRAIYIALSRSSCADQTLILQGFNTNLLTGGIKNKGGYRQELRELELLDEITRLKYLGILSPSVFGDHRSSLIKSFRTVQGINFVPASVHKSIEWNDSDPLPDTFDSGETWQIISADNETDQKNKRQLKGNFKTAKGATQNETKGRTLKRKAQAEEPERPSTTPKKKIKEDVPAQIQRNSASYLSYPSLRWFLNSCAYDSAIILLYYLYVNHFEIEMSHFTQILSMDLLDAFRSGITDLTAARENVRHGLHNIDSEAFSYGQYADAGEVLLALTQSDLSFSRSQVICTNNHVHKPWKNRTNMLLYMSTRMYQSTQQWVDNFVQPFGWQCQICHTELQTVIEFTRFPKFFLVYVPINASMEIDRMINLIVNGNQKPYDLKAIIYFGEEHFILHIFSNQAEYIYDGIKNGVPHKASILGLVIATRSGGPQALHLMFATFSELFGEVYGFDIGIGGLVYLGLGVGFISATWVGAKSADQMYHYLARKNGGVGKPEMRIPVLFFGSLVVPVGLFWYGWSAQAKIHWIMPIIGTAIFGFGLMTSFLPIQLYLVDTFTYAASALSAASTIRSLFGFGFPLFTGQMFDALGIGGGNSLLAGLAIVLGVPFPVWLYFNGEKMRARSKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP90</accession>
    <name>A0A8H5FP90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000123">
        <property type="protein sequence ID" value="KAF5344545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP90"/>
    <dbReference type="OrthoDB" id="3037695at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="264" mass="29261" checksum="3C43E721D504D59F" modified="2022-01-19" version="1">MYQTISTVCSEHEKLNNAREQGMAALRKQIECLLAEQSGDDKDTNSGGEEAYNSDLYETDSEPESGPVPQVVPPQRVSTPPPSYASGLPQVTQRRSPSTPQRHPPNHQPQPTVTPQRQAVTHTPRGGHRKQWEAYVVYHGWSVGAFGSWRQVEAIIKGDENSVIKGFQSLSLAKQSYQLASTSGVLNAISFQPQTGEPHWVVTQGIHPGVYKTRHEVIRDGLYYGRGAVYPHNNAKDANAFFVAEYMAERVLKLEPAFVITPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPV0</accession>
    <name>A0A8H5FPV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPV0"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31606" checksum="F030AD4A8E5F3657" modified="2022-01-19" version="1">MSTMTLSSKALCRLPLAMFPIPLVDGFLFNMSTTEREFTATITLIRHGESVDNGKSIWAGCTDAPLSERGRKCPSREFETKRQADSLGQWFATNGVQFTAVYVSKLQRAKQTADAILKYHADPKPSLIEEFLLHEINFGKAEGKPYTEKPTLGLSIEEHYQKGIFPHIRNRTDHFPDGESKDDVANRAEKVLQNIFIRDIVGAMKDRRDYRVAIVGHGVFLREFLYALHRRCRIVGPKYDYLKPTAWTRVEIKARWEDLSSDCLPISMKVTHVDQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQB7</accession>
    <name>A0A8H5FQB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQB7"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="25081" checksum="505E75BD4227B041" modified="2022-01-19" version="1">MVLKLYGFDLSSNLQRVAIVLFEKKIPFEYHAVDWTKYEHKSPEYLEKHPFGQVPYLDDDAFVVYECRAICRYLEAKYPDQGPKLAPDSSDIKAKAIFDQAASVEVSNFGPLVDEANFEAIVKPMLFKQPKNEANYNEAIKALDAKLDGYERILAKQKYLAGNELTMIDLFHLPSGARLALGGSDILTSKGPNIARWWKDISSRESWAQVQKGTAPGLVKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR69</accession>
    <name>A0A8H5FR69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR69"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="26318" checksum="AFD1924F5BF92061" modified="2022-01-19" version="1">MTDKPIRIALVTGAAQGIGRGIALRLAKDGLHVAINDIPSKLDVLASVSKDIEAMGMKSSVHPADVSQEEEVRKMVEEVVETHGGLDVMIANAGIAINKPLMETSVEEWDRIFSINARGAFLCYQYAGKQMIKQGRGGRIVGASSILGKAGVSPTLGSYVGTKFAVRGITQAAAGELGPFKITVNAYAPGLIDTQMTRNLDKDAEERYNWQAGDFFKSVPAILHMTMKVALKETYLVQLTINRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV48</accession>
    <name>A0A8H5FV48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV48"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="121" mass="13191" checksum="BD592B84FB09761E" modified="2022-01-19" version="1">MKRTSLRKPPAMDLDLSFLSQRLASQEEEANEPTLNLGAETPALYSPSYSPTYSSGSGSSPSPPLLSSSDGYDDYGYEGHHKNKSVLHEYLREELQRAFLESPSVLAGAEGSGDFSVRSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G162</accession>
    <name>A0A8H5G162_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G162"/>
    <dbReference type="OrthoDB" id="3065285at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61627" checksum="3D83345B880A426F" modified="2022-01-19" version="1">MLWQRLASFQPRVQDIDLQFSRDRIRSPGSPTSSESIQLSELISNVEQDLSDYKEDIQIVENVLLDLKRKKGELERYVDHCKAYLSPIRRLPTEIMSEIFLIYQDLHWSDREDRQFREPLTRPVMAYSSPAMTALVLSSVCKLWYTITLATPQLWSRFSLQIRGKCGSLFHLLEIYLSRSKQHPLTFDVDVNGEGPIMRLLSAHSHRWFCTSGHCPGLNMQTDLPLLQSLEMAYGGAVSLDAFAGARTLRTVSLVGISRFLHSNLPWDQIQVLRARQLSTGDVGLPKYVWELAQKCPALRSLELDFSDYPPRETAGFTSSVHLGKLESLCLQYVMWYNVRELFCLSTLPSLRKLSLGVLGPYDDGPTPDIAVISSFISRSHCSISVLRFTNLRTSMAQIACGMLHHVPTLTELILQESTHSTFHVPAVMETLIAALRISPSPVEVDGHAGESKPALPLLRRLVMEVYADNFPASQFVDMLESRGMLAGGSLGALKLVRLFLQWSDGAEDFNLPLLQSLEAWPGVEIIASTCASRRYLRNEDSERWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1K5</accession>
    <name>A0A8H5G1K5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1K5"/>
    <dbReference type="OrthoDB" id="3263055at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5356624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="33478" checksum="CE4BAF8FB336D5DC" modified="2022-01-19" version="1">MVMGKSKIITVLAVSITDLSTTYSFDADSNVACLGVLSLCQVRLVRIRTFDDLKHLENLSITVNALTAAGDLVLALSLTWLLLRSRTGFRKSDTMIKKLILARPNTFIYICFFFNIGRFYTNSLLATLNVRQSIRNAGDACGGVNATGQMDFNMKMSVLKNDTSFGSINGQRRPDISIKVDTTKELITDASIRTPSPTKSSADCDGIFSDGQSGFDSSEDIDTSTRGYGHGHRPLVPFAPASASTSVLDHISLAPSVISSFPSPPTYTNTPPGPPGYGPSRSSATPRPQPRVTAGGSRVVLSAARSLPASGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1K8</accession>
    <name>A0A8H5G1K8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1K8"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="35176" checksum="A6C513D92121C8B3" modified="2022-01-19" version="1">MKGKLNLLQDLWLSNCIFGEGFDAFEVAHSLATLTSRNGTGSQTPLPWKQIRSLQIRFSTLPIALQELSSAPESIEVELHCCNLRTQRNATHITHDLRSLSIVVDTEDPDVHHWFDWLTLPRLTSLTIAGDKIKRPSYRSVDDSFPSFLSRSSCTITSLSLVDLPISDVDAIVLLSLLPLLSSLTIHEHEARPFKNSIITARLLDALVVDRNNIFSDRRPSSLHTKRLQSLDLRLHATLPAKAISQVVESRWTSDAEYSAVVGVDDLRTVKVLVLRSTNRTVLDVDELLNSLDWIKRAGLQLICASRRSDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1M2</accession>
    <name>A0A8H5G1M2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_008257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1M2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5356626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="582" mass="64065" checksum="6DF457E7472B628D" modified="2022-01-19" version="1">MPVSTAAEVAGKSFDFVVVGGGTAGLAVAARISENPDVSVLVLEAGAANFDHPLITKSSQHAVQFGNPDLDWGFQTIPQKHGLDMIYYWNRGKSLGGSSTINFQCWTHPSKNDIDNWEKLGNPGWNWDMYEKYVDRVYRVDPAPRSQVEGWKIWDITKSSGSGIPKAPNPYHGNPNGVSVKLSTFDPQTFHRCDSATAYLRPNLQRPNLTVVTSALVHKLVLDQSSTPVKATGVEFSNGNINEPFVVNIQREVVICSGALKSSQILELSGIGRRDVLREIGVPVKVELPGVGENVQEHQVISIAFELKADSIDDTWDIFRDEAGYILQGELLAQGKGSHTVGISNLTYTPLSTFTGMERAKELYSAQKARIEEDMKAANVVPGLADQYKLMLESLNPEKDIPSVEICGYPGYISFPKGPEKDKKYYSICMMSNHNFGRGTIHATSSDPSVQPAMDPHYFEHDYDTQSLVEGVRFARKIAETEPFKHAIDHEHSPGPEVQTQEQLEEWIKKGSTTVFHTIGSCSMLPLDKNGVVDTNLKVYGTANVRVADLSIVPLHIAAHTQATAYTIGERAADIIRETLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2U4</accession>
    <name>A0A8H5G2U4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2U4"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="406"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="521" mass="60812" checksum="DF007D719CC52B51" modified="2022-01-19" version="1">MQTIWDQCSFPGNPCYARRERVARDPSSFFPSIFSVCNSAVEPTMATVHPSRMALVPQDSSFSSHNRSKNNRSPSPRRSRRSPTPTRSRNDRDGDRDHGRSDYRDRDRERERDRYRDESRDYDRRRDSRRDRDSSSGKHDTNERDTNRRGSPEYDDYRRTERSEDSGVPGRRPENMYPDRRGREPERDAPPHNDGYSGNYRGRRGGGEVGTDFLDSRRIQRESATVDIWPPSPKGPTRSLSPPRHHRSSKKSKRHRSESPSDTDSSEEERRRRERKERKRRKTKEKEEKREKKRSQHRTRSRDRSYDDDSEDERERRHSKRSRTTTRSPERKRSPSRTRSPLPNEEDEDEWVIKSSSAADSMPPPPVPAYAQAKDERSSYDQDDSDDELGPQPVVKINSSKRIDERAYGGQLLRGEGSAMAAFLQDGTESRIPRRGEIGLTSDQIAEYENVGYVMSGSRHRRMNAVRMRKENQVISAEEKRGILKLQKEERARREAILREEFSELVQDSLKAQGAERPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3C8</accession>
    <name>A0A8H5G3C8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_012522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3C8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5357481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="70890" checksum="CF1ABCC83FA63434" modified="2022-01-19" version="1">MLLAPGLELLVEDVLPRALGLPLLVYGILKLAQYLLAAHDWPSWVWVAAIAATHPVYWIISWVYNQIHRRREAAARGAVFPPRVQESSFKIVKAFSDSALKGYTGDAVHDWSKQYGNTFLLRIFGVYRVMTTEPEHIKAILATQFDDFWKGPMKEDHFTSLLGSGVFNSDGDMWNKVRISDFDVFERHAEDTLSLLAERLGSGVPVDFQDAVARFTLDSATEFLFGKAVNSLDAGLPYPASHSKTTATITTNDFFNHASTKFVTALSEGQEVISRRGVLGRYWRFSEFWQDKAAEHRKSVEEFVLPILEDALENKKDEVVSGEVKEIGDETFLEHLVRFTKDKKVVMDELLNILLAARDTTASLITFSVYVLAQRPDIYTRLKEEITERVGNSRPTYEDTRDMKYLRAFLNEVLRLYPAAFRFQVIELFLTAPLVQNSELSPTTEHPKCPPLFRTKVVGKGTYHQPINLYTLYLLGAFSIHTYSCAYSVFLMHRREDLWGPDALEFDPDRFLDERLHKYLTPNPFIFLPFNAGPRICLGQQFAYNEASYFMIKLIQKFTDLSLALDVQPSQPPKEWIPQPGTTKGRDKIMLKTHLTMSVRDGLWVRMKPISSQVDQEKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5S9</accession>
    <name>A0A8H5G5S9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="557"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1467" mass="162590" checksum="BFE2B72734A7C291" modified="2022-01-19" version="1">MMPQSQDSNSSNDSDAWWAQVPDVTLEEGRQCIPSDPEDSSFSDSDCENSAESCMTPQRKQPGRNTEQPPSTLRKPCPSVTDRPLMLVPETLLHPMSQKAEEEAEWTPSRPGQGVTPVANRLGRINVGGSTPGGPVSPTRQKSTAPSKPIVTDSDDDDDDSDTSTSTYPFEDDDNSSSRQTSWSSIATVQSDSSPSRKRTRPSAEAEQPQSSKMMRTSEKGKAPIPSSPPRHAPLLPDDEMMTSPVHDSRRSPTRHYKRTTSTESSSSTEFWCGPSSVAGPSSDEVNVVSLSSPMEVDRVPSNAFVSTETAAQTTVVTASSISRTTSAESSLFSGFLPGKSGSSAGSNTTRNASIPILTSQELAPGTSAPAIPASSTSNTDANAGTSFISSSPPSVSAPTTSGEQSSIQQLFKPLYLPHHVIAYDERVQALFDDLKKPVPWGTQFMLAAGVTRRDWTWDEVLREMEHFAGKADPEVMHEVQSIMGREVLGSSDVLENIGKEYHREQKAIEENEGRGLGCRGDYEGEENWYGGQIQQIATLVKKPKSKDSNSDSAEFELVLEPLEMRRSSRFTRMLGSRRILQMRINSDFLLSSKGNNGEKSDRDKVMEFLSHKFILNGRVFVVTPPKDDGIYAIEVDEDFGRPVYRVPQRFGDQFRISLGDFLEHHNPLQLNKGQPTSKFFARWALQMSTSIPVIEFEKDDIYFIDDIVVPSVEGKPESHQILTDGCGFINKSALIRIMHQMKYDSIPTAVQARIAGSKGLFILDPHNNETQPKIWIRASQKKIEYPKKIEDSQLTERTRKFLWQTRAHRILDLVHVSHPSPSSSVVSLSQQSILNMSHNGVSNGVFLSLMEKGLREALRPLLEWQGRWAMVQLWDAINRTGRVTGTRLARLAPSVSRAFGFAGREWARGDTGGADDETSISASGAGSVGGSQSADETSDQEKESLGLLDIINPSYTGRDAISGAPASLHERALEKVQAGFNPTYDEDLRDGVRWILKTHIKSYIEKCHFPLPDGTAVEAFVVPDPLGVLKEGEIYFKPSNPIKDSVAQENVDVLVGDVLIGRYPIRLPSDIQKVTAVEVHALKRWTDVVIVPTVHVNNVPEYGQASFMSILSGGDMDGDTVFVTWHKDIVTQFQGERLIPPPKDLEDDFERQVEQVSSFIERLAELPIKERQIAFQQKYLSGMAHFNVGLYSVFHDVAVRTKGYKDEDAIRLAYKFNNVLDGPKTGRVLKGDIFIQDKKTWERDRPPHKSKAKDRLAKDLLAQRPGFILDVLQEAGENLEMQYLQEFDIKNGRHFEHKHNETIRPDPDLRRPWQELQDLRDLGPQSRSDLEAELELVQKHVKASYKAFCNGAASSSSSNNPFIQQTQPRGRKGKTPRKDCMIEAKRIFAGPIDGVPILSKMGNLESIKASCAYDVKGKFGFCVAFHQLCTIKAAASFGGSAPSSRIFDEVKSIPSSCRRLFDRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7S1</accession>
    <name>A0A8H5G7S1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7S1"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5359929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17825" checksum="9B8C9274EF077882" modified="2022-01-19" version="1">MAFRSLVPNTKPPSMLLTTWEGVRRGGKAPEFNSVSYHGKINENEWVVKISSMEPVSDEWLEKVFDGQVTWVYRKEWDAYPVLPPTTEFPPVKVDTGFYYVNAFEPFISTMETETIAARNVVDLLFNEQYGSSICGSRISGSPPLWFPPTLASKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G883</accession>
    <name>A0A8H5G883_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G883"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="75987" checksum="75F0BC28B9E907AF" modified="2022-01-19" version="1">MLNGWHFGERIIHQKHGTDKDPQIESLVFHINGDLDPEHALFHSSRIPFLPVTTLDKEGRPWGSILAAEDGLPGNHFIRNSKYTTLAIRAKVWEGEPFLENAKLFKGGKEGEERMLIAGIGLEFSTRRRNKLAGWVSKLEQKDSKVFELELIVNQSLGNCPKYITTRQFVPYLNTKPSIKYQKPQLPSGSRLPDEVIAFIHNSDTVFIGTTYAAPTEDAKKYPSHVGMNQRGGRKGYIRVSPSDGRTVVVPDYSGNRFLTSLGNIEASPLASLTFVSFTTGSILYITGEAHNHVGEDAKRIMPFHNGTLSAVKTTGYTFVEDALPVRLAPGSSENPSPYSPPISYLADEPQSKGTKLFNNSDSERTTAHLSRIQLHSPSIATFTWETSRPIEIEPGQAIIMDFSTLLGQKQYQHMANHNPKSVNDDRIRTWTVSSSSSWRSLASSEPHSSSSPQSYTLTMREQPGGLVTGALFSISRRIAETRPELLDDPRPLDIRIGIVGVSGGFGMPKQVGGDLGVKKFLWIAGGIGITPFLSMLRAPFTVRDGGEEGTIATEWDVRLILSTGNPEVIIPLILSAYQDGVGKFHQEAGDAVQTSKSGLSRAKAIRLLIDVYSSSSSNTLDLESLQAVEGINIRMHTGRVPSNLFSSTVKEDAWGERDAYLCGPKQFEDVIVEDLVSAGVVGMKRETFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA23</accession>
    <name>A0A8H5GA23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="2009"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="675"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1161"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1242"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1324"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1461"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1514"/>
            <end position="1731"/>
        </location>
    </feature>
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        <location>
            <begin position="1745"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1942"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2261"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="98"/>
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    </feature>
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        <location>
            <begin position="105"/>
            <end position="149"/>
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    </feature>
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            <begin position="151"/>
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            <end position="1334"/>
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        <location>
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        <location>
            <begin position="1462"/>
            <end position="1474"/>
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            <begin position="1532"/>
            <end position="1547"/>
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            <begin position="1555"/>
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            <end position="1708"/>
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        <location>
            <begin position="1755"/>
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        </location>
    </feature>
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        <location>
            <begin position="1768"/>
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        <location>
            <begin position="1840"/>
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    </feature>
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        <location>
            <begin position="1944"/>
            <end position="1953"/>
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        <location>
            <begin position="1963"/>
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        <location>
            <begin position="2264"/>
            <end position="2282"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5361144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2282" mass="239626" checksum="F87995C774E465B8" modified="2022-01-19" version="1">MDPAQLSRWTRFAAKGGIGKCTATHDCVAEGEEDLMFMKDDMITVLMQIPNLDGVYLGYCEGVVGRFQAQHVHFHSKLKKPVKAKRNSAASSRPTSSSGTLHAKSPTPSMFSTSSPTPGTPLTPTRPAHSPNSVSPNSPLTPNTPTFTNGAVGNTNGSANDHTGSRESKRASMVYTGPAAAAGSGLSTQSSSVKPSTPMVATPEGLLYLESLAASTSTTSTLNAVSVVENPQDTVSSLSPHSQPVQSQHAPSDSVTSFASSVSKYSSSQYSSHSPSPSIASVSTTHTAQTSHTIASVLSGHSTQTASTLDIDYGFPRVLSPNSMHSASSRHSGDPNINEAMALRPARKASIGALSRHPSTASSSTMTSTSSSARGKARKPSTDSYNTADASFLEEHEVDEADFEMVGPGRAGLHPATAIPPSTSGFGLGTTQPSSTSISTSASSPKLSYATSVPASLARSTSSASSVFETANRSLSRSGSASSKPKAPLSRSTSQKSVQSIASATSDGEIGIGLSLLASLGEGSSDDEDDEDIGDETLKLEGKSLDIDDEDTLPNMGLSYTQPIPSTSSTSVPAASANLVKSHSPTPSYASSSQSHSTYSDGHSPIPGDAVAAFPQPPQVNEMEVRRLSRMRAQQQSPEDAYEANQAARAQQAQRNLGSAMGGASGFGRLLSSPSIGSLRSQSTVSAARHTHNPSEASSYSHSSSSSSGGTTTHPHTSIGSGIGNGNEHAHPSTPPFSNPATPNAPSFSPFAPNFTSLPSSESSPKASPTSAVFVPAYVQGNLPPSPGAFSTRSGSSYQSNGEDWEGASDIYDNYFYRYSVASKMSGSRMSTMTVNSMRSRKQSATSVSAMPSGMGRKPSDYGEGEGAFPAGAAVTAAAAAANASTSSSTPPHLITQPPLHSLSLATPSDSPTTSLPAASPLSERAPVSPLSTASSSVNSHSGADDSPQMPSEIQPIEESQRPLMSRQNSLNSTALLSNGETVSNSRALSRKLIAVNGVDGEPSDDDESVYSDSEAKQRPGRFTMMEEHAAALISPENTRVHTTGALNIVKVSTPVLGSGFGSDSESGITVGVVSPVLRDASIPLTAAEAQARLAASNIISSSNSSSSLATLSPNLVNSTPTKTRPSPLDLENPTRGSIRNDGQSQLSGHSIGPSPLLHTRWGSPLSSAGFSSGTASVYSDGTDTDTNLAGGIANLLRQRSQKERNTILEQGEEDDHGERSMSLDIDGERFNDLSLVTAMDQSTTSTADESHAGNISRDHPSERGLVIEDDEELPEHAKNEEVDLSIHTQESIQPLMESGREESEGSLARRKSLSRIIIDARSSEQSLQSQTPQIGVISADNASPKYPSSEASPYSASDLPLDLLPPPSPSTFPPTSPIASQGQVSHLRPTLNELRGYTPGQGERQSLFMPHPNAPKAPTDNHGMGPMFIRGTMSPSPAQRAGPDPRKVAANVLQMVLASPSPQPSNIFPPPSSAPIRGANGRTPPPPPPTHLGPTIYARVDVDLATSTGPVPVTFSVQPLGPPPLPAMPMQRTQSTPLAQDQQVVSLNDDRRPPPSPALAPPPSSGFRPQASGTPPPQGRNSPFQGAVPVSGRDSPVETDLDFNASRSPRKTPTTLASPPKTQSITPSAPEPSRPSGDIIQPRPRSRSFSAFGFKRSSSSTSSSSVPALPTRDNGTSPALRSRGSSTSLTTAASSAPPSPPSRSLLTKQPSNTKLRAAAGPSPLSLPQNNITLQAGIGGIKPPLNPLPSANSPQTAVFPSSLRKVTSASSLRDSKSSSISRTIGDVGSVSPPSSPTARRTSRKQSMQSATSDVVEPQSPKSPTLMPRSLAGDSEIGSMRSMTVSPTSTLAAPPSLHTKLSLPNLQRLPPPRHDSFSSMTALPSPMSTEPETVQVQDMDFELVRPTLGFAQASGRSSLDSNFSGVARGSDGRPDLSTFLRAESPTVSIASTGSRDAVPRSKPMTKSSSDNEANNESHRQREQKWMTVMGSVPPSQSRKSKKVRKLVGEGVPSSVRYLVWSHLTDCKAKNVPGVYANFVKRAKVPSFQDIDRDVKQCFGEHPHLQATEGPLLSLLQAYLTMVPDVQYATGLTLISGQLLLLAPEEDAFWIFVTMMDSVLRPYFSPNSTQLEVDAALFSRALEANDAQVSKKVLVDMSMNPANLCSPWFCTLFVGVIPGDYVTRVWDLFLYEGVPFLIRVGLAITYCCRRAILEATSEAAVLQYLKRPSATWLPPSPEAFVTLALSFKVKDDDVRKQRVKMEAQVKRQTQAPPRTSGNAISLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA48</accession>
    <name>A0A8H5GA48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA48"/>
    <dbReference type="OrthoDB" id="2596754at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="230" mass="25351" checksum="BF7D00E9C58049EF" modified="2022-01-19" version="1">MEFGDYSPPASTPTRDIEKATLLKIYAMKLFLGTLEIDLVKADLGLSAVNPKKSAEGGWDEVVVVSRVLERLSSSSSKRVTHTDDVDVYFSLFLLSLFVFIKKGEKVIHDHTDADTDVLMNCNPCSSHSPFHHFNSNSLFVNDPPPLTIITTMTTTMGLTPSSTLTPTTPLTTHDNFMEEDEGREAEKDKKSGRGLGRRRTGGRERGRGKRPPPTNHLAPPRTGEVVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAC1</accession>
    <name>A0A8H5GAC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAC1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF64">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5361120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="66931" checksum="2D03E212D899B583" modified="2022-01-19" version="1">MYDFRTSDIGRLPTERGFPATLRLGCFFRGEMTLQLLQRKKTQLNEAEEKKSPAEDHNDDVDSELVLPKMASLVIVLLSNMFMQISFFIVVSSSNEYAKHLGGTSTFSGVVIGIPTVFSGLTLIPLMKYDRGGYKIPLHVCCASLLLGHIFYALAYHFSFLYLILIGRCVNGIGFSMWMYCKRYCSDPRIVGLRRRTLLASWLMTGNGVGMGIGPLLGGILYKYVGFDDPVTQNANGLKGSLWNGFTSPAWLLAGMWVLYWIAVCVWFEDVEKNALPLGSGKGDEVQGQQRSQPAKTEGSGSGSEEVYVTATAVEDSSPSRLPTPIPISRPGHRQRQSQSEENPLEAPVAPTSTANPATDRISSSRYPVIGCMCWFAMACFFILGAWEANIPVYTSPEVTPELGFSPFAAGNFLSLGALICFPFFIGNVFLARRVQDRWTLATGTFIGGSALVIFLILLGLDKTSIGGISPPHSLLTNSSTSMSTSTSTIYDSDTSPIREIGLASAPALFVCWFLVALGFNIASTVTMSLLSKQLPSTPRWNGISSLVIQYSNYTGRVTGAVWGGYGGGIGGVGRGAGVLTAERIRSGMMGYVGLELAIVCIGGVICGVCWRQLKAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB40</accession>
    <name>A0A8H5GB40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB40"/>
    <dbReference type="OrthoDB" id="3034033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="541" mass="59403" checksum="CF9A17F930C8DD61" modified="2022-01-19" version="1">MPSSTNTTYTAIKAERLFHLSSILRRAKERQNTITVAFRRTLQPSHSARRRANQIGLSINITKAVNCPQGAVSRELLPVLDFTPIPGEPIPRAASEELRGVYGHSVTHVHPIGHGRPNAKPKPVIPRIVIPSVYDARRQPRPSSVPMDVTNDFDIHALELTGLSAQPVSASQSQSSALSFPSAVTDPLAGAPSALRYSTHLNPHHDERTSTRFPRPSSISSTTDPILSHVHDFKMPMDHLIRDCDTIAKPTVSYATAPATRHDSIRDEPSTRAYRHSYGAAQPSSSMVAATDFTGTHNLDSSFYTAGTGVTRAAPRSVDSVYETGTRIRPANHRELPSNRNRHRLYDNDSNNERDNHPLMEMEVPLFSFSDAICEVERTRDSDNEEGYWSASESIESVSTGSQYSQPSATCSNDGTSSSSSSSSEPVTPVDLDLDMDVSPLNLPSPPQGLRAKRKSADSELFNEDDGFWFSFGVDDLDGYDWDGPKPPKYIRKQLNWSQSKHTSSSRHSRPRSSPSDSLDVKVVGSRSGQSPLTFPVSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GBH4</accession>
    <name>A0A8H5GBH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GBH4"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5361690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54663" checksum="B939E1D9C0DC777A" modified="2022-01-19" version="1">MLDGEKYDTSDSGSQGEVQRYERPKGIKGLYYHPITQVSLLGLVCFMCPGLFNALTGLGAGGQVDSSTNSNSNAALYSTFAVSAFFAGSINNKLGAKLTLLLGSFGYCLFIGSYLAMNIHADAGGFVIAAGAILGICAGLLWTAQGSLMMSYPTEAEKGKFIAIFWAIFNLGGVVGASVSFGQNFHSTSNRVGNGTYIGFLVLTAIGITLPLFMADPKKMIRTDGTKVPIPLEPSWKTQIYGLWVALRTDPMIVLLFPMFFASNWFYTWQFSGYNGAIFNIRARSLNNLLYWSSQIFGAIFMSFVLDSKRLRRRTRAFSSWVILLLMTFIIHTWAYFYQKFVKLLFILQAVADRLDRDYTRATYSGDSERIDIYDAQYVGKAFLYVLFGIFDAMWQSTIYWLMGAMSNDPAKLAYFAGFYKAIQSAGNAGIWRADAVQLPYMNLFISTWVLLVAGLVFALPMIYLRVKDHTDASDEKVAQLEAEADARKGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDW7</accession>
    <name>A0A8H5GDW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDW7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="213" mass="23946" checksum="7AD3FA93939CC515" modified="2022-01-19" version="1">MATLHPILFGSLTVALAVIPIFFQQLPRYARLRIRFFLPSFFDENARIASRILSRAHQIRNSPTFTRYNLDHADFRERWDNGRYIVFEEMGDDAAILYRCILLREVQTDDSDYWNAVAVDCALILETMANELPTRSPSGPTHRIDANVATPTPYVLTTDVQTLTHHPAPSATSLSHTSAISRRSDDTVTPETPPTSEAPKPALVITDIRAPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE68</accession>
    <name>A0A8H5GE68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_008368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1149"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1414"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="97"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="812"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5363146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1448" mass="161339" checksum="96B8BA406D1D08BA" modified="2022-01-19" version="1">MAAKVGGVPEELELSRPGSSGNTTLGNDGSSQNETKAQDDAFDLERLLGLAVEKLDQSNLPLRSLGVSFENLRVQGIGSEASYQSTFGDILNPLRIVEGINNARHPVKRDILTGFEGVIKPGEMLLVLGRPGSGCSTFLKTLANQRAEYHSVEGEVHYDAFTPEEIRRQYRGDVIYSPEDDIHFPTLTVNQTISFAARLRAPASNGGRLGLSRNAYADLLTTHLLSVFGLTHTKNTLVGDAAIRGVSGGEKKRVSICEALAARARIVSWDNSTRGLDASTALEYVRALRTATDLGKMTTIVSLYQAGENLYKYFDKVCLIYEGKLAYFGAASSARQYFIDMGYEPANRQTTADFLVAVTDPNGRIPRSPSSTIPIEALMAPAPKTSAEFASYFQTSHLAELNRNEIQAYKQEFVTSDPARIREAYQRSVKSEHVRMSRKRSVYLVSLGLQAREVMRRRLQMLKGNWVATFLNAFSYVFQAIITGTVYLKTEQTTAAYFSRGGVLFFALLFAALTSMAEIPSLFGQRPIVLRQSQWGFYHPFIDQLALFLVDLPISAVTITVFGVIIYELVQLQQSAGQVFIFLLFIFTVGLAMKGFFRALAAACRAEPVAQTLAGIVILASVLYAGYQIPYPSMVGGLRWISYLNPFRYAFESLMINEFRTLNGTCASLIPQGPGYENISLANQVCITVGSIPGQPTVDGNRFIEMSFEFVSSTGRIWRNFGIICTFTVGFVGACLIFTEVNTNLSTNAADSVVLYRRESLFGRKRQRPSARQSDEEIGSNKDATIETVPVDNEKHAKASLQELDLSMTEVFSWQNVNYTVPVSGNKDGETQRRLLNSISGYVKPGKLTALMGESGAGKTTLLNVLAQRVSVGVVTGDRFVNGHDLPKDFQAQTGYCQQTDTHLPDQTVREALLFSAQLRQPVSVPMEEKEAYVDKCLEMCGLQKYRNATVGSLNVENRKRTTIAVELAAKPKLLLFLDEPTSGLDSQSAWAIMRFLRELANNGQAILCTIHQPSGELFQVFDRLLLLRKGGETVYFGDLGHNSTTLINYFERNGSRRCGEDENPAEFMLDVIGAGATAKSVIDWYSVWTSAPESATLQTEIERIHTEGREKPAVQTALHTEFATPWLYQVSQLLKRDMLSHWRNPTYIMAKFVLSIFSGIFVGFSFYNSPFTQQGTQNKLFSIFIATIISVPLANQLQVIFIKMRNIYEIRERPSRMYSWTALVTSQFLVELPWNIFGTSLFFLCWYWTVGYSSSRAGYSYLMLCLLFPIYYTSIGQAVAAMSPNAEIAAVLFSLIFSFVITFNGVVQPFSQLGWWQWMYRLSPYTYLIEGLLGQALGHEDIRCSDVELVRLDPPSGQTCSSYLNTFIETKGGYITNPDATSSCIVCPVSTTDQYLASSFNIFYSHHWRNVGILAAFIIFNVAAIFAFTFWFRIRTKSIAELLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHL6</accession>
    <name>A0A8H5GHL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHL6"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="548" mass="61700" checksum="E10F029386EAD6CD" modified="2022-01-19" version="1">MNITSTHQALMIAELRQQIFFYLSSRNKSLLACALVCHQWQDDALDYLWKRITSMEFSRALGPIRKRTPDDPNDQMTVFEETLGLDAWRRFERLYSHRVRHLDLAELRLNQYYCILTTMASTRPPSSSRIFPNLREMSVHGSGLLLPTSGFETKVVQFMHERIESFSLYGNGKETLELGFPSMFTIKAIGDYMPRLTTLVIDLYYCAFDHRFTDAMAICCSRLPPLVDLDLGPVVNEPDSYAVVIESAACNCPCLEAVVVGGIGFFPSSAIPVPMPSLKKLEVDESVAIHTLRLLQQYPMPSLQELDLTSLMERASLAEYQNLAMHIVTSFPQLTTLNFNISLSAHIVPCRGDEVNPFTDEDMGFLGRCLPALEILGFDFCCAQDVKRPTLQGLSNLAEHALKLQSLNLVILPTHPAASNTNSDQGLAMLTSGSLSSMNRFRCLERLGLGDSHLHPKWTIVVLEVLGYMLPLGCDLRIPALDYDLGGPDIIQSNKEWEKVISGLRNRDPSRNWVQFKELWRATGLEKILAMYLTTALQNLQITTELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHU1</accession>
    <name>A0A8H5GHU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHU1"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="45996" checksum="CE37C620C3D2C3D0" modified="2022-01-19" version="1">MGTLNYSDSSDSDASAHTATQSPIATLDNSSTSLPFPSGISPELEPHELSSHMDDRIAQLEQASQEHTAKLDRLLSIFENSPPPNTTQPPPTTVNDDPEPSSHHSSSLSHAKVSPPSIFDGLRSNGRVWWTSVVIYASTVHFVNDQAKIMWALSYFVSGHAAVYRQAVLNHNTLFGKPHFTNWAEFEADFAKEFLPEDDCVQASLVLEGTSYFQGNSSVDNYIDMFRSYVTLAGLNVEPVLYAPNLSDPVIAGRLPDARNVGQTVVLKFCQGLKPSVERKVAEVESRPLKWDIMGWYNLAKHFDKHEHEDAAIRTVQGGSCTAFPSKASAPVCNAPVGRSLFPVPIPASAPLVPQPAPLPPGVPMEVDTAWGKVLAKRLCYNCGKAGHLSFVCPDCRHQDVRAVELDVNDWAEIAEAYAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIN3</accession>
    <name>A0A8H5GIN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIN3"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="740"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115932" checksum="F649FD051C4E7577" modified="2022-01-19" version="1">MSHALLLRLFLTPFFSVHVALQYLTIYADNVGVTYYITRRLRELDILELRDVWGFICHLLLTRPSRSRALECFVIDTAQRSTHIAMVTLWFMQAALKDLSGHPHNSPQFMTCQRVLHRCHEIIFGDLPQTVAPYSILNLPFQSRFMRKKIKHHRDPVIVGIGMVLAGAPALPQLTEIMGQVAIEQGRVEETGSEERSIESSEDLASPGGAIVDDPEEIATDADDGSVEESPTVGSAPPTNNLRQFNPGSLGRRNVVGAAQTSPALPLYLHGIRRSRNSEDPLGQLDAEQLATPSQSSPSISTSRPTPRTASLNYADTILQNYDMPSQIHLLRSNYCRSEVGGSSLPLIFSNSPSWQVSFILTLENICDRLLVVPRPARVSALRAELTSLNHKLPAEVCMPMWCNSADTPQSSRIPHPHHRIVRIPPGESVVLNSAERAPYLLYIEILNDDLDFDPQKRNNKDLLKKIVLKENERSTSSRGLDTFSSPSSSQLRKSLPIHDDDVAIEESTVVTPAHPLITPPTPTSAPDEEEEMDLVEQLYGPDQSLRSQAMDLSDSIVLPPPPKNKDLDMAACSSPLPLPLAPNESTNSYSLSLDEYSERMRTAAIMLAQLNASLVRDLINSTPANAPPESSSGPLSWIPGSAWLSGSTDDSTKTTSPSRYGTGSQDLGKPAPSRMRLQPAEASAIRDRIMNEMLALEEERMSHMRENREAESIVKIGDISGGLKTAEDEGIIRRELSKADPSAMVFSESWATKKSRIRHGSPYGHLANWDCVSVIIKTGGDLRQEQLAVQLIHEFQRIWEEESCACWVRYFRILITGGTSGLVETITDAVSIHSIKKAEYARRLAEGRLGHVTLFDHFKNTYGDPSSAKFARAQKNFAKSLAGYSVVTYLLQIKDRHNGNILLDRDGHLIHIDFGFMLANTPGNIRFEAAPFKLPPEYIEVLGGVNGAPFLEFRKLFREGFEAARKHCDRIVTIVELMQKDSTLPCFAIFGEQTAVQLRDRFQPALTHSAVGELVDRLIDSSLGSHWTRLYDTYQYYSQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJM3</accession>
    <name>A0A8H5GJM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJM3"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="265" mass="29546" checksum="BEB66AA38297D59E" modified="2022-01-19" version="1">MSVRPKSIALLICDTPLPSVIVEHGDYHKIFSVLLKKSLPDHDFILDSYDVVHKMEYPDDEKLDEYDCVMLTGSAASAYEDKEWIHKLIDFVKRIADTKPNIKLVGICYGHQIISMAIGGTCVKNHGKWEVGPTAMTLTELGKDLLKMPGDELILQEMHQDYVPAIPPNCHLLAFTSISPNQGYVRFTSHQPPSSGQVDPSSIQILTVQGHPEFTQGIMDKLVVARTEKGILTKEMKEDADKRSVLRNDGVIVAKAIWRVLGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKE1</accession>
    <name>A0A8H5GKE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_008971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKE1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5366603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="664" mass="73792" checksum="B024EBD761C4F97E" modified="2022-01-19" version="1">MSFTKAFSPAIRELRILCSQTGPQSAGTRQFILNRYATIKDLNPDLPVLVREADGTPARIFARFVPHAMPGLQTDTAIHEATNREIDVKKQHFEVDSSGEDDCHVADGVHDGLEFPTEEERLTLRRVSDTIPWPAYLICVVEMAERFSYYGCSVVFTNFIQQSLPDGSRTGAGGAEGQAGALGRGQQTSTGLTTFYQFWAYVTPILGGYLADTYWGRYNTICVAIAVALVGHIILIVSAVPGVIEHSDNALTCFVIGMLVTGLGTGMFKSNVSTLVAEQYKRSKLFVVTNAKGERVIVDPAFTVSRMYLYFYLFINIGSLVGQLTMAYTAKYVGFYLAFTLPTVVFLICPFVMWIGRNNYNRTPPTGSVVATAFRLWTFAAKGRWSANPVRLYKNMRADDFWENAKPSKQQERPRWMSFDDQWVDEVRRGFKACSVFVWYPLFWLCYGQLNNNLTSQAATMTLNGVPNDVLSNLNPISLIIFIPLCDFVFYPFLVRKKIRFTALKRVTAGFFTGAAAMVWAAVVQHYIYETSPCGGHATECDEVSPLNVWIQTGSYVLVGFSEIFASITGLEYAFTKAPKNMRSLVMAMFLLTSAFGAALSEAFLPLLEDPLIVWNYAVVAILAGIGGALFWLSVRHLDAQEDLLNNLPEGHMRAVATGDSEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMP1</accession>
    <name>A0A8H5GMP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMP1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="840"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="900"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5367470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="995" mass="111167" checksum="3FDEE0F8526A5605" modified="2022-01-19" version="1">MSNHFQQWNTQYHPQPEHTYPSYDQTSNDYSYPSEPSQSSLYASGTRSDPYMQNPNYQQPQQQQHPTLPTSYNFQPELFRDPNRILPSSSSGQVHHPTTSYIPSSSSTAKRQRVHEPVDDTKDEDVDTDAIPEQKEGNKGKPGACARCKSLKVRCEFKTDTDPCKRCLNGGHECVIPGRKKRRTPPKREHLLAQIQKQAEEIEKLMAKLVATEASNRDSRRTSTEDLCETVSPDFLSSTASQGTLTVPSSANKAVEDWFAKARDSLTEFGGFIGMGGASLPKSYIVDPDLEDSSDVEDSDEYSDARSDFEDNNYVISTVESDAEEVESGRRGRGTSVSSSGSGQRAKLKGAKKGGGRMATLPSEAAPFGLMAGLSLRNKKRSDAGSDVGQEEAAEGENGLGVANADFFRSPTPDPKSTSIDAVPQAPHILARGIITPEEIEPLFKIFFDLINPSISLVDPVLYTPERTVYRSPFLFTVICAVSSRFYTERPGIYMQAMHYAQFAAGSALIGGPKNVEMVMAYIILSLYQLPFKRWEDSRGWLYLGLAIRIATELNLHHPVTAKPQNEFHAREMLNRTRVWLNCFNLDRSTGSQYGKAPIIPDTDYLANHSEDWWHSSPWNMKNFDVHLICYQNELRVMAGFVKKIYSNPEHPTGLNKEVDFERLAAETDEELQQLEERWFPILDKNVDPNDRQGLLRTGLLKLAFSYARLIALSYGFQHAFGKNNFNENPFLMRCKTAAFDVVKAMVENLAQPELRIYIRHGPEAQSVFTTFAAAFLVKLLQPKFSSYLDDHTRQEIRNHVQSVIDLFSSPDIALDNRHGPKLYARFLKGLLASPMVTGVPRRKTHHPLSSSMSSSSSGRQSGPHNHLNGLSADHPSPASSHSLSPPPSHEAMSFDHFAPTSQGAIDPFQTSMGVDPSHSSALPQDDFGMGQTDYNPYQQQGLPLPDGDDLLRMHSISDPANWQGMAVPSYNWLGQFQNEMRFNMYGQNAQYMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNA3</accession>
    <name>A0A8H5GNA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNA3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="483" mass="54430" checksum="4B03A0B5A891D7DA" modified="2022-01-19" version="1">MNSVGSYHTGGQGSHATVNKSGEEKEDSEEDIPLCHIVRTITLPVKVKDTLEKPPTPTSRSLDSGDGAGAQIRETRSKTQSEEIEKPKALKGRKNASRATGQTRITRQTTDRISISTTTSRMKAGRDDDSKGEKEEADRTDWRRGKNSSFSDGSNEDEDEHLDQGGSIDECTDSGKGKGKAKETEVLELSEYRDLDALKQAFTREIRANKLSLEYVKKWLEEHPELPCSACLKAKRPCIPIQRGMTCMDCSRQGQPCSRKVWERQERIMRKLEISQSEYDQLLQWYKGHKKDHKDGNGDVGQELQTRDKKRKEREGEKRVEEDRKPASKKLKIPGGQNNSWRNLHSREKKILAEEDIQEEQSSSATLATGSKEPFPIPPPSAVSGNEEILVDLARRSLNDFIAGQINDYRALKALQRNLSSLADKAQNGEQYADGVIEDLSQYSRQVQMMQDYKSMMKSYVGFTAYSFISPENEESLHRSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNI8</accession>
    <name>A0A8H5GNI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNI8"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="6">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="109" mass="12232" checksum="5BFABE96773BA80B" modified="2022-01-19" version="1">MSRWITNALEALKDRNAVKGGLKRAGIRGFKIINMFCAIHLFTEYVGRPSTMAGPSMLPTLATHGEIVIEDRITYRLNPSSLSRGELITLKSPVNPSHIVCKRVHWSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPV9</accession>
    <name>A0A8H5GPV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPV9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="163" mass="19131" checksum="0488676C734C7220" modified="2022-01-19" version="1">MSPVTHEASSSIVQGALAWLLSHPASAASASFLVLLVVLLRRRYPCLTLPALEKSFKRLEDAIQTYQGECPQHYYHEFHDGFLILRGDVRSLMYTYFYGHWDPVWTLRYWKSRMDHIREVVACYERCEDMHRSIQHAIEIYRQRQDSLLLGFYNHTEASAYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQE8</accession>
    <name>A0A8H5GQE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_003028</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="1386"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="1419"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="17">
        <location>
            <begin position="2226"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="2431"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
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            <begin position="2736"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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        </location>
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="2305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="2352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2498"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2573"/>
            <end position="2620"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2650"/>
            <end position="2678"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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        </location>
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        <location>
            <begin position="1888"/>
            <end position="1901"/>
        </location>
    </feature>
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        <location>
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            <end position="1955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="12">
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    <feature type="compositionally biased region" description="Gly residues" evidence="12">
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5368980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="3024" mass="336344" checksum="BD51B9D6BAE28C83" modified="2022-01-19" version="1">MCTRSLRPQAPVKGDAQQVQITRLPFAMAPKSAFNLEELENSIPQRFDEAQSSLANHRKNCVALYKLHTQASKVIKPGKNGNSLKLIGEQLFGDVFIDMVNRVMLVKKGACADRIVKFVGAYVKFVNDKVIEDKEKQGPGASASSLTLDDDDTFASRFVSRLLEWLLHGFSAKNKIIRQRCVHLVSEMMSNLGEITEDTYNLLRENVIDRLYDKEPVIRAHATIALSKLAGTEDPDELESGESTAVELVLEALSYDSAVEVRRAALINIPVTPETLPLILIRAKDTDTITRKLLYSSVLSTKVDHPRRMTIAQREDLVKSGLGDREPAVRVAAGKMVTGWFDLCMAELEAPDEGAWVGDDGGVMRTFVRFLYLFDVVGPGEAIAVDAVLAIFNTRANLSNVFVFSDDFWEELTPESAVLARIFVEYCHSQQDETHLEAASLPVVTAFAFRIQEAYNNLLTFLQETELLQAEDADEEENEEREEELAKREVILGELLRIALKLDYMDELGRRKVFSVVKDMLAHPNLPPGLIDRCLDVLCEVLSSEKELIRIVVEIIIELRDEDSPELGFDDDNDGSRSDISSFRKEKSLRRAKEANQMTPEERRQADSTDLRCLTLCIGMLERVNGTFDDNSTLEGVLADLIVPVVKRKELALREKGLSAPEELKLKMLQVVFDLLIMYDDEFLGKSEEITLESEESDPVQSLISIGVCKLLLSGQITDTRRFIKGYQVLVSLLITYISPATAENQELRQCLAYFFPVYCYSSSENQKRMQSIFVRAFDLAIKVHEQLEDDQDMISVSQFGLLLVDWTDPNKLVKLPNSEHTQPNAHDELAVEILLALYDSDRDAVAQGYGIFDDDEAVDFTRAPSDNNPASDKVFNKFKERFDKTYLAKVEAVEVKTIVRDKMYRDLYEFVGLKVPEVEEDEDEDEEHEEEAREEEKEEEKEEEKEEEREEEREEEREEEREEEEEPSSTPPPATPVTHAQDLPEDSGEEASPPLRKRAVSAEPDEVQHDSDEDSDAVRASPPSPMKKGSKRAPPTPSKKAPASPVRKKRGTTTRSVGSRNTKAKAPIEAKPKAKQRAEPTLNNRSSGTRRSTRARKSLEDDNDSSPKAQAEKPVKVAKRAAAAKTRTRKRLPEPDPESESEQSIGYSSPQLLLNRPYVARSTFPFTTMSQWGQQPGFQYPMQTGFPGANPQFQQNPQAQQPNPQFQQQNMQFQTGFNPAAGGLVPQRTGFPGQPQGMMQPQQTGFPGSGFLQSQPTGFPGMQQQRPAPAPPVPPMPSQFQQQNQGNMLSQPNQANRFLSPSPAMGGAPMARPLVAQPTGYIDPRLQMMSSTFMPVNTTMPYNAGGAPQLPSQVLDSGLNLQQSFQQHNQGTAPPRIPWALSKGEKKSYDNIFRAWDAHGTGFISGQTALEVFGQSGLSKDDLARIWTLADVDDRGKLNITEFHIAMGLIYRRLNGNDIPDKLPPELVPPSARDLGDMEESMKRMLQNETRPGSSQDVSRQKNRSFYSNTTQDPGRDATIYKHPDGGSSDSAYQPRSRHVDRKMVRGKYDQGAAGDLAEVKNILDNTSHMLDKSAEEEASRTAEDEALDTEMEDLRYKVKRLQEDLDYVSRGPRSAAKDEERRRLERELLNIKHEKVPELERKMKARDERKEREKRQWIRDRDRANDRFGRYNDRDSDDYYSERYNDRERSYSRGAYEEKDRDREWERDRERERERERERERDRDRDYDRYDRDRDDRRRSRSRDRYDRDYDRPRSAFRDNDRPPRSPPRARSPPRAPSAPPNNAREPPPKPAASPAPNMKSMTPEERQAYARAEAQRRIEERKARLGLVATPSPATADTSVEDRLQEQKKAAEEKARAAEKEAEEREKMRRERLEREKAFKEGRDVPSVSPSTPTAPEAPSAPAPKAAPPAPAPKAVPKKAPAPPPPKPRNVPKAPPAVAPVPAPAPPPPAPVVPRVDPEEEAFRAREEALRKQREERAARLRELEKQEEEARLEEERMQARISAMRRPSPAPSAPQVVSSPRLAPPAPTPPVPAPAPAPVVSPPAEKSSTNPFSRLINQGAAASSPPPAAPSTNPWANAGAAAPPAPTSAPAVPTPPPTVRSPSVVTIPTPTRSPGPKTYNTAPADTDDWEDIEKNEDDEDSDDEITGSRSLRNEIANKLFGNLLPRPQSAAGNDSAPGSPATSAPPPPPPPPAAPGAPPPPPAPAAPPPPAIGGGSSSGAGDRGALLSSIQAGARLRPTKTVDRSGPQSTGKILGDSAPPAHINTVAREPSPPPPPPPAPAQVIPETVPMDLQETSNHSYRQSVDWYAGLAADSGTATLDKLPSTREEDESDSDDEPEQPEALPGAVPAINIESVGESDLMADIDKSTVLRVRSLYAFEGDGPEDLSFAENIMLTASPSKTGGDWWFGTLLTSGKSGLFPKTYVEEVHPVKAKAIFTYNGENPDELSIVEGEIVTVVDQSEDAWWKADKDGAVFIVPAAYLEVVEAQISDQAMVEKSSNTEVLPNEITSVDTPITEKHPYEDDDSDSDDDSDSSSDFFSLEGGGSESDEELESKDDRLAREREREMVLEAAGLIVKQDKKPPPRPVRRKSKRRPPPTAPQRPSIGSIKELPALPEDDPVDHLTHLNDAFDRYEAFKVAQGNSSNRLSIASTDTVPPSPTTSTMTTSTVTNTASSEGGRSYSAILNFLGRKTPSEVEKRTLTISGPIHNTNDMSWASLVDKTALDGIPPNERKRQEAIFELIATENAYVSDLQLIVEVFYSSMLPMLDKKAITVVFANIEDILLTNITFLSVLEERQKECRLYVDRIGDILYSNMPNMGLLSFNQEYCVNQANAIKVLQSLRDSNPELAGHLQVLHYTEAGEEQESVLHSLEVAEKILNHINESIREQEGHEKLKSISQNLWIGQGRLDLTAPTRYMGPRRLLKEGILMKAKSGRKLQAFLCSDILVLTDDKLRNLYRMPIALSEAKVKDLLGGRVLITFLHLDDLSFQVSLPYPRGGEAIALKATSVRDCQRYRIGKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR63</accession>
    <name>A0A8H5GR63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR63"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="22858" checksum="9E75ABAE93EDCF2E" modified="2022-01-19" version="1">MSSSKDSGSSTTQVVQEQVDQLADQNVDSTDTELRYMAYGARLRTALRASSRYIAYTSDIGEAFRPVVPPWVVTAAYGVSWLYLTGDVGYESYKAHRRGPTALEAAHFSENTRIALTAVQRATFQSIASMALPAFTIHTAVRQAKKAFVNVKNPRLKAWGPTMTGLAIVPALPYLFDHPVEVATDRAFDWIRERLAKQQGKEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRC1</accession>
    <name>A0A8H5GRC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipase D1</fullName>
            <ecNumber evidence="4">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_002583</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="19">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="19">
        <location>
            <begin position="1057"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="20">
        <location>
            <begin position="3512"/>
            <end position="3643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="529"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1202"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1428"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1543"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1217"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1552"/>
            <end position="1564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5369587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="3744" mass="427665" checksum="CFC2D5B07005F36D" modified="2022-01-19" version="1">MVKAQMAPAIADIVSQATAGSKPSANAEQADQQASPSSYRSIRIPKVDPRQYRSQPSTPSMRTGPPRSLSYVYSLPNSPSNSRTNSRYENENEEIPADGDENDGFPFSAPSEFRGVLEVGSSMSSADRREKGKKRESRFLDESWNPMKWFHESPKEEKSGFEFGEKGKEADGDAGEEDSKIKGPSLRRTKSDPHQSSSADRSSRAKWGRLRSLLPQMVPQGQSPSSPHDANAVTSYAVNITDELITGGLSTLMLRLWFERDEKGHRRVPVLLHRLRVRISDSLHPLHGHKSVFRIECEYANGAVRWVIYRQLRDFLSLHAHYAVSNAYNRNVDNLPEFPRTSLPYFKFLLKERGREVEQAEFARLQRQTLENYLLDLIRAVMFHPASNRLCGFLEISALSISHAKTGGTQYKAGFLQIEAADSKGGGFGRKGTSWKAKREYRWCAVRESYLVVMEEPGELTVWDVFLLDSDFSIERPKRYYRQGLNLLHSDAHDEEAPNQLQRVRSNPEKSSVVGTIKGGFSRIFGHGRAKTAEEPHADDPENDSDSSSDSSVSFHQTTPMLDPSTNVNPFSPSGGAEPDDDEDHPWTGTGKEGKKKKKADPNEVSKHTFFISNSQMRLKLYAKNQRQMLQWITALERTAATSHYTGRNRFDSFAPIRLNVAAQWLVDGRDYFWNLSRAILLARETIYIHDWWLSPELQMRRPDKGRYRLDRLLESKAKEGVKIFIIVYQEVSSRTTPTDSNYTKQRMTSLHPNIMVQRSPSHFQTGTFYWAHHEKLCVIDQAIAFMGGLDLCFGRWDTPQHVIIDDVDPDSGQSQIWPGKDYSNPRVSDFSNLAKPDEDMYDRTKVARMPWHDVAMQVVGQPARDLARHFIQRWNYLLRIKNHKRVMPFLLPPPEFKPGELTQMALTGTCEMQICRSAGPWSLGTPSRIEHSIQNAYLKAIQMSEHFVYIENQFFISSTTVNDVKIENKIGDAIVHRILRAHRDGTTWKCCIIIPILPGFSFPVDHSDASANRTFARGPNSIFARLRKEGIDPNDYITVFCLRNWGKLRGDILTTEQVYIHGKVCIVDDRLAIIGSANINERSQRGDRDSEIAAIIRDTDMIDGTMAGKPFKVGRFAHTLRIRLMREHLGVDVDAMYEEDLMAKEPLAPEHEQEMWDPDIEQQYGVEGVTKFDKSHQKGPSGRLFQTVGDGVAQAISAATEASSTSTRKTLGKVGLMKERTQDKVGNETLDEERKTFTRDGKEEPGFTSSMVPTAEEQLITENGYPDEKAGKSPGLVNGDAKAGETKENGIGVPDQSRVEGGELYGAPAGASTSQKTDDQPPHSQPGGVDDADEEERAAPGARSVLRKHLGSKLGNKTWTLPTPRPKVDPNGFDDPVSDAFWKQVWVASAVHNTEIYRKVFHAVPDDLVTTWKQYKEFVLHHERLNKPPRDSAVPEAVARIPSETGDESVPLEGKEAQVDEQQTGSKDGQEDGDVHLGNSASEKDPKTRKAAKGIEPFEKWERDEMEKLLGELNGHLDFVNAKPTTSSSTNTRMSIPAPPPGFVPPPPGMGSPSNGPSGSKMPPEVLAQKSMKWVQMQRKRYGEKRRGGYVDMGKQDLPPEHVRKIIKDHGDMSNRKFRNDKRVHLGALKYVPHAVMKLLENIPYPWEQVREVPVLYHITGAITFVNEIPRVIEPVYHAQWSTMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNVLDVEPLESIQLELDTEEDAAIIDWFYDPKPLIDTPSVNGPSYRYWSLSLPVMANLYRLGRTLLSDQADRNGSYLFDKNAEHGYPGGPKFEPLYRDMDTFDEDWNEFNDINKIIIRQQIRTEYKVAFPHLYNSLPRSVQISPYHFPKNVYIRTDDPDLPAFYFDPLINPISLRGMTPKNMPLVSHEDSIFGPNGADDDDFELPEDINPFLEDKDLENDLTADGIALWWAPEPYSRRSGRMRRAQDIPLVKNWYLEHCPPNQAVKVRVSYQKLLKCYVLNELKTRPEKAMTKKNLFRQLKATKFFQTTKLDWVEAGLQNLNYLHLDYNMNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQFRLGNVDAFQLADALQYIFSHIGALTGMYRYKYKLMRQVRMTKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGIVPLLERWLGNLLARQFEGRNSKGIAKTVTKQRVESHYDLELRAAVMHDILDMMPESIKQNKAKTILQHLSEAWRCWKANIPWKVPGMPTAIENIILRYIKNKADWWCSVAHYNRERIRRGATVDKAVVKKNLGRLTRLYLKAEQERQHAYLKDGPYISAEEAVAIYTATVHWLESRKFAPIPFPPLSYKHDTKLLVLALEKLKEAYSVKGRLNQSQREELALIEQAYDNPHECLSRIKRLLLTQRAFKESGIEFFDTYDKLIPCYDIEPIEKITDAWCQGINNLTDIWETSEGECNVMMETVLSKVYEKVDLTLLNRLLRLILDHNLADYITAKNNTVLTYKDMAHTNAFGLIRGLQFSAFVFQYYGLVLDLLILGLQRASEMAGPPQMPNNFLQYRDSASETRHPIRLYSRYVDRLHILFRFTADEARDLIQRYLSANPDPTNNNVIGYNNKRCWPRDCRMRLIKHDVNLGRAVFWNVKQSLPRSLTTIEWEDTFSVFCPRYGRRAGSSSQLKDAVWNLTNEQTKERTAQAFLRVLMSSGSTTFSKIVNKWNTALIGLMTYYREAVIHTNELLDALVKAENKIQTRVKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVAVTHFRAGMSHEEDQLIPNLYRYLQPWEAEFLDSARVWSEYSMKRKEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDRGWRVRTDWKQYQLLKHNPFWWTSQRHDGKLWQLNNYRVDVIAALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMRYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEPLQIETVQKETIHPRKSYKMNSSCADILLFSAYKVSDSMSIYPSPTGVMIGMDLAYNLWSAYGNWFPGLKPLIQQAMAKIMKANPACHVLRERIRKGLQLYSSEPTEPYLNSQNYSELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRSGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACMKMEKFGDLILRATQPQMVLFSLYDDWLKSISSYTAFSRVILLLRGLHVNNERAKIILRPDKNTVTEPHFVWPTLSDEDWIKVEVAMKDLILADFGKRNSVNIASLTVSEIRDIILGQEIAAPSVQRQQMAELEKSSEAQSQVTAVQTQTTNVHGDTIQTVTTTNYEQQVFSSKSDWRVRAISATHLPLRLQHIYVSNDDVKDDAASYTYVLPKNILRAFITAADLRTQVAAYLYGVSPPDNKQVKEIKAVAWVPQRGSNNSVELPAQLPKDDFLLKDLEPLGWIKTQALEIPHLSPTDVTSQAKIMADHPEWGPSSICITASFTPGSVSLSAHSLTVAGFDWGRKNVDTSANPPGFNPNMSERVQLLLSDRILGMTLVPEGRVWNYGIGLTQLWSPNLNYAMNLDTPLLFWAEEHRPAAFLSFANLEQGEDSADVENSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS02</accession>
    <name>A0A8H5GS02_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS02"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="200"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="556"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="680" mass="80199" checksum="45D5AFBE4F045B5A" modified="2022-01-19" version="1">MGRYSSRSASPGPSYEDRRYDRERSGRDRKSNTNHYEEERRKRKRSHSRDRDDYSKHRDKDRGRERNRDRDRDRDSKDRSTSRDADKKKKRKREKSEERKARKAEKKRIKEEEEARQIAELSVYSATDNPFHDVNLGQQFRWHKKNEKERKQGLTLAESQRRDAIRREEAKMELERLNRRRAEREAEQRLREEEELRMQRMQESAQMSEWLDKEGDFQLDQERSRAAIRIKEKRAKAIDFLALNLKYVNPPEEEDEENEDDDAGLEIDLDEPYNILDNLSNEQIEELHEDIERYLTLEQSETSIDFWTNMMVVCKDRLDRIKSSERIGIEAVAAVEADISRLLSGKSYNELAALQRQIQDKLTSGEPVDTDYWESLLKKLLVWKAKANLKSLHEVVVRNRLEQLRKRQRDEALQAQEELLAGVAKSASSGAKVIAGTATALSEPVNAELVEEYDRAMSPPLIDITKLPAEDRNIDIVTAKEDLLNLLDQRRTVAGSRFVPKAAQPVTETEGEEIDASGTDLASEALYRAEAERELDEEEELFNLEENIANPTSYNWEDKYRPRKPRYFNRVHTGYEWNKYNQTHYDTDNPPPKVVQGYKFNIFYPDLIDKSKAPTYKIIKEPGNDDTVLLHFSAGPPYEDIAFRIVNREWEFSHKRGFRSSFDRGCLSLWFNFRRNFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSA8</accession>
    <name>A0A8H5GSA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSA8"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="28039" checksum="38B1D31236A3E4D2" modified="2022-01-19" version="1">MTPVFLLPLGLRITLQSFERFVNLQEIDNPKLVLIIGCVGLRLNATSQLMPIPATVTLTGTTTTTTTTTIKSQTCTLIMTMVPIYIPYASANAAVHPDHYHRLEPPAIHPPVGANLGLVGVLIHLLGDAVNNRSTCLVGNEFDHFCECYSIDQKMRAHSPRSCPRASRPRGYGMTFFYSRMWMLYPSTSDTSPDPTSWLPSTSASQPAKTSMCEWSPIENLIQQCYEAYGVNLKHVTISPELRQLPSRTGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT66</accession>
    <name>A0A8H5GT66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2742726at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2264" mass="253761" checksum="128A3EE945CAAE75" modified="2022-01-19" version="1">MTELRPSSYQPPPIQAPTITLPRTDSPQPSEPNVPVSSLSVAVGVELIVFGLRHDTPSAAKDDLTTRLAPYSTDNRIPPITIRQADQRQALDYAYVSLAPPLVDPPRPDILQELKTFLAEQFAELDVQWRVNSKLDKTRQVFFYISEDTGLDVKKAKDGLDDIFKSKGYKVQNSYSSSNTKRVTYTFFSSTTLQLLASDPPVVQGHRLLPQRPRFIQPICGLEIAVPGCSEFQNVRSRLDHYLNTRYTDKYDGDVVVGSRMELDGDVYCAVLKNWQVVNDVLYNDEWQPFSGSSAPLAQLSPSCRPILLYVLNSFGIPSNITELINRVSGASSQENKELKAEVEQLREDLKVATRMYVKILESQQSLIEHVNERFQQVTQTITHAMLYATTHATYLAANTRLESLEGQRVSYLQHAAIATNEQQKLLFETHASMLDPRIESAKRQLEQAQQQMDTFAHSLASVLPGIPVPALSSPPSQPSLASSSHLPPASAPPSQSNTSDDAQLQQQLPPHSSPASIPPHLLRPDVDDDMHDADHGVNNTHNASDGGDDASMYADSDHDAPGPSPPASQPSQTNTRKRRRPDRPRNPQHQSQSQPQVPLCLPLSSMSLTSSFTVTAPVDDDVEFIYVDDSGRTEVSCMDSNTVVPVPVVNSVPMLLKMVAVTILVVCLSASVSALSPPLRTFALNANGLGDNSQLNLIQNSLHTLNPHLIVIGETKNSRPVASRLRLHQYSTYENPGVPTSSKKSSKWGVILAVRKDIHSDQVMVPAQLRGRVSAADLHIPDSNGTTIRHRVIGIYAPWDPGVDALRDFWSSLTELCNNSPAQSWSIYDDFNATLATCEHSSSQPHLPDARQAYSQFLLSTAGQDLWSDIPDRTVQTHYTYKGARGMSIIDRVAVSSSAIVDAKLQVLHNFFGSTDHCALLCNVFLRGSATLTSEYTDSVRLPARYRVPRRDQRFRFRIFTDNVSRAVSASPSLSRPITTDDDFEKIYSKFGRILHSSAAIAFEKPSQFFSSPSSKSISSPTIRSIQREYKRVNRLVSILKRAPSSLPTFALANLWAQQYLNAFDPSVLVSPTITLSFTFLSKFHEYLKRLRSSLSKLRYREVDAELRRRATAASSARINSVLLGGSAKRLFPSQFCGPPRVVCTSLPNEPEIFVSSPEEVKLAMVQYFQNLYARQPRPPHPKPWMQTPSILAIRQKTSADPFTWPKLMSLLDIRLILRKGNPKPAPGPDGIEKWWLKHLDDDSLSIFQHLVNYILHNSHAPSCTKPSTLSIFHKRGSRTLLRNCRGVTFSNYILNHIGAWENFHLVPYCAKHNIIPPTQIASQPGVQGRDLLSFLAHLQTWAVRNKQSLYVLQRDQQKGFDMLEPEGFYDALRAYGLPQSLIDLDISFQSNVPYSILSAYGLTDPFIVNGVTKQGGPLSPLKSCLMTSLGHYWLNDLLRDDPGALVISTANCRNHCFHTPIDDVTFPVHMVEAMDDSLLLATRLSTTRHACLAMERLQSCYGAKTCWPKSCMYFLNVIGPIPQTITMPTVSPENPFDECLVPLATVPVSSDCIHFLRTDVDRPKAQYFFLRDLIIDFQLPLLSKRLPLTAIRRILSQCLISKIRPRLSYQPISHADAVHLDVLIASKVHHYFGYPFHPSSTLLSLPVSHFGFDFPSIAELNLDSAVRGLLRDLNHHVPVFRQMARITLADWSCSLNRCLHPFVYDSLHRSFLPFTFSSHRKLPFAWVLAHDHLQKLDISLHSMDQSHVFLGDVSLQHCVNVLRHSRSFSSVHALPNFRQISELRNFNLDKLSDFSSWTSFPSPHLQLSLPSSRRFPSDFLFMTWYPLLLVLHNLSLLSLVHADASLIPPSPNVLQHRSITFAALHDSHSYVASVQTSRLFSNILHGELYALILATLLYKKHPTSPNLTLLSDHLNAVRFLSNALSHSPSATVWAALPASSLYRWLYSLLISLPNSPTISHVRAHTSQLDIPSQANALVDRHASLAQQLSTPPPYAPLPTFAMADYVLYHSSFGYIESGIPEVLKSLYRQVVVDPLSFSPAARMMRSLYDPHPPPSHPYLRASSAYSASIQLYLRSGQLPTRQITAPRLHEKSSLCRFGCCTVESPHHLFVQCTHFNRIRAHYTARALESLQTHAQSMGIPRHWHENLHRVANVLFYDHSLWPLSSSRYYFGLLPEIQPHIPLVPSWSTLARERFITRLSNSWHYLAIQLAARIWGYVQRLRAYEVSSSSPRSARVKCLRKSLPSHLHHLISTFSDTDPPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTC8</accession>
    <name>A0A8H5GTC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTC8"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034369468" description="Expansin-like EG45 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="2">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="26020" checksum="873B05054952AB54" modified="2022-01-19" version="1">MTFIVLAFLFALVNASSWIQYPPNGFATMTHYDLPSGYIASCACTGKSTNYPTSAMNQMAFGSAVAYGSACGKCFNLTLLNTFLSDPPFYPPTSKSIVVKVTDLCPLSTTGWCNATQEGPNQAGNYLNFDLAYPSSAIPDDFFPSNASLYGYTDFGVWNISYQSVDCSNWAGWKDEGALGSVTNLGPESACCPDNPSGNVNDTCPSYSDHNGIAPDTRTSGSPSTISSSGLFVLSVSLLTVYTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVU7</accession>
    <name>A0A8H5GVU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3056903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1247"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1692"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1700"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1733"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1754"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1766"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1781"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1804" mass="203850" checksum="96D0E67B32B3A58F" modified="2022-01-19" version="1">MRKWLGKSIIHPAVDAIFPESDSESDDSFDFTFSNTEDTLVLHQDEISRPPEEYLGNPDSGEEKDNGNASDMDIDNGELGCPEVRTMPPVNESCEDKSGLQHLPTRRDETQLQTLKLFNFKSIAKAMQPSTIPTDPQSNVIPSKSAVVPSVQSTSHSVGNLQKPLCPPTTVASQTVPPSSSHPPAVVRTAPLPPPATNQAACPVDLTDPARLTAFVPLDPQPEPQCRHGHDVNVQFTTVDNLEQGFWNGWPNGKFAIDLDHATYMKHGMLAVQWATRNCKGNNGKKNQKGSIHATTIAGGKESYKKCLGVLRCTNPQCQVITRPKIEKKILEAQCLNEYCICGFSLEHFDCGAMSFLIEYAQVGDDITTRLYRYIHAGCHNHPRIPYTKHLTAQEAKDTRQHLGNNMHKKHLESYEGGETLDGPTPPAPQLAQKFANIETYRYETKKMTKGATAEVGWSFINQFHSWIQQHEDEVQIRINTVGREPECVISFHSKWMQDQLLPKAEFVEGPLPLEGMLTDGAHKYWADPNAVLISTTTFNTVIDRWVPSMFSYANGVTTQHYHWHFTAVIEAIAEAAHEHNEKITDELFALVVDFSDAQRLGFISAFTDYFIRQEDNTRTRTELENAAQSLIKGCRYHFEKSVTRVARLSNHVPPDSRAEFEELCRQMVIAENSAVFDRVVKIMKETWPGLEAWLNWWLAPEHASMIFHSQRKMDSKLASKLPDTTNAEESVHSVIYQIAGKNKDIIQGFDGLLKVMRHFQRMHDSYIHGLPIRYGRSQRQRKLDQLERCEAETLTEIPRRRRQSYSHKPSPRKRDRSALREGRAPDTQSTLKRPRKQVKITVPNSSESEDGSPSPPDIVDKQLTQGRYKELSPGKTRPTDSFTSIIVNLAAAKEFASYPWANNSCWLDASLEIIYVTLACHGHWKDFSSFAADITYPISHLHKTLSNRRAWPLSTFPGSKAGKSVILQNIRDTFKHVLAGLPFCLSIAENSYAMYKGSQAAVKAITKLRVLGPHLPPGKSQQQDISNCLGGRLRTGSSQFSTYPQWRFHRKSRVAGDATQRRAPMIQTSIAMGSARKWSLLAGYHLYSSSDQVWMKKAINQIGISLVNYTQAQKPQVQEMEWYTNLWHACSQTKHTFGGQSAVFSYDGMENMGYSQLVKGKIGDLLAGTTGYQPDGYQTVCAVYSLKGGIVAQEKFHEDCVKIALQKLDLQLDGTRSTTLTKPGYREMTREETVNWKPHISITEYQQTHSDSRQVVKPEPAHSYSPSPGPSPTTPLRTIPSSSPPPSTPLPILCRCGVENDGHRELIKQVTVQCDKCHRWSHLACLVNRMEPTIKGEFLCHVCDPASMLDTSSSQIIESLKQGVQLRANVAKRLYAGRTVLVQMDANTLFYYPGRLLHQEKGKWTIKMWRGIKHENANKVLENISVKRLVDGLYGDREGRRSIRLGRFIRTHEERDPADIASDWQVYQYNTEVDRALYKHKAMLQKILHHTINSEFSALSVSSVPALALYLNEGNPGYAIFRNHQYMTAVTLFRRPCSAYFTGGITTDDQARILNWLHINVQSFLSAPPKDFELCIAHARTLFLAHCHRETFLGCIEAGLSELEREQSVLHQAWQRLVDFSGKTVDGKMKRLKADVDREALQILEKVMFDRSQKAGVAGSEQWGLDVGPPEDLWWPYDGPEKNDPDLRVATESDLEESEFCKAEREKMEQKVREKEAEKQNHAPPRPKPRPLTKEQAAERSKKALQEAGLTAERPDLAKEKVVKTLQTVQENAQLRRSKRVADQTKETEETENNKKSKKQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW36</accession>
    <name>A0A8H5GW36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW36"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="740" mass="82281" checksum="0224E22C6D0CACBC" modified="2022-01-19" version="1">MNKRGPKPGTPRTTASQPVRVLVANILKGTRSEPFLIPDDKEDIRKMLVKLANWIEELEKDRELRLVNGDDDWIFNNPREKQNLKSTLPSPNSANAYPPSSQPSRSVEPVIPDSTISMEDTGKDIDVAATENIEDLSKELSDLSFGASKTHFGESSTIMLWPSWYPITRPQSETTTPIYEFPPPDAFGQFVNAYFREWEPYKPLLHRPSFNKTVADGLHLRDPAFGALVLVVCGFGARLLSGSHQQENLGEYWVRQIQLDAFVFSPMLELYHLQLYCVCTLLPLRLVDCDFLPNTLTSSIEQLMISYLYTVTKGVDSAWLLAGIAIRRAQEKGAHRRYTNDSPTIEGELWKRAFWALTTIDISMSTLFGRPRATSIQDFDIDPLVECDDEYWDPEDGSPGFVQPEGKPAAVSYWNSYLKLMEIYGFTFLTIFNGKNSLKTQSFSVNPPYFTPCITGFKLRSIDALFLVLGIELAYYPSPLWRFAQTQPERLYVSARRRLVDILNSMIASHLPTQPGIANTPGSPVASASLPSQVLQSQNTPQPSHFLPGWWPGSDAAKSTLAPSAAFSTTPDGANTPSPVHLPFYSNELGELPVHKNFFNDSVSNGEQVYQTPSPNPSFGYYFHSSATPGAVAFDVMASASPASHPDAAYMQRCFTLFDDDMGTANTASIVQNGNPSASQDWDSFMAGVNKLLNSTSIPLPDTTFADTHLPSNCLFWSFTSQTPPNTFIKGDDPDVQSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX51</accession>
    <name>A0A8H5GX51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX51"/>
    <dbReference type="OrthoDB" id="3352285at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="37911" checksum="C447A4654ADD2E47" modified="2022-01-19" version="1">MNSRTPPQGAPPRYALVNRVYSRNLRPVVIVFAFLSFLWTLFAYAQSPFLTNSLSNLSLGLWIGSFRSIGIERHEGFSKLGTISIVLGVLYMTVSLFEAFGVFAAWSQRTPLVRIYALLSAATTLIVIGGGIFEIVVHFTMKGDIIGVCTSSLEGEDFVEYPFGFFGPRRFGTINGQDASDWCNREWDHDSWADIVGLLILIFLSALFTTTAFAYYRQLLDPTSVANVTRTPQNRMGPGYPSHYNPPYEGSVPPLGYNQPPYGGYAPPPGPPPQATFARDVEGADGKPPGYAGGDGSLSYGLDDKENPFADFDEPVKPNGSRRNGDYAEERDVTSRPAPGGREGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYQ1</accession>
    <name>A0A8H5GYQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYQ1"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="3">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="635" mass="71595" checksum="F75F488FD0C2D279" modified="2022-01-19" version="1">MVFTADKEVVEHSVLIKNMLEGLGILPLPAPNTDSSQDDTRKRTTNISKWDQKFITVDQEMLFEIIFAANYLDIKSLLDVGCKTVPNMIKGKTLEEIRKLFNIVHDFTPEEEAQIKKENVSSLFSINSGGDYTPNESLDDSHLTGGLPEMQGFNPNDFETSDREARSRCFQPPPAGSVFDGDWTMREEIIEIVDKAISAGAIFETDLLACRLGYDKDMPLDKFEQYVFVMVPVKKHRQGAALKAVMKMAHDLEAVIKEYVNDVSVIVVESMFEERVLTNPLTLMKSLAPTNTSVDVLRDFDWTLSSAVGKLDRPGISTYWYKGTELFAKGCRHVYANKVPGKNKAFEFQQGRSLVLEVIQPPNATYNWCVEELKTSHAVFTEELKRHKKAKKAMEEARVDDDEYQEARENENRARRWLERVETNQKHLEQRKTLKSRVIGRLDWSHLVLLYTKSFPEDPRNIINVGTVAHKVMVEKYMNPVESQANYFRVPNNLNIPINAHALTEAEILKPTYINAEGEHAHLMLHYGRQLSGEGKGPRVGWLSTSKAQRFWKLAGDNMKTSDLAVYSVIKGRPFSAPGHSGAIVIDRSGNQVMDIMTGEGLILSMDVTYGCASHVANAEMAARDYSFLTGSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZR9</accession>
    <name>A0A8H5GZR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZR9"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="58"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="38954" checksum="EA16FAC28A8FE627" modified="2022-01-19" version="1">MTSPSERAYKKRNYKAQNHYQISATSNYNTKPIKFHCESNTAMSNDQQQALLILSKQGAFAVTTIPKPLPIPKGELLVKVHAAALDHIDWKIQAYGLLYPEDKYPVIPGLDIAGEVEEVGEGVIHFQKGDRVFFSGDFRNEYSGYQQYTRVPADIVAKIPEKLSYSQAASIPVGIATAAIGLHACRHESSVKDIKGKTALVIGASGSVGQFGATDCIDRAKVPFSTLTRSIINSTSTSSTPVEVVYDAFGSAESQLAGYDTLVKGGALISTGPNQFKDRSEGDGKTFIGVYGNTHVEKNRAFSSQLFENLPLMIERGIIVPNEVEDLEGGLNGIADGLKRLRDGEISGVKLVANPQETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZY8</accession>
    <name>A0A8H5GZY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Natural resistance-associated macrophage protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZY8"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65035" checksum="4F83A9437147970E" modified="2022-01-19" version="1">MPNERLSSTDLQDSNCTVTYTHDTDNDDAKASPPPKSRNSWRWQVEKGILLFFHHMRKHVGVGLICAVAYFDPGNWGVDLEAGSQYGYRLLFVILLAGLFAIFLQVLASRLGCVTGLDLASHTRLLLHDHSTHPLLVRWAVLYPLYALAEIAIIATDLAELLGSAVALCLLFPSLELWHGVLITTGDVILLLCLGDPLRGKPLRWFELLIGGLVFAVMICLCTIISRVELDWADVFLGYLPSKYVFPNGAGYVSVGIIGATIMPHSLFLGSALATQDRVSPSSPEPDDTPRPLQLERSFSVASSLLETKRHLKNFFARTFNSAILVPEKGTTPMEILKDTAKNHSQWINNSQEFVKKHIYHGTVDIVVSLLGFAVVINSLILILASAVFFYGGVDVDNAGLFDAYDLIRDLVGKGAATIFALALLCAGQSSSIIATVAGQAVAEGFLRWRVSPFIRRLLTRLIAVIPSMAVAIALGRPGIDALLIASQVVLSIVLPFVSFPLIYLTSKRSVMSVRVAGAVIGPSVIRDNRQVESTFSTTTKDNDLTLGQDAESQANAPDADKIVDYSNNWFATILAFSIWLVIVIANVYVLVTLGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0B8</accession>
    <name>A0A8H5H0B8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0B8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034365193" evidence="2">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="241" mass="26382" checksum="F5346A5F7ACE0859" modified="2022-01-19" version="1">MTPYLLTLPAFVSAFTLTVPPDVTVGVASQATFITQNTGEDPYGFDLRRKQTNGTFEVDPSNSMLPYNFITGVVQFTVNQPGIYRVFVWDAVAGGSGPLNPITNIPVVIGVVWLVLIGLRIRWLWRRRKHKKRGQGGLEPLPFVQTTSPSNFGPTINGYDEENQGNRNVNTMAIPDPTLSSVTPNHGPTQTADSSLQLFTRASHLALNEVSIGITGRDSHTYNTSNDTHYHYHGMGPGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0D4</accession>
    <name>A0A8H5H0D4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0D4"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF29">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="923" mass="103185" checksum="C2E66C49A0087139" modified="2022-01-19" version="1">MNCKNPLMSKDWRPQWAKDGVVPAYMTDNSSYRGWDGGGNFGFTGRHLWPWGTMPALDVLNLESNEKREGVITRDFSLAFVASGDLRNVVKTVNELPDDYQGSLNILLNDRDPLIVSRNLVILALLGLVAEDLDDATEYALHVWYSIFLSSETYIHKQLKLFQQLDISASTKPGTQRTLSFGPHSSLRVLLDNETLSTMLAVRALNGISRLSPATASQAFHDLMMAPQRLDYRHRYYYGLDPSHRVAFEKWRQEGIVYPFGTCSAHLNIPNPWLFDPESHLLRYRIEVGKLHEKTYSDYLKDQLHTFAHRLRTFKINISLTRCPDAIDFAARVKKGSIPGIPRSISFDRIDVSSLVDADAKDRNTNKCTGPGLVGLGIKPVLESWGPLLKSKQENEYAALIGFFTMLWASLTDAPEATNEMMRRFAEYYPNPLYHLAMSESSNSTYKIEPLKGGDNYRTWKVKMIDILTDLDLLEYVDGSRAEPADQSAKEDWKKKDRKALSTIRLRVDDSCLIYVEDSKTSKEAWDALNDMYEAKGPIAIVLLRRKMFTVRCEEGGDIETHIKLMRSYQSQMNTLGQKIEKADFSMLLLTSLPDSWDSFISTFGSTDLEDSNKVIQRILQEASRRNERSANSDAVLTSSSKPSGKSKFNPRITCYCCGRLGHIAAECRCPKCRNKSGNSQTSNQSRNNRSSHAHVAEAPDSDSDKEGPTYVFAAVDAAIPTVSHTSGLSSDAWLLDTGCTRHVVRNKEYFVDYVETPGHQLIGLGISSGLGTGTVNLTLTEGKETTRIALSNAIHCPTAPYNLISVGKILSAGITPVFQGKNQLNLVNSHGTIIGHAVKTAGLFPIDASVAEPTRAHPAIAEIDAKTWEEWHRFYGHLNIGSLKLLKDKAPQNSNAFHVFNQKATRRRSLKKQSATSLNPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1A6</accession>
    <name>A0A8H5H1A6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1A6"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF12">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="37535" checksum="810EF8C13185089F" modified="2022-01-19" version="1">MPRPLRVAAAQVGRVDRSEPRASVLARLITLLEEADKQAVKLVVFPETTFTTFFPRYLITDDVELNSFFENEDAVTGIVDAPNVKPFFDKAAQLGIDVVVGYAEKTPDGVPYNTASYVSGRRVVSKYRKVHLPGAFEPFNDHPDTTNQLEKRYFKPGDLGFQAFRAPSLRHEVKSPIIGMLICNDRRWAEGWRCYGLQGAEIMCIGYNTVAWAPELWGADPNMDRDFARQDALFHHKLVCQAHAYTNAMFCITAARCGWDDGKFELITGSMVVDPEGHIIAENKTDGDELVVADIDLDACLQGKARTFAFEKHRRPEHYGVIVERAGVVEPPEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H239</accession>
    <name>A0A8H5H239_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H239"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5375266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="581" mass="63516" checksum="A61AAEA1B262D82E" modified="2022-01-19" version="1">MAISIGLGIFFGLLASFVQSLGLTIQRKSHVLNQGLPEDQQRLEHKRPLWLLGFAIFISSNVIGSLVQIASLPVVILAPLGAVSLLWNAFFARILLGDVFSAWMILGTLFIAGGAVLIAYFGIVSEPTRSVEDLLALFSRTTFVVYFSLLGAAVLVCLAITHLSEYRLSKRLVVVDPSPSPTGTEGERMPLATGITDAAEMVATERTPLLDSKYNNASRTPSISSTSNLTSDPYTRSINRTRVLLAISYASFSGIISGMCLLFAKSGVELLLLTIQGDNQFWRWQSWILLLALVIFALLQLWYLHKGLVLADPTLVCPSAFCFYNLSSIVNGLVYFDEFSLITPLHLALVCLGIVILLAGVWIVSIHAGGGGVDFAAWDSEEAVDAESCIATTPPTSTRGPTSDDEETNYDWGTRSEPLMGASSTTSSPLTERSTMSPDSAQRSWLRQSNRNTNLLDTQIPRHRRTSTFSHYNPHNSYTPHSPPLPTVSTLAGTGFQIGLSPVSPGFNILPMERRRRTSNQGSSLMDGERRRAVSEGNIRRLDVEEDHAGTEQVNGRDSTDIGVENPQAAKRGWRRWLRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHL3</accession>
    <name>A0A8H5LHL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHL3"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="210"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="833" mass="89690" checksum="E60E0CE6B326AFE2" modified="2022-01-19" version="1">MSFVFHGSTPSSQINLTPDEDVHPSSSPALPPHEHDMGREKERPRLEVLLDKETICLKGTGVDVEPARLSGHVALYLAESTSIREITLQFRGKARLLTPNHESLTLNSNPVTYIICNHEWSFLEGEKRHSHTLKAGRHFFPFQLQLGGSLPSSISTTSFGGASVVYKLRAHAIRPGFNHNLQALAPVSIVRSFAPEALEYQQTLEIENTWPEKLMYSIMVPHKAWAAGDTITALVKFSPLLKGVGVLNITTTINETVKLYTRTGHQEHSRAVATARHEIVGGKAVPVPEHEHRSRVNTPGIHSPGHSLPNTPNISSGARSSTGTGSSGGGGGGGGGYFSFNPHPVASALSTLHEAGPSTSTSQSQNDDSDENLEMSPNDVVTHLTIPAPLTITPTHGLDPIIVSHRIRWSILILNPDGHTSELRCSLPLHLLDYRLLDEARMHTAATRRLLIGGPEVPPQEVEDDMELPSYNAHVRDRVANMFLPESATMRVANPWVRDGLSPIPGNNASEVHSPWPLSRSGTSSPLEAHLLSHLPHAPGSGDSTPLDWVNSELLLSVSQGAAPPLNPDSRPLQLRTPPSDHSDPSSTANSNPTSRPASRFASRRSSRASSPERGSPVVQPYHLHVAGPHETYIHSPNASRNLHGLFKVSMKPLTSLTHSSWLPHTRSSHSHSSSSLASMVSHPPNSYFSGSHNFNSHVPSSAPTTPGVRPIHLTDYNAGNSHLHRPFTEVPDYRMASQGFIGGVPPLSSMRGLPSYEEAEQGNSQRTRSDTDLTERFSSLLSMSMPMPNGVAAGAVGPAPGPESGTDSLVTPTTANISMSMPATPVGSPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIN3</accession>
    <name>A0A8H5LIN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIN3"/>
    <dbReference type="OrthoDB" id="2790258at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="773"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5358776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="920" mass="102704" checksum="314B526EA506B48D" modified="2022-01-19" version="1">MGSSQTFLFFTKQHLAYGTLVTSEIGRLGSLGPASHVVPLAAVTQNSLNFIAYNPQRASNTRKRVSNSDQDTRNVRSRTSSDKENITATASTINPTQTASIAGAGPIPSNSSPAGDACVPPALLAGIFRSFEEKRQNSESKKLATDIWHFILPSPIARIPHFGDDEKHRTEKPPVEEAEFLACRLCEQGATRPKAGIWKNATGGLTKNIRNHLTTKHSEKFEDAVKTLGLKGADLMNATDRPSARRKPGEPFNSERFLSLLIRWIVVDDQSINVVECQEFRDVLEYIGVDLKDGAIPHRTHLLELIFGQFETCFKNTREEMNRSLGRISFTSDMWSRGNLQGYMAITAHYIIREHGHLILKSCLIAFRHVQGSHDGESMATHFLGVLDEYGIANRTGLARLNVFELDDDDGVTSDEIYEQNPPAPKIRIPAEYLAALEKDVISCVRKLVNACRASGKRRDGLRQILIDKLREAEAAFQAANPHLQGTGASSDTRVVVLLRDVDTRWSSIYLMVDRLLELYPSVKKFALQPGNEEIKDLLLSDWELSVLNDIRIVLHSFHMIQQLVSAEKTPTLAIVLPLYEQLTSNLKKIQTKLPYLSHMIESSLQKIYEYVGKSRATHEYAFAMAINPTCKLTWIESQWSAEDSGKAKSALIEVLREHQTALRHDAEKAALGASTSRPASDTRNHHNGSNAAYAQSVGLANLDAFTKSLDSLTHTHSLSSLSTDADTSTNSENELDSLESELDVDVSPHDTLSDEERENQAILGDEVIVKEELQNWIAAGIVPRSEVKDLIKYWDNDQLQTKFPTLFRLALDVLPVQASAVPCERAFSSSKQTDTDHRSRLSPIMMEVLQILKAIYHDDRLDFTKSWVAKSSEMEETEEEVTVNLEEAIGVSMDEPFREMLLQGQFADLARLIHHSDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLP5</accession>
    <name>A0A8H5LLP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLP5"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5361718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="34722" checksum="3361E722FB5563C4" modified="2022-01-19" version="1">MVSPLSSLMYTPALPAIADALGVSISDVNLTVTTYLIFQGITPSIWGSLSDFYGHRVIYLVTLLITVGSSIGLCLTDSFAVVLALRALHATGCSSTRALGAGVIRDIAPINVRGGYIGLYSAGVSVGTAFGPVFGGLLAQYASWHGIFYFLLAISVSSFLIVFLVLPETLHFVRSGRGWKPPRYVQPPFGLSWLADDGDGCELREGSQSQQLPAHAPKLDFFGPLRIMKYPDVLCALIFTGIAYTVWQDNMVATSTIYSSRYGLSEAKIGLTYLANGMGALIGDIAIGRILDHDYKRQARKGDLVIEHARLRSLSYNYQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LN00</accession>
    <name>A0A8H5LN00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LN00"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="88595" checksum="2339B54D9CE8CC50" modified="2022-01-19" version="1">MRLLNTSTYELEEFFGSNIPEYAILSHTWEEEEILFSDLRDESSRQNAKLKKGWDKVLGACERALYDGLEWVWIDTCCIDKQSSAELSEAINSMFSYYRDSFVCYAYLSDYHISITGFPDVHNAGRISLGDCRWFTRGWTLQELLAPFDLVFFDAEWEDMGTKYSLREAVSTITRIPPHVFVDKDITSFSIAARMSWAADRQTTREEDRAYSLMGIFGVNMPPLYGEGGAKAFLRLQEEILKYSDDHSLFAWHAAFDPQNPYFESRGLLAESPSEFRDSGDVCTSTKTGLLKSPYSMTNSGLRIHLPLRRAPSFPEKPSFLFTAQLCCQLGNNADSPVFLSVYLEKVEGEGYTSWHRWRPHCLLKDRVPFHDDDVREIYVKAIQTSHEHRLRPSKTLYSKSRKPHIALSLKMPSLQIRPNSREPYYDSKTGRWFIHYSLYDTNSPRSTHELRCALPGAADPMLLYIRDEVFWKVLANIQEPNNELAERERLQPYFRDQMPLSFHERDEKAMISLRKLLVQTSLAGALLPAVEVGCRLEIRSIQRVQEASTGGQSHRSLQQSVSRNDPKILVIPFRLRCSELYGVTVLTTQWDFASSPNWPALSWTTECDWHSDPARRYYNGVSLTLTSKPAALLCILEVEKNTQAQRWGEERRIAVILEIVQMVVVWHEAFSVKHQGDDQTQILREAERFWRARRQSAHPETRREKREEFRLSNLELTTLKYENFPVLQIDTVKEWTLGQDTVRIGLEYSPSLNEPAYNLKQVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ38</accession>
    <name>A0A8H5LQ38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ38"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="373"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5365241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="631" mass="71473" checksum="7A7397E256E8D318" modified="2022-01-19" version="1">MNDPGLDEPIANTADRVNSTYDDAQSISEQGLTRRKGKEKALKQRGDPEEGEAEKRRWFLFTAFPLIAGTLGPLANLFSVCALVQSWRIKIPSGERISDPKWLTALNSISLATALAANLVLLFNFAHRIRYVIAQPLTVTLWYISASLLIIPLCLIHDIASSTIHHTLSQSFHYGILSAVLYTLMSTLLLLHYIENIMKKRTRSDPFLSHLTMPQRTLMLQTISFTLYLALGAGVFAALEGWAFVDTVYWADYTLLTIGLGSDFPLKTSAGRGLLIPYAGGGLVIIGLVIGSVRGLVLEGAEERVERSQMRKEREKWIVRFREKEGHGKEKRGEGNEEDMERRKAEFEAMRNVRYRSKTVRRYTALGVSFFAFLVLWFIGALVFWFAESNQSWTYGTSLYFAYVSLLTIGYGDFVPQSNAGKPFFVLWSLIAVPTVTIFISNMGSTVVRWVEQGTLWLARWTVLPEKRHKANSGKGKRNTGDTDEEYHRGPRGIEEEGLRGEIEKIGERVEKAEAEHGEATGLPARLAREIRNLAKDVGRKPPRKYSWEEWSRRMKLLEEEDDNRSRRRDSGNGTSRDKIHDGNSDGDGENWGWLGEDGPLFSRMGETEWILGKLCEKLEEVLVERVNREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQM1</accession>
    <name>A0A8H5LQM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQM1"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034721313" evidence="1">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="342" mass="37515" checksum="C99132BA372FD68F" modified="2022-01-19" version="1">MTPSLFRAFLLWGVNIFNALQAASQVTPGDFPVVINSTFPLKLAVNPLCGQLSSQNFTEINTGIIPLSATRTIVAFGDSWTSNGANGTVPVPPIMWPPSPSAGSRVNQNRRASNGFIWVEDWANMASAKLLNYAWGGAVIDNFAWNTTSPNNKTSVPRTDFVAEANLFFLQGKFLDSLVPSQTVYTVAFGINDEGQFELAGGDWNRAYNTYVRSWISDHFGPHRMLKQSSLFQVTKLGELQAFGAKNILIHGMYKSHPNTDILQNRVFAYLKESKAVNGTEFAFVNLETLFTAIADNPAAFGYRGNPTCLVSANTIVGGCNDPDHSVFWIRKLAYRLAVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRM7</accession>
    <name>A0A8H5LRM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRM7"/>
    <dbReference type="OrthoDB" id="3045162at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="19090" checksum="46D40ED06BDE78C3" modified="2022-01-19" version="1">MNYSLNVQLNQAPRTPSRPVPPVQPQPQPQFCHAHNALPCCQHGCLHGVPYHHPSADYNSYRDYSQGHPNVPPPQPSSSKTNDVGQPARTSVLSMLGSSAMRTATDFFINQEVEVTLKSNRIVAGIVISSLQFFKKLAGFGYKVEYRSNNGQREIEPFPPENLRPCGPFSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS53</accession>
    <name>A0A8H5LS53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS53"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="442" mass="50381" checksum="F1A7CD50E38FBEF5" modified="2022-01-19" version="1">MPSARQIFVYISLAFILLFFILYPVADRLSEAFPDLVNNDENRRVVIVGDIHGMHEKLLELLSKLSFNPSSDVLVSVGDILTKGPHTGSMAVLDFLASNNATAVRGNHDQKVLEWRSWLNWIQSMKGGQAWLKHAIKEWENAQEKGEEDIEDWVDWKMKHDTIHRKWWRRVPNRQFLGDHFEIAMEMSTVQYDYLKSLPLKLHIPHAHAFIVHGGLLASDPNYKPTHSRQPLAKVPKIPKHLAASGQNSTRAYLRRAQEDAILTQVPQNMVTWNVQNMRGVTRKTNQVTKYGISSVFSSQRSDGGMSSYRDKEGRPWSKLWKNSMSMCAGFESEDRGSLPCMPATVIYGHAASRGLDIKRWSIGLDTGCVYKRQLTALVLGGKDNVLSNLSSRSTFSDDYGLDDDLEDDYDNLENKNTSRQKQYRRIRFGDNGWGRIVSVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUM3</accession>
    <name>A0A8H5LUM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_001853</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUM3"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042324425" description="S-adenosylmethionine decarboxylase beta chain" evidence="18">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042324424" description="S-adenosylmethionine decarboxylase alpha chain" evidence="18">
        <location>
            <begin position="77"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="14">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="14">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="17">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="16">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5370640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="440" mass="48547" checksum="B38E35549206F831" modified="2022-01-19" version="1">MAEETASGPFEGPEKLLEIWFAPCAAAVPDADQPEHGKTGLRKIPVAVWEDMLNIVKCKILSTVHGAHIDAYLLSESSFFVSPHRLILKTCGTTLNLLGVPRILEIAATHANMPSVYRCFYSRKSFMFPERQLGPHRDWSQEVQFLDNIFPNGAAYNVGKVNGDHWLLYLTNPTSDLVKQPTLKDPYPDYTIEILMTELSPAACRPFSFSPQESSSSSSSEHAQALSASLGITDIFPSHLTTLDAYSFTPCGYSSNALIKWGDDPAYLPSSNNVNGVSPAREGYYTIHVTPEEECSYASFECNVPLPAERPASESTSMPDLKNLLQRMVSRFLPASPASESTPVPDLKTLLQRVVSIFQPGRISVTLFISSEDEEDSAGDSRVDAAQRAFMNALSARTVKGEAASEEGKKVYRRTNKINYEFEGYDLAFASFELFPSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWE8</accession>
    <name>A0A8H5LWE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWE8"/>
    <dbReference type="OrthoDB" id="2972578at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24687" checksum="57110F24F5FE8C47" modified="2022-01-19" version="1">MSNPPDYQCATTRISRIWLLLQFARSAAVTQTLKDVGSCPGCGRLLYNPFGGLSLAIDGFSPFKWRFHDYHAAFDLYAHFQSTVLSSFVIWNGEQYYWLSDADAIKTVCNSRKIFEKDLPVYEKFLNFWGSNIISTEGNEWKLHRGVARSAFNEVNNALVWSETTHINSQWMSNLKKEVEVDLLEDSRLITMQVIQGAGFGRHPTWAEASSKQSDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY32</accession>
    <name>A0A8H5LY32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY32"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33702" checksum="960F85DE042DEFDF" modified="2022-01-19" version="1">MLSLLPVELLYEIQLYALSSDLPLTCRRLYDVYKSASNYFQAQYIFYHALTDHRTNTCRLIPPSKPEGKPQLPSDVYSRVLRYPLCSLPVLHHIVNYFKNYSYDHLLIGTNTPELPRRLFRNLQLPPKILKSTSNTEDPFGWSVEHDPLPFLQVIYGEPPSSYQPLSLPLPPPNPNSHSGYALTKAVQLSFVPLVSFLLSRGALPSCKDGLTMMVAIRQKDLGMVKTLVERTDYSSFASGNGSTKRRRLPDRLTVTAPMLRMAVKVGAQDIIDYFMTEKRVIPDIKTLYLLQNAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BBK5</accession>
    <name>A0A8H5BBK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000425">
        <property type="protein sequence ID" value="KAF5319876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BBK5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5319876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="822" mass="93933" checksum="8FC4BB7C1BBABD04" modified="2022-01-19" version="1">MYIPCLGRLLRKEKEYCDHPIHCGCIRPFDINVSSNNTNNNSESIFNVPILNTTNYEFWNYAITCLLEAKGLSRVASGTQKCYVNTSPTKTGNAPSFPEGFVQVPDEVFNALTESKQSSYNQIIDTFTNQWNQYQILVKKHDRELVETYKLQSSWDDKDEQALGYISSFLPNDVGLEMREFTREEIDDNHCAKAKGDYTLHMLWEKIDKKYSSPGPTSWFLDFKEFMSCMLDEKKDPANQIASLGAVLTRLKAYRFTVNDKFRALFLMDRIPQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKRRTGDASQGGDKKKKTRRSKKKGSKKGAAHLANPEVEADSDSDDDAPLMVTAFMANPFINAELDPIKINCFIDENNNSSLKERVKQNLAKQVRPQMISGYFILTHYERLMINELTQETVDFESFLRVEARHQMTCKLAEIWDYTYNSDGTHTEPYLRAKEDLNGDKDMTNQWFDHEGTICPIQKQIKEEVEYFCHYIMNKALSDMRNHKWIPQQFKKLFYQPTCTHRLLSRGCILQEGYYEISQDDKSEFQKEVDQSLLMTLLPMHRKDNLHCLKSKIIIPESVNLSSTLTDYDIVLERQWKGPPPDEGNGDHQNIDDGNGSDENSKDHDPGSHQPSDPNDSETESIQSREPTQPPAQVPADPVPVQGPQPVNPRNVDLTTGRFINREPNPNQTRSSDRQSRPNWRITDLNMQHSRDIPRGGWTRVTPRVTRSQSCATGSQTVTDPTPSTSQVREESDNEDQSETEAGSSGEIAEFLEEDVLEQHVQQGGVWLQNYLLSQAFVNNKQGSSSATPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BH43</accession>
    <name>A0A8H5BH43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000402">
        <property type="protein sequence ID" value="KAF5322953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BH43"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5322953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="39181" checksum="48E08D7C84A8D941" modified="2022-01-19" version="1">MSSNNAINNAESIFNVPILNTTNYEFWNYAITRLLEAKGLSRVASGTQKRYVNTSPTETGNAPSLPEGFVLVSNEVFNALTESEQSSYNQIVDTFAHEWDQYQILVNKHDRELVETYKLHSSWDDKDEQALGFISSYLPNDVGLEMREFTRDEIEEDPCAKAKGDYTAKMLWDKIDKKYSSPGPTSWFLDFKEFMSWTLDEKKDPANQITSLGAVLTRLKAYGFTVDEKFRALFLMDRIPQSWGNYAQFTLATIKPKNLTMAHVEGLILVEYKRRTGQSSESSLLTRITGDRRKFDSAPNWNNQKVGSSKQKNQDKGKGKQPKPQEPSKTVTTGDAVEIYTFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BIJ8</accession>
    <name>A0A8H5BIJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000387">
        <property type="protein sequence ID" value="KAF5324064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BIJ8"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5324064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28563" checksum="C4B4B6E0D594CABF" modified="2022-01-19" version="1">MRGEARDSYGTFKPSARETQAQTKIEHIKMEGALADIDKYNSQFKRYADDTGYNDKVLMKYYRKGLPRGLVDWISYLSTQPRNLAALQKAAVKQHMIWLERQEEKTSWNKPRREEGQPGRRSQGTGSSQTRSMEVNAFQDNTPGASSITKYPPKLTPQERDKMRKEGRCFRCRGQEHMGNDCPTFPSTPPTTSQQHDLDTLHKRTAVVTETSDSKVNTTMDNISELTARTGALSGEEKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRS1</accession>
    <name>A0A8H5BRS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000372">
        <property type="protein sequence ID" value="KAF5328029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRS1"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5328029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="33300" checksum="F979BE99DCC59692" modified="2022-01-19" version="1">MFIMNSDSDSEYKSWTHPLEFYILPTDTRNSLNQQNALDLQGKIALVTGGGTGIGLMIAKELSKNGAKVYITGRRLEVLQKTAAETGLFPLQMDVSDKQSIANAVKVIDEAEGKLDILVNNAGIGGFRSELLFGKPAPDGTKIGEALFEQDSFEQWTDVFKTNTTGPYFTTMGFLSLLERGARTREGETSSVIIISSVGGTIKVTSGLIAYSVSKAGVNHLTGMLATQFALQKIPIRVNCIAPGLFPSELARELVDVAMEPMPGFFNPAPPLRPGRQLEIGSAAVFLSSLAGEFVNGIVMPVDGGLLLVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTB1</accession>
    <name>A0A8H5BTB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000353">
        <property type="protein sequence ID" value="KAF5328923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTB1"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034730439" evidence="2">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5328923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="466" mass="48461" checksum="BC4841689EEC50A0" modified="2022-01-19" version="1">MKFSASASASLALTALASVSAKPINLRRTWPMPQYQPQDMAGMGSSNSNSNNNVMNMDHSSNSNSNNTMAQLNPHCANDTANGGNGNFPGALYFMTNEPDGSNLVIHGINNDGTLTFTGVLPIGGVGSKEVTDPVDVDPLGSQASVKVSGNSIFIANAGSSTVSMFNIDPNDPINPTMAGFPISSGGEFPISLTVSKKSGQVCVVNTGAVNGISCYTSDPKLGLTPVPNTIRSLNLDQTTPPSAPINTASQVVFTDDGQRLLVSVKGNPGFVASWDVNEDGSLSPDFVKNTPSDGGLLSGLSNIGKSKDIPALVITDAALGVNVFKFDDNQVKSKASNTPLPIDGQNGISWAEFSPVTGNFYVTDKGTATLTEIAVADDLKASVVGQTKLIENSATIDLEIATIGDKDFAYVMAPNAGVINVLDLQSPGKVVKIEDKDFCQSLSKAGVKFDPVNIQAMNAFFVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C014</accession>
    <name>A0A8H5C014_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000322">
        <property type="protein sequence ID" value="KAF5331507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C014"/>
    <dbReference type="OrthoDB" id="2431447at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5331507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="194" mass="22445" checksum="C5DAC5CE2267FEC4" modified="2022-01-19" version="1">MTRIQHDTPKKNRLVGVIQARKTIAQAAELIDMPLGTAKGVWARFRKTGSTKNRPRSGRPSKVSDSLRRQVVRLARKDRKMPFREIGNLVEPQLSATTVGDHLAQENYHRRVARKVVLLKKTQKVKRLAWARTHRGQDWEKVIWSDESYVYIGDPKGRVWVTHRPEEEWEEDCLIPTFKQSSIRVMVWARSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C083</accession>
    <name>A0A8H5C083_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000321">
        <property type="protein sequence ID" value="KAF5331748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C083"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5331748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="754" mass="81785" checksum="AC335C05A3041401" modified="2022-01-19" version="1">MLLSQHNVTVHTVSELLWYLQRPSVPSETSPESVSNAERDVSNSLQDSSMEILEGDLSQLGPSPPRIISIDRPRSSLFALIIGIDEYLDRNIKNLSGAVADADSVRDFLLQDVGVPQEQIKNLRNSEATRLAIETEIQNLSGSSAIKENTPILIFYAGHGAQMPAGDLPARDGKIQMLVPYDFALAGSEDERGQGVLDVRLSSLLADLTSKKGDNITCIFDSCHSGSGTRGDEKDHTFAVRSIELPQSYTIPPSIFPSHSDLESSRISAIAKGSENVGLQSHVLLTACLPHQEAKERHGAGAFTSALLTLLREQGLDQLTYRGVIANLPDLPLQNPQCEGVHQDRVLFNSKVPSPRCELYPVKRSVDKPGHFMLQAGEAHGITAGAEFDIYSDKDMTSFICSVYVSGAPSCFNALCTIKPEAKSSPALLQEVDFPESAYALQTRAGVRKPLRVSIPLAEDFIDVFRLIASDMQSGDNAILLVDSEDEQPDLIVSLHSSPQSLAIAHFKIMSLLCRQHGFTRMPFDIPLDGADSAKKFHHILRSAAHFYDHLHCSANSKSEHINEGTNIEIDCFQLKDTGDLSSFEVIFAPDPEGKNLNIGGVLLMFIITMRFFAVVSALAAAGFATAQESARFGSVAVSPCGGFKGGNAITLTYNATTAIQQGNVPESVSFWVQGVNVTDGVQTPVSPFFRLAHNDNFDSQADPIFTTQITVPEPFGDFINAPFFVVTAFIIHGSDGLVEFGGVEDECPQIQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C141</accession>
    <name>A0A8H5C141_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000300">
        <property type="protein sequence ID" value="KAF5332904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C141"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="23546" checksum="9A8C4D1022A18E25" modified="2022-01-19" version="1">MTSFFSDRYLSHPLGLSTHDFNDLNLSGLPFQVRTSTTSQNFSVYLLQYWKAVPLTSCTPSPLPDCPWPGMVKKEENEVAFGVGTDGILMSPGVVGSDDPDNTLVEPKDLQANLAILESKAPPARIRTATLIRKSRKMARSKEDQLFWQVRELQRLLDKLVRTHASTNVKLGAVTLEKELALRERDLARIERDLAQERVSALEAAILGDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2I0</accession>
    <name>A0A8H5C2I0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2I0"/>
    <dbReference type="OrthoDB" id="3221808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="87"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5333801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1063" mass="121273" checksum="A594B00240768111" modified="2022-01-19" version="1">MHFNFKWLTNVFKSPRSSKAPGEAHAMNNMENGFSANHSRPGPPDPFLAFADPFFAPLPPSGPDNDKKPSQKRFQPTADDQACAGMWSIYIGEAERYDKSLVEGWKGDMEGMVIFSALYSASLTAFLIESYKTLQPDPAQDTVFLLSKISQQLSNSTAPLSEPPSFETPASAIICNVLWFLSLALALTCSLLAIFVQQWTRDFIHKANLRPSPIRQARVFAYIYFGLRDFGMHSFVDIIPFLLHLSLFLFFGGLVAFLSPVNRIITYIMIGVLGVFLLIYTALTVIPLVWLNAPYRTPLSGALWRLGNAFGSFLARKHDLDHCQDATLSEALLEKSLQGTSERDRQALVFTMQSLTDDDELLPMIEAIQDVLYYDNPNFFYPDYIRRANVDLIMPLIMSDDPEVNIISRITQYLKRSQVVPAPKDPLKDSLKDSPLHGQGSMPPVYSLVYTLMYMLVTPRQATDKSQMLIEKHVQTHLAFTEDLLLHIVRLSWHHKSLSSTVALLRFRWISYIRDVVSSISRIVDEMKKANGQNIPASALREQISHLNEIWESLDESRMNKGGIGILSSCNPTRLIISDYHKLPRTFKVAGEALKKWGMSVECSTAVPEELEAALDKLKQDDTWDVTRSTILFEYLQQVLTREHRSNQTSISELPHDFERIWDIIRPPHPSLYLVDLPMELGDNYMFPLETLSRWLLDQSTAIDDKVDLWMQKSMQLFFSIKDAQSNPDLAIWGRNLFLRYFSRRAKEAVAKPPHDSDWINCFISYQPDSRRLVGECVIQNIRHETTPESLTCEAAFLFSLICAPIYKSPALSELWKILNDSDKTSSTQNTDISFLRITLSLINIYQTSWHSRFGDEEELQSMEVTLLKQYLSDDFISPLSRETLRPSLWVALYAEWLDQLAQNRPFAKLDLCNLFHMSQIRFLLGTTDLEVNEKLQIRFAEMYSNFITDMVSEDAGSGNYLDRVHPSVYDFFVIVKGPFFPAPGQRVFVWDWITDLKCAKTIMKAIQKYRSCFDTGEEEIEGQSTLFARCLEVRGQLPALDSDSEDVQGEGDETVEKYSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4L1</accession>
    <name>A0A8H5C4L1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000282">
        <property type="protein sequence ID" value="KAF5333862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2634326at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1899" mass="213721" checksum="F73DCD72BD7E4496" modified="2022-01-19" version="1">MTPTAEELDTNHQLLLHRPLQKKGRSPTAYDASLAAVLPGGSLFLTTPYQDLPVYQVEPIVEGMTMRRDFRFGQYDYLQWPQQWCQQLCHIACILRRPPPGHQFDVMWWTPTIDCFKEECRGIASGLGKLRAGKAEELRLLVAELRGRCSLFIASHENETEVELAQQCSQRLLERMNRLHSLLLTFRQICYTIASLQRLFLELHALLEYCTIYKPRMAGKSLPASIAAAVVGAWTSNLEAAEALFRAGIPFWFLRRVDEVPAVSVGKLASLVVPDDLCLDNAPFPEPIIYRTGVPNTELQYSAIHKHLNSAFNTYSPFESSAESRLQITPPSALVLSGPQRTTPSKSRHHPYPKSPKNASSSARDKFHLVSHSLFLTSPCWGPALSRVNQSNPPVPIQGGYAFPDPSLFVTVQKREKMFKYCWNWLQFRDVLLFRVTQPSPRLIPNSTWRQILNGELTSTTQPSSSSSQRPSRTASAKATARDLLGNCLLSTGVEVDLENPPSFVMWRERSFSEPSDISEKVAQEIIWEVAQLNFRCELRALDQALTPRLSDEQRLEQSARLSACFLGADVESILTVEFDWADGGFAAKVPSSRKKALFGLRDVMKRWPKFNERCSTASGNALEVTFYNDSALEVFESDVHRLLEGRATYFTTRVPNMYGSRDDALGFTSSEMGRTQRTTTCTKCSEYPNGHPVLSRDYAEHLLNRHNDAQTPSVVAPTASTPEGSMDQLTSLLTAVTVSDPGPDIHKQPTKLFTSREEFQRDIKIDTSGNRIGFGDIEQGLNSVVNVQPPTEPPASHHPSLSRRASRVSLSLIRKICNPKLVRMVRSINAVKDEAISIRENLLQLTRHNLDFSDKQAVLKRQEALKQANTRINQLSATLLSMRKLSDPSYTSAAEEARSELRKADSVLSIIGMDLPSPEGSSAPTPFSSDYLFENPLAGVGVATRMVIFLTVACALVIGISHRDCDFIVSAVWNIVAAATSLFCPSSAAPTSEQHVQRQLMAQLPSSLYTALNALRLDSKTTVFAPEFSQTAVKAQYPDQCNNMIVGKDGRSACGTSLLHARNGNMRPIKPYAVNSLQEHLARILANPELEKYCDTAVDEALRKVNGEINGGASNEPMTSVFDGDFLRQFTGPGGVGTLFIDRGDKARLALALQVDFFNPNGNRHRGKTASIGLVSFAILNLPHEIRNKPENLFLAAIIPGPREPNDEDFSNYMTPIIDMCLPGWKGVHLSRTGKHQEGRAMQYAVVLSVNDLPAARKVAGAAGHTSGWCTVCQNYHRTYNTCFEQWVKHDVQELRRLAEASRDANCSAERQAIFEASGVRWSELWRLPYWDPTKMLVVDSMHCVLEGLVHYHCRHVLGINAEAAGKEAAMDPAFHHNWKLYDELQVPKAYQLDGNKLDSQLKSVSNIHDLLEAALECNEGVPDTMMLRKRLSTKRLPPLRFVAWSLGIHETRDREKFAQYAKRKNPRKAMRKVKVIFNNEVITPDVPQPRKVKVIFNNEVVIPVFQIKSIDAFVDVLIEWRLKMPFVPSESKSDSHIDVKSIQHIQHVINNTSVPSWVNTVPHNYSEKVAGTIKADEWRTLVTIHLPIALVSLWDWDEDKASLRTRKVLDHTMKLFQAVNIVCRFTMSDERAKAYVGFLKEWVDDLYALHPHTQGSRRIRPNVHVAFHIYDFLKLFGPVISWWTFPFERLVGALQKINTNDHIGGEYFILQSSFSFILTSNFTGELEQTILHTFSRATNFRRLVSRPDCDEMITQFQELFDKAYGSRSDQFESYNDFAPNSKTDSHAYYKYAGVFYSRAKTHLGNSFVRYVHGNQSHVGSIQEIKNCGEHVVFIIQRQLPLPSGEREPFRFPWYPARTFSTKTSTELHTISPSAVVCHVARYQYSADRVVVVDLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C670</accession>
    <name>A0A8H5C670_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000235">
        <property type="protein sequence ID" value="KAF5335871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="8"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2018"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2364"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5335871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="3104" mass="353654" checksum="38B3AE2E7C8630CC" modified="2022-01-19" version="1">MSTLDYIAYHVFLPPKLPQKDDYTVNNETALCRTVLQSATKYLHSGLVDEQYRSDWRALVGMLIYLTKSTEEMDGDVLENTFSSMKDGDVRACLVREQNAGVIFRKRAADVIYEAFEVRPPTEKVTSAQGKLSCTYPGPAISVPLPHFENPDFLRELSSFLVQMDSDTLDSAATSKKAGTEITEERDSAHPRYITSLLTGILRGLGKPADVHRIQKRIADEVLMDKARIPWRRSMVWLVIRVALQTHFARIGDNNEYKVFMIQLMCDILEDAVKARFVNDMLFAMRAKVAIRVSKLGSSVPNAVLERAKDVSAKVETLLETRWAKIQEAQAQSPPWDGAALRSWAKADSHLTMPKSRRYLLSTLSRKGGDSVPDDFSPNCSPRPLQDLKQFELCTQSFLEKAFASETYIALADLELSVQSNLDSWIDKNIKEPLVPSILFDIMVAYRSAASGCYVFPEDNSIMILTLFELWVALDKAVVKRVPLLAEFSPEVPLDLFEPLLLRKATHIHRLIQIHHYLRLRHEKAKFGSIFTEASYSNSFAVKFFNQTPAFQKLKTSIESNAEQKRTQKRQEWAQKRQEHKEKTDRARQLTCIYETHGQRAQHSGRCERCRLFAQASRLEITVHEWPLPSDSNVAKTVIFEMKCPKDFRIWRETTYTLLNDVCQAQSGPDPAGGQPSSHLYQYCNQFTELRTKKEEVGRISLASTTKSFLAAHYKSKKIAKASAERDVIVPNGLSWQLYDGTVNRWPAKRSFADANPTVAHMCTLHLPTSYTSYDSLQGFIESVAQNSNLAIAHQHYCRDSLSMHEFISFATLRSGQRLQWLNIAKEIRTRVLTFHNEEVHLLMTQAACQVGNIISGELERHLDLKSPAFCHTLLGELKKLLVDVQTNWMEVTTVRTIIMLGGRVLASIKDSGAQEEAFSLMLLARSVVYTWLTSLIKNPVDSIDDKLVSERQRTVSELALTCLLTYDVDKKHLPRLLTTPHDVSIFLECLIHRFDNTLLSSDVLPPHIQTLLHRTRRLSHFVEPVLRSLLLENRQGVDQALLSVWPAYRLCLDIPWSCLNTPNNRWVCASTKALASYRQQNVHLNILEGQLLVDGKSLTRLPKTMTEHSTFRRLFGNRLLEVFPSDSKDGLAFSSRSDIYGYQVHFDLRGSDLVIQAQHLKSHARLELIPQRRLFGDLPELMVKEYFHWIDLEQREIELRPYTSPWVSSVGNWRLKLRGEDITMVLDGKQLVDIHSKSFQMISGYLNRMEHSQFLTVTYSAGPAIDVDLPRFQLSFSVNSEGSLECITFPGMCVDNYSSIGTLYGLVNMLVLNPSVPTQPRRILIPNGRIRTRIKEHHVEVSVDTNPDEWKRTFFVDYTIREDLGYLEGDGSLTSHFLRAYLHALTSYCLPDPLTGRTGTEESLAILTSARSFSIQNLTDAQFLNILYQIASMTPSRTYYPENSELMQTVHWSNLPVPVLSQHPSFFPETMAILDYCHSLLKELQVDAYRDIAIDIPRWHVKSKQKLWLRDYLRNFKFYAAVDVESTAKDYSTDIPYTSRDLDLTGEQIACTVASAIFEPPSSPFPSISNFLKQWRALTRRDDVSLSLSYNKEQWLDTHVLSTHWLTLYDLCRDPSVTREEKVYQITFSFPSLAFRDKSAQKLLSLLIEFTTNPSFSAISAPSFPSYALSNGVSPKGKQLDIILLDARIAGFDWSSVGLVQRLDESDSDYEERCDEQFGEVISQLKSALLSQWPGSPSDDVKHASISSDRLMKGVRQLFESCDQNKQYMDHVDTVQAILNSVILSPLPSTSSQLQSYKIDVAPSPTLQSNQIVRTGIDYLLRRSPPSVDCHESKFTDLGTYLRRTPPASSGISQELLSLTQQISGDSNFTQKLLGKALRGSSDALSHSQTSLQRTTGLDLSCEDEIIRFITEYDKSCEREYALVHAIVYEALSPKSGPEQLLQTAGLWPRVTPYSLLRLLSYDQRSYLSDSWKAVLTVYAKKISERQRSQRLLSQLASEDRDGVLQEMANSSPKGLDDIDWLLVQISSNFLARDVQVDVANEMESPSSSENSVLQLNMGEGKSSVITPMIASSMADGGKLVRVVVLKALCTQMFQLLVDRVSNLVNRRVYYMPFSRRLKMDQYKVAKIQALYEECMKKGGILVVQPEHILSFRLMGLDRIVESGLQNLQGEAEGTVCRQLIESQRWLQKHTRDILDECDEILHVRYQLIYTLGKQGLLEDHPNRWTTIQEVFSLLLTHAPRVRQEFPLGIHIQDEAIHKGDFPAILIVSADARALLFDLIVTDILAGRLLNYPFERLPKELKPIVRKFLCNRSVSAAEVRLLSQYCQGSSSWNGLLLLRGLIAYGVLAYTLNERRWRVDYGLDEHRTLLAVPYRAKDVPSLRAEFGHPDVAISLTCLSYYYRGLTEGQLDTCFEMLMKSDNPNLEYERWARNVPEVPRTVNGINLRDLIQRHNVLIPYFSHNHAVVNFFLSEVVFPKYAKRFPEKLATSGWDLAEEKENFTTGFSGTKDSQYLLPATISQLDENSLGQESTNAQVIEYLLKPENNYYHCARGANNEPLSASDFLQLIQVIGQAIGKQIRVLLDVGAQILDMSNEAVARYWLELENPKDVQAAVYFNNRDQMMVLDRRKRNQKFISSQWRNQLDRCVIYLDDAHTRGTDLKLPKDYRAAVTLGPKVTKDRLTQGCMRMRKLGFGQSVMFFAPFKVDQRIREICGLDNHSPVLSSHVLRWAYSETVTDIEHHIPHWVQQGTDYIARQQAWEAFDKSERVSDLAVWRQPDARTLEEMYGAKDEEQRQESLTLEFGKGGERLKERFNILGYQVTQNMLDDMVDEEQEREVSHEVEKERQVQRPPRKEPAAHMLRDSVREFVHSGIVRDSRTFIPLFKSLNLPLNSTHRGLLSTLDFAITIRGSEPALNDFMRPVTWVISGGRTDDWTPALVIISPFEADQLRSEIAKNKVGLHLHVYAPKVTQNQESFDDLGFLTIPPISNAPGSNWTPPDPLMITQLNLFAGQLYFHDWAAYKQLCDYLGLYIPGDDSSRVVAYQSDGFVLPKDRRGEMKRLCPFETSPLPKLKELFGLRRKGNGYSFTHIGKILSGRALDKRDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C774</accession>
    <name>A0A8H5C774_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000231">
        <property type="protein sequence ID" value="KAF5336213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C774"/>
    <dbReference type="OrthoDB" id="2976650at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="361" mass="41607" checksum="B60CD643CF984688" modified="2022-01-19" version="1">MQTPLEQSNQTGEVVAIKFATEILPLDEELMIETDSKYAQTQLTSNVQANEDKGYIGVKNCELLKATVVSIRKRKQGTHFKWVKGHNGHDGNEAADKLAGVGAEKQSTDNICIRRAPALEITGAKLSTMTQALAYQAIRERKMKKEKRKNGPRRRTVQNLEKVRAQVEEAFEIVPKAEAIWRAIRHKDFTRKTRNFLWMTTHDAYMTGSLWQRASFSEELQEQAICKHDNQLEDMEHILTSCESPGQNVVWELAQRLWEKKSRKEWYRPGIGTILGAAAGDIKDEETEKLKSGETRLWRILIAESAYLIWVLRCERVIANENTQFSEDEITNRWSKMINERLKLDARMTNKKYEGKALSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7U0</accession>
    <name>A0A8H5C7U0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7U0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="205" mass="22726" checksum="EE79F4A5E998A972" modified="2022-01-19" version="1">MRKERGEGGRGSGLMTENEGDVRHQIDMTYMHAPTSFAIASSTSQTFTSSGFLSCSGSQGATRSSCWKESRWVLAIAYMFLTALLFFKTIRIPAVEILNGQARYGQPIGVLPKHCRPIVGLHPMYCIGSEDVETMAGMAVMPAAKRLTKLSERDEFFNKLPVKDEHGQLMGREEITAEALGLLVAGFDTTSHRNRLLHFRDPQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9Z2</accession>
    <name>A0A8H5C9Z2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9Z2"/>
    <dbReference type="OrthoDB" id="10627889at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="400" mass="45909" checksum="FD43C92A65D8BB1D" modified="2022-01-19" version="1">MDIAALLDLDDLNRLVRLAFRNRDREDPLYAPFLHLYSCFKRLVRGKLLRPEEPHTISLCPQLKLLVHQLVEEQLQEEEESLGQVLYRTPDFISLILSDIDELPNEVEEFLQTVFELKALHFMIVDPEGSPSRHLTLAEWLGGKAAIKVAGTILGNNMTQLILQGLLALHQYGDEEVFVVYEGGFIAAELKFTRPPNFSFPDGLFQLPHSRTADKRTLPSLIATAIPPEYRPSCTVELSPMFKFDPDGYITGLSRPMQGILQREYTSIQHRIILRLVVLLHLPRPQTLRIPLQQKTKADNELYGVEDYIDIWYQDYHTTYRDEVRAKKAADSGSHPHPQIPATPLHKREYSEAFADPATPTDSSQGYRTERDTESDDDDYEPTKPSKRAKMHRRKGKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCQ7</accession>
    <name>A0A8H5CCQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000192">
        <property type="protein sequence ID" value="KAF5338686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCQ7"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5338686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29428" checksum="28BB5A3562A71806" modified="2022-01-19" version="1">MSTQALDLQGKIALVTGGGTGIGLMIAKELSKNGAKVYITGRRLEVLQKTAAETGLFPLQMDVSDKQSIANGVKVIDEAEGKLDILVNNAGIGGFRSELLFGKPAPDGTKIGEALFEQDSFEQWTDVFKTNTTGPYFTTMGFLSLLERGARTREGETSSVIIISSVGGTIKVTSGLIAYSVSKAGVNHLTGMLATQFALQKIPIRVNCIAPGLFPSELARELVDVAMEPMPGFFNPAPPLRPGRQLEIGSAAVFLSSLAGEFVNGIVMPVDGGLLLVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEU5</accession>
    <name>A0A8H5CEU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEU5"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="103" mass="11650" checksum="F4EC8CF80151FCED" modified="2022-01-19" version="1">MPPTRSQGRPSIRVQLQQFRWRRVLTHFECQHEEAYILFGVATAAYQVEGAVENEGKAPSMWDWANKTPGAIVDNTTGDITDLQYFLYKEDVARVAALGINAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CI59</accession>
    <name>A0A8H5CI59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CI59"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="453" mass="50565" checksum="27446B1F99730055" modified="2022-01-19" version="1">MDRVFSFRAFLLPTMCFSPMRHRQPSYQVFSELLNTPQRQQKKSRELYRHQHPPESPSKRRVPGESSASEHIFQVNPNPFCLPSGPSSHVFSVNEDPFATPSQEVSLAASSNSTTSVPNENNDPVMQGQVSLQTEQAQHAKRNRSEAQRRRRRRERAEHTPVQNQWSAPPSQTSFPFALAAEDHYTSTISNSRSLDAATLLSNRRLLSPPPSFSGLNANADVDMIDSPSHNNNLHTTMPQRSGSGVNPQNGGSAVIRQADQLFEQYSHNNNPDTIVREHSSIRPDNFCIARRPYTEPMQRHDLGHMSVACNHCHAFHWEQERTTGGHFGTCCDGGQVVLTPLSEPPRVLRGLLEGQDAAAQRFRANITQYNAALAFTSLGADESTTLLTVTVQAIGCFGCMEIYGIYQVHSKRLPVSPHPMLNSISMTQLSLSNYGWKGIPMCLIPLCRPCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKC7</accession>
    <name>A0A8H5CKC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKC7"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="312"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="647" mass="74593" checksum="B6F2C7AF519B9A98" modified="2022-01-19" version="1">MPDNRCSSCVTQKTECTYQQEKQKPGPRPGTNRLIIPQSCRLLIAEILKGTPSESYLSRCLNDDASATSIVVKLAARIKELESENEFLREKPLHVQKISNPEDSNSQASSELVEKVTKELAEFTLPSAKEPVHFGESSTMMLVMTAVEHRKQVDSNLPDWEKLLEGTKRPQYWDVPPWLAPPRLDPLRYEFPDPYEIKRLVDAYFDCHNLFSPLLHRPSFERSLADKLHIRDEAFGAVVLAVCAIGSRYRYGQINSSDPNVMFVVSGIKWFHQLPIQRFAFAPDVSLYHLQMYCLAMIYIQNINSGPEVLGGWMITGIAIRLAQEKGFHRRFVVEKKPTPERELWKRVFWFLLFYDFNMGLTFGRPRAMSIEDFDIDFAIECDDEYWEHLTHPFVQPPNKPPLISFWNHFMKMYEISILAAQPLYSVRKIANKDALQKVVSEIDSALAKWADSIPTHLMWNIKHEDENFFKQSAILWACYYWIQIEVHRRFIPRPGEEPELSFPSMTICANAARSCIHVVETCLQQTKDVTGHFMLPVILPLFASAMILVINLWRGKQVDPDFDPRPDLTVIYKCIGLLRMYESSDITNAVMSATRPFFSSSQENFAFGIEDSAMFSTFDPLDLQNRLRHKQIALEKAQAFSLICEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKJ8</accession>
    <name>A0A8H5CKJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKJ8"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="181" mass="19525" checksum="6DC794073DFE5E5D" modified="2022-01-19" version="1">MPSLQLTFAEPQSHPSRLLVVSGPFTGRLSKDNFLFPSLSTFCHQGHQYRRHHTPPPLLEILTFQLMVGRDRMAPMGGVIGRNAGGDIKVKSQTWLEVNPMFSLVGKLAVVTSSSCRIGAAIALRLAEEGATVAVNYANSSFVSEKKKIVSTIIAQGKGDDIAIKANVSTPKAQYSSSTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKM4</accession>
    <name>A0A8H5CKM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKM4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034725778" evidence="2">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="465" mass="52203" checksum="264DCC3A8361EC79" modified="2022-01-19" version="1">MQFKKNFVFFIVAAVLSTPSLARPVNVPDVGDLALPSEEVHVGRSEIVDFQKRRHGDSGERGRGRSRSRDGLVARKHGDSGERGRGRSRSRDGLVARKHGDSGERGRGRSRSRDGLVARKHGDSGERGRGRSRSRDGLVARKHGDSGERGRGRSRSRDGLVARKHGDSGERGRGRSRSRDGLVARKHGDSGERGRSRSRDGLTRRRHGDSGERGRSRSRDGLVARKHGDSRERGRSRSRDGLTRRRHGDSGERGRSRSRDGLVARKHGDSRERGRSRSRDGLTRRRHGDSGERGRSRSRDGLVARKHGDSRERGRSRSRDGLTRRRHGDSGERGRSRSRDGLVARKHGDSRERGRSRSRNGLTRRRHGDSGERGRSRSRDGLVTRKHGDSRERGRSRSRNGLTRRRHGDSGERGRSRSRDGLVTRKHGDSRERGRSRSRDGLTRRRHGSHSRSRSLSARGLDSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL75</accession>
    <name>A0A8H5CL75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 12">Catalase</fullName>
            <ecNumber evidence="3 10 12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_015871</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 12"/>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL75"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034142894" description="Catalase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="60"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5342712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="699" mass="77018" checksum="B795B4B9EAFDE562" modified="2022-01-19" version="1">MRSRLFFLQVSLWHVLFASATCPIADSQGDRLVQRRSTGLPGDDGFLDQFVVNDTDSYTTTDSGTPVDDTHSLKAGERGPTLLEDFVLRTKITRFDHERIPERAVHARGAAAHGYFESYADWSNITAASFLNQAGKQTPIFLRFSTVAGSRGSADTARDDAIQFPDLIHAVKPRPDNEIPQAQTAHDSAYDFFSQNPSTLHTLFWALSGYGIPRSYRHIDGFGVHTYRFVNADGASKLIKFHFKTQQGKASLIWPEALALAGQDPDYHRKDLFNAIAAGSYPSWEVSVQIMDEEDVTRYGFDLLDPTKIVPETIVPLTPIGKFVLNRNPINYFAETEQVMFCPGHIVRGIDFSDDPLLQGRLFSYVDTQLNRNMGSPNFEQIPINRPRNPVHNNNRDGAGQQFLHTNTAPYTFNTLNNGSPKPANQTQGNGFFTAPARRIVDASYVREISPTFLDHWTQPRLFYNSILPAEQQMIINALRFELAHVQSMHVRSNFIAQINMVDNDMAVRVATAIGIDSPSPNPTYYHDNTTTGLSIFNGTLSTIAGLSVGILATTNSSSSIAEARALAQSLASSGASGIVIGETLQDGVDLTYIASDAVLFDGIIITDGTQALFESGPTSNTALYPPQRPLSIVRDTYFYAKPIAAVAEGQTGLLRADIQGSSPGVRMVNSTTDAGFLDGFKEDLMQFKFLDRYPLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLK8</accession>
    <name>A0A8H5CLK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLK8"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41365" checksum="B6D8557AAAFAEEDA" modified="2022-01-19" version="1">MPIRLGFVGLSTQGWASSTLAAPLFRPPLSSKYHVVAVSTSNPESAARSAKKYSELGSSATGEEIKAKPYYGSTENISSDPDVDMVAVSIKTTMHMEAAMKVIEAGKDLFLEWPAGRNAKETEELYEAAKRKGIRTIVGAQFRTSIFARKVKSLVETGTIGRVLSSTLIISFGHDAPFWGKYTLPSHAYLLDEANGAGMLDIGAGHALEMFQFVLGPIISLTATTHNPFPRSIVLNPAQDFQPTSQTHPQTVATQAAVSGFLANNTVFNFHMQAGVAKTAIGFLWLIDGEEGSIKVEDNKNRLFSPVDPDVFVNGKKLELEREVDKLGMVRRAWDAFAEGRVGEYATLEDAVRNRRVIDAIKESGRTRQTICLQINVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLS0</accession>
    <name>A0A8H5CLS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLS0"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034542676" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="108"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="345"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="81623" checksum="17E32B6C5DD7B147" modified="2022-01-19" version="1">MSVPFFNLLLAVWFFLAAQQARCLDWTATPFNPPSFPLAVRTPYLSAWLPQGKGIPLNGGWPQFWNGQIVGWAGFIKVDGQAYSYLGDPGVQAPFQKAVQKSSHFTSTQSVFVLSAGPVDVTVTFLSPVEPDDLVKQSFPFSYMAISCYSADGGSHSVQVYSDISGEWVAGNTTLTVNWNTTIQDALTHTVALQDQTEFVEDNDRILQGSAFYSTLNQASGLTYQTGSDVDVRATFINQGKLNNTQDTNFRAIQDNWPVFAYAHDLGTVTSASTNPVVIAVGHVRDPVVHYIVENGELQNRSALFFNQFTQPQDAITSFLQDYNDALSRAQKLDSKVEADASAISSDYAGIVALSIRQALASVEITISKKSDGSFNASDILIFMKEISSDGNTNTVDVIYPSWPALLYLNPLMGKYLLEPLFLYQTTGQYPNKFSVHDIGAHYPIANGHNDGKDEVMPVEESGNMLIMALSYARETGDNSQLQRYQNLLDQWTQFLIEDSLIPTNQISTDDFAGPLPNQTNLAIKGIIGIKAMSEVASILGDSAKSSNYSSIASSFVSQWQDLAASSDGNHLTLAYGNTSSWGLSYNLYADKLLNLNLFPNSVYTMQTQWYKIVANNFGVPLDTRHTYTKSGGVTSDWEVWTASFMTDSSTRDLLISSVHKFASGGTSSQPLTDFYETIDGAPQGFRARPVVGGHLALLALNVTTTATGTDPGSIGSNDPTTKDNSNGGAFAGVPFLSMICLISANLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM89</accession>
    <name>A0A8H5CM89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM89"/>
    <dbReference type="OrthoDB" id="3058388at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="716"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="859"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5343869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="939" mass="104723" checksum="1601F8497472DB59" modified="2022-01-19" version="1">MVEHDRPDPTLVLPDGSRCQHKRKQRIDGSEDATSSTHQPRGMQKARKTNKKSTPRHTLSEEGAEPTQATTSEPDPTPTLPDPTLATNPTYTPTPNPTPTPTLVNPGPTVIEIDDENETTDLKHRLSMPGRPKSSCVADHPQFQKKESLVYTFLIMVEPEHKEGRLVSCEMACAFCSAKKLPEKKWKWNISGRGSTSNFLNHFKAKHTNVWTARNTEDMSARFPNHSTAPAEGSTQQLTLHSWTNKAFDFPMADWLLAEWMVLSCEEFLEVDNQAFRRSITHLRPAYSARMVKADAAKNHIHEEYEKVEKRLKEYLKNAPGKKVFAADAWTSNNNLAYLVIVVSFITEEWEMASLLFDFPHLKGQHTGKNMAELLAKKIIDYGLADDFSALAADNASNNDTLCQELASILNEASQRTWYDPEEMTVHCLPHAIHLAVQAFLIELKAVGEDDIDPNQVETPGSAGLGKNPEETAEEVTVQDEGMAEMSDEELLAAQVRDGIDVEVVVQKIHQISKLTRSSPQRWNSTYFMVKRAKELRAAIDELCTRNDLYKKYKISSEEWEVVDVIVEFLEIFRTCSEKMSASNFPTLSASLLVYVKLMNAVDKFMESDIAKKNAILDPCLKHKLFEANPNLFTRDWRHQMETAFKERLTLYSAAAPASTANPSTTPQTPFVSNTNSRSSSINDLFNDESLLGSSAGATETAEEEYARYLGDRTTNNVDCLAFWKMIGKFYPRLAAYARDVLAIPGFLVAVERVLSVGRDLIGLHRHSLSAETSNSTTMITLRKDCLIQRSSVGLPDTIERCGLGFVNHPSEQMASKSDPIRSDRSPNPIPFVICCLIFPAISPALENAASNAVAGEHVTTKNTESTHASKRKPTGDANGNQQHKKKQRSKKTGNESAAEDTAKNTAPELMVDLAMSSSESEVDNKAKLSVTRDIDHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ29</accession>
    <name>A0A8H5CQ29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000122">
        <property type="protein sequence ID" value="KAF5344617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ29"/>
    <dbReference type="OrthoDB" id="3064785at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="509" mass="56405" checksum="99EE013026273AF1" modified="2022-01-19" version="1">MIFFKVSFLCIFLSTDASIAFGYSLFHPFLTSLYSRPSSSYIQRTQESQSGLVAFRPVFLAGTELDAGPRGYLETTRELEFAPNYGHNILGEETTDSRLLSIAMEPHRTQQTREEISLPTSGILHSNTYSSFWLRWRPAEMEYNAHDDDDDDDGNEHSMIGGDDGSQSPSPRHLFHNEKRNKDDDNSNSDSPHPPSSSPTPMSSSSSDTPVIVAAVLGTLLAVLITGLLVYFLRRIWLRKTKINDPEYAFANGAPNQIWSHSKSSSIFPLTERSRQKSKIDDTPTSSATNTLTSQTHSITQPPTLAPTMEEDEASPELDTGLPPSQGASHDPWPESRNFYATPKNAGPPVHRAGRKRKAAGASKVSAASRSTKSTTSSGFSRGSRKRRIRSPGSMITVSDDTTTVTEVSSIRFSPNTERQMEIDEKIQELQSKLSLVHRTIRSGNGGVSREAKTGSVTLANMTHDYRVWKWKRQIEKLKALKESDWAYGKTDVKPAGLYKYDGTSTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQZ7</accession>
    <name>A0A8H5CQZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQZ7"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5346401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="11895" checksum="7D3903D6BC5200B6" modified="2022-01-19" version="1">MSDIEKGSAIASRGVARVGIANPGPLTDHRVVLIHKRVFVFSGLFSFASTTLILSLYNVQARGITTPNVVVGMALFCGGLAQFLAGMWEFPRGNTFGATATVSINPSSSESFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSG6</accession>
    <name>A0A8H5CSG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSG6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5347196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="470" mass="53874" checksum="997856808E025AA3" modified="2022-01-19" version="1">MATFGLREDTGLVGQQYSWLATAFYLTYLFFEFPSNFLLQRWKVLSIYMLCWGVVVLCLGFVQNFTHLVVLRALQGLFECCISPGFILLIGSWYTRGEHVSRALVFQATPGFTTISGLILYGIGTLEYRDQSREAWRYMSYFLGSLTLLVGLLCLYYLGTPSEVSWLTLEQKRMANARILGNQSGHDSTGTEKWKWYQVQECLVDPCFWFAGINSFLNCVPNGGIITFGSLLNVSFGFTPLEVILYQIPQINAAFPYSYHRRRPLQHQMGQPSSLFHGCSNDSAIHRVFGYESDRRRPRYQVDEMGHVLPYGFVSTVFVFGLDSDSFKSGDYMLAIQRYMTIDSECSQGEQNAHSRLHSLLLCIVQETWLARRFLELKMHPNILQESSVAPPALEWNFCLLVFVASTCLCLHLGALEAIMNVRIAWRMIYVLRNRRRDKAQLNDGLTPEEREVQGRLNGEKDLTDFENPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUZ6</accession>
    <name>A0A8H5CUZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUZ6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="229" mass="25403" checksum="955B88521476F888" modified="2022-01-19" version="1">MVRSGLGRETGWSKVHSGVLLTATLISDELAQPPIHPYPPRLRLHTRRYYLFLPILATTPTLIESLSALLISSASPSPSASSHPDASPTHSSMDTDMATALAVAGVRDKGESIDGEDYGTETETEGEGKGRRPRHQCIDIHVDFDVSLHISTHPPPQKKPSKPSFKKTKLYYKTLGSEDAYSPNIHHTCFLINDFSLNNFLPKSALQHKEDPPPHPNNPNDLCKLQRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVR0</accession>
    <name>A0A8H5CVR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVR0"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="16438" checksum="5EBBDF6B546FA906" modified="2022-01-19" version="1">MIFIPSTLRMSATFKSTTCFGMFPFLFSAPLLTPNPSFGRYERSGGHLFNTFEDFLAFSWPVIVVIDAWTRKARIVTRLNYIGAFLKMIKTRFGETLPQAPDILLITPFKSTSRHLRNVSDYTTYRKLYSTLPAAILSALDYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXI5</accession>
    <name>A0A8H5CXI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXI5"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="86"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5349775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="553" mass="59989" checksum="7E61B905928AB220" modified="2022-01-19" version="1">MFSTPLRGFLKPHCSRFKLSNASTTSFCRQGTSSTRPTRFIDSRSMSSASSNTSSSFTPRNAAIVLGLSLTSAMIGYHLAQSSRTTLPSKPKFGTPADFDKAIDELRQAFHDDADIVSTDTDDLRLHGFSENDYHPGSPHTVVVYPRSTEDVVKVVKIATKYRMPIIAYAGATSLEGHFRGHAKSDSDLVCQPGIGWVEINDTLKEKGIPLFFPIDPAPGATIGGMLSTGCSGTNAVRYGTSKGEWFLNATVVLPSGEVIKTRRRSRKSSAGFDVTKLFIGAEGTLGIVTEVTIRLAPVLPTTVAVVHFPNVKKATEAVIEVMSQGVGIQCVELLDDIFMHAINTYGQSSRKWPEMDSLFFKIQGHNKSSLKEYASIIKTIVEKHGGTGFQLAKDDKEAADLWADRKNALYSGLAIGPPGARGWSTDVCVPVSKLPELVYETKKDLASIGLVSTIVGHVGDGNFHSLILFSNDKEWEIARGAVTRMVQRAIQMDGTCTGEHGVGIGKKKFLVEELGPGTVELMRTIKRAVDPLGLFNPGKLYPDEDETKGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CY03</accession>
    <name>A0A8H5CY03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_014623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CY03"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5349434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="367" mass="40882" checksum="69BB4A1F505AFD70" modified="2022-01-19" version="1">MNDSNFSLKRLGLPWYAAAQLLYLLSRTIYIGAAITHFFIWHWGTIYKILKNYWTEECQDPHYRKMKVYKEITNWAYFGIFVVCLALAIGLAYAAKSGLPAWALIIAVIFAWGFTPIIGTLYATVGYAPNIQNLMQMLGGALVPGKPVAKMYFTLYGENPILQALALPGDLKMGQYTKIPPRVTFMLQMIGTIVGGILNFTIMTGTNVWSGQQVQSYNSAAVAWGALGKPLYATGTRYGFVPYMLLVGLGVPIPFWLAHKRWPKVGFNYIFTPVLVAELGLLSVGINSSVFTTFVLSVFSQYYLQKYRATWFRKYNFLMSAALDGGTSVMIFVWTFAVGGAGGKAIPFPNWALNPVGNADYCKRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0F5</accession>
    <name>A0A8H5D0F5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0F5"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="70672" checksum="4845F60E003D417B" modified="2022-01-19" version="1">MVASEIVSRLCDVDFSRKAKAADFLTQTWETFMEAGAGKNQDKVLDVLLAFFCALVARDLVSLTDLAERTTSPSSSVSQSSFVATLFSLLSSLTLSTDPLYLSSNFPTADAQLKKLGIMKSDRAMISTILLITQTLATLPANFLTPNHVPSLLKSFRNLITMLPGLPMANGDTKSTAPLKQQNSVTDTDDIPFAALQHLLNMLDSCLLSQWDSSSSASTSDNQMENELEQTGDEWLADGLLSIGLHSEAACRAGNSDYDIDADRDTDTAEKCIECTFRVLVSLTHANPRWSETLARNPAAVLFIIRTVVRSDSLRNSTLKGLEQMGVDKKEKKAKVEESSVKKIEPSPLFGEDDENGDEDKDEGGEDASPNSKLSKEQALDRLCLALGLLTNLVQAVDDAKRILREIMQVYTHQLSSPSLPNATTSKKQHNDSGIKIKQERSPSPTTTNVSLSRPLPSIAPNAAVDSDSSFLLGHLSVLFGLLMFESPENQELILDALPASSTSAGIKRDEDEDAKPSKSGLNSSSKSKSVSNGRSRMTSRRAKLDDLIDNAKTLARYLAAINQRSLRFGLDHGDGGGDEGGGSSGQDADRNQDQDQAEGSSDSRNGKGNERLDVQREMIKGAEVAQEIIAFLEELRDDCDAGVGNRKAMSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0H4</accession>
    <name>A0A8H5D0H4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0H4"/>
    <dbReference type="OrthoDB" id="3794209at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="24877" checksum="9700C81FFCF4F125" modified="2022-01-19" version="1">MASDIENTEQFSFSMHPVSNIQHESFFPALHSMINASFDVASYIPPSWEPGPEPKTYKRLDTDPSKGALILAEELGEFGFVAVAFVGSNTGMDKMPVAAMGVFPFTGMPRQKITKPGAEWEVTCVAVAPEWRGRGLVMKLVTEIAQHLLREGYLDNQRIRILAMTIEELNGAYWRKIGWQTLEKDGWINIPKSVVINRVPGSYVPISDPVLVWYGERWFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0P4</accession>
    <name>A0A8H5D0P4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0P4"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034986426" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="27666" checksum="7AE5F6672B59F359" modified="2022-01-19" version="1">MYKLASISALAFAGLASAQNVIDVQVGSTADAPGGIFQFIPNNITASKNDIVRFRFSGAPGNHSVTQSSLAKPCDNLANGFDSGWVFIPTAAAANPAPEWNLTITDDTKPLWFYCKQTQPAPHCGAGMVGAINANATVMTTFQNIAKGNTSPGQAVGALVGQGASASAPPGPLNNGASAFGVPAAAAASGSASSPRNPMPVSPTPPLVQVLRLPQPTLAQPLVPLLPNPMVQGRGLILIQPLLPLKPATVATMARRPFTLVDLLLFWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6H0</accession>
    <name>A0A8H5D6H0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6H0"/>
    <dbReference type="OrthoDB" id="3225557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="43041" checksum="982F17EBFB7DE227" modified="2022-01-19" version="1">MIGSQDNRESIVRVFQVIFRYLEAWFPTGPSASKSLTDVTPLAGAKRLIASDWLAIVEMILYYNEVAAHFCDDLTDLDNFIRISKPPTKEIVAFLVRVDNKSRNAGIAARKVLQALDRMERQIIKMQSGLEQQASNMKSPTLFTAPRLNALTSPSSVIHRPSAESHSRMCPREGSTFSDGDILQTLSTRIKIFIPHLQFSWSQVRGYLSQIKGFLRKDDLSSIPSLIQKIFDMIRKLQVFYPVVSQKPTELLWVQKHLVACAHQISKIWRSNEPYYHPAVIDTLKAAFWTDSQNHTCLGKKYINYFGSTIDDDDAKEVPMAMLGLVDVMTVCAFRSRANSALRVSAVTENYVALSRRVFPSAITCNRYISPNTHTESKGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8E7</accession>
    <name>A0A8H5D8E7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8E7"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="922"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5355577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114776" checksum="1CDEA3524598D4A5" modified="2022-01-19" version="1">MSLPPPTYDAHYSPPGLKPYLELPHLLSLTWLAYPILSLIFIAFRLQLSLDSSQDAIASAKDNLLASCKAAEGAATSAASMPRFLATATNAQIADAVNGSMNAARATLILALTIMEAIINFIIDIYRSTLFCFLELVIRGGLAIIIAAVQEFSNVVREAAQGLQTGIQDSINGANSVIKDAIDGINKINPFSDISVPTIPVPDLSSLNNVTLPASFTDALTKLNDTLPTFNEIKDKIEQVIDTPFELLKKDINETFTGINFNSSTLPVPQQNNLAFCNDMDLSVVDDLGQDLVKAAKIGIIIIILLILILIGLNCLLEWYKWRCQKAHLEYTRQAWSTDPTLYQQPKIVAPTPQVTLSDHNLLMLQANGAHPLVTRIVNQISARLRLSPSKHTNLSWFLHYIFHPPALACFLIGFFGILSVQIQLLALGPLIDKYDDRVASTASDFTSTIAASINGSMYNQSSAYANDVNSQILTIQTTINDGMFGWVNDTTTTLNDTLNSFYDEIQGAVSAVFNGTILEQPAQEFLKCFIGSKVEALENALTFLHDNLHVDMPVINETVLVLSPQDVDAASKPIAAAALGSGNGDDNGGLVAKLVNAYADSLRKERVMFAIFLGLWGLVVLMAVGIVFWHSYGKDLVEKRKRRNWEKTQRGGGEGFVTPFRVTPPHSASANEKGLNSHLPDFTPLPSPTRRSPSPKPPSFRVNNISRVGSGPTTEQGEGHGWTGFFGGLTEKKIPKFKPVRKPTGRFPTISYPKRLTSFGRKSSHDDEEDARAPPVPSMANRSVGIDDADDENKRNTAWYSGIFSTMTGRKAPEPSYPALSSSGSDTSSTRRLRPNLRISIERASTLRDQEISAATVPSNDADHATMNSRWSTSPVEQQERIAPWMGVLSPTRRSYTQAQAPSRKDVTSSIPADVNSVYESSQMHIDSTKATTSPSPFSPPLSLAPPLHHGFTGETNNNKRNLAPPPDSHRRSSSVPGLLSASFATPGSAFSNASNMSDSSPMTRYLTSNHARRSSSSLNPFATPFDDEHRVTIQQAPARKSMTTNPFTVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F094</accession>
    <name>A0A8H5F094_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000433">
        <property type="protein sequence ID" value="KAF5319135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F094"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5319135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27763" checksum="EA0D214A840686F2" modified="2022-01-19" version="1">MSVITRNRQIPSITLKTELIGKVTGRKIDADALIDSGAEGIIINGQFTQKNQLTLLPIKNPFPVRNVDGSENTMGWAYHEEQAEFYVMDIGDHNIILGTDWLEEHNPDINWSDSRVDMTRCPETCITAKPPVLHLKTKSLKPTVVDPRTHHKDYQVRWLEPVGQFKPVAQLKIAGRRRQTPIRSFHRSSEVMAIFTEDDDERDTIPERWEQDVMEELLGKEERIDEEAPGTPNLNIRAGFTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8Z2</accession>
    <name>A0A8H5F8Z2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000368">
        <property type="protein sequence ID" value="KAF5328124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F8Z2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="136" mass="15525" checksum="BB5D012CC4ED9AD6" modified="2022-01-19" version="1">MRSGVTLWASLKAQRPTLRHPAVDLEDASLLTFWVRTRSFDLVACGLIGIGAGFVWELLLLLVLVLVSVLEAFRRHIVTGHTEKTLPPTRLFNPSNSDSFRSRSFLRRELASHFRTAQNQAVETLRGFCWHRIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDE6</accession>
    <name>A0A8H5FDE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000307">
        <property type="protein sequence ID" value="KAF5332383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDE6"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="447" mass="49616" checksum="442ED78EFC5E1375" modified="2022-01-19" version="1">MILPLDINMLSLASTMFCKNPYKKLAILSGPLNTVLSVSFSIDGTFVSAAGYGGVMIWDLQTGQVVPTPHLPYSPFEKKHVYSSSAWFYFEESDKHVFICRNMAGQVTVWYWDNLLEQMFQMSESQNVYRNVPEQVLSVDVLQGRVPFDKDGFFVMSTDDNSVAVWKLNSALVLSNVFKTNLPSAFIPRFIQASSSVIAFSKASGSLDSVAFDESRDIFAAWMGKDVVVFKLSSAEHITTFRIEGCDAGKMMQVTFAEDGSMLIAGTGYASAEVFSLDLGKRLQSLSYLGGPLVQCNAALTLPSSHLVAIAGSTKWLPAQVIVFTRRRLVNQYTEIVWVVICLMLPVIYICCLHKLVYYTLDISAYIWTSPHSNAIDAPTTYHSLPATSTVTVTEKDFVTVTKRESVTHIIFEAVPVTFTFKLDSDMTQVTSITHSDVEKVEDLNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEB0</accession>
    <name>A0A8H5FEB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000277">
        <property type="protein sequence ID" value="KAF5333955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEB0"/>
    <dbReference type="OrthoDB" id="2664977at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="260" mass="28959" checksum="AB99B555833B3C17" modified="2022-01-19" version="1">MDYIAMVMMIVNSYLDLYPNLITPTAAPPEIDPMFNGRVIYSYFVTGPDPATIQDIINRGVVNTTHGSFRALPFHPPMPDPFAMTLSGFTYLEVHNFEVWQQVITQLSQNQNFLNFVMTHRDAFAINTPHNVVLTTTLNSTRAHYLVMGQQQGTPRLYWNIYIDPPTLIIPSYLEWITLLRSIQFHTALYGTGTAIARVFDCQRCGSIDHPTGHCPLLNVQGWITTANTNNNQTAQQARGGARGGRGGRGGRGRGRGCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FG18</accession>
    <name>A0A8H5FG18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FG18"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5335232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36364" checksum="5F3AC7FCD1D24ECD" modified="2022-01-19" version="1">MTRPYSTWLLVLLPPLLYIHHRYIFPKFLYPTSKQPRQKLIIPSSERVVILGSSSGIGRVIANKYAKRGAFVCVVGRRKEKVDEVVGECRKLVGGDVDNKIIGFTGDVADVDAMERLRGIIEHTPGWKGLDSLIVAAGVSSVKPLLDITPGVHRVVTAAEAALRGNYIGPLVAATTFIPLLSHTSPCPSIHLISSLASVIPAPTRSLYGSTKSASLVLYQALSIERPDINWSYVLPSTVRGKFREGAVDVWPGERDEDGSTPGPLTVDDAHGGAQEGLTPEQVADTSIHAIDTQHSRPIFIPGYMRLAHWIYWVWPGWVEERARRKYGFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FG20</accession>
    <name>A0A8H5FG20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000245">
        <property type="protein sequence ID" value="KAF5335247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FG20"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="31673" checksum="8781092B0ECAD9E7" modified="2022-01-19" version="1">MNLENPELFIPTKLDLTPLLGGREGSFGVVHKASWHGTEVAVKVLKESEAVLNQKYNQLKNGFLYEVKIWRSIAQHPNVLRFDGCYATVNFTKRDIDLALVSPWAKSGDLRKYKTTFKPWIKTHSILLDVAQGLQHLHTNNPQVVHGDLCRANVLLDIKEKKLMAKLADFGMAKHDGRESSLTVLGMTADLHYERRGPLQKAIRGRSTDNDIFGFGSLIYEIFAGQADFTSQKPIRPSTMNDGKYDKLWLLVEDCWSDEPEKKLNASDLIDRLKELAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHH9</accession>
    <name>A0A8H5FHH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000218">
        <property type="protein sequence ID" value="KAF5337450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHH9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="79" mass="9102" checksum="0FA06D1A1FBFE259" modified="2022-01-19" version="1">MGPCNQLSDPPIPPTCNDWNMSAECAYMCIQPPFNSRCIYIYLWSAVAAKQEVRSSTFVLTDWKRTALFWCLHHMLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI83</accession>
    <name>A0A8H5FI83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI83"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="9">
        <location>
            <begin position="206"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="716"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="777"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="819"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="862"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="905"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="948"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5337527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120044" checksum="99E3A00042FD7A40" modified="2022-01-19" version="1">MSRHSRSTPKDPFQGSRNSPTGLGYSRIVSPNISTTTGSFASQRAQNFATPGFYRKNTKQLISRRADLLARRKINSTSLSRDLSPDRMLVDEAPNEGINLSKRPDNSDERLSLMQSGEVQLPPPSLNFFPHASNFCVGTINNAGRDIVQTTNNYMRTDEGMEMLRVLKEKLNPIAKPARKKDTCLEGTRVKILNDLCNGVTEANTTIVWIYGIAGSGKSAIAVSLAHKIRKIDTKKEVKLALTFHCVKGQETSDICNLVPTLSYHLAQVFPEYGKGLLESLNRDPSLDGTSLSLSAQLELFLDPSLLGKLINKSSEKVVIIIIDGLDEWGSDSDRSELLRHFKALFQFAWLKIVVTSRPNPEIREELMGEFAIRKINLTDYTDTADDLKRLIMSKLPFITNEKVNNMLAKANGLFIWVTTALTFIRKGVDKDGRLEIILDLQTGTKDELQPYEPLYLLYKTVLTESFSQPDNLKYLKAVVGAILASVAYSPDGRHVVSGSSDYTIRIWDIQTGQQVGESLEGHRDGVHSVAFSPDGRHVVSGSNDNTVRIWDVQTGQQFGEPLKGHTKRVWSVAYSPDSRHVVSGSADYTIRIWDIQTGQQVGEPLEGHTDEVNSVAFSPDSRHVGSGSDDNTVRIWDMQTRQQVGEPLKGHTEMVWSVAFSPDGRHGVSGSDDETIKIWDIQTCQQVGEPLKGHTKIVRIWDIQTFQQFEEPQQLSNHTDAIRSVAFSPDGRHVVSVSDDHTIRIWDMQTCQQVGKPLKGHTDWDMQTCQQVGKPLEGHKSFVLSVAFSSDGRHVVSGSADGTIRIWDMQTCKVGKPLEGHPDWVRSVAFSPDGRHVVSGSEDRTIRIWDMQTCQQVGEPLEGHTDWVTSVAFSPDGRHVVSGSNDRTIRIWDMQTCQQVGEPLEGHTDWVRSVAFSPDGRHVVSGSDDRTIRIWDMQTCQQVGEPLEGHTNWVWSVAFSPDGRHVVSGSWDKTVRIWNIDPSNPNLIPASISQYNKKNQSCSINPQGWLCTAEPEPKLILWIPPHLRFGFNDLRRVGTIPADAKNSGVKADWSKFVCGENWTSVWNDNPEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIQ7</accession>
    <name>A0A8H5FIQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000197">
        <property type="protein sequence ID" value="KAF5338291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIQ7"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="43146" checksum="E84D2C9901D965C2" modified="2022-01-19" version="1">MSTHSRLVGLGDDYNAIFPFSTLSDKELSPFWPDRGYSSHRSIYQSSQTSFKNPTSPALMARTDVCPLRFIDVSTLRLVEFSKEEIIPPYAILSHRWTEEEVVYKEFLNPEESRTKMGYQKILGACRQALQDDIHLIWVDTCCINQGDPADIAANITSMYAYYQNAEVCYVYLNDVIKRRDICYGRNEFGQMGSDWLKRGWTMQELIAPRTVIFFNQHWMYLGDKHQLREGVSAITYIPLSILSGEQSLQDIDDLTRMSWATNRVTTKPQDKAYCLQGLFGVTLVPDYEEDMARSFNRLGEVLCDAHPELIERLGIPQNFFDNPGEYEKSFYDFAWDKSAEIWYEMYAESRNRGHIKGFDNYDEGSLLSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLV5</accession>
    <name>A0A8H5FLV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLV5"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5341546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="62884" checksum="4D3CEE4550C1EA3D" modified="2022-01-19" version="1">MKAFSASEVAQHNKRGDLWVIIDSEVYDLSKFSDLHPGGPTVLLDADIGELGLGMYDYVRANYGQYVAGQDATEAFFSLHLSEILSLPQYTRLKVGVVQGHEDRLEQDSIPLNAISKIPYAEPSWLTNLPSPYYKPHHFEFLQAYRSFIRGVVLPDARAREEDGKPPSQHVLKEMARLNIPAMRLGRGEHLKGRKLMDGVITEDQVDHFIKLIMIQESSHLHSRGYSDGLGGGAVIALPPIIAYASAKLKDLIVPQVLDGKKSVCLAITEAFAGSDIQGPGPNRKGSGGIRTTAKKVAGGYRVTGTKKWITNAMWADWFVTACRVEDAREGDGDIIALIISRGEGITTRPLKTSYSSGAAGTAFIVFDDVFVPEGNLLRFRDPSGNGKETPVRRGDGLRILLGNFNHERWVLAAETVSIQRAITSQCFKWVSLRHTFGRPLSSQPVVRGKLANMAARVETGQGWLEQIAYWMDCINNGESNSNSKVKAKAEDLASPISLLKMHVTRDAQATAADAAQIFGGRSFTRTGMGRDVEHFHRTLLIDAIGGGAEDILADLGIRQALRRMPKGREARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN00</accession>
    <name>A0A8H5FN00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7alpha-cephem-methoxylase P8 chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN00"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33695" checksum="C13D0A0BC232B211" modified="2022-01-19" version="1">MATSIEKSSPYTLSTNTMPATLIQPSFVSASLHFFSPPSDGSSPFVDISVPELKRNYEEKTHVVQIENLRGNESSVSLDTAGFQFYNEPAKHKSFKNDEEIKREYYPESIELIKKLTGASRVVLFDHTTRRRRPGVSGADPSNRQPAAMVHGDQTARAARNRVLRHLPESESGELLKHRYQIINLWRPISHPAYDWPLALADYRSVDAEKGLTPVAFFHPGREENRETMGVSYNPALKFKYLRGMTPDEIVLIKCYDSKDDGSVSIMTPHTAFEDPTTPADALFRESIELRALVFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN82</accession>
    <name>A0A8H5FN82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000158">
        <property type="protein sequence ID" value="KAF5342747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN82"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5342747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="24075" checksum="D5FEEEC912F079D6" modified="2022-01-19" version="1">MWASTNHDQRTFSYLHSLHLLVRINRFPLYFLNIVMDHDPTSLSQPTVHKSKFRPSTDALRNAARAHNLALRPNPTKQRKEKEKQPIKVIELSDDELPSSRTKKPRNCYEQMAAELQEMLRKALEKQTKLEEENAQLKNELSTYQAMIYLNADDVKGYIVCDVCASTMWSPFILTGCGHTFCDECLDNWFKEILKKWKERNPTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNJ5</accession>
    <name>A0A8H5FNJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNJ5"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="770" mass="87937" checksum="0A3AB232B20FB943" modified="2022-01-19" version="1">MPHLPFGGMNMIFAGDFGQLPPAIGGESVALYSHSIGQSPKSRSDQENAIGQHLWHQVTTVVMLRKNMRQTETSENDDNYRKALENMRYRSCTSKDIAFLRTLISNPYEPARSLRNENFRNTPIILTYNKHKDVANKLGTERFAAETGQTLMSFYSEDEQVVLEDIPENEKQHRKRRKSKRFKVNNKVQHELWTQPHSYNDRQIPGRLDICLGMPVMIRYNSATELCITKGQEGHVHGWKAKIGKHGKPVLDVLFIKLHNPPKPPSPIQFEGLPENVVPIVRNTVRIECKLPDDSQIAISRTQVEVLPNFAMTDFASQGKTRDWNVVDINNSRDFRAIYTALSRSSCADQTLILQGFNGSLLTGGLKNKGGYRQELRELEILDELSKLKHLGLLPPSVSGDRRSVLIKSFRTLKGQNFVPAFAHKSILWNDNDPLAETFDSRETWHIIDDKEDQQKKSTQPKGDFKPALGAATNVPSTSSLKRKSSSEKINQDVPLKRHKADSNTSTEFTPLLPFLSWSNNSCAYDSAIMLLHYLHSNYPEKFQTEASHFIQILSTELTSAFQSNVVDLARTRESLRLGLHHIDSNAFPYGEYADAGKVLLELTQSDMPFSKRRVVCNNEHVFKPWKDRKNMVLYTSTQAYHSTQEWLDNYIQPFGWKCQTCHTDLQTIVEFIRFPEFFLLYIPINVSTQIDKFVNLTVNQQQRPYHLRAVIYFGDGHFILRTFNDEGDYIYDGMKNGLPQKVGTPIGENDTIADYEGKKAATLLYIKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNP0</accession>
    <name>A0A8H5FNP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNP0"/>
    <dbReference type="OrthoDB" id="3037214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="109" mass="11901" checksum="21077F6D130AA333" modified="2022-01-19" version="1">MTALIKRNNTVPTKKSDIFSTYTDNQPALTIQVFEGERARTKDNNLLGKFDLQGIPPAPGTRKNIATTSLVPPIQARHYTTPRSQAFGDEEDKLTGDAPGPNTFADGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQA0</accession>
    <name>A0A8H5FQA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQA0"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="54"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="938" mass="104366" checksum="216B04558A443DEA" modified="2022-01-19" version="1">MSLLSFIMKNINDKRFASFCQRSLLAPPQKEASAYKSSKSVQDMSKTHTAIATTSIGNFDVIQVPTGKAGDGQVLLKHEYAAMIPFDTYVNDFGYITPKFHMIFGFSAAGTIVEVGSGVDDLKVGDRVTAFTYGESQFKGAQEYSVQPRHIPDSLSLEEACTIPDNFITAFGSLFNPIYLALPIPSSFPAPTAPPLAHTPILVLWRWFELRTLLNAAGYDNVIVTASSKHHEYLRSLGAKHTLDYRSPNLAKEVGDIVTSSKGKSDGKIDLVLDCISTETTLGAIGKFISPLGKLAILLPVKEGDNVRGDEKMYIDPSQFPEKMQDLIPKETTLYGVRTFLYAENEYLRTKLMPRILPELLETGIIKPNKIRLIDESSGSLKDRVGTGLDLLRNNQISGEKVVVKVGDITAAIFLYQTKESRTVACHWSRFKLQGMLILWRNKQQLNCKTCGLGNFLTFFSFDMLSTNGIECWIGKRSDPSPSAEIPHAVPKTRLEDDVTVIEATIKLKSSTAGVALDWQELNWRKAGDADPQSYWCVVRWTSGAGKEKIIHKTWMSRSHMETQTRSTRDLQQAHNHQRSFPVIKALKSTNHLGVIRLELQRIKGDIRFKRKSSKDVIDIVLEDEKPFLVFEFRFEMLNSDSEGPKKSKKSQRKIQSQQQITKSDRTPSPSRRHKLQVSQPSPKQSKQLEPQALTAESQSKNPLNLDLNDADADGDPDDMIMDSGVDRSASEVPAAGLSISHSPLSNMHPSSADPSHDGPDELGTDSLATNANSKAIDLRFQTLLRATASMNGPSSTELAIDRVAQAEIEEHFAYPNAVISPSESLALVSMHDSGSQVPVQKRTFSQAISLLTQAGVHAGDRADLKMMVADLNPHVRELQEVELLLRQKQREQLRLDAELIELTKACTASLKEQVDTLEGQNERKRKWLQFVKDQTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX22</accession>
    <name>A0A8H5FX22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX22"/>
    <dbReference type="OrthoDB" id="4791183at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034485095" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="184" mass="20634" checksum="8C030433EC419129" modified="2022-01-19" version="1">MLLSTQGLLFLSSVILSYAQTATSAHASFSVHYPWATRRPANDIRSTLEDFKPFCGIPIRNPQRFAAYQTTFFSFSGHPGDLVTVRYGRTRVARNRDAFPITIASNVPISPTGQLCFDVQMPIPLKENEHGMFLFEAIDPGTSKIADYHCLDVYMVDNDDAKSEDHPAMCARNNDSLIPMPDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FY00</accession>
    <name>A0A8H5FY00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FY00"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="4">
        <location>
            <begin position="46"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="551" mass="60597" checksum="3B611780BC27692C" modified="2022-01-19" version="1">MPQKVELTDSLKRAIGKRFVLGYHGTSPKLDDPESEGIKTLLEAPYYLGNVILMKRNVKGKDEVREMIRYLQKHASEAQGEEAKPLLIGTDQEGGLVSAFTVPPGRGQEAVTQFPGAMPLGRIKDDVKYEISALEMTRKTYEASGKELAMLGVNWVYAPVGDVNTDKKNPVIGVRSFGEGPEEVAKHVEKACEGLRSAGIAPCVKHFPGHGDCSVDSHLGMPVIKKGMDELAKGELVPFERVSSWEGVTMMTGHMAMPEVTGKMYEPCSLSREVTTRLLREKMGFKGLVVTDCLEMDAIARTQASEKEKEGGWGGGCGIEEGAVRAIEAGADVVMICHTFRKQVGAIEKVWQAVEDGRITVDELMTGAERVDKLKDWLGLTWTNVMNEDEDWQSRWSQLKIENAAVAKEGYKRSILVKDGFTRMDKNIPTTLYTPANESINLAVDDAEGVLRTKDGKIRNTAGASFLAMAEALPWCKHVVYRDEVEVQEGQAIFVFRNGDTAKWQQDALARVKAKSSRVVIVSTGTPYEEEYDLASCESSAVALTELATRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1I7</accession>
    <name>A0A8H5G1I7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1I7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5356608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="545" mass="61230" checksum="ED3E396ADF536E48" modified="2022-01-19" version="1">MSESGIPRTTRSRTASQNPSRTSSPHIVCLRRPHTHVPRNQQDCYFSHQNRWEFCTNHPCPNRLSVHNRPLSIEEQTIGIEPVSLFKSLPSEPTTESPNPVTTPSPTPSHEPSPESQPSHNRSPTNSTPSAAQEPLSVNPSFPIDFHSIHAALRMSENPASATAAAGGTQAPRDAPPPDDDVQDAQSSVFPNLTTKERGVKPEKFTGDRNQTKDWMAEFNNYLRLNEQVYPTEEEKISFFLTLFSGEEAKRWAHNMMVKVFEEEDDFSDSDEEYTSTDEGSSALKPKAKGKSWTLREVKREFLRDFKPSARETQAQTKIEHIKMEGALANIDKYNSQFKRYADDTGYNDKALMKWYRKGLPRGLVDRISYLSTQPRNLAALQKAAVKQHMIWLERQEEKNSWSKPRREEGQPGRGSQGARGGRARSLEVNALQDNVPGASSTTKYPLKLTPQEREKMRKEGRCFRCRGLGHMGNDCPTFPNTPSVTPNNTTWRPSIKKTAVTTEASESKADTTADNISELTARIGALSGEEKEGLLKKFVTEADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Q6</accession>
    <name>A0A8H5G5Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Q6"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="37578" checksum="7C7D36A82E9FB800" modified="2022-01-19" version="1">MAPRTKILLTGATGYIGGSILNRFLARPDFQSSFDIRVLVRSPEKAPKFDALGFKSIVGSHTDEEVMIQAVSEVDIVVGVTDCDSIPAAELTIKGLKKHFEETGKQAFFIQTSGAGVYLQLTDKMSETDVIYDDANPDQIETLAPTQPHRNVDLKILDAEKEGFFKSCIVLPTLVYGVATGPLFDSGLSNSHSLLIPLISRAALERRRAGMIGQGKNVCPIVEIHEVADFYIILIEKCIKSPDAVPHGREGIYNLENGNCTYYDLAEAIGKALVALGRGDNSTPLTFTPEEEKKYFGAYAPLFGADCRCIATRARSFGWDPKMTTADLLGGVQKEIEILIKTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7W9</accession>
    <name>A0A8H5G7W9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7W9"/>
    <dbReference type="OrthoDB" id="3069822at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="845"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1222" mass="138362" checksum="0E992854A9102DEC" modified="2022-01-19" version="1">MSSNNAINNAESIFNVPILNTTNYEFWNYAITRLLEAKGLSRVASGTQKRYVNTSPTETGNAPSLPEGFVLVTNEVFNALTESEQSSYNQIVDTLAHEWDQYQILVNKHDRELVETYKLHSSWDDKDEQALGFISSYLPNDVGLEMREFTKEEVEEDPCAKAKGDYTAKMLWDKIDKKYSSPGPTSWFLDFKEFMSWTLDEKKDPANQIASLGAVLTRLKAYGFTVDDKFRALFLMDRIPQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKRRTGQSSESSLLTCITGDRRKFDSAPNWNNQKAGSSKQKNQDKGKGKQPKPQEPSKTVTTGDANQGGDKKKKTRHSKKKKGSKKGAANLANPEVEADSDSDDDAPLMVTAFMANPFINATLDPIEISDTDDLPETCEQPIYELLPYHNFLIVRSDCFIDENNDSSLKERVKRNLAKQVRPQTISGYFILTHYERLMINELAQETVDFESFLRVEARHQMTRKQAEIWDYTYNSDGTHTEPYLRAKNNLNGDEDMTNQWFDHEGTIRPIQKQIEEEVEYFCRYIMNKALTDMRNHKWIPQQFKKREPVPSKPPSLIERAYWPTPAQSVMRTNDVTINTQFHDTSLYPDFIRTLPFNHTKASSSSSSRKRKAVRGSSSSESSDSTSSNHSEESSFKYIPPSIAFKMWQDRMSHMFTDPILENMKREPDESGNTSKKPRYDAPLEEEAGPSSLADAINVSISSGYLADDDGVSLGSESDVEIYIDGDETMAFWQVFHTSNKNSALIQLPQISMSLDYCESHTALAAIDNCTIITNDVPVFIYEQSFVARAHCSTCEKYPLNSICKSKITDEITYWVSDSGASTHITNNLMDFAQYHKLPNPIPLQIADKRSETYLEGIGTVFIEHINEEGVKHTIKLYPVFYQPTCTHRLLSRGCILREGYYEISRDGNPQALFIEKWFPRVLSSETEESDKSTKPVQPSELMRSLHKQGTNNLPPDPVVPLDLDDLFRDQFDDQGPPPDEGNGDHQDIDDGNGSDASSEDHDPGAHQPSDPNDSETESTQSREPTPPPAPEPPAQVDPVPVQGPQPVNPRNVDLTTGRFINRVPNPNQTRSSDRQSRPNWRITDPNMQHSRDIPRGGWTRVTPRVTRSQSRATGSQTVTDPTPSTSQVREESDNEDKSETEAGPSGEIAEFLEQDVLEQRVQQGGWMNIHITMIPIEIQIQKIKEIKLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8D3</accession>
    <name>A0A8H5G8D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8D3"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="450"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5360252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="514" mass="58616" checksum="B1649C0679C578DB" modified="2022-01-19" version="1">MPYANPACDDFIPDCSQLHELYAPPEYHQFRLPIPSPSSVDPSDPSPDMKFVLSALGPIAFNVSVRRPGQSQRYRLALLLGYERHWSRVWNWTSFLVNHFVLGDDPETEEGLSFRDALLDVFPKLLALYFVDGSGFDVTYTRSFMQKRSDVFPLIIQVLSYALHFSHPSLHPMLTLPLDVALAASGEKPLRLRNATFLIRSPDTVNLLFSYISTEIQKSAESDSSYLQNALRTIWFLTETKPERKFLSVLILSRDAIGCLASWCRTLVLPSRLPVTAFESECCIVEDSLDSLKHVLHVLCLSTSMEHHRYPAMALLLRGGIIQSWIYAGRLISYDETRLAPPQDEYFGRTVGRMFFELLGDLPSMLGCHKIFGLVSRSLRACLVGESQKNQTRREALEFFLKDNVSCSPNLTHKALGELWERLVAQVAKVEMERRTFEQQGLVVCGYPKCPHRGTYIGSKIYRMRCARCKTTVYCSQSCQKRDWKNGNHRVKCNSAYDVEISLTEHRYLVSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8Q4</accession>
    <name>A0A8H5G8Q4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8Q4"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="751"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5360301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="912" mass="99719" checksum="FF65899F221FD077" modified="2022-01-19" version="1">MPPVTSSDQPEQPSSPSASSSILKERRFKLSRACDRCRRRRIKCDEGHPCQACLSANSACTFEEPGKRTHPHKSKRTATLEDRMHHLETLIQAIPPAVFAAGAGNPALSALKTIHSDQSTSPINAPFMFPTFPSGVPPPSLHVFPLTNPSTHFAPEIKQDEPQKSPTSAFQTLMGGLYDTKPQVNPEQLAEETANMSLSASYLYFDDEGYTRWQGETSGLPLLDLLIERQVPSGDAEVTPNSDGVSQNASSDNSWFPNRSLKRMTSINPQHLWRMITAYISPDLMDSLVQCYLSTSYYILPFLHVPTFLSDYGSPQKWGEPGFATFIVAICCLASRHMDDPRVRAVPTEGITAGTQWFELLGRLRTLPIADRPTLYTIQADLIAAVYAVGLGRLSRAAALLSEAITVSIDAGLHRSADTYDLFDPIEDEIRKRTFWCVYIWDKQLSAHFGRPPIIRLRDCDVAEPLPLDDEFITRDGVQVPPPGTECRMSAFVYSLRIMIVLESVLDVPLPRQEKNGFGSTSFIARAARMVTGINGFKELREAEGLLDEISRTMPAFWKHTPETLAADDTIRMTQAGRLHCAEHFVRMLIYRHRFSQKVAERMNSGGDEEQRQTQTEGEREAMIAAHNSALQIIVTHVHIAGKGLMTYYGVHVIHQLTQAGRTVVAILLNCKSEAMQPLITPGLDALRSCVGLLRRFSGRYVCGLRSGDLLEEFCRRVPSVLSPHFGVTFFVTQIPLELVRQDNLQNNSRPAWIRPVRKKVSSQSNANGRRGSQSGESPSGNSHQDHSSPEAFSPSDFFVEPKASTSTPGPGSVSPTAGPGPSQNPDSTTFGGINGLGMSPSSHGLGSLGQGPGLGGMDGMEIDQGSGMYIPSVDMVSLFGEQGIDVSQIFAGDFEVGGPGERGPGGLGTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAM3</accession>
    <name>A0A8H5GAM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAM3"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034525128" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="579" mass="64083" checksum="2FC1795615E2F998" modified="2022-01-19" version="1">MVARISLIAAFATLVVGELQRSCRILPTDPSWPNSEVWEAFNQSIDGRLIKTVPIGSPCHDPTYDEAECNLIRENWHIPDFHEPNPSSVMDPTFLNKSCDPFDPRETPCRIGAYVQYAVNVSSPEHVIKTVKFVKEHNIRFVVKNTGHDYLGRSTATGAVSVWLHNLQNITFLPQYTSSGYSGPAFKVHTGVTGYDLEMEAHSRGLAIVGGECPTVAFAGGYLQGGGHSALTSFYGLAADQTLEFEVITTQGKFVRASPTSNEDLYWALSGGGGGYGVVWSATVKAQQDLPATVASLNFTIEGIDQETFWKAIDAYQASTPTLTDAKIFSIAVYTNQTFSLNPVFAVDKSASEVSTLLQPLTNTLDDLGVEYGIAVNTYDGYLDAYNTITFLREFKVGDNIFGSRLLPRLIWEDKDKLKELQDTITQILEDGAIVQDFSLRATGPGNSDNAVLPAWRDAERHFAVILPTIDGDSLEDVARDRNRITNRFMPALKQLTPGSGSYVNEADPYEPDFKEAFYGSNYDRLLEIKDKWDPKQVLYGSLSVGGDRWKQTEEGRLCRTEDVHAVPYLVDPTSYHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDF0</accession>
    <name>A0A8H5GDF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDF0"/>
    <dbReference type="OrthoDB" id="2977013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="2">
        <location>
            <begin position="116"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="445" mass="49663" checksum="3A25682301032123" modified="2022-01-19" version="1">MRPRPDRQTSLHNQRPRLDSDKPFQQANKANYNGKKDSQFGLNGTSSTLSSKHSATVLYATPSASDQSCPLRRAMELSGVLAEIPSYVDEPISSPHSLLSFNRKAVPSMPPQPSESGLTTLLNSPIPPIVNPFSNLMSPPPSGDDLMAVRVYCPHADNPVGKPLEFKIEREADVERLMGLALWTYWERAWLPPLPVNHTEDLRLPTTRKSHSIKASNGKLRRVISPWSLRIVRDGFLDYATEAPDPSDKVELLESEEYALIKLDRTAPDPAGFFSGIPSVDTSSNALGPNSQASTLAESFKTSQRRTSRRNSSPGPLSIRKRLSHVRDLSLPFQRASMDSSSRWPSDFVSNPFRVRVFKILNAEMDVKEGSNEQAQPMTVAVSKNSTIKELLQTVCREKGIRHPEKFHLAALDVRKVYQGVDLQWNVSKFEANTEFVLVKNAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDH2</accession>
    <name>A0A8H5GDH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDH2"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5362898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="268" mass="29182" checksum="13691113E077765F" modified="2022-01-19" version="1">MRPTPSRLLNILVPVKRAVDYAVKIRVNSSQTGVDLNVKHSMNPFDEIAVEEAVRLREKHKSDIKSIKAFTIGPPKSVETLRTALAMGADSAVHVELPESAPSPEPLSVAKAIRSYIGKQESEGGVDVVILGKQSIDDDLGQTGQMLAGLLGWGQATYASKVELDLGKKEALVTREIDGGHEEVRVKLPMVVTTDLRLNEPRYASLPNIMKAKKKPVEKLKPEDLGVDFTPIIETLKVSEPPKRVGGGKVESVDELVEKLKEHGFTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE19</accession>
    <name>A0A8H5GE19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE19"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="278" mass="30952" checksum="030CB8878A432508" modified="2022-01-19" version="1">MGPPTSPLARYNTDNHNATLTNCVSANIHHFGSLPSLHLANLPPFLVISILRTTWLLGLQWTQMHIGLDTDSDSESDSDYLTDSSSLSSSSTSTSLTSFTSFSSFSSPNTSPFTSPKLSSSVDSPVRPIARGLSLGVDVHASASGPSTASELPFPLPRPFPLHPYLNCLYRNLQPNKPKDKNSRPLPHHLPTLLGPPKRQRSLTTSIGQIHFDKRMLFNDGFWNKHKRCREIRRIFQREQLDLLREREGNADQGEGDDDHRAGNRDRGAWDAFLRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGL9</accession>
    <name>A0A8H5GGL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGL9"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="277"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5364699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="463" mass="50078" checksum="531CA7B8869AADE4" modified="2022-01-19" version="1">MEAENFKTATTDENGSRFSEKEEREAKNGTPNPNTSVETRSDEKSDNEKSVEQSPESKLVPGESETDFPDGGLRAWLVVLGTALSSTASFGYINAWGVFQSYYEQTLLEQYSASTIAWIGSVQYMMVFLPAVVSGRLFDIGWFKVPYFAASCLLVVATILVGQCTQFWHFLLCQGFAIGLATGMIYGPTMGVIGHWFKRKRGMAMGLTAVGSSAGGTVFPIAARKLIPLVGFPWTMRILGFMLLFVLVIANLSLARRLPPKNLKGGLFNPKAFKDIPYAVYTVASVLVFFGLYTVLTYIDISAVHVGVSDDFSFYLVSLANASSALGRILAGIMVDRIGAVNYVAPMTFFAGILTYAWPFAKSEGSLIAVAIIYGIMNGTFVSSFLFPVFELGELGDVGRRTGMVLSLSAIGTLFGIPISGAISSATGGFEAVGFWAGSVIIVAVMLMLVTRHLVLKKLWGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHC8</accession>
    <name>A0A8H5GHC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHC8"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5364810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="26768" checksum="949BFAC1380AED77" modified="2022-01-19" version="1">MSSVLSKLNIAHASYIVAAVTLGLSLLGNLFALVYQSDIIFGLTAHKYTYIEGDHPRHLPLTVGPANMVFKSNLGHFGLGNDPVTWAEWSTMRPREAGYVYLGQTHLPIDVSMWHQVHCLSHIRSLISKGDDGSEHTEHCFHYLRQGILCNADPTLEPRSRQSFDLNGKEIFPGDEVTHTCKDFQYIYEWTMKHREGWSQEEVDRFLSVGQMKHHGGGNGTMEHGGMHGGMHGGGMHGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHN2</accession>
    <name>A0A8H5GHN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHN2"/>
    <dbReference type="OrthoDB" id="3263038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="753"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5364945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="939" mass="103621" checksum="8F1EA5EA8A787966" modified="2022-01-19" version="1">MSHPTNSPPRRRSPTVGQGVFAGLGNIFSYPSPNPNVSHPPTPFVTSPSPNGNGDEDLYSSIPRTASGNLSGGATPRQSAPPPGYPTQPPSQVGSPTATPQHQPIPQPIPQPIPQPVPQPPMPMQPPIPPPNPNRLVGVHPWNVVIQHAHPLNGFVPPRVPDQTFGIGQKADFWSSVPMLKGETNFTEFRQRVEIAATASGMASVLDPQYANYHPMEPLPNDPDYEANMHTFRTYQMLEHQTRTLLVGKLPSDIMRWALHGSHMCLDIWMHLISRYQMANALDTAGLIKIWMNRSCTNDSKVNFRKWLEEDEDIIRCIGDAGGIISDQEKKNHVLTSIPLMYKTYIGQMNDTMKINSNGTHKLSTQEIIDLLRSHYLFLHPELPSWSTSSTEKSLSSSKTSDPAKDLKNVTLQASSTLGSTSNTPTANKVNISMGIQCYNCKGFGHLSRDCPTPKQKPNGGGNGGRGKNWRGRGRGRGGGNPGGYGGANANNGGNTANVEGTPKPGNTTTPSVVLNSNPKPNTYLKPAGQAGMAENISFAYIAQPSSDISEDDWSDDEYEEEILVPLSPKFLNRPVSQITDVTDEEIGPLTTDELDHIESTIKQLGNQLPDEKRKVLWQLNATLVARHASQWLYEKFAYEVWEDEEDEENDSESDSEDDFTMESGDKDESKEVPDVQGGNDIYMCVTDLTFILNNGISVDKSSKPVVMQTDSMEPTASVFASKGHRVYWKDTRTVTVEHLLVFTVVDIFEGTGDEGEREELRELSEDESIDESTIEELSIEGPKYQDLHPDNDDILDLSQLDEPGLDSDTQPEPLNHPHRTPKPSRYVQDLQKGVGTTTGTGRTRTILPCGIADAVAEEQEGIAMEAHLENRIIVIVASVDDLTILTSSIELIDYVKSKLHERFTITDMGELHWILGIQVIRDRKMVQLLFLNMLISSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL51</accession>
    <name>A0A8H5GL51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL51"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034970132" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="62328" checksum="29086268D57FD7AA" modified="2022-01-19" version="1">MFSRKRSSFIPVPLLLPVLAASLSMSCTTYSSTLVAGHLTSSSGYPVADFDSKCSSIASQLNSSIPNATVRFAELVTQGTNITFTDSDRDPSCIAQPFFLPASLIVRADICRISLDVQTSERSGIHMETWLPRNWTGRFLSTGNGGLGGCIQFADMAYTSSLGFATVGANNGHDGFSGRPFLNNSDVLEDFAYRSVHTGVVLGKEITKTFYGHEHTKSYFLGCSTGGRQGLKSIQDFPEDFDGVVAGAPANQVKLMDDFSYIFSLTGTPDASSFVPKEAWVNIVHPDLLKQCDKVIDGVEDGIIEDPHLCNYDPSGIVCSGDSNATSCITPEQADTVRKVFSPFFIGDEFIFPRLVPGSETGDGLRSVLAGDVAPFSVDWFKFVVNSDPNLDAKTLGPSDWKKCIAQDPFNISTFKGDISAFKNRGGKLLSYHGQVDSLISPESSEIYYDHVSSTMDLSTSQMDDFYRHFRISGMFHCFTGPGAWNVGQGLLGDTSPGSDYTDPEKNILMATVRWVEEGTAPETIEGTKFVNDTNSLGVEFSRKHCRFPLRNTYDGVGDSTKPESWSCQPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLF9</accession>
    <name>A0A8H5GLF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLF9"/>
    <dbReference type="OrthoDB" id="3355886at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="132" mass="13966" checksum="B43EB23118860700" modified="2022-01-19" version="1">MRPSFPTSYSTGLNGSQCGVIAFQITFAHSIMFRLTSARALSKAVKPASTRSFHSPFAVLGSASPSPSNVKPSTVYEKASEASEEFSQPAVGLRTHVISPNPTTMFKQVPTGAYPVSVSYAESSTTNQVSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN58</accession>
    <name>A0A8H5GN58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN58"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="472" mass="51881" checksum="031F9BE6FB6C8419" modified="2022-01-19" version="1">MSTIVNGSAQPNPPGYPHPNPCISFWLQGTRSSQLIGHRTTDKLPETADVVIIGSGISGAAVAYFLLTGPNPPEKVVMLEAREACHGATGRNGGHCRPDCYRGYKGYKNHFGKEQALKILRNEMDTLNLVTEVIDKEGIDCDFWRGRSFDIAMDKECREFFHTSLQEFIADGGPTEGIVEWIGDQEEARKRTRTSKAVAAAEFPAASLWPYKLVKHLLLLCIGKHGLNLQTNTPARSVSQTEGGWSIHTDRGDIKTEKVVYASNAFTPTLLPEFLGRIAPYRGQCSAIIPTKPFSGKNIMTHTFSHRWGLNDFDYTIQRPKDGIIIHGGGRWKVPIELLVGHTDDSEKLPVLTEHLNGFMKENLEGWGEEALGEGLLVDWTGIMGYTPEAVPYVGAVHGKPGAFITAGHSGHGMARTMTCSRGIAALLRGESYESTGLPECFQPTPERLNSSKITVEQLWCEADKTGIPLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ20</accession>
    <name>A0A8H5GQ20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ20"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="82419" checksum="0213CD6FF9064676" modified="2022-01-19" version="1">MEYCHSCHLSSTSIVQNSQSRRRAETPQRTILDDELETYGERPIEEKSVLAWALLDAVLDVESRDMQFPDIKPSNVLLASEGLKLIDLDSKRHTRQYWGDPVSAAVKVHTRLLASTLLHPFKRLRDFSLRSRNWEEHLEQPDSKSALRDVLIPEPFAKGIKVAWDWSVPSVHALYDTLIRDHRSTGHHSLCVSEKSTQAFPSTNDDSLLSSPPNSLQPQLAELDLRRKQTCRGYTLGGRVDPRLRLIGAEIVIPVGVCQVADCNWFPYLARMPPGNRRSPSSITPDMPFLDTHPECDSSQSHVLKNGPLVLVALIYEGLGVVFAFLVKQFFWVPHRFRYGILVAGGWGNVGDIPTSVVMSLTASAPFNPKTDQNLAVAYISVFILVYMLTLFPLGTHRLIAKDFVGPDVEHEEVREKVRERRRLLLYYWPKALAQLRHRKSKSQDSDDPENQGSSVTVEKHTDSGNVEVMSENNTLRARATKYVSIVAEGQNHDGAPSEGIVSPTPTERITSPTATIIDNQLISERPAIKSDRSDEPVSRTSIAEKHPRLQKVCAELKDAIKSTLTPASLSILLSFPIALVPQLKGLFTETSGSGIPNAPDGQPPLAFILDFTSFMGAASVPMALIGLGSALARIQVPRDQWKDLPLGAIFSLAIVKLIVTPVLGVLITHGLVNGGVIDEDDKIIQFISMFFSCLPTATTQVFITQVYSGTGSAEFMSPFLPLQYFLMLLSMTALTAYSLNTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQM2</accession>
    <name>A0A8H5GQM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQM2"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5369267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="310" mass="34611" checksum="2AC64CCD63EE9480" modified="2022-01-19" version="1">MDNYRLCATVTEHDAKKAGAEVVKQVESPLLSGLLYPGLQALDEQYLGVDFQFGGIDQRKIFTFAELYLPRLGYKKRAHLMNAMVPGLAGGKMSSSDPNSKIDFLDGPDVIKRKVKAAFCEEGNVDENGLLAFTGAVLFPLSQLKIDQSKGLEGLGISADPKPFASENAPEGTVFTVDRGEKYGGPLHYTKFDDMKNDFASKAIHPGDLKKTVTAALTRLLAPIQKAFQEDEDWKAIEKLAYPDPNAKPEKKKKEKVYHPPPPGKGKNARLPRKLPTQLRRLQQDPHKETQKRRMHEMEKKHVSDRIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQR2</accession>
    <name>A0A8H5GQR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQR2"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5369327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="284" mass="30564" checksum="A65D8E9386545E75" modified="2022-01-19" version="1">MSSSPSPAHATPTPERDPQLLSIGKQCSHPSCLLIDFLPFKCQHCEDSFCQEHFMVNAHSCPKYDASKHNRVAPNCPLCNEPVAIRVGQEPNARMEEHFAKECSVMLGKTVKKSTPTCARAKCGKVLFSPIRCDKCQKQFCPTHRFPSDHSCNSTPAASTSSQQHRPGGIPASSRLLNLNAKTIETKASAAGTAIKKSLTTASTSASASTLKSSTSTSSSHLNLFSKTDRNLLPEITISSNDETPKLTTSSTTTVSPKSPPKSPKLAFAVRPNPFVPRPVFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQV1</accession>
    <name>A0A8H5GQV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_002503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQV1"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5369347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="276" mass="31252" checksum="3C0BB18158A71802" modified="2022-01-19" version="1">MSLPPLSLSILGVEPLDEFIKEVADFIHHTIMKRPPEYPTGKVEVEAKIGVLRERGGNNRLFLPVLVETILRPDVECRFESNMQPQQHKHFNGLLNKLKITSSQPGYASSTPLEYSHLYLVDSFYPSESSESRDRIRVTRDEKTGNVIETMKKIRLGDLNVYSPQRGADWRISVNLEVPVQHPLGSAMHTRRKDRLSYTHEEFIIDLTQVTSTAGGNHEVLHELEVEIARPELLLATAAKRGDPNASEHERSAFDELIRAFVNNARILVRNSEPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS17</accession>
    <name>A0A8H5GS17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_001089</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS17"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="865"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5370077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="900" mass="101387" checksum="5231C265A175E738" modified="2022-01-19" version="1">MDGRQPPSVSSHDNYSEEPYGDPFADRPRQTHFAEPPHPYPSSHSSPAAMPRPFESSTSLPHEFGGHSQFDDDEVEKQPLTGGQTFAGGFYPPGPVDPNAFGDPYAGGRPDSVVSHSSLGVESAWRRRQTIKRGVTRKVKLTQGNFITEYAVPTPILSATEAKYTATKTTEFSHMRYTAATVDPDEFTEGNGYSLRTKMYNRQTELLIAVTSYNEDKTLYARTLHGVMLNIRDICKTKQSKYWRRQAEEGTPGWQKITVALIVDGLEAMDKSVLDILATIGVYQDGVMKKQVDGKDTVAHIFEYTTQLSVDASPQLVLPVPEDPNNLVPVQIIFVLKAKNQKKINSHRWLFNAIGKMLEPECCVLIDAGTKPGHKSIYYLWEAFYNDPHLGGCCGEIHAMIKGGRKLLNPLVAAQNFEYKMSNILDKPLESSFGYVSVLPGAFSAYRYRAILGRPLEQYFHGDHSLADRLGDKGIYGMNIFTKNMFLAEDRILCFELVSKKNDRWTLTYVKPSKAETDVPETAVELIGQRRRWLNGSFAASVYAVVNFFQLYRSGHGIFRMFFFHIQALYNIASLVFSWFSLANIWLTFSILIDLLPGQNIVIFGTPTITHWVNLGLKWLYLAFLALQFVLALGNRPKGERAAYTTTLWVYAVLSFYLLLCSIWLTVKAFVNLPQTIDENGGSIAKAFFTGPVGALIAAMLSTFGIYIFASFLYRDPWHMFSSFFQYLLLAPSFTNVLNVYAFCNLHDVSWGTKGSDKAEALPSVSSSKSKDDSVAVVEDTTKPQEDVDAAFKETVTRAVTKVEVKEVPEKPTMDDENKTFRTRLVAMWMLSNATLAIAIENLNGLPSGDFQADQDSLRDKQQTYFAVILYSTFALSFVRFVGCLWYWFKRNLFRFCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTL1</accession>
    <name>A0A8H5GTL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTL1"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="275"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="45765" checksum="70A94A1145B2D222" modified="2022-01-19" version="1">MQFEILAKCHTTRARVSRMILAHGETMLPTFMPVATQAAIKGLTPDQVESLGVTLILNNTYHLNLRPGIEVLNRAGGAHKFQGWTRNLLTDSGGFQFVSLAKFSTITEEGALFESPFTGEPTMLTPEESIRIQHAIGADIIMQLDDVVPSLLKGPRVGEAMERSVRWLDRCIEQHEKSGRQNTQNLFAIVQGGLDHQLRDRCLDAMIERKDRVAGYAIGGLSGGEEKDVFWRVIKQCAAKLPEDRPRYSMGVGFVEDLLVCFALGVDMADCVFPTRTARFGVALTFQGPLNLKLSRHAKDLKPIDETCPCPTCKSGISRALLHHTATHETTAAHAVTSHNITFQAQVVGQARNAILAGEFPSYLKKFFATYFGDDGYPEWVVNALRSVNVDLLEGNPEAHVVRGDGAKWEYSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUE7</accession>
    <name>A0A8H5GUE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1314"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2731" mass="304103" checksum="232C27FB809E92B1" modified="2022-01-19" version="1">MGPRRPSAAITSNTPNPSTNSSSTRVHKSSDSHHIFGQSHSSTSLGASATPQNKIVTVLVNRLKNKLPCHSGVALDRLESDNATQQAVDALINLSHESLDMIAFNLGDLLQRLVEQGDSTGHTVEILQSQLFVLKVLSVAMASRWLSCNPRSSSRTSTDDARRAANRPGSADQPSTPIPWLEPPPLEESCAKYLLSVMVLFLRQTTIQDNSLLMPFSSFADISFRDFETAETPVAAQLISSQERENSVNGNRVNVVKQELRERPSSSSFKSTGKLSTCSYIVVPGANATYEKTHMSLVNSTVSLNNHIRKFAGRIIFHISASNWRVVFHRLRSKIHLLASDDVSDPTDLQMLTHSLLDKQRLIHVFNELSSLLVNMGPEAHKAIAGPLRSAIWSWVDHFPAEFNEVVRSRSKLEGASGVFDLLCNKSAGPESGLWPCLTILHSINTERVAVDIHSGGGTRATTRAAKFTEEMLRQTNLHSKPGQVSLVCESELCRAAMNVKAGLDEVPLQMLAYDAAHEIKSHLYNPARKSFWEVPDDIDVGLYAEAFVSVFRFSPEEDAFNIFKLAVEPDRSEAVKMCVVRACLTLSQEAPRFPWQRPLTKLEALVAPRLRAIHVAICGRRPEADQYGTMKRSASRPKVRHAQVSAVNDKELLMLALLSLWRVRPTFFLAELAEEEMEEWSNGAMRVWESPLNIAVKISYATTSMSHANLSLAMKGTEPGFSVTGMHFALTRTLTSVVSSLMNERNNLEHQRLWTRYTLNILELFMRPTENLAIRAVQRHQDRVPAFMLAEIALLVSLPSADNDISHVAAQGLRLLTHLENQVDAPVNNIISEDDKGKRYPVYDRLGDPKVMVVGRVRHQKRVRKLLRLMPYYATVNIAVWTECYWRWVALTEFVIDELGKNTADDVTIRMRRAGSSATENVYQWQNLSLFLASTAGGCLQDFDPHFLSAAVPTKYLPDRLRQLDNPIRHVHDFVNDLTGLLIFEELQIRDVAREALGAELSPKLYGRIIKYFDDIAQATDIKETLQVREIRETLSKDKMLLFIDQFIAVLKLIAENTAARQEIVSIDIGATLLNLATLIKGYGATETFRLKSKFCSLCESLCDRTESLMLRRDGDVRRNLLDIVVKWIQLPDASLDSVNQYDLNMACLRTTVKLLDRLQLTSSDSSNNDDSAHVTSRLFNKYSTVLLNGFEYCLTENLTSDSVSELGSIQLKMRASNRETEVRELIITGLSYLVSANTESGFKQCLPLAYNEDSRKRSIFAHVFARVIGQGTKFDAEDRSISVNRQNRLAELVKESDMTLVVAICETCPPTEVDGMINVLLNLFDTRASLMKLIKIMIDREVANTENEAALFRSNSTCTRFLSAFARVHGYNYLRNLVGPLIKIMEALPAGQGYELDPTKAGDQDVVQNRKNVELVAKSFLDLISSSTSALPSMFREICVHIAKTVYQRWPDAKFAALGAFVFLRFISPAVVAPETIDLESPNDSLRRGLTLIAKIIQNLANNIFFGKEAHMMVLNDFLRDHIAHVTRFLSELNRYTPGEDDGDEWLGTAADDTDMAVLHRFFDRHADKIGKELLSITKPSADSGKRAWDALCTLLVDLGPPIEAPRLSMLTSQEHRDYLDLMARFESKSTDPVQNIYFEVRPPTDTNDTGYFVCRFNRIDVEALDIELLMYHMFKLSRSQKYKDAYCEIIVDCTDFTSVSEMPIPWVKYAVELIPSDFRSKILRTHFLNPNTLAQKYLRRLYNISSGKASFLLSTDSSELKIIQVMCFFGEVKTWSSIADLLPHVPASVIESPALSEALSLEKESSDLFADVTMKIDQNRVPVNFTVGATHIRITSVRAVNISPGVACKSTDIVLLADVSDVYNVQTGHEANEFIIRRSRQGDTLYFTSPARESIIRTIRAAKARLRDHQTPMGDRFMLFSNVPATLLHIGLLSVDPFDEELRSAAYDLLGAVCKYLNYEKSPIVSTKAGFIAGDITMFVVNLSGRIAQFAPQLTLDFISEVAAGISTMEKKSSQHIALRLNCLRYMSPWIKNLDLFANPLSPLYDRSGARLRDCIRVLSELAIKVPELGTAAVQKYVWSEVARLESGVVDIIFDELVRTAADGGIGSFRCETIAYSVAPLSSINVRGRLYSKLRKAIIKASPRLSKSPADNSGWPEVATLLRIALIAGFETCNPAHNQLYVPEVVHIISLVAGIGSTLVRKTVYGIVVNLLQSLYMPRLEDGTEQELAQLIQDCSTSDVLHLFGLHRPTSTSEYCSFDIPSDKTSIDMQSKLTALLARTLEVLACTRGQLNVWRARWMSLATASAFQYSSMIQMRSFTALGALAVSDVDDDFMYQMLMAFRTALAQPEGSDTVALVSMLRCITQVLPGLPSDSRHIPQLFWLGVAFLQSSHMAFFEEAAHLVVLSVKEMESRGMFEDSTVPNRLLDARSAIEEPAQQFDSTLQLSYDSSFSFSLAATVFKGVRHTGLKDAAEEVLRTMLSVTVRVAAQVPHESINGYSDTLDPDALGFFLALIPLSTTTASYRRLLQDCEIDESLLPEEQVEVADESVGLPVVSMDFLGIIDGTTALLVTSFIGVMLMSAQGDDAETEMLYGLLADIANVFPETIQMAYESLQDRIKDIFANSSNPSIIRYVSEIIRIALDDSLRAGEHATGPRIGVLRNSSSTVNTMDETSSVHGPGRNHLRALEDQGMQGLSKNFQFLQASHPSHSTAAARVLNLIANLVTLMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUQ3</accession>
    <name>A0A8H5GUQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUQ3"/>
    <dbReference type="OrthoDB" id="3217549at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65045" checksum="D1322AF6F2B11BA7" modified="2022-01-19" version="1">MSFTSLCVKCRSAFVDESSETPPSINTVRSQLRSGYHLSKGDITQLFTLMEQTERDMERIGAKITVLEEMKKRLEVQRKVLEKHVDECRGLLSPIRQLPVEILEIFFSHYCSGSPSLIVGSRGIENIGPLVLSSVCKLWRDTSLNRTSLWSRIDVNLAAIKKQRITELIRLYLERSSPSPLTLNISWVVDTNSERRRRGRTTKQQGQLTLSLLSILETASRWQSVSFGFTSGLIWNVIPKKHDSVRFDALRDLDLLESSFTSDGDFVDFFLSTPSLQSLKLSEFCLKYPFPFSQLKALTILDPFAVGSRDICHVFTACPALEELVLEPTYIGLDLTILSPFPQITHPNLRALTLRMRRCDSLLTLVSSLTVPNLKSLTLMGDIPASQVMDDPKWRIWKESLKAMLLRSSCRLENLTMGAAAVKADKDLLEILALVPTVTHLILIHFHFVSNHFLRALTLDHSSSTSLDTAILPNLTHLDLTVFLHDGVNRCPQPDQEILFSMIKSRCRGSHLRDFGLAARVAHGDASAESWVQVFISRVKLRLDELEEVGLRWALDLPLTDRNRSIYNSVALCIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV68</accession>
    <name>A0A8H5GV68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV68"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12480" checksum="C57243BCB064FCE6" modified="2022-01-19" version="1">MHEVLLIPELLQHILYLVDRESLRACIFVCDAWKADVLYVYWETAHGIETIARALGAIRKRDSENAGEKVMGFDSLPDLAAWERFDSLYSRAVRERSVDLTKAIPISCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX67</accession>
    <name>A0A8H5GX67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX67"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="512" mass="55230" checksum="1F63264F559FE0FF" modified="2022-01-19" version="1">MTLPPLSEKEDSEPVISGMKVKEGPEEVVIVVGYLEHGISAYYVHRDNLANVANLQLYWTLGPRQGHFLASWDIYQCQQYWVVAAHNLCNGIELYATNPVSEPDIAQYGQLVSATGLQHKNRVLPVGFLADGQWLVYGSARGNTFIIDHNTGRKVEILNDHNDPDCSVFSLANDDKGVERIVAGTRDGWDGSITVYKYNETIAPETPRGIPLSTSPNWDTKSPTLEEGGAPGPPSSVPKSQLQNESWKSCFINVLGLVVALTALALGYYGSRPTSSHEGPSTTTLVQPGSAHTVDPVVISGERFPHPSPMTTVFKAGTSNTSPTKHTETVTSVIAITDTMTITMSPDTRTVTMAEKMTVTMSPDTMTITMAEKMMVTMSPHTKTVTVLPAMKTTECDGGALDNVLTCATNDPTVETVTVTASLIMETVTGGQEVMRAIKMLYDEVVQLKEKLDSTASLVAKVSSMVAATGDWSKSLRDGVLLMLAGAAVTLILVGKARHTKANLKKEVEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY91</accession>
    <name>A0A8H5GY91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY91"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="144"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="652"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5373184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="96215" checksum="42AF13F95A4CFBC1" modified="2022-01-19" version="1">MTDRPSDHETAPLLRDPDADSEDGETTTSNPTWNERLNSLAQEPLTPLTKLLLCVSLVLLILAAVFIGLFAGVQHKLNSERGRNGDDGKPPSTVTFTATSTVLTTTTAHPPSPTNAPEVPVCLTPQCVMLSSSVLSSLDTSEDPCENFYEYANGGWLRAHPLPSDKGSFGNFEALAQENEQIIQRILETPSTSSFKTSYDEQILGKLRGFYNSCLNETRLDERGQEPLAEFVQTLRKLYRGKKLSVSSTPEEQKEQEGRHLTEALAFLHSRGIDALFDLAIEGDVGVDPNHMVLWFSQPGLGLPSKEYYQEEEIREMYQDVLTRLILSVAEAEEKTLRQKEEMSTLSFTAQSENVWPPWPWPPWGGDGDDGDDDKPENQTVKAYKLAKKVLQFETKLADASLDLDILFQDPVATYNPAPLSNLTIALPQIHFKEYFAAFTPRSFPDRVIMTYPPYAISLSDILDRTSSEVIETYLVVRAALTLSPYLGMSTPSWQAQRTLYEVLSGIKKGAVGDRAEYCVEQVEEKLGFAAGRYFVNETFAGESREKGTKVITDIVKSFQRSLQDVDWMDEKSAKAASQKAEAIRVKVGFPLSPDTRDPASIANYYRLVQGDEDKFFENVLSAESSDKFKAWLQLGKQRDPDSWEMYPSMVNAYFNPPANEIVFPAGILQPPFFNKDWPSYMSYGAFGHVASHELTHAFDSAGRLYNQDGKLEQWWTNETSDGFNEKQDCIVKQFSEYTIDDGKGGKVHVNGNLTSGENIGDTGLIQAYRAWKAQYNESYLAGNEEQLFFISFGRIWARSMKPAAAVQRIRTDPHSPTKYRVDGTVFNIPEFAEAFNCSKKAKLNPPREKQCIFWGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0V8</accession>
    <name>A0A8H5H0V8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0V8"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="556" mass="63757" checksum="8E3120C3019FA032" modified="2022-01-19" version="1">MGESWFQREFLNARRLTFNILFYGLHFGLFAYGWYSQETNEKLKALNALTWSVWTSRGAGLVLALDGGLILIPMLRNVIRVVRPKLQWLFPADENIWFHRQVAYSMAFWSMVHTTAHYVNFFNVERTQVRKQIALQIHYTQPGGITGHFMLLIMVLMYGTAHHKIRNQCFEAFWYTHHLAFFFMLGIYTHATGCFVRDSTDPDYISSFPFYSTEHCLGYLSWRFIIWPGILYFGERVWREIRARRATRLSKVLVHPSGAMELRIVKPSFKYVAGQWLFVQIPELSQWQWHPFTITSAPEDPYVSIHIRQVGDWTRSLGDRLGVGPSVVAAMTQDAMKGAEKDEKGLRGDFVELDSSTGVSLPAVRIDGPYGAPAEDVFNVEVAVLIGAGIGVTPFASILKHIWYRQKRGNLGTLRRVEFFWVCRDAPSFGWFQSLLSEVEAAQADPNFLRINIYLTQKIGEDMLWNIAVNDAGAEYDPLTLLRTRTMFGRPDWMSIYGQMRQAIESGQYIPGSKSQLKTKVGTYFCGPSVLAKAIKEATVHHSCENVDFSFAKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H158</accession>
    <name>A0A8H5H158_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H158"/>
    <dbReference type="OrthoDB" id="3255427at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="365" mass="41332" checksum="E73545B6F22BD073" modified="2022-01-19" version="1">MNYQYYHQPPYYAQQQQQQQQQQQIPPNAYASYNQQMPALWSNNTPYMRSNGLPQTMQTQAPVIPTAGLNNFSRPERSATLPAGYPGRSALKRPRKMSKPTEKAAEGFHYVPGPRKRTVSNPQGDNIPTPPGHTEPIQLFMSLHGTNELHLGQLSITAIDGVRKSVVAIWPHGFDIDDMDGEVWRVRFRGTPWSFTGPDAHKALAMLQKLFQEFSEYGWVFQTSVNIGTTSPRLIFIRAKRRVISFYLLYFSHSTCRVSLINFPPRVRTHLVALLQQQKVAAQSNYMEENDTMDIQVVEMKKVPGYKTSESESAHFLAGLLSSLDTLGFSLETAIPIARKGPFSWLGVGPKQELFLFRSNQAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1E7</accession>
    <name>A0A8H5H1E7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1E7"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="137" mass="14910" checksum="700D66D640A74A5C" modified="2022-01-19" version="1">MSLSLGNKRTTSDDPFDSFNNTPSSNHARSMSIASPFSNSRSYSSSLNPFSNSTKSPASSEPPPYIARKPELDKPLLEGVARAIALYDFQAAEAGDLGFQKGDVITITEKSDSTNDWWTGKIDDRKGIFPANFVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1E9</accession>
    <name>A0A8H5H1E9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1E9"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="232" mass="25982" checksum="38F8090ECB79C1BD" modified="2022-01-19" version="1">MTDSGAVADNGPQVIRVTQGGKIKAWVSFSLESLQNSESRPLVYHTLPATIKLDPNTGSLISGETHHDKNKQKANAHNPMSTTPRLISVVEIIKREYLKSLVQKRSPRRIGLHQYNEIGLLDDLQLRDDVNCRGGRGDQQEGNDIGSSEKDMEQERLRQESIALALEGKNFPKQKQAPYMKITLSVSELPELVKRGATYQPPQVRRISKSAKARARKSRKKQQHDERALAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1L2</accession>
    <name>A0A8H5H1L2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="4 15">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_000546</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the NTE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="4 15"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14 15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="595"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="731"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="18">
        <location>
            <begin position="1079"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="396"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1644"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="14">
        <location>
            <begin position="1110"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="14">
        <location>
            <begin position="1230"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1652"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="1112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5375286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2062" mass="226778" checksum="ADD94288DAB09BE7" modified="2022-01-19" version="1">MEAPPSPPDVDRHPLVSLVSASFWVILWALSWAKALVAFLTISVPRLIYSILSYSLTLTLNFWSFAIIFALSAVALNYWIRFRYLNDYTQLKEPPLVKPDATELHPDVNTDATPTFHNYLDDFLQAVRVFGFLEKPVFHELARHLQTRRLIAGDSISLDQDKSFYCVIDGTVQVFTQTGRAEAQLSWDEENMNGYQLLNEVGNGGTLSSLFTILSLFTEDVKMSWQDDHTENMPFGRSRPSLPIHEISDFELEPTDPHRRRRSSVSSTTTASTVHAFDFSSPPTASRVTSRMGFASPISEEAPSSHEADSPHNDSAHHGLVARAMEDTTLAVIPAEAFRRLTKKYPKATGHIVQVILTRFSRVTFNAAHKYLGLTSEVLRTEKAINDIACHPLPPSFYEGGGLQNLRNRFDTGRSDSDNDYFSSQSPSTRTLSDSLNTNLESHTRAKHPRPERQSTFTSTSTSTSTSTSLNRVSRSVVQAGDLHTSAEHPNGHSNSNRTSNILNTPLISRNLGLANIGDSRRATNPPLSGSDSIEASPAVRPADDRSSFRAPGSSFSSLSLLDLNDDASSVTGASTVASNDGYMSGLDNEVEILYFTAGSTLARAGELNTGLFYVIEGFLDILLPESSPSDKTPSDAKAEANTAPQRKDRRKGSQQKLLFTVKPGGIAGYLASLCHSASYVDIKAKTDTYVGFLPSHALERLLEKRPIVLLTLAKRLISMLSPIVLHIDASLDWMQVNAGQVLWRPDDRSDSFYIVINGRLRVITENDEGVQIVGEYGQGDTVGELDVIASSRRRNTAHAIRDTELIRMPQTLFNAISARLLRTIASRIREEVDASGSAKARNKRTADIGYNNNLKTVAVLPTSRSVPIDAFSRKLQTALEGIGASTAYLNQASMSNHLGRHAFTRMGKLKAAGWLADLEQKYRTVLYVVDSAVTSSWTQTCIRQADFVLVVGMGDDPALGEYERLLLSMKTTARKELILLHPDRSVVPGSTREWLKVRPWVHQHLHVELPGLILPIAKSAVPHKDPDPMAALKNLKDIVQHEIQKYRGGTRDPRPQRLPHINDFSRLARRICGTSIGLVLGGGGARGISHLGFIRALEEYGIPIDHIGGTSIGAFIGGLYSREGDILSSAGRAKHFSSRMGSIWRILSDVTYPLVAYTTGHEFNRALYKAFYDLHIEDMWLPFYCNTTNINTSGMEIHQTGYAWRFIRGSMSLVGLLPPLCDNGSMLVDGGYVDNLPVSAMFSMGASAVFACDVGSIDDNSPRNFGDHISGWWLLINRWNPFSDARLVPAITEIQSRLAYVSSVGALEDAKSDPGCLYLAMPVQEYGTLQFSKFEEIQKKGYYAAVEALEKWAAEGKLPPVLINGKDEKVSVKVRSVSLSISCASMSNEDSAKPQENDPPVNVNGAKTLVLDSTLAGPLGLITEASLLKHHGVDKMFWLEPGPLSSSTTNIVYLCRPMIKYVKIIADQIKRHTKDSLKHNYNLFLVPRMASLVSRLLEEEGVFGELTISAYNLQFIPIAEDVISLERESAFKELWVDGDETIIYDSAQALISLQKLFGLFPRILGKGDQAARLIKLLTTYLPQSRSSSTPDTLSEVSDEFDSLIVIDRRVDMVTPLLTQLTYEGLIDELLGIKDCHVELPASLVTPPSGPAPSASSPTTSDPAPSTSAANLRKENKKKYHLTDQLFMDLRDLNFSSVGKRLNRIARRLDEDYKTSLQAKTIPQLRDFVGKLGGLQTEHQSLRLHTGLTELMTPMTRTDQFNKSLEIQQSEIHLELELAPANWFIDLLASYHVSEQLTAIEDLIASGTDMQIIVRLLCLASLTAGGIKTKTLENIKREILQAYGYNLLPLLLSLASPSLAILLPNPLPPSTPQSVLTSRYPFTSLSKSLRLLIDDSPEALEEVENDISYVYSGYAPISVRLVQCVAQKGGVLSNPAEKEKPQSVSGADGGGAKVQAHPIVGWKGFEDVLATIPGETLDIIQRGEEGTSATIRNLARPREKSTTTVVFFLGGCTYTEIAALRWVGRQNRGRRFLIATTGIISGTSLIDSIAGTRRAAQGDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LF58</accession>
    <name>A0A8H5LF58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LF58"/>
    <dbReference type="OrthoDB" id="3221235at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="577" mass="65337" checksum="7EE550EB97E08F5F" modified="2022-01-19" version="1">MTTATTTTTLDSPFSHLLSSNYAASDSDVPCVKAIINSSSNTLRRLNSEIRELEQKRDSVQTCIDVHRALLSPSRRLPVEILSEIFAHCLPRDRNPNCSQSEAPILLGRVCRTWRHVSLSTPSLWASIHIVIPILASRSVLRSVIDARREGVETWLGRSGSLPLSVSVFSEWSSTPLTYGSPDNFPERIRLLLDCIFQRSNRWHTVQFHLNNDCTSILSECWPWGGTKELPLLHTFKMGLSVDAWGSFPNFKSEWLAKAPRLQRLSLRDGDFEWFLTGQSSWAQITHLELQVPNVRLSSIIKGLRQCSHLQSLTVHGLCVREDTLPDSIQTISLPSLRSLSIAGRIGLTDYTNPVDVRNIFAYLDAPALRCLRANINREGRFECIPFIGLLGPGNQIEELDISFQEDLLDDILSLLPNLSIARIRPRWLDNTLLHRLTSSPGPDEPLCPSLTQLYLLGKNTTINDEHLLLDLARSRWNSGILSSSHTTARHGGIARLDVFHVLLNQYEQIPSLRDQLQELRNQGMDIIFAYREEESMDPSSGQVADEDNIDPYITHSRYSDQISNGMIRKHSWWLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHI2</accession>
    <name>A0A8H5LHI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHI2"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="153"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="989" mass="113090" checksum="06F61421B184FE96" modified="2022-01-19" version="1">MTSRAPKRPLESPKGPPNKIPRLGSLGVQDTPIFLAQDEEIQEIFSTVPVPFAIKWEVARLGKEHYDRIRSELAAYIDMSNYGAFAQFEHDQDKSTLLSEKEKAAISPWTELDQEELAFKQDADYGGIGNNSAFPDWYGGKVDLRGTLQKNMSIKLEMCTLGPSNKAKRRFGSKSFIRIKIPDNLRFHQNTDFVSFFKHPFVFWGSVFRAFYAKDDSVFLYLTNETYENGAFKKHPERLPLYSFVEWANPPELNKNQKACKWSSRMALILSNSVPGPRLLQPNISTIPDIISISDSKEESNMTDGCGVANLALQKVIRDQIGLQEIPTAFQCRVAGGKGMLLLDRNWLCNSPSLSLRNPSQIKIQYIRATEAMDPSHLTLDLLRFAQVKTPGRLSAEVIINLEYNGVPAQHFVDLSKQAMTDLVTSLTTWEGKDAMFNLWRSVERTECVVSARRSRESVTDGRLKGFMDLKEDDMKDDENADNDKTDQHSSAWWPDPVSGCPSSLAETVMTVLDAGFMPQGCPYLMDKLKQVLKYQINHLMNKFRFEIEQSATAFAVPDIYGVLGPDEIHFKSSRREFLTPDGHYDLIIGDVLITRSPCKVPSDVKAVSHPDLSGLVDVVVCSVTGPRRLLDYLGTGDYDGDRVTVIWDQVLVKPYENANDEFSLPPAGLDDCFELQDEMVSDILNNSRRSDRTDRLQNYLLGSLRTPSIVGEMSSCHDRAVYYEGYGHPEAHKLAYVTTTVLDGAKSGHKIKADVQKTYKTKYDKEECPLRWKEERKVDQRDKQQFVSHSNRVVHLRKRPKELGPFIMDTIQETTLKDGREWLLKAEKEFFRTSSIKPDEDLLEPYKYVKRVADERQDANYLSDLELIAKHVRSVYRKYSQKKGTSFSNKHIVHRQDDLRSCSKEFASFPKPEDLKTIMDNATIARLRASYAYHFDVFEREPERSVRWSRFPWDMALRELCAIKVRALGPWKASTQSFYERFKLAKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHK2</accession>
    <name>A0A8H5LHK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHK2"/>
    <dbReference type="OrthoDB" id="3259878at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="33524" checksum="22EC5B01A3D76856" modified="2022-01-19" version="1">MARRAGPRLHRLPQRLDYTLIPAPLDLSLPLVAEKSPLPAIIVTPSSPSDLDFDAPWRHGHSSPDVHTHDYSYGEDTHRHGTNNNYSIAFLAAPRKPTLSQRISEMTRRWQSSPPPPAPSSPSESSYFPLTPDPYPSTPSKSKFRIATTRAHLFNGFGFGYGKGSFSLRHGLGPFLLLSLILFVMICHLITHQLASSGPSLDLQFASSITKDAVGGVQGSLNINNMHGNMNGFPGIHGSLAMGKMVPGPGERGTDSDADASNVKSDADGKEHLGNGLEKTDGDRFPVPDEGRLDDVADVAEVQAADAEVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHK8</accession>
    <name>A0A8H5LHK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHK8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="81" mass="8471" checksum="91276E161F329A47" modified="2022-01-19" version="1">MITGGKIEPYEEELEGESEGNTSPTPAPTPKSPPPGVSPSSSPASGVYPRFIQTSTPSLADNKKLGEENMTPASLFDEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJU1</accession>
    <name>A0A8H5LJU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJU1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="309" mass="33505" checksum="EC6079829E7B104C" modified="2022-01-19" version="1">MTLSRLGYRNTIIPLKAPLHARTFASTVISHRPRRTLLTLGFSAVASLTAYTIGSVYPPPALSYIYSPYSRSSSSSSSVIQSTPSFSPSELDSIESQLLSLPLLQELRSSSSSNEYYLTRPYSSIPEERRVNNLTAGALRGPGRLAVPPVVWAKKDESEAFVFVHVGRGLCGHDGIVHGGLLATLVDESLGRQAITNLPDRIGVTATLNLSYRAPTKADQFIVIKTKLDRAKGRKVFVSARVEDLNGTLLVEASGMFVQPRYAKLLNSTSIQQAIGEPPSSPTASSNSTKPEPLHLADGEKLDNLRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJY1</accession>
    <name>A0A8H5LJY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJY1"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="150" mass="16532" checksum="23241939324BAE7D" modified="2022-01-19" version="1">MIQVPPKPDPWNCRRTQVEAMSCFSSYIKDPAQVPMMFNLKFQTPLMLWEWSAQPGRIPAVMKGTGTYAQYSAEGVSLQENYIMVYVGGSAGSGACLTLKKAFPQLCYVVQDLEQPIASAKRSPTLLTHLREAAGSESKLKLVAFAVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LKB7</accession>
    <name>A0A8H5LKB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LKB7"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="478"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="881" mass="99793" checksum="CBF52B258BFE1614" modified="2022-01-19" version="1">MKGTIGIPISALYLFSPDMPPTFPPPRTGTPTGSPPPAPTQAAAQLSQATPHHDRISSRTREDYEEKPLVAHQYRWLEEDLAFTALISIEEFLQLVFAPTNRFNDSKKGELSRLVRGFSQENKKYKDARQKYLEECAKQKGIVDSETGRKLQSQDIYETQLYDPFAELCNIVIQEMGFLTDDDDIAEDNRVLFYRQDPYVIGGLTLTQRKSDLGVLGQNGRRLLDEFKGDTDRLAKNMMWHVLAHWIEMKRLNGNTLLSNSKQVAFSATPKDETVPQQSQAGTSASADSNGKSTMVSTASSGRKRPRELEGTGKATGRKKAKTQRPAATVVNSETPSGAKLDAVARKRKQTNDAHDLQLQNAGYALEMLSSGCLRSHVIGMAVDTKSVQFSYYDHSGILLSAPFSIEDNEQLFLSILYHFRGLNAKQRGFVPRPQLHSPPQLEEPCKRPDGTSFIPIYHDAVIQLGEYHELRLGEHLYTARSIIGRGTLVMAARGDHSSTFEYVVKISFPVKNRTSESRLLWKAVKVAKSKTEWQWVEKLLPKMRYWDDTDLSEANGFPHQRIKAFWDARLGEQEDLSSFYEERILRVICEEMLHPLTSLREVSEYAQVFCDILQGHRWLYDRAQILHRDISMQNIMVRRVPNEGKVYGVLNDLDLSSEYLTQKGPSCSDRTGTRPYMARVLLSKSLKGPHLYRYDLESAFYVMLCYFCRYNLQGELCTKEYDKWYTGNATDVLDSKTSLFSPAVTVGYGQAFKFNPPVTPDFLPFVPILVELYERFLVADATRIMTGLRGELFEEQTANNTITYGNFLTALQKFGDGKVVQVYYPDSDTVPLGTLEVIPDPSDDFESMMGRWLDDVDYSQTSPGIEEESKTEDNDEQEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LNX2</accession>
    <name>A0A8H5LNX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LNX2"/>
    <dbReference type="OrthoDB" id="9908496at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112243" checksum="85253B059626A17C" modified="2022-01-19" version="1">MPLSEDDQRTAFGYAEEYVDSFIDLQRRFLNEGKSAVHDPAVKAEVMVQIKEKINIDKINPTRDPRIRERLLGEEFQKFLYIILDEMVDARWNDDPKLDCQAHIFRVCNTVQPSPSSKMSLPVLQTVTSQLSASNDSSAASAVKVKSQPLSPAIFFQVSTEPLSSSSWPPIHERGRDKASVCSSTSSSTLTPVSPASSGNPLHVPLVRAIPKGPPRPIITSKSSGTSTREARSRAEKAVEQGRKSQDGNGITQDKGKKAKETAVDDNDMVEEDDPPTSSRAISPDNPNQDDSMDLGEGHIPGLNHPPPVISATAMLPSEPPPPSPTSSKRKRESFDEGVSNRSPATPRFNSASSSKSSLTPFSPSPISSSHYSSQSQSVTSKFVKAEDDEIDTKDHLLVLAKTYAHITEEAHGNILDREQIIREQDQLIDDLNGQIYTLEKQNAALQFAHSQSEVTSEVNLQAALDEAMELLEAERAINAELRDAKTSLDEKIQSLQAVQLELGRQSQLLLEVQASLAAKSSSYDNLSATLERTQVEFAEAIKSLADARANLEAKTAEYHTLSTMLDSTGLKVDEQVKLTTVAEARLADKTQSYNSLSDTLTATQRERHSTVGALVAERDVLIDRLAAERRYLSAAQARITSLENQFRVVKEEKEQTSRDWSAALEDCVCKDNEIETLNVKLELQVNHGQKLLDATNSRIRLLKDEKDCAVEKAKVEAEKMYKQSLDNAKAEIESLKQEKVVMAEKSEKEEKEAKEAMRLQSARTQQLLDNAKAEIESLKQEKVVIAEKSEKEKEAKEAMRLQSARTQQSLDNAKAEIESLKQEKVVMAEQLEKEVNKAKEICNQAKLAKDDVERARVREDDLRREKQKLKNEADSSHQELETLRNAADSSRQEIETLRSDVHSSRQEIETLRSDAHSSRQEIENLRNVAATARQEKEELQFQVKLADSRFQDALQEFNRQGAKVAKEKKTLQAELVGAQEEKKRMADELDTFRSLMNRSLNQIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPY6</accession>
    <name>A0A8H5LPY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPY6"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="306" mass="33735" checksum="A95A879A938899FD" modified="2022-01-19" version="1">MRSLLRVLALRRHYSQVPWFVDTHVPIQPPTPASRAPPVPENTPQVIKALHAQLAQSPHLEHSELRVLDSSSGTQVIEVPPFPLRIPQGKRRRGGNIAGESMYDVPGTLWNWMVFAQVKEGTENKGGIESVVRIVRKSLLSVDPPLPIPPKSKKRMQNGWAMIDAGDFAVHVLSKERHFKCRPAYKVVLKAVRKHRFRNSSIMSLNDQNLGNARGSDVYPGVANPTSSSNSSDPMHTNFVTDPTSGDRGAGAGARFEGDSMAARNFKQTAGVVEGRPGIIETANIDPLNENSNKGKSRNLMLFTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ36</accession>
    <name>A0A8H5LQ36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_005458</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ36"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="49"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="349"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5365303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="454" mass="51013" checksum="1EE09C002B5232C3" modified="2022-01-19" version="1">MMRTTTTRLGLLSGHLRSPALASSSAATRAFSSSLKMQSNFKKIVVANPVVELDGDEMTRIIWKKIREELILPYLQLDIKYFDLGLEYRDETNDEVTVESARAIQKYGVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNLIGGTVFREPIILRSIPKPIPGWVKPIVIGRHAFGDQYRSTDFVAPGPGKLQLVYTPEGGSEPTTLDVYDFKGPGVAMSMYNTDESIIGFAHSSFKMALAKKMNLFMSTKNTIMKKYDGRFKDIFQEIYEKEYKSAFEKIGTYYEHRLIDDMVAQAIKSSGGFVWACKNYDGDVQSDILAQGFGSLGMMTSELITPDGLTLESEAAHGTVTRHYREYQKGNETSTNPVASIFAWTRGLLHRAKLDGNEKLKEFCDDLERACVEVIDEDGIMTKDLALAIHGSEMLRHQWVITDVYMDAVNAKLQKKLKSKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRQ0</accession>
    <name>A0A8H5LRQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_004074</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRQ0"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="239"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="819"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5367043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="929" mass="103545" checksum="59B358C5BB0C4D0F" modified="2022-01-19" version="1">MYNLVKRQFLSLSSRKTVTYGLNSSSRLAGQSRPVHRQFNTLLASGSLRSRYAQPSSATLRRIHARAISYSSIPRFVARAFRVPIAGAAVGAGGLGYANYKFEEFRKSTQSWMNTVQDTATDLFDSASDGIKSFRGRVSEVQLPQFEAPEFLKNLFSDQSEGKGEQQNEESGSGNQGKRPPTDEAAIAALVAATMSSPSDSKPDSPQGDFDAKASGLMNLTRKLIEIRSMLLSIDQNDALKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLVHTPTPPGEKPSEYGEFPALGLGKIKDFSDIQRTLTDLNLAVPASEAVSNDPIDLRIYSPYVPDLTLIDLPGYVQIASMDQPDSLKEKISSLCDKYIREPNIILAVCAADVDLANSPALRASRRVDPLGLRTIGVVTKMDLVPPEEGAAILAGNRYPLHLGYVGVVAKASGKKRNESTGAVVQRQENDFFRSHRDVFGASGTLMIGTDTLRKRLMEVLESSMASSLHGITNAVQLELEEATYQFKVQYNDRRITAESYVAETMDALKLRFKEAMSQFKKPIIREKLKAMLDDKVMDVLEQLYWLDKRAPELGELAADGRLGPEDVEAYWKHKLDAASSLLTKSGVGRDSTLLVADGLRALIDSIASAEPFNYHPRAAEMLVQFSHMILRDRIGVASDQVENCIKPYKYKNEVEVDSREWEAGRARAIDLFEKEIGMCEAKLKEIRKKVGGSRRLGSLVNYVKSLEEQKKERNARRLAASLTEGDGEQQEEVTPESYRYPPAQILDARHAILYTDRLAVLRLRTVALKSKRCKAGPENDVFCPEAFLNVVADKLAWTSTMFINIELLDQFFYQFPREIDSRLLYDLDRREIVEFARENPVVKKHLDLQERKDKLEEVMKQLTSLSTLRSDPQPAPRRNRGLFSSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRU6</accession>
    <name>A0A8H5LRU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRU6"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF127">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="935" mass="100340" checksum="BF5D56791FC370DC" modified="2022-01-19" version="1">MPDNPSSQPPPSSAPAMPSSPTGSATSPTSSSAPAASKRYRPAPAKTFQCRGYGECRMVFSRSEHLARHIRKHTGERPFTCHCGKQFSRLDNLRQHAQTVHADKQEHNDRMMRELTSLHATMSAASKGTGRGGRRANNNAAATSASKDEPSLRPGTSTGYEGASDDVEMSNVDDRSPNSSAAPHGSGSHSFRSNSNSSQSFREPIHQSTNQSFRSSATPTSARTPPPHSHSQANPSTATTPSPRAYSHSSHNNQSFLASASAASQHQSGGTHHSSSSQFRFNVADDYERPLSSSGAGWRELERDREFFQQRRPAEGTTSRPTTASGGAGVALPPLSAVIPAGIPPPLSAGSRPTTSTGNFAGFGSSFPPPPGSSSGLPIGAGRPGSSSGLFRFGLPGLGGPGAPPGSSSGYPAAPPSSSGLSGYGGSSHGYGYGNTQIWTGSETRHFPSMLPSAEEPSPNHLPAMDPAMVMDQHQAQQAAPTRENEDSPHSNLANTRKEKLNDREQVEQANMVPSQDPSREEFPSWHSANQNQNVNQAHQEVPYPHQAYYSLPSGQAQEVKNNKSQAAQVDQARQAGQASSSGGRRDSLSATGMNQRGGATMTKMEEAAQHYSAELARQQQEQLRRVKENQSPTAYHPPHTQETHSHNHPHQHPAVPQEAHTQTHQHPHQHPHPPTTHNSAPIHRQSTPRDPAAESMNLDLDLGLLEGIVAPYPIADQTHQPATHHTRTQMHDHLHQPHPMDMDMDTISVYQRQQGQGVQVPVQPQPRPLSRSPLDPQFHRTMGIPMDLGTMVPPPQSQPHRFPPSGHGPLRGGGMHPIHQRQPSQQQQPFIGNMDRGMGMGHINHGSPSAYGGMDMEYMNMGHFGMGDVDGMDGMNRMRSMNTNMDMHGISNMQGGMGPAGGHGHGRGAGTHAQDMNDVSSGMDLPNILKFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUN1</accession>
    <name>A0A8H5LUN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_001287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CWF21" evidence="14">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5370148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1587" mass="173634" checksum="B29F39C47588ED79" modified="2022-01-19" version="1">MLWPFTLKLDDAERRVICRPSSTRDFANAPPPSPCTTASVLRLREAGKYSLGNRIAQLFDVSFSGTNGYVVRNLSTLRHHESAQDRAAAWDAAPPKHREPDEAILEHERKRKVEVQCLELQLELEEKDVPEEEIEKQVDALRTKLLANLAAMAPPAKNLKASDTHGIAQAKKTELNKMARALGTRTDYVEGDAFDREKQEEIRQKRQVEREERERKREEDRTKMQEQKAKWDAERRERDRLRRREEDRLRREREEGVAHRKDRDMMPPPPVPARTDRYRDHGYGSRGRRDEPPRRHRDSRSCSPPVRDSRSPERSRRRSPSRSLSRSPPPRRRRSPSPTPPSRRERSPPPTPPHRTRERSSPPPRRRRSPSDSPPRRRSPIERGTRRSDSPRGRSRSPSSDSAMSVSTGSSRSRSRSPGMQDCAVPRGFGTEEEHKGCGQLVVDAHLLSDSAILIPRPAIMKRSVAGIHRLARRSHLSGVRFVASEAYPRPAPKLPSAPSTKYKAVTNPKDYTQSELTRTAIKRDSSYLLPVYARPNFVLSHGKGSYVWDTEGRQYLDFSAGIAVNALGHADEGVIKVVSEQSAKLLHTSNVYHNEWAGKLAELLVTLTQKAGGLGFPTGQLQTPPAETTGAKVFFSNSGTEANEGALKIARKVGKDRWAAAHPGQSWDSKECDKTRIACFESSFHGRSMGALSVTSTPKYQLPFTPLLPGIDVGKLNDFDGLRSLVREDTCAVIVEPVQGEGGINAASTEWLKALRKRCDDVGAILIFDEIQCGLYRTGTLWAHSSFPTDCHPDIITMAKPLANGYPIGAVLLRDTVAATMTPGTHGTTFGGSPLACAVGHHVLSRLSEAPFAAQVMDTSAYLIGRLELLPKWFPEILQPKVRGRGLIVGLGFHDPSVPGRVVEMARERGVFILTAGRTKTSALRTLCTSASPRFPSISVLTERATNCPVMGPALNVRSKEIVAGYASVAGVSEVEQIHKQQGVTVPPNATVEMCPHASAARAAARMAEDLSAAAAQKKVDAGTSSAKAAAAGCPFHKSATIGATASTSTQQPSAPLHKSSVSGGFDYDQFYNNELEKKHKDKSYRYFNNINRLAAKFPVAHTGDPKDEVQVWCSNDYLGMGNNPAILETMHRTLDKYGHGAGGTRNIAGNGALHLGLEQELAALHRKEAALVFSSCYVANDATLSTLGAKLPGCILFSDKMNHASMIQGMRHSGAKKVIFNHNDLEDLENKLKMYPKETPKIIAFESVYSMCGSIGPISEICDLAKKYGALTFLDEVHAVGLYGPHGAGVAEHLDYDAQKAAGNSPDPIPGSVMDRVDIITGTLGKAYGAVGGYIAGSMDFVDTIRSYAPGFIFTTSLPPATVAGAHASIAYQRAYVGDRQLKQVNVREVKRRFAELDIPVIPGPSHILPVLVGDAALAKAASDKLLTDHDIYVQSINYPTVAVGEERLRITVTPRHTLEQMDKLVRAVNKVFTELKINRISDWKAAGGRAGVGMGVESVEPMWTDEQLGITDGTTPRTLRNGQNAFVSPEGVASARERFNTLLGPIAGTVQANRPLETVLVEKSAAALLSNEDLKVPPTLVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUQ2</accession>
    <name>A0A8H5LUQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_001368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.620">
        <property type="entry name" value="Helix Hairpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="832"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="726"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1197"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="486"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1315"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="742"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1208"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1280"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5370011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1547" mass="175648" checksum="16B478EED3D09BC7" modified="2022-01-19" version="1">MDASVTRNIVYPSHQRSSRFPMPPRRSSRRSVEPQSQPVDVLPAKRKRGQAVEVVDTLEEKENMEDQEQQPTSRPRRSSSARASMNSTRSRTSTRNRSSMLEEVAETDDEAASDAPPPTKKKRPSIEPEEEADEDEEYEEEEEKPKSRKPKGRKPAAPRGRSARVSSQRRSKRTSDPSPSPSEARDESEDETPPALKTTKRSSKAKVVLDEDATMEDNDDLSAFEEPIKAKPKAPKGPSKPKSSSSSRRTSGADAEKEDEDEVEDLQKPTASEPLSVPPASQSGQMQTQAIPEEPQGPKSRLVIHKLALVNFKSYAGRQEIGPFHKSFSSIVGANGSGKSNTIDALLFVFGYRATKMRQGKLSELIHNSARYPDLDECSVEVFFREIIDLPDDKFEIVPGSQLHVARYAYKSNASKYTINHRQSTYAEVQSLLKGRGIDLDHKRFLILQGEVESIAQMKPKGTEHDEGLLEYLEDIIGTSKYKEPIEQALVQMEELQEHRSDKLNRLRLVEKEKNALEDKRKEAEDYLRLLNQLAKAQSLLYQWYIWQALVNEEKFNKLIDKLQSKLETEREKNKDDVTHLELLQDHYAQRVEVYKQVQQHATDASKELADKEKEEVSLSERKKHAVTKVKKSKKLVQEGTTALNQARNTIKDSDEKIQKEKKKLAEHEESLEREEKVLEGIVESLRDKTQVYHDQKEALQKELQPWTEKINQKQRDINVAAGERDALKKKAEDAAAASAEAEEKLEQLRTDQEAKMAQQTEHKTKKAELKSQKENLDKKLQDARNNEREWRAKSSASSQKVQETKSSQAESRSQGRVLDSLSKLSDAGRIKGFHGRLGALGAIPDKYDVAVSTACGSLQHMVVDTVEQGQACIEYLRNQNIGRASFVVLEKLSYNPAQLQKIPTPENVPRLFDLITFKEDRFAPAFYKGLGDTLVAQDLEQANRIAYGKKRWRVVTLTGQLIDISGTMSGGGSQPQRGGMSSKLAPAGVTPEVLRKYEQDSVEASRNLDAAVQELRNIEAELERIRTAGPQIDLAYEKLGLDIETGKKRISEAEKRLRDLQSQSQPDANDVARISTLEKQLKVCNKELEKIQEKAAEIEQSLKEVEEKIIQIGGSKLLTQKSKVEGIRTYIDTANAEITKAEVAITKAEKTVTKSQGLIETNEATLQEVSDELEELESKLEEVQNQVARYRHRVEEAEAAEETASADLDKLKGQLDEKTEEVEKFRQTETKLQKELEDAERDRKENDEKMTHWQEKHDELKLEEIDDDEEDGDEEQEQDRDNSEETDVKPDPDEPPKPKKAKAKSEGLPTYEEKELAKYKHRDLQINIESLQDQIKRAKPNLGVLEEYKQREEEYFNRLSDVEKVTQRRDEMKKTYDDLRKQRLDEFMLGFNQISLKLKEMYQMITLGGNAELELVDSMDPFSEGIIFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHVFKPTPLYFMDEIDAALDFRNVSIVANYIKDRTKNAQFIIISLRNDMFELSNRLIGIYKTANATQSISIDNHALTARAVENSTTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYD4</accession>
    <name>A0A8H5LYD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYD4"/>
    <dbReference type="OrthoDB" id="3258136at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="33470" checksum="6817C8E389E750F5" modified="2022-01-19" version="1">MQHASWAYNNIDFRAVFIFSKSSLSPSLCPTMLLKFTNSDMFNTSLIDIATGAIAYDVVTCIVDTPDTADLPEVALPFGIISPSLIASNHDHPTFANFSIRSDGNMKPIPNFTPSGEARKTEIRTGDGALVAEMKWDGRRPDIFVRDEHVGQVSSLFDLSNVKRGSDVLAISTRFSKEYEWNATANCVTLVNSTSGQTKGVFHQNTIRVPVSPSSASNISRHDKLINTRVPGLGHCYLEFESHPLVEDVEIIISFFIMEILRRGRFSLTPYMFERPRLWQLHEAKDMILRRLRRNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZI5</accession>
    <name>A0A8H5LZI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZI5"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5375293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13590" checksum="6AF4E3451CB16D63" modified="2022-01-19" version="1">MPKAAAGKVATKHKFVIDYSRPASDGVFDGADFEKFLHDRIKVEGKAGQLGENVKVTRDANKITVTSNIPFSKRYLKYLTKKFLKKNTLRDWIRVVATAKDTYELRFYNIAADDDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BKC2</accession>
    <name>A0A8H5BKC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000385">
        <property type="protein sequence ID" value="KAF5324965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BKC2"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5324965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="249" mass="28483" checksum="67A47EC40219BCA2" modified="2022-01-19" version="1">MMGKIYEEDDDYSDSDKESTSDSSSLKSTTKKRSWTLREVKREFLRDFKPTSRESQAQTKIETIRMEGALVDIDKYNSQFKLYAKDTGYNDKGLMKYYRKGLPKGLVDRISYLPSQPKNLAALQKVAVKQHMIWVERQTEKALWNKQRGEGGQQSRGSQGTGGSRMRSMEVNAFQSNTPGASSNTKYPPKLTNEERERMKREGRCFSCCEKGHTTWNCPTFPRSTTTNTNNTTFRPSIRTTTTTTEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BR35</accession>
    <name>A0A8H5BR35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000378">
        <property type="protein sequence ID" value="KAF5327977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BR35"/>
    <dbReference type="OrthoDB" id="3051194at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034834183" description="RNA-dependent RNA polymerase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="4">
        <location>
            <begin position="428"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5327977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1195" mass="134320" checksum="88F63F9379DFA318" modified="2022-01-19" version="1">MCYGLWDLTLVFTGMIYGTVSFADPHDEKSWIFCTVCYLHRPRQEVTAIHLDRVLNFLQSEDFGETEGINCYGLRDLTLVFAAMIYGTVSFADPHDKKSWIFYRVLDFLPSEDSGEIEVVNSVLRTTGLDGGVYGMVYGTVSFADPHDEKSWIFHTVPTSTKNGVYYKPTRFLLAISRLLISFWTFCNLKTGEIEGVNSVYIFCHGLRDSVVFTGLTYGLVSFADPHDEKSWIFRTVCYLHRPRNEFAATQLGLSRQFQDFWRLCFIHCVSPGLGQDSTQAVSLANFVGHTSPFAFVFGRRSRAIVRLGSVSIANSVGHTFPSLQTAFCTCGNVNTLARSSTASITWWYSYEPHACILRSSTRSLPVTPSLGQLVLFVMTPDINPRNDMELSRGFALRATGISVQYCALDAGHISRSHSRHRIFDLSILNMWNNKVPVQVFLYLMEQGLTETLRPLGEWRGKWAMLQLWDTISKIGRVSGTQLAMLVPSASRALGFSGRERARVEVGIVADEETSGSASTTAVGNVSELVVIRAILGEIRLVVVGFNPIYDTDMRDTVRFIETNTIKNYMDKLRIPLPDGTAVEAFAIPYPLGVLKEGQIYYKPSNFIKNTATGSRIEVLEGEVLLPHPFTFRYPEVDIPALKRWVDVVIVPMVPVTQTYHDYEKMSLCRFKEHPSFYDFKRQVERVLQFTSRLADLPIEERQRAFQQTYLAGMAHVDVGLYSAFHDAAVWVHGYDSQAATRLAYNFDNMLTIFRFNYVLDSPKTGLRLREEVYVKGMQRKTFEQLDPAGTGKLIIDLLAKAGEDLGDRYLHEFDVNNGLLPEHIANKTTRPDQDLKKPWKDVQDLVQNYSSDNLPEAKRDVIRAALKAELDLVTEHVQKSYDEFRRGAASSSSSNNVYDQPTKKRSGKAPRRDCMSFAKQEYAKHISGISLLSEKVERMKASYAYHKSEKFGNCVGFKQLCAIKADASAQGSAPSTPMFDVTRSMTSGCRQELHKTYTSTLNMSTNVFTPVSYSRFPVARIYSAAATAVQQTESTSFNHQQFSSLKGAVSDDLVTALVDRPFNLTTMTLVQEEVLSLLPALADPYDTSKKTTLHQGSRRKAVRDSGLPGDKNLRRHAELKYARETVGALIISPTRELATQIANEALRLTSCPGRPVEVRLLTGGTNKRPQMKGWMTGRQDIGGYYWSSAELHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZN6</accession>
    <name>A0A8H5BZN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZN6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="12319" checksum="562C72FFB861F4ED" modified="2022-01-19" version="1">MSLTDEEPLSSNATVALLLIAGFAFVAAIAFVVKFILHVEFTKEDIYGDRPDQLESQHRRRASYIYQFPQDATATGEMKAGTSAHAPAHVTGGRLGRDVDPKVVKLLEDAGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZZ5</accession>
    <name>A0A8H5BZZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000312">
        <property type="protein sequence ID" value="KAF5332334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZZ5"/>
    <dbReference type="OrthoDB" id="3029622at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="381" mass="42479" checksum="D7601532DE070A6A" modified="2022-01-19" version="1">MRIVFLKQRGSLQDASLWLRLRHIKAMMDFTPLKTQKMAQLSDEQFSKLRETFAESSGGTGTYGAYAVLFLMAVYVLLRNGLHNSLARQILFAIILFIFVVCTAKSVAYTKLFYMTMDDFQFSESHQVLIDRYLIVLSVLTHVNSVLSDGIVVWRAWALYPHSIKVKTFLSLCVVGTIVTSSVDCAFEIKDGSKTHTTRSGLGTLWFYLTLLGTNIAATGLVGYKYWEYRTIKGTVADASMINQARGKPKVEKVLIMVIESGFIYCFYWITVMLSAVWGTADVGHEVLECVLPQIQGIYLTILILLVAGQRDDVDSTTRGISAIEFAHSPNLGSTDSSDGIAGDSDERLPHIGQSFVERVRKSEFKSFESSLKKAESTSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0L4</accession>
    <name>A0A8H5C0L4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000295">
        <property type="protein sequence ID" value="KAF5332975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0L4"/>
    <dbReference type="OrthoDB" id="2959034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="621" mass="68671" checksum="03FF7BB627A8DE83" modified="2022-01-19" version="1">MDQGKDLEGTYIRRGIILLTRQGRVYRRENEGSRHVGKAMIIKPERFSTNLTVTDSSMVMTKTQEASSSSRVIEEAPPSYDDISADPISSGSSAFHFVRPQQASSSNSPTLRPPTTVFGSTPNAGSLPERHSSYVPQSSFRPRPPPRPYVSVFSPTSAPDARLTVHDRSLSHSPSHSQSHSPHFSPSPSHSPLFPPAVLSGTEKPPIHPSSRRHSRSEVIRSPKTPHVAPVYTPKKHGWLGGGKEREIKEAREWVIGHINDLVRQTHTYDLEACNSILGACTEACSLTPPLNLSDILQVRFIDDHTPFYWSIIHRPAKARLIPDLLVALLKFGSPISNTTRADIRHACLTLHDQELFQHLRSSRRFMPRRIPEISINGKIPIDEIRVQEIPGADAVFRVDFEIPQFLKRMYLEREVSLEFIAHRRAWHLNFKSSPSRSPAEASWDLTLSLSEFSSPTYIDSQFTILETALFPPSPGPSSATPQSPSSKPSSRSKHPKPSPSMPNLLSTNQNSQHQHRNDKENFNNPSPSRAQSPRSNSGGGTLSRADKVLSSPGPMMVRLKSSSMISPGKKDVTTSLGAGSPIGTAIRLRNSDYLSSEGTLRAKLEARLTKPEPDSSCIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2R2</accession>
    <name>A0A8H5C2R2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000302">
        <property type="protein sequence ID" value="KAF5332887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2R2"/>
    <dbReference type="OrthoDB" id="2745898at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59022" checksum="15C799D9B3140050" modified="2022-01-19" version="1">MDKPQARAAGSQSSSPTFPQEIFDQIIDWVAIAQDTIPTLKTCTLVCQAWLDYGRTHLFREMKFPLEFPKTGTEYISSHIRSPIVREQWKERVAVERSVRALKNLVMMMDSAMSESKTSLKPWSLYTRRLTISGYFPSTLLIENEMLNLLSLTFTSLEFLEIRHTNTTPKPMAERPLAGTDSDNTNTSANVNANATKSTVSLFFGLLERNSSTLQSLVLQDVIFASVFYLVECLSILMKADNATLHSLSLREVIFDSTNDGSTGTKLDGFLSNQSTFRCGNTTGLRTLNLDGASDEGSRMQRYTLLPAFFGHSKSLFDISCLRNLSMHLSREDDITTLHDILSYDHCQITHVQLKFARIYGIAALQPNHIPAFNYLESLTHLQIMFAGFYGDRDIQLLQSILQNLESLFTNLHFLSIAFTPTALTSPPWKIKMDVRRLFQKPDLKELLSGVDSCLARALPVKTRKGPGLEKVEILLSRRFKPEVEDIELVKGCLPKCSELQQLKVCFTEMVDSFWFQVAAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6Z4</accession>
    <name>A0A8H5C6Z4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_014467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6Z4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034150570" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="12">
        <location>
            <begin position="450"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="13">
        <location>
            <begin position="715"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5336289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="100223" checksum="23F65217CEE6B6D3" modified="2022-01-19" version="1">MTTSTFLRRFVALLVIAAVAPCLALIHDDSSTLHKAQYDFVVVGGGTAGLVVANRLSESPEVSVLVIEGGVSNTKDALNIQVPFFCTKATPDTPFDWNYSTTPQEALLNRSIPYRRGHVLGGSSSTNFLAYNRGPSDDWDRIAAFTGDDGWSWEKLQPYILRNEILTRSMDGHDISPQIIPSVHGHSGMNGDSLASYPTPLDNRVIRTTEELKHDFPFNHDMNSGFHLGIGWQVSTIRNGSRSSAATSYMASQYANRKNLDVVLNTKVTRVIPEANSTTFKTVEYVSTSGQKNQVTAKKEIILSAGSIGTVQVLTLSGIADPENLSQLGIESVLNNPSVGQNLSDHPIVGQSWFVNDTHTWEAAARNATIAAEQLREWKTSRTGPLTDALGNHQGWLRIQKNSSIFEQYSDPSAGPDAAHYEIIFANGLNFATPPPTGNFMTISTVVVSPSARGSVHLNASDPLGNPIINPNLLGHDFDMFVMRKAVLSARHFLTAPVWSDYVLSPLVNATTDEEIDAFIRNNTRTIFHPVGTAAMTSEHSGYGVVNPDLKIPAEIAKIAGPLVIGYILNSVLYGILLLQVYMYYMAFPKDRLVLKMLVYGCFILDTAQTVMNIADAFSIFGSGFGDMGNLRKMHLAGLSVPIITGLISCAVQNFYAYQLYILSNSRVLSLIISSVALVQCTGAVVQGVFAFKIDNLATLQSRTFIECTIWLAGSALCDIIIAVSMTLFLVKSDTGLRRTHAIIRKLIRLTIETGSATATVAFIDCVLFLTVQSYPYHTVPARCLGKLYSNTLMAILNSRMRIPGSREDPELHSTSIASPRDYHCYDDPWGTIDLNFTTMRSRRESSNRGTFSLSRTGQGRSDINTMSMSMSAGSIDVTDGIHVTKETWSRSIPVSALTSKKGTRHSVAIRESMVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9C1</accession>
    <name>A0A8H5C9C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9C1"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="621" mass="69471" checksum="6B2A05A9CDD8ABD5" modified="2022-01-19" version="1">MSDAGENTSANVQGNVPPPSSSPPSSPTLPVALSMPENTNPNYVMPLSNINKAFDSLSVLTGSENWKMCSGLHPGNTVKLACFNTITGKIDDKIMIHYIEESDAIEFIEKLKQRFNPSSTVQESNELWKLFNLCKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSACNCGCGCTTWDATTAPEGEKPVYTAVDLIVRLKKEFTNYRLSNARTYPSSSGKKSDKKSGSTSQGGAQRSDKSKGERANAAVLYQKPSDGKKDQKCFNCNKMGHMTQTCPEPWTEKSKEAMKKKGITKQSNKGKVKENASVAVSMPASSSSQVATTSTSQLDWVQSISSGDVEMEDSETPVSHHISLPAFTTISDQDHTHIIDSEHLELRLAGDMQVEVRKDNRKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLMSKSQVEGELQNKNQEPLETTEENTNETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYADNVGNPISFKDVLNHPQPRYLNDPGEEHYAAAKQCYLYLKGTCDYWLNLGSPTITSTYGFADSDGMSTYGNKPIMGYAFKFAESLISWSSKQGTLRLNYAHSHMPHKKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9L6</accession>
    <name>A0A8H5C9L6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9L6"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="110"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5337654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="554" mass="59966" checksum="EE4B1D7BD0E03FC6" modified="2022-01-19" version="1">MLPCSDTYRQRSPPRLLFPIRVFRPLKDVSGHFITIFHSFTLPVPLRAMLVPVVAATFIISALAGVSSAQSPAYNGICEQISGSISAGSGVYYKPDRLYRKGIEHFMTSSEQESSCVVEPGNTDDLGKIITILGSTRTPFAVKGGGHCSNPNGSSTEGVQIAMYRFSDVNYNANAQTVEIGTGLIWDDVYNVLIPQGVNVVGGRTSGVGVAGFTLGGGYSWLTNQYGLTVDTVVSFELVKTDGTVVTVTDSSDSDLFWALKGGLNNFGIVTKITLKTFPQGQVWGGLVIYTSNKLDEVATAVTNFAANVNDPKASIITAVNFLLTQTLVTQLIFYDGPNPPDGIFDEFLDITSLSKDVKSRDFISLFKSSPVNLTANQRGLFQNIPVVNLTANVINAMFNETKVKSTHPLFGNDLTSYLSLCSTGVTNSITTPATFISYQLEPFLPSILSHSSSASAWPPTRDVAYLPLNIDYGWLLESQDEVLRDAARQSAAHITQVALDEGQQVENAPHYVNYALYDTPIEKIYGASLDKMRSVKARVDPDDVMGLTGGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9M2</accession>
    <name>A0A8H5C9M2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000207">
        <property type="protein sequence ID" value="KAF5337772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9M2"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034947081" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="333" mass="36889" checksum="2175815D1FDA1244" modified="2022-01-19" version="1">MKLPSLLVILSIVALACSRHCTQPRQRQEWRTLNDGQKRAYLDAVVCLQSLKSNGYYDGAKSRFDDFQVTHQALTDEIHHVGQFLAWHRYFLNIWEDTLRSECGWHGSLPYWNWSIDIDAGKFDQSPIFDPHTGFGGNGADEAYPTAGFFNNLTSLPGWELSAQTGGGCVTDGPFANYTLNIGPGTLKRKHCLTRAFNPSTFGGITGQNVKDTLAQYPFETFRIKLEGFPHIAGFETHTGGHLGVGGEMGNVYSSPGDALFYAHHAMLDSIWAKWQSVNSTDRMYQISGPSSVNVNASQVTLDFVLPMTGLGDNVPVRNVMDIKGGFLCYTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCI8</accession>
    <name>A0A8H5CCI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCI8"/>
    <dbReference type="OrthoDB" id="2796893at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="511" mass="54028" checksum="CAEB565C6B1713EA" modified="2022-01-19" version="1">MAQTQAICLGGFEWMQNDAQDSPCLLAAKVIAPCSQSGAWNIPALSEGNHYNPPSTSNDTDTDCYWQVSKKKTDVFMAFADAKHSSWAAYNLLNACAACQNNSDGITSWLSFKQDCGSHVSTSTYFPPNISLAGNSSLPFYATVDPSTWQDEKFNVQQAQLPNFANQPDVNPATQAGGNSTTPQPPDTPSPKKMNVGAIAGGVVGAVVVLALSALLAFWLIRRQRKTRSEDGIGIVKPGHERSLSDMTQSTYPQPSDFPYSQMASPGPFSIHTHESDPATISRFGSIYTTPPHGNSPTRGPSPISSPSVSPSLRMSVASAPSANIGLGFQPMAVTPESPNENVIRPFIVNQHTVSQTSLPMNRKGPINLQYDSPNSPPVNRAEDYFGDAIAESASRPQMNPPAYTPYPATATDAGAGVGAGAPSDATTPTAEVVAGLRERNGHSHRPRPEQKGSFDTETPWTSTGSRVVTTATTDLGPSSGETTITTPVSPSRHVVNASVISGPDDGPEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCJ2</accession>
    <name>A0A8H5CCJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCJ2"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="107"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5339244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="851" mass="94950" checksum="A8D684EDA51F0313" modified="2022-01-19" version="1">MAKAALPQTPRRSKRFQPIVSSPRKGSRSTQAAGASWCPGARPLDTRPLDASRDLLPEEVDAWNNEEDEENRENLETRFYDSYQTRKSAHMKRKTTKGKGKTESEFVTYKVGDTIFVETEMLAKKAPSIAVITGMWETDFEAEDTERIRLGIHWFIRPNELPSIRAKRNYQENEVFYSLSNKAIIGASQVIGPCTVQKGETPEAAPSPSKSPTKGRWTREVVPDSDDEIITLPSSQFQCIYAVESRRGIFYNFDWLKHRKEALKYKPSDDEWEGGVAWDAHDGVPEAPPKKERKPATARPPPRKKVKATPTKAKPRKPAKAETEPGEEYEVGSDAESEDSGEEYDHEDEEDEDEEDVGSVVDEDELDSDEAEGTASEDDDEGMPKTPSKKRKRKTALSTPRKPRGRATVQPTPHSKAALNRRKRSKSQGSPSKSPSKKKAFPVRAQNSFKNVDSSSLRKLPEDPWARAMHVLHVGSRPDTLPCRDEEFDWLLRTVSELVEEGSGGCVYISGVPGTGKTATVHAVIRELTRMAKDNETNPFTYCEINGLRIPEPSAAYNLLWESISNHDVAKEGHLKISAKESLKALTRHFSGGNRGPGGHACVVLMDELDQLVTTKQDVVYNFFNWPTLAGESAGKNFLPYKTLQLDEIVTSRLKCVKESLKADKQKDVIAPDGIRFAAMKIASVSGDARRMLDVCRRAVELCQSLGRPARTNDVAEIIKEMQNSPTAAYLNECSLHERIMLAALIKCVKREGVEEIKWSALHNQHLDYIPALTSGSDPTRRLSVSELYMVLESLVASRAMLLEDGLAASRKDFGERRVILNLEQTEVERVLGDVGGQTWKNLLGVGHAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD44</accession>
    <name>A0A8H5CD44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000189">
        <property type="protein sequence ID" value="KAF5339039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD44"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034270960" description="Tail specific protease domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5339039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116598" checksum="F1AB147BBE9F3FB6" modified="2022-01-19" version="1">MLGLFVTVLAACYPIAAAPTATDDPCAKIAGKAFVPPADALACEKSFPFNETLRQNVLNNIARVFDFFTFEEFYLDSPPPFQESTSDIRAKLAELNSTGFETDYDFNIAVYDFTTQLNDGHTRWFPTCYTSYQNILPAPFINVEVDGTQGVFIAFDSVAFISLLGSEYTDFFDDMGFDWRRLAGAQVTEIEGQAPYDYVDFIAKTVSGNYLDHGVRVNSVFSSYRISGTNFSQRLGDLAGPTGVKQTSLNVKLIVANSTEEETLDIPFLANFLGTNFTDAQSFWTNNCAANSETNGIDFNPPSGVRPNIEPAVRRAKAFIIDKSNSSAIGLPEQFLPTIPSVDGSSGVIKNFLLPDNETGVMFVGSFSPDDFDQFQKDTVDAIDSFKAAGVTRLLIDLTNNGGGFVCLGQFLFQFLAGAQIGYPGFVSTNRANPLAQKIVAADIALGNDDTDTFYSADNFAFLNDTQMPASFDYIEPSAPFQINGKQDPTSQRFHDTCQLEFSQDVPDEGPFPPENIAIVTNGNCASTCAMFSTLMNERLGTKIAVFGGKPGENVEFKGMAGNQVLEWSDLDSEIKTARVKDDPLAPPDLLVDANMRHNWRTAWSFFNESVPIAYLSELPKFRFNYTRDTPLGNVIMSPFMLPSNLIRDLDTLQLKWTCACTYLKAARANEEVFQLPSYLRTCLCFEMSSASSSSSSFTTFDGPYDLVLETTTPLRLARSSSPRRLYNLSMDSSFSCSSSSSSMSSPSVYSVEDSPKRELESPCSLDERLGYRFIRPLPSVPASPPATSRSPKTLRPLPLPPPPSPETQLSISVSPASPTSPVTSYPPIPKRDVESPYPLLPNPHIHPPPRSSSRHRPNPFSSLSLDVSDDTLAPPAYRSRSKDTLVPAPSPSSLCVTEAPTPTTDRRRRISRLRRRLGDGVPDELIPYKYDADKTRRKSLRETQSQDDLYSMACKSTLQFGGDLESDEEDTIDAQVVKIPPLPSSRVAFSTSRKITKRRPDEGRKEEPPESAPASSLSYRPRASNRISTKWVREKGGRRWEEQDYDSLMNALRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDT8</accession>
    <name>A0A8H5CDT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDT8"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5339241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="376" mass="40861" checksum="F3D64DA3D860DD37" modified="2022-01-19" version="1">MSFHQPSPAPSQDIVPGEQYRYALTNFRIAHEKVEQQRLQLEEQERQVAQLRARIALLEGGNAPQRFGRGTNTIDDFSIKNTASQLEKMINRWASDVVRNPRPGVSLPQICQAILSDIPTGHEVGIRYEGTSMQVQALLRHAISEAISEGTINCLIVTNSSDANIQLTRIHEHIFARDPTVACVWRRQTFSAAVEQCTPSMSQAILLEQIPELIQLLDPSISASSPLSSPNPNTQSPDRAIQSIMESAYDFSRMLHGSTVTSVSGGSGGDAFYRAFVPELGSALQPRQIELVKRCLKSERGEMDRVGATIFPGLVKVTRGAGSGEGQQGQPETIQTVVRRAQVICECALGGVSDNASSASSILSSSSPLPLPHGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE72</accession>
    <name>A0A8H5CE72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE72"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="414" mass="47503" checksum="879322D42E8F27A5" modified="2022-01-19" version="1">MRLLNTVTLKLEEFYTDIPPYAILSHTWEKEEITFQDIRNLKAAKRKAGYAKIENACQRARQYDFEWIWIDSCCINKESSAELSEAINSIYQYYADAVVCYVYLSGVSAEYHPRDLKSSFSKSRWFTRGWTLQELLAPKYVVFLDEKWVKIGTRWSLRDAVSAITSIPGPVEVFGDRDIEEYSVAQRMSWAALRKTTRPEDEAYCLMGIFGISDDRSIFAWVASESPRNKERGLLARSPYEFRFSGQVKPSNSDLSGLEYASYSFGNNGLRIHLPLTRSYSVPGSSRVGNESGNSEIFLASLHCQSESNGGDISIYLQKTFRQRYVRIRADTLVIGSSESSSSRPEILQEFTVKEPPISRATREHAYIMRFNFRRLPSAQHFSIAKPLSTITLPDPYFVDRRKLKSAPLEYRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CF54</accession>
    <name>A0A8H5CF54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CF54"/>
    <dbReference type="OrthoDB" id="2909983at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="490" mass="54466" checksum="4D1D47578E53DD8E" modified="2022-01-19" version="1">MSTQSAHRDTPSVDETEVTHDQDEDDLVEVNSTVTGTLKKQFAHEYRRHGSTKERRSWIKKNTELCCTACIQANVPCIPSQDFPRCQTCKTKKRSSCSRVAQERKERLMSVLDIDETTFEALHSWYEKSSFAKSETANANGTRKPRGAAAVATASTAARNAPTNGKSTANGKKKTVPQVLSMLKLKTKVPESRPAAVNQANQVPQQSRRVMVVVDSAPAATGMVKKPKPQPPKPSSIMKPRSTTESQRNHVRAPPISEPPKIRQSSAKPPTGRNHPASQSTNSNHSSSKDRVRPIRKGSVPAIPAKFRDLDRENSEEEEEEEQGEGNDSGDDGYEEEGQRNHEDEVDYNEVNETLRIKQEMINDQVAALSPTAMTRTEQMKSFIQLHVYKRKLELGMRQVPPGSALRDTLGDVVTGLGNLASVHLDAMALGFEQGSTLPSPKSSQAGSNRRPRSQVIDDEIDEIDELPERKGPARKKFRKEVRFSRIRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGM5</accession>
    <name>A0A8H5CGM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGM5"/>
    <dbReference type="OrthoDB" id="10548038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="66875" checksum="D80CFF779C2F0B01" modified="2022-01-19" version="1">MPRTSISNAQDGYMRDPNFFFADGDCGIRFGKIEFKLHRKLVTKSRLIYRGFNEYHVNKIFTFPPPNGYVGPGADPHNLRARYGIGVKFNFTATGFPLLDIVRGKALREYQKKAAVLESKKKVAVEEDWDSSVSEENDENDENDENDENDENAMVLDQVDESDENVHVDGTDATDEAEDLEQFRAWLWAIYNHAEFRDELSELSKPTDMTRLARVALMARRLDCLSWQFTLVKKLLHHSTKSEVQQEEEEDSSDNWQPPPCYITDCSHHYLPYLLDVTMVYELNVERMKVEEKWIQRLTFKDDEHMAALKYAKDRRLDRLTALVYYEYVIRPPTTEHQHQAVLGASTNSIIPGHMSRISRGIEAIPIYWDWFTATMPSIFQGNPHDVCNGIYHRTKCVPIWKKYWVALVDAVHRHDERKLLELLGQKTSRLRLRACGRVLDVKERIAKLGCYLITYVEDEEKNYDVEYRLRKDRAMREIEAGCSSERRKQLMDNLKIRYVKGVRKECWKKSIDLVREQLHLTTGEDGRLVMFFLKDLTVTKEAFGGIEKARSVQHARYRITKPGEMVQGLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CH70</accession>
    <name>A0A8H5CH70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CH70"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="185" mass="20617" checksum="850E96F8D4BC46B4" modified="2022-01-19" version="1">MPSSEDPIAQVYNEFYPTDPNATHPPRDIMEMARRITQALEGEGVAEKPYAPILFPNSNENLTSNLPQYTRLDPTTRTEDDRIVEFDGPDGKPTLGQQRSSSIKNIYVSLKDICPEPEDLPPSLPSRRKAPTPKKTIARTTRVSGTPTTRKKTTAPPPRRLLFRLLLALLLVLLVLVPVKLQPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKM8</accession>
    <name>A0A8H5CKM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKM8"/>
    <dbReference type="OrthoDB" id="2800877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5343504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="36893" checksum="B45192C4D293EA67" modified="2022-01-19" version="1">MYWKLTDSYIGMCSLPASGKVECFEDEKPRPSITSLTAHFRKDHTDNLKLAATAASYAADPEVPKELSGASASARLLDGYIKEGVLNPTVEPMRRGFLKVFTAWLIEDDLPFTTGESPALQRVFDYLKIKWKLPSDTTVRKVLDEINEELWGNVIKELMAVSSKISYSHDVWTNRQMIFSFAGIMAYWIDDDWKIVERLIDFKHLDEKEHIGQYGVKEFYHSANNWIRCLAHVVNLVVQAILKAVDEAGCNSDEEDYYLLNKEAPFHYEESEDDELIAMEEEENVEVDEEHQDSDVSELPENARNLSAVKRASVLQLLSALPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLG9</accession>
    <name>A0A8H5CLG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLG9"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5342998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="259" mass="28214" checksum="EB20E1015D20660E" modified="2022-01-19" version="1">MKIENRTFIISGGSSGLGLATAHLFVTHKGYVSVLDVEPPPSDLPSSRVKYFKTDITSVQDIQKAVDGTVAWTNETKAPLRGVINCAGVGTASRIIDSNDEPHDPELWHFTVGVNLTGTFDLTRLALRHMVRLEPESGPDAERGVIIMVSSSAAFEGQPGQAGYAATKGAIASMTLPLSRDLARHGIRVMTIAPSLFDSKMMERLTDKARNSIEKDLVYPKRFGQPDEFAQTVKWILETLYMNGETIRLSGAGRLPAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLQ2</accession>
    <name>A0A8H5CLQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLQ2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="7148" checksum="24FFFCA0A64BA2F7" modified="2022-01-19" version="1">MITPNLEKISSMHSAHRDISYGSDSTSGSGSDPAKDDLKERMRAKAASLLPLCCLYTYRYQDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMD1</accession>
    <name>A0A8H5CMD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMD1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="280"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="708" mass="77846" checksum="34508213B8D4F3F4" modified="2022-01-19" version="1">MNGDHSPRSRPSVPQFPPPAQGDYSEYYPHQQSYPQHYGDPNHQYYDTAQQGPPQWSNPNPFVNSTPSRPPEAPHYEERSPQDNSESANKYSFSSYQHPRDIPPPPDAYSGTSNQQRPLRSALRRSVSFAVGDVEPESDDEARSPEAERAQKRRGVPSQMLDLHALNRDIEKEAEKNIMRRRQSSHSQYSDDEGHYSTARASFTNGHPDLRRADSAHSVSSDILDPDDPRVTGARAQCLDDPEDLEKNTLRQMDYHSRRKHLMRVKIEFNVSSMINRQEFLIKLARALMTFGAPSHRIESQLVAAARILEVQAEFIHLPGVIISAFGDQELGCSDTHFIKCSGRLSLGALHKVHLIYRSVVHDEISAKKATGLLEDLLNAPPLYPVFFRCFLAFCLSALICPLAFGGSFLDMWFAGIGAFVLSILNLFATRSALYANVFDSIRSQIFCYTAISSASIIGILPGYLILSSSLELASKNIVCGSVKMVYALIYTLFLGFGLQIGSDLYLLIDKPARHRLDNLSSSLASTVALTGSWLADNGTGNDTLPLVGTWTFTRASSAVAEDIIAGCYRPDHFPWYLQPFPMWTSFIIVPVFSLLSSLANLQPFKSKQLPVMVIISCASYASNKIANHYIFNRSDVVSAIGAFTVGVLGNVYSRKMGGTAFTSMVTGVLFLVPSGLSQAGGITANGNGIDIGGAMIAVTIGLQLGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRR3</accession>
    <name>A0A8H5CRR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_015732</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRR3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5346787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64430" checksum="9D908D29CFCE0462" modified="2022-01-19" version="1">MDLSSVTLPLVVALSVLLFLRRHNNRRSYSLANLPGPKSRSWWRGNFGEALNSDAWKFHEQLLKEYGQIARIDGFMGDKQLLIFDPKAMHHVLVKDATMYEGTSVTDNALIIGKGLSGITGNAHRKQRKALNPVFSIAHMRDMVPIFWEVVDKLESGLSAKFTNDRSSSQPQEIEMLSWMSRTALELIGQAGLGYSFDNLSAEAEAHPYPGIIKQLHITGGRMWFVRNYVLQWALKIGTPSFRRRVLDMIPWKDGHHMRDMSDYSWEMSKQIYDGKKKALAEGDEAVAQQVGKGKDIMGILMRLNTEEEHDSENKLDEDEVVGQMAILVFAAMDTTSGALARILYLLAAHPEVQDKLRREILEVRSENKHISYDQLVSDLPYLDAICRETLRLFPPLPHVFRYALQDTVLPLSTPITGNDGTPITELHVPKDTRIMISILNSNRNPAIWGPDALEWKPERWLSPLPNEVVEAHIPGVYSHLYGAFFSLMLTIWRLNILAFRMTFNAGRRSCIGFKFSQLEMILSMLVAEFEFSPSQKDVFWQMNSITMPALEGNRQAPQLPLIVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRR6</accession>
    <name>A0A8H5CRR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRR6"/>
    <dbReference type="OrthoDB" id="10654410at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="32906" checksum="B4671C6D7F7CFDEF" modified="2022-01-19" version="1">MDRWHLSFLLPPSLPNPSLRALSALRANTLPSFRSYSFVRFRPLGWDWYPAQAFTHHNQMPINLVHRDKENGFESLNENHLTPLIIWLASAGLVLIGVLFATVCLCKRIRKRQRVSRERKDMEAGMNKVLSFPERERESEQRSMVESMSKPGYPWGAMSTSSLLSGPVPQASVGIERQEQHHGRENVDGAMPLVQATSTSTHPEPSHIHLPVHHGLDGTQLRAEYDAQKAGKGALPTRTDVSDDSDSESFEIVEVDNDSFRSANSSIRSSSTINTVYRFHYPTLPSMPHVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTY0</accession>
    <name>A0A8H5CTY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTY0"/>
    <dbReference type="OrthoDB" id="3026831at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65019" checksum="1082C9DAAE154811" modified="2022-01-19" version="1">MADPSKSNAPSFFPHSHGFSYVKSNLYNVAGNMDVHNHSDQGRGRKRSSLFSGLLSRIGEAISWSTESPVVNRCTQRIVSQSNIELLDQLSSRRQYRIHSAKYKQRLVLVKVFQGTQAKKNFKEEKRQNQRLLHPSLLKMIGVSSFTTESPFIVYNFAPTRGSPVSELAIGLDYLSSEGARAGSSSKKSIEIFITDDDVLKIAPDFGSLLVEDSGRHEESDTDPLWGLFNDLCDKTFKQATCILYPDVRNRKVSSTIAKASSATATDVLGDTESLMSDVSSNLNFSEPKGSLSPRRELLWRESSRGSRSVHAVAKHYREFWEHLNLTVGQSYHSYAMPRKQAARPLRIVVHRCQGYRKEEITLTSDVAENAIVSHFIPSLHERCPVCKEIVEEEEFGYDGTSPTVKCSACGVWQHRSCVAKGQGDAQFVCFFCPALFNTGDPYIDGPNSISSPDIFSIYDGHFPHQDPSNSQQHPPHGQHQLHPAEADQIWRGFEMTSTEQLPVRISDQMLGGNSFSQNVGQHQLHPAEADQIWRGFEITSTEQLPVWLSDQALSGNSFSQNGMDAFLLPADYLPPYPQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU94</accession>
    <name>A0A8H5CU94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU94"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="117"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5347469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="468" mass="52775" checksum="1888870C14DDC58B" modified="2022-01-19" version="1">MKKTPGGSSSEGLFVGKSHPETFPFKSLSFGSVKHTNFAAQNSDLLRDFSLNIDIDALVTGLPNHNFSDIPDLARWLENLQYRMHGRSAGEGWRISMGSGSRALIYRFRVLMLEQTVQAMVKHRDPIFVESLVYADIIPMFETICNPIGVETDAFGICAESLRKTLESWPPGKPKPKFLYTIPYGCNPTGITATTERRKEILKLAREHDFIILEDDPYYYLYYGPADRPPSYFALEATERTENGQCEVGRVVRFDSLTMILSTGISIGWASGPEELLARIERHPIGLIKALWLKHLVLSDVSVIRFPIDSTFKAWIRSRSEHHELCNGSTPSSYLQATTLTQVIANALLSQWGYDGFNDKTRSVSSLYRQKRDIFEAAMQNHLEGLAEWQLPDAGMFFWFKLLVPDSANIDVEALRDVVRRLPGAMFWQNGNSGYVRVSFSQPTKDEADKGLKRLGSFLRKEIGSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW67</accession>
    <name>A0A8H5CW67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW67"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034203795" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="357" mass="40109" checksum="260440961B4074E1" modified="2022-01-19" version="1">MLVPVLAIAVSSLLAVTFVQAECTNPSVRKEWRTLSAAERTEWIEAVKCLGKLPNSGTFQQTVFPDDIAAYNSSGSWYDDFVYMHMDLNHRIHVTGFFLPWHRWYVQVYENTLKEKCGYTGVSPYWDWASDSADVKGSSIFDADVEISGLGGWGNLSNDAEVYDGGFSDFKLTYPVPHQLRRNFTLQPYIGLDETFFTEPYLYANESFTQSVVDHMVNNYVGDYKGFQQYMEGWEGPHGSVHLTLGGDLGGTCPDFAPSTCVGGPTFSANEPIFWFHHAMVDKVWYDWQNADPANAGIFFGGSVQMQDNITIWEQYPNGGPPYLNLSSLMPSNGLFDQPTIQDVINTTSGMLCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXH0</accession>
    <name>A0A8H5CXH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXH0"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5348397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="72" mass="7875" checksum="8274BAB0EA2C6073" modified="2022-01-19" version="1">MCCSDGGEVVVKLLMGDSDLSTPFVEIVGKVVDNSTIQKACCISLGQELDLQLVDQVINLIHEPKYFNNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYC5</accession>
    <name>A0A8H5CYC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYC5"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="55282" checksum="12C546CE637E22F2" modified="2022-01-19" version="1">MQDIKILQMNTHKSKTATFDLINEDKDSSYSDNYDIICIQEPWRDAYGNARQNYHWTMVYLYSRPVLGREVLLCSIILVNKRIPTGSWQTLEIPDTNDINIVVDVGTLEENVQALKTFMDMNGGFAWALAHNCNFALDKFIVIHFPHPRNGPTPKAPPLSLRDTTVKETESVCVLGVMLDSQLKWKVQQASALGEATSIVSALWRITWPSQGVSLKMIRRLYISVVILKMTYGLDVWYTPPHCPEGGQKRVGSVSALHGLEKVHRQALLSITGAMRSAPTDLLETHANLLPMRYLLEKICYRSLIRIFSLPDNHPIRKMASNAYQHRNTTTHSPPLQTLSRLFDPPAPSDVETITPLAHPPDYDVLFSCDIPPDKDQVYTREENNRRRINIYSDGSRIDSHAGAAAVLLDKQNPANNQVLQHQLSALKLHTTYEAEGIGVVLRLALLQNCLHTNQDNTNMIGLDSKSFIEATFNFKHRPRQYIIDEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0S0</accession>
    <name>A0A8H5D0S0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0S0"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="555"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="908" mass="99522" checksum="ECC6766DAA94C37C" modified="2022-01-19" version="1">MQPSHYDIQREVEALRDIRRRSTAPGALAIDPDLPAQSSSSSNPYWSGDDSSSNEEGSSTTSHASDSTADTDDPFHLFWVPASVHPEIAPAEFRAFLKEHSRSPPPGDGPAPTRSSSLSVSSGLGRKRSMLSRQYSPSENDGVGETEEKIVPLRRNRTGRFANQGPQLTINDLQKLEELAEEASETNDPTKFRNILRRSLSLNMSPTAMDQLDAMPEMEDEADVPIIARPPGQILRRAARTRIRKPGLPGDGGGHRFSSTRRGSTARAGTLPSRTSSDRSSSDHGHTESTEYVPQRQRTLSDDFHSTRPDSFSMEASIFDAYAHDEEEHQPPTVITSAPSEAKLVDEPSSILQLPTHEHQPSLFDALSPVLELPSQEPEPEPPLPQQHVPPQQPPLEPEPQLHQPQPQRLLTPQDAAPELPSPSRTPSPSSAEGAQGTSPTPSFLSSPPSPQLPVSQPTRKEKDKKGLFKWGSSDKSSKKHKDKDHTRADSGDKEKEKEKESGFFGSLFGGNRKNKDSDNAPPVAVSSGNAGREAAQALLGASKSSKNYQPPPSPGAAAINNYSRYPIHVERAIYRLSHIKLANPRRPLYEQVLISNLMFWYLGVINKAQNPSPTPNGQAGVGAGGGQGQGQAQGQAQGPGQVPGEGQANGAQEKEQKEKEQREAELREKERLEKEVREKEQREREQEMKKREVSPKRGSLTKAGPGGARRAEIAVKGPQYEMQHREMQQEYGYGGGYNAQPPQGMPKGRGPTSPPPGSGQRTGYQSQSSAPVNSIPPRLVQPPDSQTPDHLYYSTDMAHQQSQPQAQRLPPGAMPPADHSNWGSQRQSPPLALIVVQSHRLSKSMEEGGHQGGHYRLRRHLHPRWLMGCLGKGQVHMQSQQKVDHNRLKMTRMCLWLSGSKGGDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0U1</accession>
    <name>A0A8H5D0U1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0U1"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="25"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5351501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="319" mass="34415" checksum="7379A2DB9CED912C" modified="2022-01-19" version="1">MVLLNSISIAPPFLNSSCAWASDLDQLRELYQSPYTGAVTTRTSTPNGFKEDPSIHTVAFDENTSINSYGYSPYPLSQYLNLIKSILDERENPTKPFIVSITTSIPADLSVMLARIQDLRKSYPHLIAVELNSSCPNIPGSPPTAYVPSSLPPLLAVMSEAYLKDPTLTLGIKLPPYVYEDQFHQLLHVLKEYSYTTPDEKETNPFSFLTCTNTLGNSLLFEASAETGATPSFALPTPLGGLAGEAIHSLSLGNVYTFKKVLSTHASLSHIKIIGVGGVTTPQAARRMFEAGADAVACATLLGRMGVKAFEVISDGVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D211</accession>
    <name>A0A8H5D211_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D211"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="149" mass="17083" checksum="80F11B843AC05F80" modified="2022-01-19" version="1">MIFTHIYKPCPDTWFPISTSSSLGPAYKLLECLETTWNYKQGNPMRLEVKNTRACFTFANPDDAVSFYLNPGILKNWTRSWGIEPPDLSHVAAMKLGATKALCTDGFKDKQISLIHLHDLFSVFGKAPTNYIMITEKPVFNHNWYLIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3H8</accession>
    <name>A0A8H5D3H8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3H8"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5351517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="197" mass="21938" checksum="6EE5E884D72CCFF6" modified="2022-01-19" version="1">MRPLVLSGPSGVGKSTLLQRLFAEYPDKFGFSVSHTTRAPRPGEIDGKQYHFVARDRFLQLLGEGAFIEHAEFSGNFYGTSFQTVREVEQQGRRCILDIEAQGVRQIKATNLNPVYCFISPPSLSSLRERLTQRGTETEGSVKKRLATALKEIAFAKEPNVHDIVIVNDDLDRAYELFKKVALGEKVAGDALPPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3J0</accession>
    <name>A0A8H5D3J0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3J0"/>
    <dbReference type="OrthoDB" id="3261349at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5352970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="41025" checksum="12FD739B8EAC6417" modified="2022-01-19" version="1">MVSRTGQDPDSINGQRVANYLHLAGFVLLFWDHALTLSLEVKYLWKLSARITTALFLFNRYFALLTNVIVTVSFFDLSLTTSRFVPAIIDKHIIDSAFSCGVLFIFREISYVLIEVNVSILLTLRIYAIYECKNWVLASMLSFGAVLAGLAVYALFSTPSAGVTSSISLTPLGCHTMLDLVPQAVQGAAAWEALFVYDCLLFIMVVLRRYRKRKSLGFGRMPLLEMVIRDGAIYFAVMALANLANIFTFYFAGPFTRGSLSTIACCISVVLISRLTFKLRANADADVEVQVQSGSRTRGGTGIGIQRLRGEDAIPMSTLCFVDEREYGDGGGGDDGDGDGHSGDRDGHEKSDSETDRLRSTSHDRHDHVRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5H0</accession>
    <name>A0A8H5D5H0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5H0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="14673" checksum="17C464463D606936" modified="2022-01-19" version="1">MFIIRDYRTFDFKEKDEVDKHYPQFYHKTDKAIPSTSNASASSTSKSSMPAQPNPPTPTSLRLRIRSLPHHPSPLSIPPSVTPSPPPVPFSTSPTSLSPSSLSTVKSGNTSNKLPTGVYGKVLYRQRNSGVFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ERQ7</accession>
    <name>A0A8H5ERQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000620">
        <property type="protein sequence ID" value="KAF5309688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ERQ7"/>
    <dbReference type="OrthoDB" id="2671065at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="40"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5309688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="670" mass="74776" checksum="E457EA35993094BC" modified="2022-01-19" version="1">MLVHNLLGQRQIWLEAMQWLETHRFMPYIVSLLDIPWEHKLLELKYGWTFNLAQYLSDDWLNDCHINQMVAYLRTQLPHNHVILEDADWSHTLIAAYEKRERVAEPLAGYSGLHDLAEHMRGGSVPKMKLAFPIFVATASSGSKLPLRGMEGNHWVSVGIDLNKSIILYGDSLGKQSPKQLTDVLDWFLSQVFGNRAFTFGSLPCGTQSDSTSCALYALEAIAHFAMPQQFPINENLNPVVTRKRWFENATALQPAATSSAVTVKTKPLVPTAKKSAIKNQVRLRDNKPSKEIHPLFQPQPTHNTEPSKDASSKPKRKILDVEAGDDDEDKSNQDNDEEKDGDLGNVAKPGELIPLHSRNAPKSTGAPKKKLLDDLTWPCYKPSDPAKILHKCIAKHLPTDLKDQAKAQAKLKAPSARLEELSGTAGGVTNGEEAGETKEEPASKKPKMMQEFTNRGSKAKQKVRHAQLDLDCTILFSTLPSNLANSIHFKNLLNHADPTYEVPTREKLDEELTPGEAENVLAKQLELLKNDHFLTVSFDGGTKKGESHYTLHISNPERDIYLMETRNATDESHTGEWIKVLAMKWINEVGPARFAASCSDSTGNTLLARHLIVDAVPTILSIADCCHHLDNMNKDIVKLTYFQEPITVIRGTIKSFSQSHVGKSELEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8T5</accession>
    <name>A0A8H5F8T5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000380">
        <property type="protein sequence ID" value="KAF5327956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F8T5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="79" mass="8893" checksum="C81380050AF6D79B" modified="2022-01-19" version="1">MSPTETKSMSVHSTASPRQPSKFPPALLLIANFTRLAPEFDRPRIDLHNITVMPVLIVHGSNIFRHDELRLRCPKGGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC14</accession>
    <name>A0A8H5FC14_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000327">
        <property type="protein sequence ID" value="KAF5331319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC14"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034201901" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5331319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="29428" checksum="42D3280CB05D8E5C" modified="2022-01-19" version="1">MFGLIRLFSFFVIFEGIVAMVSPYQNQTESHHFQAPGEGDVRSPCPFLNVLANHGYVPRSGKNVTIPDIVKGGREGFNVGPNFFRLTGKYGLLTSPNIDSFNLDDLNLRGYIEMDTFLTRPDAFFAPNNTNLPFNETVYQTMASSNPGVDYYNVTSQAQVQDARLNHSIANNPELVNDATSLFARSAASALILSILGDPKTGVAKKSVVDTLMREERMPDGWKRPEDVIDVDTIRPLTQAIMDVSNWPGPNNGTYPGAQQLVIFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC68</accession>
    <name>A0A8H5FC68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000325">
        <property type="protein sequence ID" value="KAF5331469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC68"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5331469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="718" mass="80895" checksum="534D66497A39537D" modified="2022-01-19" version="1">MGHLITLATSLNQWALDFQGNMERILASIAIAKSRGATLRVGPELEITGYGCLDHFLEGDTVLHSWEVLAKILASEEAMGIVCDIGMPVVHKNTIYNCRVIIHNRKILLIRPKMWMANDGNYRELRYFTPWLKHRQWEDFFLPRIIQAVTKQTKVPFGDAVISTADTCIGVELCEELFTPASPHILMGLDGVEIFTNSSGSHHELRKLFTRIELIKEATLKLGGVYLYANQQGCDGDRLYYDGCAMIAVNGRIVAQGSQFSLNDVEVVTATIDIEDVRSHRAKSSRSMQAAQAEKYYRVEVPFSLSHGKFEEVREEDMIGFLATQTLEVRYHRPEEEIALGPACWLWDYLRRSRAQGYFIPLSGGIDSCATAVIVYSMCRLVAEAARRADKQVIADARRIIGEPEDSGYIPSDPREFASRIFHTCYMGTENSSADTRNRAKFLSQSIGSYHVDLNMDSVVSAVVNLFSFVTGVKPQFRVHGGSHAENLALQNIQARLRMVLSYMFAQLLPWVRGRSGGLLVLGSANVDESLRGYLTKYDCSSADINPIGGISKTDLKKFIAYAETSFDLPILRSFLDAVPTAELEPITENYVQADEADMGMTYDELSAFGRLRKVEKCGPYSTFTKLVHEWGSFLSPLQIAEKVKLFFYEHARNRHKMTTLTPSYHAESYSPDDNRFDLRPFLYPSRFPWQFKKIDEVAAALPDRSYIGTGMDKPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FD05</accession>
    <name>A0A8H5FD05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000312">
        <property type="protein sequence ID" value="KAF5332324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FD05"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5332324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="29855" checksum="F4B611F043C99EDC" modified="2022-01-19" version="1">MNYRSGQGFLDLLSRLVGTETEKFPDDIRMVPNPVWDVMNSSAKGPLLPGQRVAQRNCDTMRTALLTAFVWHTLLAFYGEIDTNKVPMKLKDTTGNSDFVKEAWRRAQREASPALAAQLKEARKKTKEEVKEYRRTAQRRMPNQGLEARQATTQEDMRQQIGSRRQLHGTLTGSPEHLTLLTVGLPEPGFTRSLYLLYQLKTLDKNPDYDYLLVRSKPEFQTDRALIFPPEMATVKILLRNNLRVAVCRYAPKDTDVPCGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJM6</accession>
    <name>A0A8H5FJM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJM6"/>
    <dbReference type="OrthoDB" id="2792702at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="170"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36328" checksum="6215762F20B81AAB" modified="2022-01-19" version="1">MSENATTISIDGAGLDMSGVFASVYWGFVISLFCGGITIVQAWLYFPHPRDKPLVQFTAAFMLILDLASSALVAQSLYYYLIPHFGSEAQLGKLTPELSSDCLMSATITFISQMWFVFQIYQFNRTTTLAWISMGLITLGALITYAAGIAILSDRNTSFIILFGIAKGTAAVTDIIATAAMCFLLTEQKTSVAQTNNIIKWLVRLLINRGLLVTIVQCILFPEIPVIALKVLFSRLAIHATTAKLYANTFFAMLNGREWLKKQHQQGAHTMSSVVFSKIGNSSTVVSSISAFHARSNPSQTDVESQFNDKSCEMTGPMGTTGFSKTVVVEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FM77</accession>
    <name>A0A8H5FM77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FM77"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="413" mass="47444" checksum="3344441B2F4BFDA0" modified="2022-01-19" version="1">MATTPTRILSPQPSPSKRLASQIDSFSIESPTKKSKLTAKLELIDDRRRSTSPKSLGDEEEAHEEEDNLEVLRTKFVGEVDLPESEEPLLQETKRRFVLFPIQYPEIWQMYKKAEASFWTAEEMDLSKDLHDWNNRMNDNERHFISHVLAFFAASDGIVNENLVERFSNEVQAAEARCFYGFQIMMENIHSETYSLLIDTYIKDPAQREYLFDAVETIPCIKRKADWALTWISDQRSTFAERLVAFAAVEGIFFSGSFAAIFWMKKRGLMPGLTFSNELISRDEGMHTDFACLLFSHLKRRPHPDVVKHIITDAVAIEQEFLTDALPVSLIGMNAKLMCQYIEFVADRLLVALGNEKHYNVTNPFDFMDMISLQGKTNFFEKRVSDYSKAGINHSTTTETSTNSKAFSIDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNU1</accession>
    <name>A0A8H5FNU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNU1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5343228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16166" checksum="4E544BE310B49327" modified="2022-01-19" version="1">MSAMAVVPLEFVKDAMAKGDFIPSVASRSLEKLASEPSQRQLEAEKVLQAGLVYAGGADSTAPTLGTFIHGLVKNPDAMRKGQIAVDERTGGGRLADFSDFGSIPYVDALLRETLRWIPLTPLSVPHRSVEDDEYNGYYIPGGATVVGNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP55</accession>
    <name>A0A8H5FP55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP55"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034363541" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="22111" checksum="528459186AE6D474" modified="2022-01-19" version="1">MLSKISVVSLLTSGAFAAVYINSPTESIGMTGGQTAKISWIDQGSGPSLADFGDAKIGIYTGNSKQQILLQTISDRINVAKSSSLQFTPDAGIGPNGNNYFVRFDSLTLKDSANPQSPAMAFSSRFTMSGMSGTFNASVQSLINGQSTAPIGGTSTATAPSMTSGIPTTSASSNHTATGSGARASSTARVNNSASSMGATVASFLVAVLAGVIAVSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPB7</accession>
    <name>A0A8H5FPB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPB7"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="176"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="578"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5343753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="751" mass="83614" checksum="8FDCFA1E43BD1943" modified="2022-01-19" version="1">MGPDLSVPYTSKVVRHSEQRPPGRIMIADCPPSSRSSLSSLSSDSPSPTISPRKPRRFSKKIVLTSDEESEESVELQKDSEGNESDVFGTEVDNPGVEEKSSVKWVGIGSDEDDDESELESVDTNPSLADLCDNGTIRSLDDELASGEDAVVKGFKEGYKLLHHQAIGRRWMQRREDPVTEKTGGILADDMGLGKTIQILARIAEGEASKDDLEAGWAGATLVVCPLALVRQWALEVQRITEHLVTTTHQSSTRTSDPEVLQTANIVITTYDVIRAEYNAFQASSSRGANARRSQVGSDSDEESFSSNKHPRVKSKKDALFRVKWFRIVLDEAHTIKNWKTKSAIACCALEANFRWALTGTPMQNDVTELFSLFKFLRISPIGSWECFNDRIAKPIQNGQGTVLQQIMLRRLKDDTLNGEPLVKLPARNLHVVSCHFSPFELQFYNRLKARMEHAKDRLIAVAADSGKSANYMTVRLMLLRLRQACDHPSLVIGDYRDDLQGSHSTGSKEISDEVIDEDNLVGAFKNLTATPRCTICGTHNVPEKNGANTICLDCSPLANLIRQQNHGRLGTSAKIRKILELLAQVEKNSQGRDKTIIFSQFISMLDLIQSFLTPEGINFVRYDGAMKLQEREKAIEAMNANDKVKVILISFKAGSTGLNLTACNNVILVDLWWNPALEDQAFDRAHRLGQTKDVNIYKLKIDGTVEERILELQETKRNLTLTALSGEDKSQDVHLGVTELLGLFRSYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQU9</accession>
    <name>A0A8H5FQU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQU9"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5345328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="15921" checksum="8D9E7172C4A9DD2E" modified="2022-01-19" version="1">MPDTPLTPGTDPKAANRARFELELEFVQALANPFYIHSLAQQNILEQPSFINFLKYLLYWKEKDYARFVHYPHALHHLELLQHAEFRAIMKKDEFFREYLHQQQFDHWRTWRDPAHLNASGVDSDVPEAKSQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQY4</accession>
    <name>A0A8H5FQY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQY4"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="575" mass="63655" checksum="5CE17928036756EC" modified="2022-01-19" version="1">MTIDLDDSNQSVFFISCAESDDEEQEQEQQESSSTPYGDLPNGGELRWEAYRAAWAKCLERVQAIVQALYEPAVKQVVKTINNAYVDTLPGIPHEELPMVVVSGMSCAGLAETLAQQGVQFTDPSNITLLSAIIAALTQEQEQREEETAPPPFITHLSPSECPNITTAMRNLISGFIVQSTGEKYTSSARSLAPYDIQVLKAWYNFATTGTQSEEDLEPEPASHTRNHSRSRKSKGKAESRNDDSSNDNGQSKPKSQCKRKRKLLIVLRDFEQFDPNVISDIIYICSLHIPALPLVFLVSLSSPSTSTSSLLKASQGATSTSTSLQISSQSYLHTTYPRSTLSLLRLHQFGPGLGPSGVGVGGGGIGVPLGRRLLGEIFEKTFIDLVYDPLLVLGPTVLEFLLDYCMKWNCDVDSILNILQSRRVYALLDFPRLFLRLILAHLKHFTTSAPTTTPTVLFLSTPPSSTWKNPASFEFLDTLMGRLHDDADVDTHPQSTPTPQPEPWDISNITSLTKSIDKLRESFYDSHRHLKLGFRVLRLVDGFLVGGGIRGCGRIGKEDWRRARGRDMMVMGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR20</accession>
    <name>A0A8H5FR20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_013077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR20"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18785">
        <property type="entry name" value="SF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="221"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5345687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="613" mass="68245" checksum="DF41B59CA70934FD" modified="2022-01-19" version="1">MSNKIRKLVEEKTGKKLCWWQIKTALAIYDGKDVVGVARTGAGKTMSFWIALMMSRAEGCDDVTVVVTPLNLLGKQNAIQLNDGSFLSAIAVSKENSNAQTYKDIASAKYNVVVSSPELLNEDLCQTLIKNPKFAAKIMYFVFDKAHCISQWGKTFRDQYLYVGIIRHLLPCTAKTIPFHIASATLPKTILDDVVDLLLLRPKSMEHVTMSNDRPNVDVVDGDPPLLKFVVFLDNTRHAEDAVKALRELLPSCHHDKIHYFHATMTSMYRDENLEAFQKGEVWGLVVTDTFGMGIDLPDIQIVVQYCATCDFNMLWQRFGRAGHGPDSSAIAVFLVEKTFFDADRLKKQDNRMKKTKAATSTETKENTGPFSSSKRKAKAQGGSLPKRWRVHNASNLEIPSPDQAADLTPSTMPIVPASVGDYAQTDESRHLMYQAKLATGARTRRSKGKQDEPIPIGSALDEFINAPTRGISCRRHVVTLYYSNDRVNNNYHLLCDEHNPAGCARCRPKNPECCCDLCSPNAFSEIPAVSPACSTHGTGKIRVSKYELNEAHATLRSALEEWRLQVAPQALGSLFSHWGTQLFLSNQMLDRIVDCAASKKLTSLSALRIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRN7</accession>
    <name>A0A8H5FRN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRN7"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="86" mass="9192" checksum="4CF6BB4D064D8E03" modified="2022-01-19" version="1">MRSAIPGLLATLAAATLLGIVSFCVPYFKSERPFTHGENGTITFGTLGFCVELVNGTMCSKNLGLGISWAEVKQLVGNHNPHFQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRP1</accession>
    <name>A0A8H5FRP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRP1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="512" mass="55814" checksum="7B889BF4BAFF1BE0" modified="2022-01-19" version="1">MSLFVDTEASAARNEGEDEDSSQEHMDNFIQEASEEEEEADENDHSGAWYEDEDAHNPDDLQSLDDNHVWAGFLRRNKQRAQQIQRPLDSDELSDHLLHLSLLRARIPGSEYDLIHGLYETFVPPNDTPSPTSTPQVPIPENTRMTQSPASTLHDIRMSSPPPSLAQQQIHEVETRESRFRQGFQACRNSLQSAAKLPEVHGQLKTILGQFYVPSEWDAAVSSVSVEDSADIDAARRKLDDLEKAWLAQGPSTASSTSSSSSPPPPSQAQGPSTVSSTSSSSPPPPSMDSWEFWGTVYNSRDMAMMGKGFSRNDDQVVEVFQFPAASAPAISSFGRVAPWFSSSSSACLPIPPPTVEPLADSLPLEPSVVACTELEASVAVSTKIPINVDALPDCEPLFLSPVGNEIKEEANPPWLNQSIITPSFHSPSRSSSPGLTFDPENEEFPWPLPSTDTPISKPTSLPHPIPPKAALAPTTFSPPRTKNSPSKTKTSKPTPSTINPNPKLLDTRNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRT1</accession>
    <name>A0A8H5FRT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycoside hydrolase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRT1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034965167" description="Glycoside hydrolase family 31 protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="308"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="758"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5346407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="106947" checksum="A793A9D0317901B3" modified="2022-01-19" version="1">MILSLAILWLAMSIIAQGLAAPNFSQNVSICPGYTLENVRETNSGLTASLSLAGPACNAFGTDISNLTIDVTYESTSRLHVNIYDSAEKQFRIPEEVISRPPSPSVSFINSSDLAFNYDPSPFAFWITRRSEPGAAPLFDTRIQSLPPAPVTPLTPNGTVINLDGFPLVFEDQFLQLTSALPFNTNIYGLGEAVASSGFRRDVGTGPTGGTVQTMWARNIADPIDGNMYGSHPFYLEHRFNSTTGTSQSHGVFLMSSAGSDILLLTPSKSNVSLIQYRIIGGILDFYFFAGPTPQSVVEQYGALIGLPAWVPAWGFGFHLCRWGYSDINETMAQVRNMRAADIPLEVMWNDIDLYHALRDFTSDPINFPAEEVRSFIQELALNDQKCLENHHLSKANCSHLDFFLDIAIVDAALPKQINTSDLYNPYIKGAELDVFMRNPDGSEYIGQVWPGYTVFPDWFRNTTQRWWTEALQNWSLSGIEYSGIWLDMNEIASFCTGSCGTGADLSNTSVPHIFPGNPGNPVVDYPECYDPLIWGPSGNLTINGTLTFGCNNFTTTAPSPSLTKRGGGGGDIDVNSPPYAIHNGFGPLSNMTLATNATHGGGVVELDVHNMWGMMEEKATHLALQQIHPGKRPFIIARSTFPSTGKWAGHWLGDNFSRWQYLRFSISGVLQFQMFQIPLVGADACGFYGNTDEELCSRWMQLAAFTPFYRNHNERGAISQEPYRWDSVANATRTAIATRYSLLPYWYSLFANSSTTGTPPVRALFFEFPDEPELFAIDTQFLIGRDILVTPVLTPNVSTVDGILPGRGQVIWRDFYTHAIVSPTNDNSTVALSAPLGHINVHIRDGSILLLHAQPAYTIEKTRQGPFSLLCSLAANGQAFGSAYIDDGISDPPGENTTITFSVGDNTLHIGAVGSFNVSQVVESITVLGVTKQPESVSIQGENNTSWEFLPDLQKLVMNVTVDMNAPQVIQWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSS7</accession>
    <name>A0A8H5FSS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSS7"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5348340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32305" checksum="82B76D581E87A6CF" modified="2022-01-19" version="1">MSPPPGVKGKESGTARVLGSGASGIAELLVFHPVDTVAKRLMSNKAKVSFSALSPIIFRDYASASVGRKLVSLFPGLGYAAGYKVAQRIYKFGGQPWFHDLINQHFKQNFTNAFGERKGKLMMQATAGSLTGIGEVVLLPLDVLKIKRQVNPEAFRGRGVFRIFAEEGTALYRGWGWTMARNAPGSFALFGASAVTKDYVLGISDYSKATWTQNFIASIAGAVASITVAAPLDVVKTRIQNANFEQKVPGVVVIRDLIKNEGMSAFFKGLTPKILVVGPKLVFSYTLAQSLIPFFGQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTX1</accession>
    <name>A0A8H5FTX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTX1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="30367" checksum="D3D9072B31B2723B" modified="2022-01-19" version="1">MILLSPTPPDGSRHHGAVAFQRLPAVSVPCVSSNISCESSSVLASTSSRERSPSRTATSTLPKPGSAKYNAMSGVTFRPGSPVKTDRQFSFGSHDEEGDIADNEVTDRTDTKRSRKPTKKMLETAVIEISTESESEQVRKKSKSKKRMPKSSGKTRGSTKSSYDLDLSTHPTSNDTVDPAPSGRKHQRSATKRKGDITGVSELPQRRSTRLRLAEDSKVNDPSETLEYVDTPELRQLSPSLQSPKGPTASNPAQGSTNEDHTLESIADGSIEYFFSSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV12</accession>
    <name>A0A8H5FV12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_010179</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV12"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034370329" description="ABC transporter domain-containing protein" evidence="14">
        <location>
            <begin position="22"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="378"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="668"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5349768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1069" mass="117772" checksum="C4EA038EE9AFB3E8" modified="2022-01-19" version="1">MLPNSLIALFLLSSSSLTVTARRTSSWPPTQSLNTYELQSGLGVSRLEKCPPCFNCMLPAFTCGQFAECDEYNGQCRCPPGWSGIDCLTPQCDSLADGEHRKPREDGDTCDCKDGWGGINCNVCKTDDACKGFPILGQKPDPDDTEAQNMTCYKGGETVFNNHQMCDVTNRKILDTVGSNRPVQVTFGCDKNSSECTFQFWVDEIESFYCALDECESSTKPDYGFNTTTYQCDKLKCKCVPGRFICGEDGSVDISDFLTEEIKGPASFSCRTGKECRFEEAAMNQLISDIFGDPYITLDCFGGECLHYSQVPGYVQPEKPDNSRWVALSVAGAFLVVIIASLLFWYVGRSGSGGDFGTIRLPEDEAARLMTEHVPASLHFSNITYNLGGKTILSDISGCAKPGQVMAIMGASGAGKSTLLDILARKGKRGSVGGVTLVNGREVKDEEFRAVTGFVDQEDTLMSTLTVYETILYSALLRLPREMSFAAKRYRTLETMNELGILRIKDMRIGESGNRSISGGEKRRVSIACELVTSPSILFLDEPTSGLDAFNAYNVVESLVTLARDYNRTVIFTIHQPRSNIVALFDQLLVLAMGKTIYSGEFSKCQRYFEEIGRPCPPGFNIADYLIDLTVQAGMGSSSRSATPTIGPSPNDDTNLADEERALVGRATHTQSVPLETVRSHSTPTPPEPSSSNDETRRSSISSATGAYIKRKTSQLFDAVSGTSQRSNDTPLAPRLAALVDAYEQSNIAAEIKAETKALVREVQGQANGNGHAQTRDVMEETALLRGRKRASWATQFRILSGRAFKNLYRDPALLTAHYTSAIALALICGFFFRDVKNDIAGFQNRLGLFFFTLALFGFSCLSSLGLFANERILFMRERSNGYYSTFTYFSSKILFDILPLRIVPPLIFGGIVYGLAGLVPTVVAFWKFILVLVLFNLATATVVLWLSIAFANTSVASLVGTLIMLYNLLFTGLLINRESVKTPFRFLHTISFFHAAFEALAVNELRYLTLKELRYGVELDVPAATILSIFGLRVQSFWWPNIALLGIFIAVFTIASYLTLHFFVKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVR4</accession>
    <name>A0A8H5FVR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVR4"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5351565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="576" mass="61993" checksum="5FAB3C2211C14F8B" modified="2022-01-19" version="1">MVLISSKKYACETCIKGHRSSSCQHTDRPLYEIKKKGRPVTQCEHCRELRKTKQVHVKCICQKADGAGNTASTSGKQGVSKMLESAAFPNGLPEALEASVALQLLSEGTSSDSDHVGCTCKTNGECHCCTPRKSAPKSRKKSPPKPSTSDASPLPGPEFQATESSSHVLNRIAELRPVLPKPAISFPDGPLHDPSSSGQVSSRHHPLEYYSPYGRAYDNIHPHGHSHAYQQSHPQLPLDLPNYPSADSIPHDSRDPEYLPTQTNLSFVSPIEPSQPSDQGSNTAENDVWNVFQQYGVLCGCGDACACPNCLTHRGANVPVSTPNNTPTNSPSHGYRSPCVNPDSCGACLECLMFSSFPGLAPPNASDVGNDSSTTSDIDQWLASLPQSALDSITSGPITPFQLLPPLDERMQSQRDVRDCRCPPGLCQCSDCGSDCQSSVLSAQGSSERQVSPPYSATSYQYPMNDSLYNAYNPSIPQLRMDFSQAQASWEAVDTTNDFDFFNTPSSQSLDPMMAMKRTRSASSSSSEASDHSHFSGPKSASPAFSDGPVSGHSSQESLHAQSMGYNQGMGIADFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWN2</accession>
    <name>A0A8H5FWN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWN2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="69"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5351538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="40443" checksum="B16F6F6F4F90B5CF" modified="2022-01-19" version="1">MLEKGFKPERTVVLAFGYDEEARGHYGAKQLGIKMEEVYGQGAFAFIVDEGAPEGFSDIYGTSFALPGIAEKGGIDVRIDVASPGGHSSVPPPHTTIGMLSKLVVEIEDHPYEAELTRDSVLYSLLQCHAAHGSSIEPRLRRLIHRSSHSNHALHKLQEVVFEEPTSKALAGTTTAVDLVSGGVKTNALPEQAYAVVNHRIDTKSSVEEVTRRDTHTIKKWVEKFNLSLNAFGEEVTDSSKAYYGSVVLSDAFGNLAPAPVTPTSGDEAKPYELLSGTIRGTFAAFRGQSLEERGIAVAPGMPSGNTDTRYYWGLSDHIFRYNHQNMKLSKSLLANGIHTVNEKIEVEALYEMIWFFSALILNTDEATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZH8</accession>
    <name>A0A8H5FZH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZH8"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="350" mass="37569" checksum="B9E999D8A874C6B4" modified="2022-01-19" version="1">MAPVRNAKVLFNQPLAGLPEPGKTTIYDTSNIIDLDMVPLNGGVLVKVLSISVEPLTAGLMMGPNKPASIPFPSYQEGQPTFSFGVGKVLRSENEGFQKGDYVVSPVLEHAEYTIPTDLNFLQKIVPEPGLPPSVYIGAAGMPGQTAFYGWKEYSKAKKGETLFVSTAAGPVGSMVLQLAKREGMKVIASAGTDEKVKLAKSLGADVAFNYKTTSIEEVLQKEGPIDVYWDNVSGSTLDAALGNAALHARFIGCGFISQLVDRTGNGVNMKNLANIVMRGINVSGFLANDAFLLEHWEKEFNDTIPKLLAKGELKYIEDRTMGLEHVTVGLAEVMAGKSMGKKIVVVSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZI8</accession>
    <name>A0A8H5FZI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZI8"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5354552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25107" checksum="F54A92847EFFBC1B" modified="2022-01-19" version="1">MAKQNSSNSTWDPILLISQIVSIQTLHYLALSIFIPPLLSFFAEPLSLEYAGGASNVGMVMDWREMAGRPTIRGIHDSEKWGSQSWAWSGGKIVGFTWREEQLKAGAPVDPIRGWIIAFCWLLACSADIYYLYILVRRPRMILDFALTLVFNHLVLTTYYSASVPTSLFFWVVVGAGAAMTVIITEQLCVKREMNEGLTLPAHVQAEEDMEDMEMGELLPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2W0</accession>
    <name>A0A8H5G2W0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2W0"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55910" checksum="2FBF8E93ADD44591" modified="2022-01-19" version="1">MSTETKVNTYDDAEKGTQEITPPPLTYLPTVYPEISEKKPIDTLMSLEDKKEVAAPPVKKSPPKPKKKVSKWIRWVLWFNTYRKFFTLTFTLNMVALALAASGHFPYAVKYNGAFVVGNFNFAILMRNEIFGRILYWFVNTFFAKWTPLWWRLGCTSVLQHLGGIHSGCALSGVIWLLFKVVRMFLTLEVEHDAVLILGVCTNVAVIISALSAIPWVRNTHHKYECHFFATRVKFSHKSIFSVFERHHRFVGWTGLFCTWAFVILGDIYDPTTKTWNLDGVHVIRQQDFWFTIGMTVFIALPWICVREVPVDIELPSPKVAIIRFERGMQQGLLGRISRSSIMEYHAFGIISEGKHAKYHYMIAGVQGDFTRRLVNDPPKTLWTRQVKFAGVSNTSTLYHRGIRICTGTGIGAALSTCLQSPNWFLIWIGSDQEKTFGPTISGLIHRHVGPERLILWDIVFITSNYIGNTEIMQGCKEAGIPVFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G345</accession>
    <name>A0A8H5G345_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G345"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="882" mass="99585" checksum="6109B807627D1665" modified="2022-01-19" version="1">MFLTGPGGTGKTHVVKSVKEVMMLYGMDHRIRFLAPTGRAASLIDGTTIHKGLGIQIKSKDKGKGNRKLGESEEDYSVCINVKKREQLRAEWKDVVLVFLDEISMLDVGLFAEIDTALRFATENYDEYFSGIFLVAAGDFNQLPPVAGCPLYMPIRSKPTASSQNEIERRMGRMAWKRLNAVINLTEQKRMALDPEYGSAVLRLRNRECTEDDVTLFNSRRIKSWNHLSGLELARPEHYEASAIVATNLKRQVLNQCKTEAICSAPSGPSLIECVAYDEIVEIGSKHAKNEPEPKLTIKDAEEPGFHMRTELIKLNFSSQQSRILPGSVQLYVGMPVILKSYNLCTELGVTNGSIGYVRHIQLEKCRSGFSYATAVLIEFPESSVNIPGLPDKWFPIVPQSSTFTVTLKDENGQHRRIKCFRKQLPLQPAFTVTGHFAQGQTLAVVLCTFKDGPAAAYVSASRATQRSGLFLLEEVTLNDLNRPKLPHELRLGYQRLDALEHNTLVEWGFIDSDPVPVPDVEGEDLPKNYRVNVNPASDQKVIPAKRKRTQKQPARDSKFGPSIAPTTNTQRKKLQIQNTQEMDLSHTPNTDTLSLPGCVWDRENWSCAYDTVLTLLIYTLRDSSEVFHQRWHSLSTYTTTFVEFLYQHNVHQLSLLSTLSMNTMRELFRDFLTAYDPRQFIRTGPHMASCSPMLELFTMPSRSTQECLLPFSCRNHNIDFVITLRVPFSIIPTFDTLNLFRNAAPTNRSTVQDWLLYLVNQYNISSSLTSCPLSNDSQCDLHAHSSVLDLLPPFILVELPPEPDHNIFEVNDNLCIATHLPIRYQLCGIVRLGGAHFTCKIFTDQTAYDYDGQLRDGFLVPTNNLPCSSRPYPHLALYRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G353</accession>
    <name>A0A8H5G353_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_005825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G353"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5357361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="213" mass="22720" checksum="3D2CDBB4B54C9ABC" modified="2022-01-19" version="1">MPLAAEKPLPNTVQHVLGRKFASSPDDRSMNGSNFPGLVPLFPAGKEPLPPGVSEDERDAFNQMQKTEKFMTMGSESCAFKTVLAGGGGFAIGAFFSLMSASFAYEDPLIRQQHATLKTTQKAREVFREMGRGMWSSGKGFGKVGALFAGIECIIESYRAKNDIYNSVASGFLAGGILARNSGPKAAFGGGLAFAAFSAAIDSFLRRETPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G864</accession>
    <name>A0A8H5G864_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G864"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="38914" checksum="5C36242C2A47B688" modified="2022-01-19" version="1">MGKKSKNSTPGEDFLALPAHSSTASIVDTHTHLASTFEFYRSKYKAGKYEDVFDFVKGMYRGKRVEAIIDVWCEAPIQRIWKEFADSAVSEEDRKTKWGGLEYWFVMGVHPHNAKDYTDQIEAEILEAMTHPRCVGWGEMGLDYHYDNSPREIQQQVFARQLRHAVRLGKPLTIHTREANDDTERILKEIVPKEHPIHIHCFTDEPEFGQRLLDYFPNLYIGVTGVITFSTNLNTSAIVRNMVPASSSPESIPSKFRILLETDAPYMVPANIYNSIKPINGQVMKGRLPLSHSAMIPWTADFVVDGFKSDSSSGNGNEDENNVPVDVDLVMSVARENAKKVYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB72</accession>
    <name>A0A8H5GB72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB72"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="65"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="43265" checksum="B6AF4611EE5E9193" modified="2022-01-19" version="1">MARAATRSQRTPKASQSQPRPSQSQRRVDSDDEEMEDARSDDAMDVDGQEEGSGDADTKRKASALVRLALFTEHKRAALRREDINKKVMGSNSRSFQRVFEAAQAILRQTFGMELVELQSKAALEKERAGIDEEALEENRKATATKKKATVAGSKTYILRSTLDPLIVEHASQSQLEILDQEHTDRDEEDENETLPQAYGSILSWSTCDQLEPIGILYVILTLILVSGRVISDSELRSHLKRLHLSSDAGVNFDVKSTTPNNTQDLDQFLGILQRQGYIEQHTVGEVKKGKGGGGKRVRSQADNDSGIKYEWRWGVRAYSEVGEKGIAQFAAEFMVTREHEEDEDEDEGQGARNRNRNRRGPNPHEQVEKMLGAIEKAAGSELVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH83</accession>
    <name>A0A8H5GH83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH83"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="62"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5364937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="65854" checksum="99762C58E63B64DD" modified="2022-01-19" version="1">MSFSDLHAARKTNSYVQSSVPQNASNSSARTASDVGEQPEQKPGIEPTKIASFTGLYKPLPSALEIRVSETSGRGIWTKVHIRAGTAILSLKPHVAVLSLQHLNSHCSSCFASATSSVLRRCTKCHVVWYCDGTCQSNDWAMHKQECEALQRWFQAAPSSDVAPPSDAVRCMARILWKRKKKGLEDAWSREIDNMQSHRTSMHPSSFETNTHLAQALVQYMGMSSPADLAQFGLMSAADLVDIISRFTTNSFAITDPSLTPLGASVSPIVALINHSCDPNAVVVFPRASPDPKSQEPVMQVVAMRDIQPGEEILTSYIDTTLPKSSRQKTLQETYYFTCKCNLCSGQLDIDPREAMVCPKNCGGLCPLPVEEHALVQCTKCKAAVQATDTVFDAVRIGCEGLEKASALEFKDPVKAKQLTTNLIPILNRAGLTPSAHPLLGLTRLHQSIMISSFPSPLTQDHLDETIRTATKAITGLSALLREGHPVLAIAYVELGKLSAVDEPSPKHLSEASETGIDEHSQPQSQSLASMSFSSTYPPSGPARLKLAYTTLLKARGMLKIGFGRDSEGGAIGKEVRDMLVSLEKEMSVWKTGVKNALEGLPQKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHD1</accession>
    <name>A0A8H5GHD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHD1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="348" mass="39109" checksum="143CB1CD38A5961C" modified="2022-01-19" version="1">MPIIPVKTRSGLVHFNCTISTPSKTEADAIEPGLPTILFMHGVYLPQLAFHSQFVDPMIRKFNCVVFDFRGHGDTTGADIPEGYGQRDVADDVVRLMDALRLPACHIMALSMGTVPALEIAITHPDRCLSLLLVSPLGIEETPELKTAHEEIHKLWRSGFPEPGVSLEDVLKDAFYGCMQLAFSGKQSDMSDACLAIAFRYAERQWDPAHFHIFRRCTLDLFNNRKTLAVERLRRIRCPLRLFRGNADLAHSPEFTEKVFQNMRDAGCDVKLTSVDNAPHLVSIDNSQITNPVLHSLVMDQVRKPISEPDTVFSPWTPILRDAGWIPEGDEEDEDGFIMHHQGFFGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI44</accession>
    <name>A0A8H5GI44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI44"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034034043" evidence="1">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="23885" checksum="228262CCFDEB452E" modified="2022-01-19" version="1">MRTRSSSPFLSPLLLALLFIFLHPGFYSGVFNHSENDGDVSEAVARRPGSLCPIFAFCDFYKGHNFATRDLSYSLKISPSYNPLSSSCNTASTARIAPPRSFPNGSFVIRVWRIFTASTSRLPSLQRYTREALNGNSEGYYAFPCSQTVNSAMGYGDGGKAWSIDPDDVKAFEIGNTGMCVGGAFFALDLGGGGGGGVPSWIVGDSFLALVLFFGFLCIQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIP4</accession>
    <name>A0A8H5GIP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIP4"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="590" mass="64830" checksum="58D183B72BD7F457" modified="2022-01-19" version="1">MEQLQEEPVLNLSDVMHDETLDDDTDTDRSPRSQDYGTRSPSIFDPEPSILQNQASDENTPTQNRPQSSLPFAVDQFEREIADLLLHQNASAATAALLSAAAQQQQANLSSRTNRDSNTDSSTAGNSITRYPNDLAAVLQAAQSNHQEADSEGTSVNKGPASLTDKILQTTRAAPSFHSLTAGTIVPPPQKRRKIVDTENDRDESYLFPDPEEPGADAEPAHDSPSTRNRPSPISQPLPAEFTDINDILNQLSAQFDTDSGGHNGTSVIHDHPNSPSPRRPSNTSPVLSPSNRKAVQPVASTSANVIEDIGKKGKRGKGNVLHACEHPDCNKTFTRRSDLVRHKRIHTGERPFVCEHAGCGKTFIQRSALHVHSRVHTGEKPHCCEYPGCSKTFGDSSSLARHRRTHTGKRPYKCEEPQCEKTFTRRTTLTQHMRTHDPSWEPDPNVKYSFKAKQRNRKEGDQEDEQVIEDSVRTLSALLQGTTHIAAPLQEESLEVRVASISAEIAAAIAQARQRVYEDDEDHDDDGSGGSSSEEELLARDTIGPNTSGIRGLGDGGRERESGDSDEDDDVPLRLRRSKDAATGQKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIU9</accession>
    <name>A0A8H5GIU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIU9"/>
    <dbReference type="OrthoDB" id="3173976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="35844" checksum="9457927CD7A57F27" modified="2022-01-19" version="1">MSPTPWLHDIAELDPPSPSSSVSSLDEEEVNSRLKPYWHKYTPLLKHRGFRLDTVHDVKEHYRMCNLDFPRNPRRSIDDDALCPDPGLPDNLFRGARIVDGMKVMVKAVSLWSREFDIIRFLSSPTMRAQSMNHCIPVLDLVQVPEDDTAFIVMEEWSSQLIPDSGPCSLKLFLEAIRQCIEHAAFMHAHHIAHLDISLRNLVTDYKGHYAYIDFELSRRFKEPNVQLCGYYRGTEVPPECEERKSNDPYKIDVWALAILILRACKASCPMVYDLLSLNLSRSFSSQDTVFLNWLNWSSQCFTKTQTNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJI3</accession>
    <name>A0A8H5GJI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJI3"/>
    <dbReference type="OrthoDB" id="3247268at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="16539" checksum="002A8695733E3D9D" modified="2022-01-19" version="1">MSSDSLVSSAELAMSKVSLHSNGSQSEDWDRSLTMDESPTDPKTPRNSVAFPADGKDGVEATPSASGGKGKRSLSELMKLHAEKGTDCTFTTEEATRIADVLGRWINASSSPYEDEDDFFAKSSQDDLSLNSSTRPASRDGRPRGQSESVAHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLE6</accession>
    <name>A0A8H5GLE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLE6"/>
    <dbReference type="OrthoDB" id="2685034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="37219" checksum="4C7CA76F5042EF10" modified="2022-01-19" version="1">MQQYSHMNLAERRDSGLDSSGSTPFQSHVPSINHALDETQESFDEGGGQGAKHWSDEEKSKLFKWLMGPGQDDHWNSLRATKNSCLRECASEVFGGKKTYQALKGCYERNFNLFKQIYSFETFHNQNGTLGVNPNLSEADSLREYERRLHTARKAGCDVGNITARTIDNWHRNGWYELFYRRWHGDPATTRPTVNHRGVPTSANGGGEAEEGAELDEALREMNIIPADSNALEPIFESLSYCASLHPDPPSSEYDDDDEEDQFADADGANGFETFTGSEQEELSAVGRAALEHLESIIVYPEGVKRPEGHDDGEDDAEKEKSEEKKDETKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLR3</accession>
    <name>A0A8H5GLR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLR3"/>
    <dbReference type="OrthoDB" id="2348945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="59775" checksum="422C8FE7A481B243" modified="2022-01-19" version="1">MDNPQYYQPLSHALDPSRSTSYTSTARTYGSEHTARPSTSTHRPEHNDPEDSDQDEGIVEEQLARNDTGSDPASPQPKTARQVCVPENHSPQSVLPPTQQEPEKRRPGRPRGSKNRRGRPPSAVPITPTLSKSTYDPPSQLASGSGSNPPLLPEVNAQNQGYYEFQWRVLNLCAEFYGAAEQLLKATSPLVIAQCYQAVPGNKLDPLVMLTEAKTNCDTLLANPSKLITNPPPSMYTTATTAHTPAQPSQPAVTATTSSSSPSSKSPTVISQPQSFVVSMGAPMHYPVYPGAYPATSFYQYPYGQPYYAPAPIASTTTTSTAPQTSTAAIPVASTPTMTTTATSTPAVTATASSGNQGAWSEEEVNRLRKLSADARAAGHTGDAEWTWVVNQWGVGRTRRQILAKAQTLGLKESTSRGVKRRRENDGNDDAPASATSGSNAPTPSLTAATVPVNPHLNTTTPSPGQSQAGNTPVASPSIQNLSRPATTKPPSSVSITPAPISAVNTMPWPMPTVAANTVSPVLGSANTADQRTTSFYRPRPTASDTTHKFVYQNGRTSTDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLW6</accession>
    <name>A0A8H5GLW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLW6"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54112" checksum="F93F1634F7014440" modified="2022-01-19" version="1">MAKLRKEALYTSYSKSLRIVASGTLFLTHTFSLPCHPAPSTVPVVRAHSVSKMRGGSASSLLSLLAQFPHVIDAALIASLGGNDDGQILIQELENEGVSTRLCKVWRGAGVPSAWVLHANDSDTRTVINHNPLPDITHEEFVSLLGPLLVPENYPTIPMQPPTPPVTTGPRSPSLSGSPPTISGTNSPAPFDWIHFEGRSVKTTLSNITGLDGLSRERKWRSRTVFSVDVGRRYRQGIEALIPHVDVLFLNKHYAQATSPQFASSPRAFLLSLMSIAPPHALLVAYWGTEGGAALSIPTKEYFQSSGWVEERTPGIRRRQPLGRQDNLLHPDSVSAIDDTRSVRTGSDFWADGRSRSPSSSTYTAKEDTEDSYSRGGTSSVTNGRFEEGNECDDDNDSQATEVPDEDNIVDEVGAQDAFVAGMIYALSRKIMPGPPYTPSAGGENVGSNGEYDRGRWRQLDECLRFATELSGRKARRPHWNGLAREMARSGWFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMK0</accession>
    <name>A0A8H5GMK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMK0"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034261187" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84759" checksum="F418F14323023651" modified="2022-01-19" version="1">MQLLIPLLFTSMALAVPTRRSCDVSSAVVDVPANSALTPPTHQVSFLALGVGTQNYTCTSAGSYTTAGAVAEVFDVSCLYGTETLSELPSAALQCWEQLPASADASTAIQCLPSAASSILGQHYFVTNPVTGSGISPKWDFTSAAFAGNSDAFVIAARAAGITAPTGSSDVDWLFLTNVKGSLANEIYRTDTRGGQPPASCTPGSAPITVKYTALYLTLGGGISLKMSNLNLAGNLHTLLSGLQVTNDLNAPSQPTSMANYEHELSLLENLPDELLLKILEISWTADFFKFQLALDTEERVKPPQAFSPVFGIRFEDINLRHPAYYLTLVSKRLRNIYLPVLFRKVEFRYAHIMNLFRHVHFNTRSLSLSSSSSPGEHDNSFESFCNFHQSFRLLLLHLLHSESCPQLQFLEYPFADLDLQGRWAEQSQTETERLEVFHAIEHHPSDDLRVFCPCPSSALTALVSRQGRHARSNSELPLQGYPSLNRLLLEIDIGRLVMMNAPAAGTDCDETTPYNFILSLIQRGVQAVKVDFGHRTHATGGLTFGNQSHHHHIPSLSLWLQPTYTGLRELPSLSLKALALGSESGRGGRCQWVDLQNFISRHPLLERVTLYRPWPDAHSDTSTSINRVGVEQMVVVRNRLKDSWDAWKVQEISLTIHHEPNMACVEKRRRLTSHELAEEEMNRFSELGRALPGPGELRRLDIRCRHLGSSNVRYFNNSNLDNDSDLHITFTGECDLFVDERRVLQAIQTIYDSHASKRAQKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMK9</accession>
    <name>A0A8H5GMK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMK9"/>
    <dbReference type="OrthoDB" id="3025610at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="305" mass="33303" checksum="8D4C370906A86750" modified="2022-01-19" version="1">MSAAAQSSPLERVCKISPSKCKICKRALDPNGRSLKNCNDCLDKKKRINDESQKKQREQELQSAVNILVNNAPASSSTKDAPDGKIMKDKHSKKRKAEEPADDREVVQKRAKDFLDAVVPANDAPSATSKPVQPEDSTGDEYQTASHLYRGLKRLKLSSQPPSSNPRVRFHGKHSIVVDPDIDNTKRAALVARDVSKLGRLSFNHRSTISPPILSASFLSLSFRCTCSEQASETSGQGTVKKPTPMNSSAGKDTSKKTKGDLKRKDAEAAGSQTKACKGVIEVTAENDSSNQYMSGQKISIRVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNV6</accession>
    <name>A0A8H5GNV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNV6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="680" mass="75055" checksum="1667D21FB6878406" modified="2022-01-19" version="1">MSHTDLLRRAINDAKSIQELFSKHAPQHPPPPPDVPFAPLHLIVPDTFLAAAHGSQLQERSRSILLQSVEDLKSSCGDIFSRVWNDLWASTSTHPATRSLFPSLINRFRLSVQILFDRELHRLLSTISELRYDDFEEQRQSFNNDYIPFLQRYFEYDSYPTAQDREIMAQKSGMTARQIEVWFQNHRRVAKKTGAKITKREDTSKSSFTFIRQQVPAQQTHEQKMQEIEQQVRIEVAQQELTHKSVGAPRYLRFPGAVDLLNPSRPPCAYPVVFKAPPESHQFQHRDWRPHFPPPPWLRQGVREQPRTEKEVKARQKATHAAYEKMLAQFALLSVRDTTKVDASKPPAATFAIYHVPSPAPHPSFLRSGSATPSRISAASAQASQGRRRKAAPLPKRTPKNPVRRSTPYTGVYATTYSSRNLESQSTSSPSRTPSLEESSPTPSSSHSRTPSLELPSSSPQSRTPSYEFPPTPSALGNLSLELPATSYAVESALSMDFSIAASESFALSLDFPSESFAPSLELPLNLPESTPSPLDSYPPSAFELSPSPSFPSSSLTRQPSASSLISLASSSSSTDSLFPITPDSSTVDLPGYLPPVTIVDPDVQNYLNDLFAPNLQLFPDLSNVASSSFDSSTLGSGLGLGSFDDPFGFDGAKDALNPAMFSSFSDLNSFSVSGTGMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GP96</accession>
    <name>A0A8H5GP96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GP96"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034536201" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="22840" checksum="DB9F69760B998814" modified="2022-01-19" version="1">MVFINAFILASVLASAFAAPVAERQVESRALPSVIATSTAKSYLSELTVATESNSPAYDRDLFKTWDIISGTCDTRETVLKRDGTSVVTDSACKATSGQWTSPYDGATTTDPSTFDIDHVVPLKEAWISGARNWTPAQREAFANDVTRPQLVAVSASSNRSKGDRDPASWVPTSTSFVCTYIKAYIQVKHFYDLSVDTDEKSALASFLASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQC4</accession>
    <name>A0A8H5GQC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQC4"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5369056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="26577" checksum="FC2A324FD9C77863" modified="2022-01-19" version="1">MPRSKKPENGSSDARASSPSGNSSTSPASPSGEDRPTGPLSIIISQEDREAVKVNNANATELKNACDDAVKRYLSRPELFKQIYLHTDVRLGLGWLSVFVAAGTAFYGYKVDFEKSKPVVWAGLILYILLTTIQTLYSYFIEGDVVYVGRRKTFSRRIVTERIALSSHTIPVEGSKPPAYDVTITYVRSTSGGKSLLAKGKTHGVREYNSFFDEEGTMDQERFEKWIGELIEEAMEGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTC3</accession>
    <name>A0A8H5GTC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTC3"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="501" mass="57387" checksum="FF038BA6D19F8403" modified="2022-01-19" version="1">MAPLSLRTYQSSRKRVYLVCANHSNSLTDALLLVNAIPSSQRNMLRLTAKSTQFGKKTFTSWLIESAGTVPIHRRKDFEEPVDNSENMLQLIKALETGDAVCLFPEGMSRYHPTIAPLKTGVARLISDVLSRNSNEPDFEIALLSCSITYMHRQHWRSDVLITFHEPMIFTPKRHPELLKPVDYNAIRAVTDQLYQQISSGTIDSPSWDLVRISKLAARIYAPLGTRMTLGDHVRVVRAFLEALKISDSQHVEPSQFKFDRPRILQLRSELKAYQDELAQQGLKDDRIRKPLPRRVLLYRMMIRASWVAFLLLLSIPGLCLWFPVFATINYIVRNHKRSGPVFDTWDEITQNKLVGGLASGLFVWCSVALLTFPIGMITGLLVPVCMWFSMRWIEDGIAAGRAFVSLYRLLMLGKPKLKALQEQRIRLHGQVMDLALALGLPPDPETYFAEAGGREKGRVRGQWESRARYFSIKRRRKRDWNESLRLYDKVDYPEDDSNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTN4</accession>
    <name>A0A8H5GTN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTN4"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="853" mass="91691" checksum="6F48170D6FF50CAC" modified="2022-01-19" version="1">MTPSLYDFNEAISRIRLHISLQETEESWDTIASSITDLTSLINSTTAHFQHETVVAIREFHRYIINALKSERTRLSGPAVDLVVAAATELNGDFEPLLPLFFPTLLVLCGRTNKVVLNRVKGCIIAIIENTQLVGVLPYFLQHIKEKSPSLRLVVAESTLACVNSSNPSDLEKDARVKDIEALIKATSRDANADVRKTGKKVFEAYQMLLPGKVDSFTAPLSPTIKKYLGVKPKSTVPNQPRPNHLILSKSTSSASNPQQIRKKPSQMLASSTHSMTSTSVPASSSQSSTAAGTSKTTTMPPPANVKKPTRSEQTRSMPPPPRPASRPESRTKTEAELQRSMPAPAQTDSRAPSRSESSRSRSRAEAEPQRPMPVPANSGGRGPIRPEPSGDTYVVRRPQLPSSRSQPAASVVPPMRIRTVSQSAASTSGPIRNFNPVSQSTSSHLTHPKPLVSSGPQRVPIPEPPVTTAPPEKPLLRVHPQPEGAKLPRKPEPPKLSKEAPSLSKKASVKALKVERTQSAQDKASGPSTHPRSQSASSSKAVQPPAVKQVPTKPAATKPAWGGGRPAPAPVPAKKPANTTKPASGKGKVLEEGLKRSGTLSHSARSAPKPGQVALPKKTNAQPSGAPKDAVSKGSSPTPPTEEVAPPQDEQPISDNAEEEKDAVRDKEVTEEKIAEEEVLEEEIAGNDVTEQKETVEEETVEEKGTAEEETTVETSSSSPDPQEATSESTTTSPQVEEDEEPEGDTTVGPNPVIQVIEPAPTTPVKTRVVNGVEPTPISALFADIQRGFMYSPFTPMSPADSYLPQNGRFPKMPLFGEMSPVPEPELDAPDLMLEKLLDAQKVPRHALMDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTT5</accession>
    <name>A0A8H5GTT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3230534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1411" mass="154383" checksum="B509F7178C9C68C1" modified="2022-01-19" version="1">MELAIPRLRVQRDFQSTAYDYSGSIAGPSRFPGNASDAPHDSQDSNTDDNDDDTPKLYASSKLPSTSFSETFEETPAARLKAVLSRISNSSKSKAPESATPSSASTVDLDSEFEIPEIGSSMPSLARESLKDLFSRALREPGGTPQKIAKGRYRRNSIDASEVESSPRVERVQRERSIAKGKRKSYSDDENENSISNYSRISSASTFDSLREKLSSGSQRATKSQPELDHFSIHDGDTSADTIKFPVDFDPSQIPPPAATSTPQHSLRMSFNGQSVSNLMDQDSEMQKAMAGADSFEESPSGITFPASSRHADGKHAADRNSTIRAKPHANFSSPSTSTHNSQPDRHYNEQMPSSASKSEKSALKRSHSDIPSPVLHARERDWNEHLSTSRAKTPDLDHRHSSGKVMSPFGSRDQGSLSRRDSAASLASIESGRSSRASLRSLDSEESFHQKEKERDLERQWNKPRPRTQSRLSTTSLPDPSPRSRTNSAASRPDSRMSVHSRHNSHSSDSSSRANSPHGSLRSSGGEKDLEEEVKAVVDHERERNWNSPHPVWHIHSSVHGHPPSRSSSPLPPSPSPSSPGFSPQPRIRAESLRSLKSPSSPSLHDMQTKSPGGRSLSFTRPTFASESKSSPHHSHSRHPSSSSLRVEELPKRPSSPLPSIKDKLKKAEKSLPFPRSPTSSVSRHDESARTDSKRYSRTLSSPSPSPRSSARKSAEASSNRTSHIPVWTPSKAGRVLFPSPSKASEQEKSYISRDVPSVPSVVLNEPVDESVDGYDKDASTDTDHEDDAVAQEKTPTLRPALLPDSPSLGSSRNHEERLSKLIASPPSPPPSPPSEDVSAPSTPPRRSSFSISKVEFQTPSPPKGGLPDLPGPPSETSEDDTNDHTPLHMNGNLSNMKTPKPPGAWLTPAPKPLLRAQSLPEEDTQTSSGLVTPVSSLSRAHSIPPQTPALPGAWMATPYKKSVRFDSQDTSLETETSAAETTTDSRAEYNPLTPEPESESEVATPIQSNPNGVSPISTPPETDSVQRPISPKPSPRKAKGHIRMVDEFGQERTTEPVVEKVSTPRESPKKDTTTIRIVDAMGRALDDSVVTEERSIEMDNVPLTRAQALERVRKGLSDLAQGFDTQDIRDLQTHDDQMKRLDDVSQNAREKRERLAQGLLAAEAQMKSKLAASRVKRVPIPSTYSLSRMIRSWLFWALVWMFIQVVVIIAMLRRSNAEAQRLYLTRYYDPFYSELYALPDSQSCDFTETLWQLPVPLVQKALARRAFKELAYADFQISDGVAGQAEAKANAVFVDPFQGVDLATVSDDDLEALKTMREAAEDAETELFNPAIDAAEGDEQDALQAGKIQNKVLKLTGLSQVLNIQIAQAKASGDDTSDLEEKLQEEQTKLNTNIATDQKSAGAASKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUB2</accession>
    <name>A0A8H5GUB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUB2"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="132"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5371202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46518" checksum="E0F23DB2006BB265" modified="2022-01-19" version="1">MDSSLYYSDSSAPRTPSPHNIDDRPYIYEHEPSWQKGSLLQELYNEDVYIESQHYPMMRRATFPYVRQDDYAYTQGPYDHQLPVDPIKMEDSYVVPSQQHPYYPPLEYHHLPPPPINSYLGPHPGLPIQHTDDAASKETQYLRRRCFNCHTTEPPSWRRSTLNPGKIVCNKCGLYERTHLRPRPLRFDELRAGNKARKASKAAAAAAGGSTSPPPKSPSVKKEPREGTLARRSSVSSTSSASAGGSDWDDSASIYSNGSAPATSYNSPSLSPSFSLPSDDRQSLSPPLSSAGSSIRLPNAPLSDIASYHGSPAMHANSLPSPGPSPLGLSMSLSPDLAALPPPHSSSFLANPSPRMKSHTISGGSPYENGGFLSPSPCEGLGMRSRGASISGLSLSSSPSELGLSPSGSILEEPVSNWVETSMLKEEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUW4</accession>
    <name>A0A8H5GUW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUW4"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58837" checksum="C88F50717EB4AE7C" modified="2022-01-19" version="1">MNRINTLLRSNYGSYTPDPECISQCLSNTEREIRRNADEIRRLEAQIASIRVEQRGLERRVFRYRSLLAPIRRLPPEVLKLVFESFCNEGATFGEKIWSPPAQLSRVCVGWRDLARRTPTLWSSLRIEQSALETFSVEKIVSLLTMHLELSQKAPLDLFVSIKALEPARLILEMLFSQSTRWRDVNLDLPTSADLEPLRGNIPLIRLLDISGWDIEQQPDDMRAFEIAPSLKALAVSESVENLALPWKQIAYFSIGFGRASQIRNVLSTASEAREVQLIRCIPSGSSDPQNVPVIHSLTSLSIIVDQWDPDFHHWFKWLTLPNLTSLKIAGYESAFPAACTSVFEDNFFPSLLSRSSCTITSLSLINLPLSDSDAITLLIALQSLSSLTIHERDKPQSSASPNTTLTKTFFKSLTIEYNTAFSNRHSPSLQLKRLRSLDLRVHAAFPAKVISDVIVSRWTGNDLEYSAAVSDVDSLTTVKILVLRSKGAMVLDVQELHDSLEAYQRLGLWFCCESKFLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWY1</accession>
    <name>A0A8H5GWY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWY1"/>
    <dbReference type="OrthoDB" id="2929273at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="35385" checksum="C1E726837F0D849A" modified="2022-01-19" version="1">MDLKGSIEMLQNVSKRLQKETSTDTSGYIADLNRVIADLERAKVPSRLPEDLEQRLNRAKIGTETGLFEGFVDGVSGGMLTHYLPVSEGFLVQPQPTYKKLYEDEQALAEEANLSMEVNLGEEDNADEGEERSEKYSDVEDNDREPPEEFLPITSPILPFRSSRTTLNRKDIVSSLPTGSPVKNFDISNLAHVDEANRIVPNEPGGLRRPDFNCVKMLTPRDRLFLLVENKLRLKSQAIRQLEDYMDDYPDCKYGICFVMDHKRLEAGVLWREGNGAIIQRRGGRNAWYSPTSQEFHKIMLEIREYADALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYU0</accession>
    <name>A0A8H5GYU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYU0"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14654">
        <property type="entry name" value="ZIP_Gal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005600">
        <property type="entry name" value="Gal4_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034636996" description="Xylanolytic transcriptional activator regulatory domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="399"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5373786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="937" mass="106290" checksum="D003A7E2C881051B" modified="2022-01-19" version="1">MCLAFPLFWSTLFVTIAGDKVCSNCISARKPCTYLEASKPRGPPKAYVTGLEDRVEQIEALLKQLRPDQDFSDELGPPIIRGSWKDDNDPPPKSSTHSASLPAPLSSTPALLSSHLVMDPSPSQNLHLDIRTRHQSLSLDVSLSDHTSDSESSYSSDPDELFDDYEKGMSRLTLRKASHLRPKGSNDARFHGKSSSMKLIDATRRFKQEHISKSEVTANSESGSQPSPSPRASYPVHARRPEYWRASRWELLWEGLHVDSPELLSSVLEIFPPDDLAEDLIQLYFQHVNAQFPLLHRPTFQRQWREKLHNENIWFACVTACLFAVASRWSDDPRVLPQNTGKDKNGAYDWTLAGWDFFNLALEIHRARRSLFYPATLYEIQTFTLLSMFLRGTDYNTVGWLFTTIGIRKAQDVGAHRKTVYKRKPTVDEELWKRAFWLLVAFDRFSSAAIGRACGIAEEDFDLELPLEIDDEFWETEDPSTAFKQPSGVPCKITGFNLWVKLTQIIAFALRALYPHGSSKVVYGRIPIPGPKETVQQLESALKIWADQVPDYLKWSNQIEDLTFANQSATLYTNYYLTQILIYRQFLPQTSLGVSRMTQPPPIPALVLCSNAAKCCARIIETQLQRKLSNIPNLIHISHISAAVLVLHFWDMKAKEKAHINNPGEDVKPQSIQSIQSVKEDIALFIRALEWAAPRFKNAANILIHLRQSLEDETTAPNAIGLESEDFHEVSQIEPADLSIPLHSWSYNHPILPSISDLPLSSSHRDEVPRAYNLPVQPSSLREYDQRYRPPASHHYQHQSTWPTDRPLHAGDRNKMASSTSQHPVPYISTIRRRTASFTDSPLALRSAHNPDISPVDLPDDPGRLDWENGVRHHVPTSNTRSTPGMGGYSKQQQQSGNWNEYPPRLLDLAYDAPLSQWGYAEHPNRHIYPAGSKLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZD0</accession>
    <name>A0A8H5GZD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZD0"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="41914" checksum="43BEE4D879C022EA" modified="2022-01-19" version="1">MSTVSAAQQEFDFWEFVNAVMYSATIISVRQQASLLWTVSKGDLDADQSCAQCGAPGIQLIPLQHDMEPPMSDWFRSVPYSLEAAAYAARFQLESMASQIRSLKARHQQQRAYIERLKRENAELEQLVAQLSGQHGVYDNQEPSSFINSNGKRPLFDPRQTNTSSPHSVIGVNRLTIPPDQQPPHLSSRTRDGQTYPSSSNRSDDIAPAQQRPRSSKFAQQYAFIPSARPPTHQSSRRPSEQNPQFQERPEPQATNKSLSMMPPPSATRLSGPQSNGKPPLSQPRNMTPLHSSRLDVAASKFYNQNLSVPSTSSGNANHRFSSTNNGKRFVPSAPTHASERLGTGIGRLPIGQNSMPVDSRAAPRSFPGGSGQRVPFVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H163</accession>
    <name>A0A8H5H163_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_000121</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H163"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5374762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12902" checksum="D1C16EA9A4FD04F4" modified="2022-01-19" version="1">MSQYVHVPKSELDEAQLRQLEEHEISQGPLSVLQQAVRNHTQVLISLRNDKKLLARVKAFDRHSNMVLENVKEMWTEIPKGKNKKPVNKDRFISKMFLRGDSVILILRNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H177</accession>
    <name>A0A8H5H177_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H177"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="159" mass="17250" checksum="8EAABBF58E4FA162" modified="2022-01-19" version="1">MQAALRRTCFLSSRTLPRATSTSRVLSRPVLSRSIVTKKYTEEHEWVSFDDSTGIGTVSITEHAQAALGDVVFVELPAVGIKVTQGDQMGAVESVKAASDIYAPVSGTIEAVNETLSSEPGLLNKSPEDKGWLCKIKLSNPSEMDKLLSDSEYKVKCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H219</accession>
    <name>A0A8H5H219_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">D9758_000122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H219"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="359"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5375224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="624" mass="69729" checksum="30F686E28A9F1975" modified="2022-01-19" version="1">MGRLRQKGKAGAAKAYITRSQATKKLQCSLADFRRLCILKGIFPREPNNKKKANKGSSAPTSFYYAKDIAYLAHEPVLKKLREHKAFAKKLSRALGRGEWSSAKSLEENKPVYKLDHVIKERYPTFIDALRDIDDALCMIFLFASLPSNPRLPPSLIENCSRLAAEWQLYIMHSRSLRKAFLSIKGVYYQAEVMDQTITWLVPYQFTQNIPSDVDVRVMLTFLELYQTLLGFVFFKLYTDAGLVYPPPLDLKKDEGAAGVGAFTLQDASSSTAAAPTKSKKVVEVEGRQISGKDVYQTIKSLASTTPDANGAPDDTTMDSEPTSREAEEEFILQPSKSDPQPAAPLTTLKSLETLPQTVNTSLFAPYTFFLSRETSRPMFEFLVRSFGGRIGWSATSGKGSPFDESDESITHVIIDRPIVESSNETLEERERRSRRKCVQPQWVVDCINAGKILLEDHYAQGKTLPPHLSPFGEYEGAYDPTALALGEKDDMSVDGDSASEDEDEDAVMDEPESAEAAVLKVVAAAATDSDADLRAAELAAEAAGVDPALFEKEVKKSRKKVKSDTNEDAEKDMNKMMMSNKQKKLYEKMKYSQNKRNQERANLEAKREQIQKQARKKTKIARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H222</accession>
    <name>A0A8H5H222_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H222"/>
    <dbReference type="OrthoDB" id="3270770at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19407" checksum="DBFC75637F75C194" modified="2022-01-19" version="1">MSTSQTQLESSDEAFRKAAAELEAAMDQYQTVKREGGSDIKKHEENVARLMRAVGDTAADPVAQKYYYRKAEDFASGDDGETLTDLDMEEGRAGASANEARAARRRRRMKLGIWKDMCKGLAIVVFTPLIAAGILVYGVGHWKCFDLGYMERILKKMEGACATDGEREAEGEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLF2</accession>
    <name>A0A8H5LLF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLF2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="11028" checksum="9FB6E693F1584D80" modified="2022-01-19" version="1">MARFSSNPIVVTPFCYVHLPHTLFIYSSRDRRVLDASLQDVSMRIHLNYFHPEEGCRWVRRRASKAGSSGGVRRTVIVFKADKSTLVKAWLGFACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ74</accession>
    <name>A0A8H5LQ74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_003222</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ74"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="381"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5365572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="63320" checksum="83284700EA5DED7D" modified="2022-01-19" version="1">MCGIFAVHGVENPASYRARAIACSKKLRHRGPDWSGCYVGKEAILVHERLAIVGVDTGAQPLISEDGKLVLAVNGEIYNHLALRASLGSDVKFKTHSDCEPILALYKKYDKDLCNMLDGMFSFVLLDESVSPTRIIAARDPIGITTLYQGWSSKKPGAVYFASELKAIIDECDKIISFPPGHVYDSRDNSTTRHFQPSWWDGDLDGPNATTPTQSADLELIRTTLEDAVKKRLMSEVPYGVLLSGGLDSSLIASIAARETEKVARAQLELRQKKLQESISGPPTPTPGLINEESTLVAWPQLHSFSIGLENSPDLLAARKAAHFLGTVHHESTFTVQEGLDAIPEVIYHLETFDVTTVRASTPMYLLSRKIKAMGVKMVLSGEGSDEILGGYLYFHAAPDPKSTMAWGLEARVPFLDKAFLEVAMNVKPEEKMFNKGKLQEVDKDGCPKMEKYILRKAFDCAPDGKHYLPRSILWRQKEQFSDGVGYSWIDGMKDHAASTVSDDAFAKRAERWPDNTPDTKEAYYIREIFDGLFPSEAAAGTAIRWIPRGDWGCASDPSGRSVSIHNAAYQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQA9</accession>
    <name>A0A8H5LQA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQA9"/>
    <dbReference type="OrthoDB" id="3366674at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="334" mass="36065" checksum="DEAB1B1278982717" modified="2022-01-19" version="1">MNEPKGSKNKPKADNPTVPKTPKPPKKASNTTYSTSTTAETPKLTPKLTPKPPSRPRAKYSPDNDKKLMAMFLEQKIEGNATDNGGWKGKALTAAEKALEGSELESGGAPKTATGIQEHWDYLKGEYKVFVMLLEKSGWGWDDENQCVIASDEQWEGLIATDPHLALYRGKTFPIYKEMKELLEGALALGDQTFQPGNTSDSSDLDNSLSEEEETIVGSDPKMGSKCKSSAVGGKPAKRPRRDRGGKLSTASSIVGLTHAIDNVAVAMASSESDADKEAKKKAGQLVQGMDGLSKTEIAKLLLLISKDVSFTELLLDIDDQETLVEVVRLQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRI2</accession>
    <name>A0A8H5LRI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRI2"/>
    <dbReference type="OrthoDB" id="2941894at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25641" checksum="135FA3B46FD4A899" modified="2022-01-19" version="1">MPSSEVDPSDVTGSSPTPVIPPSTSSSTPLSFSSNLLSHIMSTPSADTTRPSVAIISLSTGLFNHDKLSKDQNNFSSWKQQFIHTLRMNQGANGYLNGDIAPPDRSSEPRAYSNWKANNGSILGFMGLVIDEAEQEVIEDATTAKEAWKLLVQRHAQEGPVKQVQLIQEALGTRYSSLEKYTTTSSKLTTLNKHIFGMGTLNKELFLCITMINAMSNVPELRATHENVTQSLALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT10</accession>
    <name>A0A8H5LT10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT10"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="5">
        <location>
            <begin position="432"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="821" mass="89144" checksum="391D31281ACBCA01" modified="2022-01-19" version="1">MGKSQKKKAMRRHNPVRVPDSHLPRGLSSASSTSSKSEAILPIIQKMESADATERKWACAAVSNLIQNDPSTRRLLQGKNIVGALITRLTDSEEEVMVEAMGALRNLCIDGGYDICAEMYNKNILTPLKTFVPKISEVLSQYLENPKTAPENAQKLMYEFADNVITTLWCLSETSNKALNAINNINLIPFLMSFLAAREKLPLAPVVAAAQCLYVLTDDNDPAIRSVRTDAGYISCLVSMTRLNENAPNVNGKAKDPNDYRVITLQVLVSGILRNISPLPPPTPASFIDIDKEIVLPLLQPIISSINLSEVASNVQQFVDAQASEPQIEKLSLKHTPKTDHKSQYELELEQLEGRLRTVQLALEILTGACATLPDPSPASAEDETDEAVDGMEDDENEVFDDMDVEMSTDKDPDSAQRTSLLPPFVPALLALTHPNALSFPPLAAPSSHPPTTSALSAIHIGAMECLNNIFLSLATSPNPAISADKEAGSKIWNELWVALGAVGTEGGLGQEKRKQIWEVAVGVLWGVGTVWKGSVTASENQIKVLMQFCDTSTDEKLRVQCIGALECLAQYQDSIEDNLLIAKYLISLLPTAATPSPVGTEPMIQAASALIDIYSDESMPYDINFRREGFLQVLASSVEGVRKAVKGIDRHKEGGRDLRRRGDEGARKALTLPAAALLRSGPTKRHQVMAPSIVHTEDANPVLPVFSQAVISRGYVYVSGNIGCDKNFKLVEGGIKAETRTALENIAVVLKAAGSGLEHIVKANIYLTDMARDFAPMNEVYAEFFEKGKMPARTCVGVAKLPFTAVFEMECMAEIPGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT33</accession>
    <name>A0A8H5LT33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDP-fucose protein O-fucosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT33"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5368391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="48699" checksum="AAE1B6956A7CB4E0" modified="2022-01-19" version="1">MDWQLPIQPAVDLPPLDADESDGGVVGGPTKEDLVVEMDPLNPLAVLNGPPREHFRDNLKEGVQYITSWPDAGWTNDVMTYANLVYLGLITDRVPIIPMFYPSHIGYDVPPIPFRDVFDIDRMRKLIGKPILEWQDLKDPKSEALENLGCWNVWESTLKPPPDVSYTKTPNWVKMFPEWPHDRHSSFWTLARFAFPEDRAQNLGTPLPSPKTQVSLPPDEQLLCYDYLYYVCAQQPFEFEKSYSPAWRFVAKYMYWAPSLQAIADEYIRRTIGVNDNKPIPPYIAIHVRRADFANACTTDFKVPVEDCFAKISTYGRRVDEVKAEILEKKGVHIDHVIMTSDERDEGWWKEVEEQGWSKVDHSMTKERYGDWHPVLIDAVIQSGALGFVGTARSTMSVLAIRRVEDWNGGVARMTQWGTVNADDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTC0</accession>
    <name>A0A8H5LTC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_002304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTC0"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000097">
        <property type="entry name" value="Meiotic recombinase Dmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="106"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5368646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="352" mass="38322" checksum="0AD2ED42244EB403" modified="2022-01-19" version="1">MPPRRAPSQASAPASRPASPAAEEDETPWFDSVDELQQHGINVQDILKLKSAAINTVSGVNMTTRRQMLKIKGMSEAKVEKIKEAAHKILGSSFSTGIEVQDKRKRVLVISTGSKTVDAILGGGLMSQSISEVYGEFRTGKTQLAHTMSVVAQLPPDLGGASGKVAYIDTEGTFRPDRIRAIAERFGVDGNMALENILYARAFNSEHQMELINECSLRFAEDKDFRLLIVDSIMALFRVDFSGRGELGERQQKLAQMLSKLTKLSEEYNADCRAPDEPSTIPLAADPGATMTFVAGGALKPIGGHILSHASATRMFLRKGRAEERVAKLVDSPDRPESEASYKLDEGGWSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTL0</accession>
    <name>A0A8H5LTL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTL0"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="535" mass="58802" checksum="90B7D4C7BFA8B768" modified="2022-01-19" version="1">MASEPLEAEFAHPPVLTREQEDEFRQLAQEGPLSSAATISTESSPTLADLKQAYNEKGYKVVEFEKGKGEDPREWNILKKWYVTLTTAFLCMAAALGSSIVTGDMAGPVTELHTTQEIVNLSVTCFVIGFGIGPLFFAPLSEVSGRRLPYCISSFFFFIFTLPSALAKNSATLVVGRQLAGLAASAPICNVGGSVADIFTVEERGLAMATFSFAIFMGPVLGPLIGGWIGQEVGWRWIYWVLFIFTGLCFALTLFMPETLATALLSKKAKKLRESTGDQSYRSLEELGRPPFSETMKIALSRPLVMLFTEPIMAFMTLYLSFIYSILYLLFFAFPLAFQEIRGFSIGMTGVTFISVLLGISLAMLLMPLQERIYARATLNGTYPEARLYPMMLGAIVLPSALMLFAFTGAYSWVHWIGPCVAGFLFGFALIIIYISGNSYIVDSYSDYAASAIAAKTLVRSLVGAMVPLYINQMFHHMGFQYAGLLLALVGVVIAPIPFVFFRWGENIRARSKRASKDVKKSGINGDRTEKAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTQ2</accession>
    <name>A0A8H5LTQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTQ2"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="28769" checksum="38467B8CD241CBF8" modified="2022-01-19" version="1">MLWADPEASFSHITFDISVHSPTRRAFRDLATDITNGAVLHDVLMDFDWFSHTEFDTVRFNARDAPIDIKVTGKCTTNAEIDVDFVVLYETIQLETSNAPLNATIWAIDDSGNGGNTILLTNSDGPIDALIAMSSNSTEAIFRASVHTTNGDLNVQSGMTGRHLLLLEGSTSNAPGFLALPEQYEGTFDISSELGTTSLVFDPDKRDSHGRQRAVDMKVDETEHKAGKIYWGEEPPNMNQGSIKMSTTQEDVTITSFREFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU34</accession>
    <name>A0A8H5LU34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU34"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="528" mass="56411" checksum="A91DCAB22BCD0393" modified="2022-01-19" version="1">MIRVQALSWLCSSPRLVIGHFRLSVVLLLKREAWRGLSNTNFMRFLAGSLLSCALVSAVTAVQLDLIGRRVGYSSLYRRDDAGQFGNGSHALSNNADILYFTNITVGGRQFTVVIDTGSSDLWVSGDVPGALNLTNPAIVTLPFAKGQVNGFINTVEVQYDGFTIQDQAFINAFDVEDIGLQIDGIIGLGPSANSNLKRKVGGDPRADPPLDRIFQENPNTPNFMTLLLSRNTTLEGTSVHTWPAQLAIGAVAPGLESIQGMPKLPALVDQFGIQHWQTLLDENGIAVNGQRISTKTSIQNPTAGTPNQIHVALDSGFSIAQVPKYVADAMYSDVPGAKFIQDGATELGQAFAGIVNFWCLPCEAEVNVSFFFGGNEYPVSPLDLNVPVGKDPNGQEVCIAYYQQISDSLLQNQADFGAFDMILGPAFLRNVYTLINFGNFVGGSTSNVAPPFIQLLSIADKNQMHQDFVSARLNGGQNGGQSPTDNASPADPGSGSSSHDDNGSPSHLPGILGLSLGLSVLVYMLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ33</accession>
    <name>A0A8H5LZ33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase</fullName>
            <ecNumber evidence="5">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ33"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="461" mass="48507" checksum="167EA11B7B4CDC1C" modified="2022-01-19" version="1">MQHLIKAFASRTAFQRPFAMSTTSTDVIVVGAGIAGLIAAYNLTRAGKSVHVIEARNRIGGRAWSDDSLGFPVELGCMAIHGYVEGNPVRQYSSALGLNTKLLPNARGTLLTADGPLDKAVAGRLSSNLSAAMARLSSIASDSDALPKETSVADVLLAPSSPLYEGLLEEDRAMATSLARSLEIGWGISLEATSAYYAGWASGIAFAGSDGVVVGGYGKFAEALKTAAEQTGKGTFTLSAPVEKISQRDDGVHVLSQNGSTYHAQTALSTIPLGALKTLPGDFFEPSLPTRRQKAISRTSVGALEKLCLSYDSLWWDPDAGPFNLLTENAVILAIPLSTDPATLHVLLPHSALNLSGEDVHAMLAKAIAPGQTVPKPKKIFGSNWKTDPLAYGATSSPTMVGQDRTPLDFAEAARPVWNGLLGFAGEATEMNHRGSVPGAILSGQREAERILNLLNRRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B1B9</accession>
    <name>A0A8H5B1B9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000498">
        <property type="protein sequence ID" value="KAF5314811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B1B9"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="134"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5314811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="413" mass="46320" checksum="54B41E34AD849E32" modified="2022-01-19" version="1">MGTSEDGNDPQQGNNTIGHHIGNQSRNNSASQRQIQENSNTGEQTTVVPQSMFPNASNFTMTGVTISNVGRDFIQTTNNNFGVPANEKAEILKELKEKLNPIAKPARKTDICLEGTRVKILNDLCNWVIDPNTTIAWIYGIAGTGKSAIAVSLARKIRKIDTKKEVKLALTFHCVKGQETSDVCNLVPTLSYYLAQVFPEYGKGLLESLNRDPSLDGISLPLSEQLEWFLDPSLFGKLINKSSEKVVIIIIDGLDEWGSDSHRSELLRHFKALFQFAWLKIVVTSRPNPEIREELMGELAIRKINLTDYIDTADDLKRLIMSKLPFITNEKVNNMLAKANGLFIWVTTALTFIRKGVDKDGRLEIILDLQTSTKDELQPYEPLYLLYKTVLTESFSQPDNLKYLKAVVGQFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BJJ2</accession>
    <name>A0A8H5BJJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018412</name>
        <name evidence="1" type="ORF">D9758_018883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000409">
        <property type="protein sequence ID" value="KAF5320388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000390">
        <property type="protein sequence ID" value="KAF5323663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BJJ2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5320388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="8040" checksum="6E459683418441F6" modified="2022-01-19" version="1">MAHFVVFGSLDWVAPDFLKSIDIPLPAIPPLPPIPPPLLLDPEPKFLHPGLYSMVIEPSESDGNGFEVAQPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRN8</accession>
    <name>A0A8H5BRN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000378">
        <property type="protein sequence ID" value="KAF5327981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRN8"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5327981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="660" mass="73441" checksum="9AE4E4B3885044A9" modified="2022-01-19" version="1">MRPITSTQKDNILSLLQTSASSREISAKTGVSKSKIASLAKEMYPDKENHQAGRPRKLSTTDERAAIQQINTGKAENATEVARNINPLLDQPMFQRRLLTVLRSEQLRRHKELIERLGTDGMSSDEEVQISPYQRVYHVCYPCWRAPVLAAFMHTIDRMALLYRFDSRNFHGSPPHERIRPQDLGDPDIYVDGKFVPQLPRNAYNQNWLRTQPQRLLQQYVRPTEEQYEFVHDPQTWNHLTSSTLHSKLTLRDAVVSSVAFSTGGDLVAAGTKSGELRIFALGTKYPPASYQLASSITALIWGKDASSEMLFVGEINGHIHRASKHFMQQHHDFQLTTFRDMKGPITALAVSNYACLLFAGDGGRVVAYALDTRVRRGPATTLPPPSEKEDSEPVISGMKVKEGPEEVVIVVGYLEHGISAYYAHRDNTVNVANLRLYWTLGPRRGHFLASWDVYQRQQYWVVAAHNLCDGIELYATNPVSKPDIAQYGQLVSATGLQHKNGVLPVGFLADGQWLVYGSARGNTFIIDHNTGRKVEILNDHNDPDCSVFSLATWADDDKGVERIAAGTRDGRDGSITVYEYNETIAPETPRGIPLSTSPNRDTKSPTLEEGGAPGPPSSAPKSRLQNESWKSCFINVLGLVVALTALALGYYGSRTDVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BT03</accession>
    <name>A0A8H5BT03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000375">
        <property type="protein sequence ID" value="KAF5328013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BT03"/>
    <dbReference type="OrthoDB" id="10587308at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5328013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="29616" checksum="C58C4129C7DDC8B1" modified="2022-01-19" version="1">MAADWSTCGGLYCVGSMAADWSTCGGLYCVASMAADWSTCGGLYCVASMAADWSTCGGLYCVASMAADWSTCGGLYCVASMAADWSTCGGLYCVASMVADWSTCGGLYCVACMAADWSTCGGLYCVASMAADWSTCGGLYCVASMAADWSTCGGLYCVASMVADWSTCGGLYCVACMAADWSTCGGLYCVASMAADWSTCGGLYCVGSMAADWSTCGGLYCVGSMAADWSTCGGLYCVASMAADWSTCGGLYCVASMAADWSTCGGLYCVGSMAADWSTCGGLYCVECMAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BWT8</accession>
    <name>A0A8H5BWT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000343">
        <property type="protein sequence ID" value="KAF5329827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BWT8"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5329827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="35017" checksum="5E451EBC19ECE112" modified="2022-01-19" version="1">MWRAKWSNSDVDIMIDELKNQKAQGNQSQSGWKPDTWTTVSKCIIAEGSQEGAEKNPKKCSDKYGTLKAQYKTVHYIRTKASGFGWDEQKQMVVATDEWWDRHLEKFPDDSKWRTTPFPWYDDMFILVDGKIATGDNVFRAGTASQPSSQPSSTGSQVVLPLEPSQSQEELIDWPSTPPASAPPPSSNSNLTVLASVSTAVPISTPARKRLRADSDPFTPPKSQKRGKGDQLGDIASGLHSIGRGLAANEPTPKRRRKAIALLEEDADFSPDSKRKVLRVFRREVDIADTFLSISDKETRTGYLLDELVDIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0J6</accession>
    <name>A0A8H5C0J6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000298">
        <property type="protein sequence ID" value="KAF5332945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="667"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="700"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="736"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="799"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="865"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="898"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5332945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1459" mass="159583" checksum="DC741A96250BC906" modified="2022-01-19" version="1">MKRSIGDVAEQNKRKRLVLTDVDGGAVARAAENDMYLDGQIPQGSSIAAGRDVHMNNVQGDQSQTINNDYHQTVNSNNNIQIGGSNTFVVQNAVTMDKIKDWLKAPDSSTNYNAAYETMTKGTGEWLLKDSRLIQWKENGGLLWLQGKAGSGKTFLLTNVITSLKKEGHTVFDVYFDTLDQTKVKATYKGLLSSIMLSTGIKFNETMLQNLYQQYDSGTRQMHTDAMKATLLQLLEQHSSAIYIVMDALDECQAQDQHLVSRFILDLLEIDSKIHIFASCRHAASAIGVSSATYAISLDEQVVMSDIQRHIEQVFQKRPLSVNVHKEVTEALVDGAHGQIRWVDCQIQQLQELATRKAILDALKNLPEDLEETYVKALLRTKKGHQKDVQAILRWLLFGYTLLTLELLPEILRIDFEGRKLEAAERIEVNGVSKIIDSTLVVVQEINWHHNTEHRLQLAHPSVKEYILSDQIKSSSAALFHVNDQLAHNFIAQSCMIYLVVYGEDESIDKRNLHLLYYAARSWPNHVKNLQQLEDPIKSLSLHLLTDTNRSCSQWFRATWRHTNVIEGSASPLYYASSIGLSNIMLLLIEDGANINAQGGKYGTPLQAALHMGYKDIAKLLLEKGADVNAQGSEYGTALQAALHKGYKDIAKLLLEKGADVNVQGGKYGTALQAALHMGYKDIAKLLLEKGADVNTQGGKYGTPLQTAFALHWEDFVKLLLEKGADVNAQGGPYGTPLMAACIKGYEEIVKLLVDKGADVNVQGGKYGTALQAALHKGYKDIAKLLLEKGADVNTQGGKYGTPLQTAFALHWEDFVKLLLEKGADVNAQGGPYGTPLMAACIKGYEEIVKLLVDKGADVNVQGGQYGTPLQAAIIKGYKNIVKFLLEKRADVNAQCGTYGTPLLDALYMGYKDIVRLLLEKGADVNAQDGRHGTPLQGALYKGYEDIVMLLLEKGADVNAPGRKYGNALHDTVYYGHKDIARLLLGKEEDGNARGGENGNALQVVSYRRKDIVRPLLLKREDVNAQGGKHGNVLQAAFYYGHKDIARILLEKGADVNAQGVIYGTPLLDALYMGYKDIVRLLLEKGADVNAQDGRHGTPLQGALYKGYEDIVMLLLEKGADVNAQGGKYGNALQTALHYGYQDIVLLLLENGADVNVHVAKYGTALHAASYMCYEDIVKLLLQKGAEVNAQGSEYGTPLQAALFKGSEAIVRLLVEKGADVNAQGGEYGTPLQAACYKGYKDIVRLFIEKGADVNAQGGEYGNALQAASFQGNENLARLLLERGADVNAQCGKYDTPLQAASLKGNKNLVRLLLEKGADVNAQGGKYHTPLQTAFRYDHEDIVKLLLEKGADVHVHVQCGTYGSPGTLLQAAINKGYENIVEILLERGADVNAQGGKYGNALQAACYYGLPHTVRLLIEKGADVNALGGEYGSALQAALHKGQEQIIKLLLKKGVDVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0Q1</accession>
    <name>A0A8H5C0Q1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000293">
        <property type="protein sequence ID" value="KAF5333020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0Q1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="22051" checksum="A1469A5029FFCE29" modified="2022-01-19" version="1">MPPRESLQLQLDDVVDAQGRATIPEINVATDYRDKDRNVTPWESSSTTPPSPPPKGPRTFAQKLSLSSLRQGSQASLTYLRQGSQTTLVNYSSRSSESHSIYSDETHFNMVPHPVPDDPLLSPDTSPKREIRKAKSSLNLIPKSSMFSISKKRSKSHLRPDSDDAEHPSLLPIPPPLPDYKSFLPLKPASPLILLCSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2K0</accession>
    <name>A0A8H5C2K0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2K0"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="99" mass="10865" checksum="9CE3586C921ABD9D" modified="2022-01-19" version="1">MSPLALVPLDDKQEQEHVRDSGAGLMSPLELPPSSAYDGKAKRVVDLTVRVEKIGRFPEAHSGFVDVWKGVWKDVHGHESTVAVKVLRSRIGDPNPQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2W3</accession>
    <name>A0A8H5C2W3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_014820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000266">
        <property type="protein sequence ID" value="KAF5334175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2W3"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="250"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="703"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="805"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="805"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="948"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5334175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="107140" checksum="47C290E0607C7E1A" modified="2022-01-19" version="1">MDALKSLMQPLVAGAGGSSVIDGMKLVVIGGTVETARRMSSTAWSHFVNSFFLTAHFSEEDYPYDWLMLWLSRRPEWQRSREFETTTRSTTPGFSRIADNSFGDEDDEDFSGAIFDEGDAPGRAKTRVVFQPTFDTTHTIYYRGHWLRVRRSRKTDGSGCEVLTISVVARNNSILKQLVLQAKREYEAEAIHRIQIYFADQYGSWRWTDSRHKRPMNSIVLNPGVKEMLLNDTKDFLGSEKWYADRGIPFRRGYLLHGVPGSGKSSLIHAIAGELMLDIYVVSLSSSWISDATLNTLMGRVPKRCIVLLEDLDAAFTRSVGARGEDEKNSKEKDSKESNNNNNGTGSGSGSGSGGSGSGRHRRRGLHGNSGNGDQMGDCNTLSLSGLLNALDGVAAAEGRILFATTNHLDHLDPALSRPGRMDVWIDFKNASKWQAEALFRNFFPCEEDELKEKAKRHRDDDEDLESESDDDVPRTRYSSTGSTAVERASHSRTPSSSVSITPSMSRSTKGGSTTSDEDQEDADPMSLKGSPHPMPMNMGMSVGMDGIPMAIPPPPPEIELSEQELAEFESLGLNLGSPIPISSLSSVPSSVSSQSPAPSRSSASPIPETFHGPPKSSTSLIAMAKKEHKSLDAATVKNEPKGSWRNSTSFGALSSFSSSLPTLSSVSTTVSSLAASSGVSSVSSTLWNGTSTLISSTTSLVTGVPAATEEEASATRGRSGSRTRTGKPKRKEFGSTNQAYLPPSSNDANSSSSKDSAKQPGHSAKPLSAQTLSMLAKKFADGIPEEEFSVAALQGYLLRNKTRPWEAAEGVKEWVEKEREEKKKREGKAKEKEKKEKEKKQKEKARKEKEEKEKERERERCQQVSPLPVVQDGTSLNPSTTVPEEQKTPDPSITEVVIMTTTTVEADLPLSTEPVPVVPPPLDSQDDSESDSESSSDSDSDSEAENIPPPTGRGLPLPPSPPSPPLTIWQAPPGWGTPSDLGGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3P1</accession>
    <name>A0A8H5C3P1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_018733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000267">
        <property type="protein sequence ID" value="KAF5334134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3P1"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5334134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="450" mass="51238" checksum="A80C99FF66DD1E05" modified="2022-01-19" version="1">MFLFSMAVPRQPKLEMSFTAKWTDTEGLNTLKQIISRRVPQWPNGLRDFQLENIPRVLDGENLLVFTATGDGKSSFYDVPVLVHMELAANPQLYAPFPIRETPVAIVVTPTKGLANSIILEARGFGLSGLSYCHETLVKYSAQDLPGLICKCTEWQIICVDPEHLATKEWARILQNETFLKNLVLFCVEEAHLIRSWSPNFRPQFEFIGATARGFIPEHVSIVALTATCAPGPHTLAISQSLGMFGSSYHLIHHSNERINMQLIVDPLKCEKAVPKFAKILDYLRDGCKTVIHVKTIPDAYDIYEFLWRHIPPGINRLRRMQMYHSLCTDDYNRNTFERIDNDPLLQVVIVTVAFMVGINCKRLLDSISYNFPLTIDDFVQMMGRAGRAEDVTCRGIAIVPEKLVQQAKDFMHIKDDIPSISISRNSTKRLKDSYQEQITKEERRQRGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5F3</accession>
    <name>A0A8H5C5F3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000259">
        <property type="protein sequence ID" value="KAF5334478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5F3"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="34160" checksum="218FB5C5018555D7" modified="2022-01-19" version="1">MPLPTSSTPCLQRNAWIPIDVQGGQLRIHYLDQHPTPHTQSRGTILLIHGFPQTSYQFRHVLTPLANAGYRVIAPDYRGAGDSSHPASGYEKQTMAADLHTLLQHLQVDFPVHIVGQDIGAMIAHAFATSFPNDVISITWGECPLPGSSFYEASKTSIEKFHFIFHCVPDGLPEALVSGREAIYLKQFFDRLIIRTEGISSGDFNHYVEKYAQPDGMRGAFEVYRAFEMDKRRNLEWRETNGRCKVPSLLLSGQLGSHASEARRMGEEFYEDVKTAEVEGSGHYITEENPEDSVAKILCFYDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6I3</accession>
    <name>A0A8H5C6I3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000247">
        <property type="protein sequence ID" value="KAF5335048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6I3"/>
    <dbReference type="OrthoDB" id="3053610at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="236" mass="26461" checksum="0FB2654831F7E483" modified="2022-01-19" version="1">MASFLLRFHGCLLIGAMAAFLLYGMVLILAAQYFRDYPSDHVALKMTIALFLIAATIQIVAGFGCVYQVLIDEFGKLVDHIYTYVQLYSSSANSKLTIFDGFGKQVWVDPNRGDILYRFSIPMFLWNEDMDIIQEELFVNSTDSLALWALARVTINDRLSLLYEAKPIFVAQECVHVINDLFITSSLCYLLYRNRYRSGPIPGNSTSASTADNDINSLITTLLISALNRGVIILAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7U2</accession>
    <name>A0A8H5C7U2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000223">
        <property type="protein sequence ID" value="KAF5336739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7U2"/>
    <dbReference type="OrthoDB" id="2526537at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67788" checksum="0F9BC7372B72DDF7" modified="2022-01-19" version="1">MSAAQSYTPHTHMLATCADYNDVYRRPIAFAPVSSRPQLHLPKRLMQDLFNDFTHTPYRFHPIMPYDRVRAHLAGCDWQPSSLSPQECVLVHCIFAIASTVSTDPLIIGVEPFPEECINILTTIHPVKKIKRDLREIGRMRDSVGLCHQLRAEAVRQARNEGIAVWVSPENAASCFLLDVLVSQYDGPHSYGAAFTWQARRLAESWYQHPQLYNGIFGTRDHSVKWASYFVVEVLEALHSDRSVDFSALDEQLICGHDQLSLEELASLLSQGCNTWQFYGYYISILFQITRRAREVNERIKGPCARRRPYDLQLIKRFAASLHLLHDVCNAFSKHGVRLACQNQSQSYTILAVVRMVSIGWTNLTLCFHKTMKEMLEENSVTDLYTATSGPHGTYNYSSLAEVELAPVFLAVRTLTCKAAIEFSEMIEDIYPISRLAQQKIVGGDLKRWVDFVIDVTDTGVMSASVGTQTLVRLRDGLKIAGFMWTNYTDLVEVIDSQVSVLMESSASAQAPAHIFTLDHNPDYHHMNPHPHSSSHHFPQSSSVIASNLDLDYNPDIYYHNLDFNPDHVPSASVPPGAGISPYDPLLSGYTYASRSLDSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA54</accession>
    <name>A0A8H5CA54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000216">
        <property type="protein sequence ID" value="KAF5337524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA54"/>
    <dbReference type="OrthoDB" id="5106486at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24410" checksum="68033D1C4EC67D46" modified="2022-01-19" version="1">MGTSEDGNDPQQGNNTIGHQIRNQSRNNSASQRQIQENSNTREQTIVSQSMFTNASNFTIPGVAIGNVGRDFIHTTNNNFGVPANQKEEILKQLKEKLNPIITPARKTDTCLPGTRVEVLQDLCNWIIEDTTSIAWIYGIAGTGKSAIAVSLASKIRDMEEEITLTLTFHCVKGQETSDVSNLVPTICYHLALVVTEYGQKISHIFKQEFHFLSKWRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFR3</accession>
    <name>A0A8H5CFR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFR3"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5339712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="235" mass="27319" checksum="42B1CA87C26B74C0" modified="2022-01-19" version="1">MPDPKGLVFTLVESGPNISEEEYHDWYDNEHAPARLTIPSFYNATRFKACDGVKPTSLTLYDISEPRVANGPEYQAVFANGSDRDKRMVSTLQYLTRRSYSVIYSLSHPEASAFLPPKFVFYVAMEVKPEGEAYFNKWFKEEYIPMVMKIPGWLRSRKFTLEEHILFRGCVKPEVPVYKHLAIHDFSSDGYRETAEIKAATSTPWQNEVMKNVVGREMRHFEFLKVYKCPEMTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGP0</accession>
    <name>A0A8H5CGP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGP0"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="82059" checksum="37E47FCDEC678D2A" modified="2022-01-19" version="1">MLATGSTLQFFPPPGPEWSELPPEDPGSVHEELEEVEFSPTLICPECLYTFPCIQRTHSPSTLSQIRAKYVPTPTESAKIQMLIDEVESELTQYTREIERLGKLTLKLSRQRAELERYQREHLTLLSPVRRLPPETLTGIFEYYCELPISIQRDTIMAPAVNLSHVCSFWRELALSLPTLWSSLRVDVGTGSDITFGRAQLLQHILVHSGSHPLTMDLKIQTRWSRVNPLFMHALVQHSHRWETLSYNPNSQFDFTTPSEAPGGLILSHLKSLTLQYGNCTESQFGQMFKEAKALKHLCLEDVFFDTESDFSAPFVTLVPCGQLTSAKFSRQTVPQVMAVLLNSPKLESMTIDNSYPEPPAGWGTAGNPQSLVHPTVQLNHLTSLTISTTDLEGWFTRLSTPALTSLTISPPWSPHPDPNLEFPQTVFLEFLRRVSSTSTSSDLALGYDTEESICVLEELKFDRVNSLTDLQLLAILELTPSLKMLMVREWSPSFSSPPSIPPSPDSKSYGNTAISNYLIRALTIPQQDCVPAGLASPSSSASQGTGYVHDSTSILVPKLHTIDFVAKPSSINYGLLVDMVASRSQPQMFSTTPGSGLTTGASISPIRNVSVRQGWLPYPVFDEPQGHFSRPLVALEPIMLDFEFADASETNGNTHFVDHPGRGPDPCLLADYEVAYRRAGNRLIDLEDTQAAEEDAEPVGKWIGVVQKIKEKAVRSLWWGGSITTPDFSFVRLVSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK59</accession>
    <name>A0A8H5CK59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK59"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="292"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="524" mass="58447" checksum="AE1843209D3090FA" modified="2022-01-19" version="1">MIGWEISHVTPMSSSGPHVDLPYLSYESAGSKSNVIAVPRPRATGYTAAHQNHMAQMDLWHSKAYAASGETVSVNVTIGYLEEGKPKETILSGLTDSIRDLDANATVPEIRAVVVNLMRSKIDQITANVPKFLFNFQEINLRETSNKLQVDMDGPTLDQHQPYFRPACMKEDKKTHQRKFVQPPMPFCLILIISVEEWDRYQSALEEQECKKTLPPPITVTSSMTSCPSSRVHTQGNSPQSIPSTTWTATDFNCNTNNASPSQEDPNTLSLSNSKLSLVAPVPKVSFLDIIESDTVNSRFVFDNHVISSDAHLWVDLRFESELGVGAFKMCHRATLICSEEVMPASNSIVMKILYKNKGTRMNGKVVNWGRYAGVDEFEGIIIEANVHYHAVALMEFAYAYIEHQKQLKGPPGLPIPNLRYVEAAVFVVLSDEIKHSRSCTIGPKHTYLLEERIAILPGQDFIKYIHNSNPVHPIAPDHAKYTTALFLVAVQHLQYEKTHENAYVSDFQGYGGLLSDAQIMTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKJ3</accession>
    <name>A0A8H5CKJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKJ3"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="630"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112465" checksum="834F53F92DAD3D84" modified="2022-01-19" version="1">MVSSLVRTTTTATRSSLGGKKAAKTVKTVQPRILGRLYHDESFGYRKPPAFAFPDYTEAQLQNRHANAALLRYVDSVRMHAHRAARIDPLDLIDRESEVAALNPGRYGLPVDDPEHQFNVNGIIWTHPNVSEQRGSEQELMTMDEINRRLREVYVGRIGFEYMHSPSKTERLWFSHLLESNSIPASAFQSHKLRKRIHGLLARSEVFDNFLQLKFPNLKRYGLEGGESMLPALDSLFSAAARASLSHIIVAMPHRGRLNLLTDPELLKYDPTGLFYKIRGGAEWPEELVGEIGVGGGVEGDVLSHLTSSANLHYPNTKPLKVSLLPNPSHLEAINAVALGKTRAKQYSLLRTSPETCQLGDRVMCIQLHGDAAFTGQGVVMETLGLSGLPHYTSGGTVHLVVDNNIGYTTPIAHARSSQYCSDVGKMIGAPVLHVNGDYPEDVFRAMEIAFKYRQYFRKDIIVDLLVYRRWGHNELDVPNFTSPLMYEKIAARKSVPRIYEEKMMSDEILTQEEIESVRKEYRTHLDSALVALSGYKSSLSDSNSPVSSSSSSSNSAAPSALRMKSQWSTIHWPTSPSAITHPSTGVDLDVLRELGRASVKVPEGFEVHEKLKRFVKGRLGSLEENGKGVDWATGEALAFASLMLEGNDIRISGQDVGRGTFSQRHAMLVDQRTERVVVPLNEFLPSPPNSNDERVGKLELANSSLSEMAVLGFEYGASWERPDLLSIWEAQFGDFFNGAQIIIDTFVSSAETKWLKQSGIVLLLPHGLDGAGPEHSSCRLERWLQLTNDRYAHNSSPNNHQTINMHIVFPTTPSQYFHLLRRQMKRNYRKPLIVAGPKALLRLPAAASPLEEFAQGKSFKPVLDDPIFEPQSQSTKQAEVKRVLLCTGKIYYELAKERKERGLEDKVGIVRVEEIAPFPFVELGDVLAKYSSRETDKEVWWVQEESRNQGVWGHVQERLRNVQGLEAVDVKYWGRKESALPAPGVGKMYKEQQERVVKGAFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL45</accession>
    <name>A0A8H5CL45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000135">
        <property type="protein sequence ID" value="KAF5343730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL45"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36192" checksum="98FFBB296226A90D" modified="2022-01-19" version="1">MYHISFTRLSPMPPKSSASTRAKWDGTSEDILIEGVKGAVASGVKADKNFKPQVYQAISGNLNQAGYDFDAQQVKSHWNRFKASWKTVNYLCNLSGFGWDDEKKCVTATEDVWRNLLYNKQEEKFDDYNYFKTHNFPYYDDINALIGDSAAQGDLVFLSTAGASASTSTDPEANAGAGVDAGNNNNNPTDANQPEADDSGPAGDVDALPPYTLPTAGNKHNNTPPVTPVKKRVCPSSGAQIGQLVDCVDKLVSGLVSPTKGFTPHTQKSRKDLAWSTIKKEEGLSPRSLAKARRVLNGGDDVVEDFLSFDAKDEDECMARSFWLADEMDNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLU2</accession>
    <name>A0A8H5CLU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLU2"/>
    <dbReference type="OrthoDB" id="3270804at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="319" mass="35909" checksum="FD89A6C43FB17F13" modified="2022-01-19" version="1">MSEICTTMNTKNLAEMALDMISDLEQSLETHMVRHMLVHIHSDSDSDHETLPTTIDSDDESWEQLSDLDMEINSYQTSRPTCTPQLFGHRTKETEEGKQPLKRAKFYNVYTGDGAGTYRDWSEAGARTNKVSGALHQSFQSWEEALEAWKQYCLSHHDHPSDMQDGTVYIPVQSTPQPRSVSPPRHSVRAQSIAPQHVPAPSTPTQLAGTSTRRVAESPQELFSSSQSRHGSPSKKRVATAFYGPESPPRQPVSSPRPPLWAKRIVVFNREEVDEIMREAARRGLRTQQREVDSIVEASEWFSQLDLSTESSSVSDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CML2</accession>
    <name>A0A8H5CML2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CML2"/>
    <dbReference type="OrthoDB" id="2751465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="40151" checksum="E111E0F489E3977A" modified="2022-01-19" version="1">MALSLSGTFIVALFLESILYGAYIILFVASLTIIWARYKRTKELNKSLLTVTIVLFTLVTWHLIVETIRLISAFKNPTTAEADIFYANFTTTLSIVETSLFLSVTTLSDAFLLYRCAVVWGYYKPLVAFLCLVFLGDLGCGIGATVQLKEVDASQTLFVATQGPVTEAFYALTLSMNGLCTGLIALRIWLNQRELAKAIGSMAPMARLNQVTIIVIESGALVFATLVMSEILYASHQLQPFLVFFNITPPVILNIITAQGLAFSLILVRISLGFTPDGTRRDGNLSRVRFRGKKSQTLPPTSAFELQSPIERSREKRSSTIGTPDTKTTATFNDYMFGEEGILTSQWKEEKETEEIHEAQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNZ1</accession>
    <name>A0A8H5CNZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_008866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNZ1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5344077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="159" mass="18242" checksum="9EFDE547DAB911CB" modified="2022-01-19" version="1">MITYILLVSRQGKVRLSKWFTTMPLKAKAKIVKDVTQLVLARRTRMCNVLEYKDTKVVYRRYASLFFVCGIASGDNELVTLEIIHRYVEVLDRYFGNVCELDLIFNFQKAYAILDELIIAGELQESSKKSVLRVVTQADSFEEQESSDDMIARLGSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP20</accession>
    <name>A0A8H5CP20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP20"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="189" mass="21260" checksum="14F816E79809D8CF" modified="2022-01-19" version="1">MSHWTQYDEDPYRLPEGMRRTGYDTDTGKYKFVDRHGKVYESAPHEYYGEMKPASVSAPERVYVREDPAVINERLQGLFEPKKPARSSTLPSSSFGKDPEKESFSQSDDEGRSVQEKSRKTGSNLQAGLRSGLSRSKTLGRLGLAKLGKKSLSSPAEEEPGSPKSTVESFTSTTTLLRRYTRRATKERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ67</accession>
    <name>A0A8H5CQ67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ67"/>
    <dbReference type="OrthoDB" id="2920504at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034584625" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="13688" checksum="FAC6C4C65091FC97" modified="2022-01-19" version="1">MFPSQYLLLLTFPLAIVGVGASTILPRQQGCTLNPAGKGVSIQIPVNTSTDFPFLELATPSVAPDAFLLAVNSVHGFAQPDFHLQQNGQANPSYIITDVSDNSLALTYIGFDNGDRLTLEPISNSGNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQX4</accession>
    <name>A0A8H5CQX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQX4"/>
    <dbReference type="OrthoDB" id="2576233at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="102009" checksum="CB49AA154F2A090C" modified="2022-01-19" version="1">MAGIKCLGCGKQFSDSGYSSHINSTTNAKCKLEHRADQPQPGQVDSGSSSEPKPYSHAISSSLFERIHGRKPIARAVAVDPQGDFFGTHANLDMDFEMLDSQAQDIMEDGVIFGLGGREPDLESLDEAGIDLDEAEMAAEAALMEHSWEPEVPDYLKQYCSPPGSPVNFLSDEELEDAPSPEAVLSDSDDEFEEFLNVRHEAEKSLMKNPFIVPYPDPSAGAPLNHTTLKPENVRYLEALRSGKSEENFWAPFKSEMDWQIAKWAKLRGPSSTALTELLKIPGLVEKLELSYTSANELNQIIDDKLPSRPQFRTANIVVEGESFEIYFRDIMECVEALFRDPKFAPYMKFVPEKHWTDSSKQTRMFHDMHTGEWWWSRQVYLDRTRPGGTIVPIILSSDKTLVTNFRGRSAYPLYLTLGNIPKEIRKKASSHAYILVAYLPTSKLEHISNKAARRRAVVNVFHSCMKHIVKPLESAGSRGVSMNSGDGLVRRGHPILAAYCCDYPEQVLVACTRYGDCADCEIVEKEMGEGTKLYPVRNLAKILHALNSMENEGPTEFVAVCKEAGVKPVFDAFWKDLPYSNIFRSIAPDILHQLYQGVMKHLKNWIFEAFGKEEIDARCRRLPPNHHVRVFLQGISSLSKITGQEHNEIARFLLSIVVDIPLPNGFSSVRLIRCVRALVDFLYLAQYPIHTDKTLALLEESLKLFHQNKTIFVDLQIREHFRLPKIHFLNHYVEKIRSLGTLDNCNTEQTERLHIDLAKDAYRATNRKDEFTQMTKWLDRQEKIHYHDNFLDWLQHGMPPILHNPNWLCSLFSMTRTLQMAKHPNTCVHSLIHAQKTNCITFFATSLARYIALLRFPSPSSTRHLGSLADSEVDIDIVSHVSSFNVIKFIQTDPITGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT76</accession>
    <name>A0A8H5CT76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CT76"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="3">
        <location>
            <begin position="268"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="39611" checksum="DDF1B59D95B81CD5" modified="2022-01-19" version="1">MCLGGYLPDTWFPILTSSSLGPGTALTTSGRYATPSSVSESAPSSPATSPQPSPEPGFDCSSHLHGFDIYDRTDCHHHRLEEYWDCETQPCPHAYNNPLPSLALFVDETGESHLVIPTRRTFRPIFTTSPEPSSPLPPVSPVPSSAVPTARPSPTIVHVPSPLASAPLSPIHSPIPDIDMSSAALENLLQALINNQNQLQQAVTSLVNRPTHEASDKTPKPAPFKGKPAKLDSFLSLFILWAREQKRLKLDNGKLDPQKCIAEALLMIEGPAAEWAAEYARHISRVRAEEAGAVFPWEGNWDNFTHALKVWFGVANEQQLAQNKLEVLKQGDKTVSEFSQVFKQWAEKTGFSDKDLQYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTA2</accession>
    <name>A0A8H5CTA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTA2"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034536943" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="28399" checksum="06CF597443B4FA39" modified="2022-01-19" version="1">MKVLSHFFALLHYLSIYVVSVPTPSNDVDINPYPTKPRLTFRQDGTFKITVFSDQHYGENPWDWWGPEQDANSTRLMKRVLPDEKPDYVVLNGDLITGENAFKENATLLVEEVVAPLNELKIPFSTTQGNHDNQVNITHLAEIKREQLIAPLSYTRIAPPGVGGDPEQGPGNYWVPIYASKASRSPSLILWFFDSRGGFAPANSTNTSDPVEVEDWVHESVAQWIEDEVALMDKAWGPSEENRAALAFVHIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTU5</accession>
    <name>A0A8H5CTU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTU5"/>
    <dbReference type="OrthoDB" id="3063557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="593" mass="67958" checksum="0188E2A8817744E3" modified="2022-01-19" version="1">MAQIFSDARDCSFSNSSISCMTGDQNIVYGSQTVINHSYGGRRRNRDEDDYDGDAEEVEARRKRSRLKALMDDFREFKRGDTMVLELISGKNSEFNNMRARRRIEAVKIFSNETRNEKFTSVTFEGTEAQEMWKDTFEEFSRIRSANSWQLFGFTRSQSYPSLIFHYEEHVSFNSVYSRASPIVKVFLLYRLKADVDHLRDTMDVLMFTSEAWVVPEKPTLNYGPPEEGSEGVDDDDYPYFHSISVLKPFPGFWREEAVIAYLDTAAVEFHGLLTDAGTGFYDEVSFCDCDHTDIMPLGQLFLTNRGSAVGGIPLTPTWSKIRQWFKVGQGSEDVDCSAVIMQNGWTRVYHPCNQYMKNPSLKESIEFRAVVEMTEESRKFLLSSWYSQAPWVFKQIGLDMYQHGRDLWICDSIESQITLHGHDSLLLPKDIFVFLPPIEQVGAASFCLKGDPFLSYDECGETRIGCSRDDLLGLVSPIQRWCFGCMLRGRDPLPYIASSYYQRLKGYNPDTNAYAAAHGFPIFQFAPNFKEIIINFVKKMGCYEKTKINPDGGKDGFLLPLLDGHASHSRIEEVDEEVEVEEYLTTETEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYF2</accession>
    <name>A0A8H5CYF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYF2"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5350205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="39614" checksum="70DC03C9F8E8257F" modified="2022-01-19" version="1">MSDGESNAMDVDPIPSSAKGKGKAVTTQYTEDETLPWVEKYRPVTLDDVVSHKDITTTIEKFIEKNRLPHLLFYGPPGTGKTSTILAMARRIYGSGYRKQILELNASDDRGIDVVREQIKQFAETRTLFSKGFKLIILDEADMMTQAAQAALRRVIEQYTKNVRFCIICNYVNKITPAIQSRCTRFRFAPLPITEVEKRINTVIEAEQVKLTEDGKKALLKLSKGDMRRALNILQACHAAYDMTSETEIYACTGNPLPSDIETLVNSMLSDEFSTAFKLISTMKTERGLALQDLLTGAYEYAETLDLKPHARVYLLDNLATIEYRLSTGGSEKLQTTALLGVFKNTVELTTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D223</accession>
    <name>A0A8H5D223_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_009189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D223"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="60"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="155"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="714"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5352205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="744" mass="81957" checksum="919FEF39EFD54CF5" modified="2022-01-19" version="1">MVVEENTIVSEVVFGETSSGAAMVQGSYVAQGASHARMSGPYGNRGSGESREQTIANATRKIQSIANILRLSEVVCLSATRLYTLAVEHKFTKGRKSLNVVAVCLYVACRQKETRNYMLIDFSDLLQVNVFELGHTYLQLIQTLNLRLPLVDPSHYISRFAALLEFGDETHRVATDAIRLVQRFDRDWMTRGRRPAGICGAALLLAARMNNFRRSVEEIVQVVKIADTTLKKRLDEFKNTPSGSLTLADFRSVWLEEEVDPPAFTKGREKEEAEKEAQREKEAAGSEDESDSGTEARKRKGKGKQKKKKKGKEKRKEKEQEKEKEREKKRKGKRKREDDEDNAEDLDQDAEGDVDEDVHNESEAGPSTAAARRPLDPAIFNDSESILAGAIDSTPLFLPELEPEVDDSNIDPALLDKSDEASPFSLGAVSLVLTSPNSLPSIALPSTSASASTSTSSHTDQEPTHPSPDKDSDTDHSDLKHPELVPPPIDPFDETVSTALAEEVNTFLSSVQGAQLTDALNDAEQQRLAEMEEVDELMGLDEDELDRLLLSEEEVKIKERVWVELNRDYLEALAAKGDSEQSSSNKRKRRKTSHNNKPRDTSTAHGATAAESVKNLLKKNHRYSKRINYAALQDLFVDGPGGGPTPNIDDKTDEPLYTMDDDKDDGDGEGEGMVVIEEAGVVGVNPNPHTNGVGVNGSSKSNGNGNASRSTVPMDEDDGDGEDEDAEDEKDDGLEWDEGYEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D275</accession>
    <name>A0A8H5D275_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_011970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D275"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5352280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="527" mass="59084" checksum="1F2D7DF13D6F1990" modified="2022-01-19" version="1">MPPRSTPPPKSSFFPPYDNATYRDLLLFEERLKITAASLQKRKKKYQLFLFQLLAIIAFLLYEVLAPPQSSILAIPYTLLLQKVLPEIYGPGTGYGLGYWSSWMSSDDDNGAARELVPVHPFLTTGLLFVSVTTLVLFFASGMYSEKIGYANKYVPHANKALRSFNMYLNVRKPPLRSKFYWNPMSFFFPRPEEPSHSHARTGSRSRPSTPSPSQQRPSRSSTPRSSRSPSPTPPSPSSNSFHDTQSTHPHPYSQRRSSSSSSSHETQPIHPYPYPQRRSTTPSKSLSSFPTQTPLPISPIPPAKYPRGELIISSKVDKSFRESYERYRAAFERRREEREREEKRKKMKAKVWRVVFFWRKQDEEESNHTHTRTVSITSTSSIGYDTQRGMRLGTISRGGTPPGSAGLGPGGRQRSRSRQRSGTPPLSPGLVPSPPSSPSASGSGSGSASVSSSPGSPGRRRSDRLKTQSQRASLREVRERMELNGLGRDGDGDRGRERGRERDMNVDRDVDMRTLALERSLGLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D477</accession>
    <name>A0A8H5D477_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D477"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="131"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="537" mass="60620" checksum="6ED51204BC34360C" modified="2022-01-19" version="1">MKKFFSAKPKQQEKDPIPTTTPTQQHTPIHQQHAAYRDEDDYHLVETPPRSPSPGPKSQQQSKKPAPVLGILKALDPDSPIEQTDHSRRDVKWFAGWNRDRDREKDKQWQMVDKDSTALTRMIGFLTATSSEDWALVLEVCETASAGETSAKEAVRALRREFKYGEPQAQLSAARLWAIMLRNSSDTFIAQSTSRKFLDTLEDLIRNPATNPVVKERVLDVIAAAAYASASKKDTTGFRGLWRRVKSLDKPDEGIPFDTDDAMFNPPIAGHRGSYYEGQFSLGSAGQFPPGSIVPGTTPNLSTGTLPITQIDTLPPKETQKDNKEKDREKSERKHRHRDHSERERSHKDRENRERERDKDGHKDKSHRKKEKKSTKDKIIPLEEDIRRLFQECKIGMGNAGLLSQAVGHTKPEELDLEGDGKDVISEFQIKCMSSQELIAAQIPWASASADKSRREREREKILLYAQDTEHVRQRTVSQSSVNVIHALSPNLGRTGSTASIPLSTTAQGQDDFDDEQTTEERLLAALLEANEELLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D546</accession>
    <name>A0A8H5D546_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D546"/>
    <dbReference type="OrthoDB" id="3237066at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="83290" checksum="9B46BA5DF381E5A1" modified="2022-01-19" version="1">MATSPIQTLPVELLSYVLELATHATLGQNSDYEYAFDVASVKAPLVYSAVCRHWRIVALGTPSLWTSLCVTMGSLEDNEEEESSHNSKQVLDTRHLDTYLHLSRKCSIDILIDARDPFWDFYEPEIPSTCDRDSDDGFDSESSSTFSLATIHIISSIVLPHLSRWRSIEILTDTWLPMQTFLSRINPPLIEIGAPKLEYLALMRCNDFISHSPWFEPREGKGMAFLSRCSRREDVSSPDTVQPKLPGLRSLVLRGVHADWDELGEVMGTELKTLDLSSHSYDVRPTLYQIRKMLKKSPTLTKLVISGSGVVFSSSPEGVVSKRSGEASNLGMSSGQGIASPASSHSRAANSPSLIQPVHFPHLQTLHIGYRSQSSHVTDPLETDATRFMSILNAPTLRYLTLEDTSHPGDEEFVDAGELLGLIASGPEPTSPGTRNRAASWSEGVPVQPAPQRKFPILQKLSLVGVKATYESFRNFFWNVDGPLVSNANDGCGLGLQELHLDRGEVLEHVGGMDLLAGLAPSSPSHFGSFNPSFSFSSAASPPRRFSESNAFPYPGQLAQNAPVNDVPLCPPKLLHPCPNLQALFIRSSAPAVPNDFEYLIHRIISSRSEKLQNVDVRLPEDAFYGSVGRHQHNTSSSVNATSAVSSILNALAVSSKPNPNKAVSQNDTSTSTSATETNEPEDSDASIPNLIGTWLVDETGRATECTPSPSTSSSPSTPCSSTFAQRRTLLRIFKPKPMSFDSYDAEAAEAEAEAEAFRYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8F8</accession>
    <name>A0A8H5D8F8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8F8"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="264" mass="29471" checksum="A1DB917C2DE7998C" modified="2022-01-19" version="1">MPGQIKSNGVNGVNGVNGHHLNLNGSGTDGPIHPLRRSIKYHIPGGDLYVVVDDTQFRIHSYFFTRESSKFKNALSQTTLNGTLGSSSATPLFIHNTTAAHFEEFLWVFYNESYSIYDAPVATWARILRFANRWDFPAVRELAIRELEGKDIDLVERILIYQEQDVEIALILPLYNALVAREAFITPQEILRLGYPTAVMILQARERLRTLPADFINGINPLRTGVGLDDAGKVVESLLVDFPRTAPLEVSASSPLTPRMNGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EWD0</accession>
    <name>A0A8H5EWD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014913</name>
        <name evidence="2" type="ORF">D9758_018831</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000504">
        <property type="protein sequence ID" value="KAF5314789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000213">
        <property type="protein sequence ID" value="KAF5337610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EWD0"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5314789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16247" checksum="C67525A709D38857" modified="2022-01-19" version="1">MVCSCSTRASMPMSSVAASASTSSGTDSVVYVFALNEGSGKLEYKIGSTGRTPETRLREWRRGHQSKGFRLVYSVKVVGRNTAYVVEHEAHQQILQYATKIHRSCPDCLVVHQEEFVMELDFGLEDVRDAVDTAKRLVETRRVGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F159</accession>
    <name>A0A8H5F159_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000425">
        <property type="protein sequence ID" value="KAF5319874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F159"/>
    <dbReference type="OrthoDB" id="3066004at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5319874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20536" checksum="584FD298DB89FCFF" modified="2022-01-19" version="1">MRVQRAAGSIGYDKYLTTAPTSVADQQQQDKDLLNGIIGKLPDTIFRHYKNKPTSKELWDALKQDYDAKDTLTEASLEKQLFSLTCTNTAKVGKHLDNLIAIMDELANRRVTIPDSQFKSAIISSTPDMYQATVKALITVYREKPSKLTPEMLIAAIHAEAQGKNFTSSSNKSQESVNYSNDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F993</accession>
    <name>A0A8H5F993_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_017325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000360">
        <property type="protein sequence ID" value="KAF5328495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F993"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="460"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5328495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="654" mass="70738" checksum="FD9387C1D34DB52B" modified="2022-01-19" version="1">MPYTASSVFLKSLAAAGITHAFVNWGSDHPALLEDLQRQRTESEHRGQTLPRIVTCPNEMVALSAAQGYAQATGRPAAVIIHVDVGTQALAGAIHNVDRARVPVLIYAGASPFSSLRELKGSRNEWIMWMQDVPDQSSIVRQYMRHTAQINSGRTVTQVVNRALQIAMSEPKGPVYLWARREVMEEELPDSFYLSLPITPRPPLAVSPSGLSAIDVTALSNAFISAINPLIITGHLGRNQDAVASLVTLSTLLALPIYCACPSTVNVPFSHPYLYGITYLTPTPDTERYKAHLENADVILVIDCDIPWLPLRFAPKADARIFILDGGDPFKTTVTMGMWDFSLHPGVEMVCRADAELALGQVLDSVKSSLGSMSAEVMREVSETVKGRQFSASLQHKEWIQALDEAEVVGSPATGQTQITVPQAMAAVREVTESYTPSETTGVRSLSTLVLNEAISNYPFVWEHIRPEKSGSFFTSGGSSLGWSLAAAIGSTLGIRTSEDGSPGSGGYDLTVNVVGDGSYLFGVPTSAFWIARRYETPFLTIVLNNGGWKSPKLSMLGVHPSGHGSRSFSGEQLSVGFRFDQDNDTAVIRECPDYSQVAVAATGGWAWGKRVGVHKEAGLESALQELKATLKEAVRIVVEEKRCAVVDIVLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAV6</accession>
    <name>A0A8H5FAV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000333">
        <property type="protein sequence ID" value="KAF5330104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAV6"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUF659" evidence="7">
        <location>
            <begin position="279"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5330104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="820" mass="92309" checksum="F481A4167F5CA04B" modified="2022-01-19" version="1">MNDTNDSVAEVRNPQKPLTGLLFLLVKIVEESWELPERLQSPQLVAGSALFSKITQAGNAEKLVTNQAEIAVIASQDAERVESGQMEVARTAQQTEAEIVSGNTRGQTILCSANSTMLNHFKVCEYQTQETQNMANTKNATQPHPSAQPRTSPRRRSANAPSHVVGASRPPSHASFSHPSVVDLNSLLIAPITSEYNQQLPPDDTISNITKPIIASISDSYNLGWSDDQQRRFEELLIHITASAGLPLSWVDNLEFDAFVYEFIPGAKPVSWKTLSRHVLPNVIKQVRMNVATSLSGREVTLQADRWTGLNHMHLMAFMASTDTKIYTVDVFDTSKDRKTVEEFLKLIEKCYEKVTQGWGAQLVGFVSDASGESRKACWLLAKKYPELAVLDCFAHQVNLVVRDYFSKSKAQDLQFTDSTTELITWLRSKSLILAHLQGKTVIRAVLTRWTVHYQAFVRLVELRPKLLQLVHHDEGEPEERKQIMKTGNVAAQRKAQEMMEVIKNHIIQHLEPLAIAANVIQAAHCRLDQVLLTFGCLFYQFSHMDVADTCGCNAIVASLESRWHKTDQEIFVAAVLLNPIFCNTLFRLAGIQDILTWLWWRFYPQEPLDFEFSNHLDDYLHSRGFFINIQSRIQLELGNAEANLFSVFGNTLTKLRNRLGKQTLTDLTELKMHIRDKHLQSAASTWLKRRFEARGTRAAAEYEAQQSQLQEALTPEPPSNTYSDTGVQSDTSSSDTASSFRSMMERNVAAAAEDDEDNNPVIPSSPTFNQRWINMYLCRSKEANSEEMALYELLEAENVGDEGGLIDMDGTNEDLLVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDZ4</accession>
    <name>A0A8H5FDZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000291">
        <property type="protein sequence ID" value="KAF5333042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDZ4"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="769"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5333042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="103845" checksum="999CDF3CE147F7CD" modified="2022-01-19" version="1">MAGSLTGLLSRMRVPKDLFLHLDPEELDALFVISIFTTSFCTVDPETMSNSGTQNPIGNPSNFTTIQELPDDAKFNGENYVSWKESMEMRGKLKGLHLYWEGQVTEPKDLTVPEDKLQPTPVSSRKPNYLEYEIRESVAYLTIWDNVKNPDSLGYSGGKKSNELWKFLADEYTLEHMRLMGGSGGGGSIQGLDKTKALQAQVLELTEKVNALQTSRKGSGPANPDLLCSNPKCKRRGHTIENCFREGGGKQGQYPAWWKGKKDVPVPSANNTTASTCDDSPTILALSTTVQRTTTIPLPHDPIRIIADSGATHHFFRQKSSFITYSLHADKGGSSHENAEFDIVGRGDVKVEVMYGGVTYHLLFRDAFHAPNVSNNLMSTGTLDRLGWTAALGKGRMVFKQPNGKETFEAVLDGGVYVMDAKLIKPNTALAAQLPADIRYLHRASGHIMPERIEMAYDLVDGIPKVKGTWKVMGTCEDCRKAHTDKQAHPDSTETITEANFRWYLDIWGPAQVVSVGGHLYALFGTDAGTSRDMVDFLKDRTAATLIEKLEIRRATAETQTGKPLKSIRTDNAPEWRSQAFQSDGHWVSALEGENEDVLFLEPTPKPDSPIVAQTPINSDPKTPNPTSLTPLTPLTPTPATDSEQPIPNSPQQKRNRRTQAEIWGTVPTRSSTRSRNLTQDFIQSKEYEERESEAQDRGEEWAKDNDNTIELLPEFDEEDNPTAFTANLEPVIEPENTWVPNSYAEAMKRPDLWMKPMEKELMKLDSRKAFTPVPRPKDAKVITTRWVYALRLDGNGKITERRARLVVRGYDQVKGVHYDDTWAIVARYESERFAIAIAAYEGLDLWSGDFTGAYLNAKPQGVNYLTLPDGFQDRYSLRDGNETVLLMNINIYGSMDAGNNWFKLLDKRYREMGFKSNPADPCTYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLU4</accession>
    <name>A0A8H5FLU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLU4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="36498" checksum="AAE9B5A0CFC5EE06" modified="2022-01-19" version="1">MSGEVIASESQILGDRSSYTFANNGLRIHFPLAFTGRRYRGKPVLLASLFCQSARDGSYLYVYLQRTRGQQYVRCCPDELVFKHSPLSNPFYRVTDTWFRRLRYFSQLTLLPSSVHQVTVRENVTLRTVNNCQLKPGPESPVSACYHLELLPSAQHFVCASLPDKDGFDCTQLRNIISFSLSTRHEKAALIFECQTTGEAFSIQFEFNDHLSSFKLQHHSAKLSDCGDPYASVNGKLVRLDSGAHILAVEEIRADSKTCLEIEYIPRLDPEIEFLIGVLSPPILGFTAASKVGHGIFTIKVLLYLSIFPFMAILYYNRDFNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN97</accession>
    <name>A0A8H5FN97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN97"/>
    <dbReference type="OrthoDB" id="3225203at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="53731" checksum="E41CC0A06CAA9777" modified="2022-01-19" version="1">MVKLDWRERWVFIKDGILNVWKDREDATTAQYLPLSDLTDIRGADQLGRSLTISSAFGASSTLGASSTTTTSRPTQPGQPRGQSDISGLRGMLGSTASASSQRIVCAKFKGKLRDGSHKADEVKEKRASMSLDPSHVSAYAHGRTSASAPQSGSVPTGSSAGGRANTSRSSSKQSSSNAKQPQSLPSGSPPTSNPASLPSSPTLRPQISAPISLRMQENQGVQGDEGKDSVIFRPPRASYPYIKDKGKGLVTAPVESPSAVTRPGGIRPLPSLPSTPAYPGHFDKVSDSKPDVKLDGKDNQDNDSRSTTLGVHPNFDNELVDEDLTGFSSDGSLSSPVFAHSDDDSDDSNTRRGYGYGFNERKKLPKVERDGEGRRLSLGAPKDRTASCETKADEKRGQGGNEGESDNAAGEADSSYVYVEGNERPSIRPRETTAHSTPRSRTRTREKESSGEWIVLDLRDDHAFRSFFTSPPSICSSYSAIYLPLPASLLHSTRSDHSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNM2</accession>
    <name>A0A8H5FNM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNM2"/>
    <dbReference type="OrthoDB" id="5803672at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="105669" checksum="690E07D9A08BF134" modified="2022-01-19" version="1">MITSAALSPKDCLSNRTLVGVINCLNDFTVDPSVYNASSYVEAQPSPEQVNDWTSLITSMLESDSNRCLISVPTTLSSIYVVASFIDASFSKEYCILVEITSFHDRYSKGWGVMVVPAMKRTISRTIHLSAPHPLADIDTPQQAAAMFVLSGAHSLLVSGRHRMAFDAPTDCVKPANPNTTYFKTDPAHDVNEPFNVANRAIRAWQNLHGGCPLKTCAYLQIHGKAASTCPSDTMFISSGLEFDPPYKETPQRNSIETDPISLLAVFPNFTAPLPSDDPDCSLTATENVFGRLINGVPEARVCKHAANASTATGEFIHIEQAIISRQSSNYEGWGEVIRRTFETSCQDGMREDEGTMFWLVMHLPIRHTFLPTLLRKVMAKRGKNRKHRRTSPEVPIIAAIPPPQTFHLPPEITFMIMRKLNEGPPDRTWHYLVNASLVCRDWRGPAQSLIFQSIYFHSNERCKRFRKLVENNPRLLSYVRHLSILENDLVSDFDTVVSDRNGKTMYGGWKAYLHLPEAMECIPKLPSSVRSLGVYISPWRDSTVDTVKQFTNIKKLKIKFVTTMLAWELQTAVQNFHNLTHLHLCGSFPLLGEEHLESRRKSMMDLLVLEEVEDCFDVMQVLVDGDLFDLSGLEYLGLQWSSPHRGQEEEFRALDMLFEKSGSSLKTLVVEFYNTDYHTSDMYLAHLTADPSSSSLRNLTALENLAFKKIFLGELGWDAIPFHLASQLAFMRAVIPSLGSSAVTNVSSPSTLKTLTFKIAVDDSHYGYMPISQEWMVGINKEDPDCNWRILDSALSNEERFPDFVVLQLAAVVLQDTAGMYYSQRTAQDMQLDELFSEIKKCLPKLSEKKLILDYDDKLKGDEFFIDVEKKEEPILRPGRWPADFSESDSEDEDDEGLSAELPSAANSENGLANDEGVEDDVVEGEDGELDNLEGKSLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPH0</accession>
    <name>A0A8H5FPH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_013240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPH0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5344336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61252" checksum="36693E2B7DC908AD" modified="2022-01-19" version="1">MATSREPSVDSIGKEIEADEVRIETSEKEDGLPAPGPSTTKNVGAGDAALEILQDGSAHYEVSEEEDRRVLRKIDFWVMPVVLLVYFLQQLDKSSLSYTSVFGIVQATHLVGSQYSWLTSIVYLAQLVCQPISSYLLVKLPIPKFLFVNVFLWGAVVASTAAAHNFKGLVTTRFFLGVFEASVAPAFITITQMWWRRREQTMRLSMWMAMNGVTGMVGSLLSWGLGHISDRLQPYQVIFLFIGLLTVVVSPIVFFVLPVSPAKAKFLTREEKIIAFERVRANNQGTENKVWKWEHVWELLLDFKTYLWFSLLFLCTVPSGGIGAFGPLIIASFGFDSFNTILFNIPFTFLQVVVTLASAWISTKLKVKWPIIFCLCIPAIGGVAALLTLGRDKHERGKLLASYYVISFFTGLQPMLYAWSAQNTAGHTKKLCTTGIVFVAQCAGNVVGPQLYTTDEKPYYHRGLISNMICWIALSVLTVVTAAYLAFRNKQQEALRRRLGKAGKVVDRSLDSYSERKGNSEGNEGEARNDKAFDDLTDIQNEDFIYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ98</accession>
    <name>A0A8H5FQ98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ98"/>
    <dbReference type="OrthoDB" id="3241567at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="386"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="541" mass="57521" checksum="2F3FB80F94876DCD" modified="2022-01-19" version="1">MSIYSPGRRTVTPFYGPAIVPSSPSSGSSSGSLTHSSRPSSIYSSSPPSIYAPSNPGSRNPSPVSPRIVPPVVPGSVVGSPFPSGASPSVATYPIYPQPTPSISRSPSNASSRSHCSPVIVPAVVPPSNASSRSHRSPVIVPAVVPPTISSISSVRSESVSPSPEPTITGAAYQDFLSVPRGDFPGASRPRSASGGSPEIFIPPLPGEEPSAANTPDPVPIVDPSQAQSRAQAHAAYSPSWSYGAYPPTPYSPYHNPYYPPVPYPSAGAYTPHTPFTPFTPFTPHPHLSPYTQVQPPPQPFGISNVQNTPFLSTPAMLPGMNGNTTSTPWFPNTPLQPSFPFFPNTPHTNNLNPNLNTHFGAPAPLVYGPATPPILLHPHLTPGVLNWDLLHHPTTAKYTSQWGAVKSITDLLGEEAITMLPIPTQAGVRVTKIRITASSNPVLSYWLPIWTGGQGIRLPHHKLADILQVIYEFLHKPLTPEETNLLLGTPGNVFNAREAKRRRAREGMWSVAGAVEGEEGYRRMDCLGVLRGFGGFGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FS27</accession>
    <name>A0A8H5FS27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_011619</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FS27"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="13">
        <location>
            <begin position="173"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5347051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="848" mass="93926" checksum="B7C043389B6ABFAE" modified="2022-01-19" version="1">MRQYITSNFKQKAEMIGNRRAPGETLVRHWRVALSMMLVSTCTQTMVSLAGTGIVATERPETASLLHPSLTSIPNILSIPFSTSFVFFIFLSSTLYSLYPCSFSLVYLSRSLAVHSIFRSPSHSHPLRIFMSPSTTVLFASLFGLSTSLLTGAFPVESRSPLAEVITSCTVNGTAALTFDDGPYLYTKKNVDQLDAAGAVGTWFFNGDNYDCIYNQDAVDRVKYVFDHGHQVASHTWAHANLTTLNKAAITSEFSRTQEAIWKITGAKVAFTRPPYGETNDDVLAVASQQDQNVINWDLDSNDWRGNVNASKGYYDETIAKKPSTILTLNHDTLQPTSDEIIPCAIQALQKAGYKLVSVADCLGVPAYLDFGSAQSRDVADNLSVPVSTVRVICLFNSFYKSTVMKSDGSYEVVSTSLDTDSSPYIAVPSRIYTLSKNTSELPLARLRISVKDLYYMKGIITSAGNRAFYATYPARNTTAPAITRLTDAGAHIIGATKMVQFANGDRATADWVDYHAPFSSRGDENVEPSGSSTGATSIATLDWLDASLGSDTGGSVRSPGAVNVLLLSTVLDTAGYVCSHHYYTIMPQLMPVFYLTRSPKLFASFDKVWYAESFQSYPAFPMKLLVSDEFSLVSDEANDIYNPWIEKLRTFLDGEVVVLSSITNGLTSVYLCLRITLPKTEDAVRISTRRSEIDRALVSSKEQMGMQLKWRRERCLDLDSFLENTESCTKNLFLYPHVFHRLHWHYLHTHIKRKGSIRGHIVAEKRIIPLPPNLPFGFRNIRIASLARSVEIVIPIGQIPYQSNISEIEEQLSVSISLVGRRGCDFDVDKLADEGIVQEVKTGRTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSQ9</accession>
    <name>A0A8H5FSQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alcohol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_011281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSQ9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="11">
        <location>
            <begin position="491"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="610"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5347382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="68936" checksum="1C87746798E27918" modified="2022-01-19" version="1">MSPLALQLTVAQSCPPTLTDAGAFALQEYDFVIIGTGPGGMTLATRLSENPSLSVAILEAGPLRVPDDNVDIPGLDARVIFTPEYDWMRGTVPTEFTAGRSIPAPRGKLVGGSSATNGMAWSRATKEEHNTFDLLNNGSGDWTWDTFLPYWRKVENIKVVLLFQFSRTRRLNFFSKLQNENATVPIPNLLSNDIVGNGGPMNISLNKVYPDSIPPYLQSIQAMNPPVPVNTKPMSGDTLGIWNTLIAVDLDTGKRNYPATSYYCTVAGRPNLHVITGAQATRVIFEKDLSPLKATGVEFSSQNSSFIVNATREVILSAGVINTPQLLELSGIGNAKLLRSLDIEVLLDMPGVGENLQEHFYIGSTWEILPNITTFDALKNPDILSQQREIFDTTGGGLLSATSSIIAYLSHRMLFDDETVQKLRDLFEDSLSKIDPATLTPLAIAQHQIQRDWLARGTIPEFEIIQINLGLVNADKSGNKSYISTNCGVQHINTTDPLASPAINGNYLSTDYDIQVLVEILKWNRRLATISPFADIIVQQTGPTPDVTSDEDLKQYIRENFSVGSHIVGTASMVPPELGGVVDTKLKVYGTTNLRVMDISVWPMELAAHPQATVFAMSERLADIIKGELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G170</accession>
    <name>A0A8H5G170_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF2421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_009464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G170"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="9">
        <location>
            <begin position="443"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="10">
        <location>
            <begin position="757"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="8">
        <location>
            <begin position="896"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5356418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="130003" checksum="D5EDDE51DC42C3DB" modified="2022-01-19" version="1">MKRGVNKEVKLNFPDDSDSSGSSTERSYTKTLNISDFLKVPPQLRWIADNCTWTKIKIVLRCAFAAWLASVLFVIPSVMRYMGQASFLILLSSIMSPPEGPFLSVFERETLIITFVAATWAWSCLGMKLADLARVHKDPTVPVVTALSSGQYIEAAPTVIIAIFIFIGTVVLLYIRARKGPGPYLFACIFSCICLDINLTTSVLIPYPYYRLGLNILKPLGLHSVIALVCSVLLFPQTVSAQFTTRIQDVLAPLAASIDLHRKLLTLSFDDPAFVDSIKELKELVQNSEKSVVPLAISGRLLRSDLIYSRFQPTDFKPLHNLVRRMAVRANGMCIYFTLIDPTREKFPVTPATSRPGTPTTVRSRAPSLSLSQTPPLQQSPSDREPPPLSRIQTSVADHDDAASTLSHTTYTSPNTPTTPTLTLPRDDRNHHRAHHSHSRSHSLHHHHHSHHHHRHHHHSLLFNALSHISTISLPRHHRQEDQAVGVFESQRYMDLEAKVFSDPLSEMYTERAKKLLSESCDGLLEGCKEALVKMQEWLANSRKGRWSFWKKREVKEEEWKKRVKDLEDLRAKMEELLRQFKQDNRHSVLEPYRSAFEPKMEGEEEEEPPAHRYLFNCYVYQYHLMRFATQLKEMLDHIIRLEHERRVNRLWTLVQRLFQWSDWELDDHGVRHDDEDPDKIQGITPAVEEDLGMPKKRDPDALPPKNTPEFIARGVYKFVVSLGGGNMLYALKAALLTTVLCLPYFLQQSAVFAYKNRFIWGIIMAQLTIARFRGDTTFGQVTRILCTFLGGILGMVIWYIASGGGGGNPYGLTATLAVCWPFLLFARLYWPGPPMQILIFLMTTGLVVGYSYQDGIIVLPSNPGVGWDVAWRRFVLVSSGVTAAFIFSFFPPAFTIRRYQRTTLATTCAELGTLYCAILSYANTRNEDESQEIVQSLIAMRSKLNRSAAIKTNVKYEFSLRGRWPEKRYQRMLELQMELAYCLSHLLSIVEHLEPAWIQAFLGRTRFIDPNFQGDILAVISMISTALRTGTPLPQITPCPLLDRFLLKYHGLNVIHREAEEDYGLPRNLTKETLQNEQYMMFCVGVSTAFGIVSRLDKLMMAAKEIVGEQYHIHGVGVMPSMRGVGVPLGPRTSTIAFRPPHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1C3</accession>
    <name>A0A8H5G1C3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1C3"/>
    <dbReference type="OrthoDB" id="2745898at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50849" checksum="785D24DACC26EE79" modified="2022-01-19" version="1">MDTGSPSLTPEIPQELVEKIIDYTHDSLPTLKSCSLVSHAWVSRARFHIFCDIVMAYPQRQGPFWTRDEYLEAQATIYRRLECLAHITSATRILPSMPQLTHNLVIDATIPEKVPELFPSLHPFRALRHLSIYDRRQPTDFAFPPEIFPDTPEGLNPEPLRSFLEKLPDLRSIKLRGLFILDVGTLFRVFQGIHLPQLKQLTLQCFDFYVHHAYDDSVTKLKECGHPIHPNRTKLEVLNLEVDVLRRQAFFKFLMHPTFPLDISALQTLVIAPIFDDLENYAPLFIHCGSSLSRLIISLTDLQAESVGTDAHSPACLGHLQNLKYLELWIVPSSQSAIDMMAAAVESFVPPLRLQIRGLSIGLHDWKGRGVLGDESILHHSYVSLDQALVKCVGATDTVDPESSQREIDIEVSSSFGLNVGQVLEWFPRMQADSGIPELGVVLFDEWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1H0</accession>
    <name>A0A8H5G1H0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1H0"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="164"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="36533" checksum="0C17C66BBEF2CEE2" modified="2022-01-19" version="1">MGHYDNVIGGILAGTWVNTFLFAFQLTEVYKYCTRYPKDHFALKVIVSFLSVIDLFEVLASCAFSWLFAVSHWGEPNYLLEQRWPSPVFTTLSAINAVIVQTFLIHRYWVLTRRWYNAIFLVLLSLVAWQAGGQIGCGLVIFLHPKYEERGRVILPASFWLAAAAAADIGIAVALVWEFSRIKLTQKVTRAIIKKLIHRSISTGSVTAILSIAIAATFFDTPQSNVCTGMALFFGRLYSISMLFNLNVRSWNCKDHVGTSLSNASLPEINIPTLDTSAGQRCHHTTFSVSGIQVHSAAVIHTDGDGEIISGNVYDIHDGAKSVTKAPEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1M0</accession>
    <name>A0A8H5G1M0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1M0"/>
    <dbReference type="OrthoDB" id="5076166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28113" checksum="741368A6D652C670" modified="2022-01-19" version="1">MTYSANSCILRDINRTEHVKTYESGKTSTYKSKGIMENTRPSMISSVLYLLLPGTAALLLFTLSSGLRRRSLSFLRGPPSPSFILGHEHVLMNQAESSILERQWTKEYGTVYKVAGALGEETLIVADPLALQRILHTGGYNYPRTLDERATIKRMFGKGIVCAEAANVFQGEVHQRQRRNLNPAFSATQLKSFLALFQKHSQRLIQTWKDDLSSGDTTKVSTSKVYDLVAWIPRVTHQEKPQIQLHAICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2W2</accession>
    <name>A0A8H5G2W2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2W2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5357347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56025" checksum="0769E3F789B43A04" modified="2022-01-19" version="1">MILELLSEHKLLTALVLVFAVIGFIRSHLRLNLPLPPGPPADSILGNHWDAAFGYRRFEQWTQQYGPVFSLRQGFTRIVVVGRLQAAIDIMEKEGANLADRPTSIAAGETLSGGMRVLLTPAGERFKKLRRALHAHLQPKVVSSYGPTLMKTARRHMLDIIEDSSRHQDHAKRYAAAVVMALAYGKIPESYEDPEVQAVNRCLTRLGLTMRPGAWKVDTYPFLRYLPGYLEELRDGHREELGLFKGQLQEVREKMAKGEEVFQSFGKYLIERQGELGLSDDETAYLAGSMFGAGSDTTASAISVALMAATVYPETQRKVQEELDTAIGKARPPVFEDQDALPQTMAFVLESFRWRPVTSGGFPHKATKDIIWQNYVIPKGTTVIGNVWSVGRDPDAFTNPEKFDPQRWLKDGKVRDDLKSFPFGFGRRVCPGQHMATASTFINTALTLWAFKVSEDPKHPIDTLAFTESANAHPLPFKVNFEPRLGSWDQVKESFEAYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2W8</accession>
    <name>A0A8H5G2W8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2W8"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034067497" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19027" checksum="605E7451EC7896C2" modified="2022-01-19" version="1">MFLLKFACTVLLSLSFALSAHGAALTTRNASPAEQARYLQLHNTLRAQYKAPNLIWNDTLATYAQNYVNKCTWAHSGGPYGENLAAGYGNGYNINAAFQSWANENSTYNYNTNNPTPSHFTQVVWASTQQLGCAAATCNLAIFNGALDLYIVCEYYPAGNVIGYFGSNVLRPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2X6</accession>
    <name>A0A8H5G2X6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2X6"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="357" mass="39285" checksum="15CC09C5086C3B89" modified="2022-01-19" version="1">MQRSFFRAFSKMAPRTVLVTGASGFVGAHVVKAVLNQGYNAVALARGAKAAYIKKSGEKYGEKLRVVEVDDIFNGQIDKEIFKGVDGLIHVATPMPGKTPIQDIIPAAIKGTLNIIEQAANAGVKSVVVTGSMASLRNPENNFGNDAWNPLTKEQAVANGSPMAIYSASKKYSELAVWEWADKHPDVEVAVILPPLIVGPYEREFFDVQIDNQSISNKFMYSFLFPDANYPPHILWTDVRDLAKAHVNALNAPPTSSIGRKRILFANPHEVDNKDVLEILAAKRPQLKDRLNKGEPPVAPLKKLPLDWKRVEEVAGLKPADLRTVEQTLLELVDDYLVSEDKWKAEGLDTSLKIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G306</accession>
    <name>A0A8H5G306_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G306"/>
    <dbReference type="OrthoDB" id="5372118at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="343" mass="38818" checksum="DA4C710546B055CA" modified="2022-01-19" version="1">MPSRNFEFTAAVYYKASSLPPEVFAAFEQNPVTFNCILPHILKCLKLEEHGRVVDGQCWIVVTTSNPEPRVDFVLSCTENEMGKYPIFIASTSPPPSLSDDFVHPRLHLIVEHLLDVVDLHRVYSVFAPDAVAYWFARLWTEQTGIRWYNNPYYAAKLSVCCSETFKYRSVTISPGLQHILRAADEHDLHAVAQLCYKFAQESEPFILDEQGALDEAAILIRNRTVWIHEVQQHNNAPIVASLVAFTRNSATVSTITKVYTNPDARGMGCAQRLVRRVCKHLFSTERKEKVALYVAHNNLAASKVYHRVGFIGLDPENSTPSPEVESWTEIGFDRAAVELGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3C0</accession>
    <name>A0A8H5G3C0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3C0"/>
    <dbReference type="OrthoDB" id="3172239at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034224402" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64460" checksum="CFBFB0856EEAB46E" modified="2022-01-19" version="1">MTLRCFKASRLVIKALELLLTLHSDIGSIDEEIRKLQTRRNSLVPISRLPNELLSTILMFCSQLKPDDDNDNDLRLFPPSRQRDRWPWTTVSHICSHWRNVALGCPVLWSCLDFSRPAWVPAMVERSRMVPLTLEVPFELVYHSQTEEAISTALQHMSRVKELSVSIPSGQAGRLKALIAGLQQPAPLLEVLYLDKFDFSPWDVNLPLEFLNGDAPRLRHLELRGFCLPLASGLLKNRLTSLVLFFSSPTDASWVQQLVRMLTSLCSLEVLGLKVPLSVKTISLTRVTHLPHLRSIELDAYITVCASLLDCISFPPTTTMQFSCAVSSPDQLIPQTSPISASLSRIRDLLLQSSSTTQFESMISSLIISTDTWDPKLALGNTSSKPWLELSFWFHDRPSPQSRSELFATILEAILPASNATVRLLTLEGLQRSWSSYQIWEKPASSLDSVRTLHVRGSCVRGILEWLTLTTPYPSQIDDSACADRFTFLPLLRSLHLSLVNFDLDNDNTYTTLEKLKGVLTMRSERQCKIEEVKLEKCFRLSNEHVESLREICADVRWDEVVDFLDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5D3</accession>
    <name>A0A8H5G5D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5D3"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034873075" description="Hydrophobin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5358664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="106" mass="10477" checksum="86D030E525E8F2B9" modified="2022-01-19" version="1">MQLTLLASIATLATLAAATIPASQCTTGPIQCCSSVQPASSDAVSKVLATIGVVLQDVNVDVGLTCSPISVIGVGGNSCSASPVCCEDKTFAPLAAINCVPVDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G672</accession>
    <name>A0A8H5G672_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G672"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="25090" checksum="F25E0E56E23C5015" modified="2022-01-19" version="1">MPIKRRSTFKAHLMTKHGLFVDPELCLVMIERPSRKPQDTTVKRKRTVKLESPIALPDISKLDLADAPYRFTDDNDNAEFLHDGTLYYNIPQPTTYPTPTPTGNNTYFIAPSPPSSTPDLSPSSSIRSTPAPPSPEFSESSWVHTPGTHHEYGQMKGFVDQTVLDHHQGQYHHHQQYHSYNYPMESATMVPHYFSGGQGYDVYAQNSYPWGFNYQSGGDVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Y7</accession>
    <name>A0A8H5G7Y7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Y7"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="483" mass="55110" checksum="5B25F3C990D4F6C7" modified="2022-01-19" version="1">MLEDRYCFDSDASLDAQTWSRFHSVYSNRVRMLRYLSPMFWTDQSDLSTILRNSVYSTILTINSPKLRELEWRTISELLPSSTLFMHDKIEKFSMAALHEGGDITNVEMSQLWSLVKTIPARMPFLTSLKVEPYLKESYVAPLVALLNSLPNLAHFATSTFHDISPFLLSSGASRLRSLEFSTFAYDDWAKEPTCKWGGPFPDGSYPAFVDNFAVCVMKYNAVSSFFQHHNLNHLKTVTIKTLHIEKPAVVRRLFQVLSRSCPALSIVHVDFHYEYLLIDEEEHIVVSSPTPTEEILAFDGIEPMLHCKNVTDFSFIHQYPTIMTDSDLETMAIAWKNLKWVALGYSPWVICTQANRPTLSRHCPEITEVSLLFDTKSSNPSTSSSPSTTPSLRAVPKLKALRVCTSELDLEDGGRLLCQVCDPQCKLEWTTHDANTGKPIELGPWKTIKETFPVFFELYRKAQEREDRINDLERLLELGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD37</accession>
    <name>A0A8H5GD37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD37"/>
    <dbReference type="OrthoDB" id="3267821at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="38207" checksum="E3413572B1EA6BA6" modified="2022-01-19" version="1">MSDLEEFMASPPASPEKNLSARSAGAPDSPFPSALTISEPLRMMADSTSTMTLNLQEYSFIPVSESQTPTAPQTPAQANSLKRGLPTDITEYAMSLSRNVRLKPANHEELALFAQAPPERQSVWTAAQLLVLSQRLDVLQPVDAPFVINASLSGKIEVLSAKTFLDSTASAYLTVPNTKVMDALKRLPELKEALGSKPSMQIISSKVSSRFTHHRNNTKDEISTSLGHFNSDTKTFIGPYTGIVALTRALVASIGKSNEIPVTIPLVVRVAFWRHVYVAEAVKTPNGKPGPDFWKAVDEGLKKIREAKDNDAARISAMFSKVLENDRTKYTDQGQPEDAEIQGLLSAAGTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDE4</accession>
    <name>A0A8H5GDE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDE4"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="80034" checksum="95E26F9AB919B352" modified="2022-01-19" version="1">MLVTVEECSPLIHYEPAGYWEEGREFGNESYSGGSYMLSWHPSSTASFAFNGTGFSIFGVQGPSLGNFVVSVDGVNNTGTANLPELKYQAVLFEARELDDGPHNVVFSIADGNRPVKIDFITWTSNMDLGNDDGNPPVDGDEEQVKFFQDSDEHFTYSPRDAWNTDPERVQGFKNQSGHSTTHPDASMMFTFNGTAISLCGSVGPAQTSSYSVSLDSMAPVWFNATRTWWAKDQVLYHASNLGHGEHTIVVTNAHQGTATPRSPPDLNSNPLVPRTWSRRQVKLKNIGEEGPILGLYGRGLRRQAVPSDAQGILGAFDLDYAKVWGADLAAVTSTSASPTLTPSSAGTTLSTGAIAGISVASVVFLSLLGALWFLNKRNNILWRHLQKGYMVQSQYDASGSPRSTSPGQNMSSVSLLHNQPIRRGTGDIDPFPPGYDAATRHPGANRPGLYVPYAGFGHQKSSSKSSSPLESSEESLPTKEGYQTYYDNAPTTLRPTEPIRSDTMLTSSTLVAEDGTFATLDDIAEGPKSPVKPVKRSLRRVGPPTNSTITTPTTPTPSMRISGPGNSTRSSRRRNKAYLSSQRSKASRRTHSSSPSRDQLLGPGNHFNSDSDLNEWEYEDDISDEWEEAQEFYASEASLAGILAGTPVSYGRRRLSLDARTQSELEVQTPIGRNFDYRDAPVPEVPLVRHGSSVAGMGTMDVTGGSEGRSYQPRHQGTDDTMSTLPAYTSKRNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDZ9</accession>
    <name>A0A8H5GDZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDZ9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="98" mass="10611" checksum="7D59CA6D25A1F9DA" modified="2022-01-19" version="1">MEFAGTDAGFAITTIVQHGSPNAVERDKEENKSTKSTNGMSLSQSISPSCSISSGGESGRKSDSGGICLRRDPRAVHPGDIINPYFKFTQFLELWLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GG95</accession>
    <name>A0A8H5GG95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GG95"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="33822" checksum="8412E9F53534B1F2" modified="2022-01-19" version="1">MILSGRPQCPKLRRMPYKDANRLCLKIPDRSGANPTTTVRNTVVQTGTTTGFVTASTTALTVSSDTNAISQTATTANLYTCPAPPNKRGSSLLGDVYPGCPNSLKKVALDIAKTACDCFLGPVQMSNVTSFMTQATTVSVPQTVTLLPSLCYRHCSRRIRDYLHHHRNLRVRHHHDNKHRHDYPDSPYNNEHYRVDSDDGHNCYHSDPTSQNYVPIHQCRYGTRYHDYTLTNDPGPNNDYAGAINTCLSSCYNERSQGCVTSFVFLQSSTLTCYNSVIPINDEGQYLYCDQSTDFSAAFSIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI31</accession>
    <name>A0A8H5GI31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="392"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1589" mass="175371" checksum="1CED2495CC6415B5" modified="2022-01-19" version="1">MSSPPPTAAPRRSQRDKRPAKPVTTVTDVPTTSRKRKHVDGTEDDAPGITGDEAQDADSEEGDEEDAGDDPEDEDDEDDADERPKKAKKAKGRPTKKPRKNDLEKDKDPSAATTTRKPRKPRAPKDPNAPAPAAKRAPKARNAVEARFDPEAVAKTTDISMDNPLFNALLNPNAALQSTTEDFLESLNQTAHQALAELLTMILRCCGCNETIDGDEAIDFDGASSKLDDIVEQLKQTTSPAGTYPLTLKAMPFHNPKIKYTFRSHLSEFFNRLITSSALLGSLYSSQLMETITTWLVPMSSSQIRSIRHTATVIALEIERALAEVGKDVEKEAEVTGRMREGEKKRARTKAADNGAAGTRGKDKELGAKMREIKDRQKRLEEFIAEFIDGVFIHRYRDLDPVIRTECITYLSTYFEILPSHFCSSSQYLRYVGWVLSDSSAAVRLAAIKALQIVYENAGAEGNTTGKRKKKGGVVLPALTHFTTRFLSRLLEIARFDVDVGVRVAVMSVLGCVDELGLLSEEDRNRLGTMIYAEEPRIRKGVARFVSGVWEEWIEAKMGEIEIETSSVVPSGRGGKGGRGRGRGRGRGGASTSKGRNQPAHEVDSDKVGIKGLVYLLVRWGRALDRDKKTGGEQDEDEDEDEEEQEEHQDDDAGTRNGTNADTEMTTESGVGGITAALVASPGKKSTDEASRGRTALAVEAIWDEVDIVRNWEAILDMLVLDHSALKENNANLSPRKRGAKGKKGAKSNGRAKKGKDKSHDEGVQEEDSENEDEEDKEEDHETQVDEAWRLNEVEEGILLEVLVASLSITKKEDETSIEAITRQLMKSLPRLFIKYQTDENRIANVLLLPTVMKLEAYLEMREQAAYTSLWSDIAKQFHAHSSPYVLTVAVQTITSHLLINTSLSNINSQQILELEDELATSLRDTVAGRGNTSTTENVEDRDIEISHLSEDETLTLTSIVLRLRILAGSRDLSSWMEESESGTQSSAWDIICAIAERGRLSLPGEGEMVGEALQLLTLHIMWKSRHLTAEATPTPEEIKQRESLISQRDALLEKLIDYAVGTPVHGNGVVESVKRVAFKKLLDLHILFSSLQIVAADGSLLPLASEALALNMDDEVQWRCAGYVQAEVERYAVAIDAEEFDDAQTDQENTDTEGEQTEEDNEEGDGDKPKKSKKRGKKAEAGTQAIASRTQLEQGYVLLDVISTLLRAIRAGAIHVRHGATLLAHYGRLGPSFDSCSKMMVDMLKEEGMVNDNAELVVLVITQAMKESFAIVQSSVRPEESSTVSLAKLLSGCYVIRGSQLVILHRLDTQHIVQVHTNLLTWIAKQIGSHHSSNKKKEMKTDITFFRALIPLFASLQSRDGLKIKAHLDQVLAQANVEPGNTKLWEPLRAYEKRLGTVMGKDKPPGTKGRPGRKKKNAGASAPSTDAEESEGEVEKLVDDGALSDATSSAPAPRPQRPKRAAASRKKPTVEDEDEDEPDHDDPSTPKAPRPRPRPRATYKTKTKSPEKQPTRVSENASPQNTQNTLPHGSPGLENGFVTPKKSLKRPREDDDERESEVVEDAPPVEPPQDLQMTPAADMQIRRKRIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ26</accession>
    <name>A0A8H5GJ26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_003339</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ26"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="73"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="351"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5365681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="441" mass="50742" checksum="0F9DE43769577136" modified="2022-01-19" version="1">MLDMRMVSCFQRCRCAYRYSHRLYSTVKPKYPPSIDICGTQYPTDEVTNITPAIISKIPIRLHTQPAHPLSNLRSLIESHWPDFAHLSSFSPLVTPFKNFDELSFPKDHPGRSVTDSYYINKDLMLRTHTSAHEVEVFREGQSKWLLTADVYRRDEIDASHYPVFHQVEGAKLYESNSTGMKQLEQDNLRLEQYLAKSNIVIEDVANVSETNPVQERHDAVQAEMVARNLKLELNSLILTLFGGAREGAEGEEPLRVRWIEAYFPFTSPSFEVEVFFRGKWLEILGCGVIRQATLDTAGVQNKIGWAFGLGLERIAMILYSIPDIRLFWSTDPRFLSQFKEGEISTFKSYSKYPSCFKDVSFWLPENSGFHENDFCDLVRDVAGDLVEDIDAFVHPKTKRGSLCYRINYCSMDRSLSNEETNEIHKTVVSRLTNEFGVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJG4</accession>
    <name>A0A8H5GJG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJG4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="24129" checksum="4771C81812017BA7" modified="2022-01-19" version="1">MFSSRRIIFVWKRGASPTISIFSLASRHRSNSAKLGFPGALLRVNAVRCCQGCFDLDAQQNSTTDDHRNQDDSPHASRTTPATLIPTRMSMSDSRKSQSQIVSVISAPGNRKTMDIDQRSPSDAFASVHLFLNSFSKNLNTNANLEGLACARTQPREFRVISSGRSSNFQRSSLRLIVHRCIDIQPDTISAVSRQFHFAPEFLAAWQQSGSHWYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL48</accession>
    <name>A0A8H5GL48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL48"/>
    <dbReference type="OrthoDB" id="3361196at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034644046" evidence="2">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="22821" checksum="A33E6810C6D5A879" modified="2022-01-19" version="1">MMYSSTLLAFICALCALVFTDVVMQAGASPAPLLPTKTSLNRGFEELGFASEASLLRRTDPTFPPDPPSCPICQQNYDRINNCAQAAPVLANFSEIIFNPGAFINVIQCACTETFQSVFPQCVDCFVQTNQTQVLNAPDLNSVVSGMRQVCALASTLLGGVASTDGELPSTTASPTPTPTSTNAASALYPRLSSTVSGAVFQVMILSAAGVVGGVLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLK4</accession>
    <name>A0A8H5GLK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLK4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="760" mass="83050" checksum="45AD74E2741C6F76" modified="2022-01-19" version="1">MSEVKPPTRRPRKDGAPLPSDNSQSSEPITAQTTEPAGPPPLQAGNGMQLRGKRDAHPATPDLSTPKRSSEEVQADKKAKADAKEAKKKARQAAIAKAAEIEDRQRKEDQEAKETGHHPPQTTKEKKARKKASSKAKSAQDQTPEDVMNTLDRIDKVLNDVAKLTVSTAPENLAAVPATAKTASKRKRAEKRPTSSLTVSTPTEADIPSPGDETITFLAADDEEIQTAEGLNDSGDEGKPPKKARVKKGELRAEVKAKRSAPSESGSDDQNDTVTQAPSKKRKKVLEGFRKENTSNAPPVSSTDNLDSPTQVNQQPAVNTEEEGAKYEPGGFADDEGDEDERDATVKSRSRPVKIKAVAAVAEIKSTVKIVPTTSVPELVTPTKRRKDVRLGQLASDLQIAFSKTFMPVVLEYTGCLTAWDAPKPQDLAELWGSVMPKPFHEQFAKLNADKTIETLVEQKLTAWRNLLGRTALVALKEVFQVQGLTTADERKEYVRHQLEGDYRCRNFYYLNVLKTGDKTRYGGPFQSFLIAKTLAEHLKCFKSISEENRVKERPVGALVLTIIAVQRALTFYETGDEIMPRGGDGHFSQSVWGDRQVMIDGKQVELKTTTQFHEIFQKNPVTQKDRITSTQWDNIIKAAQACIVNKMASNTPKTIPPPAENPSTANNDWVMPDDDPEIFKTPAKATSQPDPKDGDGVRDVGALGHREDSESASSEDGEEDENSEDDSSSGGDENSDTSVDESAAEDDDATGQEEQNIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLU7</accession>
    <name>A0A8H5GLU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLU7"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36412" checksum="28F08972107D9A9D" modified="2022-01-19" version="1">MVDWNSTAEVLHDSDVFTKFMHCIFGLYIWEWATSLYFDVSVLIGIRKYKWPMTFYFLNRYCLLAALVGIIVSMNVTTEIDCQTLYMFNQIMGNFAIGLSSINLSIRTIAVWKSHYYVIIPLVAVILGHWVLLLRTVVLVKASWVDGAGCQVTGNDPKLITAVYIYSMLFDFLVMILTGIKLGFGTGQKSQLVKMLYLDGLMYFLIAFTANLVAVVFSVLNLNPIMSIIADVPASTIATIAACRVVRRLNTFVNSQGVDLYTPHSGARPAQISSGGFTTGTVQFSNARPQETRIQMSVMSKTEYETHRDYDDVERASPGETKGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM18</accession>
    <name>A0A8H5GM18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM18"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32585" checksum="7D29633D5417C3D0" modified="2022-01-19" version="1">MARNEEKAQSMLYRFREAQAAELGLGTRADRRPRMASACKSLRDCERWRGEILREISRKVSKIQDAGLTDYEVRDLNDEINKLMREKRHWENQIVALGGANYRRNVSMLDDDGKEVPGTKGYKYFGRAKDLPGVRELFQSRKNEEEEENKTLTYYKKFLNQGPAYYGDLDENDGKLLEVEKQAEDEEWEEAFTTIKEALGLPEDTSTPPISRSKPSPSDPSPPSNATDNPAFAQAQAAASYISFLDTENLLPPKMPSRTEMEGVLLELKKKALVEEYFGNDQPMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMB5</accession>
    <name>A0A8H5GMB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMB5"/>
    <dbReference type="OrthoDB" id="3069822at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="11125" checksum="549C531BBA6E55CD" modified="2022-01-19" version="1">MLWDKIDKKYSSPGPTSWFLDFKEFMSWTLDEKKDPANQIASLGAVLTRLKAYGFTVDDKFRALFLMDRIPQSWGNYAQFTLATIEPKNLTMAHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMU1</accession>
    <name>A0A8H5GMU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMU1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034242119" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="630" mass="69576" checksum="A8BE7A84A9850EDA" modified="2022-01-19" version="1">MRQRSCTHPYLSMKLQLLSLFLLVLLISSAFRQYTKRICKCQPGQWCWPTGWEWVAFQRRLSTPNTLIKNQRPMGAVCYPKDPLYDPASCQYLNSSLHGFDFVFMSSQINATNWYNYDSIITPGKEIGCPYFPLTPDSVCEQGRVPPYAVNASSPQDIVEAVKFASYHNLRLVVKNTGHDAIGRAFGVGALEIFTYNMKDLIVHNNFIPKGAPRRTPAVPAMTVGAGVDWNQAYAAADAAGRTIAGGLSPMGTVGTVGWSLGTGHSLLSSSFGLGVDNSLEFTVVLPNASVVTVNEYLTPDLYWAIRGGGGPTFGVVLNITIKLHETKKYTGAFFEGHCDSDECFLDLLTTWMKYHNAVSDAGWSGIWPAYNRTLYLTFGTPSDGAPSGQTISILNAFMEEAKTLSGVSIFVSTFRDYVSFEDFCEKNLKEDHDAVGFNFTEVVFDQVQLVTSSWLLPREVTAPENAEKVARAVTSVDSAVVIPFLVGGGVVNEFPKQSTSAANPAWRRTLVDMTIAETGRAYDDINVLQKAVHDDIAPFRAMAPPPYGGMYLNEADILEEEWQAAQWGDQYARLLKIKRRIDPKDLLIVRMGVNSEGWDEEIICKTIAINLVAHAFTSLIASVWCLRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQS5</accession>
    <name>A0A8H5GQS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQS5"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="32673" checksum="7B113F14A198B7E2" modified="2022-01-19" version="1">MDADARIEAACSFILQSPPGEINDVLNDVRNIISDDETLEEGVLPALKEYNLTQFITVDIPGTEHQSIISEAARLPASEDGEERWIDPRSKQSFVFNHLTLEATDPQPFEPDGDAEEFRSSLEKASLNYLLAHFHDGVTSIFVKPGVTNHFIVQIVANKYNPSNYWSGRWRSEYVVDLNEHTVQGKILVNIHYYEQGNVQLSTTHDISIKLPPPVVTASPSAAASKILALIETEEGNYQTSLNDTYHEMSEKTFKSLRRALPMTRQKLDWDKVLGYKLGAELSSSKGTFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRF9</accession>
    <name>A0A8H5GRF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRF9"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="47145" checksum="D045C2DACE3988F6" modified="2022-01-19" version="1">MYSLYKQATVGNVTSPRPGIWDMLGRAKWDAWAKHKDLDPYEAKWLYVEALLKVLRKYSDKTIAKNLVQELESYNGDPSHIVMSRSSLSRTPSSSGSSSSEEDVPASNFAQLNILHSPQQRVRPQSASYASSPHLSPQAHRSQSSLSSQHRYRTPLTGSMPMTPPLPQQGMLQSPQTMLSPQGIPVMQPHPGYEAPSAYVDHSPTVPNASLYPAGSSYINFSESQGQLASPAIGSPATLFPGRPFSQNQPPMGQYGVVRPASTIQLQRAMESIQSQVAAVTERLEMLESITSAQLSNRSPAASYNPVAWRAGQGGSPNDERPEWDIDDMGMWSFILHPTLRAIKRLKKSSMFFAKDENRSPGMIVIRRLCLDLSFWIFTIVFTRFMWRRSRERRREVNTALALLWRALLGRRERTLVDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRX3</accession>
    <name>A0A8H5GRX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_001238</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRX3"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="13"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="528"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5369899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="749" mass="81500" checksum="AFA41B02C6396288" modified="2022-01-19" version="1">MPAPTTGPRTLYDKIWDDHIVEQKEDGLALIYIDRHLVHEVTSPQAFEGLRNAGRPVRRPDCTLATVDHNVPTVSRKNFKTVESFIEEPDSRAQCAALEENVKEFGLTYFGIVHIIGPEQGFTLPGTTCVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTLLQKKGKNMRISVDDDLHEGVTSKDVMLHIIGVIGTAGGTGCVIEFAGSVIRGFTMEGRMSMCNMSIEAGARAGMVAPDEVTFNYIRGRPLAPKGEVWDRAEAYWRTLKSDPDAKFDIEVNISASDIIPTVTWGTSPQDVVPITGVVPDPANLTDPVKRASAQRSLTYMGLTPNTPMEEIAVDKVFIGSCTNSRIEDLRSAARIVLAAGPDVQVPSSVHAMVVPGSGLVKKQAEIEGLDAIFKRAGFDWREAGCSMCLGMNPDQLSPGQRCASTSNRNFEGRQGSGGRTHLLSPAMAAAAAMTGKLTDVRRFLGAAADAHIAAGPKLKLISTLEVMDDDVLPSPKPENVGVSSRSLPPSETPSSVEKFTIVKGIAAPLHIENIDTDMIIPKQFLKTLKRTGLANALFYTLRKDPHTGEDTDFVLNRQPFNRANILVCTGKNFGCGSSREHAPWSLNDFGIRCVIAPSFADIFRNNAMQNGMLPVALPQEQCLALAEDAEAGLELEVDLEKNEIRRPNGKESFTFEVDPFRRHCLLNGLDDIALTMQDVKSIDSFEERRSEVWPWLDGFGYEGKIPLSKPSGEKKTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRX9</accession>
    <name>A0A8H5GRX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRX9"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29185" checksum="0BA8DF2736B4CBE6" modified="2022-01-19" version="1">MDLSHHLSAIAQARVVTPLKGLDMYTRKPGIISLAGGTKSQCPLLKYTLLLGLPSPAYFPFASVSGEVLTYDSFSLKTSPESSSSWFWKWFSGSRSKERTTTVTIGKYPKQPEDINLASSLQYGLATGLPQLEDILNEFVRKVYQPAYGNWTTLVHTGNTDGWGKVVLTLFNPGEGLLCSEWTYPSAMASAIPFSVTPVPVKMDSQTRGMPRPRVLYTIPTGQNPTGATTLEERKEIYEICVEYDIIIVEDDPYYFLSYNVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT52</accession>
    <name>A0A8H5GT52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT52"/>
    <dbReference type="OrthoDB" id="2943593at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="38648" checksum="57E8B6D40A3EA6DB" modified="2022-01-19" version="1">MLKPFPGPPSQPIPQLPTSSSSRSMIVHESSSSVYSADLRKRRRGADFGFRRPSLSRPISDSPSDNSSFSATPPGTFTGSDSDSSSIHELPFDFPLPPPLRRMQSSPLDEARKGRGPSTYRARGSSIAQPQVYHSHAIADSLSDLDADVSASSRPDLAYSVELDTSSLELDLENEGETLIMSTSGWPTHSAAPSHPIASSSYHDRVHSLSLNRPPIHAPHAPSHRPIPKMRSLKFAPDSSGSLDRLGVTMEHPGQQRSLLRGRALSMDFRSHQSPSRRMDAGRVRSSNLQNPAGLATPILRRTPHSAPAGRPHIDDLSGSGLTSFIDISPDPEVRRSSVKKLLSKASQVFRPSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTF6</accession>
    <name>A0A8H5GTF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTF6"/>
    <dbReference type="OrthoDB" id="3244423at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="57553" checksum="C142C64E45588B9A" modified="2022-01-19" version="1">MQAYPRDPPHHPPKRVSELPDSLLSSIFLRCSPSDAVERTLSRVCQRWRNVALDLPALWTRIVLDCPAAHQEDVLQTYLQRAIGTTRNSPPLPLELYIEGRDSTPWTRLIRIIHAHKPLWRAISIRVLSGVLSFTDAAAQFTHLDLPLIEHLSIIFHIYPQDDEKEILMESPVIIFAGSTHVKTLRLQGTGAAYLQLAKQNVTTLHLKESAFRVRECPDLHILLQFFPSLVHLSLLGDFVRIGLPQPRRIIDTPNLRSLRVSDSTTLSTLLLSLSAPGLEFLTLRNFTCAQLQLFRERYEPWSDSPNADRFPKLRTLVLIRPEVSKDELRRLFSDFASITRLDLINCFSDDALEVLAEKNPDLGRVGLSTLLPLPYLEILSVHHLRNVEQALGQFVSPRAEAGGSIPKLRLHANIPRSEVFSLLHENIIWRWDKLDSWPLSDVSASEYRVFEDEHDLGMQMLTKPPNERNLMLNLRAPQREDESPNWWQKLGKWLKRFIGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTI2</accession>
    <name>A0A8H5GTI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_001804</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTI2"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5370682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="489" mass="52788" checksum="7337071E7D957A69" modified="2022-01-19" version="1">MPFPTVVSSPGKVLIAGGYLVLDPAYSGLVVSTSSRFYTVIQPAAISGNIRVRSPQFNAATWDYSVSFDPTLVQDSPQNASKNKFVQLALQDTIFLAVEVKGVQAVKDALGQGLDIAIVGDNDFYSQRAQLTSLGLPRTLKSLASIQPFCPQGVTLSNVHKTGLGSSAALITSLVSALLLHFGVIPPAALSDEQNEGRNLAHNLAQFIHCLAQGKVGSGFDVSAAVFGSHIYTRFDPSVLQDLMKDTHPTSIFPVVSHTNKAWNYQIGAFQLPPMTRIMLADVDAGSDTPSLVGKVLAWRKEKKEEAEELWKTIDHLNQSLASTLLLLSSLHAKDPESYGKAVRWISSLQAVQWTADPSVVEDIPAVSVFYEAHKITQSIRANMRKMGVEAGVPIEPEEQTRLLDACVSQAGVIGGGVPGAGGYDAVWLLVCEPSETQHDPLPREKIEYVWSNYKELSVSPLLAVESMAKGARMENIDEIKGLRDAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU61</accession>
    <name>A0A8H5GU61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU61"/>
    <dbReference type="OrthoDB" id="3353710at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="765"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1178" mass="133886" checksum="1CCC1A0E528D0B26" modified="2022-01-19" version="1">MLESDLRTQSTLLCPKCHASLVTGKIPPSSSAKILLRSKHALSETEIVQTKCLIDNAQLDLERFDEEIASLSGILEDLKKKRAILSEYKDEHSSLFAPVRKLPIEIFNEIFTIVCLSEGARSLSITTADDNQSKVFPQSLFLAQTCSLWRSILLQNHRLWSHLRVDLSCGESSHDYRPLLQSYIDRSKPASLTVELVAFRFWHSGLAHRRELESRQSWNLFQLLLDTNHRWANASFDLSKRIYLRMEHELDWKRAGIVTDKAFAGLKSLELKWNYGLDIGLVVEHCMFFETFRHAKSLQSLFMTCHDASFQTLPELTTFGVETGNPFGIARLFDRFQGLKFFTIKRLPWLHLGPIQELIGQLQLHHSTIETLWIGLSPRLREVNEFGAPHVLGLFDLPSLKTLSIHGTELKRLFIEDDQRKWMLECLKLTLSRSPSLHTLTLEGHLLPDHALVNVLSTVPSLRRLTLITHSDYAKVVSSKFFRALRLPSSEPGGFDFFSPTCPANVLPHLTYLEIRLEEQAVYTKTTSRLTFFEPKLPDREIILSMLESRRGVLEQFELYALVRSIRAREWVAGLQPGGSYWQRLLDLKSVGLECNVDVVKGTSPVHVVGLMIQGDERDSETTSESSFLITFENTTYMYVAIAVSLFSSVPPSTRTRQVIKKLKELLKRVEQNDSQSAHSATNGRNPTFLSAKDFAILRSGTTFSITDPEAEETRDLVYKAQHGIDVLDEKLSSLTKTVAILQRQRSILAQFRSEHLACISSRRNLPVEILIQIFSLCCLSQDSHSLSITTEDFASKITPQTLHLAQTCSHWREIVLDSPSLWSDLRVDVGWRKQDVYPLVQMYLRRSKPALLTLTVEAVRSDQNTPSWMPTGYLLQLGKPSWRLLKLLLKTRRRWVQASLDLSMDLFEGINDEINLEGYHELTMKNLKSLELRWDLSKTSPSDDSWCPFFSAFEMAPSLQSLRTSLYSIHSGPFSQQLTTIEVETVVPEGLEDMLVQHPALKTLKIQRLPWYCLSCNADAFQDVEALKHDSLETLLIGLSSTRPGKRQHGGPHILDLFNFPSLTHLSIHGAEDVQLLIHGHRGREVMVACLKTMLSRSPDLHSLVLDGDLVCECRLVELLQAIPRVRHLTLIDPLYDHYESMITDNLFRALQLSPNNASGRQLNSFSSSSLVPISSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUJ2</accession>
    <name>A0A8H5GUJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUJ2"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="239"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76960" checksum="F4B6CF9020500051" modified="2022-01-19" version="1">MLSVLSANPLCFATTCTVISSIVSLTVIHRQESTYLIHTSNPVTSISSDAFYYGTDQAWTDIELITSVHLSNQRSIVSEHSLKTQITRFRDLSDDVWTDEFLDGIAVAGSGNFMLDASAVRWMRDEGIKTLFLSGTLEPANLEGMDLRNITLVRLSTTLPPGPFAVSTDATSGAYAILNVYLLRPDIYEAFMSGIIPNGDGSWQQTNLTFPERALTVNPDSPTPAQYIPIPSRLNSLDADGALAGMRFVVKDIFDMQGVVTTAGSTVYAETNPFVKSTAPSIQALIDQGAVPIGKTRTSQFAHGANPWEFRDYAYSWNPRGDGYLTAMSSSSGSGCATAGYDWVDFAVGSDTRGSVRRPASVVGVYGIRPSFGSLSREGVVPLSEEMDTFGIFARDPELFYDVAMSWYAQSPVKANSSFTSFPHQLLYPYDHFPVGNPAAQSIYDNFVNTLHEQLNITRVPINITDKLLPYLPDGSFDQFKRHADILAEYHSWNTVGRPLVETYQLFGRDPVFDPVPESMFSRAKTLTLEDYQAAVSMKNKFTEAISRDFFGTDLDSKSCSDSLLIYNTGMEGLPSYREQSYNSFPGAPPDTQTVFKSSTTGIRATDNLHYIASMGGLVEVTLPLGQVDYYSWGVSQEWEVLPVSVQLVAKRGCDEMLLELVNELGREGVVKEVISGEAAFEQVLPSENPVGPSWFLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV25</accession>
    <name>A0A8H5GV25_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_003463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV25"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5371749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63493" checksum="34FD04DEFC209625" modified="2022-01-19" version="1">MARDQAAVVAVAVATCASDTLKFVVATTYGSVHKRHRKALNPAFSSSQLKQFLGLFERKTRKLIQKWDEELLNVGNDENEGGKGQGKIIDVTKWFPRVTLDIIGESAFNYKFGAIDGSDSGTNELLEALKNIFIDSRARTPADILFHEWRLGLPSWVTRVLGLRTPEDRRFSTYLETSKRCARQVLERANNEGVERAEGNDLEEGGKGKHKKCAGGDKMNGLGSRSPLHVTKMNGKENGKAKANGKDVLIQSNNAEDPKKRLDDDEVLSQISTMILVGHETTAMTLSWLLYEIARHPEDQRRMRQEITSVKERVRVRVREGQVGNGGEVRGPGRTREGANGRVPNHEEKNLCDETITSMTSNDYDSMHYFNDCIKETLRLYPVAPIIIREASEDDVIPLLHPVLSSANPSSSDSEGTLITQIPVEKGQKVHIPITVYNSLPSVFGKDAHEWNPSRFENLRNLKSLNPNSSNSNQKLQGPGHANGTGEDVNLGFLSNLLTFSSGVRGCIGVMELQTILFGLIESYEFSLPPEGLDIQQVPAGTTSPMVRGQLEKGIQMPLVVRRIRKEEVGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXM4</accession>
    <name>A0A8H5GXM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXM4"/>
    <dbReference type="OrthoDB" id="2930976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="769" mass="84380" checksum="9BA8009E8D68EAD5" modified="2022-01-19" version="1">MSRPDRVSSTSNPNPPRGFDICAEFRRLGLRNSYARVPPSFLTEQRVPECFQALHSDRLPDPQTFTPSKDSACYLSLSDNEIDNINAAFDAFLIFQPLTDKVEGGPKALQALMLDTWKNGAWKWLLFLYNGGLDLNDTVSRASSNVGGSSSSSSSLKPFNFVKATITLSLFSILKGITLSTVLCKQLIKCPELLGVIGYLWADDPERLEGIPLPPHIVHEELTVAIQNIALDDPNNNPSTSNQQNRQNRKDAARAGTNASGSKSSDSTKARTSTQPPSAQTTIFLNASSHTSPKQVIRVVTKNLERLLGTEERCLDTEALYKQAYLIEALGKASPELCQAMHSDFGKGGLLAVVGKTVGALASAKSMSGMSGGMSMRDMARSMSSRLTVDERSGTPAHNAAEVLIGLVLIEFLLEGEDMSAVVDAVKAGLVKSLWMAWKVFGRYNGCRIAVDHVIYEILGPSLIFRSVLHAVEEDINKSGLVKDFEAMPETERNEVWFDFYEHYEILLIYRDEIDDAMAAARCANPACKTRQLEPPQPLKLKRCSQCEYTKYCSDQYIRQVKDRDFARSAAEWVAKERVDYIVEHTPAVLHHDLDIFVIVDFTTMKKYLKIGGVSKPPAAADVADETDPNDGNQRLKDKVTCHVAISAKVQYGKKEVHTLGAVCLWEEFKAEAYEEQRGTWVKVGENGVPLPKSMARAKTASAALVVGDNGAGSEEAKKKKKKKNKKKKKGATSTTAEANASTVLEAESEEEAEEQGKVGNASLSPEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYZ3</accession>
    <name>A0A8H5GYZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYZ3"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37503" checksum="128D61E7D087BBAF" modified="2022-01-19" version="1">MDGKRTSSPVVDSTAFNDFLRRNKAVVCALSASYISTFAGYPLDSLKSRLQTTKTPISVPRLAAIVYREEGVVGFFRGLWIPLMTISFVRAASFTIYTSTKEAFRDRQWLTRNSIIDVSCIGGISGAMSGALISFGSAPFELVKVRRQLEYSIAASKGIHLSKAPGTFEAVRDIFKNNGIKGLYTGFRLHFTRDTLGTALYFLEYDGMRHLMGRQRSGEQGPTPPWLPIPASLVPFFCGSLSGVTSWALIYPLDVVKTKVQQRALAGDRYRGVLETLTRLIRGTDPANPKPLVHGISRIYRGLGVSALRSITTHGLLWTFFDFVANYIDNLPNPSSENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZY7</accession>
    <name>A0A8H5GZY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZY7"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67975" checksum="DC88A8AAC29D8435" modified="2022-01-19" version="1">MPPADNTPGLVNDAQVNVELTISASQVVVIGAGFSGITAGIRLLQRVRNLDLTIYEANAGVGGTLWTNRYPGLACDIPAHSYQLTFAENPNWSAFYPPGPEIREYLGSVVDKYKLMPYIKLQHKLIRSEYDEQTGKWQLTIQRAILEPTGQSNTEDFFDTADVLITAIGILSRWQWPDIQGLETFQGKVVHSAQWETGEGDNSPTAKWEDTVKGWKDRKVAVVGVGSSAIQIVPSLQPKVAHLSNFVRGKTWISSVFGQSLIAEISKNEGASNYEYTDEDKKRFLDAKVYNEYRKKIERDVNAALHQATLLGNPMQEGARKLFRAEMIRRLAKRPWIADHLLPDFAVACRRLTPGPGYLEALCEDNVEFVPDAIKQVTLSGIETVDGRHRDFDIIICATGFDISWKLPFPFIGRGGITINEKHHPHPRTYLSVAVDGFPNWFCLLGPNSVGAGSLLIVMERQVDYAVQVVLKLQRERMKSIEVKKEAIDDFDEYLESYFPKTVFGSKCKSWYKMGKEEGRVVAVWPGSPLHAVYALAHPRWEDYNYEPLDPGVKNRFYWLGDGSTMADTIPGVDSSWYLDPKAVDVPPGYGPCPSLIISHRLALNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0E3</accession>
    <name>A0A8H5H0E3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0E3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034905237" evidence="1">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="70" mass="7092" checksum="FBC2213CED920CD2" modified="2022-01-19" version="1">MQFSKSVIRAPILAAIAVILIVQSISSDSQVSAAPAPPATYEPLLHATAPAVPLAAARGLNSVSKTHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHP1</accession>
    <name>A0A8H5LHP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHP1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="63" mass="6858" checksum="B6C59FF67CE25A18" modified="2022-01-19" version="1">MALFTSQSTTPQALRSTNHHGIPKVPQPRPSWTTSNRNITELNEETGDEVVECHSAISAVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK12</accession>
    <name>A0A8H5LK12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5359979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LK12"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5359979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="42723" checksum="8497D566F165ED58" modified="2022-01-19" version="1">MLASLSSSFRLLSRRTPRCRYFSNSFTTKIEAVTPETRRKRVILSGIQPTGVPHLGNYLGALVNWVDLQRNAAPEDELLFSIVGWHAMTLPQRPKDLMESRMDMLAILLAIGIDPKRSIVYHQNDVLTHAELAWILNCITPMGKLKRMTTWKSRLAASKNLTDDSDIDETSLNVGLFTYPVLMSADILVYRATHVPVGDDQTQHLELCRDLADQFNRTYKAKHRLFPLPIPLNTPSKRILSLRDPTSKMSKSSPDAASRILFTDSPSEIASKIRVAVTDSIPGITYDPINRPGTANLLTILSAYTGEDVHAAAKRFEGKNHGALKTEVTEVVQEMLRGPREEYGRLKGDKGYLVEVAKEGAEKAREKSEATMKEVRERIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMI1</accession>
    <name>A0A8H5LMI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMI1"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="188"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5363050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="40129" checksum="3E724A04B32E3E41" modified="2022-01-19" version="1">MTSSSASPSSSSTSPPPPPHAMSLVPIESAAEWRPIFHDSLNNQVVLYNPSSHALSIRPAVHHQRPPHVQPHPQPLPPPHTRCPYCRRPLPTGFRDYEDDYDYNEYDGRTRTSNYFNILAIANRTASEPSSSVPSSRSPSPQPYRSSPPSPSLQNHTPRDENGESTYYSDPTAFPPNSMAEGYFDAFFRVEKKLGMGANGSVFLCQHVLDNNPLGRFAVKKIAVGQSHTYLLQTLREVKLLERLHHPNIVAYHHSWLEHTQFSPSGPRITTLHVSMQWAEGGSLDDFIERRIRGFLKEKGLNGNGNGGLNRGRGRGRGRPSGETVTETKAESEGQGQGDGDGEAEAEGELERQRENMHLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPV1</accession>
    <name>A0A8H5LPV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPV1"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="513" mass="57733" checksum="0F2E2BF755750068" modified="2022-01-19" version="1">MMASPSIHVDPARHISKVDPRIYSGFTEHMGRCIYGGIYDPDNQHGLSDPKTGFRKDVLAALKELNVPIFRYPGGNFVSSYRWQDGIGPKDARPRRPELAWLTEESNQFGTDEFMEFCRVMGAEPYICLNMGTGTLEDALAWLEYCNSSANTYYANLRRANGHSEPYNVKYWSLGNEVWGPWQVGQMESQDYAKKAYQWAKAMRLLDPSIKVVSCGETGYADWDRVTLKKLAPVIDYHSIHIYTVSEGDHSVNVMGPAAAEKAMDITKSLIDLAKIEAGLDKEITVCFDEWNVWDPVRAPGEKGAEEHYDLSDAIAVASWLNVFVRKADVVKIACIAQSVNVISPLITTPAGIIKQTTFYPLKLFANLMQGTSLDIHVVSPSYEGTKTVPDFISKLEKQDQGRYTKWIDVSGILTESQDTVRLAVVNRHPSESFEVPIAFGPACTVLEDAVVKVYEVWSENLKDSNYYDWEKGVKGEEKVLIVEKDVKPGDWNGSYMFKAHSFQVLEFEIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQV1</accession>
    <name>A0A8H5LQV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQV1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="21782" checksum="5C554B2E78950621" modified="2022-01-19" version="1">MSTQGSPKVDEACLKTAKTRLCEVFDIPSLRTHQEAAALNIIRGQSTIYDVPTGGGKTLAFYLSLFYHWDPQHPPSAYQKSMIVVSPLNALMDAQKKALEERGIPATALNSGGGKAEDIFGVRLRNALCVNKLTYLLETRGWDQVHQVSRRFRLARTCALKVISRNSSAEPALQEELYTGRYVGFARSSSSSSMPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR79</accession>
    <name>A0A8H5LR79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR79"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="466"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63120" checksum="9D3DA9A141B47921" modified="2022-01-19" version="1">MFHSLASPLYSVPDNLTIPQFLFDKNPLGFLRGAQSVDVSTTQPCMIDEISGRQITFSQAKSRSDALARALKSKYNLSENAIVSVFSPNHMDYPICIWATHRLGAIVSPMSASLTESELEYHLGLVKCTIMFVHHDCLPVASKAIRAAGQDGIRLVIIGNSDSGLVTVDQLAREGSSFPTYPERSMRAGEAREKVAFLSFSSGTTGMPKAVMISHFNVICNILQIATFHRTYDPSVPKELRRFKPGEVCTGVLPLYHIYGLVLNLHFVLFARMTLVVTERFDFERMLKGIEKYRISYLWIVPPQAILFCKHPAVQKANLSSVKYCLIAGAPATGDLFRQLLQVFPEIHLGQGYGLTESSPVISMFPLTQKVGTLGSAGQLVSGTTIKIVTSNGTLAKFDQEGELYVKGGQITLGYYQNAKATEETFIDGWLRTGDIAIMKPNGDIFIIDRLKELIKVKGLQVAPAELEGHLLDHPYIADVAVIGVPDEYSGELPRAYVVLHDEQAKEAKVSRQAEEEIRVHIFKHVADAKAKYKWLQGGIIFLDVIPKSPSGKILRRVLRGNAKGSGNVGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRS7</accession>
    <name>A0A8H5LRS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRS7"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24410" checksum="5C142C2973DD230E" modified="2022-01-19" version="1">MASTTSWSFLDPPNRGYHRSFVTKISSNQWDKYTDCSLHIHYKLSVLAFWDPYELANYRDSYTFYHHGHSNLELPVVAMNSNGSSLLLNVALSGADLEIHVPFHLRYGEPSPDGHQSAEISMPIAFFSCPAAQVSGVDSLPWPTEFTTLSVSDERACLAIQSEPAAAVMISVPVGNPGDFHIVEAGTVLTMVACFCYLVVVFRQTWRRLYYNSGHAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRV5</accession>
    <name>A0A8H5LRV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRV5"/>
    <dbReference type="OrthoDB" id="3251728at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="192"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39025" checksum="AFCDB535347CF66B" modified="2022-01-19" version="1">MSQPYVYSPPPAYLASGYVNPHVSPQASPFIPSASLYGSPYSGNSPLPPPSPQLGPAIPFPAVPFPGTPNFDYQPVYTDGDVFRPRLPSWHGPPPSSPFFPPPSSALLTPDPNPYFPHHSRRRSFGGTTPTSPYLGLGVPEDDPWGPQIYGSPLTPSQFELHPWLNAQTFSGQLLLDLSAHDFNPLQVVSPPPMTQTVPVPYEYILMPATRPPINRLRIVCDLIPQWPMDVVYNPQNVNPASPGVIPIGSGGLGSPYGSPSVLGHQPHPPITVADILYTIHKSLHTRISQLDWAKLTLAEETAVAKVFTKRCKAVGSLEAVERERAEGVKRIDFLLGKVWFKGLVMDWNDGVMKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS87</accession>
    <name>A0A8H5LS87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS87"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="248" mass="26555" checksum="A1B7E6032BBAA758" modified="2022-01-19" version="1">MPHNFMIYNGQTLSSTSDFQTSKMTRSPLVWKNLASQFVSNKNVIFDLMNEPHDIPATTVFQMMQAGVNGVRSSGATSQLILVEGTSWTGAWTWTSSGNAAAFAGLKDPNNNVAVQMHQYLDSDGSGTSPTCVSSTIGYERLADATNWLKSTGLKGFLGEMGAGSNPTCITAVSGAICAMQQAAGVFNSSSELFLILPNPPPSYNPERFSGNLNRAAGPWWADYFQSIEPPNGAAISQILPQALKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSQ2</accession>
    <name>A0A8H5LSQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004455</name>
        <name evidence="3" type="ORF">D9758_016399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000222">
        <property type="protein sequence ID" value="KAF5336772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSQ2"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5336772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="269" mass="29830" checksum="86C9559C15FE0E89" modified="2022-01-19" version="1">MNYIWARFVKAYGLQFSSYDVALDVTDADPLSTFLSPKSTYPFVVGHRTGRLEYTTESNHSWPNTLHHLPGPATRPASKSHEVLEERLRAASGKEVEKTTLEGDPSTTASQSDVGTSKSALEPAFFTSEEHAAFGASCDPEIYQSPSLGRFRRHNQPQSKSPFTLILTTQDVKSYKPAHHGFNVTLDLIQKHPDLLNDPEGKEVKAKDKVLWVAQSVFHDIIPAKELGLETVWITDREGTSMGGPKELESSATWVFNTLGKMAEAVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTJ1</accession>
    <name>A0A8H5LTJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTJ1"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="116"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5369500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="35728" checksum="5A6F6C529928DA0D" modified="2022-01-19" version="1">MSFLSRTQAQFLYDSSRKWFTLVSALICPATFVINAPFGRFAQKGESFLSFDGRKSWVVMEIVSPITFLYSFISSPLSPGASISLSQKILACAYLIHYANRSLISPLRTPSRSKSHIIVPFLGILFNTFNGSLMGSYLSSPAAREYTNSIGPLFYVGIFLWAFGLVGNIVHDEILLNLRRKAKTKGKDTANDGSGNQTSKTSGEHYSIPYGLLYEYISYPNYFCEWIEWAGFAIAASPIPRLSFQSILTVLTSKDAFFAFLYARPGAFAPTLTPPWIFLLNEMVLMVPRAYKGHQWYHERFGESYPKERKIVIPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUG1</accession>
    <name>A0A8H5LUG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUG1"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="305" mass="33971" checksum="07FB41E2934AC996" modified="2022-01-19" version="1">MADHEELLRILSAHGQQFLSSFPESSIAGKKRKRDQQEPDLVSPKDKEDHSEDEESEWGGINADSDHGSEVDDSDFDENDDEFVAGSSMLNNGGSVSSPNVVVFSDPSRKDTHHDKAQMKAFMSSKISKISQNSQPQKTQKSSVEDYEEERTNLQNDALLHKLVHTKLLSGSLNPELDLTPAQRRKALSGRILELAGDAKLGRGEKSVREAERNKASKRVREGLLAKEKERQKTKLEEAKNLGTYHPSLKKLFDQDSDAKAKKRQRGLQMGVGKFRGGTLQLSRQEVQSIQGPAGKAKSNKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWG3</accession>
    <name>A0A8H5LWG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_005038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWG3"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034995694" evidence="12">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5372097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="272" mass="30192" checksum="68132AB922C87603" modified="2022-01-19" version="1">MKAHYYPLVCILLPLINAHVVAWHRGMYCLNGTTPGQDDQNNNLPVNPLYQLKKEDWWMHHVNKCDEFPPAPNDLLELPANGEFTVEIAVNRAFTTLSYDGRFAGTYTGPLKNGSMAADGQLGVTESGEQPQCITDPNIHTENKTMAAGSAFAISYQSDIKDVTPENLVVFSVAYHTPWRRLTTYQVPNLPICPPDGCICAWGWVPNGCGEPNMYMFPYRCVVTGIPGPAPLSIAQPATWCEGQPEQCVQGAKQMIFWHQLEGTMSRSMETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWQ7</accession>
    <name>A0A8H5LWQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWQ7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034395972" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="367" mass="40843" checksum="363DC10A42E01C54" modified="2022-01-19" version="1">MLFQVLSSLLLTLTAGASSALLPRVDTPAPFNSSLFKDLNVSRGLNYHYYAVPADTGKPTLLFLHGFPSTSYDWRHQVAFFQDKGYGLLVPDMLGYGGTSKPLDPQLYVSSLVTRDIIDILDAESIEQAVVVAHDWGSQTASRLANYFPERFLSYAFLAVGYFTPTSFATPYEENLNLSKAVLGYENFGYWDFFSSEGADQTILDHFDSFWDLFYTNDTTKTITDFSPLGAYEAFITNDTRIPPVDYVTPEERAIQMEAIRQGGLAAPLNWYKIVRGTLEGQDDKGIPQENALIHSPVFFGVALRDYGSVSAPTFLAGALVSSNSTVTVREYNSGHWVQMAFPDEVNGDLLQWIEGLGLDQGVYKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXD7</accession>
    <name>A0A8H5LXD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXD7"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF15">
        <property type="entry name" value="O-GLYCOSIDE ALPHA-1,2-MANNOSYLTRANSFERASE HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="44652" checksum="E79B05C44170CCB6" modified="2022-01-19" version="1">MPISRPRLYLFFGLFIFALLLLYPAGKVVKQTYSAYSSNQELPDHQLQSSSTASGGKGPNGVIFMLMPPSRVHQAQLALLSTENRFNRRLQYPYVIFTVGEEIDKITEEDKAKIHWITEGRATFATVPLESWNVPDSYDKAKVEESLHNIGFSMGYRSMCRFYSGFFWRHPALAQYDWLWRLDTDIEFHCDVPYDPIQKVIDANALYGFVQINPDVDFVQPSLSGNVSQFLAANAHMLPHNANHGFVWNGKEGIEKALKGGAGNDEWTRMTMYNNFEISHKSVWENDLYKKFFDYLEQEGGFFYERWSDAPIHAFAVAMSLRKDQVVQFTDLGYQHQGWAYECPRLDRCTCNRDAVPARGFYDNAHAWFDAPSYNVKRTPKYVQDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AVM5</accession>
    <name>A0A8H5AVM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000536">
        <property type="protein sequence ID" value="KAF5311736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AVM5"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="196"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5311736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="553" mass="60637" checksum="832419505B00B6F9" modified="2022-01-19" version="1">MSLSQILFPSEPARITIKKRKPANSWLTDHSDNLQLPTPQPTPSPSPPLPSSSSEASSSSQPLTSAQMLQRKSTSQPPPAPTTYTPTPILAHGHGLRMHVPPVSSASAPAPAKGILKQKESLRKLIEENCPSLFEKFTSPWYLFNGHLQTLYNVVGDFSKEDHIVYRRTYLRLTDGGTLGLDFTPPDLDTLPEDTPIIVVNHGLTGGSHEAYIRAVLAPACTPRSQGGLGYRAVVVNFRGCACVPITSQHLYTAGNTEDLRIALLYISQQYPKAPLFGMGFSLGANVMVRYMAEEGDRSRLLSGCTMGCPWDLGENLTSITSTIMGNIWTRGMGANMLTLVQRHAPSLSGNTRRVLEEGEVKNPLSPIFEGRNIVAGAVEKALALRFPTLDKFDHTFTRVIGGVAVDLGPKEYYTQNGSHRVLPHIRRPLLAINAVDDPIVQSFPKTVEEIDSEWTTMVLTPGGGHLGWLEPVAWDLTGVKRWTTKPALEWLEMCGEMFDVGLQMRRLTAHTKVTRDKEGFMREEGTDGLGCKKIEGGGILDWSKMDISSKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AVY3</accession>
    <name>A0A8H5AVY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000538">
        <property type="protein sequence ID" value="KAF5311731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AVY3"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5311731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="293" mass="31864" checksum="8962B69858FD4883" modified="2022-01-19" version="1">MGPTSSSFVVIDGITTTLISTPIQIFMGWRIMVIMESLFPFVVITFLALGSLGGALALSITVSITPQFAKFDDFRAAPIIWLMTSALADVVIAIYLAKKKSNLSILNDQVDRIIRISIQTGAITAIGAATDAIVFIILPHSTVLNARNNYRYRNVKAGPTPNALFDYSEDTSTTFSLDPRTTQSRTLNDSIPMYSPPKTKIGISTVTETYQSPDVEMAPGGEHWRRPPQFPPPRIYTASPPPRGSSSRSSSRAENRVPAYSSNTTLVAGPDSGSQASRPYIPQPQPRQKPAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BI85</accession>
    <name>A0A8H5BI85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000390">
        <property type="protein sequence ID" value="KAF5323661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BI85"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034694903" description="Xylanolytic transcriptional activator regulatory domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="745"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5323661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135446" checksum="349C8EC4195E4441" modified="2022-01-19" version="1">MRILAFPSFFIFPSLHLLILLFLSSIIHAALSVSQQTDSNSPAYPSPFPFNPGFNIQNVASLALSLPSHSWEFGTASEALLELYNPELAVFAEDPFRQVHSQSRFQSIPSLTFASSKITLNLSSNAGANVLSDGDGATGDPASLGVSAILLGQGLGLGLSLGNSSTLGNNETRILEFREGARRMMEYLVNGAPRFENGAISQRADVAELWLVPWPIDRVSADFVYMAPPFLAYYGVSTSNLSLLLDTVEQCGLYRQILQLGSPSDIENNPNPPSQVDALDGLWRHIVGPQLPDPGLWSTGNAWAAAGMTRVLATVMKAPKKLFQSPISSHSLNLSESSSLNSASPQSTDLRSASINALTTYIKEILDGVVFTAPLDNGILRNYLNETLESGHGYGEISGSSLLASVIYRMIILRPEVFLSAHSDQKDSTGLITVWTSAFQPVDILVEQILNGPSSRPFTIPDSKESVRKILVKLAKRIRELKKDQQPLDSHDNSILGLRDSTEAYNFTPSAPIDTSVSKISDNGQETDSNVEDLSKELSQFSFGRERETHFGESSNIMLMKVAMEHNKELHGPNGPDWNSILACVRRPEFWEIDPVSEAIFSSSNAEYNASVKEPSYLISQHDLDAPVYNFPAADDLHRFIDIYFIERETYTPLLHRPSFEKSIREGLHHCDPAFGAVVLAVCAHGAKILSSSRQEEPGDRWFRQIHLGSFVFKQDLELYHLQLYCLMMTYFYGAGKGAESVDNAWVLAGIAIRRAQEKGAHRRRTSSSQYPTIEGELWKRAFWMLTLLDTMMSAYYGRPRATSVQDFDLDPLIECDDEYWEPQAEDGHQGFVQPPGKPSKLAYWNAYMRLIEIYGFALVTIYSVRKNVLGSKIGIGNGEWYEKAMMAIDSALNEWMGLVPEHLQWDKQHDDPIFFTQSTLLFSWYHWIQIAVHRRFIPRPRDRSTISLPSLAICISAARSSLRVCERFTKRLGNYHPQLVLVMYHSATVLALNLVRSLQLQIKIDPRKEIMDIYKFIDLLRFYERASPHAGRLVDILNVMMFYSPFLSQTTNTLGSMPEFNHPAQQPPTAQLQAATLSQPSLPLSSTSEIGTKPPVNPNIEGWSSESIQQLSSMSATSYMTTNSLLPSYSGKLGRHHIHEYSVNESSFASFDSPSANMNTSSLISPDLQEYFSLFDESTMVNTKTNNTVGDTPQSCPSTTQDWDSFMASIDQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BJB0</accession>
    <name>A0A8H5BJB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">APC amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000396">
        <property type="protein sequence ID" value="KAF5323197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BJB0"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5323197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="57997" checksum="63DC507027FEC224" modified="2022-01-19" version="1">MPASGGPMNTQDSIQQADEALLASLGYKQEFKRAFRSIEVFGIAFSIIGLLPSIASVLFYSIPNGGGPAMVWGWAVASIFIMFVGLAMAELASAAPTSGGLYFWTFSLSSPRWRNLLCWIVGYANTVGSISSVASINWGCAVQIMAAATIGSADSSFEPTNAQLFGVYAAIMVTHTAICCLGTTLLARLQTVYVVLNVLLCFAVIIALPASTPVEFRNTASFALGEFINFNGWPDGYAFILSFLAPLWTICSFDSSVHISEEASNAATAVPWAIVYAIGIAGVLGWAINMALAFCMGTDLEALANADQPMAAIFFNAFGTKGTLALWAFVVLVQYMMGSSMLLAASRQTYAFSRDGALPFSGWLYRMNGYTKTPVNTVVFDAFLALLLGLLVFAGDQAINAVFAISVTGLYIAYAIPIAARFAGDNDFEPGPFTLGVFSLPVAIVAVVFMLFLGIVFFFPTSPQTDVQDMNYTIVVLGGVMILSLVWYYFPKYGGVHWFKGPVATIEGFDDSSVLKKRRQGKVVDETETPATVAEESSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C629</accession>
    <name>A0A8H5C629_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_017382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000245">
        <property type="protein sequence ID" value="KAF5335251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C629"/>
    <dbReference type="OrthoDB" id="3250324at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5335251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="99627" checksum="7191B1599E3D7A68" modified="2022-01-19" version="1">MSRYNLSFSTEALYSTHSSPFMPPKKKADKQVTFADADANSTDPLQDSQPRRRKATRTWKAASSTTVANNGKEPQVVPSRKRTTTKTTRKTRQKDADRVADPPEHPQPLDQTNDDNLFFNPQTPVHVIPNKHSLRQSLRTPQTPRRNPSPVTPQRNQSPVTPLPRAQGCWPQPVSTVDNDGVETDIEAGLDLLSFISTPRRQVAGSSHQTPHRKTAGSSRQTPWHQASAPRQPATPRSNIRLHPSDVASPVFTTPRSGPHAINQKKTPTKKKKRHADDVWPFYEDLGRSGHRCKLCIARNASERETAVYSTNTASGILRRHLFTCHVEDWVDLCDQEGVDITAQEAQAAAAEYRAGAGASPSEHVPRLAFSAEAFVDAICAFIAADSQSINIIENPQLRAIFMMLRSGLRDSDIPHRDKIWSRIMQLWEDQLVHLKEDLLAALGRISTTMDLWTDPNLVPYMCVTAHWIQGKKAPGSDKFALMLRRHDGEHIARAYLYVLDRVGITEKLADDSAADYDPNAEFSNRDIIAIVRTLVRKICASHLRRKHFSDCLHAEKMKDYQLIRDVDIRWGPTALMIDRARLLKPAIKRFLAHLEFKELRRYYLTEIDWATLDRYSEILAHVLSGEKTPTLCFVLPAFEAMIEKWRALWDTIPQFSDAIDAGIEKLLGYIDRLNESNVYTLAMNMVADARQLFRDKLADYYIDLNANDQSTAPAAPISAPTPSRSTLWNPSWADELLGFAPLKDPSTSARKKATLQQEIDVYLSGELEDARGLDLIKWWEGSSVPSERVFSSAGEDTTKRHSRMRHELMEALQMLKFSLKRGTPINFTFGMKAEEEIDRLLVLLAEKDEALEDKNVCLQDILSMLDSKDLLEENLSDAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9G9</accession>
    <name>A0A8H5C9G9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000214">
        <property type="protein sequence ID" value="KAF5337580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9G9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="102" mass="11057" checksum="921DE4EC4033A908" modified="2022-01-19" version="1">MRMRMPIAYRHPVPASLSSAYANHLTIPALLSYPLLSASLLTTAAIYLRPALEARIPTKVQHSTNRYLSPISQESRNQETSAASVSDIHIPLFALLAAVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE95</accession>
    <name>A0A8H5CE95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_015590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000183">
        <property type="protein sequence ID" value="KAF5339654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE95"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5339654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36350" checksum="7D9DE76532ED6C7F" modified="2022-01-19" version="1">MSNHIRSATPPTSDQHSQHVASPTRLLPVNGITRSEQSLPEKYARAYPPVPESRIWRIRQWLREPAAEFAGVMILVIFGAGVGCQVNLSTNTGVASSPKGDYTTFAFGWAVGLALGVWVSAGISGGHINPAVTLSLAIFRGFPWRKVPVYMLAQLLGGIVGAGLIYANYFHAIDIVEGGRGIRTLTTAGIFSTFAAGYETNVSAFFSEFLATAILLVVILAVTDKRNTPPPYGLLPLVIFILTLGIAAALGMNTGFAINPARDLGPRMLMGMVGYDNEIWNFRNQYWLWCPVIAPTFGAMAGTIFYDGILFNGQESFFVRATAPPYLLEGWADDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGM2</accession>
    <name>A0A8H5CGM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_012290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGM2"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="254"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5341390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="442" mass="50820" checksum="F3BBCE98172BDF4E" modified="2022-01-19" version="1">MSRSRPLAFAHLLRHSPTNFYPFLCRCRCTPPSLHCSQPKPRSYSTKSSKVWLARQLRDPYVKARNSLSLPSRSAFKLMEINEKYGNFLEKDDVRVVVDLGAAPGGWVRVCAEKLAGIDPEKEKEKERREKKAKLEKERSEKKLKEEEEKAREQEDREWDEDAEEDQDEDEDEDGYNWDDRSIPMKRPRSQKLKKRDKVKMKLEEERNATRANPNATKAKDDVYDLLNIDDVFPPSPRSSRRSSSPSPKLSSKTKMIIALDLLTIPRTNIPSPDDIPNVRIHTIKADFLDSKTEGLIRDLIPPNPEDEEVDFGWNRKVDPDDEHPLETTPSTPKVDIILSDIAVNFSGNPTRDSETSYQVCLSVWEFARRYLRSEGGGRRGGVLVIKHFPHPSTHAFRMQTLVPNFHKVYYVKPEASRGESAEGYFVCRGLRDKETVEAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ99</accession>
    <name>A0A8H5CJ99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000157">
        <property type="protein sequence ID" value="KAF5342767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ99"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="17066" checksum="8888BAC6D4D8D932" modified="2022-01-19" version="1">MSLYIRVSSPPTPAPSPPPTATTAITTATMTTSADTTTTTKPDLSSILSILPTLPPEDLFKISEALGALIPTPAHRTAVDFLYTLPLELSLYILSFLSDARNVISVGLLCKKWNELSRDKGVWRRLCVGVGFSPHWPYHIPLSQGLSSRVPRQDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK28</accession>
    <name>A0A8H5CK28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000157">
        <property type="protein sequence ID" value="KAF5342759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK28"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5342759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="491" mass="53537" checksum="7EAB4A2FD40702FD" modified="2022-01-19" version="1">MDSLAKTQLIRRADPEYDRGDLAFIIIAGAMVLFMVPGLAFLYSGLARRKSALSLIWVAAAGNAVTIFQWYFWGYSLAFSSSATNGYIGNLRNFGLMNVLGNVSPGSPLIPELLYSFFQMEFACVTMCLLLGGIAERGRVLPAMVFTFVWMTIVYCPLACWAWNVNGWAFKWGVLDFAGGGPVEIGGGVSGLAYAWVLGRRHEKELINFRPHNVSLVSLGTFILWFGWLGFNGGSAFGANLRAIMAIWNTMLAAAFAGIVWCLLDYRYERRWTMVGFCSGTIAGLVAATPSSGFVHPWASVIIGILSGALCNFATKVKFLLRIDDALDLFAEHAVGGMIGLFLIGFFGDADIISLDGVSAVPGGFMDHNWKQLYIQFTYVVATSAYSFVVTALIAKGIDMIPGLHLRGSPESERLGMDEVEIGEFATDYIELHRDFTDGFAPAQGDHHMQFTAGDRHGQPETGLHRDSHDISTQPKSSKGLSTVEVKPTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLA9</accession>
    <name>A0A8H5CLA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLA9"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="34194" checksum="1C6A5CFE10C33098" modified="2022-01-19" version="1">MRISGAFGSAQTTTAPEPSQAQPVATAAGTTTTTGETSHHHPHLSSILSTLNPEERERKAAEAAALEAARLKAEEGARLQKQREAEEEERKHRFHPHHLLEKLSGEEGKGEGGAVGVPPAVPTKDEPKQAGGGGGGKLGLHKDDELASPPPPPPPPKEESFLDKLGLHHDNPAPPPPPPKEESFLDKLGSTFGHHNEPPALPPKPQTLGEKIESRLHEARHGKEEEEELKKRKEKKGFLNQMKVALGGEEAKEEEVDEDALGKAIDFVQEHVLHQGSQKNEGFLERMKDEQIASAVRKEYKKVTGKEFPGRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLV0</accession>
    <name>A0A8H5CLV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLV0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="207" mass="23218" checksum="D7C70D2E19D19199" modified="2022-01-19" version="1">MDSSSNSKTASASVATTSTSMSATPANKHRPAEESDQTTSCSSSRFTHEDWIRVSQFIHHVEPTIVRFWNNGCCYEISPWEVLVFLGHARKLKKSGYLAGQTIISPTYLAFAESFNDEKIPFKMPVPDTETGELLHRDGPIPPAKLFGFEYHKIVPHEILNPGRESVDSSEYQALRNLASRDAVRHQKFKAWKVLKRAEGHRVGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNQ5</accession>
    <name>A0A8H5CNQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000122">
        <property type="protein sequence ID" value="KAF5344604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNQ5"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="316"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="674" mass="75991" checksum="249F780876FC6C0C" modified="2022-01-19" version="1">MHERRGVLPWLSRNSGAVFLFVTVFTFLQLGFYAGNHFYAQEPSPSWWDSAKTSTLAAEGVVQAHPIPKLMEDAEAAYKKKVARQSRTLKDAVVEYRSRYGRLPPKGFEKWFEMAMEKNVVMIDEYDGLMEDLEPFYELSGLEVRRRSLQVGSLPSIDIVRIRNGVVKTVNLNKGFEDSEVGARANGFKSMINKVAHLLPDIDFPINAKAESRVIVPWEHRQHPNLTIQDSSVGIETMLGGPFIADWRGDGNVWDAWRRTCPPNSTARRLFSSIRTPFSPDSKNYLQSRDSPSSTSSTSGSSGSSVSSSLNSGVGPDFFFSPDTGYSLDYCNSPHARYSQGHFFSDWRVIPALYPVFSPAKARGFMDIKIPSHYYYGSTARYTYGWDPVNLELKDVDPMEVPWDLKQDKIFWRGATTGGGNNPPGFMPQYQRHRFLRMVSNISDTTRVLVFPDPESLLSPGEPSSTSSPTSKPPTNPPRYLSAPVPISKLNKEIMDIAFTKATAEKAYPGGLEALRRDHRFAEAVPLGRHWSFKYLVDFDGMSYSGRFLAFLASDSAPVKATVYEEFFEGWIQPWVHFIPLSTTYKEIYNIHAFFSGPPEAAIEAIKPNNSWDSDPNSSENRENWEEAGRTGYVHGDRDRDGDGDRAKSKKMYNADGDARLRRIARAGKQWKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQU5</accession>
    <name>A0A8H5CQU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_008507</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQU5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5345368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62972" checksum="9A9C5F9D9D9BDBFF" modified="2022-01-19" version="1">MPGILKTPDGSVVLQDYIFFTSLLFLGGLYALYKRFTRISISHVPGPEPETFVLGNLPELFQSQAAAADFKWQKQFGDVVRFKGIFGEDRLLISDPKALQYIMHTSGYNFPKWPERTEISRVLMGRGLLWADGDIHKRQRKAMLPGFGGNLPMLAPESKSFVPIFSRMSAQLTAQWTDMIASSPDQSAVLNVASWLSRVTMDSLGEAAFDYHFGALEERDNALMKAYFGLMSDTLGRPSRSAIFMQTFMPLWYLRLVSQYSRSRRMVHARHTAELANDIARELIAMKTEALTTGKEKKDILSLLVQANASENPANRLTEEEMFAQMRTLLLAGHETSATSMTWLFLELARHPDVQSKLREEIRVTEQSIHDRGRSNFIANDFENMPYMAAVIKEALRFHPAVYANYRRPARDDVLPLSQPIRATNGDILTELPVAKGTKLVLSLAGYHRNKEVFGEDADVFNPDRWFRDTAVKKGRSLGVYGNLLTFAGGIRACIGWKFALCEVQATLVELINNFEFAPTEDLKRLRREACLVTVPTLEGEEEKGENLPLRVTIASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTG2</accession>
    <name>A0A8H5CTG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_011652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTG2"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5347064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="944" mass="103494" checksum="FC48FFD95F1C41A4" modified="2022-01-19" version="1">MSKQLDNKKKSKEEVQVDLVEVGGVGEVAGQKQARRSTAKSVLLVATCTLALMVHTSNNIAISITLPVIQRALNVPQVQLQWLVSAYALSSGCLLLVFGRVADIYGRKKVFIFGSSWLTVFTLGCAFAQDSLTLDILRGLQGIGAAATIPAAIGTLAATFPPSRARAIAFSTQTAGLMILYNNSFSSGSPLGATLGTAVGGVLNQKTSATWKASFYLNCVLAFVSVIGAIFSFERDKPSLASDRRIDWFGAFTVTSGLVLIVFVLGEGEVAPQKWATPYIIGLLVTGVILTLLFGFWQHYLEQVHDDLRSPLPWLPSPPPLMRLSLWTRSKWRVTVVMLIALLNWASFLGWNFWTVLYYENFSSLTPIATVLRLLPQFITGIFCNIIVARFVGQVPLVVLIAAGTSLSGVASLLFAIINPNATYWAFGFPSAILSVFGANFVFASGTLFISAVSAPSEQSVVGAVFQEMTQIGSSLGVTISTVVFNRVLQQTASDRGFRVTNSRGNGLPRDVQLKAYQAAEWTNFAFGMIAIAFLSSVGIVGARRKPEGLVLDEAVDGSDNFEFAQKADASVPSTSLTNLSQPVPVIPNEIDTAIPWHHLRELDLASCNLQTALRVLLNCAGNLTRCNLGQVTFGDIQTEWTPRMTITMFRLHTFSLHLSEAGPQLLDCLTLTSVYDLTLMEIKASQSIDNVINLLVRSACYIRRLKLLDFPLMDVTLIRLLRRTPGLEELELKGWIWNDLWLNMTRSTSPSVINPVVPHLKVFRLYGRRIFHVEVLQTMLNSRIVGGSEEFQLGDPDEDASRLQDLDDEDDDQRSAPGRLGSPSNTNGTVVGEILVDVKNTRSPVILDARRTKANTKEAADMAKNWNAALSDTLLAKFDINVENIGIIDELLTEIEWYSRSAEHFIGSSILRITLRAIAQRETPQSREVDVRKRTSSLVKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUU1</accession>
    <name>A0A8H5CUU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUU1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="93" mass="10101" checksum="03FC403518699597" modified="2022-01-19" version="1">MEETKYGVRNLTAFVGAPTIAKILNKLNKTSASATTENQSMVLLGPWAPLLAQEHPVLNLILSMSTPLRVHSVLYVIAHLVPIIVFASVLHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXJ6</accession>
    <name>A0A8H5CXJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXJ6"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5349790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="505" mass="56921" checksum="B2105B0F0756E493" modified="2022-01-19" version="1">MLSRLNFLRGYQHLQNHDDEHSYPIPMSRLPSSTRPYHPPYSGRSSVLKMALRHLSFRQIAILAAGVFLLICGIILSSGIPPCYDDIWQYERSLPQYNLTEALADVKSGKRKYLWFEKNVEGRGLNNVLQEALIMNYVAYSTNRAFVFEDYVWSKNSPFSSTVSEWSLTPSRTPLSAFISGPTTGGPFGRDSSIATRSVHLDFFNSVCPPSARTVVSSADSPTDSGGKELVDWWVDKLSSVESDPCVVVDSSKEIFDFHFFGSSKHVVSVFELLRRSPILTDFSWSPLVLSAILRNFAIFNPPNLKDLHGTSQHATMKGLVAVHLRRGDFQGHCKHLFKYRSLYMGLNTYPGILDSFDPEVHLREAMAADKIEGHQRNEDRENDILRPYYQKHCFPSIEQIVQRLRVIREENPGSNLNRVYALSNGHASWLRELGRQLKADGWGDVKSTIDLRLDGQQKYVSGAIDMAIAEKAEVFVGNGFSSLSSDVVMFRLTEGIPASSNHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZ68</accession>
    <name>A0A8H5CZ68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZ68"/>
    <dbReference type="OrthoDB" id="2654851at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="180"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="465" mass="53074" checksum="BA58F1243E4C2F47" modified="2022-01-19" version="1">MSDHWQFASRFMPPLNKTSPMVSDFGSPLVSDDIWDITTENEAERRKLTFELKALNGTTKSSANAGDNWMKDFHGLWATPNTFARDGKNQLLMPNTASSSRSSSRTEFSMTGLETASDYSAIITPFGSAVIPVEESCAPSSIHLGSPLPLQDDPKMPHCLINTISLQLTEFGKDDPIPLYAILSHRWGKQEEEVGYQELKRPTAETFRKAGYYKIALACNQALLQHGLQYLWVDTCCINQHDKDDIHRNIKSMFAYYQHSYICFAYLVDISGHDFLRSVWFTRGWTLQELLAPLDVIFFDCNWQAIGRRNQRSWEISIITGIPEDVIKGETRIYEVDVEEKMSWSAHRETSRPPDQAYCLFGILGVSVEPNYDEDAETAFSRLCEAWFRKISEESGGRKIMVPNLGRLYGSLRSRARKGREAWSYRGRNDEGRIMTRKEDVVGTSSTRLKPYIPHLDGVMQRLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZI4</accession>
    <name>A0A8H5CZI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZI4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5349447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="272" mass="29602" checksum="2092DAEA4A18EA53" modified="2022-01-19" version="1">MLGGRKEGADDAARIDVFIPIILNEVKDAGVGNLGLQDQREALRWIQKYIGAFGGDPEKVTIWGESAGAISVALHMLNNGGDTESLFRAGFIESGSPIPVGDITNGQKYYDDLVDQTDCSGSNDILQCLREVPYAKLKDAVDNTPNIFSYQTEFLSTISDEDLETLLQAYPEDPARGSPFDTGDLNAISPQFKRIASFQGDAVFQAPRRWLFENLDGKQPIWAFLSKREKAVPILGAFHSSDILNAYGGGGMADYIIRFTANLDPNGNTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZJ5</accession>
    <name>A0A8H5CZJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZJ5"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="178" mass="19519" checksum="2EFAFCB66221F3A7" modified="2022-01-19" version="1">MSSSSERQLEGRIALITGCSGGIGKASAITLARRGCSIAVHYSQSADRAHALAEELQKSFQVRAAAFGADLSNYDNVRGLHSEVVQKLGHPDILFNNAGDTVKVIGRMGNIEDISVDLFEKTWKLNTGSQFLLTQLCLKHMVEQKYGRIVFNSSVAAGKFNRSHLVDYVLISQELMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1X3</accession>
    <name>A0A8H5D1X3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1X3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="174" mass="19281" checksum="DA852DBD5CB1F987" modified="2022-01-19" version="1">MSTSPRTTIAIMLRLQSPRPPTGKSVCPPTTHIDYRRSHGPPPPPPSPSPLRTPSPTGKSVPLPSPSRLPTNLSLFYRLRGFRAKSLPLFTPPSLSLSHLSLQNHPNTLNGIAVRQRQRQWIPENVTVAVGMGEGRKIRTVRFTHTTFNEMNDCVLGVDEDLFDEADSDWKEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D250</accession>
    <name>A0A8H5D250_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_011947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D250"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="11">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5352279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="21403" checksum="8E8CB16EB6D97BEA" modified="2022-01-19" version="1">MKHSIEHEFTAPYTSPSNGVAECRIGVLLEGTRAALFNSGLPPSWWGHATMSVAYVQNIFLNASGNVPEELWTSQRQNVSYLIPFGSISFVHIPEKSGQKKLDARGFKAQMVGYAGRKVYVVKEWGSNAVYHTSDVVWEKSNGHWVSEVKGKDEDLEFLTLKTLDDANWNPNQTAAKYNRDQVTSLNPLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2I2</accession>
    <name>A0A8H5D2I2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2I2"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="364" mass="39130" checksum="0386E21BD1A64589" modified="2022-01-19" version="1">MTRGPTNTHNKRVSIDDRKGQDVRVRRDVEASSSGHNVPSQIQPQIEGVPLDGGRTAWLTILGCWMVQFCTIGYSNAFGVYQDFYTRVYLTTKSPSDISWIGSFALFMQYAPGVFVGHAFDAGYFHHMMALGTCFQVFSMFMLSLAHQEQYYQVFLAQAVGIGFGMGLIFIPSLTIISQHFRKRRAFATGIAVTGASVGGIVWPIMLNHLIQITSFANAVRATGAVAGAMLLLANFIMKPTKPTKSTKGLGLIPRRFGFGDGHEQQPEQEKVQAQAEGAGRQRGSDSEGSGDSGCVSGSGLTSGPSPNSALESCQSHTRVGRRRFSIISNASLVPGFKMGFGTSPGPGLKDILSDAPFVVSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D338</accession>
    <name>A0A8H5D338_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D338"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="592" mass="67321" checksum="A7B7201BDBC5246C" modified="2022-01-19" version="1">MISKLCVKCRADLFTKEPSRCPVDLHSGYVPNERDIARMKSFIQDANADISELDSMLALLTERRETLVRQVNDCKRVISANALRNFPPEVLIEVFRLCTPSLDLFYSTHDAFSATLLAISQTCAFWRNVSLSTPELWTNIFIDITSCPDGPNYHSLLKLYLSRSSSTPLTLQITARVTQYNLPFSLADRGEFSAQQRSMLEYLPSQFHLCAHLSLDLHSLVQRDIILPSNFHILQSLAIKTTGFNGWNPPDVDVLDYLTNVPNLRSLETIVYTDRGPLIYPFINNLTTITLHFLSRASYVRSLLEKCPHLRHANIELRGLETDEDINSESAAIQVHHALRTFKINVTNRAYHLPNPLHWVLCAVSLPNLTELEITDKTVAGGKGLCTALTVFLLNSPLLREFGLNATCFEWDRELIEILRLSPTLARLRLEIEDKHPALTKQFFHDLSFQNEDEDDGDCHDSPPVLPCLEHFSLDFIVYVETGWGSSGYLPPNAENILAMVESRVRRQPSAVHRGQLRSFRLSALLNTLDGFRWAEKAIPLFKAGLQSLKLDEGLEFDVRFHNHLVKYRDVVVISSSAEKLESQYRIRSQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4T2</accession>
    <name>A0A8H5D4T2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4T2"/>
    <dbReference type="OrthoDB" id="2799438at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12745" checksum="41803449EE695F4F" modified="2022-01-19" version="1">MIDIPVGKPRPFLIRRYGNPPSPVSQCKKRIDQLTDTLYDSNLRCEALSLNLQAASYALESAERERDRAVEEHTKLRKEVVGLHCELRRLQDRIKTGGWDLIRLSDSVDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4Z5</accession>
    <name>A0A8H5D4Z5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4Z5"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="642"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="85"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5353691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119772" checksum="672A95107E8975AE" modified="2022-01-19" version="1">MPEASGEEFSSARFRERDKHILQKHQAQLDELRKSLDSCKRLKEEFQTRWFNLRNASERVAQALGFLDIAEVQDCIDSFGEPVQLRECLERNKRLEKDNDNLNERNGELSDRVLILEEEKARLREENERLRSQSEENRKASLELAILREAYDDLRRAKHDKDRQYDEMYIKFQKFKDWLFGTKRPEQSIDEFWEQMSLALKRRWTTVARLGHDVKPDHLMNLPQQEINDASPVMADSKSKTSHQRQLSVAIPLAPLSPSKKANQEPSSPCSSAATRPTLIAVKASSNDDDDDVFLNPNTLHTPKGSSHGLTRTFAFATSGAGPSNATEATILVPASSSPTVRNTEQLHEPTQRSHSPASSETEPETQPFWISPQRPKPPPPSTTPAPPASGSSTRTPLVFEPVGASGSPLSKSRSNRRKSDIGTSSSSSQNDDHVRKYRRVSEGNNTSASASKRTPVVKPVAVAVKVEEEDMVDLTMEPSSSPSTNHGADVSAAGSASSSRRGKITSQNKENDSRRLASTLKEQTQTPKGRGIVRENATGTVRGKGKRKERQRDEEMPLVTPGAGTRKSTGKGKEKQRDGPGKPMPMSTPGSAARAKGGVDYSVYKGRGRYGKEAAAAKEQDKTMNELYAINLERNEGLDYQYHEVVRGKEKRKRLDAGDCESCKAYYEAIGPMPPRLQAPLWRSPSRSQSSSNDVLQRPRPCPHHSSDDIIDIDDSDFGSQAPSTSKHASTSTSSTTNRREREKEKEIQSHKQAISRHRDNWARGSTPPMYWSIGFPNTQEAEEINEQAREQHRRKMKEAAREAERKDGSTMFSYALSFWMEFTLNTVFAHMYMGRHARLRGSLGNQGRCRIFWRSPSRLCAPLRFEFYFNHHYHLLSGLQSKEMISQDDSYGLQWQRDSKPVCSTTYPHQPSMRRRHCRLVRMSHAIRKNTLIIHSFRRRRSRRRHPFGTKHLFRAQKTLYRARHCSTTSLESDDYPPTIQLPRLLHVEPISPPADQSSFASGIDRSFGGDGDGSAYENNKATAVPAPDIDDLLRQLVPERANKRYCLPDFLCPESAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6G9</accession>
    <name>A0A8H5D6G9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6G9"/>
    <dbReference type="OrthoDB" id="3057032at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="459" mass="50365" checksum="A606E718ED1BA443" modified="2022-01-19" version="1">MNTIPMANITAPDASSRVRSAEPKDSHPLADSSMPSSPSPQTRLLETSSSTRSSSDDSNSGDPRPSPTPSPLYRNQSSELLSASSKGFVSSPLNPSPSSSPPLFGPNRPIARPNFPRVASEDVRALSMRSSRASSMVLYRLADAPGELGLPPPIRGPHDRSSVVSSSGDSIISLSSDSKYPSNYSTMSDRGVIAYAYDPTPDDVDFDDDEFHNPKLDQHPDRISTRGIVNISALILVMLGIMALFVVYPAYTITRGNSGPEDNTIDSCVNDIGQIDESRLGCQPFRVQSQVIENNGDENGMTKRDQIPMSGLLGTHEVEEEPLTNGDSSIFDFVGIFVAPFQETVLELPICAEDDELLVQVRFRRPGRDHWEIAYWNHGDWASLTEANREQLSHQPARRPRRSSWKYSVLEMHLPSVSGDEVEVDSILVSQRTSPSHTQTCEGSRQRRQILDISDVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6H2</accession>
    <name>A0A8H5D6H2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6H2"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="29762" checksum="4E5B2A595C32C1BD" modified="2022-01-19" version="1">MAKSTSVVSDSDGNPRDASELLNDKAGEEERENGVGEDEDEEEYEIEEILNHERNKFEGRMGYFCKWKGYGPESNSWVDEEDAGNATELIEAYWKKKKTGRKSADHSTKKGRASAVADSPEPLSAPKKRGRKSAVAKDEEEEDNQAVKRQKTKKTTRKKIETPEPEDIVMEDSEEQIADGKYMTKFMSLSSWEEIVGTIDTVERPSEKGPLMVYFRLKKEEGGNRVRLPSMVCREKFPQALLDFYESNLKWKETEVDDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7K4</accession>
    <name>A0A8H5D7K4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7K4"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="2">
        <location>
            <begin position="474"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117248" checksum="C12C2E8A3E0D6C46" modified="2022-01-19" version="1">MIIDAITYPPRDGYPLFITAKRYTLSEFKVYEDDPDALTLICLHSTASHKESWEPTLAKVFGLASEGMKTRKGDPRREVKIREAWCLDCPNHGASAMLNERILQTPEYYLRFSCELYAQAVLHFLSAGPEYGAKVDFKARNLVGIGHSLGGNAMSMLQTMTPRIPFISLVLVEPMLSPAGPKHLSGLRSLLIKGAYERRDVWSNRKAALEGLPRRDRTKKWDERVVQLFIKHGIRPHQGSYYLESPYNGVTLACTRDQEAAMYRDPEGGTKPVESLNKACQEIPVHLVLGGVYDFLPKRIHDALVDPKSGRRFASVTVIPESGHLVPLEMPDRLGEIIYGAFVQNAKQGPLKANLVFDNHSLYSQTRLATKEPLSLSRDCGKTRRTCMSEFSNPNPIFTAIPFLPTVICRHCLGLPMANDDRNDSSLHTRTLKDPIHDQIEINPTLSSFIDTRQFQRLRNIKQLGTTYYVWPGACHNRFEHCIGVSYLSRLLICHLQTSQPELGITERDVTCLELAGLCHDLGHGPWSHVFDSMFIPKAFPDVPPEERWTHEKGSEDMFEYLVRENEIDISDVDKEFIKALIAGDWKRTPDEKRFLFDIVANKINGLDVDKFDYIARDSRMVGDGVNINIGRIVKSARVIDDQICYDHKDVNNIFDICATRFKLHKNLYNHKTAKAIEYMIVDILLLANDHYKIAESVSKPERYIHLTDCLLEKIAASEEEELKEARQLVRRIQTRNLYRRVDYRFMPYDLVGPAKKLITSQKIVDAVQQLVDSGKIEDLDPELDVAALKPEDVIVDFSTMHYGMKEKNPVDNVRFYSKRDLNKCYPAREGDYSSLRPTVYAETVLQVFTKDPDFFGVVQAGYRHVVESLGPEALMTASVAADTVAMEEERSPSPVPTEAPSTPGPSQSGPSHSTTITPAASLTNVLTSSTNKTPQQLSLACLQRQNVFTTVDAKFQHQSPAKQRQKPRSTSGRSDAGGSGVTGATPSGDAGSDFAPSILPSAESAGSAIEMANLGDKRSRYNVFMEEPGSPSPKRRKSVAKPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7V4</accession>
    <name>A0A8H5D7V4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7V4"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="10565" checksum="17C9164B3B9BDDCC" modified="2022-01-19" version="1">MSYRILGRQVKNEHIVLTVVSLLGAGVFAATRGGDQKKQIPPASSSVLDKTVDKLKEVKEEVKEAVVKPAMSEEEEVLESIRKFIADAEKEDAKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D878</accession>
    <name>A0A8H5D878_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D878"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5355487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="33001" checksum="5A0B8281DC30EBD3" modified="2022-01-19" version="1">MEETVTAKKEIILSAGSIMSPSVLQHSGIGDADALSALGIDVVHNLPSVGQNLTEHPLLPSAWQVKATDTWDDLFRNETLLEETLLEWSQTKSGVFTHPPLSFLGWLRLPDNSSIFETVEDPAAGPDTAHTELIWINGFVGPEPAEGNFLTLASAVVSPTSRGSVTVNSSNPLDPPVINFNILSTDFDRFALREAFRSSARFLEASSWPDFIVAPPTNATTDEEIDAFIRENAATIFHPVSTVAMSPKDASWGVVDPDLRVKGVKGLRVVDASVMPMIPAAHTQVPTYLISERAADLIKEAWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F945</accession>
    <name>A0A8H5F945_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000364">
        <property type="protein sequence ID" value="KAF5328301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F945"/>
    <dbReference type="OrthoDB" id="3250324at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="774"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5328301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="894" mass="100937" checksum="A4887107CAA98886" modified="2022-01-19" version="1">MPFADYDARTAGSADTGNAAIVIDEQATATQVPTRKRKTGQKTTRKTVQKATRGSKRVDHPEPPQQLDQNEEDDIFFNPRPDVGFLRQTLCTPQTPRHELSPSTPVPRGRGRRSQRVLNIDDDAMEKDIENGLDLLSFVATPCRQATGAHQTPRRQAPDSRANSRQPATPRSNIRLHPSDIALPISMTPRSGPHATTRKNKTPPATKKKKRRADDVWPFYEDEGSRGQRCKLCIARNVSERQAVVYSANTASGVLCKHLYMCHVEDWVDLCDQEGVDITAQEAQAAVAQYRTGAGACSAEKTAPRLAFSPEAFVDAICAFIAADSQSINVIENPQLRAIFLMLRSGLRDSDIPHRDKIWSHIIQLWEDQLVHLKEDISAALGQVSTTMDLWTDPNLVPYMCVTAHWIQGNKAPGSDKLTLTLRAELIGFHRVPGRYDGEHIARAYLYILDRVEMTAKLGYTTMDNASNNDTCMQVLETDLIMRGLDFDANEQQVRCFPHITNCAVKAVLAALTDIKLADDSIRASHLRRKYFSDCLRAEKMKDYQLIRDIDIRWGSTALMIDRARLLKMAIKRFLAHPEFKDLHRYYLTEVDWTMLDRYSEILAVPQRFQHVLSGEKTPTLCFVLPVFEAMIEKWKVLRDTIPQLADAIEAGIEKLTGYISCLSESKVYTLAMILNPAMKLRWLEHYHPDMVVDARQLFQDKLIDYYVGDNANGQSQTPAGVPIIPTPAISRSTLWNPSWADELLGLTPLKESSNPTQRKSRHYSKKLMFIFPNNQSRFPTLFCLAMDILPVQGSSVPSERVFSLAGEDTTKRHSRMHHDLMEALQMLKFSLKRGTPINFTVGMKAEEEIDRLLGLLAAKDEVLEDKNVRLQDILSMLESQDSLEEDIHHAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9D9</accession>
    <name>A0A8H5F9D9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_019071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000371">
        <property type="protein sequence ID" value="KAF5328033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9D9"/>
    <dbReference type="OrthoDB" id="3027122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="878"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5328033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="991" mass="111217" checksum="60BCFC7F0845AD25" modified="2022-01-19" version="1">MKKQYQKLRDRFSRSRSRSRNRSRSPIPPAAVSAPDPPVHNSSLTPSYLTSSARLSPVPPPQIGASAIQKPLPDLPGNNARDGKSRLERVTQSTEFRSMKTLLKLVTAAGGAEPTGALKIVSGSLSILVEQAEKTVQTSADRKAFMKSLQSAVDNLEHYSRDVTSGSLGEHMKTLQETLKNKIRQLMDELERPWWKRFLAAGEEAEDMKSLQQMVRDMYQVFMMELAIQIAINIENGIETNREIKAYLEENLRDLKTGFKEVAREIKGIKLEMLKACTNQLTGCLAPSEKAEYNAMTSVPRGACTKGTRQEILEKLMAWAEGDTDHPIFWMNGMAGTGKTTIAYSFCLQLLEKQMLGASFFSSRSEGETADPGHVLPTIAYQLARHSPEFSAALWKSLKAEEDSGCTPSESQFRKLILSPARTSRSAFGQKHLVVVCDGLDECRDLSQISKILSLLIQHAVDLPMKFYISSRPEADITARFTSANSKHHKKFLLHNVEEHFLRRDLGLFLHYRFAEIRSEKSISEEGWPSEDQLNQLLDLSGQLFIYAATACLFIADPRIQSPGSTQKALRDILSYSASNPTPGNEASYRELDALYRIVLSSALHNDEENEILKNVLHLITTAQTPLSQTAITELLQIDISNILLERTLSSLQSVISVPANHSQPIQIFHASFPDFLSDPIRSKEYHHAPPESHSILANKCLEYLKGHLVENICGLQDKNVHVSQATIAGNISEALQYACMYWITHYLEASDKDTLHELMNKFFQEVDAKIRRLAGDTRRCVLQCFNTIRDHPLEIYYSALFWLPKKSIIWEFYPQEIPWKLLGGVGNVWECYDHVIQAKGSIDCIALSADGQQVVSGSSDSTIRIWNVETGEEEKKLEGHSDWVRSVAFSADGQRVVSGSSDKTIRIWNVGTGEEEKKLDQHSQSAANEQKIATDVSHYLHDQWIHHPFIGELDCVYLPFTDIFCSAIHDDIRLLCLGFQSGKVLILKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FE09</accession>
    <name>A0A8H5FE09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000291">
        <property type="protein sequence ID" value="KAF5333043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FE09"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034458629" evidence="3">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5333043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="37964" checksum="AAAB253A0B26E9F7" modified="2022-01-19" version="1">MTPLTACWLLFSLRCRGKVCKPYNSVLGEHFHAHWDVLPLIHNNEDPLIAQIYSSTSSVSVPALNSDASLIVSCTTNNVKGGSGPGGFRAVVEYKEESWLGKANFRIEGVIHTVPGSGSSPRASKDSSSADADTDSSSSLSEDDDDDVDDADENWEQWTKVKHVPPSHVVAVLEGSWRGEIRWKRVGSGSFTYSGNKSTNTTQHNQHAYTAPSSPNPSHTALPNPSKHPKSNIAESKGDLSLPGTTQDSKDSKGGTKGTMGTGKDKDKAKGEEEWNMLIDLSTLFPVPKQVRPLDRQEKYECRKLWEGVTSRLLKEEFSEATKEKVVIEQRQRDEAGERRRKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEY2</accession>
    <name>A0A8H5FEY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017530</name>
        <name evidence="7" type="ORF">D9758_017538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000275">
        <property type="protein sequence ID" value="KAF5333996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000275">
        <property type="protein sequence ID" value="KAF5334003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEY2"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5333996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5334003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="145" mass="16125" checksum="35D92FB7170C3918" modified="2022-01-19" version="1">MALPPPTKDQAYCKVSALEASEVQLSLAIFLTEVDNPDPLTGEKALAPSLSFLFHHSKNHKKFIFDLGVRKDFENYPPAVVECWIKVFFPCQVSKDPVDCLTKGGYVPNDIDYICLSHLHFDHVGDPSLFPKSMFLVGAQGKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF44</accession>
    <name>A0A8H5FF44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF44"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5334840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="45692" checksum="E43F0155CAD462BF" modified="2022-01-19" version="1">MNMELPLKRALLADSRPKLETGNWKDFHYHHLYHSTPHFIPCLKMKLPDFDAWVTADDVPLAEYKITMAEKKVSCWIPSEVGKVKRPLMRNFASYMYLDGQLEYARAVIIDANGTSEIYNLSGLLVSETSERPFVFQSAESTDDDAYLAHEANLGEIKVIIKEVIIGAAIPVPKPTFVPQAKIHERSNKAIKHQIGLGAVETIPIQDYFALEVVRDIGTYVFRYRPIDFLRANSVVPPLPLHSETKKSASPDGPSTFQKQAMIQLAALRKKTVKRIKQEPKDAIIPSQSALRLLHPSGLTTNGSVQAVQVTFPPPRDVQAMPFEAIIPSSGPIVNVPIAEFAEQFKNDVDEEIITKLVGSGYKKIRTLRRLTTEKLQRMGLSDGQVDTLLDAVGDFVEGYDDINYHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFI4</accession>
    <name>A0A8H5FFI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFI4"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5334558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="45549" checksum="10AB1AFFE611363C" modified="2022-01-19" version="1">MSRVSVRKLTNPTNSEIEAAVTVMNEAFDGQRSIELFTGGDKSLVTPYWRANILAALHSGEVWVASDGTEAIMSIGIWFGPGKELYETKEIESFLELVSHETREWWITKVGHKAYRPLCLKFFGDCLGVKTRIDNWFANVIATHPRYQGRGLATAHIEGIHQKVMREGSYLALGTSGESQERFYRSVGFWERGRMKSEPSDLICFFSRSTAFLIFAITLKLVLLSVVNLRRAEIELLSQRAQSYSYLGDDYPPTWNIGKITTVKLMHGDTSHYELEGPIADMEWDALTPNNGTVYLGPKKMSFSVSMFHQLRCLNIIRKESNRKRHLEGDSQDEGGRTGYIPSELANHCMNYLRQMIICRADTVLDAVKGIPRVDVLREETRCRDWTQVYDAAEKAQPGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGF8</accession>
    <name>A0A8H5FGF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000236">
        <property type="protein sequence ID" value="KAF5335864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3249498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1311" mass="148946" checksum="CFDDBE6EB26F5E35" modified="2022-01-19" version="1">MSETAHAAVNEAAEDHGNEVPSREGSVDNGTEIPTDEEQEELQAIAEACDSLVDDYQARKITRGYLEESLHVTGASDNAIKDYLRDVDSHFPAGRDGLRKYVRGEIDERSDGDDRGEELGLDREKVKRAFAAAANAVEKGEAYIRARREREQRETRNDASITAEQFINDALGLSASLLTAAPHLGDLLSLSKDQHLRETQNIRIAVSKESSLKTLVQILEFMPLKEPISRGTWEKIIKDEYVDFEKLHAFSDPSYDRSDESKEIVPGFFISRKDTATKKKIRTEAEWYRVYEQWSAGVEAVYKHRADELREYRSLISEMFKDYPDHIDVVIAVDAHARFQYSKKPCHLDDNQRLERFLHSKLSQTKSSGQSSLTTSSSKRTNTSESNPRPMKQRQYEICLNWNRAFVEEDTGPRTSQIASANIMPEDSELSLIDKRVQLALGGPRRVSNNTASAVKRKAPQSSHPRFRRNFVWYDSEDEVVSPSVIFSETAPPLPSVPDKLLTDPEVVAALHAQRDFIQVTTPYNVDRLRNLLSLHPNQPFVESVLKGLVVGFWPCHSGEWEEGFDALMENYHMEEPDLNVVRAYRDKEVAEGRWSPTIRSFEKGMKSSPMFVVWQGEQHAKGRVITDFTGSGINAGISQEEAHVKYDDMRSFGLALRQARLAHPGKELILFKDNIKGAFPTLPAHPIWQLRQVVTVDDDLHIVRRMVFGGRSTPRIWCALSSLICWIAVRRFGIRGLHVYMDDFFGWDLASNLLYFRGHLWPQKQVLLLIIWEFISCPFEDEKQDHGPMLKIIGFWVDINKGVLSLSPSSIKDLIARVSEFLLTEDCKHPLCSWWRLSGHLNWSLNVLPWARPALSALYEKMCGKSIPQASIPINAAVRESLEWYLSILPSAIGVKFFDEGTWRDEEADMIFWTDSSLTIALSFVFAGHGYVYEIRPPPSTVKIDIFFLELIAILSAIDFAVSRPSPPKQILIWSDSLNSVSAFDSLGTSEHIHTCVMLAVAGLIIRSGIDVRAHAIEESTLAGYKTGARDYVTFCINHHLSLEPTISTLCRYIAYTSQFIASGPDYLTGAHHFLREIYPEFASNRASHAVQATIIGSRKFRADTVQRKLPLRTSHLNAFYDLYLENPTYDNLLFITILSCMFYGVHRAGELIAKHHTNSRKIIKRSSLKFEKDRVSYKLPHHKGDRFYRSSDILLGNHSSANPVSLLRTYSKIRDSIHHHKFPLFLREDGSLPTRSWFEGIFFKLVNREYGGHSVRAGGATYYASLTLSESIIQALGRWSSDAWCIYIRDHATVWAEIQLATIRHSDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FH81</accession>
    <name>A0A8H5FH81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FH81"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="120" mass="14049" checksum="2223EDECF1CD9B32" modified="2022-01-19" version="1">MVLCYSSYHLHLQQQQLRSHLWAAIRIWIISLKEAAAWEALFVYDSLLFAMIIIKGYKNKRSMERMPLLQMILRDGVCEASGLTTAKIKIFSFSALYKRRSINLFRRHVVLFSYGNPGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI71</accession>
    <name>A0A8H5FI71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000200">
        <property type="protein sequence ID" value="KAF5338125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI71"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5338125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="738" mass="82274" checksum="9B9F43879A6B8CD9" modified="2022-01-19" version="1">MSTDSFPSELEASEVQRPLYFCPPSLYALVIGINAYKHHDIMDLKGCVKDTEDIIEFLKGDLGVKEQNIVRLLNQDATRANIIQRLEDMAKTDMIPRDSAILIYFAGHGAQHTAPLSDNKDKKIQMLLPHDFIPRTNADINAQGIPDAKLSALLSNLADAKGNNITVIMDSCHSGSGTRSDDVTKEHSVRSIDLPHDYDILPSILQHAGRSMNVAAGHEHDGLASHVLLAACSRDGQAREIYQRGQFTKALTTVLRDPRHYTDTISYQDVIRLLPDLSLQVPQCEGKYDQRILFKGIAPKRSRRLWSLKSSHETFTIDTGEAQGVTEAARFAIYPSPDMNSHVITYLVAEKVSAYSTILRWSSATDAKPPIPPSAWAVQTHAGKDVNIPVAFMFEKTSPAVFQHIIDILNQNPGRKVIPASPEVAELVVIEESGRAVFHLTDHICCQSKLRCLPSSVSFNAENIYAILKHVAEFFWALRHSKKLVRTPSSPHSSLQLCVRIEAWKLTVKYAESRPHLTPTGENLNVCGVIQIPIVDGAPPARYGFKIISTHNRPLYVWVFSFNMSDLSIHIIYHPNFSKTADPCLSPRGELDIGYGSGGSRPQSFYLPPDMTADVSYLKVFVTTQFVDFSDIEKLSPFEPGRKSMPNRLGQSQPEMWDALLVPIIQSRIGRGSKEEDKAHPDAAYAALVMRLSEEAVNDVMMVSTLDRDSRSMIDERLPSANEQGWEFEPVEKFSRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FII9</accession>
    <name>A0A8H5FII9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000204">
        <property type="protein sequence ID" value="KAF5337857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FII9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24290" checksum="5F86A143C860918C" modified="2022-01-19" version="1">MNWTHSSAKATAESALPFYYASMVNLPNMILLMIENREDVNAQGGQYGTALQAASRKGNVDIVKLLLENGADVNAQGGEYGNALQAASAQFGGSVDIVKLLLENGADVNAQGGKYSNALQAASSKENVDIIKLLLENGADVNAQDGLYGSLEDNVDIVKLLLENGADVNAQGGVYGNALQAASCGGQVDTVKLLLENGTDVNAQGGVYGNALQAASPLGVPSSRYLWGHPTPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKS3</accession>
    <name>A0A8H5FKS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKS3"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35957" checksum="589C52A4838B8D47" modified="2022-01-19" version="1">MNSLDGFAGYLFDERIHGPIHLPPYIIASLQSMLKDEEAHINASQLGVAQEASSQIEGRQWKVAKIRDLLSPIRRLPQECIEEIFFHYIRLREHKDRLGRQRLLRESQTEGLYDRVPPIVLLSNICSHWRNIVHSNPRLWTLLFPRTYSVTDKVPPAALMVEWLEHSRSLLVDVGICYSNRVSDDEWHAYCDLLVPISGRLRSLELPIELIIKGETVSERIRGLSFPQLEETRVTPSTRLCINSLLVTPHYFGNAFKTATRLSQLNFQGLLEVRQGSMQSYLDFPFPTSRLTKLTLICLSLGQSMLRDVIGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN05</accession>
    <name>A0A8H5FN05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_013371</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN05"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5342839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57847" checksum="3D0AFDC08515F06B" modified="2022-01-19" version="1">MVSLYFGPWKTLALVVLVTLAVRIFYKPKRNLPPGPKGLPVLGNVFQLPQALQFLRFAEWREEFGPIFSLNLAGQTMIVLNSHKVAADLLDRRSTIYSDRPRLIMALEILAGNMLFSLSGYGELWRKMRKAAHEGFNIRASEAYQPLQEKEAAVLVDNVLKDPNSWVDHLKRSAASTILTAVYGMESIKSKDDPLVARINDFVHRLTRASQPGAFLVEFLPIMKYLPEALAPWKKEGNEWYRKDTAMFQGFLDDAQRKVNAGQAKATFAAGLLERNSGQLGPIEASWLAGIMFGAGFETTASTLTVFILAMRLYPSVMKKAQAEIDAVVGRDRLPTFEDRDHLPYIQAIVKEVLRWRPPAPLGLPRRVMKDDLYEGYFIPKGSLVLGNIWAMNHDPTIFPDHDEFRPERFLDETGTINVVPADTRNQGHVSFGFGRRICIGLNFANQSLFIDIASLLWAASIEPAYDETGTEIVPSPTEHVDEGVVVHPAPFRCNIVPRSENVDGMLEVAKRKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPV7</accession>
    <name>A0A8H5FPV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPV7"/>
    <dbReference type="OrthoDB" id="2848852at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="711" mass="76959" checksum="8742E4ADC8B81700" modified="2022-01-19" version="1">MQDTRRHSFHFRSFPSRLHSRALVAKAVDILPRDDSPSSSSSSTDPNADNGRSHKLLVVGLILGFFGVIIIGVILYWTKRMNLVERRKYMERLDEPRPTTTSPSKRRGSPSKMEAERKEGLARNGSTSSTSSQPQTQNQRVPTRQKSLGRSLSTSTRHLLRSASTSSTNLLSSSSNLLRSASSSSTNLLRSKTFAKAKESNSLAAKITPFSLTDGNYGSHTNLPGQLDDHLREGTGGGDPGAIDGYGHGPRFIHTPGENMRIASRLENGVWMFSDPKRTRGGLLGNMGNESQVSLVSGGPHVRRHTADPFSVPATPIDTDGNERGSPFADPPLTSSSSLPRQPPTAARRPTLQKAYSSNNVLDVQQAQRVEDVSRSASPSGSIYSLYDYGDGGASSSSLAGPNGNSNANVSSSPRAPPPSSFPRNININTNLPSRPSSRSSMLSVSSYTHASHSPSNAYAHGIQGIHEPLSESIPRSKPRSVSVLLEMQREERERRSRHLSRGSLGGSSVLGVSLTGGVIHGTPYAYDGDKERWDGTTEGGWTEEPDEMSDFTHSDIHSYAYSQSAYSHSETHSHTQAQTQQGMEMSEAERERERERRLREDIERYRRGEGGAALKLDTQTPSTSTFTSALTPTSGSASAFSSVFTSNAYTPTTPYTPYIPYTPNTPYTPHTASTPTSASAVPTTSLIRKPSKARVPVSVSLDLGDPTNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPZ4</accession>
    <name>A0A8H5FPZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPZ4"/>
    <dbReference type="OrthoDB" id="3008370at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="890" mass="96809" checksum="72E2922981FB4F01" modified="2022-01-19" version="1">MHRPANMADENISPLPIRPRGSSTYSMGSVGTASNTSGQPSRRTSTTSLKKEKKELHNLAVLLALEKDDNRQLRQLVEDLRTELTRQGLRTEKAENELVEVTRKFMTMNQERLEALHEVTRLRGQLKLYEFHLNTAKAEIRRGQRFIDELNARRVEAEKLVSDTKNAKDRLSQELLAREWKDEGMKEGFIQGMERARAEAEAFLTMSDQLTEQAVLPDTGRRESSTMGGDGDSFYYRTDDETRRQSSTTDFTVFTRPETPVAHNPPSAPPPQDVAHPHDDDDDDDDPPPIPIPNPRPPTGDIRPIIIHNAPPSPRHPPVQIPPEGFIPITGASGDIVLPPSHELAPPPPIPSPGPSFVPLKDEAKLVPPPGALYTVNMMHSHPHPHPHPRSHPHPHPHPHPQSHSHSHRHHHPGSPESNSTTISQFEMVNVNDGFPKHSPMSAIPEVASERNSPIPSMNSSGAGAQDLHRNTSLRSQRSSPHPHPHSSHLTRAPSRQEDHRSHHSQSPHEHNLNRKSSLTSAASSSRRTKTPDKYGIYQRSTSPSQQGVSGGSISRGRTPSMPMPMTMPVASGGPAHTHGHGHAPSNILDDTTFINKTPKARTDELPEVSNFNPRRSDPLADTSFLTKTPRSRPDDLPDEYGGNNREPAPVIPTQAPSGPSSARPHMSAGIYTRPYPSSLQPDMGGGMFPSPSWHSEESSANYNVDIESPTPPQSEQFEENPREFREYLSASDAARPLPVSPRTQPSNMLHSVPMPGTPIATPGGIFIPTGPPSPSPGRRSSSPHPPSPNRPASPLGPRGMPGDFGYVGAIAGGPDESEPPVIPNVEELLRPHDSDEDSDAASSGFHSTRTLTTPPITVPTPNTGKGKGRGGGPGGASAGGARGGKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ08</accession>
    <name>A0A8H5FQ08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ08"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="19335" checksum="0981D843859FFE6F" modified="2022-01-19" version="1">MAPRPIKFDRFMGSRLRSDVSSHFCSRSRCLFDLFPQFHNASCWTDKFDFINQSLLLGSLTREEWNLDLKELWRVTKPGGHVQFFEPSSECWDCPVDLAPANVEGQLLPPPYSSMCTHLCPPSLSWSPVPMPIRYLTLTLTLAPIILLRSKHGIGFRFAPPSSSPGPSIGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQK6</accession>
    <name>A0A8H5FQK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQK6"/>
    <dbReference type="OrthoDB" id="3038673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14735" checksum="ED93F64C9D3D8027" modified="2022-01-19" version="1">MSTFRLPNEILDEVLQFCVVAEQKDDSKSDMPVVAEKGDIRWRLAAVCARWRRIVCDGMPKFWASIGIDNASLMDSEKAHVDPLLCMSLVRSGSHPLSVEHNLFAGSWFRGVMPAVDRKCMKVYGAYLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FS73</accession>
    <name>A0A8H5FS73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FS73"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="396" mass="43913" checksum="8923872CE05D4854" modified="2022-01-19" version="1">MLFKDLQQWKPEPLSPLQAFLFGHILRLRFPEEFESEEAPPEQQDPGLRESIAGGEKRRGDDDDDEDDDDERLDLRQSDEDIKTYGKQRVIGSGEESEEDEESGRETKRQKTSGSGTGQAMPYTRSYTTIASGVKEAEHQWWKQYIKKRPPMFPKHLSLDYIYKDPYAQKHESDDEVESGPSEVKDPNQNYDYSNSESDHERHDIQDTSANSQRGCANTDWNPNSSQGDISRDSGDNYDHDKAAASLVSVFNNLADDNGPILAGVDEDKDADKARKQAAVVQKRKRGRPRKPQTQVQPRPAENPAATAGTDGEVAQTAIAPSLTGITVAVVQNTVTPERRGPGRPRKLVTGVDMACPRHSSAIGGGGEVPDLPKRRGRPRKNPVAVPGELAMSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV64</accession>
    <name>A0A8H5FV64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV64"/>
    <dbReference type="OrthoDB" id="2864380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="213" mass="23369" checksum="6D313E11D054E8AE" modified="2022-01-19" version="1">MATGVAAISQLTGETSTNALATTNLKVKSLLDTGSPDFFSKPRLIRNIKVKIALEASFAAVADILATIQLSWTFHQSRTGTHRTDTLVEKLLAYTVTRGLFVTIAQILFIIMFVVDTERLTWTAFYYILTKIYVITMLAILNSRQSLRDTIGSHVTQDPNMDFAMRSAISRHFAEGAWSSSIPENSTTSFDEHQKANGSVLGLTPNQGPPVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWA9</accession>
    <name>A0A8H5FWA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWA9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="231" mass="25634" checksum="A3DEFEB5DAACD72A" modified="2022-01-19" version="1">MKKAAKRLFRRNPGTPRSSTPAPDIPNQSGLHTLADSALKTATNPTQNVSVTVSDDSSAKKGEVALDVIEKGLVILDVASEWFGPLKAVTGVLDECIKTYKEVIDNKEDLTKLMNDLTEEVQDLEKQRAENQSSEMKQIFEDLKIKLSTVLNETKQRQETSVLQQAIQSGRIAQEVQQFFKDITKAYANCKFKVLLIIARQTSEILKSLIFDKLKPSMKAFHDAQIGGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZE1</accession>
    <name>A0A8H5FZE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZE1"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="147" mass="16837" checksum="B7C9539A544D4208" modified="2022-01-19" version="1">MTDFDLESLVHLEETFYDDGYQGGFAHGRIHGLIEGRALGREKGYEMWEEIGFYEGFAMLWQSILLRDGKQEGRAFQHSKRLLNLISTFPLVNPSNVETSPAVGEDDAEMTTDIPKLFRQIRSKYKALCTTVNVRPKEFEPSPEPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G139</accession>
    <name>A0A8H5G139_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G139"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5356373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="41646" checksum="7CCA92C09D024537" modified="2022-01-19" version="1">MRKQVEDYVRTLQDQIVTSLEQLDPNAPSFKRDAWERPQGGSGQSCIFAMPATDRDGSASQNGSHQSLLEKAGVNISIVHGTLPPPAIKQMLADHSSLPLPEDVPGGLPFFAAGLSLVIHPRNPMAPTVHANYRYFEITESASSSAGDAESRDQPKVLAWWFGGGADLTPSYLFEEDAVHFHKTLKNAADSFGTQIYPAFKSWCDEYFTIPHRQETRGVGGIFFDDLNENPHPRLSEPSDGTTHSSAIPRSTVTVDRKRPKTKEELFSLIQALGNAFVPSYIPILEKRSKMEYSPHHRRWQLIRRGRYVEFNLVYDRGTKFGLMTPGGRVESILMSLPEVARWEYMSEMGQDEDSEEGKLVQVLKNPRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2P8</accession>
    <name>A0A8H5G2P8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_005832</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2P8"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="236"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5357289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="719" mass="81366" checksum="AC4016917FD474A1" modified="2022-01-19" version="1">MSLSQTPSSSSVNERKTSWTFQARNPVSLRLYKVLGTTFDDEATRESLATLSELYAKSVTAKGKETQRIDTEEDGDDETSAKVDGPFFVEGVPGESAARARKNLRRDMEMKLTEGSQHFLKVLSEVDEKLVALQTHVAAMRTSCDEAEKQLQLTDEASKSLLERAGNLREERQEVEVKKSIVSLFLSRFTLNEEETEAMVSRDVPVGKRFFDAMDKTERIREDCRVLMAGEEGPTKAGLDIMTSTSSHLEQSYEKIFRWCSHEFLQIGRDSQLEVSVTMREAVRRLRKRPELLTEALTSLSQTRQNTLQTSFLNALTRGGPSGLPRPIELHAHDPMRYIGDMLAWVHQAIAAEREFLEGLFGLKSDRRMVGSVRAFGEKPSEEEEWIRELMDLAVGRLCVPMKIRVQQTIKSQESSITSYRIVNLLQFYLHTMQNTIGKDAILSKALEELTEMAYKSFYDSIEAQCRGLLRAGLELDDSSVTPPIPILDHAQVLREIMSVYQSSILEDASTSDQIAGFRKIADVMVNPAVEMCIISAEEKKKVRHKWDMEVFVLNCLTYLLSVLEPFDFTSEAQKSIQGILDTRVEQLTDDHYHNIMVDAGLDEVATTCEKHDNSEPLSHIPSTEPSQLQIALGNFSQWLSGPEVVHSTRLSSLSLQRLHNKIHHTALTRMAKAYEMICEQVRRKENRYEAASTLLGSERPFGQVALLWQIFGLREDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3G1</accession>
    <name>A0A8H5G3G1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3G1"/>
    <dbReference type="OrthoDB" id="3353448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="95" mass="11213" checksum="A83C826CCCB9E6B7" modified="2022-01-19" version="1">MPMFSRTRRTHHYTTGTTSRRSRNPFHRRDRDRVAGGYKAALANPNSTHQGRKHAKHELRKMGRSTHVPLMTKIKRTLGIRSSPRRHTTTHRTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Y2</accession>
    <name>A0A8H5G5Y2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Y2"/>
    <dbReference type="OrthoDB" id="124582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="911" mass="101592" checksum="37F27B4DD7026DE9" modified="2022-01-19" version="1">MAVWTVVLDPNASASTMPPPELSTGATEPAETSDADISMEDSGPDFRARIISEIYKFRNHKKAAPKPLLTVDGIGQIDLPLTEAHACLIVEKAQQVRSGQDQDQDQEMVVDGDHFEIDGSNLNDEVLQRVTSGLGTQAGDTTIELDKLLLLKEGSSGHQIEGLVKPLGLFAAVIVFLPSEYTGGELVLTHETRSKALGKFSKESLKSVVVVAHFADARCEVKPLLSGYQLALSFNLIRSVDSPLGIPKSPDTALGVESARAVLSKWKNGRSEIKGAGDMIAYVFGHRYGKLEFWKGDKCLKDQDAHLVAHIRNVAENFGFLLCIANLHLDQIGTTNPEDEMVTQNNLSTLAMFDMDGTYIQGRMSIDFDALVPMDFFKNRTPDRQEYGERYKGDEGLEQHDPKYAPKFRADQAIRHLGISFSTSASSRPTPGEQELAHTASKYLQDLRPKRKRALTLLHCACLWKDIDLFDTTMKVLELRPTSDMSLLYEVWDAFGWDIVSARVEEKLPEMTELSMFETFLEKFVKHASDQETVLVSRWRERVVKLHISQFRRPRESEVPLLLREIEQHGIGWFMEEYLIKDYGGSVYDFWKKLVMGLLAKNLGNTTSSTSSAESHSATSAGAKTPFVQCLEVLVDLWDPTRAERVHYPSLFKYQEDRVFEIVELATQAKHLEVCTSLFTDILERQAPTAKTLTDFYQKLLPRLAQIKGLNMFSKPIDQFTNTVVSEYLTQVLGPKPAELKRVHSSFGCHHTDCQKVLEFLNATRKRSLKGRSLKLSRKPAIVQHLCKHLDELEPSDMVSYVVGSERAKRGNQMINITKNSILFTALDWRSKEEVTKMFLRQIAGGSDIVKTFLGTKCLGAVLKFLDGSGPTSMLEQSVAGPSNVANNSQPSIGGGLPTNPVAGSKRKTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G699</accession>
    <name>A0A8H5G699_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G699"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5358975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="33174" checksum="8F7B2490D6693644" modified="2022-01-19" version="1">MFKKRTRPESTKREVREEIEEPQQEEKSAEDNEEKLPLAELLELRKLRQSRLGIDSTKLGKGDAKKKRKRPAEEEGEKGGLRKGAVDDDEEDEKEKEAKARRVVRNNNFTQQTNALDVDKHMMAYIEENLKIRSKPREEEVKKPADPQEALYSIPERWKVESRKAAKEEGSVTSSLAMLTAIPEVDLGMDTRLKNIEETEKAKRVVAEERQERKKNNNDEEHLVASRFYRPNLKMKSDADIMRDAKLEAMGMSTQDDHPRRHHDKPQVATDELVMERFKKRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G820</accession>
    <name>A0A8H5G820_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G820"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5359905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="174" mass="19391" checksum="81513774AAD2E7CF" modified="2022-01-19" version="1">MGPFQIWHSHWEGMGCCDWIRPSWRVYIARDLPIRTKHKLHAIGGARGMWSLPIHQTLRGAGMPSTGEQDALILSTTIGAAPFFQKTAILHVTTGNIRVLEPDGTERQTIKDTESKKNPSQAAVPGAHTRACSISDPFIWMIREDDLIGLFIGEPEQVVSSPTILAFLTTWYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G876</accession>
    <name>A0A8H5G876_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_011326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G876"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="649"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5360138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1141" mass="121243" checksum="7074F447E656ADBE" modified="2022-01-19" version="1">MDCMAVPQVGSNGTNVRAQTVQYGNCLGGGSSVNTMVGSRPTLAGMNAVEALGNPGWGWDDFLPMMQRSETFTPPNAQQMALGASFNASVHGTSGPVGVSFPNPMLAPQVQNAAKNTTENIYGVTLTQDMGSGFSGGEFIELEQRRSSSAWSFLYPESQQRPNLTVLTQHTVNIITTTNSSNGGNITATGVTLIPTSGGDPLTFSVTREVIVSAGAPFSPGVLQRSGIGNATLKVRTREDIDLSKKAEAGNSFQDQILLNNISFPIADALKSNPNVTLNATMLGVVVAHATANNAFGNQGTQMIFSAIRNSNSVADQLVSSGSLVNAQSMALQVNVTANAYEIDHPLIELFFTPAGTLSIWTQTTLPMSRGTVRINTTNPLAFPVVDAQYLTVDADIQIMTRAARRLGLAASTPPFSNLLTDTAYAESGLPAVNASDDAWRTWALDRYSPGVHFVGSNSMMPQEMGGVVSPQLLVYGTSNLRVADASIMPLSVFPHCTLGLYGVAEKAADMILETASTTDPMPVPSPTSPSSSSSSSASASPTSPSGSTSNAATSINRNAAAAGIAGAVLVAFSLHIDSESSIGSDTGLICSILFPRLSTDLGFLCAVHELLDFERSMNLKIPGRQQAPGNKRPLLPALYTVTWLQWAQFASGLLAWTCDALDFYSVSLSVTAFSAKFDKNTHDITTAITLSLLLRTAGAIIFGILSDRYGRKWPMVANLLLVTVLEISTSFVNTYSQFLAVRSLFGIGMGGIWGLAAATALENLPVETRGLASGILQQGYALGCLLASILNLTLVPAKTEALGKDTWKTMFWLAGGLSFFTAAFRAVLPESALFIRARRDSEGRGISARARTEIFVREGRKMMKLHWGRFIYAFLLMAGELPNTYKYDWNTNLFVGFTFLAHGSQDLYPTFLRQTKGFSEHDSTMSTVIGFCGAIVGGTISGWISQYIGRRLTIMLYMILIGAFIPLWILPKSFAALTAGAFFMQFATQGSTGVIPIQLSEVSPPAFRASFPGIAYQLGSMVSSASAQIEATGGDNIRLPTTLPDGTTSSVPDYGTVQGILIGVVAAFLFIVTLLGPENHGNEFDKHRAAFEEGGGEDGAYLDNDTATPTSEGNLGSSKEGNDLEKDLVDEERIEEIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G882</accession>
    <name>A0A8H5G882_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_011332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G882"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="225"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="436"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="507"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5360179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="521" mass="57400" checksum="F5150B103617634D" modified="2022-01-19" version="1">MASNLAPQDLENLQLRAVRYALAHGLLYLPPGTQAAIPMSAIHAPIALFPTPFPRAQFERAKSLQSTYNTLYARIALDTWFLDEVMGTERGVGKVDDFVGKLWTGWKALRDEGLHQVRFIVSISDLCSHMVRPLHLGLFRSDYLLHVSEDNNVSIRQVEFNTISSSFGTLSQKVSEMHRHLCASTGFYESSPYLQALNLPPNNTIAGLVEGLAAAHTVYDVPSSQILFVVQPGERNVFDQLWLEYELLEKHSIKVIRLTLDELSSCSSVSSINAPLFITPLSTRGVIPIEISTIYFRAAYTPTDFPTPSHYTTRFTLEKSKAIKCPSIPLQLAGGKKVQQVLTQPGVLERFLSDEAHWGLGSSSPPEVISELRASWMGMWGLDVGGDDGVNRAREHAMNLVLKPQREGGGNNVYKEAVPAFLDSLPLEERQAWIAMELIAPPKGMKNYLIRAGGGESLVEMEVMSELGIFGWALFGDGVGESEGKVREKEVGWLVRTKGKDSNEGGVATGFSVLDSLVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8H1</accession>
    <name>A0A8H5G8H1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Multidrug resistance-associated ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_009126</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="934"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="124"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="510"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="799"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="17">
        <location>
            <begin position="2640"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="14">
        <location>
            <begin position="2792"/>
            <end position="3083"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="3156"/>
            <end position="3174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="3192"/>
            <end position="3233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5360312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3366" mass="374818" checksum="A8D7B76D4960273F" modified="2022-01-19" version="1">MERSSLKQMHHLWPLTPDRETKALSDNMERAFYERCPPEKRPRHLRNDTETPVSVPEDDGTTDDAGSKMDASDGKTPKEKPAVGSKPTSKSPDSAAQSPYDESLPKAIHQQFLVTWWTAGMLDFAAQILRTTTPQLNKVLLNWLITSYVWFQLSDEQREQAGIGKPRGIGYGIGLAFALFVMQESASLFYTYNQQVAMRIGMSVRAGVIGSIFRKSLRLSGRARAEHSVGEVMTMISTDCTRLDHFAQYGHHLWISPIQIIVALGLLIGNLGYSALVGIGVLILGTPIQGILVMIMFKQRQKAVAITDKRMRLTTEVLQGIRLLKFYGWEDFYISRITGLRQGELNAVRKSAFALAGIVGSMSLIPVLATILSFITYSLTGHDLNVAIIFTSLQFFNIIQTPLIILPMVLSSMTEMIVAVKRISSFLTAEDQPDPYLIDEQAKNAIVVDGDFSWDAVTGLGASTQEEDKEKKEAEEGKGKGSTKKKKDKNMDKGNADSVLPVTTPEEKEIKEEEKPAASIHSSQEEPFKMQNLSLAVPRNAFVAIVGRVGSGKSSILQALIGEMRRTRGQVVFGGSIAYVPQTPWIKNATVRENIVFGNEDNEARFREVIRACSLEHDLELLSQGENTEIGEKGINLSGGQKARVSLARAAYSSSDIVLLDDPLSAVDSYVGKEILENCLLSGPLVNRTRVLVTHALHFLDRTDYIYVVEDGAIKEHGTYRDLTRDSPLFARLMEEYGKKQSVNAKAAQKDDAVVKTQDLIAQKDDPLIQAEERLVGAVSWTTYKKYLRAAGGLSWAPAIFACLVLLQSSQVGNNLTLSYWTATSIRGFSQGDYMGLYVGFGAGQAIFAFLLTLIFVIVGIKASLSLFKAALWHVLRSPVSFFDTTPMGRFNTLSGISLRPGFTDRRGQVFLSTFASVLGTIGLVFYIFPLLGIIFAPLTVLYWIVSVYYRRSSVEVKRLDSLMRSVFYSSYSETLTGLSTIRAYRDQKRSITNAEAGLDLENRAYYMTITFQHWLTARLDLFANTVVLGIALFAAGFRDSVNPARTGVVLSYALNVTQIFGQMISSFAQNEQNFNAVERLVVYSELPSEDQVTLEPVKDLPMSWPSKGAITFKNVDLVYREGLPVVLKDCETWRKSKSSLLQALFRIVEIQKGSIEIDGLDIRSIDLDVLRNRLALVPQDSTMFLGTLRENLDPMATRTDAELISNMKRAWLLPNDGTTDPVAEAKFSLDSNVGDEGWPECKPEILDADTFFTGSNFSAGERQLLALCRALDEATSSVDVETDAKLQQTIQSEFADSTLLCIAHRLNTIAHYDRVLVMDAGKVAELGTVLELFDKEDSIFRSLCNEADLTREDILHHVLSLKNILRACNARGNSDDESMLSTLLTPLRAKFDLSPRTPNLPVPPPAENDDLSPEDFARDVLIELMRNSVSNLTEAETLKTRTEVLSEIHRIMLQDGRTKDVFRELDGLLVLMSALAAMGAPSAPGPIVEPAEQVLADTLECTRLAFMVLAEAISQHSENADYFKVSVGYDSLSSALAPLISDPKTAHETLGLLLSLSLNDFTLSNVFVTLKHADPTELDSKVSGYQTRLSTIVHAEAIHILWRYLPDATPTDSPVYYATLKLFDALTVRSHRNQAVLSTVDFVSALVDRFCEVKGDENKKRRSVVQKLLRRFLDMGATTAEAQRILQSAVRQDGTLDMEIMELIRGAMKSRWLDHFSMESLAMLSLTQDGMKGLPVTGFTFMMWLWIAKFPSEGTSHRIFAVRSGERDMVLLKLRHDGKLMFQTSGNSSPVIFSKLAFAKARWIHLTLVHYPGRDRASNPTIRLFIDGVLNDHVNWSYPKPISTSSSVQYMLGDDAKDTKLSWCIASSYFLSTPLADDLPRLIHHLGPRYFGNFQDPALVKFFTYEASTSLSMFLSTVAAASSGTSATTSMISKVLRDGLGISESSIVFALSPLNIVTSGSMITVPVNGSRAGALKEFSVKGDVYMVKVECLDAALWKIGGISVALRLIQVANTAHEVSRALSVLTDGLKNNWQNSEDMERLRGYEVLADILRTKTSLINMTSFETIFEFLGINFRSPDHSTITNVVAYKCLALDFELWSHTRLEIQRVHFEHFITLLETSRYKKFNTKQRIAKIGLVRRLLFVLQTDWYQGESLTFLMDAFKVAMNALWTKDETIKPIVSFLAANLQEDLSGSSSPKSIMSRIDHLGGREKAEKVFELLVATLSVPSQHTKFCAALPINRIILLLLGDRPSPLVAKQCLVLVRVSVGSTSSFIRKFEMISGWNVLKTVLPSCWDLEVNEAAFDLLLLAQGNDKGGDEVNIVCPQVVPIILSALHSGLNVVARNSSANGHVPTTFTTEATMESLVEKLMNLHARSGAFRHIFQSQQTTQLFVNAYKDFVAKISGQTAFNDYAVRILEKMAHLGLALALDNSVAGAQKRDILSTLQTAEQVLNPAAESTQIDPNLVADTRSVRQRFASARFSLQIGERTVMKIITRIIEWRKTIQVSERKRLRKNILDLRENRRQVSRLYEWTYRLTSERGLWYDNEPVQWRLDETEGPHRIRKKMEPVNPRITIQYVEGQQQPLRGVQIPDSEAASAIVQTEVPPWADSYEIASTEMEDRQLVEEITEDKHRKVRHELEPGDVIEAVQTVARISGVDSSPGLLIIGHTHLYMLDGLVEGEDGEVIDAHEAPKQLFFVPGSIVELDGPQRAQRWSHDQVATCSDKTFIFRDVALEIYFKDSRSLLIVFLDKNKRLDVHHRLTAITSRLAEVPTPGLLRTPLFGRVSAGARALSGLWNDELSTAQRRWQAREISNISGRTPSDATQYPVFRSYKASSDSWVLQDYQSQTLDLTDPKSYRDLTKPMGALTDARREAAEVRYSNLISVDEKPFHYGTHYSSSMIVCHFLIRMAPYTNMFKTLQGGDWDLPDRSLSDISRAYESAARDIRGDVRELIPEFFHCPEFLENYANLDFGVQQNTGEKIHDVKLPPWARDDPLLFVIMNRKALESEFVSEHLPAWIDHLSAITDELEREATIGIIHNFGQTPRKLFTTPHPQRYNHGLPTLPIGTLHGIEEDFQLLIQGSRCFSGSSTPVKQLALDMIGERIIPCPEGVLVVPSHPHEQIEWGARTGGELRVVVDQKVIQVIEGTLCTCAAFADANYLVTGSSDHIVRLWSLTRGYLSGPSLALTVSHHMRVHTDRVVSVAASRPWSIAVSGSDDGSAAIWDLNRAVYVRSIWHDTTGDKSAAVHLIDINESTGYIATCSKLKLCLHTINARPIATLDLTTMPSSTLYPPITALSFHEREYSHLGVLATGSSDGTITLRTWTADGTPEGTKAKWEFITMRTMKVRTSIGRGGRTPAVTALKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8K0</accession>
    <name>A0A8H5G8K0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8K0"/>
    <dbReference type="OrthoDB" id="2786563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="43558" checksum="F456DCEF0CD79519" modified="2022-01-19" version="1">MNELIDQILAYALSEKTNRPSWHTSSRDSPLLVSKTFHRIGLGHYYHSIHLSSQQQSLALLAILQSHPDYSPWIKHLSIDSIFESIADILSLCPQLVLLDLSLDAPSHVDLAPFCTALSTLTSLSSLTIRKPASVYLTQPRVRYVLSAVAECVSNGTWQNLREVDMPFKVSSDDSASLASPAALGGMLFPALPPPAPTLAPINPNLPAALPSPTSPTSPGPITFLSQGLSTLPNLRTFSTQLPTVWNEVLLTVSKNDKLEKIVLGSASAPVAPGSRRMSSGSAMPPRVGGVMLSGLYMSEAKKHPRLVDLIKAGTPILRNRSQTMAIRPGLAVSASMPCVTVGGSTSTSSSSASASASSSAGSAAKATATEGSGSASASAYSYPAAASTSASASASNNVETLTIPVSWRRRSSLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB62</accession>
    <name>A0A8H5GB62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB62"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84904" checksum="368A888C0C58D133" modified="2022-01-19" version="1">MRLLHTRTLELKEFFGKDIPLYAILSHTWEDNQEVTFQEFLYPTEEIKQKRGYTKIVKACRLSETYGFQYVWIDTCCINKDSSAELSEAINSMYQYYRNSVVCYAYLEDVWSDEDPRKEGSRFRCSKWFTRGWTLQELLAPSRLVFFAADWVDIGTKSSLEDIIQAETGIPSTVLHSLSKLQDISVAQKMSWAAKRATTREEDLAYCLMGIVGVNMPTLYGEGGARAFIRLQEEIIKRSADQSIFAWKAQNGEETSRGLLARSPAEFLSSGRVRASGGRDITTYSMTNRGLCIKLPLIPLDDQLAVCLEGQLEDRNLSFAIFDCQLEGRDQDQALGIFLERVSDANQFVRVKPDQIVLGHRWSTVSYLKQEIYVMEPDIVISQIVKPFRRSFWTVVTTSGNIRNVPRPDMLASPTGNANAVQTDDRSDYAIVETFPEFESIKWMSPLDIELEMKDAQKSSRESIISGLVLRGREIGMIKVQSTQHEESFVVVFGRNERIWADILTPEEWQLFRADSRQISMAQNVDRVGKSLKVTKRTSVSVALKKFHNSNQFLVEVDIREKMTIPYITTRLPPPLEYGFSVTIEADPELRVGIWATTFPADIWNPSKEKEAEVEAQPGLPSEVFLPIPSSREPGIVFFYDLTQSRKPLFAVMMGIRDFRALATFVYEMRLSSSDPDEWTSLCLRHWALATFDASAKSPLSPSLPASSSLSLDSLHPIRQVTINVKENTELDQYVTHRALIKINGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDJ8</accession>
    <name>A0A8H5GDJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDJ8"/>
    <dbReference type="OrthoDB" id="3063824at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="150" mass="16726" checksum="E04EBC1E34950BDD" modified="2022-01-19" version="1">MSVVYSPPVRPIVTHVDAPVALPGEDPPPPAVVDPGSAKPSTEQCERLILALPMDDGATNFRYGVVALPETYLVYGVAAAARVFDTYLVDPTPEHIILRQRIKNREDEWVWASIDPMNWKRLIKDNDQVGIFKNGVVLENFLHGEVFISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI82</accession>
    <name>A0A8H5GI82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI82"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21212" checksum="BBFF44BE4C6DA68E" modified="2022-01-19" version="1">MGRWTQYTEDTSRLPEGFKRVGYDADTERHIYEDRNGQTYYSAPGTEFGKLTRAPDCTDLFDERRPRLNLPKSESPISSFHDILPATLIASPTSAISTKSKTSTKSKTSPPATSTKQKQKADVQKYETMREVEVTKKPSRKFSMAVKSLGRSLTSATTRKSVKPAFELSEKEKANLLRSKTVAAPSVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ48</accession>
    <name>A0A8H5GJ48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ48"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="507" mass="53822" checksum="5A5D405A5F0B8870" modified="2022-01-19" version="1">MRMIMSLSPPSSHPHRLSPTNSMATATQANSAMDSTSTNDDASSWTTLKSVTLVLTCTLAMIVNLASSASVSVFLPVIGRDLGVREDSLQWTVSAFSLSSGCFLVFFGRLADLYGRKKAFLLGTSFLGAMSIGCGFAQNAVTLYILRGLQGLGPAAFLPACDLSRSAAFATFSAGAPIGGAIGTQFGALLAQNTRYTWRDPFFLFAALSFLCVLGGYLTIDKDEKSSDRMDKRVDWIGAFLVTAALALVIFTLGQGPIASHGWATPYIISLLVIGVVLLGLFVLWEHFLEQRPARYRAPLMKITLWSRDFVGLTPILTAIRMLPMTVTGIICNIVIVLLIGRVDVAIIIGLGSLFTSIGALLFALIHPTASYWAFGFPSTIVAVFGGDFVFAAGTLFVAKVCHENEQSLAGGLFQTLTQLGTAFGLAVSTIVHSSVTKNHASTGLSNAENAPLQAYQAAQWTAFGMALFCTLLAVVFLRGIGPVGLPPTDPPVQGEAPIEDAQKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLB7</accession>
    <name>A0A8H5GLB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLB7"/>
    <dbReference type="OrthoDB" id="7690434at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034537204" description="Mediator of RNA polymerase II transcription subunit 25" evidence="3">
        <location>
            <begin position="20"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="92354" checksum="670B0D1368421C87" modified="2022-01-19" version="1">MSTADTTLAIALVVDASLALVTSWPAVLQHYVSPLVRRIAETHPNCPYTIGFVTYGSSDSSSSPILCRNFFQESAVVVKAMREDPLKHFALGSTTAGGSKGLATLEGLVAGIEMFDTLLKSRDSKNLRSPVFHLIHLSASVADDSLHPQWNDLSELDETTWEKLPAELSNRDINFSSIVLHSKNARCTELHSSIPATKKVNPWFAVESTHSVLLSGFNITPSSKGSPLVVSLMFSVEHFSAGVKRAGEPATDKPPEKKPRQTPAPSPFLAPSPPAKPVIPPASEAPVLWTNTNVPVANFPPQLQGLFAEYRKHEENVKRIQAEYQAATSARQLDKIANIKTEMQKVMPNFQKYRHFVLQTAARFNQSSGSASQPSSNIPGQQRPPETVMHVNQGSSSQNSPPAGLKPGKSPNSANTDTSQRPLSSQTDGNSSSNPPNATDARNTTQLDPGQNFAASSSSGSNQDPTTQQSRMQMLAPDVAAQMHKLIEQSERSRVQQPFTTGAAAVSNANLAQMQSANQTFPQNAVPDVGPNVVTNANTVIGGPKPPVPASGPQQNPITKGPPVWQGVFFLPADPQTGRRELKVQVAMFTNSQQSVPAARPETWPPLMQLNSTRDPIVIGLDFQVWLKQRQALVCMVQPATGGNEANLANFRLLFEALQSSQRYAVAGWTTPSGASSPNALFFAHNNTTLAAICPITGITELPKQGLALKLAVNDSQRQTIMAAYATKAGGANPALMNANRPGMMPGQQYLGAMPGAPRPGVGPSQVGQPSQPSHPMSHNPAAMNALMGKLGNFGANGAMMANLGLQMNNFQNMMMNNLGRTAGGPSSVGLGGNGLPNISPEMMQSFMQRNAEGNANNGGGQGPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN35</accession>
    <name>A0A8H5GN35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN35"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_625, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="36656" checksum="8937150BC645FC14" modified="2022-01-19" version="1">MVSGSDDKTIRIWDANNRNIVCQPLRGHTNFISSVAVSFDGTRIASGSHDKTVRIWSAISGEAIGQPFQGHEDTINTVTFSPNGTRLASGSDDKTVRIWDILTGDTIGKPFQLNGIIWSVSFSPDGARIAAASDDVTIWDANNGDVCWQIKDGGYALNFSPDGTRIVSGSDDLTVRIWDANTGAAIGQPYQGHQDQFSSVVFSPDGSKIISGSDDQTVRIWDSSVQSVIHEPGQGHQGGVYCVAFSPDGARIVSGSDDRTIRIWDTSTGNAIGQPLLGHTDEVYSVAFSPDGTRIVSGSYDGIVRIWDTSNGNVIGQPLLGHTRRLSVIVIRNESDKLCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRP5</accession>
    <name>A0A8H5GRP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRP5"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5369776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18504" checksum="4659E4CF77849F0A" modified="2022-01-19" version="1">MDIEIQGIPQSLRPQYQARLRSAKGELARYKKMSKDLHASLARSSLLGSSSSRSAYPSSDEPYGDRSRLLAGNALLEDGTKRLQDSQRLALETENQGADILMNLRQQREQIENSRSTLEVANNSISRASNTLSSMIRRMYQQRAVTGAIIAILVLLIIIVVWSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSD7</accession>
    <name>A0A8H5GSD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSD7"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="72799" checksum="D6F6997CFB1A19AA" modified="2022-01-19" version="1">MPKEPSMSLLFHPKKNAKNTIRRPNPTSNPNPTPSSSPRKSKAQSPMRVDNDEDEDTMKLPDTTFTEYKVMSSALNGWKYDVMKFDSRKSVDVSRWETPVKLNRKDLRREDPAASGVGQAVRPMLGADGQEVYGADGRPVMVDAEGRPVTDPSGSGAKGKGGLANSKKKFQKKTRQVFTVSEEVRLLRREEKYPWVMEDASGQELWTAQLEDLGKAGIHAFFMPAANDVFKFVPSHRWYKFQKKLKHDLPTDSVTVEAAYQKNQKRDPSTWLHQRNGKGPSTATAAMFKAEAEGRTISLGSGSLVHNASQSYGPGGRRLRAVDSGGDLFGDDEDGDSKPRKRELGEEGDLDEVEYEEEFADDDEKMEINEDEETKELEERLKKEYKNANKTREGYIDESEEEDDKPMSKQERAMQKMLKTREGIDAYESDEDENPYASSAEEEEEEPAPVSNEPAVLQQKSPTPTSEFADIKPSVPPTRPPNVGDNVSPAPSPVPGLGGHSVVAKRATSPKAPKLKSNNVSRASSPLASGSRATSPIATSPVAQNGLQKKRKAEESPTSPTSPNGVGHPKQKKRKPQPTGVTVATPTGPLEDRLLIEWLKNTPNASTRECIQYFTPYLTDEEKKTKFTALVKEVATLKNGVLVLRNAYRGGSSAPSPAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTK0</accession>
    <name>A0A8H5GTK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTK0"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="35957" checksum="01E0CA057F35B646" modified="2022-01-19" version="1">MTAVAAWSQDLTAGKTVTITPPADIKITNIALGSEIADKDGRTTVKMTYPKLPAPDDEDEEGVETVTATIGSLTPGKIEHLTTDLFLFEDTIYQFELVGKNTICLAGYYVDQNADQPPGGFGEFGSDMDSEDEHDLRFVSSDVEIDPDELDDTDTSRFEEVEEGEKAKAEKPQSKKRPRDSAGEDGKPATKAEKKSKKQKTEKAEGEAKKEKGEKKKEQEGAEKQLAGGLKIKDSKVGTGPMAKKGQDISMRYIGKLQNGKTFDSNTKGKPFKFRLGAGEVIKGWDEGIVGMQAGGERVLTVPPAMGYGKRGSGPIPSNATLIFEVKCIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU78</accession>
    <name>A0A8H5GU78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU78"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5371158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="560" mass="63043" checksum="1C4D536E203CDA17" modified="2022-01-19" version="1">MLRLLASAGTRRAVNSLAGPARLPAASVLRAHPTTYSTEAPLSTPKTAPTATTPNGFKVTSEVPPPSDIGNGTGEAGTDWSKSYQGLSQEAFPKEIADILMAPIDPMDIEMKPDGLIYLPEIKYRRILNRAFGPGGWGLAPRSETNVGPKVVSREYALVCLGRLVAIARGEQEYFDPTGIPTATESVKSNALMRCCKDLGIASELWDPRFIRQFKSKYCVEVFAEHIPTKKKTKMPLPLEPALEFQVDTSTTEIFFPPDNTSIPRGQHRSKSFQDSRNPSALMHRLINARNDGTHLSISRVEYMQRRIKPFHEFVVVVFRRGGSGGFGHRDSSEGPQRRENFAVLERNLSDTFVERSTPFSWKKRFAEDIMHVSCTGDYRDLEELMPGGWIKLAELQVDGAEHTDRFTMGQLAVLTAVLQSRVPYYRLCDSQCYYYARMIWQVVNMAVGSNVQVAGGQRRQNVFGRMMDRMKAEVIRGAPEVKSAFEERWDDFVEEVARHREEHQRYYRNAIADAARARTMRDEAVIQRDEAIALMKSLEDEKARLAEQLNQSQSVWGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU85</accession>
    <name>A0A8H5GU85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU85"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="53453" checksum="9B437087B64EEB2D" modified="2022-01-19" version="1">MTLSSPLSTSQANRKRKLSVSDHEQDPILKRRNAKGNPSLRVEIPTASQLQESAYSDVESGVSGADSLFDDIFDDISFEVGEDIVTTSTATTGLNTSLDSSRPIQLPSISPGALPPSLIPSAPAVRSLRSLSSRPSRPSQPHHDPNGTPSDTPSSPKEFPIPGLFFNPSILIPQELASEVVEFCMKTYFSGRNANVNQVMLFGRSPTSSSTPAVPASRPSPSSTKLKENEDDDTDSQGYSGLPPILQTLLSHISTLLLPHLPPTVHSLYFPTAAATATSAPATCSSLSPPLTTTRTTRTIPPTSSTQSTPSPNLNRARQAIINLYHPGEGITPHVDLLRRFGDGIVGVSFGSGCVMEFRRVGDHPHDGLGDSEISESYAVPSGAGSSRGSNGSSDGLDDAYDLYLPERSVLAMSGDARYKWTHGIPRRKWDCVEEDGEGGVDNVVVGVDTGGCPGDGELLKDTNDDSGSGGRSSRGTWLERGTRLSITFRFLLPGAEIVGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUZ4</accession>
    <name>A0A8H5GUZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUZ4"/>
    <dbReference type="OrthoDB" id="2745898at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="46145" checksum="D9D3569F975382CF" modified="2022-01-19" version="1">MSAGPPELIDSIIDCLHNSPRVLKTCTLVARSWLPRSRVHLFRRLHLHFEESSRKPSLNTYLANFRSYILSNPTIISCVEDLSLDLRVRPSPPSPNDIMDTVPENLPFTNLKSLDIGKPLYAPTPDASKWRASRILTLIKQNPGLQKLVVFGCDLGRSDEPEAQDEAELLAYIVTSMPGLQSLRICEFDVPFASIESERSLLPTPSNPSGHLVSLQTLAIEHCQFGLGQRLFPRTGDLYRLPELVSLVLLDCNRPDDEGNFQLVNQYPRTIKHLVIALSEMNTEVTNASWAEMSNLTDLVLYWSTPEQLITLLQHFLEIDTVKLQFLRLNQLFLQSRAALALLDAVLAAFISQTPSLQRKVAVLPKVNQHNDEFRGLDLTDVFAVFPIAAQSGMVEMATETDDLHDMVDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWB1</accession>
    <name>A0A8H5GWB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWB1"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="6">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="174" mass="20702" checksum="A30705BC2065D4D7" modified="2022-01-19" version="1">MTSKFDPQNAQNLIEIEKQFAVKAVEHAQTYWNLLEKVPPKELRLTKLDDEIYQHTMETFPELAEPPHDKLIKLDEEWMKSPEGKERWRKFITEYEKKVKDHNFGSLIRTDAREEYGERNTIFVTRIQFYAIEIARNRLGLNDKAHEIAKVEAEKEKAQKEKDAEEANKKKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY02</accession>
    <name>A0A8H5GY02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY02"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="118" mass="13182" checksum="2FFC2C576893EA84" modified="2022-01-19" version="1">MYVVKFSTTAHRHIFNLKDSSTSQASRMSSNSPISIVHIRNLSTEFRFLHWHWEVPTGRILSALIITFAIFGFFQVLGLVLEIFKPQKALSSEAPEERQLGVPSANTTIGKGGDHEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYU5</accession>
    <name>A0A8H5GYU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYU5"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="123" mass="13368" checksum="E3EC2F49A7BFD4CA" modified="2022-01-19" version="1">MAASADRSKPYIPQAGLANDGWSKEDEATATCFCGAVQLAFPTQGPGLVNVHVCNCTDCRKITASMFASNFTVDDKYLKHIRGQDNLKTFGQAQSIGSHKKMTNYFCSTCGTLMYRVGESWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ79</accession>
    <name>A0A8H5GZ79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ79"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="736"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="908"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="965"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="980"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5373709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1207" mass="129199" checksum="7749CA38A60A9D64" modified="2022-01-19" version="1">MSQDSTPATSRPGSPVTPLPNQTQYRFNWDRKGPESVSGTTTGPNDYFANAPPRLAHLFGGSTISLTIPALPNEWSSASQGFHAISTVLNNPHRKQAPPKAHSALPAVPPADLPRVRRKDFDSYLRAISADWEKLRQLHPSTSSSSEAELEIPPPPLASLDQVPRVFFNSDFDLSSAATFAEVTEANEADLLDPTALGHALPLLEKFSHYADTIEVHLAHEIALRSHSFFAALTNLNLLQSESTQCLSQISRLRGMLEEVDTGVAKRGLEIVKLEKKLTNLKAVESNVEGVKDVVGVTSQGRDYIGRKSWNEALGVVQKLEGMWEPSTAPPVNDQTIPEEDENEETSQAGRRLSVPLSSLYAFSALPNHLQSLTMEIATALSDELVEVLREDLSRRIDEGNKNRNSHKMKDRLTPLLEGLLQTQGLKEATLSWREVVLGEIRGVIQKQFPEFQLDEDGARTPIEADRPGLGAHLRSLSHHDFMTSLRTIYQSYLNAAEGLQAQVAIVGEVVECAEKLKTIASSSSPTTTTTTSSLTLVHTELQDTLTSSTELAHVLLSSLISSRSPSHSALPLASFVEVFATTWDFVISSEVICKKMIVALRGSVVSQARAWLKTFHDSKMAESAKGVESELWAPQDVNRGPWTNADTTMEVQRAVNVMVSSAMGDPAELGIAWLQQANKKEEATDASSSPQPQPNGKDAFSVPGPPGTPTKSSSPAPSSSSSSSAKSKHLMIEGQPFFTVKATSSVLLLLLEYLRIPVCLGLLTADAMQRVIEFLKAFNSRTCQVVLGAGAMRSAGLKNITAKHLALASQSLSIMIALIPYVRETFRRHLNPKQAVMLVEFDKLKRVFAAINHRLAEAYGKIELPHSEAKMRLLADARYLHQKLSSLKGVGGPNTMLETVVLEKSIPKPAGAQSPSPSPMPTPTRNNTVASPPTSAISNSNTTQRLKGLLSGRSLTFDKALPTPMSARSATLPPPPSSTVPKTASALSNGTSAGTVTSGAALNRSSESDGASGGSVSQHKSNGNASPLPPLPVEENANQKPALPRSGSSGFRQVEILPDSEAESKSPTVPQKDAAGKESYANSEPERPVDSSVTDRKTTTRGTGTVSTASPSQDQEKGQEDSQGLSRPADSSTAQPTPPTESDAVINVNPGLTESPKTSVANLPPLTLSESRSGTAVAAPESDGDGAIPATSTATEQSLNPDHPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H005</accession>
    <name>A0A8H5H005_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H005"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="487" mass="53275" checksum="A16F6910A9E9B632" modified="2022-01-19" version="1">MGNSSSLNTTVTSRDHVPPPFPKAKGQSLSYWLQGVRANPLLDHMTTEDVPKEAEVVIIGSGMTGALTAFTLLSSSNPPSSIVMFEARELCSGATGRNAGHCKPDQWRGYSKYKSMVGKEQALKILANEQETFEKLVSYVKEEGIDCDLWVGQTLDVAMTEEIATRCAENYTQLEADGGNVSKVEWIKDRDEARKRSRVPNAVSVFSWEAGSFYPWKVVAHMIKKCLAYGNDKFNLQTWTTVKSVTKSTPDSAKEGNEEKWIVETDRGSTIAKTVVFASNAYTAALLPEFTGVVVPHPHMCTKLIPPPAFSGSKALQNTYGVLVPNNALFSINPRSSTDGIVLFGGSNPGQGELIKWVKEHPEDRVNDGLSGFKPVSDAVREWVGKEWKESGLDLNAGPGQGVDYQWSGIIGFTSDGLPLIGPIPNKSGLWMCAGHNGHGMARIFTAAPGLVHLMQGGTWEETNLPECFELTEERLERMRGMEVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H174</accession>
    <name>A0A8H5H174_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_000211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H174"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="13 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="48"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5374833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="436" mass="47637" checksum="15C27C12CF250D61" modified="2022-01-19" version="1">MIRIAVCKAALPNLASFSSALPRSLPRTALSLNLFARRGYAEAYNRTKPHMNIGTIGHVDHGKTTLTAAITKVLAESGGATFTGYDQIDKAPEEKARGITINSATSSTKLLRVTMVTLTVLDMLINMITGAAQMDGAIIVVSATDGQMPQTREHLLLARQVGIKKLVVFINKVDMISDPEMLELVDMEIRDLLSTYNFDGENTPIVMGSALAALDGRNDDIGSTKIKELVKACDEWLELPQRDLEKPFLLAVEDVFSISGRGTVATGRVERGTALKGTEVEILGLGDSIKTTLTGIEMFHKELDRAEAGDNMGALLRGVKREQIRRGQVIIEPGSMKAHKKFRAQVYILTKDEGGRYTPFMQGYRPQLFLRTADVTVTLNFAEGTPDAAEKMAMPGDNVELDCELYFDLALEVGSRFTLREANRTIGTGVVTKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1D8</accession>
    <name>A0A8H5H1D8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1D8"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5374830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="734" mass="80526" checksum="A41357540ACF15C2" modified="2022-01-19" version="1">MVMEKLPQDGTYGIPPGFVNAQYRFIMNPSGDYTVHFADPDIFFQWHDILQVIIPRTEGTGHTTCPICLSPPTAPRMTKCGHVFCYPCILHYLHTSENKWARCPICFDSVNERQLKNVKWFDGPQSSSSPSSSSTSQSPSVSSPAPGTLLPMRLIQRPAGTTLALPRSSTYPSTLFPTSIPSTSASTGIIAPPFYFLPDVYTFARFMLATPSQFISDLSDELADLEVEKRVLAGMRDEAGIAFVDGAVRRILGMIGRVKGEQIGVSLSGEAGNWDLVQERIERVKKELAIVEDRAEKEKEWADRIKRAEEEKERERVDEVDPKGAEQGEQEVPEEFLAIKSGGAFTNGSLTLSNAPSPSKSTRNSDSIPRHPSNPHSSSAAPQTYYYYQAASGLPIYLHPLDIKILLTQFGNPVSHPGHPSQDSPDSRSSEQSKPNGSKRNPKPKPNTGRGRSHHNNYYSSSSGGGPAATGDYSALPDTILVKVDAFSEGTIDEDLRKRCKYLAHLPEGADVCFVEVDWELQSSSTSRSIPESESESLTTILPATLQPFSHALSTRRSRRREKGRKDERARVKAEEKEWEREWERTRLNGLGVARGTSLPNGHLQSRVEEFADGMGEVNVEVEQSQSEPQSHSTPVSAQSPPASGVWGSRSFASAAQSPASATPSRRAQTRQTEREREDEWEMDIAWHELEQNLHNGRGGSVKTGGKKGKGGGGRNKNTMVVLGGGGPGGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1L4</accession>
    <name>A0A8H5H1L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1L4"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5375124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39428" checksum="CEB4BBCC6C1204CF" modified="2022-01-19" version="1">MANWSTPSAHQFSLLNQFASSSNHNSTMRSQKRRLDSEDGSENSQEHMDRSPTPDRPKRAIVKRARTSPTSSEMSLRDDRRPKDERSSTSEQDVDIGVLLARLPPHSLLPILTNLVEKHPSLKNEVLLLIPPPTLETAVQELVAAGRKLRDAYPHSNATQPNPLGFGFAFGSASSSLHSTMSGPHHSTGMRDEYILSRIRPVLAEFVSAFSTYMPYFSYVQNHATHSMQSQTSRPQSHLTEAFRFLSVVVEQISSQPLLVQSALESDLRDRLTVEWNGWMHKLDTIVNNEGGMFGSDTATGWIRHIEQYAVTDRQSPWITTLYKNLRGIFVMKVGWLAQRQPVYRMEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1Y8</accession>
    <name>A0A8H5H1Y8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1Y8"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223636" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="33"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="423" mass="47757" checksum="4728410C5F2697BB" modified="2022-01-19" version="1">MRYLLASVFLLLSNFWLYDASSLVAASRTPPGFVTTQGTSFELDGKPFAFVGANSYWLPLLTSKEDVRATFREMQAAGIRVLRTWGFNAINGSELAGALETDLTYYQVWNSSEWVLNDGPQGLERLDFVIQAAAEFDIKVIVAFTNNWRVPGAELYINWIAGAGVTHDVFFSDPRIIASYQRYVKTIVNRYKNSPTIFAWELMNEARCLGDLPSGPNCVPGTELLTKWYKQQSDFVRRLDPHHLITTGGEGHFFWRNATGEFATDYNFNGQAGEDFDADLTLDNIDFATYHLYPQVWYSNLDFPGSNFSLEQWGLDWITLHAESGARAGKPVILEEFGMQGIENKTSIYPSWVNHAIETKTAIMPWQFGVLGLKEHGGNHLFKYEDRLINGASPNDGLAYYKNQTQLWNIFTHAASLLSSHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIT8</accession>
    <name>A0A8H5LIT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIT8"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="486" mass="53412" checksum="8AB7144D7BBC5BC9" modified="2022-01-19" version="1">MDSSVTVSLLPVQLSLIHIPRSRLRQLTTPVIHQILQNSPTFLNLTCNELELTIFAEAGTIDEFHAIARRDQLKQRARSGSGSSRKSLSDSRSFEPIEISDENWSVLQIDSHSDPVDNSGARVNELSAPLAAAGISILYQSSYMSDFIFVKRSRLGEVMALFEAAGFDFYSTDSTSPPVLTRSRTSSTHSSVDSVRDKSHSPSSGDVCILSPDLTCVGLEDDNVDHWSLKIIKLVAFPDLIPIPGHSSPSIFSPSSSTDSFSNSEEDESLSQSMSSLSSADQPDAPLPKPISNHFTIPGPLSPLSPITAPEPHPLSDEPQSYSNATSCTLRVPFFSLTRTAEGSSLTTDAELLAALFPPSDRYMIICGNELEAADRRIARARQKKRERWALERIEEENGCSNGIDPSEEEESTGSDQEDESEDTTLRCLQIDLRKFGLDKHGLVNRFSRVLDENCINHMYSSSYKTANLLVGKKHALRAQHLLKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIV7</accession>
    <name>A0A8H5LIV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIV7"/>
    <dbReference type="OrthoDB" id="2611327at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF12">
        <property type="entry name" value="AIG1-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="108"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5358822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="602" mass="67240" checksum="269777A2B78914CB" modified="2022-01-19" version="1">MHFKMATPTQDIDMNLAPPEDTSEFLLIDKPAVADPPVGSQAQTTLNPEDVSTPGPALTDVRTEPQDHLTTSDPASVAPMDMSPVLNDILALSKGVVRTDRNKEKVFTILLVGETGVGKTSVLSLLFNVLSGNRTENYMDFHDQGNEVEGSQRHSQTGSARLYEHTSVNGVTLRILDTPGLADTRGIQRDEMHKKSIAEAIQRSIVTVNAVLILANGTVPRLTVGTDYALSTLSSIFPRSLANNIGFLFTNVSSPLSWNFDPSALPLALQNNALFLLNNPIAMQKKYYQFVENPYTSAKLKSQFRRSVLSSEEEALNTLVEFFDWLDGLEPQPTFQILSLYDQSQHIETEIQNTLAVMHQAAQADKKLDEVQRKLEGAEMDMKTYEAYEAVINRKEWQQIPTSRHNTVCCVPDCYSNCHVPCNLDFTLDPEQLRGCTSMYESGGSHCCVCPHERKDHRHYNSIWELKEISEKRTNEDAKAKFERARDEKGGAEEMKKEIEEAQVDLQNLVQNATDDLGRLVERYSNLALSGSFTGQVEKAVGVLEQNLESMREKGAGAETIKKVEESLDQMRRKLEVLKKAKGRDVSFVQKAVTIARRLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL18</accession>
    <name>A0A8H5LL18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL18"/>
    <dbReference type="OrthoDB" id="3265815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="355" mass="39739" checksum="F7C7D4FF2110C177" modified="2022-01-19" version="1">MDYNSNPHLPAPNPDDYHFEDWIHTAHISNDPFGVNAFSGYSTNIDFASDLNTSSAMESFSRPPLFRRLSAENSGEAIQSLTISTAFQESPDDLDRPTPDTILISSDSVAFHVAQASLLNASDNSFGGLLPITSEYKIERVRYLPKVQSSELNVMLHIIYATNWAHFCPSLQVIIRAIDHLPKYGIAPNTWITTTNPIYDLLLLYVPIYPLDIYSLCGRHDIYELATAVSPHLLSFDLSSLTGEDAESIGSLYLTRLFRLHRSRVEALVDSLMPAPNLHNPTQDCGYESQKTLLSAWTMAVTYLSRCAKPDITTGDIRNVFDSMTTQITCKDCLKGRDDRVNKIVLNWTLTKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMG4</accession>
    <name>A0A8H5LMG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMG4"/>
    <dbReference type="OrthoDB" id="3045818at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="446" mass="50900" checksum="DB305BB2E726CAFF" modified="2022-01-19" version="1">MLRSTTRLRQPVSQCVSRSNSLQRTVLSNLTRFHPAFSSLSSSRSKLKEKQRWSVGLHTGRSLRNEHTKPPIKAGFCPPYMDYEEAVAIIERANSVWPAPPARIPIPEGWSCTWDEWPYLFGFYWLSPEYLMLPYIERMVNIKYALPGDARPILFYNAPTQSENGQKTETDRDTEREVVPAWDIFIFTIVERPNEFYLHTEGTLYRFTNPSLTETELVSLLATDPTLSSPSSPLKYEPVPESEEGLKILERIETRDQSVIPDAAKFLGYTPEHTEPSLENLYAPEELETSEDGEPSDEQLEELKRLTRELESRSPEFKEASEVWDKELKGEGGVQSPGISEEDAAGLEALAAMTGLSSDLQQVENMMREAEGDLQKLRDVAKKGKDNTELTEEEIAQLAQQIKQGKLESEDIEEANYKRLSDTLEVNEIDSDRVRVRYTPKEDSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMG5</accession>
    <name>A0A8H5LMG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMG5"/>
    <dbReference type="OrthoDB" id="2536714at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="810" mass="89181" checksum="575765CC05B52F14" modified="2022-01-19" version="1">MDTERISQRKATFSIAPNPPSPTDSLLPLTNSASNSSTSPPPPSTPPPRYHSRPRYPNDLGRVPLHRRGTSQRYEPFEDLLREAGYKETRVFTPESERTAGSSHDDAALSEAKDQRSSGRAVGAVVDFLSGLIPGPTLKRSTSLRQSFTTAVDEVPRSDVPSTPTLARHQPSSPSLLSPRQSSRRHVQRPLDPNQSSISSLEDLDAPAPKAQDHRGKVPPTRPRPTSHVAEHNLPYSHNNTSYTSLNHYSHRYHHGPLHSHSNGGSQPQSHTLYRNTSSASTTRRNSNRSPAVQPLSPLPQSSYESRQITHTIYRPVPSRATAYLRHMASVPNMPRPSSTPAHQSLLHAQQQQNRGMFRTQSRDDDDDEELFSPLTRGDGEAETDAPPPLPRTWLETVARAVLSGGAGAFAGGPASSSMLQRSASNPPGHHARLSPALRQTRSVISRTQVHESERDTKLPRSRSGLSDHTNRGPPYMGERSIKSAAPATSRDAVQPELLSRIGRSTTSEGGVRKTRVVCRSAPTSRASSPVKNRKVDRSERKGMGSGNAVDYDDNVTTDRGRKDKKGLQRVTVPTLARTRVEGDDVWHRKVPRDKKAKRSKVDDGNRYLNEWNWDGGNGNESDVSYSASEDEDEDDEEDGELDLARMLVPPKRQNSIHSLRKHLISTHNNGVVAGESGITGRGSSSGLTRRGSTSVYDSGNSRIFRRWFVGNRMSEYWEDPDEGESESSGSSWFAGATMADLQRRLVAEHEALERFLSDDAGAGGRESHGQQLNRAEAYRSFEGPRSSRNGTRRGLPNLWIDTAQSATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQH4</accession>
    <name>A0A8H5LQH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQH4"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF85">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5365646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="265" mass="30022" checksum="4736EF0E6A496E7F" modified="2022-01-19" version="1">MASYVPNKIDLKPRRHHGYAVVLFILGTLLPPLAVAARFGIGKDFWLNCLLTLCGYIPGHGHNFYIQNIRNNKNHARTPKWAQRYGLVDTSEIPTQGTEVPMGESTLEDQPYEEGQNSSLSLSSDDHDARPRQQGDALWRPEDEQFYGNNQAAASRSSGRWHYPANFDDAVVSSSGSKRGKKKKEKKDRWARTEDAYSLSEQQQRKKAKKKKSRASMSTVSRDESTEFPEDPEGGLYGDRQNGNVDAQRENQRSQTTDDVFSHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQJ0</accession>
    <name>A0A8H5LQJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQJ0"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="40603" checksum="690CEA22249472EF" modified="2022-01-19" version="1">MRDRSDNYSVVLLPSPTPLFHLVLAFKMSSGSSYSFMNGHHIPNGSIPHSSPTPDMQSAQHPDFASAYHANGYPPNIYQDHDQKIVHHLYENGFKQGEYADILLHVHQNVYRLHAIILSRSPFLVHLMSTSPQVNGLKAIYVALDREPDITLEGFYIALGYLYSSHSLHAIQPHNARAVLAAGCLLGGMEELCEYAYETYKRSISVDSINSWLEFIDRIPAPSNGNATPEVSSVSVFGFYAQRIRDDVFHFLVVTLPEILELHNAPVDGPPSSPEPNGREVLLQVFSRVPFEMFKAAVESPSFQIGSDQARFKFAKEAIEARKRGIARGSGCEETVVLAFGGGNTGGSAVHVTRKTRKRPLWKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQL8</accession>
    <name>A0A8H5LQL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQL8"/>
    <dbReference type="OrthoDB" id="2798516at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="201"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="457" mass="50472" checksum="9E95E36F582A241F" modified="2022-01-19" version="1">MSSTLLSTQAPTIDNTLGAVFLGAVLASILYGITTLQVWLYYHRYFHDSVLHQVSVGALWALDTLHQALIIHTAYVGSLKAPGSPKILWYFLFLSLSTPAWSLMYLFIRTQVDKASSCHQRHHHSHSAKFVCIPSLDTDRLNGLRFTHPVSGIHHGYLGYLVALVVGAGFGVVFSYEVFTASTFVTLQNVTWSINASLAASTTIDFTIGLAMCYYLRKSKEVVVFQEGLNSKLTTVMQYMLTSGLLTSAISLSTLFTYNLMPDNLVFLGLQFMLTKFYTGSFLAMLNARQYARSNSTSDSQTHSQLGSRLNSTTRSQLSNVQLHVQTSVHTHLDHSYSSLNDHLKFNGVSGFGGKNVNGPGQELELTSPSSMTSFSPGSSKYPSDIGTLTYVSYDDRSGAAWKKDSKWDDVESEAGIGIESPASAVVRPALAYDDHPYISPANRNRERSRPDYAHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQS9</accession>
    <name>A0A8H5LQS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQS9"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="155"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="67627" checksum="EC1FC9906DE5B8AE" modified="2022-01-19" version="1">MGNSQSSTSYNRREIRRLRSAPALPRFSLGCSGRHSQSSVSSDPSSVLDLANEKSRYHVDVYEVQHSDNSSEHQPQPFSPPFTPSSDNTRTFSQSTHSHQRNLSVYMPGQDVILPEALDAYNRFLQGFPQYRLTWILDSLRRSDYGRLERAKETYVDYMGGSLYPESLVRVHTDFLYESIMGNTHSVSNSSKLSLKCADEARAAVLAFFKATSDYTVVFTPNATAALKLVGESYPFTDQSHYIVCSDSHNSVHGIRQFAINHRASVCYIPSTNHGGFDEDIAKSLLLRHRRSKNLPASLFAVTGQSNITNSKAPFSVIEYAKSLGYHTLLDAAALAPTSSFSLSETPVDAMAISFYKMFGFPTGVGALIVRKSFLNELRRPWFAGGTVEVVQVPGNIVTRSQEPHEQFEDGTINYLTLPAVTDGLRFLSAYLPFLPLRLSCLVYHMATSLSKMRHDVTGIPVVRILSRAPSKPLTSVGELSETGSTVSLIFFDSSGHMIPNSFIEYAATKQNISLRTGCMCNPGGAAAILGIQEDMKKLYPGVTLKDFEHAVGRELGVVRISLGLGSNFQDVWNVLRFVELLKDGVWRAGMWNEWVINCGESTFESVGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQU6</accession>
    <name>A0A8H5LQU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQU6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="10637" checksum="3CBDD85EC11B04F3" modified="2022-01-19" version="1">MPAQHHYSAFPSPSTSLPFAVLSCIETLVIKDSSSSTEGWIIIWDGMIDVVCTVFVYFIPFVAKALCFAISGWFHGHHLRSYLSALMLSAAEISFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRJ8</accession>
    <name>A0A8H5LRJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRJ8"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="237"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="702"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="792"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5366804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="863" mass="95010" checksum="5FD5023565E7B3D4" modified="2022-01-19" version="1">MYRFTSAGCMMGSILGGRLSDLMLIRLKAKNGGRSYPEMRLKSTVHGIFIFPLCVVGFGWVSQQHLHIAVICVMLFLCGFFSIFVYTSTLAYIVDANVGRSSTAVALNSAFRGTSAFVALEDGLGDGWTYTIVAAFMALSGLLTIWTMYKGQKWRQNAEEKEIKAEEEKQNKYESALRLLRRGARPGRPMPSFIAAMSIELGTRTVASSSPSPTSIPENDEFYSSWSLFLVCMLLILSLWTSYYLQIKRIRAVHETVVSIFAGMIVGLFTRVAANSEIRDMLTFKHTLFFNLLLPPIILNSGYELKQENFFRNFGSILTFAFLGTFISAVGVGILVYIYSFLGLESLHFTLLECLIFGSTLSATDPVTILAIFNQYKVDPKLYTIIFGESLLNDAVSIVMYETLSRFDNQDISLHSFFHGIGFFLLFFSVSMALGVAFGLAMSLLLKHSSLNMYPQIESCLVALAAYTCYFFSNGISMSGIVSLLFCGITLKHYAYHTMSRRTQRTSKYIFSTLAQLSENFIFIYLGMALFTSAPTTESVTSYVKPLFICITTVAVIFTRYASVFPLSEAINFLLKHGRGQRNEEIPHSYQMMLFWAGLRGAVGVALAAGFTGENAQILRMTVLVVVVLTVLLFGGTTARMLEVLGIRTGVEDEGASDSDDEDDMLRWTPGRRSSLGGRWGRYSDDDPVYANSRHSTYLPPNYNHHTQLITHPPLPHQTHGPFSAASSDSDSDGEVLPLAETSHEPGAMNGGRAPRSVLGEDGKWFQAIDERYLLPLFSNATASRTFHARRARRGVSGGTNGSAAGSAMGTPVDSEDEGEGHEVELGPAHPGIGRVGSDSRLERGLASPVLRSNSSGSEPRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSF2</accession>
    <name>A0A8H5LSF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSF2"/>
    <dbReference type="OrthoDB" id="3067283at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="85"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="271" mass="29722" checksum="E03C8A0C55FD4869" modified="2022-01-19" version="1">MLYLNFIKMFRIEDQVRVDPSDMSISPQLVLGSLDTYFEIVVGGLTKFDSGTMDEETLTLTTSTLVIIHDDDDDVFLLFLIPPPQQQRRKCSAKDNRPWQTTLIDRLLRQSGTLKRLSLQEQLQLTPAASASSASDPGEAVTCLDNGFITRVMDSNDLEKERGITILSKCMSIMCKGTQINIVDTPGHADFGGEVEQIMSMVNTVALVVDATEGLMTQTCFVLSKALERGLKPVVVLNKADRPPSWPAQVKSNLFATLGATGEQMVYGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUU4</accession>
    <name>A0A8H5LUU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="791"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1227"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1779" mass="200826" checksum="9DE09BBA914AB72C" modified="2022-01-19" version="1">MDRDDLDNPDAVSPHTHKVSGPILSYKDALHYVDSKWFMDLQRKARWMDLIGDFAGDEPFVLDGESLLQLVLDDPLLALGRVGDPASFQIVHAYQTLERFLKNLLSRSANFDIVFWQDNRYATLRVGESKDIVAPRALARILLHQHLKKLSSGTDFEVKTFQGLDDPSWREYENEKKPMFVMINHGGEPSENASLSALALVLLQRAFVYELLSKGFSVTSLSELEFKDSKILAFVHEGNYTSRSDVSKIFKMATRKKFAFDAELSKNYPGADTLFSDDDLQVPQAYPDIIGQLARQLLDGIVSPDSAKTNHRFLHPLTYLFVLHLALLEGVPLKLRARNVPALHPDVKHVLMNEFIPRAFFITAATLARSGASLDIDGRIFISLVHYVCSPGPQIAAELSSNALVNQIWSDLKQCPPNLGVFAAFAHGPTVSHPSRPTANGTNFGFGLLPFSNPVFDAHLSSVQIALDAPESLESFSSESNFDGSTLFSDTTHWHNSKSLLPPHLGGDTQKPLTQWQQNKRLKREQRFMSNLQKQAETLTGASGKIIQRIVIPAVGASSKSQSKQTARLPVQKAKPEKALKNKKLSSKDQLLLKIKQEKESKNKDSSSAWWLGQLAVLKIEDIPSQIKHLTSLINNPRSREDWAGTEMRLYRLHLELTRWVAESYPDASVVHDRYSLSILQMVKDICDRKYVTAPVSDVLSSVLRSLGFEDYARSLVSPSVDVRDDQGLTFSFIKLFRSKDQVPKYSWMKIREHPSEWQLRLFGEFMDRSMDGSPDSRVSFEPDAWQRKVLDCIDRRTSLLVVAPTSAGKTFISYYAMERVLRESDSGILVYVAPTKALVTQIAAEVYARFSKELKGKTVWAIHTRDHRIHNPQNCQILITVPEVLSIMLLSPTLAKNWLPHLRWVCLDEIHCIGQQEGGSVWEQLILMAPCPIIGLSATIGDPQMFSDWLGSVQRAHGFEYEFIQHPHRYSHLRKYIYLLDSRDNKLKPFKGLSSHEHTNRSRFIHPITTLSFGARFLPEDLALEPRDTLTLYHVLREVCTAPDDPKIVAALNGLNPGDFFPSTSGQLLRQKDVLRYEAQLKEIVSRLAGANDRLDSQSLLRRVIAKLDSTMESKVPAQQVNVTPPPKALLDNLIFFLSDLHVAGELPAILFSFDRTGCEKMVKVVNQALIDAERTWRAQDPTWSRKVQEWEKWKERAKDRKRAGTKQAKKKKDADDFPEDTTPSSWQSSFDPTEPSQQFSFADYHCYSKSELEEDIQSMTGWVQPWALSALRRGIAVHHSGMNKGYRALVESLFRKGFLRVVIATGTLALGINAPAKTSVFCGDSVFLTALMYRQCAGRAGRRGFDLLGKVVFYGLSMDRVYRLILSRLPSLQGSFALTSTLNLRLFNLLHGSDYAEISTRTVNSLMSLSRISLSSEVGQQQLLHHMRFSIEYLQRARLLDEKGRPMNLFAMAAHLYYTEPSNLALVALLRKGFLHRISRLNDTDAKQKFILLMCHLFGRRYLSKTALKPQYLEPLVKKYPSIIVLPSLDPDARRILVEHEDQTLKIYCEYAQAYCRQHAGDISDDCKLPLSQLDYSASQSSTSIPLGFHQYLEQTANRFTTRSLFVASSGHLDVFGTVQELTSTVTEGVHLHSHAVPSFGEIIAEGDEEKTLNAYLYDFYTHGQTPTLANANGIRHGDIWYLLQDFSLTLLTLKWGLEQLLTKISKEYTPPVAEEETLENGDGLENGIDDIDEENEAEAGGFGVCPPGVSKEDWRVYQVVRDATAEYQEKFKAMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX57</accession>
    <name>A0A8H5LX57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX57"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="13961" checksum="C14B483E4DE8B4DD" modified="2022-01-19" version="1">MADLEPPYVLHSKLTLRDAMVSSVAFSTGGDLVAAGTKSGELRIFALGNKYPPASYQLASCITALIWGKDASSEMLFVGEINRHIHRASKHLMQQHHDFQLTTFKDVKGPITALAVSNYARLLFAGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXH1</accession>
    <name>A0A8H5LXH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXH1"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="294" mass="33725" checksum="6BBC80950D22CEA0" modified="2022-01-19" version="1">MSTTFYPLASLSQIESTPSREDGIPADLEEDLRAYGCKLIQEAGILLKQKQVAVATAQILFQRFWYVTSMKQFGIGDMGMGALFLASKLEECPLRMRDLINVYDLLLQHSEHEHTMGPKSNTEFKYAPMSYFGSTFYELKDTLVVAEMQLLKRLGFNVLVVLPYGTLINYLRVLGLTSREDVTARAWGYLNDAMQTPVYALYQVPTIVCASIYLTTRHMRLSLPSEPPYCWWELFDAEWEDLWSVCGYIMRLYRDRSDEERSIVVKMVNKKEVRKWLEDHSQGNEGSSNGTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXN1</accession>
    <name>A0A8H5LXN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXN1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5373134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="361" mass="40345" checksum="31962BAC325A427A" modified="2022-01-19" version="1">MPPTRALRSRIVKTQYKPEYRIESKASLKARGVTTQQCPYCDKLLSITSDLYRHIKTHTEEKRHWCEYCSYGSYQWINVKIHQRKHFSEKPEQCPNCDFCTKDPSSLTRHRKRWHAYVPPPRRERAKQPKKSVGANVKTEDSDKEKSSTSTIPAPLPHPIYPSATTSASMHYGSPAMYLPSLPNQNVGLPNPLYTSNWPYALPPYAYYPSYSMDPALQNSSHSNVQASRTGLGYHGQVIPGIFPGGYTVGHSHNGNGKMRQVGQAFGSQTHFNHFDISGHHEAAYRHGRGQGHISMDTVFPGSHPSSFPVSAPSTASSASTRELPQLLPFDFAVDAGWTDWDLDLDCLDGRSSFESSGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY28</accession>
    <name>A0A8H5LY28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY28"/>
    <dbReference type="OrthoDB" id="3053346at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="207" mass="23743" checksum="1A069CA6778AC422" modified="2022-01-19" version="1">MLFPILPNLNYPTCPQHNPVTPCQPLPWADCCISGLVRIHDRCETDWVEATDGFTAPYQITLRAVRTSGQIARDVTEVTQAQRILRLKECDTDDILSDRTIALLCNPREMDDKFVFKCLTDLSTVDVINHPDELFRESAKFERLKATLEHERKRRQIEDARRIDEEYFAGMRPATLQSPPSKFARKPGAALMKLLSDKLCKATPEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY47</accession>
    <name>A0A8H5LY47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY47"/>
    <dbReference type="OrthoDB" id="2935283at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22890" checksum="0236D24692EBB50F" modified="2022-01-19" version="1">MPSIRCRNFLWCLSLRSGVCILAVLGFMLGALGAAMGWAKVSLMLGQSLSVKDEAILFILPSTFSLLVVISLLGVIGGIARIRSLIFSYPKLLAVHFLLLIISFALSLYSAIHSSDLSETQCDAESLSKFMTDFCKPGWSTVNVLSVILFAVALLVQIYNFIIAINFAEDLDYDDAASTKDITFPDAKSKNSTFDLSTTSYDEFLKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AS69</accession>
    <name>A0A8H5AS69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000659">
        <property type="protein sequence ID" value="KAF5309277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AS69"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5309277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="133" mass="15338" checksum="3BCA36D9A445C3C5" modified="2022-01-19" version="1">MGDQHKRRLIFVNQTANQNTTFYAEQLFPNFGIQQDRETARQYAGLGSQLNQINLIQGECRSFKGEFAVPPATHGMDIQYYFPTGFTSSPFQNADFQKAFSQSFLAFAIPWTLTPNLIHQYNPAMEQVQRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ATR1</accession>
    <name>A0A8H5ATR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000593">
        <property type="protein sequence ID" value="KAF5310403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ATR1"/>
    <dbReference type="OrthoDB" id="1718410at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5310403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="306" mass="32789" checksum="9EDCC0EC21D54AAF" modified="2022-01-19" version="1" fragment="single">MYKGPLEVPSFSEEPPMSEETWIAIEPPKNDAISSSRQAERNTNTNPTDPPSFLESQFDVVLRRQCVRPSNTVTLKQTTVPSRFLNLSNEFEFSGWGTLLRLQLTEEDYAAGEAVVKARQDEKVLGQFTASALAGNAVLGSVFYALPAVVGVASVYSPISLLIATVALFLWRPIMEELGSAFPMQGAPYSYVLNISTKPLALLSASLLLLDFASTSVVSAATAASYVTGELAASDLSSGDDASGSDSLPFPEWLVAILIVVLFMFVSLSGIKESARVALGVLSFHILTMTVLIIVSAIHFGRIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AV62</accession>
    <name>A0A8H5AV62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000542">
        <property type="protein sequence ID" value="KAF5311554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AV62"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5311554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32920" checksum="D720F978E5BF97CB" modified="2022-01-19" version="1">MRGKSEINNLVNQMHEVMAMMADLDPPYVLHSTLTLQDAVDVCTLAFSPGGNLLAAGTKSGLLRIFALDNKYPPASFQLSSAITALIWEKDANTEIVVTVLFSGNSVTTSTAPSRAPSRASHTSRAPSSTEMKDSLTAQAILVQTLTSVPFPKSITTVGKMTTLVLTFSLSLSTLPLPTASITHIPYPRHPLSPVPSDINMSEQAQQPHFDMHRAEQIHQAATIQDIINAHGLLQEQVTTFLQHINQQQPQPQAHTISQSSDKSSMAKPEPFKGKAVDVRSFLASFRNWAGEQRDIAETKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AWN8</accession>
    <name>A0A8H5AWN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000547">
        <property type="protein sequence ID" value="KAF5311542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AWN8"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5311542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21602" checksum="8B1998007BDBD86B" modified="2022-01-19" version="1">MNSQVQKPRHLPGCYAVIPFDNPEVLNYVRIAYAVTQLTILAVYYYVTMVVKRKNDQTVLKYVEPASPMSPDQEPKLITQTVRDYDLTEVSKLVCLSLPTIRSDYLEANLSPLSQHQLRSVYIGIAMMAFLHGYMKFTQPLFIQSLMGLKGLYDAKPVSIHILGKNDKEGDLKRPWKAAPGMFGGECYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7Y4</accession>
    <name>A0A8H5B7Y4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000456">
        <property type="protein sequence ID" value="KAF5318242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7Y4"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5318242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="632" mass="70404" checksum="2DF6497CD600706A" modified="2022-01-19" version="1">MVQLLLDLRTLAEDTINTCFVDSTFSPDEATAASVPNSPSSSTTSRARNKSTVVATSATPTSPTASTRFKAHRSKPAEMIARYLDKAMQKGQGAQSTKEYERTLDKAVGEEVVDWEECELGCGAENGYDPKFDLGESMFNDLKLLEDLMREYPVWEDKTKKDELKAKYKKLEQDKQKKNKDIDVDKIEDALAYDGGTQCLAFQRPEEEIILSLALGFGTQVAIPTSAIHTPIALFPTPFPCVQFEQASTYNTLYARIALETEFLDEVMGVGKVDDFVGKLWTGWKALRDKGLQQIAMFQYVFNTISSSFSTLSQKVSEMHRHVHLCASTGFYDSSPYLQADNLPPNDTIAGPVEGLAAAHTAYDVPRYVSLLNICLLLSLSCTQILFIVQPGERNVFDQLWLEYELLEKHSIKVIRLTFDELSSCASVSSINAPLFTTSSSLHFPPGASPSSKFPLSTSAQPTPPPTSPPHPTTSTLKSLATQLHRHPYGLPPSPSRMELIAQNKLNDVMEVGVTRFHFSIQENNQLPLNFTHEYQAANRYSLHQPNPIPSWFRRACLENPRPLPDFTPSTWHNFVVQVDWDQRTLQVFYSTDGETLEAVTDVVQICQMRVLGVSAGAGIQVTHAQQDQDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BI27</accession>
    <name>A0A8H5BI27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_018350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000389">
        <property type="protein sequence ID" value="KAF5323670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BI27"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000039">
        <property type="entry name" value="Glutathione S-transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5323670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="36544" checksum="E7706E1623F298C8" modified="2022-01-19" version="1">MVIGLHLSKPRIVVMTLPNSGTSPATSATQTPPPSLQAPAQSWGDHAGCILTASPMHASKLSSPVGLPIQSCFPSTDGYRSFAFAFGFLWTLELRTHLIRVHRLYSSLTMTLKLYGNPNSVNTKCVAVILYLKKIPHELITVDIITRKDNLLPEYLGKQPFGEIPYLDDDGFVLYESKAICRYLEERYGDHGPALMPSDLKAKALFEQAVSVEWANFEAYAMVAGVEGVLKPKFFPNLPFNKALYDQAIKTLSMKLDVYETILAKQKFLAGDEMTLADLFHLPYGELLAIGGNYIMTTKGPNVKRWWTAISSLPSWQAVKDKVPAGVVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTV9</accession>
    <name>A0A8H5BTV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_017147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000345">
        <property type="protein sequence ID" value="KAF5329121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTV9"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="90"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5329121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="452" mass="50925" checksum="5AB42A4F1EF42941" modified="2022-01-19" version="1">MSQQTSPSDVDLKDALVSLRASNPTLGIAKLHALLLKTHPDWLVSEKRTKKFLQNEGLTIVDLATGPSKSGSVYPSSRLIPNLEIQKWSPKVEVKYFNKKKGKGLVAKEKIKEGEAVWKEDPFISAPEWEIYDFQAQSAGCSFCTTPFSSTITTSLIQSCPASTSAAPCPARFCNRLCLARSAKHHPFLCPAQNPASVPLMGWVREIQWMALHALAQLTSRLLTVGQLDDKLLDEEWRVVSSFAQMSLEDREKYHFSGQREPDQAGWKKAYQLYLEAFKEPKSAADQKKLAKLLKKPVKRDLDRNLFEYDSFLTNLGKMSLNLEAHGGLYVLHSHLNHSCTPNISIRHLDQRTALARITVIAKREIEPGEELYITYVNPQLGVRSRQNELEAWGFGRCTCNRCVKEEKEERIKEQERQRSKSEFATEDATGEGGEMDMADLEKELKAGLGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYU1</accession>
    <name>A0A8H5BYU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000314">
        <property type="protein sequence ID" value="KAF5332059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYU1"/>
    <dbReference type="OrthoDB" id="3059882at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5332059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="23346" checksum="1FC37312F8ADE948" modified="2022-01-19" version="1">MVWLTATRTAKLLPHLWYRPQDIIYVPAFILFGYYFAIMKLYALCTLHETAWGTRTGIGDIAAATAAMDKQAQAQGQGLDESASKRPIEKIPLAFGSRSDSVYGSGSGSRSRSRPSSDLGPSPGPSPLSSSYPPLIQIQKDPFADDTHAHAYEYGYRYGERLDGVGGSADMGMVGSTSFKSEVQGQGYMRKRGDPFGDAGEMEMGAGLGSELGSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZI7</accession>
    <name>A0A8H5BZI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZI7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5332435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="8237" checksum="D4C8F4149F0B83B7" modified="2022-01-19" version="1">MSPLELPPSSTYDSKAQRVVDLTVRVEKIGRFPEAHSGFVDVWKGVWKDVHGHESTVAVKVLRSRIGDPNPQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0R6</accession>
    <name>A0A8H5C0R6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000293">
        <property type="protein sequence ID" value="KAF5333019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0R6"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="100"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5333019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="463" mass="51566" checksum="3F1F8D6F0375FB85" modified="2022-01-19" version="1">MSIASLTTSEKPEPTSSREILPDEVYEQLLSQTSRARKSAPIRHLLHLESCPNMLSMLAGKPNPEVFPYVSLSMTVRSPNPAIDSSLNEIVIKDEDLSVALQYGITSGVPELVKWLTEFTCRIHGCQDDEGWRVSMGAGSQDLLYKAFSALVDPGDAIFVESPTYPGIIPLVHSLKCNIIQIPSDAEGLNPSSMASMLENWPEDKPLPKVLYTVPFGSNPTGTTTTLARRLEILRLARKYNFFIMEDDPYFHIYYGDFPRPSSYFALERKIDGPLGRVLRFDSFSKVLAGGLRLGWVTGPERLIKAIDLHNATSIMCPSVISQMMVYKLLQNWGIEGFLTHATHCADFYRQKRDIFEKYSQKHLTGLAEWITPNASMFVWMKLRLPESASAKTVKTVTEGEGGDSAAFLEHKALEGGVLLLPGECCYIDGKKGCQVRLSFSVLSEEEVDEALGRLAKMLRSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2S1</accession>
    <name>A0A8H5C2S1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000265">
        <property type="protein sequence ID" value="KAF5334202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2S1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="377" mass="43090" checksum="A34D919FCC1B83EE" modified="2022-01-19" version="1">MTALTRRLRSLWTNASLCFSPAHIKALRILLIPFRDIIPTQSAMIDDAILYQVEEFFRTGSARFSADGNIAVDNLTNKILDQYGDLSDPCHHLAYMITTIMHFSRNYPDLFINSKLTYDAYIGKDSYGTVHESLWHREAVAVKLLHRSFLEKTYNSQNLDEFFERLEAWKQLYPHRNIMPFHGCYAAVNFDTQDIELALVFPLADGGNLKGYPETGKHRRRFTVWWDKLVLLPIHVLTIIVQMQGIAQGLQHLHANRPPIVHGHLSSENILITAGSKRVLRLGDFGLSYIVGLNVNRIKETDFTGSNVTDDIFSFGALIYELMTGISQPSSLHRRPDELQGKDWDNIWGLLQECLSDQSKQRPSSARVVNRLNSFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4S8</accession>
    <name>A0A8H5C4S8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4S8"/>
    <dbReference type="OrthoDB" id="3243926at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="497" mass="54826" checksum="99050D2BF1D4AA30" modified="2022-01-19" version="1">MVLPLLIEVAAHYVAISRFCRGRVRYNAEGIIERSATVFVIILGGGLDKITHGFQYIVGNVSIGGESLGLIICGVVTFLLLFSLFFGTPEPDEVSNRRAITLFFFQFFYLSAIIVTLQGIATMLTVGNLGNALEMPLDFLRQSKSIMELKGFPNHLNESDYASSNIQHQLEKQGVPMSDLLNFVNSWMDIADDDDHTDDPDRFKYPYNALLQMDVYVVERVLWNFDSYPDSGILLAQLDAFYQPDPDNITLVNNQTFNDVVEGVIISNATPALWFYAAGGSVLVTLGLMGLIRQWPRDRYEWGQTISRLLMGSAIIAFTAIDIHASNSIITDDFYYEGSRIWYLATHSLVLPPYAFALLVEQVIELILLGLAGRALSDFGSSTSALTRSMTRARPGGGGGRGGVGGGRYTRTGTSEHEDYFVYAEPMGQKGGFHSEAFGAFDSEAPYDPDNKVYPRPLMMSPPSGAPNFGPRVQKVNLRPGSGHSRRQSSVQSLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6Z5</accession>
    <name>A0A8H5C6Z5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6Z5"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25384" checksum="A0E8D4DBEB908CC3" modified="2022-01-19" version="1">MSRQFFVPGIILLFVALVLSFLTSISLPSIHFLDIARIHFGNGQGQNLPKDQLIQEARFGIWGYCYYDLNDDSTCVHTGHGYEFPLRASFDGDTNTITVETIGASWTRGLAVHPVATVFTAIALGLSVYSTVTGNIAAALGVLVASLLAAFLTLLAFIIDIALYAYVHHKVHEVDGRWNVDTAPGFWLTFVSLLCILFATCTIFIGRRKAGDSSPSYPTMSGGSGILSRFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8C1</accession>
    <name>A0A8H5C8C1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000220">
        <property type="protein sequence ID" value="KAF5336798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8C1"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="237" mass="26149" checksum="A54B63CD22B709DD" modified="2022-01-19" version="1">MQCTQVIECGALHQHQSQAQFKQGGTRLGVGLFMGVSPTNTAAPTSTTPPPSDSKTNAVNLSSHYIPVTVSVKPSYSLRQLHVQPWSNPTGSSKPSLNKNPNRRGIESWLRRWGSMSVWGIVFGNVVYNGELVAFRRAVNDKFLGGLDKAFADDWKFDVREIKTKRSIHPPHRHTSQYSNPPPYPSTSTSPTCDWDHHSYRTTSSLGKLADPRRESITPSFSLAAAASSTSLWKPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBJ9</accession>
    <name>A0A8H5CBJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBJ9"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5338792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="24384" checksum="B6F65BA071F0BAFC" modified="2022-01-19" version="1">MSSSLGKPLTEEKNPRGIPKAPFIEDVEKYLGGPDAEVEEPLKNFQDAIAKYRYMDSNLAQRRVGLEEKIPDIKKTLSMVEFLRDRREGKTSTEDDDDLDIDEDGAEGSQSKPLKTTFELNDTLFAEAELEDTDTVYLWLGANVMLSYKIPAAIELLKSKLEGAEATLASVIEDLEFLREQLTMMEVNMARVYNWDVKRRKENRLKAEAAGKSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBT2</accession>
    <name>A0A8H5CBT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBT2"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61823" checksum="11694D0901F5961D" modified="2022-01-19" version="1">MVAPGRIPSTSKVSSFWLVLKASQPDFHGTETVGADLTKKRIAQQDYVKPSSPVENLPTEILTLILALACPEYGLDVIKRAGGFSCPSTVPTLAISHVCSLWRNVVLSLPSLWAGIRLDLALLTGPVDYHFREIMRLYIDRSRRVGLDLYLEASGLQKLSRSQQQIAFAQHDSIIRLFLDERPRWRRVSFDVSHDISIFGYMQELMGTFEHLEEVRFVRAVLYNYQPYDAALSDDEPYCDAPNLRTLELSSTNVFDIEVMGTIDFKHVTSVILNNCYAHAWQHIGEVFRLFPHLQQLSIHVDSYPESFDNIPHRSSQTLQSLTMIVESFGAAAEVNAALTLPSLTHLNLSFHSSCKSDSSKAAWMDSFQAMLRRSSCQLQSLNFVCGDLFTTDEVTKLSSWLPTLTTLSLDADCQTLSTRFFENLTLHSSLAVPSGSEGVSDAKLVPVFPRLTSLDIKLSGLHIQHTQPSTSLPIPESIVSMIQSRQAVITITGTDATLSHFGLCALAREGVESEREWAKRLRSMMTVRLREYRDASTGHRRLTHSLELGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDM5</accession>
    <name>A0A8H5CDM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDM5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10052" checksum="36C7BAFA852D1446" modified="2022-01-19" version="1">MKKEQAEKEEEQKKSKSGPGLGLLVDYGDSDGSVSDDRDPADDIMRNEEPGAEALEITAMPPPLGPGQDDEAAMQARRARAKEWVEKRRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEV5</accession>
    <name>A0A8H5CEV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000184">
        <property type="protein sequence ID" value="KAF5339503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEV5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5339503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="183" mass="20981" checksum="1190446026355AD5" modified="2022-01-19" version="1">MFSLASVLCSMVQPCPMEVRRFSLKTMSVQLGLQNQNQTPEQGQCFMPVPLLKQNSLFHDIGPMCFVQAPSLVPWMLEEVPLEVIGDRLLWITFCYDNAWGGMLWQVVIGLEFLWPLWDTLSSCYRLAAYSATIYWQDMEILKEILYFVCFGAAHLEKGLPSLDLTFCSLRLHSIDTPAQKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJP8</accession>
    <name>A0A8H5CJP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJP8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5342992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="60" mass="6769" checksum="EE9A9ADB9EF5F8D4" modified="2022-01-19" version="1">MYTSLLLGTLEYFVHAVHARTSNSFKFDFLVIIKLEKHVSLGERAAFSFQDFSTTVSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKT3</accession>
    <name>A0A8H5CKT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonan lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKT3"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="197" mass="20997" checksum="6DBCDFB0082E5720" modified="2022-01-19" version="1">MFCIKLALRSQSVTVSAGGMTTSNITSMFSVSRIRPQTDKIKQSLIWQIGDLDGIPRGFLNADPSDTCMSRWGPVTFTVGQAVSSFPMAIFKTSGCLIPKPLYNQSKGSRLHHFTLNSSQGSARTLDIFTTLAFTGARPQITLNSFTGAIPAVPSQPDLCGVTHAAGTLKTDGSTNVLTINAISGSGGDRFLYEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL32</accession>
    <name>A0A8H5CL32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000135">
        <property type="protein sequence ID" value="KAF5343729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL32"/>
    <dbReference type="OrthoDB" id="3188866at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="382" mass="42459" checksum="1ACE8273A1474BA2" modified="2022-01-19" version="1">MELSLESYRIIVNNVQSRADLVCLCRVSRSFRQVAERALYNTLLIRISTVDSISRTIALCETLEKQPRISSLVDALTILVANDEEVSGDEGANVASEVQAEEQNGESEEQEELAAALAMSLTENVEAGVQEASTSGEGEDEDDDREGEENIVGVQRPDLDHCWTCISLALQKTTNLRHLNIHISSNIETSVAWILTGSTFRLRSYHCDVTWDHRLVAFLNLQDELEDLYIIDYHDLSGLGHSSPLDSPSSSLAISPDSMEAPSSSISPNALRSLHVLECTFTEAATTLVPGRPVIRLKTAFSSSILSAKRMEMKALFAATWRSTRRMRSLDIGDSVYTEEFGTEMLQTIVAHSRTRDDLRYLGTLVLPVKGNERLMFYALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLV1</accession>
    <name>A0A8H5CLV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLV1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5344100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="454" mass="50638" checksum="688689BC252E1EA4" modified="2022-01-19" version="1">MPRGSPSDSDSMPNFSGFLLDNRFKLLDLLGSGAYGRVYKAVDLSATPKGSCFFAVKCLQRPPSGSRREIFQIRECSHQLLVSDHPNIVTLHKVFQDHNHIYVVLDFCIGGDLFSAINPKNIFFRNDALVKSTFLQILDAVDYCHQRNVYHRDLKPENILCSEDYAQVFIADFGLSTQTRASKEFRCGSAFYMSPENLSKDLLSYSTRCNDIWSLGVILTNMLTGRNPWRLAVPVDPCFNAFRNNRDFLRTVLPISEEANAILKRIFHFYPNSRIHIRDLKQEISAAQTFFMSDEELRAASEAVRKVAEFCGAVLSLAQSSPVQAISPEPESSDGSAKQVVILATPATPVSPNNWAQGSSSGSEDDSKGPVTPETRPVQPVVEVPDLEEEMEQQIVRTPVIQFHPASPHLDDGPRHRAPSSSASKPPPRRAGTQLFKKAVRRLKRLSEPESLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMG6</accession>
    <name>A0A8H5CMG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000125">
        <property type="protein sequence ID" value="KAF5344415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMG6"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39939" checksum="834A83B1301D1A9A" modified="2022-01-19" version="1">MASDALEIPDASNIVTLDGTEAGCENDMIRCEASDNCSLPIDIILRSSSDPLTRFGTHKLNLQIYSSILSLAPPSNEPASPGITKDPSTTRSDVSSTTSDANSTLQTASFNPTDESKDVYLPEDPDVIQLLLKFMHHQPQPDLRLISSNLLLRFANAAEKYKVYCATGVCSVVLEFSVKEHPFDVFLYATNWGYTGLQEVAAKLAMKESPARFFAYAHSINHVAWRDLAEQETHKLPTKQVHDSFKEYCKDSGSWAEAFGAWFNKRESLRTALFTALNNPIPVQHKGGLSHCDEWHSFYPQLLGKMAVEPPCEESFLAILANLKPVLKNCDHCGIVLKAMGRSVRVATTEGVGKRALREFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNF6</accession>
    <name>A0A8H5CNF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNF6"/>
    <dbReference type="OrthoDB" id="3015170at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="78" mass="8863" checksum="E6D56FACD839065E" modified="2022-01-19" version="1">MGEIAQDQLLTDEAAETALETYEKWETKEAKVKEIIFETISPVTYYQISNEHTAASMWNKLKTMCEHKGAMAAADIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNL5</accession>
    <name>A0A8H5CNL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000128">
        <property type="protein sequence ID" value="KAF5344191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNL5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="183" mass="20189" checksum="FFD4BD4D5D82208C" modified="2022-01-19" version="1">MTSYMKDNAPRFSPNPSSKHLAKANSSTENLINTLVSKLTGSICCYFRLGRSHLQTSLLRVSYLFQVSSAVPSTTPSTTVPPTCITIPPVLRRLCLLLPWHMLYNLPQSTVAVVSGYTLEVSSILVPLRCELGGDEEQERETKYKPRPKQDKAHASGNLQRYGGYGSIPPIPNYTCMEQRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNP8</accession>
    <name>A0A8H5CNP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNP8"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034286221" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="5">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="186" mass="21103" checksum="B8CF3F3425439D87" modified="2022-01-19" version="1">MRLFNTCTISFVRLLLRLKNGWWLSASSRKPGRCAQIFVKDSFFLPIPWVSLAYVVNNINTPKSPGATEAVGLVDNRDSIASEGKGEYMDVHERILDTKGNPIPNAIIDTWEIDENGLDDTQYAEQDTPDCRGKLESDVEGNYFFRAVVRDAFFGVRTSLIMDLKRIDDPELSASRREFPDTNKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP42</accession>
    <name>A0A8H5CP42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP42"/>
    <dbReference type="OrthoDB" id="3198848at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="19317" checksum="711D7E14317AD6D9" modified="2022-01-19" version="1">MPVMPQSQSSPFAWHALANRAIPDIITYRLDDSLVYVKPPTDYNEAIDLAIKEYPDELLDLARHRISFTIQATMNGTRRTVRISESAWEETVYKMVRGEVISIEILPEDRKLVEAPPKYVARPTPASESHLSMSCSENSNEGDQGDIAANTLNATRRLSTPIRRFPFWCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR79</accession>
    <name>A0A8H5CR79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR79"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="487" mass="54924" checksum="549E5DFFF408340A" modified="2022-01-19" version="1">MSVKVSDTMRNTPGEMGRLGGSDLWPYTILSEPTLSSELARLASAQIIDRRTHCVSFQPNGIPECWNQDRYVVKDIDVGFSSPHDARLTWRLRAVFDGHLGHELVNHAAAILPSTIQTALQEIEPLSKSENDPETISSLLQHCIISFDQSIFEDIMSFLPSAEDLTSSSVSDEDIRRIINDRRVERTDSLSNYAKIIRSMQGSTALIALISPNSEKLWIANLGDCQAGIRNPSSGSWDTLPLNTPHTGWEEGEADRILKEHPNEPDVILRGRVLGAMGITRALGDYHYKLASIYTDRVFLNMDPPGWLGTAQEDHEWTRSIMHRRNLTPPYLSNVPDVRYFDLRAHHSSGYSEGSGVARANGYEILSSARQDSNVESETFTRNACLVICSDGLMDLYKRHEKWEDLEEVHIFERWIELALVDETPAFCLNAEVVPKNNSDPRHSRNHALRILRDALGGEDEERVSSMITVEMEEKWMDDTTVIVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRL6</accession>
    <name>A0A8H5CRL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRL6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="123" mass="13757" checksum="BC8E358C7AB45CBC" modified="2022-01-19" version="1">MFKAPVEATIAKPATGGIGDQGPNRRRRKAQMETTVENLLDLLEHCNTTSEESKRATEVSGAKEARRLALETGGKDEVVDEDDELKCTVTTLVEENYKFTKEMRGLDEKIVSLKQSEWAGWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS43</accession>
    <name>A0A8H5CS43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS43"/>
    <dbReference type="OrthoDB" id="2834295at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="278" mass="32108" checksum="2DF190E3A573689F" modified="2022-01-19" version="1">MAKVPPPQRLSQTGVLLPLAVGTSSVGVSKDPGHPQPLPPNQTPKLQSHPIRRAPPERWSCIFINVLDEFEKNYLSLSHRRLKRHPLLRPRPLQMTPISPSFRHLLLLVDLQQYDIDVDARRSKPRLLYVTALLRLWLSRSRVPCSLTVKELQTTYKTTKLSIYERIYEILNLLWWYLTTDAFCIAPNLRRVILPIFPQTQDVPSDLPDEDSGLRLPFHQLTSLQINRFSPYKAHFYNTLHLLPNLQRLTLSCRYTFVLEGTITSNLTTATIVDVLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW57</accession>
    <name>A0A8H5CW57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW57"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="414" mass="47504" checksum="180BE21393F644D2" modified="2022-01-19" version="1">MTTLRTKRRLRVVLLVFLTAATLLVVPYYVYYRPPYSLYYALTDTELEVAHDYLSREQDLKFVVFNQLQGAGFNNQVQEILLYHHLALVTSRTYVYQPFIWRPRNHQPLPLSAFLPNPTRNTVPISLLSRICPEDSDSTVHITVDSLYSELWDKSQNILNRPERCIIIDNRIMHWNYLASPFVGQMWPSFQAYLSKHFEWSPQIIDIVKRTQEHLELRPYSVKHEQGDSYMAIHIRRGDFSGHCASLAESEASFTTWANLPSLQSSVLPPALDISHPENVMLHCYSPLGRILDAITLQARRHPHIRTLHILHDAAIDHPIVWLDVLKLETALTDHDWAARNGWGESGPIRRITHTGMIPLQRGEYDFEIAVDVELARLADVFIGNGYSSLSSQIIALRMGTEDANGDIGDITLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWR0</accession>
    <name>A0A8H5CWR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWR0"/>
    <dbReference type="OrthoDB" id="3106749at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="24416" checksum="F3D6290BF46CF53C" modified="2022-01-19" version="1">MPRFIPFLLPRKRKDDDIIVGKRTGGSKRAVTYVRKSSYANLRDYVPSHPAIAYTQRGRTSWCDKTYPEFQAAVYEARQRNQKQRQEEYLNARVEELNESRADMGLPSWRFHSSEREGNLAYWYGSAKGKAPLRNKRVDDEELEIARARSERTREMRALEDDAGSTITRLLTRLFKRRRGRKPSKVRRMFVNLRLLFRKNKNMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXI7</accession>
    <name>A0A8H5CXI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXI7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="6927" checksum="860EB150DE280523" modified="2022-01-19" version="1">MPTIKDMALNTLSIRIFPSTSGRVLSLMDRLNSQSTSPAPTQPSFVRRLDFEGEGEEGGDGNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYN4</accession>
    <name>A0A8H5CYN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYN4"/>
    <dbReference type="OrthoDB" id="6613063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="109091" checksum="89B70D9568E9662F" modified="2022-01-19" version="1">MPRSAKQWCEHCQKHISQQRANEHWAFLFNPYTTARLPSGSTTASEAPGNYENTEYWNEPFNDEEAFLPEDNHLPNPAHLQNIRAWVEDGDEDEDLMDMDGWTTRELDDKDESDSEDEEEDFDWDGFVRRYCVSSGNLSPEDRLGAAFEQEASAATLAEYDLAICRAFAYKLTTHTTDRAFAKTPYAFPRHPSQLPLPKLDGIRSRVTALSGVVPRLFDCCPNSCCAYTGRHADLDTCPYCHGKRFRANGKPRKQFTYIPLIPRLQAFTRSTDMVEKMQYRAREHKHKAGHLNDIFDGTTYRKLHRRHVHINHTPLPHKYFEDERDCALGLSTDGFAPHKCRKKTAWPLIIFNYNLPPDICFHVEHILSLGVIPGPKKPHDIDSFLWPLLEELSLLARGVCAYDVLNNVIFSLRAYLIAVFGDIPAVSMLMHMKGHNAKSPCRMCSISGVAGPDSRTYYVPLNRKWNIGDDDGNNIIQAYDPHSLPMHTHADLLAQAAEVQAATSNMQAERLSRAYGIKEIPALSFLNSLIFPTSFPYDFMHLIWENLVKNLILHWTSDFKGLDEGSESYTLGKAVWEAIGSETAASGATIPSAFAEMWSFWTMYLGPVLLHKCLGKKYYDHFLLLVKLLTKCLQFEITTEEVNEIRMGFIEWIQKYEKYYYQYSAGRVSACPLTIHALLHIANSIEVMGPLWCYWAFPMERYCGSLQPAIRSRHYPYRSLDRYVLETAQLSQIKLRYNVCEELKLGPSKVNQPQGSSVLKSDSAIILCPPKAQSKQDHLSAGLVTAVCAALVTRFDSRNITIRVVRKHFQSAHVEVWGCIRQVDSEEGETIRASHVGGIASEDSRDATFVQYEAYVDLHARKKNHRRKMVLQQFYGQLERIIVVSFSDPDACRVLRVSAGEEICLAGIRSCKLDNKQPLRDVDMYFYSSTGALDVIGIESIQCLMGRVKNRNKTGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZR5</accession>
    <name>A0A8H5CZR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZR5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="27543" checksum="0A437A3965FA3A36" modified="2022-01-19" version="1">MYLQRRRNLHSCALVCSDWQNDALDLLWEIVDSIEPIAMVLGTIKRRNPRSYKDKMLVFENPPDLAAWGRFRIYNNPNLPTAGNDSSDLVLDALNSFRHLDHLDLGYSSLDPAWSRVVSMILSQILPLDCQFDVEEQYKEEHSDAAWKRVKEELEIIRAYCRGSVVLPSSQFDVEEQYEEGRGNAAWKMTKEELEILGPVAEGALFCPVLRPRSWDFLVIYLLGHYNINFLRPSLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0R4</accession>
    <name>A0A8H5D0R4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycoside hydrolase family 28 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0R4"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5350919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="52163" checksum="1757CE21A76C4569" modified="2022-01-19" version="1">MLSKFKSGDAEGMVFHDISSPTRAIFPSKTKCLSHRKSSDDTLQHQLASLELHKWLASDRGDSKGYLYRLDEAFGGDTTMKTFPTIIRVAPVLFSYLNLVYGGTVDRQGSTCTVHASDDSSDDAPAIVDAFEMCGQGGQILLHDDLYHIETIMNTTGLKDVVVDLTGTLLWGTNITYFRANSLPLGYQNQSTAWVFGGDNVTFNGHGIGTFDGNGQIWYDFSNGTSNLPGRPINLMIANATASHFDGIRFVQSQFWTMAIRDSIDVLLENIYVNSTSNSSASTGNTDGVDTIFSDRITFRNWTVTCGDDNISIKANSTNILIQDCVFNGGGGVAIGSIGQMLGHFETIENVTAERVTVTGSAFAAYIKTFTGVQLGGGGGLGFAKNLTFRDFTVNQVKSAVAHIGQCTSFEGNAGDCDTSLFQISDITWSSITGSVAGGTLASFQCSGSAPCPGIELVDLDQVTTQGSRNITCSNVVNPVGFDCTQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6A2</accession>
    <name>A0A8H5D6A2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6A2"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034520837" description="Hydrophobin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5354364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="225" mass="23519" checksum="D94A4DB770801172" modified="2022-01-19" version="1">MFSRISTLFFTAILLSSANLAIATRLPDHQDHHGDCDKYPHHSHHDHHGDYPHHGHHDHPGHCSPEPPLTTTVTKTITRTAPPTTVTETQCCNTGNPVTQTITVTAPPTTITEPGSPCNTGPPVTKTITETAPPTTTTEPASQCNTGPIQCCNSVQKAGSDAVTSILGLLGVVIQDLEVLVGLTCDPISVIGAGGNSCSATPVCCEDNTFNGIIAIGCVPVIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9Z7</accession>
    <name>A0A8H5F9Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000344">
        <property type="protein sequence ID" value="KAF5329216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9Z7"/>
    <dbReference type="OrthoDB" id="3262464at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5329216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16040" checksum="DD6EF7CB2BDA2729" modified="2022-01-19" version="1">MYNTDELSITGNETNCFSKHIPAGARCIPVQASAVPCERAFSSSKETDADRRSRLDPVFMEVLRILKAMYHEDRLNFTKSWVATTPELGEEKADGTCTMDEAVNITMTDMSREKLKDMLINGQIQDIARLINASYGISPAESNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCW8</accession>
    <name>A0A8H5FCW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCW8"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="341" mass="37049" checksum="FAD0F9F95A5B41DE" modified="2022-01-19" version="1">MGGSPSKRGNEMLLKEMKVKKTTGYTTFNKNFLYTADQHLYAKRWEALVNSSFPTNDSPSNPLNIDIIQIVFWNDYDESHYIGPIKEAQPTGSKAWTGGMGHAAWLPLTSYYASAFKNGGQYPDISKDEEKLVMWSRTHSAQAQVGDPVGEVTGKELVEDTVWTITLLAEPANVTFEVYAYTPSSNANDNSSTIISSQTFSVPAGLTKLAMPIGFPDADEGIQSLSVRARVLRSASGSGSESQDEDTQQNQDTTDTADTLVMQLDAGNPNASDSNANTGNGDGDAQGQGQGQTLAPFVFVKNPEKYNYNAWVGCVSSSGWGVDLVLWCCGEGGRRVLMLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FE62</accession>
    <name>A0A8H5FE62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FE62"/>
    <dbReference type="OrthoDB" id="3221808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="90"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5333805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="878" mass="100203" checksum="10C95475A7416FB0" modified="2022-01-19" version="1">MHFNFNWLTKVFKSPRSSRAPGEAHAMNNMENGFSANHSPPGTPDLTFANPFANPFLAPPLPPPGPDNDKKPSQKPFQPTADDQACAKMWSIYIREVERYDKALVEGWKGDMEGMVIFSALYSASATAFLIESYKTLQSDPAQDTVFLLSKISQQLSNSTVPPSELPSFETPVSAIICNVLWFLSLVLALTCSLLAIFVQQWTRDFIHKTNLRPSPIRQARVFAYMYFGLHDFGMDSFVDIIPFLLHLSLFLFFGGLVAFLSPVNRIITYIMIGILSVFLVIYTTVTVIPLVWLDAPYRMPLSGALWRLGNAFGGFLTRKHGLYRQDETLTEGLLEKSLQGTSERDKRALVFTMQSLTDDGELLPMIEAIQDVLYYDNPKFPYYDCIRRANVDLIMPLITTDDPELNIISRITQYLKRSQVVPQDSLKHSPKDSPKNSSKNSLLHGQGSMLPVYSLVYTLMYMLVTTPRQATNKSQMLNEQHVQTHLTFTEDLLLYIAGLSGDHKSLSSTLALLRFRWMSCIWDVVALISRILDEMKKANGQNIPASALQAQISHLNKIWESLDESRMNKGILNSYTPLHTFIDYHKLPRTLKVAGEALKKWGMSVECSTAVPEELEAALDKLKQDDTWDVTRSTILFEYLQQVLTREHRSNQTSISELPHDFEHIWDIICPPHPSLYLVDLPMELGDNYIFPLETLSRWLLDQSTAIDNKVDLWMEKYMQLFFSIKDAQSNLDPAIWGRNLFLRYFSRRAKETVAKPLPHDSGWIRHFINQPDSRRLVGECVIQNIRHETTPESLTCEAAFLFSLLFQIFSPSALSELWKILDDSDKTSSTQNTDISFLRITLSLINIYQTSWHSRFGDEELQSMEVTLLKQYLSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFE2</accession>
    <name>A0A8H5FFE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFE2"/>
    <dbReference type="OrthoDB" id="1715602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="54"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5334557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="178" mass="20406" checksum="55B6ECE3BD6D9200" modified="2022-01-19" version="1">MAPRPEPPVPQHLQTTDKKRKACFTCCVEGEFKHNRFDDLPALKPPKAGELGDELDRYLSADVEATDDVLGWWYGRKKDFPTLYRMGLDYLTIPTTSTDVERVFSRGRFLLPYVRNRLSADTTRALMCLRQWSLMGLIQDEDVMTVAKLPEIEVSDQNAEDIEMPEGYDDIVDVLSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIV8</accession>
    <name>A0A8H5FIV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIV8"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5338429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="354" mass="38294" checksum="9D4D8D9D837BE701" modified="2022-01-19" version="1">MHTHTLRQATKTYIIHFPFLLRAPKSLFVSSLSRNITCTAKIMSDKPITAYQNSVNLPPQSQSLPGLDDNMSPPAEHSKVECWDNDGKPYLKEYQGSGKLNGKKAIITGGDSGIGRSVAIFFAREGADVTLVYLPEEQTDAESARDVIKSTSPHHTTPLLIPTDLSSPDSFQKIIDTHLQHWGGQLDILVNNASKQIMCKKVEDLDPENVESTFRTNILQMIHLTKVAVPYMKRGSSIINTTSVTAYKGSTTMLDYSSTKGAIVTFTRSLSLQLAPRGIRVNGIAPGPVYTPLQPASRPEDNMEGWTVGGTPLHGRAAQPAELGEAYVFLAGPGGNYITGSVVHVNAGQHVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNC6</accession>
    <name>A0A8H5FNC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000154">
        <property type="protein sequence ID" value="KAF5342867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNC6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="303" mass="33104" checksum="771C3B235615904A" modified="2022-01-19" version="1">MADAEPTPQAVPIYFQCAKIISLEPGEVIIVRSSNGQGSTVIHAPLYTPPSSLYDIPSNTKPGFAYIVTRWPPTDPTLVPPPCHRYVWEPNTSSSPPSSPSLSSESSFAPTATSVAPTGTQVQLDATMQRERTPALAGPSSDVPPAYNTVVPRRMPDGRVWVYCAWNHVPSAADLAAYWPHEMYQRCILVTEGCRVGVFPDWTIARVFVERVSNAKYKAYKHFSDALQEYSLALEAVPPRSSPRVTSVPATADRSLVDFDDPSLTGDIEIAKDSHTRIFIFPRGSPESSKLIGAIDISDTEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP37</accession>
    <name>A0A8H5FP37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP37"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="112" mass="11791" checksum="3BA4544854B4F580" modified="2022-01-19" version="1">MVVDVGCRFMVTPSFTHLFIHLLHVPASYLKTAGTSPSPSTSRPTYRSLSVVGEGLGAGVDSLGSSGHLGLKYVATLAHILTPSYTDLLIPSDSRGEIDTKIASGYPEICQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ27</accession>
    <name>A0A8H5FQ27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000121">
        <property type="protein sequence ID" value="KAF5344652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ27"/>
    <dbReference type="OrthoDB" id="3269232at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="534" mass="60051" checksum="7B1FD752583AA92C" modified="2022-01-19" version="1">MTVDAVGKDEGEVEQLEPTPINKDCIYGADESGFNEDDGAKIRVIGARSKKMQHKQGGGSRENTTVIVTICADRTAIRPTVIFKGKDFQVNWNQDNPMKATLGHSEKGWTDGEIGVAWIKDFHEQTKEKAGGHTCLLLPLKQYWREVKEKLFQEKHQQIKKSNFLVVYGEAHLQALTAKNIEAAFAKTGVWPYNPNIVTKDMMASSKETSSTGSLPVPEPSPVHTVSTLMQAMQKRQAENSPPSTPSARRNTRRPRLKDPETPTRRRQIDPDEDIFMMPIQDGINNLQKTSTSFLVSDTPIDAATAVLPHMPTFQFSPMKPDLNAALLKTPPSTEREEILLLELRKIMRKYNSLKETAISLQSSLVLNSVYCDTLHERLAAQEEMKKHISKARLMGDGMPKLLTSEEFVNRVEEFMRESEEKAKQLQDKQASKEEIAAARREWSALCAARKKENEWLHAMWVTDKALWREEKSKGICTRPEPKWGSIKLGPVPKPVILERASKKKSSISGQGPEDNEEEGQISGSDHGSEELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQJ8</accession>
    <name>A0A8H5FQJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_013641</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQJ8"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034331515" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5345461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="232" mass="24490" checksum="7B111E1BC99423E3" modified="2022-01-19" version="1">MLSPSSIFVAALSVASVFAVPTNSTEGAAFGLVERSGTPPSQGTSNGFFYSWWTDGAAQATYTNGGGGQYSLTWSGNNGNLVGGKGWNPGSASRVIHYSGTYQPSGNSYLSVYGWTRNPLIEYYVVESYGSFNPSSAASKKGSVTCDGASYDILQTTRVNQPSIDGTQTFQQFWSVRNPKKNPGGSISGTVTTSCHFNAWRSVGMNLGTEFNYQIVATEGFQSSGSSSITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW85</accession>
    <name>A0A8H5FW85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW85"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="231"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="423" mass="47705" checksum="7D5407C9E4F6B33A" modified="2022-01-19" version="1">MRSQDPAKDCIPVSEVPIMCLWARSDSDGPQPPPDELLLLCSSLLNLPLPSLSGLLRIMVLTVTTNFDLTLGALEIAMNVSAALLGCLTVQTYAYFQSFPKDRLSIRILMFLIWGLEVASHITGSRLVYTLTVTDWGKLLKLLTEHPAELTATFYLCSAVTPMVETFYLFRIYRFAGPRVIIAVFIALFVVWARYGAWLFLSVQVLRLGILDGKFLAKWSWLMILQLSLGAFMDALIAITIVFFLRRRTFEEVDGPSKLVTRVVRWTIQTGAIASAAFLTTLTTFITLKNTFVWLALLAILSKIFSNCFVASLNGRKQLQKLTTPSRNNESYSLSPTTVANWYESWRRDSRGVTSQDVEMQIKSQQSATTLRSPTIANNDISDAERGKVLDPIILITREVISEYQEFERYTPEEENYLTGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX63</accession>
    <name>A0A8H5FX63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX63"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="205" mass="23268" checksum="36F8C167627FF117" modified="2022-01-19" version="1">MALGLELPEETFVKLHEFDAVGETHVRFLKYHPRPDEDEEKTRGVWLSKGHTDLGTVTLLYSQAVSALQVLGVDGRWRWVKHVDNALIVNAGDGMEFLSGGYYRATVHRVVQPPQDQRNLPRLSIVYLGLANDDVKLAPLVDSPVLQRIGVKEYGRFNSGAEIPTMEMWRKARTSTYGQNELKVSEKDKNVEEEIINGVLLRHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FY61</accession>
    <name>A0A8H5FY61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FY61"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="42127" checksum="35DD5F0E3EC64EBA" modified="2022-01-19" version="1">MHGGIQDFTAKGIYNVLSAICDLTAAIPVRMPSLTSVTLDFYPSDRYIPPIAPLLRSLPQLSKIALPSFTDVSPILLALKSSTKLQRLCFNSGTPYNKAVEETWRQLGDSIFTAVEDLYIRVRQYSSIYPFFQEHPLQNLRVLTVLTIQNEEPSSVRNLFQIIPTFSPNLVELKVSYSHESEFFEISVTPPEDEIVTFADFRAVLACPNITRFTLLHAYPLGLTDSDVEEIAIAWPRLRTLRLCNEGYLRRHWRLSSKPTLHALFTLIRHCPELEEVGLFMDTKPLSSATLASLANTDTEFAMLKKLFLQGSPPERQDTYRLAMSLSQFCHPSCTLEWMEWNFTVDEEMTHSWRMVEEMLAASTVPPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZB7</accession>
    <name>A0A8H5FZB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_006026</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZB7"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="110"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5355255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="36557" checksum="FCF04E8C86447980" modified="2022-01-19" version="1">MLSRLSTGAFRKAGSMAASRSTFLPSAKVRFASSSSSSSNAFESFMNSSATLASVSLFTAGTIAWYTHLYGTLPFLGEVHASHLSDEGLHPPHYPWPHGGFFDSFDHARQVIRRGYQVYREVCAACHSLDRIAWRNLVGVSHTVDETRAMAEEVEYQDGPNDEGEMFMRPGKLSDYMPGPYPNEEAARAGNAGALPPDLSLIVKARHGGADYIFALLTGYIDPPAGVEIREGMNYNPFFPGGAISMARVLFDGLVEYDDGTPATTAQMAKDVVTFLNWAAEPEHDERKKTGIKAVILFSTLFALSLYTKRFKWTPIKNRKILYNPPTDKTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1F0</accession>
    <name>A0A8H5G1F0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1F0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="67" mass="7135" checksum="694BD7964EBDD1E7" modified="2022-01-19" version="1">MPKLLSHFVQQEAMPPVVFLALCREEDITNGAAIGADGWAGCTPPATTFKSLLDYETSNTQPVGSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1F6</accession>
    <name>A0A8H5G1F6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1F6"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="85"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5356546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="34814" checksum="EF53E43307274546" modified="2022-01-19" version="1">MPSDIDPTISSTLYGKDLAQCIENFPPFNNTPVTYTQPPNPGWKFGQRVEETEEGKKWVQGEKEGWRRIDVDKESTTAIYQLMLSGIQPRPIAFVSSVSESGVENVAPFSFFNAVTADPPLISYCANTFGGSRFKDSAENATKEFTVNIISVPWAEQANFASVDVPSDLSEWELAGLTKMKSTYVKAPRVKESAFSMECELYHAFEIVRPQTKQITGTVIYGLIKCIHVRNDVLMDAKALEESGHRAKIVADPGKLRTIARMGDISYGYVSEPFRLPRCSWKKDGEAVKDAVEGYRTEKGLPEKEHTEVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5N5</accession>
    <name>A0A8H5G5N5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5N5"/>
    <dbReference type="OrthoDB" id="3265169at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="744"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="920" mass="99439" checksum="42349DCEBF6B83F5" modified="2022-01-19" version="1">MALAGWNVGHDTFEDPYVDMPTLVDSGGRNGVIPPPANALYEGRGGGRGGGGGGIHFEEPSTPLRVRKHSRASAPGLSPAASFHPPTPVHWNGPGTDAHATVMQQNHALNSTFNSFPNFPSTTGGPAPGFGTPHTPYMPTPFMGPYSMFPGAGYNGSGNPFPGAGAGAGPFGGQGYPQGGGGGFTPGSAPGPGGLNGFPGFGGGGGGGGGGGGGGLFANHREYDHREGRGPPPASAPAAMGHQRSRSRSRGRGDGWGHNNGGGADGWGSNWGNGGGGGGGGGGNWGNNNDRDPWNNGQRDEYGWGNGGDDGWGAAASGRGGGGGDGWGGGGGGGGDGWGVGGGGGDGWGVGGGGGGGGDDWGGGGPAASSWFGQQEHQPREGGYRHQRRNGHHSHDRGRRGHSAGWTDDDDWVHYDHGNGYGYDEYEDEYNRAGVPREQLEEIRRREREEYVMKLRRKEAERDRQEQETAKRWRAEQEAGGVRGRGGGFDFEAMDGNSYPVVDDPDRDRERGRSRTRTKESRKEEKRRQRAMDEAYLDDLDLSALSLDDFEHADADLEHDRLRRQQHKKSKSKSKHITSIMVQRANSRGEGIRLGFREPSDQQAAYEAAFERAKMARAFAYQKQMEADRKHVKYNRPMTWRSDYSVRGGIMAKMRKYPSQVEELPPDPIKRSLHPYLQFHGADYEPVISMDLRMSPRDTITSGPAVRLNLNLTGGRSGEPEPSRYGGPVTGVYFLSIPHLGRDPSQNDLMQPACNPPVQFMRLYHPRLPWYVDVSSQLQPGGPVLLSDIISFLYTSLQQQVGEMEYWCEEVDDDPREWERDVRRAASKSRGREAMDDSYGIGRRFIGKAWRDRCNLVGMVNGDEPLGDESRAAGNAGLREREEMGRGVKRVDWLGAEGRTRFIGLARGKNGYWEIKTERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5S2</accession>
    <name>A0A8H5G5S2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="116"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="387"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5358917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1557" mass="170979" checksum="B5F28DB24A35B6AC" modified="2022-01-19" version="1">MDSRTKECRTSSGPIMMKLPRITVNVNLDLDPVLVHCLPMRSHLKLPTTKTLRRAQCCSTTARLSLLSKASSTSKCNAGILSGSSPTLGRAQYHASVLPSLISTSSPDFIAKSQAMDEMVADFEAKTAQARSGGGSKAAERMRSKGKKLPRERLALLLDPHTPFLELSALAAHEVYGELIPGAGLITGIGRISGRECMVIVNDATVKGGSYYPLTVKKQLRAQEIAREHGLPCVYIVESGGAALPHQANVFPDKEHFGRIFYNMAQMSALGIPQIASIHGISVAGGAYVPAMADENIIVQNQGRIFLAGPPLVKAATGEEIDDESLGGGLMHSTESGVTDHLARDDEHALAITRGIVEDLGKAGYQPGLPSKAPEDPLYSTSELHGIVGTDVRQPFDMRDVIARIVDGSRFREYKKEYGPTIVTGFANVHGYEVGIIANNGILFSPSALKASQFIMLCSQRRIPLLFLVNVTGYMVGSKAEKGGIAKDGAKMVRSVACADVPKLTVIVGGSFGAGNYGMSGRAYSPRFLWMWPNAKISVMGSGQLSQVMTSVSKDPAQHATLKSEIENQSTAMYSTARLWDDGIIKPTDTRDVVGLGLALAARTRPSWSTGSTTWDGDGKGFGSSIRALESVSSARRLATPATAGFAARTTLNYYFFMSPIERLDDYTRTKLRSTQILTSLPQVVSELFQNSLDAGARNIEIGVNCEEWMFWVRDDGHGFSKDGLAALAKGSEDGRYRTSKAYSPDSLNVLSTFGFRGEALSSAADLCCLEICSRSTRSRETWSIILKEGQTLYSGPAVRWRRESHGTTVCVRDAFYNLPVRRRSHPSPSRTIELIRQEIEQYALVFPEVSFSFEDTRARDNVILKHFSDVFHFGCLPSSLWQSVMPGKLNIEDVNITSGDMNLQGFISLEGSVSKAYQFLYINRHPTAFSELHRIIDSRFASSTFAKNAFEESGDIPRSAVRRSPRKTEKKSVYVLNLTIAAHQVDNLLEPSKSSVHFQNKNAVSSFLSSAIQSFLTRHGFSTRAPDSRESPSPHKRKRRKTEEVIDDSGYAEYEGVNEEELSPANWNLQMSGGEVAMAEPLCIGGGKGQAEIDGERGDITWTDPNTGEVFIVDARTGNSRPRMLPHPADEAENVMDQPKTQGRRILPRTMNSNAGEAPSWIVEALEANDAYAASEKKIPALTVSSTTNGEETFQKLVGHHDTPHNCAHALLNHFNQHRQRRHQEQKYSRVLLGHRGGTGDSNGLSQHCFTKRDIANARVISQVDKKFVACLIDERPEQNEDSGDTELEQGDSFTSVLVLIDQHAADERIRVEHFLKDLCLGFLRSAEQGEGNVETRQLIVATPVLLTQHEAMRLANSMEIQDAFRKWGFRFSDLDKIAKITNLSVTKLERENMYGDSCDSAYIQVMVSSIPEMVADKLLLGNELRDLVKGYLAQVESDIVDMSLSRVRKSPSESEIQGGDHESFEWLKALRWCPQELLDLVNSKACRGAIMFNDTLTEEQCERLVKQLSDTAFPFQCAHGRPSLVPLANIGLPSKGGRVRKPPILWSALSEPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G623</accession>
    <name>A0A8H5G623_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G623"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5359067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61611" checksum="56514D3930763BC2" modified="2022-01-19" version="1">MSISNPYFFGIVLFSVICYYWIAKTVNRRARFPPGPKRLPLIGSLLNTLPERIGLRAPNPNPTPIYQQFLKLGKECNSDIIHIDVLGDHTVVLNSAKAVTELLDHRGLNYSGRPAMPMLDDLMGWGWDFGHMGYSDRWRRHRKTFTHHFQPQAIREYHSFQRKSVTDLLNKLLTTPEPDVFELKGWIQHYASSVILRATYGIASPKDKEYYVELAQRAVTPILHAGIHGTYLVDYFPLLKYVPSWFPGAGFKRKAKVWAQYSHDLREKPWETVQSEMNEGTALPCFVTRNLGSIDLEAPASDLKQEIEVIKNCAGVAYIAGSDTSISLIRCVIVALLIHPEVQERAQAELDSVLGTESNARLPNYSDREDLPYLNAIISETLRFYPITPLAVPHQSLEDDVYEGYHIPKGSTILGNCWAILHDEQVYPDPMTYDPSRFMKSKGATSEEEIPPQPDAALYGFGFGRRICPGRWLALDTTWLIIACILATCTIKKPLDSNGKEIVPVIEYEDGLVVHLKPYKCRFVPRSEEAVKLMKDGFLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G854</accession>
    <name>A0A8H5G854_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G854"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5360015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44446" checksum="FF761FDA61C0D3A8" modified="2022-01-19" version="1">MDPLAGMDDSSTDDDNTSQTTEDDPQVPEHDPPPPPAQPAPPPSSQQPSRVQRPNYQLQHTLIGHTKSISAVKFSPDGTLLASCGAENTVKIWSPFTGELVRNLTGHTEGLSDIAWSTDSVYLASASDDKTIRIWEVDTGVTQKTLKGHSKWVFCLNYNHNSTLLVSGACDGDIRIWDTKKGGVLIHTINRRCLKTLHAHIDYVTAVHFNRDSSLIVSCSLDGQIQIWNTTNGQCLKTIVEGHDAIWYVVSRCFFESPVDLTTSPRPRISAFLIAQTYSQHVQFSPNSKYILSTAHDSAIRLWDYQTTRCLKTYTGHVNKKYCICACFSVTGGKWIVAGSEDHKVWLWDLQTREVVQVLEGHSDVVVAVATHPSKNMIASGSIDSDLAIRIWEDRTGTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G886</accession>
    <name>A0A8H5G886_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_007556</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G886"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5360076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61152" checksum="AA282E0DAF6FF7E1" modified="2022-01-19" version="1">MIDYFFPNGFPPTMWSSALAFVGLVLGILCLRYISGDNYPYPPGPKGFWYIGLPSSKVPSKKFWLTYIEWGKKYGDLIHFSRFGKHYVVINSLQAARDILDKQARVTSDRPHARVDELYSSSLLDALVLTAAIPYSDKWRKARKLFHQNLRAEATVQFHPIQSQKIRSFVEGLVLSEEALKNQISTLSQKIMFLSIYGLDISNNKEDMPARTRETVESVDDRIIPGLDGYKYIPFFHLLPSWFPGGRHIAAVHAVGEIISEAANNPWDAVQQQIKSDGHHASLIAKLLSETDPDDKEEMDRIKYFGFQSIAAAADTTMSAISTFFLAMSLYPDVQSKGQEELDAILGKGRMPTFDDRPSLPYIEAIFREVMRWHPALPMGLCHDSIQDIAYNGYYIPKGTSIYVNIWAITHDPSVYKDPDQFIPERHLHKDGNINSILAYGFGRRVCVGRYMANDTIWLTIAATLAAVKISSLPNENVEDYYSDGGFCSPNTLPFMTRKVESAPPTFTPLSPLPTAYSTPSASASASTSAQPLSRIPYPLSPIPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHL2</accession>
    <name>A0A8H5GHL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHL2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="13111" checksum="C9BF4870B5D4A416" modified="2022-01-19" version="1">MGMVGLEWEGTGNTGTETDADEDTESWTFSTPTRESDKGINEDDNGDRDRSNLKVGVRIRNRNRIGFWEGSEYDYDHVLVGVTRAVEFNRAVHGYLFIRLFVFQWVGSQGLKIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIL1</accession>
    <name>A0A8H5GIL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BNA4</name>
        <name evidence="13" type="ORF">D9758_003230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIL1"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5365592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="489" mass="55593" checksum="0ACE456756E0F829" modified="2022-01-19" version="1">MSHRRKAVVVGAGPVGCLAAIMLSNHGWKVELYEGRPDIRLPSSKAASQQRSINLAISHRGIAAIQSVDPNAAQRFMQSVIPMRGRMIHHVDGRLDSQIYDRDGQCINSIDRTLLNEDLLQEASSSPNIRVFFEHKVQGVDFDKRVMNIRDVSQSCELDVSFDLIIGADGSYSTVRRQMMRVLRMDYQQEYIRHEYIELRMPADRDKEGRLSFALDANHLHIWPRKSFMLIALPNQDYTFTCTLFAPSSELDRLDSPDKFVNWFGTYFQDALLAIGEQNLIKDFTHNPRSPLICTRSNPYHYKDRGIVLGDAAHSMVPFYGQGLNCGLEDVRILNVLLKQEQVSPTKTGNEADDLRLSRALSRYSQERHKDLIAIADLAMANYVEMRHLVTTPLYIIRKAFDNVLYSLTRGCTTSLAEHCGTLSGVEYAEGEPRGWVPLYTMVTFRPDVSYDTVRRTAEWQKRIVEAVGVTTLMCVAGVIWGLRRSKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJF9</accession>
    <name>A0A8H5GJF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJF9"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="33746" checksum="1F510610B9FC1256" modified="2022-01-19" version="1">MPPMPAGASTTTIKRIHREVADLKKEDMGAITLAPSEDNLFLWKGTIPGPEGSVYEGGVFNVEVQLSGDYPFTSPKVVFKTRIYHMNISDRGDICIDILKHNWSPALSLFKVMLSLSSLLTDPNPKDPLVSGIANQYITNRKLHDNTARQWTELYAKPKPPSSQSQNNTKSKGKQKATGSEGISASTNAAGGSRHTTVVVETITIDDDSDEETDTGKKKSRAPNGAGAGKKRKRESPAASSGRATRGSSSASVDVEDAEDDEDGDEIEVFDVAVASAASSSRKEASKPRGGTKGRRTAPRLDEDDEVIVIEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJI4</accession>
    <name>A0A8H5GJI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septum-promoting GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJI4"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24520" checksum="9F13DE1D9DFFE015" modified="2022-01-19" version="1">MSHSASSSISLTASGSNSQNALENGDEKNSSVVIKVGMVGDSQIGKTSLMVKYVEGSFDEDYIQTLGVNFMEKTISVRRTTITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLSRKSTLNSVKEWYRQARGFNKTAIPFLIGTKFDQFATFPRDEQEEITKQAKRFAKAMHASLIFCSTSASINVQKIFKIVLAKAFDLKCVIPEIEGVGEPVLIYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK58</accession>
    <name>A0A8H5GK58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK58"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9327" checksum="F797284C9CE76A21" modified="2022-01-19" version="1">MPKQITDIKKFLEISKRKDARQARIKKTAAKIAGGKTQTKFKLRCSRYLYTLSLDDPEKADKLKASLPPGLNVVEVGKAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKE8</accession>
    <name>A0A8H5GKE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKE8"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="572"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5366552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="650" mass="69567" checksum="146877E149DE7983" modified="2022-01-19" version="1">MSALPPSPTSSSSRSPSPNTVSPVLRKNPTDPNAKWLVQKFGGTSVGKFPAKIARDVVSPYIKDHRVAIVCSARSGSTKALGTTNLLLRAASEALMRRPQSPQMNSPSSSGTMTPLTFGLFGQIKDIPPRSPPHTPLRSRSSSADEKSGLCMTPLSPLTVPIAGQSEPKFNATVDLIREQHIKAANEAIHNPEIRNELEEEIERDCDWLRGFLFASQVVDEVSPRSKDSIIGLGEKLACKLMTAVLRDQGIDAEYVSLENIVPDVEQEIYSSVGGNVTLDQGFYDRVAAAVGERVRACGYFSPIPGSLLLQVGRGYTDLLSALLAVGLSTSDGATLLDTGTLKYNARVDWDVSELQIWKEVDGIFTADPRKVPTARVLEKISPDEAAELTYYGSEVVHPFTMEQVIRRKIPIRIKNVENPSGCGTLICPDSELSESPSPVSPVSKPFSTHSRTGSVSEQLSALALSGSESPRKLPTAVTIKEHIIVINVNSNRKSVSHGFLAGIFGVLDRYGVVVDLISTSEVHVSMAIEDTFVASGGGGSGGGGKTLDRVIRELRSSGTVSVHRNMAILSLVGKNMRHLVGIAGLMFTTLGKGNVNIEMISQGASEINISCVIDSQDAVKALNLIHQSCLRVPASYSANSTNRGESCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLA5</accession>
    <name>A0A8H5GLA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLA5"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="122"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5366810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="607" mass="65640" checksum="C777885F4C73DD9C" modified="2022-01-19" version="1">MAPLSVNVKHAGKTLPVQLDLELPPGAFKESIYQVTGIPVDRMKVMVKGGVLKDDSNWTKIAPKAGQTFMVVGTAGELPKPPEQPVVFLEGVFATGVTRPSPNTVHSDMDDEELAGALERPVGLVNLGNTCYMNATVQTLRSIPELQISLGVPPSNASLPTSPSSPLPLALRNLYTNMTRTTDAINPSAFLNVLRQVNPQFAERDRSGKMAAMGMMAAFSQQDAEECYSTILNGLREVDVPDALVPPSAASAGRKRFIDQYLMGEIRRELSSPEAPEEAPSVSTERIMKIECNISSTTNYMHSGITGALNSTLEKMSPTLGRTATYTQTSRLTRLPAYLTVHMVRFAWKADVQKKAKIMRKVKFPNTYDALDLVTPELKAKLLPASRRLLEFEKERAERRKVRKRTKNVASSSGSSAAAAAIASGDSTTTPAEVEGAVRSEPVAGELEEESVYREKERVELEALADPEVKADVGASWSGLYELVAIITHKGAAADAGHYMGFVKKNVFSSPPPTLYTGPTASSSSTSNPSSAPTNNANSDSDAMDTDQPAPSTSGKQTDPYAYEDDEDWYKFDDEKVSIFPKEKLSTLDGGGEDSSAYVLLYKSKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLT1</accession>
    <name>A0A8H5GLT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLT1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="148" mass="16804" checksum="DF71B50C8AF1E889" modified="2022-01-19" version="1">MSVYFYEPTYNWDRFFDEAFRANNNQGQPKPQASDVQRFLKPKMDLHEDSERNLVTAAFEFPGVKKEDVSIDVHNGRMTVSAESKISEEHDHDGYAVKERRYGKFSRTLQLPQGISDEQIKASMADGVLTVTFPKASQEAGPKKVAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLY2</accession>
    <name>A0A8H5GLY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLY2"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5367423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="734" mass="82489" checksum="2A169276A4D213E4" modified="2022-01-19" version="1">MDSVTTPLTASSQFIQADDDDEFDEDNMPGFSHPAMSGQSPRTPTVDKGKTRSREPEQLAPPSNGGPAGLSGNIGSGGAPRSARQSVGGIQVETRYTGVDTLDEPVSTTIMRDLLSIYSKLVQVLYPRKSSGREVLKDWDLWGPFILCLLLGIMLSINAPSTQSLNVFTSVIVICSLGALTITVQAKLLGGRVSFFQGLCVIGYCIAPLDIAAFISCFVRRIYIRAPVALLAWAWCIWAAVNFLDGTRIEPQRILLAVYPLLSKSALGLWHCKEWFYPSLRKDLLEVNKFFYEISMDLRYRQVQLQTLSPTTLKIISRLSDPHVGKRVRHLTVSPDFRHYDYSTPAQERRTTIRNRISSALHFSFRIPEPVVRPEHEATKALIDVLPGLTDVSSFTIDSHSWGPHSGPDINRFLQTSWSAFSSNLTKLSLRGHAASFHTIIYSRPDFPLLRELFFELVVNPHPDDSQVGGAEILLGDVVPFINSFAPRLEALTMWCWGAYDLSEFFKRLGEFPLLSVFNFQAAFSRTLETDPSGLTSFIEKHCSRLEHIVLRLKPVPIGLNSAADEPLGRWMKQCFTSVQLSRLRELQMYPSIYADGMDALISCLQQTSDTLTNLVVRDLYLDHVQVEGIVNLISPNLRYLRLNVRTMNVELFDVLSRLTSLESLSLYIGTVTPTFSIDIESRRYKDWKLENIAVWHSGYQLEKRLMYSISTALPFIETYWGRGSALEIAEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM30</accession>
    <name>A0A8H5GM30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM30"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="36003" checksum="C42DA60CF4A7B8BC" modified="2022-01-19" version="1">MHTKNLAGNIILTKTRIKERKRSLSRLPMKRDIYDRHGEEGLKAHEGGQHQGNPFDIFSNFFGGGFAARDQVRRGPTSLTEFEVELADMYKGGSIDFMIKKRILCDHCRGSGAASDGDIHTCSGCGGSGVKVVKQQIFPGMFAQSQVTCNDCGGRGKTIHRKCPHCQGNKVVDHTAHYTLEITPGMPEGHEVVFEGEGDESPDWEAGDVILRVRSRRNKGGWRRKESSLYWRETIGVDEALLGFDRNLTHLDGHIVRLVRKGVTQPGFVQTVEGEGMPLPENENLHGDLFIEYNVVLPLDISPQTRRKLTEAFRPSEAGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GND1</accession>
    <name>A0A8H5GND1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GND1"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="140" mass="14998" checksum="1ED38ADF172F2357" modified="2022-01-19" version="1">MDIAEFHAAVYNMVRQIPPAKVTSYGHIAKLVGMPNHSRHVGQALKFVGSDVDPPIPWYRVISASGAISSRGPGTNGAQLQREALEAEGVEVTAGRTDELRVDLRTFGWFPTAVELPATQDAQADNPNDDANTEGDVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPH8</accession>
    <name>A0A8H5GPH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPH8"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77858" checksum="D844F9BDAC66D9E8" modified="2022-01-19" version="1">MANEVSENSVRIALLNLLAARAASNSRFITTSNGRISFPLDNDDDDEDMDSDSVYNDDDREWQDEDDLLHNPYRSARENQKIWIPPASTPQEAGVELIKSGDFGRVSPKIRARRGHNNLAKVISNRLSRPHPVLYKEDYAANIVPNSHGVVVANYDSNIYTAQFSRDSSFFYTCSQDFRLNLFDTTAPPKFGLQSRPHRDYGYELQTTMKLTRSIQGHHGRWTITDANLSPNNERIVYSSITSTAYMCSTTDDDPTQIPIPFHDSFRNSNDFWHTGSGSFALYSCRFSADGNEIIAGGRGEIFVYDLLANRRSVKISAHEDDVNSCTWADTASGNVLVSASDDTFLKVWDRRSLGASQKPSGVLVGHTEGITYVSAKGDGRYVLSNGKDQAMRLWDLRKMRSSAEFDTFSDKVYGVSNFDYRYPNYPRPKHRAHPQDCSVMTYRGHSVLMTLIRCHFSPAETTGGQYVYSGSSDGRVHIWSLDGTVVDVLDRKKSLPIHQDYTGPEYERKSAPNRETHYTQNENTSSNRHRRPVLSPYPNAFSHPLPKFIFSKETGEISVHFSCDPSYPPSSSPPSDAWREKSYLLASIPKRKPKGKIGRAFSVFSSSSSQSTLDDMAQSGIELGDDEILDEDRGEEGEVDDSTDLLRDVRMLTIADKKNSDKHLLEKARNRRKWQIIQLRSMNARTGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQP2</accession>
    <name>A0A8H5GQP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQP2"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="588" mass="66431" checksum="9BD8B292B09FAB0C" modified="2022-01-19" version="1">MPCLQRQPSMEWKKPFTESVAAFKARKYGKALKLLDQALERGGSQQYIVYDSRAAAHEKLGNTKEALLDIKKTIQLAPNRWQSYARAARLFRQVSMWEKALSMVDIALKKIPSNSDSDSPHRAELVILKEELVNSQKQSICHLAKLPVELLMEMFTLLVGEDFINVLLLSRICQHWRRITLNNPSFWDTLVLSKRRPGLKSLWWLQRSRGKIRELRLRASLNGSGWSFEDLKALRWEYLRICHVEDMDIVAQLKKLSKLHVLSQLEEYSLQDTALGDSWRPLVDLGPLLQRLRLENVRTNLADVPAHITSLTSLTLCNTSNQHHDCLYSVIASNPLLEHLTIDNIQFTTWEQNPPLTLSHLTSLELLRHSQMAFETIKLLSLPRLRNVVLQLCGAHAELFVKLFVDREYKELVEFTSEGNIVRASLFLQLLANNPSLESLTIKRTPGVAEPVLKALASPELCPNLHHLDLSYCPDVQTGPLLDLIKSRNPVITPSVPDNSSSSNTIATGSSSGRPPPSNRTESEASTQSSPLPAISAAAALVAPIERIKSLTVNGCPKVEPEFIPWFQKRVEKFSCKYSTKAEAAWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTL3</accession>
    <name>A0A8H5GTL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peroxidase</fullName>
            <ecNumber evidence="18">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_002111</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="18"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTL3"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="6 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034616804" description="Peroxidase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="20">
        <location>
            <begin position="69"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="41"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5370754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="377" mass="39737" checksum="55762D58B587BFE0" modified="2022-01-19" version="1">MFSKRLSCLVFALSSVRVAYGAHTRPVACADGVHTASNAACCALFPIVDLLESDLFDGGECGEEVHESLRLTFHDAIGFSPTKGGGGADGSIIVFDEIETLFHANGGIDEIVDAQRQFMQDNNVTLSPGDFIQLAGAVGVSNCPGAPRLNFFMGRPPPKAASPDGLIPEPFDTVDAILARFADAGFSMPEVIALLASHSVAASDHVDATIPGTPFDSTPGIFDSQFFIETQLRGVLFPGSVFALEVILKHLTDVHSTGGNQGEVESPLRGEIRLQSDSELARDSKTACEWQSFVGNQAKLQSAFKAAMLKMSILGHRQSDLIDCSEVIPVPRPLVGSPHLPAGNKMNDIEQACATAPFPSLTADPGPATSVPPVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUE2</accession>
    <name>A0A8H5GUE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUE2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034809388" evidence="2">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="227" mass="21753" checksum="12A7F278F43B4EB9" modified="2022-01-19" version="1">MLLKYSILPFFLSLVMSVAAAPMPGKFNGALMARASQTTGGANSTATDIGTGGTGGANAAATDVTATTTDASGANATVTDVIVTTTDVAATTTDVLDANATTTDVAATTTDVLDANATTTDVAATTTNVLDANATITDITATATDASGAATATVTVTVTVTDAVGGAQATAGSANPPADPAGVANQTGLPPAATGGPGDPGDLAALIDSINNEILGLGNSNARRALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUJ8</accession>
    <name>A0A8H5GUJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUJ8"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="535" mass="50901" checksum="64909B43FF0AF86A" modified="2022-01-19" version="1">MAASGSLCPSFASKAGTSRGLFRTYNIPAAASSTSTPASTSVFGQPSTTATSAFGGGGGGGTTSVFGQPSNPTNPTSVFGQPSNPTNSTSVFGQPSNSNPNPTSAFGSTGATTTTSNVFGKPSFGQPAFGQTGFGGTPTTSTNTNNTTTPTPTTAFGTPSATSKSAFGTPSTASTSAFGKPSFGQPSTLGNTTNTSSSLIKPTTTGAFGSGSTSAFGSAGAGGTGTGSGGGAFSAFAGKPSVFGAPAGTTGTTTTGASVLGQPAGAGAGKSVFGQPVGGTTSVFGQPASGGTTSDFGQPASGGGSTSVFGQPAGSTATSVFGQPASSLNSNAPTSVFGQPATGSGSTTSVFGQPAPGSAPPPLPLLPLSSAMSNSTSTSNPPSAIHMSASTSGQGPGFGSGSGNAFGSGSGSDNAFGSTSTSTVSPFAASRPSGLGTGLGSSSPFASTSSPFASVRSGSTSSTLGTGPTSPTQPLSFPSPIYRSGTTPYDALLPQGYMDMVPEGAKEVFKAGKFSFGFGSKGGGVPDWVPPLEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW21</accession>
    <name>A0A8H5GW21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW21"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="85" mass="8983" checksum="FA9450A451CECC4A" modified="2022-01-19" version="1">MIYNVVIVPAGTCLIPSSVKSAATPTATISMARAEVDCFSHGPWCGFDSMAMSNVVDHSSIPSRAKSPATISMMVSIPQSHKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWV6</accession>
    <name>A0A8H5GWV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWV6"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034704794" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="562" mass="61962" checksum="0F693809EA1A690B" modified="2022-01-19" version="1">MLLKAVLLASLVSLTVGRDCRILPTDPSWPTKHEWDAFNKSIDGRLVNTVPLASPCHDPTFNQEQCDTIRNNWHIPEFHEPSSSSMMDPIFLNKSCDPFDPRDTPCRIGAYVQYAVNVSAPDHVIKAIHFVKQHNIRFVVRNTGHDYMGRSTGTGALAVWMHHLQDIDWIKTFRSAKYTGSALKVQAGVTGFNLLAEAHNRGVVAVAGECPSVGYVGGFIQGGGYGGLSSVYGMGADQTLEFEVITTQGQFVRASPKENQDLYWALSGGGGGTYGIVWSVTVKTHRDLPVTIASLNFTSDGISQDLYWQAIDAYQAITPNLTDSKLWAFTGYSSSSFSLYPVYGINKTVAEVTASLRPLLNTLDSMGINYTTGADTYGTYLDAYNSGTIFKSLTVGNALFDTRLLPRSLWDSSEKLASLQKIIRGLVDQNRLVFDFTQSATLEVAGHPQNAVHPAWRNSVKYFTMGLPLTDGESFVQSMQQQNQIATDISPLKQLTPGSGSYLNEAALNDPDFKADFYGPNYDRLLQIKDKWDPDQILYGSIAVGGDRWRETDGGRLCKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXN0</accession>
    <name>A0A8H5GXN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXN0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="240" mass="26844" checksum="8EDEB06127D81841" modified="2022-01-19" version="1">MMTSHSVRPSPASSVHLNSSDVLEQLRSPIRPPDAAVQSKEVFRLLRRAEYELEYNCAHALSLQAELDSVNATRNMLEASIVQALSESFQADLDSVNTKRDTLEAYVTACRSIFEFASVHKLPIEILTTIFALCGTNTFRRLWGKDRRKSWERSLCSLYALGSIGLTTAFSAVGAAIVPFIAGAIAQGAWIWSLQPFMIGMLELQFLTWTCVPKKPRIRSHNETNSNPDTNRTQMTRMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYX9</accession>
    <name>A0A8H5GYX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_000844</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYX9"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5373544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="107" mass="12072" checksum="5505F2085CAC6D9F" modified="2022-01-19" version="1">MSSPIPTANIFEENPYEGNPNLTPTQAEVLWEYAKLAQIIKLVCSKTRLLADEPDEMLVARLRSLEKKMGLVLTLFKASVWGVINEQQIVEPSYGYTEQSGETTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZF8</accession>
    <name>A0A8H5GZF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZF8"/>
    <dbReference type="OrthoDB" id="2675946at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="427"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123517" checksum="13B77F0437F8D3A2" modified="2022-01-19" version="1">MSGSPTTRWLFSPTLISSASRSTQSSGISEASTQTVSLKPTTDDNGNLETAEEYAARLINVFNTKKLLREVCKKLELQSSHNENLEGLKLKIVKKWYPDWLPPPPLSSKAARKPRTVKRLVNASSASSLGSTQSIPAPGLSPQPLQNPSTDSTPVRSKSNSRKQKRNSNAVESSPGSEYADVDEERLLQDLSGNVELTNEDFHAVLGVSRDDSDSEDDEDGADDNGYTDDEDCDDESDHERYRKRVRINADTAFQGHRRLGGKQAQAQIVRSFNKFLDESLFAGKILDRIVDEHSLLLFIDWTFDRPKLSSRGIELPGTHVGAGQIRKMFFGALRIRKSQEAENPHLSLTRPAVTVRVYDLLKTRISQAWERLRNGSIDNMDMPDIVSNTFLDKISDEQMNDVNWAFLKHRETRRAIVGHAAWTCQNASGNRGDDLRALRLRELQPWDTVHPTQGIPMNGMVGLQGEQKVKKHSMVSVNNPVYTAFINHRDPEWCPMVSLALLMHWLFDVYDIITKQKIDWTVNKSWGLIRLIFGDDPTVTYNPHNLYNLFSHTFKSVGLESRMKLHLPRHMLGYRQQNMGVDPSQTAKLGWNRQGVYQDIYAPSIPKTAVLAAHGFRDYEEYSMPWRQVHVPDQFLRLVMPMAEGILAEGTAAMYQELPESSIFKLPALSDPVIRNWMSTTFKTEYTILKAQAGSNIDLSRIQDAVIRESITGTNSRISQMTTQLTALSSILDRRTAHFSPTKGMGWSTETYYNRYSSALPGSSSSPAAVYLPLPELPSLTLAPSTPYNPYLSLPTPDTSISPSSDPSLTQLHQSPTSSSLPLAVVASPHLNSTTTPMYSSPTSSSLPLSVVTSPHLNSTATPICSSPTLTPAPNPPKLSTLTPARNQSTGNLELVLPDLPAFLKPGQSGEVFPAIFGQQVVLWSDVLEAIKRPEHVWDKWGTRGLDQYKTVWGIWEAYNKGEKVFNDEGQPIKKRKSWERFREIPTWIENRLKDGMTLEVVVSNLERMRTDAVQGKGKGKMSLNMLSKHIHKLNSTEAARKNAEAALVTPTSTTPPGSPSRPSDAPYANNTLDGSLIEPKKKKPRERPVFVRPRAKKYKPHVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1F0</accession>
    <name>A0A8H5H1F0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1F0"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="54"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="498" mass="55144" checksum="E3CFE9A7F6F97663" modified="2022-01-19" version="1">MFLDLDLIVRNAVVVTASDQFPTDIGVKNGKIKILAAGIPSQEGCREIDAEGGFVTPGGVDSHVHIAQSAAKGLGARSADDWTSGTKSALAGGTTTILAFAVQARGTSLIDAVNEYHKKSDDHSVCDYGYHLIVTDPNEVQMHTELPKLVKEGISSMKVYMTYVDLKLNDGEILNVLMAARKYKVTTMVHCENAEVIDWMTTNLQERGMTEPWHHGTSRPPIVESEATNRALALAELMDTPMLIVHVSAPEAVNIIRRAQTRLLPIYAETCPHYATLDGSEMRKDDFEGAKCVCAPPLRDDPKDKERIWEGLSNGTFTVFSSDHAPTCFDDDRGKKLGLIRNPTNNPRGNFRTIPNGLPGVETRTPLLWSEGVLKGRITPQRFVELNSTNAAKLYGMYPQKGTIQPGSDADLIIWRPGHKRSQYKIENSKLHHACDYTPYEGMMLEDWPRYTILRGQVVYDGETNEVLAQPGSGKFLQRGSSTLPGPRNQWLSEWRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1G9</accession>
    <name>A0A8H5H1G9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_000196</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1G9"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5374951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="118" mass="12808" checksum="364FE094D3310D19" modified="2022-01-19" version="1">MFRLAARTAPVFSRACRVSRTTTQLPLRAAYSAPAGLSKDNIESRVLDVLKGFEKVDQSKLTTSASFSKDLGLDSLDAVEVVMAVEEEFAIEIPDAEADEIQTVQQAIDYVSKTPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1N8</accession>
    <name>A0A8H5H1N8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1N8"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5375108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="506" mass="55026" checksum="A40E6A65C74CEE0B" modified="2022-01-19" version="1">MAAPSSTTLWATASKEWVIQPKPKPGRKPKKDPAAVTQSPVEDPDGKGRRVQNRAAQRAFRERKQSQLVELQARLQSYEQGEIERNVALQNIAKRLKEENEVLRRENNLLRERIAAMEKEQQGSRENRKKRWRDDSPSSSVASVAMPRKRSRADSDAQDSLLSHIPPIFSSASPPSMVSSPDSNASSDVPFSPIPMDARASSHIPGIIDLSNAAKSDTFSTHSVFREFGCGFCTEGTPCVCREAFQGTVDPMVPTLKVESFEQPQPPTLIRIGSPSPPSVLDNLPTYQPPVPLRRKAASTTSQIFPTTAIQSKPSCSGDPSNCLACADDSFGKAFCAALGRSVAAQASTCPCPPDFSTDPTVVSLDSSDQSQRDNETIPTDDAWRQLKSHPNVAFSDLALLADVVARRTKCTGPTVVIEPAPGTVTPERMHSPTVPNTISGESGAVLLTDPHAHFREKEQARSTESPPRLVPQEVLVKCGQSMVREVQTAGVRDALRLLDSKFSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1R9</accession>
    <name>A0A8H5H1R9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1R9"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 32 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="83056" checksum="B67396D6303D8D5A" modified="2022-01-19" version="1">MPSHSPQKLHSRRLSNGLPQYSFAAQEKRPRQQPAFSWLVPVIITLPGRQPRTLKCWVINPFALARCGRKRACLLMTCLVLFALYFTFALTQRFGTKEKRWPRPPFVGHPPTLVFRRDDLAKIWLWEIASGHYPSRQPIPLELGLKFIPDNPSLPPRKRPPLAIAYEASPNSLPTNGFGPKRIYLDIQSEYDNIAYPPRPVSGSIADFDIVMEHCDFSQRKFVRDCLEVLRNGAGLDNGKRLRRGNMDDWKYIFLEANGTKPAPIAPREIVSEGSLTSSYFESPDSSGLTKKPGAPWEPPLMLSTSVPVRSHSRLSTPCDADYPRVFHMFWAGPFTDKPYMALLSFLYTQNCGLHDHDSHEHACRPQFWMWINPGPAASVPNPSATEDMFNELKSNPWASPFLHPRFKNVIRFKLWNTTEQLDGIPELKDEWRSLETLFNSGGRVINVPNKDSHAVSPKESDTETARLSMRHEHDDPIHRTGSKSSASYDRLSVILSDMARFILCHRFGGIYLDADTIILRDWEEVWGWKGAFAYRWSRLERYNTAVLHLNKGSALGTFLFRTALKNDLDFHPITVSRYLKEAYLEGLLLRLPDALFDPAWLNTEYLQRDRPLSLTFQKFFDTPMANSAAPQALGFDGFFKGAYSYHFHNFWWKPFDPSRNWPDLGPRFEAGELKAKSSPKVKASLEEGDRRDLDWSTVLKRTFESYIRGERPNMYGEWIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1V8</accession>
    <name>A0A8H5H1V8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1V8"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="134"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="500"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5375207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="91529" checksum="AC34161A76338ABD" modified="2022-01-19" version="1">MSRSSLDSIIPARSFTNRPAPISVRHPRVIRADDSRSIDPACLPAQHPSSSPPTPRTRRTSSSATRSHHPPPAPPPSSPVSFPVPSYLDYSALRHLLRTDVSPTFGLAPSVSRTRRAYSPSSDSDEESSNLSPPPREMSIGQAVSPDQPLQLPTRWDAEACHNHLSISDNGRELTFQGTNSNGSDSNAAAARTIQPIPPACGIYYYEVKIQSKGQKAYISIGFAGPDVRTSRLPGWEPNSWGYHGDDGCSFATEKKGTAFGPTYGTDDIIGCGIDFTTHRAFYTKNGSFLGYVFENVGKIPNTGALIPLYPAIGLQHTGESIKVNFGHEPFRFDIDLHVAQQSNQTWERIMSTPLSGRALRGVVGAATGTVGSASAGMSGTRVGAGTEKEQVGDSMATSTSDLDSQTKLTLNKLVISYLAHHGYVKTARTFQKGIQMHDDSAGSASGTGTGDIEMAEASASGASTSAAAGASGSTSGPGSSRGSGSPDLGFDFDFDFEKDISIRTRIVDSVLKGDIDTALEETGKYYPRVFEEDNDADEDGDGDGDGDGSGDVSKRTGRTGRAGGMGMVVVAAEDGAGDRKAQQGLMLVKLRCRKFVEMVLEAAEMKRKMGALDDAQSHSQPHSHSHSHGHSAHDGIFEEDGMDMDVDDDGDPHPGSAMNGVGAATNGGMSSTSTSTSTIPHPSSTSSYHSTSTSSPFPTSTSASSSTHISTIPRHQSQSQTQPSTSTITTATAAVPTTPTTPVVPTKSAYESALQRAISYGQSLDADYRKDSRASVQSIFRKSFSVLAFYDPLEAGGTVGEVAGHEARVELAGELNKAILKSQGRPTRPTLETIYRHTSACIHYLGVEGVGAAAFADMQKEFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H258</accession>
    <name>A0A8H5H258_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H258"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="997" mass="109254" checksum="B53C1ED252897164" modified="2022-01-19" version="1">MSSTHGRDDPDPELEEAFFQFDPFEPLSSSALPSSLRSVEPEAPYKAVTITHDDSISHSTYDMMHPRTDILGKGKAVSRPVPILIAQVDHTEFDDFGSPTWSASSSYHNDPGTPGISSTPSSPSFTLGSFSSVWQASETASVDGFTDAAERSSGKGKGRDTDVPSIPPLTFSPSGFEPMQSGESSISYTHASPSSNAPFHEPLVSSSTGISASPTLRSPMRPAPSRRHSYTASPTHTKRHSITSRFKGKLTSSNKLPGDIARRLLSRKLASPPRVAGAIAASPSIGHQPPILDPFPVSFHEELSPSQDFLSASDDAVFAQTFLKAKGRSNSSPLPLSALDFIPSSSEDVFVPVPLVFRNYFDELLPREIQLQVLTSLVALHEGEHLRQLCRGSWTVMKAASSRNRWVGKEKAVCELVKLSRVSKTWRDLVFDGQLWNDLCLRVLPSMRPSQVLAISDIGGRFATSLNLSGHVHLDHNILSSITDKLSLPNPSLSLAAPPFTQLTTVNLRGCISLTTQALHHLLVRSPALERLYLKGLSVVTNTICDILAMYCPRITVLDLSRCPNMDAEGIRRLASAFTARGECLKLKELRLAALKNVDDKMMMKLGEAAPFLEVLDLSYSRKLHNSALDAFVACEGLEEQRGAIDTETVQLAANELGRDPSDSNRYRRRVTQLRHLSLSSCALLTDQGCSNLAHSVPRLELLELAGIGEELRDDGLVRLLNTTPLIRKLDLEEAYEITDSVLAAITPSTAEDLAAVPDPLVPTKKTKKAAEPGHALEHLVISYASNLTDEALSNVVRRCPRLTVLEADNTRIGASVLREFVSLSTSRKLINPKIVAVDCRLIHDSLVRELTPTTRPRMGLRTWDTRKLRYLDGRDFGAASPNLQEDDDSGKDDYRDAIMKVAHGQDELDEKRVVLKTFYSWQSVDAVWAARDKRRKSSTRRKLNESSGSTETESEELGGGRTRWWSPGGRRSRPGSGSNSPPAFPELNLDGQCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGX2</accession>
    <name>A0A8H5LGX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1437" mass="162806" checksum="13461F892FB3F308" modified="2022-01-19" version="1">MPPKMTGKCEHCNEPLDTDNPRSVETHYRYCDGHKESLKNIASSGIRKVVRKNFKKVTSTSTSSTSPRVIEDSSKSQPMDPINNDPGAANLFPDPDPESIAISNKLGSNPEELLPRPCRTVRIPVPQPDPEAVVDLEVASAASNTPAPLPSLPSASFAPTQHTTELDQFHVFRIYQTLPGRYPNISESDRLGDAPTFSVADEANQYLANAHLKLAQEEDSGEEEENGTDWFAPFENPSAFRLSNWYTEANGNLSLAHVDHLVANVLKKKDFDVADLDNFHAAKEIGRLDQPKNGDTNSIFSSHVWSESSVNIHLPHAGSIGGEENAPTLEIKGIHRRSFVEVIRTAFIDVGFLKFSLSGFQEFWRPTPDSSPDRLYSEVFTADEYLETEHELFKQQQDHLSSLSDSGSDSEQGAPSSSSGSGQGAPSSPSDSKSGSESVSSNSKSGSEFTSSNSESGSESTSSNSTSGSESVSSSSDNEPSYPSYKHPKPTPPHNNPSSPIPWLMVPIMIYSDATRVNTFGNTSLWPVYVYFLGLSKYSRPKPSSGAAHHFAYIPSLPNIQEMYQKHFKATASSEVLTHLKRELMQAIWFLLLDTEFVKACIHGILVLCADNIWRRLFPRIFIYSADYPEKMLLACLKTLGRCPCPRCEIEKKDISQMGTFRDMNRRHSKARTDSHPLRWNVQEARRRIFEKGKAVGSRSVQVLLEPLSQVPTNNAFSAFFQKLLNTSQNYFDLFAVDLMHEFELGVFKALFEHLVRIAYSLGDEVIADINKQFKKCPPFGRCTIRRFTDDTTSMKRIAARDYEDILQCCPSVFCQLFPPEIDHHTQDLLFAMATWHALAKLRLHSETTLKILEGATHELGIQLRTFKKQVCDSMQTVETPKERTKRERREALEAEWKKQVAEGIQQGEKELRCEDVPEKKSKGKKKHMEDKGVEKAKKAKGKRKRDEKDSRSGNEGKAKKKEKNKGVEKAKKAKGKRKRDEKDSGSADEGKAKKKEKKRHRKIQKNFNLFTYKIHALADYAPTICRKGTTDNYSTQIGEQEHRLVKIFYVRTNRRNFVFQISKQNAHKHCSEAIAQREFRWIKKKTPLMKETDSDPLPLTNPNKPYHISESQRYPITIDQFMQNHHNDEAVQGFGLRLHNFILTSLGHPEDPLTFTPVDRNLIIIQDNKMYEHKILRTNFITYDRRQDQDFINPHTRSDVMVLAKQDEQEQHPYWYCRVLGIFHVNVLSKRDPIGTPAKLIEFLWVRWYTLDTSYAPKNRLPRLSFIDSADPNAFGFIHPKNVIRAVHLIPHFARKTTKSLLSVSIAQRNDEADKDWRYYDINIFADRDIFMRYTGLGVGHIGTYKATGAFRDEVVRKYVKAMADMEDEDMDTPQESQADEAEMAVASDEEGILGVQGIIGVEEEVTSDEEGDEEEGDENEEGANDEVEHIGYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLC0</accession>
    <name>A0A8H5LLC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLC0"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="246" mass="27399" checksum="4ABA92878113E5A9" modified="2022-01-19" version="1">MPSSQYSSKRDANFCFPIPNALENDTIEIVPFIPSKHVEEFFSSSQDEKVWQYLPIGPFASPSEFASYWEKHIVSSDQHTLFVILDKTTLKEDGKSPYMAGMIGYMNSKAVDLVTEIAFVIVFPKFQQSHVASNAVGLLMHYALDLPENGGLGLRRVQWAAGTKNSASVRLAERMGFKIEGVLKWARILAPAKTIASNGGPERKGDPRAGCPSSDTALLAVYWDNWENGLREKVDQVMGRRIDSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLH7</accession>
    <name>A0A8H5LLH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLH7"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5361494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="568" mass="63709" checksum="38D7A4994B6A718A" modified="2022-01-19" version="1">MAASRLSRVKESLCSWDNIKAAVQVPQDQIVTEGHQWSNHDLDPTPPKERKWTAWVFASFWAAHAANASAWTAGSATVALGLTWWQAWLALNVSHIIGTFMIVANGRMAARYHIGFPVCARSSWGMWGSYVAVIMRAIVCVIWNGVNTFYAGRLVDVCLQCIWPQWTNVPNTIPEDAGITTRQMVCFIIAWFVFQCFTLVHPRDLKWFYLVKSIIVFIAMHGILGWWMHKNGGVHFAHESDTGISSTTRAWLWMQAFNAGFGTVSSLTVNQADIARYARRPADQFWGQVLMYPLASALPGLYGILVASASRELFGEPLWNLWDVTQTMLDQYPDNRGARFGVFLAAGSMALALIAVNLSTNCLPFGSDVTALWPKYMTIKRGQFICCLLGLAIVPWKILKDGTTFLAFLTGYGYWLAPGAAILCVDYYFIQRGNIITKELYNGTPQGNYWYHGGWNVRAPIVTVLSLIPCLPGFASSISTAVNVSLDAKRLNNISFLLTYCITAAMYYYSYWIWPLSSSMQERIGGQRFEKFADELDTEEREKELGDLERKTSASNCSDEKEATVYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LN42</accession>
    <name>A0A8H5LN42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LN42"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="45011" checksum="D15F82862568EA94" modified="2022-01-19" version="1">MSSFETKYQSQGLEELSVLFTPIQLGPLTIRNKFFMAPLTRDRNVPTNVPTDLMVEHYRQRAKGGAGLIIAEATVISQQGAPWPHAPGIWSDEHVRAWKEITDAVHEEGAYIYSQLWHLGRISHIDAPEQVASGEPVYAPSAVGARPNGLSKFRFLPGKPGPSTPVEIKDPRRFIEQFRLAAINAKRAGFDGVEVHTGGGYLIHQFLDNTTNKRNDEWGGSVENRARFGLEVLKAVTEIFGPGRVGIKLTPAGGYNDIGMPLEDTLETFTYFITKADKLDLAYMMFLRYNETMDEAYDGKTRGTPHDVIQTYKPLVLNTKFFTNQSYTVQEAAQHISSGKVDGVFLGTAWIANPDLPKRIQFGIPLNTNIDMGRLYGPKDGSVLSEDELTKGYTDYPFAELPLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPQ3</accession>
    <name>A0A8H5LPQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPQ3"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034517332" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="26281" checksum="457758E4E2D66C24" modified="2022-01-19" version="1">MFTTMHALFSIPELLCIIFQMLKKEDQRQCIVVCKIWSEVSLDLLWADVRDVKRLLNILAPVKMKYGEDIKYIFDSPPDHIQWTRFQTKYSHRIRSLRHYEDQKIPSLMDILTSFHASYSSPILPNLRKLHWYWFSVDPTLQMATTFIHRDIQCYHTDIGWQYHSPKEVHAHVAAIPDCMPALTALFLDGNPFPEYTETIVRILRALPYLTQLELPAYSANIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ00</accession>
    <name>A0A8H5LQ00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ00"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="122"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="441" mass="49777" checksum="3173D7C088E3D409" modified="2022-01-19" version="1">MRIPSQTRKSLSTRRLGCAVKAGWRLEVRYFQKPIFVHNTQSHLVSTDGYQAKMTSQAVDGLRTDHPDDLWLCTSLPITPAGSKPADFPDCWAECFVSARAKRAVLNTPGFPEPLPRPTSPDCFRLEESPGRGICMFATRDIRWGDLVLAERPLIVTPRAWRPTGPIPKQFTPKQRQQALNMQIEKLLEFLMTRLPEESQAAFKALSNCHKEDGSGPLGGIVRTNVFRIDDYYESQSPGEPDDARFYGGTFKILSRVNHSCSTNADRSWDSPTFSLQLRAARDIKKGEEITLSYIDGLLKPASDRQRRLRSYGFQCTCQACVNAKSSDARRKKILQYLETKPNGSKVFDLILEGKKLMDEEGLQSYVAYSEMLSRLVALTRGRATVKPDEGEKEWKMLETFRLVRRGGRNAETRPRADNDAKLQMVQQMIAALAVGQEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR07</accession>
    <name>A0A8H5LR07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR07"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68518" checksum="A9E78BC40A5B1366" modified="2022-01-19" version="1">MSDSLTVWYLHYEELGFRKIVVNCKATCNDLQQAIAADAYSKEHSTRMNIWRPQTPLSGLATPNELRARFNPSKSVEQSCTRVDLSMLVCDLLESRYEPPEDGCIPVVSLLDKVFTEVSEHAGFLVSAFHQSVLRAENERLPRPCACTQSRSGRDTNGRDFSMITTPIELYHPAFPQFLQDVETNGLSPSPGKLADTVVLMRSIEAVSDPSSSRKTSTTMDHLLAILGISRGFVSNDSDSSPSPSSVILYPSTPRRSALAAIVLEGLKFGSSNDPTLEVFYVYKKLWAQPERRRLLQSSSSPTLLITLTGPWLCVYGAVWTTKPIIQRLTDMIWLGISPLLNENKVSRIACTLLAAREGIKTLERFYQDLGLCSLVMNDKHPRFFPSVTSYPDPERPGKHIKFEYVEPMEKEALHMCVTYRARAISSPDSVVPDFTPQHPRDIVVKFARTYGEDAHRLLASHGMAPNLLYRGPLSPNSELSMVVMDYFPGQTLNLVFGPMEVCNEVYQEAKKALDVLHDAGFVFGDLKRPNILVLGGRHERDEDERSQGTSRKSRVALIDFDWAGKIGTARYPAFLNPRATYPEGVGPYEEIRKEHDERMLESLRRPIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRJ4</accession>
    <name>A0A8H5LRJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRJ4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="451" mass="50625" checksum="ACDE7D0E6D0B487A" modified="2022-01-19" version="1">MSLPKLWSRMEIQVEKVTDVSYEGIRCMEYFSKLFLQRSGDAHLDLVLAFPSRNTEKGYYGNGYVKMNASMLKPIIGVFYSQSQRWQHFSLSAYDSFFHPNPLLPWVESLPSIMSMKFDAIDNTYDPWNGYRPLPIFKRLSAPSLRTLTLGGLASGWLVDAPRDIPASPFECLQSLVISPDCLPGTALLRLASVSTSVTLENFNDCEYPDSTITCLAGALCVNPFFTEGTGFQLEEILRSISLPNVTRFSFGAGVSTASRYKWDPVQLVRFPTDQFLSLLHRCSADQITHLTINHYSFGNPDIAVMILPRLPSLTHLEVDESPKDWECHPFQQRPFKPTLTSSFFEALVIHTPISDHTLVPQLREASFSSQPFLNMTQNIGEVVANMLETRWRGGQSGLTRAKFSGFRSLLDMDEGSAGSIIKRLREEGMSLELGSFLDLGRSLVTLVQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSH0</accession>
    <name>A0A8H5LSH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSH0"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="12668" checksum="B67A30C24764E4ED" modified="2022-01-19" version="1">MGYCKSSFPSSANSTQFRRLCRDKPMRPGYPLFFEASGLRNEPPFPSHLPPILFILSFILSAILSFAVGVMLIVALWEVMRGKTSVEAQDNDVYRKVALSRGEMFGNGYDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU36</accession>
    <name>A0A8H5LU36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA ligase (ATP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU36"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="479"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="637"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="98767" checksum="A4D002FA5FD56F16" modified="2022-01-19" version="1">MSAANPNILSHPLAKSEDSDLIASLHALATQKNRKLVKSTVYPAPADPSIEVRSWKMTEHRYYDVPSPFPTLARGIFSVEIPQEEKDGKQRDPKYRIVARGYDKFFNIGEVPWNTWESLEAHTVAPYILSLKSNGCIIFIGALTPSKLLITSKHAIGSVKDQNGNDQENQAEEDEGDGQEEGVVAPGTKSHADAGEAWVRKYLKTKGKTEADFAKVLWDNNWTAIAELCDDSFEEHVLPYPPHLTGLHLHGINSCTKVFSTLPQDAVDRFAEEWGFIRTLSTVCNSIEEVKEFTEKVGMDQVWEGQAVEGFVVRTHIGSPPPEAEDDKGGNAGMDRRGRHGKNPYSPGSTFFFKVKFDEPYMMYRDWREVTKALLSLRSKQPSAFSAASANSLHKNKMKRPETRVYVKWVIGEIKRDPGSFADFGKGRGIIATREKFFKWVEETEEGKAEMAKERGKRDVIEKVATSTNEQEQKFDKTIIVPIAIPGCGKTTLAVALAHIFGFGHTQSDDVLVKKAAPVFIKNVMDLLKKHDVVIADKNNHLRQHRSSLREAAAKLSPPKHVRLLALSYPVASLPHSTLIRICGDRVVERGDNHQTLRADKTGAKSHEQIVWGFIGSFEELSMDEVDDVIEVDLEWSMEEAVRYSVEQLSRILELPKPSNEKVKEGLSVALGYKPTTFKPDTEEKTKEAVEIKYFALMPEVDIGALLQKIFEEGVVKEQSSFFEQLAKGKRITKRSHVTLVHKNSFSTSDGENQGEEEYAKGLWDRSEALHTMSLPPTFEFKLTNVVWDDRVMTVVVEDLLVQPSSATSDKDQKGAEFLKELPDEVRARLHITVGTENDKIPPVEGKALMERWRKGEQGIYSLKLADGGVKVVGRVKGLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUK9</accession>
    <name>A0A8H5LUK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUK9"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034401221" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="93"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="613"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="661"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="661"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="718"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="718"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="881"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="109450" checksum="F64D06250EB9BB75" modified="2022-01-19" version="1">MLSALLSVLVAVPLVCNAVPPSRIGVKIPLNKRAALTEDGVVNPAALQSQTKRLQAKLRRGFEAYERNTGKPHPNAKNFVSKRDTGADPLTDDDESLWQGGISVASVDFDTGSSDLFLPGTNCDVNCDGHKLYDTGASSTAKDQDDTFLLGFGDGSSVQGEIFTDTVTVAGLTATDQAVGSSTQYSTGFAADEFPPDGLMGMAFPAISEFGANPVFQTLIAQGQVDEPVFAFKLSTSGSELFLGGVNNDLFTGEFTQVPVTQEAFWQVDLDAVNANGNAALTDLGAIIDTGTTLIVGDTNSVAQFYAAVPGAQDASDTIGDGFFTFPCDSVPDVSFTFAGTDFSVSPDTFNLGLVSEGSSDCVGGIVSLPPDSLPGDSLWVLGDVFMTNVYTSFDVGNSQAMVDLALVNPALESNRQHQFALTNHAEILTTELAEIDNLLKSVDSDVSDDEPGMEIEVPGANPPTSIIPWNDFSNEESPFYEEAMRRSRYIRNTTMHTMKARELDALTEGVKAELTRLKAIDNKKKGLPMPSTNDVDLNGDVSNVNWSIVAERVNDVSSAKRTPEELRIKWLGDRRPSINHSEWSASELDQLKELGTNRTPIECMRRGYVRTKHTWSAVADRRLLEAVEIYGLENWGCVALYVSEHATPGQCQMRYTRTLDPALKKGAWSPEEDARLRSAVSILGTSWQDVAAFVPGRNNDQCRERYTDCLSHEEKVWTPEEDTELLTSVARWGLKWKIISQHMQTRDTDCRTRYTQLTKKDGKKEKKAKKASTSGMKSVHVRTDRSGTTPPPTMPIHQIPSFRATLSTSTTTSFRFNAMLDKGKGREAQSVTADSSSTTPGSSSQTPSTAAETSGSTQSRPKPRPKPRKKRKEKERETDSGPTVSDTGAGPSTSTAGVAGVGGSQSPAIEDAQPNVVVVSDQQTTTDALLPPSMQQGHPALPIVNLPSNSAEQVSIDAQNATQPAAKSTIAAASTSRRKRRAEDSPKGSSAPRKRGRTGKGDTAAVPDRRKDGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXC6</accession>
    <name>A0A8H5LXC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXC6"/>
    <dbReference type="OrthoDB" id="2916164at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="22295" checksum="05C1113C8820FBE0" modified="2022-01-19" version="1">MHTKRHPARNFIIIPGTFILILLIQRLFFGGYTSQLQASAPPSILHIEGQWKQVRQALGLPPLQDAVYFSSTTYKPNRSSLGSRFFKLHSGIGLAKRDSDDFQVEPDSSSNPNQETDKADIEPAFTFAPPPTLYFPQDALHEPRLSTEQLLRSFQLIAVKEEHEDRTDMVVVPNSELAATGNRPKTGAARKSGRSGRTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY41</accession>
    <name>A0A8H5LY41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY41"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="38825" checksum="71867911D58FA888" modified="2022-01-19" version="1">MVAITFRLVDDKVSLSQEGYRTIPCYLALFALAEIFELLMAFDALRLRNVIQLIGILLFHLACMVFAAVQVHQTRTALITGTDCDTNADLIKCDVPGSLWRRIEPYLIVAPCVIAGSWLFMLFWIRQLYAEFGWAIFHIVGANPKMKTMYQYYQIMICLLKFDFFFFTAVTMQLLIVVLAQNSTEFGVTISAIPVVLVLLGLCAIAVQREIKWLMSISLVLMLAAETYFIYKLVRFYEPSSRGQYQTTRATLTIFTIVAFLILFATFAVGLRCFADFDRGLQSSKVHGGSYQLVAIKPGQLNGNAILFLDVSQRPKYSTGGSTGNMSEHQSPYNSGNALGPRISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYL2</accession>
    <name>A0A8H5LYL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYL2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="348" mass="38536" checksum="CB3BCC26800F4B69" modified="2022-01-19" version="1">MSSATSSFRNAALRLMSRSSTSDVRNREASSSDKDSVKGSVKDSETASVVSQSQSPPQSQSQTSLTQPQTQTQTQTQTQTEGQTESTPSKADSNSKTKSMPTRPFRRKTLSFSFHSKAPSQGAAPRPSNASSNASSNDSSSTSNTSTSNDSHAVSSVSTAPTSVHSEPEKDQERDVLERRIVELEESLKKAESDKDASVEEMKELRVEVEEMRAALAEKDKTLADTSAMLGEKQSSLAEKDEEVTRLREEKDQAESEVRTLRDVLKTKEDEEESRWKEDKEREAASKAAQEVFEREMNKLKEELVYAVSKIEEEKEERGKVEQILKDKEEEDAKKAAASTGWGLCFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYP6</accession>
    <name>A0A8H5LYP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYP6"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5374274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35784" checksum="338ACAC1F6949411" modified="2022-01-19" version="1">MFDTYSQILSSRADGNSTDSDLLPESPYGYTPNRALSYIFLGAFLIAAVLHLGQAVFSRRWFLLYTVVLSGILEVFGWYGRLWSSREVLKSTPYTIQFVCTVIAPTPLLAANFVIFGRIIRRLGTTYSRLRPRLYTKIFFTSDVIGLFVQAGGGVIASGTNKPKKTVDLGLNIMLAGIIFQMMIIVSFSLLSYKFFQHHSQDKSVRPLGQGETPRGRIEGKIQLLIYALAFNTVLLFLRAIYRTAELADGFGPGKIISIEWLFLVFDALMVLLATVTYNVFHVGRLMESEEVFMLKLKGSNTFNPSSSDVALNGMKLQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYR0</accession>
    <name>A0A8H5LYR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chromatin remodeling factor mit1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="845"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1413"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1445"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1625"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1773" mass="199777" checksum="E30660532803F7B6" modified="2022-01-19" version="1">MDDTDPPDPLLLLSPVTTVQTIDQNPPNSHNRRQLYVSVPSLPEAKKSLYSDMPEEGYVAEPETVIDEIVGDVQDKKKGLHLYYGRRAGELLRGYTENTLRKRHSHLLESYAIKREYGLVPKKFDPSGDDVDPDSRLSIFVSIDKKSKKADYSYRSGSESTFTGSDESSELTDVDDDNFSDGTHRATRRSSRTRRQYTLPFSPKKTRAQRLYLPQDSDVSDDEDASPKSRRRSTRNKKGRVIKFDDGTETQDSDYQISRVKRSKKTKGKKSFSESARPAYGHFRSIEDLEYDSDEETRVLRAHRNFCEKCLEPPATRLLQVALKRTKKGKKKKSEEDDFEDTEDDEERAKSLGGWVQCMKCPVAAHWRCLASTQQNEILKATQIRDRAKWLKEHEGQDVDVAKDGPRKRPGLQCDQTTEFICGSCTKGGLCMGCKQTALEPVPVTAPESNEQGVSEGAASASGGVTEETSPQYKQPAQLLFRCRTCKRLAHYGHLALPDLQEDELLAAERLQHKWLCNDCHSYQWELDKILAWRPYPPNAVEPPHSGTEQINYKSSLPREYLVKWQGRSYRRASWVPHMWLLSTKPSKLKNFLTVGSRIELLGSTSDGVGEFDDQPSNIFDDGDILDSSASRRQTTTTSAPSSMPDAENRIPLDWKTVDRVLSVVLRRPHPRKARNRKEKKRNRNNVIMSDGEEEAVEVDEEAEKVYQATFQNGELPPEDFTETIYSFEARTGRTFGEDPEDIQLIVWAFIKWVDLGYGEATWDSPPLHSDPTYHAFQGAFRRFVASREVRVTKHGKNTVTELDKRTKDEYRRTLTYQDVSQVQLGQDPSLKLMDFQLDGLNWLCDNWWNKQPCILADDMGLGKTVQVSTFIGRVIGEFQAAPALIVVPNSTITNWIREFERWAPKLRVVPFYGESTGRKVIKEFELFHEDVEQGFTRAKFHVLVTTFETMTNTNDFAVFKSQPRWEILVVDEGQRLKSDSSLLFRKLNELNTLHRVIMTGTPLNNTIRELFNLMHFLDPSQWQDLEALDSEYAELNEDLVKQLHGRLRPYLLRRIKNDVLDLPPKNEVILPVSMTKLQKEVYRSILSRNLEILGSLTKPGSEVKGSARKTKITNLLMELRKCLQHPYLCDEAIEPRDLSPQETHGKLIDASAKLRLLKSLLPKLKSRGHRVLLFSQFVIALNIVEDFLVGENYKFLRLDGNTPGFQRQKDIDEFNRPGSDVFVYLLTTRAGGVGINLATADTVIVLDPDFNPHQDMQAIARSHRFGQTKKCLVFKMMVKESAEERIMQMGKKKLALDHLIVQKINDEESVGDTVQSILTYGAQALFESDEGSAKDITYTDNDLDSLIDKTEKEGQVDDKAQKEGFSFAKIWTADKNELEEIGDDDQGQGDSWAQTLQKINAERERVKIQEEALSGRGARRKAAYRKENMYIEDSPVKKNKKSKSQAVSNSDGESAYQGSDINSYGSDVESLPNAMGVELKELQNTGGRQDYSAPSEHRGHKAQVPTPASYCNLCEQYHGDGECSMLESSENLVEYREMLMLHAEDESWENRSAAIQAIDELLYRRGDGHLLAGQPLHLVQGPLLGAKKEKAKIPGQTPVQIPAKTLPAAPRPPPQIQYVAGPSLMTNTAPKTTIPSNGVPRPQAQHDAGRPSLTKNTTPQSVVSNSGLMPRSQAQVQNLAGPSRPTHTAPQTANTSMGVMVPQHPPPAQPVAGTSTSQRLPPPHGSKRPSSPASLPQAPNKRPKKAEDTCAVCKGPLHNLGQCPVIAQGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B1B4</accession>
    <name>A0A8H5B1B4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000502">
        <property type="protein sequence ID" value="KAF5314796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B1B4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5314796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130365" checksum="426E8D62238AC1BD" modified="2022-01-19" version="1">MSISTKSVHSQTSATGPTVVMGQKRKQCPQCGARVKPDRGLTQHNQAKHPAPEPGPQAPLFYFPTPNLRTPSPPLVAQSPPSPVFSSRRSPRRRQNGSPIRLPWSAAPLDLQKYGTRVETHPILDGTPCDPDGYDLPSDTVPAPSPPDEQENDYSPFQNATEFKLAEFLYNKVQMSAGDIDTLATLISELVGPDNSESVPFNNHKELYGLIDAIRQGDIAWESFTVKFNGDLPDDMGSVPAWKQQEFQVWFRDPLAIMEQMLANPTFANQFDSSPKRLFKNGKRLYHDLMTGNWAWFQCDKIAEDENTHGAMFCPVVLGSDKTTVSVATGQNDYYPLYISLGNVHSSVRRAHRNAVALLGFLAVPKTSQDHASSAEFRKFRRQLFHTSLEHVLSHLRPYMTSPRITKCPDGYYRRVIYGLGPYIADYPEQALLACIVQNWCPRCTSPPDNLDSDEGRRSHEHTASLLEGDGCTLKELWDDYGIVGDLRPFTASFPRADIHELLAPDLLHQIIKGTFKDHLVDWVFEYIDMTYSKQEANKRKADIDRCISITTPYAGLRQFHEGRGFKQWTGDDSKGLMKIFLPAIVGHVPHQMVRAIADFMEFCYLVRRSVIDENALDVLDETVARFHRNREVFRSSGVRPEGFSLPRQHSMVHYRHLIQQFGAPNGLCSSITESKHIKAVKRPWRRSSRNQPLGQMLLTNQRLDKLAAYRVDNESQGKLQPLKGYLKTLQDSLPPPPQPAPDDDEDEGAVDEPFSQGDVKLSKRGECLARGVPRELRALAVYVGQSSLPTLIRHFLYNQSHRDAPGGQRGCDVPLDRCPEIADDHPVYLHNSARATFFAPSDMSGLGGMRHERIRTVQSWFGGAARYDCVFMEGDTEEDGFSGLLPDYGRDGSPNLEVVHLDCLYRGAHLIGISGDTRLPATGLAASDSLDAFEAFYLTMTLGKRANESEPPRTPKRQATVVIASSQSPEILVARTPCKSEPHDPNLMLFSVKQEEIEESENNGRTQQRNLEESETEDETQDTDKTEDAVKASKIKKFREEYSKGVGKNCWGSPYLINSGVSKPALLLLLFLRFHNVKTGSLSYQTTYTTPKLRCQALELNLEAASYAVQLAGRDRDRAVERSNELTKEVVALRRELRRLQDGVKSTGWDLLRLADRVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B2G8</accession>
    <name>A0A8H5B2G8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000498">
        <property type="protein sequence ID" value="KAF5314813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B2G8"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5314813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="93" mass="10411" checksum="635F91B8F53A834C" modified="2022-01-19" version="1">MHGITWDGDAEREKVAREWVETSVTELKKTRMVRTRTFRGIDSLKMGQGVPEGPVAQKMPIYLAVYEFLTAKSAESCAKQLAGNANNFSKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRE1</accession>
    <name>A0A8H5BRE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000367">
        <property type="protein sequence ID" value="KAF5328142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRE1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="82" mass="9367" checksum="3908FFC0F0DFD577" modified="2022-01-19" version="1">MSCVSYHHDYYVKNSSTRYYYNGHFSDVLQIGKHQFAEVGLIKLWTYNMNIAWMSASNFANTYTLSHDFSKYHASGIVAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0C6</accession>
    <name>A0A8H5C0C6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_017213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000302">
        <property type="protein sequence ID" value="KAF5332882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0C6"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5332882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="186" mass="20421" checksum="AF4F238B0DEC630A" modified="2022-01-19" version="1">MTFTSSILLTLPTHLYLDRLLIDTITSKPDEEKAMRKLYGEVFTTQTNALYIFTDGSCFDNGTSRARAGAGVSAGHGSDFSCSARVVGDQTNNCDSEYTIHSIAHWAIKNTSTGWKCPNGDILKDIAAWLAYCTALLFITHVKAHNRNTHNKMADQLAKEGAMQPISQSHYIPLLPSTKPNPPPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2N8</accession>
    <name>A0A8H5C2N8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000281">
        <property type="protein sequence ID" value="KAF5333891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2N8"/>
    <dbReference type="OrthoDB" id="3251057at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="699"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="799"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5333891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="840" mass="95158" checksum="83F2CD636A6A72A8" modified="2022-01-19" version="1">MHCLAVIWSPVVHGWTKRKTIFGHSSVFIYNPIPTSLSSTTMSTGTKRKHASSTDESSQKKKKKTKSRSDVDSQPEVSQASTSASAPAATVTKGLSSVRLAFNKRYEGKTMGEILPILTAKFQCPNASNVYNHFHAPTLEMHKGEYSLKFICKTKPSISLRRAPWEDSTGNLRKHINSCDPKEKGSIVELIATQRYDAAKLRFLLAIWVTRRKCPFKMIDDLELHEILTMLYHRVDIPHSTTISRDVKMIHEMAKVKVISELSAYTGRIHFALDGWSSPNHLSILGISLIRYHDRKLQEMTLDFVQLRGSHTGKYLANMFLKVLQDFRIDQKILAVAGDNAENNSTMITHLGTLLGNFDGHKARVRCFAHIMNLVVKAILSVFTGKTKVTELGLDLEKDEQEEEEEEDVNTAEDDELDPDREAFDEEVIEKVNEKMDELAAAHAIKITVGDFKEGKKGMAKVSALSCKNYYNCDFREDLKELAVTQGLKTQHTLSQPVTTRWNTTSEMINGAVEIEECIMDVTNRPAWNKPNGKKLRQLCPEEKEWKVLKDLQEPLDLFLSKTKEYSQSSVALLHNVILDMDSFREALSDVRDDAAKHPAVRYSMVKGIAVLDKYYSLTDDSELYRAVMIMHPKYKAQYFRDKGWEEDWIKTAIQIARQIWQDRYRPVTSPDTSQSKPKNALHAKHFAQGANPIDNAFEKYIKTATQDDIDDPLVYWELQRKNNPHLAQMGLDYCSVPVTSVHTEQSFSSGSAMVSRFHHALSDSSLHSGVVVCSWHDLGFIPMDEVCEKFQQNNKRWKATAQSHERESAATETKGKTNEVVIIDDDDESGSNEGSDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C378</accession>
    <name>A0A8H5C378_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_017431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C378"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034657199" description="Chitin deacetylase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="10">
        <location>
            <begin position="195"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5333841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59835" checksum="78CEC5202E4A39C9" modified="2022-01-19" version="1">MFSVSSLITLSLAAIAFAHAVEPGAKRQTLAQVIPARKEANTIALTFDDGPYIYGPDLVDLLDQNDIKGTFFYNGDNYRCIYDKDMQSNVQYAYSHGHQVSSHTWHHDDLATLTWDQIHDEMWHVKPYGSYNDLVLRASAVRGQKVVIWDFDDGDSTGSPPDESKADYDQLVSEHPNTVIALNHETYVSNVKIISITTGTKCLPMSRYPLHGEALHDSHAEILAQRGAVRWVLDEIIRETEGGYPKSEWISRQPEGGKYALKDGGKLCFDTSTRYLAAFQDPEMAALKNSQHTAAPTSTSSSSISTHSRGRNNYSLYSALRTKPGRADSPPTLCMSCSDKLAMWNVLGIQGALGAEVMKPLYFDEVVVGEVAGDEMRKMVKEDCERAFWGRLDVDWDGARGGFVKEVESLSRHYHLHKPAIYFTDIPFILLVPSYKYHPGYYSKVGMRHFHLTHNWYWRPIINVDKLVPGEENKGLSEEFEVIAVSLIPIHCKRAIRFRDHRVKIKAQIIFFYHYLYLVFLAYVLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C439</accession>
    <name>A0A8H5C439_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000288">
        <property type="protein sequence ID" value="KAF5333758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C439"/>
    <dbReference type="OrthoDB" id="2783256at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="70"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="212" mass="23761" checksum="09883D26C4E365C7" modified="2022-01-19" version="1">MPGKHVRFAAAPTFYPTSSSTSTSSTQEPHRRVPRYTTGYNHKPHPPIPTYSSRTSRIHNLLAYSNHPTLHFDVSLPLNAIAFSSSRPSTRSLSESAIDPPVASMTLSIPHITWPVIVTPSNGVFIMVADVLNAIYSTLRSPITKEEYRAIRSPSDLKRVNAAYERRHERIRDDYAAYRERQGGVRRVDFLAGHTRFLGVSSTGRNFILNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4V7</accession>
    <name>A0A8H5C4V7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000245">
        <property type="protein sequence ID" value="KAF5335252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4V7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5335252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="62" mass="6872" checksum="3D76EAB98BB14DB4" modified="2022-01-19" version="1">MDRTTKRKQLLSPPMLLQLKYKLVFIAVFTVLLSSAAPVIHLSRTSDEFCSDPNSASCSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C542</accession>
    <name>A0A8H5C542_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000242">
        <property type="protein sequence ID" value="KAF5335445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2682806at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1402" mass="160186" checksum="77716E005BCF85D0" modified="2022-01-19" version="1">MKKYKNKEEQRLAANAKSNRYYHRNAQKISIARNTNRNKLALQMAKQETKKRLKRQERLSIRTDSESSKLNSIARVEDIQRSFNIRVNYSPMSYLEQICLKTQEWMVISARDSVCPALSDSFDILIKGANESCKHLEVGDEYTQGARVKRRIEQFVACMEDIAIAGIKGNLKVEYKCSSFKSIRSRWLCHPSFWFLPFMSNSHSASSNSHSASNSEPVYLQQARVVFLEPGEVIVVASRVVHAPPSTLYEVPQDVEPGFTFIATRTPPFDPTIAEPARRYVWTPEEATPPPSPMLSSASSLESEVPESQVPVQLPATRSTQQVSPSDNPPTTDPLTPTSSALSTSHAAYTRADAPPPYVAQIQQPLPEGLVKVYAAWNSHVPTPVEILTYWPRALYEKCYIVLEGCRIGIFPTCQGPSPNRLWRGYQAQDSNPSVSQRPYLHSDSLIDIDVSSQDNPTQGWLPFREEYLEEMLWVEGRRGLGDQCSACSVVNPIYRCVDEECVLAGMMCKKCMISSHATHPLHWIERWSGNRFEPETLKSLGLVIQLGHRPKERCVFYQAAHSDFTVIHTNAIHEVSVRFCGCDDNLSHRTQLLRTLWYPATAADPQTATTFSCLRQFQHLNCQGKLPAYDYYHCLEIMTQSRQRVKPKPRYPAFLRTMFQWRHLKMCKRAGRGHAASGIEGTTQGELGLDCPACPRPDKSLPPDWKEKGELSLFLAIDANFRLRNRVVSSTDKSPILGDGWAYLVNSIPYRKHIEGHVSDTDGLRVSGVGGICCARHRVWRKNGIGDLQKGERYCNIDFIFWSTIDGEDYLVLVISYDISCQWSVNFWERMAKIDKNFKVKFTKTGVRFMVPKFHLRAHKPGCHFKFSFDYAPGCGETHGETIEEGWSQSNKAAGQTKEMGLGTRAMTLDDIFGFANWRTIARLDENIGKRLVVAVKEFDLHEWDFKQFDNSLASTLGREILGEWRDSVLAWENDHSKPCPYEDLEHDEEKGQLKTVQLEMIAEEKAMLEAGTSAFATSPRSLELYILTNKYLTTAQQLEVEKRRSGLLKHITQFRNLQSMLMPRLSDVLSAEEMEHIENPDLSRPEKIRLFLPSECGTASAMRTACVAGLMDNEARLREVEARDALEGVRDGLRARTAANRYKVQNITGQIGNTRASGVLRDIDIRIHSHKIRYQLARDALLSLRGHGKWEETLRPLKDEDVRGLSERALTREEQAQREAIMSRLGVGVDEEWSDGEGLEEVMITSRRGERTRHLSWIWYNLRAEELSEGDPEYREALRVEWCKARARVHRWREELMLLTDELRRMVDYSIWKGEWWMKRVVGQEGMKTSVSAELAEGLNAYAWQQVKYQEERAVQVTDRWYKLRTHADKVLNRIQALPTLFLDFGEDDTDIIKEAEACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5J9</accession>
    <name>A0A8H5C5J9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_017762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000237">
        <property type="protein sequence ID" value="KAF5335642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5J9"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034740077" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="846"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="871"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1054"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5335642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1099" mass="115335" checksum="B2CF3D294F1D1011" modified="2022-01-19" version="1">MLLTLGFGFGLAVSAVSAQSSESGVASTSAVPSSSAVISSVLPPSSSPSAVSASSSPALSISIPTFASASASKLPTVVSSEAPSSASTSALASSVSSSVPSSASASASASSVSSSVPSSASAPPSSPSSDVPFPPLGAPVNRHLVPIVPFNFTPFPIPSHQPISSIFIPTDPLSPPPVFDSSSPTSGTNPPTIPSFQDAWDIAYSKAKSLLSTFTLEEKVNITTGVGWQNGLCVGNIPANEAKGFPGLCLEDSPLGVRFADYVTAFPTALMAASTWNRRLIRERGLAMGREHVGKGVNVALGPMMNMGRVAQGGRNWEGFGADPFLAGEAAYETVLGMQQAGITACAKHFMFNEQEHKRTTTSSFVDSRTTHEIYAHPFLRSVMAGVGSVMCSYNAINSTYACENSPTINALLKSEYGFRGYMMSDWQATLSTFGSVEGGLDMTMPGDITFDSGDSYFGGNLTEYVRNGTIPEERVDDMATRILAAWYLAHQDSPSYPSTNFNAFNIPDEATNERVNVQADHYKIVREIGRAGIVLLKNEKPKQKFPHTNTDLGRPALPLTGRERAVLVAGLDAAPQRGGPNMFSDQGGNEGILAMGWGSGTAQFPYLISPYEALQHRALFNRSIGTLFDWQFDDFTPSALTSLLSQAARKDAALVFINSDSGEQYLSPDGNEGDRKNLTAWHNGDTLVQTVASVNPNTIVIIHSVGPLILEPWIDHPNVTAVLWAGVSGQETGNAITDVLYGDFNPQGRLPYTIAKSQADYDAAAKLMTDGQETPPGSDILSIPYEEGLLIDYRFFDAHNITPRFEFGFGLSYTTFEYSHLSITALPTPNDGDESDREAIRRWEAGKTSLASWPPTPNTVIGGGANVSDTNPTTTTGTGSSGTNSTTGTAGEGSSNSTSTGDAGEEGSSNSTSITGAGTTGTNSTSTDGTNSTSAGNDTNTNTNSTSGLNITLESRDADTSSSTGVSGTSTAPWLHRPAYRVQFTVTNTGSLPGGEIPQLYLSFPASSGEPPRVLKGFANVDDLDVGESKKVSLWLSRHDLSVWDSVPAGEAGKQGGEGVEGLSGGGWKKGARDLGDVKVLVGASSRDVRLRGNIPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C753</accession>
    <name>A0A8H5C753_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peroxidase</fullName>
            <ecNumber evidence="18">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_014766</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="18"/>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C753"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="6 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034520833" description="Peroxidase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="87"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="41"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="61"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="289"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5335227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="39929" checksum="5FA428F85E99C1A7" modified="2022-01-19" version="1">MFSNLLINFVLALGAVRVASAALTRRVACPDGVHTATNAACCALFPLVDKLESDFFDGGECGEEVHESLRLTFHDAIGFSFTKGGGGADGSIMVFEDTEVAFHANREHIIQIISFDMGLISLTEGIDEIVDAQKTFMQENNVTISPGDFIQLAGAVGVSNCPGAPRLDFLMGRPLPRAPSPDLLVPEPFDTVPTILARFADAGFSPAEVVALLASHTIAAADHVDPTIPGTPFDSTPGIFDTQLFIEVQLRGTVFPGTSGNQGEVMSALHGEMRLQSDHLLARDSATNCEWQSFAGNQAKLQTAFKAAMHKLALVGQNVNDMIDCSEVIPVPRPLVGQPHLPAGQTKTDIEQACATAPFPVFAADPGPATSVAPVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C821</accession>
    <name>A0A8H5C821_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C821"/>
    <dbReference type="OrthoDB" id="3252187at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034575906" description="Integrase catalytic domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="322"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5336286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="625" mass="71213" checksum="941EE7EF31281EBC" modified="2022-01-19" version="1">MRLSRISVLGLLCLVLLLFISQNAIASENHESATAGPSNLDQQLTSIGNTNEQEPSAENLVLSFRTYSAEFDHIVRQVLGNPGADTFQLRQLSEDLEEFRLLVHLYGEQVLDQEEYALLVRNIIHMQHDVQQRHDVVLQASHHGRPLLVETVTTNQHGRPRTEINPGFLDFAYRHRSTSGISRFLHVGCRTVRRRLLQLGIAQPGQNPFPSDEVNTMLDGDSEGSGSEDDLLDPQQRVLDDTASSSAPNARSYLSSLSDNELDELIISLRIHYCRAGISMVDGMLRRLGHIVPRERICLSLIRIDPVHQVFSRIQIRRRGYQVPGPNALWHHDGQHGLIRWGIVIHGFIDGYSRLVTGLHASNNNYADTVLHLFLQAAVVYGVPSRLRGDHGTENLHVAAWMEYHNGQRRGSYIWGRYFRSVHNVQIERLWVDVTAQVGQSWHDFFTDLEMHHGLDINNDNHRWLLHYLFLPIINQELSFWAESWNNHRIQIHDGPNRSPIDMFGFDMFMHGFRGHDLNLNQAELEVYGVDWEALRSEGILRSQADNNPSQLHETGDSAFIEQTHPPTNLNFVHVEAPQGIMTPEQLYHLEALVSPWRGGGRLEDLQAQWLTALVCARSLCGNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8N3</accession>
    <name>A0A8H5C8N3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_016282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000223">
        <property type="protein sequence ID" value="KAF5336744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8N3"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="580"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="895"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5336744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1118" mass="126581" checksum="A73219154E32FEBD" modified="2022-01-19" version="1">MYTGELFGYTSDWFRYVIYNDSSYDVTTLGEEDWALAEQRNPFNIATWNGNISSFRDRQGKLIAYHGQADGIITSANSERYYEHVSSTMGLDPSQLNEFWRFFRISGMEQLFRRRRSLDRSWEELEEGMEVAWVEEGVAPERLLGTKFVNDTIRTEGSVALERSHCRVALLDAIILPTSSMSGVRNAGAAFAIPNHMTGNTSFANCYQARGTTGRVANPPSSLTRCSDFQRLSETRKDCHIDDDVDEENVSRKKRRTPRMLAMNVVGEKFDCDYARRVCSSCITWNTACTHTVAKRKRGPKTGNTSNFAAVKSIISSILAEASQPFNIPEDEDSVREILVDIATYVRHLEKELARARRHESWAQHQTSRSTVDAQSTPQSGPSPSSVEEESDYSEGEALSHEIAKVRLTRMQNRHFGKSSSVFLITSAIDIMKYPYYERRWEYYVPSQFERTYVEGKPVYEFPEHDHLQSLVEVYFTHHHPHVPLLHQASFERSVAEGLHLRDHQFGALVLAVCSVASKYSVDSRNLPEDSSVTLALGWRWFQQLKLTRNMFAEPVSLYELQTFCLEISFLRTSFHNEASWLLTGLCIRLAHERGLHRRRDPLEKPTLERELWKRAFWFLSMNDTLWSAFFGRPCASSKDEYDLEPLVEYDDSVWGSPFIDVSTLSTSKTSNSAYWNCLIKLVEILAFCQRTLYSVRKSELIDAMGVPDTQWNEKAATQIDSALNSWTDALPSHLKWDPHCTNTVYIVQSASLHAVFYWIQLHAHRSFIPLLKQGGQLSSTFPSVAICMNAARSCINIIDVLHRRHGHAMLSELPVALMSSAVIIMICIFRSKELQLQIEPQKEMATVFKSVGIMRDWEKTYMTAGRFVDLMHVIMSGGGLQYPIHVQETPESALLKRPREMDPERNPQSTMDPPTNPSRTDTPPEIGRLLAGSNRVPQTIQNPNQHLNFLSESRTPYPATASGFEETSAFQDQRRGMTNSGSSADILTSVSNIASSTTESLDMDAAFFNDLSNGFNSVSNVLGSSPDDWTPALYGTVASDVGGVHQVRDESLDIGSSELQHVVHEEIRPQPINQSLSTFSSGGDLHMMTSSSIGTHQEDWEGFMANIDYFLEYGFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8R0</accession>
    <name>A0A8H5C8R0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000227">
        <property type="protein sequence ID" value="KAF5336631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8R0"/>
    <dbReference type="OrthoDB" id="2496395at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="31803" checksum="2CCF8636009DB234" modified="2022-01-19" version="1">MQRQGSSFFLTLGFRFPAFTIPGRTRFSRVGSHISQQAAVGASNEPMYYCRDIVLNNWLLNLKGKPDCFLEVDLVQEHLNYWIKTIYKAHGSNSSWEWLSMISPCVEVFRKLATNINDSCGEARQGSRHAPPDLSKDIRILMDSLREHGVYKITKGRVFDVDDSLAKDVITEGLCNLSSPLAEYNAAFKRLQRRRRQMPITGGLDPGLEEFVSSDMRESAGDELRVDVKEDVEGVEEVTDLAEDVFEGDIARAIDDEEVQTFTLDNEEDVALDIDVVEVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAP1</accession>
    <name>A0A8H5CAP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAP1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="394"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="782" mass="78471" checksum="B15BB43FF4A5AB59" modified="2022-01-19" version="1">MYTYYQPTTTGQPIYPAAQPIQVQQYPQVVPTQPIAAGQTSAGVNATAATVSGPPATAAPIQTTTTAAPAVGQVNPPPVAPVQPTTTTTAAAPVQPTTVTTIPAVVPPAGTQPAVPNAATNTAAAAVVPEVEVTRSITPRSPTIASTYTSPDSVAPDITVVPAAGGNMGMGMPAAAGGVPGVVPAGAGVGPGVLPGPGYVPYATMPVAGAPVIPGAGIGGVNAVPSGVPIPVPAPAPVASGGVLPTQPSGMGPMGGMGGMGGVVPPIPNGTNMPPQAYYASSGTNQPVVIPGAGGPQVIVIEKSRSSRSGRRHHHHHHGEDGRIHTHSIQGLLLAHISLGLLQTRLSQSGPSARILSSGVLQAAANTSVSKMKSFTVVIAMFALVARSQTIAYNGPISLGRASGKCIKASSNSDNAPVVIGDCNGGSDSQWTYINGNIRIYGNKCLDVPYGSDANGVRLQIYTCYDGNTNQQWQYSDNHIAWTGYGRCLDDTNSNLQNGNPIQLWSCSSSNTNQIWNWQAASSCVAQRAVAAHLTTVITTVAPSPVTITSTVTQAVSTITVTVPATTLTVTRSTSASSTSTATTISWSTTGGITTNTSTTGSTTTSVTGSITSIIPASTTVIGPFTSVIPASTSVIGPHTSVLPASTTVIGPRTTVIPAKTTTLSSFTSVISASATIVPALIISAVVTPAGGNSAVTSFFTLRPEETSVITPVTTTVFSKITSTISAKTSVIPARTSVIPGSTTIIPATTTVVPAKTTVISAVTSVIPARTTVIQAALSAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDJ0</accession>
    <name>A0A8H5CDJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDJ0"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="408"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5339279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="607" mass="70101" checksum="51847791A65D567D" modified="2022-01-19" version="1">MPVSARTAALVAGAYRHFRIPPPSFIDPSCPSSHLERSLRYLDVLSNHLRDATLTDSQKRAVLAEYTRNWPLIWVHVSTMLTHFILEGKPPTTEGIAFRDRLLQLFHDAITFFRFTEPATQRDKPPCLALMEETPELFPLILSVWHQLMDEDHSSLSLMFRSLDVTVTACLLDKALFIRNWECVDLAPNFMWRLRSYIYKQLRSQDQITLLCLEYAFRIPLFFSQDSPTQLLHLFITRETLTCLSWAFKFLTNPHNFLRRGRLAAGFSVQYLKYICLTFYYSSKYHGPSATAPLLRQGLLRSVLQAVEIIAYEEAGSGKDARASPTLAQWLANLFLPLGTYFCYHRVLDPVLQTLKEIARDPSLAQGLHSQPESCPLKKAFDKISTYASEIKELRDEFESEGLIICANPECTQRGIRTGCKFRYQQCSRCQATIYCPRRCQRRDWQVNNHRKKCEEVCQGIGLVKYTLTDVDLQFMEWFALRHIRLHWDSELMIQRSLQQARQENGTTDTSVLIVDYCRSDDTLDCAFISVTAEEYTTRTDNLMKVSCRELRDQGHPEDCPCTVDNMAHASKVKDMQRAGFEVVVHAMFRGGRNSRVEFVFPCPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CF32</accession>
    <name>A0A8H5CF32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CF32"/>
    <dbReference type="OrthoDB" id="3050931at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120474" checksum="CB1274A38A15C57E" modified="2022-01-19" version="1">MSTTTAMMAAGPSIPSVAPSTSTTAVPSSTISISNSDSRSTTNSDTNTSGAGPATATAPNLSTISPSLRARFVEEINRKKPSEEDVTIWNQHCLSMICTYCSNAGHSKCLPAEGIKSVRCRVCNDRRGTCSKVRDELHFRVKRLLEIDDSVFQLLYESTGGASIHAAVKRKGGNNGNGGDDDSPSKSLRKRSSTAAIVDGVLQLEPSKAPTDHRKSKSKSKRKEGSKEDRDGTVSDASSDLSSLCDCDHEQRLSSALEEVKRLKLELASAKSAATSSQSSSSPNLTADLTAAQNELTRTKAAKEEVEKKLGQTTQTLEKVLGQVQPLTQEAVRIKKDNDELRKRLRELEGIKTKYLELAGAAKPSKAADQDPGKEALAKALDRAQKAEEEAEKANTRVIEIQTKTVELEAELTKVTVALGKAEEECKKVTEALGKSEEECKKATIALGKSEEEYQALRDEKAALEEDLGNAKATLEERDEHEQQREQERMEASEGIAEEMQNQNDKLHAMVLLLKGQLSRSTNALKEANGKLAQHAQLQVYGPSLNHEVAELRRKCLELNDTLEKERKAMAGDSVEKQNESVNENENVKENVKENAKEKQNENENENEDVIMNEVEDQDQRKKTPVYGPDTYDTFLTKETLGDESTSSGPSTEQTQSQPQPQPEAESSSQPRSQSQSPTQSQVDPSSHKPDGADSSSSNSTPTTSSPSPTDELSKLKADSATLQSTITSLQITKSELQTDFESLKREHDIHMVAFKTQIKELLTLKTANAELQIKIDRLEEEGSETSTDSLEKLKNAHDEITNLQIEVRSLEKERERWERHREKYERDKEKDSEKVKEMKRVLTEMETKYERSVRDGKEPNRDRDKGKEVDYQHLPRSSGRGTLEDEEDGNSLYSVSSSTQNPAAALQEAKREILKLKDDLEYLRNHRDFLSSKLTARDTEHAVSLQKDVVEHTNLHLLNRMVLQAKADFTSRRITRSQIIDTCDTLSAQLLQVAARRLDKLEGADGERVGFKGIMDLMDTASVVSSGLRWNGVPAHNRSLSSASGSGSAARRELAPERSGGSRRREEDVDSQEEDASEPPLKKRKVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFJ1</accession>
    <name>A0A8H5CFJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000172">
        <property type="protein sequence ID" value="KAF5340821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFJ1"/>
    <dbReference type="OrthoDB" id="3068934at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18278" checksum="5A8CED81DD877D19" modified="2022-01-19" version="1">MQFFLSFEEWKEDAKLNEEGLIMLLKQNLWFGIVQRIYQIDPVPVTYAAWKAAAVRLNLCDQSVQTLRNDSRGIPASGNTSVGTWFTTAQTPTTTTQNATTSAGAPSEAPMTCTGTGVTFGGQGKPMEIDCTKANKWTWDGVRKCYGCGEEEHISRNCLNQVSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGG6</accession>
    <name>A0A8H5CGG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000169">
        <property type="protein sequence ID" value="KAF5341269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGG6"/>
    <dbReference type="OrthoDB" id="3283998at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5341269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="194" mass="22632" checksum="F278D23B1816A65C" modified="2022-01-19" version="1">MENTDRRNSSVLTWGSLKGPEHDDDYYETAERINECLTLKYMEVNEPWTKLPLPYNPSPFYHHNPPRFVYGFGFSWDELIDYAVRKGLSPRREELGFSGLLLAWNDAVRQLNIDCGLADAPFQMQIHTPLLKHADLVLVLWDNHSTEIPFPTFSLSAAKKMIGIWKKEGIPKRPKWWISDDIDLSVTDYRVHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHW6</accession>
    <name>A0A8H5CHW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000166">
        <property type="protein sequence ID" value="KAF5341356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHW6"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034881307" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="96"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="22888" checksum="76FB88104864B79F" modified="2022-01-19" version="1">MVFINAFVLAGVLASAFAAPVAEHQVESRALPSVIATSTARAYLSELTVATESNSPAYDRSLFKTWDIISGTCDTRETVLKRDGTSVVTDRACKATSGEWTSPYDGATTTNPSTFDIDHIVPLKEAWISGARSWTNAQREAFANDLTRPQLVAVSASSNRSKGDRDPASWVPTSTSFVCTYIKAWIQVKHFYDLSVDTDEKSALSSFLASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKE8</accession>
    <name>A0A8H5CKE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKE8"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="2">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="412" mass="45115" checksum="B0D2EC2F4B5636E3" modified="2022-01-19" version="1">MANHTTQTTHPNLSRQLEELQLVKFSLLPGELLVFLEHCRGWEGLLEGYEGPESAGLELQSVHVMVVKEDGQGGVGGERDEIPPVTFQVSLDSWNVWFEVGFPTGYDASGSGSGFSSEEGEGGEGTNGYGKETKTKTTPTISVKGEDITRVEQEEWAQVVRERLGEIGETEYPIYQLLSLHLLPLLHEKAEAAEAAVSESIDSSTLDVEDASVEASRYDEHDIQTSSFSSSPSTRTHTTTPQLYHALLTSHHLISPKKRRSLSSWVSSSSMHPKLAGFAKIGYPGVIYVEGSKEEVEEFVDKVKRMQWLALRVRFLEGLDADTGSLEAPASSQKSTAHAKGKDKETTKNLNKTGTKTGKGNQNQKSQMVGRLEGWKELTKVGEVVDEMRRVGRERWVVEMGIGSGHGLGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKI9</accession>
    <name>A0A8H5CKI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKI9"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="23913" checksum="A68D8256190C90F5" modified="2022-01-19" version="1">MGRESIDEPLVPLQRPTLFLLGINPAYANHDEEFVLKLQEKRLSVSGDDFYINDAAGNPFLHCKGKFFSLRSRMEFYDLRGQLLFIVKRKLMSMHITFEGHTPDESKVLFTVKNSWRTFGSARAKITFTNIDGQETELALRGDFFDRKASVTLGDPEGPLLCRISRSFLNKRYLLTGKDTYYLTIAPGVDAAFMAAICVCLDEKENESCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL24</accession>
    <name>A0A8H5CL24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL24"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="71" mass="7645" checksum="E064D0619F878B4D" modified="2022-01-19" version="1">MYPDMSGMQSPTSTGCLANTLCPALSACLEDGDEWMYKLKPSLWAGSDYRYSLASITSPAASFIHVVFSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL34</accession>
    <name>A0A8H5CL34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000156">
        <property type="protein sequence ID" value="KAF5342788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL34"/>
    <dbReference type="OrthoDB" id="10255174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="622" mass="69495" checksum="449411CDC71F946D" modified="2022-01-19" version="1">MSSQDSVDKPMATDLPDPFIFTGETPLFALIIGIDKYKHNEHNITAHDGIRTHFDNLQGCVADAADIKEFLVQTLKVPAPEDDTVETFDGPNTYIVELLDGKATRGKILEAFQSLIKKTTIGHENPILIYFAGHGGEADAPDWWPGYKGFKIQMRLPYDFDPRSNTDRDSQGILDWELGYWLTELGKKNQDNITVILDSCHSSSGTRRNTVARGIKLEPGYKIHPSALSEEVDFSSLPEAGGRSTKPAKGHEHDGLASHVLLAACSKNNVSYESDHNGKSRGHFTVGLTGILRDVWQDYEKEVTYENLIRRIPDLQWSQQPECEGRYNSRILFTTMEHPVTRTTSSESDISKKIRQRFITDNKLKIIPGDIQLDDDLKRRCKLTLGQEDRPTLVYVDCETGTRVPLSLGPVPFDIKHINPILKRTATFFEALGDSNESDWTKESITIEQMELENRPPSTGGRPPVLTPKSCSRNLMDGNGVFHIPVDIPDKDGGRVSTKYGFKITSTYTKPLYAWIFCFNMSDLGIGTIHQPSVSKGQGDPCLSASNGILTIGYGTGGGTAREYFLRRDVDVDICYLKLFLSEIYEDLFHFGKGPFGRVMGAAPEQFANRSTIIVPIIQERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL70</accession>
    <name>A0A8H5CL70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL70"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34131" checksum="3106209D9EEE51DB" modified="2022-01-19" version="1">MVQNSSGIADTATLRHIITSFLQQCDFADLSQKPADQDLEKLCCLEAAHRGYPLAGEESFQPFISGGLPMAANGYLHLKGTNIPTLIALYTAFLIYLDDVLCNDIEAVAEFNERLMAGKSQKNCMLDHFAALLSEFSAHFPRIVHNIMLSSTMNFVTALLLEKETQGMPMQLGNLGYPTFARALSGASEVFALAVFPSNIPVTTYIQALPELVVFINNGNDILSFYKEECDAESVNRVSQMAQCLGISKHKVLQRLLDEAVSAHQLILRTLSGSKQALHAYESFYHGYLKFYLVLERYRLAELNLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLH6</accession>
    <name>A0A8H5CLH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLH6"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="145"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="343" mass="37097" checksum="12D313B07DF2A45E" modified="2022-01-19" version="1">MAQPEPQPVPSTSGLPSVSPQLSSIDPSLTSQTGSQLPSLPASDVPFDQIPAEVVVNEIPTTQEPFVVQPQPQPAPPQANGQNGHPFDPSGLPTTGFAASNMTSPVTPTVSGWNHTVSTDDRTKTTLVPGYKHVEEFGPNEEYEDEEEVIYMTFDLGNIEPTLIPSSKEYRVIGLDTPNPFLQLSGTILKGRHESLLGTELLFTEVKDDEDPSKRHLSFVSTNEQRVHFKEVTLVPKRPGASSLTSGHNNNGAASTAKGKGKAKEGSVEGSTTGEASDIGMLNRMTGKDQPAKRTRRASTKGKEKEKATPRRSSRKSKGKQKQVEAEDEDGEEHYDAMDVDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLV3</accession>
    <name>A0A8H5CLV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000143">
        <property type="protein sequence ID" value="KAF5343306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLV3"/>
    <dbReference type="OrthoDB" id="2972553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="71295" checksum="46D503CD383BA26F" modified="2022-01-19" version="1">MNTPGGGTSNGRCRPLSSAILNALSVGERQRCSGYSLHTDIFLFILGIANHWQREPPFKPRVPEIISPLRPRVPEFDPQFLWYHVQSQTFPLTPPRDQLLWILKDAENDLCDYEEDLQWLEAIVVELRGKRDELRKYIDSCKACLSPIRLLPVEIIAKISMWYQNAHMHGSGRRDFREPLSKSRDESTEVMTALVLGSVCRLWREIAFSTPSLWAQFSLVLTENCEAQQRLLDIYLSRSKEYPLSFHLNVNHQRGNSIIIALLVNQSHRWFSTSWLFLHDEYMSSLGLGARMDLPHLRYIERSFGRVSEEHASCVFAGTKALQTVSFRGMSRFLHSKLCWDQIHCLSIQDFCPGSDFGPSIPVGSLSTLVWHLAQICPILRSLELDIGENYPLVPADGTRGIYLGMLENLCLEEMRWYEVHKLFSVSTFPNLRRVSVLLDTLYAEHEGDPDMNATALSFFISRSGCSITVLRLERLCQNGVDIACNMLRHIPTLNDLIIREDPYRHNPSVMTTVIETLDISGHPVETLSSAGEEQSDLILPILRRLIMEVNADYFEASGFAGMVKSRAVWGSLESARLYLQWSSSTVEGSVTLLQYLKSLQGSGMEIISSTSTIRRYLKDDFPCWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMB2</accession>
    <name>A0A8H5CMB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMB2"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="64"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="479" mass="51211" checksum="7B6B7BB7ECA3A575" modified="2022-01-19" version="1">MSTVERPLAMAEESVQEVSPSLDQEGTRQTAIMGATEKQARETVRNAQASAEGPPNGGYGWICVLCSFVIHFFALGIESSWGVYQNFYFTSPNEGVGNASNADLAWIGSIQATGQPLVAYLAAIMARKVGFRWTGFFGAIVMAASLIAASFSTKVWHLYLTQGVLYGAGCGFAYIPAIAVPPQWFTARRGLAMGIGSSGYGVGGLVLSPVTEKLIATVGFRWALRITGFLVLGVLAVADYFMKPRVQSEATRFNPKLMKSWLFVSLCVIGFVSAFGFYIPIFYIPTYIQNALGRTAQDGATAAALIAGFSALGRIVMGHVGDRIGPAYTLIICQTISAIFQMLFWPFVRNYSGGLAFSSLFGFTSGGFVTLYPTLAAYIYGSERLATVAGAMFSSFIPGTLVGPPIAGAILDKHTAADGKIDFLAVQIYGGSWMLASAAVAVVCRILHVRWLKEEEGSLSSQDEEKDDAGTVAVQTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN86</accession>
    <name>A0A8H5CN86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN86"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="13004" checksum="CD8B240581A5B5C4" modified="2022-01-19" version="1">MDSFISTLLSQTCNFIYRDLDMPRKCSKSVIAKANRSPEEEASCQRAKSIRREVPEKARERMAKHRANMSEDKAAAKEKRKEYDSKYYLRAFIDKHGEYAFMTIILTEMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNC8</accession>
    <name>A0A8H5CNC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNC8"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="373" mass="41968" checksum="FCA93AF6B3391FDC" modified="2022-01-19" version="1">MADKSSPSPEPMRKRVETYIRKLQHEIVTSLEKLDPNAPPFKRDAWIRPQGGSGQSCVFAMPAQEDGTVAHESVLEKAGVNISIVHGTLPPPALKQMRADHKTLPLPEDVSDGLPFFAAGISLVIHPRNPHAPTSHANYRYFEITEAFSNTQAAEKDTQKEPKVIAWWFGGGADLTPSYLYEEDAVHFHKTLKDASDPFGSLLYPTFKKWCDEYFYIPHRGETRGVGGIFFDDLNELEHAKLKGSAEAGESAGAGSKEKLRPQTQEEIFEFIQSAGNAFVPSYVPIVAKRCSTPYTPQQRRWQLVRRGRYVEFNLVYDRGTKFGLMTPGARIESILMSLPEVARWEYMSDLGEDKESEEGKLLEVVKNPRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNK5</accession>
    <name>A0A8H5CNK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNK5"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="833" mass="94319" checksum="650DB02A1B4B44AD" modified="2022-01-19" version="1">MSNLKDPRGRRLQACDECRRRKVRCDASNMPDNICTQCRNASVSCTHTNSGLKRGPKLGSSRPFASQPIRILIDDILKGSASESFYLLDDKDTVWKLLTKIANHVVSLEQKLERCQREHHVLSEVVEPAAPTSDIQTTYPIEDGDGIDSMDSLSNEFSRFRLGVPKKIHFGDSSHMMLVMTALEHRRELDSGLEEWQSLLLQTKRPEFWNVPTWLTLPEPDVPVFAFPEGKELQTLVNAYFTQNNVFCPLLHRPSFERSVSEGLHLQDSAFGALLLSVCAVGSRYTYLPSDSDGSDPIKSGIKWFNQLPIKQSAFGQSVSLYHLQMYCLASVYLNMVTGPDVGWMLSGIAMRLAQERGTHRRTSGNQKPTLEGELWKRVFWTLVITDTETSMLFGRPSATSTQDFDVGLPVDCDDEYWEHETPDLAFKQPPGQPSLVAFWNCYLTLVEIIGFARQSLYAVRKSEFSVRMGFSGQEWHQKAVMELDSALNKWIDSVPSHLRWDAQAQNNTFFSQSAILHSMYYWVQIQIHRKFIPRPGQKSTLSFPSLAICANAARSCIRVVETYFKQRFLSFGHFMHPLFGSAMVLAVNLWRERQSNVEFNARSELVDIYKCIDMIRLYESRYPLAGRLIDIINTVMSVSRYPPLLVSTPKEIGSDQAPWPDIQIPQASSGPEPSLFHQPSYGDADPARNIVIGEHGDMNLPFYSSELGQLPVHAAPNLGYDFSSPTNEELAIFGDGTQRTVPQNTYLYAGPSQGQSQLVNEFMNQPSTAMNPVLTDAYPIQYRFPAVGLNTENQNWSQNELDRQDWDIFIENVQQLLPTVNASENHGPWMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPA2</accession>
    <name>A0A8H5CPA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPA2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="171" mass="19348" checksum="F98B7700CB1C90B5" modified="2022-01-19" version="1">MSPIGRQTSMIPQTLLYPPGSMQGRQFDPIAFNDTSALVLRYNTGILMDDIRKRTPEEVGGLIVGGMEMMTVIPIEGITVKLMWPDSKLVFSSEIKKYPTLGVPGRNLPVQMNRIELAKKIVKFLDTCWVSFHANHFFDLFDYLPIILPSSLFSNNYVLNRYITFKAPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT95</accession>
    <name>A0A8H5CT95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CT95"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="60"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="235"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="82548" checksum="CE3697A68E7DDD0E" modified="2022-01-19" version="1">MPPNNLSLKQRLALSLAPSSSNGQNLDRNLLSPRRAKAFFTPPWMKKNESGLVAREEYNELEVVQDVMARMIFQAGVDFETRPMVVMNASAMPDPDEVNYDLLLSRILSYLNLYVEADYTVVFFAAGGRHTPGWNWVWKAYRSLNRKYRKNLKKLYIVHSSFFSKMLFSLAGAIISPKFFRKISYLDTLSELAIHIPLTQIDIPPAVYQENLKNESKIIIPNIHSSASSSAAFGVPLEDIMGFEGEKGPVPRVVRDCIQYLRESGLNNEGLFRRSPSSQLLRAAQEAYDRGQVVSLEIWEGAGGGPHLAAVLLKKYLRDLPEPVFGEDMYATIRKCPMPTSDPGDVEAVRYMREVVLPELKPCVYILLSHYLHLMHEVHLRSASNRMDAHNLAVVLSPNLVKGTNPIRDVQMCLIPSVGGTGPTPGVPRSPLGSSSPLPSPGPNSPGFNYPGAGYGPGLSSPILPGPGAGEFAQKYRNPFSPAPPTPIRATSSSSGLLSPAVPTFPNSPRSPNSNASNFPPNPPSPTFVPSLSATTTINTNTTNAANAAAITENKTTLGMVIKLCIQRYYEVFDEVLDRTEVGGFGVDGMGVGVYPGDNLGMGMGTYLLPSQIQSQNMNPDRSRDTSVSASVEGSREGSVVVVGDANGGGGGEGQGPVSLSFGAGAALRSDADARPESESKQKLKPVPINGFASASGALGNGLGRMGMGNGSRSGAAVVGSSTKPKPLQNGAGANNATGTRSTTGGPIIGGPPVKTPLVSLPTQSTTDEKVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU92</accession>
    <name>A0A8H5CU92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU92"/>
    <dbReference type="OrthoDB" id="2654851at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="226"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="473" mass="53336" checksum="DB993E9656A7B8B7" modified="2022-01-19" version="1">MCSIGRFKASLCRSLVASSINIVPVLPQTARVASPRSSRNSSMLSDQFSSQIQSMTPSSKSSLALPNGSGTGSPLVPKNTGNVTMERRTKRRKFVSDLKGLALKPSHDQLYSGNSYHIHEDLTKSSTKASEDWTEHFSEVWATPRTYAEDGKDHSLTTLGTALRRSRSWTSSPRTGLGTRDYSAKMKHFWSTSILSAGQGGDVSFIKAAVATTLHRIEEGDAIPPYAILSHRWGKQADEVGYQELFNKRPTTETLQKTGYQKIIAACKQALVHGLQYLWVDTCCINQHDKDDVHRNIKSMFAYYQHSRICFAYLVDVDGEDFRDSVWFTRGWTLQELLAPLDVIFFNCNWESIGRRNDRSQEISFITGIPEDVIKGETHIHEVDVEEKMFWSAHRETSRPPDQAYCLFGILEVSVEPNYDEDAETAFSRLCEAWFRKFSEESGGRRIMVPTLWVFEIEISGAQGQRGLDLSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZD3</accession>
    <name>A0A8H5CZD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZD3"/>
    <dbReference type="OrthoDB" id="3046318at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="288" mass="31247" checksum="D585C2D98CAFA637" modified="2022-01-19" version="1">MKTASIFDATTVFSAASALLTRRSSEDDYPPTPVPHTNVILHIFFAFQLFSLAGLSVILFTTAITRTWKHPTWINFCVTWIISCISYSLLVGRPLSYVPPHQLCLAQAALIYTVPTLTAFGTFSLVLHVFRMVRHCGDGGKALTIALVVSPYLAASGMMVMALIIGLRDPSTVRRTSSGLYCDMGNEIPGRISAGVVTIVMIVCIILEALISRDVKRQWSFLRASASSRNTMAHSRSTISRNGSRVHRNSEGSNDAQLSDDGEADTTGLIGLAIKVLVFSVFSIFAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D139</accession>
    <name>A0A8H5D139_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D139"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="37972" checksum="231BF540C004376A" modified="2022-01-19" version="1">MTEKTKILMTGITGYIGGSVFCRLMKRPDFSSFDIRAIVRSPEKAEKLKAFGVTPIVGSHSDIALMTKACSEVDVVIATADSDDVRAAEGALAGLKKRFEVTGEKPILINTSGTGLLTDGAKGMYTGKVIYDDADPDQMETLPESQPHRNVDLKIISGDKAGYVQTYIILPSTIWNVATGPLFEAGLSNRRSIQIPAVIRASLALGNGGMVGEGKNMWPNVEVHELAELYNILLDAALSPSSASSLGHGRTGYYFGATDEHTLYDVGKAIAEAMVSMGKGKTAEPMMFPEDEMNRYFPGFWSLMIAQFSGNSRCRATQSRSLGWNPKKGTKELLESIKREVEEEVKAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D299</accession>
    <name>A0A8H5D299_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D299"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="11505" checksum="7F5EB39F58C3F4FE" modified="2022-01-19" version="1">MDWFTRREKHVCIFYTFIYDLLIRNQSDVHPSPLQDFGTPARRKSVLIVDRALAATSGFSETPMAKDKFGSTSDYKDGNWNAPVGDISTLDHEFRSYLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3I2</accession>
    <name>A0A8H5D3I2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3I2"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5352967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="185" mass="20041" checksum="968A0C5D68505FEC" modified="2022-01-19" version="1">MLRRPRSSRTRPLWSFFSSSAYHNEKFLNRYSRNITQPKDQGASQAMLYATDGIKSDEDLSRPMVGIASVWYEGNPCNKHLLGLGRDIKKSVEEAGIIGYQFGTVGVSDGISMGTSGMTYSLQSRDLMADSVETAAGGHWLDGMVVVPGCDKNMPGVLMALGRLNRPGIMVYGGTIRPGSCEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4R5</accession>
    <name>A0A8H5D4R5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4R5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="328" mass="36624" checksum="11E70CEE8F9ECBCF" modified="2022-01-19" version="1">MSKFENTSDQQPQNTNVQQEPFKNLDDLIRNHWPSGTHEGGGALNEELRQTIKTSLEDAKAIAKARIIPLELPHHRCLCFHLYNMVTDMERRANGRFTDFVNLERKAEREGNNAMKNHGEEWGRWWNEHRSKLNQVLKDIETHKLRTLRTPVSDALASDGALLDIPASSGPAGNSADAGPLSAAEKFVKIERGKIAEPGRCLRDMGLVHNLLGVLCCIIERSSKQYKQFPMHPPDILFSSLALVPLGEDTSLILTVLIDVIQITEIAQRVVCRLTSSFSSRRWGYRDLNGAVAPTSTQIYGSLENGDKIKTSSEKEKEKNSNATDEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D812</accession>
    <name>A0A8H5D812_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D812"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5354421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="598" mass="66816" checksum="A5807ECA5B9B9C29" modified="2022-01-19" version="1">MTMSTANSRKPYHGLCRKLVIAFDVGTTFSGASFAILDPGQVPKIQGVTRFPAQVKVGGNCKIPSIIYYDQEGNVRAAGAEARDEAFLEQAEDEGFTKVEWFKLHLRPKGLETSRVRDSDLPSLPPNKSALRVFADFLQYLHKCTIKFIQELGALYAPGTEFWNSLQDNIEFILSHPNGWEGPQQKLMRRAAVLAGLVAEDASQTRIHFVTEGEASLHFCIMNDKVNTGTSSGLIIVDMGGGTIDLSAYYPSGQNSFEEIARTRCLLQGSVYVSHRARAYLKEKLSGSKYGTDEDINQIVQVFDKTTKVVFRDSSSPAFIRFGTTRDRDPNVDIRNGQLKLAGDVVDKFFEPSLRETIQAIKEMREESTKNLTSVLLVGGFSPNEWLFTSLQQALVPLGMSLSRPDGHLNKAVPDGALSFHLDHFVSVRVSKYTYGTKISVKYDSTDPEHRRRSHFITTKPSGTKVLPSAFDEILAKDTRVHEVKEFSRNYRMEAASLELLKTVNADIISYRGKYGTPEWIDVEPHTFSTLCSVVVDARKAAKNQRTALSRSYYTVDFKVILLLGLTEMKAQISWIEDGMERRSPATVVYDVGMSVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8H1</accession>
    <name>A0A8H5D8H1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8H1"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5355455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="445" mass="51623" checksum="411C9EA6CD44D6AA" modified="2022-01-19" version="1">MTHDVETYYNKEDIKVIERFFDLPLDHANPSGEKIRVFARNLIPRKKAKSQREEEELPYLIYLPGGPGFEVGLMGSSGFAGEIHEQGYQTLWLDPRGTGLSTPITPDTLPSRLKTDQDIADYFKFFRADSIVKDCEAIRKILLGNKEKEEDRKWTIMGQSFGGFCSITYLSFHSEGLKDVFITGGLAPLGDHPDPNYEWTVRKVIRRNESYYQKYPRDKKRIRDICTFLDGNEVILPSGGRLSVRRFQQLGIDFGGIDRVHQMVLRASNDLELFGKISYKVLQTIENSQSFDGRPIYAIIHEPVKSSRWSAHRVVQKYPQYFSWTHIKDLADTDPIYFTGEMIFPEMFDDYKNLRPLKGAAEILARDDSWGPLYDLDQLSRNEVHVTTATYYNDMYVPFELSQETASKIKNTEQYITNQLEHSGIREDPKDLMKRLFRLAKREYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCI8</accession>
    <name>A0A8H5FCI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000318">
        <property type="protein sequence ID" value="KAF5331781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCI8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="164" mass="17539" checksum="A1529820A7924B38" modified="2022-01-19" version="1">MRPFLPVIPTDAPTGQCNGDGDGPASHQEISCDGWAVIHDRYASHPPFLAILAVSRPALCGTKYSIWINAQALHVFRPFFLSATPSPLPSTRLPEISFTSNCTLFWLGVLAIRASSSILKGVEFDYEAPGSSFLTVLALCYDVLAFGLPLSSSTVTISNGPPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCT5</accession>
    <name>A0A8H5FCT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000312">
        <property type="protein sequence ID" value="KAF5332320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCT5"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="234" mass="26144" checksum="2A3CFB61680B4C74" modified="2022-01-19" version="1">MQAYEIPSERVYLPNPSLRSPRLNESFTLLRESSAVVTARSKRIEKEMVDAGLIPPPQPALPTLPPKTENPRDSTVSLNSRSGKNAAVDEEEEAIGLHVGAKFAEKYIATSEAGTRQKSSQLPPYPRMTPKLTATLDVIKFVCKDLWAACWDKQVDNLRTNHRLTKSIQGIYVLQDNAFKTITRLSSWEGRADATRKAKLYVAMPAGLIKGALQWLDCWSHSREPEKYGIHTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEM5</accession>
    <name>A0A8H5FEM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000275">
        <property type="protein sequence ID" value="KAF5333989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEM5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="11757" checksum="0FAC34A7FA2612BC" modified="2022-01-19" version="1">MSRRTSTSTAPFMHLMTHKQGMWFIVMIAERLSGHRDCFARENGKESPEVTVKYRYQSPSRTSSVRQFYYLRLSSTSQTDVFESLRRSLRSNDLKIFNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGQ2</accession>
    <name>A0A8H5FGQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000232">
        <property type="protein sequence ID" value="KAF5335922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGQ2"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF29">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5335922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="558" mass="61586" checksum="39B4563B3C2FCE07" modified="2022-01-19" version="1">MRSGHIQPSAKSATTTSVRSHFIARLGPRSCLMKCVRLSVWNSLLSFPSELETLGAIDNSEVLTLNPLYHLAMSESSNLTYKIEPLKGGDNYRTWKVKMIDILTDLDLLEYVDGSHAEPADQSAKEDWKKKDRKALSTIRLRVDDSCLIYVEDSKTSKEAWDALNDMYEAKGPIAIVLLRRKMFTVRCEEGGDIETHIKLMRSYQSQMNTLGQKIEKADFSMLLLTSLPDSWDSFISTFGSTDLEDSNKVIQRILQEASRRNERSANSDAVLTSSSKPSGKSKFNPRITCYCCGRLGHIAAECRCPKCRNKSGNSQTSNQSRNNRSSHAHVAEAPDSDSDKEGPTYVFAAVDAAIPTVSHTSGLSSDAWLLDTGCTRHVVRNKEYFVDYVETPGHQLIGLGISSGLGTGTVNLTLTEGKETTRIALSNTIHCPTAPYNLISVGKILSAGITPVFQGKNQLNLVNSHGTIIGHAVKTAGLFPIDASVAEPTRAHPAIAEIDAKTWEEWHRFYGHLNIGSLKLLKDKAPQNSNAFHVFNQKATRRRSLKKQSATSLNPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI36</accession>
    <name>A0A8H5FI36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000213">
        <property type="protein sequence ID" value="KAF5337601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI36"/>
    <dbReference type="OrthoDB" id="3265564at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="32649" checksum="B963101AC5EB86CD" modified="2022-01-19" version="1">MEARGDPPRMNPSNRQKDEVGKIRMSMIVIPDWRSGFFSSQIRDLNVQNFLVERQTYKSTPSRSLTCYHSTHILSTYTQTIIKMRAAFSIFATLACAAVSFAAPVNVGAEALNGVVGVGAKVDLPVALPPAGVAVNANPVAAAAVSTRDAATVPDIIQDLTTSLQPLVAQLNSFTTENISLSVVQPILEDVKGVLNTAITDVQALAGQPVNTLLQTVNGVLSLTDVIGLLTTVISLVFGAVHTVLTLVNGLTDANVITSLLGEVVALVGQLLQVLVGVVGGLLGLVVPLLTPVLTIVSQLGVTQAFSGLGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI75</accession>
    <name>A0A8H5FI75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="583"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="950"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1288" mass="139593" checksum="073AA1CD66DD4E24" modified="2022-01-19" version="1">MRSLAAGKNNRLILSGTQELHDRISQLCSRIRELEEALASVQSRVSDEPHPLLKSELLMIKVPLNLTVPHNNANSGVSSSELHPSHVLNGNANSHPNHNRSDGVRVGNGVPEVPGASASLSVPAITPTTTPSSSSSHAVSSGSSVGVNGPANNSSTKDENFIDAFGTLSIGCNGETSFLGKTARSEYLIRVCFVTFGSFEHANAFVHQLLHLVFLPCLVTTSLLQPQLYPHQRQHQALSKPSHASSSSYDCPRLPKKIIDSRCPNEVSSLSSAASSSSNNSTTTNGGGVNGTGYSYSSGVNRHGGGHGGGRGMDMGMGARIGGQEEDPDDPDSLGAEIWGLLPELSEALRLCDVYLEAGRYMYAALPRNELLDDILAPVYRVDSFSSLSNVHTLGLLFIIFALGALFDQDQQPYSLEAKEYFLLARAAKNYATGVEMRGKKSGVGTSGHGVNGVGGGSVYGNGNGDDEDQEWDEAGGEYEDEVDIDVDVDVDESEREGEGGWESDGSSPHSRRAQHRHRSVNGREGALRRGGGGNGGGGVLRTTGEGGGGDSWGMSVIGLWTMIHMSQYLEFSDWEALGSQTAWWWVGFSVRLAVGLGLHLNSARWEICEEMQKKRALVFWQIFTVDTWLSFNYGRPPSLSRTYIDCPLPEDTDEYVGGNGKEIGCEYPLLSSSAFVWFGFSALTHHRFFLFLSPLFFPSTLYLRPTSPHLDLPIHLLHAHHHRKRFWPHISPYSLIIDFDRQVRDFPVPQHLRPRCHLDPTEMLMATGGREHVKNIQGLSMQRWMTMSYKEATLLNLHRAYFAQALQDSPDDLASHKYLPSVMATYRSAWRLIQGLKMMWRHIPRLLERYNLAWSQALSAAIVMCILVTRSPHSKMTKSSLAELDTVVELFEDASSTCRSAANILDTLKNLRHKAHEAVDQKQYLSDLASSKLSVDELDRLGGRTHLIAAMSASHSSTSKSTRRRSKAGSHTSSSNSNSTSPISNHESPTSASSPNAGSQPHQVGSSMPFPPPLLETTNLVPAPSHSQPQSQPQFQPQSQTQTQPQSQCQTFQDLFPTETMHPSIARDMQMMDIINDPSLTLSTGPGPWPPFYDLPTGLPGLASMAPPSLPQYASSSVPLLSRNGGNGGRSAGGIHTMSTSPIYSEPSGGRGLFHSEESSPDEPMSDIQFPDPQSQSHSAGRRYSIATTATAVTDISSSNGGGGSGSGMDWSSMNMGMGGMGMMGMNVNVPPEGWPSSVPFVDVPFYDHPSRSPMGFPTGSYSGINPISGAPILDATWQSFVEQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIP8</accession>
    <name>A0A8H5FIP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIP8"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58693" checksum="EF4A58CAEAF7E8C0" modified="2022-01-19" version="1">MHLSYPNHPQQQHKKLELKLRHLHPSRLFRWRCQCIRPLIVMGLFAALSFFYILHGHYRPPEVTRSLEVKLLGMRMIPLHVKEWIAVAEGRTPGPMIPLSSKSSFADDHYNTHLHSDQSLNPSSESIYVINLPDRSDRRAEIELLRIYMGMKWTYVDATSKNDIIVSQVIQNVKDTRRKAVQASLQKVMHKQAVDGPWSPVRLPFRWPAYFDNDYALRDLDPSFLYDDFDALHTPSSSLSSPSADSVDFDSVTALYLKEPLAVARKDFTLWPYNPSLPRWKIMTRSRFACWHSHLQTLRRIVAAQDITQAGTAHEDRVVGDHVSIILEDDIDMEVDIRSRLGAIWASLPLDWDIVFLGYCWSNESYYPAISQSQHVNFHPDPPPSSSSSQAFATSRYCANRVCTTLHPSYAPKCTHAYALSPQGARRLLAHLTYPPFAYSRAIDQAFAWLVKSKRIKAYSVVPPVVVQRKDTKSDLWSYRAEDSESGERKSKGSEWRDELASGVFGTRLGNGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKE5</accession>
    <name>A0A8H5FKE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isomerase YbhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKE5"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="42284" checksum="DC2D390F3109C74C" modified="2022-01-19" version="1">MVNFTILAGGFDIAGTLPFIATYLFNSEAGSLDVVGQFPTGGNCSWISSGLTNRSVLYAVNEVSPTGALQSFTVTSEGFLSPAVDTISSEGDRPAYTTALSNFGRPQIAVMDYNSGNGRIVPLSKDGLHFDDSAASAGVITFPVPAAPTSEGVSHPHMVLELDEEILVPDLGGDTIWRLTQEATGNWTIVGSIPQPPSSGPRHLAVHNGFLYTLHETASTLTLQRLPAFPNGTSEIIANVSTIPSNPLPGAIWAAAEILIPKSTSQFPIPYIYVSNRNTGVPDATGKGDSIAIFEHVHAGTSMAAEGSLKLVTQVFTGLQQIRGMEIGLEGNRGNEFLIAAGVAGEGGTVVYKRVDGGRRLEEVARNLDIPTRSTFAKFSDDAGARFYDELLRLNLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLN5</accession>
    <name>A0A8H5FLN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HCR1</name>
        <name evidence="6" type="ORF">D9758_012189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLN5"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5340918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="233" mass="25636" checksum="B6E80745F68E71CC" modified="2022-01-19" version="1">MSDWEASDEDQVANPPAKVTAKAKGKWEGEDEEDGAPASDWEDSSEEEDKSASAPKEAAKAAQKDEDDPYDSDAVLDPREKARRDREKELAADLNNAADLFGAAAHGGTSSKELDSLLSFQPRTKEDFVKLSSMIIEFVVKRHQNKPLYPTFVEHHVRELAQPLKDVEVRKAASGLTTLANEKQKDQRDKASGKKKKNAAKPALGGAKSMNKLDTSVYDEALDDFGNQPDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNR3</accession>
    <name>A0A8H5FNR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNR3"/>
    <dbReference type="OrthoDB" id="3237371at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="713" mass="78261" checksum="952D9982D61DA088" modified="2022-01-19" version="1">MARRTQMTASPAATPPPKAPNHSPTLPVEKTGIVQGPVHNGMTLRGQRDAHPAKPDMPAPRRPHEVVQAEKKAKQKKKDERTTKQQNAIEKTALLEDTMQLQEEEAARTANHPITSKAVKKPRVNLKKVPAESQTPSEARDAEGPVVEESSELDDSGNEKFELDGSDNESDDSDEGQPRKKKLAVKSKTALRETINEKRQNPEPALIPTPTPEPAKKKPKANVGGLRADWLQANASKINTPKRITSEPSSQVGASIAPIATVAHAVQEDDEYKFGGLVGEENDMEERKELGTAGSKDTEAEAVAAVVKAHVLVKIEETTSVSGFVSPDKTKKTITLNAFPDKVQKAFTDHFIPSVLDFVGCLKAWTGLEAQEYSDLWETTTSDEVKNAWDQLNGPKRLLEVLTNDRINSWRSKFGTTAINVLDDIFTREQLETAEDKKAYVETQLQGNPKSRAFYFLHSGEVNGAMQYAGTFQSELIARTFAEHLKAIRQVPKDLRQEMKPTGALVLSILAVLRALEFYKTGVFIKPMGNNGHFSERAWGDRIIQTQGRTINIKTTTELHELFEFNQVKNTPRVSDTQWKRILATAQSYIAARRGGSEGYAPVQQKRVDPEDWMMPELAQSKASGKTEIDAADIAGTGATVEGSIDGTSQGEVTTSTGTSARNDIIDDVVMNSADGEGLGNISGEDEEEGDEEEDEEEQDEGSMQLKAVTSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRC3</accession>
    <name>A0A8H5FRC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRC3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="44579" checksum="A575D201F02A2F6A" modified="2022-01-19" version="1">MCLNPVSVVPAKRKVEVDEKEREKVEGKKVKLDDGKEGQRTRLDSVDVDVKVGERQRQTSTPTIIITKVPDKHQTEAQPRSPYRNAGRVILSDSESDEDAGRGRRGSQGQGQFTLQVVCIKQIPAQVSVSAAPVQIHSKSKPSPKPSSSSTSIPAAADISVKKPKAELKADNAKVKAIPSYSYSVSSSSSSESPAIGVAAAFNSASDTNYSEMTISQSKAKEKAKTKTSSRLVRRNLDLGCWYRNPPRRLPLPHRLPALFTSRVQDASKSKTMEKEKGIPRGQTKPKTQNAAQPQLHRLKTTTLQAKPTKTKGIGKGTGSGAFEDKAKASKLKTVVKPSLPSRGLGWSSSLSSESESEDEDEDESRSGSDDGSGSGSGSGESESESDLSDSDSGSDSGAPVPSKKTDEGKVFYRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT42</accession>
    <name>A0A8H5FT42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT42"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32974" checksum="1FE88F4698ACD67D" modified="2022-01-19" version="1">MLGSHTRPYLDIPGLTQTFGDGYRPEAPAKKPTQHEQDEADDKARRRAMNDLVQSWMDRLQLISLITTFLASVEAGMLQVTKSDDENVSGLEQATNASLLSALVLHLYASFISFFAAFFLIRYKVKEAKREEAKVESSTNGNSSTSGSGPPPQSKGSILIDMAAKHVTGSPETLSPKSTVTSTETSKEGKVEVGANSEAQQNAQVHPPQLPPPAIWSADPHLQLVRAGPFQRQPPIALLSRCHSLCLLFATLGFLLALAGIMLYSWTQQTAVKAVTTGVLGLGILSGAAISTARIKDHTELTTIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUN2</accession>
    <name>A0A8H5FUN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000081">
        <property type="protein sequence ID" value="KAF5349393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUN2"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034550615" description="FAD-binding domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5349393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="418" mass="46908" checksum="752B66C277DAB7CC" modified="2022-01-19" version="1">MSSGSRLRVAICGAGIAGLTCALALSEYPDIEIDVFESAGKLAEVGAGIGLFPRPWQIIRKLGLEQDLLKTTESKLIEGRAPSFRYRKSDQREGVEFFRLYTQGSLILLHRADYQQTLLHHLPKSCRTHCSKRLLSYRQSHNRHGVDLFFEDGTSYSCDVLIGADGLKSAVRRCMLHEKSGIAQAEGRWKESMELLRSVDPIWSGQNAYRALIPAEKLRARAPSHSVFTAPMQYLGKNGYVLTYPISGGKMINFVAFDIRHELENTKFNGPWVSTSNKSRFASRFADWEPEVQTLLECVEEPLQWAIHTIPPMKSFISGRVTVMGDAAHAMTPHEGSGAGQAIEDAYLLATVLGHPRTNSTNVHHTLSVYDSIRRPLAYDVMEHSRMNGHYFSLNVDGVDFDSNSVSVRENNWRIYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW44</accession>
    <name>A0A8H5FW44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW44"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="82"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="473"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5351311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="87101" checksum="A5BD3E1C844FFE63" modified="2022-01-19" version="1">MQSPPSDEPPFDFPHFLDQIKHRSAESVTKYLKSFLSNFSKRTFTLNDQIKIINDFLAFIAKQMRESISAVLPRRPLTTDDLERDRVLAQRISLFSSWIEEKHLDIPVAEGSKGFLMFAQQELLKINHYKAPQDKFICVLNCCKVIYGLIRHLSTLKEKEKEAKTAEAETEKDEKDEKDEEDKPSLSLADSANDFFPILIFIVIKSNPPHLISNVEFIQRFRNPSKLQSEAGYYLSSLMGAVTFIETMDYADLSGISKEDFEAELEKPIQTQEHQERLQPSSTARTDSSSSSDFTETPTQPDHQPPATSSGSATPLNLPNLPNITNISSSLTRELRGLDLSVGEDARRFIQRTGDAIKTPLNKIGRTMSDEVATFDHSFSSDIAHGPSRHRQVLKETLAILHSISPQDEEKVALLPLLELRGEEAQYRLDILQTIADSPQQLDQRVRFLTLKTIFHLSQESQQYPQCYVIKNLVLGKRIARGAYGVLREGKIAIGSESEPGIEGPHRTDYAVKIVELFPGSIEIVVRLYTGSRTLEAVQTSKRATLPGMYYQNDKREDLCFVSPYMNNRSLSIMLKDRTPSQEDMYTLVHDIASGLKYLHDENVIHGDLKPDNVLITNHSRACLCDFGQSRLASTRGFQPTRHQGGGTHGYMAPEVTRDGRSSKEGDIYSFGPLCYEILKKTYNLSGLKWLSTNKVDTTRPERLPSARDLDSMWNMITQCLSKQPSVRPDVKNLISLLNGMSSKPRPAPDWDDTDPLFTQVQSNVDHGGVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWB7</accession>
    <name>A0A8H5FWB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWB7"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="695"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5351536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116966" checksum="9B0854740DB077BF" modified="2022-01-19" version="1">MKNYNAFKGRSTFTRPPLDQSLPLALLFDYHGTNSPNHPLFRYDEDGELKTILWKDATAAIRRAAGLVSEYVSQNGDDIPVVAVLANVDSMTYFATIAGIMRAGYQPFPLSTRNSPAAISHLVQKKNVHHIFVNTEGPIRDQINAAIQDSDLAVNVHDMPTFDALYKSNKTVDLPSLEGVTQNSVAIILHSSGSTAFPKPIALSMRLFMESAMSAYYGEIDIGSQVLSAHAVPMFHFMGVIQIAWTAFLGLTVSVFPPTTPPVIPTPDSVFNAAVKTNSSLLYCVPSFVEALARDPEKVKVLSNFSSVLYAGGPLETTTGDTLFEAGVKIVPLYGQTESGTINHLFPSGPDPLGWQWMRISEHVDPVFVPSDVDHLFKLVLKKCPGHTPAILNTFIDGVPALDTFDLVTRHPQDPRLFQIYGRADDQIMHSTGEKTNPGPIEGILVTDPNIDGAIMFGRSKFYAGVIITPSPDKVFDPQDTEKLAEYRSLIWPTVEKANDFAPAHSRIFKEMILVTHPDKPFQRTPKGSPKRNAVLKDYAEEIEAAYTAFDESSQTQFDPPKSWNAEDCISFVRAAFQSIMKGDLELGDEDDIFQRGCDSLQVTWIRNTVLHALKFNDQVNIREIPQNFVYTYPTARQLGEYMANLAQGKALETTDTSSRAQQMKSLVNKYTKDFPKRDQIASGAKCDTPGAVLITGTTGYLGSHLLARLLESKEFAKVYALNRPSSTTLVSRQEKSFNGRGLDIALLGSPKLVLLEGDSSKPLLGLQNEVYDTLRNELTLIIHNAWRVDFNVSLASLEPHLQGTRNLLDLALTSRREIVPRIVFVSSIAVFNNWHSDKPGPEDYLADPAISVSSGYGESKWCGENILCEASLQTPLKPVIVRVGQICGGPNGEWNTTEWFPALVRSSQTLKKLPILGGHLSWVPIDVAAQVITELSNSRYQFANLVHPHPTTASDILDLVAPMIGAEIVPYAQWIEELNKSQSSAADPARNPALKLLEFFQSQVATADNVNGEVLGLPSLSTAQTVECSHTLKTLTQHQLGSEDVEKWIGYWRRIGFLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZT6</accession>
    <name>A0A8H5FZT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZT6"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="204" mass="21991" checksum="3A5EFF6DD09BC98A" modified="2022-01-19" version="1">MLPSLDAVINSAPSDPNSPLSLTLSTLFESSSILQNKLVPQLHDVLQSSNPPISTYAQLIDLAIDQLSTWDHESQSKFISGHPRIGETKNLSKLSAKEQNATPSAAGTTPPEVLARLAHLNGCYEKRYPGLVYIIFVNGRSRAAVAEIMEAQLGLEHSLSPDTPAVDSIEPVQVGGEDWTSELNRAVRDVSLIAKSRLKALGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G077</accession>
    <name>A0A8H5G077_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G077"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="86693" checksum="8163CD0C925A82DB" modified="2022-01-19" version="1">MAESAKSPICWLPIEILTEIFQWHCEECSLFIEAFLWNEKTEQYDRCKASTPTLDVAQTCSLWQNIAISRPTLWSRVDVDLNCGSQSFVDLVTLYLSRSKTASLSLILRAEGEGTRYSVDLKESGQSMLKALVMENYRWEWVEFDMTMAALGQYSTPVTSGDCENLEVLLIPCESDLAYSHEVQVFSRVVGYTPMLHTLMFNGVWETGLITRNSLPFAQLLDIDIEGKEVNLTQLQDLLDRCVALKHLYVIPEFDHHPILPIPPSRVGLSHCQNLEELFVDVSDRNESPCNGIIASAYFFQILRAPALRYLWLEGQNDDAEERSACFDSVKKFLHVSECQLDRLQLTGDLLDTDMVLQLFELLPTLTELEISKGRDRLRLFDALTIPHQPLGSDSQPVNQTQSRKVLLPKLTSLAFEITLEDEELVSEKPVSLSQAQVDSEDEDEWMELQTTDSQDTLQDLEEGSKDNENENEGEGIIAVHNIQNIQEMTVKSLTVDFQQVDRSNDLEMQEQETAPKTCQLAMEDVEVEEQEQDHGTDNQDTVANHGAGEPQSTGNGPRLDDKIEEFGTQTGGVDPHEDSAVVKSSDFEMQGEEMSTKTYQVITEGKEVDREPEPDAETNDLGAIKPGTGESPRQSTDNGPRPDDVEMRTQMDNVDAHQDSLEEDKKSLTSEFQVDQSNSAERCSPLSEAGVDGVQLSGYPSDTIRTMLCSRRNSSDSNVRILERFTFSVHRGTAPSTEPVVKWFDKFCTTTAPQLRTLAGKGLKLELDVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G159</accession>
    <name>A0A8H5G159_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G159"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="66137" checksum="F957BB8EEFD53E20" modified="2022-01-19" version="1">MSSPLKRRAATKVISYQEEDDLFNEELAVDTSTSRNSRKRSQNASDHYEDEAMPVDNSSSEEYEEKEVPSLSSKSKGRKRAPRKDLNSSPKKTPRKSTGKTKKKSKLDMSQFFWPAYRAQMEGGCCIFEFCDPTKLLLLFHTPDLRDILLKAPDAVWRAARENVGMPELEAKDISERQYITLVFNKDCHNNCGMRNVQRVNFVNCARLCGDCLFATKFERKSQYEKYLRSLHPKAFECAKDSAFSDTGYRKPRGIEKLLAKLRDMRGKELDDFVEHRRILKEQIARDARRIREWVDQQDTKRYQSAEDKKQSRKVAIRAKLLSPEMGWNEDDLDDVFWAGWKEIDQPAELTPAIWKRIKDPLLNTLRLRLIETRNRERRDVLRARYRVLLQDDPKPDIFPSFETFSHFPDVEPLWNKNKCSGDDTPEPVERETFVVLDETEWNAALVPIKASVATYQVEMETLAKERLVKAYTDKGLVVPSDPIQDPRSMFRYKAPLVLNLDYPDERDAVLPFPAIHRVMRDRQDGSRFNVVAAVAAEFRTVPEVRGWFDGRNDTLKVDLGATACEGGMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G382</accession>
    <name>A0A8H5G382_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G382"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034457760" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="227"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5357494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="368" mass="40750" checksum="03CFC402E29DD6A2" modified="2022-01-19" version="1">MLSSTKLHSFASALIIYALSASATQELTLKLTGTEIADGVDNLKVVASLSNTGDETLQVLNDPRSILSSHPTNSFSISDADGAAPSFNGMKVKYSPSFAARKNYTNAFTTLTPGQSVEVEHDLSNAYNFTQSGASRYNIIPASTFYIYDLQTQEVSKLKAKIQGEHSSKLHGRLAVSRRSFAKRCDDDHDDDEEPTGPAFQKCNHKQRRQIRRAVQVATKYAHNAHDYLTDHTNATDRYETWFGEYNKTRHRTVTKHYANLVEQGYKNYTYDCGTCDDNGTFAYVYTEPDAFGTIYLCGAFWRANATGTDSRGGTLVHESTHFTKLAGTADHVYGQSGAKDLAKEDPDEAITNADTHEYFAENHPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3J2</accession>
    <name>A0A8H5G3J2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3J2"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034585986" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="18"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="429"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5357648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="551" mass="61776" checksum="CC3E6FB050817A6C" modified="2022-01-19" version="1">MLPPWLVLSLFPLSALGAIDRTFGVAPDLLPKYAPRKDGTWNCLDGSKEIPWNFVNDDSCDCPDGSDEPGTGACPDTYFYCKNEGHTGSLIPSSRVKDGLCEPQCCDGSDERQGVCPNVCQEVGEAHRKKLAEELKLRKTGSKIRSSYITYAQKEKKRLEGVIENNAKEILLREKEYERLKDIADRTESLSAAALEHKQQSPLYLSLIDHSNALKSLQREHNKLLEREKELSNILDTLRTGYNPNYQDMAVLEAVRGWEYIAGLPHINDVGKNGGDSDVSDEEAGISDSSENVEEEEELEEGMWTKEELDKELDDLLKSDYVSLLMEHEEHVRSPVEGSLIFDIASYLPDSVVPQYEDFKDILLGWMAMFGIIREQEGADTSRARQALQDAENALNKVKREKENAEQDIQKIFDPTMFGAEGEWKKLDGTCLEYPSGDYVYELCFFGEAKQKPTKGGSTFTLGRFSSWNKSPEVQVGSPEYYSKQVYDRGTKCWNGPERSVVLVMTCGTENAIHSVQELEKCEYQFTGTTPALCLPVDSNGNGKAGSREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5A1</accession>
    <name>A0A8H5G5A1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5A1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034199428" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="391" mass="42154" checksum="0CA900D77F9DCAFD" modified="2022-01-19" version="1">MTMSFRQIVLYFLVWLPCAFGTYVPLREYSGQSFFDGWDYYGNVDNTTWGNVSYVDQTTAMTQQLTFVDGNGHAVIRVDNTTFIPDAPLVNRNTIKITSKDAYPVGSLFLIDAYHIPYGCSVWPSLWTLGANIEWPNGGEIDVIEAINMLPQNQMALHTLPGCWQAGDNGQTGLTDTNDCSTPQGCLVQETKPNSYNSGFAAAGGGMFALQLDVSGIYMWFWSRPDVPHSITSATSSSTFDDLTDWGAPSAAYPAAGCNIAQYFQPQQLIIDITLCGVWAGVPDIYSSTCPNTCLSNVIGSGNPVYNTAYWELGYIRTYAAAAVPGAGQVNAGSTDGQSPSTTSASTNPSVTVTPAPDQNDAIAVGITKLTNIMTTAKLCILFSFMTFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G9W8</accession>
    <name>A0A8H5G9W8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G9W8"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="379" mass="43464" checksum="92C64704782C01A3" modified="2022-01-19" version="1">MASTGLRATLTPQLIHIPRSPTATITSSTDVDSPVVVNFEDAEDSGNDNHLPAFSEIDEPPPNFAPYRAEWERVDYEENIVSHDSHLNTDPEALYRFLLQQSATPPKVYINCKGTHFEYGSEHGHGTVTDFDFLVSLNDYLECKVTHWTVADDEPAYRGRDVLEVEEKGWSGSGSWWRRREASRSEKRLWRSMWSRRIRQGLPPWVVKGSGVEDVSGIPQQFHSAEALRSSKSIRQWAEDYCAYEDALKEFCYRKVVYGWDLDFISQSIHRAICIKGSKKVDVQVNVVYRDNRVSVKPDNRYSRALSNPSMRDLLTVTLVYPVILACKRFGAKLGARWEVCGGGYRLARDHLNEQGWVEEWVPKILQEVQRGNRSRRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA60</accession>
    <name>A0A8H5GA60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA60"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="149"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="332"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5361262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="62732" checksum="7BE3AAB468447CB8" modified="2022-01-19" version="1">MLVFRLGPRPSFLNPSLCFLRITMSGKPSNATVVMTLKRNISAVVEEEETQPRASSLRRSTRAKKAKLAVGTSQETEMEMEMDPETSASSSKPKEKPPKAKRKAMSPEDVDEDTDSNYEPLCKLRVWTSLPWKVGAHVSAAGGVENSVTNAARIGANAFALFVKSQRKWESPPLKPESVASFKDNMKVLGYEAKYVLPHGSYLINLGNPDEEKREKSYQCFLDDLKRCEELGLELYNFHPGSTLGQVEPSVSIKHIADCINRAHKETPGSRVCVVLENMVVPIPVLSATSLTFPYSSPFPFPLSCPLSLSVFRPTHQPSFLFAHFASQRQAGAGNVIGSSFSELGQIISQVEDKTRVGACLDTCHMFAAGYDIRTKEGWENTMQTFDRDVGLKYLCGMHLNDSQTPCGSRRDRHENVGIGHLSLHTFSHILTDARTQDIPLILETPCYEDAEKKGGIEKHEIWRKEVGVLNRLSLSNRQSLSTGTFGVSGISSSGTKGEVGGKEEGGEEEERIETLVEEIREVVGRAKAGAGSAKQKGKKSTEKAKGMGTGKMKGKGKASKTRDEDEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAS3</accession>
    <name>A0A8H5GAS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAS3"/>
    <dbReference type="OrthoDB" id="3210574at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="14219" checksum="CB610C91261FB03D" modified="2022-01-19" version="1">MSSINPTTRPEHQVHGSSDPLPGARGAQSGAVDYSPETIERLPASHLNDQGAPAVHGEGQNAFNSDRPMNVQPTPAGGVAVDGRADLPEGKASMMDKVVGKTEKVLGKATKNAELHEKGELREAGGKAAAAGGAKAPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB53</accession>
    <name>A0A8H5GB53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB53"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="35897" checksum="29EBBD5F610FB52B" modified="2022-01-19" version="1">MAPSQRIAIAGGTGKIGLHIVESLLSLKASLPFLHVLVLSRSVKPEQSNITFAGFSAPVVAVDYNNVSSIESVLREHNIDTVISTLFGGVDVFDVAQQNLLTASLNISTIHRFAPSELSWDSETADSVAIYVKKRPILQRLREIKASRTREGIPFEYTKFVTGMVMNIFAVGNPKPNGLDAMGHFPPMYFMFDLKKGTAEILGDGEGMLWTSRIQDIGEFVAHATQLDEWPEQLDLVGDVRSVKDVKRLVEDILGKKLDVTYHSEEELQSKLDPNPSSIVNNMFFEVLLGFGRGEVKRSETYAGLKDVVKPVGLEEYLREWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDQ0</accession>
    <name>A0A8H5GDQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDQ0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="717" mass="76961" checksum="78A7E56D770B69ED" modified="2022-01-19" version="1">MTEAGGGDQSVGRVIIARVNSFLPTPSHLTTPPKLKPSGSKAASGSKANKPAAKKWSHAPFGRSDSKATSNEESLSDRESGGTSVLAKTTETISKPVKKAPAEQPKPKKSSITQRVVRKRLPPSPEVDEGLGDEEDQLDEMDYDIPLEPLGPVPEEPDVDASGEDGLRDGSEIPVPFTGSLRHGSEGQEEEVADSEQQDSPSDPEADVEAEVDAREDEGVRLDRTSFKAKDDIREVSPVVDMADDGPGDKAGKGRSPTPVASAAPTAVPAKSVPSRQPSDSGSSRSKPAPKATTNAVAGPSRVGPASENATESATLKIGPPKKVYSGSNGFPRDKPKRDLPKTITPITPPPRTNTDKSRPRTPKLSPNALKQLAEFDAFMAPLFPEPAPAVTLPAPVNGANVTDNHGHPPSPVSPSSPQNNLNARDNDTPPRPHSPSQARVKDTPTSDHDTNPYPNGVLEPEPLTSEHLQPSNPSPSSPKRRTIKSQMKPRSPGPLKHAPMKPMKPMTPNRMKAMYNSVGKSMFEQPDSTIQQFSDDGTEPSASQISQFESPEKQRQVATPLLQKGGGLLSLGLEMKGTKRSNPFNRLTTVTEVDMDVRQKGEALAEKHRKQILLERNGGEIQKKRVEDIQAERMNAPGKGKTVMFVEPTPTPTPEDVPAEPPEYEDGDQEWPSEVRTGSARGVRAMEWGLKTDWSDPSSSVTVCIAGGRRRGRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGL8</accession>
    <name>A0A8H5GGL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGL8"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="424" mass="47519" checksum="C964362303F4C306" modified="2022-01-19" version="1">MLVAIYDMFSTPPGVPMATPHISANNPDVKPVFMTSQWMLCERESRHLLITGSTNSDLYLWEWGDDHQLFETFNKVPSTIARDGQVSDREIISLDVYEAYVPDGCHGRVAASFASRIVKVWSVSLTSKEVTMVFRVSMEETFIPATVKFRKDLDLFVFKARNGAIRLLDQRTGETIRTDLVKGDFLGDVCVDEDRNAFLVWSGKHFEMFSLTTQRHLQTFDGGISLNHLPRQAKFMGDGKFVLAGSESGAAFLYDTESGSIIQTLAYNKCHVRTVAVSESSKYRLLATAGSAPAEVNKIKVYYKPLPTASTPKAPQSVVGNEDEWVVSVRPYRIWRLAKYFVWLSITLLGVYVAFISVVYIPETVRAWLFPGQPFPFENSLRTRACPTLAQGTNLPAVIVPDHAVQNGLALYQYSCHFPDCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI02</accession>
    <name>A0A8H5GI02_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI02"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034259203" description="Enoyl reductase (ER) domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="32"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="392" mass="42850" checksum="8CDF99D2CC5A23BF" modified="2022-01-19" version="1">MTRPLLRLSLLPLLAIQNPFIMHAILVKDGKGPIENLYLGEAPEPMLRPGQVIVKIKAFGLNGMDILQREGRYPAPPGASEILGVEFSGTITALSEGVPDFKVGDAVFGLAGGGAYAEYIAVESSLLLPKPPHLSWIEAASIPEVFLTAYQAIVMYCETKKDEHVLIHAAASGVGIAAIQLARTRGASVFRRDHHPHGHSISSIFFFAFFRRTVTATASTKEKLDWLLSMPNGATHTVNYKTQDFAEETKKISEGHGVDAVVDFVGQSHWKKNIDALARDGRMTMLAMLSGTIGSTVVIIAAGSVVQEVNLADLLYKRLRVEGSTLRSRTVEYQADLVLRFSKEILPNITGPNGKGPIKTYIHKVYSWTKIQEAHRDMEANVNIGKLIVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIM2</accession>
    <name>A0A8H5GIM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIM2"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="424" mass="47571" checksum="C78A43C7C0DBC7BA" modified="2022-01-19" version="1">MSNAPINGVKISRTSLSSLFLAPRSPFSSPCRSANPLSLLVLLAIDHLSAAIDDPHKVVKVIASDGKSGETKEISYSNCKVIGNGSFGVVFQAKLVGATKENEDIAIKKNRELQIMRLVSHPNVVDLRAFFYSNGDKKDEIYLNLMLEYVPETVYRASRHYAKLKQPMPMLQIKLYMYQLLRSLAYIHSVGICHRDIKPQNLLLNPATGVLKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIKPHPFPKVFRPRTAPEAIDLVSKLLEYTPGARLSAVEAMVHPFFDELRTEGARMPNGKDFPPLFDFTREELSVRPDLIRRLVPSHCEPELASRNIQLDNFVPIPLEQMKITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ45</accession>
    <name>A0A8H5GJ45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_003216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ45"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="201"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1099" mass="126366" checksum="F4A187458E29B14D" modified="2022-01-19" version="1">MDPLDEKTNGGPSMEIDEIVSVRNHEAFAAKHMPDLGHDIKDFQVFSWRLENWKKLEKKLTSSEFECGGHKWRILLFPFGNSNAPPNDTVSVYLDYAEPKKAPEGWHACAQFALVISNIHDPTIYTVSHAHHRFIAEECDWGFTRFSELRKLFNTQDGNTRPTIEGEAADISVFVRVLEDPTGVLWHNFVNYDSKKETGFVGLKNQGATCYMNSLLQSLYCTRYFRKAVYQIPTEDDHPTESVPLALQRVFYHLQTSDQPVGTTELTKSFGWKSLDSFLQHDVQEFSRVLLDKVESKMKGTKAEGAVAKLFVGKMKSYIKCVNVEYESSRIEEFNDIQLNVKGMRNLYESFKDYVAVETLDGENKYQAEGFGLQDAKKGIVFQSFPPVLHLQLKRFEYDIQRDAMVKINDRHEFPFEIDLAEFLDASADRSKPWVYKLTGVLVHSGDLHGGHYFALIKPDRETRWLKFDDDRVTPVTDREVLEENYGGEPLNGLPPTLQRNQVRAMKRFTNAYMLVYIRECAMDEVLAPFTDEDTPSHLKRRLDEERLQIEAKKREREEQHLFLTAKVITDETFARHEGFDLATFDEKNWPPSDLPSFRVLKQETYSVFKARVAQHFNYPENQIRLWVLVNRQNKTVRPDTHIPENEPTLTVEVIRNNMAARQSDLRLYLDIIPDPSKPEPPPQSIMVFLKHFNTSKQTLLGVGKTYMLRTAKVGDLVPIINEKMGWTPGTALKLYEEIKPGMIEHMKPKLSFAQSEIQDGDVICFQVDIAEKEIHDLESQGLHSNPIHFYDFLQNRVMIIFRPKFEEPDHDHPEFNLVLSKKQNYDTMATRAGEYLRHDPIKLRFTTTHASNGTAKSVLKRSLNQSIAEIMAPYYTTSTVILYEKLDVSIVELETKRSLKVIWTGIHNKEEGVFPFLLPKTSPVHELADNLAKQVTLTPGGTGKIRIFEISRDGKTQKEFTGNEMIGNIPDPVELYAEEIPREELEADDADKVIGVFHFSKELSRTHGVPFKFVVKRGEKFVDTKKRLQARIGVSDKDLAKYRFALIQVSTFKQPSYIEDDDTIYEHQFAPEDVLGLDHVDKSGKTRTTGEKAIVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKR2</accession>
    <name>A0A8H5GKR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKR2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="66" mass="6968" checksum="9551395A3F0349CA" modified="2022-01-19" version="1">MFSPLSDLPSLNHSRVMRIVSERTEPMVETLVNGSPKLTCVGVVGSLSVTRDAASEPVAALTPVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKU4</accession>
    <name>A0A8H5GKU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKU4"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034242717" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="39976" checksum="C5DB579851AC9811" modified="2022-01-19" version="1">MVFVSSLLSAALAVASLVELTAAHRPPQPGSPEAVKRDLFQRNARRSLADCQDELSKRGGVYEKARARRANFARDARGTRGLSTGVPYKRATFEDYLKINHHSNETGITNNTDPATLFDGNSSCVLAPEVTEGPYYVTGEYVRFDVRENQSGIDHYTEVQFIDVSTCEPVPGIYVDFWHANATGVYAGVVINGNGAGENDATNINSTFLRGIQETDSDGVVQFLSVFPGHYQGRAIHTHIVAHQAGTQFPNGTFASANVSHIGQLFWDQSLISTVSALEPYSSNTQNLTLNADDMWAPEQADGIDPFPEYVFLGDDVTDGIFGWISIGIDTTSSYSIINAATLTEDGGVANAAGSFSGGGGGGMPSAMPSASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLI4</accession>
    <name>A0A8H5GLI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLI4"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="296"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="391" mass="42445" checksum="4DEA4C824EA4AF98" modified="2022-01-19" version="1">MSHRLLYRGALSVPDSDFLLDGLTFSARLDATRDLFENPLALALESMRRRPSLRLMGTVAVKVLHIDDSGEITVDIHPEATLSRVYFENLLCLEAPVEGEQVGLRVALGDTIGPETTQILIYLKLIPDHQQLENSTPIYALAVARILPGPPPSRPRAPRPDDPTPRKPPPVPFGFAGKQKPKPVPLRDLRRASSSSSLADLGSDVRLGTSSSSKGCGGEDVFKIPPLPVKNKDKGAGKGKQVNSGSKAVDVFGSISVNGIGSDGASASSSSGKRKRVEETAVDTGAKGETENSLERENKNRIKRAVLQELAEFPITKAHKDYKEVYNYVYRGVCFALRAEMISHPISQPPIDHFVKTHVKMYAYPSSSHVIQNGGGVVEEGAYESQDSQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM26</accession>
    <name>A0A8H5GM26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM26"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="769"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124325" checksum="D50EE72828E10B34" modified="2022-01-19" version="1">MDQDLKKQYDTYRSRIASIQDEDDPLAVYVEFVNWTIKNDDPNSELPRLLTEATKAFQKDARYSSDLRYLKLWIQYAHWGGYSPLSVFGYLYKHGIGKQYALLYEEYANVLEKGGKQTEANWVYLKGIENQARPLERLKSRYEEYRSRTASTSSKRPSKPTSSSSTHSTAESRYSVMLSPLPPGKREEELHFDMTLLYTPENGEYCIEEARTKSMGLLRKKWPILPPQPPARRGSAASSSSSSSSKDESRSDDPMDPNRTVAPRRKSLWAEPTVTINTREALNDVFGLYNSPTKTLKMGLGSKHAPVKEIEAVTSSSQIVKKPITAVNENESGFQPFVDENANVKKKENRPTQSAFTPFVDSEAKKKSGPAQRSAFSVKEVSTTRQNENDSYQAQTQFAPFVDPDSQNQAGPSRSARSAFAAKEVPTVRQKATENDSKGFPKVFSPEPRNEDVTENPPDYDPPKPKAVFSPFGDGSRAFKVFSRPSEADSLFVPKDLNGFSPLTDSKPTFTPFKDAEISAEPLAQKSDSSKPLAQAEGYEEEQSEDYSDDFDDDIPGDLEDEGDLPPGDEYQQQEEYDDEPSYREVPLGGRLGHFTPMTPITERTFEYTTTRSMQGSPGAHLRHIPENPDDEEMFVQEGNVEEEPAPENDEDSRRVPFKLVASRKDDSVVTALEQSTSRLTLAESLTLSSNFRPPNPCNPFDPPIISTLLSTRVHSDNHFFDLRDHECQKLDELQKFAKKSRKLSGTRSSGSSLDTPGSYSLNLSGQRFTVLEKLGEGGFGSVFKAKDQGSGPAEDEDSDFEDDDLDDEELSSIVALKVVKPRHLWEYHVLRRIHTALPQACRRSIILPHALYAFRDESYLVLDYCSQGSLLDIVNGAESAGVSQQGACLDELLVMFFTIELMRLLEAMHNSGFIHGDLKIDNCLLRLEELSPSEWASSYSPNGEQGWSSKGIKLIDFGRSIDTKLFPHGQQFIAEWETDEKDCVEIREGRPWTYQTDYFGLLSIVYCMFFGKYIQASALTKAGGRYKLATPLKRYWQTELWTRLFDLLLNPEMMRQDESLPITEELGEIKREMEGWLKANCNRTSGTLKGLLRKVEMYCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMI6</accession>
    <name>A0A8H5GMI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_003696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMI6"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="35"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5367380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="300" mass="32670" checksum="20C458DA1B6F0BA6" modified="2022-01-19" version="1">MSQDVTQTIPSAPGPSKLLTASYTHHSPTPTGNGPYILGVDEAGRGPVLGPLVYGVAYCPVSYKEQLDELGFADSKTLTPEIRSSLLETLQSDPSNLGWSVRVICPQDISSGMLKRPPINLNQQSQNATVSLIKDVLDKGIQLTEVYVDALGTTSKYEAYLSSKFPGIQFTVESKADNTYKIVGAASVAAKVTRDACLEGWTFEEEGYKAPDIELGSGYPSDPKTQAWLKCCLDPTFGFPKVVRFSWTTVKVLLEKEGHEVKWIDDGQASLRKAFESAQGLDKDRCVLTKELGIRNLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNJ1</accession>
    <name>A0A8H5GNJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNJ1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034757569" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="119"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="61504" checksum="1417D52F88356AE5" modified="2022-01-19" version="1">MKAVWWLALFASGVLGKPSKPRCRCLHGDPCWPTEYDFSQLQSTISQPLIHPVPPESACYPVSNPSGNCTDVQTNTFAGNWRSDQPGSMQIPQFESFIFPNGTIEACYLNTALGVPCRQGSVPPIGVDARSVKDIQAGVKFAVDHNLRLVIHNTGHDYLARSIARGAFMIWTHNLKNITPSSTFVPEGAPENETYHVLTLEAGVAWHEAYDAAQANGRVIVGGITPGGSVGTTGGWMQGGGHGILSPQHGLGVDNVVQLTIVTASGKHLTANSYLNSDLFWAVRGGGGGTYGVVTSVTYRTHEISPLTATAVFGNITPAVRKDILTEYLKLWPALSDAGWGAYLYLGMPGAAANFSLLLAAPDVPLADVNATLTPFLDFVRTAQEDMVIQMLPFDGFASFYQAFFADLDPQEGVNEELISRLIPREAFEDNEHLLDVMTSMDPILLFHVAGGKVAQVDPDSAGVNPAWRKATAFMISAALWPEGVTVDQYRAIQGQLKSNLAILDTLAPGGGTYLNEASLYEPNPQQTFFGDHYERLKAIKDTYDPRGLFIVAGGVASEDWDSSLNCRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPU6</accession>
    <name>A0A8H5GPU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPU6"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="37"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="913" mass="104446" checksum="F81A997C0F7CCB24" modified="2022-01-19" version="1">MAQDGEVRDLEKNDLPFSNVRERFKPTSDDDACFKLWNMYISQAQEYDKALIESWKSDMDGMLLFSALYSAVLAAFIIESYKNLQQGPASTTSDLLVQMSKQLALLSNGTVFTFEEPTSFHPTASSLACNFLWFLSLALALTCSLLATFVQQWTRDFLHKTTMRPSPVVQARVLAYSYFGLRRFGMHTFVDIIPILLHISLFFFFAGLVAFLLPVSFPLMCLMASVLAGFMLIYCGLSSIPLVFLDAPYRTPLSGFLWCYGNRLRGYIIRLHGLRGDLSLTEAMIEKSLQKSSGRDSQCMEYTMKQLNFDTELVPMFEAIPEAVLSPRGGVRLENFKLVASLIQSSEPENSIVSRISHFISISGTSSDPANQVRDMTYCLKALRSLALLVIQKPTQNDVDDTPMFWFDRSLLQVLAVSDTTLRDHITPAIALVRTSRLQSLKRCIDNVAQILSFPSTPAYEKLQLADNVFRCMSLDDIDWTSKMFLEHFTNLGNVLMKRISDDWQDHLDELVKEAQTSVSQLQSPGRWKAALISILGDFFFQIYHQWSEAHRDGIDEEEAAASFVLNNPSIIPSIVPPEMFILILRLFFSTDRAFSFHGSAKCRSIVQWYLHECQPRQRNYLVTQDVETHLEECILEDLRADESEYPTWCVTAIERLYAGLGFQYAIVPPRLRVFAKKIFDLIPNVSANFNRDRWWLVTKARTEWILCVDIYNYLYLSETSAMDASTLDDIRALGGRLMPDIPIPEQPDSPELNKQWVDDIRKYAISMVVFIISKFILMCSEDTGGVLLGDWVGMLNKLYRYEGQIYDSIQLQFAESIMGLISVVPWNQPKESAASQVFRDWIWRLNQDWVWITDLKSARILADAIRRHKNDVNFRGTLWQEQVLLDRCLHIIQDAEGEHEPQIPLIRVSSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ86</accession>
    <name>A0A8H5GQ86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ86"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="22913" checksum="65C855B9521DCB8D" modified="2022-01-19" version="1">MPEDECTQASLTLEGVSYFQGTAFVDGYINNFCALITMAGLNVEPVLYSMNPTAPTIKARLEDAKHVGQTVVLKFRCRLWPALEKKVAEAEACPQEWDIMAWYSLAKRFDKHEREDAIFCGAQRSMHPGPPKPTFPSYAQPQGCSLFPIQFPTPAVAPIPAPRVPAPTQAPLPQGIPMEVDASRQRFLACCTCYACGKTGHFSAACPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQT8</accession>
    <name>A0A8H5GQT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">D9758_002923</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5035032323" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035032324" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="63"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="507"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="796"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="805"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1104"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1249"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1249"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1248"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5369060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1293" mass="142014" checksum="A9C1A636AE53C9FD" modified="2022-01-19" version="1">MPPNASKIKSAFKYVSGRRSGGDVNASNDEGVSNNTANPQSGKKTRKLPGNGVGRSRGTKGFRRNRLQPMENEQPVVMLRVQVVGCKDLLAKDRNGFSDPFLHVTLLPTRHVTPVAKRTLNPSYPEKESTFDFPIYLSLADRLGVLELVVWDKDLLRKDYLGEGGILVSDWFKDGLTLEWNAQSDVISIPLVSTRTNTPNQGSVQVRIGFIAPFGGTIFTSDGVGTVRSHVSSTAGDATPAHQHEGFEDDGGISSDSEDDDDTATETETDDDDEADEDEEFSEGVEDTEMLTTPVASPSTSSELTTPTAMSPSSSFLEKTSSTFSSLYSPSSSPTPDKSPRATTPPPQLNLTPASPSVKEAESPLPSPSVTAPATTSKSPKGILPRMFPRRSNSAQSSPAEQGEVDLTEDVKGLRTSPQSPTTEKAEEKEKKKRFRKSWTSSRRSSASSSPDTRARGKTTSDIVSPIPLSASGRSVSTSSGILSTPGSLAPTDAVTKKRPGLKKRAKGGYSFVGGGNNDIVGIVMLEIQSASDLPKLRNITRTGWDMDPFVVISFGKKVFRTRVIRHSLNPVWDEKLLFHVRRYETTFKIQLSVLDWDKLSSNDYICNTMFDVKELVDSAPQPDKETGLYPMEDSEHVSEMKEYTLDLKPEKVVGWESKHKPAIRFKAKYQPYDALRQRFWQQYLQQYDTDDTGFLSHLELTSMLDSLGSTLTNATINSFFTRFGKDPQKDELLITEAIQCLETELGRPDSEKKRLDQDNPEDTSVSATPLIMAADSRGNEVPLDQLNFAGPTMQGMTKYEGDVPAPTAYPAPYSSQSPLHSQQSSSNSSAGLGASTPASEDSSTAPPSSSPSDVEEDSSGSSPWNSGINEPTVPESSSKKKTKFKRNKKQKKPSGSSSSTSVVDDSVERVINVKNCPLCHRPRLSSKAEVDIVTHLAVCASQDWNKVDRIVVGNFVTASQAQRKWYTKILSKVSSGDYKLGANSANIIVQNRTTGQLEEEKMQVYVRLGIRLLYKGMKSRMEGGRARRLLKSLSIKQGLKYDDPESARDIPAFIEFHGLNMDEVLEPVENFKNFNEFFYRKLKPSARPAEQPDNPYRLVSAADCRFMAFETVNQATRLWIKGREFSVARLLGDAYKDQAERYNGGALCIFRLAPQDYHRFHSPVDGTIGPMTYISGEYYTVNPQAIRTALDVYGENARKIVPIDSPQFGRVMAVCIGAMMVGTIVTTVEEGQTIKRGEEFGYFAFGGSTIVVLLEPGVVQWDEDLLINGQASLETLVRVGMGIGNGLRKPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRB4</accession>
    <name>A0A8H5GRB4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRB4"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="191" mass="22244" checksum="B4A8DF6F428807A5" modified="2022-01-19" version="1">MSNDISTPLTHDFPEVAHLSRQDLEDLLSDHTYFQAIFHSLPRVKAMYDAQAELGMANESIANNNLALQGKLYELRTDTKAAFDEAKSLEARWRDLEKEQKDVYQRFTPEFLHWRLQQSISEQDEATEAMASAFIQQDSSHTSEGGSGTATPSGREIDDFIREFKKSRKIYHKRVMWNDRWKKGQVEWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT32</accession>
    <name>A0A8H5GT32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT32"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="24068" checksum="4F64635BCA9CC91C" modified="2022-01-19" version="1">MPSVRWDHLSILNVADSLPGKVEAELARLNGSGVINAVVSASDDVVTFLFGAQTVIKNFSPTLFGNRSNPATNANDKATGSHVSIIMCKRDFDLTRGEWFLLHYSLEGIMMKLGPKAAYGLASSEPSFTPQRPQSISVRGRGTVQREIHGTLISDEHNIGRAGSVVEFMFILADVESLFSSTHYLEDAIDSNVSSHHLDGGMYQVVPMWNGASSLANEEQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUA2</accession>
    <name>A0A8H5GUA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUA2"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="429" mass="49071" checksum="4BBEFD2E677B3A7B" modified="2022-01-19" version="1">MATETEVRVSTSGRRQDTGAKFNPFKFRRNPDQVKVNDADWYKVWEETESSRRVNYNEMEHQIDRLDSATKDFLMGRPWPSGPCSSLWGPRNSTERYLVIVPRLWRFYINYLLRNRVFPDQEHEEGFRQALQYVELAAEELPKISEISKALPDGLSKALDECFQIQTQTFRLKAKENGWNDDQNASQSADTNDRGDWNHHESPDTSPEFSPSDLSSWCSSEPDMLMKYLGPTLFPLTHTSGVVEESVRRIKSVIPPSESKCSPSSDSEVQAIQVEMELKRRFSKVVLSPWLGWEKPEGKVSAYNDQHIPRIQKLSRGKVIVEKGSMMFDGLNEKDVVIEEAAAEQPGNEPKPHDPLKDDITILLEPSTAEKFKVGMGIGALWVRIARRADLEVEALDITTVSSKTRTLKKRYWFVDGSVFAVLTSYYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWY5</accession>
    <name>A0A8H5GWY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWY5"/>
    <dbReference type="OrthoDB" id="3247165at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="638"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="704" mass="80678" checksum="2860E04F2D73AC68" modified="2022-01-19" version="1">MPVMIRYNSATELCITKGQEGYVHGWKAKTGKHGKLVLDVLFIKLHKPPNPPAPIKFDGLPENVVPITRNTVRIECKLSDDSEIAISRTQVEILPNFAMTDFASQGKTRDWNVVDIHNSRDFRAIYTALSRSSCADQTLILQGFNTNLLTGGIKNKGGYRQELRELELLDEITRLKYLGILSPSVFGDRRSSLIKSFRTVQGINFVPASVHKSIEWNDSDPLPDTFDSGETWQIISADNETDQKNKRQLKGNFKTAKGATQNETKGRTLKRKAQAEESERPSTTPKKKIKEDVPAQIQRNSASYLSYPSLRWFLNSCAYDSAIILLYYLYVNHFEIEMSHFTQILSMDLLDAFRSGITDLTAARENVRRGLHNIDSEAFFYGQYADAGEVLLALTQSDLSFSRSQVICTNNHVHKPWKNRTNMLLYMSTRMYQSTQQWVDNFVQPFGWQCQICHTELQTVIEFTRFPKFFLLYVPINASMEIDRMINLTVNGNQKPYDLKAIIYFGEEHFILRIFSNQAEYIYDGIKKWTTFGSDDLVEGNTTIVSTNITESPSKTDLLGRDENQTHKEARINELREQYSKDLGRVKFWKDPSMIDIPVGKPRPFLIRRYGNPPSPVSQCKKRIDQLADTLYDSNLRCEALSLNLQAASYALESAERERDRAVEEHTKLRKEVVGLHCELRRLQDRIKTGGWDLIRLSDSVDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX27</accession>
    <name>A0A8H5GX27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX27"/>
    <dbReference type="OrthoDB" id="2747447at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="647" mass="70373" checksum="866611C4CE178444" modified="2022-01-19" version="1">MGPVPSELLQLISTGADADNTAEGSSDITDIVSNFQDLSAVLSLFAADTVESKFSSPSADDWERMSTAWSIFGIIGAVRAYLKLVIGLDAAEKAGLELYDLGGYTSRRTKEAQCTSLIGSKEAAIAWQDDRLTLLGEVNTNHSSPRWKRPFMIVIGYSRCPFEGAKASREIIGLTISGVVTLIITCIPLLVIRTSVRGDTIDNVTLACKIASSLVSGFLLPILLQALNNVGVACLRDLPLDRFDGLLKDGDTVDTTRKVTDGLLKDEDTVDTARKAINGLLKDGDTVITTRTASVIFWQSPGQGLRPRSGDLMSIRLVATLATITTLASYILNYIELGRATTWRAYTWLGIQATILVVRFVLWALQPAFLSHRERSVVFAMAGSLDEPLLPDAEESVGKLHRDVVRFAAASATSSLLNKGGNIAKLDLDALDILSDVAPADILVAKYCDFEALMRMGGEMRAIRLPWSWMEEIYAGQGLILGNNPWAIGGLYLAAVVQRADGESPWSFKGLTTIHQKGTSSNGAHGEDSLDWFAKKDAALQDVKGVTANNYGVSSLVNGEILAKMPYEHDVMTWHEEFRENVRICRASAVSNGPPHQELHVCQAGTKRMSKMVASLKDVLKSAYEIVAKEKDKDHSECRDFCTVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXY5</accession>
    <name>A0A8H5GXY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXY5"/>
    <dbReference type="OrthoDB" id="3049395at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="712" mass="79656" checksum="40904AD9F2F3E78F" modified="2022-01-19" version="1">MSLSELYNYLLHQHNARAQNQPCVSAPSIFPILNQPITIADIEELKSTLSAHPHSNTSGVNDCTYSLILKLDNNVLCDLYCQCFRTGNVPTAWLITLLSALPKQGKDLSDPNNHCAIALESCFLEFGTLLILQLLTKAAEMGNLIPPTQNGFHAGHCTHNNAFILHLLIECARENNETLYVAFVDISNAFPSTNHNTLWNRLEDLGLTGMYYDWLRSLYSNMHYRLVLGNESSNNFESSSGVLMGDPASPMLWNLYLSTFSLPPHKHDISLNGTTISHLEHADDMPLEVGSHDIWGCPPRVTELSIIDYIVGTFDPSPPCFIVNGHTLLITDCFKYVSVTFCSVKNDIFAVVYDKKSKAATVSSHGILSTECLVGRGHLPPKSAKQLYTMLINCHLIFGCEVVLDITNSAIHHLEKIQHTFFCCILSLSDNSILTPLYTETGICPIRVCHAVLALSYLRYSLELPHNKLAHVALQSLLLLCSCNTPCWLSDLNYVIHHLPHPPDKSPLSLPPNESLTPSNVTDLIKQVNSSSSSFLLGQINDFSHLSLLCSRFKPVDPDSDSTPSSPVIFFCHYLHRVPKHHHCKSLTHLLCGNISPWVFRCSPGRTHCDGDDILSMMCQFCNTSYKTPEHVLIQCNHVPQITYIHSTFLSSMNLDPLTSQSNGHALELLKCWIFDWDLVAATTAFIHNVFIIWKDRCGIPRIDELWSDERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1M6</accession>
    <name>A0A8H5H1M6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_000283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1M6"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5375032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="41330" checksum="54A977CAAD158128" modified="2022-01-19" version="1">MQEIPRIHTRPSQLTALFRDTRWGGVNYTPQISASYRLAPAQSPLCMVCASSPEHNVTKIKTSALSLLQNAKLEKSRVFEVGAKTLCSQTTMAPLADFLLAHVPFSLPPHLHSYIPGKTPLSTTPTVLSALISYLVVIFGIQAAMKNQPPRKLNALFQVHNVILSSGSLLLLVLMMEEIVPIIWKEGIFDGMCAPPSWTERMEFYYMINYYFKYLELLDTVFLAFKKKPLGLVLARISSFRHRTPLLLPIEWENEYYYYYYATAGGAKIWWKKYLTMMQIIQFVIDLFVVYFGSYNHFATAYTNLPTVGDCAGSEDAALFGCGLLTSYLFLFINFYFQTYKKKPQANGKANGKANGHANGKVTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLG6</accession>
    <name>A0A8H5LLG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLG6"/>
    <dbReference type="OrthoDB" id="3258419at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="128" mass="14858" checksum="06C5B4E94BCEFE49" modified="2022-01-19" version="1">MANCYDIILHHVIPPQEVLDLLTETFPQKWLDGDAKSIADPRYNHGRDLMPVKVLHLWKEVARAVRIQKEWREAYQTVENAVQSPEVSRYYLSAAAVFGQRGWDEGITIDETFTTYTFSHSRNYCDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPV8</accession>
    <name>A0A8H5LPV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPV8"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5365600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="325" mass="35913" checksum="5BA5B188673C331B" modified="2022-01-19" version="1">MADVGRKYQTTRTFSLGLWFRLHGVDLITMALMGALGLGIYEAPPAPSRSFPVYFQDGEVVYPEFAYPLRHEIVPIFAAALIAFFAPFFFICLFQARLRSANHFLTTTMGVLKSLVTAAVFQVWVKWLIGGLRPHFLTVCQPNIQPNSAPSGNGFASIMYDRTICTGDKDQIDDSLESFPSGHSTAGWAGLLFLALYINAQLKVMSAHNPSYWKMILMFAPILGATLISGALTIDEFHNWYDVLAGAIIGSSAALVAYRQTFAAILDWRLNHILLPRTTSLFMRRPRYGAECPFGTANVPFTREGEWGLETSRNPNGANANANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQP4</accession>
    <name>A0A8H5LQP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQP4"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="311" mass="34236" checksum="EC18CCE3F3E5D734" modified="2022-01-19" version="1">MSSTPATQLKFVATSAVFDLDGTLTDSTAEVAVTSSSYNSNVATPALTPNDSPASSRRSSISSISSVSSRPRRPSFATELQKSLFELSLKDRAEARIAESTPVRRRPGARVLLESLPTEKYAVLSFGSLDYVHDCMFRAGLPCPKYTVTAEDSIAEVGVFSLAAQRMDFATPGRCAVFVNSPEGIREAIAEGAGTVIGVCGTYSREQLEQEQLHYVVDNLEAVRCTVLQSGELEFHVWPPKRVPVPESVPEKKPPVKTKMLPKLRTRDMWEDMLRSRTLSPLSPSPLPRRQSAFIDSLPEWLRNADVWDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR78</accession>
    <name>A0A8H5LR78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_003982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="847"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="934"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="180"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="520"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="814"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5366995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1399" mass="156527" checksum="8BC87465B9204554" modified="2022-01-19" version="1">MARFDKISPKDDEEKVQDPVSQSRVDADVDISVNKSSWRNLLIFSRNPPPPPKLSVEDAELVPEATAGPFDIITFSWLTPLLSLGYQRPLEDSDLYKLQDERNAAHIGGIILESFDRRRKNASDYNERLARGDISPGWRSMWWTLKGNRETREKEWREKTGRKKASLVWAMNDSVKWFFWTGGIFKVIGDTAQITSPLLVKAIIKFATESYTNHREGRPTPPVGQGIGMAFGLLALTLLSSLCTHHFFYRGAGTGVLLRGGLIAAIYSRSMRLTARARSKLPNAQIMNHISTDVSRIDFCAGFFHMFWAAPIQMIICLILLILNLGPSALAGFAFFVLASPLQTWTMKKMFSYRLKSMAWTDKRAKLLQELLSGMRIIKFFAWEIPFLNRLADIRRRELKHVCPRSSPPACRKQCCSDVLTSSCFGPVICHIFTGWASAQSSRYLCLLDPFQSAQIAFDDAASLSDAYSATQRLYAVFEAETLDVTRIIDDTLDVAIEVKAAAFTWDAPPPEPTTGKKGKKSKKTAKPTSSDEFKSVEPFRMRDISLTIPRGQLVAIVGQVGAGKSSLLQGIIGEMRRTSGTVKFGGSVGYCPQSAWIQNATIRQNICFGRPFEEARYWKAVKDSCLEPDLDMLPYGDMTEVGEKGVSLSGGQKQRLSICRAIYCDTDIQIFDDPLSALDAHVGKAVFHNVLRDAMAGKTRVLVTHALHFLPQVDYIYVVSDGRILERGTYTELMENGQQFSAFVREFGSKDGEGEQSKEEDSVVDEKAEDEVKKKFTTGAAIMQAEERNTGAVDMAVYKQYSEAARGNIILPFLVFSLVLVQGSTVMSSYWLVWWQENEWPQPQGFYMGIYAALGVIQALSMFLMGSTFALMTYFASQSLHKSAIGRVMKAPMSFFETTPLGRIMNRFSKDIDTIDNMLGDSFRMLVATSSNILGAIILVSVILPWFLIAVVVIMSVYIYAAHFYRASARELKRLDAILRSSLYSHFSESLSGLTTIRAHGETERFRLDNEKRIDIENRAYWLTVTNQRWLGIRLDFLGMLLTFTVSLLTIGTRFSISPSQTGVVLSYILSIQQAFGWLVRQSAEVENNMNAVERVVHYGQHIEQEAPHELPDSKPPAPWPSQGRIEFKDVVLRYRPELPPVLKGISLNVKAGEKIGIVGRTGAGKSSLMTAIFRLVELDSGYIKIDDVDISKVGLTDLRSGLSIIPQDPLLFSGTLRSNLDPFNLHDDAKLWDALKRSYLVENEKRVSLLSTATDESIPSGSHTPVNRFTLDSVVEDEGGNLSIGQRSLVSLARALVKDTKILILDEATASVDYETDRKIQDTIAQEFTDRTILCIAHRLRTIIGYDRICVLDAGQVAEFDTPTQLFEQNGIFKGMCDRSSITLDDIRLSRKLSMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRY1</accession>
    <name>A0A8H5LRY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBA4</name>
        <name evidence="13" type="ORF">D9758_004067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRY1"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="326"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="11">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="11">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5367194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="420" mass="45598" checksum="1B2A3EF0A76846E0" modified="2022-01-19" version="1">METTLALDEYRRYGRQMILDGFGLEGGFRSQLKLKRASVIVVGAGGLGCPALQYLAASGIGKIGIIDHDVVELSNLQRQVLHNEQTLDMPKAQSAALALKRLPFLPLWIETRQDAECIYRLDSNANVEIITQALAPDNAIVLLSPYDIILDCTDNPPTRYLLSDTAVALGKPLVSGAAQKFEGQLCIYNFGPTGPCYRCLFPKPPAPEHAGTCEETGILGAVTGIIGNLQALETIKIIIGLHDGTPSLLLFSALGIPPFRTIKLRSRKPTCPACGEEGQKLGEISNIDYVQFCGGAAPDWEKSGLVEGSPDRRISVKDLKMTMDDNTVKKRIIDVRSATEFGICHLPDSTNVPLKILVSDPHAYLPDAETPTYIVCRLGNDSQIAADALQSVCPEKFTVKDVIGGLRAWSKHVDVNFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSM1</accession>
    <name>A0A8H5LSM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="864"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="916"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="453"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1279"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1348"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1387"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1406"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5368510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1574" mass="169981" checksum="698ED59237616314" modified="2022-01-19" version="1">MASSTMPAVLPDASSSSTMNTVYSLSLLSEYNHTLDSLPLDLSRHFADLRELDAVLSSSMASITAKITRLTQMIEDNVGQKDERLWLLSEIAEEASRLKPGGEDKIRVGCQAADALKGHFSHLKALSEHIPEFDAMTLNRHTTYPHVAAKSFMPPHLFESGRRRRTGFGSLLTSAADPSPAKRKRVVRDDDGDIKTPRKEKVIEGVSRARNGARAKKVDRAASPTESVLSVTSHITSQQAQNIASSSRGTSNHATSRAANGMNGVSGTNKRARNTGNRAMSPPQHDVYPNGALYDQPKTNHANSSTNSRRGEVFNVPPSSSHPSLPLPFNANGHPSTNGFSSNSISNDSTGSSKEWSGNRNQLEGPGMPVVRSQAMNGGNANGSNAATSSPAPNGAGPLTDAGTEGGDGDADGDGDDGAVYCMCGRGSFGVMIACDGAACPGEWFHISCIGLSSPPQGDWYCDSSREFSYSPYSKFRVGAALLAADGSIIKGANIENASYGGTICGERTAIVKAASEGKRSFAALAVVTLNRFTRLAQGRWWLWRCLPVCADPSYVHVHHEIAMTFGGSKFPGALGAMLIEVLPFLRGIASDIRSALGDGNPALVPTVFAGYALSSFLIGVVFILLGLLRLGKLVAYFPQTVLTGAIGAIGVSLFILGLGLNLPENSPDLSLSNTRSLLFNRQHLPLLAASFFPALFLSCSVRSKKINRWTQGAVQNAYYVPIYLSLIPVLFWVVVGPQHLDQDMLIREGWLFHVDSSIREEGGLGTAWIYWKQFDFGQVQWWAMRNAIENIVLLVVIGVLNLPIYVPTLAFSLDVSYDMDYELLGQGVANILAGAAGTMPNILQYSYSVFFTRANGGRFEAGLVTLLTFILFLTSGLLLPYVPTILASTLVLFLGIELTLEAMWESAKTLLPMEYAVVVGTLVACTFIGFAEGFGVGIGAAAAIYFVYGVADTRAREIKWERWTEMYAPHSGVPSLNTGTTPVVTTVDVENGVSLDVLPDFDSSDETVGVLVLSGYVFFASIPSIESRILKLKRTASFIVIDMTTVHRLETAAAQCFSRAVRDLGDATTLVICGLEKDSPVEADFQRAGVNLIYGDGPLEGKGIRVFLNRSEAVRWCQAQQISKPAASKTEDPSAIFSTFCDFFGFDAAKHPDEAESVQAPSPSRTNGFDRAGLQFCFYDAGETISHPSSECILFVVEGRVDAISRGEDLSASTNRHSGRNSLGQTLRLLPRDALRFARERFATPTLRRLAPGAIARVESETKLAAREKCVTAVIAEGQSSTALPSRPRAGQDRTPSPTSKVPSKFDMIILKNGDKISPDELPVPYLLTDAKNLEWLREKEEEIDAKAATGAKKSTNPKGKSKRGRKAVENNDGDSGEGASGASKTSKETSAKHARADDNDDKAGSSAPAKKAAKTSSSSKKSPEPIDLFSIYLDGDEEGTVEIYDSCDELRRKINKHLTKSGTTKAQFMRDIARAAYPFQDPPPKIQTKQLSDFLIKAGPTAGSTSRVFYAGYVYFEKKRLSEGKPKSEHREMMEDEWVDGIPRERPGQAYIIPVGYELYQTETGAMRTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUH3</accession>
    <name>A0A8H5LUH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUH3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5369786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56619" checksum="FD7C90FB7C4799A1" modified="2022-01-19" version="1">MPVSVVTFLDLCLAVLGLYLLKRLLETRHKLPPGPKGYPVVGNLLDMPTENSWSIFGQWGDMYGDICSVTVLGQTFVILNSATAAFEILDRKSSIYSDRPVMPFGGELVGWKNTLVLLPYGDRFRRYRKLFHSLIGSQATMKQYYPAEELETKRFLRRILMKPDDLQRHIRKTAGAVILRISHGYEVKESNDPFVQLADLATEQFSVATAPGQFLVDSIPALRHVPDWFPGAGFKRTAKAWASTLLEMVEQPHSFVKQQIASGTATKSFSSSFLESKQLTEEEEFDLKWSAASLYSGAADTIVSAIYTFFLAMTLYPEVARKAQAEIDSVVGNDRLPTFADRPHLPFLEAVVKETFRWNVVTPLAVPHRASQDDYHNGFYIPKGALVIPNIWKMTHDERMYSNPMEFKPERFLSVDGHTPEPEPSATVFGFGRRICPGMHLADVSVFISCAMSLAVFDITKSVENGIVIEPVNERTNGTISHPKQFQCTVKPRSLKAATLIQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUQ3</accession>
    <name>A0A8H5LUQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUQ3"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="505" mass="55053" checksum="F74931ED7411A211" modified="2022-01-19" version="1">MNFANVQTILKLPRRQTDEQQIPLLTVLSRLTWLQWSHFISGFLSWSCDAMDFYSVSLSLTSLSTKFGKDTHEITTAITLSLLLRTIGAIIFGFLSDRFGRKWPLVSNLLFVTILELGTSFVQTYDQFLAVRALFGIGMGGIWGLASSTALENLPVEVRGLASGVLQEGYALGCILAGVVNLSLVPEKQEQLGVDSWRALFWVASGISFFTAVFTMVIPESRVFVRAKRETEGIGAMQRTRVFVEETRKMVQLHWKVFIYAFLLMTGFTFISHGSQDLYPTFLQQSKGFSVRDASLATIIGFCGAIVGGAFAGWISQYIGRRLTLIFYMILTGAVIPLWILPTSFAALSAGAFMIQFAAQGSGGVPYQVIVNAPPQIPIQLSEVSPPAFRASFSGIAYQLGSMVSSASAQIEATGGDNLRVFLSKSDGTFANVPDYGTVQGILIGVTAAFVLIVTLLGPENHGSHFERYKAAFEEGGGEDAVAERESASVDEVDQQYKEKGLMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUW5</accession>
    <name>A0A8H5LUW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_006896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUW5"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40729" checksum="C4776100E9312591" modified="2022-01-19" version="1">MSSLYGDYACTPTLKRVFYGPGCLSTALPRLLEILQVKKALIVTGNTLRTKTDVVERIENILKEHNAFGGVFHDIHQHVPVAGINNGAQAFKDYGADFIVSVGGGSPIDASKAILHKIWKERGTSEPPVQVAIPTTLGAAEYTYGAGFTNEAGVKVGVNDPLLTPAGVVLDASLTLATPERLWLSTGIRAVDHCVENLTRNLYPLLLKPLCYAALADFFKYLPITKAEPQNVEVRQRLQLAAMMSLWPLQQDKFTVLGLSHLLGHRLGAAYNIGHGITSCITLPAVLALQAEIATPEMKQCLADCLFYLREPSTGSVEGDIRKLSELIAQLIVDLGLKSTMSEYHVPREDIPKLAGNSEDPNYPKIVRVLESVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV69</accession>
    <name>A0A8H5LV69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV69"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="24507" checksum="C385C7085B2CF05E" modified="2022-01-19" version="1">MVYGCVGQEEFHHYCKLRLNAHVHDEPLSEATLSQLISQRGPCPRDHHRPLDFLTAEIQQAIRLFDKIFIMRASLDHCNYKVDFKMLEIKHMLLQQYDDETLDVKAYYKWFIDTTMEHSDLVGSLFPMTETSPRVFVWESSHEARAFPSPFANSTVAYLNSMDNYDFAHDFQNRIAGLYYVPTSSRNPLFNAFFSQLSYTGTLTIWVVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ81</accession>
    <name>A0A8H5LZ81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ81"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24712" checksum="7FB7908C95994B70" modified="2022-01-19" version="1">MFAFVLLVFTNLRVQKRFHTMLKIEKDLAAYDEDATLSVDLLMSLTNCNGRIAGVFLHINFESILRYSHRKATGMCLGGHLAFRAAFDPRVLSSVCFFATDIHSATLGKGKKDDSLERVRKGELTGKGELVMIFGKQDTHVPRAGRDLIRQTLEDANVTVSYLEVQAQHAFIRDESSKDRWDAALTRSCFSFMLEVFERTVGRDLGPRVDNTKPPQHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZF0</accession>
    <name>A0A8H5LZF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZF0"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5375187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29434" checksum="BBE1CAC651A39355" modified="2022-01-19" version="1">MSKVVLITGGSRGIGKMARIFSKRLKLTFHESFNQISTGFIRNGAKVYISSRSAEDCEATAAELTALGPGVCVAIPADLQKYEEVERLAKELATKEEALHVLVNNAGAAWGASIDDFPDAGFSKIITLNLQRVFTLTQKVLPLLRAAADKSKEGAIYADPARIINIGSVEGLSVPPHETYSYSASKAALHHLSRHLASRLGSEGILSNTIACGLFPSKMTAHTIKTAGDVIISRTIPLQRAGKPEDVAGTALFLASPAGSFVTGATITVDGGFLVASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZG2</accession>
    <name>A0A8H5LZG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_000493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 10"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZG2"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5375217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="42401" checksum="92512F89FE6682F6" modified="2022-01-19" version="1">MSFVKLSIFGTSFEVTTRYVDLQPVGMGAFGLVCSSKDQLTGSSVAIKKIMKPFSTAVLSKRTYRELKLLKHIQHENIISLSDVFISPLEDLYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEGKPLFPGKDHVDQFSIITQLLGTPPDDVIETIASENTLRFVQSLPKRERVPFSQKLRTTDADALDLLERMLVFDPRKRIDATESLSHEYVAPYHDPTDEPEAEEKFDWSFNDADLPVDTWKVMMYSEILDFHRVGQNSVNMNEGVPEGALAGSEGAEEVAIPATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BAS9</accession>
    <name>A0A8H5BAS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000423">
        <property type="protein sequence ID" value="KAF5319879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BAS9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5319879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="369" mass="39887" checksum="5914CB683BD3D780" modified="2022-01-19" version="1">MSFWSRDETNSSQTPPPTWSDRKKSRFLTRQTEDETAINPSSSSSPWVGSIRHPFVEASSTFPYTYTSDTTPSNPVSIGSAIPSPTLATSTTSVLPKSTTRVPESRLRSTATDAYAQSNPQGLLSRNPSSHQSVLQKLLGTLALCTVFLPVFPLLATTYMVLGHSILRAAHHHSDSTPNPTSYHAVPLSSSAKSGAVGGIILALPILILLYPFLHSTPIFISFSLPTPAHVIQSVSQTNSSRPDDFFDDESEKRVVVFGRRRSTRRHQHHHGQDGQYGHHRDEGASKTMRTIGFAVLFILVFLFGSISGPLGYGCLHAANDGRYNSQTMLSGRHAAEAGLVGGVVLGSVLVGMGLGLAILARSYFVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BDU7</accession>
    <name>A0A8H5BDU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000412">
        <property type="protein sequence ID" value="KAF5320377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BDU7"/>
    <dbReference type="OrthoDB" id="3051833at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5320377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="439" mass="48107" checksum="878E5F2F52C0657C" modified="2022-01-19" version="1">MSYGPFARALNHFSSTAPGLLDLLTGVDVEPTTGRNGKLWKTWNGRRNGAVDFILTRLDDSVLGHANEYQEDPAGLWRHLHAVFGDSGVGGGVRAWRRFAAVRFTGWDFQMSTVTGKIRGIADELERIIATMLSACAAFSEFRPIIASLESSKESLKVDDVELQLIRAAKDFTEERGQLNGGAIIPGDQTQALATTMGARPICTNPKCGQVGHTIENCFHEGGGKEGQFPDWYFKNCRKEETGPAVNNAMATFALHLLPGLVVLNTTKAHEISDTTLGKDISDGFTVASIALSLASLAKKVVASIKVDMSSSSDSLEGVALLICSLQLATSKSRHSKGHQAWTWEDHYHLLNQSVCVRETSYDWKYFVDPCEVALGLSTDGFAPFKKWSKTAWPILLVNYNLPPDVHCHLKHILSLGVIPGPTKPHDWDLFLWPLMASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZD8</accession>
    <name>A0A8H5BZD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000309">
        <property type="protein sequence ID" value="KAF5332372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZD8"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034470359" description="Glycoside hydrolase family 71 protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54211" checksum="318EA7CDEFAFF108" modified="2022-01-19" version="1">MRPQLLSLLFSLSAVCVGTRASVILSRASDASGSGKLVFCHFMIGIVSDRSSSYAYDADMTRAKAAGIDAFALNIGTDGYTDQQLQYAYDSAARNNMKVFLSFDFNWYSLYGSIPQIAGLINKYSSYPSQLRVDNKIFVSSFVGDGVDVNAIRRSVSSPLYFAPNFHPGQADFSQLDGAFSWQAWQTNGQNRAPSNGQLVTIDSEDKSYVNALQGKGYIAPASPWFSTHYGREVSYSKNWVFPGDLLWYNRWFEILALKPRFVEMITWNDYGESHYIGPLSSPHYDDGNSKWVNDMPHNGWLDMAKPFIAAYKAGASSPNSYIKSDQIIYWYRTTPKNLNCDSTDTVPGIPDGFNTMSDNIFIVTLLMSPGTITVQTGAMVYKFKAPSGASAFSVPFQVGAQTFTLTRNGKKVQGMSATSLKEIKNQCTCGIYNFNAYVGTVPEGTRDDLQPDGLAGFSNGLRTGCQPTPSLPPSPPPTVAATATSSVGSVTPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0S0</accession>
    <name>A0A8H5C0S0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0S0"/>
    <dbReference type="OrthoDB" id="2988151at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="265" mass="27256" checksum="0A54F500CEB043A3" modified="2022-01-19" version="1">MTMTTNSKPKSGTVDSLDSQNDVPPPAYSETQPIATPGFGSSSPAAASGFASGSTSASMPASTPTPTPPVLDPYNPYNNPFNNPWQSTSSTPSASVLGSSSGPGPRQPLLTSPSPHSHQQSHSPHSYSHTDMPQFPNYPRYDGTVTGGGIGAGAGLNVPPGINVNPWQNGPGTGPGGHGAFGPTPTQHLHNQGIPYAYYDPRSEHSIVQADARARKRFVGAVAWVLCVGVLVGLLVRGYCMGYFDDLGKMPPLPGWPGGPGAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4U5</accession>
    <name>A0A8H5C4U5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4U5"/>
    <dbReference type="OrthoDB" id="3049395at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="33453" checksum="BB16FCDDE282279C" modified="2022-01-19" version="1">MAEALGMTGSAQVMDLSVNDGNNYTPTYAIYKNDIPVCMALINFRADKSGTSAYTVSISISGGDTGQPASTPSSIKVKYLSASSVSQKANFTWAGQTSDGRPMGEEYIQTIQCDLTSNTCQILVPTPSFALVFLNDKPLEESMDGGNGEGGEVTMYSTTAVTKTMNTAKIDQEVLATSNGHWAGDLPHNSDISVSNIEAVKAYLSLHPHSSTCGIHDTPYSLILNLDNSDLCQLYWESLLKHGKDLSHPDNYCAIALESCFLKFGILIVLHKLTKAAEDGNLIPASQNGFCAGHCTQNNAFILRSLIKCAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5E1</accession>
    <name>A0A8H5C5E1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000239">
        <property type="protein sequence ID" value="KAF5335595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5E1"/>
    <dbReference type="OrthoDB" id="3027821at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="287" mass="30204" checksum="E3935892EF5E31FB" modified="2022-01-19" version="1">MFFLYFSTLATFQHLDKLGGAALQQSQHQQLPHDDDRTNRFTDPSNIPHQRAASQPPRSSSDQPFLSSPTIPSRSPWSSQHRLLSPIQPVGGIPVPMSSRSASFSHQPSSASTSSSYFASAMRDRQFASTFEDDESEELADDPSAMIGRLTASAYDDGGYDDETFGTEPSSYNPPRPIGGGRLPPSLSSSISPSMLSTPANPMSRGRTYAPDLSRSRSQSLATATVARPLPIGAGASYGGAGGGGGYGGYGSAISSWNGDEGYLSGAMGMGGGRFGDIKPPGRLVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5N9</accession>
    <name>A0A8H5C5N9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000241">
        <property type="protein sequence ID" value="KAF5335448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3056576at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="3">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1900"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="667"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1838"/>
            <end position="1870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5335448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1995" mass="223596" checksum="05280AA90115BDA5" modified="2022-01-19" version="1">MASRKKQLLKSQGDMITVSRGGSHIARTISVSASGSTHVAFASELPASGSSHATPTPQPVDDGLAAGHEDTRQQKKKKKSKKKRRHCEIEQQYQPRFPDILDRLIERSYNQRIVCQQCFLDTHERNLFFHWVLEWDVGNGYFVKKDLSTIGGCLKFCQRGDLGCSRDENNHAVQLIVAEPNRIHSSLARFCRCGNQSRWDQLFGLDMFPATLEAPAMAFNFECLRHFDILTKTSRKAAYDYCLYLQRITDNMFPTNISDVYDNFLIITRVWQTLMVEKWLGQGHGIDDVLPCRPKGNVVLYCPMCNERGVNMEEGCENDLDFLKHLSQNKNTTDGNFQANHYAKNRDSDDRSFFQGQSFFPSQEEVDKYKSTVPQLQSLKHKVDCEWIKAIAKQNLKKFRGMDITGILSRQCDHVFVEATTNLTAGKRFATTDLCHARAERLRLLFPGEKQIDKVLSYDAMCAYCVHFKARMKKHCPDVYEAVKNTRFCIPIVHVENHADICMYLYAYVYKPNVGRFPAETAEMVWPELNQIGGATRQMTPGRREDTIIFHLSYWNFCKQNNCASTLYSDLVAAIQLYQEHRDYFLTVCEALGEDKVNKYNQMDRSPILDPNNKKIFHSVYAHDQSKAPTRDQLLESFKRSTDTKQCGITLQNIGEIAIFLMEGITIQELHKESERSEKLKLENEREKLDKRISAWREAQATIMPTCGEYIVQSQIVNAENEKLFLPSDFAAKDRERLGLEPLAEEEARLREAYGTDLISHLQYISQILSALRHRNVIHNRALEKLGRLDATFFPELQLKDCYRKSSEDKRRVGDSRNQDGRLWISSARHGNTRESTAEQASADLEEHEDLPVVGTQSSRRAVKLKAPAVSPRKMKSSKGKEKALEELAEQEDEEPLEDDEDDGLLWRVRPRADFTDEQMDDFIEENKKVQFFCDEAMMERWQEQVEIKHAEFHRVIRAFGKYMEVWTDLGKTWEERGKPGHVAYARKQAAMYSMLKSECQKLFEMAATIDIGLRVIPEGKKLSDQVLIFRQEERKRFSMITSAQPPFIDLTDTIPPIEDDSAYENDECIEEETVEDVESDVGSDDEDDLETDDEQVIGEGGAREKRRRESVEDNSRLHRRKNVGDGDKTSETKTGRSLGHSGEGSGRQQRRGGDGIETGTTDRDGLLESEGDVFQDNSGRGGHSRDENLDFVGVESVDLDTEMSENKGDMVMSTVVQQCMFHVFRGCFADVSTSHTTCSVYALAFNDGSGRANYKIGMTGRALETRLREWRWKHESKSFTLVYSVQINGRATAYAILSKMSSNVLMTTVPVFAGVDFNIWADILVAWLQATGLSSVLRSDRPDDAEVSTASPLSAEDAAAQSEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLGMTTAKEIWDFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAYGIPTDGTSTTSVTKVANFLIVMFIISKLPPRYEYLINQYTQYTLEEVDNANLDVLQNEIVNIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQQQQQQRPSGSSSGANGASSSNGNNKGKGKGKGKGKAQFRRGGRAGKFEQAKRQGQAHLVHDDMSPLMHTVTIVDTPAAVDTRTKRAINLARNIGARPSGETVATLEDVVMSHPDPSSFTPLTPAPRSKRTLTERIYWSNLQSSSDGWGNAGNWNGWNGEYPEIQTGSDADMACAQGEDASWNEDTLVNTSELGSVFGTTTTELGAKVSQDIRTPVPLIDRIAADPAAEMMECAIHLGERFQNPEDSLHIYGEPLRVALNTVAPTGTSGTLSLVQRLAAVRSERPSGSQPAPPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGGMELPSRAPTPSSMPELRSMSPSLSETSDLEYMSTPPLIGGMSLPTSPVEATWSDGIPSPRPSTPVMVTVNAANNYGWSLDSEPSGLDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7P2</accession>
    <name>A0A8H5C7P2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7P2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5336666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="388" mass="44078" checksum="8B4C3E61EDE5F46F" modified="2022-01-19" version="1">MSENPASATAAAGGTEAPHNAAPFDDDAQSSALPNTTTKEQGVKPEKFTGDWNQTKDWMAEFNNYLRLNDQVYPTEDEKISFFLTLFSGEEVKRWAHNMMVKVFEEEDDFSDSDEEYTSTDEDSSASKPKTKGKSWTLHEVKREFLRDFKPSARETQAQTKIEHIRMEGTLADIDKYNSQFKRYADDTGYNDKALMKYYRKGLPRGLVDRISYLSTQPKNLTALQKAAVKQHMIWLERQEEKTSWSKPRREEGQPGRRSQGTGSGRTRSMEVNAFQDNVPGASPITKYPLKLTPQERDKMRKEGRCFRCRGQGHMGNDCPTFPSTPPTIPNNTTWRPSIKKTAAVTETPDPRVNTTIDNVSELTTRIGALLGEEKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9R3</accession>
    <name>A0A8H5C9R3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000204">
        <property type="protein sequence ID" value="KAF5337860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9R3"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="11769" checksum="74DB7931317B3B68" modified="2022-01-19" version="1">MSIAREVGLTQVSQSANLVPMTKLVPRGVDGTADAYLTLILRQYYLDDFLSGFDAHSCKGSGASTSSASSSSSGSKSTGRGDKREKEGTRKPRVEFMSPSEAWSTQTDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAY8</accession>
    <name>A0A8H5CAY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000199">
        <property type="protein sequence ID" value="KAF5338163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAY8"/>
    <dbReference type="OrthoDB" id="3261066at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18186" checksum="2738F7533B68CACA" modified="2022-01-19" version="1">MQPHILYASFRRRNEIYSWDLCSTAAIPVQIFDPELPAVAPVAGTEQGPTETPPVPNDEEAKSQAKFLTRQKRRFDVDISGKWLGIGNQEGVISIFDTSASDGSYAYDESSKSRLMLTSHTPSALKWVAAKDSIGSVSFNPLSLLSRHGTACTLLNAVATTLLTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB21</accession>
    <name>A0A8H5CB21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB21"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="487"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="733"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="769"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5338450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="964" mass="105118" checksum="A4FAAB0FE71C0A8E" modified="2022-01-19" version="1">MNTSLEKSISPTDNISSPSDDRKQSPPAFLDLADSAARLGSNMSDLSARVELKRIEHERQRAIQRKVFEDQMRALEQQQAQEMLSIPYDPSLPNGNNGIQHLAVSAPTTPPRLNVALQGDLQSGSKASPSILTEMDPFFRSDKRKSVTYAPSVNLSPDLSSGGSFARSAGAKSMPASRRTSASEHDEELAGHLQNLALEGQRSQRGSPVPPSVVTASILNRGSRFGDDEGARYASTYNAGMMLDEQLDQEMHNAMKHLPTSDDDKYHNQTQSHRSGPRITAAQTVSPLRMALNIQTNESSIGGNVSASSPLIHQSAQGLSVGTPSSRRGSPPNLLNELNGTTRSVPGTPLGMPSNPLLKTPGTPLGESPNLNGRLSNQGLPGSDTIVNASDLQASLSRLPANRYENASLNFNGGIQAGLDDSLRSYGVDSGYGLNGDAQYGSYGSPGAPGNTSGSTALYHHNGSRYGLGIPGRANPLDNKMNGLHGPKHKRGDMDREFNRFAGTRLEDLQGEIPALCKDQHGCRYLQKKLEEGVPEHRDMIFRETFGHFADLMTDPFGNYLCQKLLEYSTDDQRNVICESVAQDLVNISLNMHGTRAVQKMIDFLSTRRQTDLRYNAQIHSIIVALSLHVVVLIKDLNGNHVIQKCLNKLTHEDNQFIYNAVAANCIEVATHRHGCCVLQRCIDHASDHQRIQLVNEITFNALTLVQDPYGNYVVQYILDLNDNRFSDAVIRQFTGNVCALSVQKFSSNVIEKCIRVAEHATRKILIEELLNRTRLEKLLRDSYGNYCVQTALDYAEPTQRTLLVEGIRPVLPLIRNTPYGKRIQNKLQREQLDQFGGYHSQQALVNMALGNQGMGLAQGGRHLTQNLHSGNPLADVYGGQNGLYSLQPTASYGQGPLASQLIQPQSIDGYVLQGNSSHNQGVTPAHGNGFSAASFGGVNHFGGSALHSSLNDPYQRSGFSYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCB0</accession>
    <name>A0A8H5CCB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_015577</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCB0"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="124"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5338853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="54913" checksum="BA6505930D6DFC7D" modified="2022-01-19" version="1">MSFLSTITEGKYPTHAFRKKASFPAQRRINSSCWIIINNHVYDVTVYLGQHPGGAAIILKYAGRDATLAFEPIHPQDTLERNLPATCHLGIIDSSSAETLAEQNKSRVKTKDELRVEEALKRRPPLHRMLSLYDLEDVARKVLPFKALSFYSSGADDEITLAENARAFSRFFFSARVMRPVSRCDPSTTILGYKSSLPIFVSAAALAKLGHPLGELNILRGCAAANIIQMVATYSSISISELASAAAPSQTLFFQLYKPSKQADAKQLIQEVEKLGYKAIFLTVDAVVLGNRERDVRSPWLNDEKEAMKFYVEEEEKEEVNLLGTSTSSILNDDKDMSWDVVPWMRSVTKLPIILKGIQSVEDAVLAAEAGVDGIVLSNHGGRQLEYSLPPLEVLYGIHKRRPDILTKMEVYIDCGVRRGTDVVKALCLGAKAVGLGRPFLFAQSAYGEAGVNKLIEIMHREIITTMRLVGASSVKELTPDLVERVDWESVRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CIU2</accession>
    <name>A0A8H5CIU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CIU2"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="521"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5341603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="797" mass="85671" checksum="1DE5509378BDFD37" modified="2022-01-19" version="1">MRMRIKMKMKLRLDSGPGPGPGSALDGSSEGLNSVARSKSTVASPVGSTILASSADAARTLNRALGLGGDGDSRSPSARSTMKGKSGLRNVMPIPSPSLFGSFPGLLGAMAAGGSQRRKAGASISGGGPGGGGGVGSTGGEDNRKTLFNPAISNSDSTTHAASGISSNTGSGAPSVPLESIIPAMAKPPTQYLSRTYTPLTAKDLHFANFAYVATPYPYSPSSSKRFSFGFTGTGGKGSEVSTQVLTDRYGFVYDVSQYDLLLLLRAKECGCSAPACLTGVKIADREEDNTWPDSDDEQGSNMGSDDEVEGASMRTGGTGRKNKKMKIEVVKEICDCDGEGRRNGDSRQGLATPSAEAEDDTTTNDAASSKTKKSESSSKSRKRRSMPVSGSGSAATVAASVNSSMSSVLRVNAATPRHVCPNTVRKLLGALIEIHDEKQKARRKEWDAFVKQRSKAKAKSQGQGPKASGGAAAILGLDANAYEEVEDELDHDEGLIGFAQLGLSSNKDERREFERLVRKEIPLVYRSKVWLECSGGLEMREPGLFRDLLAEVEKEEREATERGEKVGGVIMEIEKDVGRTMPLNVFFGGDGAGVEKLRRVLRAYSRRNPAVGYCQGMNLVTSTLLLVHADEEEAFWVLAAIVERLLPEDFFSPTLLPSRACPLVLLDYVREYLPKLYTHLINLGVDLPAICFSWFLSLFTDCLPVETLFRVWDVFLVDGLDVLFRVALAILRSNEQELLSCQSIPAVYVALENLPTRMWEADKLLQLETDLRTSILHNDLVNKREAHVATLSQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ60</accession>
    <name>A0A8H5CJ60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_015866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ60"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="122"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="372"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5342722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60414" checksum="D577E60DCFCEDE6B" modified="2022-01-19" version="1">MNPSTLTQILAQISQNLHAAQQSLRAKVEALTGISKSSISPVVMHEHTAESPDCDTDSSSSSLATPNSDTPLSSPPTPDTVVSSASMTLHKLVDKSNTEFLTSLTPHDASSSSREHELYPHRISLTTYPGQSGISPCPMTWGAPTATLRGPIICSRLPASVKHRNAIGAHSGSYSIYRALSIAMGALNPTYKPDYTSTEPPKSVEIPFVPAWADPGKIVSFDPWGHLVPKVFKKEIDEGLDIRPSIAVTKAQLKLSEIDETVRRGQIEIDGKIVVKSRPVRREDGSEDDTVDPGVEVSVSKAAVEPVWFLPGVAERFGISESLLRRALFEDTGGMYPELVTRPDVKVFLPPIGGLTAYIFGPPSYLRDPSKHLTLRVHDECNGSDVFGSDICTCKPYLIYAIEECIRTAQNGGVGLVVYFRKEGRALGEVTKYLVYNLRKRGGDSADRYFKSTEMVAGVKDMRFQALMPDVLHWLGITKIDGMVSMSDMKYDAIVGSGIEIRKRYDLPEHLIPPDSRVEIDAKIASGYFSSGKVVTEGDLKKTVGRAWEEADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJN5</accession>
    <name>A0A8H5CJN5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJN5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034240253" evidence="2">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="30602" checksum="F41B3A53CAA76503" modified="2022-01-19" version="1">MLLKYSILPFFVSLGMSAAAAPMPGKFNDALMVRGQKSNGNDGGAAGQAGQAGQAGQAGGDSGALTIATAGDASATDAAGGANATATDLGAGGAASATDVVGGANATATDLGAGGAASATDIGAGAGDANATITDVTATATDAAGAGVVTVTVTVTEAAGAAQATAATGNANGGGRKKGKGKGNGNAAAGAAGAGAGADQAGAGAADAGTAGQAGAGAGAGAAGQKGAGAGAAGAGAADQAGAGAAGTGAADQAGADAAGAGAADQAGAGAAGASAAGQKGAGAGAAGAGAGAAGAGAGAAGAGAGAGAGQAGADQQAGAGAAGGDLGNIIDNIASGKGTGDLGKILGLRNLNARRALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK63</accession>
    <name>A0A8H5CK63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_013677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK63"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034431340" description="Cytochrome b5 heme-binding domain-containing protein" evidence="7">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5342978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18751" checksum="8691B3B4A5D40A44" modified="2022-01-19" version="1">MSFSLDTPINTALFLFILYSVQRIVFPSASATPKSTPREFKSGYSWMPKAHPPTVLFKTYTPKTLEPFNGKDNERILLAINGQVFDVTAGRNFYGPNGMYGNFAGRDASRGMAKQSFDLEMLTPLDQPLDKLQDLTQDEIDNMKGWIEHFTNKYIVCGRLVENNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL81</accession>
    <name>A0A8H5CL81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_013665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL81"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5342976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="486" mass="53977" checksum="87166C022C7CF658" modified="2022-01-19" version="1">MALMAASTWNRRLIRERGLAMGREHVGKGVNVALGPMMNMGCIAQEGRNWEGFGADPFLAGEAAYETVLGMQQAGITACAKHFMFNEQEHKRTTTSSFVDSRTTHEIYGHPFLRSVMAGVGSSMCSYNAINSTYACKNSPTINALLKSEYGFRGYMMSDWQATLSTFGSVAGGLDMTMPGDITFDSEDSYFGVNLTEYVRNGTIPEERVDDMASGWFRWFRNGVEVLDVERWFLACWLLASRFPFPVHVFGFFFLLEAEVELGMGYGFLASSTLANSRVFMGSGLLDDVGWAVFESTRILAAWYLAHQDSPSYPSTNFNAFNIPDEATNERVNVQADHYKIVREIGRAGIVLLKNEKPKQKFPHTNTDLDRPALPLTGRERAVLVAGLDAAPQRGGPNMFSDQGGNEGIWRWGGEPSTLFDWQFDDFTPSALTSLRSQAARKDAALVFINCDSGEQYLSPDRNEGDRKNLTAWDNGHTLVQTIASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLW0</accession>
    <name>A0A8H5CLW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLW0"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5344115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="402" mass="42960" checksum="63E311A189DC4AB2" modified="2022-01-19" version="1">MSQSFPLDHVPHSAIRMLQFLVSPRIGSLSDKYGRKRILLITMIGNILSALVWVTSTSFASYMLSRVIGGLSEGNVQLAIAILSDVSTPANRSRALAHVGIAFAICFCIGPPIGAYFASRPLPSINTFGMELNVYAMPALLTLVLLTLETLFLILALPETRGKDAQAANAEKNASDEKKPANGTVKTSRAPTVEKRISLLSNLGLVHFLFLGVFSGVEFTLTFLTFDLFDWNNSQNGKLIGSIGIISALMQGGYVRRVTSKIGEGVMARRGVSSCVMGLVLLAILPNYVSSNLTLALRLLQLAAVCMAFTSATVVNSLTAFASLQCDEGGFDPVTGKPIKEHPQLAKGKALGKFRSSGQLGRAIGPLIACASYWTFGPTYTYAVAAGAMLLVSVYMRRAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM56</accession>
    <name>A0A8H5CM56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5344028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM56"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="275" mass="30562" checksum="3AA0E83923BFDB4A" modified="2022-01-19" version="1">MPLPRINSRTPLRDSSFGHKPNSMSISAWPPVVVPGRKSRSRLSIIFLLSLVLLSSYILIIQRSTITASFTLVPNSSESVSTPDIVLALEALKHSHAKLSSHQKAFARPQIELTPEQELAAVSSFLASLPQNIIPPFVDPSHPIDPQLVLDFDTRGPRAMDEMKFVTEQTWSHNPVFLYSKLYSPISREIKGMLHSMHLSPSPTMIDVDIRDDAEVLKPLIERLTSSSDLPILLIGGKPVGSITEIREMHESGELKQRILDAGAVVTQPKRKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMK7</accession>
    <name>A0A8H5CMK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000123">
        <property type="protein sequence ID" value="KAF5344539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMK7"/>
    <dbReference type="OrthoDB" id="3027307at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="249" mass="26805" checksum="1B1D9577EBCEAFA9" modified="2022-01-19" version="1">MPPRKTSSCPTPSPAPLPAPAPPADGNWDLYTGPLYLAQRPLRLTHLCPYISTFVSYLFHEETHKWLDVMVSSSLQPHSVRDMVGRVFGSRSGDLESYYADEAGGASRGGGEKLGSGSGEAEPHAPENEKTKENKPGLIAVWARDTLDLESKTLLPPLHLRPPLTLATPLAPRLALTLTTTTTTTAPSSFPASASEEKGLHPTIYLANTPTPTTYYPNASTNAPPPIPPLPPHNPPPRRLPPQSTFKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN46</accession>
    <name>A0A8H5CN46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Meiotically up-regulated gene 152 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN46"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="110847" checksum="A598F2013465AE0D" modified="2022-01-19" version="1">MSQTGDASPTKEHTKFHLPSSLTFSFKAPFPASSAASSPSAVPLKQRRVSLALPNSPRQVEAWSFRDDTGLASVLPSNSSEVCLVPEKSGKLRRIAPDEDDEDLGGLQEKKQRKKWTPEETQMLVDGCNKHGVGNWKVILSDPAFKFDGRSPVDLKDRFRTYFPDAYKQHYPNARTHLSSKVRSTLPDGTSLFEKTRSKKRRPFTEEEDRALKAGYEKHGTVWATIVKDPIFQEQKRRSTDLRDRFRNAFPGLYQAAGYKPRNTKKKLGSVDLPGPSTSAGKMPIRAATDDQLSMTTQGTVRRRRRNTSSGLLRGGTKSVPQSAAASEDEDSSEDEVGSSKPCTPPFSSVWTKPPPSSASPPELAPSRSTSTMDDDAEMSLVDASMSLQDFIGNTSSELDAHSQTWSSGLDTPVHSHAPWAASPTSSHVSTDYLINSPFQGRNEGIVGGMGMIGKSAWGTQDWFSANPRLDNSGTSTSSYLDGLSPSSPFSFNNLNHGVFDRYDLVPGSNFSHSEVGTADSWSTFSDEMFPPTHSNYAGDLIAGARTHQPQTDYWGGIGRGLASLGEENGLGLVGMGPPVLQQSTGIHPMDLHGPALPAAEEIELTGMRLDDRQQSEQRHMDDSSVDIGIVDLSSPRESEHHRSMQRGNHHNHRDFQNREYSHQRSQSVMSDTRFSLDDLVDFSNEAHSTPPGTPYSQPRPLRKIVRSGSDASVLGHHGSSSHGRSISVPPSERVAPAGQPGSPSPSGPSTPPGRHMRSPSVHQDMLGQMRPLDLSTALFGGQQLPHMRQEQQNVSSTTPATVLSPTLTHPGQPTFSSLFLASMAGQNSNGNDAVTSGASTTINPNQTSIGTSQPTSEFYEIPFLDLHYYGGSGANGSAMFPAPTPLDEAQNSRQALDLAQSAVSSSYKSSGIVHSAITSGQVPLTPSLSRREANVHPAAELSAGVIGAMGDVLSSLEKTQSRTLVSGMVTPSVAVSALSLSIRGVGASSSHVNHHRGQSAASVNPQDLMLRSDNHKRKRASWDGAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNJ7</accession>
    <name>A0A8H5CNJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNJ7"/>
    <dbReference type="OrthoDB" id="3017535at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="919"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="984" mass="107733" checksum="6E4ADFF395D72127" modified="2022-01-19" version="1">MLKGNGIECWISGSFISSLNPTEELPHEDVTTRVEDGVTIVETTLNLARGLDWYELDWRKAEDADPQSLWCVVKWTSGTAKQNDVVLSETWMSHSDMKKQERSAKDSLRKERVRWPRLRVLRTTKKMGTLCLEVQRIKGDKDSGSENTKGEDIPPEDKKPFCVFIFKFINLAGSLGAGVGVINTVGKGKKRSRVSFKEGSDDEHLQPSISPKRKRPRLRIKPPRLPPPPPLNHDSDEEHDTEAETDESHHWHDDTDGERPVPMTINSSLQIETQESQIIEPSATASAALAVAASHAHSQSDATASCVTPVNFVHVPPVNTNSPPFLLPLVPARAPGSARSSCTNDGALMPISADLGARIHELREAEQELVKEKEQQMELENELAEITKILEVQLRTLPSDGSISVIHPFGASSGGSGNSNEVRSPYISFVIKQSSQNPNLTSEIPHQNVKTRMEEGVTIVETTLNLARGLSWYELIWRKAEDADPQSLWCVVKWTSATARQNEVVWSLQTTKKMGSVRLELQRIKGDVTIKNSLNDITVVEDVLLQDEKPTCVFIFEFVKVATEIGSSGAGLQVINTVGKGKKQSRVSFEEGSDDEHLQPASISPKRKLKTKPPRPPPPPSDHNSDEEDEHETETETSDESHHWHDGNGDPGSDDASAMDMKEFAPSPRLSRSSSPLLETQTMYSISPPKPSSKSSIPNRGKDFVWKQPCIPTVTNPNSVRPAAQPGPSSSSPSLSKPQVQPSSSLKSKLASRKRDLKMYRALLSSSASSSSSSSSSPGNPLARRGSKNSKSHALPETSHSPTTGSSLDGPVRLAAARSGLRTPPKPQEGSATDDSTTTVPLPLCSDAMADARPVPEAINSSLQIETQEFQIIEPSATGSAALAVAASPFLWPLVPVPVHAYGSARTSCTIDGVLMPISADLGARIHELEEANHELVKEKEQQMELENELAEITKARTQSLNTQIDSLRAENERKRKWLQLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPT3</accession>
    <name>A0A8H5CPT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_013051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPT3"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5345680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="786" mass="87575" checksum="08BF76A781A89C64" modified="2022-01-19" version="1">MATIDVLENDSHPQANPGHLERGNSSFDEKDSKFLKEDEVEVEVAPDDAGGIYEDVRIIDMGSDGKERPIETDIDVATRLISLEDDPTLPCWTFRMWFLGLGLSCFGAVLGQIFYFRPQTIFVSQLFLQIIAYIFGVGLETLLPGPGNPFPNMQMKNNAFWRFFNPGPFNLKEHVAITILSTTAAESALAISVFAADELYYNIQPNIAVGIFTLIGSQLIGYGLGGMMRAFLVYPTYIVYPSLLPTVQLFDALHRGKKIFMQKKRVKFFWGVFVAIFIWEWFPEYIAPLLTGFSIFCLAAQNSPWVSRIFGLMARTGGAAGNEGLGMFALSLDWNYVGSGGGSLGALFTPFSTQISLYIGVLFCIISSCVAYARNTWNAKTFPFLSQALFTDTGDDYDQLAILDDNFRFDPSKLEAQGLPWFASAQVLFKISSNLSIGATIMHVILWYGKDIKQAIAQYRRGETQDPHYAKMKVYKEVPMWWYAVVFLASFAMAMATIYTGHAALPWWGLILSIFFATIFLPFTALVYAITGFNPDIQSLIQILGAALMPGSPQTNMYFTLYGYNTVLQARGLIRDLKMGQYTKLPPRVTFVVQSVGAVVGGLLNYVIMKVIISAHREILLDVQGSNVWSGQQVQTFNSDAVTWGALGNIIYAPSGRYGIIPLSILIGLAVPIPFWILHRLYPHMHFNGVITPMLTYGLGYLSVGINSSVFTTFCLAVFSQYYLRKYRPKWFRKYNFLMSAALDGGTQVMVFVYTFAVGGGSGTVVNFPQWALNPVGNPDYCKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR73</accession>
    <name>A0A8H5CR73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_009917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR73"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5346128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="39376" checksum="F3A7CDAAC82398E7" modified="2022-01-19" version="1">MCIQYEDLAYSAALSFATVGANNGHNGTSGVPFLNKPGVIEDFAYRSIHTGVAIGKTLTSSFYGSPHTTSFYLGCSTGGRQGLKSVQDFPEDFDGVVAGALAADFNHLLSWSGHFYAITGNSSASRFVSPEKWVTLIHPDVIAQCDGIDGVEDGIIEDPNLYFCVMKRKRREDCITEEQAEMIREVYKPFFIQRKLAFPRPQPGGENIPIMYTGELFGYTSDWFRYVIYNDSSYDVTTLGEEDWALAEQRNPFNIATWNGNISSFRDRQGKLIAYHGQADGIITSANSERYYEHVSSTMGLDPSQLNEFWRFFRISGMEHCSGGVGAWTDLGRSWRRGWKWRQCYGFGVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRC2</accession>
    <name>A0A8H5CRC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRC2"/>
    <dbReference type="OrthoDB" id="1534087at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="40545" checksum="10A03B803E2B1E10" modified="2022-01-19" version="1">MGVSQPQDTPQKRITHDTIHFAIPAPPKIFTGRDALINEAVEILCRRSQNHLAILGPGGIGKISLALVISNTPEVQAKYQKFHFLPCDILEDQNGLIQGLIQVLGLHMQEGKSQHAILYDYLQINQNPLLFILDNFETPWNYKNARTEVKHFIEKIADFSSITLIVTMKGMEGPGDIAWKILGKSQIPTLSREAAREAFYQISRKIKTEDNSGKFDHLNEQLDCVPLAIRLIAQLAKKINLENLLRRWNELETKIVSESEAQPGKLTNVEFSIELSVGLFDPTAKDLLGALSYLPNGVPHWNQTLSKMLPEVPESEIKVFQLLDCSLVLEKSEALMMLAPVREYILVRYNISDFCHNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRP2</accession>
    <name>A0A8H5CRP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRP2"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034168721" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="200" mass="21463" checksum="CAE4AF049D8060CD" modified="2022-01-19" version="1">MKFITAATVISALFVGALAQNPFAHIVLPTEGASLKAGTNVSVDVARALFVSLVSEFWRSVAEMFFLLLRSSFFVCLLSTVRFPSTAHCHTVVLVPTHPSQDPQGNVIVESEIGISLGLASCPNDPSDCLDPSESMGTFLYGGDFYPVFGDGPEPNVNITVEIPANTPKGEARLNLGHFFLLGQEFKPQMETSSVKVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTL9</accession>
    <name>A0A8H5CTL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTL9"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="266" mass="29348" checksum="C79F71320815F663" modified="2022-01-19" version="1">MSLCDDCIKGVRHEGTPSGELKRINGVDCYVATPEGDYPKDKVLLFLPDAFGVAQNNKLLVDDFARNGYKTVMLDYFEGDAVPEAAYETLIAGMRGEKLASLSQSFAPTFNIGEWIAKHPQEIVRPLIDKVIAALKEEGVTQFATTGYCFGGRYCFDLAFDNVSKVTIVSHPSLLKTPDDLEKYFASSKAPLLINSCPIDPLFPIEAQQLADKIFDDGKFAPGYKREYFDGCVHGFASRGDMSDPKIKAGKEGAFKAAVEWLKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTM1</accession>
    <name>A0A8H5CTM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTM1"/>
    <dbReference type="OrthoDB" id="2687121at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79463" checksum="1F82F1970A1C5693" modified="2022-01-19" version="1">MLRLNDVFMQGSADVSSSFWQFMNQDVILTVRSSGRQHKRTAEADPDDTSNLSLTSSIVSVVASNITKAVKGASKAVKGTVKKVKKAEKHSCQMAPSPTSSECEPIEVSDDTSSNVEPEHSREENDEDELKQLWAHWTSPIYSFFHEKPTVAYQDNCKYHHFKSKASKCKGKGGVHHYLDGGDHVSTSNLKKHAVSCFGKDAVDAAIKSVAEAALTQNSIFSMFTGLGNHVVSISHRMHTNLEQQQLAVHLQHQGKPLVFLLDIVEVPESHTSLTLAHEFDQMLQHLGLEQKILGVCRDNATSNDTQTTALDASESNLFTVKGHVLLNGISGSFDKGDTVLLNDDIEDDEDDLPPLLDDDILSDNEDEDIDEVSGLDDTAKVTFEKETSEVWVALEKICNKDLPYHKHELTTSEWNILKDLHYVLQIFKDTTVHFSSKQQSSISAVISTMDHIDNLLTAQMVTAPTSGQDADSTQPPLHESVKAALRLAKQLMNQYYSMTDESAIYQIAMGLKLEYFHCHNWKQKRSHVKPTMSILNKLKLNKLCKVNSSTASATATPSASSSFTPSFNDFTNISVASSATVTTHDKLSDYLAMPLENVKDPLLWWLVHSLIPLPGKLEQEDIVDVLLDVEEKKAKKQASSSLQYTVVLQTCGCWVRDFDASTCKSENFATLISSAFPFQEHNLAYLSNAVRFAPQQVARHSQHVRTIAIHVILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUV9</accession>
    <name>A0A8H5CUV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUV9"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="26309" checksum="F627B64D3A60DC7C" modified="2022-01-19" version="1">MQRLIELAHQACISCSHILGDPHFLDKSPLALNLSVFLVGLELWKANKQALITAAMAAFALLRLLTNIVAGARGAVAPNFQQFIGRDKWLLITLWVTAAVVDISVTACMTYTLSKRRQNAIQRTTELLDKLILWTIVLLQLLQQLRLNQRGVLREQRKDGVISMSIPNSNSAPRMTIPGLSGTDTVNPDSDFYLSRSGSMQFSSNRTQPVIAIEMNTVTEMDHDADEAKSDGKAYVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1P9</accession>
    <name>A0A8H5D1P9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_009413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1P9"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5352022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="44609" checksum="95F51A87316545B1" modified="2022-01-19" version="1">MPVPVRAPVAPGGLKSYYQAKIEASELTINQKTQNLRRLEAQRNALNARVRLLREELQLLHEPGSYVGEVVKVMSKSKVLVKVQPEGKYIVDIDSEIPISSLTPNLRIALRSDSYTIHKILPNKIDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGESGSGGGDSEVQRTMLELLNQLDGFESTKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPGPEARVSILRIHSRKMSLQRGINLRLLAEKMGQCSGAEVRGICTEAGMYALRERRQHVTQEDFEFAVAKVLKKNQEGNTSVNKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D412</accession>
    <name>A0A8H5D412_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D412"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17833" checksum="DFD57FF4E6BB5E54" modified="2022-01-19" version="1">MPTLLAILLLTRHCPKLQHLFLYLDTRLSKIPSPSLSATHEPADLDLCVGVSELEMEDATDITKLLAQLCSSKCRLDFTREYDHETAVYDEFGVGLESIWDMVAEMPPLFSEAYKAHGGANKQNEDLQREPEVISHAMDIELQNFRARQERAAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4H2</accession>
    <name>A0A8H5D4H2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tricarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4H2"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="189"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5352929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29941" checksum="5CDF236AD8367088" modified="2022-01-19" version="1">MSIAGGTAGAVEAFTTYPAEFVKTRSQFGGKKTPPLTIVRETLAKHGVTGLYSGCGALVIGNAAKAGVRFLSYDWFKSKLVDREGKLSAPRSLLAGLGAGMVEAIFAVTPSETIKTKLIDDSHRPNPQYRGLVHGTVSIVRQEGISGIYRGLFPVMMRQGANSAVRFTTYNTLKQLVQGAAGARPGQQLPSTITFGIGAVAGLVTVYTTMPLDVIKTRMQSLEARQNYKNSFHCAYRIFTEEGILRFWTGTTPRLTRLVLSGGIVFTVYEQIIKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D590</accession>
    <name>A0A8H5D590_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D590"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11354" checksum="EC7A6371ADA9B518" modified="2022-01-19" version="1">MSTSNLFRPIKFGDITLKHRVALAPLTRLRVDENHVPLPIVKEMYAQRASAPGTLLITEATLIDARAGGNAHTPGIWSDEQIAAWKKVTSAVHAKGSFIYFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6B1</accession>
    <name>A0A8H5D6B1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6B1"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="224" mass="25140" checksum="3B6CE650AA7CE13C" modified="2022-01-19" version="1">MEGALADIDKYNSEFELYAKDTGYNNEALMKYYRKGLLKGLADRISYLPSQPKNLETLQRAAVKQHMTWVERQTEKALWSKQRGEGERQTKGSQKTGGSRMRSMEVNAFQNNNPGASPKVKYLPKLTNEERGRMKKEGRCFGCWGLGHTTFNCPTFPRSSMSNSDNTTGKPSIRAATTEPSPSGTNTIMKEIAEEFTAKVRALSGEEREKAAGYLKDLVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7V8</accession>
    <name>A0A8H5D7V8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7V8"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5354368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="260" mass="27677" checksum="8C5BD50661D87F11" modified="2022-01-19" version="1">MSYGGYGGPPPPAHSHPGYGAPGGYGGAPPPPAGGYGNPPPPGGGYGAHASGGYGYGQQPPPGAAGGFATGRPMGGPPPGADPQLWTWFSTVDTDGSGHITAQELERALMNGDWTPFDLDTVKMLMSIFDTDRSGTIGFNEFAGLWKYIKDWQGVFRHFDRDRSGSIDGGELREALSQFGFQLSPQLLDLVQRKYAPDPPKATATGGRGVPAAEISFDRFVRACVAIKQLSEAFQKLDSDRDGWIQINYDQFMHTVLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7W4</accession>
    <name>A0A8H5D7W4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7W4"/>
    <dbReference type="OrthoDB" id="2847478at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="283" mass="31777" checksum="B3FA7FF85F412541" modified="2022-01-19" version="1">MSNASSFASEPRSYRLLRPGKHSLSPGVVATLEYNWGVSRGGMDFNASHNKLSVRKDIAALLDKDKLCFVPTPQTLQEMVRIHKSDARPPRPYTESFSVRPYEYILATGSFKGPLYVRDPITKKEQCFEHPYDGLPTFTSSAHPFHVAYHSSFCVLIYHKRLEALYDWGAFVLQAVMDLVPDWSIEPAPELLGYESEEDASSDPKPCPLTPPRGAKSTPAYDCADGYMDNQSITAWIAGVQVPGYAEDPVFDSPRCIREYEESPLSPRSYNENHHNSVPISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F6K2</accession>
    <name>A0A8H5F6K2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000384">
        <property type="protein sequence ID" value="KAF5325571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F6K2"/>
    <dbReference type="OrthoDB" id="3232670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5325571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="428" mass="46405" checksum="F6C951085E87D4F5" modified="2022-01-19" version="1">MSAPTTPNQPEDSVSRLRPTRGRRDRSPVSLFALPSYGYDAPKAPKPLAKLDPRHKPQVKAGLGLSSAAPWSKSHSPSSSFDSDMSASSSKGGRPRNGSSGFIHSLGRRKSLVKAPPPPLPTAPSVRSLIDPPETINTPDSASFLVPTEDEVKRHQLQKASRMLGEDIPPSLIYGSVGLGRVVKEDSIHRRSHSSSSSRLHDLPVISPLPPLPVPSPSNSKTSSPINSKFRRPKTAPSSQDSVPFSSSPSSLSHPNPDSLVIASSHSSLSNSSASDILPLEDQKNLPPRFQRSTDPSSSSKDAARSQIQPQQPAKLRRAATLKPLNISTPSNTIHAHSHSDDIKHLTPASNIDTPFASAIEIEQAARPDPEERSETPFVDSLIPKGAYFTAKTWTKGATERRERREGWSGEWNRQDMQDVISKLRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC91</accession>
    <name>A0A8H5FC91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000329">
        <property type="protein sequence ID" value="KAF5331287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC91"/>
    <dbReference type="OrthoDB" id="2884912at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034922286" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="16360" checksum="728DE2845C7CED54" modified="2022-01-19" version="1">MMLSTRLIIPLSFVSLITPGLASPAQRKELSSFSEKDSIPFAVLTVCTAIDFDGNCADIPAEDDLIDCLDLVGGFTGLNKEISSAVVPEGFDCNFFSNFACTLSQTSPLHSKLSLSSGSFSNFLSISDTIAGGVRGTRDFNDRTSSIKCIKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIB5</accession>
    <name>A0A8H5FIB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000204">
        <property type="protein sequence ID" value="KAF5337859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIB5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="99" mass="11036" checksum="8631D622F103C17E" modified="2022-01-19" version="1">MPEAPQFPIWYTGRLELVYEIMTAGFTIQSLLLNNKNKNMTQPSKKVFSNKHQQCRRRQGGGSCLTFVNGLFRAGSESAGAGAELGPRILRLGRCILYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FII3</accession>
    <name>A0A8H5FII3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_014259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FII3"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="84"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5338054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="38758" checksum="5226BC68673A8560" modified="2022-01-19" version="1">MSVSEKGRILSIQSHVSFGYVGGKAATFPLQCLGFDVDVVNSVQFSNHSGYGRFGGTKTSAVELTSIFDTLELNELLEPSRLLTGYVPNAEALTSVAEVATKLKQQRPEIIYMLDPVMGDSGRLYVAPDVIPVYRRLLPLSTIISPNWFEVETLTNVPLKDMPSLRRALTILHTDYKVPNVTISSVPLQPWLIDAVPPYLRPASDNPHLLCISSSSTYKSSNGHLSSVHAQSVPLLPGYFSGVGDLFSAMIVGHFDPSDTSIPTGKTALSHAVSYALTKTHAVLVATHEYSEKLPLEDRLPTDDEQDKIEPMRKIRRMRGRELRLIQSMDILTGKGPGGLRHMEPWTNFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNB2</accession>
    <name>A0A8H5FNB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNB2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="57"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5342718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="53334" checksum="356601B2009D652B" modified="2022-01-19" version="1">MTLQWALYLAPKRFRFDLADKALTQRLSLHLYSLLRYDLPSTNYDFIIIGGSNPRVLVIEAGVDAPLRSSRWSYTTVAQLGLNGHSITVPRGYVFGGSSAINFLGWTLGSQDYYSKPASMTGDSGWGWTSMQGFCKRVRCAFNCPSTFTYLTLTRLVFPRSQPSSPQLTTPDEIPTSNGTGPLQVNFPNFDLEPDQHVFASAKSFQFSSDSNFKRFEYTTDQNNGNALGFGYNQVTAEDGSRTTRATAYLHPAINNTNNIDVVINTRCQTAFTASTEVILSAGTIGAYRSNPPPLRYRPPSGLGSKTIVNAPQVGKNVRDHPLLSLFWSIDSNRTYDSSLQNTALKWFATKGGIFSASPVNVLGFMRLPQTFFIPACPDPASGPNAPNTELIFVDGFVPSDTNPLPTTGHFMSIICAVQHQNLLKHRHIHSSQKLTLKPPYTPLQNAQDNGMSSGSTTNSHASAPPAHSPPPPPPPHSGNQHNGPGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQZ3</accession>
    <name>A0A8H5FQZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQZ3"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26249" checksum="9B422DB9F4611466" modified="2022-01-19" version="1">MSAITRNKQIPSITLKTELIGKITGRKIDANALIDSGAEGIIINSQFAQRNQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRVYSRDDKAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPVLHLKTKTLKPIVIDPRTHHKEYQVRWIEPVGRFKPTAQPKIAGRRRRIPIRSFHRNPEETAIFTEDDYGRRFMTASGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRY0</accession>
    <name>A0A8H5FRY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000101">
        <property type="protein sequence ID" value="KAF5346557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRY0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="99" mass="10938" checksum="C1D4B961F1D5FA28" modified="2022-01-19" version="1">MPICLPFPLQPIATSFTPFTSTSTTVSSQFAIRISSYEEAREDENTDTQRKRCSMKRGTSTKTNNDEERRDAVGQSAGAGSQTGCQRYLGAVWVKREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUL1</accession>
    <name>A0A8H5FUL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUL1"/>
    <dbReference type="OrthoDB" id="3365874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5349318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="23271" checksum="12323CE143937285" modified="2022-01-19" version="1">MTRGRKKDLTIPPSRALTQQRDYRARKAKYVAELEDRYRKVEAENVSLRAEIETLRAGLPFTQSVDSRVLSASSDLLRDLNNVSAAITRFQTLAYSQTSIPPHAAAVPAENPVNGTVQTPASRLRPAFFPSPTPSSSSLLMSCDSEGHSPSDRSWSEENSRPPESLRKILCDSDIPTYSSPGYTSQDKSPSQSPRDSERGDSPDHFMSDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV14</accession>
    <name>A0A8H5FV14_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV14"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="143"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="608"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5350800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="711" mass="75022" checksum="107E2B583BD552B8" modified="2022-01-19" version="1">MFQEVAWCRVPALLGPGMKRTATALSFLSLGLAASAGRSCKCMPGQPCFPTQEEWTAFSSKLSTPETLIVGQRPMGAVCYPNDPLFDVNACQALNSSVNGFNHVFMSAQSDATNWLNLDSIVTEQGMEGCPYFPLAQNATCNQGRVPPYAVNVTSAQDIVEAVNFASEHNLRLVVKNTGHEAIGRPFGVGALEIFTHNLKNLTIHDSFVPKGAPEGTEGVHAMTMGAGVDWRQAYESIDKVNRSVVGGLSPVGTVGAAGGWQLGTGQSVVSPVFGLGVDNNLEFTVVLPNGTLTTVNEYLTPDLWWAIRGGGGPSFGVLVDVTVKSHSGAEYTGAFFVGQATDDDSNLELLTLWMKYHNNISDAGWGGVWPFAEGQLALTFGARGNPPENPNGLSTFQAFFDDAKKLSGVNVSTAEFHVFSSFGEFVETQLVNPSTVIGFDFTTAVPGQVQSVTGSWLMPREVTAEENAESFAKLLTNLTIVGIPFFVGGGAVEDVSKNETSAANPAWRHTITDLTISTGGAAFTDARVIQQAVHDQLQPFRALAPPPYGGQYVNEADALEEEWQLAHWGTQYPRLLAIKKEIDPNDLLIVYHGVNSEDWDQEIICKTTNGTPSSGSSGATCPGAPTESSPSSPSQETESSPSQGSPSPSQSSEGSPSHGHGAHGQGSHGHHSQGSPSPSGTPAPSQSSPAPSSVPSGGSEEEDDDICESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX20</accession>
    <name>A0A8H5FX20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX20"/>
    <dbReference type="OrthoDB" id="3025690at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="536" mass="57463" checksum="BB7992B70EBD6F44" modified="2022-01-19" version="1">MIGKFVYYSLFLFPPRRTMPCPGSGTCLLIDNSAQPLFNALSGNDDWGLFSSDAYLGGSMALSGPTIGRGLGNVTITFQGTSISFTGNTPSSNDSPGSFLVTIDSHKPYQATFPNFSLIQNHTQWYQSPLLSDSTQGHSITISQIATGLDYAIVSAGQATESLDQYQILVDDDDTEQIWYSGKGWETRTDVLELNGGFLDGPPVGNTTHQSNTVGDSFEFQFAGTEVEVYGVFLWTANGEVDIGFNLDNGSQMSSARLTVSNNAPLMDQQPYFRIFQGLNLSPGNHTLFANITSASGTQRLIFDYILYRPSFSRLADKPVFSPASSSSSSSSTTSDSTSPTQSTSESDAQNQQSNSGLQGGEIGGIVTGILVLLLLVGTGVWVLRRARRRRGPGQRIRSIHHGDGIDIGIPPTHTDAMESLAPTPLILPPPSSIQATGYGSEPGPGSGSGSRRNEKSSMGRGRSPTSTDLSSPSRPGPWRNQIQPNLPGHSTSETQVQINELRVRIEELTQSLAPVTSHGSQVESSPPPYAKVDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXF5</accession>
    <name>A0A8H5FXF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXF5"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="87" mass="9915" checksum="39FC50F25DE9175E" modified="2022-01-19" version="1">MFLPLDKIPYTVSPMPSATLSLQASIEMPFRPVQMTTETALGVTKRVVQDKIPLDKIPYIASYMVKHNQPILPPGMQELLYIHTYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYB8</accession>
    <name>A0A8H5FYB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYB8"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38942" checksum="9F40208B7880B621" modified="2022-01-19" version="1">MVAAVDLMPLGLSTRTLTTTFLIALTASGFYYYQYKMPSLSSIRASNAAALGSTPYLPTAVFVGGTAGIGQGIAESFAHHTKGNARIFILGRNRQAAESIIASFPKPSSPEAKYEFIECDASLMKNVQRATKELVTQHGVEKINYLVMSQGFLSTNGFTDAGEGLDKKLAVHYYSKYKFIEGLLPQLLKAKEDGEDAKVISVLSAGKGLSRIDRDDLGLKKTFSVRKASAEGPAYNDLMVEEFAERYPTLTFGHAFPGIVRTSIASSPTLSPWMKIGMKTAMGLLYPLSVSQRECGEYLLHGLLTTMKTPGAYRISNVGADYDSDKKKNGKEWRASEEDRKALWEHTVEVTKVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYN7</accession>
    <name>A0A8H5FYN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYN7"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="174" mass="19542" checksum="EE53A2E50F7EEED3" modified="2022-01-19" version="1">MGYPQISDTRISLSREDFHVDPNNDNIHFNETVFTTLANSNPGVDYYNATSAGQVQKERQDIQNGVNAQLINNVKDFKIRTRESGLYIAVMGNVTAGVATKAPKNYVQILFREERLPIAEGWKKNDILITTDVLKPIEREIERFSEWQPSGVQPNPWIRLGPSGAIDPLTANSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYQ5</accession>
    <name>A0A8H5FYQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYQ5"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034670061" description="Phytase-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="87"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="54586" checksum="4FB8DA61E037FA4F" modified="2022-01-19" version="1">MVWLSPSAVLLSLTRLSFSIPFKLRQDSSVTTAILDDVTYTNKGLVGFGFIPSDFRESTGDTLGGIGSAIAFKQGTYQVLSNGSVTGTMVVHPDRGFNVDGTVDYQARQFEIDILLNPYYGSDNLDFEDAQKTVQLTYKRTILQFDRNDTKTTGLDALAVRPAQNGFPSDPLADPEMPIASEDEPHLTIDAEGLVANSDGSYWVSDEYGPYIYRFDANGQLIQTIQPPAAILPMDKDGDINFTSDDDPTTGRAGNQGFEGLTLDPINNVLYAMLQSATIQDGGDDKSTSRYTRLVAYDVSDPTVTRPSLVGEWVVPLPLSSKGNTEACSEIHFVSPGIFLALSRDGDGRGGDDNNSKYKNADLFSIAQATDIHGTDFDDPSNPIAKKGKLNKNITPAEYVEFVSFVDDDQLARFGLHNDDPSDETLIDAKWESLALAPVGDPDFPDDYFLFTFADNDFMTTDGISVGQPYDAGLDVDNQVLVFRVTLPSVDPASVEKALGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYR5</accession>
    <name>A0A8H5FYR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYR5"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF72">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44955" checksum="C8B46B90EE1DC98F" modified="2022-01-19" version="1">MVSQPAYLPFSLPSSTSPDDFSGSLLFYISFILLVSSFHLFAPFISANGDNNKTERKLSWIITSVASLVMTVQSIPFLYDYFMSGGSVKSVRAAPTLAVAANRFFQAYLLADLTTGSFHYRSQINLLTGWIHHIVYIGIVEYAIRQGWASLFSLCACMEFPTFILGLSILIPRTRSNVFFAVSFFLTRILLHAVLAICLYMPWNRPLPQFSEAAIGSMGPAIILTCVFPLHASWFYGCIKGFIRRAKQAKAAKAEGATAVPEKVTEVSSVPVPVPVSIPVPAKLVLLPLLPPVPVPLPILTLASHLLRRPYTHYSHYYTRYTHYRTRFRAFRAEFKEGVKRNTTNVRESWKEGTKKAKDYGKKAREGVREGVRGRSNSIGREMFYEAVGLGRRSASSSPTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G013</accession>
    <name>A0A8H5G013_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G013"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="305" mass="33189" checksum="E7E23AAFDE1D6997" modified="2022-01-19" version="1">MSSQLAFVQIDVFTNTRYVGNPLAIVSVPSTSPSLTQHQKQAIAREFNLSETVFLHDPIQGADSNDPLIFPIDIFTTTEELPFAGHPTVGTGWYLLGRYTDKETIMLRTKAGDIPVIRDSNGVRLQVPIDFKVHDPYTHSFVKASSVQPNLTAADYVNGIDGPEVVASIVKGMTFMLLELASEDALARVMLYAERVKIPNEHLGEWKGFSSLYLFVVMEDGVTVRTRLLDGGLEDPATGSAASTLCGYLSKKKGPGEWKFQVVQGVEMGRKSEIGVYVSVGDDGEVQKVELAGSAVGVMNGFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0D8</accession>
    <name>A0A8H5G0D8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="2084"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2022"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2026"/>
            <end position="2036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5355288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2303" mass="251233" checksum="22A8215DEB9F3D87" modified="2022-01-19" version="1">MSEPVTIEPFDESELSGENGSMYIFQWLSSTEKRIAEIPVDQLKSQQSELEATLVKIILAPEPYPAPGRALRNVVSRCLTLLYTRAESRSLFDTLQAFMKVTSDFKATDKEVYKIAAFSCVGDLMGVFGAQYMSFVAEIVTVTLRTGRSSNQPLLRYQALLALQKSLTTAKRAVTDSSYKDIVKQMKSALNDKCLPIQRVAASVLTALFTEPDAHIVEKNEVESILLLCIKSLDGADQVTRQSLAQLVGHILSTTQIERVVPVQETAPKNKKGDADPADDDVSSPAAATEVTKPMLTLNEMLNLLSSQFNKPNTSRKTRIGIFDFYVALLNRLGSSFVESNYSLIITHFMTEIVSNPRNNTTRYETLSIRRLMGVILRDLIGVRMLSEQGQIGAIRELANLYLKRWPVMMPGQVAPTSAVLVVVLREVAGLLQQLGNAPPPVQDALADPLMTLLAHPSHSTRVNASWALRCFCYSTPLRLPKTIITVIEMLQRDLTSMLSPASPSDVNSRALGHAYGLAALVSIIREWPLYVSYDVGAKVLDMAIQLLKRAGEHDVKIAGVEVEVSWMLIASLMSLGPNFVRPHLPQLLVLWRNALPKPTSKDTANNAGRTVAEWMFLLHVRESALGAIICFLQHNATLITLDVGRRIASVLSNTLSFANNFITVNVEEPPEMQMSGSKGLSLKAREALLRRRVYQCFSILGFSSLAESTQATLLQSVVSLFASPDGYAGSSVQAAIASSSGSFTSVWHSVDGYAYGVTFTEIVSDTAPASENGDPVARHDPLNRDTVEVAIDELLRKPILGGCEHDPLSLCQARVSTTEYSLVEPPPPYTSVVDSAIELFSLLLPLQDLGSTAKTINQLLESVRSPKLEKNVGRKAAVSVNAAIALVLSLRNATTNHFQKARETFGSSQVTGLLSPFLKDSLVDGDHVLRSTSSESIGRLASLAGTNFLTAQMKTLVDQVVNNRDPYARSGCALAFGAIYDHVGGLAAGPLLKTTVNVLMSLSNDPHPVVHFWALSALARVINAASLAYAPFVSSTLGMLLKVYSMNSHELGGGSLSNANLSGDHPAYPVVCQIIDAVTTVLGPDMQESIRTRALVLNLTHNFFLEDDDSIRVEAIKCFQHFLMFAAEHVNIPDLVNNFRGHLSSPRRPLKVASINALYQLVQKDALAMSKLGGDRLVEDLFGMLDDDSSVEGVRNVISSWLQQTVIHNPSAWIDLCQRIMSRTTASQQVADASNTRDDEGESLNLSSQDGSRGRLTSRWRTQLFALQCLHQICTIVAKSGRREHLDVYFAKKREIPTRGLLVSRVPDLIRMAFTASTAYVTEIRLEGLIVLRDVIQIFAQSPDPAFEDALLLEQHQAPITAALTPAFSADSTPEILASAVHACAVFVGCGVVKDISRMGRILKLLTSALEQSKDSGMVSLGEAGEVSPNASAMLRISILSAWAQLEVASYQQSYLLDVVKPYRATLASMWIAALRDYASIRIDSEFLHDTSSAAVDSSYSNLGKEVLLPYYTSSWTIILQAVAAAMQAKDPFVLAAMDGRDQVNGAVGPAKGPRDEPAAFFFIVFGLVYEALAAASTDSMTNSSTRQASVIAALRTLKSLVRPEYAGKAIMEPAIFDEFISVCYRMAMTESAVVEIHLIEVLTIFAATQDQDASASSLTGTTARSHCLRICAHILRHSMPTGRGPTIQGDISERIKMILAAFQAFTAIAASSNNNLREDVRAVAILLYSEILKDDVSEVDLAGPTFPVLKTLLDLPTASGPDSAERYQKLIHGLLSSCLLHIDEMRGRQGAAITKKVKNNLLAAVLILTVIPTTVKVSDAVIDHCCFLISQKLLETSEVSLTAAHCAKTLIAASASGNVLLRHCVKQLLPALIEYIAKMAPSVSDNSISESHASAIGEIWKAFSAFFTSLGENGRARLLGVLLPTISLLLANSQNTTSALLSQTIKHLLSYATSSPNSFKEAAAKLDPATRELLEQSVRKAVGGAAAAPAQATAKPQISLPRQFYRDLVVFNQLQVKAKSTPKSRVDDESHPQDSARPSNMARGPKKHLKRLAAPSSWMLDKLGGTYAPRPSPGPHRLRESLPLTVFLRNRLKYALTGREVTAIVKQRLIKIDNKVRTDPTYPTGFQDVVSIEKSGEYFRLLYDVKGRFTIHRITAEEATYKLLKVKRVAVGARGVPHIVTHDGRTIRYPDPLIKVNDTVKFDLEQNKITDFVKFDTGNIVMITGGRNMGRAGVIVHRERHLGDIDIVHVKDSLDRTFATRVTNIFVIGEGIKPWISLPKGKGTKLTISEERDVKRKRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3G2</accession>
    <name>A0A8H5G3G2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3G2"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034060015" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40082" checksum="97492E6C40440793" modified="2022-01-19" version="1">MLFLKLSLLFGLLSLPHVTHSQALDEAHIQIMFKGHYTVAIEHLVPEKVLHETPIVMIHGHGMTGTNFLNTPDGRLGWADYFLSEGFELFIIDQPARARSTYQINVDGIQTTIDTSIIELRFTATQRFNFWPKASLHTQWPGPGIAGDPVFDNFYASTVPSLDSDEESSVKMKAAGSKLLDQIGKPIILLTHSQSGTHGWILADSRPSLIKTVIALEPAGPPFINAVFPPLTLDRPFGITEIPVNYSPPISSPSELQREVVFNSTSLGITCFRQASPPRQLVNMLGIPMVVITSESSYHSEFDRCTVEYLKQAGVDIEHLRLAEDRGIKGNGHMMFMELNGLEIAEKVVRRWIREKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Z7</accession>
    <name>A0A8H5G5Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_004789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Z7"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="149"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="950"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5358964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118397" checksum="85521D5FA9FBA556" modified="2022-01-19" version="1">MHLHLASNPRVLYLVTDSSEERSGLPGRALVFRAGENHSTQAIVEFLPKSEVNLVNTVRLTTRGIRGCLGLISIENDIFLALVTSATDIGNTRPSSTTPESVARIHEVSFFSLTSPIWDDHTADSMEVLDDNANYTSTPTTFEHPCVPLTKILSSGSFYYATDSSWDLSSRLARRLNRNEKTHRDLAIFDERFVWNEYIARSLLDFRARLDPHERDDFDRCQFIILAIQGYVGTFTMALPAPPTNGAPTIATLSLISRLGSKRAGTRFNTRGVDDDGHCANFVETETVFSNDQHCVSYVQVRGSVPLFWEQQGIQTFGQRIQITRPHASQPAFERHFAQVTEEYGAAHAINLLGAKENETILSAAYDRHLQIARGVLGDSISITHFDFHNQVRIGGHDSVMRELRRIEDITDHIDKFGFTMCDAGTDEIITDQKGVFRTNCLDCLDRTNFIQDILSRTTLESYLLLVRREWILAQALWVHHRELWAENGDALSKIYAGTGALNTSFTRSGKRTLAGVLSDATKSVSRAYINNFQDKAKQTAIDMFLGNLSTQRQVTIFDPIHDSVRAALDNRINEYSSMKKCIIFVGTWNLNGRPPSESLLSWLFPRESIEDPDMFVLGFQEIVPLTAQQIVQADPEKRRVWEHRILDTLDRRPNKKSSYVLLRSEQLVGTALVVLVKSELASVIRNVEATSRKARIQSHLTGLRGMSGNKGAVGIRLDYHDTNFCFLTAHLAAGHANVEERNQDYWTIVNGLRFLKEKTISSHDNIIWLADTNYRINLDNDTVRSLAQTGNFDGLVAADQLKHVMDLRQAFVGYEEGPLLFRPTYRYDLGTDNYDTSEKMRIPAWTDRVLYRGRQLDLSVYSRAELKGSDHRPVFSIFHANVRVIDGAKRAHLSKLLLDSVLSTSPGENLDEKLASLSLPDDYKNSEYPPPSSDTAAWWNGADHPDGLISFSEFDPSKHHRHTNPFDSPTDTPLSSSPSSSDEELYTHALSLPTSTMITTPTLKPTVLFSGSSSASPEPTITNSANGTGDSKGPGATKRPPPPPPPRSTKPGADNSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G619</accession>
    <name>A0A8H5G619_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G619"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="9">
        <location>
            <begin position="101"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5358993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="35562" checksum="71B07B14D9A21A4D" modified="2022-01-19" version="1">MARTRIPTPHGPAFLHLYHNNRDSKEHMAIVVDPAQFQGPPNPDSPPHIRSKTLDAVWSDNETEMDRITRGAYVGRLSADSQHASNPIHAHTHWTGINDLIPSPLIRIHSECFTGETVGSMRCDCGEQLDEAIRLISQPIPVPSQSPLDPPKEIPGRGAVVYMRQEGRGIGLLSKIRAYNLQDLGHDTVTANLMLGHQADERGYEIAVAILRDLGLGSKDELGEGVRVLTNNPDKVKALEDEGLRVVERVPMIPRSWRSRNAMLAVPALPADRQSPKDDRIPGATLIGGNAVYGEDLDKYLRTKVLRMGHMLPLWLEDPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAE0</accession>
    <name>A0A8H5GAE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAE0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="288" mass="31840" checksum="FCF08503E9B6A9C3" modified="2022-01-19" version="1">MVGTQGGVVTPTRLENLTRLDICVGVPLDTPAEFETHILSILNLPKLVSLSLSYNNEEYNDFVSVKPKWSQTAFATMISQSLCSLQSLFLRISISTSEMLEVLRLTPKLTSFTIEATYRGGRHLDPAQVLQNLSSTTVGLDHLTHLLSFQNPVLTITNDFLRLICDMLDTRTRTISTGNRISSSSGRSSSSSNSQRGEKVDGGDEDSISSELEFFRLKTAFKDFGDELPLMARFEALASLPGKDFALLCKERRRIYYDTESEGDAEEGREDSDAGGSDQFIDDGTPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD31</accession>
    <name>A0A8H5GD31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD31"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53587" checksum="90EDE8405FB6D2F2" modified="2022-01-19" version="1">MLPSELTDAVIDCLQDYPSDLKTCSLVCHDWLPRARTNLFHDFTFPPHNSTLSSDPDSKKTKMAVKAVVDVMTNMIDLATKFDLGSPIPALVKNLTVDGRGSRVLLDIYNTGFLSQLPFTGLLHISIYHCDSETYAYTPSQRCLQRKSLEGLLEKNLHLKSLGIRRVWFERIDDLLGIVEDSTNVSHPHFRSLTLDTIDVVEMESGADLHVPLPISAWQNQGGVIGLNHAHGGAHAHVSTGLVHLPGSSTYLHISELKFLGNMPWLPIELLCTLANRLLDSSHPQDSDPEIAKPHSIGSVHTVSVFDVNTLDAYVGIFRTWGASISCLKVELRPVINDMHSPDAAKSFPVLDHVTHLELYTDIKTRKYDLKLEVFTSCMSKFLPHFPHLKKLSLVRVPASGHRDWRTARSSLSKTTSRLAWIEADTNHDQVLEDLSEAELQKALGLLRLSVKLEKSLKEILVELDERRSGMSFEYAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE46</accession>
    <name>A0A8H5GE46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE46"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5363085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="36400" checksum="BB07DF24A6FF4FA2" modified="2022-01-19" version="1">MPAAPPSQYIPTYQPMPMQPPIPPPNPNQLIGVHPWNVVVQHAHPLNGFVPPRVPDQTFGIGQKVDFWLSVPMLKGEMNFTEFRQRVEIAAKASGVDSVLDPQYANYCPMEPLPNDPDYEANMHAFRSYQMLEHQTRALLISKVNLHKWLEEDEDIIRRIGDAGGIISDQERKNHVLTSIPLITRELSTQEIIDLLCSRYLFLHPELPSWSTSSTEKSLSSSKTSDPAKDPKNVALQASSTPGGPSTSTAGRSGVSMETQCYNCKGFGHLSRDCPTPKQKPNGGGNGCRGKNWHGRGCGRGGGNPGGHGGANMNNGGNAANFEGTPKAGNTIGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGZ3</accession>
    <name>A0A8H5GGZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGZ3"/>
    <dbReference type="OrthoDB" id="2679012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034202900" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="75" mass="8475" checksum="EAE4AEB86E65895C" modified="2022-01-19" version="1">MQFKVLVLLSVAFMIVAVPLAEEARTVDEEESFSKRVPHTYKIIEDESLSKRVPHTYTIIEDELAIIESKGAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI11</accession>
    <name>A0A8H5GI11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI11"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="3">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="96" mass="10838" checksum="F475FF246872CDF4" modified="2022-01-19" version="1">MMVVLLFYHIDFTFICTTEILAFSDVHFQALDTVVLGVSVDSQYSHYAWANQPRKEGSLGSDLKLVLIAYRNRNISGEYGGLVEEEGIAWRGLFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI28</accession>
    <name>A0A8H5GI28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI28"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="123" mass="14456" checksum="4F94C70AD4EB38C0" modified="2022-01-19" version="1">MDPPRPHARSHNQKPFNLREEFDRYWLEHHSQLFLSLDIVKKNVLKYEQLHINQQTKALLQSLGVALIECDGVGLIEAETYDKIFEVFNDAQFKALIEPDEENFLDRSKTRSIPLDFVAFIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKS2</accession>
    <name>A0A8H5GKS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKS2"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034592218" description="Carboxylic ester hydrolase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5366747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="55732" checksum="B7C75BDA6F19C947" modified="2022-01-19" version="1">MPAPLLLLAASLSTSFVNYSGSLVAGQLTSNSAYPVADFDSKCSSIASQLNNSIPNATIRFAELVTQGTNITFTESDRDPSCVVEPFFLPASLIVPADVCRISLDVQTSGRSGIHMETWLPRNWTGRFLSTGNGGVGGCIQFPDMTYTSSLGFATVGANNGHDGFSGRSFLNNSDVLEDFAYRSVHTGVVVGKEVTKTFYGYEHTKSYYLGCSTGGRQGLKSIQDFPEDFDGVVVGAPGNQWNKLMDDFSHIFNLTGTPDAPSFVPAEAWLNIVHPDILKQCDKIDGVEDGVIEDPHLCNYDPSGIVCSEDSKATSCITPEQADTVRKVFSPFFIGDEFIYPRLVPGSEISDALSMVLAGDVASAEWFKFVVNSDPNLDVKTLGPSDWKKCIAQDPFNISTFKGDISAFKNRGGKLLSYHGQADSLVSPENSEIYYDHVSSTMDLSTSQMDDFYRLFRISGMFHCFTGPGAWNVGQGLFGDTSPGSDYTDPKNVLMATIDVRARAGPEAPGLGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL49</accession>
    <name>A0A8H5GL49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_004054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL49"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5367051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="452" mass="48815" checksum="83AC6E782AFD9E67" modified="2022-01-19" version="1">MLCSLARPRVPTTRLHTTSSSVCRDHLIKTLYLDISRNSAIYTHSSFHDNARMFSCRVDYIESSFVPFDVANVVDLLRNLPLSILAMPGTHLLPPNLLKLFAPRPPLPYSRPVDKDIDRIRSKNVSGVAAILAQLKETATENLAADDQMEEGEEPVFTLAEEAKRQIRREERKKRKAEQFRVAKDSYKPSDDPEAVGDPYKTLFISRLQKGATENDLRREFETYGPIERVRIVRDKKSRSRGYAFIVYERERDMKAAYKESDGLHIMGKRILVDVERGRTVRGWKPRRLGGGLGGRPKRVEPLPMPSRGGGGGGGGGFRGGFGGGRGFGDRGGGFRGGRGGFRGGGGGGGFGDRGGGGFRGGYGGDGGLRQSDNGYRGREMGGGHRGGRGGGIGYNGGGFSDQQNGPPVGNGGFNGPPSGGYGSSGGGYGGGYKRSDAPGGYDDRESKRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNN4</accession>
    <name>A0A8H5GNN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNN4"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000853">
        <property type="entry name" value="Related to ARK1-Actin Regulating Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="590"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5368418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1250" mass="135820" checksum="B8E40B76B8E3E0B1" modified="2022-01-19" version="1">MSTPQAFHPYQQNKGPLAPGQSISVNKYTVQVERYLSQGGFAHVYLVRTATPVYNTTHHVLKRIAVANEAMLTAVKKEVDIMRLLKGHPNIVHLIDAAWHRMSNGLYEVFILMEFCQGGGIIDMMNRRLRERLTEAEILQIFVDVCEGVAHMHNSRPPLLHRDLKVENILQSSPTSYKLCDFGSATTVSPRPPSNMQEIRLLEDDLNRHTTLQYRAPEMVDVHLRRPIDEKSDVWALGVLLYKLCYYTTPFEEHGPLAILNVQYRIPPYPVYSPQMNGLIGMMLREHGTQRPSVFELLAHVHTLRGTKSRFHYTIPTPQPLSPRQSSFKPAPSPNHLESTISYRQAPSMASNVGTNVKSPVNAGIQARDKVLEAIAPMRRGRPTANKESSLSRPASPDRNTPDSRSKQKNWLDDEEQAWEAIASKGSGKAGKPSDDAWALPSDNKAGKKAGDQSFGDDFGEQLWKAPNPNAERKGGTPSAAASETSVKSQPARPPLTTRISDQPLTKPMSITRTKDKDAFDGLGLFSNEKPAPTLAEARKLRTGLALMSPSTSNANSSLWNESGKPSSSRPPYSTQSQTLALPPAPPLQPSSSGSSWSSQPPTSRPSSSQQTPSASAETRFPSLEELDATFSSGSSPAHLPVSTKAGPHAASQPSLSKASEVQTQHSNTSFVAGRSSRLGLPSGSSGTDGTRSEQITGIAMRGGASTPGPIPTSSNDHSDRPSLARGSSIRRHRSSLTMKQTSPQMETSPTPTTRAYNQESSSTSTQRDWLTGDDNISEVPPPSPRSTNGPVLRDSPSKRASFIQKSTIQYQKAVPVTHDRAPSPSRASHILTIPNSATSAEPDSPSTRFHRVFPELDTTVEPSKSLIDNRSPTDTKAVSASKRYQEPVSSGDEEGPEEASGKYIPSATNQDSRKSRQKGHKGRQSSVHDLVDLWGGGVTKEKETARSTITPAPNPIVLDKRRSLAAPPSPRKNSLSPHHSPTYLETPSTVSSPPLASPTSSTSSRSRPQSMFLFPSKGGDHSISPPASNSMELRSPTSSSLLPPADPQPRRTTRRTSISDMVQRYETIDATARGSTPKPAAVRVSNLPTPDNLPPRSPAIRRGYSNGKPPSLLDDSVEEKQTMSQVRSVSSSIPKSSISGLPRKASPAPSESDKTQEGEPPARLRQPSTKFESTTPFPSQKPVTEDIRNPQDTRSPSPERPYQGVGRLIDQWQRKTAETEATRTPVPAKRGGGFVAKRAGIVNTGTSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPA9</accession>
    <name>A0A8H5GPA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPA9"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38242" checksum="A5AACB49D62BE245" modified="2022-01-19" version="1">MTSSLRNSLHRRNHKERSQLAHRARLGILEKHSDYVKRARDYHSKQDRITRLKQKATEKNKDEFYFSMTREKTKGGVHVKDRGNVALPTDMVKLLKTQDENYVRTMRASDRKKIDKIKNQLMSMADLLKPIGGEETEGLDEEELQTLRDAGIISGPSRKRARHIVFVDDEAAAQQYAATLNSRSDQTATEEASPEQEEVDLGWAEPQKKRKSQQRKRRASQAEEEVMEDEDREEAPSVQTRSRLLKELSARLVRDRQLRYAEREFELQRAMMGKGARRKISAAEKIEGDDSDDDDALDARGGRTKRSSTRVDEATYKPRVYKWRVERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPB3</accession>
    <name>A0A8H5GPB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPB3"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="201" mass="20765" checksum="D950F2431410BC97" modified="2022-01-19" version="1">MDKFMNLAQHGLDAYQSHSNVQKTGGAEFNSPDNKPPSSSLMNMLNHDEVAEKASQNGSGGTDLFKSAMGFLNDNKFEHEKPIDEEHVTSSHKAAYTDGNAGSLGASSIGSAAALEVLKRFTTGSESSSSKSKTDLISMAMAEASKLFDQSGGATSGNKQDAVNSAGMTVMKLLVQSKFGGGGAIGGSNSGGLMSLASKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPJ7</accession>
    <name>A0A8H5GPJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_002854</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPJ7"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5368851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45392" checksum="6C09A4E4F4C067BB" modified="2022-01-19" version="1">MRRASESALGPRMAANYHRKQTDESVLMVFGILNKPDSWRYQANRAASSVLLSTVYDLPSIQSPDDPSIAFMEDFVHRTTEAMLPGSHLANVFPILDRLPDFMSRWRLRARDDFERYTRTFKDMFLRVKNKSVNGMEERPSFCATLVEQEARHGMSDSESAWLAGILYAAGQETSTSVLHWFFLSMVLFPEVQQRAQDELDKVVGHSRLPSFADMKHLPYIVAIINELQRWRTATPLGVPHAVIEDDYYEGYLIPKGTIVITNVWSLNLDPEIYGPDADQFRPERHLDENGCLKDPKDDGHFTFGFGQRVCVGRHVASNFLFITCAMILWAMRIDPAKDVKGDSILPDPNMLKASNGVILRPTRFEFTAKVRFEDAGALIQQASDEILRESTVRLKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPR8</accession>
    <name>A0A8H5GPR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPR8"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="297" mass="33138" checksum="B780EDE00A2AAA1F" modified="2022-01-19" version="1">MPSYNPCLPEDLIRRFKSDPHHKSTLIFSKCVETLRLEVLVRSPNRGSQDREVSLAEPEEKDRRLQPILDSLTGLLKNLQNFQLGARKTYLHLALKRVDLPLAYEMIRMGVTIDIKDKDGVTPLLYALATLRGLQASLETVTDPSFSRSSLRNVPKVMQDSLKPAHIKKMEEIIARIAILLIEQHADLDTEAFGWTPLFLTVLAQQWDLVKLLLLHGVHRPDLHDSRISPPDRHQLSSLMNEVKAANPRPPRPCPCWSGKPSPNATTLLLSPILTTSSAVVVSTGPLVLVAENVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPY6</accession>
    <name>A0A8H5GPY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPY6"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="178" mass="19751" checksum="45AD5DEA0DADF398" modified="2022-01-19" version="1">MSTAPKASTSHHRRPNHHQQQPKSQRRPQPQLQESEQPETTTTERDTDTQWQPKLAFANERTFLAWIHFTVLLGGVAVGIANFSHSGTGTGTGDMENDLREGSPVTVTVTMLSCLAIAIMLYALFTHNRRASTIRRGIPPESVYVDRMGPTLVLAAFIAVFVVNVILRDKEFGLGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR97</accession>
    <name>A0A8H5GR97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR97"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="386"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136277" checksum="63FA2DDD65FC268C" modified="2022-01-19" version="1">MLVNARDDSHIASPLSSSKRPPFTRSISDTPTIQASVPSSPTNLSPPQRPPRNPARPPSTGASFFPPVGKQAESQNGRVSRPRTATGTREEVTPWELYPPPPVVPTSALASQAGPSTSKRVPGTQAKPARPQSSSGSSHSPSLSFGEFSLLRRRKSLGSKPKSPAHVLHKPRAQPATTSTLKPAELPPQSQSDHDTLTRPLPGTNPTSSQQSSGVVTSQSNLHTLSPPSTTQLHHTPPHHPHRHPPHAEDSTGSNLHKPPSPVSQKEINLKFSTADRTILEELKRSINAKASQFVLKGAGGVPTPTRDSSSSFHRFGGASSLNTSTTLWGSITGPRKHHPYPKDEVPYPKSYEREILDLDVWENLFCQQVCKSVTWHVFEKAPSKVLDIGCGTGTWILDCARVWRQTHFVGFDVVPLHPDLQQVGSADLARRVTWHQGNFLEGLPFPNEEFDFVHIKRIGMGVPEDKWDYLFEEITRVMKPGAAFEMIEEDLFFPGRIDDDDTDDSEMSDDQLHHLTTLRRRSLKRISGLSSSTYRYNGFPRDEPWSDHEREDNDQEYDSDIPSSPSSRRTVGGRVSDSPTNSVQLSQRPPSPIPAPPIAAIAEDEEGEKTATLPSPVDTEARRFHLLDPTVTTTSTVTNGETVQSKRRRQSLSRTTPISIPPNPYSVKSLPSSPTTGRSVLLPLNTRALPMSSAHGAAHLSLFLPSKPQSVSQTKLTGSTTSLHQVPHSSPLSASSTSSLFIPSTRESLEDTTYIGSPSSVSVNTKPAVTAPLLLRTLPKPPTNPRDHSLLEMIYQEMHASRFINLAPLSLLPNLLGIHFKDVRTHPPLQFSFPPPTPTQDKRASDVPSLSDSSVIDSDPDEEAHDAIRPAPSISPQNSRVRKRQSTLSEHQRYPRISSPVSTEFSDAGSGDEEEPRWISMQNLLTGQSSYVSIDGARASAFSPSRRASFKGTRSARKSSNASMTDGVPGRTVDAPSSAEPPSGLPAGDPTMFPLRMPNNNLNVDVRSLNLHLGVRVGDVLGCTESMWEWVVEYQRKTRRQKTTRGEGAARARSRSIDFAPSREPRLSSAERLKNAIMDLTREEYDDLVKRFYLDMTSHIAIGSNLESNFAWHAFKYGQSSERKAFEAECAKYNQWEREQKHHHHNPPPRRRSRPLSASLSPLPSIIDLPTPKEMAEGPLLNPERPFVQNLRESLISTTSKSRASVAVPKSPSLHSTLPQSRRKSRAMRVFVAWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GST9</accession>
    <name>A0A8H5GST9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GST9"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="61679" checksum="9F3BF1326A6D3676" modified="2022-01-19" version="1">MSSVSESKQPEPTTPPFASPLPGNYRDGRKSLRNTVSQFGRKVTTRAGWFGTDYNYSWLCMPTLPYSRKKQTLPPFYALDADLPLALAISSGLQHALAMLAGLITPPIIFASSLNLDSETSAYMISASLIASGFLSLVQMSRIKLFGKYCLGTGLVSVVGTSFATLSTANAIFDSMYNDGTCPSTTSAEGTMTREACPDAYGMLLGTSLICSFLEMFMAFVPARVLKRIFPPMVTGTVILMIGASLIGSSGILNWGGGSNDCSSSPTTGIFQLCPTINAPRPLPWGSPEFIGLGFLSFITIILIELFGSPFLKNISIIVGLAVGCIFAGGFGYIDGSSINTAPAITFLWVHTFKIRVYPPAILPMLAVYVSLAMEAIGDITATSEVSRLPVDGEEFDSRIQGGVLSDGLGGFLSALLTVPPLSVFAQNNGVISITRCANISAGRWCCFFLILFGVVGKISGVFLAIPNPVLGGVTTFLFANVAVSGIRVLTYSTFNRRERFILAAALSFGIGDLLVPTIFTHLFDGVDQPSKGLKGLFDSITIVLSTPFLAAGLVAVLLNLILPQETVMDEEGESGTEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT86</accession>
    <name>A0A8H5GT86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT86"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="54995" checksum="FF2B2AFC03C30C8D" modified="2022-01-19" version="1">MGSSTSKPVSIPAAVDEKRAVAEVAASLSTLSLATPTSSDGSLTLSNISSWEEQINADSKAQLARTVLVHSNIRDALVSRQSHIDTTHIFNHEIDFKTDPVTNQKSSGRCWLFATTNVLRYDIMKKLKLKEFQLSQSYLFFWDKLNKSNYYLELMIANADLPIDDRVVNHLSGDLISDGGQWDMAVNLLENYGVVPQAIYPESTHSSLSGPLNTLLKTKLREDALLLRKMSAELKAASVSADAVTVALRAEKEKLIKEIYKIMTAVLGVPPMPDKKFVWEYYDTDGKVGRWEGTPLDYFKAFSSKNYPAKESFSLVNDPRNDYSQLITIDRLGNLWGGRPVLYVNTDIENMKAAVVKMIKAGVPVFFGCDVGQSSERTAGLMDTTLFKYETTFDITLGLTKAQRLQTSESAMTHAMVISGVHLDVNGKPVRYKVENSWGDAVGHEGYFVMTDDWFNEFVYQVVVPKSLAPKELVAIYESGVAKVLPPWDPMGTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTA4</accession>
    <name>A0A8H5GTA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTA4"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="102" mass="12275" checksum="FBD4A2460A27D6B4" modified="2022-01-19" version="1">MQWHVLISCSSPTRSQVKSYYRYGQGTVCGAKLQDWKFCLGLKFLEPEEQREAWIRRRAEWWARRRLGKSSEDVWEMRTEPVSNFPKPMSETDMQLLKEQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTU7</accession>
    <name>A0A8H5GTU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004103</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTU7"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="149"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5371104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="723" mass="79851" checksum="0FACB443D20A6DFE" modified="2022-01-19" version="1">MAKSHERPDSPSSASLPSSKKLKTSHISTDDTDVTSAFANGVLDPANISQLHKTYLDNQPFHFALVEKLFQDDLLKHVKDECLAELSFTEKQTDIYKVNQTGDLASLNYLSASQISLLPNLLKLRDALYSPAFRSFLRSVTGCGPLSGTKQDMSVNSYTKGCHLLNHDDVIGTRRVSYILYMPLPHYQLWQKDWGGALELYPTKPGPNGVPEPVPVPSKSIPPSWNQFIFFEVQPGQSFHSVEEVVVGGENEGRERLSISGWFHAVQPGEEGYVPSDEPELKSSREQLTESKTDFKAYDESSAPPYPDVELSNEHVTFLSEYLNPVYLQSRTMSALAGRFLEESSLELHSFMTNELAVALELRLRDLDSKDGLGPERRGKVPPHSAGVNLPDSLQPPSTSAESGINTNVNIIPQNLAPLQNGLNGLNGVLHSNGSNPRILSPKKRLHRVSGTSKVLRTNGDIALLSLLRQILRTLQDELFPSEAFRAWLAIVTKLLPLRHFVEARRFRPGLDYTLATSEEKEARLDVVLGLTPAALGGDEEVENAGSSRSRRVQPKEVKTWSAAEWGGWECYMAPHNEEDDPAVYRAGTYRKSDVLNNGNLKNPPPSTNGHADLANGSHNGAGHPVENGKEDADVDTDDDEDKENQEADAPMEADDDEEDSTLLTVQPGFNRLLLVLRDERVMRFVKYVSAAAEGSRWDVCGEYEVGMVAEDDEGGDTVQNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWG5</accession>
    <name>A0A8H5GWG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_005084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWG5"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="69"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5372175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="757" mass="84900" checksum="AC66A0DC6E36C8A1" modified="2022-01-19" version="1">MSIFSLFGQPVSMSKETQTKTLEPISQATFVQQRDKAGLLVTNELEKALEDCKAKVNRISKDCRMRNRKFRDPEFDIENDKTRCLNGLGEGDESYTPSDIQRISEIFENPQFFVDGADSADLVQGAIGDCWFISALATMATKKGLVERFCVARDEQVGVYGFIFFRDAAWITVIIDDLLFTSIPKYEELSWAEKQLYHGDKELYNKSARKGTKTLYFAKSSAQGETWVPLIEKAYAKLHGSYAALSGGEACEAVEDLTGGISTFIPSHDILDVDRFWNEELVKANQDRLFGCAYQTLSGARSGDWSSKIMGLIGNHAYSVLRAVEVKGKRFVVVRNPWGESEWTGPWSDGSKEWTKEWMEVMHEFGHEFGEDGQFVMEYKDFLSCWDTFDRTLLLDDTWVLSSQWLHVTSRPLPSAWTFGDVSFTFSVSQPTLAVIVLSQIDNRYFNNISGRSHWQFDFVVFKKDQKEIVAESSHSRLYARSVNLEINLEAGDYVVHVRFDRTQYRDANYYSNKASDWDQRTLSRMLTERAAGRSIASNFKAESEKQHLHVPIDILAGQDLAQLETKALAIAKAKKKEEEEAAKKKADAEAEKAKKKAEAEAEKAKKKAEEEAKKAAEEVAKHTPEGEKSTTTIVNEDGSTTVTTTTVVKKMVSVTTKKTEDGEEVETKEQETTMAASASTSAAPKLPTGDDDDAKSDASDDSDDTPEPDPLRDVMDASEEDSIFLGLKVYTKKEVPVTITGQLRHEMEVSAKLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXE8</accession>
    <name>A0A8H5GXE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXE8"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="358"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="636" mass="69678" checksum="87166C8400E98781" modified="2022-01-19" version="1">MNVLIYSGPEVLPASLKHTLSVFRRLLLPNYSVQPISIQVLRTQPWSISCALFVFPECRSAVASQFTRTINTYVEGGGSILFLSAGVHSPSRTRSESIGSITKLHTLSDQILRFLDQKNGTFIYPIWRPGIARFAEVQIPDGPVMKHVYNSGQTDFAEIENMSNAQVLMTYAGEDAGKAAVLEYRVGAGKVVFCGVSPEYPLAEEPSVLVSGGMSENDISLAEAQRKEILTHILSRLNLSLSPSPMMISRPFPQFLVSHPAQSGLISSVLGSLAHPSSGSELKTFEDANDNFLFCTLDDSGPLLTQTRQFQVQASDPSTWQPKHVIICPDGKLPDCTQTPLFDLDLFFETISSVRAKEGCTSQLGTWGCGEVMFYSEAVTSTQTMLDKNPRFLAQLPTPMLSLASHQLSGRGRGANSWISPPGCLQFSLHLRVSLSSFPANKLVFVQYLFALAVAEACREETVLGKLGDAVRVKWPNDIYATFGRGEQDRKKIGGILVSTSFSDGKADIVIGCGVNVLNPPPIFSLEQLQQSSGSPLSMENTAATIMSKFEKMWSIFLESKGNFEPFNSLYLERWLHSDQKVLLTTVDPPKAVRICGITMDHGLLRTVPERGEGFIDLQPDGNSFDLMSGLIKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H096</accession>
    <name>A0A8H5H096_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H096"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5374237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="684" mass="77001" checksum="03B6282835A94F7C" modified="2022-01-19" version="1">MTNPLKQLEAVFAKLSTDEEKISAATSYLQSSSDRHPVFLNSSGNTTRHCQQDPVERDALEFVKLMEKHGIQHDQVMPSILGEPTRRTQTHLDQLECANHDITKARQCRNKATKVCSGCRLVSYCSQECQKVHWAAHKRDCKHSLKSKEWRPKWVQDRRSPVFMMTSSAQGWEGQQMFGMCRSLWGNMPALDVLNLENNEGHHRAVQSDFSLAFVASGDLRNVLKTVNGLPDDYNGTMNILINDHDPMVVCRNILVLAILGLGDDVEDAAELALHLWYSVFLPGDAWAIRSLKLYQELGILPSAKATSSHRLLSFGSHSSLNVVFDDETLRTMLTTIATNTISRLTPAVANNALHNVMMAPQRVDYRHRYYLGLEPSHRVAFQEWREFGIVYPFGGCSAHLNVPNPWLFSPDHRLYLNDSASPYQGWDVPAIFEAGKAHGTTREDLIGCLYFYLKDQLLKFAYRLRSFKINISVVNCDALNLASRVRSGSIPGIPRTIAFDRIEVSNIVDAEYVGVKRVLEVWGPLLKSKDVNEHAALIGLFMNWALTTPGATIEGMSKSASATLIDMFATQYQDLVSPLALSRRGQLSPDPTGMMVILGNIEICNENSKHFHCYLRDKGALTESKTAGLQAREKNKIVPHRLGAMLGSPHKSLPQKLIGDERYALMSLYSCTWQERYVEWKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0I5</accession>
    <name>A0A8H5H0I5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0I5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="23188" checksum="2AFAE7FCE30A91B4" modified="2022-01-19" version="1">MNRRIFMRNAYTLSEWWTSQGDGQGGYGGSPGRCSDREIEGHSALWKYSRFTPVQKRPTKMHSSPPCLSPCNGTTGNEPMALRSRLSVIPTTQPFAPTTTTTLPLQDCDCHETHSNALSFPVDASCWFFLATRLHIWNRANINHIDLDDFRVALPVYKPFFSSRFSFETQPSPWTRPEPFLRSLKEDSREDCRRRRLWAGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1S4</accession>
    <name>A0A8H5H1S4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1S4"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="704"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5375118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="956" mass="107004" checksum="312715D4B8890930" modified="2022-01-19" version="1">MPHEDSKHLVAKFYQQDVVAKAGSNSFGIVLRCWHDAEDMAIPPGAMSDPLMRPLKPGEVGVSWLNENAHSREILPESELQLLDRTLQPGDFCKRSVDDLQSGVVTNIQTRCRIEHVISKEPVEGWKTSDDFQHRTDADIGDYVVYNDWVGQVIEVRNRPPAILRHKIYSYSSLHQLFDENIIEVPSGQLVRLPEFSSRLAVGEKSESILPPPGGMSNMLGFLFGNTGRSGGLETVIAVKHTVFAISWLAINQTLDAKEAQSRQRPQRFWYGQDISKLTLLQSRSDSQNRIGDRMNLKNSANMPFTKHGQEGEAGGVVSVQCFNVRSTETTLNVLWQDGATESLSAANIIPYLNPDEYDCWPGDHVIWSNEGVRTPVVVQAVDAAQRTAKVLFTETGKIEMVSLLELDPHGTSDPELPQGGLDGLGLRRGDFVFIHNEDTTNGYTPPRVPKIGELESWVRENPFAGGTNQLSGWRKEMAALGTNIATRRGKDGVVEGQMQRSPENGFLHWIGEVYDLNLDGTVQVEHPDQVVKTYPLTRLTKLYDGIEQLEDEMFEGEGMSSPFDEEESWVMNEDGDWVPQEKSEDWEEYEDEDDFMESDSIDSDIPDTVMQESELLSESQMHAHAEGIDILATPSDSLHTKEVNSEDLPTANGDLVDQSEDIDMSAGPSQEGDKAPWKRFEILPQAPPDHAYHSTIPTQPSRSFLSRLSREYRILMSSLPDSIIVRAFEDRADLLRCLIIGPHNTPYEDAPFVIDWMLDSNFPHSPPLAHFLSWTNGNGRVNPNLYEDVLTQPLGTWAGDKNETWSASRSSLLQAFISIQGLVLVREPWFCEPAYEKLRGTKEGAINSRLYSEKAYVLSRNFVFRALNIPLGGLESEIEWIYFTNRKLEKVVSNAKTLIQKSRDAPSSVTMEDEQEAAAVPRLTAGGIITLERTLTKLQGLLDTHSKINSSDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H250</accession>
    <name>A0A8H5H250_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_000084</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H250"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5375269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57465" checksum="7FA56FEC14829048" modified="2022-01-19" version="1">MSYDYLHISLLLAAALLCFISLTFILHLVSVRWSLRHVPGPKCSSLIWGEEWLLYHSLPGSHYVKWHSQFGKVLRFTGAFGHQILSITDPRAITFIVGEGIYSFPKPTGVREWFKVTLGEGILWVEGKEAHERHRRPLAPALSTQSVRNLTPIFYETSAKLASQWAKLVDESTSDKTEIEATNWAGRFALDTVGRAAFSYDFDCLSGEKHALADALDGLTNNENKLSSFYMRALFWIFPSILSIGKKGEMIRLTKQELGDIAVRMWRDAKIAGDTNEKNVMAMMLKADASGATTSDEAHLVAEMRTVISAGYETVSSTVSWVLYELATNISIQEGVRKEVSTGGDPSFDELNNKYPLLDAVIHETLRLHPPILENHHQAAETISVPLSEPIQGTSDMYLVIPKGTILEIPVNVVQTDPAVWGSDAEIFKPERWIERKEKGIRQQREIFAFSEGPRSCIGRAFALTEVKALIITLLRQFSFTSPYEIEPFQSFVIRPRIKGQGPSSLPLLVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIP3</accession>
    <name>A0A8H5LIP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIP3"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5358806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="299" mass="33122" checksum="BA1FBA92A6FDB243" modified="2022-01-19" version="1">MATSVHIPILERLSIFPSLPSASMYVFFGLLLTIFVFRESLKWKRPRSMMSRIPSSSSTISSLSATLNSDKEDKPLPLRSLFIYPVIISISNYVVLGFLNIAFNALLPLFMSMPLNIGGLNFPPSTIGYIMGSYGAATGIFQFFFFSKIIRYLGERRVFLNGMMTLPIMFALFPIMSLVAKNYGINFIIWIAIALISILSILLDMSYGAIFMYITASAPNRSSLGATNGLSQTSVSIARAIGPAMSTSLFSLSVQEQWLGGYAVFAFFGCLSILGLLIAVRLPADMWEEEEEEYDENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJZ4</accession>
    <name>A0A8H5LJZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJZ4"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5359919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
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        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
    <sequence length="785" mass="84178" checksum="04CE8235F9DB9231" modified="2022-01-19" version="1">MNGACGPVSKLVCQKEWSSPPPEENESAPSESIYAFVPPETAFVSGSVPGDRGEDQGRDLHTNSNSRVDTTGIVHEATRQIPETEVLLEFSPCHQPERTNRRWPFTTSLDGDEVHTSSMNPPPVIHIQLPVQTTTPSRRCRANPDLDADAGRSTTNTTRVSVQIPPWTTNPNCSTGSPILFICSDLCSSPSSSLPLPSPIFSFNSNPCFSSGSASPKERSSRCPSLRLISRFYIYRETELVASEATYLDLISTTTTTATATTSTTTSTSSSTSIQTESVSTSTPMPSESGSGEDRDGDTANDSQAGSSTGTNHVWSTKFVPSYWKFIYRNVLEGCSDPTSDPSSRSEPYMYTSRYTVVQEILDNGVSDNGSLQGQVVRHRLVYRFRGTGLNLKDSKDSKAAPHPSPVGLELELSPLPSSTVEVTGPEVCEANDMIDLAFLSSSSTSLSSPAASTEVSEPVDHLEFDNVSELMYPTLAELAAYGFSSDSEDDALLGNGAAVCTVIGDTPNHDCHWDQPQVAPVGALNSTLLPVSAIYDPNPNSTCPSMAQELPVGLADFPSAISTLVSCSDDMDTAPQAPSPSVDVMHMASQTKVPVVDETDDSEEFHYFWETENPSAQFHSPGYGMQFQNIEDIDTGSSMLGIGGMGEMADALMHTQHAQWDLPVDTSASMSTEYSLLKHSGSFDPYAFATTSLTGPELAGLVDDVDDSLAPSANGEFIEVPDAFRADSQVCTNEASNEGMIIPAPYDNSDFGFLKFTHASGNTTLTSPVLHPPQHKCCHCGRDA</sequence>
</entry>
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        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
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            <strain evidence="4 5">CBS 291.85</strain>
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        </source>
    </evidence>
    <sequence length="3246" mass="345783" checksum="ED19A03897BAA609" modified="2022-01-19" version="1">MEGDEVETARYSREEKGKWKEIETHSARGTVSSSIASNGTVFQANSSQTLDRKRVKTGTEAYKGLGKAGNEGKESDSLTTPRKRAKANVDGGVGETVKKTRTSGKSQLPTPGNPQWRVVVTPSGPRRVMDQNIVHQSEKRPRQWFASKPEMTAILPELSSKNLVNGVSWKVTPIPIFLLEENNGIHVSRSPNLFDEQGETELEITLIRDFSCVPSDLPYLLHQQSTTQMTAPSVPLDLDELIPFPHSGRSTPSSEDIPLLASVKQRQTPAPPPQLSAPPPPPPPPPPPLLPSPLSQPTISLDDLSSFSPSPLSSLSSLENIPLASMVMTAHPPVVFSAPEPLPSASHTSYTAPSSLPTTSPLAPREETSMSHQRLDDEGETNMRVDQTEVSSSSFAVDSTSSLTDPGLVVLSAQKDACSSSEGAPMPMAVDTESGETMTAQSAAGCTNAISNSSVSADVLGTSDTSVAGTRTNTGTRQLQRLAQRVSTSTTTSTSTPTLAVSTLDSSKKPLIGPNALSSTSSSSSLLAMPNIVTGIPRTAVAAAAHKKRSAASASTSSVAEKDVEAKSTKRKGKLLEDGKDGKETEKRETKKRKPNAMLPPASTSRTLTSSSTSQSKSKAVGKSSLSQSPASETSVVMIKISADQQLSLESSKSKIGSELGERKGREKEKEKDLGSGFGSGPVSASVPSSAKRKTRNSGYFDDMELGLEMKKESREASFSAPIPSDGKRRTKSSGHFDVQQGLESPESVQVKKEKETEREWAGVSLSASVSASAPTVAVASSSSSKTARGRNVKAGKGKEEKEKSRPKQPKVLGKNKRGVTSGSSTASSAPQTTNSEISPTVNRTGSSSTSRYSSLKINKTNPANVDADAGPSSPQALSPTKGKDKEDGAQELITGSSTIERTTMDPPPALDVDTTNTAHGPSSIPSEQFPLPGKDKQRTPLNLGEDKLSQQICTNCGVTHTPLWRRINDVVCCNACGLYWKQHGRPRPLTTRGPSTSYGNPPDTSSFSTAFTPASKFPISSRKRQPENPHVDTTGLVASPSSSPLSSPLTPLPTSPSSINDIPSFGETTAQVGLDAVPAAEMEQEPTTIPSSVSGVDGVSLASCSSTVVPFPTTTPGVQLLADDLSVLPEAGDVDGRSEDPAENMEITTSCVSEPNPQSSSMDVVSTRPEAGDAKARPEAPFETTDVTTPYVSEQKPSTAPKEPEEGENGECYDEGLGVSQAPSAVQSDVPEKYERVLHQSGPHRPEPRFQGLSGPNRNHRSRRNYHGRYYGSGRGQRERSRGSRKSRSPGGGRSSWPERGRDNSFPRRDDLSRREEDSEKASFGRLARSWTPTARHDDPMAQSIALERHEGDSGSQNSATLEPSSASSCHDISTLTTSGASACSTSHIAPIDQTPDMSVFALPQAISDLESQDAEMHSLPTEELLVLVSPATPKFPHRDIPTSSSESSGSLIQSDCRTSSSSMTDLSTLATSPSPHNAPLQQELNNDRTCEQSVKPPVKPTAVVSPNVTPRLLPLTLVKSWSAGREYGDVSQVKPLWMDSAWKRVGEDLRCSMDEVDKICARYPIHIKEEDSDSFARTFPPPLLPHPFYDSLNAGPSCTSVSEAKYLEHQPVLPMLPVNNEFTGPIKTSDNPSSARPHSCNIITSSGTSLLQVEPLHTMGLPERTSTGSYEPAGIPEEIRVFIDAYIENLPLLGAASQTTLSKLWDLSLRKEFAFSFLGLFRVVAVAENFKVQPQVKSALHGGYLRGRAQWTIKLKWEPGGEDHLGLSTDRNLDQPWWSSCLPYTPSSDLMIEDDLAILQAAPTTSESNFILSSIPQALPTPDVTKKDLEIPKEPESDTESSSYYRSLRQSHPNYSSRHVPLAHTCSSLVWLPLLVVDDKDDFNRDPNEFRPSASSADQRTPGLGDGGCFKGWYCARCGRLNRQTMFRRRKCGSSFCSDTVMTPCAVIELDVIRGSAGRIPMFLPINTLPKCLSWIDPRLGEWHDGMKTLTYELQQAQADDNAGTRKDTVVQDPNVRATSETTTTSATQIQGDSSKPVLIKHVFTGNLPRLQVEQTFLLGEIQREVVMKRGEQDSSPFFTFIASTPSNSSADVPLVLSSSTPQKRSHENAFQTLSQSSVLSSTPIPSKHGEGPVKKVRLIANSTAPSSLDRKSHELPSSPNTTPKNGGGSRGKGRGQGRGSGRGRSRSSTPRKMMGRDSDASMLPVTQASLLTGVITPIQTPTPTPTSRKGRKQLSASALASPSTSMPISSSSIASSSRYTNPFSSTRVPPVPWSLVPLVVEQAKGLLEHVGLAYGELVSPDSPDGEKLFEINDLTIVSWTVTGTRKGDDLFRAKDHPIIIMCLGCAVEITLVPKGGFGKPPMKEVFNPGESSGSTLGGTGGVVDVDATTVNSFSDQVKDDEAVDGRTGFVIGDAAGRCEDSTGTVPLETDTDALPTLIVDALSTVVPSCDEDPSALPTLGSVEDVEMVLPARITDTEEQLAKPPLTISDESGDFDSTIVFDNLVTTNTQVASASNLVNHSFPSVLSSPVPSSLKASVSEVVDNDDENTPKSPLFSAPPSPELCSTPPEAVTIGEPGDSDSTIIIDNPATRSLDKPASTHSPANPSSISALVNDASSSVPTPLEPSVPASAADDTKCNSTVKSLLFIAPPSPEICSTSIDTDAIVIDYAHANVNAMQISEASDAVAEVPAVHNPPPSPLPPYPAQNKDSGNVEVEYSDQQREAEGLSLDLLHAAEPLQLQDNEDEIEILPQTANSSDLDSSSQRERQRRLLLLAHEKKGALKHQEVGLGDEKGLLAPTTTLTMATATTNANLASTTIPIPNPTPTVTPTLTLTCPTVDCHTPTAVALDLENIDNTDVNDGATRTRTQVTSQARVGLGLGSRSMSPNLQLNWEAGVGEVEVEAGVETGIVNETLANARARASVGVGVNDDDDDIGEVEVASTMELEVGTVDIGTTADLVVVPENENALEENQDENEKASGENYASGVGMQVEENENENENEKVKVKEVEEGQEGDADPAKMSWLSGQAGTGVGVGVIVGNDAVAIGGRVGDAAGDDSRTDREGVESSVTVPVPDAGDSVIAKPKKRGRPKKERNQGINVDMDSGYGLGPGDGNGPMKEKKKPGRKPRGVKVVALGPEGDMKQEKDEAVDNPKEKEKEKEKEKEEITISLVHGDALILDGDDFEFKLAREGISILLIGTYIAPDVQLTESKTIPEELIPELVPESAVLSQVSSLPMSTHVPGSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LME4</accession>
    <name>A0A8H5LME4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LME4"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5362602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="42659" checksum="D6BBB5D4C3376AAD" modified="2022-01-19" version="1">MSTHQEQAEAAAAAREARLLRNAEATTGTAASALVPSIPFTYTLPDTLRIWPWDRKISPYYRECQADSVAWLEGFKPYSPRAQIAFNKCDFSLVSALCFPESSKFVLRSCCDLMHTFFTLDEFTDPLDVEGVKTLCYATMDAIENPDKPRPEGENMIGEIARQFWQRARKAAPPPCEERFVNAWRSYIASVILQAERRDHSYICNIDEYMVSRRDNIGSDPSFALLEMSLGINLPHEVMEHPTIVALARDTTDMIVLANDMCSYKKEALTNDADYNAVTVVMYNEKTDVAGGIQWISDIHDDIVDNFLRLRQDVIHKTNGFPSWGEEIDRQVELYVDGLGMWIRGHDEWNFGSGRYFGDEGLEVQKTRQVHVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LN18</accession>
    <name>A0A8H5LN18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LN18"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034225774" description="Thaumatin-like protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="28"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="96"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="154"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26208" checksum="023FB52CAD1D5D78" modified="2022-01-19" version="1">MKGLLSVVSLAAVVSSASARTWTVKNNCAFTVWPAMFTDLNVGTSVPDQPNGWEAPAGTSVSFNVPNDWKAGRIWARTNCDFSTNPGPTSCVTGGCNGGLVCDVSTGTGVPPVSLAEWTLSGDQNQDFYDVSLVDGFNVPMAITNNVGCPEASCPADLNPGCPGELALAGPNGNAGCKSACFANLDGNQADSGNCCSGSHSTPDTCPASGVAHYDYFKSACPNSYVYAYDESSGTALWTCDSAKNADFTLTFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQU3</accession>
    <name>A0A8H5LQU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQU3"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="32301" checksum="B2961FA7BEB98E58" modified="2022-01-19" version="1">MILSPQGSRSCHRKERETWTHDRLLHQRALALGHAINPSSKLSYSSATESYIQFCQNHQFPINPTPDTLSLYVAYMCYYIKPPSVSTYLSGICNELKPFYHNIHQTRSHFLVRHTLKGCRKLHQHETWQKHALEQEELSEVYSDLCQSKSHDDWLFLAILSISFLAIMHLGELVWPDSTAHHKLQKVTMRSTLSITDNVLEFSLPTHKADKHFDGNKIRIESTGTDDDPIEIVCKYLESCNHLFPAHLNLWAHSDGSIPTQNWFIQVYDAISHLKSPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSA7</accession>
    <name>A0A8H5LSA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSA7"/>
    <dbReference type="OrthoDB" id="10354268at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="23491" checksum="349032D00CF68441" modified="2022-01-19" version="1">MSESLASKLDRYFLLAGNQYTDLRKDASPLQSYNSRIKDIINKAAEISPDTVLEDTQKAEDVCKKLDVSSPDERVEIISAAFTIINAIMLSDLPKQPETVRNEVKEHYEDSKSRLSRLLVGESQIGEEISDEFIASFTKNPLQYVGKQFILNPDSEAFGNDEALQYKIDKVQTGDDETIVHLRFEDLPDIIEMPLDEAVVALKDSWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSA9</accession>
    <name>A0A8H5LSA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSA9"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40125" checksum="6D20461C2A7B53E7" modified="2022-01-19" version="1">MVYEADGNFALEDKTKLRLFSCFFLSFSFSLRYLSTSPRLLLSYGHGANIVTMGQFFDEIPSSFIQWIQEQHLFWVATAPLSESGHVNLSPKGLDGTFNVLDESTVWYEDMTGSVETVSHLRENGRITVMFCAFEGPPRIASPYFAYTWATVWGLDSAAGYMENAVLADHHFGTPEYEEILPVGKRNHGSRAAIMIKVHKVGSSCGFAIPFYEYKYQRTRYYNYARTCETFDVAHESQRPAEDYGLGQGQEFDPENPPEKGLRSYWKTKNSTGLDGLPALLYASKHQLGPRNDLTLERATMFYNGNSGNSGKNVAPAGWNGMVAEYDDGERSRGLGFFDMKFFTGISIGSHLQCSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTE5</accession>
    <name>A0A8H5LTE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_002690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTE5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003770">
        <property type="entry name" value="ATP-dependent RNA helicase DHR1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="427"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="716"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5369365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137988" checksum="1848E87189C6A556" modified="2022-01-19" version="1">MERFNAKARQSIAGSHKKNKHKRSKSEAVDANEEVYIPKTQEEKELDRKEKLKQQASNWTSKKKKRLEKYIEKKLKKEERVHIFEKLSQSQAQIPSSLHLQSSSTLGTGKAFTHQEKLDKLEDKEVKHALGKRKRGAEVYDIVDADSDEEDEFEQSLDFYGTSEPSDKKADAAATSVSVGSALQRNPDGSVPAPKFKQKSQGKKEKTSFPSWSRKAKSVKQAVQPESDSPFDSSDSAYDSSDEEEGEAEGNASILRKVHEEEEEEEERKKTEAEEDDDDENEDDDEDDEDNNDSDPEPSPPVKKRSLGFKEWAMKQVNIAKGYVPPPTSFEPVLSTPSTDAPLPSSPKKCKTSHQDGKPVEMRGPLGEDLHLPSTSFAAQLKPSRADPDPTNKDATTKPKFFTVTRTPEVEESRLLLPVVAEEQPIMEAILLNPVVIICGETGSGKTTQVPQFLYEAGFGSPGSGIAINLYNIDNPGMIGITQPRRVAAMSMASRVAHELSLNSSKVSYQIRYDATVSSTTSIKFMTDGVLLRELATDFLLTKYSVIIIDEAHERSLNTDILIGVLSRILKLREELWKEGKEDAKPLRLVIMSATLRVSDFASNTALFSAPPPVINVAARQHPVTVHFNRRTNPDYISEAIKKTCKIHSRLPPGGILVFLTGQNEILGVCRKLEARFGKKALEERKKRRKGAMLRVNEEKQEQSDQMKRVGAAQADIEAEEIELGDVDDTDVAFDVDADDVEEDPDALDSDEEEKLDEELGIDVDESEIPMHIVPLYSLLPSEKQMKVFQPPPPGSRLVVVSTNVAETSLTIPGIRYVVDCGRAKERRYDITNGIQAFQVSWISKASAAQRAGRAGRTGPGHCYRLYSSALYEHHFDQFSQPEILRMPIEGVVLQMKGMHIDAVVNFPFPTPPDRLTLQKAENVLMHLGALNKEGQVTDLGRTMSLFPLSPRFSRVLVSGQQHQCLPYVIAVVSALSVGDPFIHEEALLRSDDSDEDEDDNDEALAHLKSASVREKEALRIRRKAFYTSQRTHSSLGKFTSDVFRILSVVGAYEFEGGGLQFCAQHFVRPKAMEEIHKLRAQISNIVETNCRGVDAKFIPHLRPPNDLQLKVLRQLLAAAFIDQVAVRKDRTEKSSSGAQFAMSKGVPYRALGVNEDVFIHPSSVLADVSPPEYVVFNELIRTSKVWIKGVTAINPAWLSSLGKTSLCTFSKPFKNSAGVMMVTPHFGPDGWPLPPVKTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTK5</accession>
    <name>A0A8H5LTK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTK5"/>
    <dbReference type="OrthoDB" id="2972750at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="35003" checksum="E7939913713CD4D3" modified="2022-01-19" version="1">MSSSTTSSSPPPTNTNDNANPSSFFSPGSSPPLILAFLAIGLFSAAMVAVFGWRRVHFGRATSPFHLDPLGRQIDQTGRRQPFSLGDRPKLWDFWTGTPRDGVSLINQERDLGFRADKDEWQRQNKMEGKPEDVKWDNLQPLAVAVTSLDKDNERHDSATNHAHASISPNSLSTTFRQRLRHFQSQYTTYRSPIFRNRAAHDHNNHNHPTSPSQSPEPHSHPQSDPEKRNTNSPSSPSSTKLPVDTTSGPVDVQIAVAIAMPTPPRINKGKRMSVDSDLGDGEDVDGGDKLEYALGFCRVVCNRGRNCKEGKGREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU47</accession>
    <name>A0A8H5LU47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU47"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="471" mass="52169" checksum="9389F0A84BE341BB" modified="2022-01-19" version="1">MSVSHKKDVYLVIGGSGFLGRHIVEQLKDRGDNVSVFDIVQRTEDVPFYSGDISDQAQVATALRRSGTTCIIHTASPPAALNDPALYWKVNVDGTKAVIAAAVECGVRKLVYTSSAGVVFNGADLTDVDERLPPPDQPMDAYNESKAKAEEAVIEANGKGNLLTTALRPAGIFGPGDRQMMAGLYRVFEDGKTHFQIGDNNNLFDWTYVGNVAYAHLLAADKLETPPPAPPLASLKSGKSEIEKSEGEVDDELILNPPDLTPDEMSLITTGLPPMDLTTGRHRVPTSEARPLGPYVDPPPNASTLLSNFEKPDTSYLNRPVARTRFDQLSEVSLTRAKLTNPTKHPLQVAGNVFYITNGEPCYFWDLPRLIWKELDSVFPGHRKKRGYLKMPRSVGLAVAYMFEIIGWVVGKEAILTRYRVTYSCVNRWYNIEKARRVLGYEPQVGLQEGARRMVDWWKQEFVAGRHTIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV90</accession>
    <name>A0A8H5LV90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV90"/>
    <dbReference type="OrthoDB" id="3004360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="13522" checksum="EFAAFF2A23A4FE5C" modified="2022-01-19" version="1">MPAATTTDQTRTSSWDIKDLVYQKTQKKPCLWQVKTALSIYNGKNVVGVARTDAGKTLSFWIPLMMAEANGKTGTAVVVTPLNLLEISNFGGSADFDAGTVPPAYGEGPQTSHHLIGCRLKLLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVY5</accession>
    <name>A0A8H5LVY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVY5"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="21357" checksum="9DE3E66FC996BB96" modified="2022-01-19" version="1">MLSLQHLLKTSRSLAIHHHTTRNLVLAAKPALSTRSRSLHSSRAVRREDPFVNILADETPPPVQVSSITNGGIQLADGLILPSSCIFLEGKVFLWDVPTTLWKDWTKDHFEVFEVVVPKPEILLLGTGKLISQPPPFIREHLNQMGIQLDVMDTRNACSTYNLLSEEGRRVAAALLPLRPTSWQKASTTGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWY5</accession>
    <name>A0A8H5LWY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWY5"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="118"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="46011" checksum="C27669DAF6B22203" modified="2022-01-19" version="1">MGSAGLLIAHNLKKLKVGRKQLGIPYTIFEQDAALDSRPRDWSFAIYWAQTHLGECLPEGVDEKYLSEHAQVDTSPPTANSFIPIFNAETGGLLKKNPSPFSIRLQRRKFLRILSKDLDIRYGKRLAEIHTEEGNVRVTFADGTTEEGKLLIGCDGAHSRVRNFLFGPEKAALRPLPLFMSAALTTLPRETALAIREIHPRNMNSVHPNGCSAWIGTCQVQECSDPDPAKWVFVMVQTWAEDKTKSSSNGMATENKGDVARGMKERTKTFAEPLRSFWHSIPDDAQIWHNRLSDWPTEKWDDRNGTVILAGDAAHPMTFHRGQGLNNVINDVYTLRRALQEKYPPSDTSTTSPFAEALKVYEGEVWERGREAVLSNAENSLMFHDWDKLMQSPVFTVGYRKIGERCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX11</accession>
    <name>A0A8H5LX11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1296" mass="142850" checksum="468DCFF67DCAAA4B" modified="2022-01-19" version="1">MTSKSKPEVEQSVQRRHVYIHPSSSRRRGVRSLLLLVVAATLLISLSSPSKFLRDSLFSESHQSTLSEDEITWKDDTWPIRQQKPWDISTDYPHPRVLEYDVQQGTWLRLDVHPKTGDIVFDMLGDLYCIPGDATLQSTVIQARSVTLGVPHDADPHFSPNGDKIVFRSDAGLGVDNIWVMDWTGCGEMDLRRDDVPPELKEARSTASVDQELLAQGITETIDRRHKRLQREGRAGARMVSNETYRFVTDPRFHPSGDKVIATKWYTSSRSLGAGEGWEYTLPSDDTSPIAAGSGSRIVGRTLPPGWTMDNYGDQQIGPEQFLWLGNDALIYSKNVLRESTGSFEYSQDVHQGIYAIFLYNLTSDVTETLADASPGGASRPELSRDRRTLAFVRRQRDHEVLVLKDLETGTIHHAWDGLTYDLTAISAPMGTYPSFAFTPDDAAIIIWAAGKIHRVPLTTNSRGERISGGSPHTIEFKAHIHKNLAETLSIPKAVDLVNMETKPTQRIHAFRDLRADESGKKVVFRAGNIPVVQVVGKDSPTKVPVLYDDEGKTPYYSPSFIPGTNGNLIIHSRWSDTTFTTLEVADLVNGKAREVEGLPLGRYLSAVLCACKGSKRTIAFVKTGGDYLSGDVVATAHTGLYIGDIDLDPSFSKIPVSNLRLVPTEINLFDSIDLQFIEKNKKLFVQQSNRAFVIDLEGKPVDLVGTPPHFTLGSGKMSGEIAVSTRVSSCLKSWLGKIIGKDDSGFRADNVAFVDFYHVYVVPGSKVKEDEEVWSRPGNSTQGLARVSLDGGHDITWSGDGKRLFWFLGPYLHSLEISKLSKCSSEIERDSTTFGISCIKDLLKYQEIVVEHSTDIARVKKSTTRTSPTSNGDVVVIHNATILTMETGKLETDLIEGGMLVIRGGVIESVYSVSKAPSLSSYLGSTIIDAHGGFVIPGFIDSHSHWNGFTNPHPAKSWELQTFLAYGVTTVHNPSSDNVDGFVERSRVESGQFVGPRIFHTGNVVYGAAATPYHQTAEDMNEAHSTLIRIKAEGGPFSTSYKNYNQPVRASRQRLLTAARNLSMLCVPEGGMNYDWDLTYIIDGMTTVEHSIPVPVLYEDVLKLFAYSGTGNTPTHLVNYGGAFGEQIVWATQDVPNDPKLRRFTRHDILEGITESTARPLHSFQLFNTSASVAKMVDLGLKALIGAHGEPPLGLNYHAEMAFAHGAMTPYQVLQAATSWAAQVFGMFDSIGSISEAKLADLLIYPAGVDLLNGSITGTLQLQYVMRGGRLWKAETMEEVWPESGKVQEMPPLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXI4</accession>
    <name>A0A8H5LXI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXI4"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="479" mass="52038" checksum="4FAA4FE6F3E4ED91" modified="2022-01-19" version="1">MAAGSVGVGFEASSLSITKRDGHVTSPTMTSFEHRPQMRRKSSAQNLLSSFNPKQIQPPPPIAVSSSNNSAYSVPPVAQTPTATTPREWDAQSLHNEPLGTPGPVQHTNDEYLRDLIQKRILTLTYIRNIHEGRSHWFHTIYISRAELDKEFNNTDMKKRTSRFALLGMSLANLLDIQQPHDLLRGLLNTLIEYDQAREDGDKTRIYGMVSSSAFSNTRPNPRVAVQKLFRTKAGKKPGVLTEYSGTYGDASAESYLVNPHIPFPLDYHQTLLSLLDVLSEVYNKISKLLGPSPLPHSQHMMGPLGLIVPHPGVSYLFQDGTTSAHPSNYQTFGGSVGSPNPNNPSPGANLASTSTSTLQSTQHQTFGSSFSNLSETELSSSLWGIANANGAAGVSGSFVFNGTGASGGTSQGWSSAYADMVLKIDSKFKKITSTLLKELDQFARSGIKEELASLDPLLRNIKMSDLDGLSGGVRNYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXL3</accession>
    <name>A0A8H5LXL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxisomal dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXL3"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33651" checksum="B449378858C9031A" modified="2022-01-19" version="1">MSADLSQVVGYQLPDKPVSWNKRDLLTYAVGVGAKKDDLPFVYELDPSFAGLPTYPVVLSLKGDEQDVNLFANRMKGTALPGMPRLDPNRVVHGSQSIQILKTLPLVSGPGWKWKTRYTGVAENKSGLVLTAENTLVDSQGVEYAKLYSSSFNIGAKVTGQKFSKVIAGPPQAKPIPKDRKYDWSVQDRTTPEQAIIFRLSGDYNPLHIDPKIGQAAGFGGVILHGLSTFGFAARALLKAIANNDPTALQYFGVRFTSPVKPGDALETQIWKVGEDSAGTIEVAFITKNLSSGKIALGDGCAFIKKGPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZG0</accession>
    <name>A0A8H5LZG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZG0"/>
    <dbReference type="OrthoDB" id="3267487at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5375066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="639" mass="71151" checksum="1295AF4987DF6F11" modified="2022-01-19" version="1">MPISSPNHGHYPTPSPTLSTYTLTPIPTPCCQNQVVVQLQTAILIPDYSRYYKGPILSFRPSYIPLGDGSLVTPVFVADLEHSYALLFLFGFLAMLYTLNVFRAGSYLRRTRARYKLLFRMLFVSQLLAFAAIQPMMISYFTDSINCTFAVLFVLGAGVMSLTILMTGIYGVKVYKCLDNSTFALVSVVLFSLGVLAVAGLDLANTRGVRRLSGSCARSADEFYTKIYLILQFAQSLFICFCFLYAVWKSRNSPVARGRMSIRLSMDDLSVRQDHQDVNEIQPGHRARSWRDCEAATAREPQAVSSSPIPDPDPHPRPHSDKSRCAWFSFIRRWKSDDNHDVDSDSPERKLSFDGESAESSIPSISRPHGLPQPSPPYPRPRPHELQFGISDSFKERSQTRNQPCGLLSPSSSSFSQLSRYMPRMELFRNVMKDEVCYTATIALCNVLGATLSIVGINFTNSLPTIGWLSLSWLVVSVLTVHSFGRVIRRQEREYYIQQACSWQSGMVEHSRSRARTATASRHRTPYPRRVGIGVGDSSVDHGRDSQFEETRALTQSHVSWDSRWSMSDSISILNSPSRSISNAISSGSPTQSDSVRPVTGSTGQIVCIPSLTAQLPSSRRTTSVTQTFISDSELGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ATB5</accession>
    <name>A0A8H5ATB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_019083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000582">
        <property type="protein sequence ID" value="KAF5310503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ATB5"/>
    <dbReference type="OrthoDB" id="3268424at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5310503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="20033" checksum="3EBFB6D31FAD055B" modified="2022-01-19" version="1">MAPHPEPPVPQHLQTTDKKRKACFTCCVKKHNRFDDLPALKPPKAGELGDELDRYLSADVEAMDDVLGWWYGRKKDFPTLYRMGLDYLTIPATSTDVEHVFSRGRFLLPYVRNRLSADTTRALMCLRQWSLMGLIQDEDVMTVAKLPEIEVSDQNAEDIEMPEGYNDIVDVLSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AZJ9</accession>
    <name>A0A8H5AZJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_017917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000520">
        <property type="protein sequence ID" value="KAF5313803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AZJ9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5313803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27355" checksum="38948ED04EB76B98" modified="2022-01-19" version="1">MSPSATAQYDNSLVNLDIDVLIVGAGFSGVYGLIQLRKLGLNAKIFEAGKDFWRYLLSFPEIYKDWNFKEKFPTGRSSGITSTMSMRRPVSGRTSISNLTTSPISRVSIPSRAPCTTLLVGLRRGVDLRGKKVGVVGTGATGVQVIQEVAPDAEHLTVFQRTPNLALPMVQSKASPYLQKQYQDLYPTLFKKCRETFGGFTYDLIYDKKTLEATPEERRHHYEAIWAEGGFRFWIANYADMFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BAZ9</accession>
    <name>A0A8H5BAZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_018622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000433">
        <property type="protein sequence ID" value="KAF5319133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BAZ9"/>
    <dbReference type="OrthoDB" id="1715602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5319133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="14977" checksum="E9E700117199E49D" modified="2022-01-19" version="1">MDVEATKDVLGWWYEKRKKFPTLYRMALDYLTIPATSTDVERVFSRGRFLLPYVRNRLSADSTRALICLGQWSLMGLIHDEDVLAVAKLPEVEDPEQEAEDIDKQNIYSELSQDKYSSRLSLGIRYDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BHD4</accession>
    <name>A0A8H5BHD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000398">
        <property type="protein sequence ID" value="KAF5323166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BHD4"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5323166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="30544" checksum="706AA79AF5B419C6" modified="2022-01-19" version="1">MKKDGKANHEWVPILYLYEIVKSSAKRERDWGHLVFTDLTLTRFLIVMIFPAACDCGNYSHHDYGALTRYQADRFMSLLHYLKYEWSESKNKPNWSAVITHTMTMYEWSESENKPDWVRATYTTLDQAFKLNPELFDLAQGKPNLPPIFHVTADNFIPTLLDSELEKIDNVVAQGMRKKRAEPSTRDRVLIVNPKEGKPNVNSTVWKNKNPRQCSFCEKVSKDKDLQKCSRCKLMFYRGKECQRMAWPSHKFFCKSVTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTX2</accession>
    <name>A0A8H5BTX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000364">
        <property type="protein sequence ID" value="KAF5328297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTX2"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="43467" checksum="7BE7D26483DF32C7" modified="2022-01-19" version="1">MLHQQIMSTRSSRASAAKSPSKASPRKSRPSNKRKAKDEEIEVDLGDGAGDADGVDDDADAYDEEEGEHVEEKKRKAYDSDALDEDSDFEDANADAGRKRKRKVVKPPKKAARTPRKKRKVKKDEEDQENEDEDVVDLKDGQEIVGEVVQAPKTGRVPPGQISKNTFNFLSQLAKPECNDREWFKLHGRSRSSSSAITSIAHITSEPVYRLAEKEWKDFVDSFTEVLMEVNDHIPLLPAKDVAHRIDRDIRFSNDKIPYKRSFSASFSRSGRKGIFAVFRPGGQSLLAAGLWCPGKNELATIRSNLLRSSARLRRVISHPDFVKFFGEPKPDPKGDRQNIFGGEDELKVAPKGVDKGHNLNDLLTLHDDDDDNGEDEDDGGEDGEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVC8</accession>
    <name>A0A8H5BVC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000331">
        <property type="protein sequence ID" value="KAF5330272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2591260at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5330272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1434" mass="158679" checksum="BEECD641383FDC8A" modified="2022-01-19" version="1">MSLPTPPKTSHREKENRLPGSARSVVWSQQNQYHSLSSPPQFPATCSASRKPPARSILKKTSQPILPFIDVEQREVTPEPNNPLHDSSYLKTPVSQIISPDSKLSDLIAGYSVLTARLRPSVTEETDSSCPLLEPLKENRDAIYRSIDRDVRRALVDPMVNENQPKDCPVLLPSPTNSPRKKKCMTAEQAKYGRDLCTITQSVLRLLNLIFTLPAVYEIFTVTQLKNILTQVLAIPLADSLPTPNARKTCAISILVIQCQRLPEEVLAPASSRIAFSLLRGIDGELGKEGKRGSANDGLKAVHELSVYQPSTFIPVFVKLLPSILNNLLAPTVSLRVQACNALGGLVLGSINLPHSYEIHTRISSHIASFLTTVSPAKPSPSKTSPTKAVPNESPICRTLRTTLNAPDPIHVAQGPVWALSVLANCIVLLGSALYTDIRLSRIIHTLLALPMRHKKSSVRALACVVWRCVTWAYYQPQLPSDPEGESETEDSPQSSPSGSPKQGDSLRAALWKVVQSVVGMGSGVSTVAACVGSETGDDGLRRTFVVLGNMLSKNSEFKDAMLIISQLVSLETLPAGWHSVQLLPDKLFHTDGGLLLNDFESLQKTVRPILNQCPGINDVRPLTKEELTVEVLDEFFSLWKRAVSVGENIENHLDVIEETWTCLLKAGRAICEGELDRRKGNRYHLRDDRELRAEATPESSKSGSQRAVFDTSRPKQQSRWSPGKRLNMMRSLWAYAKNALDNDSLDMYAEKLLASLMKNEEEWTEVEGVARAQWAMFCAELSVSCEPDSLKAFWGYQVIVDAHPWVWTWTKEARSVVWSKFVKVWSSKCASWEGALVLLSVPFGEQHAWDMDGQELTVWDKLLALAIDKALDYGVDALCVVNQLVESIGGRCDTTFSSLTRVVEMMLMKVSLSDAQEVPESFVEFVTDTFRSSYPPEPRNYARMMWMIRSVVHFIESCPVHLVFNLMETMQEGLVLWIADEFRTMTEDDYALDVLPLYQAIMLGLQAVPQTEDIFEALSTLLEAIFCGRMDKPAAVLDTFNDFWEYASCGKLIPSTAWPPKVQEYFNVDNDDRPCLGEPFNDNISAQTEPIRAVSPLTVPSAPAPFMNIIAGFPSSTGPSPLLESPTILSTPKNRTRTKVSSPPRPNLSPDLARFALIRSPTTPSRRPSTSDSSSGHSPSKRRRVEKENESPVSVKVHSQPNSPSKKRRLSGHDDIEEKSPKKARLTHALVPITQATSGSPSNESDLVLQEDDVFMPDTKSISAAIKPNTSKSLFTPTPTRTPKKRKTMLMEAVEVPSFKQLLSREKREAVRTVKIYRAVRKQSETPETPGSPGSGSPCIPEMLDFGSDDSMMSINDSSPAGGRQLLSSDDDPHIGQVTPRHLTSPALRRGRSILDDDPPSDDSNEPASPSRDMVLRRLGRHQAINRNARALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYQ4</accession>
    <name>A0A8H5BYQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_014587</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYQ4"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="12">
        <location>
            <begin position="42"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="13">
        <location>
            <begin position="648"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5332027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="883" mass="97363" checksum="9EE5BEF48F6CAF0E" modified="2022-01-19" version="1">MSYMSPAYIPQTAFDSSWTALAGRYSLFLYREAGWESNQIHKGVPVLFIPGNAGSFKQVRSIASSAARQYFPRPYDASFEFKSRGAKPLDVFAVEFNEDLSAFHGPTLESQIAYTSRAIDFILSMYTPNTSIIIMGHSMGGVVATSLLPSEKISTVITMSTPHTLPPARFDQRIDKIYAHNREILAHDPTPIVSLCGGATDMMIPSESCILLPTNGRDAPFRRTVFSSALEGAWTGVGHREMVWCHQVRWRVARAALELSAAQSLSERSTILDRWLRDGHNLPPVSSDGTSIHDNYEALPAGMHIVLKQPTGSRSYLLPIPSTKSSTSHRFTLFVSKGSIPPVSPQNPNSLRVSVGICAKSPGSSADVLFECEALHPVTHKLIPNPVPGRVFPVPQEGSDESEGVVLFEVDVPVEASEKWIAVTIETARGEGWVVGGFSGDDVHVNDVRMAGMLFGNSFVGLTNPNALRTVVKFPKLLSNTLVVYRLTPQYTETSCKDALMPPLLMHTSHPSETHYFPLTFYHDHRVLLHTHGQAPYVPSTSNASNGLEFVIYSSGNSVCSSSLSGFHLSIDWLATLGRWPPRYFTTIACWAVAIVSVILFHLFDATENDHTALVPSPQQSLITFCRQSLPKLLFASYVIALIPFPPEYFIGTGGNFTLAALAPFLVLLATSLVCTSWLLLVAIMWPLAKITPIFIGRQREEILSARRSTLVSMCFIFVLVFFFIPWQVAYLCCWIIHLHNSASSGPLVAAEAAQTMPAEPVAIPLLRRDGDENEAHDANSQEMTSPRSTRQSPASHQKSSNVNQSMHLLLLMTWLLPLAAPVLVVWVRTLATAGLTTPFDGDHFFLNIAPFLVLVDFASWTNGPIFKKQRRVPHLMFERDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZN1</accession>
    <name>A0A8H5BZN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000328">
        <property type="protein sequence ID" value="KAF5331297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZN1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="16018" checksum="9A402FC616EB61AE" modified="2022-01-19" version="1">MYFFFCNTAAVAGTFTAVGLVSLVALILIITTTIRKRRAKAWDREIAEAAREAWATGTVEVPREYLDENDGGRYGGAGYAGGGYETGYGGGGGGGGGAGPGGVGGEAGSHGTYGVYEQSPMGGRGGEMYQMRDMGGGGVCGAKLFLGHINLTREGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C1F8</accession>
    <name>A0A8H5C1F8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000305">
        <property type="protein sequence ID" value="KAF5332393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C1F8"/>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="395"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5332393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="494" mass="56986" checksum="5CA34C0EA2E6C98F" modified="2022-01-19" version="1">MQVDITAKEARPYVESFCADTHAYTSEIPQRAYSWDAFRDAICEFIVSDDQAINTIENPKLRVVFLMLKKDLNDSDIPHRHKIRNWIMELWEEHLDNLMQEFEHALGKISFTSDMWTNSNMMPFLAVIVHWIEMKKTPKDRFELKTVCRAHRFSLGARKTQCLAMELWMLPEIMIQLWSTLNKSLIFEALPGQESNLKFAADYDPEVSFQRDLIANLWTIIRMLKKYWITGEEWDALEAYVQILQILHAFQEWLSGEKTPTLSFAVPSYEAMVTKWEKLKDALPQYATVIDAGIAKLHKYCDHVEASDTYTLAMTEAKQLFLHEVESYSAVVVGDGQQTTLSDLSNDDWADAILGLPTKDKQPTCCVSWAIEDEVNSYLSEALADPKKDEVAYWEVPLDILPIQASSVPCERVFSSLSDTNTKKHNRISPELNEALQMLKFTLWHGNPLSFTDRTSLEEELAVLKQLLAEQCNELEDKKVSIEKLLQMVNRVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C273</accession>
    <name>A0A8H5C273_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000282">
        <property type="protein sequence ID" value="KAF5333872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C273"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5333872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="27194" checksum="2D210CF58FDFEEF0" modified="2022-01-19" version="1">MKINIANPATGAQKLIDLDDEKRYRVFFDKKIAQEVPADSIGDEWKGYILRITGGNDKQGFPMKQGVLLPNRVRLLLSDGHSCYRPRRTGERKRKSIRGCIVGPDIAVLSVVIVKQGDEEIAGLTDVVLPKRLGPKRATKIRKFFNLSKEDDVRKYVVRREVTSSEKEGAKPYTKAPKIQRLVTPMRLQRRRHLRAVKRRKLEHQREQKSEYDALLAKRVAERKAKVAAIKASHHKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2L5</accession>
    <name>A0A8H5C2L5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000272">
        <property type="protein sequence ID" value="KAF5334050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2L5"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="24952" checksum="15A056B9B4ECB41E" modified="2022-01-19" version="1">MLRLTAIMADKVITFYDFPSKKDGVEGWNPFPARSKIQRHPLSKPSGFEYPDVELTLKAAGIPPTTQRPNGKPWYTLPAIVDPSTGVALADSFAIAEYLDKTYPDKPLLMPSHTKALQTAFNEAVLAHVRPIFPFVLVKFCGLVHPVSEEYFRRTRIVLFGKSVDEMVPQGENAKEEWKKLEEGFGKIAGWMKEDEFVMGDTVSFADFVVGGWLILSACLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C420</accession>
    <name>A0A8H5C420_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000250">
        <property type="protein sequence ID" value="KAF5334860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C420"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="374" mass="41466" checksum="7A3BACE99DF7EAFE" modified="2022-01-19" version="1">MKHLDIEAWVTVDEQPLDEFGVATHGMKASCWIASEVGMHFEVHFRSNRSVNVNGDFYIDGQLSDSGVVTEDEEGREYIASGLLTSLVSEKPFVFSEVRLTDDDGFSGRDLQELGEIKIVFEEVHIIKEDIPFDENVHCCKFSSEDLLHERSSKAITHRVGLGEERGRSKEDFMTFEAIRVIATFAFKYRPIEFLRANDVAPGSTSNGKKRQILLSDGIEKNVPTHQPQQSTSSSQEPQRKKLKSEASDQVTPPQAALMPARQTTSGPGPSQVANVASQLSGDAQAMPFEALIPSTGPVTKVSVATFGEKCQDDVDEEIISKLMRNGYKKMRTLRRLTIEKLQMMGFSHGEVDTLLDVVADFVEGFGKDGDDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7Q7</accession>
    <name>A0A8H5C7Q7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_014359</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7Q7"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5336249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="202" mass="22804" checksum="BFE0BA25F7168952" modified="2022-01-19" version="1">MSAFSSLPLFPTEVLARNHAILCTVGFLILLPLGTLLARYARTFTNRWFFGHAIIQLFLSGPVIFAGWHYGWKAADELELGHFEDPHTKMGLALLILYVIQLVWGLFIHFVKTPSPFGPGTRPPQNYFHAFLGLVILILAQEQVHYGLWTEWPTTTGNIHTVPQSAKHAWIALVVVFWVLYIAGLALVPRQFGQESRAREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9G4</accession>
    <name>A0A8H5C9G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000214">
        <property type="protein sequence ID" value="KAF5337579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9G4"/>
    <dbReference type="OrthoDB" id="2431447at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="318" mass="35273" checksum="580F53D49972D112" modified="2022-01-19" version="1">MSGNLDAFQDLCNMTLCNLRYLTVHPAYAIYKNNIPICVALINFMTDNSGTSAYTASISISGGNTGQPTSTPSSVKVKYLSTSNVSQKANFTWAGQTFGDHFASDERPMGEESIQTIQCDSTSNTVSPCFALIFLNDKALERVQMEKWRRREVTMKTMNTATIDQEVLATSNGHQAGDLVGWMGSMLRRSSGVWAGRGVKCMDMSMVVMGMISMQVFWASAPHLASPHSSKEKTCGLCWPTSKAWAVQRKYEDWSKVIWSDKCYAHMGDSQGWVFVTCHADEIFEEDCLIPSFKQSLTQVMVWGCMMKGRKVMGPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CC53</accession>
    <name>A0A8H5CC53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CC53"/>
    <dbReference type="OrthoDB" id="3067792at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="302" mass="34582" checksum="639D1B5C412C6E5B" modified="2022-01-19" version="1">MVLLVRTVLNESKLLYSRRRTILAQCRPLVFKQSFAHSRRVETPSRTVATLNPELIMDNDILDISHLKRLCFTYGSARIQDCEYDTMLRIAFPPGTRGYLYWHTHTHLPPYAGAIRFRICDKWTPSAFEAGHDLLQPNGLLPFELNLWQLALRPAFWSELIEDRVVSRESLEHCLKMLQQAKRKRGLYVICGFRHPFILNAGGSTTLWVAGKDTLERLIWTNLRGCNLPENNGKYHTFKAQFIRDKRDNVYMEVLDAPRALQPELKPGKLLAFEEAGSLLLQTKEWGQSLVSPDSLGSSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDU4</accession>
    <name>A0A8H5CDU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDU4"/>
    <dbReference type="OrthoDB" id="5967843at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="132"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5339921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="841" mass="94966" checksum="E4CCB4D54C833260" modified="2022-01-19" version="1">MDPGSSSEAWREAHSARQQQSRRRGPEEDWDLSRAGRQRMGSSNQRPATAFANSHHNSFSHSLINVVGGDQINTPAEDPEDGLKLLYQAIAHVGAFHDSETRYPPPKCHPKTRTAVLSDISAWIRGARARNRVHWLYGPAGAGKSAIAQTLAESFACTEQGNHLAASFFFSRSDLSRNNPRSLIMVISCCLADWCGNSQLRAAIDSAVKTRPAILGSNIEQQFQELVVKPFGVIPKESWETLPRVVIIDGLDECLGSDSQRRVLTTLFGGLVNQTPLRFLIASRPEPVIRDFFGQLPHRSITTRTELSDDYSTSRDIEVYLRDGFKAIVEESHSDVMAHIALPWPSIGVIDDLVQRASGQFIYASTVLKYVGDEYSLPAERLELVLGLPLGDPDALSELDVLYQQILSSNHNKARVIQILGTILVIEDIRSERWMELELPCWFAPHIDDQKVIDIVEQLLSLPTGAVTVSLRGMHSVLQIDYGIVKFRHKSFQDFLFDARRSGEYFINKALFHEQLARVCMKITNDSSPSLRSYVKYNCLKHIHLAKSTTDLVTKLRCFNFCDMIGCYLGDWFQPTPLYVSRSISIFQKFAKVLESHQIKTLSDSLQLGIYVAGTDRRESSKEFLSELELLFTFTMDCHYAPLNVLFPHNTVTPRSIDILPGLGCTTSFLSMKEIFLCVDPRLHSHSHCTASSSSNPVWHFIDFKRGRSRLAKHCLRTIRHNPSIKDRTHRGLPSNLECGYVYAQSRMSELLHHSPLDVELQHELKKTIPYLNGTKSCIRSFFGCNTFQMTRGTSQWKSQFSSVPNSLTPSTPELWEGLWRMIQGRQQSQQALARMGMIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEN1</accession>
    <name>A0A8H5CEN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEN1"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="269" mass="30153" checksum="FA78BEF6600B3260" modified="2022-01-19" version="1">MLRAAFASASQKHQLGPFLNTNLAIPAMTSSNTTLAAAAERDNFHFPIPDCLENDKPSEHADKVAASSKDKSLWTYFPHGPFKDGADFIERFWNTVFRGNPSQFFFVVFDKTKRQESQDGNGNFKLAAIMGYILTSEWDLWTEIGAVIVFPEFQRTHVASNAVGLLLHYALDLPEEGGLGLRRVQWRAMESNAGSIRLARRFGFQMEGVTRWARVLQPGEETVTNGRPERRGDPRPGLGGTDIAVLAMCWDDWENGGREKVDAEMNRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKK1</accession>
    <name>A0A8H5CKK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKK1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="59" mass="6364" checksum="6B77C9439B1FDD90" modified="2022-01-19" version="1">MSTTSAETTQEFGRDVGKTGGLEIVIWRFKLSWGLGMFSVPPSFTTLSSAFLSSRSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKR4</accession>
    <name>A0A8H5CKR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKR4"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="180" mass="20121" checksum="D28054BC6C637981" modified="2022-01-19" version="1">METSPSLNSPTSVRQSAHFVKVQVTVILVFTKYGLLYNEKSKQRRKAFPSEEAANRKGNADNDAAADLKKRVIPSSTSSRLKMLPILTRVTRKCLHDVEGDLLVLAAQQTNAQQKVNYSIDPLTALCLGAHIVDLTLILHNVFIDMLTRDPPRPLAVTRDDIDDTLQSLKPRMPAEFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKU5</accession>
    <name>A0A8H5CKU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKU5"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="19170" checksum="510C2EAC6AAC2905" modified="2022-01-19" version="1">MYYDPNNIGSVIKADVQLQDHAFSALRTLSINADSHQAVLPFLSCNTLTNLRKLRADKIAVETEDAFRSLILLIPSFAPNLVEFVSSYNPVTEIDDTLISDFSDKPISLDTFRALLPCHKIERFELKLPHHLLIDDSDVEKIASAWPNLKRIGLCPSPLGPRRRTKKPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPC4</accession>
    <name>A0A8H5CPC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000122">
        <property type="protein sequence ID" value="KAF5344581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPC4"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31321" checksum="160B020A0FAA6806" modified="2022-01-19" version="1">MALCRTRPELPVELIELVFDQLNEKALYFHEYFLERDWMACQRNLLSCALSCRAFRELALRALWYTMNTLMPLLRLLPNFRLIDGIYVLDGDFDEASLERFDFYATMVKDFRLKDLYETNQFNTKINDSVYFRLLRKRPQLLPSLTYFEYRDNEMVPCHMVSMLFISPLLKDVYLAVGYEIEDEIEDEDSDDESEDKSAEKKQGHGAAIFAYLSTKYPRRSSHAPAVDNGGGICKLLLSCRCTAEGSSLPQPVHRVIPKQSGLSAIHAAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPQ0</accession>
    <name>A0A8H5CPQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPQ0"/>
    <dbReference type="OrthoDB" id="2522283at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="521" mass="56205" checksum="6FCFE0F4E997F8D5" modified="2022-01-19" version="1">MGFFDYFDQEHLVSFDLAVVSKSSTLLPARLPPSAASRALPHLPLELVLLIFQHANDKYTYLSSSLVCRAWSLPAQQFLFNHVSLSSQSACLSFIDTISASPALASSVQTLSASIDHNQPFGLSQLSFAHAFAQCPNITDLRISLYGCAQRGTGKDIVGIPDVARMRRLAPSWDQETLELLRVGGQGQVKKLRFSNWSENRTSLNQLLEVFEELDELVIVGTSPEVPTSSSASGTPLPPSISLSSLRINIHSRTHPSPDYLSWLLHTSSTTSSLRSITFDRVPPAPVLDFVLNDEGISKGLEELRVCGLPPVAPATNAVVIAGNAAVASNAAVSTSNPKAVESILTTLSSLPRLKTLSIEQPASFLRVLLTKSLPPSIEHLAFGLEVEDPSLSDSSTSSRGHARSTSLAVPQGRPRAASHARSSSLSTLPKLGINQGPIAGGPVGMKTLVQTIRNELEDLKSLKVLLVDSDDDVTAGGVGVNDIRKSESKWLASLKMVCAQRGVEVEFERDVRRWRESFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPW3</accession>
    <name>A0A8H5CPW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPW3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="274" mass="30392" checksum="395A8B62B6C89379" modified="2022-01-19" version="1">MAPLTISSSMKLSTGQEMPFLGLGVYRSDDTYTACEAALKYGYRAIDTAQIYGNEKQVGDAVKASGIPRENIFVTSKVWYGAEKTTNSVQQSLKNLDLGYIDLYIIHSGSWGKDVRLKTWKALTEFAGPDKALRAIGVSNFGVKHLEELREAGLPTPTVNQIELHPFDQQKPIVDYCKQHGIAIQAFCPLVRGAFDDPTLQEVSKEYNKTPAQILVRWSIQRGFAPLPKSSHPDRIKSNADIYNFELSDSTMAKLDALDRGDAGAIDWNPIYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS71</accession>
    <name>A0A8H5CS71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS71"/>
    <dbReference type="OrthoDB" id="3256296at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="235"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="61986" checksum="E0779F4C26327B5A" modified="2022-01-19" version="1">MTCHDIFCCAGCTTAASISNVTCSEAHFPNKKNPADSVDWQKFGVSTFQHITELHQKHQALLWGLLETISWPESNIECKNRPVEVVISTTISKLVFSHSLYTHFRPLQEALFNITANVSFKKFRYDSHVGNTPSYPTSLKALLYLSERAAIICWEYRLDPGFWFFIVLDNVQNYIHQRPLCMLHQNWMNLGMAGTMWIKLFGAEVDSSSSSTGTMNSMSSHSSGYGFLVRQGLRQKVPDALSLCFPLPTTRGSETQLNEFLASSLDFFKSCSQTGDCFHRQILLVGGDGFTFELLWKLKEHHQLHKSPFHGLKIMSPVLAWWHTGWTNDTHLVDNHLVNYASLDPSTLSHSASKINRKLSKEQGKYNYHQALELMYLVADMRMLDCWRLLLMCVTKEQGLDVSDCKDVFNIVEVLWVASKVPNTPQFERYAYKLHDLYTTKEAIYRCAHGMEDSQIPTASPSSSASSPPQSSPSFMAATLSSSESSSPLPPSQTSMSSSRVLQVLDEVWTPPQPNPTPVGDNVLTRSKDFMWEALHSQEIVWSIAEGDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUQ9</accession>
    <name>A0A8H5CUQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Chromatin elongation factor SPT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUQ9"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5346972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="79" mass="9045" checksum="2581188EE6D9857C" modified="2022-01-19" version="1">MTALKDSADRVLSCTSAYFEGMIAGIDPENSWVQRWQRTSKYARGMYAIRVKGRVPEDVESELESRGIKYRPRDLSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZY7</accession>
    <name>A0A8H5CZY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZY7"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="18032" checksum="40CD6ECEBA7A8E23" modified="2022-01-19" version="1">MAFDLPQNLSKMSSNVLMTTVPVFSGVDFNIWADILLSWLQATGLSSVLGSDRPSDATVSSVSPLSAEDMAAQAEAITVALKKQADWDEKNDKAIGSIKLCLSPAIRQKTLGMTSAKEIWATLKNTYGKPGVSAVYTDFKRATSITIPNDANPSATIELIHMHFNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D399</accession>
    <name>A0A8H5D399_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sucrose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D399"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5352299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="82410" checksum="611D9FADB6D4071C" modified="2022-01-19" version="1">MTGGGFALLDQNDSSNAGHFSGHAFIRGPSLLHLPIITICLLGVQIFWSVEMSYASPYLLALGISKSHMAIVFIAGPLSGLVMQPLIGVMADSCTSRWGRRRPYMFSGTVLCSIAMLLLGWTKEVAGWFTSNPTTLTLWLAVLSIFLIDFSINAVMAVDRALVVDTLPASMQSAGTAWAARMGGVGAVVGFFVGNLNLPSLLPILGSSELQIISILASLILLGTQLVTAGMVNERVLLKGPSGPGGSSSKSFTQELKEIFTNLFNLPRTIRQICIIQFFAWISWFPILFYTTVYVGDLNRRAFYDPLKSQNTQNITRTFLTRAFHQFSSLVLRDTIDDIEEESTRLGSRALFYSSVLSLLVTIGVPFFVTEASSSSRRRKRERLHPRQARHVNGGVMGGGRGSAGSVDDYEMSPGSSRTPRGLGRFTSGNGLLGRLRELSIPESIKVHIASLWAASHAIVAVCMMGTFFTYSVAGATFLIIVTGFSWAVTSWAPFALLAEAILTEPADSMSGGAGDRSSILLTDTRTRLSTSHRRSTSGGPGHENGNRNIGGSGGAGVNVREDSQIFVPGHSSDSESDVESEDGESARKEGAERRKKFLTLGSTAGVSKVDLRPEIRMFGDDYGDGDGEGEGDEEADEEATLVGNRRTRDRDRDEEEGSVDEEEDLGANHNGGGLSAKAGIILGISNIFIVIPQFIVTGISSVIFAIFDPDKTVVHRKSRDVSEDEIPKFSNSVAYIFRLGGVSAFIAFILCWRLARELRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3S1</accession>
    <name>A0A8H5D3S1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3S1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="105" mass="11085" checksum="753674D00616F899" modified="2022-01-19" version="1">MPVSTSSFPTPTPVPSPPQPETSSAPPQNPLNSSSNLLCSALSSSTDILRSKAFTLSSEVKESNSLPVKITPFSLVTGIIGHIPTWPRTSTTIFGKEQTPKHSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4J7</accession>
    <name>A0A8H5D4J7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_007928</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4J7"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5352974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="701" mass="77645" checksum="0F50184B1F132D5F" modified="2022-01-19" version="1">MATAAQLAKERYLADRSAPLCGLEVAKAFNQLSSKEKFYTHHISEASWAGARIIQAQWTPQAIDLYDLLILIFSDKSKSKIANIDTLKGSLTEEEWSDLLQYTIQVLSNLVNYRSFGFTKIIPRVPKEKFEEVVGKSENANEAKELWNKLKEHIYATEPAKSLFIGKPSEGHVSNYYLGEVISDEEVASVQSASLPLACFSSLLNEINRVRKNGTDDFTLLVASADKGKPAVHDNLTVSESQKIKLTVEYGDCSDALTKVVASLKEATKYTASDIQTKMLKDYTESFATGSIPAHKSGSEAWVKDVGPVVESYIGFIETYVDPYGGRAEWEGFTAIVNKTLSAKYDKLVQSAPELIKVLPWGPNFEVDTFRKPDFTALEVVAFATGGIPAGINIPNYYDIRASTGFKNVSLANINAAKAPDETPTFVHPSDLPLFNKWDSAVWELQVANHELLGHGSGKLFKEDEQGKKNFDEGIINPLTGKPVSLWYKPGQTPDSVLGEVSSSMEECRAETVALFLCGNKDILEIFGYTSPSDISDIQYITFLFMARAGLRALEFWDPATKKHGQAHMQARMGITQFLIREGIASLEEVRGQGGELENLYVRIDRDAVLNKGQSVVGKLLIDLQVRKSTADGAGAREFYNKLTTPIGGWEGEIRDTVLRKKMPRKIFVQPNTFIVDGEVKLKEYPLTPAGAIESFIERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5M7</accession>
    <name>A0A8H5D5M7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5M7"/>
    <dbReference type="OrthoDB" id="3250324at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5353589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="62407" checksum="8E09B52D9B44BB06" modified="2022-01-19" version="1">MLMPQSQYNPHVQPQQQYIPSQAENQPTQTFQFQDMTNQVTRAANKRKAGGNSRNTRAAKTPRTTTTTITASAPAENATPTSTIESCSNLTPVETEPALDQPLQALSMPSARVTGVGPISHDSAAESMAFQKDTHFGSLVRTPKNTPNANAATDVWYFIRALKSAKQPDSLPRGVEVNWMTRPPRKEYSRVISSKLINYSAHTPWHNSDGQTKTLRTHLSEKHGQSWREIVLIKQLKGWEALANGLPQEDQSKPRPSFTLEGFYERLLRWIAVDDQSLNVVDCPELRDLLLFIGTDLADSDIPHRTKLSELIVQQFQKEYTEMINIKNSLGRLSWTSDIWSRTNLESYMAVTVHYIVRAESGHIELRSRLVAFRRIESSHTGANIAGIFMSVLKDLGAQNSIGMITLDNASNNGTFVKELSDALHDLGIDFDINGNRVRCFPHVINIAVKFGLKHLSASLPGRDVDPDLDSAPDWIPSSDAILQPNASEYYYALQDDVIAAARKVVNAIRASDGRREMLQDVIKELNEIRHKANQIPSLQLLRDVDTRWSCVVRLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5U4</accession>
    <name>A0A8H5D5U4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5U4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32684" checksum="807994F48125A1B9" modified="2022-01-19" version="1">MQQGTTTVNHTVKAILFDMDGTLIDSSPAVTAAWQLLKDTGYDFLDLPHILASAHGYRTVDALRKWCRINDEELLQKEVVRFENAILSNAQAKAGSGGGIIALPGVKQLLDDIEGPNKAEQGEGWAVCTSSTHYYASRALPAAGLRIPQVFVTAESVSQGKPAPDPYLLGAERKNVSPLDCVVVEDAPTGIRSGKASGAVVLATCTSHTREALEKENPDFLVTDLSHVKATRNPDGTVTLAISQPEDRRQDVAPSPEDTPLTTPVISRMPSAVDLKKLQSGLATPREPGTEIDDYGARGIKAMSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6N6</accession>
    <name>A0A8H5D6N6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6N6"/>
    <dbReference type="OrthoDB" id="2575973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034239003" description="DUF6987 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="49"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="195" mass="20579" checksum="A08A14BA1AB2DC14" modified="2022-01-19" version="1">MIFFKVICLLSIFSIAASKPISTSQARSNDVTLVENRRAELNITVGSVLNTLQDQVNTILPQIQNLDNANAKTLSPLIDDLTEALDNAADDLSRIHASGKVDDKAKRQSNDNTANLIATIVRDITLTLDNVVVTANELPVVGPLFNGVDKSLNRVLFGVGSLVQGVLKLVANLVLNVAGILGSLGLGLTLGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8G9</accession>
    <name>A0A8H5D8G9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8G9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="74"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="9">
        <location>
            <begin position="469"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="599"/>
            <end position="600"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5355491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="621" mass="68730" checksum="C3B162884C8B33B6" modified="2022-01-19" version="1">MVGLAQSTSLYTDPKDVPTKEYDFRNVIATRLSEDPTKSVLVIEAGLDDTNVLPIHVPFLINQGSIVDWNFTTVPQKELNNRTIPVPRGFVLGGSSSINLWDHYAKVTGDSGWRWDALKKYWDKASTYLDSAVISTLVPPTSNPAIPPPPRNDPTLSNGNGPVLVTRPNFPTELDDKVTSASTLLQQKNSRFKTTVDMNTGDSIGFGRYKQAQDHEGYNQETTGHGERSSSATAYLHPALNSKRRNLDVLIQTRVMRLLQSRNTALNSTTSNDHSSVPHFNQVEVAQSVDGRLFKFSARNEIILSSGAIVHCRFGGKLSQGTPQLLLLSGVGPKDELKSWELMLSRIDPPLNSKFSRSGKNLRDHPMLVTIYNVNSNQTFDDLMRNPALKEQLLEQWQNNRTGLFANTLSSVHGFMRLPEDRLKGVQDPASGPHAPHLEMFFADGFLPLFERLPANGHFITVRNVIVAPKSVGSLTLASANGGTFTHPLINYNIYADSFDIQAMLQAINDTETFLSTAPWTQDDFIISVAGRNSTSIGTKEEKIAFMRKNTITVFHPIGTARMGRKEEDVTDSRLLVRGLKGVRVVDASVFPTIPECHPQAVVYTLAERAADIIKEDHGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8N4</accession>
    <name>A0A8H5D8N4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8N4"/>
    <dbReference type="OrthoDB" id="3193844at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="453" mass="51105" checksum="0C328CD6D7B1EBEA" modified="2022-01-19" version="1">MNKALSFHTIMTTVLPISPVDESTLDDSAPLVSLSSPPAITTASRSELPIRDTVHYWESVVLMVGEGQFQVPRYHLEKHSPYFRSLLASRGEQTTESCGDAAPVRLDERVTASEFETFLDMLYPSYVPVVELTRSQEEWMAILKISTIMQFFRIRQLAIQALTSMNIDSFTRIKLARDYCIPQWLRTGYAQLVKQLSTLTVDEVESLGYLTAIRIFRVREQMAKIPFWSGSSGNILFSTSHWDDGKVRDAIEEEFIGEMVEADKQSTVYDTMRSLGEESNTFEPANEVHEKLTVAQKFADTTNTSEPANEVHKNLTVAQKFAEAIRLAREINMVKGMDMREREKEGILNNLRRSGDKYWGGYIPSEHSFALDVSPLSTHKAADAVEERMLYLLNPLAQHSGDEGGKALEVTIPKKFKGGPVKNAVGRMLATRNLTSTDHYLNPRIMIISLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EV84</accession>
    <name>A0A8H5EV84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000523">
        <property type="protein sequence ID" value="KAF5313556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EV84"/>
    <dbReference type="OrthoDB" id="2800877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5313556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39694" checksum="0C6F25C4B97B9859" modified="2022-01-19" version="1">MSLCSVAIVTRGRWPGPESDMLKHFKSDWKLTDSYIGMCSLPASGKVECFEDEKPRPSITSLTAHLRKDHTDNLKLAATAASYAADPEVPKELSGASASARLLDGYIKEGVLNPTVEPMRRGFLKVFTAWLIEDDLPFTTGESPALQRVFDYLKIKWKLPSDTTVRKVLDEINEELWGNVIKELMAVSSKISYSHDVWTNRQMIFSFAGIMAYWIDDDWKIVERLIDFKHLDEKEHIGQYGVKEFYHSANNWIRCLAHVVNLVVQAILKAVDEAGCNSDEEDYYLLNKEAPFHYKESEDDELIAMEEEENVEVDEEHQDSDVSELPENARNLSAVKRASVLQLLSALPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4U3</accession>
    <name>A0A8H5F4U3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000393">
        <property type="protein sequence ID" value="KAF5323637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4U3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="31562" checksum="C04D27DEA471BA8F" modified="2022-01-19" version="1">MLDVLAALHSNRSVVFSAHDEQFICGHDQLSLEELTLSLSQGCNGLGNIMDIICLSSFGSLAAQKRFTKVSVDLTLWIGWTNFGLHFYKTIQGMLEQSSVTDLYTATPYGVIDDVYWSNGLDSGTGFEQATYPSELPPVFSAARDLACRAAIEFSKQIEEVYLISRLAQTKIMGGQLKKWIQLVVEVTGRGVMLTSVGIQTLESSASAQDPRHVLTLNYDPGYHHPSVHSDSHHVPQSGSATAENSAPSLAVRSVGVPRGAGIGSSISPYDPSFSDYTYASLGSNFDTNFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8Z7</accession>
    <name>A0A8H5F8Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000367">
        <property type="protein sequence ID" value="KAF5328139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F8Z7"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5328139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="161" mass="17515" checksum="D569DF65D98A592A" modified="2022-01-19" version="1">MEGNWKTSSFFTTIPRRLVALVCGFVPSSSHPLDHQVLGLHRCDASTMPKVPSTSTSSKSSSKATKDKPAGEKKQKRPPSAYNLYIKNNSAKWKEENPGKKQSEMMKEMAVLWKDADENPNKGREPKPKKKKSDSARATVAKDAASSSPPPSSPGLASSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF88</accession>
    <name>A0A8H5FF88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000256">
        <property type="protein sequence ID" value="KAF5334586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF88"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="230" mass="25514" checksum="779B9FA2A0B9C2EF" modified="2022-01-19" version="1">MTFREFNSLRLPTLSRPTPLCLIVNGTSAAIVQCFMLNRYWVLTSRKSVVGAIGLTILLHVGSAAYVTALIIAFHNDPSRTRILTGVILWLTSGAVVDISIAILLVVYYISTDVELRSSRRLIRRLTTLALKTGLFTAVTAILPLALFVSDYQTNVDLIFIYNINHVYSLTLLYNLNIRRKLIGIGQTINLGSEVVTPNFRSGVDTRGRSSTSEARAASELRHQPDTINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FII1</accession>
    <name>A0A8H5FII1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000212">
        <property type="protein sequence ID" value="KAF5337663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FII1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="392" mass="42343" checksum="6A104AB201FA4E6D" modified="2022-01-19" version="1">MVSSFLLWGLPKLLHFCRVPNESRSLLALVGSLSNGILYLSSPILLPVMNTFPQMKTRVMILGYVICVAGLIGAAYARTAGELIVTQGVLYAVGGSLLYFPMMSYMFEWFHVKLGLANGILFSGASAGGVIAPFVIEAILDRWGRKVTLLSLAITLIIFIVPCFPFLRPRLPVKNVDHRRSWSNSGYFRFLYIRTFWILISATVFQSLGNFIPFLFLPSFASELGLSTTSGTLAVSLVNGASAPGMIFLGWLSDKYDLRIAMVISSLGSSLSVFLLWGMSGTLAVYIIFACVYGFLGPGWGALFPRFVSATIDHDPERSSSLLAIFLAVRGTGNILAAPLSGGLIRDWALTGRTGLGYGVGGYGPLIIFTGATLLASCFGIIYRMSCISRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FK30</accession>
    <name>A0A8H5FK30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_013176</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FK30"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5340090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="808" mass="94201" checksum="004ED70954A641CD" modified="2022-01-19" version="1">MIEVPDKARLDPTRAVKPHSKFFHFLHLFSTLMSHHATPDHRDLTPKDSTDHLQVPENRDGFFGYTEEKTLQHIEGKYLSQRRGSDAASEGSASFVGSLQMSTLQSVFGDSSHHRPASPFLEDTEDEGEIRKERIPTIPEITINPELLHLFQSLQKCLKLRDKYMCKSRQRLGDNPRDYDGNFPGFDDEHADLPGMRPYTDIATNHAPPQPEKWRIYPKPPPPHWHWTDKKHAMTADGRHSPVGEFNFDECEIPGEDAWEFAIDDTGVYQIYDNSEHQKPIFDIPTVREYFQDLDYVLGVIADGPMKSFAFRRLRYLSSKFQMYSLMNEVQEMAEVKRVPHRDFYNVRKVDTHVHHSSSMNQKHLLRFIKSKMKRSPQDIVIFRDGHELTLEQVFQSLKLTAYDLSIDTLDMHAQQDSFHRFDKFNLKYNPIGESRLREIFLKTDNYIEGRYLAELTSELMTDLEQSKYQNCEWRLSIYGRSLDEWDKLAKWVVNNKLFSHNVRWLIQVPRLYEVYKANGSVKTFEDIVTNLFKPLFEVTKNPKSHPELHVFLQRVVGFDSVDDESRVERRIYKKYPYPRLWDTDKSPPYSYWVYYTYANMASLNQWRQKRGFNTFVFRPHSGEAGDTDHLTSAFLTGHSISHGILLRKVPALQYLFYLKQIGIAMSPLSNNALFLSYERNPFPEFFKTGLNISLSTDDPLQFHFTKEPLLEEYSVVAHIYKMPQSSLAELARNSVIQSGFEMEMKQHWLGHQWYLPGAAGNDIHKTNVPNMRLAYRHQTLLEELDLISGRIDGISRVADSVAAGAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKN8</accession>
    <name>A0A8H5FKN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000178">
        <property type="protein sequence ID" value="KAF5340137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKN8"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16173" checksum="D1BC17F2A26B1966" modified="2022-01-19" version="1">MSSVVSVRSTAPTSTGTSSGSAAIAMATARRHLHLRLVPSVEGGSSSLSSSSSCPAAATTTPWRDQSWEWKERRWAVREFEPGNNQYNHKHVPVRLHHLKSFFSGVRYSASNFQTPSWVALYNIDDTTTFSHELYTGTRLCTNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLC9</accession>
    <name>A0A8H5FLC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLC9"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5341470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="552" mass="61393" checksum="FACC597D4554033C" modified="2022-01-19" version="1">MAGLTIPSATFSSTVKSFTLDEVTKHNKENDLWVVINSNVYDLSRFAQLHPGGKSVLLNQSIVTSFYRCVQYLISLVLPPEPQSLRFTAGQDATTVFYSLHRQEVLERPQYTRLIVGKIQDVEEQVTPRIPGSLSSVPYAEPTWLSKEFTSPYYTDNHRLFQRKMREFVDTVLREEALKCEEKGTRISQEVLDKMAETNLLAMRLGPGLHLHGRILLGSVVKPDQFDYFHELILDMEQARLGTRGFIDGMLSGMVIGLPPVFNHGSPELKARIVPEIMEGRKFIALAITEAFAGSDVNGLQTTAVRNGDFWIVNGTKKWITNGTFADYFTVGCQTEEGLTVMLIERTEGVETRPIKTAYSSTAGTAYVTFDNVPVPLGNTLGKVGQGLSVILSNFNHERWTIIAMCTSAQRVIVEECMKWTSQRIVAGKPLSSQPVVRAKLGDMISKVEACQNWLESITDQMNHMSHRDVADKLAGRIALLKQFASKAGREIAEDAAQIFGGRALTPSGMGRLIENYHRTSGYDAILGGTEDVLKDLGVRQALKKMPSNVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQT8</accession>
    <name>A0A8H5FQT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_008474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQT8"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5345298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36706" checksum="DA0DAAE52F31031F" modified="2022-01-19" version="1">MSSNVSKSRDKQSLHYIIYSGIAGGFAGCVAKTVVAPLDRVKILFQASNPDFQKYAGSWSGAFRAGHEIFNSQGVRGLFQGHSMTLLRVFPYAAIKFMAYDQILMPTREQETNFRRFAAGSISGTLSVFFTYPLEVIRVRMAFHTRTTGQHNNHLALYQTLHQMYHERALEPQSIATSSKSGAVPVASKQFLNQFPILKFYRGFTATIIGMIPYAGVSFLSWGYLRARFIPEGDKNSKATPLADLTIGAVSGAVAQTASYPFEVIRRRMQVGGITRPDRWLRWGETISSIWKASGWRGFYVGLTIGYLKVVPMTAVSFAVWQGGKRILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRP8</accession>
    <name>A0A8H5FRP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRP8"/>
    <dbReference type="OrthoDB" id="3161836at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5346679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="18971" checksum="CB7F80B7C39009A4" modified="2022-01-19" version="1">MSLRAVSAGEDVILAAGMVVMVLKNGMTEYKGTRKMISRIIFLTANTGFWTAAVAFTEVVLIGAYRGGLQFTVMEMPLCNIYVNAFLANLNARRYVRGECYTEWQSSPSRIIGPRPVGTRNSFENSRPSGEHLESTVAHPMVKIETLKTTDYSDSMTKYPKPDSFEGGVQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSC7</accession>
    <name>A0A8H5FSC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSC7"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="159"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="535" mass="60810" checksum="CC16A3EB852D7839" modified="2022-01-19" version="1">MDQNISTIAEPRATEQIDQISDNPSRLSCHLDACADASSSSSYPLPHRLQWAVERLKQLSTELEPDQLVVVLPKIRKLVERANQTNGLDLSEFDEFRQLLGRLVTIKERRSKIPVVRYLPCSSDLPPSEVNGPASPEWLAMFVHSDLPSVCIEDHNACCNICLEDFEEPPLALELQVDGGDDVDLMIGGDGTQARPKPLRQLQCRHVLHEECLPMFRGDYNSTFECPACRTKVWTPLSEPFSLLSAEIPRYAARNSVSNQQQSYDDYYDSLSLPPWQKIPQDLLNWAAGLCTSELDEALYSTTRGRRINELAMNIWANQTYKRYVHSRMTDNHAGIVDCFFVDLEMARMISNSISSGEYRRAGRILRESWDIFGLQGAPRLLVVFAKHISEYRDRWVVHKFSLPDGGLTAYHFSPKLRTLRAGRPAELWWNVFHLAWPDAAICSISRMPKPKLVPVRPSMQLPVDDSVAAVGVWRNILTGLPVKHDLDLEHLRDLIHTEVNSLCQRYNSWVSYLLTILGDLSSRYERVEGDGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT19</accession>
    <name>A0A8H5FT19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MBOAT-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT19"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5348640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="68423" checksum="28B28CFE0B6B514A" modified="2022-01-19" version="1">MNDSLSLPQPVSSTPTPTRQHFIEDRIPFVKQPMRLVDLTIEIPSNARSTSLPSESSRKPSRWGTLEFRFYLVVLCLALPVMIWIPTTLSNPSHRSWPKYHSLLDEGWLFGRSIDNSDSQYRSFRNNIPILAVVATLFLTLKFAWNRLYALTNSDVLHKDHLHLIPFNLFFSIIFLFGLHGASVVKVIAILLVNYSIAKACGSSKVGPALTWIFNIGILFLNDRYNGYRFGSLLPSLEMLDAIEGFYPRWYINFNITMLRLISFNMDYYWACRKVGSSEPGTTTLHQKQRQTVSHPEEMYTCINYLSYALYSPLYIAGPIISFNDFLWQFRRPLSITRSSVARYFVRFLFSLLTMEFILHFMYVVAIKDMKAWIGYTPAEISMIGFWNLIIVWLKLLLPWRFFRLWALLDGIDPPENMVRCMANNYSTFGFWRSWHRSYNLWVIRYIYVPLGGIKNVLVNTVLVFTFVALWHDLTFKLLAWGWLVSLFVVPEMLARFFLPPSRYSSEPWYRHVCALGAVFNILLMMTANLVGFVIGTDGIKFFVGQLFGTMEGYRFMIVVISCLFVGVQLMFEYREEEMRNGIYRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTN6</accession>
    <name>A0A8H5FTN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTN6"/>
    <dbReference type="OrthoDB" id="3219582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="887" mass="97414" checksum="3A891E2848C98364" modified="2022-01-19" version="1">MGSLCLSSAPILRCESFTRIENIVLIIPTGLEIIFSTSLIFTNWGTGWKHLLLTAEGWTYLALALLDLLTHIVPAVRDDLSLFKTLDIVLASLSFAPIFFYTLFLLLLMRGELVDILPQRYRNVAIIMLLIFIPIIVALEEVSSFVGITHRIARQNDGLSFLAIGFSKNGDRTLWTFFTSLTLALLTAYQAVNFSFAFFRVGKAFIDQRSIEASSSDEAHLFMGIGWIAGGYKLGAIETVIGFAQNGGFGVALTRRILRFLSRAFLAIGIAKGVDMIVDFREIKDELTANKRNRFSRRISRRIISNPRHSTFRQLSPTAEEFHAAPAPPQLPGAPPSLQPRQPRQPGGLLGMSEFAQVKNDAIFRRGERVAVEFDATSGRPPTLHMRFSVLSIPDAAIAAEFAHLKSEIKSAPNDVPRPSSFYANSTMTRLTEEPSSVVGTVGYSSNRNGNGNKDVVAEPEPARIHNAFATMPVSQHGHTRHASQMSGYADSVNSLTHSVVNRLAAQFPGLPPRVTNMTQYRQTLYEQELERVREKEEEEEAELARNSSGKSRKSGTSGLSTSNSFKRKPAPRASAYLDDLAMVSGGVNAANPTAAAPSTVNPIPIDPFDDTEDLPLSFPTPGLLANPDNAKSPHRRTLTGDSHSTTPFSSAAGTDYNFARPTTPGSYAQSSSFTTPNSENPFKYDELQQVQDNSRRTPFLRRQTNRHSRLGSKNLSVGQSELTAVREDQDYVPGDDIESQRNSAYHSRGKSMETIDISWLRRPDQEDASPGSSAYEEAIFQQAVRGKISTPSSVKTPSSLIASRSTPELSRIKSVGNAPRRYTPAPIRTNYTRGSIYIEPIVIPPRGEAFAEVELLQGSAISSMRGGPLRDSDVLGPDDRAYIQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWS5</accession>
    <name>A0A8H5FWS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_009399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWS5"/>
    <dbReference type="OrthoDB" id="3026831at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="505"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="588"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="505"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="588"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5352061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="721" mass="81643" checksum="146E1F928295B378" modified="2022-01-19" version="1">MSFTDDKAYPSSSIGSFNHLSSANFSQNRINTVGRDLHETHHHNYYQIIEDSKGWRIKTMGSGILKIGQTVIQGITGLLYGSGSSPSIETTTQESIETLEELFNGTDYRVHSARHKGRSVLVKVFHGPRAKEHQKAAISFNERLLHPSMLRMMACSPSSSQAPFIIFDDECERGSVDYCVASALTDGLPRSVMLGFQLIGGLSAGLDYLSTVIDVPLSTVGRDNYEVYITNGNQVKIGLGCYKTGRHGEDGSEADWVLFNDLCSKLFNDANRLLYKEDIDRNEASIAEDTEADEEPNPQFQPSPFVSHSSSDFPDSLSSSTMITPRRELQWTRSPQVSTLASVSRRYRDHLRMSPYHGALDLRRLNAKRRFEVISHRCQGYRKEEITFTSEIKECAVVLHTMPFRGEICLDMRREIVTEGVFRCICANLMMDRQLRLDVPIAMRGSIGRVLSIFPHQHIIIRVFPVNRLIQSLNLPRNPLSDLPNSLLLPGSSTSPTGSRDNKLPIRRKLNVAQAAKEAGAEYTSLSAEEKEPYKRRSQQMKEAREREHTAYMRTLTPEDIKRENAFRAAQRKAGKSRKPNIKDPNAPKKPLSAYFMFLQRIRSDPYLVKQVFGEETETTKQSVLAAARWRSMTDEERKPFLAQAEQKRWSMKLHVAYMKKAPQVMEPVSASVFYPEAVLSPTTSLSRPGQRARVTRVIICLRRRFLFRSFSFYATPLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYW2</accession>
    <name>A0A8H5FYW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYW2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="30239" checksum="136C4E26ADEE1B72" modified="2022-01-19" version="1">MKPEKPIKSYRQGYSTAIKTRKIEMMLMEKYNISEGIDMKAMYKRYITLPGAGRLGGWIFERHALLQTSLTYKERSRGLLKDTFPMEIMLNQKNLVFSVPNKAEAISFGPGGDLPHPLQHRTLTFIDKMKDVRFDDDADIDINEGYFVPTDVGNPLFDAVFFQLNSEPPVMWVVQVSTDATGKPPGSRQDYPVLEETKERAQEWVDKGGYLVDKPVQIRFMFVVPQKTQKRLQDIRFKLPDPGDTEKEKWSGVKVYVQFVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0L4</accession>
    <name>A0A8H5G0L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0L4"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="33"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="316" mass="35332" checksum="B315AE9D3319CBDE" modified="2022-01-19" version="1">MSSSASGSLPYTESWLEGPQATKFYTRLYNPSSPKALVVFIHGFAEHVGRYNHIHPRFAERGIALFTLDQRGFGRTALDEKNRSKGSSWGKTSWTDQMQDIDWAINHARKQVPDVPMFLMGHSMGGGEVLGFITDSSEKYSTTVKLLTGVIVTSPLITQAHPASKLLRWIGSKASQLTPNTLIPTDLKPEHLSRDPAFNEAYMKDPYIRLTGSLRGIRDMLTMGEELLSVRWQKWPSHLPVIFLHGTADEITSHESSKTFHDKIQTQDKKFVSFPDAYHELQNEPNGVKEQMVDEVGGFVDAHLSSPSSESVSAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G177</accession>
    <name>A0A8H5G177_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G177"/>
    <dbReference type="OrthoDB" id="3069796at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="414" mass="46848" checksum="A0C2E5D5D16940A3" modified="2022-01-19" version="1">MLILNSLWEIARFCRTVLQRNVAAEWVKYLEITSSPGSLSGNQPFSSFYGLAAQALPKLCNLLFLRLAGPPEYATALRDCHFSRLRRFKTTLPFSKALLLFLNRHPDLSDLGLEIQLYQFYLQQSLTLAQLQSLESLKPLSHLQYYRGRSEFVPYLVQEQMPLRVVHLELGSESLNTVDDTLSALESFGSPTLEVLTCYLSCGWSLDLLENISNKLPHIELLTYCNLRGSNAKESQLEELAQNTSHQHLEVYNAFTVCAPRFSRLKSCFLVQPGPFDYSHMNKVLLNKEFKSIVSWGTLCPSLYSIKVPNGIQWMRDQTHSHLWIPGGEALSCAPQILHWFAGILSREPESVTAWRSLLRSCAVDPEQLPSSISMENLRKTLFEMEIRPALESSDGEFASSTVIEAPADSEGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1G1</accession>
    <name>A0A8H5G1G1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1G1"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55276" checksum="7020C9B64BAADE44" modified="2022-01-19" version="1">MTATTTAHSSFSHLFHSNYAASDDEVPLIRNLISTSSDALDRLNSLIERLQAALRKLEQERDSLQDYVSAHSGLLSPKRLPALPAEILSAIFTHCLPDDRNTTCNHSEAPLLLGRICKNWRDVSLSTPQLWASIHIVIPKLRGNPSVLCPLIHPRINGIEAWLSRSGTLPLSISVYAALLNSQVRGQGQGHSESGLDHIRELLDILFQRSNRWRTIKLAFDNACMSILEEYWPWGAHRELPCLQTFHLSRPDGPARGQPEQSAAKWFLHAPHLRRLSLRHLGIEDLLEGHFPWSQLTQLGLEVPSSSYIPVSAAIRVLSQCRNLYSLSMSYVESRTEDPALPTEAFTITLPFLRNLSIKSAISLSDSYDVQNLFCYLDTPVLQCLRLDVDDYVDDRGIFGFLDLGFKLVLIGLGHAAGLIETRAYESVCLVQHTTTLGYTAQIVSHIVMRLLLFIFSSSSSVVSLHLSRKVLGDESQIAAMDATLEADVERFLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5L5</accession>
    <name>A0A8H5G5L5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5L5"/>
    <dbReference type="OrthoDB" id="2972176at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5358814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="20326" checksum="B501C2CC502E2528" modified="2022-01-19" version="1">MTHFEMASTSSLHPSLPSTSSYNSACLGSYPSPVLYPDSDSDSTDETWLDPVALEAIISTAPASHLRAVMVKLAASNQPFQHAIARELEATSRHHKSESGQSKLTNVVHCANCGQSYRQSAPTTCVFHPGHLEEEVFDFMSMSPTGLRLTFSKTISMWSCCEDDAESRGCVVAPGHATSVHHSSCVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5Q2</accession>
    <name>A0A8H5G5Q2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5Q2"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034089166" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="11726" checksum="10888CE4F04391E6" modified="2022-01-19" version="1">MFLKSLTALALASLAAARITLQVPTNPVVGAVTDITWSSDSASDPQSFTLFLLNANDLPFGLRANFGEVQTSAGKATVTIPNTVPEGPAVLRAVNSTAVDFVFATSPQFDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Q5</accession>
    <name>A0A8H5G7Q5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_013999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3259294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="195"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5359899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1953" mass="223018" checksum="B0F4AD88C06032DB" modified="2022-01-19" version="1">MKVYDVLPPPPEDLDEVLAIMFTGPCKPTEKDYKRTPMLVRRKQVFEALTWLRLNHPAYEDVKISMDNLNKYPEDTPPVTVAFKEMQSEGNRIPEATSIHDNELEIGTELGSVPFVVHGITGEQLQNTSVELQKAKALAYLKSQGKFLAVGHSEKSSTMFNNPLLYPSIFPWLFPYGMGSIGMTTLKSFSEKSHKKYFMNYHDQRFQSDPLFSFVAFSHEQVKKTTSNGFALTQKESFSAIADRILNLNPHVLNTLIDKLSKGGIVRPETEEEKLCYEVIQDLDHVGGTVKGSMSSKKFLRTELWSLISYLGAPSWYITFAPSDLTHPLCLYYAISDETFDLNLNLPNDERTRKIINNPVAGAKFFDFMVQMFIKHILGVDTDHDGVFGKTSGYFGTIEQQGRLTLHLHMLLWIANSLSPQQIRDAILKNENDFQRRIVEYLGSVHCGDFMTGTQEEVEQNLQTASGNEDYVNPLYSLPQCPPIECLCTSTENCEPCQAWTAKYQQEVDDILSRTHIHKCKSTLTKQGTRKVGKDYLGCLDNKFGTCKARFPRETFPTTQVDTETGALRMKKTEAWINTYNQTVTYLLRCNSDVSSLLSGTAIKAVVLYVTEYITKWNLNTHVIFEVIRTILQRNAEMLTGTLPRHEKARKIITQIVNLLTVKMELGAPMIALYLLDKPDHYTSHEFKSFYWKDFVSEARRFWQEPDQLQVENKNHEKVVVIQHNGKLVGFSSVFDYIYCPEALSEMTLYEWVCQCERVKLAANKRDVNDPDDEISERYDSSSEDSSFSDEEDTYRPQNTLKKSLANKPLTKNVLPKKGHPFVHEHPLASTHYLRIHDKRNIVPNFIGPSLPRRNKGDREYYCSVMLTFFKPWRTGKDLKEKKETWDSAFLDYQFSAQQKFLMDNFELRFECLDSRDDYHAQRKAQSLGIDPSKLEPDFDDGIHFDPFKCSDDSLGVRERRRQLDMQEMTDLLANTGWTNAKCDLKSHIPASFDYPSMSPAAWRLEIAKMKSNVITNKLKENKDQQYNFPNKYPDQVEVLDQHMLEEKLRSNQTQKLIDDLCLEFSLNLEQEQAFRIVANHAVSSISDQLKMYIGGMAGTGKSQVLKTLREFFKRRLQSQRMIVVAPTGTAAALLQGSTYHSVFGINSSEEGEFWKMSASQICSRLSGVDYVFLDEVSMLSCKDMYKISAKIASALNRPLLPFGGMNMIFAGDFAQLPPAMGGENVSLYSHTIGTSSSDQHASIGKYLWHQINTVVLLRKNCRQTGSSIRDVKFRQALENMRYKQCTAEDITLLRSLISDPSNESRSIDNPRFRNTSIILTYNKHKDIANELGTKRFAAETGQMLAHFFSEDKEVVFDELPSKTHDRKRKRRKATKHKINDEVQQQLWKQSPSTNNMQIPATLSLCKGLPVMIRFNGATELCITKGQEGTVHGWQAGKGRHGQLVLKVLYVKLEKPSTDVQFKDLPLNVVPITPNTRRINCKLPDDRIIQISRTQVEVLPNFAMTDFASQGKTRDPNVVDIYNSRDFQAIYTALSRSSSADGTIILQGFNVNHITGGVKDKGGYRQELRELEILNDITKLRENRKLPPSIIGDLRGSLIQQYRSHFGKSHTPDELHESLVWDTNEKFESTLHKDISWKILEKENTPPVKKTLGNFVPIEHPSLHSSPTPSEETIHPTSHNSDRLIVTCDYPTLKWSANSCAYDSALMLLYHLFRTERAAFLAESDNFSSILMNELSATFQSNSSNYADIRDQIRRELSILDPDAFPAGAYADTSDVLHELMRSVSPTTKRTVVCYNSHFSLRERTQHNLLLTRSTGSYQSTQDCVSHFVEPWADQCPSCHSDMLRKYTFQRFPKFFLMSIPYECDMEIQNIIHVPQGAESRQYHINGIIYFGNDHFITRMFDGANEWVYDGIGTGIPTKLSPDFQAHSNALEFFAHKKAVVVLYVCSENENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7V3</accession>
    <name>A0A8H5G7V3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5359989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7V3"/>
    <dbReference type="OrthoDB" id="3249214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5359989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="518" mass="58520" checksum="8220F674B417695F" modified="2022-01-19" version="1">MDKVPYNGFPPASSLDLRKELFQSLQALPMSLSTWTTWDSKNRLLKLPLEILDEILSELDSHADLMALALCSHMCANLVLPKHAEYRVIRVRHRRPDMWAHLARRADLARNIREVYICQKEDQAATDHFPTTLLPAASKMTAVEVLQSHLANGREDRRVLNICTALGHMTKLTTFTWDCYELCSCLSSSMNVLQEGMILHALSKLPLLKRVSLSGNFNTFGTYMSKPLSPMVCDIRNLEYLALFGDVWSTPTTAEPLKTLLRLSPQLKGLEIPIEAAAISVCVFPHLEKLKLFLQSGTSSTINQKWNNFLQNHPTLVELSCVPSLGISLPSSGLPKLKSLRTDSAMLDSIAQAPNPPVLESVYGILDAYNINFLSAPAFRYLKKLEVSAIFQESDLERITNTCGQTLAWLSIAAGPKFELDVWLKFLATLPALEVFRGPALWMAVDDDMDKMHNAIMQLVTVCPRLEQLEHKSIYTKRRKFKRIAIIREEDEEGLHVRYEVRKPPPRSMFDPMDGTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8L4</accession>
    <name>A0A8H5G8L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_009166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="159"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="540"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="832"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5360296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1410" mass="156791" checksum="09B83E5FC3C5CCB6" modified="2022-01-19" version="1">MKFSNPFHPPPAPPAFGNGKVLPEYNASFLSRLVFQWIGPFLDVGYSRPLEKDDLWELPDDRQTAQLADMLETNFFTRCPPEQRPWHLREKLRRPNESIEDTSLTSVDEKDNVVPKETELPDETTDEKSGKRAKQKKPKSPYDSSLPKALFVTFRTRWLLSGALKLCADTLKTTTPLVNKVLLTWLTESYIYSRLTDEQRASGILSRPQGIGYGIGIGVAIFAMQEVASLMTNHYMQITLTNGLAIRTALIGNIFRKSLRLSGRSKAEHSVGKITTMISTDATRLDMFSSNVHNVWIAPIQIIIGIALLISQLGYSALVGLGVIILGFPIQIFLVRIFFKARRKGVKITDSRVRLTTEVLQGVRLIKAYAWEDFYTMQISNIRTKELKTIKRIIVARSFALGLVTFIPVLAAVLSFITYSLTGHNLNVAVIFTSLQFLNIIRMPMIQLPVVLTSMSDALVALGRIKSFLAAEELEEPYKIDYDQKVALNVDGDFAWETARKVEESKFSRGADAGKGGEGGHGKKAAGRGGRGSTSNALPVSRPNTAETLPKKEEKPFELKGLNLSIPRGSFVAIVGRVGSGKSSILQALIGEMRKTRGEVVFGGSVAYVPQTPWIRNASLKSNVLFGQDEKEDRFNQVIRACSLERDLEILPQREFTEIGEKGINLSGGQKARVSLARAAYSDSEIILLDDPLSAVDSYVGKEILDNCLLSGPLADRTRILVTHALHVLDKTDYIYVVEGGEIKERGTFQELMEHSKLFSRLMEEYGSLEQEKEKEMKEGKPGEFKVSDDKKEKEKKAAALMQEEERNTGAVSWSTYKKYLQYAGGVTWGPFIIFILTLAQVSQVGNTLFLGFWTGMTIPGFRQGQYMAVYAGLGVSQAFFTSILIFFIGYVNLNGSFKLFRTAFNRVLRSPVSFFDTTPMGRIQSRLSKDQDTLDTILSMTLGQLLTQMSSVLGTIGLVFYVFPYLGIIFVPLSLGYFLVQAYYRRTSIETKRLDSLMRSALYSSYSETLTGLSTIRAYQEQTRAVSDAQNGLDMENRAYYMTISIQRWLSIRLDLFGNILIFGIALFAAGFRTSANPSNIGVVLTYTLSITQLFSDMVSMIAQNEQNLNAVERILVYSELPSEGEATTSNDPPPAWPANGEVRFSNAQLTYRPGLPLVLKDVSFHINAGEKVGVVGRTGAGKSSLVQALLRMAELQEGKIEIDGVNTRNIGLDTLRSRLALVPQDSVLFLGTLRENLDPTGMRTDAELISLLQRAWLLPKEGSVDPVIEAKFSLDSTVGDEGSNYSAGEKQLLALCRALVKNSRIIILDEATSSVDVETDAKIQSTIQTEFAESTLICIAHRLNTIAYYDRIIVMDAGRVAEFDTVLNLYDKEDSIFRSLCNEANLQRPDILRIRASHGEIVKNTEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA68</accession>
    <name>A0A8H5GA68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA68"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="446" mass="47169" checksum="49D7A3AE86B59750" modified="2022-01-19" version="1">MIPMSARNESATTDDRISKADADALFPNSLPTSFISSVLALPAPTVQANSLNPFPGQGFPVPTPSTRPDDGQPRHPIGQSQGQSDGEGDDDGHPPPVSITTSPRPLVTTESLSATPSQATSTITTGTAVSSDGVPEIPQSSASPSFEPLATGSVVTVITTTTSPSSSSVSSVNSSLSATSTAVSGADTGSSRNSFFSNKAAVIGTFTTAGIILLLLIAVCAFRLSHRRRLRREEKSLDMENDKIIADFAEKTLLDAQNNKPNAGSNLMDGEGARQRTRINLDDPNPNIFVTRTVTKKEIPVTQDGRNGGWTEKSKPPPESLGYGYGYGYGYNNAKTMDAPDYGNHFNTGPGPVVENQNHPNYGLTSLGSGPTSGIPYPSSSNAQGKSPYQHAKFPNPYEHTHPITHTATSWNQSSVSLSQEPMKVPDTYAYGGISHEYEGLSTRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDK1</accession>
    <name>A0A8H5GDK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDK1"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="370"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="638" mass="71687" checksum="FCA75E3DCDE8027A" modified="2022-01-19" version="1">MIRLSAEETILVAQLIAGVTFKNKFGRKKDSISTEDALNLFQGAKLPDEVLLYIFSIANKEEGGYLDREDLGVVVRLIGWAQIGVQVSWAWVHRCGPTAVIGGLPVLRQPNDGHGRLTTDCIYREDDAVLYPPFSAQLRGKFLKLFLKHKPVGDVLNAQHVWSVFLLSKLPSSTLADIWDLADIEDSGDLTLTEFLIAMYFVDGLMHQKFAALPTNVPSHIYEQAVHPVPDEPEAGPSVPRLYRNDRQRWAIRSALRSLHKDADGRITKKVFMNHLYEQYFVEEDGLRIWDLVDVLQEGTISQDEYTVALFFMHRVLVGIELPESLPAILIPPSTYTHPRFQTSSSFNTLDDGWEPKSGRPADWHICESLKSNAARIFSVLDFEGRDYVKQEPVIMFMKESKLASEKLTQIWSFMGLAKKRHIRLPLFTVILFFIHWCLAGQELPEVLPETLEAAAASSSPSNPNRHTIKIEPSMLSSVQDCRNSLRELTTENQRLRQQRQSLTNHSTSICPSIFTTPARTARPSPRPISVPLSELDAPFQSDSLEASVSSADLEESANPIAELRTEVEQLRATIQSLMVENATLRNSVSEIQLQATGRGGDRGQSAQRLDNSLTNLNVVDVEDLLPPPPYEEWISDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH23</accession>
    <name>A0A8H5GH23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH23"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="527"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="753"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5364924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="788" mass="81579" checksum="B07574B230A16D68" modified="2022-01-19" version="1">MPVICQTIITGRGKRPALPSPPTQGLLTAGLNSSPQLASQRRSSSLSSSSPGSISLPSPQLQIASPQPLLSPGILSSVTRSDNPFLPSSVTQRIIGNAEARIQLGQGQANQEQSWNPNTFESVGRSALMKMNEMSRRVEAISNNDSNGSGSGSSSGDYFSGRLTPGFGFGGPSGAGSRSGTSLGGGERPPSRLWTAATNAGLINPDGSFVNPLPGSSSSNTNSNGGGSMSGQGRGMDGFSAPMGPVKITSTQEALAKIEELQRMRPASAGFLSNAAARLVNAFETFGSMGMGNSSERARDAGAVKTEDMGDQPSSVPPPRPRSQLGINVSELLADPWNMTMALPTVPSLPPTYDPDTEVGPSSSVDKESASTNSGAQASSSSSSSSSLFPDFTTNHQGLQVYTVGHLMPRSAIDDMSGTWSLNTNMIGESFASGSGTGDGLNVGSQETRADGSGPSGLYDGSPNAASSPSSSGPGLASGSGAGPSSSGPGSPMVVQSSAPGTSSESGSQKLRVRRSTFVPGWAVSPRVLLVEDDAVSRKLSSKFLQVFGCKIDVAVDGVGAVNKMNLEKYDLVLMDIVMPKLDGVSATSMIRKFDHMTPIISMTSNSKPDEIMTYYSSGMNDILPKPFTKQGLLDMLEKHLMHLKVIQQMARIPRSVGIPPLSDAGFEQALTSHAALITNGNNNNDDGSSSSALTPFGQSLALRPNDDLDDNNGRINPLAGMGLTDEQYNMILAGIVNGDTFAGSMSMGMGFGGDQSFDGSGSSGKRGLDDGGEEGRDPKRSRFEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH48</accession>
    <name>A0A8H5GH48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH48"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="182" mass="19911" checksum="94DBAE56DDE3991C" modified="2022-01-19" version="1">MYGCSRRILIFLIGFALVMIGVASFLIFSHNYSATPLMTKEGCHAPLDATVSLHELNRRSLQVASAWEALFVYDVILLGFTLFKARQNACDGTQMLGSIGGRVSLMQVLVSDGTLYFVVVDLSNAVNIVSFYASLSPSNCSILTQLFIPDYFTSFQGRSSNICKLHLSLHDVKTNAKLAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHN9</accession>
    <name>A0A8H5GHN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHN9"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="462" mass="53318" checksum="7E8772DB2510EEB9" modified="2022-01-19" version="1">MDYFTNCSQFSVGTLTINSLGGDQNNYHNPAAQHGPSRKAEDVVYTKFIAKEDLRVVAELRSERKFDVYSARHEGRIAVVKQFHGPRAKEYLKRALKFNHRVMNPHFLYLKGISHPLSETHFIVFDDACNANFEFRVASALQEDQTRSVRLGLSIVAGLSAGLGYLFQIGLPLNPLLEEVLEVYITDDDELKIGFEPAGLGIYEQAEDVEKVEDLLWNLFNRLCRKTFNRANRFLYQDESFQDQRSAIILELEPPYPDSDTHRDTSEVSSAPSNPRRELVWKVSRRRLSTVALVAQQYQNNLNRLRILGPLSLTLRYFETRLGERSNFRHRCPGYRKEEIKLTANIKEVAIINHSPPSNSEICLVCGEAVNEEDELAGEVPAPNASKKEQIEWRRRQNTLAVRRSRKRKLERQQMLKNRIDELENRMDEVMVEAEWNNVLLQVVEQILRSHAPFLFDAEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHT1</accession>
    <name>A0A8H5GHT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHT1"/>
    <dbReference type="OrthoDB" id="3066004at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="391" mass="43529" checksum="AE402DCAB7C22DEC" modified="2022-01-19" version="1">MTRSLQCYSSRHRLPAPRVNNPEQIIRSQSGSRNQSRRGSPRPQQYAPPVPDLHCAYQAHVYNFDDYIDHFWDIEHREFYWCNKTAYPCPNCYNSIPLPPEANPNPWGQHINRGQEPLINGHQECTAPLPPNPLIFPPPGQPREATPQPSTSSEPQPSSSSVPEAPEQPLKGDPTPPPSNPPSCHSPDPDPHPNPPSSPSPPSNPDPDPSEPNDTVDSDSDSDDNMSKATKAFNKVTKLEKDGSNWSTWVTRVQRAAGSIGYDKYLTTAPTSVAEEQQQDKDLLNGIISTLPDTIFRHYKNKSTLKELWDAFKQDYDAKDPLTEASLEKRLFSLTCTNPAKVGKHLNNLITIMDELALIPNSNWPSSPLLPICIKPLSKPSSLFTEKNQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIU6</accession>
    <name>A0A8H5GIU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIU6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034520359" evidence="2">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="24552" checksum="F3E36D71CD2EE0C7" modified="2022-01-19" version="1">MKTPAFFATVLLSVVVASTAMPLPMPDGGSLQVVKGDERQPPSVSGLLPPGDAPHQSPPTKRADEDKPAHAGEDGPAPPPPSDSAHHQPPPSKRADGDKLAHAGPPPPPPPSGSVPHQSPSKRADKDKPAHAGEDRPAPPLPSGSAPHQSPPSKRADEDKAAHAGPPPPPPSGSARHQPPSKRTDGDKPAHTGPSPPPPSGSMSHQPPPSKRADEDGPAHIGSVHPPPPPAGKPSGGDAQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJS4</accession>
    <name>A0A8H5GJS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJS4"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="78" mass="8331" checksum="C59740E6A15544E7" modified="2022-01-19" version="1">MSYVIFGRAIKNEHIVLGVVSTLAAGILATSGGKKDVPTTVQQVKESIPIKAGSSEEEQFIRKFIAEHEKEGASAGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK86</accession>
    <name>A0A8H5GK86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK86"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="464" mass="52771" checksum="0ED955AAAE2A9B83" modified="2022-01-19" version="1">MPGHIINTQKALVSLKILVVGGNICGLAAAYTLQKAGHSVIVLEQGDGKERSSGGLRSPPNMTRVLTRWGLQPYLSKYAERCTQFSFMQGETGEQIGLMKLHEEFLKDLLADFMFIQHGDLLSILLDLCLREGVQLRYNSKVIKIATSPASVTLESGETLSGDLVVGADGQRSLAREVVLGKVLKEEPTDQLCLTFSIPTDLMRNDEDLQHLTELSDWSIWLGDSYLFHGSLVSGQRRYSILLSFSVDEDLSEYLENWTNHYPVDHFNLDYDRFEPRVVKLLQMAKYVTPTSHMRRPLIKSVVDDLDKVVLVGEAAHPLMPQGVHPTAMCLEDAEVLGTLFSRVNSTEDIPRLLAGYEEIRLSRLHASVDWEYRKRRMLTLPKGVEQQMRDDKIRWGTEYEHWDHMNEVSFREIWGDEVDFYVYDATEKAEDWYIKWGRLMSQPNRASITIPPTPTVEVSISAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLY4</accession>
    <name>A0A8H5GLY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7alpha-cephem-methoxylase P8 chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLY4"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31733" checksum="D9BD28DA925E142C" modified="2022-01-19" version="1">MVQATQTVSAKLHFFSPPSDGSRPYAYINSTPGKPNTSWKPEERLVEIENVRGNESSVSLDTAGFQYYNEPTKHKSFRNDQEIEKEYYPESAELIKKLTGASRVVLFDHTVRRRTGETDSGPDKRQPVPRVHVDQTTESARARVRRHLPESESAELLKHRFQIINLWRPISHPAYDWPLALCDFRSVDKEKDLAPVTLIYPDREGETLGVKYNPGYRFKYLKGMTPDELVLIKCYDSKEDGSVSVFTPHTAFEDPSTPPDALPRESIELRALVFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMD0</accession>
    <name>A0A8H5GMD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_003636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMD0"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="562"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5367406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1095" mass="126013" checksum="19C830508B7254ED" modified="2022-01-19" version="1">MALDDCSPVLSILKQYFPMVKSLRQHLQDILEPGQKSFGWLQGQADKSPLTSPWRICIIARSQEMLIFTPKRKKANNIITHGYGEAFRNGDTPLTRRGIVNYFVNTIVTALQGPQWELLLQRIGTTAMIHLLTETNIFISLPNNSLCQMTGEPLNLKKAPTNSLVNSETRSSRKRRMLDGDENERPFKRPKMQAVVKTSAGSTKLTVRSPIDAAFPRQRLFYAKPAFVPHTNRILVGLPSKHILNRQRPSYEVQGQKPDICFEDTRLHSQQARHLSKYVFPSQYGLQSPFSYHHYATPDFSDREDEITRHGVCKTPKRLRETLPLLEKLLWKHGKCKYKLLRDRACPSKLAENHTLLDSSVILQLISENSSEPLLQTQQPVGEISLDSAGNSILGHFSTQTKNKPRFAEFCFHVNEVYRYVVLVTNAVIPKRFWGSEANFKLICKHIKLFISCRRFETLTLHTVLQGFSTSACEWLMPPGDGNKQHRVNASDQLKRRELLEDFIYWFFDSFVLALLRTTFYVTESSAFRNQVLYFRMDDWQTLCAPLVNKLTLETFQKIPESDTEELLRQRKLGFSFVRLLPKETGVRPIVNLKRKQSSKTGDASGGPAINQILQAALQILNYEKERQPHLLGASVFGPSDVYAGLKKLKANLPRSNGKLPKLYFVKVDVQACFDTIEQTKLLEILRQLISEDNYMIQKYGQMSTGFDKTHRRFARRAVPEGMALVLRAVLLLTGSLSDEHPDFIQYAKDLAGCIRNTIFIDQVIYPVSKKQEILDLLEMHVTENIVKIGKDYYRQTVGIPQGSVLSTILCCFFYGDMEKRFKHFIDDPQSLLLRHTDDYLYVTTNRLKASGFLHTMMEGHPEYGCFISRQKTLVNFQYDQNIEIVEHDANAVDLAFPWCGYLIDVHDLSVSGDYTRYHGFHLSDTLTIARGRNLGSAFRHKMLRQAKTRSHIIYTDNRLNSKHVVHSNIYQNFLLSAMKMYVYVRDWGLSTKSNERFILGITKQMICCCVVTVRNSGSSKLARDHKGQVSVQQQDITWLATHAFHTIFSRTPHRYTLFLRHMATELSRPRHWRRAERFRKVVKDSSNALAHIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ79</accession>
    <name>A0A8H5GQ79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1437"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1462"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1655" mass="180768" checksum="C1CA8A2B2F0A1E7F" modified="2022-01-19" version="1">MNSHSSLDAFAVPPSNVAPDLLDDDPFAASTPAKSSSPLDFPASRLAPSPTRTHAHRMASFPRLTPARAKPAFRPRPSLPSLRTLSHEDVHFTLPKKPRKGRVGAQLPFEPWDLHPEAQTPPSSEGSGQDFFLAGPSRCGASFLSDLESRSPVRTNFEESDIDYYQFTPFSDLPSLDESEEDAEDASDSYMTRNSSESEDGNHRRLSSSSSSESNYGYDPHSWDLQRSYSHGSESTWSTLGPLSPLFTENENDTVHARSSSEDYISYNHNPLQSTTVFLDGRDRDTAIRANFRNRHSNPYWSPSESELPYQRPKDDSESESLYSSSSQSSCSASSDTAAENQQTLAALGLPFRNSRNIPNRQNLLGDMSDSPASAVAPSCHVASLWIDDEELAGVPLFDDPERDLYIIGAALSQTHVSQSPPELSLLTVTSETGTFTSLTGTLPVDSPIDITSDPVSPSLSSSPTSPSIAISNTDLDSCPSSSSSTTAAASNCSAIPTTGTQDFNSQACVTKSTSTSQDPFFSATTNTTSTTSVLATSSIPFTTSISTPTSTSRPTSITPTPTPSTSTSSSTPIPTLPVDMPTPTLLEPNYGMSGSGGSSVGTVRTLRARKESATSSSTTTLIGTPSPSQKKFIPTALEDWEQEALGLAGDSNSGYQSRYSFGDRDRRRPSMTNTQMQTMMMSTTTRERVYPSSPMSGASGGNGRSGAMVDSGYGSGSGRERAKSNGSYEYGNGNGNGRGRNESGAPNSNGHGHGRGSGHRREEDDEDEDGYRRNMSRRLAFSSDEVSATSEEESEDDYGSASPAVQGLPQTRRPSHSHLRSQAHLQQSQSRRSQSQSRSQSQSRPQSRTHTHSRSPSSDEDEDDDVPLAQSIPTALRAQQSIRAKDREAREKKRKERAKEKQAKNDALARQAEMLHTLPPGAAAAMPAVMSSAQEAAASAMQGKGASRRAHTHQHQHVSGMDAPSIPNHSQNQKEYALFDNPTSTAVPVKTVRQMRSFHNEPRRMEDLNTLVPTTPLPAPVADAPVQRSATFSRQRSKSVSRGDVQGQRGRAMTLTADAPPLPNSIPIPVPKRSMDERSPMSVGKRSLDQSVAVTGQSQTPPGSRPPVPPPSELIARQKEANAKHALVQQRVFIGDRQRFVVVEINPNTNAGEVIKMVEAQGGLKEWRGTGGWMLFEIAQDFGMERPIRSFERLSDIEASWNKDKLVNVFLIKLTPFAPLLSRSALPSASPTYSGYIEWEAKRGKWVKRYMVLREHSLWLSKRDNGKDEVMLCSLSNFDVYRVTRLLKAPKEYTFALKSTDNLSFFEDTADYLHMFSCRLDKGEAWMEKILLARERHVLSQSAAAAPGATGATGLQRNTTRKGAQKPLLNLNNPVFEPGCIIITIIYICIAVHIDLFTEINHIKYTRNWRNKMKMYMEGYYNSNESEGGQKAKIELQLICGFLLLLGRLVLLSSSLLGLRLGTWLVLIDIHRVIVLLSFGFRLRLRLRLGFILVNVHSITLLLGFRLRRSLLWFLLSIAIIRITLSRSPLASEAVSAPPSEESSSLGEPSSVEDAWKSSEGKGRAVSKSLMFLLVNRREGILWTAFGDDFEIKGTCGSGTHASSDSGKDDLVDVGEFDEGGLFGDEEDVFFEHEEVALGGFEVGFDAWVSVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQH9</accession>
    <name>A0A8H5GQH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQH9"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17306" checksum="1D5D173400BC194D" modified="2022-01-19" version="1">MADVTDPALAAEMKKKRTFRTFSYRGVELDKLLDMSNEDFVDLVHARARRRFQRGLKRRPMGLIKKLRKAKKEAPPNEKPAVVKTHLRDMIIVPEMIGSVVGIYNGKVFNSVEIKPEMTGHYLGEFSCSYRPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR74</accession>
    <name>A0A8H5GR74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR74"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="9990" checksum="12388A6FA39368FF" modified="2022-01-19" version="1">MGRSAKVHKRVPKKNKTTSPTTSSVQPAQTQQLQAAKKKATLKEKSAAKLASSTRKEGEYVLGDVDYVSLMMGGRRKAKQEAEKLASQSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRE7</accession>
    <name>A0A8H5GRE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRE7"/>
    <dbReference type="OrthoDB" id="3268221at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="858" mass="94421" checksum="941AF9CFA19769B3" modified="2022-01-19" version="1">MSSHYQQTEYPQALEDDPASSPSSSSQDWPPSIIVDHPTGNKTDLNDSYFSLPYTRRPQLKSRRSKSDLAQRSSRMKHDGSSSRSRHASSSASTQALLIITNEQLKQRIATLENEQTRAVNMFAELVQERNSLLKELAEASTKIKMYEVQYEAARREIRNANQIIQRLEEQRAEAEQDATKQRKKVRTLITEKLVKEGWDEGYREGIEEGYSSVVQRSDHGGDGGPWNPRIFSRLRRSRKTERKSSADDSDEDGQSSSTPGGTGSRRGSNPRQRLDSRSSSRHISPPVRPPSAPPSTGRAYSLARSITPRPPLPHHSSEPFPTNVSSPESIHPIIAPQPSQTQVFDVPHNPLPDPAINVFDANPSPHIPANDGHDFPGSSEPPPVVAKGATMDRRHEEVRGRTLESAKDRKPRSRMTSRASTRISEYDLVSPPRGSSIRSSNVQREVPQRNFVPGASERSDPMYDTSKQMVEEWRNVVDPDQGPHQDNPRSPTVQSPPQNSPPLRSKTPNQGQHLITPFVSFANRMSTIPHAATSSLQSPRVSGGPRQPREPVRSMTSPPGFEMSNAGPSTSQAMDASRRQSRSAASPPHRKHDRVDTFNRGPVDQPVASTSRQPPSSSTSPPVYDPPSGTARGKTPISWLRKQFQRSYSNPAIPHDINIEIEPPSQSPSDSNPTTTVLNPILLSPEHANKPIPLPNDIIATATRGVEVLGPSSTPVPNSITITLPDEELPLGFVPMAPLIPTGDINNGRFPPMRSPTPRDRERERHQSQPRRVQSPEIFSPVPNNPVLSDPFTMSPIPRPGTAPSVVTGIASNGHMRSDKSTSPRSRALSFGFGLGRWGGTSPDPARPISIFSESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT60</accession>
    <name>A0A8H5GT60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT60"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13260" checksum="1C61B3CF4DE02150" modified="2022-01-19" version="1">MLSLLGSIQPDPFSPFHRPATPSRGKSTDVSEVDKMYVAEELMAELSAEGDVESDNSDNDQDGFEVLGKHAGKATAAVARRKAEEEKKTAEKKAEKKKKKKRKAEEPSGAEKVGKKKKSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTJ8</accession>
    <name>A0A8H5GTJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTJ8"/>
    <dbReference type="OrthoDB" id="2548929at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="908" mass="100070" checksum="75F4511333815BD8" modified="2022-01-19" version="1">MSISFGGLGLVSLRRPFAELVGMFLGKGDAQSLFCLVVFCIVFLVLAYLTNPSENSFRAYLTELSFRQHLSRLDDNADDDSDVQENQDGKSSSFRHGASGTPHTLPFDNRSPFHFANRASVSLRTPKHVFHSFGIFTIAAIVPVAKGERPLLDRDSLMISDSWFIGAFGKWWRGGVLEAWYQDVIARSDDEGNWSSGILGMKTLDRLNDLHALPGLPFSTRNLPPNGLSRGSPPRLRNREKSSQRTITQSSRSTTPPPLPKSVSLPLHTPRNTTAPSDRVAPQTLTRTQSQPIQSDQHNPAPTHTASFDQSPRVVELLQKISSSNAAVLDLRAQLTDYQSSASQSHGVLQQELSSFRDKKRQEDSARNDLKSRTKALDESKRLAESAKRDADKKLRTAETVRDTATQRMEYLDKEISLLRQCILDDESSLTRSKESMSEAEQEVNQALEDKRREMKAAEDVIAYLSTRARELEEKLSDRKEKLGIIQERIESQKRGKSLAAHTSSKSDPWTPTQNHFITPQSAALSSMTASDQDGSEVLSICDRRSSDPRDRQSSARPTNLMLGSLSNFSGQSVLTNSRPNLLANGFLDQFSSQPPPVITNFAPFADIDGLPQTPAVVISPSTGSSLIPTGLISSMDNLDNLSRSFRSESDVLLDRDWREKSTHGFSSEAERADNHIAADFVQTSSPAELDTDRDPFEVRVLSQRGRERYTHNHGPKLQQSISDPSPAHHIDEVDPVVTEKTAPRRWFTMPSKDKSKKGLNPDAQVFDMFRKPQVQKTAASNTTVSITAPVYDALNPNGLGSLMSSNTSDSSTLLRAFAPSPAEREVLQRVLGGSTNASLERLPSLSDVGSIPPSPNHTHSGAVGAVGHTSSRDVGKVLPAWFQSLPRLGKSNFSPWDDEEPVSNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTM3</accession>
    <name>A0A8H5GTM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_001938</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTM3"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="281"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="555"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="148"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5370620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="647" mass="72642" checksum="1D3F146E6B111466" modified="2022-01-19" version="1">MKYLYPAGHAIDQLSPSLLSLKIARHSPCSVCPSCSGLHPAPGVQVVPDNASNESFLDDLGHYGSDEEEPPTYLEHCACSHSVNEHGANEHEIGTEEFRRRSLVAIRLDELLEDVGKLADFEYTDVDIANLRQRMKLPVSIVAPSHNLSPQQRFKSPLLSSPTSSILSDVPPPNKRRRISFSSLSGDDDDDDEDTPLAARLADSTAAQKAPGKRTAGPAAARLPTNTLPNGRSNGIPEPRVKIEEKLDESQVARLATGVPVDSAEIKTEKAAAVELRKGIIRVTAVENDRQPRSLVILTGLKTLFQKQLPKMPREYIARLVYDSSSKALAIIKRGYKVVGGICFRPFAHRGFAEIVFFATASVDQVKGYGGMLMDHFKAHIRKAYPGMNHFLTYADNYAVGYFEKQGFSKEINLDRSIWAGYIKDYEGGTIMQCTMLPKVDYLDKASITTRQQEAILTKIRQMSRSHIVHRGLPQFQEGAPKDITVEPKDVPGLKESGWSPSMAEKQIKATRSVPVYWRTEDENQPLFPGSGILMRTTRKSPDRLFMERLLRELKNHHQAWPFQLPVNGEEVPDYHTVIEKPMDFLTMEHKLDNNQYSTLDQFITDARLVFDNCRLYNQEGSIYHKCANSVEKFLNDQLKEREKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTS2</accession>
    <name>A0A8H5GTS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_002119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTS2"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="292"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5370802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="644" mass="71788" checksum="E23B72603F705CBA" modified="2022-01-19" version="1">MNESSHLSSLASSPTMLSQPIPATSDLNFFSSSKSKNFPSSSTTTTTTRIIRRQPHPSPASVPSRSSSVSSSPLSSPPSSPPQSSPTKKRKSPAQPSRPAKKPRAEKREPRKRVSPRSSARPSTALPSPEPLYRSSRSRSTSLFPTGSSSPTPARYWATSENGDPGDDHSSSAKVVEGLMKNYKAYFKNPEDPDDTSFEPHPQKYPWVVLEYPNTGASEKFILLAPKDKDHYSPILDLEKTLYTIAECKSACLFAPTPLSDDHFSAVFLDDDQRAELGPIPSESLLEAASPPLSPSPSPPHSRSSTCSSDSLSSLTSISDAESPPPRINYLRAVQRAIHRQDGPLFVNSIKKINELFRKWKGRPNADPFGELSYTPNRFMEQVKTWTHLPQKVLMRIIEENYQRCVGPHVRTLKRYEAFTSEVYGELMPSLVYQIVQETKLNENSLFIDLGSGVGNIVVQASLQTGCKSYGVECNPHPAKVADIMMEQFRIRCRMWGVRVGEMEVEKGDMLKSARVHELLSQADVVLVDNKVFEESLNEALRPKFLDLKEGAFVVSLKPFVSSVNARVTERNVDDISAIFDVTERPYYPGSVSWGHGSGTYYVHRVDRKGYADIREKFENSRPSSRSRTRTKWCPDPSDPDDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUQ1</accession>
    <name>A0A8H5GUQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUQ1"/>
    <dbReference type="OrthoDB" id="2898134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32784" checksum="C443A691A4426563" modified="2022-01-19" version="1">MPLSPLGSSSTSNGPALVLTPSNGPPPVCLSPVVSSTPSATDELNTHRPFILNVRSWNLNGSYDCNSSHPKFKDFFDGIDVFMIQETHSYAHENLLAPEGFTLYSCNHTCSDYESPWGGIATLICSSLNAKCIDTCNVFILNGAESIPGNHFHFMEHHNTSKDDQDENIYQCTVIDYALASMECLPFITNFEVSPHTDWSDHSFLSLSIILPGGPPSLPSSSYSHLWPKFHTPLILDLDQLLDNLMKQPSPSPEEQWSNIYGLATLEGHACPLLVVHISGTCSNKGQSNATTGSSIFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVT5</accession>
    <name>A0A8H5GVT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_005064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVT5"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5372241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22129" checksum="62C63BBECA90DCBC" modified="2022-01-19" version="1">MSWILEDFGGREDGLLVGGLDEVGLEILGKGSLSALKGLLAGRWLLGWVESVHHVAFAVGDIRPIFAFYKSLKLTKLVVSATPSRTLSAGAAETVLSTDNTKSECDTRMLEVLVVPGISGTPMLSSISHAHASAAHFPLFFPCAQCGYPSAKLRSYEWGQKAKRRKTTGTGRMKYLKHVSRRFKNGFRENTAATKRVKASSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW43</accession>
    <name>A0A8H5GW43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW43"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034046966" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5372133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="40451" checksum="15CEB4CA4547275A" modified="2022-01-19" version="1">MISTTWLLLAASLCTTAVATATPQKITLTSRVAPVGKSLKKRQLSATNVPLADFFLGTDLQWFGNISVGTPPQDISVVFDTGSSSLEFASTLCTTCPQTKFDSSKSSTFVDTGRVSQISFSTGVGVDPVTADNSYVLRLRSGTDTVTVGGLKSTNVALNLITSQTPTFNIDPFSGIQGMGARAQGFFASLINQGLPSLFGMFLTPNAIGNAELTIGGIDESKFDNEIMFAPQAGTGNAWELRSPGISINGKTTSLLNTPRTIIFDSGTSNVLFSTDTTEAIYAMISPDIQPNPQEPGTYGIACSRIPSLKSVIDISFTGQNGVPFNLTIPSSELSVGPFKSNPSLCQTLINAFDGLELVGGSLLKHYYSVWDVGNQRMGFAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXD1</accession>
    <name>A0A8H5GXD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXD1"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5372964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="669" mass="72786" checksum="F2D222409F14F1F7" modified="2022-01-19" version="1">MLDHCSISHKGGIVLWSRSFTPEASNIASSSASPVNSLIREALIEGRTTDQRYEKDGYAVKWTFVNDLELIFVVAYQRILQLTYVDELLAALKTLFIKLFEPILTTFVASLHAVNSGKAVAADAISNWNFSQAFQDWDKIFDKVLKGLEEKAAKERKSRLGAPMRSEPPVNITPPSDDQSLAPTQSPDTPQDEQQIARNVQALKDRLRGRGGRRGGRSGGRFSDAGSGRDSVPTSDSETPTKKRSKTKAQRKWGDEAPTETDMASLDFSLDKIDSNTNLSSQDPQALVDQASLGTRTRDGLYEVKDWEFTNSEMDETDNVITKALRSKEAQTSSKGSLGALGSLFARLTGSKVLTEQDLKPVLDGMKQHLMKKNVAKEIADKVCEGVGESLVGKKVGGFQTTNAAVRLALSTSLTRILTPKTSTDLLLSIRTKLSSPLPSTQQRMPYSIAFVGVNGVGKSTNLSKVCFWLIQNGLRVLIAACDTFRSGAVEQLRVHVRNLSMLGVNGAGDSKGRVELFERGYGKDAAAIAKEAISFAKDNDFDVVLIDTAGRMQDNEPLMRALAKLVAVNNPDKIIFVGEALVGNEAVDQLTKFDRALRDFSSGSGSGKERGIDGMLVTKWDTVDDKVGAALSMTYVTGQPIIFVGCGQTYTDLRQLRVGNVVQAILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY84</accession>
    <name>A0A8H5GY84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY84"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="644" mass="72984" checksum="BF5347D57BD25BD0" modified="2022-01-19" version="1">MYYINMSSNNAINNTESIFNVPILNTTIMSFGTMLSPASLKPKGLAGLLQFLDDKDEQALGFISSYLPNDVGLEMREFTRDEIEEDPCAKAKGDYTAKMLWDKIDKKYSSPGPTSWFLDFKEFMSWMLDEKKDPANQITSLGAVLTRLKAYGFTVDDKFRALFLMDRILQSWGNYAQFTLATIEPKNLTMAHFDSAPNWNNQKAGSSKQKNQDKGKGKQPKPQEPSKTVTTGDANQGGDKKKKTRRSKKKKGSKKGAANLANPEVEADSDSDDDAPLMVTAFMANPFINATLDPIEISDTDDLPETYENNDSSLKERVKRNLAKQVRPQTISGYFILTHYERLMINELAQETVDFESFLRVEARHQMTRKLAEIWDYTYNSDGTHTEPYLRAKEDLNGDENMTNQWFDHEETIRPIQKQIEEEVEYFCRYIMNKALADMRNHKWIPQQFKKREPVPSKPPSLTERAYWPTPAQSVMRTNGVTINTQFHDTSLYPDFIRTLPFNHTKASSSSSSRKRKAVRGSSSSESSDSTSSDHSEESSFKYIPPSVAFKMWQDRMSHMFTDPILENMKREPDESGNTSKKPRYDAPLEEEAGPSSLADAINVSISSGYLADDDGVSLGSESDVEIYIDGDENYGFLASISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZB7</accession>
    <name>A0A8H5GZB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZB7"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="34959" checksum="DC6EB628C496386F" modified="2022-01-19" version="1">MAAISFQWYKNQGRETAQKAWDHLVLDPDVKTLIKGLVDVTKNENTTTRMVTNGISGKGSGLIAVLHGPPGTGKTLTAEAVAEILQRSLYMVGSSELSTSPSSLESSLKSILKLASAWDAVLLIDEADVFLEQRSLHEIERNALVSVARQLFMFTVRVLEYHRGVLFLTTNRIKTFDEAFLSRFPVAISYPELDQMGRFAVWSKFFELAGDQIADSNSEFKENETQSQPFNGRTIKNLLRTAQALALSSNVPLSLQHVQTVVNAQEKFLREFSEAKGLKRKIEEVDGDEDEDGSSDSWPEGSSNGSGRPTIRRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZG5</accession>
    <name>A0A8H5GZG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein Crb2 Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZG5"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein Crb2 Tudor" evidence="5">
        <location>
            <begin position="683"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118513" checksum="E6526B9310CF7822" modified="2022-01-19" version="1">MDGNSDSQASQILANLQDRREASKHSTASESLNSHATCTDSSLPKNIRSSARYHFHGLAATQTTQTETQLNSHKDDQVEQESQKENIHSPVPSADQRALNPAVAARHLSKGSRSPVPSNATKNKGKAMSFQSPACTNNIPHTDSATSSPLSTPELVDHLESSDSNPAMDIGTILVEATQEPESQPSQVEEEEESQTYFPDPQDDGLYGAQPPEDFDMDVEDSHPPSQQPDEPSLGRDSPSQMTDVSSQDAQAFWDDQNNIPRPQYVETQIEETQPVETQVEPAETQMATQLETQPDDEPQQIDVPDACWRAYQIAKGSKNPMMDVSRTKRWSYMRKDYETDVPDEVWVRYWKERKVNPMDTPTGRRWPYLLKDFERVASEEDQTNPLALQLHDHLDTPVNPPTDEVLSQALQETQLADESDQAYAVRPNLVPPRTRGAFTRSGSLEATAEDAMDIAPDFLPTRASSIQATSTRFNANDQSIVDNEDCCPDSEPARGGVALPATSTASKDHGSSRKRRRSDDEDEVSDPTKLHDESVPDSTEAEPDPNQNIVDSDEDEDEESIPLYEQFVASEQQTRNKTGSMEQMPPPRETRSTRSKGKQRADSTPTAPSARKRQRTVGASIEATPMRTRLSSKPPVTPNDNTPGPSTSTSKTRSNSKKREASVASSSGSSTKAPLRLHGPDYRVFALWKQDAHYYAGVVTEIENSGYTVAFCDNTERKDIAIEHMRIFDLRRGDSVVYGEHNHVGTVSRVGEDDIHIIAGVNPRPQLLHYKDIKVSSKTVESQWTNRMLTEQMIKTIGEQESRQFLYVGKSVDINTLDHFLRGCAIVPSFSSTDPTEREQVIDGLRGVLETQSGKLLSDWHDVIHLKGKKCTQHWYIESKDVRWKGLEDIRRLYLVGDDTSQKAKFLFAIAIGVPCLSKEWLEDEAQIHEWNRYLLTQGYSDHLHARISQSVDLDWGNSVSHLEEIMDNPVPPKLFAGKFVSLTKSVGIPHIILGMGARRVEYAKTWENASREKGSCDYIVFVKQRPNIARMPRDCRLVSWNWVKQCLITGRMIPGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0C3</accession>
    <name>A0A8H5H0C3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_004656</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0C3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5374322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60793" checksum="0B211F9610C4CCD7" modified="2022-01-19" version="1">MQSAGYGRRVQTITVFCTHHKAATRMPLSYKDQITDMPQWDILALVLAVLSGLYLLKRSRHRYPPGPRGIPILGNALQLDTMKPWHTFTKWGEVYGPMTYLNVAGQSMVIVNSKKVADDLFVGRSSKYCDRHRFIVLEETTGNSIIAFLRPGERWRKMRRATDHAMGIKASSNYRRTQVNESIILAHGILNQADTWRLHVERTSSSIALSMIYDKPTLQSLDDPSVVFMNGFADRIAKVAIPGNYIVDMLPILEKLPLCLSQWKQEAQREFKRFTSRFEEMFLEVKKKVASGHEQYPSFCVTLSENQTKQNMSDSDCAWLAGALYGAGHETKRAQDELDRVVGSSRLPSFSDLKHLPYTQAILKEILRWRPAAPTGLPHIPIEDDFYDGYFIPKGTMCIPCIWAINRDPDVYGLDGNNFRPERHLCQDGHLKDETNEGHVTYGFGQRMCAGRYVANSSLFIQMATVLWTMKLEPLKDSKGQSVVPDVDAEEPNGIFTRPPPFQFTASPRFPDSEALIQQARDEIMQEVLSRPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1K6</accession>
    <name>A0A8H5H1K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1K6"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5375002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="63" mass="7378" checksum="379F28A656DD0E88" modified="2022-01-19" version="1">MDSFSSVDLDQEDEVPLRQVDWHELEPIHKHDTELKKQREEVKAQILYDEKGYSKEGGEGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHJ1</accession>
    <name>A0A8H5LHJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHJ1"/>
    <dbReference type="OrthoDB" id="2799385at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="34957" checksum="159AF6DA72D0F30D" modified="2022-01-19" version="1">MPDTKKKVIPKEGKEFLKTVFHRYQVLLPGREEREHVLRELKHVVPGCEDVTMKMVNKWFSEERKRTGGQNTTLSNSKKCHLEVWFTQNPEPSEDVVTLWSKQLKVDRKDVVYWVVHKMFDRTSFQPALPPPPEQVALETVIHLYNQAFSPLSPVNGAGQNTIPSFQTSGIDAPMSMDYARDDAHDVPQSPPHDDIMDIETQTFLSEKFLPKVLFSIAADEVDRFVTGRAQRTMKEATGHEVTLEIDSKRCPLQTAQDVKDLFGPCHRLFDKVMELVDHKKQTDPRANLPMVEETLMHVDRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHT1</accession>
    <name>A0A8H5LHT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHT1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5357624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16417" checksum="56941777A1F692EF" modified="2022-01-19" version="1">MLPELYIVARGNCLKLDLGKNAARDAPNASPPWLHLQIMFRTSITKQEKYAELTAKILDAVSPLTHVRFVHLEIPRDFFTMKALKKPLSSLDGVKILHLQSESGGDFFKALLQPKRKNSKKVAIFPLLWTLSLKDVDFGPERAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMH2</accession>
    <name>A0A8H5LMH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMH2"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="195"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="572" mass="64221" checksum="1125409651A5E882" modified="2022-01-19" version="1">MTLDNVLTSNPPTLSRLTTQVNFKHQPSAIMNLTPLRIALYFALSLFSIVVLGLAAARLKYTLNLPRGDPLNFGNNFHESIVAELLATSILTMLWSWYIIHVIHKRREHGLVSSFRRAWIPLFILWVMWLVGAVIATFSLFKRLPFGVIVIHNAGLVRTTEFLPIDSTSPPFWTLLALYTSTVCFTNVGVIFWPSLFTPIKLGPYTLQHRVVLAPLTRLRSTRDTNVPQNPTMKEYYSQRASVPGTLLISEATFIAAKAGLFRHAPGIWSKEQIAAWKEITDAVHSKGSYIFLQLWALGRAADLSALQASNPSFELISSSDIPLSKNPSPRPRPLTTQEIAEYTSLYATAASNAVHKAGFDGVEIHGANGYLIDQFLQDVCNKRTDEYGGSVENRCRFALEVVQAVVDKVGEERTGIRIGPWTPFQEMGMKNPIPTFSYFISQLNSRFPNFAFIDVIEPRVFGGNSEPASQNLDTGNDFIRDIWLPRPMISAGNYMRETALMQTDEYGNKNEDAKKGQMIAFGRYFISNPDLPERLEKDIPLTPYNRSTFYLLGDTTGKGYTDYPFADEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMI9</accession>
    <name>A0A8H5LMI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMI9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="26721" checksum="9A721139D71553ED" modified="2022-01-19" version="1">MLCINILCACLAPLSRLSIVPATWMLFLLLFSWAAASSCDRVLSLPTSQPALFTLMHSVPALSVYTVLLVAMIHTGDMVVVVVQLLLVIGGIALLVLLLWKQVYQREGTGVTVDGLSHSDVIHPVGTTAIAAPQCLPPSTTVVSNGTAALPSPAIAAVSCSPCLPSSSTTAASNATGITARTPTSGTALESSTAHSIVASPPSCSGSSSAVINGTTSGSAVVLTAHDVAVPLPARVRRLPRSPDVPFQRNDLTSSCSTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQH8</accession>
    <name>A0A8H5LQH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQH8"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19493" checksum="2CD949D02D3977C3" modified="2022-01-19" version="1">MPDMVPLDHAGPQQRQFNPYSDNGGTILAIAGADFSVIAGDTRQSEGYNIQTRYAPKVFRLTDKAVLAVNGFAADGNMFVKRVRQRLEIYFKNQTAAPGTTHPKHLPLQDVLGLVIDSFTGATERHIEVGDGLEIYIVFAKGSPLQGLENVPNVQEMTMTSDGERMFIIRRELKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQT8</accession>
    <name>A0A8H5LQT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_008916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11"/>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQT8"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034210299" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="37"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5366575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="23253" checksum="EA5F526DB8582E03" modified="2022-01-19" version="1">MFSLSSIFVTAAAVASVFAMPATNGTEGEFFGLVQRAGTPSSTGTSNGFYYSWWTDGAAQATYTNGAGGQYSLSWSGNNGNLVGGKGWNPGTSTNVISYSGTYQPNGNSYLSVYGWTRSPLIEYYVVESYGSYNPSSAAAKKGSVTCDGASYDILQTTRVNQPSIDGTQTFQQFWSVRNPKKNPGGSISGTFYDCIYPCLQTHLYIYPLLALMRLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRN3</accession>
    <name>A0A8H5LRN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pheromone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRN3"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5367027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70196" checksum="5C59D5932820BF80" modified="2022-01-19" version="1">MSSAATDILYSVLSFLAFVLVLIPLPWHIKARNAGTCLFIGWIGLACLVLGVDSIIWRTPKGTSDSIYTWCDISTKFLIGAMAAMPTLSLCINLRLYFISTDRVGILETRRILVTELVLGLGFPILEMILHFVIQGRRFDIYGGVGCLPFVPNILLTYILLLAPQLLAAIASTILLVLTIIASREIYKKINLLHPGINDHEGSPLTFIWFLTLGGLTALGSICYDGYWIYATLSTGPMKVWVPWNEMHNTSQVDIISQSHWKDQFKLGVMLQIDRWIYVALGLLFFGFFGFTAEARRRYRGLAGLKPPDVERDELNEHELTRIMKSRGLRPKGAPLIISKPTEAFSSSQSTFLPAIDGRGSFFHADPDVTFDSVKEKITGQSAPPSAVGPFSPNDDVHSVASTSYPTIIYSMPHHPETTFGSSTTASDTTTSSTPYASPNLSRSIVSLPSPSQPPNVPLPPVPGSPNVEMSSHYSNSAYGANTHSIYSTSNYSISASSLPLVSSKASTVTAAVGHGTPYARSPLTAPLQRARSLSAASTRTYTSTSATTTYTAASVSADSSQAGRLQQSSQQPYSGRHHRSRSTVRRQHSTARTTTTTSSAHSHSQSEHGQSDPSGPSFLDMRNSQKESALFLDRATGNGMGVGMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS47</accession>
    <name>A0A8H5LS47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS47"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51495" checksum="7389F7B2512D5000" modified="2022-01-19" version="1">MARGISASPRIQVFKEIACRALDLTTTECSTSNDVQARAARIQASITTTMSVLSAIATGPWSRWGDLHGRKPVIFLTMTGALIVELVFILVTRKDTFFYNHAESLIIVGPILDGILGGLSAFNGVLHAYTSDCTRHGSRATVFSSMQGVIFIGLALGPWFNGLIFSLGDFSPYLPFFMSSSLLVILLAYLAFICPESLPPDEARLGEENMARLSGGRSNTAFDNMKYYSSLFIAGLLSPISTFAPRTVRTSTYTARDWNLTFVGVALFIYLISIGIYPIKYLYGQHTYNWDTKELGFYMSLLWIARAVNLLLVVPIIVYRYKPKPRNGQPVPIEEELRFDQRFSQISFAVDGSADALIALVPTSFQTAFVTLSCVTSFTSGGNPTLHSLGAVCLHANGFTSEVGSLFGAMAVLSAIAHIISPFLFAGTYGASVGTFSKAIFVVAATLIFTSVTLLGFIRTRMRIPGPDVRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSJ1</accession>
    <name>A0A8H5LSJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSJ1"/>
    <dbReference type="OrthoDB" id="2146436at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF11">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034849492" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5368420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="218" mass="22575" checksum="B69BBAB6C74D899F" modified="2022-01-19" version="1">MRSFTAFSLLGFASIAAAHFQLQFPGPRGPFVEDDEPKFCDGFDNPATNRTQFPLSGGFYALNSEHPTWTVFTLLSNSSNPTKFSDFEQVTPFAQLNGEGVFCLPLDFSTSQNASSMGLKAGDNVTIQIEFVADDGRLFQCADLTLSDSVDIASAFSCTNASQQAGSGSGSSGSSGNSSDSGNSSSSGGGDSGATIETPSLKLAISLLGALGLALVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUG9</accession>
    <name>A0A8H5LUG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUG9"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5370012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="619" mass="63892" checksum="29E3CE8ECAD24E11" modified="2022-01-19" version="1">MAAFGGNSAFGNSLFGASSTNQPAAGGTGGGIFGSFGQNPTNQQTQQPTTSIFGSTSATNPNNQQQQQQPTTSLFGSTTANTQQQPTTSLFGNTNTNTAGSSTTGASNIFGNSTGGGLFGKPATPTPTTGGNIFGNNTITPNTTTPSTGLFGNTTTQPAAGTGSSSFFAQPPAGQQQQNPNAPKPGLFGNSTTSINPLFGTQNNNTATTSGNTGTGSLFGNSTTTTNPLFGGSNTAGSTPSNPLFGSSTTSAPTANNTLFGTSTTGTGTLFGNSTTQPANNSATGSTLFGNSTLGASALGAKPATGPSGANGLGASSLTQTQGADAQVQFARLQEKMEAIVGAWNASNPATCRFQHYFYNLVDPTQVKLYGRPPNAVNEALWQKAVRENPDPSCLVPVLAMGFDNLRDRVDAQSQQSTAQKAKLGELKDRLQSLTTHHTTTTVPKLQQYSALQTQLMHRLLKLVTHLHLFIPSVRSSAFGENEEMLRSALEEAAAEVGLNGSNGEGRRVRGGKINSKLGELWAVISQLKAREESLAASMGTAGEWKVVDEEGLARITQILAEQQVGLAHLMKILRKDLKDLGIIMGTAGSGAIAEDGDSERVFGASTLRESALRASAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVG7</accession>
    <name>A0A8H5LVG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVG7"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="23565" checksum="F7546FF22985BF2F" modified="2022-01-19" version="1">MGISRSSRHKRSASGAQRAHYRKKRKFELGRQPANTKLGAKRIHTVRVRGGSLKYRALRLDGGNFAWGSEHVTKKTRILGVVYNASNNELVRTNTLVKNAIIQIDATPFRQWYEAHYAQPVTKKGKTTTDASAEPKKLSNHAQRNLDEKKKDAKIDPLLESQFAAGRLYASISSRPGQSGRADGYVLEGKELEFYVRKIRTGKQKHAHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWQ1</accession>
    <name>A0A8H5LWQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWQ1"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5372845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="34138" checksum="AD2A11FF632EBF70" modified="2022-01-19" version="1">MSSKPKPKSHKGKRQTTKPAQKRPLPVPERIKRHFSSLCAQIDGGHFANAIKTCDKILRLDPNDQDALRTKLFLYLQTEQYLPSLDMIESESGDEHAFEKAYAFYRLQQEDEASAVLEDIKKKKGGDDRGVMHLEAQLSYRQGSYQSACDLYNQLLDTAEPQSEEYSDIVVNLQAAQQHLDFINSGYLQGIDSLPSNLRNSIESQPPPAFPSSTSAAAIIASSNQAADSAQPAQKKVRAKRVPKGVIPGVTPPPDPERWLKKSERTTVSFGKKRKGAGGGASQGATQGANVDAHAPSGGGGGGSGGGGGGKKGKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYJ9</accession>
    <name>A0A8H5LYJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYJ9"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="2">
        <location>
            <begin position="73"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="799" mass="87942" checksum="972FA2FAA556E533" modified="2022-01-19" version="1">MPLRASTTAYNVPKYSYFKSLEELDQWAAQPPLFFDGVLPFHPRSNRDDIRTRGKLLLCHDYKGGYTESPFTLSYTFNYWNSVETFIYFSHHRVTIPPPGWITAAHRQGVKMLGTLIFEPGGEADCLRLLVGQLPKSRTGPATQAPPTPSLPLSPHYARLLAELACQRGFDGYLLNFECPLQGGPEQTRALAAWITLLQEELKQKVGDYTEVIWYDSVIVTGQLAWQDRLNSVNLPFFLSSSSIFTNYTWRTHYPSLTAQYFLTLDPSLTGSDPKSHHVGSKTLQDIYVGIDVWGRGTHGNGGFGCYKALNHISPDSLGLSVAIFGHAWTWESEQDKPEWTWHTWWDYERLLWAGPRRIVNATEKEKVPIPEMPPPKKGEEPCEHGDFVSICDFFPTKTPPDPLDLAFHTTFCPGVGMSWFVDGIKVFDSLSMSTESKSRFTGWTDIHQQTSMGDLVWPNPTLAWTGDAPLEGVRIPEAVAEVNMDDAWNGGSSLRVVLSDTGNQSEDAAFRCVRLPIQSLSISPGRSYVATAVYKIEAGGSEVDLDISLSTALLSSSSGDGSITSTAASANDTSLGEGWTKLGLQFSLPETAAAPNAQDVLVSIDLTIVIVSEDTTTPLRLPILLGQMNVYPSHPSSVPAHTPSILWADFKPSPSPTPSASSTSTPSSSSNSEVSGTISWEIAAALPPINLAPITSPEDTTPVWPTQPSAHRWSWFPKVMYTNVYAQKASGSGSFGRPEDALWIGTSGYDGTRNVFTLGEGVLKTLELGLRDKVRFYVRGVTDRGEVLPWSQSVWVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYM0</accession>
    <name>A0A8H5LYM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYM0"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034186923" description="Macrofage activating glycoprotein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="39012" checksum="0C30077F41C224B7" modified="2022-01-19" version="1">MNATSITVAMLPSLLVALAASSYAAAQSFVSDPLVDKVVPYTAIPYQVDQHTADRGPQSGYNICNSTTEGQNSLCQTGYVNHLDDFCLFAPPEPNTVVGSAEGIAVAWCTKPGRGTRLIPEGTLKGIQLVQSPGYVQVAGLIDQTKINIQAGDFGGELDSGGQDGRGNPIGGLIYSNAFPSNGGNNDTFQQSRRWTLFVGNDAFCFKACDDTQPNAKALCEHIYDRIGCTYNAPNTAQEGVFERCDGDDMRPVGQYDGPNNETLTWTQPPESLGPITSVPYTPTPAPSSNCVRYASEDLYSQLNSVSADPAVTGGATASGTRSTGASGSRTSTGSSASNTSGGSGTGNENGAAAAASAMGISVVAGVSSVILSALFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZB0</accession>
    <name>A0A8H5LZB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZB0"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="311"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="404" mass="44733" checksum="E8761173651F9F88" modified="2022-01-19" version="1">MNPLSSPRRNPSTRSARRRAPSHLPAQDTHHVALHSIRSFLKGRTCYDAFPISFRLIILDTKLSVKKPFIACSSTVSILPCLCASSNHLPGVVSAPLWNSEKSEFAGMLTVLDIIHLIQHYYRTASYDYAAADVETFRLESLREIEKSLGVDPPPLLRKYPYSSLYEAAQVLVQTHARRLPLLDYDTETGHEVIVSTLTQYRLLKFISINCSKEIQQLHHPLRKLKIGTYVQSSDSNPTDNPFYPIATASLDTTVFDVVHKFSELSISAVPIIDENGIVVNLYETVDVITLVRSGSYQSLDLTISEALKQRSPDFPGVVICTAHDSLGTLLQLIKKRRVHRLVVVEGEEEEKKGGKKGRLLGIITLSDVLRCVIGASPPEPIEPSTSVPQSLSTPDTTNTPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AYG3</accession>
    <name>A0A8H5AYG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000532">
        <property type="protein sequence ID" value="KAF5313309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AYG3"/>
    <dbReference type="OrthoDB" id="2742418at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="271"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5313309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="84142" checksum="F8831E95C9F850CE" modified="2022-01-19" version="1">MHHVWHEEHTWSSRFKVASQAEGNDTQGPSSFPSFRLVQEFFTEIPRYAILSHTWEDEEITFQDIQSLITLADTCNGRQLTFNDIQAFLPPTQLKKGYMKVVQACVCARNSAFDWIWIDLCCINKESSAELSEAINSMYQYYEDAVVCYVYLFDVSGKLHPKNPASDFKRSKWFTRGWTLQELLAPEFISFFDKDWTKIGTRWSLRDVISVVTTIPMDVLGEDSIEKYSVAQKMSWAARRETTRPEDKAYCLMGIFGVSMSPIYGEGGSEAFMRLQQEIIRISDDRSIFAWISDSLEEQGLLARSPSEFRYSGQVRASNTHAIIDNSPSSYSFNNNGLHIHLPLEPRHSYPDVSLAPLYCQTNNGRFVSVYLRRTTGGYYVRHDPDRAVLGSASPLTDIRELTVREPLILRKSRTRIPAAGKHVVSLLPSARHFICSQPLQGVSISTEFSVEFEISNSSRSDPQSTNLTYKFPWKFDVSDVWMSGVFPMVIECDYSLWIGDEGVDFISSDHPRADCMLGPLSNSCFVSACLEMRGDEKKVFEVDYFSPEDSRSEGVATTVGSDLDVWVPFVFGSYDQEEEDDRNTCVTVPYSDLLVLKYTKREKWWMLSLNSLSDSDLDCDSETERRVKREEKGTEQGGPATCYIAVGCQQQMPWTHVTFNGKGTDDVRDNLVKDEHLYDQTSATDTFKHKKLRVWIAPATELNQAFHKLHFEWVEDEDDAEDEKGMRRREGRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B633</accession>
    <name>A0A8H5B633_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000478">
        <property type="protein sequence ID" value="KAF5317479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B633"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="681"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5317479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="889" mass="94755" checksum="53BCC14B8B6EB27F" modified="2022-01-19" version="1">MFVEKTAEDRAKIVDGGARNMSEIKKWINAPDSSINFNAAHDKMTKGTGEWLLKDSRLVEWKEKGGLLWLQGKDDPEPIKENELCNIISSTLVVVQEVTRWYGQKEDILQLGHPSVKEYIVSEEIKASSAKLFQINDQLAHEFIAQSCLIYLVVCGKDGYISQNQFPLADYAAKRWTEHVRNLQALEDPLKSLSLHLLTDTNMSCLAWMNISASYYLVWPAAGSAPPFYYASMVNLPNMILSMTEKGEDINAKGGKYGNALQVATYFRQIEIVRLLLENGADVNAQGGEYGNALWAGVYLDQVGIVKLLLENGAYVNAKGREHGNALQAASYEETIAIVKLLLENRADVNAQGGEYGNALQAALYRGNIAIVNLLLENGQLVDIVKVLLENGTVVNAQGGKYGNALQAASCHGSVDIVKVLLEHGAAVNAQGGKYGTALQAAASDGSVDIVKLLLENGADVHAQGGEYGNAFQAASHRGSVDIVKLLLENGADVNAQGGEHGNALQAASCTGSIATIKFLIKNWADVHAQGGKYGNALQAAAYRGSIDIVKFLLGNDADVNAQGGKYGSALQAASDRGKIAIVNLLLKNGADVNAHGGKYGNALQAASYRGSGGNYGSALQAAAYRGSIDIVKLLLNNGAAVNAQGGEYGNALQAASWKESVDIVKVLLENGADVNAQGGEYNNALQAASYDGSVDIVKFSAQEWGRYIVKLLLENGADINAKAGKYGNALQAASWRGSIDIVKVLLENGADVNAQGGKYGNVLQAASSGGEVDIVKFLLEKGANVNIEGGKYGTALQAASVADSDLLSDYNYVKLVEILLDNGADINSRGGKYGSAIQAAAINSNQQIYDLLIQRGADGIDPIFTIFQEDPKIPFPFMENKSADSQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BC69</accession>
    <name>A0A8H5BC69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000406">
        <property type="protein sequence ID" value="KAF5320567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BC69"/>
    <dbReference type="OrthoDB" id="3260975at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5320567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="521" mass="58229" checksum="C3725B1CA760BFAA" modified="2022-01-19" version="1">MSPTFPVHVPSSQFQFPDPEPTHIFSRLPYTLALYCSQFFNNSHSPSPATRNSSATLTGPDFDLWFTPVSWRESQPIISSSSESSVSSLSESDDGLLPLPPYNTPETSPAPFPENTAPNPHPNRQRIMPMEDLSLFYGDGRTSENPHVFIKKAKQKLSHLNDDNDHIENFKDFLFPSGPAEVWYEEVMEGEAPPVTWKALVAKFEKRWPKPVQVKKGPGDYVTELSAYRMPEDELGRKVEKGGVEVWSHIKMADELNELAHNAGIHESDFLIVLVWHNLPSILQGLVSSVQKDWTSFRESIKAADIEFIKKEVKKLEQEKEKEKEKEKKEKELMEKYDQILGMAGPAPETPTRGLTGRFAAASLGVNVPAYGGPRGGYKGGGYGRGYGGGGGFRGRGGFGYMQRGGLFRSPQCNYTHLTEEQRKALRHNATALPQHPNTTAGCQAYEAQKAEWAQRWGGNATLVTYEHPYPLELGTSNVCTGECFQCGKCGHWGDTCQTRTLNEKEKAWRRLCSNKLGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BW53</accession>
    <name>A0A8H5BW53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000335">
        <property type="protein sequence ID" value="KAF5330091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BW53"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="5">
        <location>
            <begin position="31"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5330091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="224" mass="24251" checksum="7BFF7219658122B3" modified="2022-01-19" version="1">MEKLFATISPFSIYKGSQPKQQGPEVPQEVRYAKLTYLPFLLKMLSQVMMEWPIFRPTIADSSSSSLSPSTSTKLSLSIHPHADIALALSTPTVILTHTEECGTRYIAGEVKRISKLARGQTSRLTKEDFDGTSVSSGEDSKTRPHKGATLTASNVGAIGHGTSAHPVLILGGGVAVVAVGRARWEWDVYPGYDDYRDTFDVVSLGFDANSESGLQEALLGYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZ59</accession>
    <name>A0A8H5BZ59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_014584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZ59"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="389"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5332028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="563" mass="62110" checksum="E41B64791A3CC1BA" modified="2022-01-19" version="1">MISSPSLASLSSASSPMPPTLTTSVATTSSFEGSYASKDKKRADKHVASTMAAASTTSDEDLRAALEQVKKEEVPAAPEQKEAYFMSQVAAGEQMSVLGPDHHLTAALAFYRALRLVIELTNLDVSYASSTSQPQDELDGLDDETSPVREGPPSETSSQEWDKVKDRVEGYYQKFPPKSLGVAVETRKLPSSETSKKVLVVKKDVKAGEVIYEEHPVIAALDYDLQEAGTHCSHCLRVLDPSTAIKISQDPINTVFCSKECQTAAKNQSHALLFTLERPLPADIPTEPITPAKLDSRRKAQVQYVEHLKKVNKAAPLLVARFIARQIALEMGKLIPGASVAEDQEKDFIDAEGGEYLLADHLERLRYLEVAADKEEIALITAVLESVLPGLEQFVTEERYTVFLGKMAYNGFGVFYGEGRDDKARPEDQERTRTPCGTSRQTGTALYTVSSYLSHSCDPSARPSFENGTSELRLIATRDLKAGDELTVAYVDVTQHEDESIVDARRRRRMELARGWRFACECDRCLEEAKTLDLVTATEEKIKDESKVEDSVSHYQENEGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0V2</accession>
    <name>A0A8H5C0V2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000302">
        <property type="protein sequence ID" value="KAF5332886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0V2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="423" mass="46121" checksum="CF018FAB4164A73B" modified="2022-01-19" version="1">MVPLLLTFGYWTDSRNSNVVAQGRKAAPFDLKLRWGFRIIYQTSSCHSDQAGAIHASGGALRVRETTSAPLTDVTNSLALEEEAAFKQQRVQGWQQTVNKEANHYLDADQSNTSEYDTVEDSQKLLSGDENVELSTVTKEERVQENLQGPPTSVDNDRVPPEHDELVLQPSMTGQEGETDPDQQIGYASAGLQNPFSECNYSHPAANYPLSFAGPDGVVYFNLDQQPCLHWQYLLFEQTYHQHYYQHYHAYHSDDVVYGYPQQQDMSTSASAQAYDSDDYHPNSTLDVAADAGVPSSGPTGADTSGSDTNVASGANANLESGAGKNNLNDDDVVEASSTQFEVPLRTRSAPPVLHAYGASSALAYESEQGVSLDDVWADWQWRVSPSTCPATQDLKTAGHQKFAISPNFPSSSTRMVGASTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2G7</accession>
    <name>A0A8H5C2G7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000277">
        <property type="protein sequence ID" value="KAF5333960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2G7"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="32938" checksum="A28EED68A608EE70" modified="2022-01-19" version="1">MTSRSPPSPSAPNSVSNGRPRSCSSSSRFSSSQPGVVPTKPSSHAVLNSSGTVASHASSSPSPSLARQTSLPSIRSLHPYLPPPATPHQPAHGRQMGFPVSGLAEPDRDREPRLPRENHSTSSLSTPSVRDLQTLSRPVPVPSPLSTSPYTYTQLYPSPSHSPHRPHSSLIHPHHPFPSTHPPPHGPSLSEPYYTSHPTRLPHAIHVNPHLSSLQTMPTGSVGPAGPDHASINHKRRLSGSTTSAKGLSDVGEFVDVYRSSDIGTGIAGTGSDEDTERLEPGQPKRKRRRQALSCTGRSIIFVSYSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2L1</accession>
    <name>A0A8H5C2L1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_018206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000283">
        <property type="protein sequence ID" value="KAF5333846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2L1"/>
    <dbReference type="OrthoDB" id="621413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5333846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="43147" checksum="86A930AA361717CF" modified="2022-01-19" version="1">MFAKPGDICSMLDQYEDAKVMLEQAKEQFEGVGSRLGAAQCLQSLGNICSMLDQYEDAKVMLEQAKEQFEGVGSRLGAAQCLRSLGDICSMLYQYEDAKVMLEQAKEQFEGVGDRLGAAQCLQILGDICKMLSQYEDAKVMLEQAKEQFEGVGSRLGAAQCLQSLGNICMMLSQYEDAIVMLEQAKEQFEGVGDRLGAAQCLKSLGNICRMLSQYEDAKVMLEQAKEQFEGVGSRLGAAQCLQSLGDICSMLDQYEDAKVMLEQAKEQFEGVGSRLGAAQCLQSLGNICRMMSQYEDAKVMLEQAKEQFEGVGDRLGAVRCLRILGRIDHAQGYLSPAKAKFEEAKELFEAIQMPQEVGICENCLQRVNDDLAESMASRKTWRRVWCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4E8</accession>
    <name>A0A8H5C4E8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4E8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5334569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="17419" checksum="07CBC79698E28DCC" modified="2022-01-19" version="1">MPQWAGGMFKGFATRLRLSLAETTELFLNVNMTLSCYSNLNILPCRCMPGFQNLNTSRNRVYQNKPLFDILSNIPSDTVIPSDMPHDENFNHGAAGRLFNGRPQLDVVDVEEEKVPSVTGDDRLGDQCFCLLGTFSYGCRAEDLRTPPRAGLLGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4N7</accession>
    <name>A0A8H5C4N7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000247">
        <property type="protein sequence ID" value="KAF5335059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4N7"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5335059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="358" mass="39512" checksum="FB050FA733C27CCB" modified="2022-01-19" version="1">MSSLSEITIPSSNSTVSVKAFNILTSTSSAPANVFLEPVLPGRDTMYPLPAYSFLIERGKRRVMFDLGLRKDSENLAPKLKEGFPSHPEFNLHVEKDVVEQLTEGGVELESVDTVIWSHTHLDHIGDMSKWPSSTRLVIGPGSDRRGYPTIPDAVLLDSDFAGREVEELDFANSNLKIGGTPGIDFFGDGSLYIIDMPGHCPGHIVALARVNPDSFLLLGGDTCHHPGQIRPNKHIHKSYPCPGHILESTGKSVSAEHFSAPGTTEFDLSKRDTPLLSVPSPPSAYRDREQSIESQRLLGMLDAHKDIFVITAHDSTLVGIVGLFPETLDDWKAKEWKEKVVWLFLDENNEAFRFSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4P5</accession>
    <name>A0A8H5C4P5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000259">
        <property type="protein sequence ID" value="KAF5334471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4P5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5334471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="487" mass="55531" checksum="F55958E54FA8ACBA" modified="2022-01-19" version="1">MSSEAKFKLLKGRSKKGNLNALHQLGDLASSNPSFYLEALPIYMQHLPLKTPGTSYLKQGPTESHLLAIAALSGIGKGALQLAERTSPSPKMQPFLRQYWPRMWLWISHFTDAYLQTSSAHADDEEPLEGDISRTTARLLAALTRPPLGILDQIFETSGVVKCVVDLWVRAARIDIFDFELVTYYQLTFNALQASRCRPPSEMQPILEDAFDRIDCGFSWVVTQGLITCARGRKVEYEKIASVLGYLETFAMFSPKFRLVFMYQRSIHWVTAIFRKLVSRSPARMTYEDEDRIIRLGSQSLRHLNEMIFSCGHYIVVDLLRNRFLLSLLQAVPYLFVNVPESLEDSEVEEFHKPYFELMENLGAYGNYLSVQKILYQSMEKIENEGSDECFLEDASFLIRSLWNNLKRTAAERHALRRARKEWLRSEQESSTAVQGAYMPVFVAEDARNITGGTTVTNVEKSLKSEMPRASLLWIGCMTVTWNSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA86</accession>
    <name>A0A8H5CA86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_014335</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA86"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="160"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="538"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="787"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5337985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="969" mass="109107" checksum="5ACE7001598C9184" modified="2022-01-19" version="1">MSGNVSRVLNALDISLNASLDVEETSTPNASQGKLAALMQARLTQAQGRLGYMRPEDDDESETEMLFGSQRAFSSTPKVAGGFRLNYDSETPLKAIDIGGADQQQKLAEFVTQTIDNVSHGLTVRTALQRLGLQGPEDILPGMDIRLLPHQAIGVAWMLDREKSKDKGGILADDMGLGKTVQMIATMAMNPPQPDGDDRDVSKTTLIVVPSALLQQWKDEIEEKTNGILTVHVHHGREKLKKKSEIKSYDVLITTYQTLMTDFVVPKDVEPHEEAEWLRKNGGVLAKIKFYRAIADEAQYIRNRVTKASIALAHIQAKYRWMLTGTPVTNTLADIYGLLRFGKFRPWNDWNDFNEYVDRDSDMTDMVPPLYQAKYQNVDAVVAGQRAQTILAPLLLRRTKNSTLEGEPILKLKPKEIGLIKVPFSEDERDIYQSFETKSRINVNKFIKEKSLVKNHSFVLVMILRLRQLCCHPNLILSQTEGLDDPTMLMGGDAEKERARAIKVKGRPWVENIKQKMLIRARADKVIDFAEEMQDVSCPVCDEAFIENKGRILGCSHELCFDCMLDLKNSPIEHNGIFGEGNERENMEIERKFEEANAKGWRPCPTCKSMQDMSDEKTFKLAAFQPTDEELARFIAESRKSRKKKKAVKDELYSDSDDDMGDYNKTFEERELDDSDDDFPDLNDILKPPKKKQKVENTKAEDDDDDILDLTLDDISVPLKTPMLGWSSKNSKKRKSPGSRGGIRKPKGRPNVDKDGLDMGANGPSEAVIAAWSKGDEEMEPSAKMVQLIEYLKEWEDEGDKTIVYSQWTSMLDLIEVLFSRHGIRSVRFDGKMDRASRDHTLSIFKRPDGPKVILISTRCGGVGLNLVAANRIINMDLSWNYAAESQAYDRAHRIGQNKTVYVKRLVIENTIEDRLLQLQEVKVGLAEAALGEGSGTKLQKLSMRDIKFLFGMSKKGPNGNDSGDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAC4</accession>
    <name>A0A8H5CAC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAC4"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034218554" description="Glycoside hydrolase family 71 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56385" checksum="73D2DCA263F6AF65" modified="2022-01-19" version="1">MFTFLQFSLLALGLSVAVEGNHLLSLKSPFQHSRANLKTRHGDSLFSRDVPLPDIDISLARLGSEMLTSTATSEEEEGMSPVHYLAVHPRVDHAQSLAERKYVFMHVRMQSVGIDAVAMNIGGDQWQTDQLYSAYAQAHKTSIKLFISFDYTAFPCDTAETIRVASLFMDHPAQFKVAGRPMISSYSGVCLGVDGWKAVRSSTGGFLMPFIYGEDYQDLREGRVFGFFDSWYWVLMIPDRPSMIDIVRKSAIFSVTCGANDAILLTDMDILGKRYATTVSGGIYTHYDYKNFYLRGEDWLLASRWEQLFDMRDQLTFVEMVTWNDYGESDYFGPLTSGVQPTGTTWATGFPHEAWLDMSKYYIHAFKTGHWPAVVVNEVFFWCRPHPARVNAMNDPLGKPSGWDWGRDAVWIVVFCASSHCEVDILMGSRQQTFTGLSRGVSKVKMDLGADDAGPITVKMFTFIATPAGPGRRVQVAEHSTQGAFEFEQSTQLWRGSGCDQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB19</accession>
    <name>A0A8H5CB19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB19"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="153" mass="17243" checksum="3C2A660303CEF958" modified="2022-01-19" version="1">MASISSRRLAKELAEIHSEGCPVGINLVKADDFTCWWFTIEVMGESLYQGDKFTLQFRFDPQYPISSPAVQFVVTEGRQAPIHPHVYSNGHICASILGNEWSPVLSVVAVCVTLQSMLASCKDKQRPVDNDRYVRHAPDNPKKTQFHYDDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBG3</accession>
    <name>A0A8H5CBG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_012224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBG3"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5338418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="363" mass="40933" checksum="46B8EA205793F1F7" modified="2022-01-19" version="1">MPELPEVQRAVNLIKRVGLGKRVQRVQTTEDALVFADITHTEFAGELQGRTIKDVQRYGKQFYLVLDGKGRLPVLHFGMTGILQVRGENPLFYKEAPRKNPSEWPPRFMKFILHLVSPDTNPQDPQIVTELAFSDPRRLGRIRLRDSPKTEPPISTLGFDPILSMPSLENFIPMVSKRSCPIKALLLDQSFSAGVGNWVADEILYHSRVHPEQRCNTLNATQLTTLHHQIKDVCQTAVSVDADDTKFPENWLFKHRWGKGKKTKSSLKLPSGEPATIKFITVGGRTSAYVSELQKHTVNNDEQQPFESESPSKKSTHGKRKVKPTVDEDNEGESDLTALSDEGLTPLPKRKASVFILMSEYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBI5</accession>
    <name>A0A8H5CBI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000210">
        <property type="protein sequence ID" value="KAF5337703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBI5"/>
    <dbReference type="OrthoDB" id="3261131at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71666" checksum="2E0FEB00756F7031" modified="2022-01-19" version="1">MSGSQSRTRRNPKPYAALNTLFLNEVNRKHQVKRIEDLPRQAVETDMCVDKLSPYIVKLAKNGFRFSVDSITLEFYKPKTPLKLDDAEEWAQQHLNQDLRAVATKLQPAKSLKTVFNPDDIGTDYVDLVVLGEALQDVPEKRDTVGELPTTFGPYKRYDDLSKNIKKLKPSSAAKSRERETFQKSLSTVVHDGTFAVNHGGTVALETIAQPIEIFYPPFRRISEALEDPNFQPGLDLLDVISTIVLKAGIIAQEDNYTETLRKPLMEVLEQYLGKVYTSGKHSADGLIIPLLFIDLKLAFSEGGCDPIVQAEYSVLQRWNEEELKPLREKCSCPTLILAGGGPNFVLLGAVWADRFIVQRLSDIICLAQASTSVDDHIYKAARFFSAIKLGINDLRAYYKDVRTRKMEPLQPNTPHPRFFPYPTKFKCRQSKETISFRYLNATDDDDSRNLVYLAQTQEPQPRKLIVKFSDRYGYEAHQLLADAKHAPELFYCGLLDGESDVLDSEKAKGRFRGGAGGLYTGPMRMIVMEYLEGKNALQTPREEWPPTAHAHVKATIDQLHEAGFVFGDLRLPNVIFADGDTKLIDFDWSGKEGDVFYPHGLSENAGWVEGVKSFRKIEKKHDLEMLEKHFPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CC49</accession>
    <name>A0A8H5CC49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000205">
        <property type="protein sequence ID" value="KAF5337822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CC49"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5337822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="544" mass="58043" checksum="807D600B3FABAAF3" modified="2022-01-19" version="1">MPDETSPLLGPGKSPQNNGIFPQNGSHVDEGRRQESAEEAPPTKSQKSLLAIVIPMALGTFLVAMDSTIVVASYASIGSELNQLSKTSWIATGYLLTLTSFQPLYGKLSDIFGRKACLLVAYCIFGLGSLFCGLSKTMDQLILSRALAGVGGGGMSTVVSIIMSDIVPLRSRGTWQGIINIVFATGSSVGAPLGGFLADTIGWRWAFLIQCPAIVLALLSVSFALHLPPTDSSDFKTKIKRIDFVGAITLVCSVFLFLFGLERGGNVSWSDKATIGTLSGSAALFLFFGFVEMEWASEPFAPKRIILNRSLIASYFVNFFGVASALTMLFHVSLYFQALGPMSPSRAGLLLVPSVIGGVIGSLSGGIIIQATGKYYWVTVLGYCLLVVGSSTITLFSGLVVRSIMVMCVGLTISGFGNGGGITTSLIALISNAGQADQAIATAVSYLFRSLGSVVGLAVGSTILQDTLRVTLHRTLTGHDVNEIVRHVKESLNYLDELDSETKAIVLSAYERSIRMTMFFCLSMAFCAAFASFFIKETELRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFL9</accession>
    <name>A0A8H5CFL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142727" checksum="45D8330F6DAA6586" modified="2022-01-19" version="1">MFSSLTRGFRGFSVSPGPDVVSGDSTQEISHNANSSLPSELLDGMGSLKLQEELLSHSSHSSLPAEGMGTLNMAMGALNIEDDNAMPGSFSPRIMNSANDQTSSSSRFDDDLVTLLTAATITATPADGSSHNKLFSSSCEAYQQASTSSRTYRPLEMSDVVEGLQAAVAARSPVSSPSRRPGRQFGSTAVYLPRRPSNQSPAGSPQPTTPNFLTPPASDPATTLRDQKEHLALENMSGRLAEHEDMMFGDAFSSLDAEQQDLKLELARTFLKSSLGEITQLLSNAHRRQKSAARRSSSDSASKVEQLNNQRKALHERLRSLSVKIAALDAFRVPKAPVRINADYVYNSDFPKLDQINQVLILLAVICNMVIGLSITQCNFLVGVVVLLVKLGMSTGGTHDSSISYSPTPSQNTIISDMPTSLADALKKFGVEGSFDMYAACPTCNFTNKATMLDNNGQSRYPETCANLVVGESGKSICGTGLLNRRSNGTAHPIKPYLVSSFHDYLARCLADPAYLGLSNKAADDAYEAINSGTACNDVQNVFEANFTSDFKGPDGSLFVNRGAKIRLAFSIHTDFLNPNGITHRGPTQSIGVISCANLALDPSIRYLPEYMYIAGIIPGPKEPNVDEMDHFVRPVIEKFATAWKPGLKVSRTAESELETAVETGIFLSTNDLPAARKVAGFQGINSEFICTVCRLRGREQVMNTNHSHWPTRDVNELRRLAEQYRDAQTVAQRKSLFKQHGVRWSSFWMLEYWDPTKMLVIDAMHCILEGIVHYHCRHVLRLDTSASKTKTDSENFKYVYDWPWVDYSDDLGPPGRTLEEKDVPCVAKVQQALCISLQGDKSLTLEGLWTRLYNKPNLNSLHFVVHNLGLSLALNDIREEVADLYLKRVTQKSKSKNPETRFPFHKEANTKSHLVAILINWRLKQPMHASHNLPVTSTHDTLAHIRHVIATTQTPSWVNSVPKNYGDADAGTLKADEWRTLSTIYLPIALVTLWGDEHSPPSQDPAVLQSVLDHTMWLFQAVMIVCRNTMTTDRADAFREFVDKWVNNLRKVHPHTREHAARPNIHAAGHIYDFLIRYGPILNWWCFPFERLVGTLQKINTSDHIGGIMESMIMKTLARTANIRRWLRRPECPEAVKQLKVLFDKCFVPANAPPPQEENHEMKGNFRAYAKHKGINFSGVHTHSGNSHIIYQPVGSPSAIAGQIEVIEDMSAERGTPILVHVRPFLPLVKPLSDPFLRYPHFQATTYSSQLSDEKDIIGLDRIISHAARFDYSYGRSVLVDLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ74</accession>
    <name>A0A8H5CJ74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000158">
        <property type="protein sequence ID" value="KAF5342739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ74"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5342739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11236" checksum="75AB99F9E78644B7" modified="2022-01-19" version="1">MLMVCAVDTLARETTGKKSVAIESFAKALRTIPAILAGNAGLDVTELVAELRAEHFEGRGDKGLDLTFSPTADVLCVLAVFHLFIAQLYVLISDSIVVSSLSSIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLQ0</accession>
    <name>A0A8H5CLQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLQ0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="462" mass="53691" checksum="CC77BB82C39CD4C3" modified="2022-01-19" version="1">MAHFTTDVKELMIEDWLDDENEVIGLPDSTVTSTRRKVGRVSFWHDLYDKAAKKLTHLTTLSITNSQITEVLVKGMAEMKNLRSLRIYECDAEMFWLPRHPRIAWISAERTIAFYEQWYRHALLVQERWAMFLPVLMRLEELHTDSWPITDMFLRTDPKLQYERMRVLRIGPMEITEKTWLFDNLDLVVPNITSLQLLVRYKDSVPLNHRRSFPINLSRFPLNLHRVQVPLPILKSSLLRPLTQLDWAGNQFNDSEPVPRTFFSEICGETMTVLSLPWRNFSHHDIQECFPKLRTLTIIVDTSLQELQAAANQRQLTGQEDLHHLRSGDVNVPLVLAESEAGAVLRLVTQPSSGRLLGWNLDAWHATITQALTDNQFPSLTRFEMVDRSLFVWHRDLGSASKDGWKPSIPHCNRRLARLYLVDETNLPVYYVDRNHCIQSLLDSTPDMFSTKIGRSIVSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN63</accession>
    <name>A0A8H5CN63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN63"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="161" mass="17720" checksum="6593542A47260EC1" modified="2022-01-19" version="1">MKRLSESKQTFDETCKNLIERMINTVPKNVTLTDVILPIQNKVGLSEFSTSTDPKEDDLVFTITLRTIDLPDDPNRTVTFFWTDRRASDSSSSCPSSGCLHSAPTTSELIVAAPTFINQGLPFLGYNAVVYSVNATINASTSIDKFWFEISEGQSTQAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPJ3</accession>
    <name>A0A8H5CPJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPJ3"/>
    <dbReference type="OrthoDB" id="3038673at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36378" checksum="268E89BBA6A03EDE" modified="2022-01-19" version="1">MNCRGLCPPCYSQLLQLQPTAVDPALSEFFNENSPVPDDEIPRILDILDSASAHEAFISAQYKQAQQVMDHLLQIRAKQSQFIARHTSMMSTFRRLPNEILGEVFQFCVVAEQKDDSKPYMPVVGKKGDIRWRLAAVCARWRRIICDGMPKFWASIGIDNASLMDSEKVHVDPLLCMSLVRSGSYPLSVEYNLFAGSWFRGVMPAVDRKCMELIWKESRRWQEITLVDFPLEEVLGTSSPHAHALLHNRLPLLRKLSIRPTISPQIPSQMTLPTPSYMRLTSNTFVYTTLRGLSSPFPFPNYSPMKQTMIYMASCLSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPX2</accession>
    <name>A0A8H5CPX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPX2"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="643" mass="72627" checksum="8E40B82F5F45EB21" modified="2022-01-19" version="1">MPAARSSKNDLDDEYTLADAQNRSMGTARQISANRNKSGDVEMDGLEEDYKLQKALKPPRATTYTAQALYEQIQSRDIDLEPEYQRDVVWTESKQIGLIDSILRNFYIPPIIFAVNAFDDGFETKTCIDGKQRLTSMFKFMDGLIPHRDPSTNEKFWYKRNPEAHQNSTRKVRLLPDQYRRLFANKQIVCVEYQDLTDANERDIFQRVQLGMALTPAEKLHVINTPRANFIRSLLSSYVEGHSLGDARYMPWERSRGSDFRCVAQAVFVMSKWGSNSLLGAGSLPQVERWLIERGKDDNTSKASAQKKKRGPGRPRKVKVMEQDDEIDEQEIDEKDNDGDYTDAPEVPETFARKVRETYEILGKLAETERLNQVFHLPHNPKVSPIEMICIATLIFVHGVNAKANARLSLEQLSNTIGEMRAKVRAVHKDIRMNDRVGKTMIEFIRNFKTPLPTLPSMPMQTDDDPMSVSVSGSAVFVDPSNKCKRESNSISHRDGEYNPPSSSPTKPTLKRKIAALEQTGSQSSVRQIPPPPPWATLPSRPDSPPSPRADRLSIRELHRRNSPPNPQRLPSPEQASAFSPFVAFQKHGQQQPASGAPTDREIKREAANSSLSSPTSSHPDFMMTQQVLGFQMMGIAPSHNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ68</accession>
    <name>A0A8H5CQ68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000106">
        <property type="protein sequence ID" value="KAF5346011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ68"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="312" mass="34618" checksum="B9F1689D375748AD" modified="2022-01-19" version="1">MRFRTLVDNVSTFSRIIQSVDKLQKKCIIKFTESSMHVICNHEANEGGIQVWSRIKISSLFSDYRIQSTANNEITMLLHAEALIGALRSASPNGGGIGGGGGNVGSLDTDEVIMKLAKKNDQAVLSFEIRGTSRQGKRMKVTQDVRIEVMKPETLRLNEPMCPEPDIHVILPPLVKIRTIVDRMKGMSDILTFQANHSGCMKLKIESDQANVETEWKGLAVPEMTRDNLASQPQTQELSQEVEKVKDPEELFSVDVSIKSFLKFLNSHVVSSTTIACICQKHCLILYVYIGDVADAGGVLTYYVPAIIDEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS98</accession>
    <name>A0A8H5CS98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_009950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS98"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5346118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38387" checksum="37D81F976A5170DE" modified="2022-01-19" version="1">MIYDLPPIKSLSDPFLNKIDDFNRRLSEVFYPGAHLVELFPILDYLPAWLAKWKRDAIKDFRFFSALFQKMFRVNKEQVVSGEEHRASFLRDYSREPREDGNFRLGVRMACRESPTYTMITWAIFAMIHFPEVQRRAQQQLDEVVGRSRIPSLADFKHLPYIRAIVQEARLMFLCLASLTLNNFRYLDGDLLLHLDQRIIQSRSDDYYEGYYIPKGTFCMPNIWSMNYDSEIYGPDAGDFKSDRYLDSCGNIKDENDEDHFSYGFGYRDCVGRHLANNALFIAVSMLLWSMKIEPGKDENGKNMLPDINSEEMDLYIYIKCDYPCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSE5</accession>
    <name>A0A8H5CSE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSE5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5347164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27856" checksum="DF3A8586A82A35D2" modified="2022-01-19" version="1">MSGKAHYERLPEESDGLLQGDEPVVAAKPHSKRPLWLVFAIGYFLVMVVHVTIFCFQVRQSILPKIFKPHYTYIDGDWPQELAVPESYGAMNEIQTAFNDTPQFVDIFSPDAHAHWETILPPGGRGYIKLGGHKELFGITMYHQLHCLVRLRAVIAGEKEDMAHVKHCFNYLRQGIVCNADITLEPGKTIIHTKADGTTYPSVIGGYDVDHKCRDATPVWNYLNEKWAQDFPEYDPMAHASEFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSM5</accession>
    <name>A0A8H5CSM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSM5"/>
    <dbReference type="OrthoDB" id="3221808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="42"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="963" mass="109207" checksum="A9D156481B0EEF6E" modified="2022-01-19" version="1">MPTTSAPSSQLEDLEKNENEPDTNCAGRFKPTADDDACFQLWNVYISQAHEYDKTLLEGWKKDMDGMLLFSALYSASLTALIVESYKKLQLDPADLTTSLLTTISLQLASSNGTTTTVGLLDTSFKPTTSSLICNMLWFLSLALALTCSLLATFVQQWTRDFLHKTTMRPSPVVQARVLAFSYFGLRRFGMHTFVDVIPILLHISLFLFFAGLVAFLLPVNLPLTILMACVLFIFMLVYSALTLHPLLFLDTPYRTPLSDFLWRIANGFAVRQHGLSDDDLSLTEAMVEKSLHRSPERDRRCMEFTMTLLTHDTELIPMFEAVSEALASSRASGVRHENFGIIAPLLQSSVPEINIISRIRNFISGSSTPGESTTKALKSCLHALNLLARLVINLPMENIETSRQYATFWFQRDLMAFLSSSPSLPQDYFISTIAMLRTSRVQGFRRCIERMAEVLSSRKACTEQLREVKSIFANLSREDIDWTSEKFTHHFAQLDSTLQNACMWGMTETDAAALVQQAQEHIAQLMDMSRWKAALISVLSRFLSEATDVGLVPVEMDLTFTLIHSSIPTLEVFDQSLDIEEDEAQATYLLQSASIYPESVPPQLFTLLIRLLFSTKRALHFPGAVESRLVLYKYLDNCTGGQRKLLVKSDSAYRLEKCISLDLSSDCAGDLLATWCISGVNDVYRGMGFPRSTVSPRLLSFAKEIFRLIPMASTNFTQNFWWFGMLTDTEQILCEDISDKLEYLPRGDDISNSLDISSFMGDIHALGQRLLPKTPVPECPLPCPLDVYQRWVSDIQDYVLSMHLLIITKYIHIVSEGASNNKVQDDWDGMVYLMQLHHGQIYETVQLQLANSVWKLVSLDPWTRRDKDSSQWDLFETIWNVSPHWCWVNDVESAKILAKAIQRHKDAPDFTGILYYEDVCLARCMTVIRKAEAVEQEEEDESKDEDKEEEEDESTDEDEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTN6</accession>
    <name>A0A8H5CTN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTN6"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29049" checksum="CE91A22215462947" modified="2022-01-19" version="1">MSNSNTNPLTGIEALVFDVFGTVVDWRNTVAREIKEVGRRVGVEVSEDDCYAFADEWRQGYIYNTRRIAEGGEGPKEVDVMHRQILDTMLSSSRWSQSGLGSSLDEGMKKDLNLIWHRLDGWPDSSQGLKSLKEHVIIVTLSNGNVRLLVDMAKHAKLPWDTIFSTALFDSYKPNPITYQSALSHLSLSSTPSKAAMVAAHIHDLRAAAKVGMKTIFVKRETEDSVEVRESVRAKSEGGEVDVVVDNLEELAGLFAARDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWS5</accession>
    <name>A0A8H5CWS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWS5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="32927" checksum="34627D9A1A4FDE8B" modified="2022-01-19" version="1">MGSIPPSVPLDLDELSLMFISVHGATLLPILVAGEAENADEDRVTLEDFSVLGFQGGCVFGEGYEAEVARYHTCELLLTDIGCFHSTGQRNSNQDASEEIWTLGLDPEAESQLSRSATLRLQKWELEKHLDSETIAADLRDQGTSSPRQRTVFVPDGKFVNEVGTWELETHWDSEAIATDLRDQATSSQVCQRKGLVPVVEKDTIIRERGKVSRRRYPASSCSQLPSTTFASKFVSRNQSLSSIPSLADLKPLTCPQRTLADSYTPPHFLTRISIHKVSIQISFNIAGLGFVSPIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0Z5</accession>
    <name>A0A8H5D0Z5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">D9758_007822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0Z5"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5350197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="296" mass="33088" checksum="CCC5A391D6DF206D" modified="2022-01-19" version="1">MFPTSLIRSTVNPAEIAHFSRLSALWWDEHGEFSFLHKMNPVRMQFIREKILEIARDEQPDLSGNNPDILNGLDVLDVGCGGGLLSESLARLGARTLGIDASESNVAIARHHSTLDPRLSQNLSYRHTPAESLLSEHKQFDVVCSMEVLEHVDNPALFLSTCAELLKPSGHLFLSTISRTPLAYLLTIFLAEKVLGKVADGTHTWSKYIKPSELIEFFHKYRSPSQHPEASRPWITRLYGDGVPTRTEAEVRGLVFNPLQAGWMLAPRGAWGATECNYIFWARKPALESALDSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D160</accession>
    <name>A0A8H5D160_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D160"/>
    <dbReference type="OrthoDB" id="3186354at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="343" mass="38021" checksum="AD04AED1A9896F40" modified="2022-01-19" version="1">MQIFTGSPYYKRMMCHLPFLPLLLSATCTLISLMLDSGVSNTQRAFGLAFHYLLYGIYSVLFLISVVLYVKGDKREGTRRGRQLRITINILLFVLATIAVVLDSITEGTVLHSNSTKSIDIIPSVVFPFLLILSSMFADTLWMYRCLVVWNHRIKIMILPILASVSIYLYLLIMACIAASREHIHNSATKEIYFEVAASYLIIACLNLLICGMIAGRIAWILHLPGPKVQSSTRKYYSKVIAIVLESGLLYPIVLLTNAGIMLRHMPLFVGIGSGVGMLIQFAGIVPALIIVRINLEPVPEPNIPQVSLSQVHDSELGTSILISQTITTSTMQISYPDAHVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DA61</accession>
    <name>A0A8H5DA61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DA61"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="488" mass="53545" checksum="117DFC066C693281" modified="2022-01-19" version="1">MNSNKPNPPSQSPTPSSGAQSSGSGPYTTSGQQSNAIAGSSAVGSQAYYDASGSTQPWKTGWSMTAAYPYSTTNTPPAYPHQYSYTHFRPQTYPTPTPSQPQTHPQLQATSTLPKPTIQSNKGKDKAKSPSPSPPPLEYVRYWDTAIKGFLEQLGMTQALRGFELDMLTLNEEYERSVVPDALEKLVKNLEALKNRNEQSEPMEVEEDKKSLEERKLEHVRFPPGTQPTLPSTINKSISSFLANKRAYNDASNRTEFLRSLAEKRASMPDPLETIASCARTDAKAVNRDVQMKYDVAKNEDGPLRRTVKLTLRPPAEPGASSSSSASVVVKGKGKAQNTKEAVAKPIVAVEDPLTAERYPGLDERLGNIESHLAVRFVPALPRSLLDRLKYLEEHIIRLEKEYPPWAALHFNQPNRGWPPPKSTPIIVPSHLTDSKKEPGSQNGSTAVTTPSGTAILPKGRKDSSLHRAILEKLEIQNAKNDLSTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F1A7</accession>
    <name>A0A8H5F1A7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000420">
        <property type="protein sequence ID" value="KAF5320024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F1A7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5320024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112820" checksum="B788BA2DDC0A2496" modified="2022-01-19" version="1">MFFQILLTSWTIYAPNYSSPTLRIWICRPLFNISSDIDWIEDHFSSSSSLRPTFSASRTPLTNYSHKIPVQSLCFKTLKTKSLTIGYPTKMTSGIYAEYIQAKVAKAIREALTDPHRTSFAKAGDDIFNKLELGKNTLKLCHAFKSPKRRESFRKYVRKTTNNYKGTLRSQLFETTLGKKKKGLHSAVIKLEATLKVTHNEAQRVKFTCRVALWRRYIRDIIANSTPTQTKRLRGDTEESSAAPEASSDTEESSSKLDSFWSGFDSWLAGLSKKMGSNIESAAWRRYLDETAKLDEKESSASIAAPALLASTSIFRAVTLPTTNTHPQPDNATTSFFEEQDKRMDTAGDIEELQVYEARMVAGNRTRHPLYSPTLSSHNSPHPGSSLSFGTRFHQPAARWNSGSVSSSRGHTSSPMYPFNDESFLSSPGPETSGAPPITSFLFSPSPNDSSIRNRPYGSGTREHHRSISGVSSSLSPPLSSPLSSSFSSSVSSSHAEGWSNGSTAASGAHSAGPLKLRLYKLQLNYGSTVGTRHLPLEPMRSLNPLPLISAFFLVLQASNNVFAASRALRARDAFTTFSDNSINEGENHDPLKAPDGSEIRSISIGTTGTTVPAYWSTGVENQMQEATQAFIVIHGKLRDGDNYWSIMQQALESAVQDNYPGVDSKAVVVAPQFFSERFNSGEYSNTDLAFLDVNAWQAGDVAVHPQGTKVTSMDAIDSLIQTFADKNQYPSMKSVIVVGHGGGGQLIARYAAVGIDPPDGISLRYIVGDPSTNAYFTTHRPVATTENNFNSSCDFSNVWRYGFDNFTGTTQLSAQEPFVYFQKYINRDIVFLIANDDTDVNGDQYCPALVQGGTARRDRNLAWWAYINTLARTPEPVQLLSNLVPEFAKNKNLPNWSNATRSSSFIGPKLIVVENAGHDPAQVLGGSEGRAALWNAMSDMPQGWRPDGWNDTTSDCGFCDGDQERRTQMSDMNSNTTTAGDNSSSGSASGSGGDNNGALGHGLKGALEVMLVVLAIVIIWTFLPRSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAM5</accession>
    <name>A0A8H5FAM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000342">
        <property type="protein sequence ID" value="KAF5329905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAM5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24218" checksum="8ACA62BDA83A84C0" modified="2022-01-19" version="1">MFATRTAAVRIMMVLTTAITLCNMYITGASVKDWLHSTRGAKKQFRTKLPILVNTAALRVEANDYYNIHSDQEWSSLFTPLPGYPFGFVQLESEEDGTKAFFEPAVYHQMHCLDILRQMIVHHDWSDRASEERAIWHVNHCLNMVRQAILCNADTTLEPSYIFDVVNGRNQSAASGLDVMHVCRDWSQIRSYVEENYRSTLAHGTSKENRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCJ8</accession>
    <name>A0A8H5FCJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000314">
        <property type="protein sequence ID" value="KAF5332065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCJ8"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="63968" checksum="3A575397CCA61F2F" modified="2022-01-19" version="1">MSSYSVPHESAKLLEHGIIHNPLHHGLKGSEPLPAEISETLPYVKYEGSDLPLIPINWRFAESLASLKGFQACMLNVLLKRKYGMDYQEIVINTNHAQLFFQSLLTIVVDPDGDAITNIMFDDVHIAKYFPVLEKNGAFIGAYNAFCTNIYRAGDGRYFHLHGDINPTKAQQALGLSPSLSVSNSNEARNIYAEKVSTFTGEELETLMNDKHGVSGTVCHSTEEYLSSEHGKANAHAGLYELFHIPNPKQPPTWWDAVDNRDADPRRPLFGLKVIDLTRIIAGATIGRELAELGASILRITSPNVTDISSINIDVGWGKWNAYLDLKKEEDREQLRGLMLESDVVIDGYRPHIMEKWGFGKDDVLRMCEGRKKGIVYAREDCYGWNGPYSGRSGWQQISDGACGVSLKFGRAMGVDEPVTPVFPNSDCCTGISGATGILHALIQRAEKGGSYVVDVALNYYSQWLVRSCGTYPVDVWDDLWTRYGKPVFHHDDNMQITIPAFLKMLKDKAPELYDESYFEKRHSVPLGVDLRVVKPILGFPGNRVSLGYNVGVRPNGVDEPRWPENLLSENIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDD2</accession>
    <name>A0A8H5FDD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDD2"/>
    <dbReference type="OrthoDB" id="2901006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="276" mass="29068" checksum="A92B46B6118F8308" modified="2022-01-19" version="1">MSFSPQHDAMHHRLPVAGRKDVAASRVHDRVVKTRSGDRRLQSFDSRNGNGNLTRDSSDSSDTGSAYAIELDSDLLTPQPLPPSGLATYISPLLLADSVDHNLIYVSGNTDTILRGKNTVVDDMDVYSNDPSGTGNGGTGGLGHVLQYKGNWGVLSPETNVDLLVSHNPSSSSTASSTSSINDGNITLSYTLDSNSPINLTLPLRSNSDTPIPLSKFLELEFNPLYSEQKVNGAIHTLEVMIAEIRYIGDDTSEGASGSGSGVDSASGSSSTPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FH64</accession>
    <name>A0A8H5FH64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000227">
        <property type="protein sequence ID" value="KAF5336626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FH64"/>
    <dbReference type="OrthoDB" id="3071729at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5336626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71272" checksum="993469F142270CBE" modified="2022-01-19" version="1">MPDTFIAHDPDTRRAVELDSRICVGHHPEDVDRKRAKFAVIAKDIAQLTQEIERVEKVLDNLKETRKNAVFQLKMGEALLAPISRLSKDVLAEVFEHYCREEVEDLPLIHAHPADIISSVCALWKEIAYITPTLWSYIHISGVANPFAKNPIDHEATRLTLARVLTLSRDAPLHILFSCDSTEWHKDRLNLELLHDLFKHSYRWSSADILIDSEINLVSKAFHFFFTASSASSQQCPFPLLQSLHLCIDKGDGIYISDPRATFVPTDGPSLPALRDFSVTCYSVAVPMPTSPLGRPSWRLLVDPALITSLEAVEQFHDKDLLVLGQFKSLQRLLLRNYQGIAQEPSGDLDERIVHLSSITHLVIRPHMYFGSTVTLTLFSRLSLPNLTSLEISQFGSCPDPLGIWSATGFAEMVEHSSCNLRSLFLDEIQINLEDLMDLLRLTPCLTHLTFCEYGEPDVETEVAAAIFSYLTWSTPGQNDGNLPKLTDIDLRTRSFLDHVLMGKICDLLESRMSGEVSTLKYFRFEPRLSSSPDIAGYTDPGPEVLRFEELVRGSLSRKAFFLVIPDFSGSTCSDSEQDSDSEVDSDSDLETYSFHSGSYYSDPPLAPHDDDRLDTNLPNYPTGSDVLLRSYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHW7</accession>
    <name>A0A8H5FHW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000205">
        <property type="protein sequence ID" value="KAF5337825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHW7"/>
    <dbReference type="OrthoDB" id="3349377at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="28917" checksum="A47E647A6925A3EC" modified="2022-01-19" version="1">MIAEIILQMRLYALYFLDRKVLVMMVATFIVTAASSAAIMGVVLSKITAFSVPIPVIGSFCVPTRIPNWFYTFWIPILTFETVLCALVLMKGVQTFRASGSPFQSGRKLVGILIRDSVVYYLVMLATYLTCLLVWVIGTTDMLEIPIGFSIAMSCVLGNRVILNVRLANREIEESKVAATSSNHPPGFDQQHSHAQSWITQAGSRISQGAASILKSASRSEHGKQIDYDDHVIDTLTDMEMAQLRTMQAHTPVHASDGFIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FID5</accession>
    <name>A0A8H5FID5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_013112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FID5"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034695000" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5337916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="420" mass="46073" checksum="702967646BD072ED" modified="2022-01-19" version="1">MVFTQLLFLLAGILGLSQVIAASRDCVVRPLGQGKDDTDQVEAAIAQCGHSGTTTFQPGTYNITRKMTWDLHSAKVDLHGFLSFIPDIEFWLNPDNTFRVVFIQSQASWFVITGSDFEIDAHNTGGVQGNGQVWWDFFTNHTREDGDGRPIAFTLNNVTNGVVRNFRIESQPFWCNTVSHSRNVVYDGMYCNASNSNPKFFGQNIVPNTDGINTYVSDNVTLLNWDITCGDDCLAVKGNTTNLFVRNVTCHGGNGIAFGSLGQYANLSDIVENVHMEDLKMVRIDKNIQPNMGNAVYFKTWTGSVNGQPPTGGGGGTGRVHNVTIQNVVYDQVNEPLHMYQTNGGHSQDLPSTLMYSDLTFSNWSGTFLTNTVVDIECSPAVGCDDITFNNFTFTSLSAGALKFICKNVENLTGLNATCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLQ4</accession>
    <name>A0A8H5FLQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLQ4"/>
    <dbReference type="OrthoDB" id="3236720at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034739413" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="21277" checksum="237560D477235F65" modified="2022-01-19" version="1">MFSKIALAFGFVAALAGSTLAAPLNRRSVHSFDNWGGFSSLSGFDNFYGSDNFCGVIQDQTIVEQQDVLVCHSVSIEIVQQRLLILQEMAKRIITEQICEVETQTVVFHQFLASSSRFSSDLLHISGHHAGYDSAIVGHFGDLIDESGSLTTTDFGFSGHDAGHNTVIVGGTNWNDATSPFSVRNAYNAAEMAVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FM19</accession>
    <name>A0A8H5FM19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FM19"/>
    <dbReference type="OrthoDB" id="3251353at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="215" mass="24224" checksum="15149FB81699D951" modified="2022-01-19" version="1">MSSTTPYRDYFRRRTIGRAASPPTWACYEQIPYDDEDDYSDSGSESCSEDDEDYCHAAAAHEGPSDSDEEPLPPHSGNTDGAHDLDNMDMDMGDEDHGVDAEKNASAQTDIKGKQRAVDPAPEPEPPKRSHRRRQRRTMYTLRPILTIQRSQGFVWNQDLFIPPYIKDRYLASTSPPNSGFMPSSVSSTNSALNEYEVEVVEIRVQEGELQHIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN76</accession>
    <name>A0A8H5FN76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5343001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN76"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18611" checksum="77DBB5CC63B43C90" modified="2022-01-19" version="1">MYMSHRSTFTKLVAEGSFPFRVVRIDGFMGDKQLLVFDPKAMHHILVKDAVLYEKTNLTMSALIMGKRLIGNTGEPHRKQRKMLNPVFSIAHMRNVLPIFYNVVDKLENGLSAKLQNDASHGPQEIEMLSCMSRTALELIGQAGLGYSFDDLSTEATAHPYPATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNI9</accession>
    <name>A0A8H5FNI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1406" mass="161714" checksum="98CCC2B167416671" modified="2022-01-19" version="1">MPPRLRGGRPVGQRRPPSPEPYHLCTCDVCSLQTFWDSEGIARSGRLFYSPRALVQHKREYAENMALSSFNDLTPPEPVIPEIPIAAIPFPLSVNTRRTESQVAANNSASASVCDGSQVGVEGLEQVPDGLTPGRDEAESQPPRDWIKVQEIRRHLMARKQASVLDPTSFEFYPRPAAGMELPEAPCLRENYQGNSYVLGHLLWLEGCQKWLEDSDQRSPCWGITEFRLEHQCATRSILDEIQSTRGMIVNEWKRQRDIATRGQERIVSVDPVLDYTESTYVFMLYGLLCSVLHLIAHVSLDYMSFVLGCLRLTATLHGTDPVEIDSNLPRDMRTVVNRFNLVPQSTEFVCCPRCFKLYPLKTYPEFCDGARSAAPLGTKCQRRLRSKEPPLPRARKQPVRTFQYNDIRQWIASLYSRKDLAPHLGRRFDPTERKSIKEDIWDADLLQDFKGPDGRLFFGPDVVNEDRLLFSLNFDSFNPYGNRQAGKKASTGGIYLICLNLPPSIRFKTENIFLAGIVPGPKEPSYHEINYFLKPLVDDLVLLWRTGIYINKTSQHRWGRSVKGALGPLVCDLPAARLVSGFAPHNADDFMCSICTNKSRNNLNTSSWVARDIEHHREVAAQWLECQTSEERDTIFLQNGIRWSELLNLPYWDPIRFTVIDSMHCFYLRILQRHCRELWGMDVELEDGDGLWEVVDPSDEDKELGHRTLRYGSASALGSLSTHVLRYLALQHNLEHRENKKVLFARLKDLRVTKGWFSSKQELVYSETLDQDGVSMIGEVTTEGQSSNARQTLTLEEQKKSLDEARRAYRVGRTKGDLKFFYVDTLRELAKEEAIANFKDMLKDDLVTHLHSKRDKARKDEINRHVQNALEVPPEQEYKRMLEEASRTTIDKAHEDKLKGLILYIQPLIEAKRRSERNFTGRDEEDENDKSGAEEDEVTSQGNGDNRDDGVESELDSDSEEIEEIMKDKVKMKEYIHRQRRLLNITNDKDKVIKKTGKRKKPKTAVLGKERLAEIREDMVKLKLPSWMSIAPSNPGGTSHGKFSADQWRAFCTINLPITLVRLWGSESKDSRQHRMLVNFMHLVTATRLANMRTLTEERITKYEDHMHTYLKGIRQLFPEKKITAYQHMSLHFGSMLRRFGPVHSWRCFPFERYNYLIQNTPTNGRLGDLEKTFFDRFCMVQKLRRLLDEQTLPELLKPAGRLFNSIFDSDIRGTRIGDTLAFDAYFRGVEESTDWTGRNLTHLDPRTQAKLENWIDEGAYFIRGLLEKDKVQRLDVTFSTEKVAFADAQVVFKDLKLLSGWAAGSINRIFSARWRTVEGEVISRTFATIKPYIPLSTSDAKHDIHRQFGFAGGRLFYEDTDLEEVLLPVTMITAHFGYSAMQIAGIKRKTIHVLPQNKEFEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPF7</accession>
    <name>A0A8H5FPF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_012320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPF7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5344291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="632" mass="69433" checksum="B7587A917211742D" modified="2022-01-19" version="1">MTTSLNRASGSGSYSASSRAASSLQRGRACGNCRKRKIKCDGQRPMCGQCVKSARPGDTCEYADAGRTRAQMLEENISRLEARIRELEEPLDENSVKLHSPYVQIQGRSSSWPASVVASTEAISPIASTSASPSPPPSSSSHSEAAFQEEPPADVVRLLLQSFLPHSMEFGFFLNIARFRDSALLPLPLGHYARPAPALLSTVYLLGMHLLAGSSKTDSHNYGAQENAFLSRALLHVANVLSSSHPHRILHGIQSEILLSTYFFRAGRILEGKYHLTAATSLTLGAGFHRIRSGNAGISSSLNLLSVATPFLPAPADHIEEGERINAFWTTFALCNTWTVAIGSPLSSVVFESHGSKIDTPWPLDMHQYEQVEFNFLSQNVQWRSWVKVQEAYGQTILPFQERLPQDLRGSSTVQNFLNQQPSLQSEYSTQAMYAKASILLDRADTVAALFRANVEPEERSHLIQTFTSLDPLIDNFRSTLFTVLPMSRTPTSSPFFGTVLLTHTLAYSATINLHSPFVNDDHRSRSKSLKAAEGCVELLRQVDMGSIEQVNPLLGCLWTGVCKVLIDEISRVKAVGAGWASPASGSSREENELVEMLEKVFATMAVFSIESPLMGYQLAKIQETYQDSTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPM6</accession>
    <name>A0A8H5FPM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPM6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="216" mass="23694" checksum="2C1E78A1B20F4123" modified="2022-01-19" version="1">MKKTLQKARLPECNASDKRVGADERHRSGKRIGIEIRLDSNKNAPTRLSIVPQPTMSFGGRSTPPPRAPSPPITLNPLPIRRLHSARSCDSFADRGRPQLRKAKSARSIQKSPHSPPSRSGRYRSPPPSPTTQHPPPPVPPLPRAVPIPVPEKDPQPVLRTPIMIPTIRVPDTPVSPVLPSNKFRKQKSSGRRSSLILRFFTDRNSSSSPPSACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQV8</accession>
    <name>A0A8H5FQV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQV8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5345358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="438" mass="49688" checksum="9B6DA8D875651FE7" modified="2022-01-19" version="1">MQLQRHSFTALNSTFVVDSEYQFVKELGQGAYGCVVAARHRRTGDGCAIKKITNINTKRILTKRCLREIRLLHHFRGHKNITCLYDMDIVFRPDGNFDEVYLYEELMEADLHAIIRSGQPLTDAHFQSFIYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGYTPGSGTSKAAGNQGFMTEYVATRWYRAPEIMLSFANYTTAIDVWSVGCILAELLGGKPIYKGRDYVDQLNQILHYLGTPSEDTLRRVGSPRAQDYIRSLPIKPRVPFSTLYPTANPLAIDLLSQMLCFDPAKRMSCEQALNHSYLQVWHDPADEPVCESKFDFGFEEEDSIEGMKKLIVEEVNQFRAEVRAQARAASQIRRQESLPIPSREEILNSPMRGQEETTSGYTQNPQGQRPPSPIMDDPSEMLERELAGTHLGQGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTD5</accession>
    <name>A0A8H5FTD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTD5"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5348344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="21491" checksum="BD74C1986A8A69AD" modified="2022-01-19" version="1">MIRFDNVPPEIMQAMCTPMHQVLPSTPITVPSRSSSSMTTVQSGSLYIGSISAIYDIDLLRSHNVSHLVQVLDAPWLPPLGEKEGFTSFKISILDATSADLKPHLEEACTSIDKALREGRSVLVHCQQGISRSAAVVIAYLIRNHGMSYDAAYTHVRRQRPCIKPNSGFVNVLREWETTWRRPVLSQRRFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUA8</accession>
    <name>A0A8H5FUA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUA8"/>
    <dbReference type="OrthoDB" id="3039972at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="406" mass="43614" checksum="623D6502D59507E4" modified="2022-01-19" version="1">MLACSSRLLQPICLVLLSFFVSIPWWYSFPAERIHVEMKGSVGNDLGKTFRSLVLGSVVTVAIEFLLYGGYAILFGVFVHIIIHRQSAKRKLKLALMSSLFALATIVTILFVAEVATHLTFHFDCLKNHRNHTDSNGGAGAGAGGGGGGGGGGGGGNGNPGNSCNDIDPLDTWDGDTGKIKLATTIFFMLTNLLGDGVLIYRAYYIWNESIRVTYIPIFASVVNHILATIGLAQGNATTNAAAVMFSLWELYLALNVVVNVFLTLLIAGRVWYIRRQAELILGGALRERYGTVITACIESGVLYPIALVIFLSLELGLSSLDFLPILVQVMGIAPTLITVRSSMGISVENVEQVIARSSNVPLGAVVLRQRPGSTRSVDSTMVDGQMPTKKEGYLVGEGKEVQETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW82</accession>
    <name>A0A8H5FW82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW82"/>
    <dbReference type="OrthoDB" id="2150628at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="91299" checksum="ACA032BC25C96B89" modified="2022-01-19" version="1">MSAMRRAAAFDSRGKTRTVHHYNVHNAPAARILHTMCSSVNSAVLNMRRPGVDHSYSCYKTRFRYLTHQCSALAPAARPSPLILQERMPSDSNKLRKAPSKLPNRQTVVSMHWLFRSNIPSKRASYIQPDVRKRNFFGMGEIVGVLTNPAETVRSLTESKRLLEEARKEINESRERAQIRPKHTFSKLPGFFARQPEIEAVERVLEGEPTFTVLFGASSVGKTALLREVLTQPSYHVLHFDLRIAGFADLASLYMSLSKQMEQYFEEIANQMEGYEEFEKEAWSFKHDRLNVERRISEVSTDSGLSAVKTSDIARLMELFQSSLLKYWEFEPDTENTEGNQQKSKHQRAQQSSGDSNSDSTRVNPDANGHNGSFSKKSWRFRSVLGMKGKKKQQQPPRTLGNLQRSDDAQGQGEDGEKMKTKPMKKMPVIFFDEAHKLPALIQSTEAMSCLLSTFLVLTKQDRLCHVIHATSDPFYHTWLRQLNIMQHCKILTIGDCTKAETRAFFRERLLPRVPEPLKHRLQFEALYEAFGGKLVHWQDYITDYVNANGALDVKRSSHFLQAHALLNLHVIHSSQSPEGGEPSARNTGSNQDAQPSPSTSSGFKIYSPISHGAGADRMNSDEERCNAMVAGYYSSDFTAMQLLKVMNRINQPNVTFLPYFMLCREFGVRAIDGMVKGRIFDLRWTETVTRENAEEPFELPRPMSLGALQAMGAGGSGVGLGLSGSEEGDMVAVSEREFTMQQEQAQAQRDREREQDPYESVMDVVGPKLVPTTPIMRYAIREVLAEYAVQDSGSDSDYASLTDVDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWB8</accession>
    <name>A0A8H5FWB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWB8"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF418">
        <property type="entry name" value="SI:CH73-221F6.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5352165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="580" mass="65794" checksum="0444CF27B83F0CC1" modified="2022-01-19" version="1">MKFRDLRSLEEHFRGTPAQKHPKCPRCQSGFLDVKALEVHFEHKHPKIVCCGVRIYNDGPGLEEHYRNSPERKHPNCNRCGRQFFNWEALSEVSLDAFSPALETRRTDLRLITIIQHLLKHPATVSFGSFGGVDEESEEAEEHYILGDVEYPETISSDPLSGTVEEGLEQHLHPATVSFGSFGGVDEESEEAEEHHILGDIEHPETLSSDPLPSMVEKRLEVHSNHESLPGASGSSNTMPSREGLQTGDRGSLRYKESESISEHLHLTQNPAVSSRSFQLAEDQDFHRTDSGPSDPATSISSSSGYLSFENSDSETLEDDQLEDQSETLRDDSDTLLSVSLPTHPFSTKTTCGVRCDRCAREFSNPDSLKDHWFLSTDHPKCWRCVQGFNDDADLQKHLQHTDHGTIRTSQQYNSEADNVNEPGACGVVNEPWLNAVESTVHHHDANDHDLSCPRCRRQFFGWECLSEHFRSEHPVTVCFQCGAVMYENELEAHFQSSVLHPKCPCCKRGFYNSNALKEHFKTEHYKIECRCGLVIYKEEMQRHFQLSLRHPKCPRCHEGFLDLNLLNKTYINRLSVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZD9</accession>
    <name>A0A8H5FZD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZD9"/>
    <dbReference type="OrthoDB" id="3123973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="38927" checksum="7EEA54C0D8252051" modified="2022-01-19" version="1">MSWSSFPTHALLDSLLLNLSLKFLPYSLAQIFLLSFFSLIQHTLSQQIKVPITATHGSPVTVTVFNDIGLEEYALYLVQDRSIEAFSVFTTITPDTGVGAQTVVFPAPTPGEFRIVMDEPASASITAVPTGAGSSEEFEVVSGPDGDADSDTSLSSSNSISQVPGTTESSHQVLTGTTTRIGTATTTVQGDGDEVTTFTVVASPGPNLQPQSISIPGLVGGLVGGLIAITLIALLVWRRRRRPRISITPPDIVPYNYSPDQRRYVSKLNPFSRKADPKSALSNNPHTGRGSKRPSDQDMTLDLETGLNDSLGSRTEKDAPRRVSRTLIHTDSGWRDTGNRNFNDVDEVVSSFSEVPPSYTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0E2</accession>
    <name>A0A8H5G0E2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0E2"/>
    <dbReference type="OrthoDB" id="3050033at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="655" mass="74973" checksum="A0A8154A144DFD3B" modified="2022-01-19" version="1">MNQELFSGLHSPSSLHVWRHARRNVMGLPSCPPDLNEFQYAILAFDRACHITAMQACGRENCENVLWAGRVRCCRNYCHTELLVPISDLKDRYEGSEGQASSRSMIKLLSPIIEYLPYARQQMGAKGRGRPWQHTKQSEPLFSALYFDQVFFEYEDIIAEKDESLLKPWAVSVMDRTKEFMKHVALCEAWHEMHLEKQAQQVEKRKQERKKDIEKRLTAIGWGPEVERARAPQTFFSTHRLVRLPTPLTDEEWENILPKFVDMMEAEKERWEENLCKESLVDRCKTTQDAYKQYVAAQTPIPGVVWPPLADVIQTGIFSGLLVKTPLTEPLQENEFTAILAAKVDPSFAQTWAKAKKAEVQALIQRTITKVKPESADILDLACAVMECNRCRNMLWYPDVLEHSCLFSNQSYYSYWGEEKPMDEVLAEFDPCVVLRICRWNQYECLSVWKIGSRNIQSLIKTCGASPSTTTLNELDELNPIIKCMHTYASWSGADVECKSTDLKWRDALLHYRLHHIYRDVDKTGLKCVVQSFTRPGQGTGKGSMQAASALNHESMDDQLTNNDVKVKSEQTLKDIDGHEDKQVTLSESTEDGVKIKAEQDHQVNTPIKDSDEVKSEQRDQTTSSTKDCVEVRSEKDDQATSPTMDNVKVKVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G2S4</accession>
    <name>A0A8H5G2S4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G2S4"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="202"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="938"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="980" mass="108291" checksum="7E0CF576442780E6" modified="2022-01-19" version="1">MNPLTRNVGLRVGPIVLETLVKHYFERIKEGIQTSAKEVTAKDGKEGDSEDLVQLRQDELLYDEAFNIIKAFLAAAALHTVEELQNFSNTRTPSPPWVHVIRLVVPMSSCDEAAVHLTKALGGEDVARKVVGGVKWWQIRAVSGVDAEWITAKKDWQDAKKRHKMQEKMKQENGDSEIYPEDSANDGSAQDYEQDMDRMRCILYLHGGGYYFGSVDQERYSIQRYARKINGRVFAINYRLAPQYPFPCAIQDALAAYLYLIRPPPDAQHKPIKPSHIVVAGDSAGGGLSLALLQVLRDSDLPLPAGGVLISPWCDLTHSFPSIHINTATDVIPQYGLSLHKPSPLWPPPSDEITVRIRSGLRHRIRHTLGKVHHDHPSSLKLPQQSSSASIPPSPTASLMPVDVGTTTPFPSVDPNAEPLENQNNQKVSLTASNGEVLTVEQQVQFYTLNNLVTHPLVSPALSYLGGLPPLLFIASDKEVLRDEIIYTAHKAANPEKFPIKNEVRAMYPALNEIESRYGPTPVHLQVYDDTAHVLPVLFSFTTPAKFCFRAIASFCKYVTGMSNTPSVSESKSSLSSGSGVSRGSTVKIIRSIKSKSSLRGKGSIFTSPEHKRSQDSTGDPNRSPASKSLTRSISDNFRSIAQKRSLSRTRSPPPGQGDIPPLPPLPLTDSPLTTPLVNESTSVSSVMNTSISDGNTEVTIPSESADSKDLTGDDVVSTMPNLGEPARTSSPTQVCRLAGDPVIYSETAEFPSMRTAMIRERVSTRGVVRPLEPEEELNAMKVPPELIGELSELAVRRYIDGLNKYNKKFSSTFKHIEKHRRRNYEKAQKDTIKNMSILQHSLDREVQQKREAEQNGTRDVATPDQHQLKDGLLASSGWIWSWALDDKERPPPSSIVSRRDVDEALRLARIADLSNDGSTMSGNNLWGIVNNFLTPGSKKDAMHGMKEDLKEKAETKASPPRRSLFPRVVSGKSSRRAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3B4</accession>
    <name>A0A8H5G3B4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3B4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="310" mass="34507" checksum="48A649383FFACDDC" modified="2022-01-19" version="1">MGFGFGTPQRVEVDSGARMENATLPLTDFICCSTYASRFCLPPGVGPGCECAGAVTGIERQSEARETWRHHRDTRLPPELTGSSDYGGGVSGKGVRWDVVDVFCVGRLAVDSKLVKRLGIQSGAPIDRYVPVVLFMEDWQISSRNLRATHAADGYKLGKPKKTFLPSTFRFTPSDNLLKGGRPNTAYDMLDSSPSSNWKQPLYAPSVKKCTPPDSPSFRNSRSTLVDGLARGTFNDSPCPFPLHNVVPQPLPDYTLWVALQIEWLDQLTQNRPFAQLDLCNLFCEWKIRFLRVPMGSKVNEKLQIRFAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3C1</accession>
    <name>A0A8H5G3C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_007541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3C1"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5357649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="46308" checksum="D5685CED2590B96D" modified="2022-01-19" version="1">MLSKRIIAIARGRASLNSRTALSMSRGWETASVRVRKAKFHSTNLLQAETVKVPQMAESITEGTLKTWVKKVGDSVNVDEEVATIETDKIDVSVNAPTSGTIKELLANEEDTVTVGQDLFVLEPGEGGASSQKSEPDSSKESESEKPAPPPTESSKAPESKPEPKKEEPKKEAAPKKDSKSSESSKPPAPAVGNRNETRVKMNRMRQRIAERLKESQNAAASLTTFNEIDMSSLIDMRKRYKDSILKEHDVKLGYMSAFAKACCLALKEIPAANASIEGDEIVYRDYVDLSVAVATPKGLVTPVVRNAEGMNFVDVEKEIAALGKKARDNKLTLEDMAGGTFTISNGGVFGSLYGTPIINLPQSAVLGMHAIKDRPVVVDGQIVIRPIMVVALTYDHRLLDGREAVTFLVKVKEYLEDPRKMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5K9</accession>
    <name>A0A8H5G5K9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5K9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="111" mass="12415" checksum="E97131F5F4C9EFF0" modified="2022-01-19" version="1">MLRMKRTCYTALMALATLRPRATLHSMVVSLLSPGVSSTMVHEAIKNVAGRERKKAELRTDDEVHGSLGNRDIDVRPPSDMHYHLSSLALPTGTELWHLFSSAQSLGQFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Z0</accession>
    <name>A0A8H5G7Z0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Z0"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034230026" evidence="1">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="135" mass="14434" checksum="31AC40C9549A15A6" modified="2022-01-19" version="1">MVIFVIIQLILLTRGLSYLAVGCLNISGVNIEVIGVLFATIWSAQVRGTGGGVVIYAGREVSQETMTHDIQFRSTRTRSTHTDLESGLHQQTSTHGTIATDLGSSDVGTSVMKERMDSSSELHAKEGAVVVVNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G836</accession>
    <name>A0A8H5G836_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G836"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5360078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62790" checksum="DFCEB3DC844AE4C6" modified="2022-01-19" version="1">MEDLTRTVTLMSKSSASLLLYSVAVASFSYAVIHFVRSYIGPPMPYPYPPGPPSPSFILGHFGKLPMKKPWLAYMEMAKTYGDVIYFRSLKEHIVILNSLDAANDVLEKQARFTSDRPFSHAPSDLSLIAGYSVGWNDVVSLMGYSDRWRQARRTSHQNLRPEAALKYRVIQVEKVHQFLQCLISSPSSEEIFRLIGALSQAIMMSAIYGLNLEITSESNQDDIAQAAKEVADFSDRIQLPGGNTYKSVPFIHYLPSIFPFLPFSRMENSAKTTLKALKDGPFEASMKAWTSGSSSSLVGQLVSEAKNRYPDEGKSEYLAEIESIKSMGFTALAAASDTTVSATTTFFIAMSLYPQVQKKAQAELDRVLGFGRLPGFGDRTSLPYIEAIYKEVMRWHPAIPIGVPHKTTEDIFYKGYFIPKGSGVSANIWAMGHNPAEHENPDEFIPERHLQDNGLGEPELKSGFGNVSNILAYGFGRRVCVGRYFADATLWLTMACVLATMNISRDSTNSANESVSDEDLKKNLEDYYTDCSLSHLKELPGVKVLPRLSKEELEGLFDQDKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8E1</accession>
    <name>A0A8H5G8E1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_011356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8E1"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034777150" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="32"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5360191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="553" mass="57276" checksum="468BB47A7AB4A910" modified="2022-01-19" version="1">MHSFSLLTSNLLLFFACSSLLIHDSSNFASASPVPDILASSGLKARKVPGGYSIPLQRTKRSSGRINDGRNSKSIGGNRKRGGIVAETGLGDHFDFQYTVPVEVGGTVTAVVLDTGSSDLWVTSDACTPTSCGGPPTTEQYPMSTFNDSGASVFIPYGSGSASGPVGFDTVTVAGISIQNQPFIAVNATDIAPQDTSGILGLSFPTLSSVQQELTSKSTLTESDDSILGTDQYGPVLARIAMTGALDTPMFAIQLQRTQIDIGGQGVLTVGTLPEGIDNSSLTWVPVKFYTDSEIGTQWEIDIDGVFLDGQRLADSAIPADGVSVTTTRALIDSGNSILLGPADVVDNILSTVSTTYNPSIGPDAAFPCDVPHTLTFQIGGKMFPVDPRDFISEKSTDLSTCLASTMFKASDPPSLGDLTSWSLGDPFFKSNLVAFYYGNLTHPSVDPPRIGFLSTVPQNANELLTSAIHDAESAGEVASTDDVAPTASAATADRITVSPGFSSPTATGPGGDTSKSDEGDPGNENGAIAGAKMGIGFVSVYIAVGMGMVAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G9X6</accession>
    <name>A0A8H5G9X6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G9X6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="603"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5361127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="783" mass="85334" checksum="6220E97F97E1173E" modified="2022-01-19" version="1">MDLGSLVNSSPLGNGTKEEEWGRVLICGGTDWMRLGRKDRSGAPKAESDLSPDLLEPHILRSLADIRVRSIHTSCSSCHFVVIDTNSSPSGGGSNSAWLFGRNGNCCLGVEGVDCISENAPMRLKPTDLGAKPGTRFVDAACGRNHTLLVGSDGHVWSAGANAYGQCGHYPCPEIPNFKLVQGLQHDGVPERAVKVSAGVTFSLVLTESGKIFAFGSAEKGQLGNGSTGERITTGNKTAFDIVYEPRYIKELDGKKIKMIASGQQHSVALDEEGCTWCLVKVNNRVLRAEVVVVCVLSKESESWKAWRRRRSMLCVLVVHVWGYNGYCRLGLGNQVDALKPKPVPQFTPPTSCATFVAAGPTNTVVIDRQGMYWMAGKWKNSGDGSSGSPYTTFRVMQDIMWVFVLCSLRHHFVAFSSASASSCRFVASSADAFLPSFRSRGCKITHAACGGVTHWATTPDDDGTTMTVAWGQNAANVSRRLWITLDSGWITCCFPSCFTYNSLGLPAFFYTRITYYIFALGELGLGPEEPKSSTKPNKHEPLDQIEVTQIAAAQNTTLFLVKIPLAPYTPGVSISDPSEFDQKKMEKYQDLPRHPFELDDTPELCMVCRKDNGEDDSPLECDKCDNPYHLGCLKPKVPAIPPGEWFCPDCSKQPGRALPGYTPTVPPTAGGSSSSSKPTHASSATPQPRKRKGEDMDVDRPENGVDGEDESERVGVEKEFFFEKTLVELNTAWDVFQESCLGDDIVLSSLGFSLGHGMSKWGVNECLRCRTSLLLLHQNMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAF6</accession>
    <name>A0A8H5GAF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAF6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="161"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="415"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5361181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="70191" checksum="990A93331EB60D59" modified="2022-01-19" version="1">MYRLVPVPGESSFMGFPISCFNFLLAGVQEIWWNITYVDDANPDGLFERRVIGVNNTWPPPPMDVNTTDSLLVHVTNSIDKPTTLHHHGMFFNSTSWMDGAEGVTECGIPPGESFDYVVPINSSGQWGTYWVHAHASGQYVDGLRAPVVIHPPKEVHSYDEEFTVILGDWYHDEHSVLLNKFISIANPGGAEPVPDSGLIYFAQNASYLPPISGTSPSSVTSAVGFNENATLPFEPGKTYRLRVVNTSGFAMFFFWIDGHDMRIIEVDGTDVEEFPIDMISVTVAQRYSILVTARNDTSSNWAIHANMDTDMFDTVPDALNPNVTSSITYSSSASVTDNGFVDEYSTVEDTLLVPSDKINPPPSTQTVELEVLFDTMDDGTNHAMFNGITFNSPLVPSVFSELSLGSNASVASAYGPTAFVLNHMDVVDIVIKNGDAGKHPFHIHGHKPFLVGRATDYTSDDPTLNPPISDNQTNPVRRDTVHIPSMGSATLRVVADNPGVWLLHCHIEWHLEAGLAVQFVEAPLEAQQQASRVPQVMYDHCQTLGKPISGNAAGHASTTDLSGWRLGPYQQQLGWHAKGIWAMTGCVLTAVLGMVTVIWYAMGGSISEEEMEHEVKEELDRKARLKGKLFGVFQSGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDE7</accession>
    <name>A0A8H5GDE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phytochrome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_007118</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="716"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1434"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="502"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1403"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1408"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5362908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1607" mass="174616" checksum="30FAEA2B9C43FDF3" modified="2022-01-19" version="1">MPDPPQSPSAPLSSPPAFVYPIKSLLTGIQPARDNDSNRPGPSFSSSPSTTPLVSPELYKSNTLDIAGKAGPSSDSDVNDVRVTVANKSMSHGRNLSQTLGSSSFNQSRSRRSHSMASNPYHQSLRSPKPRQRHEDSGVNFSHFPFGDSVDATTSFTRHGPSRSLANSPEERDVEPLTLNALTPTSFESLADPNASPSLEYNVRHPPALPLVASQAFHATSASLLPQEYSPPLPWNPSELGLVHLPSALSSNGSGSHSSSSTADFEQVSDHESDDDASENSNYFTPEELLSDSSGKKAQSLSVSEVDVSFVTVRFEHVQDENGHHVLTGREGKLERCEDEPIRTPGAVQGFGVLIAVEEQEDTLVVRQVSENATELLGLSPQYLFSLECFTDTLPGGQAGLLWDNIQFLPELPCSIAKPEDVKNEATTEDDFAPHVFLLSGYGAPGSALPDDYLPSYKGKRFWTCWCAVHRTQPSPYKTASEASPTGKSLIVLEFELETDVLNPLYPPPGTAPAAPGEDSPMSDGSNTDSTESSTDSTGTNSGGESGGGGNATDESEKTLVSGPMDSTTSLNIIWETPSSPDVVSDSEITPPATSSSTSTLQPEAHGRGTSVTTPSSLQGLAGDQNWVPSSEDIIESTTSRAKPLAALERLRRMSRLPTATPADSPSSNFASGTAPRSRRASRRSAASSQIPGSVGMMDVFAVMAQINEQLGGAPDLDAFLKVVVGVIKDLTQFHRVLVYQFDELWNGQTVAELVDWSQTHDLYKGLHFPASDIPAQARELYKINKVRILYDRDQSTARIVVRNKEDLENPLNMTHCYLRAMNLANMGVRASMSVSIMAFGSLWGLVACHSYGPHGMRVSFPVRQMLRLLSQSISRNIERLSYAQRLHTRKLINTISSDNHPTGYIVSNADDLLGLFDADFGILVIGDGAKILGPNQHGQEILIMAEYLRLKQFNTIQVSQSVITDFLDLKLTNLEVVAGMLYVPLSSGGQDFIAFLRKGQPREVHWAGKPFKQGQAVKSTLEPRKSFKIWSETVAGRCRAWTDEQLETAGVLALVYGKFIEVWRQKENALQTTKLTNLLLSNATHEVRTPLNHIINYLEMALNGPLDFETRHNLSQSHAASKSLLFTINDLLDLTRLESGNETSFNEPFDLCDAIRDAASLYQNEASRRNILFDLDVSESPKIVVGDSKKIRTVVQNLTANALKYTKQGSITVRCQPLPEEEGGLRWPGATVVVEIVVADTGCGIPPVKLESIFREFEQVESSEPKTTSEAGVGLGLAVVARIVEQLGGQLRVESKEGEGSRFSFLIPLKSSRSASNSSRSSSSLASLHRNSSHGSVRSNSDKEIDSLVEALSSNHMDGNSRSSSPRDSIDIGSRTGSFEVVDSAIPLRPIKVGEYDTNVPAIPTPKASSSLTLPPSRTRRVSPTDPELTKLRVLIVEDNDINRAMLARRLRMDGHVVVNTTNGQEGVDKVTEDRDFDCVLMDINMPILDGFGSSERIRELERKSEGATERLSYQLNGRIPIFAVSASLYEAQRNKLSNAGMDGWILKPIVFERLKVILKGVTDLSQRERDVYHPGCNWENGGWLAGVADASTATNGTSSSSSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDJ1</accession>
    <name>A0A8H5GDJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDJ1"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5362956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="498" mass="55544" checksum="FA5BF3385AE8B902" modified="2022-01-19" version="1">MTDRRAASADPNLQCAKRPHVSHPPSIRDTAYFVDDPWTPCTVQLCLNRYNTQKLPVEKIPNGLHVITQLQEFAIQKAHPKPKPATESEQGTSTPTNQPSGSNPVPETPPDNPPEPDNPTSPSSSPTIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDPFNGGRSEAKRWLALFNNYLRMNKGKYPTEESQVSLFLSFFTGEKGGDWATQRLMERDADEENENLANMPGEWRWITLKQIRDRFKKDFKALASEDVARTKIKFARMRGTDISSYNSIFDTYGEESEFGDVALLEFYQDGLPPKLREAVGRTYPKWDDFNEYKERAVELHLEWLKERERQGRWKTTSTSKSSPGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKEGACFACRQTGHMSNECPTFPKMSSQNTSRTFPPRTIRTAETASPPLVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GG79</accession>
    <name>A0A8H5GG79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GG79"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="160" mass="18297" checksum="B116759A97D4E3D3" modified="2022-01-19" version="1">MPGSRKQWCEHCREYISQRRANQHRAFLFNPYPTPSILNSSTSTPYTRHDDNLGDMSWDEPPMGEEPSSSGQGSFTGGGLRNIRDWVEDVDDEEDLMDAENWTSLELDDEDESSQGDEEEDFDWDTFIQQHRARHGNLSAEEQFGASYEQEAAGGMSMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH21</accession>
    <name>A0A8H5GH21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH21"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="83"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5364668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="536" mass="58068" checksum="5E5AF2BB21EE5E77" modified="2022-01-19" version="1">MAENSTSNSPTGTINDETVDIEKGRKETFGKGNAAAESIEEGVEPSAPGQSSPEDQEGEDVEYTKDFGIIPIPSRLQYHPNKSFHFGLVLQIVFGFASTFVVANLYYCQPILIPLSEAFNVSYSQVSIVPTLIQAGYATGLLLISPAGDLLRRRQLILLLVILSLSLSVGLAITSSFRAFEVLSFFVGAFSVTPQILLPLAADLAPPAKRASAISVVFAGLLLGVLIARVISGIIAQYSSYHVVYYFAIGVQVLVLFDIYLLVPDYPSKNRHLTYVEIMWTMAKYTVTEPVLVQACLINLASSASFSSFWVTLTFLLGGDPYNYSTVVIGLFGLVGIFGVCMGPVVGKFIDTLIPWYASLLACICLLLFQAVQVIGNGLNISAVIIATLGLDVFRQMLQTSLAAKLFSINPSARARLNAIYILSLFIGQVMGTSVGTKVFLEHGWRACAGVSLAYGGWQIFALLLRGPNCGRFTWIGWEGGWEGRIRKVDNQTQQNAKESGKRETSESSRSRDGSAVADSTEKDAEKGEDGGQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHK3</accession>
    <name>A0A8H5GHK3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHK3"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1185" mass="134201" checksum="DC307CDFD8C4D97F" modified="2022-01-19" version="1">MPKEKKLKKRKRRTLSKPKKRTPDHVKEEQYEVEIIKKARVTEKKTWEYLVSWSGYDTDEDSYVNSLLYSQLDHSLQSVISSSENLEVWLMSSPIIGRSLCHYDFWRGHKSQLSFLESELGGSPGIQRDERDPPEPGTVLTPTNEWIEEERAYFHQAYVLRLPQPHVQNNSEDDEFLPLESSEGEFSEPLREPRSQTARSTIRLHLPNRSSKRQPQSVQEDSDSEEIDEVIRPRKRKRVVPKTPEVDGAEEDEDDEDDDDDVPLTELKAFRDEKMRPSANASKSAALSQPTETYFDITSLSINDSTFASEDPSPPMKATPTPSNMPSISISPKPKPPHLFIPSSSTHRISTSTSFQAPPFRKKTDKGKEKEKPKPMTLLPTPSSATPANSGLTTKRRLAESALNLSTPKEIIAELDKKRYESFKFKKLDPAEVAMRAVETGPDEIREKAQDAGWQQSTVDEDPQMHDSSWPLEQDSWRTDIYSPDFGRSPLWPTRTPEFVPSTSLLSPPPTPVMERTMTSFNARPSPSQSPVIEPKYTAGDHPNSSRSDQQERGRVDGFDDFDSFRLDDHIDGSGLLGFKDLEPAFEDLFLDLANDVSCSALPVKPAEIDQQAEAARNPPIPVTPKSRKLEAVDKPNFFFSPRKRLPATHRPWKWSGRIRLFMEVQLSSVVDRKGRIATPSFEELCDAALVTTTPVVRDGMSFMVAMSSTKALDLKMFNVHALCSILPACKKVQQVAVLREVLDSRDDTMVNGEEDVTDGALKKLGKYMISQKMIPMVEFYLDQRPAGIIIFIPPNMRGLLEQLGIPIRSASQCSFIAALLPWSLPPIPSRGEPTKNMWENPSSSSLTRIPVASMQTEPKSSTEMGFREKLRFLRFPSCLLEVLQSGTRKPYYIFSDAHPSKEVDLECKILQSILQHPSLARQTKYITNLTEHRNSVRLVFLHAASLPDLHILPFLADLKRKKCEEGALDVGFYLFGSSSAVDRNQWRFEEVYCLGGVVTFTPLALAKNPDGLSRIFQRVSEHPLWVGYVIPSVIGLAVKLHYGALGLDVMKEFDNGTFIFNSLLSDIDNGILGLLRAPAFENRDDWVLEQADSVLRDPRDTLEYCLQDFERRYDHIPESEWIAAVELELTGDLRKMHVQPIIMDNYRRMVVLTSAGQENHNSGGLEWVNCDDFRFDDDNDDMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI90</accession>
    <name>A0A8H5GI90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI90"/>
    <dbReference type="OrthoDB" id="3157337at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="24227" checksum="9B247C745516AF79" modified="2022-01-19" version="1">MDPSPMVQDPKLFHPTGDIIIQVENVLFKVHTFLVVPRTQVLRDYLSTIENQPLESREGSSITNPLHLSGVYVEEFRAFLDVIYDLDSILTQKKRDVSYYLAVLCLSSMNLWEPGVDFAIQGINSLDPKELQPYAKIVLGVVNRQDTWVFDGVRWLFVSENPSIDQCSIDWILRDGFTLLTNTITELIHHALRFPNHDKAAWGTFNYEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK91</accession>
    <name>A0A8H5GK91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK91"/>
    <dbReference type="OrthoDB" id="2793550at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21752" checksum="A6B651571C60D8C5" modified="2022-01-19" version="1">MSSSFSSVGKKKVVAHIGIFICNLIVLALASRVNHFQEFFFVADLFPFALSIVCLVTLTIMLGLDFATANSFTGRPQFEIGLFGLLTIFWLAFNSFSTSRWGHVTMSCNAIPSGFDDVKGWCTDLNALKAFVWIEWVMFFLTTIITFRYVVTQKNRGNTHVFKMPLSRYRPREFDSFPRNSEFLQYNPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKW1</accession>
    <name>A0A8H5GKW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKW1"/>
    <dbReference type="OrthoDB" id="2917041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="186" mass="21117" checksum="4BB5D4B1A465D6ED" modified="2022-01-19" version="1">MSENGWTDQELCKEWIEKIFEPATQEKANREAHTLFMDGHSSHFTPEIIEFAMRWNISIIGYPPHCTHALQGLDVVCFAKMKHELKLEINTFKETYKRPVGKAEIMGVFGRAFIRAFTLETAKAAFRATGIHPFDQTVITPEQMKPAEATSIRSSFAMTQTSPVKAIIESFCTYRPTTFDLSPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNP7</accession>
    <name>A0A8H5GNP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hemimethylated DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNP7"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="6">
        <location>
            <begin position="803"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="942" mass="106257" checksum="86EDD9A5522F1830" modified="2022-01-19" version="1">MTASTSNAPPLGKYLASTDKKTRDKAIKNLSTFLSDSSQDAIPKPEMIKLWKGIFYCFWMSDKPLVQQALASELAEIVLTITTTTSSLGFLSGFWETIVREWNGIDRLRMDKYYMLVRRFVNASFRLLIRENWDVKIVEEYNKILCREGGPLNPADQRVPSSLPFHLSDIYLEELDKAIRTTSEDSSISPAPLKHILMPFLQLAARTNAKTTYKHLESTLLEPLLSSLSSHEDLDDEVRSRKRRRLNSGSNEEDLPYSALISNSCFDGPSSGALPAPVLKKKLLKGIFEVASEPETKDPNRRKLSTIRIRSSEVCTLTYDVESGKVSTSGPLPRLRLEMFPQLPLDILIVILEQLPASRDIEGEISAQVLGRCAQANDLFRDAAYTLGLWESHYNARYHYSDESAELQRQTQFGNNYRLRYIARRTIDRRCLDCLDKIVEERRGRYDHATTIARMCLDAWDVLDIEMRRCNRPLVFCRPDEKLDATLTREYWAGTMIKAILRTHAVRLWSNIVLQGSDTVSFVDALSAISCFVGKGPKEVYPLLDSLIKQCRDFLNERGCPTSPEDSGYSLPDICSHICEFLRSQGFGPVEAPNFHNMANLFPHSYLTTNKKTIPLSLVHVFVAIARGLGIAASPVAFPMRVIAHVSSPDPSVDDFYVDVFGSEDKAILSLRRDIPVLLARQGVLSPVDHISPCLATPMLLRTGRNILAALHTAVRVSNSMAKDAILTAFSIHLLLTRSEPLIGQMFSQVDALDVATFISEALVPGIGQSHISHHLSSACQEIMSQEVREAAVVRLRSEEETSIQHFVGLVFQHKIYSYTGCVYGWDPICLATDEWIAEMGIKNLARGKDQPFYSCFCMDGTVRYVAEDNIQPLDNCSREVFEKLKEKIDYLPRYFTGVLMNDEWAGFSRGGLLFHQKLKKLTQRMMLLGRPGWNLLLPCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRC3</accession>
    <name>A0A8H5GRC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRC3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="22164" checksum="45087CEAA80356E9" modified="2022-01-19" version="1">MGKSQSKLSPEQLADLQKNTYFDKKELQQWYKGFRKDCPSGQLDKEEFSRIYKQFFPFGDPAEFADYVFDVFDENKNGTIDFKEFICALSVTSRGRLDEKLKWAFQLYDIDKDGTITYDEMLQIVASIYKMTGEMVKLPADEDTPEKRVDKIFRNMDRDKDAKLTFEEFVEGSKQDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSA3</accession>
    <name>A0A8H5GSA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="502"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="725"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2144"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2145"/>
            <end position="2168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5370279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2168" mass="245102" checksum="B4122A7A795B0F65" modified="2022-01-19" version="1">MSGKKQDLSQYNYSAISSLVLSADRTALPRRDKEPDGAPTSLVGRIDPREMGSRVQRQAPKDMDKKKKKAADRQEPSEKQPKRKADAGTFGYADIIEATQDVEGLTYRPRTAETREVYEMILSSVHTALGDQAQDIVRSAADTVLETLKNEGMKDFDKKKELEEVIGPITSESFAQLVNLSKKITDYGDQDEAMVDPDMEKKEAEIDEEVGVAVVFDEEEEEDEDEEGFEVKEDTDEEDEEEGEKEGTPAAEGDVGEEELVIGGESSRTKKAQADKDIVSPHAIDGFWVQRQITEVYPDPVTAADKAASVLSVLGSESSLRDCENQLMELFEYQSFHIITKFLKNRDVIVWCTKLMRSDADERVNVEVAMREKGVGWILRELSGDRQAKTRPTDSMDVDEPVKQVPKTATLAPGSTTQPKGTVDLESMAFSQGGHLMSNKKCKLPDGSFKRSKKGYEEIHVPAPKSKPEGNNERVPVSDLPAWARDAFTVPNLNRVQSKLYPIAFGTDEPLLLCAPTGAGKTNVAMLTILNELAKYRDEETGSFDLDAFKIVYIAPMKALVQEMVGNFTARLKVFGIKVGELTGDSQMTKQQISETQIIVTTPEKWDVITRKSTDTSYTNLVRLIIIDEIHLLHDERGPVLESVISRTIRRMEQTNEYVRLVGLSATLPNYKDVATFLRVDESKGLFYFDATYRPCGLQQQFIGITEKKAIKRYQVMNEVCYEKVLDQAAGKNQTLVFVHSRKETAKTAKFLRDMAMEKETITQFVRADGATREILQEEAGNVKDPNLKDLLPFGFGIHHAGMSREDRGLVEELFADGAIQVLVCTATLAWGVNLPAHTVIIKGTQIYNPEKGRWVELSSQDVLQMLGRAGRPQYDTYGEGIIITNHSELQYYLSLLNQQLPIESQFVSKLADNLNAEIVLGTIRNRDEAVQWLGYTYLYVRMLKDPVLYSVGVDYLEDDPSLIQKRADIVHSAAVLLEKCQLVKYERSTGKFQSTELGRIASHYYVTYNSMMVYNQHLRPSMSTLELFRVFALSNEFKLIPVRQEEKLELAKLLERVPIPVKESVEEPAAKINVLLQAYISQLKLDGFVLVADMVFVQQSAGRILRAMFEICLKRGWAVPAKACLDLCKMVEKRMWGSMTPLRQFKGVPAEVVRKAEGKQFPWYRYFDLSPPEIGELIGIQNAGRLVHRLVHSFPKLQLQAQVQPITRSLIKIDLSIIPDFRWDEKIHGGAETFIILVEDVDGEIILFHDNFLLLQRYAEDEHSVTLTVPMFEPVPPNYYISVISNRWLHAETRLPISFKHLILPEKFPPPTPLLDLQPLPLSALHNKEFEALYSSTIDTFNKIQTQVFQALYTSDENIFIGAPTGSGKTICAEFALLRLWSKREQPRAVCIEPFQEMVDLRVKEWQDKFSNLQGGKEIVSLTGETSADLRLLEKGDVIVCTPSQWDVISRRWRQRKNVQNIGLLIADEVQQVGGEIGPTYEVIISRTRYVSAQTEIKTRIVACGVSLANARDLGEWIGAPSHAIFNFSPSARPLDMDIHLQSFSIPHFPSLMIAMSKPAYLAISEYASAKPTIIFVPSRKQCRLTVDDLLTHCAADEQPDRFLNVDLSDLQVHLDHLSDEGLKETLKHGVGYYHEALDKQDKRIVQRLFESGAVQVLVASKDTAWSLPVASYMVIIMGVQYYEGKEHRYVDYPVMDVLQMMGRACRPREDERSRCVLMCQQTKKDFFKKFLAEGLPIESHMPVMLHDYFLAEIAVKTIENKQDAMDILTWTYFYRRMTQNPNYYNLYNVSHQHLSDHLSEMVENTLSDLVNSKCIAIEDEMDVSALNLGMIAAYYNISYVTVEIYTLSLKERTKLRGLLEVVSSSAEFEIIPIRRHEDVLLRRLYDRLPVKLEASSAEFESPHFKTFLLLQAHFSRIALPPDLVADQKAVLEKVLNLLSACVDVMSSNAWLNALGAMDLAQMCVQAVWERDSPLKQVPHFESDVIKRCNDAGVESVYDVMEMEDDKRNELLQMTPAQMQDVAMFVNSYPTLDVSHELAKGEYTAGSPIYLSVVLAKDDEDEGSESDQTVIAPFFPVKKLANWWVVVGEPKTKQLLVIKKVTVSKTMKVKLEFTLPKGRHEVKLYVICDSYVGADHDITIGELDVAEGEESSDEDDSDEDEDDKMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSN4</accession>
    <name>A0A8H5GSN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSN4"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="395" mass="45055" checksum="F0E689D86299BF36" modified="2022-01-19" version="1">MDSWCIDLEPQQIQAPPSPPPPTQSSQSRLLLPAHVSVFGSVPVEILPPDVEQDYIEYLDYGGRDELPTTRYFERPEEPKQPTVLVCKHCGAKGDHVAKDCPVVICLTCGVRNEHSTLSCPISKVCFNCGMKGHINSTCPNRGRLANAYDDCDRCGSTIHTAHECPTLWRLYAYMTESERDSTLNFRRGKRMLDLGNGGEGYIAQDIWCYNCGQSGHWGDASDCDIVQHRHDIPKEYSAFSEHNTTTGPFADVTMHADQRAKQDWEQDDPMFQSWGTRVPTNVGKRGKAKEMMQLRAQQEDDDDSENFFAARMKRQDSNAKRPPSGPRRTSNAPTQPKKMSISFKSDSSTPSLLNRISDGPSSSYRDRDRDRYRDRERDKDRRRDRERDRDRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUH2</accession>
    <name>A0A8H5GUH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUH2"/>
    <dbReference type="OrthoDB" id="2961601at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="73662" checksum="F1AF2A72C4E6712D" modified="2022-01-19" version="1">MLSQQDMTETYAYHVSSTFQRKLHVATCTSHTIPEEHQPFFPAVLKLPVELITEIFMLFFWDIKQEEEVDESWSGSFGRVNALVITESEIWAPSLVLSQICSRWRAVAFSVPILWSQISVNLSNNIPGVGYLTLLYLHNSAPKKLILDVTCSNFDENGDRVTTLGQEGWTILHGIFTGFTSSRWQHVRLDLNHAVLEQFTERLLHARIRSPLFDFLPTDSLESLVLQWDTFYGPISDRAAQAFSKFFTASPTLRTLTLDLFDHSLNGFPYHQLTDLTVNEDSNSDILQLLAQCPNLQSLSIPCQSIQTMVKPKLTSHYNPGHSNILTFPHLEALTIKPLVCYPKASWIISNLSLPNLHFLDLQTDVTLSETHRTYVGMRPSEFWVQTVRALLWRSSLCHGGKGLRHLRLTGFHFNDWDLLQILAYTPNLRQLEIDAMWFYEKIFTRLFFEVLTVPWSQPFRLELPFTMRLAAGPDSKTSELQGNEEWGKVFLHRLTALSLRFSESNMAKDDFTLLIDRYHDTRTHDRTGNLPHPDWVLSMLESRTRARTSVADQGTGVTAQAEQDRSAGTDTNSSERDDKSSGWTRLQRFELWAEVPIGELRDFKNARDWKDQFRAENSATMTRMRDLQDRLDLRVTIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVE6</accession>
    <name>A0A8H5GVE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVE6"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="772" mass="83205" checksum="7F4F77B4E7621E10" modified="2022-01-19" version="1">MDVPPPALALSDILHTMSPSPAPLAHDVPFHNSGVAFTSNADTDSPEPIADEEVSRFRNRLDELGFLNEGNSSSLNPKERELADMVIRLTEPSRPSTSQIVEQATVISELTTQRDFLKQSADEERARWLSEKEGWERSAEALVSQRHRRGHYGTKNEDLERVIAMLQSENAGLRQREYETASRLVALENEMSKLKPLLLLQPFPAGSTPISLAYPSTYLASLPYPASSGAAAFATQRHRLSRKRKREKDKEPEEPEKDDAPPPVPVSINGKAIGENGASTSTLVLAPAPNIHTGPSKPRTSPSPSTSTHPIDTTPPNKPTTPAIYQHLLRFAPTQPQHSTSQPQPFDSPGKTIRNPNPRSDKPDKIKSVRTSSLTSDARTEHLLLAARKIGRERSSVVAGIIEAEQEKAKRKEQQDRETMETGKSATTKYYRNKNDGWHRSESADGLTIVNVSPGTINGTSKHQKKSAAPKPFLYAGNPSAPGVNAQQPAPTLPHAHAAPRKEIAGTASASVAPAAVQRHNPPTPMDSLLDAARSMMGNGEGAVASSSQIMDHARGEEKKRQAAFNDPGVDLPPKKRKISSSSKSLAVAAESAPRDVGRVPSALDVLADQADQVAKGKGKETMREQSVDTTSSTTTKLVKKPRVKSTSTKRRNEDGRQAGSTEPGEEPSMSRGSIPRMIASPGSFSRRGSASRSEAERDPGAMELANAYNVSASHEGFELIADPRSTGTQPNVSRSVGGNLPSLSRRGPNGHQDADAEGETDVEMDVTNSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVH3</accession>
    <name>A0A8H5GVH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVH3"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39438" checksum="0F337BB74AE6AEFE" modified="2022-01-19" version="1">MTDWSSPAELQKDSDIFIKLMHVLTGLYIWEFILSLHFDWDFLTRRKPFRWPMIFYFLDRYLLLFALIGILISLDSTVRLNCQALYIFNQLAGNAAVGLASINLSLRTIAVYGNSKPLVILLVLVILGHWSLILQGVNLTAEWSDATNSCVITKTNNTVLAATFIYSMCFDLFVFLLNLHKLYFRRESPQGSMGTSRLGRLIFGDGLIYFFIAFLANVIATVFMLLNLNAIMSIIFNVPAAIASTVVACKAVRRLSTFKNQGAEVYMSGTSAHSLQYRGPGVAPNSRPAINPHSPGLSNGVHVQMETFTREEDISPTSPSPYHVHYDDDDHKRTRTMSGGQDYDIESKATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVI2</accession>
    <name>A0A8H5GVI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVI2"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5371580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="272" mass="31524" checksum="49A21E6D4EC6C90C" modified="2022-01-19" version="1">MRGNVSVGFGCHGRRKTCLDNKQKCFSFTAMERVQFEQEQMLDELKDLVEKKLFTVKETKQILKQRTQYEAALVRRVAKKADFLRYAQYEMGLEQLRRKRAERLKIPSTPKTISDYALVRRQFNIFERVLKRFKSDVGLWIEYIQLAKKEGARSLVGRITARALQLHPNVPALYILAASHELEHLSPTSARSLLQRGIRMNGESVEMWTEYIKMELGFMESLRRRWQTLGVEENEIVKGSIVKAVVTEAAQALPDMAPIDQVVEEYAMDEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWW6</accession>
    <name>A0A8H5GWW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWW6"/>
    <dbReference type="OrthoDB" id="3111084at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034619697" evidence="2">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="192" mass="18883" checksum="BAD64E2C02DB9699" modified="2022-01-19" version="1">MMKHTLFASSLVVFTNILGSVVADELTLYEVFDSSAPVPVPVDAAPTATLAAIPIGVADGATTYLIEAIATDSVIDTVITNTGTIVASAAGWKVTEPVEDGVGGGEIGCSTPDAQGNGECIERENLNGTTFAFTQTGSMFSFVLSVSPTGAADTGGSSGSSGSGSGNNNNTAGNGGSSGSGSGSGYRKSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXE2</accession>
    <name>A0A8H5GXE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_001449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXE2"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034209702" description="Cerato-platanin" evidence="4">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5372979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15718" checksum="244D6B2091FC0075" modified="2022-01-19" version="1">MKFTSAAVSALTLALALLPSLTSAVTLQYDNNYDDKSFSLSNVACSDGPDGLMTRFGWQTIGDIPAYPNIGAVDAIAGWGSSACGSCWQLTYVDENGISHTENILGIDHAGSGFMNVAQQTMDELTDGNAVFFGHVDVQITQVDASACGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXM7</accession>
    <name>A0A8H5GXM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXM7"/>
    <dbReference type="OrthoDB" id="3251271at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="251" mass="27130" checksum="6853AA79A611A9E2" modified="2022-01-19" version="1">MSSKTLSTGTLSLRFMQNAQRAKQQKEVELEKAHVEDDGQWEIAKEVRDSWGPASQTDNAVSYETSYLPFLFPSLSGPDTTSSTRPKGRRTFKKGKEVISQEVISQAEPESEPAASTSQSPSHPEATQTTKKGKKAAKSSLLSSDSNDRITKNIKSERPISKSNKIAKLAIFDTSGVGTDLRAAGATSVASTTTTATSTFMKPAGVDDPKSSSDQQIISSAREVKTKRVRRKSAAGTTEEVKTKKRKTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZI3</accession>
    <name>A0A8H5GZI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZI3"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034889925" description="Serine carboxypeptidase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59648" checksum="D6D8C64BB02A2571" modified="2022-01-19" version="1">MLGSRLHLALVGVALVFLILVDSSQGFKMNKKELQVHQTEAVKKFKERGVNSRAAGAAEGSEKAAPVKNITFSNPKASEFFVDGSSIPLVDFDVGPSWSGLLPISADPNETRKLFFWFFPPGPEGSLDDIIFWTNGGPGCSSLEGLLQENGPFSWSWGTAKPIVNDHSWTNLSSILFVEQPVGTGFSQGTPDAQDENDVAEQVVGFMEQFLEVFSELKGKNLYITGESVRILFCLRIPSFTDHLYESMREYIANFIYENPGQLDLNLQGIWVSDPVLGWDVVQTQIPAANFVHKYENVFALDADTMADIDATAARCNYTGYMEKFVSYPPEGLLPLPGKSTEADRGCDIWDQIFDAALAVNPAFNIYRIFDTFPILWDVLGFPGSFPNEQTTPLYFDREDVKKAIHAPVNVTWEECSDINVFPNGDNSLPPAFTVLPNVIEKSNRSVIVHGLADYILIAEGTRIVIQNMTWNGLQGFQTPIKNDSFVVDEMGVPLGTAHTERGLTYYEVSLSGHMIPQFSPPAAFQIMQYLMGFRDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZK0</accession>
    <name>A0A8H5GZK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZK0"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="161" mass="18381" checksum="63FF9FF293C6FC00" modified="2022-01-19" version="1">MVVLVTSDNEQFTADKEVVERSVLIKNMLEDVGESDQPIPLPNVSSSVLKKVLEYCEHHRGEPLPAPDADSSQDDTRKRTTDISEWDQKFITVDQEMLFEIILAANYLDIKSLLDVGCKTVANMIKGKTPEEIRKLFNIVNDFTPEEEAQIKKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZS8</accession>
    <name>A0A8H5GZS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZS8"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034905819" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="14676" checksum="4F662570BB7FF1D5" modified="2022-01-19" version="1">MHPTSLTSFLLAAVALTLPSVQAAPAPASAPGFLSGTQTGQATYYSTGLGACGITNTDADHIAAVSHLLFDQYPGYNGGNPNSNPVCGKKIKATYKGKSTTVTVTDRCEACAMTDLDFSPAAFKDLADPSLGRLSGMTWVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H070</accession>
    <name>A0A8H5H070_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H070"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034981038" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="46" mass="4927" checksum="D898AB07DD6FB474" modified="2022-01-19" version="1">MWRFPTLTVSAMLLLILQSTVVVVNAAPAPAQAPEFAGELDTTAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0H5</accession>
    <name>A0A8H5H0H5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0H5"/>
    <dbReference type="OrthoDB" id="3174721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="271" mass="31015" checksum="8943C1AAA750228B" modified="2022-01-19" version="1">MSERSYVTLPDPETSQPLTQHAMDPIPEVVDRTLETTASVDPQGLLRWAWHPPSPSTAAEEQPLGNDDHHVPFGAPPGYTRAERPEKNVTYSLSAGAPNTCLLVPSADSPNTRPRFHVTVAVRQGGTENGRFVAEFEIGHDQLKSKMADWITYGDLQRQPLLYVLHEQYYTTKDTRIKYSSGEFYWWFFKRPPETVQWRCYATAEETVKKQEEAKLYATYTPLKQVRHGIRVETLVLRQLEVTPEAHDFLDQILISLLILERRRLAPKFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H198</accession>
    <name>A0A8H5H198_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H198"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="91" mass="10098" checksum="8723611162313E9C" modified="2022-01-19" version="1">MFAREDVEGTREPESCWGISQEREGIAIGKEGSDFIMEVRERDTGSVKGYCQLELSKNDGAGVFDFSVIAIFGRLRVKDDQETLTVLGHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LG85</accession>
    <name>A0A8H5LG85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LG85"/>
    <dbReference type="OrthoDB" id="3197907at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="21514" checksum="C99CBCD77A2E2CEE" modified="2022-01-19" version="1">MVGQPKLQNQWDQEASTAKLGKMTKAVANWKEEQKKEKSRSLRAFAQDYDVDPMTLKRQSEGGRSIHEFNATKQKLTPAEEKTIADYIVHKCEQALPPTPSQIRSYAEWIRKTNHPDKPPIGETWVNEFFKRHPEVSTGWSNALDTQRAQALNPTVVKKWFDLLEQEVEEKGISACCKWGMDETNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJ37</accession>
    <name>A0A8H5LJ37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJ37"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="31379" checksum="D77C352DCD9C88CC" modified="2022-01-19" version="1">MLQELEPLDPAYVKDVLSNPPFVTLPGVINVRDLGGYPSVDFPDKHTIPNRFLRSAELSSITDEGKELLKNLGIRKVFDLRSDTEIEKYVAPLPTIEGVEVIRCPVFQKQDYSPEMMAKRYQLYASGKTEAFMELYSQILDHGGGAFGTILRHIGDNPDEGCIFHCTAGKDRTGIVAAILLKLAGVADDKIAEDYALTRVGREPARDLIMQRLSKEPLFASNNEAALNMFTCRPETMTAFLELLRDRYGGVEEYVKKYCSLTDEDIVTIRANLLTSQGSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPI4</accession>
    <name>A0A8H5LPI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPI4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="15899" checksum="84145AF8A797E19B" modified="2022-01-19" version="1">MIFVQTDANWLELPLFYTGFLNTRTWLADVREHADPHLTCILVGNKVDLCDDNSSKRQVSVEEAEIFAKEEGLLFVESSAKSGQNVEKAFEDAVRDILEKIHRGVFDDDRSPGVKQLSKPSNNSNANNVSLTPGASLSKPACCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPZ1</accession>
    <name>A0A8H5LPZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPZ1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="28" mass="3103" checksum="66D695D8D419A3AB" modified="2022-01-19" version="1">MSVAITGGNPEAYRDTFKLDIIYVNVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ17</accession>
    <name>A0A8H5LQ17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ17"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034034070" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="221" mass="22066" checksum="6CD0471346027BF8" modified="2022-01-19" version="1">MFSKAAIISLLATGALANVFITSPTESIGMTGGQTATISWIDQNGGPSLADFGDAKVGIFTGNANQQTLLQLVVDNVNVATTASIQFTPDASIGPNGNDYFIRVESINLKDSASPQFPALAFSSRFTMSGMSGTFNATVQAQIDGQSTAPIGGTAAPSTATSASHSASTTGSGSPSGTKANAAASPSSTAKDNNGAMSMATTTASRLVGVLAGVVVVSYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRL2</accession>
    <name>A0A8H5LRL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">D9758_003657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRL2"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="234" mass="25632" checksum="942CC9C329619085" modified="2022-01-19" version="1">MAFQPSKLGTKEHWDKVYEEELANFKEIGDEGEIWFGEESVDKMVEWTEENLPPSDDLSILEIGSGNGTLLFALAEAGYSQKVLSGIDYSPDAVNLSQAIAATREMNTIQFNVCNFLAEDTPTLPKMAGSTLEAWDLLLDKGTYDAIGLGVKDDEGKSPAAKYPARAARLMKPGGFFLITSCNFTEDELKTAFSACDTGLQYHSRIQHPTFSYGGKSGSIVSTVAFQKKSQIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRY5</accession>
    <name>A0A8H5LRY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRY5"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034252187" description="RTA1-domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38882" checksum="449D7E76A6B55787" modified="2022-01-19" version="1">MSSTTRQSFQFFLVSFLALVGSSFIEGVEAQTSDDDSSTQNGHVDSQGRRIIAGFIPKNWASIIALVAYGVSGAIHWIHYFRIGKRHMLTLTIAMTCMAIGFIARIVYSGSPDSLGLYIFTTLFVLLSPCAFLAVDYILLERLAENLGHEVAKQCLFLSSSLIVKIFVWADVLTFLLQSSGGGLQTSDNESSRHLGSTIVIVGLVFQVVSFGLFTCLLLVFGFRVRTSYPQLWHVKTSQTIGSTIGLFKVSDVHDWRILFAMLCASCVGIIVRLIFRIFEYAQGFDGFLSTHEGYFYLLDALPLWLAMTQYCFFWPTRFNPRRASDKQGQPGQPGQPQEWVGLQSRGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS45</accession>
    <name>A0A8H5LS45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS45"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034981093" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="424"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="520" mass="56237" checksum="BE6E59DCC7E97462" modified="2022-01-19" version="1">MLSKSAVFRLLFLDAFAALSSAALTSLTLPGPATLPADASPPLHPSLASFSIETAFFIDYTGNISSPNILTKNLLENLKNRTGVPAEIRIGGITADSTYWDASLDTPIFNFIDDTGALQNTTIGPQFWDVVRELLPEGTKITVNLNLQDLNFTGALEVARSAVEGLPAGQLVALEIGNEPDHYLSFTPQNYTGIWRPWSVNVSDALNLPKPFFQLGATAEDPLFPFNTPTANRQLDCVSALAAGANDDGTVKYCSEHTYQYSVCDPARAAVATLRNLVNHTRVAQYLDLWQPRVKSVREQLGPDSFVIDTTFYAASNNVSRLYIHQGGPLALQSSTQLNHGGLSLYDLWWPVDNQNGPTQVFPHYSAYLFVTETLGTSKSLRIANIFPGRQENGSSITTALGDESQGQLVVYGFWDESLPSGRHTPSKLALLNLEAYNSTEGERPLVSFNIGNYLPSSDAVVTVRRLQAPGIEVKTANLTTWAGQTFESGVASGELKEEKISGGVIEVEASGAVLVSIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSR6</accession>
    <name>A0A8H5LSR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSR6"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="538" mass="59967" checksum="74E8838B2C34B5EC" modified="2022-01-19" version="1">MASLIPPSNCTIAIAAHTDIDGIGTRIATYCQLLFAILTLAIAPRHGIGSWWAVIITSLGLQITAIVEHEALSLYHALIVTWLTFPVFMMTFYYGLLAWGRSGFVTEVVIGMVLHGSIFIGFCFWVWGTAPSFGDDVACNSEVKFALFSLFNPTGGVRTFALFVITLFALFMLCIFLFLGCYSAQYAFTLISPFMNRWQKGPTPSYAAPIISRRLINMLNHVPPLHTTVAVLTTINLCSLILSICQIESMIAANAWLITPGSEEWTFGQILSIILLTNPLLNFFKVVKIEYEQKESLEHRPAASLCVQVHKKWKSARDSGFSLKGSYLRGKARDDDISPGETKTLPGLPSYNVTSSPYLFENAGCRQDEKAEHDGEEQSQSYLPRVDDYAVLSSCDDTQYARSRLSDLENADHSSAPSYHTLVQEVKDDTSRARVTSSTLEEHQHQPLPSLVSSALSLSSPMPSSPSGSHSGGRTSEHSPRRTNPSLHVPRSSRTNSIPPERYNTLRSFWDRRRDDHDYVTTDSRRSRGERERDMFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LST2</accession>
    <name>A0A8H5LST2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000016">
        <property type="protein sequence ID" value="KAF5368168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LST2"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="258" mass="28033" checksum="5D27F9ACAA541D8E" modified="2022-01-19" version="1">MIRQPSSSIVSSQQMLLQRHIPERYSYSQAASISLAVTCGIFGLLAPKPIGIALNPTFDPTVKFTGQPALCIGGSTSVGQYVIQLLREFQFSPIIAYASAKHGPYLKELGATHIIDRQSVSFANLPSTVSNILSETTSSPLKLVFDAFSGYDAQKAGYTCLADGGDIVTTYMIELKPEELVDSKNLLQVIGTVHWPHTREFGKQMWRALGRWVEDGVIVPNKVEDLPNGLYGIADGLERLKNGAVSCVKLIAHPQDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUC4</accession>
    <name>A0A8H5LUC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUC4"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="62"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5369892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="491" mass="53017" checksum="9C6F0472C48050F5" modified="2022-01-19" version="1">MASRRVISRLIAATQQSACPCHGCAAGGHPHHQAHAINQLRSFATPVDTVQKEYAFEVAASNLRFGDGVTAEVGMDLKNMKARKVGVFTDPIVAGLAPMKTALASLQSQSDLPFEVYDQVLAEPTEDSWRKAIAWAREHDFSHFLAVGGGSVIDTAKAANLFTVYKDADLMDYINAPIGKGTAVDRTLRPLIAVPTTAGTGSETTGAAIVDITSRSFKTGIASRALKPVLGIVDTQNTESCPTEVHISAGLDVLFHSMESYTAIPYTERIPRPANPILRPAYQGSNPVADIFSMWALQTTVKYLPRVAKNRDDYEARRQMLLAASFAGIGFGNAGVHLCHGMSYPISGLNKKGPKYKHPGYMVDHPIVPHGVSVALTGPAVFQFTSPSSPDRHRQALAIFTNTTITDSSITRIPDREVGAYLYEAIARFLDGLGVPRGLKAIGYKKDDIGMLVEGTLPQRRVLDLAPGIGDFAGEDGREHLTKILENSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUP4</accession>
    <name>A0A8H5LUP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUP4"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="394"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="927" mass="100918" checksum="687DF4BF9AD889AC" modified="2022-01-19" version="1">MDKLTGQPRPSLLGVSSALFLLLFFTNILPYSPFTRPTVDASLLSRCKSLKTPAGPPANFHSRVQSDRFVPGTRPTLIKNAKIWTGQDNGMDVIQGDILLDKGIIMEVGRVAHNGREGSNVLDAHGSWVTPGIVDLHSHLGVYSAPSLEGSEDGNSIKGTIMAWVRAVDGLNSHDDSYNYSLAGGVTTSLILPGSANAIGGQAYPIKLRRTHERTPSSMLLEPPYQINSSLPPNPSHIPWRHMKHACGENPSSVYSDTRMDTLWAFRDAYNKASQLKKKQDEFCAQVEAGQAKGDFPDDLQWESLVDVLRGRVKAIDLDALVRLSNEFKFPIAAFHHASETYLVPDTLKRVYGRSHLKYSIQASNAFVGHPPAVALFATNARYKREAYRSSEFAPKILSENGLTVIMKSDHSVLNSRFLLYEAQQAHYYGLPSNLALAAVTSNAAETMGMGHRIGYVKKGWDADLVLWDSHPLALGATPQQVFIDGIPQIEKPHIHKKSAAFQHVPKVPDFTKEAQDAITYDGLPPLTSSSTTPNTVVFTNVKSVYTRSAGAVEASFFVQDESAYGVVVVRNGKIICTGTESACLTNSVLDDPEVIYVDLKGGSLSPSLVTFDSPLGLSNIDQEDSTNDGMVLDPLLQNLPKVLGDDALVRAVDGLEFQTRDALLAYRSGVTLAVTAPSHRSFYSGLATSFSTGSSHKLEPGAVVQEVTGLHVSVRHFGTPSVSTQIAALRRLLLDPKGKWFEVLEGRIPLVVEAHSADIIATLVLLKREVERETGNRIRLTITGASEAHILTKELGEENVGVILNPARPFPFFWEDRRILPGPPLTEHSAVTKLMEHNVTVGIGIQEIWDARNLRFDVAWASLEADGKISKEQAIAIGSINLENLLGLDVQTEGSDIVATMGGDLLEMSAKVVGIVSPSRRLVDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV52</accession>
    <name>A0A8H5LV52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV52"/>
    <dbReference type="OrthoDB" id="2337158at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="468" mass="52252" checksum="DDB76E78D6DE741E" modified="2022-01-19" version="1">MVTTGLIEGEMNLHQSGLADAAFEEGLYSTGIATLGRLRSPKNAPSPYHIDQLLYIALYPPSLGKENNVPETPASPSKDKRLKELFAFSSEDVVAAQNLLFSFAITNTPEKILRALPSYSTETRKPLRDVDDLDSLFAKEAHQTFTTRCKNCWSILGEGFVPRVMQRAQQRGKDEILYQRDTDELDVELSPLSYNALPIFDWLLTLFERDEMQTEEQQLPRHSPLFLSSIPPSPNGKGVRWESDGPVGVLFHTLQFDERGKALGARLLSLLINLASTTHTDFASFVTTIFTRLSTDTVEVFMDMLSRMPPSLPVLRVRISILQKLLGSKSSQAPTSARPKPQARARPRPVRRVATNAEEPKQNEESAAQIAPTATSIASNPLLPSFTEISRAMEASSHCFPDANLSPSQLQSELLLGYGQYQQQIPLESRDKDWLAFLGDGIWAPFLDSLLDYREVLNGFLTIWKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYZ6</accession>
    <name>A0A8H5LYZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYZ6"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5374737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="140" mass="15703" checksum="C4C8B59A2445AF54" modified="2022-01-19" version="1">MASTFFTWLRSPKAREYFFSTHFWGPVANWGLPLAALSDLSKDEEVISGTMTTALTGYSMVFMRFAWRVQPRNYLLFACHATNATAQSVQLTRFVNYWYNGGREEKLGLTGAVQDATNEVKDSVTEAVKTAQDKAKSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZ07</accession>
    <name>A0A8H5BZ07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000317">
        <property type="protein sequence ID" value="KAF5331794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZ07"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5331794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="89" mass="9256" checksum="08202DC202B39039" modified="2022-01-19" version="1">MFDAVPRLTALDSDLPGCLSLLSGVAPAYPGHIPLTRFENAFLAVGSGLMSLADPYRGDMISALGETTAGPACPDYGTLCYTARRDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0R5</accession>
    <name>A0A8H5C0R5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000294">
        <property type="protein sequence ID" value="KAF5332985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0R5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="21285" checksum="0925F888E65DBEEC" modified="2022-01-19" version="1">MPSPSAQDNDFIVVAQSQQSDAPAEHDDADQDQGTYTRQQIQQISTYAKIPSFILLKNDLIKGNLSSFHFQPSEHEHDDPPRSLCVRVFLRPNAECIVKLEEYLAVLDNTEWGRADWLVFEEVLGISDSDEGQRRFKYRGYYSVNKEYVPTTRGARGLQEQEQMSVSVSFIVEKAADSLPLAASNLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C393</accession>
    <name>A0A8H5C393_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000266">
        <property type="protein sequence ID" value="KAF5334173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C393"/>
    <dbReference type="OrthoDB" id="3363891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="899" mass="98181" checksum="65B723B7864C4E0A" modified="2022-01-19" version="1">MALTQSARIPGPGPSWDEEVVPVLRQRLENESRTLARRISAVSASSNDDLASDTPYNPNGYSNHSSRTRPAASTRTSSERSVNSARVNGASSQRPPSSRSRTYSQPYQVDSQSSKGKQVNGVNYSRPGSATRSPDNLSSSQNSIRPISPRPSVTDTPKPTRIPQPTRSRATSIAGHSHSSSQNTNTVDGLLHGSSHQDPSRSADLWIVHEAPPTIASSAASSLTSAQRHAPDLLQEPAPFKPGSTSSSYENLDTNLSKPRPSNDSEERPFEHWYRGEVSRNGGVGELRVAKRQEMLEIANFGHDLEKKQSGPRNAITDAIEERRRRRKRADSLGEIGERASFYMDEEKAREIARVLDENPLTDVEDGDPMDIDYDEDGDEDGESEYYDPPEQTRSHSSFDHYNHSATTAAAAASSSSSSRYYDPRSTTPTPATVGGPGARSNPRTTTPTMQRGRSEPPPLPERESGPGQQQSRTKSPGTPSSSITGTPQRGKRGASPGTSPGTPGSANKKSRMTASKATQAKLAAKKKEELEKSRKSVAYYPDPGENEDMAHAIPTWTQPVPKQGNWDDVVLPVVARKKGLDGHFQQADGSPRPKESSDMVAPAPGTFGYDHSKYRPPREDIPMDEFGRPMRPIQGGRQGDDDLDLDDDYTTPTQPNPNHTSNPNPYDEVPLPTSSRSRQNGYGDQQPPHSPAPFSDYGPHARREMRMGPMGGMNGTEVDLERLAQEGQGQGQKEQGQGQGQGQDEEEVSGGCCNSYLLRYLMSFHLRTLPTSTPRTLELSPFSLSPSVCSSLRSSLPLHVHGSLPFVLSVVAHYQSPFVVSSSLLVSSLCSGFVRLLYLLWLPPVMSWARCGGNAFVIPPLYRLHYPAPTPTLRPIPITHPYRYHPQVSVCICLVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4E5</accession>
    <name>A0A8H5C4E5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000279">
        <property type="protein sequence ID" value="KAF5333923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4E5"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="749"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="782"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="815"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5333923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="953" mass="104999" checksum="FD1E395A6B5AD24E" modified="2022-01-19" version="1">MKIQAQLIKRTVKVPNATSTDEVALTPAESINQAMHPEGVRMNAGGNTYNWNNVQGNQTQNINNDNRHIINSNNNVFVRNVNESSKIQEWIDAPNPSINFNAAYNKMTKGTGVWLLEDSRFNEWKDEGGLLWLQGKAGSGKTFLCTKAILSISTEHQVVYFYFDTLDQTKSKGTYQGMLSSLMLDVGLQSDWEHIKDLYKQNNEGRIKMPADVMKATLLKLLVQKPSTTCIFIDAMDECQASDQHLVSRLILDLVELGSKIHIHTASTVGISSATYEISLNEQVVESDIQRHIEQVLQDRPLSVDVHKEVTEALAHGAHGQIRWVDCQIQQLQELGTRTAILTALKNLPDDLEETYCQALVRVNKHHQKDVEAILKWLLFGYKELKLELLPEILRVNIKQQTLEDTQTIPKSGLSKIISSTLVIVQEGQTWRARREYVLQLAHPSVKEYILSEKILQSSAQLFHVNDQMAHKFIAQLCMIYLVVCGKDGSIDQEKFPLAEYAAHQWTEHVRNLHLLENPVKSLSVHLLTNTNKPCLASIQQRYYLRSFGSALPLYYASMAKLPNVILILVEEGANINAQGGQYGNALQAASYEGSEEIVKLLVEKGADINAQGGPYGNALQAASYLGREEIVKLLVEKGADINAQGGEYGNALQAASYGGSEEIVKLLVEKGADINAQGGQYSNALQAAAASYEGREEIVKLLVEKGADINAQGGQYGNALQAVSYWGREEIVKLLVEKGADINAQGGEYGNALQAASYGGSEEIVKLLVEKGADINAQGGEYGNALQAASYEGREEIVKLLVEKGADINAQGGYHGNALQAASYGGETDIVKFLVEKGANVNIEGGKYGTALQAACVAKEKDHCDHGFYLKQVEILLNNGADINSRGGRYGSPIQAAAFQGNQEIFDLLMQRGAAAIDPIFTVFQEDPKIPFPLMDNEPADHHIYCPVFWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4P0</accession>
    <name>A0A8H5C4P0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000279">
        <property type="protein sequence ID" value="KAF5333922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4P0"/>
    <dbReference type="OrthoDB" id="3112770at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="442" mass="50291" checksum="DCD65F62A797D5D5" modified="2022-01-19" version="1">MVFLVFHDWVVRPVSARVKRDAWVYVLSFRNGKACKIGCTRRTPRRRLQEWRCKDKSKGFKLVYSVQVSKERMFGIEHEAHQQVLKYTHKSNGACPNCSSKHREEFIFKAAFGLRDACDAVDMAKELSVTNQFTTVMAVVSNYSLALDIKPKITWTENQEKSLTRDYPFVLDHNEDPQQHYSISLSLLRDTVDFQASWIRYATKKKQKSWELKRNSVHFSSRKSPNLPFSDEEKEAAKDDASADIDTRHHKRARTSVSVAKISIKRDSSKLSKHLTVSLSSSSTRHPSPALSATSSTSHTRERHPSRPLEHSRSRSLSVTLAEEEHQKAVEAKERQHQHADSVGIGGVKKRILSQEVSMTRVFKPKARSQTTMVTVEKTVKPVVKTEPKDLVVTLVEATLEKPRIVPGRTLNLSRLQLQQAVPPLPLLLPHSSSSLQVCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5F7</accession>
    <name>A0A8H5C5F7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000243">
        <property type="protein sequence ID" value="KAF5335421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5F7"/>
    <dbReference type="OrthoDB" id="3226582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5335421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="332" mass="37480" checksum="CD6E42A5F49B126A" modified="2022-01-19" version="1">MSGLAVDLLRLDLKLYFIQSTLESLVYGCYIVTFGMSMYTLSQRRKMNKSGLRWDVCALVLLFLITTVVTITDLIANASILYNTFGLGGLRAGLSKAQIHRFDISMQMVAEMGFVLANFLTDFVLMFRCYIIWDSKLRIVIFPMILSFMNNLLGFSAVVILLNVFVGDVDPVSERTLRNFNAANRMLVAFFFINVIPNLLITGMIAGRIWWIMKKLERINPDVEAIAQIRKRYRSTVILILESGLVYPATLIVFVIVLRTAPLAPSLYPLVSTIAGMAPTLIIVRVQLGVSIKSLDEYENQTRLTTLNFNRSPRSCSTQPSEDEQMIQDISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6F6</accession>
    <name>A0A8H5C6F6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000241">
        <property type="protein sequence ID" value="KAF5335446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6F6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5335446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56066" checksum="B37B900B124057F7" modified="2022-01-19" version="1">MYQHLITAAAVEKIKSKACKEDALAWWNWRFLRKVVFLKVFLFLVAIVSFAVVGIDAELPSDSLRLICQISTHQTFQYQQQHKMTICLEDFARGLLVELRNFSAVYILTLPPRCSQRCNPSGWKDKRHIPQIEWITGMRWQLWEAPGPIIKPAEQVAFSFWIFSSIRKCKCASYVFVSGVGSSRYGGLGIPSYDYGYDQGFLLLTPESSTMQKRNLQVTLVEEEVRARDLEGEEDEGESTEGDDGDGTETEGEGNSKKRHQYEQDHVDSHIYLHLDAHSSHKKASKLSLKKKPTKTLGSDDASSTNTNSASSSPTTSSSTTALTRRPSLKKKKSSSNTKGTKKTLHLSPSTLTDIYELGTGNRGSVMKVKHIETGMVLAKKVSLSVPFFVFISVVVAIVGYFVGIIVDMGTMGWLPFLRCWNYGLGICQNLCCGDYEVPLELVLKAEMCCCLLLGAGLGYFVNKVTGAKYIVTSYGAYLQEPNICICMEFMDRGSFDSQVQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9Y7</accession>
    <name>A0A8H5C9Y7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9Y7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44632" checksum="EE3C135530761726" modified="2022-01-19" version="1">MASFLNALLNFRLIGFSVYTIKHVCSNQRCELPTAIFLKTSSIQHILQVLAIPCSESSSGFISDALPPKPKWTTKDMPYMSGKVIIVTGGNSGIGKETVKALLEHNAKVYLAARSRAKAEAAIEELRKETGREAIWLQLDLADLLSIKAAAAEFSSKESELHVLFNNAGVMAPKIEDVTAQGFDLQFGTSVLGVEPSFITLHGHFYFTKLLLPILLLTARRSPDGKVRIVNTSSNAHTGCNKLNHESFWDGAVRRKMSSYSDLYPQSKLANVIFSNELARRYGDQGIVSTSLHPGVQATDLQRTFPKPVKVVMDALVFHPAAMGAFTQLYAGTSIEGTGLNGKYLRPWARIGKASPASDDIEECRKLWKWPRWKNKLRRLSPDIPGISLEPFSDGSSKYYLFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA92</accession>
    <name>A0A8H5CA92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA92"/>
    <dbReference type="OrthoDB" id="3022400at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="526" mass="59708" checksum="9C3E4520B5EDCCD0" modified="2022-01-19" version="1">MPIQNFDILGSLRGNYGTYTTDVHNALKHLEDAEREVKRCSVEAKGVALQNEQRSLRREIGLLRSLLTPIRRLPPELLVLIFSLVCVKSEIMRAVDCPPIRLSQVCAGWRELAWTTPILWSSFSIGEPNIQLQRKYDQFKEIADLHLRLSQQCPLSIHVSFSSTYFESNCETLRLLMAHSSRWAVVSCTIDSDYLFEGHFAPVRGRLPILRSFEMYVAGGPHYSQIGPESMIQDAFHIAPMLRDVKITGVAPSHIPLPIRQLSHLHISNTTLGAAFDCLQQATAVLEVTFSYRLGDSYAEDEEFETTTLYPISLSTVESLTIITDEADLVDFLQYTTLFSLTHLSIKAPSLEPVDYLAGPRDAIKEFFARSQCTLTSLSLRTVHIPDIELIALIQTQPSLISLSIHERTPHKVEDHYIVLTQRFFHRMTVDPTNVQSTLLPNLKELDFWIYTVSFPVASFVDMVRSRWIPDYKQTSAPGVDCLQSVTLCVFGDTKQLEKDIQPLRELVGLKILVMEEDNVWWNTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEQ0</accession>
    <name>A0A8H5CEQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEQ0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="27612" checksum="5397C4B8623D7B38" modified="2022-01-19" version="1">MSIYQTSYPELPLWQAGADTLLILKPYQMPVLLSLFALLVQRPALVTASTKPKNLLAAGYFLAESVCGPADSPMSDLVNLSSMTALEEATFGDYKKGSVSMTFESSNNSALSGSAADAEWDSFFPKNKGFISQDIENNTVLYSISGFHAMHCLDTARRVLEVHYNVASDASKNKVNTDAIYGSFYHLHHCLIYLREMVTCSADPVLKHIYFANGTASFGGDGTKHECRDFNALYNISDQSHEAAKMACGGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG28</accession>
    <name>A0A8H5CG28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG28"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="276" mass="30194" checksum="20DA822606D6B8ED" modified="2022-01-19" version="1">MQRFGLQFSFTIEKGELERTPVGSHKRRTLSEPLPGASRVTPHTMIKLQLYTVLLSLFALLVQRPALVAASAKPKNLLANGYFLAESVCGPADSPMSDLVNLSSMAALEEATFGDYKKGSVSMTFESSNNSALSGSAADAEWDSFFPKNKGFISQDIENNTVLYSISGFHAMHCLDTARRVLEVHYNVASNASKTKVNTDAIYGSYYHIHHCLIYLREMVTCTADPALEHHIYFANGTASFGGDGTKHECRDFNALYNISDQSHEAAKMACGGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGQ0</accession>
    <name>A0A8H5CGQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_013554</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000176">
        <property type="protein sequence ID" value="KAF5340448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGQ0"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034408955" description="CFEM domain-containing protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5340448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="101" mass="10508" checksum="781202980F798E29" modified="2022-01-19" version="1">MRFSTVFVCSALAALASATPATHSFQSRALPNCAVSCVTENNPSACSATDNVCLCNNKEFLYTTTNCIENACAHADITSGLEEVKAICGSVGVPLTFPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CIL1</accession>
    <name>A0A8H5CIL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000169">
        <property type="protein sequence ID" value="KAF5341272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CIL1"/>
    <dbReference type="OrthoDB" id="3049502at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="409" mass="47169" checksum="A66FCFA25D3A27B2" modified="2022-01-19" version="1">MSRRQTDPPSFPADRDTASTRNQKQSSGNQPLWTSSNTARDDALGSSRRQTQSSSSDSQPVHTAPTQPPAHLPAGAPAHLQRNGYYSTSMKVQVAKTAAYSYFYNRRNTENPLHILYGIMFTELTAKDHTLLPCVQYNLWLKDHDEKLPLPEALYAMGYGHKQEDVRCDDRSSEKSNEDEMNLGYEEEDEDFNEAANASFSSAHTESGTSGDRFPDLALLHLRLIHKPFSPRVENPKTAADFSRNHKHGVRWRHRRGIQIIHDCVPFLCELKAGPPRQLDLQMDESSKVEHETMLLRNLQYAHVDLAEYVVWCFAKYPYLEEIVAFAATGVYWQYVVLKKHHVKAEWYDWTNKKWKDPKFLKEYYARWPKNYYEVGTKESDAVLDEMYKTHLQPLCSFGTLDPQTVMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL50</accession>
    <name>A0A8H5CL50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000152">
        <property type="protein sequence ID" value="KAF5342931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL50"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="23160" checksum="0159C13ABDFB11BD" modified="2022-01-19" version="1">MDETDNPLGTLPPNIAELIQAALSFFIQRNMGSIYVMVIASIWLGVSFSLFMALLYTSTPCSRRKPIFVLCVNAVGFGTIPSILFLKLLVQVFVRTGNATLNVANDVKPYVLSLSFFSFFASLSVDSILLFRLVAVFPPSRLSRNHLGLTFGPLLAIKMGRIVAIVVCVINFMKRARTLPSYDPVNLFLAIRRMPEPKAVWSLQIVDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLA6</accession>
    <name>A0A8H5CLA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000133">
        <property type="protein sequence ID" value="KAF5343820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLA6"/>
    <dbReference type="OrthoDB" id="3014170at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="370" mass="41307" checksum="0872C3B7A3208AEA" modified="2022-01-19" version="1">MAHINSFNNSSGHRIEGSTINAIGGNQHNNRAGTQFNNNSNGPQNNNNGAGTQTNYHADGAQRIDNGYVGKVEGDFRKNEQNDLCDGGGGLAENPLEAGNHRENLPEDMKAAFYECFTPALIELAGCRAGRSGTWSEPTPQELKELWSQVMPSDIKNGFSAYERGIKPLVTKVLTDWRNSFGEAAIKALQDELDMLDVEPQEYINKQTKGNIWEHPCYYVQPEQRTGFLQTNIVAKTFSEHFKAIASIPVSERSGDPPKRAMVLAILAVTLFLLVYYLNRWAIFQIERAFRIFSTTTCIPPSGEFSSDSEAMKLAPRVFTFFEKNERGIDRVDSKLWGKIIAAAESHLEPTIDAGDWNEVRYKELPAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLD7</accession>
    <name>A0A8H5CLD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLD7"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="98536" checksum="E61A75548E085859" modified="2022-01-19" version="1">METPSLPRARRRQRELEDDGSQPGPFTAKKRRSQTPDSSTGSAIPIPHTTSSPSPRLFPPPELQHADCYEPKNRFYHPPRQRVPVPTVGANGPIQAPASNPGRPNRPLRGRPRLVIKPVRNSRGVRRSQATEKYKEKIARERAAQQAAQIFRRKPLEIKRKQEMEAILGAQKLVMVDKAHAIYRNLAKPENEGGYGFKSAHEFFDSERPEKPRSVTFYDIICRTKTKSTGPSVEESSAFDQTRRDLVTDLAVITGKLHHSARNPSILGVLVECRDAYDIYEKFQSRTWSRRRASSFRTVTTENPTDRDTSCRPIHSRALLHTTVSIGLFCPLIICQMNPSTTLGRSVTSADRLQLEDMNQIFNMLRSNHTVPCSGISQCLAAAERDIQGVLDQIHQLEKRIFTLKDDMRGLEWRTFRYRSLLSPARRLPAELLSYIFEAASEDGAIIGATMRSTPAHISQVCAYWRTLARRTPKLWSSLDICPQPSHTVEQIKPLLTMHLELSKPSPLYLTVDMKSGDSRHPTNEVASYVLQNLVLHCDRWKEARLRGLKGFEQNLSAIKGQLPSLRTLSLKTDFAPDFDALELIPKLQQLRSHGSSTTALPWKQVAIYQAERMNPSDVLQELSNASNATEVVLTRCYLKRPPESHLVHHLHSLTIFINSSRPNFSPWFQWLTLPNLTRLDIMADKKQAPTSCNSVFLDDCFPSFLMRSSCTITSLTLRNLPLSDVDVLAILSALPSLSTLEIKERDTEPSSNTMLTTHFFESLTIDHGQTFSNRRSPSLQLKRLQFLDLRLHATLPAQCIVELIESRWTDDPQYSAVLGINNLSEVEILVVRSEDATTLDVQELRDLMKVKDMGMRFSCSSKFLKAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLD8</accession>
    <name>A0A8H5CLD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000137">
        <property type="protein sequence ID" value="KAF5343623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLD8"/>
    <dbReference type="OrthoDB" id="2507562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21551" checksum="96A64A30FBB98407" modified="2022-01-19" version="1">MHRFWHSQVGLAGLMHKSLLSPMAKLPKSPIAALKNGLSILQKNIKARLSRKEKVSIADEEWLDNEANVVEEEMVIEKLEKASDYELAFERLNSKENEVVKKLMELAEGEVKTVSKKRKAPVDPKPATKKTTKDTELKFAPGQRAKLAQKITVLEWYRNNGKNQTQTAAHFGLVQGTLSRWVAKMDFLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMS5</accession>
    <name>A0A8H5CMS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMS5"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="692" mass="74470" checksum="7C2E94350DFFC94B" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILLAWLQATGLSSVLSTDRPNDAEVSTASPLSAEDAAAQAEAITAAQKKQADWNEKNDKAMGSIKLRLSPPVRQKTLGMTTTKAIWVFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAAGIPTDDPSGNSLTKITNFLIIMFIISKLPPRYEYLINMYTQCSIQQVDNQNLDDLQSEILNIWESRQGAFKGPSGKAQANRLSAVKRKDGNPSFQQQQQQRPSGSSSGANGASGSNGNNKGRGKGKGKGKAHFRRGGRAGKSEQAKRQGQAHLAHGDMSPMMHTVTVVDTPAAVDTRTKRAINLARDIGTRPSGETVATLEDVVMSHPDLSSFTSLTPAPRPKRTLTERIYWNNLQSSSDGWDDAGNWNGWNGEYPGTQTGSDANMACAQEEDANSNEDTLVNTSELGSVFGSTMTESGAKVPQDTRTPVPLIDRLAQDPAADILQCAMHLGERFQNPEDSLHIYGERLRAALNTVAPTGTLSLAQRIAAVRSEMPSGSLPAHPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGGMELPSRAPTPSSMPELRSMSPSLSETSDLEYMSTPPSLGRMSLPTSPVEATWSDGLPSPRPSTPAMVTVNAANNYGWSLDSEVSGMDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNK0</accession>
    <name>A0A8H5CNK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNK0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="545"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="915"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5345020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120724" checksum="5D3AA731170FF245" modified="2022-01-19" version="1">MSSRAIQPKYEFDPEGHYADPQVQTWAKYYAEGGQDTAGAEYFISVPGLKLNGQQTSASPDGRPALTIDTNLQPSQSKLPIPPSRDDFEYLRNTYGVTVADAHSSSGIVVKCDFEPSRADEVAVNAGDIVCVIHRFQDEWSLVRNQNGDRGVIPTDCLLLEGSSSILKLPGPRTPSSLSRLTPLRSPLSDDGTKRKSKKNVLGLLEFLHLTKRSKTKELEDRSTTLASTVETTKQSLQSALKTQSSSRGKESDRRVRFHSPSVSENLGTQSSTSKTGSDATLPILWNVTSDEDVSDCSPISPQALPPRYEEVDSLAVTRASSEKHFASTPPYTTSPFRTNRVSLDSKPLPLGDDKVDLNAVEATTVAPSGTNVVVMNSVTVVTNSTLLAESIASQSIIYRNMLSFLFRQVSPDNSLWGTLYEYYTSLQSLDSVSSLVQSHDYRANLLQVASALDISEEVNIREALQRDENEIAGVLHVISETSRRAVLALEGDDAQKFLDVVQDVLDKGYLLNGEETARARRLLVRLSETCDKLPSSLFIKGVERPDEQATFGGGFGDVYRATYNGQHVALKRMRIFQRDPGVPNVRRRFCREALVWQHLNSSFIVPFLGIEFLRFVSSSVFLTFLAGLGIDAESFPSFLCMVSPWMSHGTVLKHLADHGRAGVNKRLHEVTQGLAYLHSQKIVHGDLRGSNILINGNWQACLTDFGLTVFNDATAATFTSRREGSVRWMAPELHVPEHFGLDRFRLTFETDIYAFGCVCLELYTGRPPFCTQQHTQLPDSAVMLKVIQGVRPERPTGEGEMSDQMWKMVEMCWSQHFADRLKTDEVVEFTRGFSDPNTKSLDLPVFSEVPKSLLPSDDDWDDLDLDPQQDKSLPIQSPLYLQEGSSLSTLSIERLPPFPHFPIRPFPAYPPVPGQSLTVYSDGEDETTENSPGDDLEYADHDSGDSSEEDVEDGETEGVSKDDLKHAGFLDEDKEAEVKLDGGLKGAGKKLDNLDDNSEVTLSAELADYWDLVEVLDVALNTNFSLTLSEESEMSKPAVNIAEPYLPSVSPVITTLLTICFAFYFVLYLFVLVYLMLAGLLLQPVVIGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNS1</accession>
    <name>A0A8H5CNS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNS1"/>
    <dbReference type="OrthoDB" id="3333333at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="71"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="921" mass="104330" checksum="6BEC6B0453F2350E" modified="2022-01-19" version="1">MMEDKKLTRTSSSGKRVIDGPVLTQTDLFLLNCPLELNPILTQTSASFQLVFNIVTGHTGGFNPEARDRDLPFTSKDEPATIPRVNQLMIITNMSPWCTIVKNDEGVNLGDICTQIWKDYAEGWCTDGEIASLPPRLQEQVKRASAARTQGWAGGYYTPAAAPTRHKRIDWLRDRIFFERLHKEDNYAASRLGFRAPNIFQYTLLLVIPVCSESPCTASDLLRASFQRVLLHVEVYVRKSEPQRKKDATHPQTVQAINTVKIDLARKYQSWRAGTSSNSSRLIVFTQRNNICTTLLCSGGSSHHLIAYGPARRDCMVLWSVFVRAKRELSRKGTKSKISSSITPPRTFHLDTSSVLRTRYSIADFDSLIPLQATHNVSFGHLDTSGLSKHFVYPITHYSTMPPKHTLSFIPRVSLNSAPILEQLRYPYQLSDPAGDVDRILRDGVLDMDDYERELLALRAKMLSVENRRQMLKKHMDLCQSLRSPIRKLPVEIMNIIFSLCVTNKFGEHWGYWNNYRGENCLTARWPTLLLSMLWCHLAIREKANTALRSGTHPLAVDIDLYDCETRFASLIQESHRWSYLRLTHVGDERRISRFEKLISSGALTQLKTLKVCSENASPAVLDLFKGCGQLTSFSTDMHLFRFENYTFPWSQIRDLELRAIAHCPSLVSLHLDCESWNYDKIEEPEVEFPELDQLAQTSHSIRHLKITLDGPEIAEKTRDCTNALGFLLSCLTLPSLESLAIAARSYCTGSLFDKGENWPTKEVEAFFHDLTADQSYGDQSDRTLSLRLIKCLHTSDYDSFSSNSPRVLPRLQRINFTIHGSNSQGDGKQGDLFDDAAFLDMVRSRWVLEDLGPEDSGVACLKSVAFHIVGRPMRPELGNEVRLLEEGGLGIMVSHYETEEEEEEEEEVQLGDGAQNVPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNW9</accession>
    <name>A0A8H5CNW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNW9"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="363" mass="40707" checksum="C5BC9BABE92D1D68" modified="2022-01-19" version="1">MDSDSFQFIIESPQHTQGHKKRPRLVTSCDNCRLKKIKCLQPSPETKCEACKTAKIPCRFRDRERYFAERSRAISGPSSSPNYVNEMQRNANTAPLEGFSVASPPSSRSSSSYTSRSPKPSGIVAPDDSASVRYAPYGSETRRSVDYSHRASYSNSSARQSPLSYGSVSPSPAPMMHHHHHSRSSSGPRQSSIFDPDNNQFPNFQFMSQFITLFFQHLGNEYPFIVYEDVWSDFMERRLSAPMANSIAALAVQYSVLPELTVRGPHNVAEAYVECARNAISPVAHIPSVDTMHACMLLAWYEYRLGRYSAFRDLATTISRLSTQLGFTAPHGGLITTQDGERRKWTLKGLYSINMTLANPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPF2</accession>
    <name>A0A8H5CPF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPF2"/>
    <dbReference type="OrthoDB" id="3066951at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="211" mass="23809" checksum="17431BA352E6F09A" modified="2022-01-19" version="1">MDSSVFTFTQLSPPSPFSSLDKKQSSPLARWKRLVKQVVRTTTPRINIIDILDEARPGRPLPNLPPELWIMILRYACLPPEPRTRSAAGEDQSFLDTPSYYLPSSHPHYTPSSSLPPPSPLSRISSNTSDNNTSSNTDYPYPTSASLNPHRTSPAHHFYRTLMDQKRSFALVSKLWNAYSQPALYEWVWLSNKRQAKALALTILCQVVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPM7</accession>
    <name>A0A8H5CPM7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_019051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000120">
        <property type="protein sequence ID" value="KAF5344693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPM7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63637" checksum="A4E8E867D35FFC93" modified="2022-01-19" version="1">MQSAKWLFRQLSELPLSNMATTEASKDAFPCHWHQLLLQLPLHTPTSPPYTGFLFRMPKNPNRQRLTLPGSLGYVLLTWLALVPLLCSDALSQSDLYPPVRNHACLLSKKLPTHWKEFIWINITKMASRGYVSVDGDTVKLCHQGNKLLELALPSRKAEDLRIQPFWNHFVRTVRNSVPRLPATLLPTLRNSASQLPVELLLLIASHFETIDCLKAGTLVCRGWVKVMSEELYKRGLCTLSWHNLRCAERQGVLDKQLKNAANFQRLSVELPLCRYSVTSLTRITYLELSGSMVLSKHILLTAKLSFKNLSRLVLRNLCGQLEAWTRLLQGINPRKLKMLTCSYCIVLGHPLTPGDFADVAPGHLDFDDLALSINYCYGIVDILEHFSVTGTSSLSITQYLIEDPIVDFLNQQASSLKLLAWHASIPNATQINFGAMHQLECLSILGTSIQPSVPLSIRLKVITEMACTSHLCELCLSMETFHATECLALDDALLNLLEQRPLSRITIVASYLYDPVDPNTATLEQFVPRTWNVVGGRLSFRRASDVHNELVARVNGVHSLHVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPW8</accession>
    <name>A0A8H5CPW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="16" type="ORF">D9758_013037</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPW8"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000019">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="175"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="778"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="891"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="919"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1100"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="620"/>
            <end position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5345690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1205" mass="130133" checksum="BF58B12BF97DF6EE" modified="2022-01-19" version="1">MNRVTLASSAATLTSLSTSPRYSCQRRRTLLSSFSLRSFSPSSLASSTPSLASRRYRTQCSPVGSTTHPMHPRTFSQSFSAEARSTPVLGYPRWINSRTRPGEEAALDEKDEGQQDEKADSSSSGEGESESPPSSSASPPSSSSPPPSSSSSGSSSDSGSKNIAKPSVPENYPQVLALPIARRPLFPGFYKAVVIRNPHVVAAIKEMMKRGQPYIGAFLLKDDKEDADVITDLSKVYDVGVFAQITSVFSANAGSDGSNTAPGSADEGLTAVLYPHRRIRITELVKAGELAHAEAKVEDVDAETPTQTETPPPSPVLEPSEVAKPASGAPPGSIQTSFLHNYPISVVNAVNLQTHPYPSPNSKEGSQSQQSQHIRAFMSEIISVFKDIAQLNPLFRDQITNFSINQVASNVFDEPDKLADFAAAVSSSSGDTSELQDVLESLDVADRLRKALLVLKKELINAQLQNQLSRDVDSKIAKRQKEYYLMEQLRGIKKELGIESDGREKLIQKFRERVDGVEGDPESGLKMPEQVRKVFEEELNKLSALEPSQSEANVTRNYLEWLTTLPWGLHSPENFSITHARKVLDEDHYGLEDLKSRILEFLAVGKLRGTVEGKIILLVGPPGVGKTSVGKSVARALGREFFRFSVGGLTDVAEIKGHRRTYVGALPGKPIQALRRVGVSNPLILIDEIDKIGRGHNGDPSSALLEMLDPEQNDSFLDHYMDVPVNLSHILFVCTANNLSTIPPPLLDRMEVLEVSGYVSEEKAEIARRFLGPQAKVSAGLGPVTPTTTATASSSASESHERKGEVEGKEQKDEGKEQKNDEEKFEGATATPALAQAISTLKDGADVVLTDEAIDVLIKYYCRESGVRNLKKSIDKIYRKAALKIVQDLGEEVFPEPEEPKPTTGADKENAETDSANQDTFTKVTTDSTTPDSNDPTAPSTTSSSSSSSSSTPSDPMATEKKKKKTVTSITRKPMNIPSSVHIKITPENLKDYVGPPVYQKDRMYAKEPPSGVSTGLGYLGNGSGAVMPVEAMSMPGKGSLTLTGKLGEVIRESAQISLSYVKAHAFELGITKSKDEGFLEGKDIHVHMPEGSIGKEGPSAGTAILTAFVSLFTGRRVNGDIAMTGEISLVGQVLPVGGLKEKILAAHRAQIKTIIAPAANKADIEENVPQSVKEGIKFVYVEDVKEVLVEVFGDDIIRNTEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR29</accession>
    <name>A0A8H5CR29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR29"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23828" checksum="70EBCC26EAC6BFE9" modified="2022-01-19" version="1">MRLIGPATPGFLATLAACVLLGIVSFCVPYFKSVFFLKAGFQANGQNGTITFGTLGFCLELGNGTTCSKPQVGYQLDINHLVGDNNPNIQIPQIAVRWLTYALVLHIIAFCLALLSAVFGLLAHVCELIGACFSTCISGFTSTITLLAFAFDIALFTAAKSRINHVDSGSATTGNAMWLTLAAFLLLLFTGCFYAFGSCCISSGGSSPRRKKRQDMEYGKISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS59</accession>
    <name>A0A8H5CS59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS59"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="14356" checksum="A37DC072A03813AB" modified="2022-01-19" version="1">MTIVLDFEELETRDSVEDEAHVEDTVDVVLDRISPMVSARRHIIPSSHSLQSVTSVAALQQFRFCAQRALPSSETVTKWLSNFHSTTVPRLCAFAGEGFELELLTETRYIILGSGVAAVTSVMWAKCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU57</accession>
    <name>A0A8H5CU57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU57"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="191"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="463"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5348064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="86276" checksum="6B0F925C800B151C" modified="2022-01-19" version="1">MPPSVTTEDLDYADLPIIDISRADTPEGRADLAIQVSKAMENQGFFYVINHGYTSTQWFRFPMQQTARIFDIADALFTQVSEEEKRQPEHVSKMKETGSAQGYKPREYIHIDNGVRDQIEMYATHRDVSKYKHPKPVRPLLPEISHFVKHSFFNILHPILRLMALGLELPEETFVDLHEFDAVGETHTRFIKYFPRTEADEEKTRGVWLKGHTDIGTVTLLYSQPVSALQMLGVDGRWRWVKHIDNAIIVNTGDGMEFLSGGYYRATVHRVVQPPKDQRNVPRLSIGFFGLPNDNVKLGPLMDSPVLQRVGVKQHGRFQSDAEIPTMETWRKARLSTYGLNRLDLKVSEKDRSIEEETNTWADDGRIPYTLTTHIVPAAYWRVDPDVELPQTSADHEGGRSFKEQRKKLVRMGEERLRKLWTEADEEITHLNGKVGSRGQTKIMWICLNRYIRTGPVEGGNVLFFAHATGFPKETWEPTLLSLLSSPRAESQVREIWTWDAVNHGDSALLNEGKLGSLSYPSIERLPTHLPRLPAKETARRLQKGFPDGIIGVGYSYGGLVCHSSRILIDPVIGYPGIYSQRPNTLVLGALARRGVWKNRNSARQDFLRSPFFRAWDPRVLDLYVESALYDARRDGDGTQAAGMVVRLKMPPIQEVNVFTSAPSAADAWVRLWRGELPERVALRWIVPGEGQIELPDTIPTSDGITPTQVRVWLRPSNSSNVRMDGAGHLIPQERPVELGLELQQALLRPADRTEASVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUQ6</accession>
    <name>A0A8H5CUQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUQ6"/>
    <dbReference type="OrthoDB" id="3217196at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35910" checksum="A7656BDECC4CD58D" modified="2022-01-19" version="1">MNLATILCLRFDHTHEDRDIEEAVQIYQDILPSRSENSIPNRLTCLTKLATALQSQFEACQQLNYLDEAIQYWREAVEKSRSPPVLSSLLDSHTSLADALYRRFDEVSHIPDLEEAIALHHFTLSLRRDYHKAEDPSLHSLGRCLLRRFVHTSNTNDLEQAITYHRRELHCRPAGNDSRPSTLEALASALCHHYDIHGTQDSLDEAIVLYNQALQSSLDGRHNDLRVLCLSGLGAALHRCFDEVTGSTQDIDASIANHRRALELYSPHGRLRYKFLSRLAAALLSRIDHSGLEEDIHERVSLHCRIIEQCPPGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWP2</accession>
    <name>A0A8H5CWP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000081">
        <property type="protein sequence ID" value="KAF5349384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWP2"/>
    <dbReference type="OrthoDB" id="3266532at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="558" mass="63474" checksum="83247C06EE68DAC3" modified="2022-01-19" version="1">MIQKIPNFSFFQNASYNYFQGSTFNAVGHDQHIQIHYGQQISQHIRQNNPIDNMPKALKALHNADAGQGQTRKACTEGTRTEILSAIINWAMGNSTIKTMGYWICGMAGTGKSTIAMSVCIELEKQNLLGATFFCSRQIPECRDHSLIIPTIAYKLASHLQVFAATLVETLRNEPEVFSKPPSIQLNLLLINPWNQIARTNIQPTVVVVDALDECEDISSVLSALIPAIHNQMMPGLKFLFTSRPERYIQKHLRIDRPLSYGSEVDGMFLHDVEETLVKEDIMKFITAEFKELMIPGKDTYIKELAEKSGKSFIYAATMVKFILARPGLVRSRLKEAYSQTTSRKHQTQILDDLYSHVIKTAIPRDYLSLEETGDCLKVLHTIILVGRPVSCLIISNLLELEFTMVEEFVKDLQSVLYISNSDSFIYIFHTSFRDHILTESRTEPLYACKPWEHHAMLSRRCFNTLMKLKFNICDLPSSFLADKDVPGMEQKLKNIDDTLRYACNNWGYHLSQSDMGTGVVSQVKTFLEEKMMFWIEAMNLIGDLLNCSEIILSLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYD2</accession>
    <name>A0A8H5CYD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYD2"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034503461" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="73"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5350237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="40140" checksum="9BCB2FB26B2A1836" modified="2022-01-19" version="1">MFGRLLTSLVGLSILVTVLGGPVTLDKRVPMFDQNITAPHPAPKVVSREPMFDQNITAPHHVARAANAVPSAPRFVVYADKFVPGQTGPPPVDQVKGYNVFALSFLLTSGPFDKALEWTQLSDADRASIKQQYNAAGISLVVSAFGATDAPTSAGADPTATANTFANFVKQWGLDGIDIDYEVGKNLTFPVFKRMLNRLPQDFNAFNAQDGSAENWLSTFTTAIRAQLPQGQFIVTHAPVAPWFSTAKFPRGYTEVHKNVGNLIDWYNLQFYNQGTTEYTTCDGLLTTSSATWPNSALFQIASNSGVPLDKLVIGKPATSGDANNGFIDPSTLATCANQAKSQGWNGGVMVWEYPDATASWIQSVRALAFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZ86</accession>
    <name>A0A8H5CZ86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZ86"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN RSV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="743"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5349846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="984" mass="107018" checksum="54C41B2C2213715C" modified="2022-01-19" version="1">MAAMVASSHGPSLPSVPSSTASFTSSQLGKRCRPAPPKTFQCRGYGDCKMVFSRSEHLARHIRKHTGERPFACHCSKQFSRLDNLRQHAQTVHADKQDANERMMRELTSLHATMAAASKAGTGRGRRASSNSSSMMAIKREPSLYDDPAMSSSLWQMPDENDVDMETLSMSQRSSPAHSPSGNNQSFRSITDDLSQSFLDSKPPAPSQSFRDREPRISNINIGLGADQSFRSSSLPVSASNGRTPSPHHHSSPQTNSPTSASTSTSPTSYSHSRSPYDNQSFPTPSHHTQQQQSQSGYSPYSQLPVDSPNSHDELELFKYDPYDRPLSSSGAGWRELAEYAGTGTSAGPGADASGSGSSDSPFSFNVNASVGGGPSGTTSAGNVVGGSGSGASGYGGHGYVEYGYGKLTNTLEEDLTRTSPKASTTTVPNHDPNLDDLPFWNYVESKEQTMPLELQIDLRTKGKHDKPEDRAKAKQEKGQKGENREQVQAASYSAELVRQQKEQMLKMKESLQRQKPPSRPSQAPHPPSQSQALPHPPHPQQASLPTSTSLGPHTQHPHPHSRPRIVHTHIQTHTSPIQPQSQFPLGLVEGMDTVDMDTVDMELVDMDMDSGAMESSRDMDLEPQSLAMAEAQFSPAHTPIVPSQASFLTTESATPQQLQQQPQPLRFRSLSHHDAFEEAKGLGRLYANANPAHQSLLPPHSPLRAYSDFVNGSGDGFQAQPGAVPLVRDMQRQRRQMELAEAYQRHRQREPQQQQIQSHNLHSSSTLSHTHPYLHPHPQSHHIHPHTNPHHHPLEHRHQSPPQTQSRLRPRQTLSQTSNPNHNAILIQSQTRDQTGPHHQYHHRIRRSMSMPMEHGVGLGGVGAHLGIGIGGGGRSGHGGIVGTSSMNAMMGTSMHRRPSQPVQTRPDMDLGMLSAGVNGTLGDMFSNPSPNRVPDSFSGVGPGLGFDIDSVSGSGQYDIDAHALQGLRFEGFENGIGSGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0F6</accession>
    <name>A0A8H5D0F6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0F6"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1171" mass="132531" checksum="E2A4078D2894269F" modified="2022-01-19" version="1">MEIGIGGDKNVSQRSREMVTIDDDEKWLTFMGLELAEEDQYDNLVQRLRRSRRDYGDSEDHDNLNFPSSVRNAVMSIDTQQSFWQLNCKHGQENNLVFDIMRFAMEGEDVKPGLDYLESTPGPSEALMPPSTARANKHPSYSHLRTSSSIPLSTHVTYDHTFFTTSQPILSPPNSSRSSAQAPTILPATHGDNSWSPWVRKALKATKDIEEFALSSDGNNGLFADQLAIDLELPSLPSLWLRAIDSTSLDPDETPEHRQNRYLQENRPRLLEWIVSQDSTVTLSALTEWLSSENCTMSSPAPSAYVIPSPVLQRSQPDAHGIVPPGVYHARIFSAFAVAGLSGYICLEADLGKYPQETDVVAFLRSHPAVPISASVKQRHDAGVSRAWVRMCQLTKNQVAELLSWRPPPDIRPGQWVRITKGIYSGDLAVVVRQEHHDGQRRLQVLMIPRIVPPLLADWNVSVTAFKNSQRPAQHLFSIVEFPGAKRILTEAEMNEDTEDEIDESENRVDRLARLKKQEWTKKLACQHFVWDEDQFHFGLLQMSVPYSSVSILDITMDKHSRILFVTSGHPYLGRMDFPDPREWVFFANDTVRAVREAGRTSVEILPPVERILRKGTVQSVESHGCRVHFSEYDGFDEAETAVLIPNGNLLKTFKVGDLVQVEGGRHKGLLGWVVSHSDIQVKMVLWHKTPDAPDGEDIEVHPNTCRLQSPRAEFAVPWINTHVLVAAGKQYKQHTGFVVDVSMSRKGYTMVHVDIPMAGVTAVLRHDDVVEHQSKKPLRQRFPLQAHQMQFRQLNWTDGSAEHIVPHQHTSSYSTKLDSLPRAPNLKVELDQDSWEKPIYDVHSGEVLTPENSLVYQPPVCPWVGKQDVSVIKGPTRSLGTVKDVRRDHLRPSGLTIRVELYMIHIERGGNPCIEVDYTWVRDHQTGLSLAARYPLWSREAYWEPLVYVSPVKPAPLKPQNTLPVLPGPAFELGKTPPWRGSESTDEMSTATNASTSTLSTHWAVDSRLHGKEFFARWIPSKGPGEPKVVAKPNSRTGLVRITDRNGWRDVPPNEIHPLEGHLNQSHKKNLDALLVVHGEHTGKYLRPFYHDFIDVEGEKEQQLAIMAVEFCDWGEDIENRMEGFVLVRPEEYAKAAGDVNREQFKAEIKRLHDEAQARNKRPRPRVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0K0</accession>
    <name>A0A8H5D0K0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0K0"/>
    <dbReference type="OrthoDB" id="3234968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59106" checksum="67585A1DC463565E" modified="2022-01-19" version="1">MCIYIHFSTNDRYSFFFCSFCSFSSLEARRSLNLEAFLVLYICSRRDLKAPSLRPTVSFYLMNQLVSYFFLLLAIWNTASSGALVNVTVEETSPMVVYSNDNSWYKNDTNNPLCHDNSHAYSGNPSATVNLTFKGVAVYFYATQWTRNKSLTLQLDDGEHTTLDLTDDERYDPIASIQMTKSSAIVWSQTDLTESEHTLVVSSARSVGFSMFNNFDAVVYTLLPLPSIAQTDGQYRYIENQTDSTLDDPASMMRNQTADSQSFNLTYFGDSESWPENSSQTLSRNLFQAPLIRYSQNSSEKAVFTFKGVAIYYFSARWPSSTDAVVQLQVDEDDPELIDLTDHASVKQLSPDLSKPTVESSIVWSRTNLSNAEHTLTIGSGGTFAIVDTLMYTSSENNSSNSSNPSTTGTPSGPEPPDSTGPQHGSHFGLIGVVVGGVLGIFALAATIWFLRKRKQDKSKQLKGASGSMGISPFMSRGYNVTTESSSRPYTDLGLFMPSQTPHARGLRRKGGLGSFGVVRNVISRDGTLPPPYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4T9</accession>
    <name>A0A8H5D4T9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4T9"/>
    <dbReference type="OrthoDB" id="2690041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="846"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5353139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="998" mass="112174" checksum="E7F7D11DAA2C95C7" modified="2022-01-19" version="1">MFPDQQQVLKADQSGSPPTTPLHIRSNPDRQSPPEPPIFQSAVPFQPSSTPSTLFYQPYTSHYHTALPYGLHPQYQQWPFPYYSPNPTPQPSRASTLLTNSTPVQANFITWQPPLASGSQSQASSMSRKRSAPTSNPPPSRNVHARQSSDKENHVVPRPAIAPTPTATISGAGPIPNPSFLAPSPLPPALDSSIFKSVQAKQKRSDSGSHGAATDCWYFMVPADTDAIPSPNPNLKPFATRPKGCKWLACRLCPEGNKVGTFQNVSGGLTRSIQQHLTKFHGPIYNEIVPKFKLKGWDSLESTPTILKYFRHPGEEFSTTVFMELLVRWIVVDDQSINVIECPEFCDVLAYIGLDLAPNDIPHRTKLMELIFSQFDNEFTNIKREIQNSLGRISYTSDMWSRDNLEGYMAVTAHYFIRKDGHLVMKSRLIAFRHIGETHDGETMAKYFFTVLNELGIARRIGSITLDNASNNNTMMRALEHMFREIGIQFSAEGNWIQCFPHIINIAVKTGLSKLTYAEEPQGFQDPDGVTEADIVDFTPPPAFESISPDYLAALKVNLIARRHSGLCKVVIEIREAVLAEKEQAGIEITEDDENNVIKVVVLLRDVDTRWSSIFLMIDRMFLLYPAIQKFAQLPENDEIHSLLLKDSELLVLNDIRLYLKAFHVIQEAVSGERTLTLSFVLPLYERLISNLKKLRIILPNLSHMIDSSLDKIYEYVDKARSTHIYIEDQWSEQDASNAKAAIINVMTEHRTLMRHEKAQSEVPGRIPIDFGGSDAARALNSGFDYLDEFTESLNTLSRTSSTSLSLTSSLASVFDDTSKSHDTVLSDEEWENEAMLEDHQLAKEELASWIGEGVLQGRIDLVHFWDNSTLQRKFPSLFCLALDVLPAQASAVPCEHVFSSSKETDTDRRTRMSSVLVEVLQILKALYRDDRLNFTKSWVAKPSELGEENDQKYCTESDSSKDGMTTTDLQTDELRDMLVKGQVADIMRLVEASYNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4Y1</accession>
    <name>A0A8H5D4Y1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4Y1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034198201" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="58"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5353747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="357" mass="40153" checksum="F3A5789F2ADD9555" modified="2022-01-19" version="1">MIFPLLPLVFFTLTVKAFSLSTSPVDTPPFNSLLFKDLNVTRGLNYHYYAVPANSGKPTLLFLHGYPSSRYDWRHQVSFFQDRGYGLIVPDMLGYGGTAKPLDPQFYASSLISKDIVDILDAEGTNQAVLIGHDWGAKIASRLANYFPERFHSFAFLSVGYLPPTFFSTPYTQLNALTKAVLGYENFGYWDFLSSDRANQILLDHLESFFDLAFTKDTVKVITDWSPLGAMEAFLANDTRIPTGDYITPEELAIQIEFFRQSGFAAANNWYKVLTTSIEADDNKGISEESAIIQKPVFLGAALRDYVAVAPTFIQSALAFTNNTLTIHEYDSSHWIMLEVRDQFNSDLLQWIEGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4Z1</accession>
    <name>A0A8H5D4Z1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4Z1"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17496" checksum="5FF368857DDEADC9" modified="2022-01-19" version="1">MPLHRLYVPPNLYTPEEKSAIAEAITEVYTGMPNPLPPFYVVVIFEDIPKQNYFVGGKPTDRFLRIVVHHLARQFADDAKKREFLGRYEAAIEPWTKGKGIDWEVQVSDQDPAGWNENGLAPPLPGTEGEKMWLKLNKAVPYEAHTSGHQANGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F0B8</accession>
    <name>A0A8H5F0B8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000441">
        <property type="protein sequence ID" value="KAF5318971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F0B8"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="300"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5318971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="589" mass="65763" checksum="645BBEC42FEA5084" modified="2022-01-19" version="1">MEPVLDVDAEWRNNTQDLTTVVNAEIAQCTGCGQIGRNLREPLCGMCKQLAAPTPLPIPTPTISQSGTMSNAVANSMSTNFTASMQAAKQKQAQMNAISTPAALSPASEMSAFWAGQSGSGRTILIHARLATPEKPLVTFPNDIMTFDANDSVSDVKKIFVDRFNAQWRNSAPGSMQYDEVNLRWPQNVALIGNTEHGTVGNLYDVHLAMDGFPLKNLVSLADQTKKNPSPRQTNGQHIHLWLIVDAPKMETRLGVELPQALGGSARAKRRLDDSEAGSMPSKRNAPLVSSYGKKGSAVLKIKSCTRFPSSTTMKLRIAQIQEQEEGEIDVDWDGGLTKTVFPGLIRVSEQMVFKRMSNPYNMHYDSWALESELRILHRGKFFWDIFKQVCEQDGVDYCKDFSFTDAYLAEEIVEKDTPSTLSGVTADRYMQEMYEPESADLEPLRVIWLIEPRHTTEVTKYSGTMTQVKRNTLPFVTMAAFAHFSLFWSHGKMVFVDLQGSPTEHGQVLFDAMTHTREGDSGPSDHGYEGLEEFIKNHTDNRICTEIGMKELMIEKEKHRSKPTTSQRTKRSRRFATQSGESENEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGU4</accession>
    <name>A0A8H5FGU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclohexanone monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000229">
        <property type="protein sequence ID" value="KAF5336266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGU4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5336266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="64754" checksum="CB2E7E185876343D" modified="2022-01-19" version="1">MAPPSNTTTNDELDALVVGAGFSGLYHLYQLRKLGFSVKIFESGSGMGGVWHWNCYPGARVDSEVPLYEFSIEELWKDWKWTERFPDRNELCSYFDYVGKKLDLTKDISFNTRVTAARFDSSTERWTVTTELGTIVRPRFLILSVGFAAKIHIPDFPGLDRFQGIWHHTANWPQQEVDVKGKRVGVIGTGSTGVQVVTDIGPKVKHLTVFQRSPAIALPMNQTKVDEERHQKMRELSPLIYSRRKQTLSGHNIQPIPQDTFSVSREERYLTWEDLWSRGGLNFAVGNYRDVMVNQEANDELYAFWRDKTRARLTNPTMQEKLAPTVSPYPFGAKRPVMEGSYYDVFNQPNVELVDATEAHIQEITPKGILTSDGIEHEFDILVIACGFDSVTGGITQIDIRGLDGTSIKEKWAGGVYTNLGMTTANFPNMFFLYGPQAPTALSNGPTCIEIQADWINRCIQYMTDNKLTRIEATREAEQEWRDLNMSVAGGTLLGKAKSWYNGSNIPGKPVEPLNFAGGIPYYKSALQEREDQGYKGFILLGSPDGKDFAGSCETEYKTEIANGHAKGVNAEPIVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FIG1</accession>
    <name>A0A8H5FIG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FIG1"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="61" mass="6959" checksum="83F32455664FD4D2" modified="2022-01-19" version="1">MKRRDQTVMSFTPDLLRKIQFDLSRQTQAERRTSVLQDVTLVPNVIVVLTIRSSSPMRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJG8</accession>
    <name>A0A8H5FJG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000188">
        <property type="protein sequence ID" value="KAF5339074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJG8"/>
    <dbReference type="OrthoDB" id="2634326at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="693" mass="78137" checksum="94F5A7A6E09CB110" modified="2022-01-19" version="1">MDRTLTRGDHLVDHSGPRHQDPVTILKPGKSGEVVRYYEGIAGYVLPGSGRVVTTPNMNIVYAPWADCCSTRMRKDFFFGKDDPLCFPQPFHHSIAHLAVIPVPSTLPDSPLALAWYRPTLNDFASHDPIKPWDGLGTFKRDLLIRLQTFSDSLMTGLKGSTSQIAQDYHISNGRLQLRELVDQLDLPACREECCLRLARLQRCFLELYARWKWLTVYSLRVQREDPFPVDRTLTGAFTDDLSIASKLFHCGIPLWLVRDIEQTSGVRVDRISKAIDESANRLIPIRDSDEFFDVSDAVPPHPIIWSGLPGKAERYLAMSHYTRTLFSYSLLGTFEPSSSSSSLANRTPVTQQEAWVDALGSGEVIPEQSKDRKGSKKPYARSKPSPSSSLQRNKFIPIEHAFNPPAVPAWTTALVELKAFGLNPPPSKLKNFVPDPEILIGSSDDSTKSRLIRSWIKVREIFLYRLSSSGSTPLKLSNSEWRLILELSGGLTFQTGTKTANQLEAAQRLLKAYVDDSRHGIQLRVADLPSAVASWRGVEVEAGELVPVDMAREVLWELYEISFRMEFLALDQHMLSQLTEEERSNRRLQLNVCWAGLPFRAEAEHWDKGLTARSIKSRLPYIQAFFRTLSGWPGQQPAVLRHSFPTPSTNGSITEEGFLGTVANIELILARYYVRSFYNVFSRPPIVPHHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJM1</accession>
    <name>A0A8H5FJM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJM1"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000008">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="125" mass="14093" checksum="06D6DC35D7B96EB1" modified="2022-01-19" version="1">MVYIQSWQEYQDAAEELYKNSPNTTRYCIKWKSSEGKLVLKITDNVSCIKFKTYSSIFLNRFEALNLSLMEKMQNRRIIEAPKSEATKVEPSSEASAVPPALVTPTPSASTSGGVTKKKKPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNG2</accession>
    <name>A0A8H5FNG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000143">
        <property type="protein sequence ID" value="KAF5343289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNG2"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="218" mass="24286" checksum="4544971E1BC6D8DA" modified="2022-01-19" version="1">MKKMLSTPSGSALKEYMWGVSFEGRGGKIGKILIHWRIHLPKLLLLNTVAFVPQSISTNMLSDPTLYSGSPKIPSSYFIYRTRTLSPSNCPYCSIVLNDHPTCLHPTQRIMVDTREIVSFYPWGHLVPQIFTNQLRTEEGGEGLDIRPSIAVTCAHIKLSKLDETVRRWEIDVDGKIVMKTRLVKREDGGMDGGVDPGMEVAVTKVVVEPISYLTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNZ1</accession>
    <name>A0A8H5FNZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNZ1"/>
    <dbReference type="OrthoDB" id="162969at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="41014" checksum="A7A14514044F3B7A" modified="2022-01-19" version="1">MHGKKQDKTCITLHFIVNATGTESYPIMFIGHYAKPRCFGKIGPNKRGFYYHNNKTAWQTSELYEECIKALDLHFGREGRKVILWSDNFSGHDITYEPKNICLERFEPNLTLFIQPLDQGIIRAFKAYFRKLFCLRAVECDEAGERDVYAIDMLEALRMATKAWSMITEKTIVNCWRKAGIIATRTEQDMCQRDEELELRAWRILRDFARKKAEGWLQELYEGDFRVEYDVSKWEVMINRITELEPDDEVSEQHILEIINTHLVPIPTSSNSQPNPPSHNTDLDEVEADLLKIVEDLKTQKRIFGQLPTINELVDPLEEKGDGNDEFRFGDNAEEQIVERVKYKEAVRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPV5</accession>
    <name>A0A8H5FPV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000119">
        <property type="protein sequence ID" value="KAF5344741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPV5"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68624" checksum="1A991D8438A89122" modified="2022-01-19" version="1">MASNLSEDNANADASSPSQSQNILKLKDDGNELYVAKDYVSAIAKYTEAIELDGSNALVWANRAACRLAVKEYEEALADAMKATDLDPTYSKAWARRAAAHEALRQYSESKVMWEKALEALPSGPDLSQTDKRLKTQYEANIKAMNVAIGREGKAATVTSAEFSQLAPGAVEVQKDSGNLPWEVARSMLEDLSTRNDPNSSEWTAGMEGLKELKTQFQENGQQVSVGKLGVIDMFTSAIMRDTRIFRISEEDFLIKFFDQLQLERKQWKAWPGNTDLEVIKREALERLEKEGRETVRLALNIAVRWVSFLPSCDGANILKRPSSSCVCSEWIMSGFLSTRIEPDFEVAIDHLQRALDVINWGREVWKDVPRKERGVIFTTTFKRGIWNMLLSATLQAHVSISTKNASEPKDDLEAKSKERELLENINKHASGILKDLEEDSLDPKEFDGPLDPGFRWSFFDNIRGNAFACTGYYHVQLAEANKADQDKFYLHMLTASKCYYKAAGGFSEDDYNHTWYLSCAFEYMVPIGPPTGLVLEVLEKIRVSEPKSKSLWFREPGMAREDQAKAYERLKVIEDRVKELIRDGKMKTDEKFDFGKVQEGLGRLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ93</accession>
    <name>A0A8H5FQ93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ93"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="109" mass="12309" checksum="9C85083E04B8FDC6" modified="2022-01-19" version="1">MNGNVPEVSSLIPTTTTFSFIITSFFTITSMSKNQRKCLDIIVPSPDHLLYTHPNPSFDHSPRQPVLRVVRLVWLGLQSGENPFRERDFFGEGGEGQRVESWTEEVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1L8</accession>
    <name>A0A8H5G1L8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1L8"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="14440" checksum="ACE8381CF778B0EB" modified="2022-01-19" version="1">MSTSVTSIDTRAVAPPSVDPLQKRSRPRRLINTCTIELEEFPSDDSVPAYAILSHCWEEGQEISYEEMVNCRSSIAWPFIRSKSGYKKIVAACKASTWSQTRLHLDRYLLHQQGRPRPTIAGYQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1M6</accession>
    <name>A0A8H5G1M6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1M6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="169" mass="19071" checksum="3699F2EA22E48DC6" modified="2022-01-19" version="1">MEAESHQPLTPDSAIMSTPVKSTDINLQTLVLDFLCNALIADPRWEDIISVATTSVATPSLLDPLQKRLLRLINTRAIELEESPSNHSMPSHAILSQEGQEISYQEMINRRSGLATWLSIHFRRVYKKIITVCRQTRQGKHPYIQIESHQLLTPIGVCRHNSSCDTFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G331</accession>
    <name>A0A8H5G331_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G331"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5357400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="131" mass="15276" checksum="481C5B14E59A5E1F" modified="2022-01-19" version="1">MRMLEQEQENDDSTEVTWEDQQRINTFSKLNTRIKSIETQLEVLKQEKEALDDLSMELELADEDEPVLYKVGEAFLHLPLPRALKRLEKDQAKIESRFSSLTVSAEEIEREMKLLKVTLYGKFGSSINLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G399</accession>
    <name>A0A8H5G399_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G399"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5357463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="138" mass="15353" checksum="48E921F157ADE7E6" modified="2022-01-19" version="1">MLLGGRLRSSYIRHVRDNATGGDDYLAVIKLWCHGFRYRVVDVEAALWDSNVDVEECSVFPILHSLVTTTPGGLEIFFFDFLLLPVDPKTPFEELEGFFLGGYWRGALCCCKFGGIATSDPAKVKLVPRGIPDRGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G610</accession>
    <name>A0A8H5G610_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">D9758_004816</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G610"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF5358994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="385" mass="41764" checksum="A148466A3961E2BF" modified="2022-01-19" version="1">MPGRSRRRWILIGSIVGLVALIAIGVGVGVGVTRNNDNDDNDNNRAASASSSGNSSTGSTSDGAPAQTDPNDPSTFVRDSRLHQSFWGMAYTPEGSQLPNCSNSLENVIKDIQLMSQLTSRIRLYGADCNQSALVLEAIKQTKTNVSVYLGIFNVPDDHTAYTRQRDLVKEALQTYGTDHVLGVTVGNEFMLNYLNDKGSDDPNSSIGDEGAQLILADIADTRSMLSEIGVSLPVGNSDAGFYFNNKVLAGIDYGMSNVHAWFANTTIQAAAGWVNDFFQETNVQPTAALPNHPKMYIAETGWPTESSDEGNKNNGASDASEANLQIFLDTFVCQANTNGTGYFFFEYFDEPWKDAQFGGVEGWWGLFDSNRTLKNIQIPDCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G649</accession>
    <name>A0A8H5G649_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_004865</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G649"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034979016" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="220"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5358921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="610" mass="66069" checksum="4500A27257A06863" modified="2022-01-19" version="1">MRFTQSSLPFLTLLSVVFAVPSKDPAPEVKESINPPRGWTLRSAAPSHHTIELRIGLPQPSFPVLEKHLYEVSDPFHERYGQHLTKAEVEALAAPHQESIDLVSEWLATHSIGESDIRRSPARDWVTIKIPITLAEKMLDTTYHVWTHDASGDSILRTTSYSLPKHLHPHIDVIQPTTMFARFKGYRSTIHDIDRSPSLPAYTGDSTNSGAVIDPSCNTTITISCLQQLYSVPSDFTPSAHVGNSIGVTGYLEKFANRQDLQSFYADQRPEAVGSTFNFVSVKGGLNDQNLSNAGGEADLDVQFAFGLSFPVNSTFFSTAGHPPFIPDINTPMDTNEPYADWLDFILAQEKPPLAISTSYGDDEQFLTVGVPWFQKTVPESFARRVCAGFAQLGARGVSLVFSSGDGGVGDGDDNPATQTCLTNDGKNQTKFIPEFPASCPFVTAVGGTESIEPEIGVFFSGGGFSNFFARPSYQDKAVGKFLSALPKGTFEGLFNPNGRAIPDVAAQGVGFRIFLRGQIVSMAGTSASSPTFTGIVALLNDVRLRAGQPPLGFLNPLLYTIPEGFNDITIGNNPGCGTKGFNATTGWDAVTGLGTPNFSKLRDLVIRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7S0</accession>
    <name>A0A8H5G7S0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7S0"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5359938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32980" checksum="469F6ECAD2DE8A35" modified="2022-01-19" version="1">MSTNTASATVSQTDPMSTKEKAVVSRKFGPETGGDVVFRSSDNVSFHVHQKHLEVYAEGFPLAKHTTPSQNEIIPLSEKSSTLEHLFQFMLPQRPPELDGLDFEQLMALANASEKYVVYSAQSTCALYMRDFLTSHPEQILKYAATYHHNSVIYTLAPQLVMKPLTELANLLPHDVFVPWSIYRSNFHGLLSALGDACAISSTHPQQHKFQEVRWLRKIQQVKDEIKKDPTKLSQFRTLIYQADLAGEKVCECHCCNPFKEWVTKVCGDIGKMEDIKIIARKYLAEKYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7X6</accession>
    <name>A0A8H5G7X6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7X6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5359936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="350" mass="38683" checksum="68C8D6B0773BC848" modified="2022-01-19" version="1">MQCSPNITINSDPFNRLTSSIWQVIFMREHVKRWKSVEVVMDSERVEVFSVRSPSQGCSVQREREMEMPFLECLKLKFVYFGGYNFYLDSHHPSYDDNHNHNSNDLDHDLNLFANAPRLRHVSIIDNAGCMLGNPATQADGIFIIAAAAATTTTTTTTTTISTTSTTTIGNNGNATNGYNGDNHTEAQAQTRPRGFTFILPRNQLEKLECGGRFIPQPKPKPVPNLMFPVPPYTPTPGLGLGPSVAAAVAEAEGQGIGQGQGDMGVDVDMIWDDYGWYDGYDGYDYVYVTHAYPAFANLTELSYTLDIPSMFFSAPAPTHTHPHSPSPSPIIVISTLMPTQIQPSHLYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8E9</accession>
    <name>A0A8H5G8E9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G8E9"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="477" mass="52539" checksum="6021778507BC25FE" modified="2022-01-19" version="1">MAYRMHTELELRLLAFIYHHLGSSEIYPKPYTYISCPPSTSSRFLCFPTMLSLLPGSCCDVCAEEYGPHTLPHSIACGHVLCSRCCDTIIEKTSPRHSPACPFCREQFTSDNVRLIRTDFSSSGWNTPRRLPTPLPLADSVADLWSRREEKILLGSEGRPRDEARRLEDKVARIASKKCSVEEVSTLHQELEAWLKSPVKNGDQSSSSLHLSAALLRAILMNHVVHTEASKTAKNLEATLKGKIDDLEIKNGKLEAELRHKLIFVDVDRQDFNQKAQECQSLRTELTRLKVVATTLGTPSPSSTPDTAARSRAMSPPPPSSTPAPPSLTSPSRFGSLHMRSASMHASSRPSTPATSPTHSSVRSHTPSVPLRSQTPAIPSRLATATPSPMNLRAQTPGPPIPPKPRRLSTPSPPQMARSVSEEKQQAYQIHERWIPPGDHPVKPATPAPPMQRSTSRASDAAYPKLRGMRSPSPGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAK9</accession>
    <name>A0A8H5GAK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAK9"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="78" mass="9171" checksum="D9A18551027A3F75" modified="2022-01-19" version="1">MNVGLRDALRRVRHPDKMRAIWADQICINQDDLFERKIQVSYMDKVYNRAKRVLVWVGEEDRFTAAAFSMFVGLHNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB15</accession>
    <name>A0A8H5GB15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000039">
        <property type="protein sequence ID" value="KAF5361604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB15"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5361604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="31076" checksum="93ED1DE16DCEAE45" modified="2022-01-19" version="1">MPTGYRIDYAPSNRAKCKGPKPCSGTIINKDDLRHGTMIDFQGKPSFQYRHWGCVTKKIIENMKAQFETADEVDGFEELKPEDQARVRKAWEDGHVADEDIPDSARKPEGEDAGEEEDEEKPKKKRAPAKKKAAAEDGEEKPKKARAPRKKKEEANDDGEKPKKKAPAKKRVTKKKKDEESSEGEDFTKELEAVDIGSDEEAEAKETPPPKKKAPARKTKAKKDEEEEGDDDDAEVGKKRKKPASKSASKPASKKAKPSSSKAKKSRAAASDDDANEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH37</accession>
    <name>A0A8H5GH37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH37"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="52" mass="5724" checksum="818F29348E8C7178" modified="2022-01-19" version="1">MDAAHINLHKVIGAVIIGTWVNLMLFVLVIDRSQSLGLLSTWTLEANRSYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHH8</accession>
    <name>A0A8H5GHH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHH8"/>
    <dbReference type="OrthoDB" id="2548253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="734" mass="84119" checksum="D68CD9C51676BFAC" modified="2022-01-19" version="1">MSDRQTRPRLPVHSTETPHRTSRPLRKYCLWFSGFIVLTVSAYYLPSVYTFMHTVYRGNAYPQQFLYQNQTLSEVSNRSLVIQPLIDNDQTFDVAVSVWIRGTEAEELKWRASQEGSDEDYQKLRVMSWHDGEDILNDRKQLYYPLYSDIAFRGLRLSDKNKYASINFTLPTEKFREHRLPTNTLIATFVLIPTSPSLMDSVVNYSSYIPEEVWSKAPAVRTWPFPMGSEYTGEKTLADLALESFSLQTSLIQYHHIPFRCPDGNETATADNVLDELSSFKDGIINDHPHVTTWSQLRVVDETHIMNLQAYNELHEDLKTRSCGRGFRDLKPLRRYCKSPYLETGNLETRLELEMKDSQGTHTEWAYAPYMTVFDSASGPMDLVPVPVHRENCTGKTIVEQKFNFTESDTMDITWHITFSGRSPTKLQIGNTATPHTVNHRQSDYEKIVAQDKAELSNGFYGMRKPGSHPRRRMVLSFLSASLTVVIAILESIYWFFRSSTIHISIPGTVLLGLEEILGVVQVLVSTYAPLSGPFPSAPYIMESAVFSSPSLPLAYWMLRTVLRIELVWKGGLPTFRRRSASHSERASERLDATMSWTARISILSTLFLCFYFLRDYMDLLPAVNPAPDSKESRINYLLAACVHSFWFTGYLSQIILNYKSGHYAGSYKSAMYLMWFKKALFFLDYVPAVVGRYQTKPALWLPSIISWFVQSVLVYQSITLPAVSTVEGHEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHR6</accession>
    <name>A0A8H5GHR6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHR6"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="302"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="79710" checksum="2EFE9A851D95F51A" modified="2022-01-19" version="1">MLVYTRRTTIYTTTVESYCVPDFDSPSIFARILDKDKGGHFSITPTVPFRTKQNYLPSSNVLQTKFMNEKGVVSITDFLPRQARHFYTSTKPMLHWLIRRVEVIRGSMPVRMECAPAFNYARDSHQTSIIPDDSVPPTEYLGHAANDHMKAFFESKGLNLDLRYTIESVLENVDAPNPKLSLLDLSSKGHLGPGVCSEMTLTEGQCITWVLRIAPGTAITPDDVRTPVTGVSTPDPNRELGDDYGKLSSGAKASIPGQKILGKVRPGNDPFLTKELVHTLLFSTNKYWNDWIRNSTYAGSWKEAVNRSALALKLLIYEPTGAVVASPTFSLPEYIGGGRNWDYRASWIRDSSFTLYALIRLGFTHEANAYMEFIFERLRDKNPDGSLQIMYTIHGGKDLEEIELTHLDGHKGSKPVRIGNGAADHLQLDIYGELMDCIYLGQKFGKPLAYDDWILVRELVDYVVQHLKEPDLSIWSVLKLPHSTKASYDYREVRNKKRHFTYSKIMLWVAIDRGLRLADKRSLPCPHRNQWLAARDELYEEIMTKAWNKELQAFGQSYEENDVMDSAVLIMPLVFFIQASDPRFMNTLKRILRTPERGGLTANNLVFRYDVNKASDGVGGEEGTFCLCTLWCVEALTRAGVFDKTLVPRAVSMFEDFLMYLNHVGLCTEEISDAGEGLGNAVQGFTHVTLISAAYNLSKTLQGGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHZ1</accession>
    <name>A0A8H5GHZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHZ1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="38455" checksum="3DCB8634024483E6" modified="2022-01-19" version="1">MTSSSSSGRSGTQSHLRNRSSQSQSHSFKPRLDRAHPRFQNSPRLPPRPSYPSSDVLLGLETHFDTDFDDFDHEARKFKSFKFPRGDFSPISPVSPGPITPTTSTPVSLRHHRKQTLHPKNCLPSPVIAPGTDAEQDGYSYGYDSLRLGWRQGLEEKDHHDSDFYSPSVVNSEMCKCTCDVAPPPYQSQSSSDCGHYSLSPSYTSAPSYTSASSHSSCINCPASSLYASCDEKVLDLTPMDSSPVAFNNCSSFSFSSFWSGPTQILPTHHFHSTESQSPHFLGLNQSYGFGFNRYLPYLGFRSTYLSNCLRRLLGRKTIRIVARGSWIALVLFMVLALWFIAMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ21</accession>
    <name>A0A8H5GJ21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ21"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62146" checksum="3C616F6FA84D1AC8" modified="2022-01-19" version="1">MLNTPYLLAIPVLLVIYYFCGYLLRRSRQKLSYPPGPRGLPIIGSFFDVLTPRTGLDAQWAIYRDMGNMYHSDLLHINILGNHTVVVNSAKAAEELLERRSGIYSSRPPMHMAHESGLGYDFGTMPYTSWWRLHRGTFHQYFRSDAIAAHHPFIHQATSQLLRSLSCIQSTTMVTQYDDLRAIVRQHAASIFLYTTYGITEQEDMDAFVKLVNNATESFPTIVHGTFLVDYFPLLRYVPAWFPGAHFKQKATRWAQFNSELLNKPWKQLKASISSGTAISCFGTKSLQKFDSTFNTDATGDTSDLGMSKTDSDTNMEEVIRNCAAVAYTAGSDTSVSLILISVLVLSHHPEIQAKAQEELDRVLGSTPNATQLPDFSNRGSLPYVEAILKELMRMYPSVPLGLPHCSVADDVYEGYFIPKGTTVVGNAWTILHDENIYPDPHTFSPDRFLRTEPQRGALSVKHSVNPDPELYAFGFGRRICPGRHLALDTSWLVLACILATCNITRISNDKPEIDPIADFADGLTAHPKPFKCSVTPRSAGAFELMKRGYDVGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ67</accession>
    <name>A0A8H5GJ67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ67"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="99"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="253"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="417" mass="46076" checksum="501A3337FEFD0AA0" modified="2022-01-19" version="1">MKRGIRERTRVTRTDLYLHGRKREYDHVVTWPRKIDSTAASRQLILACFAMSTDHQQQAIQLLKLGIEACSIALQSVAECPHEDPPPSSFSVIRTDFMSLLAFIYATATKLAISLKPSSPTYSASITPLKDMTKHVAALSHCVNMFNVKEHGKTFTQEAVSLFRDVATSVQSLLQLFLDVEQSDDRNKWKEEYLVRTAAVHDITENARSSHGLSKDNSSAVHKIWSRDLGSLEDGVREVAEMTENAESGDTEEDDGWGELGLESSKPLDKEELARISKIHTVLRLATLLHKRIASDLLRSPPHGVSSTTLDKLASYSPTLLSASDEVIASLFSPQDVSSIQKELDSFTHIIQDIKTVVGSFLDDASSEAPEEALKELSLNGSTGKSSSPRKWFDGCFEQISKSLDIAAVTLNDNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJF7</accession>
    <name>A0A8H5GJF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJF7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="122" mass="13514" checksum="2DB900C96F369BCA" modified="2022-01-19" version="1">MVGLPDKFEIRGDFDSSSSGLSASTTGSTATICTPTFFTLRSSTPTSTAVPQATSSRFPHLFDLSIDGTVFKPSNPLAEQQDKLERRGFGTVWIERGMDYRGYRVWELAIEVLRPSTLAWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJR2</accession>
    <name>A0A8H5GJR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJR2"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="806"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="926" mass="101624" checksum="5314AFF42931C9B7" modified="2022-01-19" version="1">MTSYPTQDTYARLLLHHKLGYPLWLPEPNQEDRLRTRIVREEDINNPRDGIPWDIYRNSTPPEYSAMGIVPNLYAEGIRIGDVGLATKHGFVTLFNIFLPENDPVNTRVPYGVPPGFATLKFHRDQLWTADCHTQTPIYSKHTREIKLAVDGTALPPGAIVGPGVGVEVHFLRSRGAALLLPEGAYRVDYDGLPAIRDYVVQNVESWYQYFERLGTNIDVYNGDIYIITGYDKTHSYENMSFQHHSGEASISLRVASPILANGDLGKLAMSFSSSTMHTPSTGASRPEHRLKNLSVFIRGYKIMFNHTSRLFSKKRPIQLRDVTDDKSKNLVFRGDRLRRDPSSSQGSSGSHPALSSGGMQEEETQYPSDDSSDSESRGSSILDSEPDNIPNEAYHPSNIINSCMLETHPDASAALTHDKDWFTLVEETDEEFPSENILKTRLKERYQTSLQQGLVYLVGPSTTRNPSEQLAEIKLAAVHAIDSGEEEKDDDKDEDISHFDAQKAQDIPVPQLSSASVSADRRSLKEPGADIALPTPGSVMGSAFSLSPAESSESEDARKRSLRTTKGSLRVPIPAPSAIPGMFTPPGSPSPSSPASPVESLYGLRERTAPNIPMSHFDDTLTVQEGKNAWPISIDEQNIETSSIPIPHLPWTQYMVPSQQSNGGMPSPDNTAGGSGPSANNRKLGLYKTELCRSWEEKGSCRYGSKCQFAHGEEELREVAHHPKYKTEICRTFWVSGSCPYGKRCCFIHTELPSSAAAVGGQPPADSVPPPSSRADGHALSKSTNSDPNDASGLLSKFFARISAKRTQDQNTETSSTPVETLPPGFPFGSRPPTGTLRVNTSVLDGSEMKQQYKSAYPTFANNSVLLPAQEQIAARSPAPVTAGPDFGRHNNSRLEIVGYNQRMNKAGTPSGRHAPSGSEDLRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKC8</accession>
    <name>A0A8H5GKC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKC8"/>
    <dbReference type="OrthoDB" id="2649667at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="215" mass="24679" checksum="1B74C394599FF0EA" modified="2022-01-19" version="1">MHAEHGGMDGVLLAYRPYWYGKSYFDCKSRYSLNVQIVLLPNWHIIDFSYGHVGSTHDATAWEETRLFKEYESLLQDEWIWADSAYPIQIWVVTPYKKPDCYKPENEEFNEAVRIDNAQAHHISTFWIAACIGIHSHAMQSEAKEKDEEGGYDFFERDPFLAEGHSDGSDVEEVVTGTFTAPRPQANGRVNPHLAATQEFCEKLKADLFASRHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL61</accession>
    <name>A0A8H5GL61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL61"/>
    <dbReference type="OrthoDB" id="2870744at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61469" checksum="5805B289C717D3B4" modified="2022-01-19" version="1">MDSVIGKTSRSLSSSLRLNLSISKKKRLDLSTASINKALPKPPTLEASDAVPAGDCSPREVPDDVIYEIVKWLPLQDVLHCALMRRSLYELCRPFLYGSVNLSYSEACRSGLEYFSRRRDLARFIKSLTLRPNVGAGWSNKAEKVIDEEWIISVVEELALDGSLASLRAFYWFGRLNPPDSLWLVLRNHCPDLRYIGLRVTISVGLTELLHPQTLHFRNLKGFHLTTQILDRGFVLIPRNRSLPPGLWTMLLENSPNLEELTLDGACLSDELWQLDPVLHGRWPSLRKFAIGHISAFDSASSSLPQKVADFLDAHYYSLEDMSLIGNATYTELSIPKFLSMPNMHTWKGRLAHLTHAGPECRLRNLYLTDWFSPSAKIGDLLKNLPHLELLSVFVNFVDTVPEWDFYEQLLTGCPQLKHLEISSTSHLSLINFSAALRLVPNLQTFTVTRCRKFSNMGLTGGSLTGGAALIASQNLNLSQITIRDVSNWEHHDQLSGVYKTKRIGTFYIVGGGPGFPNQLIGREFGVNPLGQRFSRSLVHALVLPTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLA9</accession>
    <name>A0A8H5GLA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_003974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLA9"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="398"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="719"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5367093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="841" mass="92197" checksum="38EAAA11FAB8726C" modified="2022-01-19" version="1">MIGWHMDCLDPPIEQAPSGNWFCPNCVAFSPDMAFFAHGLPPFMNPEGEERETPRSARRGRGRGRGRGRGRGISSRRSRSAVVPDDEEGEEEEEEEEATPRRARANNKRSRKAGGVGVVPKLVSSSSSSESESSSSSDSGSDTQIVSVVSASAKRSRSRKKPKPKRPRTSTTTTRRIKVRLKLSNGAAYGDQVSDDEDSDGYDLRSSNPANANNKGLFDDILGEQDRDTSKTSIQGLDKVRFERSRVVAEEKLNPPQGQSAESQGEDEPLVNGKSKGKGKSTAKAKGAVKGRAGPGPDLESTPLPPSTAGAGPSRSRPLRSSGIFHAPSTPNLKLRLPSSSSSTSPGPDSVAGPFTPGPVPTITPKSSRFSKVSTPKSKFSKTTPLPLNPITNGNTNTNPLRIKSIRFGPYEIATWYDAPFPEEYANIPDGKLWICEFCLKYMKSRFGAGRHRMKCKARHPPGDEIYRDGSISIFEVDGRRNKIYCQNLCLLSKLYLDHKSLFYDVEPFLFYVLTEIDDTGARFIGKKECEGLEFELYYDVAYEAEDGVGRLALFFSFGLSACLVLTRPVFFGGVAFELEPGRGHGHHGSDQYKISKLEKSYLLSKKEKRTGSPEKPLSALGALGYKNYWTLALMRYFDTAPEKPRLEDISLSTSMTLEDIYTTLLQLTHQQHPPIISISIPETTPPPTSIPFKLTPGQSIKFPKGRKIGKIGFARRGSGYVSRSNSQSQNGTNGVGSPAGYGHEGWTEDPHVNGNGAGAGASHMHINGHTHDHGHAQGTNPPPFVPPREYEIHWDREKVREYLDKWESKGYVKLKSEKLKWSPFLLTLSRGSLGLGSGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMI8</accession>
    <name>A0A8H5GMI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMI8"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
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            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5367499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="34957" checksum="B4CD9B378A2649F8" modified="2022-01-19" version="1">MTTEQPKPPSTTEQPATYAGPPPPHFIGGAIPPLPPGYPPFFTYPPPAEGQQPDSNGSTAPPYPLMYPPGMVYAFPQAPPAAPPAPPTTPRPKRKQVKMACTNCAAASKRCDENRPCNRCQKYGTADSCMDGQRKERKKGIKRGPYKRKNKPQTVESAYGVIPPPEVGEWPQGVPPPNAAGAPPIYAVAQFPPPEGYYPVFYPPPTAYPPPPDGQPNADGSQNSGQPPPPIMPFYIPGFPPFPYPPPPGTVFQFPPPGIVAHPPTASQPATGAAESEQEQQAEEKDEEATCVNPADLSDAAATDSHSKAHDGDANKTDEDENVEDGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMV3</accession>
    <name>A0A8H5GMV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMV3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="35364" checksum="B30B900F83A69C8A" modified="2022-01-19" version="1">MAFDSNASDAQGTLLSDEAIARMMRPYITTMFSEFNSKWQTRMDEELRKQREEFDALLRDTRWQEFLQACTTRSQVVEEAVHRAERAEASVRKLEKELVIVKERAAKVVIQATAQSFGKSAVLKALDEGDEEQRDSDGEDEDATKVHSSVDTKVHPYHRKTLTSDSKLSSSRLAKSINRSQSCPRPMISRRRPSSAPTPTASLSRCNPQAQRPLSESYPHPHRGDSSSTDNTASTSASDLPTPRPGNTDHGGPLLGGFAFPSHRLSLSQSTNDTTSTFDSSAPLHSHVAESEAALKDVLRSLSKYKRPSSITSISSAGVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN49</accession>
    <name>A0A8H5GN49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN49"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
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            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
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            <begin position="332"/>
            <end position="342"/>
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    </feature>
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            <begin position="358"/>
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    </feature>
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            <begin position="380"/>
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        <location>
            <begin position="429"/>
            <end position="440"/>
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    </feature>
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            <begin position="465"/>
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        </location>
    </feature>
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        <location>
            <begin position="475"/>
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    </feature>
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        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
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            <begin position="527"/>
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        </location>
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            <begin position="602"/>
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        <location>
            <begin position="659"/>
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    </feature>
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        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
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        <location>
            <begin position="791"/>
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        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
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        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAF5368071.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="880" mass="93888" checksum="D789E73840C135FD" modified="2022-01-19" version="1">MVSTPIDTDSFQVTLRSHKSVSTAKSKSTTTSRSKDPEDDRMDVDDEADEEQVDLDDDDATPSTPSSPKTSSTNPAHAVKRGQSPPLPLPLPTPPRSLRTRSTTSIHSTTKKAKNKIRFNANAKPVPVPVPIPTPPKTPARARTRTQSQSQSQTQQKPQSQQQPPLSNNQRLPRNRKPSPSPVPLQLTTDFADLLDKAMKEDYLEMSTRTNDAADDDDGFGVDKLDGVVPDDEDDDDEGDKDDNRGDGDDTGNEAEDEEEEVDQLLRDDGDGDNDFIPGAGTRDEAKDKDKALPHSHPRTRTRSQHLSNAGANGGAGVGPGISTRVTHSHAHAATNTTTNVSLFPGNEDPYTDSDADSNSRPDENSHPDTNTNSDHDQDADADADTDTYEDAPTGSKRKRKRGSGTSPCLRPRPRPSYLELGLGSSSAESDEDEDEDADADTYGSSMSLNARGRGLGRGRGRGTGRTTTTTTTTRKGEGERERGTNPPPRTRRRVWLQLDRERERESGVEDELEDEQSVSGGQGDDANTNTNTNANTNANPNPNPNPNPNLDVDVDVAGVGLDAPMSSSSSLPLPTSASTPLSFPFPTSFNSDTGTLFDIPSLSSSSSSSLYGFHLPSQSQSQSQSQLPNPYSSQSQSQSQFQQQYTTFRSLLQMFGANSNSNSTSAPNSTSAPNSTFTPGSGFGSGSDSVPAATSTSRLSLSHANWLPPPPPPPPPLPPPPLPPPPPPPTTTTTTTTTTPSTTTSINLIPDSESFSIPPSLPLPLNSSLPLPSSSSSSSSFSWPMLTMPMSASTSTSTSTSTSTSNYLPPTLPPGPPTPTPNSNSNSLLPTLPHTRPPFSIPHTRPPFLFPIPVPPFLFPIPVPPFLHPVHPVPPVHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPV2</accession>
    <name>A0A8H5GPV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPV2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="35628" checksum="EC8299206BCAFD9A" modified="2022-01-19" version="1">MSSIVLKRTGQKMPVVGFGLWKVTKSSCADTVYNAIKTGYRLLDGAGDYGNEKEAGEGVHRAIKDGLVKREELFITSKLWNTFHAKEHVKQMAKMQLDLWGLDYFDLYLIHFPVSLQYVEPKDKYPPEWWGLDGGVHLQNTPMQETWTCMEQLVDEGLAKNIGISNCQGSLICDIMRYARIAPQVLQVEIHPYLTQEPLLNFCKTLGMAVTAYSSLGPQSYVELGMDRGVVNLLKHDLIAKVAQDKGKSPAQVLLRWATQQGLAVIPKSNNQHRLLENLECSAFDLSEQEMKQLSGLNIGLRMNDPAEIDPRMAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ23</accession>
    <name>A0A8H5GQ23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ23"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116914" checksum="800C7C18401F02DF" modified="2022-01-19" version="1">MSDPFPEHGTEQRRNPSRRETVMNLVEMLLRDEADEEGQGNGRPDFEDDKGIPSADEAHQNAGAEAFHKFERCVNNLDTELRNFSNATRQLGSSAAILSSAFHLRTRLAQVKFLYRENAANLFPRKISHAGLPNNSTSNPEKRRRKIPYMSVRHRAMPHVARPVVTVSDNLDLEDFPEQFEKLAVEVTTFVNRLNEFPEFTDEAVNASISSFEGDLKYWASCLKEYEGQFRYPAIQRYVQDLTAEITEHIENITDTISIFVEVGVPTIRFAQQHEAENLQNLSTVATFFSGVTATTLSLSVDNLDGPVSHVINLFWFISLVFSIAAAVNSLLGLTWKQAMYRSPGHRVPWWVLIWIKRSPLFFLVISAACFSAALCLFTYDSGQHRITSVMTTAMTSVTSFGLIAVSTWFALERWAWSRHRGKKWLGDVLDENKTKFIRKSGIEKMSQGFGWIKGRFRTAGDKLFGACLCFRPRNDVDKVDQTLPSLPVTNPSQREETFSRMSSPMPSPPMPPSSILFSPMPTHILPSTIPFSPMPSSPMPSSPVLPPSRPPAPLSPIFLNFSPRNRQAELRSASPFTISSVHSTSTTNGGPVSPVTPDASKQGRQLWQNAIRTVKTKSQVTSKLAVIDARNRLGSRRQRTGSSVVPVSDGQRPPEEVKVVPSRVAALKPQLRSLEATQDLAAHQALVRHLQFSPDGKFLATSSWDRLSVIFRVGDPCVSHRVLAHAQGFVGQVAWSPDGKCLLTKLVRAIKVWTLDGVCSRTIDRQQSDSVEAITWLPGGEAFLSVEGSNVVKLDLQGKVLATYNFGNMKVYDVACSPDCVRLLGVGPMLLSPSGLRPSKSKVERRLVVYNMQTRQIENVTPVLDDVRHIKLARKKRNGVAALVSYENKAPPQLWKLEIVRDLKNEKQLIPRLTLRHTYMQQTPIDSAGPSYFGGKNDELVLCADKIGDIHIWDRESGALLHHIRGQTHYGDLTCMAWNTAAEESFMFATGSHDGAVRIWSKPSEFDCSSPESMIDNIQCSSPDAFENLELTTSLVEEQLESALFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR45</accession>
    <name>A0A8H5GR45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR45"/>
    <dbReference type="OrthoDB" id="3359674at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="458" mass="51768" checksum="25BD5309A5853CBE" modified="2022-01-19" version="1">MSAPISSLPAELLIETFTFCAALDHLAPLTLSLVCGFWRRVILSSPRVWQYILLDDERAPAALLAQAQLWIKQSAPLHFNVRLHLHSADNILSLLSPFLPVIHRWGELVISGDHEETVYLPDVISRLDTLNDLSVSVCDKEYADDMSSSAVSTFSPYSPLWPNRINMHVLLSKIPEHLHPLRFTSISITEHCLSTHPKASEILHFLRSCPCVQTFCLTGLIHQDNHSRDVLPIVSLPSLKTLQLRSTCMTRQILSSIITPKLSELYLCHLNVDFRLPGDYHEAGDSEDDAHDFSQSPSSDRATGMGLRNLITRCNPPIKTLEMDFSDMRTKDFIWVFDRLTELEDFLIVASDMSNTVIRLLRPFMPKGVGDEGEIDPCLSPAPTHQIRLPRLKTLELHNCHRLSGEMIVDTLISRVKYTDRYIPEETMKEIAIVECDGFTPQHGQVLLKEIGTRVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRA0</accession>
    <name>A0A8H5GRA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRA0"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="172"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="35864" checksum="8FF43260678BCD89" modified="2022-01-19" version="1">MNRRQGVTARPASSEEIDCWSHATTSLSALSGIYSSPATVETIGRVNRLISAWPPDDTLPAEGLDGVRTIYKKLASGLEQIQVSSGQETKAIEDALEHLGVLIALREAPEHVATDKRINKRPRAPSPSGTPVPVSQPSNRNMSITLPARASVGPSPVPFSREPKARRAALEKQLPLQEGRKVAFHPPPNKANGATESDDNWILAVVTKCINADKNRYEVHDPEPQESGDPGGKYNTTLRSIIPLPDLSAPVGSPSSLAAYREFTAGSTVMALYPDTSCFYRAEVIATPREMQPQGRAAPSYVPTYKVKFEDDDNQEHLVSAQWVVEWPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRA5</accession>
    <name>A0A8H5GRA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRA5"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="38720" checksum="626FC1DF4E06653F" modified="2022-01-19" version="1">MSTDSTKPTANPFESNPESNQAQPHDAANPPTNVTTPPVAIPSVTTPSNEHPQSASSTPEITPQTTRPESTPQTTQERDAPIDPRVSALRAMFPDFDDAVLLSVLESVGGNQDRAIDVLLGMNDPDYHSELPPQEPVLSQTELDERFARQLFLEDEQRQQQRQAAWEAQQRSTQSQPPNTGERDTMTEIGEQFNKIAESGKKTFGSIYSRVKAKIQELDQPRPPPSSSTGSGTAAQSQTQYQQFQGHSQQQQQPAYYDPNPQSPDVATAQGYDVIQSPDVESSAKNGGTTSSGTSPPPATSTGSDIDSGKLGLLPKRPVSLLRAENTPGQTQPQPATRRDSDELEYAENPFEEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS94</accession>
    <name>A0A8H5GS94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS94"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="93" mass="10669" checksum="D1D8B11E31B08CF0" modified="2022-01-19" version="1">MLSDVTRHAIETEARLNKKPFIQALSSTLSPQRLASSCLEIHGKRLAFGLYAWFLGFVMEIWVDFQPHGRWPVQEPLLPKSDEGQLLKYDADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSD2</accession>
    <name>A0A8H5GSD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CipC protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSD2"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11472" checksum="4F093492310E4D24" modified="2022-01-19" version="1">MGWFSDDSDQAQAYNQVVDAPHKAELSHELIAGAASYEAAKAYEKHCEKNGQPASHAEAKELFAGFAGAFIDRMVETKGLDYVDKEKAKHQAHKQAEEQLASDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV31</accession>
    <name>A0A8H5GV31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV31"/>
    <dbReference type="OrthoDB" id="2657661at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="891" mass="100337" checksum="9A7C58DB1CDBA131" modified="2022-01-19" version="1">MTALQWLLKALRRLFYDKALRSSLRGIVLLWNFLKLQVKSARKSRRNGKVLKDGTVPGLEDDKLERAAQVAQKPPAEASVIVCASRVPDSVHLYPFSGPNASVSSQDIPTSSLNPEEGLPRPRTSSNSRISYPNISGHTRGSANASRVSIVGRGSRASSPASGTRISVYDPSTHASPVPSIRAPTPPPTVVIPNTQVPIPSHPSASHLSIDIPPANEDSFRITLRRPTGVLAGGEDGYDVALTTSPVQEGVTTAGNWPITEKRPMLKEIYENFFAMAPEIYFRYHEDGIVPKEIHEYKISPLTTCFQEPDPVGWKQCLHTEGARYFCYEEKKIYTDANILDERTRRHAMTLIQQFTDYCNEYQVQLSSSTNIVFDLFDQYIKGKTPENDYFKCRYYLVDHENRSVFWLDEFEATEFETWQSVKGVTELSHLRHEIEAQYWYHCHLFPDCIPLPTELVDELRGVLMHWIGDTLTSTTSTVPYPVGELQNMLSLASDFRKTTNPALCVSAYSRLMHIVARYRFTHFHGQTVVRLDRDRSVYLPPDFVPSQSWLMLSLSPWMFSTPDIYYNALNKIWIDGMMHEATWERFINGLKEQWQELILFGTVLLNANVAFLAIQSVDESTSLPQRSPAQIGSYLSVVATLGSIILGLFLARKHRVKPKESAADAANFLATWAMDENGDTNSTIGLETLAILYSVPYALLMWGVILFLVGFSAMCFESANVLVSSLIGCAWFVVTFFVTWCIFSLASWNQAGRKSFWEWVFGLVRHGMILLVLGVRMVLRRLSSGGCLSRGTSSPEEDEDGHSHSQNHSETNEKATVVQSPSDIHDHDQNRPYTPSHRRSPMEMETSALDSESQDDSDSRGRTSMRTLRRWKVSLFGQQRSSGDTGRTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWC4</accession>
    <name>A0A8H5GWC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWC4"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5372115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="504" mass="54077" checksum="B69BE8A97F2A9C74" modified="2022-01-19" version="1">MTSEETGLVYDPHVHDPEQNPNANLLNQSVNNYGTTTTSENTPAYHEQFSKERKLAIVGMISCCGLLPVFVSGSFLPTIPDIAEDLGTTGSVVSLTVSISVLAACIGALFGATYSGFYGRKPVYLVGLPLLTIGSIGVALSPSIEYLVIWRFLQTMGGAPGLSVGAGVIGDIYQLEERGTAMGIFFSATLLGPALAPFVGGLVTQFFSWRIMQLGLGFFGFLFFLLIVALTVFMQLFRFIICTMLPIGIEKRRQELQAQGKPESELKGFVWINPFKQLLLLRSPNLLGVAVAGTATLITDYVLLVPLAYTVGARYNIKSQAALGMCYIPIGVGNLITAPLAGHLSDRIVLKYRASRGGVWYPEDRLRGTFIGAGLLVPLSMVGVGIGATWGTGMVGLIFCLISLFMNGIGVDMVLSPIAAYIVDILHQRSAESIAANNAFRSILISLLIVPILPMVEAIGVFWTNVIAAVGSLVFGFAILWIVIRFGDRLRAWIDVGFSTAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX11</accession>
    <name>A0A8H5GX11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX11"/>
    <dbReference type="OrthoDB" id="3252971at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5372505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="578" mass="64743" checksum="39DD578AC25B2165" modified="2022-01-19" version="1">MAVPVEKRSVQKSQLPPSHLEFTLSPDRTQYIRRAHGRERSSACTSQYSDGNMHQYGLVILAFKEPISQPEIFTHIRAAWIKTRFEAPWIAYRCSSIKDDPEPNSFLLSYDIIGKNDKLTPNGLRSLEEWGDNSIMMRDEIYTFEEWEMWLKDHFWRPSEGHLGMESHVARGVDDMHWIVMCSAPHMTADARGIMSVFELYMKLVVKEVQDSKKPSYVPYERFPWGNEISKLTPAATTLLPDVGTEPVLKLDPSTMVLFDRQPFPSTAVPISANATSLFGDSLLNKITLSQTDTRAITLACSKAKCTMTVVMNSILLLADVEKTVGMLLAEAKKQNSPKMLALVEENWHKAEVWCIQINPIDMRGHVYPRYQALHGTSTSGGILNVMVPTYHSMAAIRKCLAIKDGKINRTWYNNPSAFWEDVIPDTKAFLKIVAQTPPSAFHESAAMSQKFAPLMGTVSADAMMGTKPLGMIPSSIGSMERLGLYRDFSPLYQKSKMGTDVEHPFVIPLMALGGRTHNTPAITVSAWDYNGSMVMNTQGSKRHQDAEGWNMFCYAAIEGFKQIVKGVTVTEGAKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY40</accession>
    <name>A0A8H5GY40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">D9758_001564</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY40"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="24">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="315"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF5373090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="646" mass="72419" checksum="E4597180B87EF2ED" modified="2022-01-19" version="1">MPSLSEKRIEELVKDVPDPSDFPENPQAPGLRDLDSSLRCPICAELFEAPVTLSCGHCFCSLCIRTSLGTKQECPSCRRTDVNEGHLRINPAMEEAVSAWQKSRPFILQLLKAEETRQNDALRPKKKRKLNDADPDTDIQCIPSSSRAGGSKQKMAKNSDGSATMSDTNEVMQSDPKPGDLVACPLCSKRVLFKNINSHIDKGCKDESQQRANTKTRWAGILGAQSNTTKTSKRKGKEPSSSDDEDLPLPKKSYGTLKDKAIKELLNEHGLPTTGDRNTLIARHQQWVILYNSNRDKSPQLRKNIDALRQELKQWESRQKGKNKVEISNTTAYQKQQKSEFDRLVAAAKPKKPGSSSSSSSPVPTQRRSVDPLPENDHDDTIILDSEEERTVKVTIANDGPVLFSPIFPALSMFPRHQPSPSIEVRVQQGEAGRQAAHQRSPKDNSIHSTSTYSTDKEGNYLLNPGSSSLRVVYNPTSNWDYCLDVVHTPIDLSLTLPHYRPRHQPSDARINMFVGTESSEPIKLKVCRNFARMKFYLEVHGSTADVVVWLPSDFRGRIQHSGRACFSSGFVNRIMQHVRFNDHRDDGFLEDCVVISTTGHITFRMWDVETCSPESTHKELLRRVFGCSKAAPETSGPNDWDFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYJ3</accession>
    <name>A0A8H5GYJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LigT-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYJ3"/>
    <dbReference type="OrthoDB" id="514292at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22222" checksum="3967F38B9E6418C6" modified="2022-01-19" version="1">MGVTLWIVPSEQDIKRLRRIMDLRPADSQVKSSASYPKFDPHITLAALPPDANIPLSKLKESIPTALPALEIQFNSVDTGSHFFRSVYIAVRLSPELSELHSKVHAALGVDPRTPSFPHISLCYITDEDAANGERERFRQTLVDSGKLRSNSDGTVSLNCAEAGEEDDWMTGFTSPEIWITTCDGPVEGWIVDDKVPLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZD6</accession>
    <name>A0A8H5GZD6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZD6"/>
    <dbReference type="OrthoDB" id="10343516at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034502025" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="80" mass="8163" checksum="C0C2C669C242587E" modified="2022-01-19" version="1">MRFTFFTLLAAVAVSSVSAQVWGVGDCGSPPAGSQCARYCIVCCDAFPDSPNCVTDATCMSLCSQNPTASPTTVASSMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H132</accession>
    <name>A0A8H5H132_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H132"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="356"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="653" mass="73130" checksum="3FE5884E39EF2065" modified="2022-01-19" version="1">MERIFCISGSAVTVFVEASELVDRSKIVRKLKNHGAKMCTRIQDARFIIVDPETFSGRLIVSEWGQVPDKIILAHSWVSKCVDAKRLLDEMDDWGGCAAKGNTTTVAERIEDPEQQNLPPSRLRVFKHREDSCTPQATGKSRDQLESLRFTSCPSTHSVPSNAAERSTFSAPPHLASLASLSSRLPTPSVPTPFSQMSGGPPSVIPMSHFPSADLSLPANGLPFQMPMLPFNPMITQDPQAFLLALADQLRFYTQTNTMPAPTDYTRNSESYLISEIKKSPTFDDIPIPEEPANMTREQATSLVSVYNHKDVNFAKGKAKPTTPTPVASTSTSAGRFIFVEAGKPLRFFIQIDLRDRTKLLTTIKKLGGKITNKQDDADFSILSPRSNTYASLLRSSLAVKTSAVGPSYVEDCAKESRLLDRTTYLLANEDKAKKGKEAKVSVGGPGEIPPERKRKASFNADEKDRAKKVKKESLRPMVNLSFRPSPSPPPEHARKRLDDGRYGYSTEELEYAVQYSEILLERNHEMPVSQIARKLHEKMPHHPVKSWTTTINQKNQYVRDKIADAKKRAGIAYRKACAQASSQNEGELEEDMHAIVYYFLYDDDADDADGVVWAKLSSKTPCRTSRTWQDFYELHGQEIHRRYDEVKGQEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1K5</accession>
    <name>A0A8H5H1K5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_000551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1K5"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="276"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5375048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="35229" checksum="0CFB8FA21EA650C2" modified="2022-01-19" version="1">MPPRGNDGLDFTPILTHYLFLLTSLLSILAWFIAFIGQIISTSRFGRESVGVLWFAIWLQLFLIAGVLYTLASDSIGMHRFQISVFGAVAIVLAVNGVEGIFSNQGPVEAMAVGWLILSMVDIVWVLYFTSEEDSLMLHIFNLLGTGGLTPPSRRRRARNQNSIHNMNNGYANNYASGGGISSQDIPYNKQMGSVVGSPGIGGGVGPNGIRSQNSFGAVSADARSLGAASVNNPPTSAGGPGSIGGGDNNGPSSPLMAGVGAVGQMGANDAAAAETYSYKAKALYAYTASPDDPTEISFTKGEILDIVDKQGKWWQAKKSDGSVGIAPSNYLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H272</accession>
    <name>A0A8H5H272_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_000106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="968"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1161"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="285"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="631"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="934"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1252"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5375060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1520" mass="168740" checksum="3D2763A9CC380F56" modified="2022-01-19" version="1">MSMAYGDLTERSYLGAIQCSTKDWLLSASWSDTRVYSAYAAIASVLLLLIHLTALISRDGPSESQQKPGNAPNPRSLSSPLVRLFLVILLVGISVQAPRHCSSPSPILLPDYFTSLTLVYVALLALFSLSSAYRITTVVHYHIQVLLLIILAVYTYRDIVPLFTYTSSPQDSCEGWLLWVKVSFLVLASIAVPLLASRECFTPDPNPEQKASFALLITYSFLDNVIHLASRSLQLEVAKLPPLADYDDAKTLKAETFPYLDVFSGANKTRHIFFGLMVIYRWEFLTLAAMSIIEIAAGFAGPIGINRLLNYIENDRQDVVMRPWFWILLLFVGSVSRSLASQWYEFIATRTVVRTEAMITQLIFEHSLRIRPTDSMPDDSKTSSTMSQETSPSRPEDSSSHSTNIIGRINNLVTTDLANAVVARDFLRLIVKMPIEIVLCVVFLYIILGWSAFVGLAMILLCFPIPGWIGNQVHGVQTELMNKTDSRVNSIVEALNLLRMIKLFGWERKMSEKIDQKREEELGWLWKRELMDLSINCVNFVIPIFTLLATYFTYTVIMKEELTASKVFSTITVIDMFREQLYTILASITSTVSGKVSLDRINDFLHKSELLDIYSNDAIQSLHAPQDVIGIKQATFSWSTRPASVQNDFSLTVNDELVFHQGGINLIIGPTGSGKTSLLMALLGEMNFIPSSSQSWFSLPRTGGVAYAAQESWIQNDTIKNNILFGSPDDVSRYRKVIYQCGLEHDLNLFEAGDSTEVGPKGVTLSGGQKARITLARAVYSSAEILLLDDQLASLDVHTAKWIVDKCLRGDLIRGRTVLLVTHNVALAGPIADFVVSVGSDGRVVGRKSVKEAIVQDKALQLEAKKDEEMLARANEDIDAESRLPGTAKSNDSETGKLVIAEEKESGHVSWSAIFMYFNALAGNHRIFFNGCFVVTMMISNLAINTQTYYLGYWASQYEDRPASQVPVFFNLGILAVILFCAVFFHVICRIIFFKGSLRASRSLHHHLLESVFGTTLRWLDTTPLSRVLTRATTDISTIDGPLHKVLFGLWNTISFTFIRFFAIIIISPIFFIPAGVLIIIGCWISQIYMTAQLGIKREMENRRALVLAHFGAAISGLVSIRAYSASTSFTNSSLDLINDYTRSARPFHGLTCWVTVRLDLLSALFSTALAVYLVYFPNSSYLNLDASLTGFSLNMGIGFSMLTLWLVQSVNDFEVQSSSVERIRHYTRIEQEPAPIASGKPPAYWPASGTLRVEHLSAKYSENGKEVLHDLTFEVKGGERIGVVGRTGSGKSSLSLSLLRAIITSGEVYYDGIKTSSINLDALRANITIVPQIPELLSGTVRYNLDPFNQHDDATLNDALKASGLHALQDQEDVGENETNVSVSAATTITTAEARVTLDTHISSGGTNLSVGQRQFLALARAIVRGSKLLILDEATSAIDYKTDAIIQRYLRTELGDDVTLIAIAHRLQTIMDADKIMVLEDGHIVEFDSPRNLMSDKNSKLRMLVDESEDRDELLAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGW4</accession>
    <name>A0A8H5LGW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGW4"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="12138" checksum="55477B216F507688" modified="2022-01-19" version="1">MGTTQGIYRINNGLSGFKTVTDAVREWVMKEQRRVGTEHTVKAGLQWGTSDGLLLIRPRPGKPGLWVCAGHTGHGMSRASVQHLPVMSPTPPQPGTTVADGAHVGGVEFFSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LH70</accession>
    <name>A0A8H5LH70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LH70"/>
    <dbReference type="OrthoDB" id="2943086at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="585" mass="64295" checksum="48D309C613EE0D6F" modified="2022-01-19" version="1">MTDVDLNDWVVVSRQWWRTPSTTVSWAYNQPKSSKRLYARAPHRPELLTRKDSTTSRQLGAGFHGQDEAHEMELNEGLVGVRGVFDVLSVYEGHVGIKVVKEKPQPDLSRKVDEKEVALHQTRWRELMENFVGDLPEQTSDSSDSEGSGSPLFSSFESSRSSVSSFEVSEWERDHSMSMPSTPKAKAPRSRLEDWVSPRETRSCNLSPFGASPSKRLNASAIAFVPQLPRPESQPAPSRNFSDSSPQTSASSSSPPLLDFTFPSLNVPSIPKLKIEKDDQGFYTGIEEDGSGAHSKTRTTALLPAFLQEESPRRKLPSRTRAMVDRLRSTPSQPILGPLDHHLDRASGSESEADTDLRSSTPSIVDDGEGWIDVDTSTNTSENSIAARAQRKRDLFLALNKHQRSESSLTSSTSPEQAEPPELSSSTVTEYVNDDGWIESIPQAQTKKFRRRPPRRPGAAKLAEISSTLGGTTPVFPTLNPTGPGSQEHKSRSSVPSVATPRAPVSQVPAPVPVSYVYGGYPVMAPMHYPPPYPPVMQYPGVQPALHQRTPSLVPPVGYAPSGKAPFVPPQPMYYPPSSGIRPMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHU6</accession>
    <name>A0A8H5LHU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_007438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Plays a central role in virulence and antifungal drug action.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHU6"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5357697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19892" checksum="E6C6CC63BB14E6CA" modified="2022-01-19" version="1">MGQSPSQFMEDMSRRSNFTQAELERLKKRFMKLDSDGSGSIDREEFLRIPQIATNPLASRMIAIFDEDGGGTVDFQEFVGGLSAFSSRGGREEKLRFAFKVYDVDRDGYISNGELFLVLKMMVGNNLKDQQLQQIVDKTIMEADRNGDGKLDFEEFALMVSNTDIVKQMTLEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQE3</accession>
    <name>A0A8H5LQE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_005772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQE3"/>
    <dbReference type="OrthoDB" id="2931494at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5366155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="593" mass="67114" checksum="6C11B484F460824F" modified="2022-01-19" version="1">MSESLQVALRNATIYQPRAYLTGLPPSEIEKLQPRLPDVAEVRNEAPRALKMMNEPPPDDIQGLDQDGELLGVLHPSIAYHFLFPKLYAFSYFCHVDDVPEDLQLLCLWALQHKVVALTEGSQKQLRRILASPTGNILPGSERFMEGQARTKIVSNLLSPRINRPEEAIPHIEAWMKLDAVAKPLPNDVFLRNPHCYVLYGSALARTKTNDVKAKTILERVLTDIDQVTDGSKAISIEAKLFLSRVLRRMGEVDEAKKLEDYLVKWFKKNPKRLAENTLQQWFVTESDADPVLQGLGGEAWFTKKPTFKNLDRQARKCYNCGQGESASMKLLRCAKCQYTYYCSRKCQVENYPHHKVGCTERAAEIKRAEALKATAPDDAKCIEDWGHYKDSGFDDMPSFHALGLMHDINRGKNHIIFKRVKYVPDGGKDVLDRFRVVAVGVFRIKDVLRDIEIVLAYNRGEGEQVIKELIDEFNQGPGKGGSVPFFNLFMSDDKRMGNYLSIGGVNPEKVQGIKYDPDWRKLLNRKKCNVEQLQLRSGAKDAERDYTPSEARMTDEPEAKDPQQSDGHKPSQPKTESASPAAALPKLRGMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRD5</accession>
    <name>A0A8H5LRD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRD5"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000034">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="17637" checksum="0EB23DE3576E5B7A" modified="2022-01-19" version="1">MPRHFLAEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELHDMINEVDADGNGTIDFPEFLTMMARKMRDTDSEEEIKEAFKVFDKDGNGYISAAELRHVMTNLGEKLSDSEVDEMIREADVDGDGQINYDEFVKVMKPFPTIETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTH4</accession>
    <name>A0A8H5LTH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTH4"/>
    <dbReference type="OrthoDB" id="2903551at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="250" mass="27803" checksum="775D0306915F7DE8" modified="2022-01-19" version="1">MSPSNYSHSIHDGHVHAREDQLLDKLDLQLKGFPEIDATPSTGITSLPTPRNEPVELTDAKEADEANEYVVYLSGRVPLTNIPPSILQPLLPPSAYEAMECPGAPRVKDLDSFTDGTGGSFDFLTGIAEDDTAPPLNSLALSNLPPQNTSLSIEMWREDVYYHSPSTDTPTARPEASDESTLPSLAHVKRPRSLASDDNVDDRRIRHRVQSDIAPSIPRPLFYDDRLYTTFPEAMPRLRRSRSLPYRPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTH9</accession>
    <name>A0A8H5LTH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTH9"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="245"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="498"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="726"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="907"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="981" mass="109910" checksum="95C210A3C96DA2F6" modified="2022-01-19" version="1">MTSTLGKRKERDEEVKHGSTLFVSNIPYTVTSTDLQTLFSDIAPVRSAFIVTEHGTGVSKGVGYVSFSIREDAQSAYDKISQEGISLAGRQLRIQWAENKPKEKGEKVKKESKPTPIPRPQHPKAPHDPLAIRTIVVSGLPSSVDSRVLWKKFRKYPGAEKVEWPIKFGEEERTDTAHVLFDTPVNALNASAKLHAHVFKGSLLSAALKKRLDNLQKSATDELKKPGSGNSKKGKNASNAPSHASRLIVRNIPFNTTEQDLRAIFLPYGPIYSIHIPLEKVKDVDQSEVDEVKEEDVDMEEEGAGPSNSPKKNNMKPRTRGFAFVWMISKKDAEKAIEGCNGTVVRGGMAESMVEDKQKRKKQKRLEKKMKMKQQDKEADDEEVQEGEDVELTGDERIIAVDWALSKDKWQEEKAKMEVIKSEDEDEDEEESGEESQSDTDSASSEEDEEALGLHDDDDDSSSSSHAEGNSEDEDSQDEDAHSDAPVKPQLPAPESGTTLFIRNIPFTATEDELRTLFRAFGPLRYARITMDPDTGRSRGTGFACFWNKEDADKVIEQSELLRSETMGASDSQQTKKNPFSMPSILTPDPSSTLARSLVLQGRTLDVVRAVSRDQAGKLKEEGEKRRQKADKRNMYLLREGVILPNTPAAQTLSQTDLERRTASFSARKNLLKTNPSLYISKTRLSIRQIPIFVTEHMLKRLALYAVKAFNIEFKNGERAGLTADELNDGIEVEEGDVEDEAVDAVKKEKEDDDSEEEDESDDGEGTTEKKSKGKGKAKPSTKKAAKRLTGVKQAKIVRQQERVDPVTGKGRSKGYGFVEMYRHADSLRVLRWANNNPKVGELFEEWWKDELKMLLKAEKQKPQKDEARIKRIQGEIENGEGKKSKGALIVEFSIENVQVVQRRNAKQNDRGKAREKPKTDVKQEKLALPKPQTEESPRKKPRLAKGKSENSEQKPAKPGQKIGFLIGRKRKERKGGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTS3</accession>
    <name>A0A8H5LTS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTS3"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="287" mass="32298" checksum="537642372E4EE7D6" modified="2022-01-19" version="1">MPFRPSYASYPNPQPNQLWGPYYHHVDHTQNPQPSNNPLTNVTNTLPIPQPLPNNTSTPHAQPIPLHPKRPSHTVHCKKLEQHALAEANLPAVIQCTLKAANTNRHKEREVGLFCNWCSTSGKNALPASKTTLCKYTLHYARKIAGSTVRQKLSALKTWHVQQQLPWNRNLLLRNTLKGIDNLTPASSFRPKCELVTLNMLHILHYDLIDNTNTTRITKGSKGFRRCVYTASTALFAGQLWQKEVLVGTEDPAKYQPLLLPTVGNLSKVIESNSPIQTELPSRSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUH0</accession>
    <name>A0A8H5LUH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUH0"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="211"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="425"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="685"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="903" mass="99380" checksum="39A0B7F6FA4BAAEE" modified="2022-01-19" version="1">MSNVQDATDASKSTRNGQLMALPLTALAVGATIGFVRGARATGLRFLAENAHRPPRTVKGWYFYNKTKNYRVLLGGMQSAARESSKLVGISLVWVGVEEAVRRVDEGGKWGSVVAGVGTGGVFGAVYRLGVRTTSQTVVLGGVIGAIYYHLAMDILTPRATDYSLNPFDAHPLLTPTRSPSAYFHVNDHTPGTPGSFAASIPTTSLSLHAPDFNIKMPPSPRRPEPSSTSRGQIHVKLIQARGLNVRATSARPYVVVQFEQNEFVSRDPTDESDKEVKGLPTKNSSSALSALGAIESKVAALDPTRKSKGGSNGSSPSSSLGSSKGGGLFSRLSAHNPVWKHEVTFDVTNANSLVTFNVYDRSVSDHGFLGTLQIKPVHVHEQTIDQWYKLRPYENESQIVSGEIRIQMTFEQLKTKRALTPRDFEFLKLIGRGTFGKVFQVRKKDTKRIYAMKVLSKKEIVAKKEVAHTIGERKILQRSLECPFLVGLKFSFQTDSDLYLVTDFKSGGELFWHLQRETRFTEERARFYIAELVLALEHLHKYDIVYRDLKPENILLDATGHVALCDFGLSKPDLKPDELTTTFCGTTEYLAPEILLDEHGYSKIVDFWSLGVLLFEMCCGWSPFYAEETQQMYKNICFGKIRFPKGVIGEDGKQFVKGLLNRNPKHRLGAQRDAAELKDHPFFKTIDWNLLSEKKVTPPFKPVVESDESTTNFDPEFTSADVRDLNGEEKLDEADPSADWVSQSVGGNGFAHTPNGPLGSEKTPPQTPSLSGLTSMNGHSNGASGVNGKSSSGASLTRNESAAGRSAKGVAINGKKKKDADAPGSTPLTNSVQENFRGFTYHGESVQQHADAFTSRLKDKYVDNEDEEPHEVTTEDEFEDFGKSAGRYANMRKKGLGMSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUV5</accession>
    <name>A0A8H5LUV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUV5"/>
    <dbReference type="OrthoDB" id="3271097at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="400" mass="43062" checksum="B35E82314F69F38E" modified="2022-01-19" version="1">MPKAITPQGNAAATKPYEKDPGSTDPKGKRNAAGKKTGTAGGQGGRTKKKSAEETDVDMGNTGAKINEKQNPRPAQKKKINTNASVAANRPVDVLGEITNRFLGDAGDTVTDTPKDQGTAGLPDDEDDELRRTEARLQELKARRAQRQASVAAAAAEASTDGDAHVSTPIIASAALTPNTRGTEAQVPAPQPNPAKANPTPINPAKSTAAKQKMKVTVNNNRQKPALVTANTPQSVTDHEIQKIDRPDGEPGNGRTGFNLQSACGLGDDDNHYAQFGELLRSACKQVAVDYSKTFQQQDSDKLYLVKKKVSNKDTYFCKERFEGLWPIRDYMKVHINNARKHKKRKENGKFVSKKKAKVVETGTSDATPEDTDDDVDMDKPGEESEGDGNDGDDTAELNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUZ6</accession>
    <name>A0A8H5LUZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUZ6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59646" checksum="7E762B6030D09F9C" modified="2022-01-19" version="1">MLDLQAFVAVALALGATFLIANPDILRRPAAPLPPGPKGTLFFGNLFQIPPKRQYLQFAKWKEDYGDVMKVKLLRKTFIILNSRQAVQALFVKRSNIYSDRPALVIFEKYSGWNWSLPGLHYGDEMMLHRRLLNSGLSTTACKGYFNDMLTAALKLALKAGNNSETWAEATHLMVAGNILKMTYGYDVQEKNDPWMDRAEKILHLIQDLGPIGTHPADVFPWLANLPARFFGQKFANNMHQLRQIVTAVWTDPYNDVKQTLDSGKERPCFTADMISQYCAEDGKVEHEHAIRATAATNYTVGVETVESSLNTFAIAMMLNPDVQKRAQAEIDDYFHGQRLPTLEDRGKLPYVEAVMWEVLRWQPATPMAVARMMAVDDVYNGFLIPKGKQDFRAAVMANSWQCLHDPTDFPNPHAFIPDRFIPTSPFNPNIDKSISPPDPRDFAFGYGRRACVGRPFAEATLWMGIAMLLATVNFEVPKDEFGKDIFPNMEYESGVAVQFPKPFKTNIKFRSKVDQDLIQETLDSMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVW1</accession>
    <name>A0A8H5LVW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVW1"/>
    <dbReference type="OrthoDB" id="3250682at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="36156" checksum="1DF63CA1BC75B0F6" modified="2022-01-19" version="1">MSNIPVISVSLASLLTETFLYGCFFLLTTISMILVFVPLETKATALSCERRSFRTIIKRPMFISAFLILLSVTAHWICSYYRSWQAFITFEGGTQSAYFYADMSQTSQVAKTGTLVFALLVSDAMLIYRLWVVWDRNWKVIIFPILTLISLTICGFGITYQFTRYVPGMDVFDSAADRWITSDCVFTLSTNLYCTCFISWRIWKTNDALKALGASNLNNILVTFIESAMIYTIWTFGFFVSYEAHSNIQFIFVDSWAAIAGISFMLINVRLSLGWIRQSKTGCGNTIAIVTPISVNPTGLPGHPNGIQIPFSVHVFEKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LXJ2</accession>
    <name>A0A8H5LXJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LXJ2"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034156469" evidence="2">
        <location>
            <begin position="22"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="720" mass="73907" checksum="C629CCA2AF3C6B55" modified="2022-01-19" version="1">MFSKIFTTVSLVLALSVHVNGHTLIAPALGVQGNGVRNDVQRPSAANACGNVNVAQTIDSSTPVAAAADGTFTATATDFNAGADGSRQVSATVDATGAGKTFNGKVTISQNGDAAPTAVGSQQIVAALPAGTKCTGGAAGNRCLVAFKTTAGFGNCVVVSQGGAAGTAAGTGAGAANTGAATGAANGNATTGAATSAANGNANAGAANAGAANAGAANAGAANAGAANAGNANAGAANAGAANAGAANAGAANAGATTGAANGNGKGKGRGRFGNGFGRVAGTRTARALLSELEARGEESLDVVKRNVLGSSLPPSYSVTPIDGESSLAHNRRVHHHGTYTRKCGNVSVTLTEQAGDAIMPVYPQRGVVSGTIHLGSCHHISEVLLKFQGRFKYSLSGYNASSRSIKTVDEKYVLWNLDISSQGTAPSSMPFSVIFPFTFKDGNDEAPLPPSYETSEALSGVSAKSEYKLKVIVKTSKTLWVHNKTVTVPLNYRPRKRPSQPIMPPSVAFFSSVKTCPEEWFQASAVLRTNEWSNLAPLQTHFFLPAVRVFALRDTIPFHIQLTGKLSSLKYLLSHLRTGDLPEQGFSNRTTDYSAITMSVAIHRQVSVKVNDQVAWQNSVIGTGKMRAVPPPFDSNLASGNFTSDSDGEPEESLDWEGELKINDSIRVGHFDAGNVAIKDFIIFSISGVSHFPTDFVALRNTVAIAVVTDPWAENNTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY15</accession>
    <name>A0A8H5LY15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY15"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="224" mass="23825" checksum="F7364B8C8FA57FD8" modified="2022-01-19" version="1">MRLLILGATGPVGILLAREALTSLENCSLVLYIRSPDKVPEDIKSNPAVTIIEGQLTNLESLSGAMEGVDAVLSALGPSVRKGPFHPSGCPLAAAIENVIQIMHKKGIKRLIVLGTASITAPEDKPDIKFKALVTAVSLGAHNAYKDVVAIGENIKKESDLDWTIVRVPLLTDKEKRDVVSGFIGDGKVGTTLARVGFGVFVIRGLLKMNNSAWIRKAPVICTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B655</accession>
    <name>A0A8H5B655_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000477">
        <property type="protein sequence ID" value="KAF5317480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B655"/>
    <dbReference type="OrthoDB" id="1715602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF104">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5317480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="205" mass="23723" checksum="9949279606D4D4E0" modified="2022-01-19" version="1">MTDESAVYRIAMVLHPGLKLEYFRRRKWQEPWIRQAESLTREAYNEYAQRAQLLQNSVTSTTDDEPATSSSSTTPQPMQFHDFTNISVAPSTTVTVRDELADYLAMPLENVKDPLMWWWEKRTVFPILSQMALDYHSIPATSTSVERVFSFGRQLLVFTRNRLSALSLRRFLCLGSWSKKDMIQDKDVLDALLEADEKKEGKKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BAU7</accession>
    <name>A0A8H5BAU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000423">
        <property type="protein sequence ID" value="KAF5319881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BAU7"/>
    <dbReference type="OrthoDB" id="3270175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="799"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5319881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="936" mass="105274" checksum="ED7F387A5D690743" modified="2022-01-19" version="1">MYYHVEPHRHRIPGHNTPQYNTAATNFKLRPLRNQTIPIPKTIRKTWKTCKIFLRELFPIPWSFDPDTSVLPPPTWNPAPDHSASSGSIKNAFDVLLANQCSPATIVAGHRHSTRPRRPSAKILEARNSENTKGKCKASPEPPTRAVSCKVSESASEYEMIDSDGTQSDHIATDVQSEDDDDDVEIISYEQMKTIGTSDVVMKVSKSNRTIDILVIFKKTSDTNVKQAGHSCGICKRKGFPSKHYFFTGSVTSLCKHIARNPDHFIVYKTECEKRNIEMHPTAIPASSGDFSRQSTLDMVVVKQPTVEFSVAGLKDYIIALVVIEDTAMYLVSKPSFRQLLQFCRPSLKDKDLISPTELCREIIKRAGADVPSKVSFTFDLWTSDPSDPYLSATCHYIWAPKDQPTEWELKCENLAFAPFLGHHSGANQAAVLLETFKKYGIDCKKLGWLTADNASNNDTALTNISFEMNNYGAIDHNSDEFWDPTTHRIRLELIHFRCMEHVVHLASGAFIKGVSPASKTAVLDNSTDNEDNDGDSSDANDDLTAGDAVGKLLALINQIRKSPQAHAFFKECCIKTNNKPLELMLWIHTHWASLFAALERAIQLEKTADDDDKVPKLRNKAYCDYRLTRAEWDHLKVVHEALSLPAKATQSFSSARHPTLLKTIPTLEYLRSMWVSMAVEKRFESVKGALWQGIASIDKWYNKVDHSSAYFITFVLDPTVKLAYVSDKWDASWVMAGMASLESEFDHYYIPPEATETSAATVSNETVQSSGFGRGWMMASIQNRVRADAIFNSDPRAELRRYLESPLEPLINPDDQKELDIVRWWGCFLKRHQQAYPTLSRMARDYLAIQGSATPSERAFSSAGLTDQKRRNRLSPATFSALQTLKAAYRNGHISAYQQAAEHIKDFMETLDEYYFGGDESEDEDSNESDASASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BYZ3</accession>
    <name>A0A8H5BYZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000315">
        <property type="protein sequence ID" value="KAF5332040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BYZ3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="44317" checksum="A7BAA7E5B9D2E906" modified="2022-01-19" version="1">MGDLVEEGGMGGVGDVETTLEKREREQKEYKENQNQKRPSLSMLSPKRTFPSSSSSHINPVLSSSSSANHINCISPEITQAIQTFKKGFSKSNLGTERAPWTRGRDGFGGINLLGVGFASGSGSGNTSTSMSTGTSGNGRTRTMSTMSGAHGDDDEVKEDSGGGSRYEAGSGPGPAALGPGMISDNTHVLTKTNSTLFPFPRPFSLCRVVSCVSSGLTQNLTSNLTFSLAPGWKFIETEDWRVDYDAGAGAGATSTFKEDKVASPLSTDAEHGDGDSEGDEDADDDDDGGEDGGDEDDEFGNGKSGRWLDITFKAGVRKRTRPIGPIEPRRGQIYQARQTRQSRQGQEDRQEGQEQWEQQEHQHKLEISFSIVFGVSVDVGFSFWGRGGSGVGGVNDEDEDQGWMCGGDEGGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C240</accession>
    <name>A0A8H5C240_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C240"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="9587" checksum="C71262C97E4941B1" modified="2022-01-19" version="1">MIHLPPVSSSNPFSIRIRVDATIASRFSLPSSSSGDSSDSSDTGSAYAIELNSDPLTPQPLPPSGLATYISPLLPADSVDHNLIYVSGNTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2A8</accession>
    <name>A0A8H5C2A8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2A8"/>
    <dbReference type="OrthoDB" id="2901006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="9578" checksum="CF38129B7E4942B2" modified="2022-01-19" version="1">MIHLPPVSSSNPFSIRIRVDATIASRFSLSSSSSGDSSDSSDTGSAYAIELDSDPLTPQPLPPSGLATYISPLLPADSVDHNLIYVSGNTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2W2</accession>
    <name>A0A8H5C2W2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000271">
        <property type="protein sequence ID" value="KAF5334069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1320" mass="145191" checksum="C80D3677C92C092D" modified="2022-01-19" version="1">MTSVPVPPPGLQPPFQPVPGSRRAPRGANSRFTRPLGEFLPADDPPLADQAFGPAAQGGPLDPEASIGSNEEFPEDQFIEPESPRLPPTPPGPGPDPGLGGAQPPRAVSRAASSPPTFPRRRPLGCDVSVHSEDDPDGATKHPKANSSRRPNQGGASHAGHISPTGRPRRGTQSSAASHVSEDDGPNGGGRSPTFGGDGPRQPSAGPSRRRDEDTSIPESGTPRIPTAAKGKGRAQQPSFRSQPGSHDHPGPSFPQQFHPAGHGDFDDPSRRRPKCSRKDPGARQKYPASDDDSDDNSTPRRNTSPNLPRSDPSMAKNPNSSSSSSSSSSSLSLSSSSSSVSESKRRPLPNSAFNMSTVVAHNLRDHWRHHLSLTHFTARLMRDFLAVLCSNEGLITSPFIVLLQESDLPDIARNLRPVIIQNYRYKRGKDVGLGTARWVADRWYMLIMAIADSETLYDDFPTAVLYLQRTLFDWEASSEKWTISVSPIREPVWTRYHHTIVSQCAHFAKILPTVQAVPSRPFRATTSEPSLAGSSSSAGCVGFLTTTKSTGPDPAISSRNLEMLSKIPSSICTASVTTATAALTPRVSTNISVANVAPVTIPLKPILHPTPLPDPTPLPKNHNLFPVVTRLRHEAWTRLLIATDGYEKFKKVPEGLRDGFLIGVEDYKLSHTFTPKNHPSASTYSHVISEKFNDEIAKGRISIGFELSYLESIIGPFRTSPLAVIEQKPGKFRIIINHSYPHTPPHIQRLLNPPSSSSSTSSTSCATDHDPSLIIIDPEIYSVNSLIDTDKFQCAWGTFSECWLLIANAPPGTQASVFDVDAAFRNIPIHPSARNFVALLFNGLVHLDQCLNFGKASSPGIWGLVADAMVHILLNSGVEALIKWVDDFIFFRYPRLSLGNGIYEYAYDENLVWSIAEELGWPWALLKFVAFAVFFTYIGFFWNIEKKTVELPQNKKTKYSMKISTFLSSPSHTKEDAESMKRSSSLPPKFAVEPHFNTLRNPNLSDAAAAAIAGSVVSETRRRQQLIVTEFAVWANDMGLHPDEVLPAPETFLCEFAASFLGRRAGGTVKAKISALKSWHLNLGFKWNGADLLRRALTGIDHQAPPSSHRPERPPVTKDMMRSLHTACILGQLRCGELFPKNSDPRLFDPSKHPRVQDVQELPPPTPQSKYGPMAMFLPSTKTEIFKGDEVHIHAYHGSLNATKATHAHVRANRLSPQDPFMSYRDDSGKLKVMTKSYFLALCNEVWEKEGYPRFTGHSFRIGSTSLLLQDSVNPEYVKMCGRWKSSAFTRYWRDLHTCATVHIDRVHARNRLHQCLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4G4</accession>
    <name>A0A8H5C4G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000256">
        <property type="protein sequence ID" value="KAF5334584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4G4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787777" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5334584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="573" mass="62246" checksum="C84822EE3FBE38AF" modified="2022-01-19" version="1">MRLPLLLLAFELPFLVTGSAPTAVIGDVTFTGRRTSDNVEFFGGIPFAEPPVADLRLKPPVPKMFSSGQQATFNATQFGPSCVQTKLPPEQLSEDCLSLNIFRPSNISSDKSLPVMVWVYGGGFIVGSSSRYDGTPLVNRSVSRGTPTILVTVNYRLGPLGFPRGEEVFRDAEAGSHILNLGLQDNVAALQWVQENIASFGGDPSKVTVFGESSGARALELLILNGEIEGLARGVIIESTARIPDVIPQSPAANETWNNFMSALPNCVNSSLSDIECIRNLTTADLINGYNDAGIFFSFAEASEWTPTFGDRHLPGMPSTLMPKKKVVEAVLIGTNKDEGTLATNQSVNTDQVIKDTILGSPPSPPNATQSEREAQLNKLESILNKTLALYPNIPSKGSPFDTGNETFGLDPQYKRTAAVATDYVYNSERRYHINNQLLPAGISTYSYLFTDPDAVPMRDFVVGTPVPGSLGVSHTSEVYYVFGIISEQPEVPEVTPTAAKLSDMMMDYWISFADTLNPNDAAGSDRPEWPEYTTYNPILLELNGHNTTVVLDNLRESQVALFVDDPTVLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C4P2</accession>
    <name>A0A8H5C4P2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C4P2"/>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="510"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5335031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="594" mass="67110" checksum="5DD50F0807B4ABAF" modified="2022-01-19" version="1">MKREVEKRLTMLVLQTKESEHIEEVKDEEALPKPATKQANKVPGSNSKRTDAIYLFYKQVPFSASGVEGNPGNQHFFCLHSNHKVFTVSKKMNACLHKTYLDASGLKHHLKSNSKHLYQFFEILQGSKKRGVVWTKDDIEVAAGCKAFDQEFTAALDAEIDEHQENIKDAFTKQREAALEPWNQERFEELLVKWLVASNQPFSEVEQVEFIELLQYVHHNGGKLRILTDDYQRDSGDILVALSIDTWTLSNQYAFLAIATHYINEDGQLGMEPEDNKAVELDGVEEDSFDELKQDGVAPSVAKVISEPQLFCALMHNFSYIAATFIVRHAVTYKEAIDSYASQQLDLQDCLLDETDWANITKVTAWLKTFCVATLQMSTTKTPMLSSTLKVLHSLEDDVKEIISSLGPWDVSDDVCDALIAAHGKLMLDPHIDREALEADYEKDATLTGHLTKSRQELHEYFNSNYVSNCTPLVSSSSVPGPSDVLHIDGSPQKKFKSKYHQKVDAVCDELTEFWKQPPEDSEKCDPITWWAGHKATYLNLYCLALDIFSIPGSAVAVEHVFSGRRDTISLRRASLSVDTIRLLMIAKHQLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C637</accession>
    <name>A0A8H5C637_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000244">
        <property type="protein sequence ID" value="KAF5335266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C637"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF199">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5335266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24679" checksum="9BC8E71542632324" modified="2022-01-19" version="1">MSVDIVKGGWSQEEDECLMKAIERYGTKWSMVSSMVKTRNSDQCAKRWTDTLNPSIDRTSWTIEEDALLLEAVQEQGNVWTKIVKTYFPGRTGLAAKNRYNSITRFTTDSHVARRKTSSTRKSRKSRRVSHSPSTPSESVLSPSTRESSWSPDEPSPIPSGIFYTQPAQSTRTSNGPKPTVATFERCSNRKACARAAIPFLTERTAWDRRVSEFCSSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C704</accession>
    <name>A0A8H5C704_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C704"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034904453" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="241"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5336306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="54027" checksum="2B0DBC89818E4A97" modified="2022-01-19" version="1">MKLTVAFLLVSATLTTLASGVTSNTESDAPIVDLGYASYQGSFDPSTNVTNFLGVRYAAAPLGDLRFRAPQSPANVPGVQQANTEPPECFQASSGLSPTNPFSNQTLAKRQGREQTEDCLFLNVAIPGSTIPTGEFPVIVWIHGGGYLGGDASDFHGSDLINEAKGGVVVVTIQYRLGVFGFLAGKQVKQNGALNAGLLDQHFALQWVNTHISKFGGLNSKVTIWGESAGAGSVLQQALYSEVVAQTNCASSSNPLNCLRSVDANTLEALNTNINSAGFFGLFTFVPVVDGEFITQRATEALKQGKVNGQALLAVTNTNEGLIFVNQTANQNTTFYAEQLFPNFGIQQDRETARQYAGLGSQLNQINLIQGESIFICPTYYLLNAFSGRSFKGEFAVPPATHAMDIQYYFPTGFTSSPFQNADFQKAFSQSFLAFAISLDPNSKFDRTNITPRWNKYSAGNTEMVFNSTNDGSAADIHTISTNRALLERCSFWESVGQLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBG7</accession>
    <name>A0A8H5CBG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000199">
        <property type="protein sequence ID" value="KAF5338184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBG7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="334" mass="37120" checksum="A9C85F2BAD836516" modified="2022-01-19" version="1">MVLGFRQLQASRSNALRRVTNSGPGRCHHHTRPNFAGGLQSEYVLNSGDKIPSVALGVWKAKPGEVGQAVKTALGAGYKHIDGAWIYRNEAEVGQALKESGVRRGDIWLTSKLWNSFHAPEDVEVTLDDSLKKLGTDYLDLYLIHWPLALKKDGKPYDKVLTDYPYPTWQKLEEMVQKGKVRNIGVSNFNIRKIQNLTANPLKIQPAVNQVEINYFFPQPELVKWSKKSGILLEAYSPLGSDGRVSDSLNVPVVKEIATETGMTPAQVIISWHVQRGTIVLPKSVTPSRIAENIHLSKLPDAAFNKLEKAATSHPPQRGLNPSKGWGLDFDVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCF9</accession>
    <name>A0A8H5CCF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000202">
        <property type="protein sequence ID" value="KAF5337987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCF9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="80" mass="8844" checksum="96D59CFAA1C643F7" modified="2022-01-19" version="1">MELTKMNNFVTIIASTWYSDADDDATPALAPFNFHQDSVTSFSISEPPPSESKFRDCVIVGNREELGVVEMLVDVSDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDS9</accession>
    <name>A0A8H5CDS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDS9"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5339904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56669" checksum="606893CCE7FFBB39" modified="2022-01-19" version="1">MTERRSASADPKLRCANQPHIFHPASNQDACYIPENGDNPWVPCKTQPCLNRYNTQRLIDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTNQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNNSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLAQFNNYLRMNEGRYPTEESRVSLFLSFFTGEKGGDWATQRLTERDDDEEDEELKTAPDQRRWITLKEIRDRFKRDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWKNFDQYQERAVELHLEWLKERERQGRWKTTLTPKNSPGPSQGRTVASVNALMGSGANSSFNLPPRLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQSTSRTFPSRTIRTTETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDVMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CES0</accession>
    <name>A0A8H5CES0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CES0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="207" mass="22855" checksum="77BA9C1F4A006FBA" modified="2022-01-19" version="1">MLSNNLQSLTLSWRLSSPNPLRLLHFLHPVNGANVTDNHGHPPSPVSPSSPQNNLNARDNDTPPRPHSPSQARVKDTPTSDHDTNPYPNGVLEPEPLTSEHLQPSNPSPSSPKRRTIKSQMKPRSPGPLKHAPMKPMKPMTPNRMKAMYNSVGKSMFEQPDSTIQQFSDDGTEPSASQISQFESPEKTTASGDSTSTERRRIVESWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGF5</accession>
    <name>A0A8H5CGF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000168">
        <property type="protein sequence ID" value="KAF5341300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGF5"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5341300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47304" checksum="BF86119326163693" modified="2022-01-19" version="1">MILLRALIIDRQEENEDEKINREEDDTSGYVYIPTAVFSRLAIKLGVYLRMKSEWPRFEFKEKVVFGPASAVKPNQYLVSETSHCSNMHTTLPGHSFLVNAFPASARVDASLPLTVVSRYESTTKHTNFAKFHEGFGKNLKLGIHQDAQNRSKLAEFWRFYLTKATDEQTSLKDYITRMPEIQKSIYYLTGESLAAVHDSPFLEVLKKKGFEVLLLVDPIDEYAITQLKEFDGKKLKEGLELEETEDEKKAREAEEAEFKELCTVVKEALGDKVEKVVVPNRITDSPCVLVTGQFGWSSNMERIMKAQALRDSSMSSHMASKKTLELNPRNPIVKELKRKVAEDKADKSVRDLTYLLFETALLTSGFTLDEPTSFAKRIHRMISLGLDVDEEEEDAPAITEAPASSEAALTSAMEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGT9</accession>
    <name>A0A8H5CGT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_014749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGT9"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5341434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42174" checksum="25799D32E864D4BA" modified="2022-01-19" version="1">MSIHSYEQTLTAVRQFQGSFEALWLFKQSVKDIIYRQARNSIFSLKAFLRLAFFSSTPLKFLFPSQSHGDFRSRLLSSSKAASAPSQWQVRAKLARECKVGSSINSSYTNTHQILRQGLREPAAEFAGVMILVIFGAGVGCQVNLSANTGVASSPKGDYTTFAFGWAVGLSLGVWVSAGISGGHINPAVTLSLAIFRGFPWRKVPAYIIAQVLGGIVGAGLIYANYIHAIDIIEGGRGIRTLSTAGIFSTFAAGYETNGCAFFSEFLTTALLLIVILAATDKRNCPPPYGLLPLVVFILTLGIGAALGMNTGFAINPARDLGPRILMAMVGYDSEIWHFRNQYWIWCPIIAPILGAMAGTIFYDAILYTGQDSALVRSTTSSDFFGDIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJ81</accession>
    <name>A0A8H5CJ81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000156">
        <property type="protein sequence ID" value="KAF5342786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJ81"/>
    <dbReference type="OrthoDB" id="2859046at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="264" mass="29101" checksum="83A41A0A1A213F6E" modified="2022-01-19" version="1">MQEFITADSIVVWRALCLWPEKTYYLRDIFGFWIFASACIAIADGFNTVVINIRAAGDASKVDGWQRLDSSSMLVSLSVNFAATTLILVKVWQIRQAWGTTSLGKSVPYRILIILIECGFFFCAVQSFAVISPILAGIYPSIVLLVIQQQSSIDGTNVVIYDITISNPEKDGHGDSNGHNHISVIGFTNQDSDLESGNRNLMAFWSGENLLVGLHGHHGHHGEVSTGGASNKDYAVIKRKRLDRTELSKSRAKVTLRLARTQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJI2</accession>
    <name>A0A8H5CJI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000153">
        <property type="protein sequence ID" value="KAF5342889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJI2"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21078" checksum="FB6D37D81B8E0819" modified="2022-01-19" version="1">MTTSHQRIMIFANQLLAKEERGEELDIRPSIGVTRAHSIKLSELDEAVRRGEIDVDGKIVMKNRPAKREDGSESESESESIDPGGEVAVSKAAVEPVWYSPGAPGRFGISETLLRLRCSLFEQTGRRTYHAPRHQNLTSPIGNFTVYIFGDPPSPPLHPTYTSLPKSTMNAMSLMSLGMISVHANRIWCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJZ0</accession>
    <name>A0A8H5CJZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000148">
        <property type="protein sequence ID" value="KAF5343142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJZ0"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="679"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="965" mass="105556" checksum="E48B206B828DC264" modified="2022-01-19" version="1">MSEYNIPLEEPTRGPATDVGADRTLTPSTLSYHEDEAAELEVAIKNMSLEQSNAEATEDSSVNDTPIDMEQKVMTGLDSLIKELNNSAVEQLKHFQESGDCAAIDDAVQLFGEAVNLTPESHASKAALLTNLGGAFQHRFERLGELGDIKDAIQHSSVDLSVLESSGDIKDAIQVGQQAVDLTPDGHAHKAALLNNLGGALQRRFERLGELGDIEDAIRVMRQAVDLTPDSHADKASFLNNLGNAFQCRFQYLGELGDIENAIQVKQEAVNLTSDGHADKASFLNNLGNAIQCRLSNLTPDGHAKKASFLNNLGNAIQCRFQCVGELGDIENAIRVKQEAVNLTPDGYADKAAKLNNLGGALQCRFERLGELGDIEDAIRVLQQAAEQPGGALQGRFEHIGELGDIKNVISTFQQSTKNTCGPPSIRYHAACKWATLSSAYQDSSSALDAYKVVLEIIPQLIWPGQTVHQRYEELPKIVQTINAAVATAISAENLTQAVEWLEEGRGIVWGQILQLRLSLDNLQSGEDFYSATKCWTSTHSDTINNPNTHTDMTGKQEAQQHTQLAAEYEALIAVVRKLNGFDSFLKPKKLSALTPAAVNGPVIIINVDQSRCDALVLSSSHSTIHIPLPDFSSKQAEEMYSEMISSLQDSGVRVDCAEEQFSVMQQAEMGHDQLKSILARLWSTVVQPIFSEIEDVLHDSAEGCLPHITWCVTGALALLPLHAAGIYGSKDPSDDINLSDFAVSSYTTTLSAMLKSGHKPHQRDPRDKPKVLIVSQPDTKEEARIIQTYTSPEHSCHLTCEEAVVETVKREMGKYEIVHLACHGIQDSKNPLDSAFTLYDGRLKLHDLMGLSLENVELAFLSACQIVAGNEKLPEERVNLVAGMLAVGYPSVITTMWSIGDKDTPVPVVADKVYESLLGHRNELETRNLRQSAAYALHAAVKHLRKEVGEMQFIKWVPFVHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLB8</accession>
    <name>A0A8H5CLB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLB8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="341" mass="37762" checksum="FF6A39C73B75886D" modified="2022-01-19" version="1">MFFAGSQGYRPSAILLNFLPPPHQTPPYVPPLSDHSYIPPALPFRLTTAGVVVERDHDITLGRVFRSNAFREPSTLVSRALPTNSRLFSHSGGLLCAVRSLQVKRTSIHSSLTPPGSTVSTFPPLTLQPGSPILLGAFYSSILPTFRSFLTSSKTTPPSSKFSPPQPRSFDDHPPPCAVPIPSEAQNMVQHEWPLPRHQHLSTKAHEPCTNLSDFYAKQDDMRWRRPSCDGLRWWWYSSLASASVLPSRFDDIDHHDAPVVSEPVLRRMEVASSSNCKTEDIRYGAVSKPNGTILDSLLEFPGLRSALVVTLGDGMQYPFSLSSRFFFVSIHVNPQLSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLF9</accession>
    <name>A0A8H5CLF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000136">
        <property type="protein sequence ID" value="KAF5343653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLF9"/>
    <dbReference type="OrthoDB" id="10632467at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="706" mass="73759" checksum="B8DA66E328D7EFAC" modified="2022-01-19" version="1">MNVPVLVISTLHGFTTTRTHVVGSPPSRSRPGLGVAGRSMSYSGDGGRRAQSEYTGGEALRRVQANTSWDSAYPRLSPRQEISNPQSSSSSNPVPNSSTIGSSPNWSAIVSGTALWMLSPSVVQGVAAAKVCATDDSGNVTCHDTLSAGAIAAIVVTSVLVVLLLIGVAYFIYRSRRRRQEAIKSGNWTFGHHGQHHGHRHHNKYDVFEQPELGYSGWSFSPGNKSSGGNGKSSRDVASASRKIWSAPGTARSINEKQHTGSVVGSGTAVGSGTAPQTGLGTGMMGIGTGKTNPSQPGTGGTGSARSGGPWSAAQLAWRGFRNWSWMTKSAPGDKGNFRVDPYVTYGAGKDHDRSPRSGASSGQSGGKFEEIDIHSTGTGHGHRRQGDEDRYMSVESSQIEGPRGWEGRYEKFHLALGLASAPLAGSGKNAWSGGRGSSLRRTRGRERNVEAGVPTKSTSANGTRHGLSSLSRSGTKSAGGSRSPQPIRDDTRSGGRQRSKSRGERDRDAMPALPPAGSAPINITLSREPSESRSQGGQKGQGRTLTTQASSVSARAVPPQLSSAVAIAQAAVRRAEMSPHVYNGSSSGSGSSSGSPSRKPSQLKHLPNPSSVILSGPGSASLHTIPVPSSPLVASVTATDLNDSSLSVSKLTSQAPSLPPIPPTPAIPPPKFPLTGREGDLEMSGVDSRKVSTREEYEKDMFGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLL4</accession>
    <name>A0A8H5CLL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000147">
        <property type="protein sequence ID" value="KAF5343171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLL4"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="180" mass="19004" checksum="553A28C1EA62C53B" modified="2022-01-19" version="1">MRTRNPLDTADTCTNSLRDWVDGIMASCGQEWEERNEIVVQTRASPSRIVQNRAVKPVREICWGFLGVGWIPPPSQRSPLFKIQLASSMVTDADTDLTLDSDDTSPAVGLKKTYADAVQVVEGVCGEGFVTSGSSTTGTGAVGSYASGARSMSLRVRGARWEIGVGVIGGVVAVVLGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLP1</accession>
    <name>A0A8H5CLP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLP1"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5342967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="68567" checksum="5B9813575B92CFA1" modified="2022-01-19" version="1">MSVGLMQDRQSNGTESISFRAGFIGSLTNIGTLHMYGTDTPVPTTLTLERTPIHPPHKFPHHILSFTLSTPRPRIHIKPPVTPRDYERIPLPLPRYLLHSEYSVSHGRRIRTDPWSLDRHFVCTRRWVWKLISGDVVLSTFSYITVKEDFNTGETVVQIRGPLFLREHVDYSPSSPSPEYELAIQKAHPKPKPATESEQGTSTPTNQPSGSNPVPETPPNNPPEPDNPTPPPALPTIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIRSNGTSERGRKPDAFNGEHSEAKRWLALFNNYLHMNKGKYLTEESQVSLFLSFFTGEKGGDWATQRLIERDADEEDENLASTPGEWRWITLKQIRDRFKKDFKALASEDVARTKIKFARMKGTDISSYNSIFDTYGEESEFGDAALLEFYQDGLPPKLREAVGRTYPKWDDFEEYKERAVELHLEWLKERERQGRWKTTSTSKSSPGPSQGRTVASVNALMGPGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPSRAIRTAETASPPLVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDVMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLU5</accession>
    <name>A0A8H5CLU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_011166</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLU5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5343042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32235" checksum="622F37A9ED271B9E" modified="2022-01-19" version="1">MYNCMCRLARAALPGSFLVEFLPIMKYLPEALAPWKKEGNEWYRKDTAMFQGFLDEVQSKVNPGQAKPAFVAGLLERNSGQLSKAEASWLAGTMFMAGSETTAAALTVFVLAMRLYPNVMKKAQAEIDAVVGRDRLPTFEDRDHLPYIQAIVKEVLRWGPIVPLGVPRRVMKDDFYEGYFIPKGSLVIGNIWAMNHDPTIFLDHDEFRPERFLDETGTVNVTPADTRNQGHVSFGFGRRICVGLNLTNQALFIDIASLLWAASIEPAYDETGAEIVPSAMELLDEGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNP6</accession>
    <name>A0A8H5CNP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNP6"/>
    <dbReference type="OrthoDB" id="3234968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034592181" description="Transmembrane protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5344236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47479" checksum="FE7BA26E9A9040D1" modified="2022-01-19" version="1">MGLPFMKPEVGLAVLFLTCSVWSATTNVTVEETSARIQYIGSNWIKNEQHELFHGGAHDRTQEDGGKAVFTFTGTAIYYYASLWPFNVSTVLTLDNEASQTLNLTDPDQPNAEDGPPTTVSDIRWQRTDLPNGLHTLTVERENYVLVDAFLYTTDDTKDVTGYDDTTSGSLQNVTVQESDPQITYTGDWSKNDASSLYSGGNHALSEDVAASAVFNFTGVAVYYHSSLWPFPVTTVLTFDDGPEEVLDLEDHSVPIIGDGPPTVESVIRWSRANLTDGQHSLTITTGSHALVDAITYTKTPADSSTTTSSNIEAGSPTAAATPSSGSSHSATVGGAVGGTLGGLLTLAALAVILFRRRRRLGDLGIQEFPSPNPAPRDMSSGGLGEEFDPSWIVRPFVMPSSDAATGAGSSHQKKGGHGHTVPVSGQVNAESSRYEPPPPSYRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNQ4</accession>
    <name>A0A8H5CNQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNQ4"/>
    <dbReference type="OrthoDB" id="2751120at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="898"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5345060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="976" mass="110039" checksum="F98F0241D1CE85BD" modified="2022-01-19" version="1">MLFICARCVDLDRGRLRLAGPPSSAGLGLKASGILQFSAFSKHSLMSTDQCAMNKDGTLKDATEIVFYHDVDDVTPISGPSNAAASIRGRNKNARMLASIESDKYEADGVTLSKPGPVRRRKPKKKKTKGQDVDSGLDDEDYSDSGSGTTTDGSSEVEIMDAEGISDEELASILPAKTFLKPSKVKGKEKANPKKPKKSMKRRREHDEGSEAGPAKRTQTKNLRAASVEEVEDEEAPPRPAPPRVNKVPGGNGKRSDAIYLFYEQVPFNASGELGVPGLKKHLNKNFKHLHQFFEILQERRKQGVAWTQDDINVAAGRKPFDDKFAAALEEEIDSHQETIKEAFTKQRAAALEPWNQERFEELLVKWLVASNQPFSEVEQVEFIELLQYVHHSGGKLHIPKKDAIQRRVLKLGEATIEEIRDIFLKINGKVALSIDAWTSSNQHAFLAIVAHYINEEGQLEELLIDFRELLGEHSGENMADAVWKTLELYGLVGKIIAIVMDNATNNDTMMKSLEDRCRRRKVTFSAKASRLRCMPHTIHLAAIKLLEGIGAISSKTGRKLETRSSNYQDNFAIHVPPPKSTNSKSKTGEDKEDDEAVEQDEEEEDSLDELKKDGIIPSVVKLRKIVRHVRSSPQRREAWYREIQHVYAELTAEKSEMKLLMLILDVITRWGSTHQMMLTHNPISTIGRAGAFRDAIDSYASQHSDLLDYCLDENDWNNIIKVTGWLKTFRAATVQMSTTKTPMLSSTLEVLRELEDDIKEIIRSLGTFDVSVHVRDALVAAHSKLSEYFYKFDESPFYTWSMLLDPRIDREALEADYEQELTLAGHLNTSRQKLRDYYTDNYLSSRTSLNMASSVDSIGPSDVVHVDGSPQKKFKSKYHRKVDAVRDELNEFWKLSPEDSTCDPITWWVGHKVTYPHLYRLALDIFCIPGSAVAVERVFSGGRDTISLRRASLSAETIRLLMIAKHRLYLARNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPH1</accession>
    <name>A0A8H5CPH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPH1"/>
    <dbReference type="OrthoDB" id="10067843at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034487158" evidence="1">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="326" mass="32862" checksum="4703153F3375B073" modified="2022-01-19" version="1">MTVRLCASGTLLLVFMSMCTIQRQDGDDSPCAFSEVCLKDDMFQASFSINTSLLSFTPISFVSHITPPATMTSATAPFTGFVGLALSLCFVDAVPLDNSITSVTTSVGRQPSTRTFVVGTPMSSIVSQPANGTIVSSVVGAGTPITSVVGSPVTSVIVDPVSSAMIASGEPVTIPAGSGVNSVTFDPVTSVLSNPVTSIVRKPITTSVVGSPITGVVGTLITSVAGSPVTSVIVEPVSTAVVSGVNSVIFDPVTQAVGEPVTSAVVSSVNSITFEPVTHAVEDPVTSVVGTPITITFTPAVTPITSVISSPGSPVTSSSSLKSTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQI4</accession>
    <name>A0A8H5CQI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQI4"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="40192" checksum="553531F62C04D8C0" modified="2022-01-19" version="1">MKISSSAPTEYHPMSLVSDEQFFQVKNRFSETASGVAVYGAYTILLLITTYTIIAQGLRKSKGRRVLLAIVWFMYIDATIIGMVYISFFRMNIDIMQTTNPNPPTSRDFDRLYKVLICFSNTNYILADGVVVWRAWVLYPQNLKVRGFLVFCMVGSVAASIANGVIAVGEVPHTHEEPEGLGTLGFEFFLPLLGTNLVATSLVAYRVWEYRAMWSQLGKDTKKYSNSIAEKTLIIILESGILFILYLIIAMLSALKILGTLAHELLECILPQLEGIYLTLVILAVTYHQRIASASTSFDEFGAIDIIASSRREIHETDMIFARGQPPHNDDQSSVEAVPMPEAKPQRIRTRDRDGLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRH6</accession>
    <name>A0A8H5CRH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRH6"/>
    <dbReference type="OrthoDB" id="3066004at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="318" mass="35213" checksum="7A7078429B92C066" modified="2022-01-19" version="1">MFKRKRKPVNLGKLAMANHKHDALPPQALHATKLLIYHSRHRLPAPRVDNPEQIIRSQSGSRTSLGGAVPDHKNPDPNPDPEPHPNLPPNPSEPDNIIDSDSNSDDDMSKATKAFDKRAAGSIGYDTYLTTAPTSAAEEQQQDKDLLNSIISTLPDTIFRRYKNKPTSKELWDVLKQDYDTKDPLTEASLEKRLFSLTCTNPAKVGKHLDNLIAIMDELAERGVSIPDSQFKLAIISSTPNMYQATVKALITVYREEPSKLTPEMLIAAICAEAQGKNFTSSSNKSQESVNYSNNNFRGRGRGRFRGRGRGRGNSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTS3</accession>
    <name>A0A8H5CTS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTS3"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5346928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="241" mass="26772" checksum="685A41D8CE9CA5DB" modified="2022-01-19" version="1">MASSGASKTKRNIEKKIEAKRDPITKWITRIAVLVLFIVTCRWLDTIKDRWYVFEPTKLHQLAQAAIAANPGNGPAMVEHIVANLTAEYPSSVIAINPNTSEWVFNNAGGAMGAMYIIHASITEYLIIFGTPLGTEGHSGLHTADDYFNILVGEQWAFAPGSFETEVYPAGSVHHLPRGMTKQYKMHKGCFALEYARGWIPLMLPFGFADGLTSTLDFPTLYNTAWRTGREIIRNLLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU13</accession>
    <name>A0A8H5CU13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="607"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5347063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1433" mass="157361" checksum="9475415182D3047A" modified="2022-01-19" version="1">MAGSRSNVTSKFRVHHANVEDVLHYVRMVSSLSTGQGTRFVLAATEHLHRRIGRLSARVRQLEDALSSLHAQHSDNPHPLLDARANNFDDDDEKDFEKSGDQRAIGMGEGSSDMGISAGMDRDRDRSRLDGIGGDEYDRTRKTRVGGRDVIDAFGTLSISDHGISRFFGPTGGSESLLIAHGNRRKQEDEEERDKDRQDNERSRSRSANRSLRASASPRSMEGKDREDEGHTSSSLSPTTSHQTTSSSIASVGTGATSLFSATGRHALVRSQGQTGTQSPILFSSTFPFTPLGLPTAQIMNLIQEYLPERRRAEELLDVYYGQLAWLFRGVGREQAEEMIWAIYGALGKGVGRAGERGWESEDDEKNPMRKDRGRSRHWGGEAKDGANRFDGPLESNYQGPHDLSLLFMLFAASALVETEPKETDADERERHGQSDAQMQWGQTHAGNNMIIMIGDEEDGAGVGNASRSHSGSAPTSPPYMHGQPAAVASTHSVKSSAARATALADHYHQLAQAALSLQPVLEKPSIVTIQVLHLMSIYNAMAGNEVRRDDGEDGDDVDDERGGRSRSRKGRGKSKSVGREKSRGRDGKSRRRRKDDDIKEASMEMTWSLLTMAAHLSQTVGHLGSHLLSHFANVFNQIGLHRDSERWGLSPKMVQRRRVLFWDVFVADAWQSLNTGRPPAFSLAYIDCAFPVYEGVNEKDGKTGEEGQQASTGNTGDKTGAAFGVWQFRFAAECVAEVTARTLTAEAPTYATIMDLDRKVREFPLPEGFGPSSTSSSGLNVNGSPSQAKEEDLAMSFRRCVLDHIRETVLMYIHRAFFAQAIIEHPTNPLKSHYAPSFLAAYRASGTILKSIREQFAIWPIASARFWTMWTFAFTAAVVFGTVVARGPRSPLAQSAMAELEQACILFSRVAIYSKRATKSLPILTNLREKARLALSGGSYVPSPMTDLSLSHSALSRLSTNTSPLSGINGELLNLQKDDMEDELSIFAGHTRFVSSRPRSQNALPPVPGDSASTSRGMPSAGMSNDIVMGINGRSPYGAPGGHHMSGDGVMGALPGMETMPGQDARGPYQTQIRHASRVRGPYDVEVDMDINMDLENSPMRYPPTVQSMEGYAQHGYQPHSSQPPSAPSMQLFDDSHYSLPPPPRTTEPPYHSLHDQSNRPHMMSPNALDDPEHSAWIRPPPSREDTIRPGADYPPRNYPPGYYREDSRQSRDYLPREDYRRDYSQSREDHALHSQAPSNPPPIAIPPIISIPPAPMSASHDRTSSPSHPVRYSYSYDRSSRPNLPSGPSPEVNISAGRRRTASRPSVPSSLQSSSPVRLTHPQYGPPSAGSGPPPRQMDMDTDPYYSRASRAPPSHHEHHHQQYTYPPPNAAHNIHVPSHHSAGGQGVPGNPALADLGLAARDSRLDERWSSFMADSGILDDVSYGNNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXS4</accession>
    <name>A0A8H5CXS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5348998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXS4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="15029" checksum="0BAA857BBAA0BDC9" modified="2022-01-19" version="1">MKTSTEIVQKTILRIDDPELSGFFKFLTLPSLSNLTISGVKDDGEGMCHLTSLSLENLPLQDMEVIALLQVLPCLTALHISERHLEVDEGSDQESFRSPFTGFFSDFLTVNYRKPSSSTLLSRLKEQRARPALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZC8</accession>
    <name>A0A8H5CZC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZC8"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="745"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="93876" checksum="9FE5FCC32A2B3418" modified="2022-01-19" version="1">MSEAAPAKPSTPQAVSKIFHADSGGDIVFRSSDNVLFYVHHKNLDFMSEGFPPVNHTIPPKEPVALSKDSKTLELLFQYTYPSRMPPDLDDLDFNGLMKLAEAAEKYVINHARGPCVKQMSVKFVPEKPFTIFVFACNYDHENLMYQIAPRLVDRPLSAFLYRIPPGIYHPWSLYRDQLQLPLPKQVALQHFSDEKLRVAVCEQRANIPPSQAGFNFHNPSVFANYGTHNLYWSNVKNNWKRKIIDQELSCRGIEGLVDLSSVPDEYKKECCGPILQWREQLLALSRKPQRDLREYVKEYRVQKAKIQIAFQLQEYISLLIRLDVHDVDAIISIPGTAKSSTEKVSESASGSDGPESGSSTEEKEKSTDSKKNEVTVDEPCWIYEQLRRLAQDLSHPLITTLQQECNRSTCPEMKAGEWLYLCVAHGNDGAMEQCCAIDYILHTIDSATALLNSPRAFPSRLQIPPTSHRHFSSLARRLGRIFAHAYFHHREAFEQAEAESSLYARFLALTSKFDLVPAEFLVIPPRHDDRDGDVEREVQPPKLLAAGLNPMESSGSQEPRQAQTSGTSDPGSTSAVRDDWPRNLQVERSKSNSPSRTGQDSPRRVGRSRTDTMVHSDASSVVEELAKAEEEHHPVPPVPKSSSESTTSQAPPQATTTHTQETAPSEQPAPAATSTKEEDAPALLPANDSDIIEEPVREPSTSSASTTALEEELATPATTLEETPESAAEDTPAVATESVETEQPSESSPSESVEESAAPAEEPAHAAEVPASHPEPDSEAGEKTEAETTEASESVTEDKPVEESAPASTVVEEPEPTAHAEAPTAEETSEDATTEKKEEGEFLVTTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3H7</accession>
    <name>A0A8H5D3H7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3H7"/>
    <dbReference type="OrthoDB" id="3178264at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034347411" evidence="2">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="34408" checksum="F9804BA49B620AAF" modified="2022-01-19" version="1">MIFLRPALIAALVCTSIFGAAAVPLQARQTDNLQCSAARLKAVTGLTATKKAMDKMSPLAAQDAAAAAASPISDANTSLQSAQDGLDTIGKALSAGQAIAAEAGTKVSDGFQAVKAALDSIKATNSSSPFGDALRQVITQIEDAIKAGTEVETSCGGESSTASSATSTSASTKNTASASTSANGSASISTSASASISASATVQASATDKSANSASDTTSVKAMATGSRSGSGSGSNTVTVTETVTVTSKGASQATSSSAASASQANSSKASGATSSASASQAASASASDATSAASGSHGLQATSSSASGAASSASASQTTSESAPSATSAASGHAAKRRGVHKISDATRRLGLGLIDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D530</accession>
    <name>A0A8H5D530_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_010594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D530"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5353837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="38842" checksum="D51E922C4AD5AB33" modified="2022-01-19" version="1">MSNTPVEYVRLGKSGLRVSVPIVGAMSIGSPNWAEWVLDEDKSIQVLKAAWDRGINTFDTANVYSNGESEKIIAKFIEKYQIPRNEILILSKCNGLVHKDISVRTVNFPELKNTREYVNQSGLSRAAIFNAVEASLKRLNTPYIDLLQIHRFDVNTEPEETMKALHDLVQSGKVRYIGASSMRCWQFGLLNEVAEKNGWTKFVSMQSEYSLLYREEEREMNAYCNYHGIGLIPWAPVAAGLLTHPVDEKTTRSESSKGQRYYPDATETDKVIIKRVQEVAEKHGKSMAQIASAWVNAKVTSPIVGMSSEKRVEDAVGINGLKLTEDEMKYLEEPYQPRPVRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D582</accession>
    <name>A0A8H5D582_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D582"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="388"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="678"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5352951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="108124" checksum="2D3B912B7C2E5C2C" modified="2022-01-19" version="1">MTLPDSLRRAAAAGPVFLALTVENLCRSLQQLSLPDLHYIHSRIDYTVPNKQGKRLRALSIAKFVVENLAVTESSLLPAPAVHDYHAKCMFLDRRLGEGFCRMFGEKMLYTIIRSGIYDYDGPQRWLITHQATDFIKNSFESQDDLSRLVISIPVNMRVKYDDTEYHIQTQDFRGQSNSLSTILSRFFTARLKILFSLSDDDLAQVFLFYFPGTQRNSFDFEDRDTAVLKILTGIFGPITDILFDHATYDDSSDMQALRVPTFDQPDLYRLDYLQERQRWPEFVPLSTILHCLSTYRQKSVYVYPRTCGCCACDDSDYSGADVPVSQIPSLTLLKCRDPFILAHVSPERFQYVDRSLNGTLLEKKSIVQTDKGFTIYLCKDCHSSLLKSKLPALSLVNCFYRGELPADLLALDITWAEEMVCALYHTTVLVIRLYGSVDEDQPRVLHGNASAFELNTVSTANVLPWTPNDLNGTISVVFVGPKKMTLPELRQIKQLYVRRSVVWKLLNFFFLHNRLYMNLPPPSAEILNMYPENDILPGLQERVIYDLKSDAASNFDQESSSFSEHPSAQFMKPATAESETEPFSESRQAILERHGVHDPECTKIPARSMISSALANIRTDRDRSIPDLAIHHSYSFVSEHNNPDLICGMFPTLFPLGVGGFENRDRKPYVAFDKQANYYLDYHDRSFRYHYTFLFVVFNIMQRRIAHLHVHMTTTSQSLFSVANTFASLSSQSLEKLAKRIEKEGYLQTMSPEEKLGFQLLRKVNTVAARIPGSQSAKVHTRNEIRSYFGYFGLPQLFFTFNPCAVHSPIFQVIFGDRSVNLDQMYPKLVSRYERACRIARDPVAGADFFQFSFQTAFRYLLGWDFDKRCSTEEGGIFGKIRAFYGTLEHTERGEFHGHFEIFLVGGLNPTETHAKMRIDPTFERRFCDFFRSAHLASLTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8R5</accession>
    <name>A0A8H5D8R5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8R5"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="6">
        <location>
            <begin position="166"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="5">
        <location>
            <begin position="373"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5355323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="476" mass="53506" checksum="6D35C8B4B32C7E18" modified="2022-01-19" version="1">MSTSRLSLAQQIAQLDTPAPAEVDTEGFFPNIQYAKDGNLGREHYLDVGPSKLRNDSLSDPKYDGVKISRKQLMESDDMGSESVEEDEVGEDESGNEEKFAEVGNDIDDAEIPSDNAEDDENGDEDVQSEEEESEEDVEEDVEEQHSSRKEADEMTSALRRKQDDDKQKGIAVSRQLTTWDSLLDARIRLQKSISSANALPSTLDFADSPEYQQSLSKMLAEAALLSEELINLQETLLNVNETIDIPPRKKRRLEAESKVSDYEAYLKEASQVRSSIDHAYHPHLVQTLSKWSSKIQAVAPSVLLPSNRNAFSKDRSALKSAVQLVDETLEGHDKLLSRTRIWRGANSRLRAPSAEDDENKEDVEIFDDTDFYQQLLRDVIDAKEASGGDDWMVIQKQKKAKKKVDTKASKGRKLRYEVHEKLQHFMAPVAVRGAWHEEQIDELFASLLGKGFEHAAVEDITENGVSEMLGGFRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F1B8</accession>
    <name>A0A8H5F1B8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000414">
        <property type="protein sequence ID" value="KAF5320215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F1B8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="143"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="670"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="811"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5320215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="976" mass="106742" checksum="7E3BD67561E2B32A" modified="2022-01-19" version="1">MKRGIDNVTEQNKREKLVLADPDTGPVGRATENETYLDGQIPQGPRISAGRDVHMNNVQGNHNQTINNDYRQTVNSNNINNIQTGGNNTFVMVDMNAMDNIKKWINAPDSSFNFNAAYDKMTKGTGEWLLKDSRLIQWKESGGLLWLQGKAGSGKTFLLTKAITSLKADNHDVLYFYFDTRDQSKAKATYKGMLASLMLDMGLQFNQAQLMNLYEKYNSGRTQMPADAMKSTLLDFLRQKSSSMFIFVDAFDECDNQEQHPVTEFIQQLLVPGLKIHICVSCRYPANHIGMKAGTYEISLNPEVVEGDIEIHIQQSLQSKPLFVNIKEEVTEALLHGSHGQIRWVDCQIQYFHQLGSGRAIRKALKSLPKTLEETYEQALSAIKREHKDDAQAILKWLLFGYEELTMKMLVEILRIDFEQQSLDDPEPIQGHELYNIISSTLVVVQQGTYWRGRQEDILQLGHPSVKEYIVSEEIKESSAKLFQINDQLAHEFIAQCCLIYLVVCGKDGHIDRALFPLAGYAVNRWTEHVRDLQQLGDPVKCLSLHLLTDTNISCLTWMDLTPYFWGAGAGSALPFYYASMVNLPNMISSMMENGEDVNAQGGQHGTALQAASWEGNVDIVKLLLENGADVNTQGGKYGNALLAALGAGNKAVANLLLENGADVNAQCGEYGNALQAASCGGEVDIVKLLLENGADVNAQGGEYGNAFQAASYGNQFDIVKLLLENGADVNAQGGEYGNALQAASWQGNVDIVKLLLENGADVNAQGGLYGNALQAASYGGEVDIVKLLLENGADVNAQGDVNAQGGVYGNALQAASYIGEVDIVKLLLENGADVNAQGGGYVNALQGASYGGEVDIVKFLLEKGADVNIEGGKYGTALQAASISAFDSDYDYVRLVEVLLDNGADINSQGGKYGSALQAAAIKGKEKIFDLLIQRGATPIDPLFTIFQNDPFHLWTMNQQTIRSTIHSSGICSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F4U8</accession>
    <name>A0A8H5F4U8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000392">
        <property type="protein sequence ID" value="KAF5323652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F4U8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="272" mass="29923" checksum="2E5DF6A3A9D3FB8E" modified="2022-01-19" version="1">MECEDEDEELRFEVMNGVDHVYLADSFELTTQCRIYYTDYAFIDDPGPNNDCAGAISAFLTDAQSSPSPLISVANSTYMRALRRGLLGYRMVFEVWGDARFYHHPETIAHLFFQTDLLRYLQPLPLKPGPVLGTLSALVSSLVHSMPLGGSRLRRDDGIQGNVVQMTYTLLRDKRGCRMIYPPLQNKGQTPKSLLLILEIRFLPTHSRLVGQGFTTEPFPGNLLLMPRPVFTDADGESGGDGEGRVDDEGEKGGGDDEADDIGKADADGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FB50</accession>
    <name>A0A8H5FB50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_018257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAACJM010000341">
        <property type="protein sequence ID" value="KAF5329908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FB50"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="76"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="344"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="344"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5329908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="469" mass="49017" checksum="E69AC63E36A03EDE" modified="2022-01-19" version="1">MNYKISLPSPFLPSNKRVVHPLFAGLLGIHCTYSFICLAASRNFKNISNKSQMLSAVSVSLALGLLAHLLPVVEAHGQIGGVMANGKYNAGPNIYYDGDSVNSQTAIRKMFSAASPAYLNYWDFNDNSKMACEGAGPAPKTIKVSAGSQLQIYWEGATGELLNKPGTGNTKGKNPFPHAMGPVTDYIASCNGECSKFDAANADWVKLAEFGLDKSQSVSSELRNAMDGKPEPYYPKEQGLWGIAKLVQESSTWTVTIPQGLKNGQYLIRNELSAVHSPKSSGGGPQLYVGCVQVEVVDGGSEGLPGGTKAGSLYETDGYLANFNVYSSNVFKDIGPTIANLVSGGSSSSSNNNDKPSSNSGSSSGAASSGSSSGSSSSSSNTSQNSGSTDAANSFTGDSNSGSNSSSSKPDSGSKDQSSNEKPSAPSSAASPASTQRCKARKRSLPGSQVHKKRALGGHREMMKKRMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FES4</accession>
    <name>A0A8H5FES4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FES4"/>
    <dbReference type="OrthoDB" id="3057775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="30926" checksum="FF8D3DDF9D79D76B" modified="2022-01-19" version="1">MGFGFGTPQRVEVDSGVHMENRQLNHRSNRLARLLLFQYYRRHQRDTRLPPELTGSSDYGGGVSGKGVRWEVGRGQQTSQTPRHPIWRSNRPLCSSGSIHGGLAIFLAKPTSNACSGLQRLKIGQIAFIDQPHLTTIPTSPRMVTSLVNPTKHSFPAPSDNLLKGGRPSTAYYGILDSSPASNWNQPLFVPSVKKCTPPDSPNFRNLRSTLVDGLARGTVNNSPFPFSLHNAVPQPPPDYEPFNFSLAHTMTFICHQGASFPHRADPCITSTHGHSLMKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFS8</accession>
    <name>A0A8H5FFS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000251">
        <property type="protein sequence ID" value="KAF5334828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFS8"/>
    <dbReference type="OrthoDB" id="3259206at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="134" mass="15103" checksum="9F4397E9DA389F80" modified="2022-01-19" version="1">MSSGTLEGQQPSLPIVSSDIEVLKIWLLQTAVSWLLCGINVPLVFIIIFIILSQRKRHLNAQLILFAFVVLMFLFTIGHVVVNTQFILVQLPNFSYTGPNVVKSDQQEMIFEIATAIFDRLNFVIGDGIVIWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFU1</accession>
    <name>A0A8H5FFU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000246">
        <property type="protein sequence ID" value="KAF5335234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFU1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="290" mass="28679" checksum="7DDB4920BBFFF143" modified="2022-01-19" version="1">MYLLPSQTQSQNVNEDRSRDTSVSASVEGSREGSVVVVGGANGGDGGGEGQGPVSLSFGVGAALESDADVDARPESESESKLKLKPVPTNEFASTSGALGNGLGRIGNGSGNGNGSGSGAAVAESSTKPKPLHSGAGADNTTGTRSPTGGGPIIDGPPHKDSLGAPTYPAHHRQKSSALSGVSDASEALSIDDEMLVMPIGPGSFSFTRHGHKYSQSTSLVPLTPNSPSFAGMQSGTETSGGAGVSGWGSAIAGGSTFRPSKHRTTLSSGSTTSRGSSARSPTVSNLIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKG3</accession>
    <name>A0A8H5FKG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKG3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="59" mass="5812" checksum="43D42ED3D5E872FC" modified="2022-01-19" version="1">MGLFPPQPHPSLASPSPACKASLGTEGFELVEEILNTVSPVCVGVGGYGIGTGGSGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FL78</accession>
    <name>A0A8H5FL78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosine-purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_016176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000167">
        <property type="protein sequence ID" value="KAF5341320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FL78"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5341320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59538" checksum="D83484CDF349F463" modified="2022-01-19" version="1">MTQNYSSLLRAFFPSSSSVSSCPIMAQTDLERNLDPSEVILEKDEFAEDEARSSSKLSSRWKRVTGKLLTWGVETRGIQPVPFEERTDEQFFKIFFLWFTTNFGILSFSAGTLGPAVYSLSKGDSCLVILFFNLLCCTPVAYFVTWGPKLGMRQMIQARYSFGYYGVIIPSILNLIGGFGFCILGCIVGGQTLASVTDGRMSWTVGIVIITAIALFLTFCGYNVLNWRVPYDRLGWIPVLVCFLVALGLGGKHLSTPAPAESATAASVLSFGSVIAGFVIAWAPMASDFTSYYRPDVASWKMALYSYTGLMLSNAGLQILGAAVASVAPLIPSWNDGWNLGGASNVGGLLQAMLSPVGNFGKFLTVLLSLSVTANIATTMYSMCLNFQILIPKLVVVPRYVFSLVATAIVLPLAIVGSHRFYDTLENFLALVAYWVSEFVAIVLVEHFVYRRRNQTPDLDISYSTTMGYNITQWNRPSQLPTGIPALAALVLPYGLITPSMNQVLFVGPIGEKTGDIGFEVAFFLCGLLYLILRGLEVKWRGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMP1</accession>
    <name>A0A8H5FMP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMP1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17942" checksum="A9482155EE601B38" modified="2022-01-19" version="1">MFSNSRPSLTQSSQDSTYFFAVGRLLRTRPVVKRSTPSTSRDLMLRTPPQMHRPLHKCHPYKRTRYTSHVNSKPYQISQEDINKFAEAVRPPSTSTLASAKYPQITLLARKDEQNRDILEPQPWYVMIFDFFVALPVKVRECRAVQFVSPAANNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FN26</accession>
    <name>A0A8H5FN26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FN26"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="706" mass="80800" checksum="28984F73A727F5A5" modified="2022-01-19" version="1">MAGRQLLFPFHNSRLLSLMRLLNTNTLKLAEFYADIPRYAILSHTWEKEEVTFQDIQNLETASLKAGFVKVWNACARARNYDFEWIWIDSCCINKESSAELSEAINSMHQYYEDAAVCYVYLYDVSIEFHPRNPKSTFKDSRWFKRGWTLQELLAPRNVVFLDKDWVRIGTRWTLRDVVSAITSIPVEVFEGRDINTYSVAQRMSWAASRETTRAEDQAYSLMGMFGVSMPPIYGEGGVKAFMWLQQEIIKISDDRSIFAWVTASSEHDENRGLLAKSPYEFRMSGEVKASESDRIGDRSSYSFGNNGLRIHLPLESAGDDDVFLASLLCQSEKDGSFLSFYLRKTSPHQYARCYPDQLVFRPTLQPALKNIQELTVRENRVTRMSRFENRPWYDSAGMYHVDLLPSARHFHFTDTISFPVVYSPDPNRVSVQLEPWPSLSELTYKTQVTEEAFTIHLWHIDFSYYALHLGDQPFAEPSFFTDPSLDDGTVVRSDSGAISVHCEMTGRLGNQRLEIDFIDQDSLEIDFWTQTLQPPCSGFIVPYKVDSEGLDGGRMRLIGVYPSDFYMKTFQDMAYIPMSPPDDGDTAPPFRILAYGIPGKSSSHVAIGLLGPSYETFWTEFAVGRGTAEQVYQSYINRSRAGKEWLKEETFIWSDSLYGGRLTASVQERSSLQLGTHHLEWISNSISLRRRLAGGMKRGKKETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPL8</accession>
    <name>A0A8H5FPL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPL8"/>
    <dbReference type="OrthoDB" id="2992074at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034136629" evidence="2">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="232" mass="25096" checksum="237F4ED738686EEC" modified="2022-01-19" version="1">MFFAFCVLWSFCSGMDGLMRLREACLLRFTHTSYWYNAALPAELCLITSQSTQAQALSFKERLTKSRLQAQDGFDLPPATETDPESRPLTGVQSAKVALYSLVLTFGIFLEVVGPLEAVVSSDGTGRPAPLGPLTKARVHFYSFICMAMVWAAFGIMFASQTPDECNPRNTGDFADSGCGTLAANIALSFIECLLSLATAALLWTKTTGPSSHVGDDRGTVAWHEMAKQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPX1</accession>
    <name>A0A8H5FPX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPX1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="296" mass="33038" checksum="B9BF87A4AC454E18" modified="2022-01-19" version="1">MKTGIARLQKILEERIDLSPKSSRAFADPPLALVFEIILKEETSEALCGYTFEAFANQEQTFSVKSLSTSSRPLNLVVIVHDDDKTCFDDEESSLLSLNNDHIHISFATLQDNEIVFSVFQIPSESSQSSTAALPSSLPNPPRPLQRSNSSPTSSPKRPLSSPVLRAKTRLFIDAISTEFVPAFYKFQVLGDSSPQSIGSMFEAEFSNANGAIAPFLVRWDVGLSEDIGAYGEGEGEKVWDLLSKDAKYERFRRYLKILEERESVKKTSDTDYIRDFYGRRFAEARAKRKAQAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT33</accession>
    <name>A0A8H5FT33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLA1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT33"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLA1 homology" evidence="2">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="SLA1 homology" evidence="2">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SLA1 homology" evidence="2">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="322" mass="36285" checksum="5DBAF60D306C2637" modified="2022-01-19" version="1">MRRETCRLERPNLEVVEDDRVTSESSSQLSPNGAPPQNLIRRWHDITGQFKVDAALLAYKDGNLRLQKTNSVIIQVPEDMTYVKRSMDSEAIEEDDCISQSSSQVGPNGPRHPTVTVTWVTNLNIRQFRTVTVTINPHSLSTAPPKNRVRTWHDITGQFEFDAALLVYNGGNLWLHKTNGIIIQLPAEKLLGEDRKYVARLIVKMRRSNRLFQLQKLKTLKGDHRPISTVSSHMDSSSGTPPLASSRVVPAGTPPKNHIRTWCDRTGQFKVNATLLAYKDGKLRMHKTNGVIIEVPTEKMSVDDMKYVQSLMDGKKPAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FT65</accession>
    <name>A0A8H5FT65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FT65"/>
    <dbReference type="OrthoDB" id="3063885at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="513" mass="56957" checksum="DEB8E0B0C2E7B18A" modified="2022-01-19" version="1">MQTRLEADEIDYEDGTEELEKGIYEAVKEAQDALENLEINGGDDDGDDAPLEPAPTRRDALQAVASNTPQIATNPFTKSHKKGKGKSEHSDPSLELVKGKKSVVRVITIDEAPEVWPIPHSDTPIAYILDLNGKPECLSNGDRMLTVDGFIKKECQDAWGGDTGTGKFHCFVGHRGVQNLKTYISEEDFKYLKSFPDLDSDLKIAQYASYCDAHPHEKVQAWWRHKESYPWLLSSLNRHLSLMDPSHWDIVPANTNMIEGSHAQDNQVTGIQHTLPRCKQFDDDTARTVLASKASSVLSKSNNTVLDHFKAREVVKRLNASARNYRSWREILLQSSRPVEIGQNNCSSRSKVLRRHESAHQKSLPAQLLLLVDLLHFVALQFMVVSVATPSSGKSSLGGTGTPMDPVLIDFDIPAPRHSADTPSLYSPLRFSVPGTSNYMQTPLRKVWNRATQLSKNADNWDWETINAALAECDGPAPAPNSYYFATSPSGEPRLYPVEGNEDILASFPAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVH0</accession>
    <name>A0A8H5FVH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_007796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVH0"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="304"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5350217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="604" mass="68790" checksum="06B95DEB2717B61A" modified="2022-01-19" version="1">MKITQKISQCDKDNRVWWSFEYFPPRTAQGLQNLLDRIERMRGLGPEFIDITWNAGGRTSDLTAEMVKTCQGLIGIETCMHLTCTNMPKEKVDIALREAKISGCRNVLALRGDPPMGKEEWEAVEGGFVHGVDLVRHIRREYGDYFDIAVAGFPQHMLLPPEERDREMKWLKEKIDAGVNFIFTQMFYDVEIFIDWVKAVRAVGITIPIVPGIAPVQTWNGFQRATSLANIAIPQIFMEALEPHKNNDEKVREIGTKLVADMCRRILKEDLGIKGLHFYTMNLEKATKMLLEELNLVPRVETLKPLPWRQSLTPTRRTETIRPIFWANRTKSYLSRTENWDEYPNGRFGDSRSPAYGDLDGYGVRIKQTKEEALKLWGEPTSVSEVTELFAQFCLGKLSALPWSDQAPASETFVISEKLARMNRLGFITINSQPAVDGARSNDEKFGWGPSNGYVYQKAYLEFFVNPALLSLLLAQIERDSQITYYVINKQGDLRTNTHSDGPNAVTWGVFPGKEIVQPTIVEAVSFMAWKDEAYELGQQWAKVYDSDSTSRKVISDLMNTCYLVNVVHNDFRDPDAIFRPFFKAGEEYLASLKTTPAVTVNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVQ6</accession>
    <name>A0A8H5FVQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVQ6"/>
    <dbReference type="OrthoDB" id="2837203at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="606" mass="68129" checksum="CFF6CD3CFFD9989D" modified="2022-01-19" version="1">MAPETRSGIFRLPEKRGGTVIQVKLRQEPAWRLRELLRGNGLEVGGRWQELFDRLQAFSRNEASWVRDPLVTRTSLRTRRESDTGRKTQNTGNAQPMRKSRKTSSKVSSTSTPKSLGGHLHPRLTLTDLPVELITLVLEESEKDDVLSLAVVCRGLNAIAGFFFLKSIGLQAIPHGWLTFGAYVGHPFGVIPGLCIVLNCLANVSSLTFCFSTSDYSKELYRALSILKRLTSCNYLSFHLPNYAYPSPSLASSVSTVLEEFLSELASKNVRTLQIEADFHTVPKRSSKALLPAISIERAIVNTPFIHNSPFRDWFISSFNASPIQSLRINYGAHFSSFLIRLSLPSLREFDVTSCGQIATNFDPFRSFLLRHPTLVSLHLGCCKYIATKGTISPLPQGSLPVLQSLTVHPSILPYFFSIPYSSSREGLSSRRGRRVADRDNPISSQFPPHLRHISLLNMTESCYSTYGVTMDASLEVCKTALFSVSACSAITVITISFDDLLNSEHLRAIGRSQSLTLPFIQSASFRFRERAPLDQVKAILIPWFQRTFPNAELFIIKLAIMHWWEQEEKSDFVRKVRDFCPQVKSVGINFQQYKIEDWLAQAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1F4</accession>
    <name>A0A8H5G1F4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1F4"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5356549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="546" mass="61713" checksum="E51224905A80CCE9" modified="2022-01-19" version="1">MHPALSISELLQGIFRLASPSGKGRMQALLNYALVCHAWKPDALELLMAVLEDVVVDIRMIARALGAMMKGGVVEERLIFPSPPGPDTWRRFQGTFSLRVRSIVVDLKTENDSRLLEVMAKTRPHSFDSFFPNLRRMTVIDDERLLLSDCRDAILMLMNRSVESLSLKSKPEVEQDEDPPSDLPLFFEDFAAIGDRMPHLTSLLISGAYTIDLDIGDEIAILCSRLPSLTELELPSLNDYTRVIESVARHCPQLQGLTCFETELIAAQSVLPMPSLKRLNLGLEYLSELVRFMNQHPVPALETCLFFFDPIYTEPQDLRNLFTLLSSLPHITKIEYSMRGFGEDFELNFGELRPVLQCRNIRELHCGHSRISLTDADLVILGRSLPCLESLMLSPFLHDLEEPEDMPTLRGLIDLTEHATKLRYLQLRLLPIYPPTDSMDNDATTESNKDELTLDSIKSFHCLEQLCVCRSLLDPDWTLVTTLVLGRILPLKCRFRYCALLDHDGPWGVDREEGEVMLSIAEWEKVSFGLKFRAAASCGKVALPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Q8</accession>
    <name>A0A8H5G7Q8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_013970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Q8"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034053598" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5359937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="289" mass="31591" checksum="C75DC44C28DEFC12" modified="2022-01-19" version="1">MLKLLALVSLLPAGSMMVSAHTVYARQYDTAPTTDAGGDDHAFQAPGPSDARGPCPGLNTLANHGYLPRDGKNITIPIVLQAVLDGFNVGPDVVTLAAKGALMAAETPDFFNLTEIALHETFEHDISLSREDFNVDPNNDNIHFNETVFTTLANSNPGVDYYNATSAGRVQKERQDIQNGVNAQLINNVKDFKIRTRESGLYLAVMGNVTAGVATKAPKNFVQILFREERLPIAEGWKKNDMLITVDVLDPIEVEIERFSEWQPSGVQPNPWIRLGPEGVIDPLTANRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G8G2</accession>
    <name>A0A8H5G8G2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_009167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="202"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="584"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="875"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5360297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1453" mass="160783" checksum="A25B3923E03AA78F" modified="2022-01-19" version="1">MQLPFKDDGFPRMPGDELNYGGVGPSAYSLDAVDSTSTDSSPRMKFSNPFHPPPAPPAFGNGKVLPEYNASFLSRLVFQWIGPFLDVGYSRPLEKDDLWELPDDRQTAQLTDMLETNFFTRCPPEQRPWHLREKLRRPNESIEDTSLTSVDEKDNVVPKETELPDETTDEKSGKRAKQKKPKSPYDSSLPKALFVTFRTRWLLSGALKLCADTLKTTTPLVNKVLLTWLTESYIYSRLTDEQRASGILSRPQGIGYGIGIGVAIFAMQEVASLMTNHYMQITLTNGLAIRTALIGNIFRKSLRLSGRSKAEHSVGKITTMISTDATRLDSFSANVHNVWIAPIQIIIGIALLISQLGYSALVGLGVIILGLPIQIFLVRVLLNARRKGVKITDSRVRLTTEVLQGVRLIKAYAWEDFYTMQISNIRTRELNTIKRIIVARSIAIGLVTFIPVLAAVLSFITYSLTGHNLNVAVIFTSLQFLNIIRAPMIMLPLVLSSMSDALVALGRIKSFLAAEELEEPYKVDYDQKVALNVDGDFTWETARKIEESKFSRGAGAGKGGKGGHSGKAAGRGGRGSTSNATLPVSRPNTAETLPKKEEKPFELKGLNLSVPRGSFVAIVGRVGSGKSSILQALIGEMRKTKGEVVFGGSVAYVPQTPWIRNASLKSNVLFGQDEKEDRFNQVIRACSLERDLEILPQREFTEIGEKGINLSGGQKARVSLARAAYSDSETILLDDPLSAVDSYVGKEILDNCLLSGPLADRTRILVTHALHVLDKTDYIYVVEGGEIKERGTFQELMEHSRLFSRLMEEYGSLEQEKEKEMEEGKPGEFKVSGDKEKEKKAAALMQEEERNTGAVSWSTYKKYLQYAGGVAWGPLILFILTLAQVSQVGNTLFLGFWTGMTIPGFRQGQYMAVYAGLGVSQAFFTSLLVFSIAHINLNGSFKLFRTAFNRVLRSPVSFFDTTPMGRIQSRLSKDQDTLDTILSMTLGQLLSQISSVLGTIGLVFYVFPYLGIIFVPLSLGYFLVQAYYRRTSIETKRLDSLMRSALYSSYSETLTGLSTIRAYQEQTRAVNDAQNGLDMENRAYYMTISIQRWLSIRLDLFGNILIFGIALFAAGFRTSANPSNIGVVLTYTLSITQLFSDMVSMIAQNEQNLNAVERILVYSELPSEGEATTSNDPPPAWPANGEVRFSNAQLTYRPGLPLVLKDVSFHINAGEKVGVVGRTGAGKSSLVQALLRMAELQEGKIEIDGVNTRNIGLDTLRSRLALVPQDSVLFLGTLRENLDPTGMRTDAELISLLQRAWLLPKEGSVDPVIEAKFSLDSTVGDEGSNYSAGEKQLLALCRALVKNSRIIILDEATSSVDVETDAKIQSTIQTEFAESTLICIAHRLNTIAYYDRIIVMDAGRVAEFDTVLNLYDKEDSIFRSLCNEANLQRSDILRIRASHGEIVKNTEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD03</accession>
    <name>A0A8H5GD03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD03"/>
    <dbReference type="OrthoDB" id="3041043at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="118" mass="14075" checksum="21BDBDE1CD9E1AAF" modified="2022-01-19" version="1">MLSFPRELQNLVLREFSPVERHRFSLVNKKARELVLQHNQQTFRIRRVLLRFLDTLYNVARFRILQYELGLLVSGSTALQFFSDVVYPDSDLDTYVELVKFRPYADFLLEIGYVFDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDA0</accession>
    <name>A0A8H5GDA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDA0"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="40308" checksum="7ACFD602692D456E" modified="2022-01-19" version="1">MVGYDGRKVYVVKKWETNDIYRTSDVVFEKSGGHWTSELEGENDDMLFLAPTPKSGSSITDQIPDSTLLNPSSPVTTTNENHQHVPNAPEKRKFIESKEYESREKEANEMGEDWTRDEEEDRELLPEFDEEDSPTALKASLKTVLEPDNTWVPQSYAEAMKRPDLWTKPMEKELAKLDSRKAFTPVSKPTDAKIITTRWVYALRLDGNGKITERRARLVVRRYDQVKGIHYDDTWAIVARYESERFAIAIAAHEGMDLWSGDFTGAYLNARPQGVNYLALPEGFQERYSLRDGNETVLLMNINIYGSMDAGNNWYKLLDQRYRELGFKSNPADPCSLRRERMGRRCERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDL2</accession>
    <name>A0A8H5GDL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDL2"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="41218" checksum="30BCDCB9700F8EE6" modified="2022-01-19" version="1">MSFLGRIKKPTASSFGCRHHRDWPIEIAGSLSNLPPNGDPSSTTHSTTRSCCTTPPSPSLQTDTPTSHNENAEFPSTYHSDPTAFPPNSMAEGYFDVFFRVEKKLGRGSVFWSLRRQKTRSRSIPYLSLTNFKRGKAFGKIASSEYCCVSGGSLDDFIERRIRGFSKGKGLNGNGNRARGALNRGRGRGRPSGETETETKAEGEGQGQGDGDGEAEAEGELERQKLIKHAFGARARKQRERERDREGGAYTQRQKPYPESSSLSPHYTNSSTPNSSRRKAKPKPSLHNPKLKTTTTHTRPRPFKNSLFSDIVSDLDFLHSRNVLHLDMKPGNVLLRFDHGYGYGYGEGGLPPGMSSRSRTFSFAQRQTPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDL3</accession>
    <name>A0A8H5GDL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDL3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="457" mass="50746" checksum="3F4C0C0C20741970" modified="2022-01-19" version="1">MGKGRRSSIDLQLLPYICNFYHLQSHPSLLTMSAQSQYNHNAMQRSNARRQQDREMGHQYRTQSPVEQAGDPPAYDTSGNSNNIHDRSDIQVVHNTIHGSQHVSTSHNNSTTTDSYQTKNVTSVFSNNIGSNHWDSNNCVEGNVGSFNGTTVQQVMSAFGSTSNAMPFPGHVPTNFTSGSWYSNNHNSNHATSGNNISNNRDSFNATARGEVSLFDYFVNVLIYPPPPPDSFGNQANATESHRYNMNHHRSTTSHNSQLLNAQQQSGSTVWSYNVDSNYFDSDNRIEGNVRAFNGVSIDQNPISAITGARARNNPFSQSVPFNLNTAGGITAYSHNENSNHSNSRNTISNNTDSFNTAGAVNPLEGLNLQQVEQVIATCRSLGYNDEELQDLRLEHWHHEVLKLCLGDGGRSADQSAHDPLHQLMQKIRRHRSKGHVIPNRTKLVAPFDAVYQELLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI84</accession>
    <name>A0A8H5GI84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI84"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="141" mass="15384" checksum="5176CAE384C1BE3D" modified="2022-01-19" version="1">MNDQRSIGFSGCHSFATDGNSVKRLRGGRITMANSQAKGHGGFFTEAAEFVKAMPNGDNVQDPTSPAGQDNFYQNCDHFAVRGLEVAEADYELELPENNVNPEVIQMILSHLEKQKSAQKDPEPQRSQPEAQIVKFGSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GID9</accession>
    <name>A0A8H5GID9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_003333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GID9"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5365659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="352" mass="38757" checksum="673B6A9E1BB5AEE3" modified="2022-01-19" version="1">MASLPEQSSPNPLLFPAYTPFSSTLNRFQKWRADLGLPNPGTVENLQKEVKATHLTNYAFDGGRADLTKSISMNPLFQVTHSFALGSQTMAPSYNFGAIYASEKVFLQGGVDHDGNVSARMNQGWTASHVSKMQAQISQQAGHNLLQLEHDYQGMDFNLNLKAANPWPTDLTGIYVGSYLQSVTKNLALGTEWVYQRPTPATSDLVATYLAKYTSSDKSWIATAQLQPAGILQATYWQKLSEKVEFAADLQLMAAPMRRDALATLGAKYDLRLATFRAQLDSTGKVSALLEQRFTPTFAFLMSGEIDHFKNAAKVGVGVMIESSALSQEELEMQMQQMQMQQQALSPPPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIJ4</accession>
    <name>A0A8H5GIJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIJ4"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="42685" checksum="9439AAA120E911D9" modified="2022-01-19" version="1">MKLSFSLKAKPAPAQAPLKQPAAFASLDDEETTDVAPTSSTDRDASANKKLLAQNVTISNKMKKRMEAEKTVDESVYEYDEVWDKMQEAKQRQKEAKELDAKERKPKYIHGLLASAATRRLDHLRAEEKMMQKQREAEGDEFADKEAFVTQAYKDQMEEVRKAEEEERRREEEQKKNGGRSTGLAHFYRQLLEESEQSHEATVAATQKPVIGPQPNLTITKPPNFSPKTDLELARIARAEGKEVELNDDNQIVDKRELLAAGLNLSGTNTRNLKMRLEADKSQQASEVVQSHRAAGTAASRREINERRNREIREQMEEERERVARDKEREEREAIERTVAKRNKEEDIQSARERYLQRKRRKLEVEVSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ17</accession>
    <name>A0A8H5GJ17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ17"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000077">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="489"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123760" checksum="CA105678FA4B6357" modified="2022-01-19" version="1">MFHVRCMIQESSCSMLAVTTGVNKHVAMTHPGCRLDTAVMDDLDCLSTASSGSMVEIKRTEPLQSPVQSSSRFDEEDRYRLVYTKSKVYVNPTAYSRDNIPGFVAIVKRAIFIQQAANPTYLLAWIPETLLNEKGATEWDKFFKVEEKAILDQEDDDGSIGINLINGDTLPTLHFHDDESRSFTSPPPKPSRNTKRTSITSYPPPASPVSPSHSSTSWGGEDLIARLRCYAHVLPSVLQPSLYLIDPSRADLETHSTQIFDDDAVDDILAQSSYANSFSPVPAHRKPRPLSSPQGSLSPNPYSHRSSVLHRSLGSASSNQQSPSQARMALLQSFSNITRATRHAAQNILSHPLAKPIVPHLPDPVKTFVNANGEWEWGSWVEKGGVGEFESARVYLARWARIVAEEGERARRKEAQTITSSSDVTEETSSLGIFELLHSNANNLPTPKSSRDPAHPVDGKLWAKWFAEDGRPKIRIEEMKREIFRRGLANQGDLRKKIWPFILGIHDWDITQEERDRRWEEKRKRYQEIKNEWCGVPEVFDRQDILEQERHRIDVDCRRTDRTQSLFATPTATPSIIKSSEIDDEKAGYRGYSTISPNLVDIGAQSPSNEHIDRLAGILLTYNFYEKELGPAIGYVQGMSDLCAPIYVVMEGEEEMTFWCFVEVMERMKQNFLRDQSGMQKQLSTLRQLIGVMDPELYRHFEKADGLNLFFCFRWVLVVFKREFHFDDILRLWEVLWTDYYSKEFVLFVALAVLESHRDMLLRYLVEFDEILKYCNELSMTIELDTTLAQAEVLFLSFAQLVADIDRRQAEEASNTSNGLRHRPTGSMDEGPAKKSPTVSQDLRDLLKTERQTLTIYDAYPKSIFHFLLLPRVKPDSGLTVNDLESLKTLLAGDKTRAKKVIDALNEDARSLRKEIEEEMEKRYGFKWPIWTGFHGAPSMHHLHLHVLSADLCSPKMKNKKHYNSFHPKLGFFLHIEEVLSWFDSDPSYFKTKAALKEKEYEALLKEDLNCWKCESDMKNIPALKTHLQEEWDKEAARGKAKAEKKRKLEEKRKDTNSVQEKAEKEDRVGKRQKIADTSDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK65</accession>
    <name>A0A8H5GK65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK65"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000181">
        <property type="entry name" value="CALML5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000100">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="138" mass="15323" checksum="7CBE18899AD112ED" modified="2022-01-19" version="1">MSDQLTEEQINDGDGTITTQELGTVMRSLGQNPSETDLNDMINEVDRDGNGTIDFQEFLIMMAKKLQDTDTDAELRAAFAVFDSDKSGSITADELKKVMKKLGEDLTDAEIDAMMKEADVNGDGQINFEEFQRMMAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKY7</accession>
    <name>A0A8H5GKY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKY7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="171" mass="18237" checksum="010D6C2A0B638F82" modified="2022-01-19" version="1">MLLLPFAIQAITVLIRASGSTIISDNNLCCSRMQFKEFLSVILLAAGIACAAPVAKPLPNADLDVLRREPGGYYHDDDLIDVAIVADVLDLVDVAVGVDVGRRDPGEYYHDDDLIDVAIVADVLDLVDVAVGVDVGRRDPGEYYHDDDLIDVAIVADVLDLVDAAVGVHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKY9</accession>
    <name>A0A8H5GKY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKY9"/>
    <dbReference type="OrthoDB" id="2962003at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034354413" evidence="1">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="212" mass="22461" checksum="7EDDB673B7E63A09" modified="2022-01-19" version="1">MRSYNSLLICIAALFCIATAVPAETTVTFLGVVPSEIVDLYTRSRSSTTPIATPSGESGPTTSINIAVTPIGTAKDGSETTYSLHEVISINRDPSSGDVQPYTVDDIMVNYASGYRDRASQVFDPNNPGTVTVGVLSENCTYNGDGSGVCLRTAAGQPNGTTTYTGTVLPVMTVVFNVDENGAGLGSRSVQGEELWMLMSLLAMMWMFVDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLM9</accession>
    <name>A0A8H5GLM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLM9"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="138"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="446" mass="50313" checksum="69892CC0E624C9DE" modified="2022-01-19" version="1">MMKRINKVEGLSGFLKGFVPALLQGYLALFLAHLASPVFVIPDGDGDDATSRTYLILRFRHFLVTVAGIPLSIIIKRAIYTPCILSFGSYKPALSVLLSPSERLQPWRLYLSPRIFAVALIEAVMDLALEFYFHPLFYDWIIRSHPSAYAIRIALYKFIDIPLEVISIRLLLRRHGVDDNGTTGGNPSEVAGLRKYPAHAYVIGSRQGPYTSLYDCVVKMVREEGWMVFYRGLIFSCLRPGLLRSYHYCSLSWTSFLSPPARSSLSTWTHPLVLQGAWETTMSHQEKAMVRPWKDVDQAYVRLEDMKSVKELDLYLPRTKSTSPKSAGLAGEVVGLESCEEGIHGGARQPQPTILISRLFYWGFVCPPFWLSGVIFWVIRRSRPVYGASTNATVAATQLQNVERKYAIRCLYAFLIFSVTVVGIAVTVWAVLVLKRFERDVKGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM66</accession>
    <name>A0A8H5GM66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_003646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM66"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="695" mass="78320" checksum="22D37D14683FAA2C" modified="2022-01-19" version="1">MFARTRNRPIRNFCMSRHANSHLEQRKPVQLPRLPVPDLSKTLTKYLASLEPLLQEESLRTGVPYAQAYAFRAKWAEEFSHGVGKVCQERLKALDRASPNNWLDDNFWLKSYLDWRAPLVLNSNWWMIFCDDQHGSVPSAEPGFTNWQLRRTAWLTHRILELKDKIDNQEVYPDTSRTGIWFRESVYKIFNVCRIPRQISDTLSSPPPPDDILSQYVTVIANNWFYALRVYTRRFELIPASEILERMAAIARDAFVRGQGPMIGALSADDRDIWAKNLSHLLSLNPQNEKIHQAIVRSLFSVTLDSQTHALSESEAKSRSTSPVASTSQSQVSLDAHLHSVRSVPSNVSNRFFDKPITLIVDPSGQAGVMGEHSPCDALVPSMVGEYAVVQCVPDDFGVDTNVNAQAEAKDVDPQTRTEGDDWYRLDWITDSHVLSECVEAKKRAELVIADSDNSVLWFEDYGGDWIKSVGLSPDVFIQLAMQLAWFRTHPNENRFTATYETALTRLFHKGRTETIRTLTTDSRRWVLGMEDASMSPQAKHSLLFRAHRTHTTLTREAMTGRGIDRHLFGLRNMLTAKEQSGVNSDNQSNNSSGSGTGIELFTDPLFMKSADWRLSTSGLSAGLLFKGTGFGARCEDGYGINYLAGPSMIKFGIESKFSHHNTSTEGFKRAIVGALRDMHVLCVEVGVSDVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMS0</accession>
    <name>A0A8H5GMS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="813"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5367500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1322" mass="145130" checksum="B653A8E66398AB6B" modified="2022-01-19" version="1">MGNTWITSSLCSTPQCEAVPRYPVAYQSPTFESVNGNTSEFHASYADGTAFITDSNVTMIDEVSGIMGLGFPRISTINGTATNSTPLFPGLAQRAQLSYPLFGLHLTRDDTGSLTFGAIDSSVVTDVSKIVWNEVVEFPPFDNEKDGPSYYQWAVPLEGISADTGIAEHLVFTDLGRTKRNFTLTPLDYMIGPASGNPEICLSWPRAVTPSPDGIDWQLGSPFLRTVYSVFSLGIDDKEPPMVGLYPLPRNVSESTEPISSFLSSISATVETTLPNSLLGTPSVTPPPYGFNASVTAPTGGVVSTGLANNTYSPIFGADTTNLSAIPLITPSPTVETLTTTDSAGSYIAMKKKRFQASKWQVCNAFLATLTCKARRTGFGPHFYSYTSMATGPKNNLNDILKRRATNPSLAQSSSAPVPSKVSASKFKPSNGAASSSSLNLSSSLRRIPTFSTPGFGKVKPNASATPDRSFASSPSKDPVDIIDLSSDSITVSPGTKRTCDSASLTESQSSTKRSKYDPVEKENYLINSSPSMDKGKGKVIISKVKDSLHIGSSSRGDKDGKGSRAAKDMIAMKQDDVVEILDDDNDHDDWLAKATKTTKVVHPNPYVQLDIDFPLSPAKKSPSVPEKLDPDLLKRPLSELEEFLSFNRRLLQNFEQFLAESIFIDKPLADEIKSKLEGRIKSIETVVQTRKSADATTTSPYFSSTASTLLASVASTSAGPSSVALPSSDSTPVLMEDATFDDTASTNSDEALWDNFEDMDLPMDFDIEGPSPSIPPVLDDKFVDHEYYPEIMDNLKMVFRLQSFRPNQLESIIATLSGRDVFVLMPTGGGKSLCYQLPAVCKAGSTKGITVVISPLLSLMTNQVNSLKEKKVDVVLWNSESTDVPEIIARLRGYTKPSLLYVSPEKIKESGSLRNILADLYHSGQLARFVIDEAHCISTWGQDFREAYQCLDSLRDDYPDVPIMALTATANDVMVKDILHRLKLRNPAQFIQSFNRSNLKYTILDKKKVVDDIYAFISSKHRNATGVIYCLGRDKCEKVAKQLRDKGLSARHFHAGMPPDEKAQVLGDWEADRVAFGMGIDKPDGRAGRDGLLADCVLYYSYRDYKAIVKMINNPSNNEKVDQDSIRRQETQARIVVEYCLNQSDCRRVQLLHFFGEKFDPRHCGRNCDNCSYQGEVEQMDVTKEAKNIVLLVKYFQDHNKQVTLDHCRAVFKGADTSAIRSKGHQHVPLYGKGSHLSNELLEQLFKRLCLEGATDEVSVIGRNGWHNYYFQLGPRANDFLAGKGKAVELNYRPKKASASTKAAPRLRNGRMVSKAKKDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNI5</accession>
    <name>A0A8H5GNI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNI5"/>
    <dbReference type="OrthoDB" id="2840262at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="110" mass="12683" checksum="29774C7FAE542A5E" modified="2022-01-19" version="1">MMWPIIDAEREKTLHEELNDKEREAIYSSLSAQYLPALVTAYKRIPKESFAISSIYTALLRNLVANGYFAKLKFMRSEIGKDLYRVHAQKIAEAADSDPRSFIVCFNYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNX6</accession>
    <name>A0A8H5GNX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNX6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="400" mass="44038" checksum="95F97FD1E60DC8D3" modified="2022-01-19" version="1">MLAHPPITRRIVHHSFKNVRLNSTDSTSARKITSWGGISIPDRETTIRTNDIQRQTDLRMRARPSLASALATRQAVTEADPVLASPQSSERAQTAQFSRGNAQPQYSGPRQTARASEQQPPPFRSRGPSRQSEVGRSSRTLSEPTPRTAGSFSETEKVVPETATPKDAAKPQTQTSSKSYSSGTGSFNGVVWTPQTGVKRQGRNEGQQQSSRGRMDNDRLQQGRSRRDNDNFQMRGRPDGISSRPRQGSFASAPGRRVSKRRTSSASGWQSTSNTRLSKTTAETPDENDPYSGGPNEPRLTTPDVDIRDHLDKVLGIHEQKTGLPAQVTSKRRTVNTNLVLEKYGGDYSNLVQDFSTPHAAAVRRVADVIMSRRPEVLSGSRLRFETIVEAGVRASRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQQ8</accession>
    <name>A0A8H5GQQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQQ8"/>
    <dbReference type="OrthoDB" id="3038309at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="399"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="983" mass="112362" checksum="9DD70B2A824D6F77" modified="2022-01-19" version="1">MSPEDSCFLVITVLNLPFGDIVGSYVVIKHGSERYKTMRLDGTKSGAIQWDDRFELKLSSITDSLAFELRRRRSFFKYISGPSRLLGTSQVQVRELVQCRDQGVEVLVNNRDRNIKFVIRATSDFKDSVEEATTPISRDLIRSEIADSTPLTENASNTLQVVQMRDARASESDLPTRSVDLGPNPHAAILKPSTLSKVVEAADPIIQVLERLSKVHPIAELAWIAVFGIYEIVKAIDKRNQDIVALYKAMLDTYQMATQNDSLTETLKSDSNFKSIFDTMVKRSMDCYMFISDYQSENVLRRIFQSNDVQNLISEYTQIFKNLEKQLTETQIKMTTVSLLRITPQIEQISNKFADLYIDKNLEPLKKGNTLPPKSHCLHGTRRNTVRRIMDWVVKGKEPIFWLFGVAGSGKSSLMGTLHNMFVDMGFKSRLAAFIRFDRNDYNNASMFIQTLAYKLAHFDHRLAEAIVDVLAENEQIVDVTDISKQLDRLIFGPLRKHGEDLRKEGSIIIIVDGLDECTRSDHSETNFRGQLLKLLVENPFQDFPFVRLVLASRPEEDIKRMLTGRKHIVAFPLDTTTDETQADIKHFLEHKLSETGLHSGSTFLELCHERDAVNQLSMRASGLFIWASTVVTFIAGYPEQRLRRILDTDVPVNALQALNTLYTTALDSVAGEGDSNEDIRADIRVVLGRIMAANSVRPHVWSDVLPLTSAILDRPCTGSSAVKSVNATRVLEKLWSIVQKEEDETLSFLHKSFDDFLTDYTRCPKEYYIDVKEYLLDWTFICTSYFIDFLKSNVEYPRDGPESEADIAFLDFAMVSWNMFVEKLSFQDLESRPDVRDALKTMLQTYLLRLMYLGKSKNRYIGKLTDEKLENHSDFGQLICDSSEFITCVGIFEERTARMFKRFQWLCHKRSSRMYDYYMPVFVAMASGSRRYPDIIEAIEKDLAPPVLDSGSLDVDSPIEILEIPEKIILEGPKPARRRFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQU5</accession>
    <name>A0A8H5GQU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQU5"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="239" mass="25850" checksum="E2A75051CD5C0701" modified="2022-01-19" version="1">MSIVLPGELVPAQHVNLKLGPGLQQVQTGQASTSRAPSSIIATRAGALHHSANGSKWWIESNSRRYVPAPQESVIGVIVQKQAEGFRVDLGSAHSANLDGLAFEGASKRNKPNLKIGSLVYARVSLAHKDMEPELECFDAQTRKAEGFGELKSGFLVRCSLRMCRNLLDPNHFLLPLLGALFPLEVAVGLNGRVWVNSKEAKHIIAISRAIEVADPDGDNMDAKAVKKLVEDLDSKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRA4</accession>
    <name>A0A8H5GRA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRA4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="94" mass="10326" checksum="1A3944DF288FD550" modified="2022-01-19" version="1">MSIILNSLNYRESLRERANLPQESGKLVQLSPLGESLRLRSDSNQPSPLRGSVQKDSVYHKVYSSSNFSSALPSTISPTFNQSPLGVKNFTSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRN5</accession>
    <name>A0A8H5GRN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_001329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRN5"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="11">
        <location>
            <begin position="57"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="20251" checksum="267812F65684D13B" modified="2022-01-19" version="1">MGRCGMQVVVKKQVNLLSTFMSESVDCPQQKKRKMSPEASAPVAPISQLLVKRLSPKAKIPSRGSALSAGYDLYSAEKKTVPAHGKALVDTQISIAVPAGHYGRVAPRSGLASKFMIDTGAGVIDADYRGVVFVLLFNLSDKDFEVEEGDRIAQLIIEKIHTPEILEVDDLDETLRGAGGFGSTGGHGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRS1</accession>
    <name>A0A8H5GRS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRS1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="185" mass="19972" checksum="3A8A9809717A9863" modified="2022-01-19" version="1">MFRSAISRTILNASRPAVARVNVRPALTRAYHENVISHYERPRNVGSLPKNDIDVGTGLVGAPACGDVMKLQIRVDENGIISDVKFKTFGCGSAIASSSYMTERVKGLSLDEAGKIKNTEIAKELCLPPVKLHCSMLAEDAIRSAIRDYKSKRATMDNPKQSGFIDVTQSAVTGETVATAHPGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS23</accession>
    <name>A0A8H5GS23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS23"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF393">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="519"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="628" mass="69534" checksum="DADDD02BAAD450E8" modified="2022-01-19" version="1">MAWKPVRTIAECDKILSGPGSIFEVETLLIDGRVQRAYKNLWPSMRAFLLWSCNEFNDKVFIVSEEQQYTYRELLERSAKTASIFRNHCGVEKGDSVGICSRNYPEYLVMFWACHLLGAVPVLVNAWLPLDGIRYCVSLSDCKILILDPERASVLEPEISQIVKDIKLKDVFVLESHEGKGVWAGMSDWKDVYNRYRGDFSDILNNDPHILPEDNAAVYFTSGTTGRPKGVLSSQRQYLTNVFNSANGRARDALRQGIELPDMSDPQKGMLSRFFVHLFVIELESCAVSVPFFHVTGTTSQMMSSMMNGLKIVLLRRWVPEEAVKYGDLTQQKDISSSVISDRLIKKHNVAVAGGVPSMVMDLLFRAGEFKLESLTFGGASASPSLAETASRVLPEASLGQGYGMTECNSVAVGIVGKDQVLRPASTGLPTLVNDLLVMDLEGTKAVPPNTLGEVWIRGVNVMKGYLKDPEATDRTVTKDGWLKTGDLGYLDEEGFLFIKDRIKDIIIRGGENIDSISVENAFYALPSIYEAAAVGVPDPKLGELVAVVASLKPEYHGKVTERELIHAVQKSLPRFAVPSLVVLQNEPLGKCLFTKRTASGKIVKAQLRMQAAKEWEKRQGGVIKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT12</accession>
    <name>A0A8H5GT12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_002080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT12"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="12368" checksum="2D778F4E7C2BBD72" modified="2022-01-19" version="1">MSGAAASAGTSKFTAFMNHPAGPKTVFFWAPLMKWCLVGAGLKDLSRPADKLSVSQNLALTATGFIWVRYSFVIIPVNYSLAAVNFFVGMSGLTQLGRVAHYRYYGEGATKPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTS9</accession>
    <name>A0A8H5GTS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine aspartase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTS9"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21072" checksum="49524F8970393205" modified="2022-01-19" version="1">MVSEKASQRWQYWKERLQSTEDKEAEQGFHDIQDTVGAVASCNGHMSAGVSSGGLLLKYPGRIGEASAAVYGAGCWAQEMRGRKMACSISGTGEYIIRSNLARTIGKVSNEDDLHEALERTLTADFWGTSPITAHLRSHSGAEQSRNAGEPNPNAGVLMMTADSETTVRLWCAFTTPTMAIAYASSTNPNPKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVW3</accession>
    <name>A0A8H5GVW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVW3"/>
    <dbReference type="OrthoDB" id="3256662at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="614" mass="70685" checksum="EDD4FB49DCA501DC" modified="2022-01-19" version="1">MQALADYFVPQLNGFLSPWEDAKLRDVGMGLRVLGDGREPCSIPYEIYEEIFLYFDPRPERFDHNNSIGPFYCKQVLFNLSCTCRLFRVIVLPFIFHNITIVTHKDHPHAAKIYTFCEELVQVHDSQSSSPTSRYPRCIAPYVKECHLLGSKADMQNDGHPSVHLRALSHFRNLQTLHLQKTPINRDLFGTVLPKLKNLTNLVLDNHGIHSEEELRGLSTYSFVRLHVGESDSRYRDQSLCSHFSTEHLEEIETNGHHIFETLADKGPMHALQVLRITPSERSPLSTPGLFCSLLAHAPNLVELRLGNIIVLGPLPREGSISLLNLAHLSCPDQMIPLFSFSVTEPALRELHLYPSFRDTRENMIPPPICYTVLPGHIAACMIELKIPYVWLVGHYKDEDGDLYTYAPHFDQYFPRLEVLSVYDHAHTRNEHTLFKKDPARHHKYKKDLFARIIKICQGFRNLREMNIFVDKCYFLKQHRSSRGPDIPWNLPLQLQTVRWTRVGYEATPAEDDTEDDERGHSYHTGAGKKSQTLRIGQLDMDAKAFGVQNETEETATEAMDPGDSEWIPHVPYPARFDSKFRVERKAEYINDWTPCKIKSLIIVTSMQTRSVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXJ3</accession>
    <name>A0A8H5GXJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXJ3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034394181" evidence="7">
        <location>
            <begin position="27"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="9">
        <location>
            <begin position="451"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5372911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="611" mass="65853" checksum="7E81E177B8360EDD" modified="2022-01-19" version="1">MSLYLQLAFLSILEIILLLSSPFSYAKLFTRPEDVPSRTYDFIIVGAGTAGSVLASRLSEDPHKSVLVIEAGVSDSSVSTIQIPFLASSLRQTSVDWNYTTVPQSGLNGRSLTVPRGFVTGGSSSINSMAWTRGSSDLWNSYAKITNDVGWSWDSIQSYWKKISTLVPPTSNDAITPDQIPLSNSNGPVLVNLPNYDIPPRQQVFDAANTAQDPRFRFTRDVNSGDSLGFGYNQASAGHGFRSSSATAYLNPALATRSNLDLLINTRVTRLVNDPVIQTKPVFKQVELAQSPHGDHLLFKATDEVILSAGTFGSAQILLLSGIGPKDELEKVIVDSPDVGKNLKDHPVVQIYFTVNSTDTLDSIFRNSTLTAQLLAEWQQNKTGILSDTPINVFGLLQLPDTFFTSVDSNPASGPKSPNLEMIFNAFSATPTAPAPSAGNFLSVVIALVSPTSAGSIKLVPNSTDTFTAPLIDFQVLATDFDMSAMVQAINDTEKFLSAPSWTRDGYLIGPFGEFANATTADARLQYIRNNADTIHHPVGTLKMGRNSPAQRLGGEGVVDPRLNVRGIQGVRVVDASILPAIPECHTQAVVYIVAERAADMIKQAFGMLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY65</accession>
    <name>A0A8H5GY65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-nitropropane dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY65"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="39490" checksum="7EB6C0EE2D3443B5" modified="2022-01-19" version="1">MSTSSFPSPIMPSSPQVFETPLTKLFGINHPVMLAGMNVAAGPKLAAAVTNSGGIGVIGGVRQSPKFLKGSIEDLKSHLEDKKAPFGVDLLLPQVGGNARKTNADYTDGQLPELLDVIIQGGAKLFVCAVGVPPKWAVDKLHGAGILVMNMIGHPKHVAKALAQGVDIICAQGGEGGGHTGDTPFSILIPAVVDLCKNTKSPLTGEPVLVVAAGGIADGRGLASALTYGASGVWVGTRFVASEEAGAPKKHKEQVLTASYDDTIRTTIYTGRPMSVRKTPYIMSWSRETERVQEKENLLASGKIPHNYSDERKQVELEKHPEKSLSGMTWLMGKVAGSINDIKPAKEIVDEMVVTAAKTIQRSNSYILPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYZ9</accession>
    <name>A0A8H5GYZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleotide-sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYZ9"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44579" checksum="5297B645F196DAE3" modified="2022-01-19" version="1">MSLPTHSTSHQLKSYNVYEQDGDDLGFANDLNATTPSVPSLWGVPLKYISLVTLAVQNSMLTIIMHYSRVSTPPSRMYSAATAVLMNEVLKGSISLVIAFWRIESEKGSSPSSCRPLALADRARKLSRDIFSTDCWKLSIPAILYVIQNNLQSSALSNGFRSSSFLAVGVAIVQIQSGAGNHSSSSSDLPTMNATKGFIAVVAACFTSGLAGVYFEMVLKNSQGDLWVRNVQLSLFSLLPCIAHIVFSHESSPSFGQPGWFSGLFSNFGVWAWSTVLTQVLGGLVTAMVIKYSDNILKGFATSLSIVISFLASVALFDFRLTWTFIIGSAIVLNATWLYNQPAKRVGFVSGMDLKSWGASWTEKWRSNDSQPSVAVPVYGSGVVSHPASRTGSLISLSSLSSANSSMTMLQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ26</accession>
    <name>A0A8H5GZ26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ26"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24410" checksum="95482C88A0FA2F6B" modified="2022-01-19" version="1">MQVPLGFQRIFSSFPLHSWPSAPESRKPPTEPTLWIHPSNHVDGLSGDVDCLKWQAYLALRGLKNIRVRTDVHPQGAIDHRLPNLHVEGDRLLPPHGIPAWVDEKLGKQKWEGYISEAAQDESRAWVSLLQGHVHAALIFAKHPPSLKETLLEMLSPFPSFTPPTANLQSTVVPMTGFLSLLPPIGIRVDAESINTEYAQAIQALSDRLSTDKWFLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0D3</accession>
    <name>A0A8H5H0D3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0D3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="373" mass="41088" checksum="43C4C21C3206DBAC" modified="2022-01-19" version="1">MRRAFVKADFRGKNKNRETFVAITENKNQPGRWPAQPEKPFHKRTTIQDMKRVILDERKGYTTTAPHPDSLVHVLNYGAITVSKAPAALKKTLPSNAAPITAPTMPTLATQELACFLPLVSALLDILIEDQCPESASQPNISQPINVLYTLINSMQTQDLLQVLQSSATRITGVICVYTPNPKHDGYKTIIIDSGTVGTTTPSLPFLDIPESKSIRLVVSPSVLTTTSKTAAPSSVATSSTLKQGSGDNAPLSTAGSVKRKHINTSAKQEEVILWLQDELKVQDNFDYEKDLLPLLSHLPLQNPDAAKLWTWIGKFVRKYNDRKCPVNKKSVMKVAIAQALSRRQTWLVGIEEGYHYISYYGAGGKSPNAEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H191</accession>
    <name>A0A8H5H191_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H191"/>
    <dbReference type="OrthoDB" id="2575000at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="25326" checksum="6D71C564CD303780" modified="2022-01-19" version="1">MIAGLAKAITLYLAPVLLLVALVLNLFAFLSPTVMLPDRVALVTITPSTALTDVGGSKDVDGASLFLGALGSCSRPKNDADINCTVASLSPEYDLSVLPSNAPQLVLSAPPPSSPAFIAVSLAFSIMFFFTFTLISFRHKMGERIAAQLDKPLIQRVSAWIGFFGFFIGISSFLILRMWFGKAVQDFNRSVASQGSEGPELIASDGNAFTMVWVAYAFYAVPVICSMAKLNVTASKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1K8</accession>
    <name>A0A8H5H1K8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1K8"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="736"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5375271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1228" mass="136196" checksum="6A20EE2FDAA14DBE" modified="2022-01-19" version="1">MVISRDTSDRRKSIAVAQPSDAVIPKRRRRATSFAPGDESPRSRSKRISLGPIRGILKRRSSSQPPDARISSASQEDGIASMDLTTDYQEHIRDNFTRKSLSRRVSFSTHSDVREFKSKRVYQESSGSYPSQDLPDMPSSDDFPPVVNDENAYPGSTRSRRSSMRPSFAGTEDMDLTSTSLFAHGDEAAIADEEFDFEPQESDMDVTEAYSSNLKGKRSLSTGGSVQRPPLSQISDNPTPTSDAPEDLSQSFLSDQSMLSDQAEPRRFTIPLGQPLRPAHEDETWLQLVAGTHAGVATVEGSDSEDAIKDMDVDDAIARVVRARQSLNLAQREEGSMVMSEDSFENSFDPGDDTVDISRMMGKGFNSRDSRAFQPSDDDMDMDESEIYGEDHGLISSTPRPSLAAAGGDLPDFMPDPPTPQAKPTEPTRSPPPTVFSLPPSEVEHNAGPSTSNSKALVSPTKGSKSPSKTPTKGFTAAFAPPVSKPSPKKPSTPVDNASSLKRPRISTDVSHADEAGKPSPAKRQALASRWSQAASPETAQSPPPTSPNQEPRPLDPSKKAPFQAAPPTEKPNSKPNSLRRPSGYLARRKSLAVGFGATPATAENAPSVTRTSPKKKASIGLGRASMGSAASSDAWKRFDRNAEPVQVDFGKGREKGKDILPQAEKLVQSSKPNLLPPFSVQQPQNVDMVQDPGPSSPSVPVVDLSTFLDSEHLEDEDDHVDVDMAAATEQWRDAIPADGYSADEGPPISIEQFFVMTDIKFMDELTAPRRSMHPSQQAQRQPRNPDEIGLAEYAVASSIDTPQLALYTRVANDLEGWMKQSKTNFEQCEEEAGRMTPQLFTEFSSAGEKEQEELKQHLKLIRTNTRGHAKSDWYDYKLKWIDTLRIPAEKYFTELQNDAKALANVKAKCDEALPSLEQEYEQVMRELEKEQAEVAAIEECDQNYLTELKNSITDQNHEIDALRNEEKEGLDQLVWLKERLADIEAHKREATTAINEASRLLDLQKNGTRSEVFRLKEELETLEDLHMFRITKVNANIFEYVYASAYRVSIPCQKYQPVVEKIDIVPVPESSRHKDDFPRLKNFLLSAAKHMIRNSGESTTRRIVQKLSDYWSSCSQLCLQFRLLSLRYPLEIELNQSSAKPFSEFRAQIPLLFPSRKSKVIVSFVFNRDAYSRWPVSIKSMRYEVAVAYGSARAEDVSNALQKRLSEASPQGNYACLLDACIIAQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LG47</accession>
    <name>A0A8H5LG47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anthranilate phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LG47"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="4">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="4">
        <location>
            <begin position="211"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="4">
        <location>
            <begin position="365"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5356379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="53118" checksum="AE88790EBB60EF8B" modified="2022-01-19" version="1">MTCTPDTFRPLLKRLVETPEYFSSSDLVNALNHIFTPSALEPSQISAFLTALHIHRVERRPESLAAAAQVLRERSLRCQIEGLGEDGDFVCDIVGTGGDGWNLFNVSTTAGVVAAGAGVRVIKHGSRASTSSSGSADLLQALGCIFVAPPPIPNDPEKVKPSTLKHFIPKPELYSPNPTPPDSPTTPTHSQSSSNDESSPSKQKYTPLPSIPFTFILAPHYHPSLAYIAPFRRQLPFRTMFNILGPLINPARPKGMVLGIAEPELGWTFARSLREGGVERGLVVCGEERLDEISCAGGTWVWSVGVDLEEALGLGDRSSSSSNENTETQNQDLDAKTQTQRLRDLKDLRKEEQTFHDSSVYGPITVTKIRVTPSMFGLPSHPLSEVVGGSPEENAEVFKGMLQGKGDSDSSKNSDPTTPTPTVGRIGSNPNANLTPFLNFTLLNASALLVVSGVAKTFREGTEMARESVRSGRAWEVFERFREVGGGARGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGV4</accession>
    <name>A0A8H5LGV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000053">
        <property type="protein sequence ID" value="KAF5356677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGV4"/>
    <dbReference type="OrthoDB" id="2677917at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF104">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="644" mass="73271" checksum="E9C08D1D927484A7" modified="2022-01-19" version="1">MPPRPEPPIPEQLQSKEKKRKSISTAKANSEDPIESALPTKKAKTSGKASGSEAPKKAKPTPKTVVQAAAKKLKDTLSKTKSKKTICNSDEPDLPQPAPSKAFTVDIDENSDDEVQPAPSPPKKSTGPKATVIDADDEDDDGSDSNVEEVLEEETDEAELERLMKGWHSVVYAFFEPIPTVEYIKGRKCQVFTCSSPSCKKKIHQFQDTGDAKAMKTLQNHVNTCKAWGPDAIATVKELTVPDAHKSLSRYLRDGTITMAFQRGRKGRGTVTYSPKQHTRAETRAELFQKTSYKIINSPTGLLPEWRHILHEEKQLQTVIPRDVTTRWNSSCDMIEYCIEKKKYYRAITSEDLENGLQQYALTKREWKLAEQLKDVLKVLHDATLFFSCSTPNLATVVPVLDEIDRKFTEWALNTTLDPAIRAAVSLAKKTLNKYYGKFDYSEVYRVAMVLHPRHKLNYFKTAEWPESWKNMALEIVRDVYERDYKSKMTVENDAMDVDEPETPVKPSKRNQFDDLPALKAPRPDDLSDELDRYLKSDVEKVKDVVEWWHGRKKSYPVLHRMALDYLTIPATSTDVERIFSRGRFLLPYICNRLSAETTRALMCLSQWSLLGLIDDNDVVEVSKLPEIEVENKDAEDRRLKTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK53</accession>
    <name>A0A8H5LK53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_007567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="79"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="455"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="640"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="1111"/>
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        </location>
    </feature>
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            <begin position="1310"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1584"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1845"/>
            <end position="1902"/>
        </location>
    </feature>
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            <begin position="1914"/>
            <end position="1978"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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            <begin position="218"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="8">
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            <begin position="1016"/>
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    </feature>
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        </location>
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        </location>
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            <begin position="1358"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1391"/>
            <end position="1402"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="1775"/>
            <end position="1792"/>
        </location>
    </feature>
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            <begin position="1796"/>
            <end position="1805"/>
        </location>
    </feature>
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        <location>
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            <end position="1872"/>
        </location>
    </feature>
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        <location>
            <begin position="1888"/>
            <end position="1897"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5360023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1978" mass="210093" checksum="C528D6A277221ACB" modified="2022-01-19" version="1">MSSSIEFPSSSSSSSSNPTPIPRHLPFRRISLPTKPSQIAIPKPPSSNSPSKPRRPITKSISSSPSTLPTVGPDPSLPKRIKIISEFYSTEKAYAHGLNLVYELFLTPIVASLDTSNPMLSRAQMTNIFSNFIDIWNLHTSFLAALETVLFPGIHEEDENKEQGEGGGRKELPPLPNPLPPLSPILLAHFPYISLYTPFITSFPTTLSTLTALTTPPSSLPAGIHPPSSTSHSSSSSSPSKPNSNLLEYNPSFHTFLRETERNPRCAHLHLRDYLLTIIQRTPRYILLLKDLLAHTPPTHPEYAPLTQTYRMIERITESLNTSLKDHAEVLSLLALQKNVQTNTPKSKETTGPPFKFISPGRRLVKRGRLVMVERSEAPREREVVVFSDLIVWLDVSGEGGFGGWGQWAGGLNNIFSGNLFGGVSGLGEWISGLWGEDVEERVEAEVKISRPPMIRTRSKSDAGVSGSGSGAGIGTGTRIEAGKETTTASSTTTTTTTTTTGTSTTQVATTTSSSSSSTPTSTSISTAAVSHISAVGTSAPAPLGYKRPIRTSFTAALFTRPVFPSHSISTSSLSLVQGLKEKEKEKEKGHSMDSDSTIQTAMRTAKLSLTNANANTKSSQMQVSRVSKVSSAYAHAGEASNVGRGRSGTGARAGAGARVGVGARAGGNKPGAGAGTGIGEIPPGVKFTYKGHVELVDLEVVLPMPMPMPKRPRPAGLGRRPSSFPAGFPGAVKAEGKDKDKEGQEGVGEGEPVQVPRKTSSAFSHSSSSSGTRTPRPGPTPTPRLESESDSPFMSAPVPATTTYASPSASASGSPVPTPAPAFPQTQTQTPTQTQAQSQSQTQTQSQSQSQTQTQSQSHSQFTQTQTGTLRHSPDLCRFDVLSPSISFTLYAASMAERDEWVEKIREAKMGRMEELVGGRGWEVGGDEKEKEKEREREDITANSNAPHPHPHPHTHFRPSPSLRPHSYASGSGSASGSASNRTSFNFNTNSTTDTTNSNSVESLPTSFGSGSGSGSPVSHVSSPSRPVSGVGVGVGVGVGVSLGGVPGNGNGNGNGNGKGLGITAASRHQHQHQLVEDVLGDSTLGRSEGGRHVRRRFVAGAVPWGEYVEQEQGQGQGQGQGRVKVRGSENESENENENEVEEQMQAQEVQEGGKAKVRDGHGKKGLKAKLGMSSKDKDKDKLQSNSSSSKNHSTPQTLKKPTSTKPKSKAKTPRRALVEHFVPAIWIPDEKAEGCMRCGRQFGFLAGLGWGARRHHCRLCGRCVCSGCSEKTFYITDLSAKDPASSSKPARACNECFESVFPVLESDTGVVSESEVDADGDEDKDGDDEGEGGEGDGNGDNEDTIRARPRASRTFSQSSVPSSIPSFTDLPHHPHSPSHPQPDSSQLPISNRSPTPSPSLVTEIATVPVLVKEREKEREKKGNTKDKSKSKSSPSSSATDASPSKTSVYSNANLSNANVTANTESILRTYADTITSMTTSLLAISSPVYPSPSSGLPYDLARPGGMRSRTESTPNGHGYSYTQVPGIGLGQGHGKGRRQRHQQLSTAEALMAIDTSPLPLAARKRASFAGFGQNVKRASMASLGSAKSAGSGSGSGSGFRREREEEPGRKSREIVLDESGDEYHEHDLEGREAYETSLSQSVSLGLLGVGGRRDKRGSESSVGATAKEEGDVWVAGEEPSLSPRRSRIRMRPVSSRPRSYIAILEDFQSQGQDQADSQDQDASSLTTTSTSASPSTRIDVGAALEVPLESDEENDEGDYIDEDEEDESPSTLASAGALGPGSGSKSNPNSRFGYSKHHPHYPHAHSPGYPHGAINFGARKEDTIRRRKRFSLPAVALQTTSVVTRTQAPTTSSAKNNRNSNASASNASKRLSVPGMPANGAGASRLTPTSPSSRYQGMPVGKNTKRFSLVLGKGSQAQEPGKGKELEQGVNEESNDLAGSSAEDSELDRHEGKRTLARGAAASKLSELLGKARMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL42</accession>
    <name>A0A8H5LL42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL42"/>
    <dbReference type="OrthoDB" id="3248740at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="36856" checksum="3762AE16FAF0278B" modified="2022-01-19" version="1">MSTQQSYPLNSFDVYLLRSWLVEIAVPWLLYGINAMLLLFLSYILLSQQNHPTKPQLILLILVVFMLILSTACVTLETQFTLEQLPFLSEGLTDAKFDYIVHKSAHIRIALGVLGRTNYIIGDGIVVWRAWIMFPYNQLVKNILILCMLASFVGTFADAGLAAASFQRLQLGSTTNDLIMAIPLLVTNIIATGLNGYKAYLHNKDIREHLSQCDTHVTKAQKILLLLVESGMVYCGIWIATICVLAAANEAKVELTLAYLIFFTSLPFLSALYPILIILLVALERSKEDIRSMNEMSLSQSIRFASAQPAASQSESQREPRLSFNTSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LN13</accession>
    <name>A0A8H5LN13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LN13"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5363217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="26960" checksum="9AC4DC82F0968EC9" modified="2022-01-19" version="1">MAPGFLIVYSEPGKEVSLHEFQDWYNNEHVPLRLNHLSSFLSGARYSASDSKTPAWVALYDIDNTATFSHESYTRLRANRSPREAALVKKLELLDRRTCEGHTDSGESSLSSSLKSENPTKYLVTHGIAWDGDAESEKVAKEWAETSVTESKKTEGWVRTRTFKVIDSLKTGLGISEGPEAQKVPIYFAVQEFLTAESAESYAKQLAGSTNNLPKVSIAEIRVWSLYRAYPGVGQGNLHVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPU8</accession>
    <name>A0A8H5LPU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008194</name>
        <name evidence="7" type="ORF">D9758_018693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000296">
        <property type="protein sequence ID" value="KAF5332969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPU8"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF199">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5332969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5364986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="42095" checksum="107689C197611CC8" modified="2022-01-19" version="1">MAADIVKGGWSQEEDECLIKAIEKYGTKWSMVSSMVKTRNSDQCAKRWTDTLNPSIDRTSWTLEEDALLLKAVQEQGNVWTKIVKTYFPGRTGLAAKNRYNSIIRFTTDSRVARRKTSSTRKPRRISDPPSTLSESVASPSTSESSLFPDEPSPTPSGISTPSPLSPCELSPDLNSLWPPSNDVATEKPAQEQLFPSLQNEQYGIVQSQSSVLPQFDPSAVSFATSSTCNFLSQDWVSDASPLQDPFFPNTPYSHDFVDSMLQNSGSEWQNHGNLTAMSGHVDSGTYMNSEFPSTDQNALLSLLPPNLKDSVDGMTTIVHSPTSLCQPQSFDGQIRASMHSLLSDAKGALGPRHKQDQSHVLASLLNRMENESGRTPICIILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR66</accession>
    <name>A0A8H5LR66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000023">
        <property type="protein sequence ID" value="KAF5366396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR66"/>
    <dbReference type="OrthoDB" id="3252425at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="715"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5366396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="756" mass="84929" checksum="765C3896F9579B39" modified="2022-01-19" version="1">MAFSAGCTCKRITGVAQLLPRPTSTIRLIIYSFNEAQVRLIALWFRPTFPVAFCNLSPVACGHNVRRGDSDPFELLKDSNSESSSAHSLASIASTNIVKVVKGATSKVRNVVQKAKRSVKRRRHSGQASEPIEVLDSGHSDTEESAKEENDEDELERLPSMRSLVKNQASSMKTVASTTTSSARPPSARARVESDVTLMAVINTIYSMFAGLGNRVVSISHRMHTDPERRAAVVRWITESVRPLHIVEDRKLRELMLSGRPQASFPRRKRVAEDIKTAFEHCSERIVTLLKEYPGQISYATDAWTSPNHRAFVAWTVHLQHQGKPLVFLLDIIEVPESHTGEVLAREFDKMLERHGLQQKILGFCGDNATSNDTQMTALDSSTSNSFSVEGRVHCLNHTMNLAAKALLNGIAGSDDGAEGKLPDDELEDEEEEEEEEDLPTLLDNNDILPEREDDEGVDELEGIDDDERATFDWESAEVRAALEKIRGLSFSLIHSTTIGLPQWRAACICNHLPNRIIPRDVRTRWNSTFDMLEFVLKYQKAVDDITGNKDLPYRKHELTSVEWQVLKDLCYVLQATFLVNNTPPSLASQPLHSSVKAALRLAKKLMNRYYSRTDESSIYRISMVLHPGLKLEYFRRHKWQQPWINQAEQLTRNAYNEYVARSQSQQAIEETPTTAATLSTSSSPTLSAAAQTSQVNDFMNISVTSSSTVTACDELVDYLAMPLENVTDPLMWWWEKRTVFPILSQMALDYHSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU80</accession>
    <name>A0A8H5LU80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU80"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12087" checksum="107997936121AD1E" modified="2022-01-19" version="1">MLTATRRIFSTTLQARRFSASVLVSNANTSSSSPDVTEGERNIHAKLTEKFAPSQLQVQDISGGCGSFYAITISSQAFKGLPIVKQHKLVTQTLKEEIEGIHGLQIKTIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVB7</accession>
    <name>A0A8H5LVB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVB7"/>
    <dbReference type="OrthoDB" id="3254377at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="841" mass="88916" checksum="17FF2DCE9FAABE94" modified="2022-01-19" version="1">MQSFPASPRRTHRKRASALRLSSDTTATLPEYIPTGGWDRDPETPSDLPPEYTDSAEEADEDTDDTLDHSKRSPYVAQFTGLHSPRSARPKRHRRKPSSPSTSDLYLDSLLERSVHALEMSNALLQSSMSTQNTLSNVFSAGSPSDSTLEVRARGLSSRITNDRDMHEVWADDLAEIGRDVERLFGDGSPEEQPMRTRKESSTGSISSSVPLSAAPIGHYRRRPSLDFRSTAPEAPHLRYDTQERPQLVAHPPRALTQYVVVDANGEPDPGIVLPSTLGLRSAASHHAAPSSPIVTDKLPEPSTRAYNMLSSFVTRSNSSSSSKRPSRRGSNSSSAGQASSTSSRRQSKRNSPERSMSISRSTSSRSSSQSRRSKSATSNLSPYAGPSGSSSSSSLTITSSNNNRPNSSNSNVNGSPHRSHSPYYTNLPHTHSHPHSHSHSHSHNHPRPMTPPQEESSSSSSDACHAKQTISALRKILDEQPPPPPKKPRPSPALMKVRTAQPIEAGTSTATASISRLFTKPTHTSSTRPPSPPRVSSMKGKGRLDGEGHSRGGSLSLPVSLNGSRASPVEVEGGEQSQSALSTPGASTSTFLTVKTTVPTPAPASTSATGLPTPSSMSFSDMFGAVSAALSNSNGGSGSVPRTPNTPMSPTSATPSGMSTPKRISFMDPVDGRIRASGRNGKGRGRTLIDSLMGMGIGVGSGNGDKDKDQDKDKDKDNGDSATGSGSGTSSTKRRRKNADGSGNGSVSRNRKNSRKSGHRRHGSGSGSISSRDENSRESWWMGWLMGASGAYGPAPGTGSGSTMRPGLETRGFGSAYGSGSGSGSGRLSGYSSGLDDWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVW7</accession>
    <name>A0A8H5LVW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVW7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5371271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="456" mass="48716" checksum="926960074526DA8C" modified="2022-01-19" version="1">MTTDVFKLSLDKDTYKGTVSVSTGLFIDGKFVKPVEGGTIDVLNPATGKVITTVSGGSDKDVDLAVDAATKAYKTSWGLKVPGSTRGQMLLKLASLVEQNIEEFAALESMNNGKIFPSTKAEVTNAVALFRYYAGWADKVHGKTIETTENKMAYTRHEPFGAVAAIIPWNSPFYMLSFKIGPALATGNTIVLKPSEITPLTALKFAGLVNEAGFPPGVVNIVNGYGSTVGAALASHPLIRKIAFTGSTLTGRKILEASAKSNLKVVSLELGGKSPVVVFDDADVEQAVKWIAGGIFNNMGQTCIAGSRIFVQEGVYDSFVKGLADYARNMQTQTGDPFAKGTVHGPQISETQFKRVMSYISSGKSDGANVVVGGEQHGSEGFFIKPTLFTECTQDMKFVKEEIFGPVAAVMRFKSEEEVLEKANDTTYGLGAGVFTQNSSRAIRVAHAFEAGSTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW30</accession>
    <name>A0A8H5LW30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW30"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034016282" description="Tail specific protease domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="73558" checksum="B3382A3782EEE253" modified="2022-01-19" version="1">MVHTGNLLATLSALGYALASEAMLETRQNDPCAKIGGQQWVNPADLRACFTSFPLDPALQENIIDVLNKTMAFHVSVNYQISAPEPFTNDVHEDLLKDFARIKAQSYDSEYDMHVDIQNSINRLRDGHCFWSYNCFDCAFVYTNFLPIFLVQIVDASGTQTVNIAAESYNVSSVEFADQIDVWEAALPDGITLESLNGATVLSIDGKDPLIAADTNAETNGHLQGLGTRQNVFFASYQRGQTGWNYVLGDFAQQSLPRSDSVTLEIQRVNQPKTETVTIPYRARRGINPANLTDTASWRAGFCLNPTSDTFIKSYPDTKITREITKKFQQQSPMPPASFRDIVSAVPNDLTDAAFPPSLAPPAQNLPGEFGFGEFFMLEDGVTGVLAFGSFAGDTLEAQERGLLDGLNGLKSKGAKQLIVDVTNNGGGSVCIAHFLHRILVGPKDTTVPQAILDTKIRAGPLAKLIVKAIIENNTDPDVQALFNPARWTNASDVPFAPNFDFMDPAVDEVINGVPDAFSQRIGAECPDSGGWDVELPDEPLFEGPNVVIVSNGLCASSCGLFSIPMVKREGARTVVVGGRQGVNQQYTGTVGGQSLNGFNMFAEALNAGLVDNPLNQPILLVQGLIGITWRSAFGIDDPTQPEEWQDHSADLNLPLTAETVNNPLAIWNEVAKRMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWR0</accession>
    <name>A0A8H5LWR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWR0"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="561"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="637"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="684"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="729"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="772"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="815"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="858"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="903"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="127528" checksum="02687E8249387DD0" modified="2022-01-19" version="1">MQMFTNASNFQMENTTVTNIGRDQVNVTNNYYNESGLALQEKKLQPIMNTVRKKDICMNGTRVQLLKDLSDWVLQPDSRVAIAVSLAEQLRKMNDQVILALTFHCVKGQDTSKESPLKFKDDTSLNANGLPLQEQFNAFLDVSLLNFSTGRKVVIIIDGLDEWETSIQWKILSQSLVATSLQVPWLRVIITSCPQVELDKSPNANIAVKSFNLMEQYKSDVDIQMFFQERLNEPGIQNFADSDTKKLVAKAGGLFIWATTALTFIQDDVDEERNLQLILGLPGQDVEGNNPYTELYTLYQSILKQCFKSTKSQKLFRDIVGVLLAVEEPISTSVLVELLQSLKISVEKVLHILKALKLYYHLSLKEFLSSSSTSDDFHVQLLVQNCVGILVKELRFNICGLELSTVKNTDVQNPSLSDRIQSNIRAHLQYSCMYWTTHLANGGDISGEIVGRIEMLMNGKWLIYWIECMSLVDRIHKLKENISSSIQNKNVEDLADKASKLINTFSVQLNESTPHLYVSALAMVSQLDWFGDYIKKRVHIENFHLSSHLLTINTACRANNVAYSPDGKHVVSGSDDITVRMWDIYTARQVGEALQGHIQRVYSVAYSPDEKYVVSGSANITVRVWNTDTGQQVGEPLQGHTDWANSVAYSPDGKHVVSGSCDKTVRIWNSETGQQMGQPLGQPLHGHTGIVWSVAWSPDGKDVVSGSEDQTIRIWHTETALQGKDGEVLQGHTKSVMSVAYSPDGKDVVSGSSDYTVRIWDTETGKEVGEPFQGHTDSVYSVAYSPDGKHMVSGSLDNTVRIWDSENGQQVEEPLQGHTDWVMSVGYSPDGKHIGSGSDDRTVRIWNIETRKQKGNQIQGHTDRVLSVAYSSDKKHVVSGCDDTTVRIWDTDTAHKNMGHCDWTANGKHVVSGSDDKTVRIWDTVTGQQVGKQLQGHDETVWSVAYCPDGKHVVSGSTDNTVRIWKWHVVSGSSDNTVRILDTEEVDGKYVVSGSDDQTIRLWDTETGQQVGYPMQGHTDWVSAVAYSPDGKHMMSGSGDCTIRIWDTQVEPTFPKIQDIPPSYAHSPPDEPCHINEQGWLCTKDQQSKLILWLPPNFHGIDCRQVLTIPSNTANFSFKVDWSNFAYGQNWTQVWEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B5B6</accession>
    <name>A0A8H5B5B6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_017993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000487">
        <property type="protein sequence ID" value="KAF5316845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B5B6"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5316845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23851" checksum="1B872462E4D42CE5" modified="2022-01-19" version="1">MADALPFILILSITLLIYYFSRRSALPKPPGPRGWPILGNIFENPVSHKQRKYKEWGDKYGPIVRYSLFTDEIIVLNTRETATELLEKRSASSQDRPRQIMCGELMNWNKAMGLSRAGYQHRTYRKLVGGVLSPTAVRNLFPVEERAARLFVHDLLRQCSAGFDGEKRRPDQALAVAQTKRWQECCRNHFGADFAPEGRTGQGLTLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BI72</accession>
    <name>A0A8H5BI72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000393">
        <property type="protein sequence ID" value="KAF5323634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BI72"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5323634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56580" checksum="78638B9141E810D1" modified="2022-01-19" version="1">MTERRSASADPKLRCANRPHVFHPASNQDACYIPENGDDPWVPCKAQPCLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTNQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLAQFNNYLRMNKGRYPTEESQVSLFLSFFTGEKGGDWATQRLTERDADEEDEELTDTPDQRRWITLKEIRDRFKRDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWKNFDQYQERAVELHLEWLKERERQGRWKTTSTSKNSPGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPSRTIRTTETASPPLVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BSW0</accession>
    <name>A0A8H5BSW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_014247</name>
        <name evidence="6" type="ORF">D9758_017025</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000362">
        <property type="protein sequence ID" value="KAF5328471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BSW0"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5328471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5338040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="233" mass="25869" checksum="AA6CD7A76B235B20" modified="2022-01-19" version="1">MSSALSLFVVSPDTRSERRIDPHITVEQLKSKLELITGIPAANQSISLLNSEDDPRVVDQLSDDSKALGFYGLRNFQVLKVDDLNPSVSFTGQLTDVSQVDKFEMSDADYAMRQDSVLSYKQRHKVGRFAPKTDASKETENVEIPIGSRCEVESNEPGLSKRGTVKFVGQTKFGSGGGIWVGVEYDEPFGKNDGSVQGERYFACKPNYGVFVRPDKLKVGDYPELELDLDEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C120</accession>
    <name>A0A8H5C120_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_014580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C120"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5332032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="232" mass="25392" checksum="00615376FD29F250" modified="2022-01-19" version="1">MPVPALTVSALTKHTATVIFVHGLGDSGHGWKPVADLFQADPAFGHIKWVFPHAPERAVTANMGMVMPSWFDIKSFAFRAAEDEEGMMETVKTLTQVVRKEMEYGIPPNRIVLGGFSQGAAMSLLTGLTQDLDLRGVVTLSGWVPLKHRFKGLSSAALDTSIFFGQGFNDPIVKMPLVRESLDTLRDAGFTINNDVVKSTDISYNVYNGAGHSTVPAELEDLKKWLKHVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C6Q2</accession>
    <name>A0A8H5C6Q2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C6Q2"/>
    <dbReference type="OrthoDB" id="2970175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6699" evidence="3">
        <location>
            <begin position="368"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5336242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="517" mass="58480" checksum="B56B3E4324020620" modified="2022-01-19" version="1">MPITHLYLPHTLLFHICSGFHILRFLLSVLLFSTTFYDMYKTSGGFPRTPKIPNQVLPPSPSPVYTATTTRPHYNYGSFTAPTTSIPLRSTTPSPEYYRPRRDSSSSRSHDTTNTRMRRNSGPSDTKPLKSILKKTVDSVINTFRSSSRVETTRPLANGPRLRLALRAFLTIVLYTSRKLFSDEGSYSSTGTSSDASSFDNGRSTDVLIYRSRSRDHSTTRSTEDHLMKPHRSSSRKDYPAVPPKHRSVTSSDSGAASDYEVMKVHRKHHHSSHHSSKSRSSGTSSSDSGHMSDSTPNFKVKAIYANKPPGGHRYPLTPNTHPPRSRLSKGCGEEWENSSKHEAISLMWPLVGERLNHKGHVQACPLYFDVAFEPWYNVSIWSATEKRARKFFPAQQECPASPRTLLTEMTIFCDMMDMWPVRVVRKEGIRCLDVFDAIYRTYAVPVTDKEKQILGPEVILRSEAAFSQRIRDGPGLPYVNERLGVLRVDTLANYRIFGGLVQNGEDWKLILKDPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C994</accession>
    <name>A0A8H5C994_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_013587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000217">
        <property type="protein sequence ID" value="KAF5337475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C994"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="297"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5337475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="529" mass="57380" checksum="FE5CDD25BB168BC4" modified="2022-01-19" version="1">MIEDPKCLNSYNVAQLQYALAHPKVLVDDLSPSASPPIIPTDIDYGDRRMSSSATSTTTDTDSSVGQKRPITPEDDLKKDVDDSKVQLPSIFTTFEDGPRPLADYRRASLPTLHSESRVRHAPYPSPAQRQSYAHSNLSSYTFPPTSEEPDEKRPRLASDVSYSFDSSNYSLPSHYDSSSAGLAPYSTDSSDSWNSSPSGIVRPNSTPGQLSSPAVKYDESLRHAPFNASTQAQIFAGSARISGHQDRRSSIKSEWSFPNQDYILPPYPSSMSPASSSPSSRSPQAVPAPSSLVDRPQRKRGKLPKETTDFLKAWLHRHSDHPYPSEEEKKQLCHATGLSMSQVSNWMINARRRILAPARPSTGPTTTAPFPPTGRSASLSGLLDPLSRRASLPAGGPDSLQLYHPMSMQPLPPSDYRMYPRSHQHQMGPGAPGHLDYQSQSRGLNMYPPQQQYPMNASVPLSAPPSLSNNPFSSPGSHTQSMYPNGGNYLRAHSGGPGSAPGGQDSQHYYGDGTSNGSAPGSGYATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9Z3</accession>
    <name>A0A8H5C9Z3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_015076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000224">
        <property type="protein sequence ID" value="KAF5336712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="513"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="11">
        <location>
            <begin position="900"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="12">
        <location>
            <begin position="1499"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1311"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5336712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1742" mass="193306" checksum="D96B6106B8AFFFCC" modified="2022-01-19" version="1">MVSVISAYPAAGVIVPQPEEPPDPNGLTPAQAYQAQVYLNSPQNHYQQDWQRFPHQSQPHLPPQRSVSPQSHYSQNGPSLPPQIPVSFDNSDSGFGIDFSNPSIDVPAFAHTNNHPDPPFEDTSELPWARQDPTPAAPLVPPLRQQSRQPSPANGPPPNRFSAASDSAGPHPLHIDTTTAQSIRSSVASTSPSSFTMVDHASINTDYSSTLSGRRSSESAHVPTRILNGPRQRTSDRSMSMSAATNSIRASLANRPPIPSVIEGGRNSPVSIRTTTRKTPIVYPALLSRVADAFRDRIQLTDRVKDGLTYTDSFDGREAVDKIAYIIKTTDRNLALLLGRALDAQKFFHDVTYDHRLRDSANELYQFRTKLPSPFVSGELPNMDAPKIPSLPTEPAEADDENSPSPSISIPPVLPPRRERKDSISSDEVELPSGVFTLLTDCYSPTCSRDQLCYSIACPRRLEQQARLNMKPQAVLKKQISKESLGDTPEDGSLWIHSVPPEIANSVSDKEKRRQEAINEVIYTERDFVRDMEYLRDVWIKRLQEEDVIPEDRRTTFLEQVFWNIFDIIAVNTRLRDALIKRQKQYAVVEKIGDILMDAVPHFGPFVSYGAHQLYGKYEFEKEKSSNPAFAQFVETTERLPESRKLELNAYLTKPTTRLARYPLLLGAVLKHTPDDSPDKTMLDKVIKEVREFLAKVNTESGKTENRFNLIQLDQQLVFRPGEEVNLRLREEGREMIYKGTLNKRDGELHVYLFDHALLFTKLVKTKHHEQFKVYRRPIPLELLYITASDDAHTQNGNGNGTIRARHRQGLVKKNSFNRDSRNAGPVAPPINVKPDHAKGQFWINFIHLGRKYYNLVLWANSALSQKKWLETIFKQQQSMRDRSTIFETVPLSEGFFLMSNKVNCAAPFHRYHLTDDVVCKDGGNKVAYGTDDGVYISNLGQVNKDPIKVLALVDVAQIDVLEEYQLLIVLSERQVITFPLDALDSMDPTAGLKRAKRISSHTSFFKAGYCLGRMLVCIVKSSQLSSTFKTLEPIAQDIRGQRKPTFKKLLQGGNDTLKLFREFYIPVESTSIHYLKTKMCIGCSRGFEIVDLETLDTQGLLDPNDESLEFHPLLSGCQYDTDETIEFAFYINKTGRRSRKDFMVHWEGVPTGFALREPFVLAFEPSFVEIRHIETGLMTQVIQGSNLRLLFAENPPSMSNGNGYYNTYQQPGYDPYSSQYSSYGGRLSGGYGQHMPYQMQQYGRPGPPGYNRDEILMVSDDRVLALRTQQRTIPDNMSMCKGLYIAWRSMDPWQFDCLPWEECKTAAVNASPNQQRHHNIAKRQAPPTTSSSASSTSSTTSTSTPGAPPAGSSTSTVSAATGSTTSGAAVPTTPNTNPATTLSATQSDVPPLVSIKVGMPSGTTYALTTAYAPGATPSYSHAPPLPSASFAFNAADWPAQDKVPDTNSAQVQEWMKELDGWTIPNIPPTADGTCVGDPVAANEAQSRGWWTCGGWTKPTDIVACPDKLTWGVSKLLKYLDEKDISATFFVVGSRVIERPAILIDEYMSGHEISVHTWSHPHLTTLTNEQIVAELGWARKAIKTVLGVTPTTMRPPYGDMDWEVAGGLIDAPTQYQSFENILGNATTIDTGFIVLQHDLFEITVDLAVGYTLNAALTHNPAFKLEPIGQCSKIPTSNLYRESNTNTTFPFSNSTTVDVDGDGNSESLNGAAGNNGKNAAASHSVSLYSALSLAGLAVLAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBM1</accession>
    <name>A0A8H5CBM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000200">
        <property type="protein sequence ID" value="KAF5338131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBM1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="10947" checksum="B0C910A33AB36F7E" modified="2022-01-19" version="1">MVVDVGCRFMVTPSFTHLFIHLLHVPASYLKTAGTSPSPSASRPTSRSLSVVGEGLGLGVDSLGSSGHLGLKYVATLGLLVFSPSLSYSSRQALEPHPNRLNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBY0</accession>
    <name>A0A8H5CBY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000197">
        <property type="protein sequence ID" value="KAF5338296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBY0"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="205"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="484" mass="55610" checksum="931F1D27942A0345" modified="2022-01-19" version="1">MDLLSSLTQEWPKVTFGAISLLSYMTLVRCLRWKRYSSIHRQYQPSYQRNGTLIPEEAQKVVVTALQYDMPLLLNYSLAFALFKTYAIAHYRLTYHASTTPSQSSISKILMSTKELSSREGISKRYADTEILIASWVACPINGKVYMDSTGDHGLNCTRRMEASSTDIDAPSTINVSQKAEKHGQDDPRAMIALARVNWLHSKYPIKNEDYLYTLGLFAFEQERWAKLYGWRKLSELEAHAIFVFWMEIGRRMGIKDIPETAEAFKKWIKVGGYLNFLTFITVLFDSFHFIQEYESTALYPSKVNHDVAQFTLDELLYAVPSAFGMKEFARKVAISLLEAGTREGMMYPPQPAYLRLFATSILHTVNFIQKHFCLPRATPRFPVHRELPDFAKNWDGNAQINKSTSKSGTKANATLYRMHPQWYQPQPWYKPESTTFLGQLSDWMLVKLEEMGPLKFEKSGNDEVIEMAERLQGSPIAGPWARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHG9</accession>
    <name>A0A8H5CHG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000165">
        <property type="protein sequence ID" value="KAF5341364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHG9"/>
    <dbReference type="OrthoDB" id="2687560at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="735" mass="78191" checksum="8BF28451E5B15B93" modified="2022-01-19" version="1">MHREWNPRKVRSLRAFSVPNLKLLPANRPLFHCRRCHFSNDRYHICLFCGWTSQDAEDDFQCKIQRRTLSSPYRLEFFSLHRRVQVHIPSQSVARSPESLQSIPNPIPTLVADGVALSCEGASPSLCHDYIPRTQTAPDNDNDTSGNTTIPAILPTPSHKGHARALDCQSGCRLDAEVEEAVVTATLVPIPVSVPTSTSSSGSSPVLALAATRAAVCQDDYDSSYDVDSTPSKETSIPRPEEQVSRFSNVHFSDSVDRSSTSTSLSSTSVDMTFTTTSTMNPHSATALRILADVSNSNHSVHSEIAAAPSHPDSNPCASSSNLTAASSSAQRALRHKKRQAMLHFSAPTPPSSGEANAGPSIGNKSSSSTMNTVRTTNTIRPQSHPHTQLSSASAGTVMSSDSSASIPITRIPVHSRSQSQPNVNLVLGNKERPYYSAIRKDMAITSASAVMPASLPTSTSSSIEDSSTYDVSSPSSRSSSTPPSTLVQPTSTSAAASRSAFSFSSSFSPTSSSSTGSRAHSPTSHPHSHPIFTPNPGSSRIPIPSFPSSPLPSPSPYLSPSSSSSTPWSSSSLSSSREPGSFGRPSTASRPSTSSRLSFATTSNTTSNTRPSLDSTRSVSPTPAWLFDSSITNINLKDIDNADDAELPTPVFSPPSQSPFPFLSPFSSLPTPWNVFACDCDGDDFCFCICVSAVFTIGSDKVSCAYPFGVSKTYDPILLVSASAFIFTCQDLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJV1</accession>
    <name>A0A8H5CJV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJV1"/>
    <dbReference type="OrthoDB" id="3251367at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="728" mass="79465" checksum="2196D333215322E1" modified="2022-01-19" version="1">MSRSRDTYAALESGSADSLPSTPQRNSRPTSQSGQARLQLNTSMISGPILPTAPQSITGFDDVEGRWIPREHRSDNSIQGYPSSPSKSSTSSRSGPSAIAWLRPPPQSPASSESGEQMSQPDALSAPTRAALRSRYLHGMDRSLSSPEASSSTTTTTPTSLSPSPLPSSSSSSSPSSQRSARPTALSLHSLRLDAQSQSGYNKHAYTNVYPNSLHAGQFLFPQSRTLRYRSPSGSKKSKGSDSSDVTIRPSPVHSTNPFISRTPKRSLSQSSSRSASSVAPSIPPLDLRPPFPGPHPSPSYDPPLRPPKFSALQLQTQLSTIEASGSSEEYDATPTEGEYSRASAHADSFVTASESSPHPLRAGTSMIQFGEPQIMEVDREHYDEEAEDDIGLAIPVAYLVGDHPVEYNDAVGALLQSSDSNTALSGNPSSTHRLSTPLSTHGHLAANAYTHSRSYSTSLTYTTGASQSTSESFLDRRWERDAGFSAGSALGSVRFKRPRREWVYTTPAFWAFWLGFVCPVLWLVGGWHFTRYGEMPPMKTVWEFYFVGIFKVRFGMGIGRKEWWDERMGWCLGKRRKRADGGNGKEKEKENARDASENGSTNGIPPGGGVIGNPVGDGDLEKGYGRHPRQPKRQHQQSLPPLPRWIQEKQSTESKIFKRSLRGISFGYPFIPRPPPISSSPPSSSDPGPSAMQKCGQIFMAIITKPNRLFDLFSCRQVEGRPWKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK73</accession>
    <name>A0A8H5CK73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_013415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK73"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5343230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="836" mass="89805" checksum="CFF6B05CE0AAA2CF" modified="2022-01-19" version="1">MANHDKQVPRPYKCPYPLCGRAFSRLEHQTRHIRTHTGEKPFVCNFPGCEKRFSRSDELTRHSRIHSNDPSSSKKPKATQQAKKKARSRANSDDEGESYARPTSFGSADSRRVLPSSSASQPQPSPFTTLSTVAMDQLYALERAEALPQPSPTCFQFYNDTARLTKSATTSPVSTPLYGPTAESSYFGVSNERDRDTEEGDDADEIRDRGRRRVSGPAWYMTPMSAASASSSSAALSTSRSTGHIVSHGREHVHRDFYAHAHAPYPYPPSRPHSRPHSPHREADRLHSHLHSQSHGTLPYPHPHHHRMHRTRSVSPASSDSEGEHMSMRRSKSRPRARSSGMPPPMSLTHPSGKLVRSTPGTPGGPDFSPLSSALPSGTTSTQLNTPAYTPSTSPFLGPLKGLNLQSAAPSANPSRAGSPVLMLPLPLMDCDEKSPTGSPPHSFRDRRHQHQHHGHLYQHSHGHQPYTTHFERHGLVHGKERERHERESPVMGIPTPASSTSNSNSGSPVGLRQVNGLPSASLLRSQEGSRAPSPSHSSGHHAHQNHHHLAHSVRMAFGMTPIHPQPQHASAAHSSSSSHQHVSHPLHSNTYPAYSSSNSRYNFGIGPGSSASHAFGVASHPVSRSSSPPITLAPLKLRVDDDEVEMKVEETDRVVPKDVGRGSVLQGSSTTSCSRPGSRPHSPLHTLTPTSNSATTSKSTSPALANVLSGDSSQHLSGSPSKSKKSSVELPSFKVFEAAARGEISSFGEYPHAHHSSASSHTHSGASSNANSAAVKFVGSVGPPVSPVPVSPISVSSLACAPGFLRDGEEGSEAGPPISPLSSEDSPQMSVNVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKK4</accession>
    <name>A0A8H5CKK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKK4"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="2">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="131" mass="15100" checksum="8485C84437F7E00C" modified="2022-01-19" version="1">MDDQGQTATSPLNTKPQTPHVQIPHNVQTPHPAKEIRISTPTPFEGDRKKTMQFMADVVLYLGCNQEIYDTDKKKISFALSYLKGRSAADWKLIRVQKYMKNGWPDWDKFLGEFNETFSPINEQGDAWIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLL9</accession>
    <name>A0A8H5CLL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5343980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLL9"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39360" checksum="D452AA92E4420A3E" modified="2022-01-19" version="1">MCRLPVEILTENFKWRCGRSHLTIGGELNEGTDRFEQSVKTPTLDIAQTCSLWHNIVLSRPSLWTRIEVDLNCDRQSESLVDLVTLYLSRSSPRELTLTIEAWENDGNADSLTETGLSMLLALVKEKHRWKAVEFSLSISVFDGLNFAGECRRSCDCLEELTLPDEMDAMDNDRTRTKFAIDAFHEMLYHTPELHTLKIKGQFSEHLIGTGVFDVRTFILDIRGNELDLDNVFTLLAMYRFLGSLDILPDFDHEPEIPLPPALPNGVSVIDSPLQHLSITVRDDSDSECRGLIASAYLFQYLRARELKDLWIRGTNLKDPADSEERDICFNSLTKFLRAPSASCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM00</accession>
    <name>A0A8H5CM00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM00"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5344271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="27515" checksum="43377484198F3F47" modified="2022-01-19" version="1">MLHRLRLPNAPTQLGASNLRARGRIIASASLILPQLFLSDYSTALDVKELSRLGITHVLSVVGFEPGIPDTVPVLVSTSSDNTKPTSSAQQSTASSRRTLKKLHIALEDTPQANLLGRLEETTEWIKKAIEESKDNKVLVHCLQGVSRSSTVVCAYLIANADMNPSQAVKFVQSKRSVVLPNSGFRKQLDEFGLRFIGNRQIRTKTDAGAGDTAKRPSWCAPASWGISEGIRERIESLTLERHSMKGTEAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNA9</accession>
    <name>A0A8H5CNA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5344026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNA9"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33063" checksum="50B1783ACD2B9A49" modified="2022-01-19" version="1">MSTNVVDNNTQSQTPMDKINLDLTELDAHELALLQSQTGIQDIDELKRHVEDVAERAFKARSKFVYQPIYKHVLELGKTRKDAIFLDIGCALGHDTRKVVADGYPVQNVVASDLQPEFWTLGHELFKSTPETFPVPFIPGNALDEAFIPDCSPFDNASHPPSTEKPTQSILTSSKSLAPLQGHVSAIHVSALFHLFGESQQRVLARKIGSLLSPEPGSVIFGIQRGFATPGEHENPRGEMVFWHSVESWKKLWVGGEGEEGVYPKGMVEVDATLWDHKLGSQEPNRCFLVWSVKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNC7</accession>
    <name>A0A8H5CNC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000133">
        <property type="protein sequence ID" value="KAF5343807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNC7"/>
    <dbReference type="OrthoDB" id="3270319at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="124" mass="14009" checksum="09E89FF01CF0E770" modified="2022-01-19" version="1">MAVRFAKDPDAGYPDFKTMDEYIPVQSTKMTTTARICKHYLQDGHVDSVKFDNEAGVPRFPPVEPAEPGEKPPKILIYTEFLSLTPLLQKVLRLYGVESLAIDGSMSFKKRDKIVAQFRKSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQC0</accession>
    <name>A0A8H5CQC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQC0"/>
    <dbReference type="OrthoDB" id="3541472at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59767" checksum="AACA9FB1DEAFC860" modified="2022-01-19" version="1">MIGLIDLPTETLQTIAHEVGAGSWSNNIPQQLTPFRTVCKLLNSIVEPFLFSEIALNTHPGALSTTTIPFCKALCNRTDSASGEANNGLAIHVRNLKLRTYSTRPQGPCTDDGTVSESWQELLIHTLSSLINLRKIVWVLSQDTPDWMYAQIPLVLSKLPSFSVFEVNGDQGWLQSYPNLFPLDRLKNLQTLVIKADNLPNSGFDSCILRPLSIALKNSPALQELEINGPQPKMGEPTHSLHDLLENVTTTAPLKITKLSVQNLNMDIDPAFSSHLKCLTCVDVMNWRRNGKTGNFWTMLQKGNVCLEDLRVDSEIDGTLLKYLQEFHSGLKSLRLSGAASSFTDAESDEVAGLFYGSVLPKLAGNLHQLSVNPSYEGDWCFGLHNIEVFSKCLNLEHLNVCLKLREVDDLIVSTTLLVDSFVAFTDAITTPMLTAGKQIPLLNMAHSLPKLRGLSLSSADTTSNRGATCGNSSMSYHHNIMEKIHEALRNTTPAEAHANSALRISGFMRSYSVCREEDGSLKYRESSWFNGDIKVVPAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRZ5</accession>
    <name>A0A8H5CRZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_010130</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRZ5"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="607"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="388"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="301"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5346907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1206" mass="131732" checksum="E45B48240080CFE3" modified="2022-01-19" version="1">MPPKNKGKKSKKTQDDDFWENAGESVANNISTLAGDASDDDSKPSESKGGFSAFAALGGMDNDAGGAEEEEEDFGGLMSAIQASTKSKKDKKDKKKNRPTFDDLPPEEDGEAAESKKPVEMTAEELADEEWGPTKEKAKKGKKGKGKKGKAQQEEDEEEADEEAKTAKAEEPKTQDEEKAEPPAQEDDNAEQDGGEVKILSKKEKEKLKKEREKAKKKAQAAAKKVESASTADQATSSPAQAPEQAEKEDEGEEEAEVETGGKGDSKKKKKKKAKKDEDSTPAPAAAAPKKKGGISALKALMEEKKRLEEEARRAEEEERKRIEEEERKAAEEEKRKEEEKQRKKEKEKAKRELAKKEGRLLTKKQKEEKAAAEMRKKALLASGVQIEGLQQQAAGAPVSKKPVYGNRKKKGPAEKDASPAPESRPRSPEPASTPAQKAPEPEPEPEPPANSAEKDDWDASSEEEDSKPAEGVKDSWDASSDEEGTPAKKEAPAKDAKSAASSTATPAKTNGKPAPSKSTPAPSSKPTPAPSKPAAAKEESESEEESDEDSDEDSEEDSSEEDSDEESSDEEMSKAQQMAAQRKAEAAERRAKVHEAALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVEAIQTKTAVMNKDGSQEYKIPGLLIIDTPGHESFTNLRSRGSSLCNIAILVVDIMHGLEAQTLESLRLLRDRKTPFIVALNKIDRMYGWQPTPDGAFRESLAKQTRAVQREFEDRVSKTILAFAEEGLNAVLYYENKNFARNVSLVPTSAITGEGVPDMIMLLVNLTQQRMSDRLMYLSELECTVLEVKVIEGLGTTIDVVLSNGILREGDKIVVCGLNGPIVTQVRALLTPQPLRELRIKSAYVHHKEVKAALGVKITAPDLDKAIAGSRLLVVGPDDDEDDMKEEVMSDLTSLLNSIDKSGRGVCVQASTLGSLEALLDFLKSSKIPVSGINIGPVHKRDVMRAGTMLEKAKELACILCFDVPVDKDGERLAEEMGIRLFKADIIYHLFDKFTAYNQEITEAKRRDAAPQAVWPCRLKIIAAFCKRDPIILGVDILDGSLRVGTPLAVVKIDPTTQKKEIIDLGKVTSLEINHKAYDVVKKSQAGGGVAVKIEHAVYQSAKMFGRHFDEKDELLSHITRQSIDVLKASFKADVSNEEWLLIKALKPRFGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS23</accession>
    <name>A0A8H5CS23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS23"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5346952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="53468" checksum="BB5E796F4CB63E00" modified="2022-01-19" version="1">MTITAAVLAEICSALPLSGSIYIWAAESAGPKYARFFGFVVAWWSCTAWMTFTASNCQTTANYIVSQLVVWDVSFPGGISSSNVKWRAFIWAVSEALLLLSVLINRLPPKWYSMVFKFSVGLMMLDFFLCVIWLPIGVSRTYGFRSAGEVFTGTYNGTGAPPAWNWILSFLFTAGTMTGFDASGHIAEETKNASIVAGKGILTSAIATGVLGFITTILFLFCTPDLDTLFALEAPQPFVQIYAMALGKGPSVFMTIIAVIGLILFHENVDENVDVALCYLVQNTSIAIVAASRLIFAVARDGVLPMSSWIGTVTPNGQPQNAVTVIYIFGAILLCTILPSTVAFTSLVSAGAVPTIAAYGLIALLRLVMTPDRFLGSKMLLGKRMVRALFGWTGGEGEAGRGGGGRRGGGRWLAKLCYLSAAVFNALIVAVDVSPFFFPVDAENFNFACVIFGAVTIFGVLSWWFTPEEKWLRREVVLKALESDGDENADENAAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU32</accession>
    <name>A0A8H5CU32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU32"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="38530" checksum="3E15DCD287C87807" modified="2022-01-19" version="1">MSAVQVPYRQLGKSGLRVSVPILGTMSFATKEYYSWGVPEEEAMPILKHALDQGINTFDIANMYSNGETERIIGKFIKKYNIPRSEVIIMTKIMGIVGKEPGLKTAVMPQLADKREYVNETGLSRGAIFNAVDACLERLDTPYIDLLQIHRYDPKVPAEETMKALHDLVQSGKVRYLGSSSMRTWQFAHLNEVARHNGWTTFISMQPEYSLLYREEEREMFGYCNFHGIGIIPWAPLAVGALARPVGQGTARSETIKGTPFEKKLTESDNKIISRVEELSKKYNVPMATIALSWVGTKVVAPIVGASSEKRVSEALFVGAVTLTPEDIKYLEEPYEPRPTRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXK7</accession>
    <name>A0A8H5CXK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000079">
        <property type="protein sequence ID" value="KAF5349805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXK7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="167" mass="18539" checksum="F103422382837611" modified="2022-01-19" version="1">MAPVVDNPLKVIEELEFVWAVPLRAEASSPPPETVAPHILGEAQGNRVSGLGLWGMTSTCLSFWRERSGSLCMEEVGRRLATRDSEIISIRDDFATWRELIQERWGFQASRENCPKARTLKEGGVTTPLSMDGDIIEFSAVRWSTDDLAPLNVGVLPGDWNTQEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0Y4</accession>
    <name>A0A8H5D0Y4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0Y4"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36673" checksum="D73940657E867E8E" modified="2022-01-19" version="1">MSVSRPPLAPPTATSTPGSPIRPTDDQIVVLYVIIATSVVIFGFWNVPGIRNIINPLKLLTIGIHEFSHIIMALFTGGRILRITIDPHVGGATIVEGGIPTLILSAGYIGSSLFGGLFVLAGWDILVAKVMSFVIALGLIMPLTLVRDKLTILLTVLYEGLLIGFWFIDHGSALRWYCLVIGVMNTLFVVWDFADDRFFHKINDSDATQFSLLYPSMGPHDFNSNSPLTFTSGRFSVLGILAFKRTPDEIEILAYKMINHSQAINDVIEDGSIYTMLHDGRQDGQRVARYVGRNLTVRWVLRRERPIREGLGSLQAMIDEWTNDLRLSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1J5</accession>
    <name>A0A8H5D1J5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1J5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="540" mass="58364" checksum="E4E3B9807EF5AAB3" modified="2022-01-19" version="1">MALHVSNPHLVLQQARQRARSQTQIPSSTTPQHSDLAFRSPLPERPPRRNPGQLGLIGGRPILPNKLIEEDAKTAQDSKNLSVAPTSTRPLKIVKCPARKDLALSENPPLDFLKVPASNDRTKAVHLQDVYNRSRTKSAENLTPTRLQKKSGTPKSHRTISEKDLNLPYASPSFHSRARSVELDLSKKSPRHRHQSTSASIFVSTKLKIVSPTTPNQKSNTTHSYSKATLSPKAQIPTRSPSHLKSSSLGVRMLPSSFASISPPRSTRLTATTMSPTHRPHSTTSFRTPTFSQSTRPSCRSIFQSLVTSASGQDISSSDITTQNNKPRGNARRASEKPQSSMPKYKRHAIYTHSLNFGAEFSSLGGVDTTMPLSDGHDSGFTLPSKRETLPVSFSSSLRHKNDIVDSIAEERITEEKDPESQANATEPSFLSSSSSVLGLGPSVNVSALLVKADGFGDMESSFLQRQSSRSGSGSSNSCSLHSLCSQEALSVSVALSKPVSQDANANAAVASSLAHHPIALELLMLLDVCIQEWSGPGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1K4</accession>
    <name>A0A8H5D1K4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1K4"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="8">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5351513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="84" mass="9760" checksum="4D6C500B7B5AB6ED" modified="2022-01-19" version="1">MSDSLPEPQANVKPKDYRETFRSRQDATQFADPCEAASKASLACMTKNDFDRDKCLDYFQAYRDCKKTWMDQRKADRRAGRPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D228</accession>
    <name>A0A8H5D228_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D228"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="423"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5352065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="654" mass="71981" checksum="F222DA84AC8C95AB" modified="2022-01-19" version="1">MSFTDDKAHPSSSIGSFNHLSSANLSQNRINTVGRDLYETHHNYYQIIKDSKGWRIKTMGSILEIGQTVIQGIAGLLYGSGSSSSIETTTQESIETLEELFNGTDYRVHSARHKGRSVIVKVFHGPRAKEADIFVYSVMSLIQTRHPSMLRMMTCSPSSSQTPFIVFGDECERGSVDHCVASALTDGLPRTVMLGFQLIGGLSAGLDYLSTVVGVPLSTVGRDNYEVYITSGDQVKIGLGNCKTGRHGEDDSEADWVLFNDLCSKHTGLRVVCVPEEEDIDRNEASIAEDAEADGEPNSQFQPSPFVSSGSPDFPDILPSSTMITPRRELQWTRSPQVSTLSSVSRRYRDHLRMSPYRGALDLRRLNAKRRFEVIPHRCQGYRKEEITFTSEIKECAVVLHTMPFRGEICLICGEIVTEGVFRCICGQPDDGSSATIRCSNCHAWQHRTCVIDLSALAGQYTCLSCQQTHSEASSMEFVVPDETLTRPSSPSASRRNDDDRAASPVSSVSSASEPPLSARLKANGAPPVPRDRSLSPTETVDVREGPTTSEPPPASTATQDPPIAPASPTRSWPPQWLSSAMHSTQAKYPNDKFEFALGNRVSDNASRECLIKCVDCPGKLYKPGPGETLSNFEVHLKNRQHRQRVDDRVNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2L1</accession>
    <name>A0A8H5D2L1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2L1"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF4">
        <property type="entry name" value="BLR3030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034971294" description="CoA-transferase family III" evidence="3">
        <location>
            <begin position="17"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5351563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61048" checksum="217CFE33FB97692E" modified="2022-01-19" version="1">MLLSMSLVLWISVVFCSCNDTSIKRDKLFDIPKTCFINLFSLNRSMTSFDSNDELATAHLLWTTASLPEEYLGRLRLTPHPDCTVNSSFKLAEAAQTSIGLSALSAALFHDLRTGVKQDVSVDARLAVLEFRSESFYTLDRKAPGPIWDQIAGLYKTKDGRVRIHTNFPHHRHGILDLLKIPNTPAVTKAQVQDALLQWTSQDFERQAGEARMCAFALRSFEEWDQHPHAQALVGTPPVVIKRIGDAPRRQIEEGVQPSKHALEGIRVLDLSRVLAGPVAGRTLAAHGADDLLVTSPLLPALPDLDVDTSRGKRTTQLDLTHTEDSEKLKSLARDADVFLQAYRPGALEVKGFGVDELMKMEGKRKHGIVCANLCAWGWDGPWKDRRGFDSLVQTSTGFNVAEGQAYSAYLASIGQAADPEPRPFPMQALDHTAGYLLAFGINAALCKTITEGGSWEVQVSLAAVGQWIRSLGKVSPEEAFGKGKPLPSSSFPQHEEIQRLSVDWPQSNQLHGRSRTMTALRHAAVLSRTPVREGRVEEGEPGAPLVLDSSQATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3R9</accession>
    <name>A0A8H5D3R9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3R9"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="480" mass="52475" checksum="37607B39D96B2C06" modified="2022-01-19" version="1">MNLHLLELPTDVLIVIVQYFGISELAALYRTCKTFFTLIDTYGWCNYLRRNPRNSLSLSRAYETWSPARRVRYNTLTDRAWSNLRFVARPLSRPWKGRFQPTLALSKTRLVVASGCTIFCYKFNVIKSDSSQPSVQCEGSLSLSANPDSRRDITSIVSIHDEESCQTLLCGLQDGTFTQVVLLSQDDANMTGKVTHLGNISPMGGSIESLSCEGSLLLSLSSTGEASFRSPTSLEPALSSIQLGTRSWKSYLTTKASTPFAAFGTSSKTPLAVYSILYGTELPEKPTVILDTSKDTPSVSSAVYGICSAPLSSPWGSSPQIVVSGWFDGQVHVHDLRSPIRVSSSSLYSSDSTTHQIPRLHPVLSLSDPWTFDPIYSVSSGGGAGSHIAAGSARHSVVCFWDVRSPKNGWSVYAPGNDRSPVYDVVLESSRLFGATDSRPFVYDFGPGVTQDTYPAVKADGLKTKRSNPIAYYVTKYSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3U6</accession>
    <name>A0A8H5D3U6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3U6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="80" mass="8438" checksum="D6DC6CC8488FAA96" modified="2022-01-19" version="1">MIPKSTARRSAPSASAAPTTSASISVSNRPTPAGPTSAAPAPPSPPTPEELAAQAIAERKRKFTQHVKTSDREFNGKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D577</accession>
    <name>A0A8H5D577_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_010604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D577"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="6">
        <location>
            <begin position="253"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="723"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="760"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="789"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5353795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="883" mass="96961" checksum="2B2C59B97D767B22" modified="2022-01-19" version="1">MNDPQSQRKIPPSVPNIPQPSEEARNSLSDAEKGQAGIGRRQSSEKSSAPAGDRVGNEKGKGKEPKFGPSQSVPASTAGVPVKPGSAAQHTGGDIGTNAALPQSTGHSVHSNSTASRRSSNAQDAWTDSEVHNVMEENSKSEPTVNNNTKDETAPGVLELEGDKSPDNIVVQILEGIAALLSSLPETNMGSENAKPSNPTYQHDAVKKQKNLHQLLGIPEYQSSYTGTRDYDYTQKYPADEFGKEAGENARVWKVYLDEAETFDDEMLRGFRDTLDALLVFAALFSAVVTSFVISTVVNLQPDYTRITASLMFEQNQLFRAAGNTTALNAVPQTSVNLDTADVTTNDLWINGLFFASLSLSLATALLSVLVKQWLQAYNFSLPTGNAQERAKIRQFRYLGFEKWKVPEIIGLLPIILHASLGLFMVGLSVYVSELHQSLCWIVISVTIISFLVYFGSIIIPVIHIQCPYRVPILFSLLQLLMFPLNIIQHLLKLVNYHGKKYHYRFQANHLQNLSQPKWPSAPDTSLRNAEAMFLHLIPPTWRDNYRLSSSSTRHHTMLAYCLKWLQSLQSNNSIQEVVHQAIHGVFHDTALKDSGGGISAFQPALNCYVELDWNSIQAFIWDTLRKRDETDNHKVCSSLYSLWRKAKEISHFPPQEPGYALHGAARNGYFHIVKVLVKNGANVNAEGGFYGFALQAAAFWGHLDIVKYLVEKGADVNAKGGEYGFALQAAACEGNLDIVKYLVEKGADVNAERGYFGFALQAAAFWGHLDIVKYLVEMGADVNSEGGEYGFALQAAAYWGKLDIVKYLVEKGADVNANAKASYHGFALQAAAIGNLDIVKYLMEKGADVNAKGGAHRSALKAAQTGRKPEIVKYLREHGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7B7</accession>
    <name>A0A8H5D7B7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7B7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034971169" evidence="2">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="165" mass="17547" checksum="0410A161333EEA67" modified="2022-01-19" version="1">MCRILVIVNVAVVVDSLSLEPIAPPTITLGQPFTVTWHRNVQADPTDWFLLLGTPFFNDFLGQIVFDVPNSEAPDGTLTGSIPTTGVETGSMQIVAGERSLPNGKPWATPVTSIQVVRTDVALTSQHRNTDTASSTSRPQAVSPTSTSLPTKEVQADSTSDASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ET80</accession>
    <name>A0A8H5ET80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000572">
        <property type="protein sequence ID" value="KAF5311173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ET80"/>
    <dbReference type="OrthoDB" id="3363836at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5311173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="22683" checksum="620ABF4A5E2E0F54" modified="2022-01-19" version="1">MPSPHPVSPESHSQTVEYQHTPGVSSFLHPFQRSPRIPCPIRRLPARPRPSAESRRSAYERRSQAGQSRAFHFSGEDEPPIPEGAAERASMFVGGINPALVRAANTNPSLTGLTRLNASTTTVNTSRLSRFNDVYGDAARDSMYAVAYGAYAYSGHDDEISGAISPQQRNGPHALTKEDVGPALSSECFFLFLFRHLSSAASGILSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F8U1</accession>
    <name>A0A8H5F8U1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000379">
        <property type="protein sequence ID" value="KAF5327971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F8U1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5327971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30258" checksum="CDAF77B91D68547E" modified="2022-01-19" version="1">MSHTQHLLQICAFFHHKAIPIQLFQRAATFAGDDVLQGEEISGMAEMQEFLKLFEDNHLWKECVDELCQFSLASYDNKTEVLALHSVIHACSRETVDVVESKRNVAYLIIGCATPLEVKDKDYQFRRYLWDHASYMYGGIMPTVFVRICLAQILGDAGMWTQAEQLEEEVLGVRREELGEHHPDTLTSMANLASTYRARGKLEAAEQLEEEVLGVRREGLGEHHPDTLTSMANLASTYKARGKLEAAEQLEEEVLGVRREGLGERHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCU1</accession>
    <name>A0A8H5FCU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_016118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000312">
        <property type="protein sequence ID" value="KAF5332335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCU1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5332335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="478" mass="52678" checksum="75F349A2E549CD96" modified="2022-01-19" version="1">MTQNSRPSTLQSFQGDLVYPNDPSYSSAIARWASNAERQAALVSFPKTTSDISLVLDYALHQSKPPLPIAVKCGGHSASGASSSEGGVVIDLSRYFSEVRVDPEAKLAYVGGGAIWATVDEKTAEYGLATVAGVVNHTGVGGLTLGGGFGYLTGEHGLVIDNLVQATITLQTGQTLTLSSKADENPDLFWGIRGAGSNFGVVSEFVFRLSPQRRDVYAGVMVFPIDRVEEVCQVANAWWDNGPSEKERLFITLVWNEDMSEVVLQVAPFYNGSEADGRQVFKAFLELNPTQDLTTSLPYIKLNAALNDQFPHGRPYITTGFQTHRAQANPESIRNAAKLYKRHREEDSKLARPIKLNVSVIHEYTPWGKVSSIPDSEGGPFPRNRVNNGLMMATWAENEKEINLKAREMVDEIRNAFLDAKTNQKSEGPKTVEKDFRQSSASKLEGLYGVENYQRLKTLKKTYDAKNVFCSWLPIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDC7</accession>
    <name>A0A8H5FDC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_017444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000311">
        <property type="protein sequence ID" value="KAF5332338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDC7"/>
    <dbReference type="OrthoDB" id="3058388at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="764"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="8">
        <location>
            <begin position="890"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5332338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="140439" checksum="80409AD4FC289CDC" modified="2022-01-19" version="1">MVERDRPDPSVVLPEGSKRTHKRKNPDGPNTIVPPAAKRAANIPRHSANNGNPATTPPERQENPPNPHPTTRTSPSPLPHTPTPPPPTNPTLSHAPSQPAIIVIDDDDDDGKLAHRLQMPGRPSSSCVADHPHFKRKEALAYNFLVMENPIHDEDGTKLASCQMLCAFCLAKGEKQGWKWSTKAKGSTGNFIQHFKNSHGKVWAARSTEDEKIRHPNRTQAPGQGPPQKTLDSWADRAFDVEKANRLLSEWIVLSVEAFTAPEHPAFRRYITHLRPGYGKNMIKGDAAKNHVSAEFKDAEKRLKEYLTKAPGKKAFAADAWTSNNNIAYLAIIVSFITENWEIASILFDFPHLEGAHTGKNMAQILSKQIVELGLADQFSALAADNASNNDTLREELASILNSASTSTFYDSDNITIRCLPHAIHLAVRAFLIELKACDEADIDPNNIESANTWTEEEAESVVAQDEGLSETSDEKLLEEQDDDGVDIKAVVQKIRQVSKLTRSSPQRSEAFKKTINIVNAITTDPKAKLRILNLILDVITRWNSTYFMLKRAKELRPAIDELCIRNDLYKKYRITNEEWEVLDIIVGFLEVFRKESERMSASSFPSLTASLMVYVKLMQAVDSFLLTDTANKNPSVRKGLEACKAKLEKYYDKSTGESEYYYAAAVLDPRVKYKLFDSNPSLFSNEWRQEMDIAFKDRIATYPRSSFSTATIPTVSSQPTTSQKTDDLFNDVSLLGTPASSTSAVETVEEEYASYIADREVDECLAFWKVKCTKYPRLAAYARDVLAIPGSSVAVERSLSVGKDLIVFWFLKRDVQSADNPTIRRMPSADADEGLVVAHPSGWIRIRSASDPLGALTETPQVNLNHKIDPRRAQDRNRVVQQIEVATGRRKGTLNLDTRFNVMLLRADLHIAFDNDMWCLLPSDDTLRKIFELIQHNHKRSDSDKPKQLLEVCEFEQHPLVFSFVIDTFFGQEIPIPQDPKPIYLYRFTALRYSKGEAIHRRKIDFSRTTGVAYRPYQHFDDYTAHFFPFDDTDMQNIECHVHPFFVAYNSGMKMHRLFQVDPKLHDALIGLSEALQLAEDIYKSCHSIGEDENTEELSEAEQGAINDDPFQSSDYEEGLLGSSPAAPNRSLSTVPPAEAGSQEPIALRAEMDHSNIQSKSSDWRLPLDLSKVQYGGTSRIPFSFQAQAPPSPTPKSSSMESTRTLGSLPHEPSSSSSRVAGPSLRGSVVSMGEDRGNPAKRKRLNQGKRDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEH8</accession>
    <name>A0A8H5FEH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEH8"/>
    <dbReference type="OrthoDB" id="3123112at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="201"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="293" mass="31996" checksum="636841573E1148CB" modified="2022-01-19" version="1">MGPPLQLYFYIYKPCPDTWFPISTSLLLGPDNSGDSHIVIPTHHTFCPIFTSASVPSSPPSVPALPLPPASPIPSSAIPTAHPSPTLVPTPSPLPVSPAPLSPIASTITDIDMSSTTLENLLQALVNNQNQLQQAITNLVNRPVHESSDKTPKPALFKGEPAKLDSFLSLFILWAGEQKWLKLDNGKLNPWKCIAEALLMMEGPAAEWAAEYAHHISRVQAEEAGAVFPWEGNWDNFIHALKVQFGVANEQQLAKNKLKALKQGDKTVLEFSQIFKMWAEKTGFSVQVPEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFZ1</accession>
    <name>A0A8H5FFZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFZ1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="81"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5335023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="24658" checksum="FC748786D9291647" modified="2022-01-19" version="1">MKSNILFSDESGTSFTHPGPNYTTELIESFVAANFSPPLVSTQSFDGAVKQIVALYPEDPALGSPFNTGSETFGLVPGYKRAAALNGDIAFQSQRRFWIQTASNAGVKTFGYLFTQPQAGSGRLGVFHSSEVRYVYGGVQNPTPSDATLSPNMMDYWISFTTSLDPNDDKGSSRPEWPQYTPDNQVIIQLNGDNLTAIPDDYRKKQIDFINLMPLTFHHRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLM9</accession>
    <name>A0A8H5FLM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLM9"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5340888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="64124" checksum="038927F68627D6A4" modified="2022-01-19" version="1">MYLPFLCSMRDSLFDQSHVHFDSLLLAVGFGTVSYFVFKLSETHSPLHLAVLLIAIPSALSFSVQQHFSSIFLSICFIFSTYFFTLVTCIVVYRLSPWHPLGNYPGPVLCKLSKLWMAFVSQQGRQHIYLWRLHQKYGDIVRVGPNELSIQNAGSILPVLGGSELPKGPWFDGRYPEDAAARSLISLRNTKEHATRRRPWNQAFSSTALKEYEPLINARTSQLAGALGQQSNSVNLTKWIFYFAYDMMSDFIFGGATEMMRDGDVGGLWPMLEEAQKTGLLFSHVPWFGQLLFRTPFLAGNRRRMIACSTQFARNRKARRPIHKDLFYYLYNEGGTISNPPTEAEAFADSLLAISGGADTSASTVVNLFYLLLSNPMTYRRLRAEIDRHEDRALDFAEQSRMPYLNAVINETLRLLPPVPSGSPRATTSETGGRMLGTHYIPPNTALAVHIFSVHRDPRNFSFPETFLPERWLSEEDKKVLEPSLLDRHDFIHNISAFHPFSVGPSGCVGKNFAYLEMRMLVSKILVKFDLRFADGFDERKYKRGMKDFFTMALEPLMVQLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNN7</accession>
    <name>A0A8H5FNN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_011860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JAACJM010000140">
        <property type="protein sequence ID" value="KAF5343466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNN7"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="149"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="452"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="717"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5343466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="752" mass="84344" checksum="3274CD6A55B43026" modified="2022-01-19" version="1">MLRKLSAKRKASSLQSTSKKKLKVRHEHADSLPWKTVSRPLESGMGGDDGILDLEEVSGVEIVYEETEYGRIPRFKIVESEVQSEPEPEVEAEPEAQPVETDDEEIPEETFDSENLLPEWHQYALHPQLYKALHKNNFTSPTPIQAAAIPVALKQRDVVGVAQTGSGKTLAYGLPMLHKLLSEAPRKPPKTHRPLRALILAPTRELALQVSTHLNACLNHFPSDAEREKANEKSKPKSKGPPPKKPPPRLSVAAVVGGMSAQKQKRILDRGVDVLVATPGRLWDVIEDDDTLAREIRHLKFLVLDEADRMIEAGHFAELDNILRLTLRESEDDQIPEDPADAPMAIDIDANAEEKEEEDANDSKEAVARDQLQTFVFSATLSKDLQRNVKRRSRPKKLKKKGKPEPGSTLDDLLLRLDFRDPEPEVIDLSPKGGVVSTLTESKIECLSADKDVYLYYFLLRYPGRSLVFLSSIDGIRRLMPLLDLLTIKAFPLHSQLEQRQRLKNLDRFKSTPNSVLLATDIAARGLDIPSVDHVIHYQIPRSADVYVHRNGRTARAMRKGFSMLMCAPDERRVVRALMGNLGRDETEIQEMSIDLSMLDKLKARVQLARKIETAHHKVRKENHEKNWMRETAEAMEIELDSDFASDADEDHSTSTKRQQKAKDAKNAAMKAELKRMLAQPLVAKGVSVNYITSGSNPIVDGLLAGEYNDKMLGVGKNDAEHDLVKAKKKKKNGKGQSQKEEVKTEEEDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNS2</accession>
    <name>A0A8H5FNS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000137">
        <property type="protein sequence ID" value="KAF5343604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNS2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034194300" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="7914" checksum="B3AE6F4C5643AC27" modified="2022-01-19" version="1">MRNFLTATIILFFAQTLVLANPVAQSDSPDPIRGCGAFAEPIFPCPEGFTCCNSEGSAENSICLKLGPDEICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPE1</accession>
    <name>A0A8H5FPE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAA35-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPE1"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="662" mass="76966" checksum="7F3C231B39B8ECBD" modified="2022-01-19" version="1">MYNPSVMDALAMDVDYDIPGGDDFQDVTALFAKANAAMDPEEMVMMEGFSLQDAMSALEIGEPRLDTGMSTGRQRPFNPLTPLLPEELCWIMDRSMAYEMEWHSSNQLAHTVYTLLYIHHLQEIDPDMLPYAYLLVKDPNRPLELITIVLRAWVCGLLKCCDRVWRKLSKSELNDTEDWQPDKCEISLSEGWPTKAAIARLADVPSQWREALTVRLRFRLYLLQLIENDVHDNSSQFRELVHEAQRHLSTIRSYPTFEPTEDSPAHATFDPYIARRLNTFMPVRVVQLPTREETWAKLENWLDGLEELTRLAEITDVATWDIVGNLRNTLPTPTLRPGFAGFHDYFVSLNRFPSSWLVDRFFLETIGEGRYNHIYVANGSIHPAGVDTFVKEVLQWHIIYDMLHISTMEYLNTDTDTSDLSHRDLTLLLLTPCVPLYYRYSCMRDVILSGFQLELYSENEKDFAYWYIAKIIEGQLELLDRFVDFQAGSQDSETYQEMFFQRIFLTALQIMCEAMFLLLVRSNKSRSQPWSQMRQNLMRRYKWAFSENYEDYATPPVGNPPDLRRYLIEMGKVMDDNWNSASEAFSMAKSILSGLIESESAKANGCVGGWARDWKGERLKILDILAETCENLAKLKRKSKERKLIWDPTKSLWFPLVEKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSF6</accession>
    <name>A0A8H5FSF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSF6"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="12409" checksum="C110E7C6A5196A9A" modified="2022-01-19" version="1">MGAAGVVLGIRFLFTHECIYSQDKKDAIIQASLINSTRRTMAFDEVGRTMGWPDKCDGRALVNNIVMDLDEGLGLDARLKRFDESAASGDKSRLVVWAGEGVGLTNEISSASVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTR4</accession>
    <name>A0A8H5FTR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTR4"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5349420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="722" mass="80629" checksum="77735500D052443C" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGENTRTDVRDTVPTPPSSPPSTSTSSVALSMPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNALRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYIEESDAIELIKKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAATATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAAPYQKPSDVKKDRKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWVQSISSSDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLQLAGDMRVEIRKDNARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTTETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQPRYLNDPGEEHYAAAKQCYLYLKGTCDYWLNLGSPTITSTYGFADSDGEISWTCRPIQDLCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTU3</accession>
    <name>A0A8H5FTU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTU3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5348941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="40452" checksum="5CDC84690610715A" modified="2022-01-19" version="1">MAPFALLPFLKVVESLKLDPLPPSVSAGQILTLNWARELGDGDPPLVQWDLQFFQREPDDDQSQVEPLGDLVHVDHSERLSGTVTVTIPSEAPGKGQFFSAILQVTTNPPSSDIPPGIVVSVGRASSIRATNTSQPAPSIPCATTSASSAHHTDIGQAKSSSHSLRSGTPLSAKMTSGSSFPISTTGSAFSQISPSSPSTVSTALATAVTPSTNDGFGYPTSSGPGPSNQDQSHNSTSRTGIIAGAVTGSLALVLLLAVICCLRRGQRRRRQSQLTFNTGTSTPEAYHWWDMAHLSSASPRRRSDILPVSLPTVIRNHNSIANRHDSQSDSGTLFGFTGLLKDTQDRAEGSGLSGSGSRPRHSDRVRDNYLWERMMRMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUN1</accession>
    <name>A0A8H5FUN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUN1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034801193" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="164" mass="17548" checksum="4B1550508AC1EFAC" modified="2022-01-19" version="1">MQFCTLVLVSALLPFLSTGYASIVEHVDDLPTQEFDFVVIGSQHVGIGSCDKNDLNTKVPSFFGQDMGSPLDWNFTANLGLAMDNCMGTVVRGFVLGGSSAISGIVYTRGSSNDWDCYADLTAIPDGLGTAFNSTSKRTRALLNLQTSTTYLGSSTQQYMVSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV53</accession>
    <name>A0A8H5FV53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000078">
        <property type="protein sequence ID" value="KAF5349872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV53"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034270993" evidence="2">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="174" mass="18403" checksum="8EEBAF069014A243" modified="2022-01-19" version="1">MAFTKSTLTSLFLIAAVGSVSVTAQSTNCFSGEGESFVFVTILDLIRLLVVVPCLLMRIPELNRTFSLDILLPATNFNRSALPADFTPCGGNCPPPSPSTLPIALPSDFFKGADSCCSTFTITFDGNTVQGTYAYKSSNLAGTRIVALDNDLYAQLGGNPNDPSGGLFPVQFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW08</accession>
    <name>A0A8H5FW08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW08"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="335" mass="37501" checksum="578AA70A1C951C1C" modified="2022-01-19" version="1">MTFQTRIPLIYGGGGIGAPGTDCKLTTTEAAQPIVDEFCKHGPMAIDTSALYGHGTSEQIIAEMNLHSSRVDTKVYPIAPGDHSPAKLRESCEKSIAALKGHKIRVYYLHAPDCATPFEDTLRTIDELYREGKFEQFGLSNFKTYQVGEIVTICRKNGWVQPTVYEGVYNPLDRTIETELIPALRHFNIKFAAYSPLAGGFLIGHLLDEGGLDNVEEGSHFDPKLPFGMWFQSRYRKMIGPVRELRDVAEKHGLNLNQASVRWLQHHSAMIPSDLGIIFGGTKTSHVSRTLEYSAEEPLPEPVVQAFEDCYLKVKAGVPNYHHDPAWYDPKKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZD6</accession>
    <name>A0A8H5FZD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZD6"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="300" mass="34572" checksum="C8CE9DE70D7F4699" modified="2022-01-19" version="1">MQPSICTTYPSKICYDWSFRSTSLLWWLWLKFPPSLRACAYRQLLQRFQVGDKRGPVTRLRFGLYAKIAPSSDEALAVQFVRAHTTIPVPEILDVVPYSPDPSTDTSSWLILSKALPGSPLFQNGTPSRLIHATTEQIANLGEVLSDWIDQLRRIQPPHPQRVCGISGGTFRSHRISDVLVEPFESPAEFHAQFFCTVLDPSADDKIQRLVLERPQKQYKICLTHGDLVPQNILTDDSYCPTGLIDWETAAWMPEYWETTSSIRTHFSRMYIWKDIVNKYFPQYDDDKLLEFHIMKTYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1D2</accession>
    <name>A0A8H5G1D2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008303</name>
        <name evidence="1" type="ORF">D9758_011620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1D2"/>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="80" mass="8794" checksum="C8A22623B6AF69C1" modified="2022-01-19" version="1">MPELLGTKDGIEALTEFIQKSGAFTKTGKPLHPPQPPNYQPLDETALMLNDEYWEDLTGGSERDVVTQGEVVDDELGDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3H9</accession>
    <name>A0A8H5G3H9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3H9"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase C-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="86" mass="8999" checksum="82B4646108709BFC" modified="2022-01-19" version="1">MHVKCVALVNDTVGALLSRAYTAGGCVLGSIFGTGTNGAYVEQVANITKLGNSPAAARGGTMVVNTEWGAFNNSVSHLLYLYPHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3J7</accession>
    <name>A0A8H5G3J7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_007472</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="879"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5357586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1416" mass="155799" checksum="1D0EF911C3DCFD5E" modified="2022-01-19" version="1">MADDRLARVVARLENLPSIALPTDYPRLSGTNKLVEAAHLAQLPEQTSLSLLKLAVYTENDDDEDADENLKRPTAFHLLLAAFTVLLHRYTGDTDIVIGSSSASSRDPLVLRLSVDPADPFWAVVRRVQQVEAEAEADAVPFELITNALNKNRDDPLEGPIFRVRFFDEMGESLGDFIRSTSLTSDLTIFVTRPPASTRESIAPHISLRILYNSLYFTSARISYIVDQLCVLLRKASSNPLSPVGSIPLLTPSQKAKLPDPTADLNWCDWKGAITDIFSRNARQWPDRPCVIQSVPAASLTDPQEKIVFTYGAIRRASNILAHYLLKGGIQREEVVMIYAHRSVDLVAAVMAVLKAGATFSVIDPAYPPSRQTVYLRVAQPRGLVVLQGAGVINPSVREFISTELKIRVEVPAVRVLPSGDISGGTTENGVDVLGSHKQLGETDPNVILGPDSIGTLSFTSGSTGIPKGVKGRHFSLTHFFPWMGERFGLDETSKFTMLSGIAHDPIQRDMFTPLFFGAQLHVPTADDISTPGRLAEWMADSEVTVTHLTPAMGQLLSAQATCQIPSLRNAFFVGDVLTKRDCHRLQALAANVQIINMYGTTETQRAVSYFAIPPVSKDPTFLVTQKDIMPAGEGMIDVQLLVVNRNDRNVPCAVGEVGEIYVRSGGLAEGYLDPDATKEKFVMNWFEESRTTPRKDTIKHPLGHNLPGPEARYWKGIRDRMYRSGDLGRYHPGGIVECTGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRRDKDEEKILVSYFVPLQGAALDDYASEVPDDDVAKGVSRGIKKYRRLIKDIREYLKKKLPSYSVPTLFVPLHRMPLNPNGKIDKPALPFPDTVQAVAAAPAQAGNTTEEIMRKIWASILPNAPQPIPFDESFFDLGGHSILATRLIFEVRKQFVVDAPLGLVFDEPTIRGLASAVDRLRNADLGLSTSETAPSASTKGPTTTPVEYGQDYENLVLKLRQIYPSVLPDFNTHSLTVFLTGATGFLGAFVLRDLLSRKERVAKVICLVRAASVEKGLERLREGSSDRGVWDDSWVDSGRLEVVVGDLAQERFGLGEQWKRIAREADVVLHNGALVHWVYPYEKLRAANVLATLTATELASEEKAKVLVFLSSTSAIDTEHYVQLSESLAMRNPEYKGVPENDNLEGARSSLKTGYGQTKWVSEKLLFEAGRRGLTGHIIRPGYVVGDSNTAVTNTDDFIWRMVKGCIQLGLVPDMNNTVNMVPVDHVALCTSLAAVSPLPDAAQSVLHITARPLPTFNSMFSSLLQYGYAAEQCEYIVWRRKLEQHVMEAQDNALYPLLHFVLDDLPTSTKAPDLDDSNTCALLRPHNPQVNVTVSDSLIGKYLSWLVRAGFLPAPSNPSPEKVLPDLGAGAFKAAGRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5P5</accession>
    <name>A0A8H5G5P5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_008597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5P5"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5358755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24498" checksum="0DBD7B47A5B03DE9" modified="2022-01-19" version="1">MAVVPLEFTKDAMAKGDFIPSVASRSLEKIASEPMSMSQHQPEPEKVLQAVLSTMYTDKTIFSADHDLHNNLQKDWYTQLTVSALGTFIHGLVKNSNTMKKGQRAVDERTGGARLPDFSDCGSIPYVDALFLETLRWIPVAPLSIPHKSIEDDEYNGYYIPGGAAVVGNGWAILHDESVYGPHPHLFNPERFLQEDGSLSPNVLFPNAAFGFGRRLCGGKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G6A6</accession>
    <name>A0A8H5G6A6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G6A6"/>
    <dbReference type="OrthoDB" id="10642054at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="668" mass="74144" checksum="D8E4F0DB5B8AC355" modified="2022-01-19" version="1">MNPASYPGGPAPTQVNHQHQNTTLPPHLAFSNQWQAIQIVSNVANTYKAENAALRADNQRLHNDVQQLNQQISQSNETCSVWSNENLKLYEDNTRLNGKIKKLQETVETLQLEQDGLKSKLSQSTEERYVLLWNDFLKLRNGYNQLHAHASYYKSFVDEGVQRGIIQPNTHQNPSAQPVPPVVPSPTRPSQSHASQLHTLPTSVQSHMQQAQHQQRVSNVPINSGPQPPLHPNQMPPSARPNLHLVTQVSSANTYPQPPQPTRYPAIPHPPPPTQQYPAHVSQHPNVPTHHYPAHASQLTPITPNSGHNSPYHPEPHVQTSPSHVAPMNMLPTPHMPVHIPQYVHTHQFPQRPLQDPNRLPHESPRDEKNHIPPPTPISQKYPTPPISESHTSMSPETSWSSVSVKRSDSPVPVVGPPVPSLQPKSESNSTREFSPTNVSGQKRPSMSFESRESHSPKRPRLSVEGLDRGDPGLSKEMKEDPALAYQPKAVEHTSLAFSSQQLGSQQTTEQNASLEPVDAPSRVVQIAAVPPEQVDRMEVEPTLDSQEGAGDVQVATVPPEQVDVAEAEPNQDSQKGDTDSDGEPQRGPDGLYEELDAADWFLVGTAEDEGFGDDGLKICVLCRERVRNKKQVPPYQFVNPSNEEILTHFRTHHSTAFTMARREGPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G809</accession>
    <name>A0A8H5G809_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_007544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G809"/>
    <dbReference type="OrthoDB" id="3222453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="706"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="706"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5360062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="935" mass="103036" checksum="81B11264D7E677E9" modified="2022-01-19" version="1">MGREALTRQDAYAGQLFCHGYGCPLLNPEPNVIGTQWGTLLQDIYAKGIRVGDVGLIRPSGDYCSLFNIFRAKEDPINTVYGVPSDFQPLEFRPNLLFSTLHHYHPPNARICSKHTREVKIDAEGTVLTPGMPFGPGIGLEMQFSRSQGAVLLLPAGARRVDYDGLPDIREYAKKHAASWYRYLNDQVRIDAHNGSLYLITGFDRTNCYENVAFQSSSKASSFSLRFSSPLLANGDFGRLSLSYSSLPEHEHWRGTSSPGHMLDNLSPFIRGFKIMIKQDFRYRPSAKLMDLTKTDPKALIYRGPVPNLAGGSPSSSSLSGSDPSHSPAPSSASFSSGSSSTRSSRHRASQHPSPHAVQWSPATSYSSLAEDIDSVRSDSLSPRGSSILGSDLESESGLPVFQLHHPGDIINEYILDKCPDALVAITHDKEWAAILEETDSQFPDNFTLISRMLRKFPSKFHQDDTLFDDLSPTTRHVDMLDNDKETAMTMPIGRDHSRSHDDDQDFPSRRHELNLDKPIDICSPVVKTEDMDTDFYSSHCDRLSRAYADQKRDRELQSAGSEPFSFSISSWETSSATTATPSLVSDSSLTMNFSLDGNTSRVREYSLDFGFVKTEDLDNNLSHCDRFSPGYSSYPGYRKMQSTIFQPHSLSIASWEANSVGAATPRLICDSFATDSSSTQGSGNNGNISEAFRSIFKGRKSWKTQKGGEIVWPPELEAALLEGLAKYQPDNSRETVLLGRYPMRNRFISEYILRTTGKYRTAKQVGSRLQQLRNAPSKELQSLLSPVCKQDAPTGISKVPIGNVKPSPTPLSSSSLPGDGYRFSGDSGWSASTSATQGSFVPSLSSPVAPASDGRARSLFYSTHMVYGAVREDAEPANAAYGSPAKSYSRSSSVYYEGSPEPFSSCRVGFRENTSDQREMGLHFAWDNEAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAE3</accession>
    <name>A0A8H5GAE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAE3"/>
    <dbReference type="OrthoDB" id="412006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="263" mass="29414" checksum="99EE2FFAB057585A" modified="2022-01-19" version="1">MKNGKATRPGTIPNDLFNAARDIIVPYLGPIHRAIYNLEIYPNDWSLRKLGKPDYRPIILSNGHGRLANSCAAGDIIKCAEILGLLPALQFGAWPGHNTMDSIHLLIDCIKALWRKGYVVTALFMDMKGAFPSVDLDMLCHELRMSPELMGNGGEDQGDPFLVVGYILYVAGLLRLIDKLANCEGFGFMDDVVVISWEKRVKDIHEQLGFMIMRHGGVMEWMKEHNCMFGIDKFKVVDLTRKKMGLRDEEGRPGIKVGDGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAL3</accession>
    <name>A0A8H5GAL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_010317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAL3"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5361270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="939" mass="102873" checksum="CBC04A765706B700" modified="2022-01-19" version="1">MLSPTYLGHTPLSIAIKAMTSNQAPFFNDFVVHKRTYLASVIVSFGAMSLGYDTGVASGVVVLPSFLYSVTGTTTLSPAAKADLSSNVVSILFLGAFVAAIVALPVTLRFGPRIALALAGIVFTTGAIVQIVTEHSLAAVYVGRVLSGFGIGMISNAANSYIAEISPAHIRGKTGTMFQMFLVIGSIISFFTVYGVSKNLPGVPSSIQWRLAFGLQMPGSLLMLSGLAFIPESPRWLAYRGNVEKATSVISWLRQLPETDLQVTHEIAEIIASINEEREASQGLTIKEIFCKGYRDRFMFSTSVVVFFMFTGQNSILYYGPIIFASIGYGTNAGLLASGLFGVIKVACTPLFAIFFADRFGRKTLLQVGNILKAGVLFTFAGLTSSKIDPHSARGNAAAAMLYLYMVFYSFSYGPLIWIMISEPFDNKTRQWGVMYAVALTWILNYAISKITPIGINNIGYKFWIVIGILNLLAFAGTWVLPETQGKTLEEMDIIFSKTTPVVREANIEKALGHKVNETANSYSKHEDSLAVVPTATCVEHDVLIIGGGLVGLTLAQGLRKRGIKATVFERDIDRDGRTQGYAITFHWALECLEQMYPKDIFDRLDDTSVDPNLSFDEGHFLVIDGRNCVPILDIPPSKRRIRANRSKFRKLILERLDVVYEKRFRSYEIIPDGVIARFEDGSSFKGSFLVGCDGNNSLVRRQLVGEEKAALKPCGITMGGVVQYFTPEQAKPYRDIDPLLFQTIHPETRNYIWYSVQDVSDDGKTIAVLTMVSHPILDPTDELSKNATSKQVIADIKKRAEGFAEPMFSLLNNIDENLPATRIHLADWIPVPYNSQGRVALAGDAAGPMTMFRGEAVNHGSLDAMLLCDVLTKHTRGKIDITEGIEKYEAEIRARRMVATPLSRQAAIDAHLPGGFPPDSPLVTQRAAPDIASTVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDU1</accession>
    <name>A0A8H5GDU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_012625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDU1"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5363087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="558" mass="59877" checksum="E63AA67E42A87B3F" modified="2022-01-19" version="1">MYGLPRAPAGHDVARKPRQGLDAAWKSSQDSSSRSSSSTSPPCTAVSLVSVDSSTTHSTTNPSSHALQTHTPTPHDENDESPSTYYSDPTVFPPNSMAEGYFDAFFRVEKKLGMGANGSVLLCQHVLDNNPLGRFAVKKIAVGQSHAYVLQTLREVKLLERLHHLNIVAYHHSWLEPTQFSPFGPRVPTLHVLMPWAEGGGGGSNARFTFLLIEIFILFFEIFYLFTDVQHTHALSLSLKLLNPSLHTRLTPTDSDPDPPVALEVYDVDDAGVDIGGEGEDDVHWDGHGHGNGAKKTNLNPNLNPNLNPAPPPIHLIPPIPPPRPLRTNQIHPTRRRSHLDSGFGLDEAGDADGKHEYDASGQQDADTAEVYLALLENLIIPRPEDRWGVVRDMDVRQRQGSLGNRDQRGSGFGVRETDAGVGEATLRGCGRKMETGMGMGMGRYANGVGVGSVGNGYNGYANLVNGDVATAASVGAVGVGVGGGRGLGLGLGGRYRHRHRQNTNEASLASPSFSEASASSDSTSTSTATATAGTLVPLYKGFRVENVLPEPAWDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE41</accession>
    <name>A0A8H5GE41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_008374</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034271045" description="alpha-amylase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="14">
        <location>
            <begin position="30"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="13">
        <location>
            <begin position="386"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1487"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5363224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1577" mass="171208" checksum="56ABDB26A4AAAF9D" modified="2022-01-19" version="1">MKTAVGVLALCVLSWAQRVLSAPDSTPGRDVIIQMFQWNWDSIAAECRDFIGPAGYEFVQVSPASEHVQGNQWWTDYQVVSYKLDSKRGNRQQFANMIATCHQAGVKVIVDTVFNHMAGMDSGVGVDGSSFTHYDYPGIWTNQNFHHCGLTSNDDIQDWNNRAQVQTCELVNLADLATETEYVRGRLAEHANDLLSLGADGLRIDAAKHMATDDIANILSRLQRQTYSTQEVIYGQKEEIQPKEYVQNGDVQDFRYTKALRDAFTGGGLTGLQNIMYQQDWLPSSHANVFVANHDTERSNGQDSLYYNSPSNIYVLATIFSLAHPYGTPTILSSYDFANNDDGGPNNGFGTCTGNGGSGGWLCQHRWAAVSGMVGWRKAVGTSKINNWYSPPNKPNQIAFGRGNKGFVAINNADMEWNLEREGVKTQLADGVYCDVVSGNKDGERCSGVEFKVVGGLVTATVPARGAIAIHLSSKPSSLYLHPTSIQLQRGKLMSSGIGRKRGAAGAGNGIGLGPPPPSSPSNQRIVSNPSRLPQPAPSASPSRLPRISAINDSGRRGHHKQSASLTIPRHSDNGANGLTLASSLSPNVHKRAPSGGYFGASASRIPLAGTPKVLSPGATIPSAMSMPTIRTPSKIPKSSNEPSRLPTASSTSKLTPSLHTRAVSAIPNLKPSSQLGVDTSYGQNQRSTSASQLGRPAATGSHHVPDTSSLKAGNRTRRTVSSTAPGPVHAVGTVSSIVVPSPRLKPPKANGPPPIAFNADVKNKALPAAPPTLRQLHQLQSESDARRQVPVITGGKPRRQPQASPTQLLKSTIPTVQIQGDQSQDILQALPIPPSPLTAENIKVQPGPLTGTNDIQGVKLSQLAAQEQIPSLPPPDPVPMQARRFTKPHPTLILRQLQMHLERLRTLEDNDDQEDIQHHQQHQQPRHHRYQLQSNISLDIDELIAIHDREQIENEGMMKDGYKEMLSWEKWREEEDGSTLSATLNMLARKRKMEKETQRLAVFAQPLHQISLYASTTGISSTPSKAQPSHGQPEKGNDTKSGAGQVVTGPARGYEHDLPIVVCKCVQELVVRGEAELDVILDNMALDIVRLVYCLPGTGTYTSATPAKTRTSKPSKPSERLQILIQTFNSSSQQHKFGAFISLAGESTEDVWALLERFLEDLPEGVVGGIGEVGRDVLSGDVDMKMKGSDNAGGGGDRGRGAAVNGLGKSALSYGISRALWEYCIDDSCFQDEPTGTEMILKISMARLLLRLLPSSNLSLFAYLMGFLSWVVESRVGTTQDEMLDDDTTDGIAERQGLGLGSLENDPGALELVRRFGRWMFASTVWDVGVGFGCENANGVDPVEKSPTVMMLIWFLRHWTEIESRLFDEIVEMEMTLLDLHESAGKDHDEDQTPRVVYVEGGPEVGGHEASGRTGIQHVANDRTPIQVRRRREDSDLLSLCSATSSALDERLLEANDVDSDIEASFSQLQLARMSLSGLPPLSAVDEIPSTHFGQEPPSHPDITPLHHSSSDSESEDYGRKLRVVNRAASDGIDFSDDDDSEEKTSSSSRPPPPLFSPTLIAAALRNLLSHPSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHX8</accession>
    <name>A0A8H5GHX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHX8"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="10">
        <location>
            <begin position="729"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="944"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5365178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122426" checksum="1E50A12BE3D01E13" modified="2022-01-19" version="1">MPRDMDFIRVNSLSLTPSLGGGSRWPPKNPALQPKPQPILVTLTVPHDIQSTARTDELEHSINYSTLASTIRDKVDDERKSFQSLEDLTGFIFDLLLDVNADTPRLSGARVKVTQVKPPLHCKSVSVEAEATSSGNSSWVLSSTGTIHTIEDLECDLIVGVNSAERLEKQIVRINIAIHTPTLDLRDREHWIDFRALSRTVYETASNTSYQTLEALASFIAVETLKHLYTSSFSSPSPDRPLSPKVMIRAAKPYALVFAESSEVEITRTREDYPDHFASSSSSASTSISTITPVPPPPPPHGNQPEPRHQPQSQSKVYTAAIALGSNLGDRYYHIETALRLLEKPVEVFSFETILSDPSETQLEVTITNTSFLYESPPMYLTDQPPFLNCACLVRTNIPPVELLRLLKKIEKMVGRVPGVRNGPRKVDLDLVLVIDGDGNEADGDRVGERDVEAVESDEGPADAANTTQRRDELDQEKMLEDPEASKVKDWRRKLQRTFLNFKSAIKEEDMPTMDQLFTTIESYDKMNREYLQFSKVGKVMRRINALEPDKIPRENEFKFRERANVLIDKWHAILGQSAGKAATNGSNEVGQGIVDTRPAHKRVNLEIESLEGELVVPHPRMQEREFVLRPLYDMIPTYKHPILQKTISELLWELDSSSSSPTDGPTNPMRRVIPFPRYPLSPPSSSSEPEPAPALPVFPFIDPIPPTATYWTYPYPDTDTSLSSSYRTYLMSTLNTTPDSFSDGSQHNTLHTALSYAYDSFVNNADIVDIGGYSTRPGAQYVSVEEEIRRVVPVVEGIRRGGVENVAKISSARPLDGGEQEEEEVQRLLEILPGRNMQGTEGIEGSNEKGMTTMEHILISLDTFRPEVAKAGILAGANCINDVYAFCGPSYVGTTTTTTVAEEPLLFDNKSPSTYMSEMKSIARTLAVPVILMHSRGDAGSNKDYSSYAASSSSSTTKADDGSDAPVIEAIRVELGEKVDNIVLGEGGVRRWFVIVDPGVGFSKTVEANLDVLRYAGSITDDVFVGTGSRSKRNPLVGYPQLIGPSRKSFLGSILAEGPGGRQTKAVERTFATAAAVTAAVQQGALMVRVHDVREMGDVVKVADRLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI78</accession>
    <name>A0A8H5GI78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI78"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="18913" checksum="112D4627FD87FB27" modified="2022-01-19" version="1">MPVARWLRVEEDFGSGVAVDAGAGGCSSGSYHLSSNHNNGGKSEGTSVKGEEWSERVFCNVFKDFGTFSYRRYVTANASRSTVTSYSHRHPSTYTNSFITTHWLPIPYYRREQGVRECLTRIGFMCLDKIDRNGPARLDILGVRLDGCTMYLAGLFGSVTPVFLSCWSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIP7</accession>
    <name>A0A8H5GIP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIP7"/>
    <dbReference type="OrthoDB" id="2756615at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="580" mass="64011" checksum="D69A05FFF9CC9C9E" modified="2022-01-19" version="1">MSDSVTIVLDDYLLSLGGDGDFGLVAKGWGSDTCSTYYNTTCCSVNETATEATLIVRSALLNAASWSVFGSTPPAPASYRLTLTTDVSRGETVEQNVSFQYPHFTSYQFFWTDFVNTDDFRNRTKDQEILFVFPKSPPTNIDYILVEVRNTTSLGGRTILVDDSNSEITWDGDGWVENRFSSPIRLFPDDNLAPETFYLPHYNGTHSSNSEGDSFTFRFQGSFISVQGISPLCRDCQLQMNFTVDSNTTLTTFSSDSITEIGIPHFLYFENQSLQPGNHTMVATITLVQGNTSASIDYLTYKPAFGTVLEKPVFSPPTLQSPPNTPPQTTAPDGPNHRSRTPIIAGSVSASVVVVTLGLLLFWWTRRSWKQRQSIGTIEPFKSLALDPGHSERVKGQVPSQSRNFIVEDSGRKGLPPRVVAVNALPTAAQLAELRSQNEALNRGLESLETRSVQQAPVRENVDFANLVREMRTQVNGISRDISRFVVPPAYESAAEGMDAQRRGGDGEGESAVIVSHSARQRDGDSVIEDGQENSMEDSANQNEIEVHLREIRARMGAISRDINRYIAPPAYETDNGMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJH3</accession>
    <name>A0A8H5GJH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_005696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJH3"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="38760" checksum="5A210A8772AF7944" modified="2022-01-19" version="1">MTPSIHRCNKTAHFYPMVSSVPSQHPNMFPSFNSYQSYSDADSMHYSCPQKVEPVFEYQEYSSPELDAWSDWAGQQATSETAPGRSTLSFVPKNQTDSSPEQYFESQAPYTGFSAKAPPVPSRPVVLSWPLEYFITNDPSLLTPGSDVSYFTSSARHTPELLYTGSSCGDDNVFDMQFGDALASNSINADVRSPYDSDSPASSPTASSPSSSSLAFDLPSPSRRHSPYKPLPSPTNTSSSSSGGSRSISALDHRRRFPCLLPGCDRRFTSQYTLKVHMEAHKPKPKVTFPCTHGCSERFSRQHDRLRHEVAKHGKVCEFSCEDCGRFFSTSKTLGNHKCPVAQGGTRWVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJW7</accession>
    <name>A0A8H5GJW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJW7"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="33336" checksum="D8B59F2A74392767" modified="2022-01-19" version="1">MPLDGHSYLVSQGWSGKGTGLRQGAISRPITIAQKNNLGGLGKDRDEAFPFWDHLFTAASKAITLKIDNSDESDTDSTTPPVPLLKRTSTGILSNRRPVDLPSTSTSGTSTPEPSNRLSLLAHAKREAARRHLYSRFYRGLVITQDTDTETLPTEEPEVPTIAIHSSESPSTSTSSPNTDANTKKRKRKPSSDEVDGDAERKERKRLKKEKKAKKQLKEKEREERKEFKAKRKLEKQARRAKKKRKMEEKEEAVIKEVVDDGVRHVDKEERKKLKRGKKAKEREKRTERKGGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL98</accession>
    <name>A0A8H5GL98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL98"/>
    <dbReference type="OrthoDB" id="3061128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="8436" checksum="0901A32A4467AB48" modified="2022-01-19" version="1">MCFLIQNIHNNAWTRTIPPKPSTKNPPPDPSQLDDALLQWSVKLDTKNFLSPEELKSVQLFRRAADYIAAGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM00</accession>
    <name>A0A8H5GM00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM00"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="78548" checksum="B8C90F11B7F4CEF0" modified="2022-01-19" version="1">MTSIEYPSELQSVICAHIYAACLPPDETSLDPLIISEHGIPTSLPSSLPPSHWSEPVTRHTLASLCLVNHAWYEAAKPWLWRRLEVRLPRSWLSLVEEIAWDHEEETVDQVMENTARAAARAAMASAAKPRMLLEEDAEQKLEESILDSIRMPEDPIPLELLSPVASREPSPRRFRTKSKSPARWELVRSISDAIQTVIHRNEPGVYVPTIGDPCPGRHVRHLDFNHFRTIGMRRSVDEGVNSRFVTGDRVEAVLKEMPNLTEFGATEYMDGALTLSVLNELFLRGAPSRGRGRPSRGRSLVIDTEEEDRDRRRECLELEAIDFTGCVSGVFVNALTEFVTAHLLPAEPTDSTSDAHADRLARLAIEEPLVFPGLQRLGLRGVKSSLPEILTPFIMAFPSLTHLDLSGTRASSELLETLGQSPTVRLKSLALARCVRLTSESIRSFIVDSPVCAGLTELNLYGDMTFVSPLVEEDLALIVAKAPCFVQGNLVYLDLSSAPLTTPILDICQPLPKLRSLGLSYIPNLSTKSIVSFILAKAKNVEVLTLVNTSPELDCGLRPDLAANFATRGSLRQSCFALHSDIINPLCVPAFSFSLISNKKHLPPTSLRVIELSTLLLSGLGAGAGSWRNIKSKGGRGWYVDTASGWVAEGGKSTLQRDLGPDHPLRVELGKMADANGNVSSGIGWHARKMEILHGHGMLGREDGLYGAVSFAYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMK6</accession>
    <name>A0A8H5GMK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_009862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMK6"/>
    <dbReference type="OrthoDB" id="3207336at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049509">
        <property type="entry name" value="DyP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21105">
        <property type="entry name" value="DyP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DyP dimeric alpha+beta barrel" evidence="11">
        <location>
            <begin position="104"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="10">
        <location>
            <begin position="299"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5367752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="564" mass="60665" checksum="A2D23AB7E654C722" modified="2022-01-19" version="1">MQHNCAISAKLSKYPERWGLERGSHLGLSLLLPNSSSPDLWIIMKLSLISVIICLAVQSALAAPKVNKPRKTAPLLINPDAQPDLPTARVAQAAADAAGLNITDVQGDILIGMKKNKELFFFFGIKNATDFKSKLSSDIAPLITPTNALLPGSTPPDTAVNIAFSKTGLDTLGVTDDLGDISFNGGQFTDATALGDPGTGNWVPGFAGTNIHGVLLLASGTVDNINDELASIQSALGDSITEIYRLQGAARPGDQEGHEHFGFMDGISQPAVNGFTPDVHPGQMNVSASTILLGVDGDNTRPPWATGGSFLAFRQLQQKVPEFEKYLVDNALDMPGLTPQENAELLGARFIGRWKSGAPIDLAPLRDDPDLAIDVNRNNDFTFDHPEIPGFDITTNQTFCPFSAHIRKSRPRDDFSPDESFTRPIMRAGIPYGPEVTDDEKASNTSSSDPSLERGLAFVSYQSDLNTGFRFIQQNWVDAADFFFGKSHSGECPVRQPNQPFDPIIGRDSNAGSVAPPDSDRTISGSDPLDKNHIFTLDIDFVVSRGGEYFFSPPISALTGKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNT8</accession>
    <name>A0A8H5GNT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNT8"/>
    <dbReference type="OrthoDB" id="3349961at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="129" mass="15111" checksum="BAB14BFBE4755BE9" modified="2022-01-19" version="1">MLFRTRSKEVAWEVVDTRDVEPICMYSEDEDLDLEAISDYDIRGTYVFDIKTKTSYTASQSAIVFAQQQLLKEVEKKGYNIFLNESWRLTVLRRKAQYRLEVEYCGRPAHVHGETPAIKPPPFMEVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPA6</accession>
    <name>A0A8H5GPA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPA6"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="225" mass="25243" checksum="1AF3C2D414D8F1CD" modified="2022-01-19" version="1">MSNNPLTFNQTVRGIAEFIEVAIHTILYVRQIYPAEIFVRRKKYDTPVFQSRHPALNEYISGAVKAITDELILGNVDKVVVVIKDKGDVALERFIFSVETMIQVENFNKDTSQISVENAMTPLSLGQYFRSFLVKLCMVEAQLGQMYLGEDVSFAIVIELKDDKPPTGSNPKEPPPWVPAEGQHTTSGAGDDAELHVIRAVNTGIINLSLVVQESEEKLHREREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPK0</accession>
    <name>A0A8H5GPK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnogalacturonan acetylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPK0"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034852230" description="Rhamnogalacturonan acetylesterase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5368639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26416" checksum="78E170A852F22700" modified="2022-01-19" version="1">MLFALSALLQLACLVSAQTVYLAGDSTMAKGGGGGGTDGWGVYLPQYLNIPVVNMAVGGTSARSYSESGLFNNLVNAVKAGDFVIIEFGHNDAHANPDNGKQDAVGDGYDITAVVTNAAGQQILIHSFAYYIENAINPMKAKGATVIISSVTPDNIWTGNTVGVGGRFVDYAQSIGRNESIIYVDHNAYVGQAYDNLGQTTVNTFYPNDHLHTSPAGANVVAQAFVRGLLCSKTSNLIPHVNSAGQAVPNGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ08</accession>
    <name>A0A8H5GQ08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ08"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="44642" checksum="4AE07E30100F10D6" modified="2022-01-19" version="1">MTTQIINKPAPGVPFFTPAQNPPSGTALESQPNDKPIPKLFTPIKIRNVTFQNRIFVPPLCQYSADNGHATPWHTAHIGGIVSRGFGLTFIEATAVSPEGRITPEDMGLWQDSQIEPLKQIVDFAHSQGQKIGIQLAHSGRKGSTVAPWLHPNAVATPAANGFADSIVGPSPVPWSDNNPVPQELTKAQIQELVKAWANAARRAIRAGFDVIEIHNAHGYLLNSFISPVANRRTDEYGGSFENRTRFTLEVVDAVRAVIPEGMPLFLRISASDRIEELDEPSWKNADTVRLTPILAEHGVDLIDISSAGNSLKQSFKVSSAQQDYAAEVKKAHGDKIVVGTVGGIKSGVQAEKYLQDNVADVCFVGRHTQKEPGCVWTFAEELGIQLHVANQIAWGFYGRGVASRMVKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRP1</accession>
    <name>A0A8H5GRP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRP1"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="6">
        <location>
            <begin position="102"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="671" mass="73667" checksum="8F80CB3913D13507" modified="2022-01-19" version="1">MATSHVGSIAENWDEALSRLIHLSRLILTQNLNYEVRVAELEQELDIYRRAHSVLVDTSDRRTIEEQARVVNFSRQISTPDHTNGNVGISQPSPPPDILPSHQRPLILCIINGEEIFFKPHLIQQGYTGGRSAGQLITRTLEDFFTEVGMPNVFGHVSLWVTLYFKKGELMNTIANKRVCTLDKLDSFLAGFTQTSPRFTTVDVGGREKTDVKIDEYLQTFIRFSQTLRVILAGCHNMKYLQTYDTLQAEGLLGKLITLHGPGEESLAPHNILSLTTEGLVALQNLPSVANRSSIPVGSSNTVTVNAGLISPQSPARGGRQLVDANLPLHKHRPPPCNEYYLMASCSKEGLAGIRMIMFSTQTSLSRWRSAPRKLPVIGSREAYPARLENGAAGDIPALMGATAPMPPMANAGSGERDVKDYGAGLFTPASTLPVSMYIAFIAPMGIISSRSIVSINLQHPHIVPQSSFAMSSHDEDHEDLRPTNTPGYNPSAAKTLQEYQKLDEGDPSLTKWKESLGITAGASTAGSGPKVTVLTLELMSATMPAGKSIVLDVNNAAQLEDTKKNPIIIKEGVEYNVRITFKVNHSIISGVRYIQVVKRAGLKVDKLEQMLGSYGPHPKGEAYFKNFDPEESPSGMLARSGNYTVKSRVIDDDGNIYADFEWVFKLAKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRS8</accession>
    <name>A0A8H5GRS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-69 and Arg-72) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRS8"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="286" mass="31082" checksum="347341CE606761EF" modified="2022-01-19" version="1">MPPSNNVDEFRNVLKTSKHIIAVAGAGLSAASGIPTFRGAGGLWRRYDAMSLATPRAFNSRPSLVWQFYHYRRESANKAHLNQAHHSLASFSLPSIRHQIAPDSTFTLITQNVDGLSALALEKALESASDADTNVDQPKILEMHGRIFDVKCTECDHVEFTRASPICPALEGTENLIENNTMDPEIALDELPCCSKCGALARPGVVWFEEMPKYLDVINQIVDRADLCLVVGTSSTVYPAAGYAEEVAEHGGKVAVFNLDRSSGDDEADFLFLGPCEETIATALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT31</accession>
    <name>A0A8H5GT31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_002042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT31"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034278917" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="20"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="644" mass="71680" checksum="258F55F52D499970" modified="2022-01-19" version="1">MSSARLLASLLAFSLSANAFYLPGAAPHNYAVGQKIELYVNALTPMLSENDDAKLKSLINYDYYNPQFHFCEPEGGPQSRPEGLGSILFGDRIFNSPYNISMLQDNATCKTLCVVPDVSAEEAKFINDRIREDYALNWLIDGLPAAEMKIDLRNGDMFFDMGFNLGNDDEAYETTPALNNHYEIVLRYHKFSEKDYRVVGVLVWPYSIGGPQQERSCDTENTTALILDEHTTQAVRYTYRVTFNATRWDNYLHIFDPRIHWFSLINSIIISVFLCVMVSMILYRSISRDISRYNAIDISEDVQEDWGWKLVHGEVFRAPKNPMLLSVMAGNGVQLCTMVAVTLVFALLGFLSPSNRGSLATVMMVCWSFFGSIGGYTSSRVYASLGGTDKRKNSFLTATLFPTLVFITVFLLNFFLIVAGSSGAVPFGMIACPPKVAILKLSAGTLLLIIVLWYGISAPLSAIGAYFGSKHGTIQHPVRVSQIPRQIPPSPKYLRPWASACDAAAIISGVLPFGAAFVELYFVMSSIFASRPYYAAGFLALTAGVVALTTATVSILFTYFMLCAEEYRWHWRSFLIGGGNAFWLLAYGLFYWASRLDLGSFSSVALYLGYLSLLVMLDFLVTGTIGFLASYWAVRKLYSAIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTK7</accession>
    <name>A0A8H5GTK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cohesin subunit rad21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTK7"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="597"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5370811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="75531" checksum="C4148C6CAE50EB56" modified="2022-01-19" version="1">MLPTDVLSRRGPLGKVWLAAHMERKLSKTQTLQTDIEESVDAIMDQEIEFMALRFSGQLLLGVVRIYSRKAKYLLDDCNEALLKIKMAFRPGVVDMTEEQLVANKNTITIQANAFDLDLLMPDPNWLADIEERPVQVHGQHQAHIDDITLRPTDIFDPFDYPQDNFDLGPSDGIGSQEYLDLELTFDEPLPDEEQNQDSMSVDGSVGVGRDAVHLDSIDAQFMDRGGMDYDMLSNKSRSRDPSEHPFGPDMNVDMPDFDGIDLGELNIGFGDDDVNMDGLPKEGEKTPGQTRSPSRASSPLTEIPLTPPPPDLEADATPNATKGKRKMKEKKQIIDSVTELQDGTQDGNRGRNAAPSKRDVSGILTEPHFLPKSSVVMRLMEIHNDPLAHFLPTKVTPNGTYFCAAPPGLAPELAEMFMRPLQNISNKRRGGSPGKSPNKRRRVDEQGNEADEVELGRRAVSQAPSIGMGSDVFRRESQGPDGLDFPDQMGMDDFQLDVPEVETAGVDLDRARSKSAAPTDRSRMSTPVDGIPDEGDENYADLTCPIAVFDARPQTQSQATEKESEPTDNEGKGYSRNTVKALSIIRKELRPTDGDERVLSFEKMADKASRRAAASFFFELLVLSTRDCIQVAQAAPFENIEVRAKDKLWERGPLNAPSRLGSVAPSAAPSRAPSVARSLASAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVI0</accession>
    <name>A0A8H5GVI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVI0"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034192289" description="Tail specific protease domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="69899" checksum="1E03112FFEF1C300" modified="2022-01-19" version="1">MVNTGSLLTALSALGFVLASKGQSDPCAKVGGQKWVKPADLRACFKSVPVDPVIKENILEVINKTLAFHTSVNYQISAPEPFTAAVHENLLKDLARISAQSYDSEYDLHIDISRIVALFLNFLPIPLVLLSTPSGTQTVSIAPEAFNVSSAEFPDEIDVWQSALPDGIALESLSGATVLSINGANPNVAIDANALITGSFEGLGTRQNAFFSSYQRSTTTWNYIMGNFAQQSLPLSDSVTLKVQRVGQYSTDTITLPYRARIGTTTVNFTDTASWRSGNCLVDESDFKKQDDPSSTTKAVAVKFMQQPPQPASRSKQLVNVMLDSTPLTDVVLPPELTPPDQSLNGSFLAGEFFMLDDGKTGVLALGSFSGDDFDTMESGLLKGLLGLKSLGATQLIVDVSNNGGGFICIAHFLHRILVGPKASTVPQAGLDTKARAGPLAKLIVKQIIDNNTDPNDQSLYNPLAWTNASNVPFPANFDWLDPSVDLVINGVHDSFSQRLGQECVPSGFTTTPPDQALFDGSKVVIVSNGRCASSCSLFSITMSKEEGSKTVVLGGRKGVEQEYCGTVGGQSTDFSTIAGELQAAGLQDNPLAPPNLLVKGTQGITWRLAFGVNDPTQPEEWQDHPATLNLPLTAELVNNPLAIWKEVAKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVZ2</accession>
    <name>A0A8H5GVZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVZ2"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="69"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="21603" checksum="8A2D1CBFC2FB71A2" modified="2022-01-19" version="1">MMNLKVVHHRPSTLAVASSVPHPCAFDTQPAPRNGYQVRLYLSFTPKGSTIEGQLGLSPHASSVKSSKVKYRATSLSRPSFLPDHADRFSFMDIGPLSKGHALIIPKYHAAKMHELPDEYLADAMPIAKKIALAQGAENYNILQNNGRLAHQLVDHVHFHVIPKPNEEEGLGVGWPSQTPSKEELQKTCDDLKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY68</accession>
    <name>A0A8H5GY68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY68"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="47804" checksum="D9C5A735C54FED12" modified="2022-01-19" version="1">MSQTTSASNTETPFKISVLDSQLDLLRKKLDLVTFPDELEDVEWRYGVPLADMKRLVARWKDGFDWRAEEKKLNEELPQFTRDIEVMEHGRLNIHYVHKRSTLETAIPLLFVHGWPSSITDVQKILPLLVQTSENGDFPSFHVVAFSLPGYGFSEAPKKSGFAAKHYAEIGNKLMLALGYDEYVTQAGDWGRLITYTMAQIYGGKHLKAWHTNMPGGTPPNFTSHPILYVQSLFEPFTAAGKAERERRIKFDREGRGYFAQQASQPQTLGYSLSDSPVGLLAWIYEKLITWTDAYPWTDDEVLTWVSMYYFSRAGPAASLRIYYEVTHSPDGPTGSAKNPPRIPMGASYFPKEPGNGPKSWSRAVGNLVFESEHDSGGHFAAHEKPDELVDDLRNMFGRKKWGKGKHGPAFGVVSGSNGFQPEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ48</accession>
    <name>A0A8H5GZ48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ48"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="524"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="764"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1268" mass="134944" checksum="5A247332F283F77D" modified="2022-01-19" version="1">MAKLSLQPSVNTTTVVTTTTTTTTYAPIPLPSLPSPTEPQDPKNYPLLHATLPQSLRHFSLTFPGGARAIFSDGDDGDHEMHDDQQLASGRGWRMLREDDASNSTTPRKKQRVPAAPPSPPPESIWPSAPPSPPPPQQNTAPFQPDLSVTTLLALPNLVNHFIALPPQLQSHLLLTLLRHSPLPVLRTLHSVLTPTLARDFLTLLPPELVSHILSFLPFPALVRASRVSKTWRAIIDSDPVLWRDLLKSTKIWFGGESEQAFANAIYARRRRHPFPSHLFLPHPYKILFKSRHLTRTKWLSNPDPKHISFPAHGHSVVTCLIFSHGRIISASDDHSINVWSPKTGRLEKRLEGHEGGVWALAASGDVLVSGSTDRTVRIWDLSDNPDDHKLGSGPDGKTRHCKHIFGGHTSTVRCLAIVKPEMVDVDVVDEDGRPTGVVKREKWPKRPLIVTGSRDHSLRVWTLPRKGEVEYEFRVNNDPVLDMDADADPSSLVPEHNPDPENAEEDPDAEPDVKENPYHRLHLEGHDHAVRALAARGRTLVSGSYDCTVRIWDIITGRCRWVLVGHTQKVYSVVLDPSRSQACSGSMDGTVRIWSTTTGTCLHTLTGHTSLVGLLGLSPSYLVSAAADSTLRIWDPDTGRLLQTLAAHTGAITCFQHDEFKVLSGSDGTLKMWDVGELKEQANNNSNSVVSVSNAGGAGGVVGVPGAAGGGGAAVGGGGTVVRDLLVGITGVWQVAFEGRWCVSASNRNDVTVLDVWDFGRSNSTAGPETDDDGTGATLGLGLTPDQREDEEDLYTGEEDWVGEPPGGMYDEEWEDGYNTFGGYSDEEEEERDGSDDEDPMAPEFFWKGKGKGKGKERDKDRTGVKGNHALGKTTTTATTNRSKGKGVVKGTGKGTGNSKSSGNGNGNGNGKGKAKKRDDAMDVVEEDNNVNVNDGHYFNVDVDVDVDVYPHDPDANPDADVDVDVDASMDGLSAPPSRNRTRSRSGSATTTTTTSGGVDRDGDGDGDEDVYGYGYGDEDEEDPIEVEVELIPRGESGTGSGSGKSRQHHRINNNNNNKSHTNAAGGSRINTRHSQHNQSQMQQGQGQGQGQGHFGHKRQGSLMRGAGTSAGVGVGVGAGVSAGAGAGMGVTTRRGASVAAAATPVSSTTATPSTGMMSSATINSESQSQSQMIDPDGDAEMESLSGSVGGGGGGGGGGHDSGSGSGSGSGSGNDTPSPGPITGGHGHGYGGGGGVGGSRKRERGEREREERHGGHGHGHATRKRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZH6</accession>
    <name>A0A8H5GZH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZH6"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="613" mass="66401" checksum="ABBEEEF0F92B4EF9" modified="2022-01-19" version="1">MNFLGSGRTSSKTFWINLPHNVFYVVAVENVQMQFNSAIYTRGRHPGPTGSVPVKLTGSKGGIPNNLVYLFSAKTRLQLRGSVLHLTCWRDPDMRHHQQLLVHHEQDFLASKIASLASQHHTSEYSCIKFGPSGCPVRYTPLSLQAPELFAELRHRQVLWSQTKVWWLSDALSQSSPVVLGPSGVLLDAPESMTNGLAQELSEAMEEELPNNGSSIVDPVPVQPSPSIPTPRSHQIKTSLSHPINISVIIPPELIALISSHLLFTSVAESSQNVPTQVPITSSSLPTIFEVPAPFTLDRLLAFPPKNNTVRGPFDPSFSHTVATSTLTRQLRTRTQVSEALQAALNSGIPSLPDTEASCDPSDSYVSSVSVSVSVVTLPPPLSPPPSEAAAPCSPPSSPSTDISPSSPPAFTLGNLLLSSCPGKKVRLQGPVKGRSGVCRDLDADLQRMKELGVGCIVCCLDDTELGFLGVPWAEYERATNRLGIDVLRLPTPEGLSPSLAPADLDRELTSLIQNYTLRGLPVLVHCRGGVGRAGVIACCWIIKLGLCGWFGADSSEPLPESPTTPTTVRTDALHLAEKVISVVRRRRSVKAVETYEQVQFLVDFIEYLREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0A3</accession>
    <name>A0A8H5H0A3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_004734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0A3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034568298" evidence="8">
        <location>
            <begin position="23"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="10">
        <location>
            <begin position="457"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5374351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="672" mass="70335" checksum="6B11E3708ED6FDB3" modified="2022-01-19" version="1">MKHLSALALASVLSFSAGPARAALYTDPSQVPSTSYDFIVVGAGTAGSVVASRLSEDSTKKILVIEAGVDDTGNLNVQVPFFAPLAANTAVDWNYTTVPQAGLNGRSLTVPRGFVLGGSSAINYLGWTVGSSDYYDKIASITGDSGWAWSSMQGYFKKVSTLVPPTDNPDITSDERPTSNGNGPLLVNLPNFNLEPDQRVFETAKGLGSTSGSRFTFTNDMNGGNPLGIGYNQVTAGEGSRTTAATAYLHPALNNRSNIDVVINTRVQKLIKTGTDSNSGTDLPVFGSVEVAVSQGGSKTTFNATREVILSAGTIGTAQILLLSGIGPKEDLGSSNTIVDSPQVGKNVKEHPLLSIFWSISSNASYDDALRNSTIQATDINQWSATKGGLFSATPVNVLGFLRLPETFFNASQPDPSSGSKSPNTEIIFVDGFVPSDTNPLPSTGHFMSIICALLSPTSVGSIKLASGSSDTFTQPLIDYGLLSTDFDVQAMLQTISDSETFVSTNISGSNPFTKDGYLQNLFGDFASAKTEAEKIAFMRAHADTIHHPTGSARMGSQSSGFSDGVLDASLKVRGVKGLRVVDMSVLPIIPEAHTQAVIYTVAERASDLIKADNGIQVSNTSTTSTTSSTTSTTSSTTSTTSSNSAGITTALAHVQALVLMLTLPIILSTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1H2</accession>
    <name>A0A8H5H1H2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1H2"/>
    <dbReference type="OrthoDB" id="3261505at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034586750" evidence="3">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="35784" checksum="0E9124F4E527B26C" modified="2022-01-19" version="1">MTRKLNLTLVVCLVFVLALTSFANADLVAARRNHRMTRKRSPQLVGVGEDPAGVSANPTPSSAAPSSGSSAPSSASSLPSSAPSSAPSSAPSTSASSSASASGLLNLSLSLPSLSQSSSVSKSSSSSSSSSSASSSSSSSSSSSSSSPPPAQTPESSPPALVTEVVSGHVVTLTSTTGPERTSAASELSGAATDNSKAKTAALTTLIVVASCIGGVVILWTVFRKWKLARSSKFDQRLQPIDWQQPTDHDDRDPAALRRRASDTSSFHSGTSHAGYGSDHGHGYGATTLPNLPDHDFTAGPAHLAPVGGYADLARGPSPGPQMNELSRGPSFTRPDYDVGVPLHHQAGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHI6</accession>
    <name>A0A8H5LHI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHI6"/>
    <dbReference type="OrthoDB" id="2995154at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="416" mass="46700" checksum="7AD84D8D3DD1E727" modified="2022-01-19" version="1">MLFGPFFKLHEDIAPNLENFGPSTFQGLTTDFEEKSSFSNDVSANLWNVYIGEARRYDEELLKGWKEDMDGVLLFSALYSASLTAFIIESYKTLQDDPAQNAVTLLSQISLQLSSALNETSPLQSSLDFEPPVSAIVYNTLWFLSLALALTCSLLATFVQQWTRDFIHKTNLRPSPVRQAKALEFLYLGLRDFGMHSFVDAIPILLHVSLVFFFGGLVGFLYPVNRPLTYLMACVLGIFVTVYLTLTCIPLFHLDSPYRTPLSTALWRLKNAIQGSSRLSRSDQTLAAAMLEKSLENSVERDKKAMVYTMKSLIDDTELLPFIEAIPDAIIHSHPDYVYVTNAELLSSLLETSNPEVNIMIRMGQFLVKSKTWTDPSFLARASLACPRALWSLAFMLVQGTNIYARTLYPPLPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHX0</accession>
    <name>A0A8H5LHX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHX0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="26446" checksum="D8EBE5C51A8C15EF" modified="2022-01-19" version="1">MILLDSSFHLQFTGGTAGCVLAPRLSENPKNSVLLERGPVVDCWRSSVPLVSSNFSDQKAPVYKWQSAPLQALNGKQLTMVTGKALGGSTKINGLIYHRSVPGEYNAWQDAGRKNWSWQHVEPFFKKSEDSLSHGTSPSHGTKEPWQNQSTKKDHFPSVRTNIKIATQFGVSLLTEANDPGAPVVACTSLDAAIDRGSHRCSTDAAFLPRSLVSRRRNLDICTRTICTSLDIKDGNPLEVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJL0</accession>
    <name>A0A8H5LJL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJL0"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5359915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="16323" checksum="A7092171D2433B66" modified="2022-01-19" version="1">MYTVILYGVSSITLKTELIGKITGRKIDADALIDSSAEGIIINSRFAQENQLTLLPIKNPFPVRNVDGSKNTMGWVQHYTIQKLRIYSQDNKLYHEEIAEFYVTDIGDHDIILGTDWLEEHNPEIDWSFTRISMSRCPETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LML0</accession>
    <name>A0A8H5LML0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LML0"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5362721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="45515" checksum="4F00E374A3F4954D" modified="2022-01-19" version="1">MSDAGENTRTDVQDTVPTPSLSPLSTPTLSVALSMPENTNPNYVMPLSDINKAFDSLTVLTGSENWYFRVNSTLRVIRHQHFKSSGLHPGNTVKLACFNPITGKIDDKIMIHYIEESDAIELIKKLKQRFDPSSTVQESNELWKLFNLHKTVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYTAVDLIAWLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAVLYQKPSDGKKDRKCFNCNKMGHTTQTCPELWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSQIATTSTSQSDWVQSISSGDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPS3</accession>
    <name>A0A8H5LPS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPS3"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="135" mass="15081" checksum="14A882CB26D99E8F" modified="2022-01-19" version="1">MQTTPGWMKNSRTMNGGSLKSNMLTPYRIGIEEFDEQQWAFHCYGGSVSQQDAFVNAFPNKEVYFTECAGMIGSDWWSNIKWYTDNIFISSLEHSSSTSLMWNITLDGNGQPTLPGTNSCGGSGCRLVTSLLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPT1</accession>
    <name>A0A8H5LPT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_008192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPT1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="103"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5364989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="531" mass="58799" checksum="097F72032A3443AA" modified="2022-01-19" version="1">MIASKRQPFPTHIMIRLQPLTRSKLYILTLGLTFITPIIRAASTLFEGGTVISFDESFQTPVVLQNMSLLVTDDRIAAIFDSDSQGDVVIPGDTERISAEGKILSPGFIDTHRHGWQTAFKTIASNTTLTEYAFRYGEDSPVESNFIPDDMYFGQIVGMWESLNAGVTTVLDHAHGTFSNETSTAYFKGSVDSGARVFWCYAIHDIPNGYSISDQMANFQELAHMNSDISNSTVEMGIAYDGFSTASMEELQSVMEFTRRPHRTSNISALTTHYLGGPWISSNSPQLLNTLNFLNTSFPIVFSHGSFLTTNDALLLRQFNQYLSITPESEMHYGHTHPHSALVQDQAALGVDTHFTYSADMVTQARLWLQSTRLKYYGQVIDQNWKIPSNNPMSVNQAFLLITRSGALSLRRPDLGVLTVGAKADIVVFDGNSPNLLGWSDAVAAIILHSNVGDIEQVMVDGQWRKRDGKLVAKENVNRDEANQQFLKSARRIQGIWKDMALPVLGEDSQTGVPFGMALVQDVVRGNGTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPV4</accession>
    <name>A0A8H5LPV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPV4"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="560" mass="59998" checksum="122871F5BD52355A" modified="2022-01-19" version="1">MASKNVSDYLATDDLTILLGLIAATVFLLQTFNKPQPLVHPILLGRQSDVARVRNPSESAVYRNYGTGLISRFPLRPGKDVHILADFVRSDQDLPRTLWGTKISNSALQDRVAAAGTGLIRLAGLQPGESNVLLFLNDCIEFLISDLALASHSIPSFTLTASNLLSQVLESHPPSTIITNGELLPSLLELIYDGGHNTQKYTIVVVGEPSARAMASVASKIKVLRWEDVEREGNKVEKILSPIPKPQDVFTVSFYDNGNGLQGAQFSHANLTAGVAAINSMFPAAQALSRLDTIVSGHSLSTAYGRAIAYSAIYEGTSFATLASSKLFHVDEATVKHDIADLLSIKKFPIPSPTILFIKPGHLEQLVDAILREAKKSFILNTFAWRHKLAGISEGFVTKDSLWDRLVYDGARARVIGEGAGTVRAVVVGEGPLPATVLTPARVALSCPIINTYTHPLVPAPVLASHPLDLQAFPTSNEKEPAASGPPSVNVEAKVVGVSDEVIEAGGDPEGLLLIRGPPVGRQGGVEESYVDVRKLEDDGWVATGARARIQTNGAFKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQC4</accession>
    <name>A0A8H5LQC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQC4"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034962340" evidence="3">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5365618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="288" mass="29810" checksum="58DB250076C5E9B5" modified="2022-01-19" version="1">MFSAVVSAALLALPLTVVADQHHHRAHQHRDIAKRAPGNVNVYKRFDGTRWTFYDVGLGACGKTNTENDFIVALNTPQYGSGFPGPNCFKSITMSYNGKTTNAVIMDECPGCPYGGLDLSRGLFKFFAPESEGVLTGNWWFNDGSDSGGNGGGNGGGQGGGDDPTSTTKQPKPTTTKEPEPEPTPTTTQEPPSPTPEPPKPSTTSTRTRTRTSTSQTSSSSSSSSEAPSSTSSSSSSETPSTAIDYSSGPASGLAVPTGTARSSDFLNVANQAIINLGGVVAAGVQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRD1</accession>
    <name>A0A8H5LRD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRD1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034380018" description="Cytochrome P450" evidence="8">
        <location>
            <begin position="26"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5366591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39473" checksum="D957BF8B69A571C8" modified="2022-01-19" version="1">MHDYLWMCLWHLYCLFKLISKEGTALWDDPAQCFTLDAIGSSVLGHNFKAIETDNLFLKEYNQVMAKIAAPLYLLFPWMERLVLWKQLICCIDNLTSKFIDLLEHKRDNPGDDMMTYMLKDPGMTFNKLRDNMIVLFLSRHVSNISDAIVTTLNSNKFQDTTAGSILTLFYFLVCHPEIQQQVRDEVKWVFGDDQNPTVDLISGISLPYLTTCIREALRINTAISYIFPQKSPQPVHLGKYTIPTETSLIMNISAIHHRQDAWKSPHDFDPDRFLDPQWSKSSWLPFALGPRQCPAQNFAMYKQHILASHVSVGIQMGTTSQFHSSQWNPEFLFTFCFDSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT23</accession>
    <name>A0A8H5LT23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SLY1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT23"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="79542" checksum="2AA5F521D7D277FA" modified="2022-01-19" version="1">MGIGPIGCRERRVVSVFRVCHVSTYKEFNRLLYYVEALRMSSTRQHATPSTLQQSQTAALLSLLNLNSPPDTSNTSIPSGKQSSGIKTPPVSGPPVWKILVLDQQTKDVLATVLRVQDLRDIGVTLHVQLHSSRPALPDVPAVYFVSPTLSNIRRIAEDLEKSLYESFHLNFVEPLPRSLLEELAATVARDGTGELVQEVMDQYLSFIAPSPSLFSLLPPPLQAVPTSDAASPSSSTIPPSTYAILNSPSSTEQQIEDEIERIANGLFSVVATMSHVPFIRCPRGNAAEMVAKKLETKIRDALLTASRSHTSSLFSQDATGLSTLQRPLLLILDRNIDLVSTVSHGWTYQALVSDCLEIKLNRVVISQPQKRSYDLDAKDFFWGRNAANPFPQVAEDIDAELNKYKQDAAEITRSTGVSDVNDIAQLDLSTNAAHLKTAITQLPELTARKATLDTHMNIATALLEQIKKRGLDELFSTEEAINKQTVASILELLRADRADGNFTAEDKLRLVLVFYLSSPDNAISKDDISELEKELKSAGADLAAFDYVRKTREISRMTMSTALGGSATPIGGSSSQGGELFKGFSAFGNRLTSQLKEGGLENLISGVKNFLPANKLLPVTRLTEALMDSSVASNQSLQETDDYLFLDPRAPKHAQAGMPGAAGGSGTTKGRRMTFAESVVFVVGGAGYVEYGNLEEWANKTGKRVTYGGTEILDPGGFVNTLEWLGKGGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT39</accession>
    <name>A0A8H5LT39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_002436</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT39"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="92"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="256"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="554"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5368513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="688" mass="77563" checksum="2BF3AF86E11636FA" modified="2022-01-19" version="1">MTRIVARLFKALKSLRTLLFTVFFVCFSYFLFSDAYLKLSLNHVHNLRVVWPFSDRNNSEAEGQKDSRFTLSPELHSYREPRTVTYDFTLEKVLVEPDGVKKEVLAVNGLFPGPTIEVRSGDELVVNVFNGLGESTSLHWHGIRHTKGSVSQDGAVGVTGCAIPPGRNQTYRFHIDDEQSGTFWYHSHYPTQRADGLYGALIIHPPFEIDIIPANDTKSKGPLPGELKLRVPTGIPMSRVYGRNSADESSRNMTKDQVILLGDWYHRSGKQVFDWYQSLRSAGKEPVPDSTLANGMQASNCTKLQALVKSIECREAAYPRIMVDAKKRNILRLVNVGSQNSLHFSVDDHLLRLVEADGTRIDPVVVKEVPIALGQRYGLELIPNAPNVKEGSVFWARYHLDMDNMPYPCVYLFSLFSIPSNLNIASDRNPLLDLQPKAILQYSSKSKSTQITPQKLPETQFWNIPESEQLDPLTLLPLEESQRVLPPAEDVVLIYVTSMTRTSTGGKPFGYVNQTTWKPNLQEPILARPSASLDEESPTELIVPIRSELESTPNSSSSSSNSTPWKNGKGKVVDIIVNNLEEDPHPFHLHSHHFWPLYTFQARIGKGSYRWDRPPSLPTTAPALRDTFLVPQRGYAVFRVLFDTPGYWLFHCHMEIHLSSGMAMIFDVMGDRISEEERKKASGTCQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT99</accession>
    <name>A0A8H5LT99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT99"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="58610" checksum="43C6E92341BA7791" modified="2022-01-19" version="1">MGCIRPATPGFICTLTATILLAIVSFCVPYFKSVFFLEANINVSGVEGKITFGTLGYCIELSSGTSCSSPSVGYSLDINGLVGTNFPDNIQIPQIAVKWLTYALVLHIVALALAGISAIFGLLAHVREFGNSCLSTCVSGFAAAVALVAFIFDIALFFIAKARINAVGSASIGNAIWLTLAAWILLTFSGCFYTIGRCCLSSRKPRNDNRLPQEPYHEQMRLDAVKLEAERKAAQKETGLPAFHESQPLTGHVEGDSVYVDSDTHNPQMAGYGRRPSQGGGYVGGGYVQAPSGTRAVDEYYNPTQPQNTSAYPPHPQRQASSHSYAPQRHGSSHTYAPSNYAPSTYHNYNTPQSPPPVPQVPVGNQYLTIGQQPYPERHGTPGREYGHAAGGTSYYSAHEQHPSSYSPYDQAHYDQPRQDSYNYNGGGYGSQATSYYSAPATTPGTGPERNYTLGGDGYGENSVPPLPERQGSVPALPDHPAASSTYNIPYSGSPAPINTNLPLSGGTNPSPRGPRQQPTTSSPTHEDSPPGYEAGTSGITGAWGKGPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTV9</accession>
    <name>A0A8H5LTV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transport protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTV9"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19565" checksum="5018F749F4A227E8" modified="2022-01-19" version="1">MSHHLFILSPSDTPIYSLTYSSTKPAGTISSPLSSNLPTWSTSAFAGTLTALSGASSQTQHTSGGGVRIGGGQDRHVIQMIANASLDAVEDVMRKENTMYLKSVDKFNEWTVSAFITPGNSKFILLHEGKNDEGIRGFFMEVWELYVKTMMNPFYSAQRTVRSNVFDGRVRAAAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUT3</accession>
    <name>A0A8H5LUT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUT3"/>
    <dbReference type="OrthoDB" id="2685795at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="255" mass="28959" checksum="BD72E401592034C9" modified="2022-01-19" version="1">MRKQSRKNEYDGEGNDVKAGHKIVDREEVDTLAMTSMVQTDSRISVIFVPNQYLYSLVQHRQLLIFSSDNVLLRRNNRSRCLFYAVRPGSTICIENLPAFNSNDPVAYTQPPNPGWKFGMKVEETEEGRKWIGGEKQGWKRVDTEGEDWMKVYQLMLSGIQPRPIALVSSVSENGVCNLAPFSWFNAVAFFPPLVSYSAMNMTWETDGTSKFKDSVENVKATKEFTVNIISIPWAALNKPTLLLSIPLMMYRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYB1</accession>
    <name>A0A8H5LYB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_000688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYB1"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5373839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="310" mass="33585" checksum="5B454B398F02FA57" modified="2022-01-19" version="1">MMNSFADRFSTTGPIAELRKAQANVEDDQFSDAAWGSEAGFGSLAKGVPAFTVPNVPDPSAFLRLHTDDHADPNCRIKIQHGTTTLAFRFQGGVIVAVDSRATAGSYVASGTVKKVIEINPYLLGTMAGGAADCQFWETYLGMHCRLHELRQRERISVSAASKYLSNLVYSYKGMGLSMGTMICGWDKTGPAVFYVDSDGTRLKGDLFSVGSGSTFAYGVLDQGYRWDLTDEEAQELGRRSIYAAGHRDAFSGNTCNLYHVKEDGWRFIGNYDISQMHYEGPTGTGTGYGYDLRVEGRTSANPPPAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ86</accession>
    <name>A0A8H5LZ86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ86"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5374826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="395" mass="43476" checksum="6FBC7770E667D297" modified="2022-01-19" version="1">MLLYETRLPKFSMYCPSCFYFRLGGISDGSLITAPTPRNNTTSSMEIRENNLQTTMPITLSPSSSDSRKFKVAAVQAEPVWLDLQGGVEKTIRIIREAAAEGAKIIGFPEVFIPGYPWTPWSNTFVEAAPVLKQYQANSMALHSPEMERICEAVKEADVNIVLGFAERDGASLYIAQVTIGQDGTILNHRRKIKPTHYEKTVFGDGSAQSIYNVVQTPYGRLGSLNCWEHIQPWLKTHFYAQHPQIFVGGWWPAFPPHLGNSPYIVSGEASSRMTQLVSMEGGCFGLVCCHVVSEEGAEKMKMKGFPWFQFPGGGFSTIYGPDGSTLAPPVDPGTEAVLFDLLHTVVNGKNWAPARYPGKEEAEADVVKQNEVPNAANSFSYKANLPENGAQGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZE2</accession>
    <name>A0A8H5LZE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZE2"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5375157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="482" mass="52926" checksum="1CC7CD5F97A82768" modified="2022-01-19" version="1">MSTDVAALKAEIKSWERSFKQSHGRHPSVQDIRDNPDIAAKYKLYKKSSKTQPQPSSSSIPLSRPVESIAPLSTFNPFSPRKDKGKQTQLSPTKKPFANPFATPSKVKPVPRIQNSPSPPPSPTPEPKHASALIRSPPTAVSRARKRLRGEPVSPSPNKEKRRRIESQTALTFGRRNTEALDSDEEDGNEDHANSSFVDDSPVKPSTAAKSFHILFEEASGSKALFSRSKSSGLFASLSSTSAEVEDDLDWVLGDKSKAKRRQDGVSSEAQSESSSGQRSSMKRSLSDSDTEMSNEQESNEATASDLVLVPPSPPTEPSSHRPPNDARKRNNVRKKAKLGDDSDTDMTSGDEIKVVVKPQLRVNHAEDSALGLDSEPILRYLRPLDSTTTDIQSDDNQGALDVQLPDKLRDILALSSAEPKTYHPPEDQVVEELIYGRKTAHYDPSRGGEIWGVGDSEHGRNDAEDEDDWEGEPVPWEIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZG6</accession>
    <name>A0A8H5LZG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZG6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5375232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="42912" checksum="1B62A8F23560C218" modified="2022-01-19" version="1">MFQNASQDASYYHPSPLNKQDVWLDDDYSLQPFHFQSYPCPLSSGPLGLQTSYSDIDRNTPSDFTASPLSPLESLESFHTAPYPATDFLNTANVAGATSSSLFSMPPPDPSFQPSSDYFASEADNYDYLGGASEPSSFNDETQQYSSPIAYSPYSPHSAYPAFPPLGSIFTQQHIGQCRTVEAHEAHHAVPVRTEPSEQSARMIRQSDAPVLPLPMSLTYDNTTASTNCISEAESAYLHPSLSGSASSNLYPQLQSFPSLQSSYLHPPLPLLCLPLSSNTIAPSQTQLTKPVSIHPSSLSIITAGTGAEPQNPEIEILAPRPTRPSRIAPNALKNLLLATSTANADRRFAKNAATDATKAVTLLGNPCNGFATGTGLVSVDTGTQFGHIDTGMGGVMDCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZI4</accession>
    <name>A0A8H5LZI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZI4"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="10">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="20764" checksum="97043310F1786C17" modified="2022-01-19" version="1">MAKQIFSISCINVGVGPGGTTSMLARIAIVDYRGQTVLDTYVAPTMKVTEYRTAQTGIEPGHLHGTNAVPFNAVQQMVANTIKGQILVGHSLWNDLSGIPHPAVDTRDVALYQPFRNALRSPNHIVGLQTLSWQLMCRRCQEGEQNPLENARAALDLYRSDLRDWEDAIVKGSWPCALPPSIFSRCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B7X9</accession>
    <name>A0A8H5B7X9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_018544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000458">
        <property type="protein sequence ID" value="KAF5318213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B7X9"/>
    <dbReference type="OrthoDB" id="3265672at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5318213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="363" mass="41183" checksum="48D673C92D0741EE" modified="2022-01-19" version="1">METRKNEWTMLFKPSRKTPNGPSVPLRNFYQVPRATLGTRLKGVKPRTEAHEHQQNLSNAQERVMVEWVKVRARRGVPMSLALLGSYAAHLCGRELGAMWPRRFLDRHRDLKLKLTQSLEACRAKALNPKNVNDHFDLLESVIADYNIEPEHIWNMDEKGIQLGIGKRMTALVDRDQKSVYSVQSGNRDLITIVEAVSATGERYIPRMKRDLRWAENNPDNASISISPNGWTDQELGSLWLEKDFEPNTRPDPALERHRSIDIDKYNLLFYYATAHGGAFRMSTIVSSFAKCGIHPLNRFIIPPEMYEPSKITTTKSALPIAPRFPTFLTPVLDPSPSSASDDPSEDLALAVTGLRLELLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BC84</accession>
    <name>A0A8H5BC84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000414">
        <property type="protein sequence ID" value="KAF5320221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BC84"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5320221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="133" mass="14305" checksum="784613837494EA05" modified="2022-01-19" version="1">MDSRREEVGKEGVGNGKGGEDMAMEVEDVDMDVAQELGFGFGSRFGVAKERTLVSMPDLDPYPWVFATMLLPCTPAAPLAKCGHGFGDGVGVGTDLVKVVVTIVTNTAAEGYGSTMTVSYKFFFHSRQYSYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BX03</accession>
    <name>A0A8H5BX03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000336">
        <property type="protein sequence ID" value="KAF5330068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BX03"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5330068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="32563" checksum="8D959C9D25C7E17F" modified="2022-01-19" version="1">MLLGMCTSRLVVPGGVAKLIVGAISSLLKLSAIITPARVIRSCAGEGEREVEEVLGPVGVDEGTCRAVAKALRWSTAFLLKFGQGLEEVPISRLYISVFTIGLGYLIGGLVPLFPYFFIPEASTVLIYSCVVMGVVLLVFGAIKAQRIGCCSDADPSARMSCSNMPIRIGGWHPSDDPIIRGWNGSGHLANIFPTYSQLRAKGSRCSTCRKDLSVDFTHPTIIYGWADGIRRMGASPEAHPPSESEASSADRRRIIRSVRSPTLACTSNSTLGVWKGIVWGAVSTLLVGGLAAGAALGIVKALEGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C227</accession>
    <name>A0A8H5C227_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000286">
        <property type="protein sequence ID" value="KAF5333782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C227"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31336" checksum="6071C43207699559" modified="2022-01-19" version="1">MSTESQAVYEAIGKNQGEGQRLEEQYPLFKKYIRKDRVIFDEAVTLGDNAVVLDVGTGAGLNIVHGSSILLKPCLPPSPSMLSTPPLPSSPQSIPKTSFFAKHSGTALPQTWTNKFDFINQSLLAGCLTRDDWIQDLQELFRVTKPGGHIQLFEPSFESWDCPPNSANGKMKSMYKVLFDNTSLIYDLGVKLPHMLLDTGFVVVGQHKSTFPVDTNDGAPVQQCVGMMIRWLRNLQPPILRFGLLGSAEEYESLLKEMQEEWNHGVPTENFFVIHARKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2E9</accession>
    <name>A0A8H5C2E9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000289">
        <property type="protein sequence ID" value="KAF5333753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2E9"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="212" mass="23973" checksum="F89FC116BF9BD4E5" modified="2022-01-19" version="1">MSNLELLQIRQLAGHSESRYSGRSANALCRRRNDGLFLDRSRQHSTCSDCSVQEDIEKEMVDAGLIPPPQPALSTLPLKTENPRDSTVLISLNSRSGKNAAVDEEEEAIRTRLEAIELHVGANFAERLCWDRSLFTETLDVIKFVCKDLWAACWDRQVDNLRTNHRLTKSIQGIYVLQDNAFKTITRLSSWEGRADATRKAKLGSNSVHDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3H7</accession>
    <name>A0A8H5C3H7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000261">
        <property type="protein sequence ID" value="KAF5334354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3H7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="351" mass="39661" checksum="3451906ED268B799" modified="2022-01-19" version="1">MDDGLLQEISSFISLSTQILQCVGTLADASRAIVFSFLVYWLVVKYCNFFSEMQARSPFDSWPFLQDVAGSTASDSSATNTASQCYEARLMDSFLHTLFLVNSGPRYRATRGVGPHFPRHWMLGTSSTGKAEIASIVAFHWNENGSVTLHVVRAAGQQQQLCRPYSKSTLQTKSDEEDSKAFQATSSTFNNAQTINITTVNLNGPNVMENATATSVPADVLEQRLAMMKERLMQVEIENLKLRNQNLEFRMSQLEQQFRQRIPPEPPPVSVPNRDQCHSSTTFHSSFPNSSSLFSFSPQTDISPSPRTLNDEEPSDFWLYLYLFCYFFLVPVLLLFLIRCIVTPAIDWVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3T2</accession>
    <name>A0A8H5C3T2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000253">
        <property type="protein sequence ID" value="KAF5334712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3T2"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="539" mass="59676" checksum="744976A6C859A72B" modified="2022-01-19" version="1">MFWKTPYTKFATLSGPQNAILSVSFSVDGDFVAAAGYSGVTIWDLKTSQAVPTPHLPYEPNERKHVHCSSAWLFFEAGEKHVFIFGNMAGQVTLWHWDGHDHQMFRVSGNQSVYRNEPEKVMSMDVLQARVPADKDTFFVTSTNDYSVSVWKLDSSLELSNVFKVDLPPDFIPRTVQFSRASCTVFAFSKTGGSFLQLNGKSGELAWIKKEGLKRMDSVALDEGKDIFAAWTGKHAAAFRQSDAEHITTFRNEGCYVANAKQIGFAEEGSTVVVGTDYSSAEVFSLDTGRRVQSLPYPGRSLVHYIATLTLPSSYLVAIAGSTKSQPAQVVIFTKKRFISKPGSFLHPSEYIGGRGWIAFICFMLAVFCIVFFNYYPNFFLFGIEFSVNPLGLGLHGFVYIPCLSKYMWSWQNSNVIDAAVIANLASTVTVIEPAFSTVTVIEPAFFTVTVIREDFVTVIEQVTHTVFEAVPVTFTFTSATTIVPMCPTVISTISVTKTHLDEVDNVTETIAPTVINTMSVTKTHPDEVDYVTETVHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C517</accession>
    <name>A0A8H5C517_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000269">
        <property type="protein sequence ID" value="KAF5334117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C517"/>
    <dbReference type="OrthoDB" id="4230923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19926" checksum="188B4B24FA35723F" modified="2022-01-19" version="1">MLRELEEMNHIPEGSIVKTRWCNGTKDGKKYLGQHVAHLYLYITTPETANRLVINGLLAEGARCPMERKILEDPRCFHCNEFGHISQNCPQHGQEGGDIPICGNCGEGHDTRQCMNSEHTYCVNCKTDDHSSRDRSCPTFQQCCSNRNKHQFTNALPFFPTDEDWTWATEPTNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C5Z9</accession>
    <name>A0A8H5C5Z9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000234">
        <property type="protein sequence ID" value="KAF5335895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C5Z9"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5335895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="35584" checksum="666CD2A34AB585CB" modified="2022-01-19" version="1">MSNINTNTSFAVLGSNGAISPFVIDALAKHSGVKKLIVLSRPRPSSSSKPSNLPANAELVAVDYNNHSALVEVFTKYSTDVVISTLSDAAIFDAQKKAAVAAREAGVKVFVPVEFGNVTIGLAGKGERNGEGEGEDDIQVKKNRFAEFLKSIELPYIHVFTGLWLRWISWVFGYDVNQKFNIIGKGETPASFTAEEDIGGFLAHILTTLPLSQLSNTHFRLQGERLTVRQIADRLGKPYVTNVEAIPGSGPSDWKFRTLITSQCDSGVGSTGWDHFTQKDNPGPGPNPMSGKGEGEGQGKEGKEVKTRKPRGVGINFGKDMFGRGWRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9M7</accession>
    <name>A0A8H5C9M7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000205">
        <property type="protein sequence ID" value="KAF5337815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9M7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5337815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36648" checksum="2BEAF1C7C8428148" modified="2022-01-19" version="1">MGSTLSLLRETFPPKPKWTTNDIPDLTGKVMIVTGANTGIGKDTVKALLEHNAKVYLGARSQAKAEAAIEDLRQKTGKEAIWLKLDLADLKSVKAAVEEFSSKESRLDVLFNNAGVMGPNFEDLTAQGYDLQWGTNVLGPSYFASWSINAISYRVLLSSIGHFYLTKLLLPILISTAEKNPDGKARVVNTSSSGHHGCQKLDFNTFRDSPARKKLGSFPGLYGQSKFGNILFANELARRYGDQGIVSTSLNPGNLSTDLARTMSKAFKIVIDLFLYPSELGALTQLKAGTSPEGAEMNGKYLVPWARVGKPSAATEDQKQSEELWKWLEEQVEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA39</accession>
    <name>A0A8H5CA39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_015852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000220">
        <property type="protein sequence ID" value="KAF5336802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA39"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21220">
        <property type="entry name" value="CH_PLS_FIM_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="112"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="260"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="387"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="538"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5336802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72260" checksum="DBFD7BB03B7FCBBB" modified="2022-01-19" version="1">MEALRLQKKYPEVSRDEMFELINRFNAISTDTPGRIDKQAVLQALQASGESYDEARETLKHVSVDASGKVELEDFVELNVKLRTKAKSAISTKAGKVTVQGSNANVSHTLNEDERSEFTNHINLVIENDPDINHRYPIPTDTMQLFDECKDGLILCKLINDSVPDTIDTRVLNKPTGRKALNAFQITENNNIVITSAKAIGCSVVNIGSSDIAEGREHLILGLIWQIIRRGLLAQVDIKIHPELYRLCEEGETIDDLLRLTPDQILLRWFNYHLKAAGWKRRVNNFSRDVSDGENYTILLNQLKPDQCSRAPLQTPDLRTRAEQVLQNADKIGCRKYLTPSSLVSGNPRLNLAFVANLFNTHPGLEPLDEQEAKDYGAVEDFDAEGEREARVFMLWLNSLNVEPGVFNLFENLKDGLIILQAFDKISPGSVIWRRVSKPKEGAGAALGAYIAGGDGGEEEEDIGVTANQSKLTRFKSVENTNYAVDLAKQHGMHMVGIQGADIVDGAKTLVLGLVWQLMRLSITKTLTSLSQSSGGRPISDTQILKWANDTAQKHSNIRPLRSFKDPSITTGLFFLSLLDAIRPGIVDPALVIDVGENGEYEDRRQNAKLAISIARKMNALIFLVPEDIVDIRPRLIMTFVGSLMSIAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA59</accession>
    <name>A0A8H5CA59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000207">
        <property type="protein sequence ID" value="KAF5337773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA59"/>
    <dbReference type="OrthoDB" id="2742740at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="102" mass="11650" checksum="527F6492633A17F9" modified="2022-01-19" version="1">MNKSWMRAHLSNNKVHICASMRLLDPSQNTENQTRSQQILGHASLNSKIEPMSEEFVAQLLNPPEEMLLLSDPDHRLSLDIYLATTHTSEDTYTRVCTAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAB2</accession>
    <name>A0A8H5CAB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAB2"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="23186" checksum="D7FE7435252B3338" modified="2022-01-19" version="1">MSASSAQGKKDLHTVHQMTQSSEGSLPVNFGVVIFPTFQALDVFGPLDALNVLSRSHHIDLSIIAQTLDPVSTKYRDPSVNPLNSNFGESVVPTHDFSNAPPLDVLIIPGGLGTRAEDLDSLIDFVRKVYPTLKYVLTICTGSWLAARAGILDGRRATSNKRSWSQTKVISPNVKWVSHARWVVDGNIWTSSGVAAGIDATLAFIEEVFGKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD70</accession>
    <name>A0A8H5CD70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000183">
        <property type="protein sequence ID" value="KAF5339647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD70"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5339647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="375" mass="41962" checksum="983EB13A22EA50C5" modified="2022-01-19" version="1">MPSDRQSAFQPHPKPPTSLGVLRILSSRAGVRVSPLVLGAASIGDKWNSFMGSMSKEDSFKLMDAYFEKGSNFIDTASNYQDETSEQFIGEWMEARNNRDQIVLATKYTTCFKVVDPDIKQTTNYVGNNTKSMHVSLKHSLNKLKTDYIDILYVHWWDFDTSIEEIMDSLHNLVGVSDTPAWVVSQANQYARAYGKTPFAIYQGKWELTVRLALAPWNVIGGGRLRTDEEEERREKSGENGRSAWGSDWKRTPEEVKISRALEKVAKKVGVKSISTVAIAYVLHKTTNVFSIIGGRKVEHLDQNIEALDVSLTDEQIKFLETEARSFDPGFPFTMIGDGTNIFRLLAAGTYFQRQPYPRPLGPPPAVGPDVVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFG7</accession>
    <name>A0A8H5CFG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_017639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000173">
        <property type="protein sequence ID" value="KAF5340815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFG7"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="156"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5340815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="568" mass="64428" checksum="DA6D07EDB42C6BB9" modified="2022-01-19" version="1">MTPTAVNNPNPSRLEYMIREPVAYLTIWSNIKNPDSYAFPSGQNSYELWSHLQQEYQAVSPLARQRKEDAFNSCRYTGGKITGEGGYVEKFRQLRKEATDFGAVISETQFLTKFIDSFPRTPEWNIITGNLLGETNFNVAANRLQEYEPYPDSTEVVTDPLDLWVLDIWGPSRIPSVGGCLYAMVVVDAGTAKRMSDCLKNRTAETTLQSLNEMKTVAERQTNHRLKRIRTDNAPEFRSNLWIDWFKQHGIIHEFSATYSSSSNGLAECAIGILTAATRTLLNEANLGGRCEKGYRGIVHDVRPFPNYSGLQLRVELQKFGIQVCPSINLDYDHPLDDIDPLRHYHEGYSLRPGYCCMPCEVPYSPECWPAPINVPRSTTPIPSDVNVDSLNTAAAPWTPDQYDSQPEITNFYKHWILNPRLNGLTLEVSLLEPKAKAWVHVSDGAIFNTHRPRLGVVPANICGPLQWPSAHTEQGLMVIIVGEHTGLLVRRVYYCVVGGESYFIVRGVDFTGSDRQERMTNTQLVLHPSWLIRVMESKADKERGKKVFEAIRKEARRRKPVYLQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK02</accession>
    <name>A0A8H5CK02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000148">
        <property type="protein sequence ID" value="KAF5343144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK02"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="288" mass="28072" checksum="9E29153EFA16132A" modified="2022-01-19" version="1">MISGSTTSSAHETSPTGTAGGASGQDMGHIIEQLCQNQTTKPPVTDKGKRAATPIVSSPPDGGKDGSEIQQLVNKLCTVYHQQHNGPEPVPQGTNGPSSGSSPSGPANEKRAAPASEEQPSDQSNSTTGPGSEGPPHGHSKPGGQGHPPQGQGDWKKLLEQLCSHTKGQGQGGTSGAPGGPEKGGPPSDSTASGDSSPTEKRAATSGGPSGHPGSGPNGHNGDPLEKLCSMMHNKGQGNGGASGSATPPSTNPDSTGNPEASSGSGSPAGSSTSTEASSASSTDSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLH3</accession>
    <name>A0A8H5CLH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000149">
        <property type="protein sequence ID" value="KAF5343111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLH3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="110" mass="11602" checksum="B794735BA3B0D9AF" modified="2022-01-19" version="1">MPKSGGVVCSQENLIISPLHSSLERLKGAESFIESLRSYTMRITGISVPSVAAITFITMMLMLTTDVNAAVAQVDPSDAACTLEICVGSPAVATQAPAEGDTVDWFPQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLJ9</accession>
    <name>A0A8H5CLJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5343984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLJ9"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18805" checksum="03047419C6045C4A" modified="2022-01-19" version="1">MSAVTCNQQVPLITLKTELIGKITSRKINADALIDSGAEGIIINSHFARENYLTLLPIENPFPVCNIDGSENTMGWVHHYTVQKLCIYSQDKRSYHKEMAEFYVTDTGDHDIILSTDWLEEHNLEVNWSFSKVDMVRCPETCTLEQPPVLNLCTKPKPLKLTVANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMP8</accession>
    <name>A0A8H5CMP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="5 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_008914</name>
        <name evidence="19" type="ORF">D9758_010080</name>
        <name evidence="17" type="ORF">D9758_019013</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="5 14"/>
    <dbReference type="EMBL" id="JAACJM010000647">
        <property type="protein sequence ID" value="KAF5309326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMP8"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5309326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5344094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5348089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="361" mass="40392" checksum="0A36071CAAF436A4" modified="2022-01-19" version="1">MYTSRYDTVLDIYTSTNHLPGEDTERAPVWIMRQAGRYLPEFRKVREDHGFFEICQTPELATEITAQPIRRYSGLIDASIIFSDILVVPQAMGMEVLMNPGPQFPDPLNTPEDVQKLKTVVDVNKELGYVFEALTMTRKELKGEVPLIGSAVLLGHCSRGGTKTFQKCKTWIFKYPEESKELLGRIAEVCVDFLVGQVKAGAQLLQVFDSWAGELSSHDFQEFSFPTLHYISQHVRERLKANNLPIVPMTLFAKGANTSLSFLAQNSGYDVLGLDWCIDPAEARRIVGDKVALQGNMDPMLLYAGKPAIESAVKRMCEGFHTGKGGWIANLGHGITPGVDPDDVRWFFECVHKYSAKKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN05</accession>
    <name>A0A8H5CN05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN05"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="249" mass="27487" checksum="D00180E4D61B3890" modified="2022-01-19" version="1">MSVLGLVTPNPSFMSSDSVQTNDDVNTNVKANTDDRLGRTEDDAEANRVGERLGLGIEIGIERAEERQTEQNMDWDDDEGQDDTRNTNLHLLSSDSSPSFPVLRYAELALTLNKNPPSPSPSTQPRYSFFLSCQTLSDSCDDCVYSPPCHHHHHGITLILVLVLAFGLSVSFQESTPSGFSSESTFTSTSIKNPNLIYAKACSSRFLRCSGSFDGDDNPHPSYIYLPSPLKAKPKPRRSREGGLTRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPM8</accession>
    <name>A0A8H5CPM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_011871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPM8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5345741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29696" checksum="E58E861F07DC8328" modified="2022-01-19" version="1">MASFKCHAKEWCKDVSAMPILTFDFVKDTMAKGAFIPSVASQCLEKLAAEYPNEPDSSCRRPGAEKLLSNVLGTIPFQFFDHEYMVKLALAGADTMVSALGSFIFGLVKNPDAHRKGQLAVDELTGGERVPDFLDVGSLPYVDALLREALRWKPAYPHKSIEDDSYNGHYISGANGWAMLHDKATYGPNPHLLNPGRFLKEDRTLNPNVPFPDPAFRFGRRMCGSREFAVASIWISITCIIAYFDVTKVMDEDGNVIEPSGEYTSGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQZ9</accession>
    <name>A0A8H5CQZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQZ9"/>
    <dbReference type="OrthoDB" id="2993818at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57045" checksum="7B0077230ABCE99D" modified="2022-01-19" version="1">MPGFNSIQLGSPIASITAVYLTLVMYTVEVCLSFNFIRRSLRSISGSQRSGGKEMIMRLFFRIPNIFLGLGVMVDTVCVVAICAHIAYAFAGFPIQIKIWTIPTFAVATSLSGAIEHAYFIHRYWAISHNKITTGGLICCTTTHTLFPIIAVAVLIADEYEIRPTLLPDSIRISAALSAFTDIAVAIVTLWTLRSATVIYDSTRSLLRRFSILIIASGCLSSTFTLLLLITSIVNPDGYAFIYLSLGRIYTLTTVINCLLMPKVRASSSSSSDDDDSDSEIERTVSLSVFSPSGPGRGRRRGRSGHRAERERRSKSRSNRNRERDCGNGNGEAGGMKFTSHVMSYPRAQILSSHLDPITKPSGHVPAFSIDSLTGGMGTGLAMDRLYLSRDDSASDSATSVPMSLEGFNQLELERERERERERRPGSDSDSRYRLSLTTVQSLSTTRAATESNCGGGEGEGEGCVSRDRELRERYMSRMDDKDSLEHEHDLGCDVDVKGLDSDLTREVTGVELSASTKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRF8</accession>
    <name>A0A8H5CRF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_013227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1205"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1250"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1296"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1326"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="118"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="832"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5346654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1477" mass="166528" checksum="C59FB720670EB1EB" modified="2022-01-19" version="1">MSDLESPKKDQVITGAARIHDDDSSGVFNPQAPEEVTALARRMTSSSMRDRNPFNDHDDPTMDPRSGKFDYQKWIRSVLQITSRDPERYPQRTAGISFTNLNVHGFGQSTDYQKTVGGVLLDIPRAIIDFLGRRRQRIDILRNFEGLVKDGEMLVVLGPPGSGCTTLLKTIAGETHGFHVDESAKINYQGVPWKVMHKDFRGEVVYNAETDVHFPNLTVGQTLSFVAKARTPRTRLPGVTREQYAEHMKSVVMAVFGLSHTENTKVGNDFVRGVSGGERKRVSIAEVALSGSPLQCWDNSTRGLDSATALEFVKTVGLSTKYTGTTAVVAIYQASQSIYDLFDKVTVLYEGRQIYFGRTEDAKEFFVEMGFQCPERQTTADFLTSLTNPYERQARPGFENLVPRTPDEFARRWQESQERQCLLKEIDEWNAQYPIGGEQLDKFRLSRKSTQTKGMRTKSPYTISLPMQVRMCLERGFQRLRGDSSIFLTTVFGNAVLGLIISSIFFNLHFNTDSFFSRGALLFFAILMNAFSSALEILTLYEQRPIVEKHTRMALYHPIAEAISSMICDLPAKTITAVVFNLVLYFMTNLNRTPAAFFTFLLFSFACTLTMSMIFRTIGASSRTIHQAMTPAAIIILALIIYTGFTIPTKYMKPWFRWLNYIDPIGYAFESLMINEFYGREFPCSLFVPNDLGGLLPQYSNLTGTQRVCSVSGATPGDIIVSGTEYLGKTFNYTKSHEWRNLGFLFAFMIFFCFTYLGATEFISAVKSKGEVLVFRRGHEPKQPKRRSDDVEMAAKGERNSSHSQETLRGGKDEDGVDQRAVVNMQKQTSIFHWEDLCYDIKIKGEPRRLLDHVDGWVEPGKLTALMGASGAGKTTLLDTLASRLTMGVVTGSMFVDGHPRDSSFQRKTGYVQQQDLHLQTSTVREALVFSARLRQPRDTPDAEKVAYVDEVIRLLGMEKYADAVVGIPGEGLNVEQRKRLTIGVELVAKPQLLLFLDEPTSGLDSQTAWSICTLLRKLANNGQAILCTIHQPSALLFQEFDRLLFLARGGRPVYFGDIGENSQTLISYFERKGAHPCLPDANPAEWMLEVIGAAPGAVAARDYADAWRESDEYVKIKKELARKRELAKVRPAVDSETKRKSPEYAEFAAPFMTQFWRCLGRVYQQYWRTPSYIYAKTTLSSLTALFIGFSFWKADNTSQGLQNQMFAIFMLLTIFGNLVSQIMPHFVVQRSLYEVRERPSKAYSWKAFMLANICTELPWNAAMGVIIFFCFYYPIGLYRNTFDDGATTERGALMFLYLLWFLVFTSTFTNMIIAAINSPDEGGTLANLLFSLCLVFNGVLVGPDRLPRFWIFMYRVSPFTYMVDGMLSIGVANTRATCSDVELSILDPPSGQTCWEFLQPYIDAVGTGGVLNRDATSSCQYCSLTDTNSFLSAVSASYEHRWRNFGILWVYVIFNIAASLFLYWLARVPKGGKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRG1</accession>
    <name>A0A8H5CRG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRG1"/>
    <dbReference type="OrthoDB" id="2896625at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="254" mass="27864" checksum="18CEE742055E903F" modified="2022-01-19" version="1">MMTAYRVASYIRSLGQLSPLRGEKGSSLKRMFSSQVAVRPFSTKYTLGELKDKLIAQIFTALRYGPCYQNATKRAYSQASSGADGSNPTVSPYVYPAEDLLKSLEMTANTELPSIPPGQDQEYFWRAYLLANQIILYLAARPPAEAESFHAVLQSAVVELDSPIGRGRAGILKIVQMMVDTISTLPPDSPLRAQHPEVFEAYEKLSFSHQVYTGSVLRADVLCVLAVFHLFIAQLYVLISDSIVVSCLSSIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTZ8</accession>
    <name>A0A8H5CTZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTZ8"/>
    <dbReference type="OrthoDB" id="10255174at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="435" mass="48201" checksum="9625CD9A18970B82" modified="2022-01-19" version="1">MGKPIPRPTPNLPTPKSPEESVLTVTTNSPVRPTPNLPLQQSIPSDTKNTSIRPTPNLPLQQSVPSNTTSTPARATPNLPLQQSVPSDNPVRATPSLPLQQSVPSDVTSSPDPRPIPNLPQQGQAKEDNKVEKVADIPVIPQPRKTLLRSMKDRLKAFFHQKAHPAEAAPKTWSLSDSEDVQLQDLTVEFGDDPYKGRCTVHVRHTRQEDVTNLDVKMEFVGRDKERFTGVFFTIGLINPLTQMPVPVKQYKPPATTENDVFSSVTYTNKVSQGAGVEASMSPKVTGKVGRERGKNFVASETHFTIQTSRNNGKLEWRVRENSAIRVNSGMGLPNQTFSVSVETALPMRVELRLACYYMTRFKLLKKMSVPEDNGFLTGTFEREKKKLRIIQQAVDALTKKQNRVGEEREGKEGKEGKEESVGGEGRGEEGVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CW47</accession>
    <name>A0A8H5CW47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CW47"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5348663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="232" mass="23997" checksum="3E519D49CDCC84EF" modified="2022-01-19" version="1">MVSWNAVNGNGHTFDGAGPSYWDGQGGNGGVTKPAPMMKISISGVYKDVKVLNSPARTYSVSNPAPLTMTNLIIDNSASITRTIVSPSTEVLTSLSPGTPALEDMEFLSDQALRIKTKSDATSASVSDVTYSGNTATGMKRFGVIIDQVMLAQLPLDLHQATIGTPGNGVTLSGVNFVDAQTTISVNSGAQRVAVNCGVGSCTGSWDWSKLKVTGGSAGKITNFSGIKGFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWT5</accession>
    <name>A0A8H5CWT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_015511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000081">
        <property type="protein sequence ID" value="KAF5349397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWT5"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5349397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="709" mass="81140" checksum="37FDF84CC8528DA6" modified="2022-01-19" version="1">MAPKLEMSFTAKWTDTEGLNTLKQIISRRVPQWPNGLRDFQLENIPRVLDGENLLVFTATGDGKSSFYDVPVLVHMELAANPQLYAPFPIRETPVAIVVTPTKGLANSIILEARGFGLSGLSYCHETLVKYSAQDLPGLICKCTEWQIICVDPEHLATKEWARILQNETFLKNLVLFCVEEAHLIRSWSPNFRPQFEFIGATARGFIPEHVSIVALTATCAPGPHTLAISQSLGMFGSSYHLIRRSNERINMQLIVDPLKREKAVPKFAKILDYLRDGRKTVIHVKTIPDAYDIYEFLWRHIPPGINRLRRMRMYHSLCTDDYNRNTFERIDNDPLLQVVIVTVAFMVGINCKRLLDSISYNFPLTIDDFMQMMGRAGRAEDVTCRGIAIVPEKLVQQAKDFMHTYLEIQPRASKTAIKNKSRKKKEDSEEMDMGKASFLAEEICLTGNINDHFSNPPVETSRLDCREADCKVYCALCAKRYSISYTFKASDSESSFPWLPLIILSPLKSTTPCKSKTSLGKAERLKMRNWLEAFRQLVHSEFEPFTPILSHYPIAWFLSDAIIDDVLDNFLKIKVLEDLHVLLERHAWKYIEAKGDMLLRLIIDFQEKIYEWRSEDAEAKTKNRPKKQVSKGSRKKKQIVESDSEPEMEYESGLSGEENQDMEEGLMAIPITIQPIPSNSTRPRKPRKPLQTMNEVAAEYGPIRTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D046</accession>
    <name>A0A8H5D046_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D046"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="262"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="53595" checksum="7641AAFF95A8F08A" modified="2022-01-19" version="1">MSTFQDDGLPGCFSGLFKRRKAISKPSPSYYTPSDTKPSLPSANDMKEHSCFSPTCDYSFSNLSQWWISDQSISPPPYTPHSASASSATEDAWKIIDETTDTLDPQLRKLSLQIHDHPEIMFHETYARDVLSAFMGEHGFEVTTGYLGLPTAWKAEYSYGSGGRVVGINSEMDALSGLGHACGHNLIAVSGCGVAIALKAAMEQKNIPGKIVLLGTPAEESGGGKILLLDRGGYKEMDFCLMCHPGPGPSHSFDTGSTSAMQSFEVEYFGQSAHAGAAPWEGTNALDAAFLAYSSISVLRQQIKPTHRIHGIVSGKDWLPNVIPDYSKMRWIVRAPTWPELKVFADKVQNCFKAAALATSCEVKINSEAPYFDLNQNEALAEAFSCVMKERYGMDTSSLGTTASTDFGNISYGKSLSIPLMTDIRAGLAIPTKPNGGNHTPAFAQAAATPEAHAAAMRVTRGLAQLAFRGLQDDTFYAQMKQSFMKSSRSQLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D0N8</accession>
    <name>A0A8H5D0N8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_013526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000070">
        <property type="protein sequence ID" value="KAF5351426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D0N8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034777128" description="Cytochrome P450" evidence="11">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5351426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56678" checksum="2F50E22F911FB903" modified="2022-01-19" version="1">MNLSNAGILLLVFGATLAFYLKASRSKSGTRALPGPRGLPGIGNLFSIPLRHPWKRLFELKEEYGPIVHFHGFGNSILVLNDYKTMIDLLVKKGNMYCSRPYFHVACNLMDLIKSTAFAPFGTRWRLHRKLARVALNPEALKTYEPRLMEIAAMLLQSLAARPDDFINHARLAAGQVIMSTMYGLDISSPEDPYIVRAEAAMSIISKAVVPGEFLVDLIPSMGFMPSWVPFTRFHKIGRQGRELIAELVEKPYQFVKDQMDAGADVPSFTREALTEAELQTDRAGNNEEFEDAVKWAAASMYAAGQEVISSAIINLIMGLALNPDKGNKAQAEIDKVIGDRLLTPEDRQILPYCDALVKETLRWHPPLPMDIARASIEDDVYNGYFIPRGTIVIPNVWSIAHAPDPDFPPNSFIPERFLSERANAPLDPSLYVFGFGRRICPGRLVAENFVFIMSTTIIRSFDIRPAKNPDGSSVPIDVEYSSGLVSLPEPFRCSISSRMKNTLVDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D244</accession>
    <name>A0A8H5D244_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_009381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D244"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5352095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26359" checksum="4A6CEC43A9C6287F" modified="2022-01-19" version="1">MFSMPSVFKVEAGSHRVAAIALGLSLVGNLFVLLYQTNIIFGVTTPKYTYIDADHPRNLPLAVRPANMVFKSNLGHFGMGKDPKTWAEWSTLRPVEAGYLFLGQTYLPIGLSMWHQYHCLDHIRALIALGDDGSDHTEHCFHYIRASILCGADSTLEPRSRRSFDVEGNEIFPGDGVTHTCRDFQQIYDWTMEQRKGWSQEQVDRFGIFGTAKHGSHEGGTNTEHGMHEGTRSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3L3</accession>
    <name>A0A8H5D3L3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3L3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="694"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5351577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116179" checksum="BB3CE1579EF328D6" modified="2022-01-19" version="1">MKNYDSFKGQPTFTRPPRDQNLPLALLFDYQGANSPEHPLFRYDQDGELKTILWKDGNAAIRRAASLVRERISRDGDSIPVVAVLAHVDSMTYFATVAGIMRAGYVPFPLSSRNSPAAIAELLQKKTARHIFVNSGPMKGLLAAAIRQSGVKINIHDMPTFDELYKSDQAVDLPPLEGITQEDAAVILHSSGSTAFPKPVTLTMRMLMESAMSCYSGEIDVGSQILSGHAVPMFHLMGLIQIASTSYLGVTMAVFPPTIPPVIPTPVSVFNAAVATHCTLFHCVPTFLEELSQDSERVKVLSKFLSVAYGGGPLGTDTGDMLVKAGVKIVPMYGQTESGIISQCFPSGPEPLGWQWMRLSEHLSPAFVPYGNQENLFQLVLKKCSTHTPAVLNTAIDGVPALDTFDLVQQHPQNPNLIQIYGRADDQIVHSTGEKTNPVPIEAILAKDPNVASAIMFGRSKFHAGVIISPSPNIKFDPHGVAKLAEYRTLIWPTVQKANQFAPAHSKIFKEMILVANPNKPFEMTPKGTPRRNAVLKDYAEEIDEAYIAFDESSQVQFNPPKSWNTEDCTSFVRTAFKSVMEQNVKLEDDDDIFQKGCDSLQMTWIKNTVLHALKCNNKVNIREIPQNFVYAYPTARQLGEYMASLAQGNSLKAVDVAGRARQMKLMAEKYCKNFTERDVAHGAEADTSGAVLITGTTGHLGSYLLAKLLHSKDFTKIYALNRSSSTALAARQESSFAERGLDTSLLQSPKLILLEGDLSKEFLGLKNDVHETIREELALIIHNAWHVDFNVSLSSLEPHLLGTRRLVDLALSSRREAIPKVVFVSSIAVFDNWHNNEPGTEGYLDDPAVAVNSGYGESKWCAETILQEASVHTPLKPVIVRVGQLSGGPNGEWNTSEWFPTLVRSSQTLKKIPKLAADLSWVPIDVAAQAIIELSDGKYQYANLVHPRPIPTSVILTSTASLIGAEVVLYRQWMEELSKSADRSAGNPALRLLDFFQAKAASVDKADAGLLGFPSLSSARALECSQSLRDLVHRQLDSKDVEKWIAYWRKIGFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D499</accession>
    <name>A0A8H5D499_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D499"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5352953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="37372" checksum="620B846ED3900C19" modified="2022-01-19" version="1">MRELKFHSEKETLARLFCYHLGNKRRDSEFCKLVFVDKPLDDPNRDCTGYLTTKFHACLVIPIPSLRPRRQSVGTCCAACFPREIPLETLGYLWYSFTAFFRDPQMHYNETTAPEAWNLNNFRIGNTHKCHSRFRTPHAQIFLKGLQIVATIIIGLLAWDSTDRATASKCYAEAIQLAKTRPPFDCLGAGNQKPNEEVARNTKHFNYFVALQVKETKDNLATLIGNDIWQVGLAKAAEEILNTGNFTSPGLRREGVNVLLPVTRIEGDGTMRTVNNVMLASDGCANCGKRDVKLHRCSRCHKVAYCDAQCQRQNWKIHKATLCEEKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D549</accession>
    <name>A0A8H5D549_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">D9758_010623</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D549"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="307"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF5353779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="571" mass="63331" checksum="745B56961DA10966" modified="2022-01-19" version="1">MGGSGRGGSIQGLDKTKALQAQVLELTEKVNALQTSRKGSGPANPDLLCSNPKCKRCGHTIENCFREGGGKQGQNLAWWKGKKDVPVPSANNTTAYTSDDLPTILALSTIVQHTTTIPLPHDPICIIADSGTTHHFFRQKSSFITYLAHADKGGSSHENAEFDIVGRGDVKVEVMYGGVTYHLLFCDVFHAPNVSNNLMLTGTLDRLGWTAALGKGWMVFKQPNGKETFEAVLDGGVYVMNAKLIKPNTALAAQLPADIRYLHRASGHIMPEWIEMAYDLVDRIPKVKGTRKVMGTCEDCRKAHTDKQAYPDSTETITEANFRWYLDIWGPVQVVSVGGHLYALFGTDAGTSRDMVDFLKDRMAATLIEKLEVRRATAETQTGKPLKSIRTDNAPEWRSQAFQVWTSSHGIIHEFTAPYTSPSNGKAERGIGAMLNGTRAMLFDVNLSARWWAQAMATYIYVKNIMPNTRQIVPEERWTGQRQNVSHLVPFGSVGFVHIPAKSGRGKLDPRGFKCQMVGYDGRKVYVVKRWENEELYCTSDVVFEKSDGHWVSALEGENEDVLFLEPTCWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D988</accession>
    <name>A0A8H5D988_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_006385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D988"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5355524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="302" mass="32847" checksum="03C708140ECB4DCF" modified="2022-01-19" version="1">MPSNLRGLNIVHPVQPDLDSQDLLSGQPFPDLSAQLALWTNLPFESEEGPSTVQKQDNFDKGMTDERVNEEIHRQGLKAMAAHDGHINVVTGINIEQPQVQPRAQHQMSGPQQQLDLHSILSTLGIDPFTAAQQLLQSQQPPVAPSLAQLLTLHSASAASSFQQHLPQASAPNLSGSSSSQIETTPPPAKRARTRKASVSTADSPEADTTSANPLSASEDKRRRNTAASARFRLKKKEREMALESKAKELETRVNELEKECEGLRRENGWLKGLVVGVTGAAQSNAQSSALPSLKRSREEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D9Y1</accession>
    <name>A0A8H5D9Y1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_006093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D9Y1"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="13">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="12">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5355351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="247" mass="26358" checksum="03FEFE2026771E68" modified="2022-01-19" version="1">MINRSTVLCSLCFPCVRSSTSVSRSYATAKPAASEVSSILESRIAGTSIGGNVEETGRVLSVGDGIGRVWGLRNVQAEEMVEFSSGVRGMCLNLEADNVGVSIFGNDRLIKEGDTVKRTGQIVDVPVGPGLLGRVVDALGDPIDGKGPIEAAERRRASLKAPGILPRRSVNQPMMTGLKPIDAMVPIGRGQRELIIGDRQTGKTAVAIDTILNQKRWNDGKDENKKLYCVYVAVARSVPPLLSSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9C1</accession>
    <name>A0A8H5F9C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_017984</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000364">
        <property type="protein sequence ID" value="KAF5328302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9C1"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034395918" description="NodB homology domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="13">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5328302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="297" mass="33101" checksum="6F9C7E6BC718F3D2" modified="2022-01-19" version="1">MFSVSSLINLSLAAIAFAHAVEPGAKRQTLAQVITTCKEANTIALTFDDGPYIYGPDLVDLLDQNDIKGTFFYNGDNYRCIYDKDMRSNVQYAYSHGHQVGSHTWHHDDLATLTWDQIHDEMWRVEQALQRILGVNPAFMRPPYGSYNDLVLQASAVRGQKVVIWDFDDGDSTGSPPDESKADYDQLVSKHPNTVIALNHETYDTSVHDVLPYAIQKLKAAGYKFATVAECMGLDPYQSVGNPQENDVSAHSHLIALAFGCSESLRYLRSALLTGKLGLQLKRDRELGLSENSDYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FE71</accession>
    <name>A0A8H5FE71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000284">
        <property type="protein sequence ID" value="KAF5333835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FE71"/>
    <dbReference type="OrthoDB" id="3265672at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="118" mass="13476" checksum="F92BC7DF734727EB" modified="2022-01-19" version="1">MPAPQAQWKRKKKLDKQETKIQQALNDLASGIYKSCPQAAAAYGIPYQTLYKRRKGQTQDRRKAHSSQQNLNPTKESVLVDWAKFLASTGHPVSRRTISPKFHALTGQRPGLWYLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGH0</accession>
    <name>A0A8H5FGH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1554" mass="169622" checksum="DFAE90335AB12A36" modified="2022-01-19" version="1">MDFPSEPFLVPLIFTTISGSRDRLDRSNFIEGNGSITPSSVLASWGPEEGGRMRGSVIGLEDGSIVILPSLQRQEAHVQLNLKTPVHLARSTSPSSPSRMSVSRTSLMTSRSPSPSGHSPSPFSVNMRSRIVSGVTTEQVEAPKNYVDFDEEADKLKDMLKGHAPKEKEREKERNVDRPPSVDAGSSGDKMTPGNTESSAIKRKDAPRSHLSVSGSHAFTTSGHVLLPCRGPRKSVSNVQLFSDLEVIAVLQESGHLCILHSTDGRSLTTTHLNNTNLLPPEGVSPRNSQHDLWIWDTLRAYCAGEYTLLVACASLDPNSSSFTCADSPELGGSEQCRLVVLELRTNHLAGAFSVTLEKLGQWYCDSSSKAVELYWTPERQYAPYSYCNASLAYTSPEALMFCYINTDNHFVEQKLHIVPPGVIPNPAAGHAQAFRDRERDHQSAESLPLNLSHALGPLANPFKQTKRTEQTTGVSDDSSPQPGRVTLGPAFVSTEAISAMPHRNYRFAAIEGLVRGLVWSDQEVVAFMYEKRSFRVLFACQWQNIIDCAWFENDQLVVAFEDKCELYSLRNVVDANNDVVKAASLKELPQGAIVQPKLLLQTFITEPYDSVELTSSRHFMMTLRDSNGRRVLKSFHWNDVSDEGQLLQLNEPKNSTDSSRIIWSSRKSSVSRDQSDSIGTLSAVMPLSVNLVILGYTDGRLRQTTLTKMCQDPGSNWSSFYGKTSEVSLGAPVVILHLVKSEKTNERLMVGGGDDGSVGIWNMDLKLCAYWTIFLTLLTKVIQFDEEDLRTSPLRGCILCVSEDGTIAVVALDSLQFLYIIPGSPTPLHEIWLKEDENHHHHLLLLYTDRRVRLWDVKTKEFWRSMASDKAEELKSQGGWKVKSLDKPTSSPSPLSVIGSHDQGLDSVSTLVLNMEHFISESTTVIKSISTSKNQTANILAARDRLKAILSVLLTPGINPSIDEICEEQLGIVVMGDVSVGFHKLGCTSLYQSAVSEQPWRISGEVSATRALAIIVSLRALGIFEEFSDAVSTVSAFYTTSLGSLIGPSYKPPDLAYLAQKWFDAIGSVELRHAVRTLFDAAVVRLSDEETIALVNEWQQHLPSLQPEADQESRTAALSLFLCGYLAAEKYSLFSTSALTDITKSISLYLHSAYPQHSHHAPVHFHPSYLILAIDLSSRGFHVWQHYMAVEILRRLFVLATSARKELMATTTFPPPAPGISSSPVKPVHSSPSPSKSNPSSLSRATSASLVTTGAVTSTTTVSAVARNAVLAIAGREEARGLFVMTLGMEITGTSSLSGDRPSSTTGGAGDGASASAAAGGDKDSKDSVLEHRKAVLQILAFLIRKRPLVLLPNLPKLLEAVVKSLDPNSTGGKDRDAVLDTVTEILGHVVKTFPSIDFHVSSQRLAVGTSEGTIVMYDLKTAIRLYVLEAHKEPITACSFSPDGRRLVTLSLKESVALVWKVGSSFSSFFNPGAPPRQSSRTIGGIGGWGGTGGTAGKNASDGDEPYKKLGFNVGEEGIMTTAETLKFVSFDWVADRSVKLKIRESILTFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FI17</accession>
    <name>A0A8H5FI17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000215">
        <property type="protein sequence ID" value="KAF5337541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FI17"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11617" checksum="7CFCA0659FCDE79C" modified="2022-01-19" version="1">MSQPKALVIVDQFHYDYWYVVKSPSGIGLIYQRSAFTFFSCSNLDLHALSQSLLLSPSQALAREQPSSFGDCGDTDLFNDKVQARRNGSYFAIGKLTVSFLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJF1</accession>
    <name>A0A8H5FJF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_012096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJF1"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5338802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32685" checksum="C112492EFBCDD13A" modified="2022-01-19" version="1">MSEQKKPLPFAANFAAGAIAGISEILTFYPLGAMSCVKTRMQLSTEKSQGLFGSFKTIIREEGFGRLYRGLVPPLLLEAPKRAVKFAANDFWGKTYLSMSGEAKMNQQLSILTGCSAGATESFVVVPFELVKIRLQDKNSTYAGPMDVVKQIVKKEGVLGLYAGMESTFWRHLWWNGGYFGCIFQVRTMLPKAETQQGVLLNNFISGSVGGFVGTLVNTPFDVVKSRIQSVTKVPGVKPKYNWTYPALVTIFREEGPGALYKGFVPKVLRLAPGGGVLLLVVEFTLGMFRQVLGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMN6</accession>
    <name>A0A8H5FMN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_013368</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMN6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5342805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58653" checksum="EB45FFBFE5B91A55" modified="2022-01-19" version="1">MPFHFYMVSSHFDPWNTLALIVLVTLAVRIFYKPKRNLPPGPKGLPVLGNIFQQPQTLQFLRFAEWREEFGPIFSLNLAGQTMIVLNSHKVAADLLDRRSTIYSDRPRFIMALEILAGNMMMFFCGYGNLWRKLRKGAHEGFNIRASEVYQPLQEKEAAVLVGNMLKDPNSWFDHLNRSTVSTVLTAVYGMESIKSKDDPLVAQVNDCAHRLTRAAQPGSFLVEFFPIMKYLPEALAPWKKEGNEWYRKDTAMFQGFLDDVQSKVNAGQAKATFVAGLLERISSQLSTVEAGWLAGTMVLAGSETTASVLSVFMLAMRLYPNVMKKAQAEIDAVVGRDRLPTFEDRDHLPYIQAIVKEVLRWRPVAPLVPRRVMKDDFYEGHFIPKGSLVVANIWAMNHDPTIFPDHDEFRPERFLDETGAVHAIPADTRNLGHVSFGFGRRICVGLNFANQSLFIDIASLLWAASIEPAYDETGAEIVPSPTEYVDKGVVVHPAPFRCNIVPRSGDADGMLEVAKRKSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMU4</accession>
    <name>A0A8H5FMU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMU4"/>
    <dbReference type="OrthoDB" id="2844577at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="64048" checksum="B5D535DD4280D989" modified="2022-01-19" version="1">MSHFTEYLSGRQIHETIFLSAADAAFLKSRLQDEEERIFDLTTELETILLEISQRKRTVAKLKDILSPIRRVPQEVLGEVFSRYVELRESEYKKSKANPVPYHFPKEAEKRLYRMVPPALLISHVCSHWRRVAQSTPRLWTLLRIPASAPRLANEKLPPKELVVDWLQRSGCLPVHLSIRYAHTGGGDEASYPNILAPICQRLCTVKLHVKYDFMVNLFGNLDDITFPNLEKFLVRVDGPRLPAEGHLPRLGRAFKHAPRLWNLKFFHEFDSLQRGIQSAVDFPFPTSQITILVLHTLSHDPIILREVMCACPLLEICQFWNVPDFPTNALGHRDLPFCELPCLKRLTFQFSGVFGSPQILNDLCLPALEELALIERGVMVIPISPYLTTLYQRSRSKLRFLSLRRCLFGSVEDFFDVLKLVPSLRTLALTDCGLDIPTFCRGLRATPEAKVPVPNLTKLSIAEEQDIDAVMDTDEDPDPPLSTDIDIAEMVLSRWKPYPPEQDVTDAAADGGTVKWPITKLTRGFTLEAYCRALEPEAMSKLEECKQEGMALVVRRGKTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNC3</accession>
    <name>A0A8H5FNC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000158">
        <property type="protein sequence ID" value="KAF5342748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNC3"/>
    <dbReference type="OrthoDB" id="3056556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5342748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="325" mass="37921" checksum="8E88A162768D9B28" modified="2022-01-19" version="1">MRPRCDLQCPVISGLQQFWSTFSVILCKQRRPSNPTDPIFSHMMSKDRNELARDILKTAFGVNDIKDIPELESVSEERLNRFRDDCECFGPNIPLARLDTSARTATAMRDLPWNQMLISRLAHKAIDLANDQPADHSSTKLKQYPFSQWKKDFALRVYKILLQIQKGRQLGLEEGVRLRYNAHKLYTRRKTARRKKFQRRQRLCIRMKQVSEQLNDEDGFEFWNDTLRLITSLTEDGMSDEEDAVEGEQRVKAVQRVESRLPAFDNVLEFVDNLQEDEPMVFHSAGRKRLRRVTAELLENADSVEQPPTHLIEADLSLQSETIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNF4</accession>
    <name>A0A8H5FNF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNF4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="6823" checksum="3BD3A2C54E3A5288" modified="2022-01-19" version="1">MLDSEECFLPCAGIILTPFVAVAVAAAGVSILKVRKVITRPLTSDVYCLLALVSFPSEGDRAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP02</accession>
    <name>A0A8H5FP02_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP02"/>
    <dbReference type="OrthoDB" id="3020010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="492" mass="56556" checksum="7F5C1649D8348279" modified="2022-01-19" version="1">MQSIHISTDDFPTAQDARFNPQKWNVDWERIHSVFVLNQSRLKSIVAQASGARQFGRSVHRPQLRKSRTLPSSIYTDFEKGWLEAKVADRRKHIFTALTNAGSQAETLTQARAYCGDILLVDRLSKDGRTLLDLLRAAIPGDLDPNAPPATPYYFPEPTWDKVRTEYEQSSNFNQLEKYTFKEMLLLRTKLIWAMNSFKGDPLPNLLLAKERGAQTATEKREEQKKFLNEMKAKYGAKEGALRARERLAVMKEKKYACSHCKRPEAEGQKYQRCKPCWEKVQRIVLYCSVDCQKADWKPRHKAICGKFADSIDEAIRLSSLPGKALNETLPPSVSQVGPPVDGYKRSPLLVAHIIDLNHNPDADFIVHFGPGPDDFDEVYVFPPMQKVFLEAREKAMTTGDKETVVKLCHFVVWLCKADKHDEVDEWDLEEIIRHMEKEFEIPDLKKELRELQAQQDADRCRRPPLALSLSSVEWMTYIATYKTDLSTRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRP5</accession>
    <name>A0A8H5FRP5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRP5"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="771" mass="86790" checksum="FB780A6844D76013" modified="2022-01-19" version="1">MFLPKFKPFSPLSTPSPSPPPSPKHHGSRDHIHVHGRGRSSSSLDLLLPLPAAVSPRRSHHRRTRTRTRFFPYALTFRRYSLGSRVLVLFAGVLCLLFYRRLFNNGSEIHDYDHDHRYTSTSTSYPRPWSYLSNASSLPSSPLASTTSPSALNQQELPPLYEKWIRYERSLPQHDWSLSSPPPLFSLGPGSERKKQTKYLFVANHAYGVGWGNVLQEMFLNAYLAFVFDNYTWDKHESDYSEFKGKKIPSRIPVSSMLSGFMIGDPFSQQSHLSQVGDNSDGIPPAISKEYFTKICPNPKIITTGLKRRDLTSGPMVMEDANSANPHNHAHMEDGLTKMNKWIEQINEIDDACLQVGHDGTGMVGGDGDDEEASVFDLWFFFQPSILTLWPALLTSPVITQFGFSELVKEGFEANRGLFYPFHPHNRVYSVAEAQADPVLVRGYVHGPSEPPSQLADPGLSLSSFLPWPISMPKFFRIPDHISISTSLSSVLSPISSFFHKFTTPQAPLKPTSNSSHSPTPNAHNPLNFNPSSLTAPSDADNDTATIPNLLTLHIRRGDFLDFCRDLKTWGVGFQGFNMFEELSFLSDSTYLEGTMDRLDGQDGNDRDMVLDRDDGSAWNWETYRKHCLPSIEEIVDKVARVLKDQEVVKSRTSWTVYIMSNAPKGWLDELKDALTFSSSISSSSPNTNENTKSPNHNQNQNQIQSSMKIKVHTSRDLKLTRDQKYIAQAVDMYIARRSEVFVGNGFSSLSSNIVMLRMADGVKPEKTRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FS04</accession>
    <name>A0A8H5FS04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FS04"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5346979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="532" mass="59930" checksum="563F7836E01F15F4" modified="2022-01-19" version="1">MDQNASTIAELRAEQVDQISDNLSRLSYRRLASLDASADTDSSSSSPLPHQLQWVVESVKELFNKLEPEQLVVVLPRIRKLMDLGRVNQTNVLGLGLQEFDEFGQLLGRLVTAKERRSKIPLVRYLPWISDIAPSKVNGPASPEWLEMFVHSDVPSVCIEDHNACCNICLEDFVEPALAAEFQVDGGDDGTQASPKPLRQLKCGHILHEECLPMFRSHDYNSTFECPACRTKVWTPADPRQFSFRSPKIPRDAARNNVCLDQLQTYTDYWKSLSPWQKMHESLSTWATKLSISILDEALNSTTRGHPVNEYALSIWIHQMYKRYVYSRMTGSPEGLVDCLTIGSMTAQYISALVSKGKHGDASRELRKFWYGWGLQGAPRLLALSAKHGRPDESHWVVHRFSLPDGTLTTYHFHSELHACPDCRPASWWPAIRLAWPDAAICANPSMPTLIHLHQPMELGVDDSVAATGIRDNVLMGLPAEHSVDLERLRDLIGTEVKSLRERYISWASYLSTFFGDLHGRCERVEGDGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSX8</accession>
    <name>A0A8H5FSX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSX8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28639" checksum="9F2C74A47B86F99A" modified="2022-01-19" version="1">MTSPDGAKLASGSWDHTLRLWDVATGTQITEPLQGHTQSVRLWDVVTGTQITEPLQSHTNWVVSVAFSPDGTKLASGSKDHTIRLWDVVTGTQITEPLQSHTNWVVSVAFSPDGTKLASGSKDHTMRLWDVATSTEITEPLQGHTNWVASVVFSPDGSKLASGSGVNTLRLWDVATGTQIVEPLQGHINSVDSVAFSPDDAMVASGSGDHTLRLHFPGQSSGIVWIPPQFHELLWKAENTLIISRQGYNKILFDVCVWRCYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTS0</accession>
    <name>A0A8H5FTS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTS0"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034472619" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5348358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="45071" checksum="F255788EA50EEDC2" modified="2022-01-19" version="1">MDVRPLPFFKHLSLLLTIPTIFAANAHFGLEKRSTIISGNQTWTSQGCFTDISVGRTLAADFYSNNNNMTTESCIAFCEAGNYIFAGVEFGQECYCDSVIQFPGTPAPDPSECSTPCTGNATETCGASGRIEIYTNGRPAPVQVQTIKGSSWAYQGCFTDSPSSRVLQIPMPVPVGVTAETCTAACQTAGFTNAGLEDGHECWCDNILGTTSTHVSDLDCRAVCVADHSQFCGNANRIALYHLFDNNGTSSTGPSSSQCIAQDSANFTLVAHFNTPPPNGIPSVVPLKVLLVEMVPSVTWSILSACPLCCSDWPSFSMKGSVFLPHSLTNPGQLMVSTAPGPGESPNFVASAPAFPGFQAYCIMNSTNSVAPRKLLGFGGKSDAFSLCANNTINGRLDVVFEPVTSHPHYTLDDCSPVTIEVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FU25</accession>
    <name>A0A8H5FU25_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FU25"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36111" checksum="91E551B199727579" modified="2022-01-19" version="1">MILPAVQHIAKHILRHLADHSQRPLFVAVQGPQGSGKSFLTGLVHSYLSDEPHRLRVASLSIDDLYLPHDGLKDLAETHPQNPLWRGRGQPGTHDVALGMELLKSLKSGVKEVEIPRFEKSLFNGEGDRLPLDGSGVVVKPPLDVIIMEGWCNGFYPISREELEKRWNGVWKDVKDSLKMDDGIVGTRENVEEVNDALFSYVDLWSFFDVFVQIKPDSSETSTPYPIVYKWRLEQEHGMKARNGGKGMTDAAVKLFVDRYIPGYVFFGDGISQGYVGGKSEPTGDRSTGGTVPQSEPASPHWLGKSIRLVIDEQREVVEIEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FUL8</accession>
    <name>A0A8H5FUL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000082">
        <property type="protein sequence ID" value="KAF5349317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FUL8"/>
    <dbReference type="OrthoDB" id="3069722at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5349317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="926" mass="101755" checksum="6615B5AE9DEC3257" modified="2022-01-19" version="1">MSATQEHVYSPSDDSEGPVLRDFVNETIAQELEHRTQSPHSPRSELLSTVPSSSAGFLAHGIRDSSGRRGPSRRYRQEREQVYKDTSRSDLLRLLIEHEYENSKMRKTLYMVFTRLEEEQQRAANAESSVENTVQQFKLLNDKRLAAEREAQALEEQLTLYKVQYNLAQTEIASAQEKIRELALQRDDAEEVAEKARGDARKVREAMGVWKAREEGRKQGFEDGWRRAREEFSLAMGKPVPALTYENALDVAYPPSILDVPHTNNDDDESSGHESPPRRRVRPAMLMDSAPSEPSTHAGPSDPITVDVVSPSPKMPQPELFVAPPSQPRSSRPPSRASRASRAPSVPHSTSHSISHPIQQPIFPAPPPRPPSSHASHLTRTPAIQMYPLDIPPADELTFNNQPPPVRTNSWRRRPKPRQQQPQQPPPPPLPHTWKPDIPQRRSPSPRPPDNYIPITNGGQIILPPPHELADYASPQVLSTELPEPGRVSSLDGGARQALPQSQSRESWSGRGRTTDARPIGEGSQPPMQAHNNASSSSWYLNKQQQSTSTLGNDEPQERRSMDSAFSRGSEASTNMSHLDILRDPSEVQKRPGLGKSFRNMFKGKGKERVLSVINENPLSRQGSVRTQDNPVLGSPNRLSHSYERHNSTPSEVKQRFVDSLRYENPEDAGAWRGQPSSSGSHPNSGHFRHVRVPSQLTIPSPLSPLNHNQGHGRSLSTGSIGYPSSQRQSYGGANGSQMGASETHSRRRVSMAPSNDTSVGVGVEVVPPSGPPSLADHSRSHASSERLPTVPNSPENNPAPMWPHDGGGGRSSRNSRIARDPSPARSNISRPYGASPSGGTEQPLRPASVASTRYSRRQSAAQSGSVDPGASPASISQHIPGTHDPGESEGLRRVPSSLSMRSKGVYDHYDPSAYVDPAFYGQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FW92</accession>
    <name>A0A8H5FW92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FW92"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034946392" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="65" mass="6771" checksum="9AF7519E49719EDC" modified="2022-01-19" version="1">MYKFISALFISALVATAAVQAAPQLGNSCTQNSDAALAIFCVATTPALFAANLAHYFALIKSSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXC1</accession>
    <name>A0A8H5FXC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXC1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="171" mass="19102" checksum="F8318EAC127A01D6" modified="2022-01-19" version="1">MDFGTVIPPEKLTEMMHARHNGAMAFRYPENHQFRINGIVSQQLLTNTDQLNDNSEECLIVVKDSNTTDITVGHATGMVSFIRDDGTGEVSRELAVYNYDKKSGVFSAKGDSGSLVVDYKGHMVGMIHAGTLRGGSDRADITYCIPAWWLIDCIKERYQHADFNQLTWIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYH2</accession>
    <name>A0A8H5FYH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_013788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYH2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5353609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56071" checksum="E53355B7EBC34EB6" modified="2022-01-19" version="1">MEPLLYLALIAIPALLVYFFIIPPSNLRHLPRVALLPLLISYLKQESEDKRMQHLILPFAEARGEEVVLVWALGHWMVHILEFKLARKICDNTDCFPKETPSDASLLWRFVGTKSLLMSNGIQWEKQSVLINEAFNAQLPVDVFVALSYRLFKLIGEERTVLWDDLAQRFALDAVGSSVLGHNFEAIETDNPFVKEYNQVMAKIAAPLYLLFPWMEQLVPRKRLICRIDNLAGKFMNLLEHKRDSPGDDMMTYMLKDPGMTLKELRDNMIVLFLGGHVSNISDAIATTLNSHKFQDTTAGSISTLFYFLACHPEIQQRARDEVKRVFGDDQNPTADLVSGVSLPYLTACIREALRINTAISYIFPRKSLQPVRLGKYAIPAETSLIVNVYAIHHHQGAWKSPHDFDPDRFLDPQWSKSGWLPFALGPRQCPARNFAMYEQRTLAAMFLREYEWALPPDSIHLNGIQNSFSPFALTLPHDLHLIFRQIRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZC4</accession>
    <name>A0A8H5FZC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZC4"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5355285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="277" mass="30119" checksum="8D66C986ED77A0B4" modified="2022-01-19" version="1">MPVNAAAENVLGTMGTICWSIQIIPQIWKSYRTKDTTGLSEWMILSWAIAGAFLGAYAVLQDINIPLIVQPQTFSALGTISWAQCLYYGRNFSLLFSVMACLGMMAFIGGFEAALVFAVRPAFEAGKASGKSGLEFFGIFASVIIALALLPQYYEVWYHKEVVGISISFLLIDALGGLFSDLSLAFKPEFDVIAGVTYSLVVVMDSVIIMAALFLNPRARRRRLRLSSEANTPSRTNSINAAAAPDGNDDVEMTPRTPTTTMTTTVLPDRKNDDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZW3</accession>
    <name>A0A8H5FZW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZW3"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25959" checksum="7EDB3A2B6A26B7B4" modified="2022-01-19" version="1">MAPFTFFKFVRDQRTPLAPVVKADLTGKTVVVTGASAGLGFEATKHFATMNPGRLILACRNQQKGEAAISDIQSSTGFSRMELWIIDLNDFTSVKTFADRFDNEGGRLDILVENAGISPMNVDERTKDGWLGVFQTNFIAPALLAYRLLPHMLKTAQDHSTTPRIVVVTSELHYWSTVHKNQAVINSPTPLKALSSQEYSKKASPDDEYMDSKLLNVLFVRDLQKRLLNPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G070</accession>
    <name>A0A8H5G070_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G070"/>
    <dbReference type="OrthoDB" id="411632at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5355469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="403" mass="47110" checksum="0F40B71DB9475E28" modified="2022-01-19" version="1">MFSSTLLKRTAVRLVCLAIPIILILVASHSVLQSSKSFQLYGTDHKTRTTSPYAHSRPGSKGSEGILLVSCLFPLSKAKHSADDYAYWMSNFLGKVKTDIYFYTTPGMASTIARLRGDLPIIINTTFSSPYDIPPLLGLEDHYEEMHRKDRERKIHSPELYAVWNGKAYYLDEALKNSVNEYEYVFWTDAGSFRREHFYEDWPDYDRVEELWEEGSKMSGMRKEDLFFIPTAEAPGTSHRYWEENMGPVDTDFTEGSFFGGRVEAIEWFRKVFYAYHDHYLSLGMFVGKDQTVFNSIMLLYPSRIITVWLTDPHAPAHKGLYRSVDAGMLGDCGNPWFYYQFFLAEVSTRGKMREFWKAEREYTWDWWEQRQTCRLTRLLTMKDLLGRRYGYRYIPPGPTLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G155</accession>
    <name>A0A8H5G155_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="15">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">D9758_009537</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="15"/>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G155"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034003326" description="tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]" evidence="23">
        <location>
            <begin position="34"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="24">
        <location>
            <begin position="484"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF5356414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="882" mass="95773" checksum="E9A3CF323E5EDAC7" modified="2022-01-19" version="1">MRLLQTILSSLMISFAFTLLLLAPSAGPQGVNAIRLPGLAPDLGLNLQAREVLKSPRSEESPEHFWDQVNNLGDKVVNYTNALLKETAKLYPAVQSSISSLQHQISSTLSSPGIQTLRSELEQSVLFLNTNSTNFTAGFVDLTKWSNDLSTEFELIMDQFQIEFPLPSEAPNHEERVKLINTLMDRLEDGFVKVANMTHYGVDQEKTREIFESIRSGMVGALVTVGDIAEQHPILLEATLFAVTILVFPEECILRPLFSPFGFGPLGPVKGSTAAWAQSRFWGGTVTKGSWFARLQQAGMTGRGWGSIPKAVLGDRCPIFDVRSSGVRRKANEASSWGGWGLVISLYIRIRLRLSPPIVTHLQGTTFSLLKAPGTMILALLGFGSSGIIKGSIAAWAQSFFWGAAVAKGSWFALLQSAGMAGAGLSGLLKISLGIISGAVCIDVQTSSTSEVLEFCRIKMWADDTHRNYRIANFDVDSGEEGNPATDRPLIIQFCANDPEKLLASAKMLEKHCDAVDINLGCPQDIAKKGRYGAFLMDDWDLIYNLINILHTNLSVPVTAKFRVFPTVEKTVEYAKMLERAGAQILTCHGRLREQRGQFAGLADWDKIKAVKEAVSVPVFANGNILYQSDIEACLRATGADGVMSAEGQLYNAALFAGLPSTSSPSASSSSSSPATSTTSPPPLYNTQHPFNADLALEYLSIVQSLKTRTSISAVKGHLFKIMRPALSRETDLREQLGKVQIGRNADLSSGALQPYIEVCEEMKRRMMRDAKAAEGKTLEELITIDKATGLQILPHWLAQPYFRPPPPPLPAKEKVLKFNSTIPAKRPVSEMSSGEGIVDEGDEEGGGRGLDASIIGLEKGKIAKPKLEANLEGVGVPLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3J4</accession>
    <name>A0A8H5G3J4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3J4"/>
    <dbReference type="OrthoDB" id="2623028at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5357705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="257" mass="29493" checksum="E962E4A792D55B90" modified="2022-01-19" version="1">MAQDASPVEEDFSKDWFTERLDLIQQKIPKPSDSSDSESDSSSQLPRRFQWVVESLKKSLNEPEQFSLKLAETSMLLDHTADLSDKPDYVQEFHQFFPDFRRRWQDGRVRDVVQERRSKMPIVRYLPCIPDFPPSEVNGPAPPDWLAMFVHSEIPSVCIEDYNACCNICLEDLEEPPLAMPDDGDDVDPMADDSGGRTSPKLLRQLPCRHVLHENCLPMFQSENYDEVFECPVCRTQVWAKLDEPSVSCPVCNNVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5G4</accession>
    <name>A0A8H5G5G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5G4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034408997" description="GST N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="585"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5358752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="820" mass="90451" checksum="E23E95AD04F20D05" modified="2022-01-19" version="1">MKFSSLLTTFVLLVPSVTFCIGSGVAATSLYTDPNDLPTKEYDFIVVGAGTAGNVIAARLSEDPTKSVLVIEAGVDDTNVLPIHVPFLAFNNYGSGVDWNYTTVPQKELNNRTVFVPRGFTLGGSSSINVMIWTRGSRDLWDHYSKVTGDSGWGWDALEKYWNRISTYVPPTSNPSPLAIPPPNDPTLSNGNGPVLVTLSNFPGELDGKVINASKLLQQENGADSRFKYTADMNTGDSLGFGYNQQITGHGERYSSATAYLHPALNSHRPNLDVLIQTRATRLLQSWNDTSDIPHFNQVEVAQSVDGPRFKFSARNEIILSSGAIGTPQLLLLSGVGPKEELEGLGIDVVADRPAVGKNLREHPLLLTIYEVNSTKTFDDAIRIPALQQQLLEQWENNRTGLFANSVNSVLGFLRLPDDQLEGTQDSASGPNAPHLELLYADGFLPVLGTQPATGNYITVANVVVAPKSVGSLTLKSTDGDTFTQPLIDYNIYGDSFDVQAMLQAVNDSETFFSTAPWTEDNLIISLAGRNSTSIGATEEEKIAFLKDNTVTIFHPVGTASMGSKDEDVTDARLRVRGLKGVRIVDASVFVGPWSPNTWKTRYSLNFKGLPFKVIWVEYPDIEPTLKAAGIAPFTTRKDGSPYYSLPAIYDPKTGTGLTESFAIAEYLDKTYPDTPQLIPPGTRALQKAFVATFWDSKVPSEDQFVIPKTTWILNPSSEEYFRRTRLVWYKMTMEEMYPEGAKKESEWRKLETELGQMAKVLKDGIFVMGDQISFADLALAGNVNWFRILYGKDSTEWQDMASWHDGRWGKLVTALERYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAF3</accession>
    <name>A0A8H5GAF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAF3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="38884" checksum="FF5417A9FD001EB3" modified="2022-01-19" version="1">MTVDRRSMLLGRQYEEVPSPTAVPIKARTPDPDKVLTQVVDGISRVISEFGPLATAIEPTSKSGEESASSTSSNPPLQTISGSGSITFPSPTTSLHPLVTEDARSSSSSPKLKIILPSVAGSLVLLVIIFMIMSRCYRRTTKRPRSMINDHITRRGDPAEHPTSGPNIIHPYDLKTNDQFLQSRISEPFPGESTQASCSNDLDSTIFGRRGIFERLLWRNGTNHSELPRPYELKRDLLPLANQTAALTSETQPHRASIASSPSISRPRPRSSSESLIARSDTQTESTTQQIQLREEADELRSQASRYERDFVRDEEMRRLRDRIQMLEMQVNSDRATGLTDDLPPSYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD65</accession>
    <name>A0A8H5GD65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD65"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="259" mass="27973" checksum="03E1DE29CD724C9C" modified="2022-01-19" version="1">MNTSESDSDSTHTALAPPPTVPQDSSSTPQFSPPSVSSASLPGSPTMSEAFDARLAHLEQASQSQSKQLTEILATLQGRNPPPPPPPQPPSQHPTRPPSSASSSTPPSHHSSGASHAKASPPGIFDGQHANSQVWWTSAIIYASTVHFKDDIAKIMWVLSYFQTGHAATYCQSLINYGHLYGSSCFDTWREFEAEFIKEFMPEDEHTQASLTLEGVSYFQGTASVEKYVDNFHALITMAGLNIEPVLYSMNPTAPTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDU8</accession>
    <name>A0A8H5GDU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDU8"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="46702" checksum="63FAE45E1E606642" modified="2022-01-19" version="1">MFPTQLESQPKGGVDLSVLFKPMQLGPLTLRNKFFMAALTRDRNVPGNVPTDLAVEYYRQRAKGGAALIVSEGALITQSGSPWPYAPGIWSEEHVRAWKKVADAVHEEGSYIYAQIIHIGRVAHIDAPEQIASGEPVYAPSPIAVRPGGTSRFRFLPGQPGPSMPVEINNPRKFIGEFRHAAINAKKAGLDGIEVHAGGGWLIHQFLDNTVNKRSDEWGGSVENRARFGLEVLKAVTSVFGPGRVGIKLTPTGGYNDVGMPVEDTLETFTYFIKEADKLGLAYMVFQRYEVSFDETIDGQISHGHLHLYHFTNVSDSWDVGKLRGTSHDVIQTWGPLIKNAKVFGNFNYTVEEAAENIASGKLDGVLFGRSFIANPDFPKRIQHGVPLNNLDWMTVYRSAASDGGVASKEELSKGYTDYPFAVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGV0</accession>
    <name>A0A8H5GGV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_005524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGV0"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="158"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="395"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="526"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5364707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="839" mass="92676" checksum="7F2C75CE63EC0850" modified="2022-01-19" version="1">MVFSTIKRIYNAFSPSEVPTTQDNKPLKFGILGAANIAPNALIIPAKTHPEVLVYAVAARDIKRADAFAKKHGVQKVYGGTNGYQELLDDPDIDVIYNPLPNGLHYEWTMKALAAGKHVLLEKPAANTAEETRQMFDLAEKKNLVLMEAFHYRFHPAVQRVKAILDSGELGKIKSITHQFTFPAGVMGLKKDDIRFNWSLGGGSFMDMGTYNLNCLRYLGGNPTQILSANAVPSHDPKVDRGMTVTLALPNDIIGTMTCDFGIPWKWNLIPSMPVLNATVECEGGSVKLSNFVMPTLYHSITVNKKKATGTDTVTRTEAVYKFSDAKMEGKGEEWWMTYRYMLDAFVDRLKGREPQTWITKEDSIVNAEWIDKVYEKYHGPQHNQASLQCDSKPLKFGILGAAAIAPAALIIPAKTHPEVVVYAVAARDIKRAEAFAKKHGVPKFYGGSNGYQELLDDSEIDVVYNPLPVGLHYEWTMKALAAGKHVLLEKPATITSEEMRQMFELAEKKNLVLMEAFHSRFHPAIQRVKAILDSGELGKIKSICNTLTVPAGSFKKDDIRFDWSLGGGSFLDMGCYTLSCLRYLGAGNPTQVLSATAIPSYDPQVDRGMTATLALPNDIIGTITSDMGTPWNWNIIPSSPQVLSTVECEGGSVSLLNYVSPTLYHTITVSKKNGTGTVTRAEKVYTFSDGKMEGKGEEWWLTYRYMLEAFVDGLKGRTPQTWVTKEDSIANMEWIEKVYEKSSDKKKLRSVVDQLGDGSKVVDLIWDNLFKPVHGLTTSALGGYKLGSMKGDDNMYRVGIFVSNKKTLKPPPIVVAEWNAEPTGAQVVAGLNQAIDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH05</accession>
    <name>A0A8H5GH05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_005536</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH05"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1118"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1176"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="800"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="867"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="939"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5364664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1221" mass="140179" checksum="4CFA2BFF6D718189" modified="2022-01-19" version="1">MTRRQINISTVRSNFKERFSSLSQGPYSTFIGVRLPGRSQRRNKVDPNTMVAPTSSLDYSEIPVIDWQLSETDKPTFLRQLRDAMINIGFLYLGNHSVPKEVIEEVKRVAPTYFDLPQNVRDSMDMSNSMHFHGYLKWDSSTVSGGKDSVREQFNFGGDRVCRWKEGEPEYLKLQGSAMWPTEEQLPGYKEVMLKYYKHVEDLSYKFTQLVSESLGLKPDALDAFFDEDHDNLQPRCKVLRYPGSTDSTPGTGIAAHVDGSFLTYLLQVTDHRTLQVKNLSGEWISVPPKEGTFVINLGKTLENVTQRVLPATPHRVISPVGPPRFSIAFFSSVGLNVRLADAAVLKFPQEVLDMKAARDRKLGEEREFKFSEKDYQLSGEVVLARKLRSHADVAEKFYPKLFPQFYPNGRPERAKTGSKPSAIAVDFGGDISPTRTSSDFEEINYPSHRDTGLPTYYMEDKARRRTKATGNDIDGEEKVPLVAQNEYYDDEGKDVYNKRPPKGRVGSGRMWQAPPPRPASLNMEHIPPIIYTLLSCWTRFHKIGAADIVVWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLAGLLAGYDGSFDFKSGAQYPENVPYVAMRVMLATFGVGMVPLGWYTAVELGLSQWACHLVALMVLFDVGWLCISRFILLDSMLLFFTFLTVFCLTKFHNQQHDPFGFDWWMWLSFTGLSIGWVTSVKMVGLFVTALVGLYTVEDLWEKFGDLKMPVRDQVRHWGARIACLIVLPILVFMASFKIHFMVLNHSGPGDAQMSSLFQAHLVGNDFNKNPLEIAYGSRLTLKSMGWGGGLLHSHVQTYPVGSTQQQVTCYHYKDENNEWTIMPRWDEPEYNPNDPEIRFLHHGDTVRLSHKPTTRNLHSHPIPAPVTKLNWEVAGYGNSTIGDMQDHWVVEVVDDVVRGDIKRHKDEKDQRIHSLTTRLRFKHQQLGCYLRAANAILPQWGFKQIEVSCQAADATSKSDEHTYWNVESHWNERLPLGDQKYYRSPFLRDFWHLNVAMMTSNNALIPDPDKEDILASKPWEWPLLHVGLRMCGWGDNQLKYYLLGTPVIWWGGTLSLILALATLGVYILRWQRKYVDMNDREWDHFVYVTKIAFFGWALHYLPFLIMGRVTYLHHYLPILYFSVLMLGHMLDHFIFSSKRWTQKTKAISFGVCATLIFGTFWWFRGVAFGIDGNVNDHWGLEWRKSWNLYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIL2</accession>
    <name>A0A8H5GIL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIL2"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034739433" evidence="3">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="85"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="388"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5365425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="54051" checksum="B35B5D38258C6885" modified="2022-01-19" version="1">MLLITWLLSFILSSVIAQAGFDWNSTEPTTNLSWVDCYSGYQCSRFRVPLNYSDPENGQSAVIAVIKLPAQGSASEYGGSIFSNPGGPGVSGVNYVLESGRRVQSIVGSQFDVISFDPRGVNFSTPRISVFHSEEEQSDWALHEPADSNSTQEALPEAWARYQAFGEFALSRDTGILNFVSTANVARDMLGMAEALGLEKLHFYGTSYGTYLGAVFASMFPDRVGNFVLDGCLDMDGALNNDLASLIVDTDKSMQTFYDSCHSAGPDSCPFYSSSPSEIEAALNDIYETVRLQPVPVSSGDTFGVLTYDRLRGAILAALEYPPLFPTLAEGLAELQAGNGTIIYHSGTATVAGLSWDALVAIWCSDTNPSDADAEQLRQYMSKINSTFAGMESLPMMNRCAGWKYHPDERFKGPFGGNTSSPLLLIGNTADPITPLSQAKKTSSVFPGSIVLTQDSPGHTTTGTNSTCTHQHIAAYFANGTLPEEGTVCSLDEPLFPDVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJA7</accession>
    <name>A0A8H5GJA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJA7"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="111"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="41072" checksum="448C1F81BF22E5E3" modified="2022-01-19" version="1">MQTAVSTKYLRIPENTSMTPLFKKNRKLILSYAPDWLLTIALGAVFFSLDKVEGYRREFSLADTSLRHTYAVHERVPNVALYLICFAAPFLLMPVINLLTIRSWWDFHNSSLGLVLGLALAGSITQFTKITVGRPRPDLIDRCQPLNGSVDPTYGLSTDAVCTRTDLLNDGFRSFPSGHSSMSFAGLGFLAFYLAGKVHLFDERGYTGKAWLSLTPFAGAALVAISRTMDYRHHWQDVLVGSLLGTVMSYFAYRQYYPELSSLVSHLPYSPRLRYHGDNEGVLPLHHHRSPSGSEEITGQNGNGRPGQNLVRRYTDEPIDYELEQTARRPDPGPLEDIWSEGQRNDGIRDPSQHTPGVVETDFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJE1</accession>
    <name>A0A8H5GJE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJE1"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034300064" evidence="2">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="23901" checksum="7907F3D6B18E88E7" modified="2022-01-19" version="1">MRWATIFWRHLLKLLIDKLTLPSLTNLAIRNFYEGVDEWDTDVERMFKRNWPYRTFADFFQRSSCLLLVLHIDYISLPENDLCSLLKLHPFLVELRIREICRKDYDFAPYPLEDDTVFQFRDLITPLLLTTLHAFDHGLASSSPLVPKLENLHFAADGDLFDDVLFWKMVVSRWVPSDTGSHRENTSVSHQGKPQRHFHANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJJ9</accession>
    <name>A0A8H5GJJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJJ9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="116" mass="12521" checksum="742AD62E6D51E7F3" modified="2022-01-19" version="1">MRGATAPDVTKEPKSLIIKVQVPVPFELTGRTPATSTPPAPSNNSNGALAVYTKKRDFVCYIKRAEQDQGGLPYDQIADVVKTKGVGGVKAYFAAELRSEDELVVKISEVLAEQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKM3</accession>
    <name>A0A8H5GKM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKM3"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="43480" checksum="C7E2C485B8E53B74" modified="2022-01-19" version="1">MTSPSLLSQSKLFQPIQIGNMHLKHRVVLAPLTRLRVDENYVSLDVIVKEYYAQRSSVPGTLLISEGMGVFPKGGAYKNIPGIWKKEQIEKWREITDTVHSKGSFIFAQIWSGGRIAVPDILKSVDPSYVVVGPSTLQCKNLPWPVHPLTVEEIKEYVQAWGKGAENAVGGAGFDGVELHFANGYLLDQFLQDVSNNRTDEYGGSVENRARFPLEVVEEVVKRVGQEKVGIRLSPWSVFQDMRMQDPKPTFSYFAKKLKNLYPNLAYLSVIEPRIAGDNEVSVDHTEESNDFLREIWAPKPLMSAGGYTRGSAMKTADERGDLIAFGRQFISNPDLPFRLLNDIPLTKYDRSLFYCPGDNSGKGYIDYPFSVEYLNQKKLEMTSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMY5</accession>
    <name>A0A8H5GMY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMY5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="94" mass="10926" checksum="7FF501A79E105C26" modified="2022-01-19" version="1">MPRLGLDRVLKPIDDNHDIMAACRYHHSFSLNRHPTLKPQPREEYSSRLIAYLYKPSQVSVIEMGSSENFNNSHFKLSKIYPSDSSFHYSYPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN86</accession>
    <name>A0A8H5GN86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WDR59/RTC1-like RING zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN86"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="WDR59/RTC1-like RING zinc finger" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="811"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="695"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5368038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1197" mass="129151" checksum="4686CB09D1CF8D24" modified="2022-01-19" version="1">MTSGQLTIQSSFETFSDSRTHGYQGQTRNVRLQRAAPSGGGAISKGQDGLRCAVTGYESLRILRIYDPDTQPPKSQSSSIHKHASGPGGFRINASKNLWEGSGQNSTSTDVAWCHAQFSNKIVTSARSGELIMWDLNKSGSSRFERKVKDHLRSIHKVSASSIVPHYCITGSSDGDLRVWDLRSFNKSIMRIHHPTGVRGVVFSPVMWQPLQAAVGLDNGNIYRWDLKMGQRGQLDRIPVAHSASVTSLDWCSSSSETSSATPSAIENTGNGQGWIVSGGLDRCVKVWDLTALTSNAPSQHIPHKPAYVLHPSFPILGLGVMQIWVHSIASAPPTQAQSMLNRRGSGLGLEISGEREPRARSSGNITPTITKNTSAPSTSGAGDPVEIWDVRRSWIAKWTVPGSAVDGGCTDVVFGDSHAIWAQHSTGMFSQIDLRDTIRPIDAIPRATVAWEASGSLTFVADPQREWEVPYDDLLPEVKQEAKSKGRTVKQLGDPVYSGFSRGIGVHYGEDALFKLEMFTNLARRYIIEGEDRAQTCAVNAETAFRAGHHQAAQVWLLIAASVTNIIPETPPIPVAQPKKPPRPKPIPMEHSYSAPAAMSSIPFTFPQVVSKTSPGRTSTLGSDKVSIPNQNPNQNGNSNHVSQRSMSATSSGFRRVTPGSSAHSSPHQGSSALPPSPLTSKHPSYLGRRESVDSGLSVASSSRLSGGAASSSRRLSSLRRPSVSTTHSPSSLSLKHVGEGALDDSDSDSSSGSGVSGVGGVGKSGGPFSDDEEEASNLRPLISPALVPTRIANPSPLSRVIRHHRWVQLEDGMDERDDDGGDTPSPRSTDSESISDVDVGGNAATPHAIRTIMTRRRSSTTAIKRKSKSRSQSSFGIPKANRSSSASGVVPLGIGGDDREQSVSTESKTGVIKEPRSATNHHREKSVAVSELILNDGDSTSVPGSSEALVITWTQRDPEIVVAEEKRFRQITWDALRGSLEDFAESGDVQMCAMMAMLIPQELGLKPKRVLAFIESYIDTLTRLKLYPCAAYIRKHSKVDAIYGTTLVFRWKPSSTPPVDVVEEHLFLHMLLRMLEGPIPIVQPAGKTTMTCSICRLPVRGLLFQCSICSHGGHQECYNYYYAQHPMVDLPSQYSSDKAKETSDQANANENVASEDETATLNASSHVNAPHVLPPKLAGRPCAAGCGHYCWLVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNX8</accession>
    <name>A0A8H5GNX8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNX8"/>
    <dbReference type="OrthoDB" id="3250108at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="384" mass="42385" checksum="D9BF4EB95C323E96" modified="2022-01-19" version="1">MVLAALPHIQISPAPPDESLPEPYTPFSWANTTLDDHDGYRPKHLTPPPTNVKFNALPSPLRPAPTPGAGKGLERERFEALLQATRERNATGSAKKSGDLRKEIALKVHKNKQVERRALFLSKVLAPPSPTATLQPKTPPDSPAIFHYSLPSPGLVSPLALFESLNDTSTTGPLTYAREPWVEQVDFRTRRQSGLKAADKPVLPVVTDKKATKTMPSLEEISARLGQQGHTRTPSNETVPRFSMNIDRPSADRPRLALGVGRLQMPQPQQQQRPVATFLPPKSPLSPLSPKIEVRTMVVPRSSSLSPTELSESNLNALASRERKARNMLSTIRRRMLPSDDGLNGHDLEIPDQRKWKRRSAPAEFSPRPRSGFEHPVLSIPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ73</accession>
    <name>A0A8H5GQ73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ73"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="794" mass="85807" checksum="872E7D5E93BA0D9E" modified="2022-01-19" version="1">MDSHYQSPQDPDNFGEPQPHPYLHEPLLYISNIPPYVSDENIAVAFVTCGPFRPKVPRDGTSSLLSGTIEFRFLEKAEKALATLQARPIPGLTPPVHLMLSPYPPTNPPTPLPPPSATPRLVKHLPPGFSDSQLYDLFRPFGALSSVRTQTPFGPDTGMVEFWNEDDARRGEEAMHCADVEGSNIAVQIYQPRRTASGTVPEFNANAPAFVPSGSVYPYPAQQYSPPRPHYSPRSVVSPIPHFVHGPGQQVQLAPPSGPGSNSHSGLIDPCNLFCKNLDPEIDSNGLFTHFRQFGQIVSARVMRNENGESRGFGFVSYQTPDQAAAALHAMNGVTLGSKQVVVRLHEPKQLRQEKLAQRFGGHNGHPRNSSGATSPTASEGGESYQGWGSPRHHSQPLASPTAHFDRSERGRRGSGSYYNAALQGTLNISMRYDDLASLSPVVRKEVLTGELSRRIKDMNTVAASDIDPIVDALVNVSLSEVVQVIEDPEKFAEQVRNLQTSLRATSNDNSDKSPSRSASASQDSRLLDPNQLAATASAPEHPGTPISGHASLSTPPRTSSPSGSVPPTSERDRFLAAVSKLESSNQEQLTDLLMSLPKRERAMCLFNMEVLRAKLADAKVVLETADDEDDKVPEVPKTPQNKKTLPRADMSPQTPELSSRGPSEAASPAPSTPATSSSNYTIASLAKLPAAEVVRLATGPNAASLPFPKADPLVVKATDEFIDSLLDKAPQEQKQKLGDKLFKVIKSFGIKGAPKVTIKLLDEEDLRALAHLMNSYPSVLKDKAQAVATVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQT4</accession>
    <name>A0A8H5GQT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQT4"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5369317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="350" mass="37899" checksum="5CE7D8FC326AE574" modified="2022-01-19" version="1">MPFIHLPTLPLLSTFGTSRRHSFSRLRSFHLSPDGVKALNLEAGHIQQTPSTPSRSSPAEPGPHVPPKPVDHTKTTPPPPPRAINGSVPIPKIFFFVLAILSSVLFVVTILATFGGAQAGPPVFKSILDEVAETNPGIVLLGENVDIDIDEPSVGIRWSILACGTDYVLSGSAGVHGSKTCGLPAFPLLIFVDGDTEPTASYNPAGIPFDRQKGERRNIQNLVQFDSDHVLDVHNDYLYPFDSYRLSSTLRATSLSSNESIPIKKLATIEITSAFVVTTVDVESYSTGAPWQNQSSEDTQSPSRDIDMYIQRPAESRAIALVLFAIGWFLTHICVGYVIMARGSQRLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS89</accession>
    <name>A0A8H5GS89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS89"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="259" mass="28347" checksum="76CC770A30EEA647" modified="2022-01-19" version="1">MFSGLHGMSRSDADLAQEALTQEGTYRFPSFSASDAVTLGLSLRKRFRASHRHAKGKGLVLSIQSIAGHTLFSCTVGDLGHFSGYADVGLDSWSCLEAMIEVVKRTGHSSFYVEKGMNALGKTPKQMPGLQGDVRVQGGVLAFPIWLENAPICPVAVIACYSGSSQDDHNLVVNSVRDYLNKLLRDGRAGASVTMPIPSIASVPPPRPESRSVSARHDYQNHRHHGQRPTSWQEWNLPEVTTAASEYTRPETPYDEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSP6</accession>
    <name>A0A8H5GSP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSP6"/>
    <dbReference type="OrthoDB" id="3123112at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="3">
        <location>
            <begin position="342"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="453" mass="49865" checksum="181A4EAFCBE9B596" modified="2022-01-19" version="1">MYALPGTPAKLHGLLASTQLSAEPTGATSTMSTPEHKPFATGLLVSLADVPLYFYIYKPRPDTWFPILTSSLLGPGTTATTSGQYATPSSVSDSSVSASPPPPPTPLLCVDWLHGLDLTDQKHVSFDINSYLENREELYNNCQQQPCPHTHQSIPQVRYYFWEGEHSIILPSNPALLHFHFLRLAFSHLLFFGPESSTSTVPSPDITHTPLPLSAPPSAIPTARPSPTLIPNPSPLPVSPAPLSPIASPITDIDMSSTALENLLQALVNNQNQLQQAITNLVNRPTHESSDKTAKPAPFKGEPAKLDSFLSLFILWAGEQKRLKLDSGKLDPQKCIAEALLMMEGPAAEWAAEYARHISRVRADEAGAVFPWEGNWDSFTHTLKVRFGVANEQQLAKNKLELLKQGDKTVAEFSQIFKMWAEKTGFSDQDLQYKFRKRLHKDLKYGARTEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT62</accession>
    <name>A0A8H5GT62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_001969</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT62"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033990551" description="glucan endo-1,3-beta-D-glucosidase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5370758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="345" mass="38382" checksum="6B19213E49C40D80" modified="2022-01-19" version="1">MKNLLVFLSACTFLLLSGCSSRASRLPNSGNNVDSHLRSNCFPALGFQPPLSTPPDSALDTWWCDPADEHAFMGFSYEVTACQSPAQLIREFLDIRDHFHGRYVRLLQLSDDIVDAAWISGLGVHALIWFGFDGDDIWIGRRDTLLAALHANPRAKFITRVLQFGSEPLFDNVLPVNQLTAQVEMAKANLSSLGIPVTVSELAFGYQERAGSQALLDALDSINIHMLPFFSQQASIANDSWPIVLNDLDWFIDHGNGKKMYFDENGWPSVTSEGVQPNSPLAVADIQNEHDYYVLLDQHCEDLKAVVGGGIGWFAHIYSDDQEPGYGIYNEWGSLKFPFHPRTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTA6</accession>
    <name>A0A8H5GTA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTA6"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="135"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="395" mass="43458" checksum="0140D455D2E7A90B" modified="2022-01-19" version="1">MILRSQPFKTVYLICELVTTCLIRLPLWTITALSSSRRPRSSWSLKRTLLVRITQRFIFVTGKQKLPNHHAITPALDAEGVWIEPVPELITGELEIWAEVANVAPLRIPGYWLNKKGEKIEPGASPMPAEKVVYALHGGAYCRLSAHPSDPTAAIARGLLKHVDTVHRVFSVEYRLSSGKPYAVANPFPTALIDALAGYNYLVNVVGFSPSDIIIEGDSAGGNLALALTRYLVEYQNSKSAKLPAPPAALILLSPWADIGESHHNTGSSFFENQKSDYLGVRKQKGYGYASQAFLGPHGAGAAEVNRYISPASVNPSLRISFEGFPKTFIVSGSAEMLYDCIVTLKDRMAKDMGEDNVRYWEAKDGIHDFIAIGLYEPERTQALQAIAEWVSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUR1</accession>
    <name>A0A8H5GUR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUR1"/>
    <dbReference type="OrthoDB" id="3006363at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="523" mass="54400" checksum="45AB0401FF38B1CA" modified="2022-01-19" version="1">MTRRTQFSRASSRLQFRDNSNGHQSSSSNNSNSDSKHDGTGSNSNSPSSGNGGNTNSNSPNSGNGSGGNTNSNFPSSTSSSGSNPGFCPSCVNDNDPRIIYSGAWSLTSNEGGGFDTTTHETTQSGSTVTFSFNGTGIIVFGSVPQSDNTVFPPTVNYTVDTADPVTTQQPFAVNTIRNQPLFVSAQLSPDQEHTIVINVINASAPYELDKFYVFPAHNFTQNSVNGNHSPTSSTSSSDSEATTSALSGSQNGSTGSIVSMTTLGITAAVLGTLVVILLFTSLFLLFRLRRLFKLQRNLQNFAINPLTANRYHHTCAPSFSSSSKAGSLSGSGSDDYGWSRSMSPVLSEAPRTMTGTIFTSTESIMRNYPSTNYGTSAGERSTTYSYGAGSLRPTSSNSHSRHSRGPVTNTVPSLPPASSPIPARSSPVVPVEGDGDCLNSVNSDSGLGPPGIGSTGSLRPASSNSHSQHSQGPSLPPAPSRIPGRSSLVVPVEGGDRRDSLNTNSGSGPPGIEPVTPHLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVL5</accession>
    <name>A0A8H5GVL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVL5"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="717" mass="80471" checksum="D7388AA8957BF26B" modified="2022-01-19" version="1">MTWTLDRHASSSLSRSVKAYPPNPLRPLSFDKANQGKPYNSNKDSSFPIFRLPIELFQYITPYITSQDLETLSLIDRDCHQLARSVQFTNVVMSYSDASLGLLDMLLGEMTPAFASVDSKLSKTVDMDTSTAIDSASAYALGPCIRHVTIDLGPPVIDDSRLARFPNIVLFGAGSSALGLTAEDVYLNALALVLTHALPNLQSISWESRTRLSSRMMEAIMDSPAREVNLTRAVVGSQVLDAFRPHLPSRQDGRMEEEGRKWDLETLKIDVEWVDDRYEDGHGGGTRRGSRDADEDEVTECDVVQEMLSSVAPTLRSFSWKGRDGRNTSGHGYQFRFTGSQALNFPSLRVLSLHNLFMTDSSILEMLLSPRTNICSLTLDCSDYVTARFLETRGYVSSLESFHYKSHPNSTEEGFQDQIVSFLIENPQISSFTSSPRLSSTFIETQLLPVLSSYLIPSRVLTTLHLTFLFDTIPPSSLEAISALQSLQHLWLTAGHQRGWCHDWEIDHSLLLDVLGPLQHLRTLAFTRDSYRVRGGGHRLLDASGSGVSMYYVNKVLPSALDFYTFLKDDEVLLWKGVEDDITRTMASTRSSIYEQAVMADHARMIQRRLMNAAWERWHRGQMVLVVKEYAMRFLGLEWCFVGQLPFRVGWEVPETLYEERKGDSSAALDWGLEKNLGGSGTNAQDAGVTRITIESAFRCDDASLLKGRWERCCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVW2</accession>
    <name>A0A8H5GVW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVW2"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="97" mass="11092" checksum="C481001783985C90" modified="2022-01-19" version="1">MRTIIGPGHTVHENRIYSLKITCGPNYPDSAPTIRFLSKVNIPFVNQANGEVDLSKLPVLYNWNRNYTMETILVEIRKEMASFNNRKLPQPPEGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX15</accession>
    <name>A0A8H5GX15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001678</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX15"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5372856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="327" mass="34456" checksum="C93B450E8392EA38" modified="2022-01-19" version="1">MTSPASTPIPQGVGSAATPSVAPTRSVQRDGTPSSSLGTFGVKSGLAQMLKGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRAQGGVARMSDPAMIKEIVEAVTIPVMAKVRIGHFVEAQILQAIGVDYIDESEVLTPADEEHHINKHNFKVPFVCGARNLGEALRRISEGAAFIRTKGEAGTGNVVEAVRHERAVQSEIRKASAMSEDELYAFAKEIQAPLHLLKETARLKRLPVVNFAAGGLATPADAAMMMQLGCDGVFVGSGIFKSGDAAKRARAIVQAVTHYTNPKILAEVSENLGEAMVGLTIDDQLKGGHLASRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYV8</accession>
    <name>A0A8H5GYV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYV8"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="483" mass="53513" checksum="869EA481CF2753FD" modified="2022-01-19" version="1">MERDCGDRSSAEMGSGGCSGGEDHNNSIERGGELDDISPVVSTVGNKPNSTIGDVSELSSVPSESLFFSDTELRPDPQTGVWTPWNPGDYNWGEYRRQSETVLGPAFDPSLDHNLKSEGLDPPFSSRCFNCGNPEHVVSSCPFRLDRELVSLSRDMYTFFRDYYSEDRIGGDFNNRFYAVEEWKAQRLRWLEEFVPGEIRGEDLRDALGMNGGDDEDTPAVGIKRKRETEPKDQGEAQDDWLRNMGVWGYPAGWATRSDEPNPNDVVRKKILSEYAGRDEAEEFFMFGEQGAVETVLLESSHSQDHTNTSSVMSTSDNGEHSSTGKKIIRWVLYPPNHFSSEMLPVYNGVPLPPVDGMPQFKPPSKKTKISESSFNDELWASIISSNNAPLPSQPPPPLPALPPPPFPDQPPPPPPEQPPPLPSPPSEPPPSLPPLPAPDSSVRVPSNKLQSLFLSERRSELSNPSMDPSNDDECDMDMSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ78</accession>
    <name>A0A8H5GZ78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_000624</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ78"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
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    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="501"/>
            <end position="519"/>
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            <begin position="854"/>
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    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="189"/>
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            <begin position="217"/>
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        <source>
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    <sequence length="1089" mass="114105" checksum="C7BB39EBD9FD5412" modified="2022-01-19" version="1">MACRAFHPSPRLSHVSSLLRRLPLAFQGFHSSARTHQEKGTIDGIPYSSLTVGVPLETFPNERRVAVTPQNAALLRKKGFADVLVEKNAGVHAQFTDDMYIAAGAKLVSREELFKASDITLKVRPPILGQEVDLLKEGTTLISFLYPIQNKDTVDALALRKVNALAMDMIPRISRAQVFDALSSMANISGYKAVLEASNHFGRFLSGQVTAAGFVSLGKSPRGKFWLLEQVRVDHAYCHSRLLSFGITGVAGLSAIGTARRLGAIVRGFDTRSEAREQVQSLGAEFLEVSVKEEGGGGGGYAKIMSKEFIDAEMALFMEQAKDVDIIITTALIPGKPAPKLITNEMVAAMKQGSVIVDLAAEAGGNCEATKPGEIVIKNGVSVIGYADLPSRLPTQSSTLYSNNVTKFLLSLGKDGRFFLDLEDEVTRGALVTHKGSILPPVPRTLPPPVAPPPISAKEEAATKALTPFQKASREVATITAGMGGLVALGKSTGTAFMDNFFTFGLAGLVGYRVVWNVAPALHSPLMSVTNAISGMVGIGGLFVMGGGYFPGTIPQALGALSVLLASVNVAGGFIITKRMLDMFKRPTDPPEYSYLYGIPAVVFTGGFLAAVSTGMAGLVQAGYLASSILCIGSLSGLGSQATARQGNALGILGVSSGILASLAAVGFPPEVLVQFAGVAAIGGGLGTIIGRRITATELPQMVAMLHSVVGLAAVLTSVGSVMQDLSHVTTLHLVTAYLGVVIGGITFTGSIVAFLKLAGRMSSKPLALPAKHLVNSTIFGANVVAMSGFVSMAPAVPAVAAGYLGVSTLLSFIQGFTTTAAIGGADMPVVICVLNSYSGFALVAEGFMLDNPLLVTVGSLIGVSGSILSYIMCVAMNRSLTNVLFGGISSGAVQETTKIEGTITQTNIDDTVDALSNADNVILVVGYGMAVAKAQYAISEICSILRSRGVNVRFAIHPVAGRMPGQCNVLLAEASVPYDIVLEMDEINDDFKETDVTLVIGANDTVNPIALEAGSPIAGMPVLHAWKSKQVIVMKRGMASGYVKRIAENFRGSDVPNPMFYMPGTKMLFGDAKDSCDAIKRGLESRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ86</accession>
    <name>A0A8H5GZ86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ86"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
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    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
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        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
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        <property type="entry name" value="PYR_CT"/>
    </dbReference>
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        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="795" mass="87795" checksum="67AB371DD7EB6659" modified="2022-01-19" version="1">MPMLPDPSKKYKPYTPINLKDRQWPSKTFSKAPIWLSTDLRDGNQALANPMTIEQKTTFFRQLVECGVKQIEVAYPAASDTDFQFVRNLVEHKEIPDDVWIQVLTPAREDLIKRTIDSVAGTKHAILHMYNATSPTFRNVVFRNSKEETVTLAAKHTKIARELTEQCTAKYGTIFKYEYSPETFTQTEPDFALEVCEAVKAAWGKAGTGEDRIIFNLPSTVEIGPPNHYADQIEYFCRNISEREKIIVSLHPHNDRGTGIASAELGVLAGGDRIEGCLFGNGERTGNVDLVNLALNLYSQGIPPGLDFSDIPSVIDVVTQCNDLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEAQKIRHAEAASKGEPQYWDMPYLPVDPLDLGLNYEAVIRVNSQSGKGGIAYLIKQHLHLDLPRKLQVVFYQVVQEVSDREAREMAVEDITNAFRRSYHVGSGFKGRLSLHNFKISAEPEEDSPDSGDESIRRRRFDGTVSVDGVLRVIRGDGNGPLSALLDALRTHLNIDLALREYTEHTIGEDESASAASYVELVPADNRKSSTSWWGVGIDSDIARSGLRAVLSAANNFIGDRELPELKLTVGYNSKTDQTYVASVIVNSLGLELPRKLQASFFEVVQRAARESNGEISMDAVTKLFQTTYGYNTEVKEAKLALRSSKSFKLEHLDEGRRVLTGEILLLGEQKTVTGEGNGPLSSMLAALHTQIEGKLTIRDYAEHSIGEGSDVVAASYVDLIYEVAGKKKMSSWGVATDTDITASGVKAILSSANGLDLVLKKMVNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H046</accession>
    <name>A0A8H5H046_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H046"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5374313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63336" checksum="AAE22E9CD66AF8B9" modified="2022-01-19" version="1">MESISRTRTSILKKLEVPHEKDAVFELTPWINRDIVPLPPSRRTWGSWSFVGFWLVTGINISGWVAASSLLALGLNVWQSMLTVIIGNIIVGFAVALNGLPGGEWHIGFPVINRYVWGVYGSFFPLIMRIMLSFVWYGTQTWFGGQSVKVVIAAIWPSFLTMKNTLPTSASMETNDFVATMIFWLVSLPLLAIPPEYYKVPFRYATLSITVTAFAMFIWALAKEGGGGPLLSDPTTFMGLDSIPKGSDLAWKMVLGITTQIGSICAGILNQSDYSRFARKPGDQIMSQIICVPIMSILTALVGVICTSCAAGFYPDEELLWQPYDLLIAIQTHGGNGARAATFFAGCAFVISQWGINISGNGVSGGIDLSGLFPKYINIRRGAFLTACVGLAINPWKLVNTANTFITVLSSFAVFLGPATGLMVTDYVVIRRRKLRLSHLYNPSRDSIYWYTSGINLRAVIAWINGVWPLMPGFIAAVQDETTSEGWMHTYDLAWLFGFFVSGATYVILCKIWPIKGLGEIDEEDVFGTFEEISSVGHGHGVGASASEQSDDGSKDVDKVVSDEAVPSFEYKSWDAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1T1</accession>
    <name>A0A8H5H1T1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_000077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="431"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1452"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1907"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5374850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1994" mass="227023" checksum="07396F65E816E61F" modified="2022-01-19" version="1">MMRVPDISILSIEDPDSLPYDHLSSSTNLDDHYMQKLKTYAKSLPYSIEPYSKMMEMLDFILRRIIQCVEAQDYDVGLMQWDSMLTYWNMLKYPIPKDRRVAIAKIYFHISITPGMPTQVIATCADGFKALTSSKKKITIDDLRLPWKPIYHILSEDLFLNRRQFEYTQISWVMGYIADNARKFFHPAAINEMLSTFVPLINGQLDTILSSQYYLLTFLPLTHPQPYLPMLFRMWEAINSYIYDERMLDFLAKISEMHVSPKISDPRRIAELPDDARSEDEDRPAWSDDAMKDNGAWPGIYKDVGIFSEDQWHLLMCKCLASMQIPLADAGSLTTGPSADSQAGFEIGRLPKPTWRIVSLSRIIVYSMVPDGMPSPASNAPTPLFTPLPSGMNTPSIQTSTLVDYLSAPLGRSAQLKHRTYLGGSKALDSLARLIASVEGFFHPTNSGGWTADLSAFLKFLVYHFNKRWHEEQQLDCKTPKNRRLTPLMRRELVKSLRTVVLLAMFSESDTVVSNIQSCLKSMSVMEPGLVLSPLLERAVPSLEALIETQRTTACIKALSSIAPAIVSRQNYYPGAKYLIQILELLIPGIDLNDPSKTLCTAAFLSEISQYIKFGDLTGAPTNEMLDYAPRQPSTPGPTLPMFDLNGFGGSVQDEEPRLSNEEEDALLKDTTASFADWIANFIRRVIQLLENLPEEGPNGSAGGASEVQVVDAVAGACNQICVHLSPSLYDLVLNMVYDYASTNVRPNGLRAIHQLVECVANANPEKTLARFFPFCSNIIRHELENGASSERTTSSSTLIPSDATLYWNLAILRGTVYNDGKAVLKYKQEFLSLLKYLHEKTFTKRGFSWTGKLLSSMLLTLTHTYPLENRFVNPDEWNSEEFRWNHHRHWGKLYSPDEIKISWHVPDEGEINFTLQIFKELVEPTLATLNDLLKPGVLRDAIWRNDFCRHLTLVRNAFAGIPTLVKLYPPPDWVSAAAKTSDILNEIPEMIAMLEDLNAGFCLTDPADPRYQYICSLRQRYGEFLYNASVSLRQQGEENTVDAVHILLRSIRTYMMEYGDSRDSYFVNEDQYLSAKNVARHYAKQRVWPRAVYIRRARFYHSARLRWNSLDRIRGPLEDKIIDEVASWSMWHYPLVRISSQSLLESLCSVYDGVRRRTLPLLYKALQPGDDDCMKGALWSLNMPSFGKYAAAEPTLSTELFQVLLRCQHNEKPSIQDAVQVVSDTCLGVFVEPSYLFYDVPTPALNEAVTEFKASLAFGPEDSALTNNCRKFVVQRVHLQEEAIERTIKAVLEIGSSSKIHWRYAILAVRLLRTLIRKDKPISPEMLSFFLKSVHDSHPSIRYYAQRAVMKTGRNIKLRTFCATPVDLFEGRNNNPLKTRVAVHDASHAVAQKLEQDYKNPIDSKKDIEEILFLDKAPGWILGGSLTFHKPPTWSKSPEWDQSSQNALAKARKIVQSSSFWKEVCKYLAEETNETSMTQDAVCVVKSLFQLLEDDPFDSVKSIVEGLIKAKEADKQRAAAEIIAGIIGGSKNWPLQKQEKFWNWFKPYIKTIFGQNLKSDTVGVWTSFLEYTFYNKDPRRVPILFDHILSQFNSLDFNAELSFDVVKILSPFRSSYEELGWKFSPWIDETVERCWLEIHSDHDDVRAYIAEIFAFADKIKWKPRSSVPTVEVFVKECRVLPTDFDLMGVRGWYHMAKIEELVEKFKEWRAERQPGPTAFQSKYDRVGICVCRWLFQSVHDTNALCCFDYIIPLLPELFQVHRRSVPDVTVNDNDELANRAHNLLVRMCGITLTPALIGPILDAILSAQSVSSWKVRLKALPLVQIFYFRQLPLISDAKIVQILEALCRSLDDEALEVSQMAATTLSGIIRLSPRRSVLTLKNRFVRLVKNTAIPDRKDPTYNKCIRQRHAAILGITALIQSFPYTVEKWMPELLTSVLAEYVSDPIPISTAVKNCAASFKKTHTDTWHEDQKRFDDNQLGILSTLLTGSSYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1Z3</accession>
    <name>A0A8H5H1Z3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1Z3"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="23991" checksum="2DBB7208C635E890" modified="2022-01-19" version="1">MVRPMYHMIESTSRHFDTSVLRMSFLPPPLLRSAQSCLRPSYRPCAHRALSYSLIVHSQKQSPAESAKSAPSEDVEEGEKEQEKEKEKEKEEEGSVDESSKITTYSEFLQKIAEPFKTASTPRNWLGQDTPFPMNESFKPPPPLSDAQREHMYKLYMLDPTANSVRALSERFHLSLKRVDAILRLKGMEHAWKKVRNVFFLAYTSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LH94</accession>
    <name>A0A8H5LH94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LH94"/>
    <dbReference type="OrthoDB" id="3092735at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034300124" evidence="1">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5357410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="26273" checksum="1EEF25E229BE1B5E" modified="2022-01-19" version="1">MTKNLLTLVSLTLAGLAATGSATARPSRRQADSDFFFTEYDIARPDSSNGFETCSDDDCENGKWRGLEDDEGGADICGSFSASEVGYRIAGDDSSNVRYKCNDTVQPLIVHYTENNFEMGVFWIHTISQTWDNTPSTRKRDFTPLTFQNRVISAFNSECRPNLPLAITVTDASGVTQTVNGTDDISTPVPDALPASVRIDIDGGDSFADMVIPGPEKVLIQFGGDNSEANCFDGLQLAIADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIT3</accession>
    <name>A0A8H5LIT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIT3"/>
    <dbReference type="OrthoDB" id="2737573at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5358911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="210" mass="23954" checksum="7BC63AB534536554" modified="2022-01-19" version="1">MDSQFKASYTYRIIISLSGRQPNGCSEEPEDLMTSSLRPHSYNAKRALQRNSDADKEAVITFELGQLRLQACPLERYPLKQTITPGSSTLICPQSLEAKAFPAQKIPFREGQHLFSLTYYHYSKAFSPSEELPSKNYVSTDGIAPRRYEYLGPQPCIAGFLMDPSDGVTQILWWDSFLHMAWSNNETWAVDAQFDETVQSWLPIIQKDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPX4</accession>
    <name>A0A8H5LPX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPX4"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="56556" checksum="17CD96247BB3048E" modified="2022-01-19" version="1">MTERRSASADLKLRCANRPHVFHPASNQDACYIPENGDDPWVPCKTQPCLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTNQPSEPNPVPETPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDPFNGERSEAKRWLAQFNNYLRMNKGRYPTEESQVSLFLSFFTGEKGGDWATQRLTERDADEEDEELTDTPDQQRWITLKEIRDRFKKDFRPLASEDVARTKIKFARMKGMDISGYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWKNFDQYQERAVELHLEWLKERERQGRWKTTSTSKNSPGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPKTSSQNTSRTFPSRTIRTTETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQC9</accession>
    <name>A0A8H5LQC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQC9"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="635"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5365677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="77512" checksum="BB27EED850DE2D66" modified="2022-01-19" version="1">MAYNREWDRGKADSASYPNNYDDDYYSQGKRRKFNTGGYQVNDSYDDYAYDTSYQQGRPGQSQDYSQDRSRPGNLPKKRMQASEPSPHVIFLGLDPDFTEADLQAFLNSKGCSVETVTIIRERSTGSGPFGFGFAQFTSSEHARAFVDPLFPFIVVPPPASHGALAAQAFYKAVDAGAPHNGRRVKIDYSQSASPHEKGRFNNRGEKNEGTRDIGNSQAPVLLFRGLDPLSGPQAIHQAMKFSAGPGKEGAKGMKRIILIKDKVTMASFGFAFVEFIDIQPIPCHPRFIQTVFRISDRPVAASFANPESFKPIPEIMLRDEACLTSSLALGGVEGTWVRYWDDTSTVAVLEFQVAQPAQQQTTSGAEKEKKEKKKKDAAPRHSTPAAPSALPVSDKPVTLNFKQPNKQSTSAATIKPLVLGFASDDVSPGEGTTDEINDGSKASTSKKVAPLIASKKTVNNINKWNQVQEELSGASAVIPSTAQTPLNVSNTEPQIQRVQQDEDEFEFADINSLSCLLCARQFKSMDQLKRHNKESELHKARSHHSPWKNYKDANLREIARQKLQARHSGGVGNKGDQPKYRDRASERRILFNQPDAPTIETENGFEIGKKRQAEGPPPPARSATPPALNPGEDENNVGNKLLKMMGWKQGTGLGTSGEGRTEPIKTAIYAEGVGLGASKGKEIGSFTAASSGYLAMAQDSARERYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQZ6</accession>
    <name>A0A8H5LQZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Endoplasmic reticulum Ca-transporting P-type ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_005764</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQZ6"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1206"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="16">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1239"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5366234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141006" checksum="64384AB0E05F0AE2" modified="2022-01-19" version="1">MGRVTVNVDSPEITRASLHISIPWYHYVYTLPFLSLYPVLAFAYFVKYDQWLVSEEWTFLACTSLLMCHALSFLSTRWNTGIRTWVETRKAWSPQEADCIRIVPDVHKGKGEIVPLIKKVPSDVSTYTFNYQRDTYTVSSVSSDNVVFQKLPYPSSSKPPLNTFLKPKGSKLGLSSKQVEELQELYGKNEFNIPIPSFTELFSEHAVAPFFVFQIFCVALWCLDEYIWYSLFTLFMLVVFECTVVWQRVRTLTEFRTMSVTPYQISVYRDGKWKKISSDTLLPGDIVSVTRQHHEHHRKADNKAKANGQESKEAKEQQKEKDKAGHSDETTIPADILLLHGQCIVNEAMLSGESTPLVKEGADLLIEEQQHGVSLDVDGQHKGVVVFSGTKILQANGSTAVSDGIAEPPLKTPDGGCLGVVLRTGFGTAQGQLVRTMIFSTERVSANNLEAFLFLGFLLIFAIAASWYVWVKGIERDLKKSKLLLDCILIITSVVPPELPMELSLAVNTSLVALSKMAIFCTEPFRIPSAGRVDVCCFDKTGTITAENLVLEGVAGVNPQNPKALVNIREVSRDTTLCLAAAHALVRLDDGAVVGDPMEKTTLENMDWAVGKGDVIQPMSNQTSTHRATITIRRRFQFSSALKRMCTISTVAGQGTLVAMKGAPETIKGMLASVPTGYDEIYKGYTREGSRVLALAMKEMPPMGGDLINKTPRDNFESNLKFVGFLVFHCPLKPDAIAALKMLSDSSHRCIMITGDNPLTAVHVAKTVEIVDRDVLILDLKENPANERDLLWRTVDESKMIPVDPSKPLDKSLFEKYDICITGAAMKQYENQPHWNDLVQNTWVYARVSPSQKEYILTTLKTLGYITLMAGDGTNDVGALKQAHIGIALLDGTPEDLQKIAEKQKIDRIKGVYESQLKISARFNQAPPPVPPAIAHLFPDAVAAQQKAVANQMVARQRNPMEKFDLAGITDKLAEMEGEDEVPKIKLGDASCAAPFTSKLSHVSAVTHIIRQGRCTLVATIQMYKILALNCLITAYSLSVQYLDGIKFGDYQVTITGMMMSVCFLCISRAKPVEKLSRERPLGNIFNLYVFLSILLQFALHIATLVFITNLSHTYEPPGEIDLEASFEPSLLNTAIYLLGLSQQVSTFAINYQGRPFREGIRENPTLYYGLVGASAVAFSGATDFMPELNRWLQIVEMEDAFKMKLTASMAIDFVGCFLIEVVCKRLFADLEPKEMVTRGRERREKRRALEEKERKVEEKEKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRI9</accession>
    <name>A0A8H5LRI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRI9"/>
    <dbReference type="OrthoDB" id="3256495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="707" mass="76992" checksum="286B8D17A8DF52EC" modified="2022-01-19" version="1">MDYHSRNACNPQDPHVSSDIDSFSDSDWLDISRESDNESLSSRDSEHIEAASSSLSRRSSFSTGSSRDGEVEAWEGFVEDSADEATPHTRALAPEHRLDIGLISEPDANGNTAEEEKLVRDGLDQSVIGTLSASRSSSYPSTVQNSLRDLRLSFPDPLTSSRDELNRSYDTVLPTEADISISSEETESSVPDAMSDSLSTQDPSLFPTPEVLAQDVQSSWPSETIEHLSSDFEVVLYGRSSHVKWTFVRDLIRKAGLGDGHFSSSVVESVLDREYGAIQLIDNIPVTDRTYGASPVPRSGASPSRPSLAVIFLPSLPPLLDEHTRYLPVITPCSDDSQSSDNIVEEAKAAWSTFSIPASRVLYLQGRSTCSLFAAKDVDKLDPVLARRSLQQLHTPMRSWTGLFEQFNTAHAVTIFALFLLVGFSLNTTLGVQSSKPSTVIALMSPSRVTLGPSIPLNSSAILLRTTSSLSTVPVPLKNSLAIFSRGPTPLSTSPSSFAAAAPSTSKDIQTVSAESMLVIKAMKDLIIRPTTEVENVVTKATPPPVPATTPKSEEESSSSLSLRLVDSLSVIVETTVKALIEVASSEYNELLVVIDEFVRAIDRQRRLIVEQSKSTVQIIREHVGYRHNRAKGRAREIKERTTWAGRQVILYASGGAEVARKRAHTLKDKVTFSTAWSSYTKAHGEWSHRLHNGRPGGGTLGAKLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT06</accession>
    <name>A0A8H5LT06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_002165</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT06"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5368408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="262" mass="28658" checksum="8A0291ECAF595E0D" modified="2022-01-19" version="1">MDSSEPPPFLSAFLSRYHTPSNLRPHVTLTFAQSVDAKIAGQNGKQLILSGKESMVMTHWMRTMHDAIMIGIGTAFNDDPQLNTRHLPPRPPNPAQNGHDKPYHLPRPVILDTHLRFSPTSKLLKNYQQGSGRRPWVFCSSDAPDVKRKQDALEQAGARIIQISGVEDGHLSLPAVLKSLHDMGIRSLMVEGGARVIRSFFSASTSSRLVDSIIVTVAPTFVGDDGVGYSYDSALEGHNSGFKHAFTQVIGRDSVVGLVPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTR1</accession>
    <name>A0A8H5LTR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTR1"/>
    <dbReference type="OrthoDB" id="3026661at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48344" checksum="150FDAB93A3CE702" modified="2022-01-19" version="1">MTPTFLTTRDRVKDFAASASSANAAMSLLPSTHSSLLSLFRTPTRCPRVLCRHKSSRAVVIKNFPSTFTMDRLLTLKGAGRPTELVLRHPENNEVEIRYLHESGAEAVIASASRGELVMDGQKLTADFVRTRALGVQVVAAIGLLKASRTLVFKELPEQFASKENLLAEMSRFGEVQGVWVGDGRKVNVTFSDIMTAVEKTAYPTGLDKLSPRFSLDPFSIHPERVRAGESRESRTVILNGRPVPRITRVLQYLTTLPFWQSVEPLLSLTTFHGSMFLQFSDRERAELFYKSYNPLGVRKKWAPVGKDYLSGPLVAARMGATRTLLLTYFTHPAITLERVEQDFSQFGELGAAFLNITKCVTHHSAKGTARYGPRQALIEYTHIESACRAIDWIYHNNCSFGIYGGSEITFGFTPDVGKQPSSPLLPIRLWAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVD5</accession>
    <name>A0A8H5LVD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Allantoicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVD5"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="193"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="567" mass="61610" checksum="BC3A13232309F5C5" modified="2022-01-19" version="1">MAQAVPLDRFSEIFSATTELSSVAIGGRIVSVSDEFFAEAFHLLLVEPAPSLKGQFGPNGALYSGWESRRHNPTHDWCIIKLGTSGTISGFDIDTSHFNGNEAPHVSVDAIYDPSSEDPTADDPRWTEILPKVSLGPNSRHLLTIPSAPAATYVKLNMYPDGGIARFRVYGHVSPVLPASVSEIFDLAHVFAGGRVEFTSDQHFGVGSNLILPGRGKHMGDGWETKRSRQSGHKDWAIIKLTVPGYLQYVEIDTAHFKGNFPESCELHALYSENEIDWTAGRGEDKEWQLVLPPTKVGPHRQHYFQLENVQGNKYTHVKVTIHPDGGIKRVRVYGRRADIGEASSSNQETLAATPSDDTSMISPSSRPSKSLMKVLPVLPLTPEAFAPFGQVVQAYGDHTAAPKGTKITPANAGTANKFHKLALLSSSYPPDFGATTGLSVYRCQPLKEIGADGITELTTLERHSFTNQAFVPMGSGPGEGLEDPAQRYLVVVAHNGKDDRPDLSTLRAFVASTAQSIVYNTGIWHQPMTVLDKALDFTCVETQIGNGGKEDCEIVKVDAGMGLRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW57</accession>
    <name>A0A8H5LW57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW57"/>
    <dbReference type="OrthoDB" id="3014077at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="394"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5371619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="892" mass="102379" checksum="AF32EC7AE09D08BC" modified="2022-01-19" version="1">MLYWNTLFAMALGPQLKFIQVTRADTIPLADDKETYVYSVAVTNGKKTYDTPWANECRWEVDFPIEPSDVAHAVFKLYRTRKNLPIWRRKLGSASFETQMTAGTEEVGEMKGEYSDLSFYVYTEALLILPLKEMKTDMKARKFVTDSLTLVIKAVGRETAPNVNSGPFEILCVPPNVTHEWNPLDTPENLLENAETLGGVLQLIEPFKEVFDNIAEFHPIAKAAWLVVSGAYQVLKNQHDRDEELVDLYNLMMKTYEIATENDLYKRVGDKKLCVVIDTMVKQSKECSIFISNYGSRRYLSLDILTWFNKIDRILNGPEASARIQDHRVSFSDLQKAFTSGQIDLTTRGVLEIKSIVLSQDSKSKLAELVPQARPPPAIAWCLDGTRQGSLLRITNWVTHGEESVLWVSGVAGCGKSSLMGSMIDYIRDQLGARSRLAAFIRFDRNQYNQCQHVVRELAYQLALYDRRLSEAIADAFQGHTIISPQLRTQLQKLVIGPLDRCRKEMEKDGPMVIVFDGLDECSDDTYSQDFLQFFSDNVFKSCPHIRVIIASRPEPRIRDCFRNLDSEEVLSHIQPFYLDISSEETVKDIRFFIEKELSSIREKGFQEMCIQKDAARGLTRRASGLFIWAVVILKFLRGYACSRLEVVLRTTEPVSALSALTTLYQTALDSIAGPDGDEDIRGDLRILLGFVKFTLYRINHRYEGIDWTILLQSLLESYTGTNWSSKLPVLRDKLSSLLVYDESEYCFQLVHKSLDDFLTNRDRCGNDWFLDHHDFQKILASLCLRFLVSYLGNACMRNSVSSEKIATQYASRCWRIYYIRAWKTGPRNNNFDMEEEVSHLLQRYLLRWVYDIVTRSSFIARRSEVLSHTDDLIYLSERLYKASSQKCLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ58</accession>
    <name>A0A8H5LZ58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase jelly roll domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ58"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-galactosidase jelly roll" evidence="3">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="168" mass="18705" checksum="C2372949E1D4B941" modified="2022-01-19" version="1">MKSPRSVRGFQLNSGAFVPSFPDEARVLNEGRFFGERKGWHLPGFDTSSWDTVSDLSLNASGVGFFVTTFDLNVPQGQDVMMSFNFIESGEQGYRALLFVNGWMMESVSQIWDLKSSSCVFLTIKGRIAVWSMTDTPVLRLNSQLTVDGVFDGTIQKNNPAWSADGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B591</accession>
    <name>A0A8H5B591_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000492">
        <property type="protein sequence ID" value="KAF5315982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B591"/>
    <dbReference type="OrthoDB" id="3029001at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5315982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="11333" checksum="689835942290B7D3" modified="2022-01-19" version="1">MTHGFFISMGGFVTRQDHHPITSPSQLTKEILREIRAAKVQDIEDKSKGDAVSKGLALLQTSWFLFQILTRRIQHLPITALEIATVGFAILNLLVYGLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BSW6</accession>
    <name>A0A8H5BSW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000380">
        <property type="protein sequence ID" value="KAF5327953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BSW6"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5327953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="347" mass="38841" checksum="F5AAEB94DC2CE16C" modified="2022-01-19" version="1">MVATPTAGEIRLASCIGIPIAILVTWFRLFLRLKRKTFWWDDFFAVISMTGITFLWTGILIFTSPGLSAATSEHRSRHIKVVGYYFVDNGFYATIWPARVSILFTIIRLSIAGRFRQLLKIFVGLFLMTWAILDAQVWWTCESEPGWKDKHIAQCMLGKKVAIAQLITDCLADLILVVAPMYLLSTLRSKRSLKIRLATVFSSTFFTTVFSLVHAYAILHDLGYLEFMFAMVISLVVVNLTVITAWFFKLKDGDDSEPSGPSAHMNTFLKGRSSGHRSRKYGGVTTIGLSSLNPAHINIDVTMESAVPFPSTADRIKECGSPPEGFESDSGMWISPVSDSWYHKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C337</accession>
    <name>A0A8H5C337_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_017107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000282">
        <property type="protein sequence ID" value="KAF5333864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1574"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1574"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5333864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1720" mass="186577" checksum="95AE1970E2E72722" modified="2022-01-19" version="1">MIITAQAIIRVLAVQLHAENQLLQKLRTLALVELHTLSFWSSTLLIVPGYIVIASAHNIQTVAGGIILYAIGLQLLTQIIIADITTLKWRGLVSSLISLPFIINAFIGSNVYTSVMKHAGWRWGYGMFAILIPVSLSPLIVTLLWAERRAKRLGLVPPRKHDPNASRISSAWRIAQEIDLFGLILIGTSVALILLPLTLAAKAKGGWSNPSMIAMIVVGCCLLPFVGLWNVKLAKFPVIPYRFMKNRSIAIASAIGFFDFSVALTVFGIMAGVIMRFTHRYKWLLTVGLAIRLIGVGMMLHSRGANASDAEVVWTQILQGFGGGIAASCIQVAAQASVPHVDVAMATAVVLLLTEIGGSIGSAAAGAVWTNNMPEKLAHYLPDVSEEDRAALFASITTVTQYERGSTIREGVINAYSDVMHTMLIIATVVSVVPFLLSFYMPNWYLGDSQNAVDGEGLEGNGGQNAPGVTGEERSDMKIYQDPTYHMIAEAHCPRESPTRRIFGIHKTFCSPNPTKISRTYDLSGFLFGPPIRNETVPTKKKPESTRTRWIDVAKRPAQSSALALLDGATWCRRQQVRTLTSTNKYWKAVKDLSPLSSPSSTWRGPVHPSRYFLPRIYTHRLFEMLYTFPVDYAYTPGVTRRSPPPEAESLRRPLGYSSNPNIISPRPLTSAMQKRPIFNDSNESELQTAVPRSEDHGNPTGPTPDPHYEFPARNNANPTADSSIPFPSPPLPGDLQPIAVQNPPLGTGASAQDLSNHDLTSSQPMSDDFDFGVPFQYRKRDQLHLDPIRRQRIISNFVRYMQRATPNVDLEAPVNPLHSARAASNEHSYNDFDRSLTPYPEMQSEDVTSYGYGLDEELEDEEEEKEEQADEIEAKPGVEEITDSGEECQYFLPFSLDDLDVAVEESIDAPRYSAATLAGLTSPPGLSRSRPLAQQCTSTLGNPHYHQVFSYSYGSVATTNYSYGQPHGYTYRPGPTAYSYEQPPHANHGSSGQPDYPQLEPSLIYETDPTGYSAQPGYACDSSGYSYVEHQPDYSQQSQAGSVEQPQEYGDRHALEGYPDRSFESEKANTLQLWRFEVLDALLWPPPRVRRNEQQNFREQGREKAHVIAPAIGKHPQMHRLSNTSSRSLRRAASKAAAHPPLTRGAHKEIKFSNEGRASILKGVDVLANAVSVTLGPKGRNVIIEQSFGGPKITKDGVTVAKSITLKDKFENLGARLVQDVAQKTNEIAGDGTTTATVLARAIYSEGVKNVAAGCNPMDLRRGAQAAVDRVVEYLSSQAKPITTTAEIAQVATISANGDTHVGNLIAQAMERVGKEGVITVKEGKTTHDEIEVTEGMRFDRGFISPYFITDVKGQKVEFEKPYILLSEKKISALQDILPSLETSVQARRPLIIIAEDIDGEALAACILNKLRGQIQVCAIKAPGFGDNRKSILGDLAILTGGTVFTDELDIKLDKATPDLLGTTGSITVTKDDTIFLNGSGSKEAIQARCEQLRALITDPTTSEYDRTRLQERLAKLSGGVAVIKVGGASEVEVGEKKDRYDDALNATRAAVEEGILPGGGVALLKASQMLSTTGSAPGSSTSSSSTSPDATPIPVANFDQDLGVSIIRRAISQPARAILTNAGEEASVIVGSLLDQSKSPSFTYGYDASSGKYVDMIQAGIVDPLKVVRTALVDAAGVASLLTTSECCVVDAPEEEKAPAGGMGGMGGMGGMGGMGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C372</accession>
    <name>A0A8H5C372_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C372"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="10818" checksum="0141A11529DEF727" modified="2022-01-19" version="1">MLYPDEKLVIWSRTHSVHAQVGDPVGEVTGRKLVEDSVWAITLLAEPANVTFEVYAYTDTPSSSNDNIISSQTFSVQAGLTKLAMPIGFLDGDGDGGYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3G0</accession>
    <name>A0A8H5C3G0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3G0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5334562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="219" mass="24159" checksum="A85B1A2C68E1FC14" modified="2022-01-19" version="1">MATNTNTSTLQKFASACANGNLKEVQSILAGFTATRSTLHDHPLQHGLIVAAENGHDEIVKYLLGNGFRYLLSEDIFQAMINSGWDINQSAGHTGDALSHAVGADRTKLVKWLLEHGGNPNENYRSEPWTCLDLGVIHASTGTVELLLKHGANIQNTNSLLLACFYGRVEMINLLLEYGVDINEIPDNELTSDRDRARGLGNALHLAAREDREEWCKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3K2</accession>
    <name>A0A8H5C3K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_018429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000255">
        <property type="protein sequence ID" value="KAF5334590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3K2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5334590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="652" mass="71607" checksum="E5C456B773C3F13F" modified="2022-01-19" version="1">MPVERSRTRRTGADGTQLVWTMPSTNSPTAESTVSFASTLTPITFSHPGPDGLSSATLPVQQQTLFPFVDESSSPFSTLTPASFASSSDSDDAPSSSRNNNKGSSSSSHSKKKPENHIPRPPNAFILFRSSFIRSQHVSTRVETNHSTLSKIIGLTWHNLPEDEKQVWHARAKVAFDEHKKKFPEYSFRPAHSSSNGDDGGGGKGGKGKAKAKAKAKVKSGGGKKVKTKAEPDVYHADADLSDSYDDSYLSSYDSETDIDSGYASNIPSDPNPPKKKRKVRELGTKDLKRCAKIAQLLVEGKKGSALDSAIIEFDKTHVPEPVVARWEKPITEWSFRKKERKEKERKMKEKERDRKKAKQVVERGMTIESGFSSPSPSSYASPPPPSSYASSRCSSPTKPSTGVFNVESFGDEEDTAPTRRPSLTINTDFSFIQPNTDAQTFVHPSPSPYAQEYPASAYPQSSYPESTVEQYSAQAYTSPPTPIIPSTPVSSFDYTSWNSSLESVPSLTNSASVSSSSSYEDLNAWGQQQQQYVPQVQVHQPVVQTPAHIDYTQVYEPSSYQSYSSDEFGYEEFLTQPSPAMEFGPEEFNVQALLDKMQMQMQTQTQIQDTQMPMSMTLDFSGGESMGLPMAMDDVLSGMGMYAGYGGEAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7S8</accession>
    <name>A0A8H5C7S8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000228">
        <property type="protein sequence ID" value="KAF5336279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7S8"/>
    <dbReference type="OrthoDB" id="3217549at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="542" mass="61012" checksum="D2B21BAA723EA2C2" modified="2022-01-19" version="1">MSSDKNHEVMDPNTTLHSLRGLPCPLRVRSARALLKDARKEVEGCIEKMRRSGGGAIAQREHDRLVVLVDELLGCISPIRRLPPELLELIFSFSCYKDSELYACLIPVPMRLAQVCGQWHRLAHSMSELWTSMIISLGLRDGRGLRSDIFKARLDLFLQLSRERPLRISLSIQTQSPLAEHVLQTLSGHSPRWVSLDLKCIASLLVNRNFPNVKGNLPLLKDLKVKYWPDNRSILACTVFDDLPNIEEVIIGEDVFTGHSVAYIAKNSLSHLILTHNGNPRPAIFGRGPFRLTALQLIAKYAGNPNQTVISIGNPLLIPNVKSASMYASLSPILGLLALPRLIQLEIDGGPGYILLRGAKFIMPFLNRSSSHITSFSLLNIGIRIDHLVEMIKALPNLSSLTLHETRALFDRNSWPHKDRAIFNHRFFKYLTVDDTKPSLSTVLPHLRELDLQFDANQFPKDAFLKMLHSRRRVGVNARLGVDNLTSVTVRIYGGHYVYPFLRSCWESFEELRAAGLRVIEVVKDEVVDQGSRPREIYGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAU3</accession>
    <name>A0A8H5CAU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_012225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAU3"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5338417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="492" mass="53093" checksum="1C4A4FA8564D23EE" modified="2022-01-19" version="1">MLGLKALTMATSDRKTPPIGLKWRSSYWFITFVVSLGLATDMLVYSIIVPVMPFHLEELGYDGVSGLSGWLLFAFSAGLLIATFPAAMFSERYDARQSPLVLGVIILVGSQIMLMEAPVYWLMVLARVLQGVGSTCVWVVGMALICDATPKEIVARQIGLAMSGFSLGVVVGPPAGGALYERFGFRGPFIFWNNYGRCGSNCAAHCCREEGCIEMGCRSIEGDETRRQCSPDQAANATVPDENGANVQAGGADEKASAGLAESEKEKQENVPREKPLSLLPVLGRLCRSPRAMNASFMALVYGIVYSCQEPTLPLHLQDVWSFQSGDTGLVFLAGVVPTLFSSPLTGYISDRFGTAWITLACLLLSLPWWIVMIVELNVVLFIASFSIENLFTSGILSPLMSELAAVAREDEGIGYAHVYAAFNLVFGIGSAVGPIIGGQVYDNSRRGWMIICILSAGLVAVGMVVSSIYTGEEPVVKRLLRAMKRDKSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAW1</accession>
    <name>A0A8H5CAW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAW1"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="811"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="913" mass="100510" checksum="FDBC36AD0D7C35CC" modified="2022-01-19" version="1">MSDTPTQPGFPSLDAHHNEGLVQRRIRHVTSIQISNLTPFPVRDSLTAALHKPTEQHGHTSDDLDASMSLKRSRRVSANSITTLRSLRSDDSDSVQAGYDRGRRRRDSKVSFQEENHPRASSSAGRTAPTIRPHRVRTTSAVSSLFAPHNIGHEKVDHRFSVSPEDHSQTALEKIIQSRLPTVITSKSTFPDLDATSFSNFPEILTEFRDSSHLIANGRSTTRSPASKRKDKPTPLDTSQPSGSRPPSVTSSLPDYISPIHRPSTNPLFPIDARSEMPGADISQDRFKVVLWAKIGADRKDTKDVNGKGKAKEQSERTAVDDWQIVEEWKVDLNDLMPLSNDSVSPSQLPSNTLVLTLDPPGRRFYVLSSHLQSLRPPSPSAGYASDPEADLRKVKHLSADDSIDNVQFTGKRRHRRGAKDESATGDLGTSSGWQDLFNLVTLQSLVIDTEASLAEIIRSIDYAIVSDTHTRLKREISQRESRIAELQENCESVRSKSQHLRDQIRLRREELAERRSRLLLAQKQEDDVLRHRAEIEEDVEDERAQLESLRTLFTPTRTALISALAYIYPIELLSPPDLLYTILDVPLPIPLSSNEPAPPLSLPNHKDIDEETVATALGYAAQVVQLLAGYLSKGLVYPVTCIGSRSLIRDSISAMVGPRMFPLFSKGVDTYRFEYAVFLLNKDIEMLMAEYDLRAMDIRHTLPNLKNLLLSLTDGSEVPSGPPKRPLSPMSSLSGLESPRAESPAPGTECSQTPTTVENNNIPGDSTPPASGSTTPTAVSMDTVKRSRFLALPPLSGFLRYPSSLLTRNTDASETVEQGNGETPVQAVSQESGGESQEAIDGDDEMDRRTIRSLGRNSDHEPESMEGKQEMETSLSPKANGKEKSSKIQQVAAAANPIAAAPLSGRVGVDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB41</accession>
    <name>A0A8H5CB41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_015703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000205">
        <property type="protein sequence ID" value="KAF5337831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB41"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5337831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="555" mass="61628" checksum="2ABEB2BC3BE47B10" modified="2022-01-19" version="1">MKNSKLLEGRRLYHTVNFVAGLAIFFFGYDQGMMGGVNTSPDYVRTMGLGTSSYQGPSEGYVVHITEPTKQGGIVSIYYLGTLLGCLMAGVIGDRLGRIKTMMIGGIWVIIGAVLQCSAQNLAWMLCARVINGIGTGYLNAIVPVWSAEVATHTSRGAFIALEFTLNIFGVVVAYWLEFGLGFIGDGRSQIRWRFPIAFQIIPVTVFMVALYWMPESPRWLIKAGRIDEAKTILRRLRVHESPATHATDSPAGTPVDETGEKGHSIAEAEFNSIVEVVKLEQKHSKMNNYWNMFWGIGSGDLHIARRVQLAIWLQIIQEWVGIAAITVYAPTIFAEAGYGARKSQWLSGLNDVTYMIATLLAVVTIDRWGRRVGLWWGSVGQGISMILAGAFSRLLRDHPEKASQYGGAAAFFVFLYTAIFGATWLTIPWVYPTEIFPLEVRARGNAWGVVGWSIGNGWLTLLNPIMFNAIQENTLHIFGAINFLSIPMVWALYPETANRTLEEMDLLFASKSPFVWDEERNFKRLKEQMAQTGKGVDAVIAKPAEDMANEKVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CFJ3</accession>
    <name>A0A8H5CFJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000178">
        <property type="protein sequence ID" value="KAF5340156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CFJ3"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5340156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="16073" checksum="48F12BB12B89403B" modified="2022-01-19" version="1">MKYISTELRKSSLASSLRSKNPTRYLVMHGITWDGDAEREKVAREWAETSVTELKKMEGWVRTTTFRGIDILKVGLGIPEGPETQKMPISLTVHTDGFLTPEAAESYAKQVAGHTNSAPKVSITRIEFGVCIDTHMMLVKGIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG50</accession>
    <name>A0A8H5CG50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_015030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG50"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5339937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="398" mass="45613" checksum="DE52B242EF153B59" modified="2022-01-19" version="1">MKLYFYLQLLFPAHSLNYPFDPMDPSAVEFRAFYPYTPNEVKHRKRTTSAQLKVLESVSKRDTKPNAALRNELAVQLNMTARGVQVWFQNWRAKEKIKTSTTASADKGREAKKQEQKKKQQQLYVQGKDKTVSPSDHNQKADGYYHAPKTPCKRALLVGLRPGDRKKPSFKTVVMPWIEPYNYLPLSSERKEEDNTGCMPLRIIRGVRDGLFDDDAPREHLQQSELTTALLVPSRPYIQANPRDQSCRGQANRRDKANRRDLEEPSRIAILANVPISVRPTGSLNGSSSFFSNAHGFEATHPTFNNAQTINVTINNFNGHTILRPEDPTYRDLELKLAQTKEQLTQLKIENLQLRNTNLELRLSQLEQLRQRIPPEPPPPPDSLSRYLYTFLDTCNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM78</accession>
    <name>A0A8H5CM78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM78"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5343222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="40438" checksum="6E09B2080F1B395B" modified="2022-01-19" version="1">MSLPLNDGHNIPTIAFGTGSKWKWHDVTTYVQLALESGFSHLDTAAFYETEPFVGRAIKESGLARKDLFLTTKCGLMIPLRKSLKDSLEKLGVEYVDLFLIHNHFFVPDIKEAWKEMEKLKEEGLARSIGVSNYEVKHLKQMMRVAKVKPAVNQISLNPYNYAEMKPIIDYCQENGIVVEAYSSLAPITTYPGGPVDIPITAAALRLGITPTQVIFLWVRAKGAVIVTTTSSKERMKEYLAVNDLPPTSLTHEEIAAIDHAGANGPPPGPGPSSQPESTSFLSSSSFHLSPLSRILSSLSSRPSPSPSKDVGVDVYVDVEKSPLVTLTTPTPCHPSPHPPTKLTLVGVINILLVSITFILGIVLVLMGLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMG3</accession>
    <name>A0A8H5CMG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_016478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000123">
        <property type="protein sequence ID" value="KAF5344526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMG3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="59"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="330"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="690"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="722"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="818"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="851"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="887"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="917"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="953"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113737" checksum="B9EABBF60A0426E0" modified="2022-01-19" version="1">MKMFNQASQFTITQSSITVIGGNQINQGNVVGSPKDLKWINAPNPFENFYSAEQKIVQGTGTWLLEHRLFQEWKTGMSPFLWLQGKECEVEGTLNILFSTNVIKTLRKDSVFLYYYFDTRNKAKVDYSGIVSSLLHQVAAEAIRQNSENAYNAIHQLYINSKEGKFLIPEDMESTLLDLIAMMDAVYIIIDALDECAEEGKLLALVDTLLTKLKNCFVFVSSRPHINTTHNKVGIISLDKQMSDVGITSDIEKYVDTKLQKQHAWSPELKAEVKDTLVNSANGQIRWVDCQLTALNEIKMPRGIRKALKSLPKTLQETYAKILEQVKDEQKDYVKTIFQWLLFAYRPLTIGEVQHILAIDVEEEIFRPEDLLENIETELHNVVNSSLVVIIQASTEGYRWNKQNFLTVQLAHPSVKDYLLSEAAMQSVSGYFQMNSALAHEAICQMCIVYLLCCGQEAINVEKCALAHYASKYWILHSNQTKEECSAILDLSCKLLSTTQPAYYNWLNVYTPDTWNNKPIYIAQPLYYAGYTGLKSVVMYTLEKGADVNAQGGEYGNALQAASLNGHLEVVRALLEKGVDVNAQGGFYGNALQAASYEGHLEVVRALLGKGADVNAQGGPYGNALQAASLNGHLEVVRALLEKGADVNAQGGEYGNALQAASCYGHLEVVRALLEKGADVNAQGGFYGYALYAASHDGDLEVVRALLEKGADVNAQGGGYGNALQAASLNGHLEVVRALLEKGADVNAQGGHHGYALQAASDNGHLEVVRALLEKGADVNAQGGEYADALQAASFNGDLEVVRALLEKGADVNAQGGYYGNALQAASYNGHLEVVRALLEKGADVNAQGGEYGNALQAASYNGHLEVVRALLGKGADVNAQGEGYGNALQAASLNGDLVVVRALLEKGADVNAQGGYYGNALQAASYNGHLEVVRALLEKGADVNAQGEGYGNALQAASCSGHLEVVRALLEKGADLNAQGGEYGNALQAASYNGDLEVVRVLLEKGADVNAQGRKYSSALNAARYRWHSKVIAALLEAGAVDDVYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CML0</accession>
    <name>A0A8H5CML0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_016480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000123">
        <property type="protein sequence ID" value="KAF5344540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CML0"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="251"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="454"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5344540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57100" checksum="AA93890E1A8EFB7F" modified="2022-01-19" version="1">MRGDKGGNGGNGDNGGKGDGEGKGAGVGGGRVDADAVPGTAMGMGMGGKSVAGSGERTRRGERNPSHGWTYRNRNSYRRRRSNRRRRSKHLHLHLHRLYRRPHCTNRTPNSPSAAAKKLKRKRTLKNTGSTADISASVSTFIPTSSSIPTSLVKVKGEKLHDPDTRQSTSIHWHGFCQARTSYADGPSFINQCPIPPGNVFHYAFDTAGQTGHYGYHSHLSTQYCDGLRGAFVVYDPHDPLRHLYDVDDDSTIITLADWYHDFAPDAQDRFFQTGTVPIPDSGLINEVPFSVINVVRGLRYRLHVFPISCRPFHTFSVDNHKISAMEFDGVEHDSVTVDNFDIFAARHVSTILHANQPIGNYWIRAPPTGGAAAGAPNGNPGFNPNLTLAIFAPNREPTTNNTGAAGVKLNDGDMRPIASEGPGQLGSVPADVAFNLVISQPKLPFFDINNISYISPTVPVLLQILSGAAQPQDVLPSKQIFWIPPNATIKISIPGTGAHPFHLHGHNFDVIKVANSNVTNFVNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN75</accession>
    <name>A0A8H5CN75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN75"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034520335" evidence="2">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="181" mass="18204" checksum="67BBE165A9982E64" modified="2022-01-19" version="1">MMFNGNLKFKLLYLFLALAVLQVTVNAAPRKSLKAPTSTSKTSSLTSLSSTSTPGSISTGSTTSSTSSKPTASTTSTSSSSSSSEVPTGTTKSTSTGTRTGTESATTSNTNNSTVPTSGPKNSTAPGGGKNATNSESLDGFKVLNSCPLSSSKKNDSSSTNTTTGKPKTTGKPPKDNKVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNI7</accession>
    <name>A0A8H5CNI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNI7"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5344146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="222" mass="23955" checksum="C3F8A77813441FD0" modified="2022-01-19" version="1">MTDNPSFVLRAIDDVAYEQRPIPEISDREVLVEVKKTGICGSDVHYLAHGRIGDFVVKDPMVLGHESAGVVCKVGAKVSHVKVGDRVAVEPGSTCRMCDACKSGRYNLCPDIVFAATPPYDGTLGRYYRVLGDLAFPLPDNLSLEDGAMMEPLSVGVHSVHTLGNFRSNQSIVVFGCGPVGLLCMTVAKALGARRIIAIDIVESRLEFAKSYAGAEVYRPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNV2</accession>
    <name>A0A8H5CNV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNV2"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="519"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="613"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="932"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5344898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1135" mass="124651" checksum="9AE0CE74C85C792D" modified="2022-01-19" version="1">MSTIDDPVLEPLPDADSDDELDWEEVPVPEEQKHLEIVIQARPKEKETPSAKKGISHAERLLRIDVHKVHTVTLLLNAKIRNRWLNDELLHARLLSLTPLSLQNSLAMIHPSRVPEQAKRGRMFETAVGHLVEWWSQEFFEVIPEGHIQNRTFDSIQKGLISHGFGPDTPEDKLIDDETLEDILDEDAEIIRSSKSLMKHALMQRGSRDLCARGLSIPARLVVSLQSVPWQASVGKPKPKYVKKDKGKAAAKGDMSEEQSEMLEDSGAVASSSKSTIDNASEFKGEGQRLDGAPVEKSEKAKGKEKAKPPIKLRKTKSKGNVLGSKPAPPKVRYIDPRISPPVFWTEVFSRPDSRWIPVDPIRGIVNKSKVFDPSDTPSGVHVDNRMMYVLAFEEDGYARDVTRRYAKQYGAKVAKAQGGSLAPGAGGKGRAQWWQRVVGAVTRPFRLNRDDLEDAEFEQAQWNEGMPTTIGGFKDHPLYVLPRHLKQNETLYPSPPATPELGKFRGEPVYSRSAVVLLKTAENWLRSEGRSVKEGAQPLKLIKMRASTVGRRRELKMLKEGLRVAGESGSGGGDAGAGAAGASKQQAEVMQGLYARHQTELFVPPPVIDGIVPKNNFGNIDLYVPSMLPRGAVHIPFKGVAKIARKLGLDFGEAVTGFEFRKRIATPIMEGIVIASEHETVVLEAFWEAEQESERKARAKREERVIKQWTRLIHGLRIRQRLQAQYASNTTNDKAAETTPQGMDVDRESHQHHDEDESHMHLTGEGGFLLRGADDVVQSYSLPKAQHFTPHFDIAGPSGSGLTSTLTLTSMMSNLDKGYDTNGESKRKDVRSGPNARGGASEDLDSGHDRMAFAMETMDVDDDDDVHMHLNPTSLSLRHGHSLPSAAESTSAEFVPKTMEELAEEAVRANGPGGHAEDGEVEEIDIVPTSTLVGKENGAGGGASSGIGRSTRRGAARATVIHQVNDHDESTAEPAVNGNTKRTTRNASVRGTSRGRGRGQGRGKGAAAGRGRKPKKSTRKRKRDEEEDKEDEAVSDDDDDAEMDDHIHLEADDDEGDGGGDDGKDKGPAVKRKSSTSPAKRTRANKTKTTTSTVPVPVPIPTSTRTLRPRASKTEAQLRGEKEMEEAYRRAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNZ9</accession>
    <name>A0A8H5CNZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_013252</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNZ9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034868096" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5344363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="636" mass="69116" checksum="E006D7F6F3D97109" modified="2022-01-19" version="1">MSLFLPILILAFSFLTYASPFSFPDSDPTTDADSLVDNFNFDYIIVGGGLSGLTLANRLTENPRTTALVLEAGSLHFDDPLIDIPGNVGMVLGNASYDWNFVTVPQENANNRSFAFHRGKGLGGSTLINYMVWNRPAMAELDAIGSLGNPGWNGTDWFKYMRKAEDFAHPDPSLAASENLTFIPGAHGNSGLVHTSFPLFISDAQKPWLPALMELGLHHVEDALAGHNVGIWMGPANINSKTQKRSSSAEAYYRPFAAHRPNLRVLTEAPVTEILIPDRQSRNGLFSVTGVKYGYKGQTRTASVKDSKGEVILSAGFGKSSQLLELAGIGDPKVLQPLGIDVKVNLPGVGIGIIDQLLWGVSYELKNSSIVTLDDIKDPELEAAALAEYNANKTGVLTIGVTAYSLVSLDDIVGHSKATEMINKQAAKIARLHVSEIQKEKWNIIINGLRKPKEVGLVEISGFPAFFTTASTPEKGKKYLTFLGHYQFPFSTGTVHIVSRDVNTQPAMDPHFFEDDFDSQVFIESTKLIRKMARVGEFVDVLGDEIDPGMDVQSDEDILEYVKNFSATAYHTAGSAAMLPREKGGVVSPELKVYGTTNLRVVDMSVMPLQVSSHPMGTLYGLSEKAADIIKGEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CP24</accession>
    <name>A0A8H5CP24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CP24"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="246"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="608" mass="69279" checksum="8DE7FF1230AAE206" modified="2022-01-19" version="1">MSVYGHSSNIHIAHRENEEIFDRVPLPDPSISLPDDPKLIPDIDLLIYRIYLTMQMYQKLLQVYQSLSEQIVLACEPYARKSLAFKAADWEGRKGYRNRAIYSWYHKLSKEIQRYSESSLKDQIVCHNDLKRTILRYHHSMPDEVSDMSPLDQMTQYTPKFGAFDSEELKEPLSILLSSREEAQALLSLKDRQATNFLDLLDKMMDFVEPTSALYLQCLRRLRRLCGVFGALPSSCVLNSEKQLEKTSTEALLSGGFADIWRGKYEERDTVIDVAIKVLRIYGKENLQVVRQRFCREAVLWRRFTHPNILRFLGVSTTLFPLCLISTWMSNGNIMSFLRAHPQANRVELLVDIGKGLKYLHSIGVIHGDLKGANILVDDKYHAVLSDFGLTAVTYDPHTVNAITTSAEVMGSVRWMAPEVINPDEAESRRQSPESDIYALGMVIWEVFSGKVPYHQWPRDATVVFKILLGIRPERPSDASALGLSDAVWNVIGMCWQDWRKRPRVLSVLQCLEEAFKDFIPPPFVPPAPKSLHPLPLHFDAEIDDEGNDIGVPFLQDFTNVPDNIMTAFENLQISQASQVPQTSAAADLLSGDNTSLVLELEWLDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPW0</accession>
    <name>A0A8H5CPW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000123">
        <property type="protein sequence ID" value="KAF5344527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPW0"/>
    <dbReference type="OrthoDB" id="3265199at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="79"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="325" mass="36119" checksum="A3FDE2AA0B279D60" modified="2022-01-19" version="1">MAPSCTATYCNMPRTRCQTAQIPQEPESSESPEPESSPSSQAESSGDEGSGTEDEHTSADEADLDGDSQLEDIGTNSKAGNHQSSNWLPWQDRALIQQVNKVWPFEVKGKSGQKWEEVSHDLLQSQSEDGTKKTPIQRSGESCKRRFNRLIEAHQLMAEIYSLFIENQSNVKSLSAKAQQKVQNEANAGLELREASMKWECHCTRASRATTVRRCVESDSDSDSDNKENLEPKRKRVPTSVATSVKDAIQQHLDNNDSAVQEAQERESKRQEQTKALLTKVVESNDKVAESVSQLVNAVNTMVDTQQKENANGQSKLLDALLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ21</accession>
    <name>A0A8H5CQ21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_011420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ21"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034134338" evidence="4">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="15065" checksum="0C25BA59C89FA409" modified="2022-01-19" version="1">MKFFAGVISIALLPALTGAVQLQFDNHYDDAGASLNTVACSDGANGLETRFGFKTFGDIPQFPHIGAAAAVEGWNSANCGTCYKLSYTNANGKTKSIHMLAVDHARTGFTVAQAAMDELTGGQAVALGRINVTSKKVNIKHCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRU3</accession>
    <name>A0A8H5CRU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRU3"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="98" mass="10992" checksum="4C4AC83DB7B189A4" modified="2022-01-19" version="1">MLLSSTILQIAPVVYQAAERDAETLYKDGQAKLGTDEIAVCDILVNRSTPQLIAIVDLNRRNYKSLAKLWPYVHHPPHIVHTVKPKHLFEGVGAWLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTN3</accession>
    <name>A0A8H5CTN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000095">
        <property type="protein sequence ID" value="KAF5347418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTN3"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="70" mass="7555" checksum="E0B283DB39E39B6D" modified="2022-01-19" version="1">MDLDEGLGLDARLKRFDESAASGDKSRLVVWAGQGVGLTEQGYFVCDVVKQLHKDAVSALESGFQLVAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUA8</accession>
    <name>A0A8H5CUA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000096">
        <property type="protein sequence ID" value="KAF5347198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUA8"/>
    <dbReference type="OrthoDB" id="3515175at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="355" mass="38856" checksum="6D72472090756875" modified="2022-01-19" version="1">MLSEAWPGEYDAEAEVSVDTASATADRVPSLFELSIPSAVEHSLSINDTKRLEELAWMPGRADHLKKVLMGKKPFPDSGISLLEKILEHDFNKSDNFTLDLSAFTSLSSEQIALLVKEVSGAIPNIKSVDLSGNQNISAATVAEVLRAIPQLLRLVLLNTSIENEELLNLLFSSPTLFYQLHDLVHLAFLRPTSVDYGEKVPSPEKLHAAYLHGLTVIFGGTFGKDISTVPFFNTEKLLKILTHHFQASHCQDPMFAFSYTQSNLGSAAVLSSGTTIVAADKGANNDSHDAKASEPIVLVDGLRLTTLLNATLPRFFSVLSNLIFSRFGITSDPASRYDDWSSRTISSIPRMYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CV65</accession>
    <name>A0A8H5CV65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_006789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CV65"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5348651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="553" mass="61807" checksum="0506AE53FD7736C8" modified="2022-01-19" version="1">MSSSSEYFTVCCWFSMSSHRPRKARRTDSDSSQEVSLPPISHIFTAPSHEYDESVALPPLRTQNTPRQVDPHSHAQGYLASTPRRPFQMVTPPGAYPYSENLGSRRGTTPTRSNHTSFPHQMPTSMHSRYQPPVAQQPYQAVYPDRYPAPISTDTHRDRGPGNAGMNAYPSAPAMYGVSASRSPPLLASPQAGSSSPSYSRNVTIPHAPTSSTEDLPFGGPKTKYECSYCGKGFLRPSALKIHIISHTGDKAGTVIMAHWNRSDRPSHMYNAPHDSDTNPEDRPVLPSISRIFDNGSTTRGHHPSLTLPPLPEAERRQQQYEYSGNRNRVENVSQYPYPSPNVNEYDMRSQGHTPGYQPQNQYYTSSRLQDTQSDPRFSSVYQTNQAMSALSSAHSVTPQQYPATSYQSNPRNMPSYHTDPRYAADPRYAVPQASYQNDYNDPYASQYSRGYPDYMRGQSNSPVTAYSGATTGSRHQCSYCGKRFSRPSGLKIHLTTHTGEKPYVCPEEGCHRSFSVRSNMRRHVRIVHQYSLQGASDSGEDGESREGDPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZC5</accession>
    <name>A0A8H5CZC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZC5"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="70759" checksum="CB756A74FDA403B8" modified="2022-01-19" version="1">MNLKEDFDTGETVVQIKGPLFFRENIDYSPSSPSPEYDLNLHCANRPHIFHPASNQDACYIPENGDDPWVPCTTQLCLNRYNTQRLTNVELLSWLHVITQLQELAIQKAHQKPKTKSGQGTPTPTNQPSEPDPVPETPPNNPPEPNDPTSPPSSPTIPSAKGPSVAPHRPPTPPSPNPSDPNDSVMADTPPIGSNGTSERGRKPDAFNGERSEAKRWLALFNNYLRMNKGKYPTEESQVSLFLSFFTGEKGGDWATQRLIERDEDEEDEDLASTPDKWRWITLKQIRDRFKKDFKALALKDVARTKIKFARMKGTDISSYNSIFDTYGEESEFGEAALLEFCQDGLPPKLREAVGRTYPKWDDFEDYKERAVELHLEWLKERERQGRWKTTSTSKSSPGPSQGRTVASVNALMNMGPAQASSSRNTIKDISDMVNRVKGLEGEEKEQATIPSITLKTELIGKVTGRKIDANALIDSGAEGIIINGQFAQKHQLTLLPIKNPFPVRNVDGSENTMGWVREYTIQNLRIYSRDSEAYHEEKAEFYVTDIGDHTIQNLRIYSRDSEAYHEEKAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVEPSQLTFSLSLFLSLPLLIKSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D151</accession>
    <name>A0A8H5D151_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_007810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D151"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="384"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5350257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="600" mass="67856" checksum="B85A6A4FB309A406" modified="2022-01-19" version="1">MPVRSLPPPAKRRKVEQSAIAHSIQEHEEQLTAAVSKNTSLNALADLVDLAQETVDPQDISKAIYALYRVFVIIITSGKLSLGGDESTKVVKAWIWERLNIYVDLLASLLQDEEKALRVSSLQILFSLQKHLSSSASQSSSPPSPQFHVSHFKKIVSALLSCPPSRRRVSDNVKASGKIEADVLTLFLDTWFNIHDDVRWFFLREAGTMLTATSVQNQPFMPMNLLSILEGLKTFPTQTSELNSWWVPELGQKPPKTKKASKEDSNDSDEEEVENQDTDDDWRKFFDEPEAKGTSKPKGPIGRVHTLTIHQSLHHLPSHRAVFTRAWLTLLPKLTVPHDLEATRSLAMRALNVMHRGVMPHLTRPVLVMDWIGACVDYGEAVGLLALNALFILMREYNLDYPSFYTRLYAFLDRDVLHLKHRARFFRMMDMFLSSTHLPSLLLASFVKRLARLSLNAPPSAIVMILPFTYNILKRHPALMIMIHRDGDSPHDPFVASETNPLLTEALSSSLWEIQSHRSHYHSSVSTLAKIFSEAFTKQPYSMEDFLDHTYATLFDTEANRKIKKEPALAIETDQQSKSNFVNSDEGGDVVHDLWTFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1B5</accession>
    <name>A0A8H5D1B5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="1598"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1227"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="767"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="848"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="904"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1262"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="1822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5350347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2055" mass="214384" checksum="7768B8F0754ECD5C" modified="2022-01-19" version="1">MPRAKAQNGSIKRASNRSPSKSDQTLNPPLPTPTPTDTIIVKTERAESPIIWFSPSPSPSPSLTSPSQKLLYGWQHPSELDYITPHSWSNSKIIHYLIANSFNVPPREKNIRGSRFTSITATNGSTIVIPMGYRIPLMFIARFQWLSLKLVLTAAEGLKEKEWNDYKFGILHVSRLCKVFFDKAQEQLGWVEGAGRLRGVDRKWRCETFDRALARYRLKWFLSDPSQLAEFWETYQEEEYQKDILQYNWRQWAVKGHRGFALAEDEISNGFTAQQLMAGLKFVKPSPSPTKTRNGKGGADEGSWHWETEEAPVPGGIDAWDLRVEAMREVGIGVVKGVTTTTATTAKKKEKTTSASSTPKPSQTQPLPQPQPTRPGTVIPQTATYFPTIPYPIPSSNKSSSSIPSKRPGSPLENPNPAAKIKLQTKRSTASASSSPPASIAGGSNQTQAQAQALMKTKAFYVPHTPVAGNAGKDASGNGTSANANGGTAGAGGTKASAALPTPPLTAAGAGTATAQAPVQGPPGLFTSTPLSMPMGVAKSTLSASSPSNASSPKIKIGPLNPKQNQSQTQSQSQSQPTPTASPHPHPNPNPNTNPQQLSPTTTTTTKPQVQGQGQGQGQVQVVVPTLAQAKQAMLLEEMHKEREKEKDTSSASASGSGSATTSLTSSQQLEKESEGKEKEKGKEEKEKEKATKDGLKDMSVSPTETAPRDTFTSTSASTSTPTPTPVTVKTVNPATVNTTHKPVFYGPVPPPGHGSVVYGPVPPPLASSLPSASKTTTTKSTSTSVPGLGLGLGVVSVSAPAPVSGKQTPAPTSGSSVVGGAANGAGTFTTSTSASAATPAPAPAPAATPSSTSSTPNPTPNSNPNSTSNSNAAAAAASPAIPSVSSLVPPVSVPPVSAPLPRPQSQLQPQPQPQAVQGQSQASSGEQAVVVGSGSSSENDRVEDPTTPAAPTPITPPSLLPVSVSLSVPASTLGGSTTSPSIGQNIGRSTVGMAVDGKYSPFYHHNPISFYMNPNPNPNPNPNVGSGSSGGVGGGVGGGMGAGAGAGTGTGTGGMSVGIGGGGGVGGGSSASGGAGTAGGMRKNGNVNGNPPTSSPLAVQSTDPSMNATMGNGMDGDGKGQGMATSVKGAGSSGGVGEGSGDANATASTTSTSTSSTTVVPTVAAPVPVQGDSDATPVVLSQIPISSSSGGAGGASQEDTRMDMDVDVTTIPAPVTSNTTGSVNGWNSVVASPEPTTSKITLTIPPLSRAASRNGTATPKNSNTQNASTSTSTTNTTSGPSSSSRLPNSTLASPETMVKVIDSLFTGFADTLRKFSSEISTSRDDTVRSLSSQVKTINTELKNLQSSLRTDFQSDVRAAVRQELNWELRAALRADTKRDIREGVREEIGERDREVMGKVMEVWEELGKLRKEVVYSLNKQSSAAFLNHSQHQQLQHQGQYQSQYQHSPQPQIVYVQAPAPGPVVINGICGGRVPHPLGHLLGEPDPSIGDGMDLDDYEYDGQEPDVIGMAELERMNSARGDMGYDMEVGSASPMPAKSQRKFQKMRMGTNSVDQTPAGSPADSDYPSRVLSTHVCIPLASVSFRFVFAHWATTPRSATGKVLTKVSVGSAKDVDIAVDAAKKAFKTTWGLHTPGSRRGQLLTKLADLMEANQDELAALEALDAGKPFPMAKSADVAAAIGTIRYYGGWADKIHGKTIETTEAKFAYTRHEPFGVVGQIIPWNFPLLMLAWKIGPALATGNTVVLKPSENTPLSALKVAGLLNEAGFPPGVLNIVNGLGPVVGEAIAYHPHIRKVAFTGSTLVGRKIQEASAKSNLKVVTLELGGKSPNIIFDDADVEQAVKWASIGIFANMGQVCTAGSRIFVQEGIHDKFVQAFTAAAKGLHGATGDPFSSTTMHGPQVSQIQFDRVMGYINDAKQEGATVSSGGEAHGGDGYFIQPTIFSDCKPSMKIVQEEVFGPVAAVIKFKTEEEVIEMANDTSYGLACGVFTENSSRAIRVAHALEAGMSWINCYNTSEYQVPFGGYKQSGIGRELGEYAIETYTQVKAVHINIGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1U9</accession>
    <name>A0A8H5D1U9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1U9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="387" mass="43431" checksum="70E033FB18EC9B7F" modified="2022-01-19" version="1">MSQPTMSQSQRSDYLEPLENPQSSSQWSMELVADARIPSPSPNTQSQEFHVDYQGSSQVSSQFGDESSSQTIVTPSSQTIVSYQFIDDFGSSQASSQLTSQPSSQSIVLSSHQPIDNLASQPSSQFSDQISGQFLSQPILPSHEAILLSNSQPPVPPRHPVAATTMLRPDNADPPNVQQEKNASQNLEKLAETPPYARSFNLKMMLQNPLPRKWLILKIYFKWHNPNPFGQKNTARFEIVNPDGSVAARFSLEGYFGFPKAVLYLQSDEYSKDEHFDVRLRYHEGGFGGIVNPQMDGPSTSELSALEVGECWPPQQLLADAPQVLLKAYIRVTEIEQNEQNEEQVTQWTQWERERSTEEEAKWSEGQQIEIKYQTSNQQNAQTDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D253</accession>
    <name>A0A8H5D253_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D253"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5351368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60614" checksum="D8F52E746BA4A93C" modified="2022-01-19" version="1">MHSNMKTTRVGVRPNFTLFLCISLFLSICVIPMMFAYAAPTSVEPLADTQVLGVIVIARNGDRDQYWQDPKTYEGSFTETTALGEAESFQLGSLLRNTYLNPSSSSYIEGMRSDIVDNKEIKVRVKAGGEGTVIFDSAIALLQGLFPPNEKNKIVLANETTVVAPLNGYQYVPVETVEPVNDRSLESWTGCPNFQKHISEFYSSEAFKKKEKEADEFFKKARDFLFGVPATLENAHNIYDYMSTQLVHNKTYAYRLPPTMIEQARGLADFHENGVFSDKETGGIGNIAGRTMLHNVLKALERVAFNDDPLQFMLVQTGYQPFISLFHEIDMVKDQPELKAIPDFSSALVIELRRGSPPDLRDFLRFRFKNGTGSSFKTVYVYGTHSDIPLTEFIYKAKGGVISSNKQWAQECGRSRGSLLPSEFIEDVTDAARNQSILSVAVAVVVLAAFMLLVKFAKMTHQRVKDSRRRVRLQGEEVSFDTTSSVKSHAPRAKEETLIVDGTGYGSAADYGQCLHSRWYGWEMSNERAAGEYASLPSGIDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6X6</accession>
    <name>A0A8H5D6X6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6X6"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="244" mass="27886" checksum="139ECCAFF214C462" modified="2022-01-19" version="1">MAYEVKSMEVLKAVWDRGINTIDTTNAYSNGKSERAIGKFIKKYQIPHNEILILTKCHHLVHKDIGFTAANSPELSNTRDYVNQFGLFRAAIFHSVEASLRRLDTPYIDLLQIHRFDPNVEPEETIKALHDLVQSGKFALLNLVAERNGWTKFVSMQNECSLLYREEERDFAYCNYHGLIPWAPNAGGRLTRPLEEKTTRAAIFKGTPYYPDATDADKRIIKRVQEIAEKHGKSMAQIASAWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D773</accession>
    <name>A0A8H5D773_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D773"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="83" mass="9104" checksum="4849437638571221" modified="2022-01-19" version="1">MVFLGGRSTLSRRDALLLLIGATCMHLFTTIFPLSDSSIIINTHLHHDHAVLGGVDTEPLPPPPDKIVQNGRGQGKRCYVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EZD4</accession>
    <name>A0A8H5EZD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000464">
        <property type="protein sequence ID" value="KAF5317877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EZD4"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5317877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21736" checksum="5A343A7121ED0466" modified="2022-01-19" version="1">MRIKRRKLMREMKHGQEMTRKTTGNYCQSYDEDSPVTLRTQLETILEPDNTWVLHSYNEMMKCADLWMKPMEKKLAKLDSQKAFTPVLKPKMRKIITTQWVYTLGYDQVKGIHYDDTWAIVARYESERFMIAIATCEGLDLWSGDFTGAYLNVRPQGVNYLTLPEGFQERYSLCNGKKDCTPDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEK0</accession>
    <name>A0A8H5FEK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_017473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000279">
        <property type="protein sequence ID" value="KAF5333926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEK0"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5333926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="292" mass="29997" checksum="83440D481F1BC9B3" modified="2022-01-19" version="1">MSAVSASSSPALSISIPTFASASASNLPTVVSSEAPSSASTSALASSVSSSVPSSASASASASSVSSSVPSSASAPPSSPSSDVPFPPLGAPVNRHLVPIVPFNFTPFPIPSHQPISSIFIPTDPLSPPPVFDSSSPTSGTNPPTIPSFQDAWDIAYSKAKSLLSTFTLEEKVNVTTGVGWQNGLCVGNIPANEAKGFPGLFLEDSPLGVRFADYVTAFPTALMAASTWNRRLIRERGLAMGREHVGKGVNVALGPMMNMGRVAQGGTSGKASYTTSCNKGMKKTEKCMRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNE3</accession>
    <name>A0A8H5FNE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNE3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="44683" checksum="BEEABBDB91123D5A" modified="2022-01-19" version="1">MSLPLNGGHNIPTIAFGTTSLPTSNSPSSPVSPISTPQRSTKPNHSLEKLGVEYLDLFLVHNHFFVPDIKEAWKEMERLKEERLTRSIGVSNYEVKHLKQTMRVTKVKPAVNQISLNPYNYAEMKPIIDYCQENGIVVEAYSSLGCAGPVDIPITAAALRLGITPTQVIFLWVRAKGAVIVTTTSSKDRMKEYLAVNDLRADLRASSFVFLANRRGRVDFPPKPPPPPFHIISSFCPPSSSPLVITLTDTPHWLPFFPMPSSHLPVPLCATLIDTLHTFNPPQVLTHEEIAAIDHAGANGPPPGPSSQLESTSFLSSSSSFHLSPLSRISSSLSSWSSSPPKDAGVDLDVEKSPLVTTPTTATLTTTTTTTTPTRYRHPPTKLTLVGVISILLVSITFILGIVLVLMGLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNI1</accession>
    <name>A0A8H5FNI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000153">
        <property type="protein sequence ID" value="KAF5342913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNI1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5342913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="22241" checksum="4013B2E39367D989" modified="2022-01-19" version="1">MVLISVIEGDVWCDPPEYWEKVIWPAYIHAHKHILEGEDIMGNLNGKVKERVLLESIEGQYVDGLCAPLVLHRSQELYKYDKEFTVVLGDWYHEEHPVLLKQFINTDNPNSIEPVPDSAIIYFVQGTWYLSPKAGASPSPVTATVGFNESATLPFEPGRPTACTLLWKPGRPCLPWRASLTLSVSADQSAALIWKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNQ3</accession>
    <name>A0A8H5FNQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000148">
        <property type="protein sequence ID" value="KAF5343123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNQ3"/>
    <dbReference type="OrthoDB" id="3056903at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5343123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="664" mass="74787" checksum="5F6393A78194417A" modified="2022-01-19" version="1">MELQSSGSKSGIVYKLVGQMFSNKSHFQCVTLIPTTGGKSAVFSYDGMEHKGYAQQLKGKIAELLGGKTCPSGYHTICGVYSLKGGVAAQEKFHQDCIKTAHEKLELHLDGTQSATLLKDGYRSMTAEETKRWKPHSSVTEYQKTDLEPDQQGIQPLSESPATPSRTIPSSSPPPSSPLHLLCRCGTENDGHRERIKQESVQCDQCQQWSHLACLVNRSEPTIEGEFICHICSHQSMSAFERLEIRPPNCIQTQQDVANRLYAGRTVLVRMTAKDEFYYPGRLLHQEKQKWTVKMWRGIQHDNADKILEGIPLGKFTRTHEERDPQDVATDWQACPYNTEVDWALYKHKAALQDILVNTINSDFSKLSVAIVPALALYLENNTLGYTLPEGYIALTKKFGHPCPSYFTGGITTDDRARILNWIHKNVFSIGTLLKASDFDLCLAHARTLFLAHSQHETFLKHVEQGLSDQSIESSIIQQAWQRLVDFNGKTVDGKVEIERADVDKEALMILEAVMFDRSARAGKAGREQWGLDVGPPEDLWWPYDGPEKYAPDLCHATESDLVESERCKAIREKIEAERKAEQVEKEKNAPPRPRPRRLTKEQGLNRSKKALQEAGLLKEEITTKPAEPHQPHQSAGSKRRHGAEKGSETKDGNQSKKPRRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNY9</accession>
    <name>A0A8H5FNY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000133">
        <property type="protein sequence ID" value="KAF5343799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="4">
        <location>
            <begin position="274"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="557"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5343799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2016" mass="228532" checksum="0C858DFE745D7AD9" modified="2022-01-19" version="1">MIKDYDHWLLNPDNADCIARSFESLDSLGEFITSIPVKTRTKYDGVEYHIHTQDFQGQSNVLSNILCRFFVARFKVLSSLSNDDLAQVFLFYFPGTPCSSFVSEDRLSVIRKVLAHTFGSVTENLFEHGEDNCSISDAELQNLRAPIFDQADMYMLDYLEQRQHWPQEVPISTILSCVSTYHQKTIYIPAICCACCACDDFEYSGQYLAVSDFPSLTLLKWIDPFIVSHASPDTFTYADSSLNGALLSKKGVLSTDQGVKVYLCHLCLASLSKSSLPALSLANNLYRGELPFELRDLNITWAEEMVCAIYHTTVHVLRLYGSLEEDQPRVLHGNACAFELNTVSTANVLPWTPNDLNNMISVVFVGPKKLTLQELRQIKQLMVRKSVIWTLLNFLFLHNRLYHKLPPPCAAILNMYPDNDILPGLQDCIIYDHSSDAQTIFNQESSCFSEHPNATFLDPDADQNQLEAYSEHREAILEHLGVHDPRCTKIPARSMVSSALRNVNTNRDQSVPDLAIHHSYSFVSEYNNPDLISGMFPTLFPFGTGGFENRDRKPRSLSSVANAFNSLTSESLDKLAKRVEKEGYLQTMSSQDKVGFQLLKKVNAVAARIPGSQSAKVHTRNEIRSYFAYFGLPQLFFTFNPCAVHSPIFQVIYGDTSVDLNQMFPKLVSRYERARRLARDPVAGTDFFQFSFKMAFQHLLGWDFEKRRSTEAGGIFGKLRAFYGTLELTERGEFHGHFEIWLVGGMNPSDIHTKMRNDPDFERRFCNFFDCLIWHHLPNIEYYDDKNVEPRAERPPVPPSINQYSDLDIARNWDDTFQYEHKKLGEKVQRHRYQGVCFKGRPPGSACRFGYPHELQSRCEFEPDTNAIYLPIRDPDVNYHNPIILVFTCHNHNLKCILSGKAAKAAMFYITDYITKNPLSTGDILSLMSKAMASLENLHKKDPEAFPLADTKRILQKCISQLTSQQRIHAQQAARYLRGLDDTLPSHATTPLQSALLLDFVSNQYTNLLPSHQINNDPDDVDCLAPRIRVQIDDQGSIKTTNQVLNYWFRDEQLSQISFYNFTRSMTVERKRELKSHRSNIRPRFRFLPHHPLHNTHDLVLISNDFPSEPWKERVPIIIGKGVPRFGSSEHKLFSLAHFKPFGPQMPLIASSIDQEFESYQFSPFSQRVISNWEAIHECEDERDAERIYVTSSTADIAYGFQRHDSLITNLRACQWLMPPASDHHINSSSTLGSSTVLPSLSKTNLDNWTSLYKKAASDKATLQRAVSNPSSQVLTPTNCPNMSFDLNSARTYRPSEFDSVIPKTELIQPLTTASSTAMTPSQVLKYVADTNSLNEKQYQSFYIIASRFLQRYIFQDPEELNKDPLHMFLTGPGGTGKTHVVKSVQEVMKLYGMDHRIRFLAPTGRAASLIDGMTIHKGLGIQIKSKEKGKGNRKLGESEEDYTVCINVKKREQLRAEWKDVVLLFVDEVSMVDVGLFAHIDAALCFATENHDEYFGGIFLVAAGHFNQLPPVAGCPLYMPIRTQGISSQSEIERRLGRMAWKTITTVISLSEQKRTAEDPDYGAAVLRLRNRECTQDHVDLFNSSAANGPSLIECVAYDEVMEIGVKNSNHESEIRFSVKDAAEPSFYMRSELLKLNFSSQQSRILPGSVLLSVSIPGLPEKWFPILPQSSTFTVTIKDETGQARKLKCFRKQLLLQPAFTITGHFAQGQTLPVILCSFNDGPAAAYVSASQATERTGLFLLDEVTLEKLNSPKLPRDLHMEYERLEALEHNTMVEWLFIASDPVPVPVIEGEFLPSNIKATFNIDQKIVPAKRKQSNEANTTELHHVQHCKKSSITEDQLQNLTPPATISLHPNLSFTRSDLPSQLPLPGCVWDNLNWSCAYDTALTLLTYIFRDVTERFSQKWSSISTHSSMLINLLTENCVLEYSSLSTDMMNAMRETLRNYLTNYDPHHFVRSGPHMASCSSIMELFTTPFRSTEQCLLPLCCAKHNIEFLANIKIPFSTLPSLSSTGLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPH6</accession>
    <name>A0A8H5FPH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPH6"/>
    <dbReference type="OrthoDB" id="2741288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="45973" checksum="D95D64AA8C812C23" modified="2022-01-19" version="1">MAAITFEMSSGSSFMSTVPELTGPNYTIWASKSKSWLQSQGIAYVLNTLRPGEIQIVGSTSPIPAPPAAPAGTTGGTTAAEEESDAGSGVSSPHFIAAASGSVVDWEKDNDKAMGVIKLRVAQAIGAKIENITTARVMWDTLKSLYGRPGAAEIFQNFKRAMNVEIPRNTHPGATIDLIKMYLTRITNAGDNTEIPMYLQYMIVINKLPPDIYAYIIAKITQDDVDDFEHEMLDNLRTHVVNTWEARGGKKPQSANATKITAIKRKGKPPVFEEQQQQRHKGSSSAWRGKGRGRGNWRGHGKRASEQTREKQQAQSMGPIKEYNEGLKELDGDLDQMSASNSSGWSQARSVTPLFEEISMSRSASNEDVDEDANSMPDLEPLSDSLDMDVISLGSDSEEEIISEGWNDGGYYSADDEPGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FPP6</accession>
    <name>A0A8H5FPP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_010437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FPP6"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5345010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="545" mass="60773" checksum="BCE3561117CDA3D1" modified="2022-01-19" version="1">MGSANEGSSAKIPSGKKPYFGLTGNALNFWVSFACTTAMTLFGYDQGVFGGIIITQNFLETMGNPDAGLQGTIVSLYDIGCFFGAIATLVFGERFGRRKTFIVGKHYSHVNWSRIADDSIFSSPNDRREINNRVNTATAPVWSSETSKASMRGKLIVFSMIMNIAGFSLSNWMTYGFSFLQGSISWRFPIAFQLFFSVLLICTVPWLPESPRWLLAHGYEEEGVAVLVALEGGSTTAKDPMIVNQKLEILEAVRIEQETSLSWLDVIRGRTGDTGMVQRLLLGAGTQWMQQLVGINVTSYYLPLVLQNSVGLSNTLSRLLAACNSVSYLVFSFAGLVLIERAGRRKLMMYGALGQSLCYICISSLLAQASDGSERAAKFGAGATAFFFLYYVFFGICWQGVPWLYPVEINSLAMRTKGAALATGSNWISNYIVVQITPSGIENLGWRFYIIWIVFNAAFVPLIWMFYPETANRHLEDIDKLYREHKSMIFVSRIEEAIQTERPQRFVDADRERAALALENSGRQSRSLNKVDNKDVDEVEDVEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ75</accession>
    <name>A0A8H5FQ75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ75"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034187617" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="69098" checksum="8A7FAC6B6CA63BCA" modified="2022-01-19" version="1">MVRIAFTVAAFGLTCAYARISSVSRTVIINDSPYYLPTEPLVTLGQDTHNITGDALPFTILADVGDGSGVKSSVENWETIDDVFNKEFLNTVVLAGSSLDASGDLMSFLNESGTQMMLTTTDMSSVFSASTFSQLTDADLPAGPYILAHDATGSLAVYAPLRLHYDHSQFLQVYGHEIRWIYEVVSASLDTDSSPYIAVPSRVHTLSKNDSELPLAGLRVSVKDLYYMKGLVTSAGNRAFYSTYPARNSTGPAITRLTDLGAHMVGTTKMVQFANGDRATADWVDYHAPFSPRGDGYLEPSGSSTGAGTSIATLDWLDVSLGSDTGGSVRSPAALNGVYGIRPSVGAISLDEVLPLSPILDTAGYLTRSPKLFSSFGKAWYGESFQSYPAFPKKLLVSDDFLSVTDAANAVYRPWIEKLRSFLGGETAGNYSIEGHWNASSGIQAELGVYLNETYATLVAYYQWTNVGKPLFEDYAAQNGGRSPHINPQVRYRWRYGESKGADGYAAELEKRETFENWTLSNFLTDNAESCTESIFLYPINSGTYSSRETYYSSPFIIPFGFSSNRVANLARSAEVVIPIGQIPFHSNITEVEEHLPVSISLVARRGCDFVLLDLVDKLADEGLVQEVKTGRTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQF0</accession>
    <name>A0A8H5FQF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQF0"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="493" mass="55445" checksum="A3F5633D9ED27327" modified="2022-01-19" version="1">MTERRSASADPKLRCANRPHVFHPASNQDACYISENGDNPWVPCKAQPCLNRYNTQRLTDVELPNWLHVITQLQELAIQKAHRKPRTRSGQGTSTPTNQPSNNPPEPNDPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSEPNDSVMADTPPIGSNGTSEQGRKPDPFNGERSEAKRWLAQFNNYLRMNKGRYPTEESQVSLFLSFFTGEKGGDWATQRLTERDADEEDEELTDTPDQRRWITLKEIRDKFKRDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEESEFGEAALLEFYQDGLPPKLREAVGRTYPKWKNFDQYQERAVELHLEWLKERERQGRWKTTSTSKNSPGPSQGRTVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPSRIIRTAETASPPPVTVAQASSSRNTIKEISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRN8</accession>
    <name>A0A8H5FRN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000100">
        <property type="protein sequence ID" value="KAF5346649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRN8"/>
    <dbReference type="OrthoDB" id="3270652at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="323" mass="35505" checksum="FD5B63A02E839273" modified="2022-01-19" version="1">MTLPFSPTPDNTPAKQRHGRRTPIDTPFAYSMTLARLPDADDFLNRFMDDTIGQNELEEPPMGSALPEESIDHAPTGSLPTDGAPHRDPESHSLIHTPAQDALGVVTDQDVIRIITQARDMALRSRANTGDGAGNATEVKCEAEDDEGLLVSVKDVVEEEVEDMMDICSENDEQGRYDMMDIFSECDCSSSPAYPRMGCHCALMQFLLSVPTLILIFLSLCAHSDFCSSLFSILSPRPSLLLPTLALILKSVTQSQLTRAKDLVLDLLGWGVSPEYLIHIGVSSQTIYRVFTDLNLRLPRNLRLGSGRIVTVTMELGVKTEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSF9</accession>
    <name>A0A8H5FSF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSF9"/>
    <dbReference type="OrthoDB" id="2917041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="346" mass="39136" checksum="05CFA284E6F5418F" modified="2022-01-19" version="1">MVGKAQSQLRKAHDASQQKASQLESTLSRRARGGRTIQEFNASKQKLTEAEERIIADHIVKLGNRAQGPTELQIEEFANHILFNKYGEKYEKVGKRWLYDFYARHPEIDTYWSKSLDTQRAGALNEHVVEHWFVYVKTNVIDVGILPEDWYGMDENNCPRGNLAKERVAGGSRKKTQHQQGGANRENVIGIVTICGDGTVLWPTLIFKGANLWTAWCKNNIANATFSASLKGWTDLELTIDWLVNHFDPQTREKAQGHTRALFMDGHSSHFTEPVIQFALANGIVVIGYPPHCTHALQGLDVVCFAKLKAQLKKAVTEFEELSRLSIHSITTQVTQYEKTGYKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTM3</accession>
    <name>A0A8H5FTM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTM3"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="146"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5348342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="59566" checksum="31345E56F778293D" modified="2022-01-19" version="1">MCSNRNATAHSPDAQTANVLQVGSVIIAELESRIHEQEVSIASANSGQTIYLHDPYASYKASMTAKAQNVWGLKYEFSAQFGLPSRPGSALHSREPSVSAPSRPSSSQRLGDVPIQVRQTLLTTFLPYSADLGFFLDSSEFCNSVVSSSPTHPVTPALMYTVFLIACRLSGSAQISALEPELLSRAVASTAHVLSIATTSSGEHPGFKVLQAIQSHVLLAQYFFLTGRKLEGKYSVTLAVSLVLGTRMHRIRSEEESSQGQALHPSGYTGYSSGPGFPPPQTPKEESQRINAFWTVLALNSRWTAIEGTSTSLAYWVPAMRVDTPWPWVRLGSSTRSSSTIQKFLASAPDDGNSPMASHSKACILLEQAFELENRVAEGSTSGQQFLSVFNNLAALTARFITELPSIQSIQESTQSESGSPGNGSSKKRALLVIHTLARVALIKLYSLHEATNPSSSSERARAQQFQFEAAKEAAQMIAMVDLRRAAFVDPIMAMLWCIIAQVLSAQGVRGRGQLEIQSYVDLIMQAMSMLAPRSSLMSDQLVKLQGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FX95</accession>
    <name>A0A8H5FX95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FX95"/>
    <dbReference type="OrthoDB" id="2790258at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5353140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="734" mass="83421" checksum="C17EA82B521856A9" modified="2022-01-19" version="1">MVVCAKKNRPDWTQDAPPQIVGILWYLPTHTLFPPLIPACHHSRKGHRTANIWLVNCVQQNQGIFKNSDGRITRNIRRHLTGSEHHKKIYDEFVQEFKLKGWDSVDSTGEEFSPKVFMDLLLWWIVVDDQSINVVECLEFCDVLAYIGLNLAPGDIPHCMKLLELIFAQFESEFSNIKAELQVGRITLDNASNNNTMMRALEHMLQGTGVEFSAEGNQIRCFPHIINIAVKTSLSRLTYTELQGFDDADGVNPEDTVEFMPSSMSEEIPTDYLIALKVDLIAKVRKLVNACRASGKWCSTLQKTIIEICEADLKAKEEAGVKITEDDEENVIKVVVLLRDVDTRWSSVFLMIDHMLSLYPLPENEEICSLLLKNSEITVLNDIRLYLKTFHVIQEIVSSEKTPTLADVLPLYERLILNLKTLKIVLPKLSHMIDSSLGKIYEYVDKARSMHMYAFALFINPTSKLTWIEEQWNTEDISNAKTAILDVMTKHRTSIRHKKIRTKTPGQVTVDIGGSDAAWALQSGFDYLDQFTESLQTLSRTSSASLSLTSSNGSLSEIPEELEQVIDTSLGEEDCEIQAIAEDCQLAEAELRSWVSDGILKGSVDLIRFWDDKLRQRDFPSLFRLALDVLPAQASAVPCERVFSSSKETDTDKRFRMSTVLMEVLQILKHLYSDDRLDFCKSWVAKSSEMGEENNKKYCTETDGFRDGITTTDLEPDELREILMKGLHKTIFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3L9</accession>
    <name>A0A8H5G3L9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3L9"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42516" checksum="D4D49F8BD83535F4" modified="2022-01-19" version="1">MDISTELAPVEDTSLALSYDDSVPYEEQLPTPEQNALANRIGNTKVYLLSESSVARVAKRKRGGDEEPVEEEAVEDVDMNEDPSIRGNALLLTGSPVSHLPTSRIFAYATHFDAHPLGLEWVDDNTCVLVFESKAAAVTGLSCLSKSLEEEADLEGCVSAKAIPVALWPPEERINKSLGKGEGLKGALRIRWATHDDVKKKGAKRESEFYRKHGKMAGKETVNGRDLPNTMKKRKVDGDWNLARTRESLDEDLDRIREAADELVDESEEPASPPSKMRSDYIAADGRSLLERTSEIRLHTVEEADLASRITAPLPRRARRTATNLEDRLWSDQKVDHEEFGRRTGRNSRNGSGRSSRAGRDRPRKTRQELDDELDAFLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5C8</accession>
    <name>A0A8H5G5C8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5C8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5358646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="15937" checksum="A4F52A89DAC944CD" modified="2022-01-19" version="1">MVMDSALALRATSVVTGSFSIPDLPSYFKYSLRKNSYERQVLFETKGWFFQGDFFVKPRASDSYDRDNFAFLASTCYPEADYLRIRACSDFLILLFHLDDITDDMDTTDTDSVAEIVMNTLRDPYGYDSPTRVGVLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Z8</accession>
    <name>A0A8H5G7Z8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000046">
        <property type="protein sequence ID" value="KAF5359926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Z8"/>
    <dbReference type="OrthoDB" id="2408877at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="633"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5359926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="720" mass="79980" checksum="5BE2044F3BC4EFE2" modified="2022-01-19" version="1">MTMALESAQQVDSATMQMFMANPQFMNMLWSQLQSMQQQNQSTQSGLMSSFAAVGANNPHDNFSSDSECIQETPATSNNNNDQTCLHSLSGDTQTTNDDGGLEPEPMSDIRSDVALPQVASRSVAIPNATPARQRPLRRVNANGLKPTPARPSFREPTEKENEVSSPGSLKLTLTDGVSLPLQDDAPDDTVEVVAESDNTEPKTKKVKVKDAMKLLTTACQNVVEIANICFRHLMMQRTLWLKDKTEQADAMALDAWKLAVKFLIENCEYQDEPLPTLTELNIRGGSKFDNPGSVLQLVPETRNDTNRRSNFDRQFSATKRLYKHATPASNTSTVSTSSDSDTTTTSSASTSQNSLISQSSSEASSTSSSPGSDNRGSESDSDYVGSDFFQQVLEDVELDIIVREVSLMASSAALEVELTVGFDSESGMMGSDADDEESEEEDMDLDDWDMDMATGGARSDRNRTRQVWLCVQQELSAMYAHRYTIPCKIHVKAPPQLPFILTHSKLHQLKDFRQCLRVSPYTFDHLVERIQNDTIFTNHSSNGQMPVADQLAIALYRFGHYGNAAGLDAVRRWAGIGKGTVVLVTKRILAALLQSDMLAENLCMPTEEEREEAKAWVERCSCPAWRNGWCLVDGTLVPLFNRPYWYSESYFDRKCNYSLNFQIISLPNLCIINVGYGYTGSTHDATAWEMTRIKQLIATLIRCGEWVWADSAYPVHPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G851</accession>
    <name>A0A8H5G851_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G851"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034954485" description="Glyoxal oxidase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="69"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="451"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5360000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="71609" checksum="CB4358A6EE80B201" modified="2022-01-19" version="1">MRVSSPSYVSFILAALSGIAQVSGAFVEGDWVLTQDGTTGVSALQLAVTTETKIIILDKAEHNPLLTSNGTNAMAAELDLVTRQVRPLNGARSNVWCAGGGFLSNGTFINSGGNPSILSSSNGLQAIRQFEPCDDESCDIFDDSGARLRVTSPRWYPGVVRIEDGSLLLMGGSVLNNFINVIDINNPTYEYYPPKNINGFNGVQIPLKFLNDTMNANLFPYMAYLPNGKIFVAANTQTMIFDWKTNTERRLPDIPNGVRISYPYSGSAALLPLTPENNYTPEILICGGSNISDTLDGGLISSQSPASKQCSRMVLTEEGIAGGWKIEEMPIARTMGEMFILPDGRLILVNGAQTGFSGYANAADPVGDSNADHPSFTPVVYNPDAPEGSRFSSEGIPSSNIARLYHSTATLTANGTIFIAGSNPHEDICFDQYPTEYRAEYLDPPYMFQPRPNFTGLPSTIGYNQTFSLNLTMPSQVGNSSNGDNVTVVLMDLGYSTHGVHQSSRYVKLVSSVSQDGKTITVTGPPTPQIYPPGPGYLYVVTNEGVPSPGKKLLVGDGQSPPADEAARENMLDRTPSANVTFSQVRVAPTCKVSGGGETVTGSFPPTAITGSQTSVPTVTNSASGSPVTAPTVTSTSSMIPSSGSTFDSLKPTSSAPTPVSSLSESKGIQPSSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAQ1</accession>
    <name>A0A8H5GAQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAQ1"/>
    <dbReference type="OrthoDB" id="2860144at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034323380" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="209" mass="22226" checksum="FE69E1704CAFF881" modified="2022-01-19" version="1">MRCSSIFALVALAAATSAATISTVDKRKNVDRPDPANLDHCPSHATGDADTCTFESESQGADAVLEHIVGSPVDNCKGGTDDIKTTIGGDTSVAQTWKYGISAGFSADGGEELPVGVSFESSDTWSNTDAKTFRQNIDVTIQPGKKAALVAKVTHKTFFGRVRLNYGDPSGEPGANDYHYVWYANGVGSVQPTDQVTYDQRIVNCDQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GCQ5</accession>
    <name>A0A8H5GCQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GCQ5"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="155" mass="17690" checksum="EBA0BC7CE45B511F" modified="2022-01-19" version="1">MMTQLSSPIAEPPKVSVDRYRGAVVEDLQLPPAFALPFTEHVSRVIELAFEREFSHIPILDKHRKPLGYVEVASLKEKWEAGQMDPNDKVEKYLTKFKRSSSEPYTLITPLTPLSELEEFLKSNIFALVTDYERKFVLAVATSDDIKEFAKRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD69</accession>
    <name>A0A8H5GD69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD69"/>
    <dbReference type="OrthoDB" id="3359616at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="16786" checksum="9FE10915023451EA" modified="2022-01-19" version="1">MSTGLQNLTFGDGSSLLQYVGVWQAGTWGDNGTLHLTNEPFATVTLTFPVPANAFYFYGMKRSDGAKYVACIDESPCDPANPNSLPIDAFDPLANNFSNDPPVLLFSHEFDDFAVHEVTIMNLEDPRNPNHENSVVEVGSFEIQVQATEAAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDE1</accession>
    <name>A0A8H5GDE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDE1"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034083157" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21108" checksum="445689CD85C37017" modified="2022-01-19" version="1">MRFSVYLNAVIPLLTFVHGQDTCLKEVKSAFEAANIPEDISITFDPTVLLEVTLPQTSGDSITLHAGVQVPREDTAGPPTFSIDPSTAAAAGPGPFVIAAVDPDAPPTVAQIRHFLGSDFTVNGGPLTNSTPAISPFRQPSPPAGSGAHRYTFLLFNQPVNFDEQTVVTSNTSVQLFNISAFAAATGLGSPIGGTFMLVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDK7</accession>
    <name>A0A8H5GDK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDK7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="183" mass="20225" checksum="BB3131A23D104A9F" modified="2022-01-19" version="1">MFIATLFLNSLALAAICLHFLWAQILSRNLRQRTGHLLLCYSETGRTAYRVHLRAQKIRDSRPLSAVRYTLDPSAFHARWILGCYKIFLDEKSDDAAKLYHLIHTGQLKIGNNDQRAAVAVDCTLVLEVLLHELPTPSVHASRPAGNAITPPSEVLVPEPTTTVQMPISCSSPSGASLSDIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDL6</accession>
    <name>A0A8H5GDL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDL6"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="190"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5362850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="861" mass="94050" checksum="A9DE3B0A6E22B9FE" modified="2022-01-19" version="1">MAQSYFPAQVTSPVKELASFAGERQLKVEDVQEAYIEQKDKLIDAIDSTKSILNNIRIFNRDEWVVRYPQFNEPTRPETTKRPSGRRSLTFVDDPQNETEVVLKRDLSHSVSLSTVVDDNTIPAEQEEETLLPSSDFHVLRLDLKLGVNGSATSAASLVSQLEKASIANLLDERIATSLSHVDKLRLRVEDTSSKVLVTGDLNAGKSTFVNALLRREVMPVDQQPCTTAFCEVHDAAENNGVEEVHIINDGATYDIKDEATYTRAELSTLEDVVGENESSQRMLKIYLADSRTPSESLLNNGVVDISLIDAPGLNRDSLKTTAVFARQEEIDVVVFVVSSENHFTLSARDFLANASKEKAYLFIVVNKFDQIKNKEKCKRLVLQQIKELSPRTHDDAEDLVHFVDSASALQPFAANPAFDDLESSLRSFVLVKRSKSKLQPVSTYLNNLLCDIELLAGANSIVANAELQQAQADLSAVKPVLEKMKKGREALEDSLEAVEEEGVATSSSKTKSILLDALERVGHGKLGVDSASISMPSYPGLLRVWEYARDVRKALIASLDSAVKLAENEARVATSAGVDKIKNLAEEHLPEGVERNRRVFMPEAMFSTIRKNGKGTPKRRQSSHFTGANGIGNAVVAGGVVGLGIGLAQRPEMLETTFLDLFDVHHQLWVHFGDGSSSSSSSSKEDEEGSATALGLVSVGVGAMTMFGGQAIGAKGIIEGIIRVSDLFGNETARKWVAPVLGAVAIGSVAYIVLELPNSIPKTVGRRVRAAVVSGNGEGEEENVFVEGHVVRVGKETRKVLRLASWDLKTRFNGALEERAAEVKNKEESEKKAKRANEYFGEVGRKTRQIRVDAGLGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDQ4</accession>
    <name>A0A8H5GDQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDQ4"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034395930" evidence="2">
        <location>
            <begin position="20"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5363042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="560" mass="62649" checksum="87929517B208F25B" modified="2022-01-19" version="1">MEMKFSIWMILGLLRQVKSVNGTKEAMVLHLLKCPNALKKGKKVAWELKAGKGASNDNGTDGDDESSDTETSQPLKRKKLEVYTQTTLKYLKGPDIPFTEVQKEAIKSQFGCATASANLPFCWVDDPEVIALFMMFRSPEQCELAGWILNEEYKKVEEELKECQLILGDYFKENKEAAGYAEDASNLLGWILNHTKVHAIFDETQLEKNPALTKLCAYKTTNLTRWTTHFGSFDCLGDLKDPLQHAAFLKQQLVIDVQVGAEKNSQKKQEMTDSANAQCDLILNLAFWKSLRSIVDDIKPICYAVNICQSDKVCLDQVLLTLGGLFLHFSCHENHVVHEGMRKHLEKCWKSYDRMLGPFQFGPYWSTSRSSTNMSNPALHHLDSPKQNLLSSMPSKSKKKIMCLRLLLSIWPVLGIFVTGKKIKVQSKPPLSKDHQDLAAQLTQAVTSPENDKGPSQISLPAGESLLAIPQYKTLTDDSVEAGENTPGTGSVYVASCAGWQDEVEDLEIEMEIDDLTDGGPNSQLSWPINHRWLPITLKKLFGGTPTQPLDDFMGVQTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDS6</accession>
    <name>A0A8H5GDS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDS6"/>
    <dbReference type="OrthoDB" id="2751409at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="572" mass="64311" checksum="E3BEE5C40E7E70A4" modified="2022-01-19" version="1">MAVLGDLSAELIILILTHVPFRDVFSFQLTSRSFHTVISESTELQYHILLQTSGMLDNCNSSLPLRTRYEMLREREKSWLLLQPRFTRRISVGHSAVVPYELLGDVYMVSDGSKATISTFTLPSDAGDPVSSSRKLHVGDFDQGRIIDFAVAPEQDLLVLVTSDSDTPTGALNLQIHCIQRTTYKRHPLSVAGPISLSFDVPCSCAHAAVAGDLIALTFQSGDSEDDQVFLLNWKRSTVLAEMKSPTHLHGNAIFISRDILLVPNYTGLSYTGPSIQLWRIPEPSTKRVVLTTPNLTLNLPAYHPEVEVHEFLCRNSDNSSSQRPFYSDPDQSIVLFQLFTLSEPEPSSIELVFFVHRKVFLELLSAHENQPSSDSVVDHNSMHVLPWLSWGPPNTRFFHPTWYDQSSHTDWIVTAYGQRYVFLDLRYRTQEGTPVVVFDFNENTVKRVRNALEKAQTQDPPSLDIALLDVSIPTSIKGPESDGDPALARQRIGWCWKNRPGEDSGRNVPWGDQVLSQIFSEHVDGDLPYVMLCSEKLYDFTGTMMDDERVLGARSGEFHAGVDNLEVLWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGK2</accession>
    <name>A0A8H5GGK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGK2"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="16743" checksum="9E6E2DECBC92BA13" modified="2022-01-19" version="1">MSSPPPNEGQSPAPSRSPSAGPPPARQQQRSRTRTRNRSASATPSEVSEDAAPSRGQRGPRRRGGNRQSQSEYDNLMRGGQVAQRRRGSALQTQAEEPEQPPAQQPQQPQQPGKGGDDEDMGDKPLKLRLDLNLDVAVELKARVHGDLTLSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGR0</accession>
    <name>A0A8H5GGR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGR0"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="64"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="404" mass="43180" checksum="42C9A207DD5B0285" modified="2022-01-19" version="1">MEVGKEPVINRADCLFLAIRDDIAYSTSLISTIPTIPMQKSPQSTKAIVVRKSETPKGPQLYHGAVLESRPLPTLKPGEVLVKMGAVAFNHRDVWIRKGLYPNIGFGYVFGADGAGTVIAAGDSKDPLLNTRVFLSPQHGWDNHPDAPESPTFGVIGGVKFPAVGTFAEYVVVARDKVIPSPSHLDDVKTAAWPLAGVTAWRATMINAAVEAGHNVLITGIGGGVALVALQLCVAKGANVYVTSGSQEKIAKAVKLGAKGGANYKDKKWSKQIQDLLQKNSPSNPQLDSVIESAGGDVMNNLGLILKQGGRVSCYGMHANPSIPFTMRQVMRNQKLLGSTMGSIQDLKDATDFLYKHRIVPVVSHVIDGLESAEEGFELLKNGEQFGKVVIRIDNNGAGVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH75</accession>
    <name>A0A8H5GH75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH75"/>
    <dbReference type="OrthoDB" id="3068835at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="284" mass="32654" checksum="7B2BECF08784D3E4" modified="2022-01-19" version="1">MPLLISEPTGENGLDTEKKSSLKELWNKFGRRVGSLVLRSPIPIPWGRRIVRAITDKAPSIHFNEGETIEGSVLRRRLAMVQESGLALPLRLNDGLPPPVEAKGVMDKMKAWGVEADTWIEGRRERRNERRRRRLKRFEEGIDLQSSGGQVILGRWFKDDVKDPSFSRRETMSSSAAPKAFKFAGRAHNYMEKRRMEREIKEERKFLNHRRESGISSQSPLQKRVAEQDLLEHWATDEILWIVIMGTEKVSQIGGVDMAERVQDEEEQIGGNTLRQEMVQEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHJ7</accession>
    <name>A0A8H5GHJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHJ7"/>
    <dbReference type="OrthoDB" id="3248190at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="182" mass="20696" checksum="94C089D509B667A6" modified="2022-01-19" version="1">MVASFKTDFHSDIVVSSRLLWILLGTRAKQMCGRKSLKIREVSLSARKRYSAAARKMAIDRLSSCLLTALEKVVLGRQYQVHKWLRSGYVELVIQAFAITTEQADAVGHAVALSLLRRLREELRRKQNVKRKTAGSRGCVDTVCCYCGNEFSKADVEKAVDEEFKNELKEVLEEDDRLRNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHK5</accession>
    <name>A0A8H5GHK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHK5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="104" mass="11698" checksum="229B35AF9008FC62" modified="2022-01-19" version="1">MSYSEKKVQRSFRGLQQQTSSLPPNLKHPSTTSTEVEAPTKPLCHLISPLKTPDQPPPPQYASSDRRRQSAIVIVVNTTFPGRISIGYTFYKPVWYQSPPPHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI96</accession>
    <name>A0A8H5GI96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_005389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI96"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="136" mass="15767" checksum="52EA591E7A58F552" modified="2022-01-19" version="1">MVKVYKPGKVAIVLQGRQAGKKVVVIKQVDEGSKERPYPHAIVAGIERYPRKVTRRMGQKKLATRSKVKPFIKVVNYSHLFPTRYTFELDGLKGSVANDTFKEPSQREDAKKNIKKQLEEKYVQGKNKWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK95</accession>
    <name>A0A8H5GK95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK95"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034094075" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="177" mass="19863" checksum="C9035571969EC47E" modified="2022-01-19" version="1">MFLKTRLVSLTTCAAALLLLNQVSASDSEFDPSRYYKIQTAGYTLFRHGNITASKSAPQEFLEFTIRDSGSGYPDVYTIGYNSIRAAAPCSEGVVVSGFAYEPYAYTNKTTVKRISEGKYTIEQGYDGLIRCDDHDLYWSIEKGVSQDQLQGIPITLQRLDYSGDRFYQTFDITFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL73</accession>
    <name>A0A8H5GL73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL73"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="320" mass="35434" checksum="F06771BB95D2A303" modified="2022-01-19" version="1">MRASCLLALSSARTSAIVSRWRLRCLGKTRTEPIMTITEQVLNVGGLPVHVHSNSQSNHAKPVAILFFLHGRNGECGRLKDFIDSIYSQVHDKEQDLKHELVIVSFDHRNHGHRLVDEKANMGWNRDASKCNPRHAIDMYSIQSGTARDVSYLIDFLPAYLYPAGDRTIAQWGVAGISLGGHSTWLSLCQETRVKIGIPIVGCPDYLTLMTARAKKFGISLEGSEYLPDSLLDLIRRSDPAATAYREMDPSRNPFYGKKILVLSGGSDTLVPWTASEAFVENLVVGPEGLKKKMVQAGAGHEYTPEMLAEMARFLVADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMF2</accession>
    <name>A0A8H5GMF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_009912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMF2"/>
    <dbReference type="OrthoDB" id="3259181at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="817"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="906" mass="102701" checksum="8CE0BF31168E5B4C" modified="2022-01-19" version="1">MSRGLYHDLAASGPAGVTFGNMDNSQCAVNPDGTLKDASEIQFYNDPADTVPISGPGSGDGNIRPSRNKHTKMLEAVQADLTGDEVTTKAKKRKVRKGKKAKKGSDSSEGSDFEDDGESTDVSEDPVSDVPNEERAQVLNAKTFPPKQKKPVKKKRRIHKKSAAKTQTPSRAATVEEVEDEEASPRTASLSSAAFGSIKRTNPIYLFFEEVAVNAKGETGEKGDKHFRCLHGSHHVLTITKKMNSSLNADHHIAGLHNHLKSNFRNLYNFYETEMALSHNKRSTSQLVVPRLMPNFKPCWATRLRSARTVSRRLLLGNRLLLRQVARLIYFMLSADVEPWDQEKFEDLLIKWIVACDQPFAEVETQEFIDLLQYVHHSGGALHIPKKDAVRRKVLKGKVALSIDAWTSSNQYPFLAVVAHYIADDGVLEECLIDFRELEGAHSGENMAEAVWKTLETYGLLGKITIIMDNATNNDTMMQSLEERCCRKKIPFSAKASRMRCMPHTIHLAALKARIGAISSKTSEKLSARGGNYQDNFNIIPDKSMATDNVEDNETADYDDDEEDLENLKRDGITPAVTKLRKIVRDVRSSPQRHAAWLREIDEIYAEADQEKRTYKLLMLILDVITRWGSTHQMMRRGIQFRDAVDSYAHSCVELQDFCLSSEEWDTLIMVTSWLKEFRAATVQMSATHTPMLSRTLEIMQDLEHHVRDILANLPWTTLAHIRDALVAAHNKLILDPRVNRDVLEEDYKKDVTLDGHLKKSRNELRTYFETNYLSRPSTVATSSTIPIQDDIVYIDGSPQKKKTSRYHRRVDAPRDELTEFWKQPPQDSEKCDPIQWWQGQKATFPTLYRLALDIFSIPGSAVAVERMFSGGRDTISLRRASLHPDTIRMLMIAKNRLHLARRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNR0</accession>
    <name>A0A8H5GNR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNR0"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="312"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115763" checksum="40A93BAB0E72BD86" modified="2022-01-19" version="1">MSNQEEKDAIGALTGFSLQNILGDLSLPAGANLSNHLGISGIPSLSSSQIYSDRWDDAVGADQGEDWEDEIDKEMEAERAANTDVKEEQRSPAALKQKQKRVKVVKRLVERPKSVYERFPAFEKDKILDFSELFKGYTVRKSRLGKRPYTLELTYPRKREVPKGFLESVAGDAKRQVESQRVEEVMSSGSIEADFRLALGERENISMPLHDRSFDLVLLSNWEDQIIYEPETAGNGPIRPSLKDNNLTTPVNKALESGTWTQSIIWSSDAPFKDFTQLEFNHEDDVVPEERTTEQYRPRKRLRTEPVQKDKFNLSNDQFYEVSKDGRHRVRQTFGQLTVEHAYPAQKLQLPFYKTRLSKQEARSFHRPALQFPSNIELRFSKVRTAKKKKDKAGRKLGKGGNVGEGLHSTNDLSLRDTSNFVLWEYSEEHPPIIPNFGMGSILVNYYRKRNEKDEHIPKFDLGTPFVLEPQDESPFMKFGYVDPGQTVPALYNNLIRAPLFRQQAKHTDFLVVRSTVKGETKYYIREIKNLFVIGQTYPVTEVPGPHSRKITNTIKHRLQIIAFKLLRKSPGERLKISRLMKYFPDQNELQMRQRLKEFMEYHRRGPHQGFWRLKEHLTIPSDAEMLKMVNPEQVVLTESMQVGQRHLQDAGYSQTADSIDDDDQNLSIEQQLAPWITTKNFLFATQAKAMLRLHGEGDPTGRGEAFSFIRISMKDIFVKAGEDYEQKLAEAENRPKSAHRYNVAEQQLIYKSEIERIWKAQFASLSRKDEPALTAEDERRDKQQQMAIAAQMKQREATPMDGFSRASSADPGRDQSVDPEGRRVLRIKRLIDGEWQTEIIRDPAVIRAYVKNRQAIEEENTLTDSLAPTGDADKDRQELARMIKNQERRLHRKNAKIAKEGGTPLQLSRPMKSDTTRRCGHCGQMGHMKTNRKCPRWAEFNGGAPPSGSGPATSPTQPTTAGNFGFPTTASTSFGFPTAVSSPLATSPPITSGGDYETPVASTSTAPKIKLTLGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPY7</accession>
    <name>A0A8H5GPY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_002918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPY7"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034643655" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="345"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5368937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="821" mass="91069" checksum="99F9E2B7C41C4AF7" modified="2022-01-19" version="1">MRWTLWLALFATCLVHVYAAEEGVLQTHVDLTPFLNNKAAALEGTIASFDGHNGSYPAEYLPIGTLVDASITYKLPNFSDMSTLDNVNCSGQVIPVPVGRYHSFGWLGATDGFSSLNANFTAIYEDNSTETLGYVVAPWWTSNPSLGPITAPFFNWGLSNGTTYQNHNISRMFTFQHRLDNSKNLSGIQLANVTGSARFTGTLSIHVFAMTLVSSNSSESSGEPLLAVQDVRSTTKFRTQNDTQVQLIEVTLNNFAPNDAPISSWITSKQTIALHSASGTIHTVIPGEVNRLRGGDQVRVIVGIVTEEGIEAGTKLDDVQVVVNGSPLGEQLGIVAGIPDYFVGDESLKTHESPEWFDGAKFGLFVHWGIYSVPAWTVSGTQYAEWYWYWQHNPANASSAVWLHHKEVYGEDFLYDDFFPNFTASVFDVNAFVQFVADIGAKYYVITTKHHDGFALFDTGNSSNRNSLNYGPKRDLIGEILNATKATQPQLYSGLYFSLPEWFNPAYAKYGHADFSDGLYHPRSDDPSNPGYNILQRTGFAGGLAQNAYNSSAPLEPYTGYIEVDDYLEDIMKPQMETLFYKYETDILWCDVGGPTIAPEILPAWYNWAKANGRQVALNARCGTNYSDFDNPEYSVTSSLKTRKWESSEGSDPYSYGYNQNTSYENYRNTSYLVHSLVDIVSKNGNYLLDIGPTANGTIVPPSRDSLLGVGRWLNASGDAIYDTQYWFVTAEEGNLRFTTKQDAFYIISFLYPEDGVVRSTSPLPLKTGDKATFLGVNGISQELDWQWTADGVFELSVGEIEDELRMVGDAWAFKFVYHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ62</accession>
    <name>A0A8H5GQ62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ62"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5368860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7103" checksum="42C069F591B1E0D6" modified="2022-01-19" version="1">MVLFPEVQHRAQSELDRVVGRSRLPSFADMKHLPYIVAIINELLRWRPATPLAAPHAVMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ98</accession>
    <name>A0A8H5GQ98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ98"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="101"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5369044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="493" mass="53746" checksum="D216ED8789ABC564" modified="2022-01-19" version="1">MSSQSSSATVSPTQTILHYDGSPDYLGAVPDSCDIPEKPARPFASRADTGAVSLTATLRGDPENVELAKEKITDEVIASATTKIEAAQLAKSDSSRLEWFYLGALWWSWFLLGWNDGSLGPLLPRIQEVYNVGYTVVSLLFVTYFIGFISGAGGNIWLNAKLGFGKTMLIGTCFHVAAYSVQSCAPPFPVFVLSFILAGFGSSLQNAHGNGFVGSFRRNKASRIMLLHAMYGLGAFCSPFSATYFSGVRHWSFHYLISLGIAVPNIVIQALVFKLKRQEDLLREADQLDEQKIAENSSSTSNGEDSLYRRIFSMKAVHLMTIFSFMYIGVEVSVGSWIVTFIIRERNGGGFAGYVSSGFFGGFMLGRLILIKVNQWVGEYNVIYLYMLLSIVSEITIWFIPSIIENALAVSFIGLCLGPIFPIVVGHASAILPPELFTGAIGWTTGVGVAGSAALPFITGLLATNFGIQSLQPFMVSMMCAMVCIWMLVPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQK8</accession>
    <name>A0A8H5GQK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQK8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5368940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="329" mass="37869" checksum="A4E6EBB297F88A60" modified="2022-01-19" version="1">MLCVESGPRHGHGIRSCWTTALDRLHTAKAEKLSRTSSIRTAQATYLFAVFTSPRRICDVIYNTPGAVSLVVELLWVRSIEKDILNPGSDDITGQHVIWHFKASCSKDSNRYLKNAIQTLDSELGTKVLQSLNTHARKKLNLRKLHEVTISFYFLRKYSRKFRFLFLSLHAMNLAITLFRKLVLLPALSGDEAHSRKFRCAEYLMYLSYMVDERGHTAIIEMLRSRLLFAMMEAVPYIFLQSHSDPEHLANEVQKPYFRLLDGFGLQAIDPSVLKVLSKSISAIEKEGFDRPIEKAPESMKRRWAALKQKVQDLIGYKEIWKQPTEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GT18</accession>
    <name>A0A8H5GT18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GT18"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="481"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5370587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="605" mass="62308" checksum="1B971203B6F91878" modified="2022-01-19" version="1">MKRSAVHQLTKDGRDEEDDDSEGQVGFQKADDTILATRVIRGLPKRNSAASSSTSSSSSQPDQSSSKFGAFKGFNTGSSSTFTFTPPAATPSMSPSQDPPLVAPTASSTAKALSSFLSSPSQNSLAPASTQSSPDEIAAETYWKSLRGLNVAFISAVQQAMEGDPFVDLNDTFVETYQRHREVIQRQFDNASQTDSSSPAPLSRTPTQAALAMPTPPSSSSSFSGFTFSQKSTSGSSESQGTGFTPGLTNGASSKTTASPFNFASSTSTVSASTSSSFFNPSSSGTSSAFSFGKPATSMTSTSPSKDSESSTPGSKSDTAKSSGFSFGAPATSASPFGSASFGAPPSSSKPNPFGAPSVPSSFPSSTPSSSSTSTAPKPASPFGGFGTGPASAFGAKTPTSPGGGSIGNPVGFGFGAAANNNKDKDSSNNATGSVLAFGSPAPKPLEEQHTAEIKAGGEGEEKKEGGLEAAALFGNSPHDEEGEGEEDEETTHSIRLKAFRLKKADEGAAGWAELGTGLLRLKKHKQTGARRVLLRNSSTGKVIINFNLYGGLNPSQTKKTVMFVGHEGETSQTYNVRMKTEEQAAELKNALEREITFVKAKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUP2</accession>
    <name>A0A8H5GUP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUP2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="241" mass="26188" checksum="6D0ECA620A6F0425" modified="2022-01-19" version="1">MSPSSSSSTDTPLLNVKPSGLASGPVVFTNPFANVYQPAGAKIDPFLERKRISTEQNHWSQAEINHEIGVRMRIKTVVDLGDVEDVLQALEVSVADGVVDVNEAKSVLVDLRQSLSDTLERERRGDVDVLKRKFLQKDLPPSNAGQVDSSTSSSSSTHSSSNTSSEEERIHELPPDDCSISNLSFTDADASPKSIRSSPFQVDLCLNANGKTTSSSSKPQSWTVMIRAARKIFNRFAPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVW8</accession>
    <name>A0A8H5GVW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVW8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="319" mass="35325" checksum="BD1541ACC2CABEF5" modified="2022-01-19" version="1">MTQGYAAELGGSEEDAEDAEDATKTKGGVTLKSDGAYVLKPDRLSEKVAENLNGLRHPPHPPNLSDQPPTLPLIFSEHTQESLEAWYIDANGKKKIESFPDFMTRFLTSLCADNVKPLDIKPSKAKQHSPKNDGTDNGSDAESSSEDNAASSSPLPSIDEETAESIVTATMSMALWHSPDATTAVSKMLRKSFTQLFTQALFVFHSFPDKESVRIKFYCGWYLIVLLFNRPPSILFSYEDLDKDGKLSAEKLVKLFPHEVILDGVRAAAGFQPTFIVPLVNMFTFNAQGKITGFEEAYLDTFREIIVEVAPNRAPTEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX01</accession>
    <name>A0A8H5GX01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX01"/>
    <dbReference type="OrthoDB" id="3161836at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="194" mass="21617" checksum="D470AFA31434CC49" modified="2022-01-19" version="1">MSLYQLIVVIPYNIILDNLYGIVFLKEPQITKLENVGQPAGEDVILAAGMVVMVLKNGMTEYKGTRKMISRIIFLTANTGFWTAAVALTEVVLIGAYSGGLQFTVMEMPLCNIYVNAFLANLNARRYVRGECYTEWQSSPSRIIGPRPVGTRNSFENSRPSGEHLESTVAHPMVKIETIKTTDYSDLTTKYPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXI1</accession>
    <name>A0A8H5GXI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXI1"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21051" checksum="CC4EF1A635E9B861" modified="2022-01-19" version="1">MPASPAVPGLFLCFAATVLLIFVCVSSPTWEHISFLNVGRGANEVHYGVFGFTGSGTHIGYEFVNPSQLGFDDSRINTKIIENLTKTLILHPIAAGLAGLAVLFGLCGVGYHRAGTVIMTLLAALATIITFIAFVLDMVLFGIARNRFRDQGTQAEYGNANWLTLGALVALLLGTCASGCGIFGRYRRNRTATGTAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXL4</accession>
    <name>A0A8H5GXL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="582"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1517" mass="168863" checksum="D875C36CEE9D0101" modified="2022-01-19" version="1">MNEPNPPLTTRRTVSPKHVLSSEILSVTSTMRKNSRWAASTHFINTGTLALGTDLGLRITTPTPRSQRNGRENREADLMAGFYELKRIVRDVDDVMTIPLTILLSPFFAIIRSPLSTGPITSAALSALHNFFVCGLVNAHSTELVPALVELSSTVSRCKFEPSDSSGDEVVLLKIMTVIQDCLCDHNVGSLLGDVEVCEMLETVLTTCCQMRLSEILRRSAENTMHKLVRTVFSRLHTLDPEAEEAKLAEEDDVEGEVKMSVSTGGPIDTTVPSVLEEDAANVEAETELELEKHEEHKEPPEEPSTASTPHSEYGLPSILELLRVIVNVLDPNDQQHTDSTRLVALGVLNSAFEEAGPRIGKFPSLEALILDPGCKYLFQLARSDNMLVLHASLRAISTMFDTMREHLKLQQELFLAFTIDRLAPPVPSAIAKSSTLGRRGGLASPRPGTPSGSPALGLPEEDKDSEKGTSTPTRVLVTPARGETRDLILETLSQISRHPSFMVDLYANYDCDINCENLFERLIDFMTKAVYSSNYTGALDAQQRNAQFLCLDMLLVFVNDMAKRAEGSYPEWPAEYPPAESLMQTKSQKKLILTGAARFNTKPKTGIAFLEENGLIYHDLSPVVSKAQSLASFLKGCSRLDKRLLGDFISRPENLEVLKAFIELFDFKDKPMGDAMRELLESFRLPGEAQQIARITETFANVYFDAKPAGIKSSDAVYVLAYSIIMLNTDLHNPQIRKRMSFEEYQRNLRGVNDGSDFAPEYLQNIYDSIRKREIVMPEEHTGQLGFEYAWKELLARSRQAGRLMICNTAVFDVDMFKAVWKPVISAIAYAFMSFDDEHIIQRAIAGFRQCATLAGHFRLPDVFDYVVVSLSHATSLLPETLQVSVPNYPTIDVEGQSVTVSNLSVKFGTNFKGQLAAVVLFNIVNGNGNALREGWTQIFEMFQNLFLHSLLPTRMLQMEDFLGGVSMIPLRGAQPQRPATRTDGGLLSALSSYLMTPYGASTETLPEATDVDIENTLCTIDCITSCRLDELYSQIMQLELDALVATVRALEALAHERTVAKLKQGSDDGLNPSQEEPSHALPYDPASVFLLETIVSISCQTPQHIEELWPIVFEHLSALLSSATQYSVLLIERAVVGLLRLCQILAQKPAPRDQIYLSLDLLSDLPTTIMNSVAEQIIAGVILLVQKHRDIIRSQTEWNLVFALVRFTLSHPEAARQSFDLVSSLVVDGPEQLVTGDNFAGLVTLLDDFATNASISIESQQRQGRRRESAKAASSPVVERGQRAVDLIVNLKKFISIITDSSHLQRVQAWRQLFLPLLISLGRQSTNASREVRHAAISQLQRTLLAPHPVLDEADPPQVEEIFNRVVFPLIDDLLKPQTSERDPQGMSETRLRASALLCKTFMHFQVRESQAEADIRILWIEILDLLDRLMHSHKGDQLYEAVPESLKNVLLVMNDAKILVPPVTPDDRNERQRTLWSATSERMERFLPGFLTEIISIPPPTEVPREKEGGLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXS5</accession>
    <name>A0A8H5GXS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXS5"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5373113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19937" checksum="23C6C52EA76737C9" modified="2022-01-19" version="1">MNRQEIVKIRRIHSKMDLTQYTIKAGHSRAKKPTNSLPHLSSSIQLSLIMPMIRLSTNIKLIDYSLTDPNLQEWAKNFSKFSATTLEYPEEVISVLVTQNETLTFKGTFDPAFLLTVSSPTSNPENNLKWSAAYFDHMKQTLGIADDRGFISFESPGKPYIGYKSTTLEELFKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYD9</accession>
    <name>A0A8H5GYD9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYD9"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55004" checksum="D0A748FEBEC6DE40" modified="2022-01-19" version="1">MSTLATPTSSPYRKSSALISTPPYIKASPSRLQSLYSDFSKQKQSNIASYQANIEWWRKSLESYVFSGLHGLDRLVLHAEKTLIENYRVERVGKPIGLGAVVADLVTPSSSSSFPALYPIAMFLAFPNSIYSAKSKLSYLSTLPTLFLSYAVAKPLWWALEQVGVVGEDSFTSSISSVFTSSSGTSKADTTWHGDYVFLSLLERVGEAVIEKQRAKAINASDALYTFEGFKRDFSDCFGPAEDAAAVPSTLISDLDTKVLLKYLERDKEVVVMDSGIVKFVDHVSSTEQAREITAVDRGILELKSAVEGLHAQIDGIQQKIDHCTSKASEALRQKRKNFAMSFLKSRKQLEELLGKRLGALENLESTLICVEAATGDIETLKSYDTSATTLRAILSHPSLQRDSIEKTMEAMAEANADAKEIDEAVRIGGDIAVGVEDNMDDTEIEAELSALIKEAEESAKDKKEQDDLEDLRSRIAELQVPSDVEQGEAGQAKVREAVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ07</accession>
    <name>A0A8H5GZ07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_000795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ07"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="330"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5373891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="578" mass="62365" checksum="71DA2F467D089FD3" modified="2022-01-19" version="1">MSLRRISRIFSTKPNSSTKSNGNTSANASSATATATATAAPKEKKSGEFVGSLDCGTTSVRFIIFDQHANIVAQSQLEFPQYYPNPGWHDHDALEIQQHSERCISDAVKELEAAGWTKESIKVIGITNQRETTVAWSRKTGQPLCKAIVWTDSRTKNTVAHFEKKLEETGIEVSPGEWKKGKDGVEALRQITGLPLSTYFSAVKLRWMIDHYPDVAAAHDADDLLFGTVESWVLYNLVGGVSKNLHVCEVTNASRTLLLNTTTLQWEQSLLDFFGLRKSILPKLVSSSEVYGNVAEGVANGALANVPIGGLIGDQQGALVGNKCLNQGEAKCTFGTGAFLLFNTGGEIVKSTHGLLSTIAFQLGPDAKPVYALEGAISVAGSAIKWLRDSMNIISTAAEVNDLAAKEKDTGGVYFVTAFSGLLAPYWDTGAAGLLIGVSQYTNPSHIARATLEANAFQTRAIIESMKLDSGTDLQHLKVDGGMTNGNLVMEILADIGGFSVVRPEMRESTALGSALLAGAAIKLFGWDLTKPETMAEVNTKGSKEFVPSLKEEDRQKKWEGWQRAVERSKGWEAGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ19</accession>
    <name>A0A8H5GZ19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ19"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="515"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70073" checksum="4950DAFAF09A8C7F" modified="2022-01-19" version="1">MFLSDSVTWVNRDPMIYTPDALDDPRKMVSTKRAVRIANCSGAVGDGYHQIYRQATEGPVDAIFGDYLSEMNIAWRALEMKDNSALGYEPFFLTQLQYKNTLEIVARKGIKLITDAGAFNPYGLYRETKKLLEEKGLSDVKMAWVEGDNVGQEVVAHAKDVGRFPHLDIPDEDLSKVKTEILSANAYIGVGGVIAALEAGAQIIICGRICDATAVMAVCSWWHGWSEIEYDKLAHTLVAGHIIECGAYATGGNFCGFQSFNLIDPGFPIAEVSADGTFVVTMHEGCTGAVTVDTVTAQLVYEIQGPIYLNPDVSANLEEIRLKDVGRNRVHVSGVKGSPPPPTMKLAVQTFGGYQGELSFYATGIDVEAKYTSMKEKILGTLDKSRFIKIAIDKYGTPEPNPRSLKTASVQIRLFLQASTPEPILELQKYTCWWFMSDFGGCFLNMDTRTLIPKPFTTFFPGKIEQGAVHVRAHIGDHVVEVSSVSKTAPFHGQKSYGPKAVTALSSFGPTRKAPLGSIVLARSGDKGANSNIGMWVRHDDEWPWLQSFLTTEMFQKLLRDDWKLEYRVERFEMEHIRAVHFLCYGLLEEGTSSSSLLDSLGKAVGELLRAQVVEVPVKFLERPWVGSRQAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0E9</accession>
    <name>A0A8H5H0E9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0E9"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5374309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="65292" checksum="20609164E5C21727" modified="2022-01-19" version="1">MARKLRITNPRVLAILKKLEVPHKEEAVFELTPWINRDIVPLPPSRRTWGPWSFVGFWMVTGINISGWVSASSLLALGLNVWQSMLSVVIGNLIVGCAVALNGLPGGKWHIGFPVINRYVWGLYGSFFPLLMRIMLSFVWYGTQTWFGGQSTKVVIAAIWPSFLTMKNTLPESAHMETNDCIAVIVFWVASLPWLIIPPEYYRVPFRFGSFSITVTAFTLLAWCLAKEGGAGPLISNSSRFINVPEPKGSELGWKMMLGVTTQIGGICAGIMNQSDYTRFARKPGDQLVSQLICVPIVSSLTNFIGLLCTSCAAGFYPDEGLLWQPYNLLIAIQTHSGNGARAATFFAGCAFVVSQWGINISGNAVSGGIDLSGLFPKYINIRRGAFITACVGLAINPWQLVNTANTFITVLSSFSVFLGPATGLMCTDYVVIKRTKVRLSHLYHPSKDSIYWYTYGINFRAAIAWINGVWPLMPGFIARVNETTTGKGWTHAFDLSWLFGFFVSGTTYVILCRIWPVKHLGEVDEEDVYGTFGEVYSSGFMGDGGGEGGVCAAPPKDGSGSGSGSGGGQSDDGSKKVEVEVASDANGAVRDLDYKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H196</accession>
    <name>A0A8H5H196_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H196"/>
    <dbReference type="OrthoDB" id="2552042at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26935" checksum="33F071DF5AB1787C" modified="2022-01-19" version="1">MKPRDYCCCAIPVVNAGIYVTLIEQFVAALAAGILSMATPDIVGAATPSFAPWIFGIVCLVAAAIQVLGFIGVAREKPILFRRYVSLHVLALIAVFAIAAVWVIISASRHNTAKSNCMSDFYDPNDSSLESQADTLCTIFPWIDVGIMGALWVLLGIVHLYLYTVLSAYSTGQQADHAKYDALRDQTIPMNSRNDPWDSRMSTDLLDRGYAHGRHRSATSVSEVMSAPPVEPKDGFYSSTQTPHKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1V9</accession>
    <name>A0A8H5H1V9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1V9"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="157"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="542"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="634"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5375137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="855" mass="93907" checksum="7CE368C19A4B8547" modified="2022-01-19" version="1">MDPSPTPLFLPPSFPYPIKVVSIDASVSSEIKRGTRLLSYSFVYLSRSVGAQPETRFGTWDSAIEGTLRSWNIRVGDVISQRRAKDKAVGIVIEPCKHGMQLGGLCVLCGKDMTNTDYIGFSDTSRASIQMTHSANGPTVSLEEAQRIEKENAERLLKARKLSLIVDLDQTIVHATVDPTVGEWIAEGEAWEAKRAASNSEETEASSPGADDECNPNWEALKDVKKFKLGPETFGNVPRGKGKAVNKGVESDGLMYYIKPRPGWKEFLKEVSTKYEMHVYTMGTRAYAEEVCAAIDPDGSAFGGRLLSRDESGSLTQKSLQRLFPCDTSMVVIIDDRADVWEWSPNLIKVIPYDFFVGIGDINSSFLPKVEPLTASVPPSSTPSSKSTAEAPPDIQTPEGVERTQLEAKAMLTENSMVLEAQVESRPLAKKQEELQDSSSANSTTAEPPAAPAASAAAESSETEEKPKDEDKPTTPMTKTPRKALLKNDDLELERVFKLLSDVHKEFFDEYEAHSSHPASKNRQKKVTESNPWDVTRIIPRTRLEVFKGVNLLFSSVIPLDTKPETTEIWRMAVMFGAKCSTELSPEVTHVVAAKRGTVKVDQARKRGGVKIVWLAWFTDSVALWHRQDETPYLLDDPPTAGPSSSPSSVQQVSSDPDIDEDDEWELEGSGATGDHSLGSTTSFEASQINWDDINDEVEAAMMESDDEDDMSEVNVGGQAGAQSANVSEDEWTDESISSANNTPRKKRKRLRSLTPSEAGMNGGDNDALRSPLSKRKKLAADRSGYSKLKEAISAEDMHSEASSTKAQSEDGGSDGRATPTKMSNGDYNEEGDEDDEEEEEEDDFLTKELEEEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H203</accession>
    <name>A0A8H5H203_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H203"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="41854" checksum="F5A36D75C91F8B1B" modified="2022-01-19" version="1">MASALNMSLLFRRHSCLSSSIPRSLFKSKTPIILVARKYATHRGATNSSTLSSSLDTKHHASRPESIGPFPIGVTPSSYGTEPVKKWSELSTGGKIKRTTARTSNLAVIVFGAGLSAVLIYCLTSELFSKNSPTVLYSDACERIKRSPQVAKYLHGPLAFHTSPPSLERPRHRNHQVSSQVFLDSYGREHMIMNFYIQGREPGAHSEYSDSDSYVDAATKWMQEKSSYLSEMSYDEMVGWTKERSRHLWDKFHRSFKYLTGSPVPPSMSDPSLRSEEEHKDEKSSTWQWTGLFSSLRKSRGGSSDASPEFNGRIYTDGEVHADFIRNNDGYFVCRYLLVDIPNSRAKNPIRVFVDRAPGVRENEAVLRWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHJ4</accession>
    <name>A0A8H5LHJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_007462</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="JAACJM010000050">
        <property type="protein sequence ID" value="KAF5357666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHJ4"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="110"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5357666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="429" mass="48543" checksum="0EEF2DF30FD26973" modified="2022-01-19" version="1">MAESRIKTLDKHGQEITTIGFSRFGFDSEVPIEALRALYLRPHYVLTSDSESSLGDKAKDAEHAKFADGNNAAYQSKSIYHPDTNAISYTTLTRFPPVKLLAPSNRKRILVTGGAGFVGSHLVDRLMLLGHDVTVLDNFFTGSKTSVSHWVGHPNFEMVRHDVVEPFMIECDQIYHLACPASPPHYQYNAVKTVKTSFLGTLNMLGLAKRTKARFLITSTSEVYGDPEVHPQNEDYWGHVNPIGPRACYDEGKRVAETLTYGYMRQDGVEVRVARIFNTYGPRMNPFDGRVVSNFIMQALRGEDLTVYGDGKQTRSFQYIHDLIDGLICLMNSDESRPVNIGSSDEFTIGEFAELVREIVEKVQDEDGVKRSRRSEVVYKPIPTDDPQKRRADTTRAKETLKWQPRWTVRMGLEEMVRYYKAKLAEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIH5</accession>
    <name>A0A8H5LIH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2235 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIH5"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9437" checksum="2B37DD892BCE853B" modified="2022-01-19" version="1">MPTPIPLAPKDFHQRTVTGSSTAETLNGGHGSSSISDSPVSPLFEKQATRGMSMDTNGWGSDYGEDRACIPPMHPSRTLVLCFDGTGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJN8</accession>
    <name>A0A8H5LJN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJN8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="156" mass="16923" checksum="26D1AAEF0949B41E" modified="2022-01-19" version="1">MSCFVKFLRGLTSETSATNTPSCVVDAPLVWEALIPLQQFLTVLSTSYSALVVKSAAVDQLNNTPTYPPQTCTWTTLQDSSSPTSWTSGYPNSSLSIHPSDSARPRPSKTVLDDWTAGGLYPIYSRRLLNRIFAVIPVPDACAGQRFQPVDGLPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMI2</accession>
    <name>A0A8H5LMI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMI2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="88" mass="9698" checksum="0343A2282C78D06E" modified="2022-01-19" version="1">MVWSSQRSVVLRNEENLDDKDDSCDDPTDPDESEERGKDSAGLKSPAGGEVAPTEVGLGRVACVLCFEVVQMVIWNETGQGRRKEDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMW9</accession>
    <name>A0A8H5LMW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMW9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="117" mass="12959" checksum="270242EB16D04404" modified="2022-01-19" version="1">MIMSTSTGIVGKDKGDDWDGYEDGFEDNAWRPEWRLVPRAMLSHFGTPREEVVGMYSNKGKGKGKGEDEEREGEGERKRTGNTGTLEYTEPDGSLPSSGDDVDDICTLHPVFDLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LR94</accession>
    <name>A0A8H5LR94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LR94"/>
    <dbReference type="OrthoDB" id="3264508at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="61029" checksum="E6C653C046AC377E" modified="2022-01-19" version="1">MSDPVLPLDVLLEIVRLLHADNGALYNICLSSRLLHSAAAKCLYARIQVPSQVDYRKLWSARLPPSQGDYRKIRSARLPPYSSYVRYLEMENQSVTEEMMAAVEAFSNLSSIKIRFGFRYPPTPPYTSQSEHFSWSALLRKTLEHHPSLREIHLSNLKDAYSELIQLVKSETSGLQKLTIEDSTTQLNLGLLASVRPDTSDFTQTLNELHIIRFGAQYWRTYGFHWNTPLLSSLLPHLRYVKRLTLGPMSSDVDELPLLGQLPSLRELTIQYDDHSSNTTYNSKKHTPFRLQSLTVIQTLPSRTRLQNDKFCRWVIKLISSSSLLEHLYIDNFSLPDLYDGRLLGRFIHARKNANASYDALIDHLVEKHPNSLQTLHLGFGFIRKKTFILICKRLRYLREWTFAADENVLRIFTRHASGMEWLHNVQIELRNLDSAARRPPLGGGVDLEMTFSTRHVWPRTVTPLELMEGCSGLRVLQVDRDLYEKSVTLCHNDDEIRESEPMPHAHLHTEIKHKHFSGRLWYIPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS15</accession>
    <name>A0A8H5LS15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS15"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="30895" checksum="1B913ECF3E09162F" modified="2022-01-19" version="1">MSEQSLLDASLSESFSPPSLRRQSIPPAKPQSEGTEETPANPPDTLSASSDAHEKWKEEYEDQVKVWKSQSAEAREKAEKERARWESIRRSASLEGVHINPPPSSSASWDSISTTDPVLEGSPSPADARDLVTGETPKTQVVEHTTHSRQETGDDQKWEDLPSEVTSSLPSMSFPESNEDSSPDHRDHDHRRQPPLEQPTSVTLSVFDSSLSTKTRLKALCSALAINLLLPFVNGVMLGFGEIFAKDIVLGWLGRKPERPGSVSSSLGLRKSLSRRSRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTG0</accession>
    <name>A0A8H5LTG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription and mRNA export factor SUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SUS1</name>
        <name evidence="2" type="ORF">D9758_002623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTG0"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="97" mass="11463" checksum="B4F8150E2F6F9A64" modified="2022-01-19" version="1">MPVGAADVESFHKQIKRRAIENGDWERLRSSFLTKMAENGWLDEMMQKGKNVAQNMDNLRFEELRSSLSREVHKGIPLEIRREVLQSIRLYLDKQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTI0</accession>
    <name>A0A8H5LTI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_003026</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTI0"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="122"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="397"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="512"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="624"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5368978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="764" mass="85445" checksum="C6A0CADFEA483A58" modified="2022-01-19" version="1">MLNFEDVEERDGVRLSWNVWPSSRIEATRTVVPISALYTPLKIREDLPPVLYEPVACKPPCRAILNPYCQIDIRGKLWICPFCLTRNSFPPHYKDISNTNLPAELLPKYTTIEYTLARPAQVPPIFLFVVDTCLDDEDLKALRDALVVSLSLIPPYALVGLITYGTMTQVHEIGYAECSKSYVFRGGKEYQPKQIQDMLGLSSTNRAAPRPGQPVPPQTFGAARFLLPIQQCEFQLTGILESLQRDPWPVANDKRALRCTGVALSVAVGLLETTYPNTGARIMLFAGGPATEGPGMVVSNELKESIRSHHDIERDSAKHYKRAIKFYEGLAKRASNNGHAIDLFAGCLDQVGLLEMKSMPNSTNGVIVLSDSFATSIFKQSFLRIFNKDDQGHLQMGFNATFDVQTTKELKVSGLIGHAISAGKKSPCVGETEIGIGQTSAWKINVINPHTSTAVYFEVVTPAGQPLQPGSRGLIQFVTHYQHSSGQQRLRVTTIARNFAEAGSPTIAASFDQETAAVLMARVAVFKAEVDESPDVLRWVDRMLIRLCQKFADYRKEDPTSFRLTDNFSIYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNEEDVNNSLIMIQPTLMSYTFDTQPQPVLLDSVSVKPEVVLLLDTFFHILIWHGEVISQWRKQGYQDQEGYENFKELLENPVQDAQDLLVDRFPIPRYIVCDQGGSQARFLLSKLNPSTTHMSASMYGSTQAAGSGQAIFTDDVSLQVFMEYLKRLAVGAQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTL1</accession>
    <name>A0A8H5LTL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTL1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="293" mass="32547" checksum="4168F7F87FD3460E" modified="2022-01-19" version="1">MSTLPPASSMALTRVRPPLDARTGTGLICPHPSCRRPIIGRVVGAMGFKWHPACFKCSVCGELLEHVSSYEGILDDGHGHQKGGDPHALGIDREGKRRGMPYCHLCYHEAFAPQCYHCKTPIIEERFISLDDPALGKRTYHEQHFFCSECGDPFIETRGGVGGTGELSFSGDGSFQDGGGGEFASFTVYKGYPYCEPCHVRLRLPKCKKCGKALRDNVGAVEALGQKWCRGCFCCEGCGEPFARDQSRNGRDGYRNGYGYEEEEEDEVEANFYERNGKAWCERCFSVLIRNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU57</accession>
    <name>A0A8H5LU57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU57"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58254" checksum="987EC745F6EBD127" modified="2022-01-19" version="1">MAAAAKSKPANGSAAKPSSTSGTSTPVSVADKRDTSDATTSSAGRPDKKVYDAEQDRIKGEIDALQVKLSAVRDKISLATKSGSGNERRTTLKSELDGIRDKQSANKASRSKILEQVKVYQENISKKIKDLEAAKSKTSFRSVAEVDAHVRNLEKQIESGNMKLAEEKRALAEISTCKRNRRVVESFQADQDAIETDRRAVDELKKQLDDPELKAVSERFDKIKSELNDLKKEEDEAYANRSKLFEERDNLQGQINALYNEKRESAQKYREANDRYWTKVNEDRARRAERARAQRAAEEAQKKHEIAQRLRDEAEIPAYQAQIEDCQTLIDALSGKTTGDLTFKSAGLMEKVDIAGVAKLDIRKIEAPSDDGLVARKKKGDDEESYFVGGKGKGKGNKKSSAKANGSSNSDLNIPFSTLSALLSLSIPPPTSSADVPRVIENLKTKKAWFEGNQARTTAENIAKAEAEIKRLTGEAKEVEPPETTDPTPPNGGGERPGEPAPTPKVADAPAIAVPSEEVVEKLESVAESEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY92</accession>
    <name>A0A8H5LY92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY92"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5373943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="371" mass="40949" checksum="C31ABF6AD5743B94" modified="2022-01-19" version="1">MASDPQMIASQRVVEDLASRLRRRQVVGSRQSALETLLVLRQVVSRARFSNVEQLVELIRSVGRRLVDAQPKEHSVGNTVRKVLHHIREEYRTATEGTAPTPAVTFSIAKFVSQGQPRRHMAAPRSDATSVPLKENDPDDPDSFARTLKPVLMEAIQDVFDELETVYDNISKNAKDHIHSDEIILTLGKSRTVESFLKAAAHHRNYTVIVAETAPSYGGREMAKSLSSAGISTFLVPDSSIYALMSRVNKVILGAHAILANGGMFAISGSLLTATAARAYSTPVVVCAGQFKLTPLWNLYHEYGALDFGDPSAVLGFEEGDLVDKVDVVNPHYDYVQPELLATFITNYGDHPPSSIYRLLKETYDDEDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYC4</accession>
    <name>A0A8H5LYC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peroxidase</fullName>
            <ecNumber evidence="18">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D9758_000996</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="18"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYC4"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="6 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034825460" description="Peroxidase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="20">
        <location>
            <begin position="70"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="43"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="277"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF5373896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="394" mass="41583" checksum="08CBA6A570624016" modified="2022-01-19" version="1">MISKISPSLIITALLAVSVSARPAAKLRRATCPGGQTTANQACCVWFDVLDDIQKNLLENECGEEAHESLRLTFHDAIGFSNSKNAAGEFGGGGADGSIMAFTDQELQDPANDGTDDIIGNQRTIALNHNVSFGDFIQFTGAVAVSNCKAGPHLKFFAGRPNATQAAPDNSVPEPIDSVDDILARMADAGFSPEEVVALLASHSVAAQDTIDPDIHGSPFDSTPDTFDSQFYVETLLKGTLFPGPNGAHDGEVQSAIDGELRLQSDAALARDSRTACEWQSFISKAIASSSSPKAFKLHRLTPLLFSLSTADHQSMITKFENAMLKLSLLGHDQNDLIDCSDVIPAPDSASLPDATFPPQLGINDVEASCSETPFPTLSTQPGPATSIARVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BBK2</accession>
    <name>A0A8H5BBK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000414">
        <property type="protein sequence ID" value="KAF5320220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BBK2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5320220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="84" mass="9010" checksum="9ECDFDD9E6424E3E" modified="2022-01-19" version="1">MDTTAVGYIITHPFDIHYTSFSLSSSSLTGPGPTPYPDFNVTPPAPIPCLDTNNPHLPHPSCNVILTPAKYSIEGVLPTKAFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BRT2</accession>
    <name>A0A8H5BRT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000370">
        <property type="protein sequence ID" value="KAF5328044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BRT2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="212" mass="23480" checksum="0F94F79161AC1767" modified="2022-01-19" version="1">MSLPSDSNDPFTPRRLPLSPSKNTRSNTQHEHQHTPTPISFTYPPVPASTERENTAPVSVERSPKRQKITHAFGGVNVGTRTYEGPPAFFYEPTPREPRKPSHAYKLNVQTSTPPHIPNSPVFPQTPTAFNSFYSNFPSSPSTQATSRSPKSRRGRPKQKSSTLAGPAAPTPASPPAVEEQLEVLLFQFFQIRTLSVQIHPACLECLRQLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVC3</accession>
    <name>A0A8H5BVC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000339">
        <property type="protein sequence ID" value="KAF5329919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVC3"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5329919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23818" checksum="38EC8092DA7804E1" modified="2022-01-19" version="1">MSNLELLQIRQLAGHSESRYSGRSANALCRRRNDGLFLDRSRQHSTCSDCSVQEDIEKEMVDAGLIPPPQPALSTLPLKTENPRDSTVLISLNSRSGKNAAVDEEEEAIRTRLEAIGLHVGANFAERLCRDRSLFTETLDVIKFVCKDLWAACWDRQVDNLRTNHRLTKSIQGIYVLQDNAFKTITCLSSWEGRADATRKAKLGSNSVHDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXU7</accession>
    <name>A0A8H5BXU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Novel STAND NTPase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000328">
        <property type="protein sequence ID" value="KAF5331293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXU7"/>
    <dbReference type="OrthoDB" id="1534087at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049052">
        <property type="entry name" value="nSTAND1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20703">
        <property type="entry name" value="nSTAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 1" evidence="2">
        <location>
            <begin position="192"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5331293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="350" mass="38941" checksum="D1DDEE521FEA83F8" modified="2022-01-19" version="1">MVLGVQEWACIPVGLCDDGNRNRNGNSADAGVAGIGIETGRGWVIGALDPSIYLLGYPRLHFSMSKRIGNDPGGDSRYGRQEDANASKKDKSNKGRSRISAKFVRAFSSLQLGSKKEESERSRIQERAPTKEPSNPPEQGNTSTEWFREAHNFSINNSVINNHMIGVAQPQPTPQKRITHDDIHFETPPVPKVFTGRDPLVKEAVEILCRKGQNHLAILGPGGIGKTSLALVIGNNAKVQRKFRKLHFLPCDILEDVNDILQGFMQVLKIKPQEGKSDHDSLYDYLQTNKKAVLFILDNFETPWNHKDGHVKARSLIEKIGTFSCVTFILTMRGMDGPGDIPWHNHKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZR9</accession>
    <name>A0A8H5BZR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_017447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000311">
        <property type="protein sequence ID" value="KAF5332343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZR9"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5332343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="86" mass="9372" checksum="5714D5F3DB7286B2" modified="2022-01-19" version="1">MPCELSRAQEALATAQQTAKSSLLTPLRPFVLGMRPCGLAINREYWSGAVRSGEIARIGVYALEAYGIFKIGEIIGRRSLVGYNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0X7</accession>
    <name>A0A8H5C0X7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000295">
        <property type="protein sequence ID" value="KAF5332973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0X7"/>
    <dbReference type="OrthoDB" id="3018247at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034062326" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="130" mass="13539" checksum="722442E076F3DDC9" modified="2022-01-19" version="1">MVFSLSKVFVALVAVTAVSASAIKRQTDLASCDFVMTPDATVEVNDDLTTEFNFVLGRSLSIDAGDATIDGTGSTFVANDDGTFTVHDNLGVVGKSAQDTASILEGWPGETKEGIQANWLIDSVSCEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3I7</accession>
    <name>A0A8H5C3I7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000258">
        <property type="protein sequence ID" value="KAF5334560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3I7"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="474" mass="50554" checksum="0F7487F2037233F1" modified="2022-01-19" version="1">MTTLTQETDSSPAHPGPFPFDPGFDIQSVASLAVSLPSHSWEFGTASEALLELYNPELAVFGEDPFGLVPPLSKAQGLGSNRSQSNSNFPFKIIPSLTYASSKITLNLSSNAGANVLSDGDGATGDPASLGVSAVLLGRGLGFGFGQGGKNKTWIFEFREGARRTMEYLVGGAPRYANGAISQRADVAELWADFVYMAPPFLAYYAVSTSNLSLLLDTVDQCGFYRQILQLGSPSDVEDYPPSPTDALNGLWRHIIGPQSSDPGLWSTGNAWAAAGMTRILATVVKAPKELFQSPIRYPSTNISASSNSSSLVPSNLRRTTAISVLTTYIKEILDGVIFAAPLDNGLLRNYLNETLESGHGYGEISGSSLLASVVYRMIILRPDVFLDLPADSDSGKNWTTTGSAYLDWADGIRHTIGSEGYVSSNGTVAPAVNPLDWGSTVPYTAGSPEGQNFVVLMYAAWRDCVLEGLCQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9R8</accession>
    <name>A0A8H5C9R8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9R8"/>
    <dbReference type="OrthoDB" id="2679643at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="404" mass="44626" checksum="192B7B976F6D7A22" modified="2022-01-19" version="1">MSLSPLQLETIIVSLEATEIARRWAVAAFTLNVWDIIICLDKEIKYFWTGPWTISRALYFWTQSTNAGALSEPLPFPIIDDVSSIPIYQMSCERGIKACFAITVVGLATIQLVLVLRIWYLFPRSLFIRALCISSFVLSTILSAIFVGQSFSLVHSTKIDLSLLGLSPSPSASSPSLSPSPSSPFSSSLQEGLDLQGFAATLNPVITTGCAVPPPGNFWRMYIPSLVLHTLLFVLTTIRAWRTPNIFQEAPLMRRVLRDGGIFYFVVIAVVGIAAVCSFFTDKPKINVPAIYSGALFCFSSVAISRLMLSIQSVAAHLGYDEFWVLTNVELSRVAWRSHKGSHDGEIIVEVDGRIGSFDDLAYGREYDYEHGVDGIELTPTNVHREGRVQDTAKPRPLPRIDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBK5</accession>
    <name>A0A8H5CBK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBK5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="342" mass="38980" checksum="ACEBE2D76A2F01E1" modified="2022-01-19" version="1">MGSQTELLDLYDISLLLNYERITTEPLFRHARLREIAYPGQDFKTVYLPPASQFWKDDRRTGYLFDRPAHHTGKIDVNGPPDLPSNIIPDHLPKSDPLRSLTPKQLETAFWQGRAHDGCYKSVDLLQKFFAFFPPNTRLRIRHGLQGKKPGKEYITRVESRVILEVTLVNPKHTLLAMVQPEGQMHISGEAHTMQHAVLGFTEGGPDDDLMSVLDLSSMQFGDVGRGPGPRGQEPFALDTMDEFRARLEKVAEGKDDSRTKISHWMTPGKHERWLQLVAKKAKERWDRRESGRWCGHCGAPLTVLKSCSGCQNAWYCDADHQKLAWTFHKHYCKPLAPTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCY0</accession>
    <name>A0A8H5CCY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000184">
        <property type="protein sequence ID" value="KAF5339512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCY0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="317" mass="35455" checksum="BEA779D743B87B4A" modified="2022-01-19" version="1">MRWWFRGRWGNCTRLYHLNLLQRLQEQGSIKTGVLRTGIVFTCSPLPIPAFPSMLSRLHRRVLEPVIILSSCTFLFLVTTLTSPTLHPHLLHLHALCFLLPHLVPIPVPKSTTPSPPASQPLPKMGLVIDSGLRRLIWRRGRKFSGRARSGHSRTLGSACACWGVGGNMVPPEGVSGDTTTTATSVDPSQEVGRKKEDAEGQQERDVRDEDGKGWSRSRSRTGPRGIKNPILLLSLSPPPSSHRCFMPPSSSYSLSSSERHIHDLTDVDADDVFMDYSPSRSLSHHHHHHHHHPKHQNRPDSPFNPFNLDHYADADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD31</accession>
    <name>A0A8H5CD31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000184">
        <property type="protein sequence ID" value="KAF5339500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD31"/>
    <dbReference type="OrthoDB" id="2596754at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="512" mass="57305" checksum="8C8BAA6E23D249C0" modified="2022-01-19" version="1">MSSRNGSRTEPNENEHIHLLQKVNALLVYLQLPITLESLFELTPSLLLAVLECLLETRVPIEHETRRLLALASTSKKPTRDIDKATLAKIHAMKLFLGTLETDIVKADVGLSAVDPEKLAEGGWDEVVIVARVLGTLFEGLHELFDEEGPSISPKTATTTTARHLHQDWHAEDPNHLHLLSFAHTSLHLALLRLHRRVLEPFPNPASASAPYASTRSLHPLPSTPPRSRPHPHARSQEVNNSPTKSPFTPRLATHTQTQGEGGTCHQHQLWIKKVDLEEEVRRFSKRERSERSEGFEKSERSGSLSGHGHDHSGEEVDGEGEGEEGRNRRGSKSRSRSRARGVKNPILPLSFSLSSSSSSSKRKRVIHNHTDADDVFMDCDCDFSPSHHHHHHHHHRNGADFKPDFNPDSSFNLNLDHCASTDADAYNSGEGEGEDNDNDNVIGEVEDEEAEAEDGAEEGEEGWKDPEWEAEENHADPYAELDPHQQTILLLQERARLLEELARFRVRSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE82</accession>
    <name>A0A8H5CE82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="1919"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1554"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1708"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1761"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1858"/>
            <end position="1867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5340129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2067" mass="223130" checksum="C5D817FC475956DA" modified="2022-01-19" version="1">MMFFASFFSTLTNDQHLWRELWSAQPFDDPLTCVSPIGRRRTDPFDWKGELQIIIRARTILENISLCKPHERCTTLQTLLNLASWVPPLKTQSDNDNVSQNILWVFALTRGGNFIDHRRIPWEQDEEERQLRAKLHTILGILPMDLENEAIIQARAVVYSMRNYTWANEFGPFKADGRVNWEHVKAIHHTISMHLLPPIEDMDFLMLLYPLSAPRSQIVIPQGVDLDQEDDWAGVEGYWNVSFCFCDHHLLIRYNSSAAPPAPLDNMYISDPLFREVFRTLEVKLHVTRVVPDSKHPGRPQIYFVGVMSHPSTSIMNGYVKMTDDGHVRWHFVSGESGNAIWSCEGVQVGGVRSAYGVLGSWTTIFHDVDDPVGPFLLQKLEIPDLAGVEPAGPAHAFIKARSRPGRESSAIREKVRYPHLDYSSSLSFPYHKYLRTSCSPMSDQPSPPKPKPGSLRDRIAAFEKPAQQASSNAPPPPRPKPGNIPWKPRQLSPPTSPAAADDSTSASGSGSGSGSGATEGSSYKKFGSGMSASDAKESITKGGGGSLKERMAALQGKGGFGAPPPLAPKPAVEKPKWKPPPQVVKAGGDDDDDDNEDGNKPKPVDTEPKDKEEGGEERVKSPDASSVKSGEESVGAEADASEEAGEPDPEEEERQRRAAIAARMAKLGGARVGMGPPVFGRPMVPKKPEVMKSPPATQPTPSQEVKEEVKEDVSNTEPSAAAADGEPLKSPPSIVEEAGTAEEKDTTKSVPDEERKASAATDSSSLLSPDSNASSPPARTTPTSMPLPAAPRRAGPPRRKVKSPVPEPEPEAVSEPVAEPASESLAIGTEEGDITAAPDKEPEESTTTKEERERAHAEPSTQTRDSVDSGSAAAGGPPGGGVEEEETGHAPPIHAHMESAPESPEKVLSDEKLVAEEPKPVAEERDTSVDIVEQHKDAGELEQQLESEETREEEIKGSAAEPVAAGEREVEEKHEYEQSKEQEQVHEEEEEDEETRRKRIAERVAKMGGFNPFSLPPKPQRRPSEDPSSPVSVSSTSQKRTSGISLTKEEREGSIGSVEQQNIRKSSMDSSSGSFPPPPVRRSSQMSAKSVSVASPTSPPARKPSVDSTHLEGVGKQGDDHALSAAASKHITPSGITEEPHDDEDEDDSIPVPVHRASISENKATEEHEDDTRFRNLEGKDESAPRPASISSPPPMNLSSRPPAPARQASTSSNASAAPIFVPPPPPKMSPPDDGAAAVSSPQSDRAVPPPPAVPEDYDVEEPAPPVPQRRSIPPPPRMIPQPSEEQEYTDAEAERKEPHTAVSHGHVEESASPIAVPVPEPRRLPPRRVHDDEGENSDSSVPLPHPHRRSIPTLAPSQASDVEDDVAAKVILPRRMVPPPPPVSAIEPGSDDDDDDEEVPHAREEKEEILPTPPRRAVTPERRSPQQEPLIVPPPPVPAQTRPDSIAERRSVPVPAIPQARVAAEPESVQPSVLSPSLSVSEEDSEVLDEDEGAYSSICIDADPIDPSFHSPSRRASALNLQSASPPPSAPSFGTEPAPAAQPEEPVEDEETVRRRTIAERMAKLGGIRFGAAPIPTSRPAPPPKRATEDDEGQYEDVAEEAPSELTEEEEERARKERIAAKLASMGGMRIGMMPGTMPPRPPPVRTPSVPVESPTSPASASAAPRVPPHRAVPPPVPQSLSHSQEFDSEHESQANSEDGVKVEAEESEIEEVNYEDVEEEAPPPPVPTREGRRVPSGDHAGRPTQPSSRPPVPTALPRRTSTDTTTTRKSSTGSTQNYQTAYQKPHSDYVMVEDPEPAEPVPPRITSRPPPARAPPPPGPPSAGIDPSDSQWEMPSAPTAESVAAPKRTSGRPPARAPPPPGPSSPGMEPAESQWEMPTIPSVDFGRNADLSLSWNESDIPAPVKEPSAPPAPAANQVLSSDDLMAIWGRVGVQICEVATALHDKSKKALIGDGTYHGFVTATLKEVPNTAPISPNSYGYLIYQQSGSAVQKRVSDILPGDILWMQDAKLKGHKGIQTYHQSVGVGDPLVGVVSEFEAKKFKVRVFQANQHVGQQVSSALSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEA3</accession>
    <name>A0A8H5CEA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000181">
        <property type="protein sequence ID" value="KAF5339903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEA3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="9683" checksum="D87DFC25ED7134EC" modified="2022-01-19" version="1">MISSNLTFSLAPGWKFIETEDWRVDYDAGGGAGASTSTSMSGYGGAGTLKADSKVSVDLDYDDAEDEDEDEDGGKDGREDDDFGNGKSGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEB3</accession>
    <name>A0A8H5CEB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEB3"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="42760" checksum="9C54D50377F8B4D3" modified="2022-01-19" version="1">MTLPTGVYRADQVGSLLRPKSILEARQKVAVGELKQEELKELEDKYIADVVKKQIDAGLRAVTDGEFRRAWFHIDFLEQLDGIETRGALQSTNVSKGGTMPPRLVVVKKITHPKSIQVQDFKYLESQIAAAGAQGKVTTKVSIPSPTMIHFRGGRDTIDEASYPTLEPFFEDLARVYQEELDDLYKAGARFVQLDDTNLAYLCDPQMRAEAEKRHGDANQLTRQYAALINKAISKRPKDLTIGIHLCRGNHRSQWFAQGGYEPVAEVLFKDLDVDVYFLEYDDARSGDFSPLRHLPENKIVVLGVMTSKKGALDDKEEIIKKVKEAAEFCPKGLKQLCLSHQCGFSSTMEGNELSEEEQWAKVRLEVEIAKELWGDDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGS4</accession>
    <name>A0A8H5CGS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000160">
        <property type="protein sequence ID" value="KAF5341582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGS4"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="1">
        <location>
            <begin position="482"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5341582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="706" mass="77504" checksum="6D0A836DF7B6D549" modified="2022-01-19" version="1">MVSLRFDLGLTCSMFLRREIALAALAFGLGVSGQTGLAPKQFLTLPLGQVRPSGWLFDQLMVQTNGLAGHEHEFYHYVSQTDWTGGTSAYSSLEEAGSYWFNAMVPNGVLVNSTVLNQKTSAFLDYVLSHQESTGWLGPEVGNNKPRYLWGRYPFMFGAIQMVEANPALTDRVVTALHKFVAVANTMLHNGQGVEAWTQTRWEDFVMVLQWLYDYHPNGNQALLIDTMQQLKFTGVPWEKVFSSQYFPTTATDNLPNPLGFVLSWHGVNMAEGLKALPATYRFTHNQSDLDRASEGWDLLFKYHGRPSGIYAADEYLAGLEAARGTELCLVVVSSDDSSSNVKKVNGVMVLGNDVLVRGLHVFFDVFSIACFSGSYLYQVIGDPKYLDRVERIAYNALPATLTGDFWSRQYLQQQNQIAAQNMNPNPFPNDGPYSNVFGLEPNYPCCTVNHPQGWPKFISNAFLTTPDQKSLVQAYLGPFSTSATLATNNNVFVTVDTIYPFSDTLTTTITASQAFTYYVRIPSWVVGGTIAINGAAAKALSPSNGLQAVQVSAGTTKFVLNLPAQITTESRPHGSFAVQRGPLHYAFDIPRNQTVLTKNAQEPRAVDLQFEATAAWQYAIDPSTLKFVNKPPSSGKLPSPVYDSNLPPLSITVTACPITWKTAGSTFASAPPTNPACTGAQKTITLTPYGSTKLRIGEFPVFKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGX3</accession>
    <name>A0A8H5CGX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000162">
        <property type="protein sequence ID" value="KAF5341541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGX3"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5341541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="326" mass="35587" checksum="F75E7A4B09404FD5" modified="2022-01-19" version="1">MSPSQRIAVAGGTGRIGLHIVESLLSLKSTVPSLHIIVLSRSVKPEKSDITFAGSSAPIIAVDYNDTSGIESILREHNIDTVISALFGDVEVFDVAQQNVLTAALNVPTIRRFSPSELSVDSETADSVTIYVKKRPILQRLREVKAARSGSGSGSGVHFEYTKFVTGVIMNYLASGNPKSSGEDAHGHMFAHKLVFDFENGTAEIPGDGQALLWTSRIQDMGEFIAHATQLDVWPEQMDLVGDVRSMNEIRDLAEEILGKKLQVTYISEETIQSKLDPSATPLAKIGLEGRLSFGRGEMKRSETYAGLKDVVKPVGLEEFLRMWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHC2</accession>
    <name>A0A8H5CHC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHC2"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034253463" evidence="6">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5341478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="15190" checksum="9A710CCC5538EB70" modified="2022-01-19" version="1">MMPRLTSLFFSICFASLVVTSPTIIVSQQGKTRAWPSGEVTCGSDVYTLDEVQAAVSAGVDHLDNPIGDNSYPHTFNNYEGLDLYCSGETDYNEYPIMSDGDAYDGDSPGADRVIFSDNGVYCAVVTHTGASGNDFVSCEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKD1</accession>
    <name>A0A8H5CKD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000152">
        <property type="protein sequence ID" value="KAF5342939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKD1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5342939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="114" mass="12847" checksum="1D3A4F875537A0C5" modified="2022-01-19" version="1">MDNFITLDLSINHDGLDSLTDVDELQSPPLHQDGLKKVKAYCYLLTLSMHRAVCLPSVLLPKPEATCLPGLLGLTRDALPLSTLRYFVITSPHFHSFNRLINPRPLHLHHSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKP0</accession>
    <name>A0A8H5CKP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000139">
        <property type="protein sequence ID" value="KAF5343505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKP0"/>
    <dbReference type="OrthoDB" id="2974599at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="31228" checksum="A2B0AACF685D99D6" modified="2022-01-19" version="1">MTSDSSSSTMLVADPNTGSGSANQLRLSNRPLHEFFHRRKRSHSGPQSRFSFTSPTGLDGHNHIHAYPHLQTHVPRISGPALPTYASYANDNTRSRDTPHDFSMTPANVPSAYQLYQMQLGLGPYLARPEEAYSGPRTGAAYIDEGGRRLDSRPSEDGDGWDGDGNGEKDLLPVYDMNGGPPRYSEDVRASGDMAGMRGGIGMGSMGDVGGVERGDANGDTLAGRDANVDSTGTYTASGGTTHTSILTSTPTPTSASTATSPSGTHDERTIPTMRSNSDSASESQSQALQLQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKZ1</accession>
    <name>A0A8H5CKZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKZ1"/>
    <dbReference type="OrthoDB" id="2906386at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="365" mass="39750" checksum="6978AA47E6C71782" modified="2022-01-19" version="1">MPKYLFVEQDSTQVSSTASQPGSSTFTSPPSSVSPSPSPGSPSTQSGSSHAKARRKTGELKEIEVIVRDMIGSGKHALLPMNVRVQSVGNGHEVKPIEVLRGLRDSFTFFGFCVGYRVYCMALLLDVGNPFGGSGGVYQAFGMVDGPEYELTSDAPKSLSLDDGFRLYVKVEMVGVSSHPNANATLDNDTDVQASGMAPPSDADVAAPGRKRKRLQKDDGEEDQPFFSSLLKEIENREGYAAFKAAKGKAQSHKLQNPDIKEYWAFGVSCVDNLAGMILNDRVVMKKDIHKGLELPSSWFSDARKGLRLIEMYGPNGREESKKVVTELNKVSDTPRGWTALLKFLLKHAEDVNKSYTGMVVNEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMA2</accession>
    <name>A0A8H5CMA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMA2"/>
    <dbReference type="OrthoDB" id="3144234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="72"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="223" mass="24907" checksum="939F38380C41DA9A" modified="2022-01-19" version="1">MGHRVRFANPSADQVYLYSPTSSTSSRSPGPATPPSPHSSLPQSSVSSPLEVILVKGFHDALRLNSKDTLKIDLSVDPRTNPSLISSDYFSSIQGEDATIPPTGYVELWSRWLPWVIEITPKTGPHVTVYDMLCGLYDALHARMTEEEYHASTDLSRFPGIRDDVDSAFKKRCDKIMEHNVGLAEKERNNGRRRLDLLRGNNIFYGLSVDPNTEVVKFSVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPJ9</accession>
    <name>A0A8H5CPJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPJ9"/>
    <dbReference type="OrthoDB" id="3346251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="41276" checksum="638946167D920426" modified="2022-01-19" version="1">MLGPFDERSLTLDDRSYKLTAYLRVSSLAVALYDFISTLPSSWRFYKEQWDAPRLTVSFILFFLIQFISIAALTISNVGFFYSHFTETSCHHFYLLPLIFKVLQAMVSQAILGFRSFNLSRRSQRISVLLASFYVGACTLEWITTLYNRQPVVDPKYGNCRAVLENLYFGAWIYYVVAMIYDLFTTSIAITYLLKHKLSTPTTSLFSQLNKIMLYDGIGYFAALTAVNILNLIIYRAGQDIQSAAASLGYCVTWIMSQRLLIHLHDASLERRFGSIDEAVTISQGVSSARDVTRIIRSQFDSKTGLVSLDLTIPDFELESSDCGTFEHADEVSVQVRVEKTVKVERRPKTYTLENYSRHPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CPL3</accession>
    <name>A0A8H5CPL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000111">
        <property type="protein sequence ID" value="KAF5345525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CPL3"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="248" mass="27384" checksum="C58D64723E69E7DF" modified="2022-01-19" version="1">MPFYTPPTDPYSSSSSNSATAVSSPWSRAQHHSEPSSSFLPPFFSHNDPDPSQEPPTRLALFSSPQPHAEGSMGEIQLAFNIFKVFGTPNDDIWPGFSQLPDAGRVVWREVEGCGLKGRLNLNFGHDAQDIDMTVWETEERAAENHILDFLSRLLVYPPERRVPAKEAMSLDFFASPSSLYSSSARTGSSADSSTTRPWLLLPPSYPPEALPETLRSSIRHSLELEQDNIQMTLGDLFLGVLGRTSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQ50</accession>
    <name>A0A8H5CQ50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQ50"/>
    <dbReference type="OrthoDB" id="3164380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="27653" checksum="45796F67E4DB68E1" modified="2022-01-19" version="1">MASPLESFGCLDELIQIIYQSVHRFVLLSNVTEEEWTVHLGLSGSEGRWWRGVWKDKDVFETIGSISKATGKLLEGFAQKLADCVVNGDIFISDWSSAPGAQIKVKRPVPRCKPDKKPVHIPLTEISAAEAASFSTRMFLDIAIQAKSRKNQLHGGAELPALAVSSTFSTTDFDIGKPSASSSVKDALSASDEAPERKSPAKKREEKAGKSTKRKESEPPQPKLARTLKGASLVNPNKKARKFKAQEFESDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSA4</accession>
    <name>A0A8H5CSA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSA4"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034655101" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5347091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="140" mass="14520" checksum="A8EE99DF87BF6E7E" modified="2022-01-19" version="1">MFAKLFQLTAATVAAVLAMSITTQAAPAASRALVRRNVGDGTLYNPALGACGISNTDADMVAAVSASFFDTFPGATANPNLNPLCNKPISASFNGKTITVTIVDRCTQCVGQDLDFSPTAFSQLADPAIGRINGVTWDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSM7</accession>
    <name>A0A8H5CSM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_011516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSM7"/>
    <dbReference type="OrthoDB" id="3059882at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5346321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="23273" checksum="E178C22711A14E85" modified="2022-01-19" version="1">MVWLTATRTAKLLPHLWYRPQDIIYVPAFILFGYYFAIMKLYALCTLHETAWGTRTGIGDIAAATAAMDKQAQAQGQGLDESASKRPIEKIPLAFGSRSDSGSGSGSGSRSRSRPSSDLGPSPGPSPLSSSYPPLIQIQKDPFADDTHAHAYEYGHRYGERRDGVGGSADMGMVGSTSFKSEVQGQGYMRRRGDPFGDAGEMEMGAGLGSELGSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTV1</accession>
    <name>A0A8H5CTV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTV1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034401545" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="42"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="46664" checksum="8D1B5F46CC448090" modified="2022-01-19" version="1">MSHFSILRTVTVLVFLTLGTINTASAWFRLPCTDPLVQERIDPIISPGKIPSQHVHTVHGASNFAANSTFDTLRASKCTSCQVSQDLSNYWFPKLYFRDPKTKMFEAVSNGGELYIRTHRLEILFIYVKGLLIYYQNRGSLDKINGGPGLKAFPPGFRMITGNPVKRTKVYPDGLGTQEELGERAIAWACLRYTTSNADYYGTGSFPHTDCEVRHAAWFHPSLLVSKVVFISPRAGTARQNVDSPDHKSHVAYLSILDNGSCPSTHPVGLMKLFYEITWNIHDFTGRWQESDGWPFVWVNSLSIRKKNFPDLFHPHRLLETQLVIPGTVISKTDGTLIHPGSVLQKAIDNCNNPNDDTINGVISACPYFNLIDPAKAVTCKTNPVVNEPVSGSPMAKLPGCNPIQTGPGDATLYNEANCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUX2</accession>
    <name>A0A8H5CUX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUX2"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62448" checksum="C6E76A9109CE3C2D" modified="2022-01-19" version="1">MPTTQPPNSSFKSLTSVDSTKLTSRLRRTCGLSGPDIAHISQFLLNAESDVKNYQSEIRKRHAEIVSFQNRISGLQRHMEACRSLLAPIRKLPLEVLTKVFIEFCAEETTMGKVFGCPPLTLSHVSGGWRELALSTPQLWSTIDIDFDHTKSRDSDEIGWSQLVIEILIRSKKYSLTLSIHSGDTIENLQDADIRLIQTLAAQSERWRDVTLELDADSLLDESLSVIRGQLPMLESLTLKNLWEYPDFPEIDIFDNAPKLISFSAGSVSALDPTLPWNQLTNLQLTDCSFLEVLQLMEVCPRLHELTYVGDFYQNEAHPDYHPEQIRSFNHVNSFTIKTTSVNDTFMLRSMFAWLSFPPLETLSISADQMMPAWDWEEIPDTIALFISNSGCRLTTLSLKHMQLSDVDILSILEACPHLRKLVLHGWKYEEQHKVNPAVVVNAGVTTELAAKLAVNHAQYNPASTPIVPKLEELEFGFHYQSALFSGRRLVAALCRLVESRWLPDKEFADDIGVTCLESVSFVVMGSDCKAEYFTTPMNLREVGLRLEVSGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWP6</accession>
    <name>A0A8H5CWP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWP6"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="161"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="72054" checksum="45033F568051A769" modified="2022-01-19" version="1">MTQMMPQEQESVSLLASMAAVDHGIALRVLRKHNGNMERAAEALITGDRGESPQPPKTTSIDPSATVIDLTGDDNDEEMNRALQMSLDESASQPQFGPSTRPPDPNWSMVPASGSHLSTPRQSTQEDENLKEAIKASLAEPDNESIPNTDDMVRDEDGRPVALRPDDPSLAYAALVLHALFHVPQVRQRLSRLMLPTSEQDLKEDSAEVFMFKLLELFTNMDLAKISAIFGNDIYDSLRTPRATQPDLPVEISRAFIDPVTRIIEQCLEIQEAQESPPRQSLFMFSSARIEISPLRSSAPHRFERGTVVTVEVGHDPKLPNELVARLASILHTVDGDVIKHEGIDKPSEVVIFQLKTYSTFSTSNLSMANEGFVYPRLIYMDRFLLENFHVTNEKNKKQREIISLIADLEKKKEEITKSDNTDTIANLKTAINYYENVARDGNMPERRTTLDTVTQQLKTTLAALEAKLERIDIEVNDLRQKLDNLFECPELQNHPYELRAVLVHTGLSGRKHIYSYVQDTQCRWWKTVDYTVSQVSEEEVLGDTKGVALGAGPYMLIYSRSLTPEQLKEPCPWPEAYVAAVNHHNETFLATLKDGYSVVQDSNAEASDTVPALPPRPREREVVSLEQKANEDVSMMDMTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D222</accession>
    <name>A0A8H5D222_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inhibitor of apoptosis repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D222"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5351323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31885" checksum="C391E7D3F9A32711" modified="2022-01-19" version="1">MQVLQNRINSFSSKPKRKQGKSHNIKWPHPEYFTATPVTLAEAGFYYDPSPEDVDNVTCYMCGKELSEWAEDDDPFDIHFKKCGKKCAWAVVRCGLRSDMDQKNKFVFTDKNRLPTSKPMEKARLETFTYDGWQYDSVKNHSASSREMARAGFVYSPVEVGDDLATCLYCGVSLSGWEPDDDPTEEHRKRVKSSGIPCPMFPDIVISKSYKDTTVPTKIHDGEEDEDEAPARAGSSTSKTPRSSHAKSTAKTPRSRARSSSKSRKATGEEERRGGGGGGGCRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D3Z9</accession>
    <name>A0A8H5D3Z9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_008740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D3Z9"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="180"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5353085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="425" mass="47181" checksum="B3DA03A33684B6F3" modified="2022-01-19" version="1">MPESAGRVLLAYSGGLDTSCILAWLIEKGYEVYAFMADVGQEEDFAAAEKKALKVGAKKFFLEDLRREFVTELIYPAVQANCIYENVYLLGTSLARPVIARGMIAVAEREGCDFVSHGCTGKGNDQVRFELAFYGLKPDIKVIAPWRIPEFYHRFAGRRDLLAYAAEKDIPVAQTTAKPWSTDENLFHISYEAGILEDPNTTPPADMWKLTTAPEDAPANPEKITIEFKRGLPVKVTVEGQKTYEDPVDIFLALNTLGRKHGIGRIDIVENRFIGVKSRGCYESPGATILRAAHIDLEGLTLDRNVRALRDQFVTIELSKVLYNGHFFTPEREFITSAIPASQRTVNGLVKLKLYKGNVVIEGRSSPEGLYDEQQASMDELGGFEPSDTTGFIAIESIRIKKWAQSNIAKGQAGVEPKDVYGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4E5</accession>
    <name>A0A8H5D4E5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000068">
        <property type="protein sequence ID" value="KAF5352042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4E5"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="38618" checksum="5CEA5ECBB1392B3E" modified="2022-01-19" version="1">MYKPVVAANPIVQAVEPFSTSLGIPICNADTPHLEGTDGLFFADPGKLYLLTTRHVLFHPDNEPNELYKYREDSGQPRRKVLLLGEAAFKDRLKAIESETGGKQIIIDQFNRRLNDADEMENKEDAEMEREMVLPLLEQAKNAIESSRSSSLMSLENGRTRRSVSSATSFCPRSSVSTMGTTASLIIWAVVEIDSSMIDRFSFVGNVIDLGTSIPVDELTTSMYPRLSNPTLFNYPENRLLKFHGLSQTRRCTSLTQRPKTRDQDDDPVTMVLQNGCTSKLTIGPLNTIRSATREYFQGKAAAISKEVAVLSRTSKSKPFSKCGDSDQRYGSSCWNNHWRRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D4N5</accession>
    <name>A0A8H5D4N5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000063">
        <property type="protein sequence ID" value="KAF5353582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D4N5"/>
    <dbReference type="OrthoDB" id="2654453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="173" mass="19456" checksum="F883103D6269B087" modified="2022-01-19" version="1">MVISGAAISVKDNAYILDDTSQGVALYKLSGAERLRTFAVTTNERRSRNVGFHDGGKALISGSDHGDVYVFDRRTSEVNDIIQVGCKDWVQSVTEQTMEMEGVPIIIIGRSGENLGQTALQVWERETPAPEREGARQGRLLQDFYWWQVICVLLSILFVMQNLNREHANGWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7G2</accession>
    <name>A0A8H5D7G2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7G2"/>
    <dbReference type="OrthoDB" id="2890847at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5354564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="418" mass="47819" checksum="4DC2C2985636DB1A" modified="2022-01-19" version="1">MTIILCDQCGRTFVPTLQDENRLKCDMQDELRERFLPTDTESSQIIEDIRQLDGEITQYNLEIDRLRETLGTLEKRRDILLRAKETRQALFSPIRKLPPEVLGEILSLCAHLPERNAREIVSLHDRGYKRPLASLSLPILSVARTCRLWRDICLEKPDFWTDIVFHFDSMYETSYSQANIDALTSLLRRYLGHSNSLPLNVNFHALGPYGTDWDWDSPTDFHELCSQVLVVLLEESQRWQSVVLAIDSELFALELFPHEGVSELIECFSQTPSSSFPRLESFVVVDQSLAWQSSFVRYFSAAPIRNLLIPSYSDNLLDTLSEAHSLIDVTSLTVSQFDNACCSILEHCPNLERLNILNCLIVEEEWAIHTCPKLANLEVSLSDGEPHSNVTDLFEVLNLPSVLSRGDRKAYGRFHFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D7H7</accession>
    <name>A0A8H5D7H7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_011219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D7H7"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5354594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="181" mass="20288" checksum="1BD483A904456BBA" modified="2022-01-19" version="1">MHSLYSRVNNLSAFLSTCTMALLAAIALSSLLFNADPKGDLSIASVKVHPAKSHRYPRKKMENGFVNFNITADLTPLFHWNTKQLFLYLEAEYQNTKGVNNSVVIWDRIIRRKEDAVINVAGRNKYAFKEISSSFKNAPTAGSHYSLKYNVMPYVGALTYGEAARTSEPVEFTIEAAPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D858</accession>
    <name>A0A8H5D858_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">D9758_006032</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D858"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="24">
        <location>
            <begin position="217"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="23">
        <location>
            <begin position="517"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="25">
        <location>
            <begin position="985"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF5355326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123121" checksum="EB12E08737BA2C52" modified="2022-01-19" version="1">MPGPLTSASNVLSARSRAKPELDSNSQPSVKKRKLDQSYSQPSASQSKPSFVDVLEKLNSERGNQHEGGADQWARPALLNLDEKKDKIVFQQIDIEYHIEGNVTTLRMYGVTEEGHSVLAHIRDFEPYFYIAQPRAFTREDLEPFKEYLNNTVGMECVVNIDIVSKRSLWGYKGDAFVPFLKLTLTDPRSVPKVRDECIFVCRYRLVLTMRFGDSYPTYESNIAYTLRFMIDTKVVGMNWIEVPAGKYHIISPEKKKSHCQLEFSVRWDQFISHPPEGEWQKIAPLRILSFDIECAGRKGIFPEASIDPVIQIANMVTRQGDPQPFVRNVFTLNTCSHIVGSQVMSYDDEAQMLEAWKDFVQEVDPDVVIGYNIAGFDFPYLMDRAAALKAKKFPYLGRLKNTPAKVKDTHFSSKAHGQRDSKETPLDGRLQLDVLQFMQREHKLRSYTLNSVCAQFLGEQKEDVHHSVITELQNGTPESRRRLAVYCLKDAYLPQRLLDKLMCFVNYVEMARVTGVPFNYLLSRGQSIKVLSQLFRKANEEGYVIPSFKSEGTEDQYEGATVIEPTKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLDRAQIERLGLQKDVDYIQTPNNDCFVTKGKRKGLLPIILEDLISARKRAKADLKKESDPFKRAVLDGRQLALKISANSVYGFTGATIGKLACLPISSSVTSYGRQMIEETKRQVESEYSKANGHDFDAQVIYGDTDSVMVKFGPNDLERVMQLGAEAADFVTVKFIKPIKLEFEKVYYPYLLISKKRYAGLYWTKPEKWDKMDSKGIETVRRDNCRLVSTVIETCLHKMLINRDVEGAEEYVKQTISDLLQNRIDMSQLVITKALAKTDYEGKLAHVELAKRMKQRDAGSAPALGDRVAYVITKGVKGAAAYEKSEDPLYVLEHNIPVDTRYYLDNQLSKPLMRIFEPILGEKASALLNGDHTRTIQIATPTVGGLMKFAVKTVTCLGCKTPLRANNSLNKDGAVCKNCRPRMAELYQKQITTASELQVRFSRLWTQCQRCQGSLHQDVLCTSKDCPIFYMRKKAQKDVEDADTVLERFDVNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8V0</accession>
    <name>A0A8H5D8V0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8V0"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="824"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5354367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1019" mass="108536" checksum="C70677ACBE60B956" modified="2022-01-19" version="1">MNNLLRTLTESQFKPGAGNTDLKLLLTSVKEFRRSQSHDTKLSDPFYETLEGLLVDLKTVSIDNHDAEAFLKPVLKAEVPDYYDVISNPMDFQTMLKKVKQRQYKSKKEFKDDLDLIWSNCFTYNASENHPLRKCAQRLKIKSEKLLANITDRKERTDPPIPPELSSNPSSLARIKLNGHVLTNGRSYTRSPSITKTALSSKVSTPTPGKAIVKIPRRDLPFSDSPAIVRTAEGMAMFRELDRSFEAGPSTQVIDRLRELAPHVEYEPDPETSDVEVKEEIDEAVALGDKRKLNGFSPDNRPHKRARLNASSAASTSSTYDKALPLWWAASQSDYMLANALPEIPYASSSSSSSRKVHPFSLPALPSNPTNSSHPTQTQRHPSHPNQLTKRKKRRKRPYDVEPYRPEDHPKALLSLMNNNVKTMKRIRHAHAKFSALGITKDLGAAGDDDADNTNANAPNAATSGAGTSGGNGNLGAPLGTGVASMDVDDVEDDQVDERPWRVPMRNGKKVSGIELGAKNAEECLKWADGKVLEHAGFQGTSKAALDVLYGVTSEYLLNVGRTIRFLCDKFSNTMTAEEIILHTLFESGTSRIQDLERYISDDVERYGSRLGDLEKKLVGAYREATAVEVLEDEGLFEEEDEEEASALALGEFGDNVGLDYFGLKELGIADEFGLSSLTIPKRLLKGKKRRNIESSPAAKPTEPPPPFPPPPPLVPLSSDKISEQIGLLQSYYSSRVATLAPPPPPPVPVGPPPLAGPSIPTIPGSLSGPTIPPLSGPSIPSLSGPSIPPLSGPTIPPLSGPTLSSPTVPPPPPGPQLHPTPTPTQTSTPILTPSVPPTQVITSSSQSSQYSTFTATSVAPAPTGLPPKVVLPDDMPAPVQAKMGPLGQILKPNASQATSKKKAKGAAGAGPGPVSASASGEVKPLVNGTGIGGAVTAANGVPGSDGPGAGTGAGAAPKKKKGVTGVGNGNGRKKKLMEAAQAQAQQAQQGQGYGQGQGQGQNQNQGPSAFPPAVTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5EQQ2</accession>
    <name>A0A8H5EQQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000699">
        <property type="protein sequence ID" value="KAF5308981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5EQQ2"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5308981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="495" mass="55643" checksum="5B11CBABF9DC38DC" modified="2022-01-19" version="1">MLILYALARPLLAPDTAVLVNDTFATTDGSGFDRCGDIRSCRTTEEIIYSCIAVVFICIWVAIHPNIPRKFDDDGDEDVSDSEYPGVHSAVVTLQNILFMLLALIVPELIIMWAMRQWLAARAIARKYKKYNWTKTHGFFVVMGGFALYDGDKFLHTLEDDEEFTMKEKAVAVKIDEFIKVHLKSKEEQASTASIVSRPEGPTSRLLPDRSEASCMLEFLLQRKLISVTEDEIKDKGKSDALSKFLAIGQTAWFIVQCIARGVEGISITNLEILTLAFALLNFGTYFFWLDKPQRVRFPVKININYQSQSSQEGGTAGSIWDWFQAIGREIGSDWKNLYDDHPLVVIPYPLITLFNQSADLTVGQSHYQTGLKKDPWHLYVSVISIAVIFGAIHCIPWAFTFPSHTEQIMWRVCALGVTCLPVLGIVLISIILIIDELLGSTWCSELLGISIVISFPIFYGIARITLIILALMELRALPTSAHQTVEWTTLIPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F477</accession>
    <name>A0A8H5F477_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000395">
        <property type="protein sequence ID" value="KAF5323215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F477"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5323215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="97" mass="10514" checksum="AA248E66C5CF9E19" modified="2022-01-19" version="1">MSSLTSSSEKPRKTAIVTGAANGIGRSIALRLARDGFNVAMNDLASQRDRLVSLSEEIRALGLGSESSIHVGDVSVEEDVREWLKRWRGGLVVLMCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCJ2</accession>
    <name>A0A8H5FCJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_016562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000315">
        <property type="protein sequence ID" value="KAF5332050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCJ2"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="71"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5332050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="35708" checksum="55F7FC0FB2F95F46" modified="2022-01-19" version="1">MSTTNTESVLGQELTPSQIYDLNQSLLNEATDVSRPLIDSLVPISHLRKEYENGSKAFVDQIDWLTEHGYTHIRRARGDGDCFYRALSFAYVEKYPDLTHLSTTPNLLESVGFQRLVFEDFYEVLEDLIKRVQAEPEEMREVLMESAFQNPEVSNSIVMYMRLLTSSHLRSHAPSYEPFLFHPETGLQLDVREFCEGWVEATGREADHVQITALSRALLIDVDVAYLDGRVRSSEEKVEFVKLRPREDPEFAPPATTTEATETTIKTPTEPIVLLYRPGHYDILVQGEKEKERGVQEGEGQAAEEAQAHEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDG3</accession>
    <name>A0A8H5FDG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000303">
        <property type="protein sequence ID" value="KAF5332428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDG3"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="33956" checksum="9B7880E8E8F1E60B" modified="2022-01-19" version="1">MASVSPWFFYPCSPSIFLYTADQHLYAKRWEALVDTSFPTNDSPSNPLNIDIIQIISWNDYGESHYIGAIKGAQPVGTWFPLTFYYTSAFKNGGQYPDEKLVIWSRTHSVQAQVGDPVEEVTGRELVEDTVWAITLLAEPANVTFEVYAYTDTPSSSNDNISSQTFSVQAGLTKLAMPIGFLDGDGDGGTEFECSSVVRSASTSRSGSVSESQDKDQDKDTQQTQDTTDTDTDTDTNADTDTLVMQLDAGNPKPLLNSDSDPNFNPNMNAGNGQGDGQGQGASPSLSPLVFVVKSPEKYNHDARAGCVSSSGAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDK9</accession>
    <name>A0A8H5FDK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000300">
        <property type="protein sequence ID" value="KAF5332909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDK9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="24517" checksum="34FD66D9CD5BB320" modified="2022-01-19" version="1">MSVSGSSSSSSTTSATSGTDSSTGSASNPSGTSPTNSISRSIVPTTTSNTASNTAGTSPTNSISRSIIPTNSNAASNFGAAIDGTSIPSVTPPTDIPSGTSPTDIPSGTSPTDSIISPSQSSASTSAHHSTSKITGGAVGGVLFLLLAAILILIRRRRSHEQDSETGSMVSPFLEGQPLDRVPHTAELSVTEHVRRKSDEAIAVQAVYVDSGWRMPIGQAQAQLGSSDIVSIPPPPPHYTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDV1</accession>
    <name>A0A8H5FDV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_017005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000300">
        <property type="protein sequence ID" value="KAF5332907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDV1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5332907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="36635" checksum="65435A0EEB4747D0" modified="2022-01-19" version="1">MTEFFLMSKLGQNASTGKAKSTIESELLRRAFWCLYILDIIVSTFMNRPRAISMDDLEVDLPIECDDEYWETDDPQHAFQQPLDKPSYVAACNAFIKLLDIMSFAQHSLYSVRRSHFWTTSGPGLSGPEWNEKVVKEIDTSLAKWLEDIPSHLKWNPHHPIENQNFFNQSTFLHAMYYWVQIFVHKASIPQISRHPGAVSTATVKLSQNSPSLVICVNAARSCCRVMEEQNKREVLPLHNVLMALYTSAVVLILNARREKRLHMHMRTSTGEGDVDVDVSSEMVDVYKCIKIIQSCESRWQAAGVELAHSVAAINDIYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FFP8</accession>
    <name>A0A8H5FFP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000252">
        <property type="protein sequence ID" value="KAF5334738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FFP8"/>
    <dbReference type="OrthoDB" id="3014170at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="38480" checksum="9106F8ECEB93B99C" modified="2022-01-19" version="1">MSIAAFTALEEFYKDHSSTSPVPANPADEEDWVFRGIADRADFACYMTSKYSLSDKSKIVISPMHFREFLAEVSDDGKEVKIIKKQGMFEHPLILKVLSTYLSCVDTIPGGIQRLQGKPFGALEIAVQAVERALTFYHTGQSTLDLTQSEHHFSYVNWGSQPVKNAAGEETGKLRHEEFHNTIRKLSDEKWKAILDGARSLMTTKRKPSKKAAEPREAEGEDEDDNGDDIIMSDPPEPVADSVSQSMLQMAGANDIRNNGNGDGNGDGNGKENEEGHGNGHDGESGEESDEEGTGDDGRMQEGGSDCDSDGTGRQGTGGDNGYSADEGDGNEEDVDGSGKAESGNAIVEQSDTEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNU9</accession>
    <name>A0A8H5FNU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNU9"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034395921" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5344110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="25673" checksum="B85CC9C967406EAE" modified="2022-01-19" version="1">MSSILSLFMLISVVAGDTVFTPTAPGPGDVFKAGKDCTIAWKPGNWTNVTITLMSGSNTDMNLVAPVAHDIDGSDPSLSPFTWTCPEVDPYSAIYFYQFKNGNDTTWTTRFTITSPSGSSNTPEHSSQPNGDAIPWGIGSLRNSSTTTNAQSNPPRPNGETDQSSPASSSLAQRTAATMNQRQATPTIVFPNISSMTQPTSTTSTTSSLTGHKAENGVGFLGPRLTVPLAVFVLPGLYIYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNV1</accession>
    <name>A0A8H5FNV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_015608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000141">
        <property type="protein sequence ID" value="KAF5343377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNV1"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF29">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="472" mass="52144" checksum="170D0F88968C1410" modified="2022-01-19" version="1">MSESSNSTYKIEPLKGGDNYRTWKVKMIDILTDLDLLEYVDGSRAEPADQSAKEDWKKKDRKALSTIRLRVDDSCLIYVEDSKTSKEAWDALNDMYEAKGPIAIVLLRRKMFTVRCEEGGDIETHIKLMRSYQSQMNTLGQKIEKADFSMLLLTSLPDSWDSFISTFGSTDLEDSNKVIQRILQEASRRNERSANSDAVLTSSSKPSGKSKFNPRITCYCCGRLGHIAAECRCPKCRNKSGNSQTSNQSRNNRSSHAHVAEAPDSDSDKEGPTYVFAAVDAAIPTVSHTSGLSSDAWLLDTGCTRHVVRNKEYFVDYVETPGHQLIGLGISSGLGTGTVNLTLTEGKETTRIALSNAIHCPTAPYNLISVGKILSAGITPVFRGKNQLNLVNSHGTIIGHAVKTAGLFPIDASVDEPTRAHPAIAEIDAKTWEEWHRFYGHLNIGSLKLLKDKATRRRSLKKQSATSLNPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP62</accession>
    <name>A0A8H5FP62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000130">
        <property type="protein sequence ID" value="KAF5344006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP62"/>
    <dbReference type="OrthoDB" id="2757916at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="754" mass="81263" checksum="BA65BBE9CD26086F" modified="2022-01-19" version="1">MWYKPPSVDYIQKLLHYLNMLQPLTQQSLPDIPPLLLPALRTASTNVSSTDTHCPSLKRVKSNANIDEYFSQPRSGRTTCGKAVVGESPGDKSTPSAGLVPTLTSTPAHKRTKPRPSPPPTKSQNETLTKIKTVDGDAEDISAALSESLFAEVLPTPKPQTVSRASIAAARLLRLQQEQEKDDNDAFGMSEAQYRNLVSSFSTVKFEFFDLDGLVWTGSALKRANDTAAAAKRRRGSSGTGVGTVSEDKENVDVNESPLRFKRPKQKNEDEGTRFLIVDEDIEGEDGDGEYRGEEDKNQTIRASVSPFTVEALAMLTRPPRSRYRDKSSECATAPVTASTNAKNDTFITTPITTADASATARTRTTRRTRPMGPADVNDFFFPGCNADAGLDSASVSQSSSSFSSSPHPNSKSASALAEVASEAKASIKTDAATSVPRITTPAETKPEAESICRGRPRRTRSQSIMDGGVCGEFVRSRSRSLSRTRDISDSVADGWVGGEEGDGLADADAITIPCKSFLDDSDSDSSVSQPGPGTTGTIRASTFQCRPNAFAVSTRRVSESQSDTALKLDPQEEVEKVKKAAAQDPPPRPPRAPQRLHVQPRHGQDDDRPRPSLTNCKITTMTTPASTAAGEPLSAPPVSLRRSPPKRSKGLVKPKRIRTPLSPTQSHTKSNSKCDASVGPESTSNSAMAKGLEIPRSKAGKGKGSDQRDRDPFATCGRSFRQMMEVEDWSDDYEGYGDLTAGLYPDVVSAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ89</accession>
    <name>A0A8H5FQ89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_015150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ89"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034426398" evidence="2">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="36258" checksum="D2942409059CCFCB" modified="2022-01-19" version="1">MNKWIVLALFTSVVHALPRSGVERRDTTVTVPSTITITQTQPASTVTITQSPTTVTKTSTSIRTRTSTQTQPASTSASTVTKTQTQTQPASTVTITQGSETVTKTSTRTSTTGPLPRSGPNLLQRSLRQAPVSPPLLMDPGSTVTTTQPGSTGTITTTETDVTTQTQLSTVTTTDATTQLSTVTTTDTMTTTQLSAVTTTGATTTTATTTQIEPTTTTELSLSTVIRTDATTTTATTTQVEPTTTTELSLSTVTQTDATTTTATTTQIEPTTTTTTQLEPTTTTELSLSTVTQTQTDATTTTATTTQIEPTTTTELTISTVTQTDATTTNHSNYRGHDFRHHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR93</accession>
    <name>A0A8H5FR93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR93"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5345882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="92" mass="10355" checksum="E65C4BC1C2121349" modified="2022-01-19" version="1">MLGVHIASFLIFSIPLTLIVVWDKKISSTILFMSMLEQLESVIDRFSSSWFWLHQHSLQQEEGFVWLTPVIGGAAVGAKTLFCSFQPVIVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSJ1</accession>
    <name>A0A8H5FSJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_015067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSJ1"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5347489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54983" checksum="68A8178B722447C5" modified="2022-01-19" version="1">MHTTVRNNSKATQLQVLLMTAHLMIILKSKGHGGSVSSLRATTDIPSIQTFEEILSDPQFRQTLLSNFFEYSADIGFFLNEDEFFNSVVSLNTPHRASPIIPALVSIVFLIASHFTPYPQITALEPVLLLKAKEQRSRLLLGMGTNRPGWTVVQNIQTHVLFAQYFFVIGCNAEGKDSLTNAVSLLLSAGMHRIDSEQQSVFVVAGLPEGSNHSQASNEYNQSTSAFWTVLSLNSCLTAVETEGSKTHFPYWIPEFRVDTPWPQVPVGASSGSTIQNFLVHVPDNGNSAMALHAKACILLEQASQLGKRYDLNTTLDPSSYHDFRNILDNLLSLTTRFIAGLPHTPSNQQAEYSSYRPLPSSTKRQLLVIHTLARMALIRLYLVSEMINHSDPNQRAVARHYQVEVAKEAALMIPSADLQQTVFVNPIMAVLWSSMAHILFSAIRSGEHSAQHNTDFILTDLQHAFNAIIDALSVLSAHGPTMKDQLMSIQLLLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV79</accession>
    <name>A0A8H5FV79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV79"/>
    <dbReference type="OrthoDB" id="3012488at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="39999" checksum="84D10A28F4A1FEDB" modified="2022-01-19" version="1">MSEPTTSPFPDRPTPISQKAFAESYGGTLICCFFAILFYGVSLLQTYMYFLKYPKDTTWMKLLVLIVTVLGTAQIILVCATIYRYLIVSYTDPSVLAGGTPVIFTGVILGYLVCIMVQTFFARMIYHLMKGMKRYLLITGFVLFILSEFAFGMCWVVKEFQSTTLAELAPWAPKLLVPLRILRMVSDGATTLSLCLILFDAKIQFKPSMKLVRTIIIYSINRFVLTTIVGSVQTILILINPHSISVLSIEFISLHLYINSLLAALNSRNRVRGSGRPSSSYISSEEIRPTPTSVNLPGMSSPISPADTNSPQTPKSPHSLPSPISRSADEYPSLRQTLRKGLKINVETESYVMKDIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZG1</accession>
    <name>A0A8H5FZG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012413</name>
        <name evidence="4" type="ORF">D9758_019127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000626">
        <property type="protein sequence ID" value="KAF5309638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZG1"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="3">
        <location>
            <begin position="72"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5309638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5354462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="304" mass="34607" checksum="78B5E667F175B727" modified="2022-01-19" version="1">MHEWQGRHWRKRIAREEAEEKLRKAEDAARDTIAEAERAKDMLKKGPGIQPVSWPTPEEYARTLKARQYQEGDFNFAVAGLSGSGKSFLVNPFRGILDRNTKAAATGITETTSVIGRYPDPNPDHPFIWYDIPGADTLKVSDWEYFNQQGLYVFDVILILFDNRFTATDITILRNCAHWNIPSFIVRSKSDQYIQNLEKGLKEAVEEEVIDTDERRVQLEGIPKAALEEYTTKTRRSVKENLLAADLQNQRVYLISSAAVRSLIRGVATGVLRYLDEEDLITDIVKAVKERRFPTGSQHSPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZU1</accession>
    <name>A0A8H5FZU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZU1"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5355286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="114" mass="12130" checksum="0C8D8DCD85FF281D" modified="2022-01-19" version="1">MAPTKKSKAAKSTESITARLALVVKSGKYSLGYKSALKQMRNGKAKLVLIAGNCPPLRKSELEYYAMLSKTQVHHFAGTNVALGTAAGKLFRVGVMTVTDQGDSDLLTIAENTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G042</accession>
    <name>A0A8H5G042_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G042"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="169"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="650" mass="73407" checksum="B1387BCB5B8BACA4" modified="2022-01-19" version="1">MTSMTSTDNLRASCAALRSNLLSLKNFASRYLYELLDADDPKLSIQTLCRSALPLCYLFNLLPEQFFPKIDVDLEATDEHSRSIAIALFAMNAKRVLGCQYFTLGEILHEDTEGLQKAVNALSAIIHLLPDSEFDRGTTPSPSNPAISVSGSTAHPASSDFTDTLNETIWKNRVRTMLNSERRYVKAVEVIERYSVALREHGPESIQETVAHVFPKKFFTFIRKFCIQLECTAQLPPQNQRWGRLFADTAMDIQILYKIYCVNRILAETKLHEQDTRLLQMQAHPSSSSSITQLLDRPLEHLSDYEYFFDALVAASDSDNAHYEELLTGRAIIKATVAGVHFAQKQTKTQEIIEMLKSRVSDWKDLIIDDAGFFDRRGTFLVRINEGAPLYSEFYLFEKELVFFHDRLTTTTSRVGGRRKTVSSTINPSAKPMPLNLTCHVPATQVESITLSFQSNGGSFSRAYSEDIISSPSIYELAISSRSDTLAVMFQGQDRAKLWQTSIERCRTEALAHEAKSGSPSPSQFNAQLAKSHAMAPGLSPDKQPHPEVLDISDVSPTKDRFAAISNEKRIIVRLNLGNSDFHIHVDLPVTYEELMMRIWWKLKLCRGRMQFDYPTVSYLDVDGREEVITPKKDLTSIFSQGPPTVLYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G164</accession>
    <name>A0A8H5G164_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G164"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000017">
        <property type="entry name" value="Oxysterol-binding protein homolog C2F12.05c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="275"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5356432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135162" checksum="A200A6C6BE122592" modified="2022-01-19" version="1">MSSSTSSKPSSTTAADTTGIAESLYQVKLLSALRSGDPALIHPFLTEIGKDRRKSVQGKENIDTGAAALHLAIRCGSVDTVRLLLSHRAISPNGIHPPGSGTTALHLAASLGRADVVNLLLEQENINDALRDSQGRSCKDVAKSKDVIRAIEDSRAFLNASYRSLLHSYIMSPSSSPPSSVLLALLESPRVRFVNLSYLDDDHGTSLLHEAAKRKDLRLIELAVRAGADVFVRDRRGKMAYDGTGKDDRVRVFLRQFANQDTTLIQNTAPSSEPPPTLKGYLNKYTNVAKGYNTRWFVLKNGILSYYRHQEDETVASRGSISMKTAILKTSAQGDRLRFEVHSTPSRGHQSVQKWYMKANHPVEASRWTQAINKSIEWYKREGASPGSSMNGTEESAGASRASGESESASGHGYASSSGNGGLSMTPSKNSTMSLPSLHSARDSISALSTLSIKRKSKQMASSSTQDSLGSSYVVYDGNDDGVSGATPKLDSDVGEEPDDGNAADEEAEEDDASYSSIDDAKSTSIPHHDSFDLHGNSMAAQMELTTQLLANTTAEMNGELKAALKESFSMVQGMMNEYIQMSKDRDTWYRKRLKVEKQRQKAWEESLAVVVKEGENLESELRVRSRKRGSRFFDEGSSFRPYEGSSTLRGKRPSMIASRSPPVVEESDLKTPMPLEDFFKTPTAQSPVDGLPLTARPPTLPQDPQILNDPVLVGSPPPLDLEDEGDTDEEDEFFDAIESNTLPNLIVPEQLTSPSHEMTVPSDMTPPYVGYKTLRDRLHIAAERPATSLWSVLKHSIGKDLTRISFPVFFNEPTSMLQRMAEDMEFSECLDVAAREKDPHRRIAFVAAFAMSNYSSTIGRIAKPFNPMLSETFEYVRFDKEYRYVSEQVSHHPPISACWAESPLWHYFGEVDAQNKFMGKSFEIRPTGVAHAELVIPQELGPDYPKAAGRFAEGKVLEHYTWKKVTTNVSGFILGSPTIDHYGDMTITNHRTGDVCVLSFKPRGWRGKDAFEISGHVRDANGNVTYEIAGRWNSQLVARKIGSGIGALHPDVSVNSPPSSPTSTQEYILLWRNSKKPAGSPFNLTPFALTLNDCPKDTLKPYLCPTDCRLRPDQRAFELGYYELANDLKQGQEEKQRSIRKAREERKLPPHRPRWFTAETDGDTGERVWTPSRVDGGTLEYWKERERVWQEKQEGHDGSARWKDVDPIFIDEPDIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G350</accession>
    <name>A0A8H5G350_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_012513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G350"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="388"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="678"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5357491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="109574" checksum="700BC3FE0B75842C" modified="2022-01-19" version="1">MTLPDSLRRAAAAGPVFLALTVENLCRSLQQLSLPDLHYIHSRIDYTVPNKQGKRLRALSIAKFVVENLAVTESSLLPAPAVHDYHAKCMFLDRRLGEGFCRMFGEKMLYTIIRSGIYDYDGPQRWLITHQATDFIKNSFESQDDLSRLVISIPVNMRVKYDDTEYHIQTQDFRGQSNSLSTILSRFFTARLKILFSLSDDDLAQVFLFYFPGTQRNSFDFEDRDTVVLKILTGIFGPITDILFDHATYDDSSDMQALRVPTFDQPDLYRLDYLQERQRWPEFVPLSTILHCLSTYRQKSVYVYPRTCGCCACDDSDYSGADVPVSQIPSLTLLKCRDPFILAHVSPERFQYVDRSLNGTLLEKKSIVQTDKGFTIYLCKDCHSSLLKSKLPVLSLVNCFYRGELPADLLALDITWAEEMVCALYHTTVLVIRLYGSVDEDQPRVLHGNASAFELNTVSTANVLPWTPNDLNGTISVVFVGPKKMTLPELRQIKQLYVRRSVVWKLLNFFFLHNRLYMNLPPPSAEILNMYPENDILPGLQERVIYDLKSDAASNFDQESSSFSEHPSAQFMKPATAESETEPFSESRQAILERHGVHDPECTKIPARSMISSALANIRTDRDRSIPDLAIHHSYSFVSEYNNPDLICGMFPTLFPLGVGGFENRDRKPYVAFDKQANYYLYYHDRSFRYHYTFLFVVFNIMQRRIAHLGVHMTTTSQSLFSVANTFASLSSQSLEKLAKRIEKEGYLQTMSPEEKLGFQLLRKVNTVAARIPGSQSAKVHTRNEIRSYFGYFGLPQLFFTFNPCAVHSPIFQVIFGDRSVNLDQMYPKLVSRYERACRIARDPVAGADFFQFSFQTAFRYLLGWDFDKRCSTEEGGIFGKIRAFYGTLEHTERGEFHGHFEIFLVGGLNPTETHAKMRIDPTFERRFCDFFDQLIWHHLPNIEYREDKNVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G6B3</accession>
    <name>A0A8H5G6B3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exocyst complex component Sec10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5359040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G6B3"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="6">
        <location>
            <begin position="77"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="5">
        <location>
            <begin position="200"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5359040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="102635" checksum="B0FF49C56EE4E800" modified="2022-01-19" version="1">MAEASRVHMEKAGNSFHSNHTLYSHLGMSRAPSLDPAVEAQLQLQSFKGKFDVTEFVGGISEKLIAESKQDAGPFDPKPFIRNFEAAVDKLIAIRKDVQAKTEQMEKSVRVSEREYSKKMADLNRGFETVGNSFSGMETKMNEVSSTAIRIGEQLETVHVERQRAQAAYDIIDFYNQFSRGDTSRLDALRKEGRQGRRQVAILLRRLNTVAKEVDLPSADKTRESIEHFCEKFEKEMLNLFDRSYRKGDPKMMHHCAQTLLEFNGGSSCIQVYVNQHDFFINSEKKHTEDSILYVHTLFSHFNLQTLLHKRWQTVPDPDKAPPKTEQGLTELFAEIRDTVGIEAQIVKAVFPNPPVVMQVFLQRVFAQSIQQHMEQLLHRGSSLSDLVYLRILQLVHVQASNLVEDLKAYELPATRTVFDTDFRKSFGGSSVVTSATSATVTTMLETTMEELFVPYTEGQRYLERESRSLGTLYTSLLINFTRYHAKVQKEGKGSVFDRVVNQLSAAAATTSTGGVSSTSAQAASAILRFGGISSTNTVEEDQVKEEDGQLSVEVAEKMLRWHAEAIGRCVELSPQNDVAKNTFALLRVLAEAISTAYMEEALETAQARLETADTKSEPNLQQMSVLRLTDLICHLWQQYVNTALLPLASSSVTIRREMVVFNNQTVSRLDGGANHLMQKLADNIVAWLSLQLTKQKRNDFKPRNDDLSFARVNTEPCVACCDLLEKVRDSAKASLSGKNLEVFLTEIGVTFHSLLLEHLRKFPVNPTGGLMLAKDIKMYQDTIASFGIPSLTERYEFIRQLGNLFLVRPDVLKSYMTENYLGRIDPTLLKPYLALRSDWGQFEKGFNDQDGSPAEDGAALETKGRFGRLSIMMKDLESLKVEGIKFSEGITVGIPTLPSGLTNGFSMANRPFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7X8</accession>
    <name>A0A8H5G7X8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_007645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7X8"/>
    <dbReference type="OrthoDB" id="2794356at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18079" checksum="884EEFD2CCD40B5A" modified="2022-01-19" version="1">MVMEVMTGQEWEIANRRSRTDAGSASSQMAYVLIEELLEAQQNYADISYDQLVSLPYLDAVCRETLRLFSPAPSVLRQQVQNPLLSSDDISIQGVPVYSATQDTVLPLSAPIKGVDGTSLLVRIWELPSIERITCIYCQRIRVHGISYIVTTNRYVQVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G875</accession>
    <name>A0A8H5G875_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_011339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G875"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5360178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="282" mass="29890" checksum="46F7FD1362866CF1" modified="2022-01-19" version="1">MTSTLRCPPTLSFDSLSRVDAAARFGFASSASQNPFPTVLVSVSGPIAPTLSQEKPNKSTLEVLVRPLSNVPGTQEKYLASILSSVLECSILGTANPRTLIQVVVQVLVPQGRYTGVGGVGIVGRDKVLASMINASTLTMLNASSIPMRGVVCAVVVGRKSKSGSTSSSSSRYVVDPADEESSSLDASGCFAFLFSDVLGKKTVNAAGSTCLWTSWRCYEGGIDEAELKEAKSVALEGAKEIWGYIRNLVGKREGLEVRMAEDVKESHEDASEQGDDDKMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAU3</accession>
    <name>A0A8H5GAU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_006130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAU3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5361518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57396" checksum="1DF03D6555D2ADDA" modified="2022-01-19" version="1">MFSSSFVPTNSILVACTCVLLAFTAHTILRRLFNPLNRFPGPALAKWNRFYMAYYDIWKGGAWIEQLQELHRLYGPVVRVAPNKLHFSDPRAYADIYSSKFTKDPDLYDRLPVSDSLLTQMDPQIYATLKPLVAPFFSRKAVLSLEGIVQSTVDTLIHQLLKNHSPTQTPANLNLALRSAAFDIITTYCFAESIDSVSYPGFHHNVLLTMDSMLPAVPLFKHFKIVKDIIVNAPLWLAPILIPSMKHAVEQFRGIEEMVERVIRDPDTAAGFSHRTIIHSLLDGAKTQSGEFATKRRPHRITKRWLVDEATTLRFAGSDTVSSACVIGCRYVLADREVLEKLVEELDDAWPDASVPAKYELLEKLPYLTGVIKESLRLSHGIVSPLPRIVGVGGATIAGHFVPEGTSAAMANSFVHLNPNVFVEPERFKPERWLQADSSSLEKYLVAFGKGPRSCIGINLAWCELYLIMGNIFRRLELAPTTDISSPYRVRDCFVPLYDDSLLHAVARERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD75</accession>
    <name>A0A8H5GD75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD75"/>
    <dbReference type="OrthoDB" id="2828670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5362748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="237" mass="25981" checksum="8CE5B5DDED6CBC02" modified="2022-01-19" version="1">MLSENSSHYLLIDILLERRYACEYQLVLVDIYLLPTLLNSWKSCTMLFMPLYMSPKSLALIPIILTLSALSVPVLTLPDPNIRRGVAGGVGGALADLGEDILGNLPDGGTKTGVHCGTTNDASLDDCKFLIQDEKNWNAAFAGNNNVCHYTNFITREFNYEAHNVACHGQCCVYVARMKTEVIKDYSSLIRQEASGLFGCADTSKGKINVMTQLDNKIGVCISNGDVWVSGLTRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDH3</accession>
    <name>A0A8H5GDH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDH3"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="8232" checksum="1C7E6A5A3B40A55D" modified="2022-01-19" version="1">MGGGGQYPYPKTVWSPAGGWWVRPSNWKTNTAVFGVFIGAAIYGIGQWTSQREVRYVKPAKQLIGTRVTQEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGG5</accession>
    <name>A0A8H5GGG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGG5"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="188" mass="20582" checksum="1BFB69BDEC5A68A4" modified="2022-01-19" version="1">MYGCSRRILVFLIGFTLIMIGVASFLAFVDNNLNSVTPFMTKEGCHAPLDATVSLQVASAWEALFVYDLVLLGFTLFKARQNAYDGTQMLGSIGGRVSLMQVLISDGSLYFVVVDLSNAINIVSFYASLSPSNYSVLTQLFMPGYFTGFQGRSNDLCELHLSLHDVKTDAKLAAGSQQRDGVEFFLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIY0</accession>
    <name>A0A8H5GIY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIY0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="115" mass="12623" checksum="BC4767AAF575FD17" modified="2022-01-19" version="1">MPGTQFAVVFWVRFADFGTPTGHLNISMLHELPATTAQLHKFYDVIFRDYPDAPPSPCKRLHTSDNDCAENPSSDTEDGHSDSDEAPSPSKKLKGVAKNTRARRSSSTKTSKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJ99</accession>
    <name>A0A8H5GJ99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJ99"/>
    <dbReference type="OrthoDB" id="5541797at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23016" checksum="10AE2A0A91912849" modified="2022-01-19" version="1">MNFRTVSRKALLTSASTARHIELQNIPSSVTPADIRRLLFRSKVKDVQDVSIIYRRFMPTGRALLALNEPSYTNDNLRALENASFAGVRIQSEAKVETAPRKNYVERIGDGPHGNTWNGGKNVFIWNLHPSTPTATIRSLLEGFELASVEDSLLKLSYSRAATSSGFLVRLSTESEAQRVVRTLHMTDLEPEKYGPAHPIRAHVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJC7</accession>
    <name>A0A8H5GJC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJC7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5365973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62397" checksum="75B61974111639DF" modified="2022-01-19" version="1">MPSTVHLLAIPVLLIVYNLGKYLLRRHLQTLSYPPGPGRLPIIGSFFDVLAPRTGLETQWAIYRDMGHEYHSDILHIDILGDHTVVLNSAKAAEELLEKRSGIYSSRPTMYMANESGWGWNFVTMPYTSWWRLHRRTFHQHFRSDAVAAYHPFIRQATSRFLRSLSGIQSTTMVTQYNDLQAIVRQHAASIILYTTYGITEQEDMDAFVELVNNAAESMIATINHGNFLVDYFPLLRYVPAWFPGAHFKRKAVHWSQFTSDLVNKPWKQLRASISSGTAVSCFGTKSLQKLDLTFNAADATEDTSDLGMSKTDSDTKMEEVIRNCAGSAYLAGSDTSVSLVLISVLVLSHHPEIQAKAQEELDRVLGSTANATQLPDFSDRESLPYVEAVFKELLRMYPSAPLGVPHYSVADDVYDGYFIPKGKAILHDENLYPDPLTFNPDRFLRTEPQRGAPCAKHSLNPDPELYAFGFGRRICPGRHLALDTSWLVLACLLATCNISRISSDNTDPKSKEIDPIADFADGVVVHPKPFKSCISPRSAGAFELMKSGYEVGIEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL97</accession>
    <name>A0A8H5GL97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL97"/>
    <dbReference type="OrthoDB" id="2422225at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5367007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="891" mass="99856" checksum="CCA284291E9E512A" modified="2022-01-19" version="1">MSISPSPFPAAPLSSGLTNAACWSPTSHLLASTSRQSPSWLMDILQAQTMCNTSGYPVEEISFQTRAAIRKSAESLLRYLHVSDAQRQALEDIYCNSEQTVLNFDDSNQDKARDKLAELGSDRVGREDLSSRWSFTIAMQSTSMSKIESFARKIPHTPSLNARRVFISFLIPTLAALYTLRYWNVKTATYSEYPASLSIMKSAASLAILQLVKGATLTAIQRTNQEMISKKQYRGLRGDQSKANFHYIILSSDNITLYRKHALLYGIDIRLAPQYNIDNWINTPLGSLPTKIQAQIREAIFYYQAQAERGDQIKVCIATLEMDKAVMNERILMFIAMGIDENRKGLPIAIFLFSAPLGAQATHANYDREILYELLKSWKDHLEKKFSTAFTPTCIITDTDVCKQNALICLWANIILLLCKFHVTQCWTNSRKAKVTGKQEDVIKADIVKRLKSLEQRLLEMVKHEDAMLLIHQEQVYFRTLQTQKPGNKTIKGALLHIMYLLDNWMLEATWKSWSAYGRKQAAAVLAVEPEDVLTTTNHLERFNGILKGKEIGAWLHSGRCLCFNRRGYQDWLGARFREAAGGGDVFEMKKALQEERRARREAEKRYCYWEPDSLRDNGTKAILTSHAFRNTIRLGEDGNLIQGFCRSSSGDLIYTVELRRIGTGSCSCMEFSSRGGACKHLHALRHVAFFYLRQQNQAPFFFPSSEVEAMGAKRLASSAAVETVEDETDNIDNTDWTALQQAAADDTTLGDELDEKEGTASIGVEVVEDEDSGGDVGFTAEDQQEAINGQVTNSIKYHIASASKPLQGIKNLVSELAFLPQDETIEEFQDLIQDISNSFHALRLQHSPPSPTQTCTASNASSPSNSPPRQTTSMPTTPERGPALGYPTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLP9</accession>
    <name>A0A8H5GLP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_004019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLP9"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="35"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5367034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="42703" checksum="A30E21C91427FF82" modified="2022-01-19" version="1">MLTRTLTSSFRRQFSSSSIAYNRALVYSRNGSPSEVLSAITYPDLPPPPPNTVNIRFILSAINPADINTIEGVYPSKPTLTSNINSTGPGSDEQPVFVAGNEGLAQIDQIGDGVEGFKQNDWVVMDKSQVGTWSTCRNVSAKDVIRLPLKDSDGLTAPHGATMTVNPTTAFNMLREFVDLKEGDWVVQNGANSAVGKLVIQIAKLRGLNTLNLVRARDNFAEFAKSLEDLGATKVLTYDDLKDKAVRGKIQEWTSGKPLLLALNCIGGDATTSMVKLLSNGAHLVSYGAMSKQPISLPTSLFIFKDLMTHGFWQTRWSKTHSREEKEELIGKLAGWMSRGQLQAPEHEIITLGKNETDEEVSQRVRGIFSDMAEGKYKKKVLLKLEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM43</accession>
    <name>A0A8H5GM43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM43"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="267" mass="29453" checksum="D69971D7C493C22D" modified="2022-01-19" version="1">MDLKELDALVHFLQVHSIEESTKSNYATGAHDYICFCTSHNLPLDPTLSTLSCYVAFTSRHIASAPKYLTGACHYLKDIYPYFDESRSSPLVPFVAPKRFVVMLFTTSHLSLPPTSKVLLTKQNKPSITMTSSLPQSLPVLSMPAITLRSSLRFEDSHAAYHLPYHKADPFYCGTDILLTSQTVGNPVQLLQDYADARDRLYGARAALFIREDGSLPTRAWFDSKFFAVVGKEFGGHSARAGGATFYAGLGLSESIIQALGRWSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM71</accession>
    <name>A0A8H5GM71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM71"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="619"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="765" mass="86690" checksum="DFD2E4D5D33BE4A1" modified="2022-01-19" version="1">MTNLLAIPSKKTYTIDIKQPVYDYLLEHGGTHPAAVKQDISQWQALRQRLVGGEPHLDLVQDMLRYHAHLTTILSKLPTDIGLEIAYAPAFSPSALPVTLKNLVFERASLCFNIAALYSQLAASEDRSQVDGIKRAVMHFQNASGTLHYLRTSVLPKLVFSPDDEQKPLDLSAASVHGLEWLMLAQAQEYDRTKNSVIARLASSASSFEQFHCCSEAFNNAEKDWLAHIETKQYHFEAVSQYRKSRDELNDSRYGSEIGYLTQALARAKKAHDIARKGKVANAVQHDVQSFLEAVQKNITRAERDNDLIYHQDVPPASSLSPIMQGTVVQMTIPKELATPTTIVNSNDMLFTELISWGARAAINIYIDRRKNLIQDQLVEAAQASKDEAERVLRSMNLPASLDALERHVGLPPSLLKKAEEVRLENGPVKIEAAIDAVQKLARQNLKTLDEAMDILDHEASEDESTRENVDIDRPPSHEANKHLIEMYNRYRAILDQAAASDETVRTKWDQWERNITELTWDEADLEGSIPSSTASSRNAETDRHARVLHALLEQLDELHVNREQVVSRAQKLAEVDDIQPRIIKAATGLEKLGELQPAMFEDILDQELAKYDKFISWLKDLESKQQEILQSITKENEAFLHSRKDDESVKNRERALQSLELSYQKYKEITRNLEEGLRFYNDLIGILIQFKETCREWSNERQREIHSLSRSMHSLSVGQKHEPTDSLPIRKAGEAPTTLPGLNSSEWCFEEMSLPPPPPSGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN44</accession>
    <name>A0A8H5GN44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN44"/>
    <dbReference type="OrthoDB" id="3341077at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="35016" checksum="C4D0FF819DEC5A7F" modified="2022-01-19" version="1">MSYLQSIYDSIYVPSLLTHVLYGGYAVLFAIFMYIMRCKNGITQRVHQVAIISLFALATVGFIFSSIEENMQVKLKSGPGLESFKDWFNPYLISQTVLFGIYTLANVIADFILIHRCYKLWKSKKRVIAFPVFISVVNNGLALVRMIFQAIWAKDMITDDFETLDSDTLSSIGKLGPDFLISFLAVNLFANLLIPFMIAGRIWWIGRQASKFIGRRKNSLTRRSITAICLESGIIYPVLLIPTLAVYVPIYTSTASFNFLGDLIPMLTQVVGIAPTFIIVRVALGISIENVQDTAASWDNEGDLEDDASTGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ82</accession>
    <name>A0A8H5GQ82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ82"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="544" mass="58991" checksum="CDC6D214279F6768" modified="2022-01-19" version="1">MDTFRFRSGNPWTQSVKAASYLPSHDVTTEEGNLRPPPPVACSLGPFGSQTRVEMNMFQTLKMACSYKQYLAVAPFPSASHSPEIGIRVTRPSPACIQIWSFSPTSTASTVDDAAQAPTFSSGADPGQMKCEMIVCIDSGPAHELKWCPLPSNSSLSQDSETPRKLGLLSGTFEDGSFSVFVIPLPEDVTPPGYDGKEPVVVKIPDPILRIELEEACCWALDWANSEVIAVGTTNGQSFRVVAVYDIGNALKQVKETLAEPITDLLPTHYLTLHQSAIRALSWIRAPPSYPSGKPRIDENPTVIASGGYDGIECLADIREGRGSVMNRTRDVINTMAYPTFGGGPVTIDHENIVKAYSVSPRMLGRGHMLMEPQGPVWSVSACDYHPQLAVGAADGTCTTTNMLRSTRRGGSVPFFVHKIYHLDYSRSLKESRILERFLPQETQDRPTARSGQKHREAGKTTAGSTGVWPREVGVQKVSWNSGNGPAASGMLASATALGLCRVDVLWGRWMKDKQPYGGILGIRIEGEDDVDIEGDSNGSAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ84</accession>
    <name>A0A8H5GQ84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ84"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="124" mass="14021" checksum="1C9F3339CA411AC3" modified="2022-01-19" version="1">MQIEYPAWRPSSSLTSPHNSHHASHLASQQGSKILLSQLPFDENQKAWRSYVFRGHVYYGKFVDGRRPIKIEIMTPSSSSSRICTSYSSSYSSSFTPLNVTPNPNSTLTTSQSTCWRYKKDPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQU0</accession>
    <name>A0A8H5GQU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQU0"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="220"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5369514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34061" checksum="2E277C8666348A5B" modified="2022-01-19" version="1">MPESPSKSSRPFVIPQFTPRDYGSFFMAGALCATISHGGMTPIDVVKTRIQVDPAFKNLGFITGTRHIITKEGASALLTGFGPTAVGYLIQGGAKFAGYEFWKKQFVEIAGDQETAVKYRTAIYLGAASVGEFFADILLTPLEATRIRLVSERGFATGLVSGFTRLAREGGVREMYSGFLPILCKQIPYAIGQFTVNELCHELVYRSMTEETKKNLSASANLTISLGSGITAGFAAAILSQPADTLLSQINKGHGPKGSMSYRLITLAREAGFRGLFAGLGPRMIMTAGLVASQFIMYDSIKHALGAPPGLEIHKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS13</accession>
    <name>A0A8H5GS13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_001381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS13"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5370062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="479" mass="51557" checksum="19D6F2D728388ACA" modified="2022-01-19" version="1">MSDASYQPIPQAPVPSNLLVSSDSDDYEQQEDSISRSPIPVDSRIRWINFMLGCAVLLPWNALITATPYFLSRLADSPFKSTFNSYLSTTFTAANFIFLARATVTSKQLSPSRVTIVSLIVLAGLNVLLTLSTVLTLTPGVFFAFVILNGIAQASFGSYLQNSLMAVASLFGHTAVQSLLSGQAAVAVVVSTVQVLSSIASVSHDASPMEDSSSDGKAEERAAFMFFGLSTLFLLASAGAQWYLVSMPEYQAVAGSLEPRKTVGRDHGDADENRSLVSGDYSSDEKARIWEVAKKNMSFEFAVGYVFVVTLAVFPPITATIQPTNPNVHPLLFTSVHFLMFGLGDFVGRSLCSIPRLWTWSARKLVTMSLSRTLFIILFLLSNVQRPSSSPIPSAPIINSDLLFMLILFAFGVSNGYVSTMGLMSASSLEHNPRLKGRVELVDVAATVSQFCLVGGLVLGSIASFPVRGAVCACNPFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSB2</accession>
    <name>A0A8H5GSB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSB2"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5370082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="266" mass="30532" checksum="7E62232CF87013AF" modified="2022-01-19" version="1">MQTRAEILFIAELAGEAERYDDVISQIKLICDRFGGRLTGDERNLLSVAYKNSTNNLRASWRIVDTLEKVQAARPSSTMKQLHLLRKQRNRIGQELSDVCKDIIHLLDDQLLPFAKQGEERVFYSKMKGDYFRYMSEFAQDKDNRDQYAEESLGAYKQAYKEALYNLDPVHPTRLGLALNFAVFYHGMPLFFVDGVKLLTLHPAPDVQKSPTRACHLAKNAFDDAVLTMHPPDADPEAAQLRDSLQILQLLRDDLILWSKELQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSG1</accession>
    <name>A0A8H5GSG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_006967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSG1"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="307"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="755"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="852" mass="96783" checksum="76F14BD040C6B97C" modified="2022-01-19" version="1">MISHVIAFDSPVAKVYDTLPPPPEDLDEVLAIMFTGPCKPTEKDFQRTPMLIRRKYVYDALTWLKLNHPAYQELNISTANLNKYSEKTPYVSVEYKPSTSEGNRVPEGTSVHDNEPEIGTEDGEVPFVVHGITGERLQNETAESQKAKALAHLNSQGKFLAVGHSKDSSTIFKNPELYPSIFPWLFPYGLGGLGMNDIPRFSEKAHKKFLLNYHDKRFQTDITFPFVAFSHEQIKATTHNGFAMTELQSFPVIADRILGVDHTVLTNIINRLEQGEIVHPKTEAEKTCFSIIQDLDHVGGGVKGSMTSAPSWYITFAPSDTTHPLCLYYAGSNEKFEPYLNIPDDERTRQVIRNPVSGAKFFDFMVEMFIKAILGVDSDHDGVFGKTSAYYGTVEQQGRLTLHLHLLLWIASAKSPQEIRDAILDPNSDFQKRIVEYLEKAHTAEQYDANELFEAETTLSDSDLDDIESDTEAELQENEYSQCPKPLERADLPKNMFPFLAGHPLADSRVLKVASERQRLVPNFIGGVLPRADCGSREYYCCVMLTFFKPWRSGESLKDMDQSWDSTFENFEFSPRQKEVSKNFQVRYECLDARDDYNAQRKTMSGDTDNIHIPEYDDGLDCDILDVSADPLINGESGPLEKRRQEHMNEMKDMLTGMGWNETLHDRRLHIPAEFNPETDRSAHSWRLQINKMRQAILDERHKPKNSSNNNSKFPNKFPNQVEILDKTAFEKNTRKGQTQDLIDQIAREFQFENNIEQDRAFRIIANHAVSPCPQQLKMYIGGMGGTGKSTVLRALRKFFAERNESYRMLVVAPTGNAAALLAGSTYHYMFGINSKSEGEFHSTSMSQICSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV19</accession>
    <name>A0A8H5GV19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_003590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV19"/>
    <dbReference type="OrthoDB" id="3258172at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029146">
        <property type="entry name" value="Ten1_animal_plant"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15490">
        <property type="entry name" value="Ten1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="136" mass="14681" checksum="E5D2D75627A97454" modified="2022-01-19" version="1">MAPQPDSATPTAIYSVKNPALIGQKLRVAGRMMSYSDENGFIILEHKNAAVLVDVSLIIGPKSAWVNETYTTIMVAGYLDKSEDALPLPELPPYATAPDIDPHLVLNAILAVPVVDLDMDLWHGAIEELGKKISSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GY52</accession>
    <name>A0A8H5GY52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_001638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GY52"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="128"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="680" mass="72776" checksum="280D8B612D4985EB" modified="2022-01-19" version="1">MNWLSSLFSSSSVPTRKGQAISNTHEAFSIPTSSPTFGPSHPDAFNPDTLNTPDTAAYSYPPQSPVTYNYSSRSSSRPASLLPTHVDPSLRPPMLSPSSYPPLATTWNRLRLWLNREYPELGDTLNYGILPQDLAQIEMQFGFGLPTVVRESYLIVDGQEAESAAGCSEGLFFGLTFLPLDDVLDEWRFWREVDDDPTTGANPQLRDAMQSLPPRWIRQEYSQRGWIPLIADKAGNYIGVDLNPGEDGTSGQVIIFGRDFDTKVVLFHGDGPAGWAKWLAAFVEDLETGEGFEIGNTDDNEGSEDDIGYESYFHDGTGGGQGDGGGDSGSGGGLRLIGEYKGWNVLEAWADRSVRKWYEAGVITEDVDQEKKAHQEELSISALDLNQDSAAEVAIPVLADVEDDTETAMLTTPTTPSARKSPANLPTISVTKPPAPLPVELPTPRDIVALPSPPDSNHSSFDEERESTGIRGRQRPRDIEEGLYTPNTDASSSAAASGSKSSTSTLSKRMSPPDLLEGDSEVLETTPIIHSTTLSSSGSSSTQISSSSSREDSLVDVDSAEDAGNTTLTDGAGSGVQTASDPDVTIRLVGGGGSSGLISEEAEEDETQEFEIGSETDGDAASIASEAADADAPADSKVDVKKHKHKKSKSLASLKKLVGKKKDTEKATTAGNEQESESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ92</accession>
    <name>A0A8H5GZ92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_000723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ92"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="5">
        <location>
            <begin position="127"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5373724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="446" mass="49576" checksum="C8EF32F5DDB0194A" modified="2022-01-19" version="1">MELSVPTQSAPKTFDELRKLLEKDIKVKVAGIDVDGILRGKFMSKDKFLSVASSDGFGFCSVIFGWDMHDTVYSRELLISNKANGYRDILASIDLSTYRRIPWENDVPFFLVSFLDPDTKEPLVVDPRGILRITGERAAAKELTCIAGVEYEYFNFKETPTSLTDKKFHNLDPLTPALNNDYFHDIFDEGLKFGIDIEGHHTETGPGVLETALAYTKALRVADNAILFKYLTKSLGMKHGVIPSFMAKPWGNLPGCSGHIHVSLCDKNGRNIFALSEPELSNGRAGAANDDTKFMSEEGEQFLAGLVPTINGYKRLVGGEAFWAPNAVTYGYDSRSASIRIISPPSVPPAATRLEIRVPGADMNPYFALSAAFLLGLRGIEKKLKLTTPPMKSATERMMKPNSIAREKGMFGDVFVEHYGGTREHEVKLWNEAVTNWEVERYIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZX1</accession>
    <name>A0A8H5GZX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZX1"/>
    <dbReference type="OrthoDB" id="3252971at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="58040" checksum="80C4FA21A8F47AE0" modified="2022-01-19" version="1">MADVYFTSTDGVTYTRRLYGRERMSAAATRHSDGLGQIVTMGEVELKSYLTQEKLAPYVKAAWTSLRFTVPWMAVLTTDIDPTDNSFLFTYKVPLDQDEIDAWTDKTIVWRTEELSFSEWEEVVKRTHWKPGDNRYGFEVHISLTTDGYWMMGLTAPHWVTDGRGILPVFDQFFKCLQAQFDGSAPPVNSIRWGEEVIRLPPTGVRIVPDVGPIPVSMDPPPAQFTRLSRKANEVDPNVESINRCIVLTKEQTEAFNLACKRHRCSITAAINSIFLLADLETELRCAADSKGDDWDQLLDSFHQADLFSLPFNVSDVRHFIYPLFTKISQPCGVGGLINCGFATYHDMNNIRNCLHVGKDGDIVKNYGPQSFWDGVVMDTRNVLREAVKTKATAKMYHHLSATAEAAAASVRGCQVPWPGVMASSLGSLDKLSLFTRFRPSVSKSDPGTAFSVRQWRFGIRTAWLCAIAINTWEYDGVLSLNLQGSSRWQTQQSWDYFSNAVTDAFERITSATSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0G4</accession>
    <name>A0A8H5H0G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1361" mass="147228" checksum="5154BF587B9B703E" modified="2022-01-19" version="1">MDQNDIESTHIDAVKNLRSRFEQLAHHDSSPPSASPIASHRLSTMSTLSTLSTMSALSSTSSLQVPSPTTPTRVRTLSKGSDDNPPSSATNSRHLRTASSSSDIKVSARRPPPPPPPHAQSSSRSPSPSPSQTSPRGSPLLRPVSSTSSLRQFSSRPSIVPLVTANNDSDETIDPETPTPSVAALRNKFLITSPSLSSPALMPTIGKLNMNGFHSHSDTTLQTYSHQSPPTVNKPPPPVPSRPIKPAVMPAEGAPPLIPELVSSPEEVHSHTQSFHSSSFSSIDPSDPFGDSSSGSEESSGFSNFKPPALPARRGTNTSSHRPSLSSSSSRTSSESDGVSSNPTYILSPASKFPIPPPRPPPRHSEASILSPVTPTGPALPSRPPLPARRNTSTHSDELIGAPPKLPQRQGTTVAGVPPPPPLATHPSLAGQHSQFPATPATSVGMGAATIYPTDSSASASTSALLGERKALGASKLLPPPTRTIALGDKLPPARKDEPADDSDMDSGEDDDEGASTSKTSIVMDPDTTRVSRRPPFLLARTGGLSGNFESYGCIGRPEWSPRIVAPGECVFTNNWIVVALEGGHGSGVAIYDIGYSLDRPRFLVSTKQVGVKDGKVTAMEVRGSGVTLSSPSLTSPTDAKGKGKQLERGCFVWIGTKDGHLVEIDCRTGDITGVKHSAHIHPIVHIFRHGASMVSVDDSGKVLIFSPPPDSSTEAIETGEVRLLLTTPRVMRITDKLDFCILLGGCLWTGARSEQHTHGTGPAGKTPIIRVYDVFTPGSIGKSVMPYQHVGAATCAAILPTRPGYVYVGHEEGYITIWDVGGGPLSKSEFSEDNKTGSYAQPHCVELLKLQVNDVLALQGVNNRLWVGNRAGYITVYDVGVNPWFATNSWPAHMGLPVGKIMVDPWGIERLGRLGVVTVGRDNKIGLWDGLLAADWLDNKLVYAEAEYSRLRDLKVLMVSWNCDASKPDALLSAGGEANLNFLSDVLRSVDSPDIITFGFQEIIDLESRKLAAKTVVYGRNNETSSKKKDGPYVKGSLWEYKDTDEAAGSNSNSLGLWDKVSSVYRKWYDQLVLAVRLAMPPDQPYSVVYTQSMVGLFSCIFVKQAERSSVRNLGVTSIKRGMGGRYGNKGAIVLRFVFQDTSICFLNCHLAAGQSATRSRNNDIAGILESQQVFNPAHEPLAFLGGGDGSMIMDHEIVFINGDLNYRIDLPRKNIIASVRAGDLDSLLPHDQLRKNMRDNRGCRFRAFTEGPLKFAPTYKYDRRSNEYDSSEKSRAPAWCDRILWRSKVPERVQQLFYKRHEVNVSDHRPISSAFTIQVKTVKEDARQKVKAEIQMKWIETQRNLLAAARDFYVSHMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1X1</accession>
    <name>A0A8H5H1X1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1X1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5375100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="366" mass="40855" checksum="A3E845314D8E3B36" modified="2022-01-19" version="1">MSAEFDDVLTNQPVVIDNGSGTIKAGFAGQDHPKCFFPSFVGRPKHVRVMAGALEGETFIGRRAQEFRGLLKIKYPMEHGIVTDWDDMERIWSWHPVLLTEAPLNPRSNRDIAAQIFFDTFNVPALFTSVQAVLSLYSSGRTTGIVLDSGDGVTHAVPVFEGFSMPHAIRRVDIAGRDVTDQLQLLLRKSGHHLHTTAEREIVRTIKEKCCYVALNPSKEEKESAGHLEEFRLPDGNVVQLGAERFRAPEILFNPELIGQEYAGVHQVVVDSINRVDLDLRKSLFSNIVLSGGSTLCRGFGDRLLNEVKKLALKDVKIKIYAPPERKYSTWIGGSILAGLNAFKKMWVSAEEYQEDPDIIHKKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H2A8</accession>
    <name>A0A8H5H2A8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H2A8"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5375280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="23312" checksum="4E0C7EEAB9808B5E" modified="2022-01-19" version="1">MPSPAPPGSYADFEFFDPSLSHLFPNPPHLPPSSELFSAQEQNHLFDFLDGFADPALDGSPPPPPQGEYYYASSESSTTPPHAFHPDPSPPPPPQPQSRCSPIAASRTKPLLSTPQKRLNHIMSEQKRRNAIRDGYAQLISLLAPAGCTVAIDMPSRGRPKGSGSRGKGTSKGKSGVLFRAVEYCQWLEEGRDALQKEVSRLEAMACLNHPQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LGE1</accession>
    <name>A0A8H5LGE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LGE1"/>
    <dbReference type="OrthoDB" id="2953266at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="43062" checksum="619EADDEC97A2168" modified="2022-01-19" version="1">MGFFFQVFKADCPVQFFRVKDLQTFQLRGFNDSTYNPSVIFHDGRSFAFPSPDRDPNLIKHPYRPGSSTATSRSEQRLFTAADLLSYLPDSSESESQSGGVRSAQDPHVWVSPQTGMICLGAEGPSLEVGSGSLRFDRVQLTKVSFPASDLIPQNNCNDCGLLNYILQNIASKTVLTVLSDSHFLYTSIPLNIATRRFNFALAPRLLSPIYLVAAGILAMVVSTCVLQMTGLMEWLWRMEESASQSLLTSASFALHFGQTAFHGKTGRIAPSFRITFASASDPRNPVLSTAKFLARYLTLRYSDNITRATFSYIRYLEFLTVSRIWTSGNGEEAKGFDPYSLDFTRSLGYAEVQIVHPEESRFETVVDDEGMCNLQASGIDVEYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIP0</accession>
    <name>A0A8H5LIP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIP0"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="555"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5358657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="774" mass="87763" checksum="520204279A43D57D" modified="2022-01-19" version="1">MIPAGQPQFYYSPNPQTMPPLVGGMQTFPPNYIPGMQTPQYRPRRRRHRRRNDSADTISSDSDKESVQPEYEDTIEPHEHYTVRFQKWHTKKNIYVPFDPRNWKAEPVVEKDTDTYFFVNSRHMMPGVVPQLYLSDWSDPLLYFLRSSVGGNFFQPNPERILEEFFPEVERMKISLENVRNALKPDSKLKLDEKVELAKSIGRSEAALSQEDELMKQFSDLAKHLEILLSYVTEKRQPLLDRLALIITYGQMEFDLLQYFFKKDDVLVTTTDDSSLDPPVAFKVISSKYDRSTSAFLIAGENYEWSGYAYISRRISRRCIRFSGTKDISALPFVHLTPEVKETLIARGKLYTTYSGVHFMSYYNNRVMIDRIGWNTHSGLGSWAPPPPSPGLEPAPANNGDPWGSPPEQWNGPNTPQWGMNNSPGGNYDDPQFPNQAPPGQWGQAPMNPATNGKCSPEIERFVFRPKSGKEVPTIDDEMLCFLPADVYGFDLGTKQWITMSIEKLKPVTFDEGAWDHLVLDDRVKTLIKGLVEVTRKQNDMSDLLIKDVIKGKGGGLVCVLHGPPGTGKTLTAEAVAELLRRPLYIAGSTELTTDPTQLESKLSHILNLAMAWDAVVLVDEADVFLEQRSLHELERNSLVSAVLRLLEYHRGVLFLTTNRIKAFDHAFMSRISIAIKYPELDHAGRYSVWSKFFALAGYEVKESSDPFAGPNTFLRVDVEELASKPFNGRTIKNLVRTAQALALSTNSPLKLEHVHVVVSAQEKFLDEFAGMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIW0</accession>
    <name>A0A8H5LIW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIW0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5358749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62960" checksum="D16BBF9F2A184715" modified="2022-01-19" version="1">MLRTENVFETLLLWVTVLLCFSSCRRDFLSRMPKVKKPQSLLKLQGQLGYKLLIWVALANLLACKSVSQAELRLPMQHHAKVLSRPLPRYWKSKVEIVVCEMASSGFLSIIGDRITLCEKGKEILLNALPSHDPQDLLIQKHWDHFVATVCRPIPQLPTELLLLVASQCDTINCLKAGRLVCKNWLAPMSEELHQRGMCKLSWSALRQLVKEFDKTQQHNYFIHFRNLSAHLPLCMRPIHNLLDISFTRLESLELSGFANSAEAIALVGNVEFQTLSHLSFRNLSGPVAAWVKLLQGVNPRKLKKLTCDLCIVYPLTPDNLPVVVPNRLEFDDLVLSLNYSGGLIRVLQYFSVTGVSSLLFTQNGVLGDELVEFINQQAQSLKLLAWHAFIESKHATIHTIQLVLNKHIDGLDIEFRAMHKLQHLSMHGTEFRPWVPLPVRLKAVSELMAHTPHLCELSLPLEPTDGRECQSLDDALILLVEHKALQRITIYPSYHLDVMEPDTNALAGFLPKMWGVSSDKMRSCFASVIHNELIGRVTGVHSADVFGSPLGTAFIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LJU5</accession>
    <name>A0A8H5LJU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LJU5"/>
    <dbReference type="OrthoDB" id="3259646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5360185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="263" mass="28491" checksum="F1AB44007B177D72" modified="2022-01-19" version="1">MLGVQSVELVISVESQRKVEELSNSAAQLIEQFKESGDCVAIDSAVQLMEEAINLTPDGHPDKGTLLSNLGIALWVRFEHLRELGDIERAAHFIQKAVDLTPDDHASKANQLSNLGFAFQSRSEHLGELEDIGNAIHIYQQAVDLTPDGHADKATELNNLGHAFQSLGELGDIENAICFNQQAVDLTPDGHTYKAVRLSNLGTAFLGELGDIEKAIHFNQQAVDLMPDGHASKGTGLNNLGTALLESRGTSRMLFTSSSRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LK00</accession>
    <name>A0A8H5LK00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_011368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034401315" description="Chitinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="12">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="213"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="808"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5360156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1355" mass="143817" checksum="665DAF493C62FFED" modified="2022-01-19" version="1">MYRSQLQLPLLSVAFILLNIAYGVFGADCKTATVGQPFSTCFDIFTNAGITADQFASFNPGIDCSLIQPGQKVCVSSGTLPSNAPPPNQNGTCAMYTTIPEDSCSKIAIKFDITVAHIEEWNQNTFKWKGCASLQRDFTMCVSPGDPPPIPIIPGLQCGPQSEGNASCPLHACCSAFGFCGLTDQFCTTAEPNPCISNCFTPTIPSCGAGRSIRKMGYYAGWGDRRACGTNVAPNQINWDGFTHVNFAFGSISQGLEIQLSDADVPLLQQLVNQKASNPGMKVIIAIGGWDFSELDATKDLFSFMIASSSSRATFINSVKSFLDRFELDGIDIDFEYPGAIERNAPATDTPNLTAFFKELRSAIGSKIISIATPAGYWFLKGFEIDKIAGSVDYMNMMSYDFHGPWDTNVTDQAPVSNPHTSMLDIQDAARLYVRAGVDLGKVNLGLAYYGRSYQLADASCSGYNCTMLGGGFPGDCTQASGILAQFEIEDLLQSGIQATHDSKTETYWFDTQGSLVTFDQQDTWNVKQQFAETSCFGGTFAWSLDQRTDDLTDGSGSGSGGSKPGQYSTVEWNPNPFPSPNAHSQTFAQSAGTVTSAVTTVVGATTSTVTSTVVIPAETSTTTSWAVLSGTPSSAVGTTVVPASTATITRTVTTGSTAVSTTILTNTATTVIVPVPSSTSSVTIGGVIITLNSGGTPVNGPVPTWISQPNAITPTWTFNILPPTDANTVTFTAPLTSTPTWTSTVKTSQSSSTSSGAFVVVTGPPGDHSRCNPSINIFSLIFGGGISGCLPADVGIINGITPSPIKPPGWTGPWTDPFPLPTEPPGPGDDPDDPDHSSTTTSTTSTSSDSTCHAVPTSGYSLPGDPENADWEGLGTDPNSRRKRSNSRVVSKSVQQDIHARDGRHIAVNRCSLQKASPNDVRLGAGQYVRIARSSTSLGLNVGVIQVGAKPAPGAGDSVIQEHIFELGYINQFFKDSVMSQAPCNWISDNIFDYTRADGSEMGAGLVAAIDTQRNMVWADVAMNQAKSNVVNQNRNTAANPPQKESMEIIGDFEDDDDLIYDVEWFIRNLGGLGSYFAATSNIFQQTALDVQNLLSEITPNSVVVQTDSLPAIFNSWLRGLISTYPAGCTSRATNANAFYRRQMQQVALINNPQNPQVPRCFPLFTANNFNPTSFTAGNLIPPAPTTPRCNVPGTTGKVVFITSGSSNEQDIDQLLTQRVMGSGNTNFYAIGSGNTIRDSHWQAFDANQAFQTNDANCNGVFILLDTASGQINIPSTSANIDFTCNGGLVGKGRSDFNFFINGQRMGCAVLITGHAGGTTQQFYCAAQQSKAVACASSPSGVGGQAVTMRFVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLA0</accession>
    <name>A0A8H5LLA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLA0"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57029" checksum="C9DB6A75C8420FBC" modified="2022-01-19" version="1">MLEPDHNHAPHPESPVVSPHLSPSPVSVDPMHITPNDRKTTKFRLTTKLGYGLEPIQSSGQHEVPEPTPEPEHPLSPVKPQSPLRRSPSDSTPSAIQEPISIPPHRIIDLQNILSNLGMSEHNKPASATAAAGGTNRPPADADILSDNDQLPNKTTKERGSKLDKFTGEQNLVKDWLAEFNNYIRLNKGVYPTENEKIALFLTLFTGERAGRWAHNMMAKIYEEDNDLSDSDEEYWSTNKDSSLGSKKKKKWTLREVKQQFLHDFKPTSRKTQAQAKIEVIRMEGALADIDKYNSKFESYAKDTGYNNEALMKYYRKGLPRGLADRISYLPSQPKNLETLQRAAVKQHMTWVERQTEKVLWSKQRGEGERQTKGSQKTGGSRMRSMEVNAFQNNNPGASPKVKYLPKLTNEERERMKKEGRCFGCHGLGHTTFNCPTFPRSSMSNSDNTTRKPSIRATTTKPSPLGTNTTMKEIAEEFTAKVRVLSGEEREKATGYLKDLITESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPY2</accession>
    <name>A0A8H5LPY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPY2"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="583" mass="64690" checksum="88C17E8BEDEF2391" modified="2022-01-19" version="1">MMIKSITFYAFSFPGDTTLLDAFLGAGKPIPIPEVDAAACYWDVVMNPTPGIDLDIAFGTEITRRREELFRTERIEERCISAKEAEIQIRAKVSCLLSLGTEEHLLQALGVRSAEGSVDVDKAKSVLIRLRRALEEEALRMERPYECEDELRQRFLENGVSVCERIVAIAMRYEQAEHFTNTTITTVDLDSTAMHSEQEDSSSLSSSSSFSTATTTSTTSTFGDTDSSSKAFRCYPNKDNTETGLFSPKSRSWRRIRQASCKMLGRLDCHCRPKLQPKGPTKMDSLPLDTSHPAVRDYLALIRLQVLTPLSLLINIATVIVCSVLVSPSISGISTRHPTSISPRPMVIAVYVAALYIGQIGYCVLLVLARKMETKRTLIKGVGLSLVLANWVMALWAIAWVFEWFLTAIILQGILLLLLLYSNIVLLIYHKPTSQRPFDTLLIHAPMRFFLVLEIAMMFPLGLFIELGLTDGIPVGGAPTHRANPWPAFGVVLGTNFIGMLVVIMRRDIVWCVAATWICISIWSLKPKPAPVFQRREGRVALPGDGTEHPGLYNRNSTRGQARVDGNANAGPREVDAEAVWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRB9</accession>
    <name>A0A8H5LRB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_008987</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRB9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5366564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="66979" checksum="B287233F5ED06902" modified="2022-01-19" version="1">MVVSFNGVVSYSPVPNLRFYSFRNNPYNDCTAGSESITAAVGRHTCLSVLFLEERLDSHLLDDKDTLFEGNASAFRVMSYRFIIHTKDNYQRTFVFALLVAVLLVSAKVWRVLFFTRFPVDKYGNSIPPGPVGLPILDYWAKRFGPIYSLWLGNQLFMMISDPQIVKDLMVTNGAIFSSRKEMFLKNQTIFAGRGITVTPYNNRWRKHRRLAMTALNPRAVDGYAHVLDYEATVLIKELLMYGKDGGVPINPQPHIGRCSLNVMLTVTFGLRTDSIDNPLVAKALRLSREFMNCTGPVSNMTDFVPLLQRLPNCMVERGKRLHRELVETYGGMVDDIATRIKDGEHVPDCLVTNLLQVKDEEELDYLDMSMLCSAFMIAAIMQWFSALIPAHPEIQEKAHQELDNVVGRSRLPTMDDEKNLPYIRAIIKEVERCHNPFWLGNPHVSTQDFTYRGQFIPKDTVLILNTYTMHHDHQRHPDPFKFNPDRYLNDSTLSSESANLPNVMERDHWMFGIGRRICPGIWVAEREIFLVIVRMLWAFRMEEIPDEPIDLKEYDGLSGRSPVPFRIQMIPRHAKVAQVLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRM2</accession>
    <name>A0A8H5LRM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRM2"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45612" checksum="4C2F93296E355AA9" modified="2022-01-19" version="1">MNQLGNLKTSFHENIGSSRVDICVYHGHTWYSSARIKKRIAARFIFQQHLSPTWKMMTAWLCSVVGRPHQASIMARAGNKDSFVGDEAQAKRGILNLSYPIDRGIVTNWDEIEKIWHHTFHNELHVAPEEHPVLLTEAPLNPKTNREKMMQIMFETFNTPAFYLQTEAVLSMYGSGRTTAVVVCSGDGVTHVVPIYDGFVLPHAVLRMGFAGRDLTGALTKDLSERGYPFFTSAEREVVKDIKEKLCYVAFDFDKELESAAISSSLEKEYELPDGQIITVGNERFSVPEFLFKPHMVGLDDPGVHEMVHNSVLRCDPDLKCDLYHNIILAGGNTMLRGLHDRMQKELNALTPSSIMAHVIAPLERKYTAWIGGSILASLTTFQNLWISKQEYNEYGAAFLHHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSD2</accession>
    <name>A0A8H5LSD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSD2"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5367718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="73" mass="8350" checksum="3DB3FEB6698AEE08" modified="2022-01-19" version="1">MGQTFNEIPQSLIPWIKEQHIFWIATAPLSESGHVNVSPKGIDGTFHVVDERTIWYEDLTGSGEWRRECFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSZ4</accession>
    <name>A0A8H5LSZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSZ4"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF132">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58252" checksum="72CAD3B666145698" modified="2022-01-19" version="1">MVASTWLRLIGSNDERSISLYISTHLYDQMVSSTQKHILFHSISLWGHHKPILPFAMQIIHSRPNIVISVLTCADVYAKAMVDIEKLPDDLKTDAKARFHVIDICGCPINALLPLLEFEPNLKAIYNGESIKCLSSGKTYQLPPITIAVLDPFAGYAVEAIREISENKTPYLFWVTVNAGSCFGFFRETPSGKLDLRTIRYGREQDIMPRLSEFVEPLPIMGNTFVDHARTYLASGRGMFILSSTPYDGEVIDATKEWFSSLGQVAYPVGPALLPDSPSALSVTSTRDNIKPVVKFLDRMQKEHGEKSVVYMSFGTFFWPQNPEKVWAVIKQLLASGTPLVWAHPSPLCVVPDDKLKMFQESDIAFEIKWAPQEEILSHPATGWFISHGGWNSIQEAMQYQVPQIFWPISADQPVNAATMTLVKKAGFELIEVRTGEYGTRKMYRFKDLDPKDLPTFTVDAVRREIRDLVVKLKGEEGLTVRKNFEKMSRGFMSVWNERGEARQSLDAFLEKFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTJ0</accession>
    <name>A0A8H5LTJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="169"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="625"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5369485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1282" mass="144371" checksum="84C71E96B162F0E9" modified="2022-01-19" version="1">MPHLTPSNASASASSTLSSATLVDSPSGAGNNVSFDDLEGKDLTEQLEILDKKLVQENRIKEGAENLLNMDELRQEVISELTTARSNIEAITSKKTDIESVLKAQQAQHKILKKKEESDERGEDFRTALRNAQSCISTLASLASAFISSDSSTSSPTSNEASDIDPQWIEVMTKLVYILQRNLRVRYQLKVQELVQSVIPALADKRSKQCRAVAYRVIRHALVDANSVKVMLEQQIDWYIVRSLHRDNKFAVEKEQVIKLIRAIIEVGVVFHDKGSKKVPLSEPIMRAFIAVAEQADDPFRLICIQTLAEIIVLDTELVARTGGIRALLHAIGEGPLEITPLLAFTFLHLVDSPRTRIYLNVGTDLEIALSAVTDAYGKSPEHVDRMKSCTKVIQLMLRTWSGLLYFCMDGMRAIRSLVDTLRIPSLETREIVLNMFFEVLSIQTPEWHQPYLAGRRLTTYQKSSSDTLKFEPEHFERKTTTVKLTDQYIGLMVLIFTNAGLLDALTSMLEESTAGNNMCRKATLLMGEILQLANRVLPLSVAAKIQAVPKLFSLASDYHDGEHRIVGTSALSSIDSFNRNRTRLEPGTAKNTTTSRIRANSVDDAIRRGQRQVEQVKIKIGMQMDDKTFQSSLIDTAVMTTKDHNKWNFDVLQELIEGPLLNPKRMEEAIKGARFMRRLMSFFHPFSSSRFSSMPRRVKHNHRWVRLGCSLLTTLMASTDGIRYLSSEDPFMSQLSKCFAQLFGLEQDPVFSRKHIAETLTHGYLEMLGTLSKHKEGIEILEKHNIFNAFYHLGDLKNRDDLIKGVIENLDYTIDGHPRIILAKALTSSHKDTQKFATGLLGELIRNSPVNSWTLRLLLTQLYDPAPEVRELAVHYVESVCESKEILELVVELRPTMSHLGDVGNSLLLKFMSTPTGFRYLFDTGYIDREMDIWFNERNLYYVVQVEVFLAQVFNSSSEDEDYHLGFEGTVPPHFYGEMAKTELGCVILQEKGHFAEFAQFIRQHAHESEDPELIMKLKSVLWAVGNVGATEGGLPFLEEEEIIPFVLEIANQSPIPSLRGTCFFVLGLISSTSQGAEILDDYHWEATLTPMGMPTGLCIPVDVDRFISLPPWEAVISEQTHTQIMPPTSEPEVEVINAIQNLANTVIANAASRSLAKMKSRPEYKSVFSSPTMFFRVLHIISTARYRLPVRRYIMELFNVDLDAQVIHTFAACAKTLQASPTWRPSPDLNRRFSMFGRTNPEGSDEDDGDDEDPPPLPNMTREQPPLNLRPVSRIVGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVC6</accession>
    <name>A0A8H5LVC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVC6"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="127" mass="13896" checksum="20071A38DC2C23EB" modified="2022-01-19" version="1">MAGLGVPVKLLHESLGHVITVELKTGQLYRGKLAEAEDNLNIALKDITVTGRDGRVSQLDQVYIRGSMVRFFIVPDMLQNAPMFKRVGPNAMRGRGIGTARGRATIMRANARRGRGVAPTTSRGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYN4</accession>
    <name>A0A8H5LYN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYN4"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15602" checksum="547B7BF4591C088C" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKVTGRKIDANALIDSGAEGIIINSRFAQENQLTLLPIKNPFPVRNVDGSKNTMGWVREYTIQNLRIYSQDNKAYHEEKAEFYVTDIGDHDIILGTDWLEEHNLEIDCESTHSPFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ27</accession>
    <name>A0A8H5LZ27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ27"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5375290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="386" mass="43009" checksum="6585FF7DC0068B4D" modified="2022-01-19" version="1">MTMHKDLFLLLREYGSLTSPKAITFPSHLPLAFITNFLIRSILSNPHFQRYPPATQFQQQWWKRIISLLEEQASKDQANEIDSRIFDYYVSLLPSSGPPPGSMQLEIRNQICGRGIPVVGELPSKSFITHFWKSATPGPDKSSVNGEGSEEINLHDYQVTTLQESRTLIESGTTGLRTWPASHVLAQYLIDHPEDLVENNRILELGCGIGFLGIIVATLQQLPSGDENESTSCVWLTDVNEEVLIQCRRNLQLACNLSSSHPRVHYHALDWSDALGSDTTALRTLLHDEINPSLILGADIVFDPSLVPLLVALLSLALGPTNLKRLALIALTVRNQETFDLFLSTAKEQGLHAEDVDVGNQHLFSVDAMPGSEPKDDVRILRFRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZP1</accession>
    <name>A0A8H5LZP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZP1"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="137"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="408" mass="44843" checksum="6045BA6169E1DC8D" modified="2022-01-19" version="1">MVQVWKMIFVCRDSALFSLLTTMQSATRAALLRRAIGVRSLATPSTPSTPKAAFTGTLNAGPSLDDFITGNAQDRVVLGNPRGPRLPSYLKTSIPSGKSFNKIKKDLRGLNLHTVCEEARCPNIGDCWGGKEGATEAEGRSAATATIMLMGDTCTRGCRFCSVKTSRTPPPLDPHEPENTAEAISRWGLGYIVLTTVDRDDLVDGGAHHFADTIRRIKQKAPHILVEALTGDFAGSLEHVSVVAKSGLDVYAHNVETVEELTPFVRDRRATFRQSLKVLQHAKREGVRVTKTSMMLGVGETEEQIMDALKELRKADVDVVTFGQYMRPTKRHMKVDRYVEPAEFDKWKQVAEDMGFLYVASGPLVRSSYKAGEYFIENVLRGKGTEKKAKVLLSENLGSSSPEAPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AUE9</accession>
    <name>A0A8H5AUE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000566">
        <property type="protein sequence ID" value="KAF5311255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AUE9"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5311255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61543" checksum="66743C2987D7F511" modified="2022-01-19" version="1">MTLRQSVTPSLRSSEDKPVYYARGLAVGKSLKCGHPPAQGDNIPVFLCPLHFRLEMYPTSSDNLSDAEKGNLSHVSSSDNLKKKDGSETATVTVQPVSALDTPPIGKEMAVPTLPKTPRKVPQRASRWIRFQLWFNTYRKFFTLVMTLNVIGLVLSAASVWTYPRHYTGAFVLGNLQAAILVRNELFGRLLYLIVNTLFAKWTPLALRLACTSILQHLGGIHSACAISGFMWLVFKIILIAVDMKNSHVAIFVMGVVTLAAITVSILSAFPWVRNTHHNVFEKHHRFIGWLGLIFTWVFVILGDSYDLDTHTFNADGDHIAKQQDFWFILGMSIFVIIPWLTVRRVKVEVEIPSPKAVILRFERGMQQGLLARISRSSAMEYHAFGIISEGIHSNKHYLICGVQGDFTKGLVENPPTHLWTRELKFAGVSNTSTLYKRGIRVCTGTGLGAALSTCLQSPDWYLIWIGSDQEKTFGPTIAGLIHDNLEGRVTLWDSKKRGGRPDTMQLIKDVYKSWNAEVVFITSNWSGNQEMMEGCKEAGIPAFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTF0</accession>
    <name>A0A8H5BTF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000372">
        <property type="protein sequence ID" value="KAF5328027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTF0"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5328027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1273" mass="139746" checksum="8893B8FFAE5B640F" modified="2022-01-19" version="1">MSESNIPLEDPMRIPATDTLADKALTQPTPNYHKNGAVEPEMAINMSLGSSNAETTEDSFVNHTPIDMDEWVELASLPLELFDEQVAQLHQRKVHKSNNSVMELLEHFKQSGDCAAIEDAVQLFGEAVDLTPDSHASKASWLNKLGNAFESRFQRLGELGDIENAIGFMQQAVDLIPDDHADKASWLSNLGNAFESRFQWLGELGDIEKATGFNQQAVDLTPDGHADKASWLNNLGTVFQTQFEHLGEVGDIEKAIGFNQQAVNLTPDGHASRPSRLNNLGTAFWSRFEHLGELGDMEKAIGFNQQAVDLTPDDHANKASLLLNLGNAFQSRFKCLGEQGDIEKAIGFNQQAVNLIPDGHADKASWLTNLGNAFQRRFECLGELGDIEKAIGFNQQAVDLTPDGHADKASWLNNLGAAFQTRFEHLGKLGDMEKAISFNQQAVKLTPDGHASRPSQLNNLGIAFQIQFDHLGGLGDMENAIGFMQQAVDLTPDGHANKASRLSNLGNAFQSRFQHLRELGDIENAIGFMCQAVDLTPDSHADKAFLLSNLGTAFQRRFEHLGELGDIKKAIGFKQQAVDLTPDGHASKASQLNNLGIAFQTQFEHLGELGDMEKAIGFNQQAVDLTPDGHAEKASWLNNLGTAFQTLFEHLGELGDIEKAIGFKQQAVDLTPDGHADKASWLSNLGNSLEHRFEHLGQLGDIMKASAVFQQATKNTSSPPSIRFKSACNWATLCLAHQGSSSALDAYKVVLEIIPQLVWLGQTVHQRYKELPKIGRTINAAVATAISVGNLTQAFEWLEEGRGIVWGQILQLQSPLDDLHDQYPLLAKDLERASRALQNAGTSTRSNIVDNPNTHAALTGGQEAQQHTRWAAEYEELLAKVRKLDGFDSFLKPKKLSALTPAAANGPIIIINVDQSRCDALVLSSSSDIIHVPLPNFSSEQAKEMYSAMNSSLQDSRVRVDCNDERYSQPHPVAVQHRNHLKLILARLWSTVVQRILSEIEDVLQYSAEGGLPHITWCATGALAFLPLHAAGIYCSQDASDNIKLSDFAVSSYTTTLSAMLSSGCNQPQKDWKEKPKILIISQPASLPWTEEEARIIQTYTSPEQSQHLTRDKAIVDTVKSEMSKYEIIHLACHGIQDPNPLDSAFVLYDGRLKLHDLMGLSLESAELAFLSACQTAAGDENLPEEAVHLAAGMLAVGYPSVIATMWSIRDKDAPIVADKFYESLLGRRDSEMATQNPRQSAAYALHAAVEHLRKEVGETAFVKWVPFIHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BTS6</accession>
    <name>A0A8H5BTS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_018196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000344">
        <property type="protein sequence ID" value="KAF5329220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BTS6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5329220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="389" mass="42100" checksum="07341F38D4293C4D" modified="2022-01-19" version="1">MVLPKIATAMSLPLNDGYSIPTISFGTGSKWKWHDVTTYVQLALESGFSHLDTAAFYETEPFVGCAIKESGLARKDLFLTTKCGLMIPLRKSLKNNLEKLGVEYVDLFLIHNHFFVPDIKEAWKEMEKLKEEGLTRSIGVSNYEVKHLKQTMRVAKVKPAVNQISLNPYNYAEMKPIIDYCQENGIVVEAYSSLAPITTYPGGPVDIPITAAGLRLGITPTQVIFLWVRAKGAVIVTTTSSKGRMKEYLAVNDLPPTSLTHEEIAAIDHAGANGPPPGPGPSSPSQPESTSSSSSFLTSSSFHLSPLSRILSSLSSWSSPSPPKDASLGVDLEKSPLPLPPSYPTTTQTPPPMRHPPTKITLVGVITILLLSITSILGIVLVLAGLFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVD5</accession>
    <name>A0A8H5BVD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000337">
        <property type="protein sequence ID" value="KAF5329934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVD5"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5329934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22904" checksum="ACD2B764BEB6ADDD" modified="2022-01-19" version="1">MSAITRNRQIPSITLKTELIGKVTGRKIDADALIDSGAEGIIINGQFAQKNQLTLLPIKNLFPVRNVDGSENTMGWVREYTIQNLRIYSRDGEAYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSRVDMTRCPETCITAKPPILHLKTKSLKPTVVDPRTHHKDYQGDVVEFPFDPSTKVRKKWQSLLKMTTGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZC9</accession>
    <name>A0A8H5BZC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000310">
        <property type="protein sequence ID" value="KAF5332357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZC9"/>
    <dbReference type="OrthoDB" id="94998at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5332357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="265" mass="28895" checksum="04F482773D06724B" modified="2022-01-19" version="1">MASLQLLDGAIVLSINGDNPFIAADATTKITGAWELVRIDRSPVTNIWEVGITFAQQSLPLNDSVTLKVQCVNKAKTDTNYVGNWLVQNSDDLQQHSLTRPQPSTAAIIDTDGPQELLNVMLDTLPLSNVAFPDRLTPPQNRPSFSSETAFSYSKMVSLGFCERTARLKDSARNGITRSNHWLHWIVLLGTKIRAGTLAQLVVESIIANNADPSVSSPFNPRHWTNDNNGHTFALDAFYDLTPTGVTNFSIVKAGSAIQITDFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C3A5</accession>
    <name>A0A8H5C3A5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000281">
        <property type="protein sequence ID" value="KAF5333886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C3A5"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5333886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="470" mass="53654" checksum="4F6A5C6F0709C6A3" modified="2022-01-19" version="1">MLWDKVDKKYSSPGPTSWFLDFKEFMSWMLDEKKDPANQIASLGAVLTRLKAYGFTVDDKFRALFLMDCISQSWGNYAQFTLATIEPKNLTMAHVEGLILVEYKQRTGQSSESSLLTGITGDKRKFDSAPNWNNQKAGSSKQKNQNKGKGKQPKPQEPSNNVTTGDANQGGDKKKKTRRSKKKGSKKGAANLANPEVEADSDSDDDAPLMVTAFMANPFINATLDPIEISDTDDLPETCEQPIYELLPYHNFLIVRSDCFIDKNNDSSLKERVKRNLAKQVRPQTILGYFILTHYERLMINELAQETVDFESFLRVEAHHQMTCKLAEIWDYTYNSDGTHTEPYLRAKEDLNGDEDMTNQWFDHEGTICPIQKQIEEEVEYFCCYIMNKALSDMRTHKWIPQQFKKHEPVPSKPPSLIERAYWPTPAQSVMRTNGVTINTQFHDTSLYPDFICTLPFNHTKASSSSSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C713</accession>
    <name>A0A8H5C713_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000235">
        <property type="protein sequence ID" value="KAF5335874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="678"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="721"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="885"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="928"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="971"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5335874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1321" mass="144932" checksum="5A8359DE2266E3A9" modified="2022-01-19" version="1">MLQKMVATKDDNNPSNNTGTLQADVGLFQQAHNFSIENSNIAVVGGNQYQYNNANHYYGLQHDIISKLNPAKKAFHDIGARGACIEGTRTEILEKIVKWAEDPSPDTPVGYWMCGMAGTGKSTIAKSVCLILEDKGLLAGAFFCSRQIQECKDYHNIIPTIAYQLAQHSRDSAPGIREALNMDPDIALKEPDNQIRKLLSDLCKNASSSYNPVMVIDALDECEDISNVLKPLISAIGNQKIQGLRFFLTSRPEQHIKDYFNVNNMQEEGQIFQHFYLHNVQRSTVTKDIVLFLQQGLTSMSISKDKMERLVESSGVLFIYAATIIKYITGGGKRSQARLANILDLKRTPDRIQTQVLDDLYGQILEEALSSSKLSPEEQEQSLKVIYTVITTAIPVSCQTISELLKLDLENIQAIITDLQSVLYINQSDQAIYTFHASFVDYMTSEARAKNHYCNPMSHHSLLAKHCLSLMQHQLNFNICNLPSSFLSDDNVPHLQSKIAQKFAGAFEYSCIFWAYHVTETEFDENIVEKMEAFFQLKIIFWIEAMNLLKKLPECTKILESISKLCQASKLTSHATKETIQEIKEMANVFGLSSVKKMTPHLYLSIMPFFPALSHRLVKVVKVASTVIPNHSIGHWRTPSGVLCMSVSPDGKKIVTGLKNNQCIMWNINNGEQIGKPFFGHQDWVRSVSFAPDGKRIVSGSDDSTIRIWDASTGELICKPLQGHEGWVYSVKISPDGTRIASGSKDKTIRIWNAFTGPAIGQPFQGHSGSVRSVAFSPDGTKIVSGSEDNTIKIWDATTGNKIGQFFDLDEWVTSVSFSPDGAKIASAAGGVIIWDAKIKSVLWQIKERCWQLAFSADETRIVSAFGQTMEIWDANTGTAVGQPYQGHEDDINSVVFSPDGSKIISGSDDQTVRIWDSHILPVVYEPGCGHQGGITCVAFSSDGARIVSSSYDKTIRIWDAYTGNAIGKPFLGHAHGVPSVAFSPDGARIASGSYDNTIRIWDTDTGSAIGEPLLGHADGVTSVAFSLDGARIASVSYDNTIRIWDAESGNAIGEPLLGHTDCIRSVVFSSNGTLIVSGSDDNTIRIWDSSTGNAIGQPLLGHKGRVHSVAFSSNGVRIVSGSGDGTIRIWDASTGNVIGQPLLGHTGGVHSVAFSLDGAKVVSGAEDKTIRIWDANTGYAIGQPLLGHIDWVRSVTFSPDGTRILSGSDDCTVRIWDATILTQAESSHWPLTNSASDKVIHPSHTDSSSSWYLDSGGWICFTGVKHRIIWIRPEHSSSLCTAQNPIIISQKGCIKLDLENCVYGENWTQCFNNTNDSGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8Q4</accession>
    <name>A0A8H5C8Q4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000222">
        <property type="protein sequence ID" value="KAF5336774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8Q4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="158" mass="16901" checksum="2C945931DD0B0790" modified="2022-01-19" version="1">MLCALVTKSAAVDQLNTTPSTYPPQTCAWTMLQDSSSPISWTSLFVAAHVSVLMQMTSAGDVSSLDTRTQVFPSILPVPRGLGRLGRLDCSAAGIALLCVCVRRDPRATYPISATPNQEIAGSTPAVVMVMVNYTMTRLIQEQKQILTQSGGIKVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9S9</accession>
    <name>A0A8H5C9S9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000207">
        <property type="protein sequence ID" value="KAF5337761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9S9"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="516" mass="55550" checksum="1F1E3D1125B4F8B4" modified="2022-01-19" version="1">MADATMSSVSPLSAEDTAAQAEAITVALKKQADWDEKNDKAIGSIKLRLSPAICQKTLGMTSAKEIWTTLKNTYGKPGVSAVYTDFKRATSITIPNDANPSAMIKLICMHFNRGQAHLVHGDMSPMMHTVTFVDTPTAVDSRTKRAINLACNIGVRPSGETVAALEDVVMSNPGPSSFTPLTPAPRPKRTLTEHIYWNNLQSSSDGWGCNDNWNDAFTRSVGTQTDSDADMGCVQEEDASWNEDTLVNTLELGSVFGSTTMESGLKVPQDTRTPVPLIDCLALDPAAKIMECGIHLGERFQNPEDPLHIYGEGATPFQAVVNTCASTGTLSLVQRLAAVHSEMQSGSLPAHPSGMTTQSLPSSRVASPTPGMTSMGWEWLTPHLENEDGRYDELLDWQRDATVGLGGMEMEEELPSRVLTPSSMPELQSMSPSLSSTSDLEYMSTLQSLSRMSHSTDPREATLSASIAAVGAWSDGIPSQRPSTPTMVIGSAANNYGWSLDSEVSGMDNGYLRSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAM5</accession>
    <name>A0A8H5CAM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAM5"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5338225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29989" checksum="747573C62F1E4BE3" modified="2022-01-19" version="1">MSGSVDIPGSPHSVHSSLSGLSGLSGSPPTLDPGTLSILDQFLSDKAEEETLFNTLSQQATALDVAGLALEEDKDEKPMISVDQYRKAFGEDWQLSQFWYSTSFATRLAKAMYSICEPSTTVAFLCCPTAFVAFQHEYPQKNTYLLEFDQRFSVLAPKLFIPYDLDEPDDFPNTLREKVDLAVVDPPFLNEITNQKLSQTLRQILHPTRGKLLVITSTSVEPVLFKVYSDAPLGPLRKTALNVEHGQLANDFASWGSWEGAEKFGAEVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAQ5</accession>
    <name>A0A8H5CAQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAQ5"/>
    <dbReference type="OrthoDB" id="2866758at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034127866" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="152" mass="15763" checksum="312D417D03169EAD" modified="2022-01-19" version="1">MLFSSAFVFASLLGTSFAAPLLRLPKRKLADLSTGGVPGSAFLADDAFFAQNECNIQVNPGDLVFLISRAFLKNSAPGSSAADNGLCGRSDATIFVLDGNEDPITENTSALAPVGICEECAEGDVVVNLATFNELGGDPTTGVINNVFPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAZ9</accession>
    <name>A0A8H5CAZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_012221</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000196">
        <property type="protein sequence ID" value="KAF5338419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAZ9"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5338419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="87" mass="10158" checksum="245150ECFE8136CA" modified="2022-01-19" version="1">MSGRQSRVMVQPINVIFKNLQQRTKVVIWLYDNIEMRIEGRIIGFDEFMNVVIDEAAEVFVKEAKPRRELGRILLKGDNITLIQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBY6</accession>
    <name>A0A8H5CBY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBY6"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034537173" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5337943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="401" mass="42963" checksum="084F48373D9D36E3" modified="2022-01-19" version="1">MVNRLALTLALFTSQLLCLVKGYDLVRDYSGITFFDEWDFYGSWDNLTGGDVNWLSESDAFSQGLAYVNSANNAILKVDNTHNVDYLQKRNSVRITTKDSYAVGSLWIIDLRHIPFGCSVWPAFWTKGPVWPENGEIDIIEAINLMPNNQMALHTTSGCMHTTPPNQMGQTLEPDCSHPAGCTVGELQPNSFGPGFAEMGGGVWATQFDVQGIFIWFWSRLDVPPSILSSTPTSAIDVSDFGPPSASYLATSCNITQFFTPQNLILDITLCGIWAGLPETWLPSCGGQGPTNICYTDDVIGPGSNYNDAFFEISYVRAYTTGGVVPTPTAAATPIAAVNPDHLFTTVVTAKPSPDGILRPSPLFFPGNGATGLRGGGFSSVAVGIGAVLVGLHVGIGMVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCZ3</accession>
    <name>A0A8H5CCZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000198">
        <property type="protein sequence ID" value="KAF5338242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCZ3"/>
    <dbReference type="OrthoDB" id="2890875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49740" checksum="A26A7BC30BA74DF0" modified="2022-01-19" version="1">MIFTLVAPLEIEDAENNTNPFNPLLPSVSLASVCRGWHDVAYDSPQLWSVFDINFSSLSPGAIHVIDSCLTRSKNSPLSVHLHGELSVNRVIWQDVLTSLIRQSSRWKYFFFEVERSMSTSIKEYSASRNVLQKLMAGIEDLPALDSLRFESTFIDGISPLLARMSCRSPHLRSLTLHGELLPLDDELLEQSAGLSSLESLSVSGIPLHTFVDFLRGDAFRDLKSLVLQGLEIYEEDSDIIPDRQSLVTFQHLSSLSIYQTDGADMGVTLEFLAQMLQAPSLQTLDIKTGLIFGPVIIEPLHTFLTSTKCTTSLTTLHLEGVRDVALLLPLFPNLRTLSVSETHYSGRTLGDIIGALRLGGGRDGGHDLVPKLQHLELKAMRPDLSLFSSLAEMAKSRWNSGSTVDGAACLSKLSLEVSEGLIDRDTEGYRALEELKAAGLDVEYNLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDE6</accession>
    <name>A0A8H5CDE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDE6"/>
    <dbReference type="OrthoDB" id="3068307at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034039084" description="Transmembrane protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5339709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43460" checksum="022261C0D64F0B09" modified="2022-01-19" version="1">MPLCLLVLLLTFVPLFGSCLTDLHNVTIDDASNATGIASLSFTPVDAWSAETNNFNGNEKNVTWHESHYDPESSPLVPTVTLFFNGTTAVYVYCIIVPGCVSRALCMQDWTGVETVITSVSSSMSFHLDGAFVGQESPIASDSSEKLIVFANTNLSMGPHSLIIQNGDPSGLASSLFLDSVIVTIPSETSENLGSDFFANKGAVIGIFTTVTIVFVVATVFILWFVQRRKAQRRHSQNRQTQSPSQMEATADSGVTGTLRPFDLKYDRRVFLGPEEIRPYDLKYEEPELPATNLVAPLAHDSGLLNAPGSPSLTRENSTHSTPTIRQVRLQQEANDLRQRVRGLQQAVNISIVEMQGMQDTVMRILGRVQELEDQMNSDWARGLTDELPPVYATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGX2</accession>
    <name>A0A8H5CGX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGX2"/>
    <dbReference type="OrthoDB" id="3018813at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="567" mass="63522" checksum="80643EF0AE4D376C" modified="2022-01-19" version="1">MDQNKVAFDRERMVRNQKTASMVAFVSFDRGRNTAPVNSRLQPVRPPSPPEIPPPMSRISKPFRIKPREQSSTTHLAPTQHIYQRNHAFNPTMQLINVHSSPSTSSPTASLRYSSYMGLQPHRMILTPLTDRQLDVQSLIHQLQARMIRLEANANDPNDDKNTVEEIEEEVTITRLKADVEKLRNVRESEWARGVSDEVPKEWEELRNSSTAAVRIQSYNNTFSWIRDSNDPADFFLQKIKIDGDDGPTTPSPPVAVPNIAAAGGQGLMHFNRAGNPKKAFFNMLVTVQDPNSVSGVPQGNNSSDSDDDGQNGSNRHNGNGNHNHGGDNDDNNQMMTPGNGKPSSTQQDIPKIVGIVLGVVAFMFLIAALLIYRRYRRRRQTNNFQRNMMFRSPGSVKPFLISQPMDPEKQNDFSSPSSFSQPGTYAAGLAYQRAPSTISDSIGTSVSQRRPNEVKGPRNRDSGTTATSSNQSDDTGDNEGSLVQFPVPSFPARIRTSRQIMVEEDIQTLQRKMLELQARRDLTGVDAIDREEQMKEVKERVERLKKVHEGPWALRQTEAIPAELFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CK10</accession>
    <name>A0A8H5CK10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000148">
        <property type="protein sequence ID" value="KAF5343140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CK10"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="110" mass="12400" checksum="4D98368842F708B3" modified="2022-01-19" version="1">MPVVTASSQVSYIGTGDIILGALFFLVFVLVNLLFMYLEEPVVASHYEEGKPDQNLNPSVAFDLNTGEKRSKRCYPTILDESRSSWSDYPGFEQIHPGYLFSDGKEHQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKX2</accession>
    <name>A0A8H5CKX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional coregulator SSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_014177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000142">
        <property type="protein sequence ID" value="KAF5343353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKX2"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034023344" description="Transcriptional coregulator SSA1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="802"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5343353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="843" mass="90570" checksum="6FA499B7476FFF5D" modified="2022-01-19" version="1">MQLTGLITIAAAFTSVLIAPVSAVPAAQSTNAGLSLTLGSTLTAGNHYGAPTPPWKKGASPGWYYGDHPEHLDIFKFFVPHLKDSLICKLLDLLPFCLHCPKPYHAPPPPPPPPPPPPQYPPHSSPPPPPPSPPSDGWKQTFSGLNAATEAYGYLTYGLVDTVDDCKAMCLGVQGCVFINTYHDVNGKTTMSSSKAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVSFSDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFDDAEVQADIKHFPFKVTNKAGKPYIEVQYRGETKEFSPEEISSMVLLKMKETAESYLGTTVTNAVVTVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVQGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKNKKDLSPMPVPFVVSAPLASVPSGTLSSAAQTSIEIDSLFEGIDFYTSLTRARFEELCQDLFRSTLEPVEKVLRDSKIDKANVHDIVLVGGSTRIPRIVKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILSGDTSEKTQDLLLLDVAPLSLGIETAGGVMTALIKRNTTVPTKKSEIFSTYADNQPAVTIQVYEGERARTKDNNLLGKFDLQGIPPAPRGVPQIEVTFDMDANGILNVSASDKTTGKSSRITITNDKGRLSKEEIERMVSEAEKYKAEDEAAASRITAKNSLESYAYNLRNSLTSPELSDKFDPSDKSKLESAVNEAISWLDNSQEASKEEYEERQKELEGVANPIMQKLYGGAGGVPGGAGGVPGGAPGGFPGAGAGTGAPSEDGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM59</accession>
    <name>A0A8H5CM59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_016928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000146">
        <property type="protein sequence ID" value="KAF5343192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM59"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5343192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="636" mass="71975" checksum="434EF5A41D0A1489" modified="2022-01-19" version="1">MADTEMVPTFAEDEKIDIADEKEETEKIEIGRDLLDVTDVGEVFAEGPRLIDLEENDKERPIKTDTDYSMRLISLEDDPSLRINLQDVYFRPQTIAVSSLFLQIISFIFGKVLEEIVPGPSETACIKTRNNRFWRFMNHGPFNLKEHVSITIMASTASTSALAISIFASQDLYYHIRPNAGVGIFTYVRPTLVQHICPIGQSQADKPIFRPIIRLIASQLIGYGMAVYSQLMPTVQLFDDLHRGQDAIMQKKRLRFFWILFIGIFVWEWFPEYIAPIFGGTSNNEGLGMFSICFDWAYVGSGGGTIGTLFTPLSTMLSLYGVCAVCMYVFSGTEYDQLAILNDDFTLNFEKLEEQGLPWYAGAQLLYLLHRTIYIGAAITHFFIWHWGTIYKILKNYWTEECQDPHYRKMKVCKEITNWAYFGIFVVCLALAIGLAYAAKSGLPAWALIIAMLGGALVPGKPVANMYFTLCGENPILQALALLGDLKMGQYTKIPPRVTFMLQMAGTIVGGILNFIIVTTVMNPQHPVLLDLQGTNGALGKPLYATGTRYGFVPYMLLVGLGVPIPFWLAHKRWPKVGFNYVFTQILVAELGFLSVGINSSVFTTFVISVFSQYYLRKYRATWFRKYKYVHYLINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMN1</accession>
    <name>A0A8H5CMN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMN1"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="196" mass="22341" checksum="5686021EFE7D0D78" modified="2022-01-19" version="1">MSRMDKDSVTKFPPSSSFPELPPELWILIFSFATRLPRYPMLFRREDATKSQSKRYQASSVTKRHLIVSKTRISLLAAPFLYEHLMLINFQTLPIPNMKAIMDCVPAASIIAFDAGDMYSSDYVTMPPALHKVAPPVHVLNWHLSFASIFLAKFKLPFPNIVNLTSLQLCWLWSDISNPALASSPNPQFQKVRLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNZ0</accession>
    <name>A0A8H5CNZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNZ0"/>
    <dbReference type="OrthoDB" id="3265672at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5344348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="621" mass="70273" checksum="277D20688C214874" modified="2022-01-19" version="1">MRGVCCKLRADLYPLYSHSFPMPPKPPLNLDILDDPDASQEERLQYAVDAMLQDPRRSQRAVAKFYKVPRATLGTRLKGVPTHREAHEHQQNLSNAQEKVVEEWASVRARRGVPLTLSLLGTYAAYICGRELRTTWPRRFVDRCPNLKLKLTTSLEACRAKALNAKLVNEYFDLLESVIVEYHIEPQDIWNMDEKGIQLGVGARIKALVDRDQKSVYSVHSGNRDLITIIEAVNASGKCLYPSFIFEAVKRDLGWGENNPDGASISTSPNGWTDQQLGAMWLEKDFEPNTRPDPSLEDQIKWRLLILDGHNSHCTFRFCNFAEEHRILVICLPPHTTHALQPCNVGVFGPVAKKWKSLVTKLAHRAVDIDKYNVLFYYAAARGSSITPPNVISAFAACGIHPLNRNVITPDMMEPSKNTTTKAALPIPPRFPSFLTPVIDSSQTPSSDDHPVEPSVTGLSVELPKKRRKNATRANVILENEELRVLVEKCVEGMSEMYVHMKLMEVENADLRKRAFDRTTKKKTVYFEGAQLMTSIEMLDALARSTWGAKMKDVFKELQPKFKKIKAAIKAHEKGLDKAAKDAEKKAAQEQKACERAEKQRQVAEEKERKRVEKEKIKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQV9</accession>
    <name>A0A8H5CQV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000103">
        <property type="protein sequence ID" value="KAF5346322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQV9"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28864" checksum="35E20BFAFC5F44D5" modified="2022-01-19" version="1">MGCHGLPIPGKSGKYILLIPFAADTYDTEARSYALNYKRIPYKVVWVEYPDIEGEMKKLGIQPTDTYPDGSPGPCYTLPAVYDPTTKRGISDSVLVARYLDDTYPDRPMLFPPGTRTLQAPWSDVLTWPFVAPMLQFMMPATTWFVNPPSEKFLRARNPIPMEEVYPSGEKKVVEWQKVEKGFAKMEKWFEKEDTFICGKTVTFADFALGAYLMWTKCVLGPDSEEWKDITSWNNGRWGKFLQSLEKYEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYM7</accession>
    <name>A0A8H5CYM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYM7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="124" mass="13329" checksum="ADBD9976C7AF5541" modified="2022-01-19" version="1">MEKHRNCKAGNPIIVTLCAVSSTTPVENDAARSYLTSISVFEGEVKGRVRARLVQGRHVRSIMSIASKPSQTSTSNSTSNANSTDNENTRWVVEIRPGMSSAGVRDVPDEDENVRGGKESASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZS5</accession>
    <name>A0A8H5CZS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000072">
        <property type="protein sequence ID" value="KAF5350880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZS5"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5350880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="310" mass="35067" checksum="8AF5A8134AAE4F15" modified="2022-01-19" version="1">MADSSDQPTYNLNERCLCYHGPLIYEAKILKIQDFPEPVATTGVAGTHFFVHYKGWKQTWDEWVPPTRLLKLDETNIAKQKSLNEQAKAANAASSNKAHGKSSATSARDRESISAVGTRAGARKDGARGVKRAREDDDNIRRNEMKIVVPEVLKVILVDDWEAVTKNNQTVALPRSPTVEQLLKQFEEHIKTVKPPNLREPEILSRTIITGLQVYFDRSLGMNFALPPRTASVKIEENVEMSSIYGAEHLLRMLVAMPQMVANSQMDPESVGLVRDYVNELLKYMEAEKDRIFLREYETTSQSYQNTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2H4</accession>
    <name>A0A8H5D2H4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2H4"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5351526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="424" mass="46441" checksum="13E4384C6B133A5F" modified="2022-01-19" version="1">MASGNVSALLKPVQIGPYTARNRIFMSAMGRNRSVPTSVPNELNVEYYRQRARSAGLIVTEALLISRQGIEWPYSPGIWSSEQIEGWRKVVEAVHAEGGLIYAQVFHAGRVCHPEAPEQIAAGVPVYGPSAIAARGGKFRHIPGKPNAPYVVPAPIDDPEKFVALFKQAAVNVKEAGFDGIEVHASNGYLVNQFLESHSNQRTDEYGGSKENRARFVLETLQELIDIWGPERVGIRLSPGGGYNDMGMPLDETIDTYSYVTSEIDKLGIGYITFLRYSEATDPVFDGKNRGTPHDVVGTYSPLVKNPKTAVLVNTGFTVEEGAEVVDKGIAAAVLYGMNWIVHPDFAKRVQDGKPLDGIQRLDMMGLYGHYPPYPHSEDQLKGEKLAQLKEDLKRGYTDYPDADVALPGAQDVPVANKMVSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D585</accession>
    <name>A0A8H5D585_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D585"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="45492" checksum="8B4AFC8E97C90E17" modified="2022-01-19" version="1">MYALVSHGRSGDGVNKKNFKLKTVCSNPPFPPRTAWLHYFCSLFYTMSSSIVQGAYYINDQRLANYFHLVGFVFLVWDHVLTFPLEVKYIWRRSFNTTTWAILFNRYFPVIGTVIMTINAFDGSLPHSMYKLLIARFSCEPLHIFHEAYLFVTEVNVCLLLTLRIYAIYDRNKRVLGFMAFVGLILGGLALFASFYTFVPSTDPPVSLTSMGCHTDLDVIPHGAQEAAAWEALFVYDCLLFTMIILKGRKTRRSVGRVPLLDIIIQDGASYFGVMAVANLANILTFYFAGPSTRGGLSTFSNAVSVTMMSRLTFHLHENAKIDSFQPGSTAQSSTVLTSAPDAYQDTCQFTSYGYDRSEQHPPYVDRGNAHEAADDEERQVGGLGIPMRTISRENVVYGESSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6C4</accession>
    <name>A0A8H5D6C4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6C4"/>
    <dbReference type="OrthoDB" id="2884912at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034526104" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="154" mass="16432" checksum="7CE292575C203C86" modified="2022-01-19" version="1">MMLSTRLIIPLSFVSLITPGLASLVQRKELSSFSEKDSIPFAVLTVCTAIDFDGNCADIPAEDDLIDCLDLVGGFTGLNKEISSAVVPEGFDCNFFSNFACTLSQTSPLHSKLSLSSGSFSDFLNISDTIAGGVRGTRDFNDRTSSIKCIKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6D1</accession>
    <name>A0A8H5D6D1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_008816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6D1"/>
    <dbReference type="OrthoDB" id="3247165at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="340"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5353062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="897" mass="102283" checksum="6512FD837021E6E2" modified="2022-01-19" version="1">MCLYDWIQLCERVKAPKKSQTKLTTEPVAEQYDANKLFEAETTLSDSDLDDIESDTEAELQENEYSQCPKPLERADLPKNMFPFLAGHPLADSHVLKVASERQRLVPNFIGGVLPRADCGSREYYCCVMLTFFKPWRSGESLKDMDQSWDSTFENFEFSPRQKEVLKNFQVRYECLDARDDYNAQRKTMSGDTDNIHIPEYDDGLDCDILDVSADPLINGESGPLEKRRQEHMNEMKDMLTGMGWNETLHDCRLHIPAEFNPETDRSAHSWRLQINKMRQAILDERHKPKNSSNNNSKFPNKFPNQVEILDKTAFEQNTRKGQTQDLIDQIAREFQFENNIEQDRAFRIIANHAVSPCPQQLKMYIGGMGGTGKSTVLRALRKFFAERNESYRMLVVAPTGNAAALLAGSTYHYMFGINSKSEGEFHSTSMSQICSRLEGVNYIFLDEVSMLSCKDMYKISAKLATALNLAHLPFGGMNMIFAGDFSQLPPAIGGEGVALYSHSIGSSPKSKSDQESSIGQHLWHQITTVVMLRKNMRQTQTSDRDTMYRTALENMRYRSCTPQDTTFLRSLIASPHNSMKSLREENFRNTPIILTYNKHKDVVNRLGTERFAAETGQKLTSFYSEDEHIVLDDIPEHEKQSRKRRKSRKFKVNNSIQNQLWNQPHSYSDKQTPGRLDLCLGMPMVIRFNSATELCITKGQEGHVHGWKSKKGKHGKPVLDVLFIKLHNPPKPPSPIQFDGLPENVVPITRNTVRIECKLADDSEITISRQQVEVLPNFAMTDFASQGKTRDWNVVDINNSKDFRAIYTALSRSACANQTLILQGFNTSLLTGGLRNKGGYRQELRELEILDEITRLKYSSQLPVSVVGDRRSSLIKSFRNWKGPNFVPSNVHESIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6J9</accession>
    <name>A0A8H5D6J9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_008739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6J9"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058504">
        <property type="entry name" value="DUF8191"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26609">
        <property type="entry name" value="DUF8191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5353152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="577" mass="65601" checksum="FE6D86A836B84623" modified="2022-01-19" version="1">MSVIMSRASTSTNNLIPFKRLRSSRRDHHSSHQNEEVVVAASSSSKSRSTRPDPFATSSIASRKHDPSIEDLSDSGQRIMITRASHSTANNANSSSVELHHRPVVQLSRYPSSGDLMRKDKGKDRERVDRIENTSKSHHREATHSKKHAHDESDSFTGSLAAAEFERLKKENESLKKSVKKQTKKIEEMKAQIQAGKTVKREHEDQVRTLKSKVQNNEEFIASMESALQCQICMDTYYKPFALAPCGHVYCLSCLQDWFKKAPASGDDMDIDPEQLDDPDYILSRQKTCPSCRGVITRRPAPLFMVNNIVSAFRKAKGLPTSLPLPSSNAVGAGALASVLSRRSTSPLVGDEDPWDGIFYEDVDSEEDDMEDEMESEYMYGYMFGDDDEFYSGEESYDGDAGFYGHSDEEIEEDEESSSGDDEDHDDSYVYPRWEPPSFVRGRNRAPNDSAHLALVRRGCTEWMINRFHLEYIHGNGLIAYLHSFSVNELDDPVPDDISPDSMNRLFLGWNVQRYDHTLGRRMTGKEYMRHILQLLHDCPERFVEEPGRVPGTEDVHMLMRSDETMEYDTTDSEYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D809</accession>
    <name>A0A8H5D809_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_006049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D809"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829:SF1">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="465"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="567"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5355266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="679" mass="74115" checksum="21F8436B6083906F" modified="2022-01-19" version="1">MDYSSDRSVIEWDENDVQQWLTSLGLSQYEEKFKEHRISGDILCMLDTDALKGVGVTSIGQRLSILKSVYLLKIQHNIPLEVDDYVPPSQERSENLSLDKIHALVKEQDQRLRVLEEENRNLNTILQSFFDDYNNVRASLSRTDENTIPSIRRQPSFKWAQFKPNKSPTKADMGVESPHPSPHQLEHDIAPYTRGHPQSQISSSNLAPEKSRLQTGPSDTPSTSQPSAPKPVRQESSDNLKSFKVSLEDPTWKVLPAALKKYRINNDNWENYAMFICYGSPGNRIERCLSYDEKPLLLFQKLKDAKKNPVFMLKHIKDIRSPIVVAQQKHAARKASSIMSANGDANAAQSKGTPSRSTTRPPRLEVNDLSTSTPLMSGISPQPNWPEPGVSSPSAEQQKAPDDGSTAPGSAGTGGSVSTAATGSTLVASSTANGQDLSKSRGGSGSSESVEQPSSSSREMPVASAGVSYAVAIYPYMAEQEDEFDVVVGDTFVILSRARGWWVVQRDPTGSGVVDTDIVKQGWVPAGCLLETNVPVASAIAEAKSSASTNGESSPSRTPILPLSIISTSFPGIALMDYKKKGDEELDLVKDDALRVFKRYNHWSYAVKEEGGDRGWVPSWFIGKVAPAGNVPPTPSTSVPPNMSMNNSSINLDDSSTQPQVSPMSSAFPTHQSRTPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D856</accession>
    <name>A0A8H5D856_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_006061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D856"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5355275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="426" mass="48731" checksum="E84F27F2762FE4DF" modified="2022-01-19" version="1">MSPAQYRQYPSFSSNPSSSTCHDSYPCRRIDLADLDFLKLISGGGSGKVFLVRDRVQMQYLALKVMPKRRELNTVSNVLNERKTHSALSLEDNRYFLPLVASWHDEVNYYIATEYLPGGDLALHLAKHRIFSEQRAKFYVCEIILALEELHAHKIIHRDLKPSNIMLKADGHIVLGDFGISRHFESRDPSAAFERDSMDSAICLPHKRFDAASYLTSDDCGTTYYMAPEQHLCMKYSFEVDYWALGVILYRMLTGLMPFGQTSSSKHEIACSVIHDELRFPNTVFISPEAQDFIRGLLVKDPGERIHFSEIKNDPFFDGVNWAAVSRCQLPSSWRPYIPPNPRHPHTVLPFEYGTPFDYHSDPLPSFTWYRPSDLRKRRDMASLPSEYTPHPCKDITSIGKLMRPLKQGLGTLFGTGKGQTRQKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FB01</accession>
    <name>A0A8H5FB01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000331">
        <property type="protein sequence ID" value="KAF5330251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FB01"/>
    <dbReference type="OrthoDB" id="621413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5330251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22851" checksum="F757935873C25BEA" modified="2022-01-19" version="1">MSSYSSNLSGVSERSDSGNGEDVSAIRRSAESLETLGYHYHMQNQFEDSRNMYQQAKEQFKKIGDRQGAGNCLERLGNYYNMADQYEDAKDMYQQAKEQFEEIGDRQGAGRQGVVECLQTLARMCNWGSQYSEAKDLYQQAREQFEKIGDRREAAECLRIRGLLCQSGKEYGDARDMLQQAKSYFEEVGDGERPAECLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FDW8</accession>
    <name>A0A8H5FDW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000296">
        <property type="protein sequence ID" value="KAF5332967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FDW8"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5332967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="853" mass="95567" checksum="461EA896BCF97B72" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGENTRTDVRDTVPTPPSSPPSTSTSSVALSVPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVIRHQHFKSSRLHPGNTVKLACFNAITGKIDDKIMIHYIEESDAIELINKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYKATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPLKKSDKKSGSTSQGGAQRSDKSKGERTNAVAPFQKPSDVKKDWKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPAPSSSQIATMSTSQSDWVQSISSGDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLFFNVHTTPAITLTVANSEHLDLRLAGDMRVEVRKDNTRTSKLTPKGNRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTNETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLYNEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQPRYPNDPGEEHYAAAKQCYLYLKGTCDYWLNLGSPTITSTYGFADSDGMSTYGNKPIMGYTFKFAESLISWSSKRGTLVTLSVTEAELCALAHASQEAIYLKDFIEEILNAEQEPVLINSDSASTLAIIRAPEEQHTQRTKHFNIHKNFLTDRIHQRYIRVKHVSTNDQLADILTKALSTDKIKCFSRLLGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEX0</accession>
    <name>A0A8H5FEX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000264">
        <property type="protein sequence ID" value="KAF5334244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEX0"/>
    <dbReference type="OrthoDB" id="3003917at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5334244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="519" mass="57843" checksum="2D66C90E9BAA7C93" modified="2022-01-19" version="1">MVFLVFHDWVVRPVSARVKRDAWVYVLSFRNSKACKIGCTRRTPRRRLQEWRCKDKSKGFKLVYSVQVSEERMFGIEHEAHQQVLKYTHKSNGACPNCSSKHREEFVFKAAFGLRDACDAVDMAKELSVTNQFTTVMAVVSNYSLALDIKPKIAWTENQEKPSATLLDPLVLTTRSITDKYRGLPILLDKICNEEEAEELGIEESIYFTGTLFTSPVENEEKEAAKDDASVDIDTRHHKQARTSVSIAKISIKRDSSKLSKHLSVSSSSSSTRHPSPALSATSSTSHTRERHPSRPLERSRSRSLSVTLAEEEHQKAVEAKERQHQRADSVGIGGVKKRVLSREVSMTRVFKPKARSQTTMVTVEKTVKPVVKTEPKDLVVTLVEATLEKPRIVPGRTLNLSQSQLQQAVPPLPLLILLPHSSSSLQPGSQQTGQSCTRSKNPGPGGLNLSELSEPEGDVDEVGNSDAEVEAEEVWYPPASSSPDVLLLSDKLKVLTSKIFHRLDLILVMKAMTMTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEZ1</accession>
    <name>A0A8H5FEZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000273">
        <property type="protein sequence ID" value="KAF5334033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FEZ1"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Berberine/berberine-like" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5334033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="295" mass="32341" checksum="F4728B6103967850" modified="2022-01-19" version="1">MVERGITLGMGFRAKDMGGHILLVTVVLANGAIAEISEVSGIHSSSPSLALTTSLRFHTHPIPPSGRMFAQFVRDVPTSIATQTMEAYKQFALSPNLANGVLKRASQRGRVRLLLSTTYFAMTPGLSEEEVEARFHETLKGFLDVTVLPEPGTGTTLVTGSYINMLGAEVPLTDEAMGAMMEYLGTVGRDGELLYPVEVELYSAVNSAINAPPLDDTAFAHRNTLWTFQLYVSSPNSLLPYPEEGFVFMDGIVRSIVDNMPPGWGYGAYPNYIDDCLGDWQHRYYGPHYPRLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHK2</accession>
    <name>A0A8H5FHK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000225">
        <property type="protein sequence ID" value="KAF5336688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHK2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="791"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5336688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122053" checksum="4591A573B2D55BB2" modified="2022-01-19" version="1">MNYHHIPPHPQFLPQPPYPQHPIQFYPQFPPGLPHPQAIPPPPNPYAIHNYRPPPGLPPPAPHPHPLSHPPPPPPPPPAPLKPTENGWYIPPNAPPANETVVYETSRNGSPNHPSNEGDGSIHPYWHGRLAPLPGSCSPEDTFAPRKETQTLPHAIEIKTASNNDISLNTRHLLPPPSSGSSLVSPLSMSSSPSTDITSKIAEHGQLDKYADVFIPQYLKDIQTQSQKFTPLKAISLFPPPSYLSTFLPSSIIDRVQSLYPSTVLSGPPHPSRSHSFSSPNSSFFDEVNFPPLTPSASNHWRALLSWELDQQTREKEKIVLYQMNVSVQDWDQAEFAVCVVGIRENHPRLDIGDIIHLREVLVDWKCGSGVAFEGRITTLRKREGFIHFYCPALKQHIQTYIPVTLNQQIRDGLPVFTSQDKIPPVFNISFLTNARPSLLMERAAATLGAALSSGNETGKRGLAHRWLFPTNPTSKTPTRDLYPPLHPCYHPYPTPTVTVGSTEGSTPNNEPLLPQSHYINLPFRILLVDLQPEACILLCAPSNPATDTLALRLGKDLGPHEMLRLNDENRTFAEVPDGIRQFCYVDNDKFALPPFKQLMRYRVVITSCLDANILVAAECTNTTLALLEEHVMGSIHPHHMMKHQLVPHWTHLLIDEAAQGSEPELLIPISVVLTRPELLMEHESERVMKQHQHARKASIVSYNYHPLALTPQLVLCGDPNQLGPIITSDEARAHELDISLLERLFESPLYAEHSEARSRLHLELEDGYPHSPTRNHNHVQNHRNVKPFKPFANLVKNYRSHPAILMPPSAMFYNDSLEPYATNGFISWNKLPNNKFPLMFVGCDSKEEDVSESFIVLTWFFVFVSVSRLRFTITVTNLDVVLSLMSRATWFNPGEIASVVDIILSMMKNADKCSPVLTPAQIGVMAPWREQVWKMREALRKVGLGAVDVGSVEDFQGREKRIVIISCVRSSARFLKEDEVKGIGLVFEKKRMNVAITRAKELLVVVGNGELLKRDPYWKGFLQFALRNKLYVGPDLGLELDGAWISRLESQILQAQEETGLLDADDSEDRNTMMLAGDVAREVLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJ01</accession>
    <name>A0A8H5FJ01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000195">
        <property type="protein sequence ID" value="KAF5338549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJ01"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="240"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="79778" checksum="74E32BAB102C2FA5" modified="2022-01-19" version="1">MNNCPEPSLQSALDPSSVMRLLHTKDFTVKQFFDDIPRYVILSHTWEQDEVTFQDIQNLDIARSKTGWRKVENACARARRYCFDWIWIDSCCINKESSAELSEALNSMYQYYEDAAMCYVYLSDVSGEYHPGSEKSNFRDSRWFKRGWTLQELLAPEYVVFLDEGWERIGTRWGLRGVVSAVTGIPVDVFEGRIVDEYSVAQRMSWAAFRETTRPEDQAYCLLGVFGVSMSPIYGEGGVKAFMRLQQEIIRISDDRSIFAWVAVPPTKELKPWEFDRPARNTETRGLLARSPYEFRMSGDVQASNVELIGNQSSYSFNNNGLHIHLPFNPIPSSSEHFGEPIFLAHLLCQSTRGGSHLTVYLRKTSGHQYVRCHPDEIFLTSSPPPMDDVRELTVTERLVTGRRVRASNTSGSISQYEIELLRSAWDFHQEKAIGSYVNSRIDEHTVSLFVDEYPHDAVGYKSRQTGDSFRIVRINGRPSLSIGDSWIEGSIPGDTLLGQLDSGNYLMITSERRGDFSEKIDVGYLAKDDPEIRLWTGPLRLPDLGVIVHSMLSSEGYDLHLEFQGIFPPDPFGRITQDMAYATVFRPHPDDPKECSHPTFRLLTYRQWDISFFGSCIVHVAFGLQGSSVWTDIVVQYSYSNDTSEYVWKSYLDSGPRAGKRLKGEGFAEARSVTAEIKRTKNLQLGDYSLRMYWKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNG5</accession>
    <name>A0A8H5FNG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-hemolytic phospholipase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000144">
        <property type="protein sequence ID" value="KAF5343271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNG5"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="70689" checksum="8ADB840F50A0B25E" modified="2022-01-19" version="1">MPLSMKQVALGFLASSLTYSTVSKADSLADVDHVVLFMQENRAFDHYFGTMAGVRGFKDPNVQINPNNRSVFFQQVNSLLSNATDHLLPFYVNEAGGTGSNGWGENHAALATGTNDMWVVGNTPYSIGYFKREDIPVHFGVADAWTIGDMYQEGVVASTNPNRVIWQSGSINVPGGNVNSTMGPVLDNNDTPGCSSLDLHVINGSTIMSPKNYSCFPYDWKTIPEYLEEAGITWKEYQAVQNFGDNPLVSFELYQNLAATNESAPLAQNGLAMTGSGNWQGGLDDFKRDAAAGTLPAVSYYIGPAELSEHPPFLPRDGGWLWKEMVDAVVNSPKYNRTVLIISFDETGGWGDHVVPFHSPEGTPGEWIVNPFTNNLTFAGPGFRLPFVVVSPWTRGGNVFTEPADHISQNLFLEAWAEARGTPFRSAEINDWRREHMSNLTSIFDWDNPDTSPVELPFAETPHSDLLTSLLDGPQNCERLFGDTIQPPIPYGNQTEEDSLVTEQGFKSVRGALTEGRYLVIESNDSTLALAISTDNTTFIASPASETKFDVPSQRFVIHATDPTVASANTFKISAGADFDGLSSMYITSNLTLGTKDEAAVFDITFLGVTEGYVFEESGSGSGRFLGMTSDGKVGLGDEAVGMKIFAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR63</accession>
    <name>A0A8H5FR63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR63"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29093" checksum="0A6D60E83249E1D8" modified="2022-01-19" version="1">MPHEQDEVDDEARQKAMKDLVQSWMDRLQLISLITTFLASVEAGLLQVTNGGDDNDSIADQVANATLLSALVLHLHASFISFLASFFLVNFKVKEAKREEAKVEASGNPNGVSSGVGTRPSSKGSVLIDMAAKHLTQSPTTASPRGSTSRSDTTWSNQEHNEKKAQHPGASETMQSKIWSANPRLVQVGPYNRTPPIVLLSRCHSLCILFATIGFVLTMIGIVVYSWAQQSKAVGAVTSGFLGLCLLSGLAIARTSREHRGHGDVFTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRL4</accession>
    <name>A0A8H5FRL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D9758_011638</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRL4"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF5347050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="456" mass="49363" checksum="264CE42EB57512BF" modified="2022-01-19" version="1">MLSTRSKLLVIALGYSIDKWGGEVLCVVLSGCHLIGALLMAGSVTNGLDSYALLIVGKMFSAIGGGSLDNAQQRVFGTYFAPGRGFAFSIGFIWCVAELATFGGQSTANIISVNTGHFAWTLWVSAIIGLSSFLCAVALVYLARYLRNTYDVTNQLSRTKHKGYNVGTRRAKFSLSAMRQLPVTFWFIAFFGAFENAGVQSFTAISTAYSQERLKAGAVIGGWVSSFYLLLPACTPPFTGIFLDLYGQRVTFLLISGIMFLISMLSLNFSKTVPGFITSYVFYAIAQAFTPAPQAEIIRNIIPNAEYFATAFAVKKSILQGSIIIVTIASGKIQDDSPTNSLNDALGLWLAYAFICVAIAGVFYVLSFSKSILPAAYLAQVKPSRLIDTVEDIYAKVGPNDGVERTWEEKEAVLKSPVKNGPSRSLVRSVFPLLGFLIIVLGWIFFGLSISWGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FVI9</accession>
    <name>A0A8H5FVI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FVI9"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="39695" checksum="5C5DAE2CB8252A50" modified="2022-01-19" version="1">MEQEGVLHSAQSLKVLFDSTHSNLRIIRNVADLSSHKPEDEPSVPEDIEMRDPAIVSMEVSSQVSYLRKLKFQYLEQNAKDKYVKYIVSDIDDNPPVTDEDNKKLALVNEQKKERLKQAKKQLHEVHSNIRRLAPSVEDDYVQIQKSTARAAELGQKIIDARLALSRLRQTHPQPRLTLDTAQETLDGQIAEMQELQDKIKDVQDKVQSIKQQMKTGSLEVEGLKTQRAEVEKDAKQVKVEEDDTRLAPLYDWFMASLAFHRSIQDLEEMNSVSDNALELKYRLEDVKGEFHSMTVTLIFMPDTRQLASVEIGDTREVGDELAEVIDAHISTNNVRGLLSAILARARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZ98</accession>
    <name>A0A8H5FZ98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000059">
        <property type="protein sequence ID" value="KAF5354449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZ98"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="140"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="493"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5354449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="68850" checksum="49C0F4EADD278DEB" modified="2022-01-19" version="1">MDSEKARLPGYRYGTPVQTRPRQSLWFSRRAFTHLVVLLGFCYWVNQVWRPSVNGFRSAISLAYIPSSSSPWELAAELTTEERNSLEPGTIIWGPCVPAVRNVDCGGIVVPKDHFDPTAGNAIISFGKWKATKSPKKGSIFLNPGGPGGAGTRLVGTEQRGKALAKLLGDDYDLIGFDPRGIGSTVPATRCFPSPVTNALFFANTVIEQGITVPSISNLSSPRLYHGLVEQYRHFISLKQAQGELCRKNMGNELRYMGTATVVRDIDFMTKIMDGEDAKINYWGGSYGSILGAYLVNMLPHRIGYSVIDGIADPVSWSSEPSHKWPHNWLAHSEKTYQIFLKGCSEAGPNICPLTKYKGEPWKNIEARFEDFFDHLALAPLPVADGPRPGFLTSGTARAFLQIFLQQPTWWPLAAQSYASAFAGNGSAIFNMLSLSYSANYDLTRLAVTCLDSPSNKSYPPTPEDLADQALKNLNDVSVHFGVSTGVSEPDGGCEYWPVKGPERFVGPWNASLDIPLLIVSNTADPITPMSSGLLINSLMPNSSTLLIQDGPGHCSVSLPSLCTIKAVRGYFAGQVPKNGTWCDVDVSPFPSEEDNEVLQSMSMEDKELMDAMRTAGDSMVEARFGHTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G134</accession>
    <name>A0A8H5G134_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G134"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5356387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="150" mass="15035" checksum="93DA6A1DAA56356D" modified="2022-01-19" version="1">MSHIAPLSSPRPPFTMPQPKSSTPVSSYTNSSKPPVITMTIPSEPLIPASLLATSDPPPYAEGPQVSGSPLGLGIPPNLIFPGGSSGVGRGTASTGVDASPTAPSGLVTQQPQSKETMSVGGAGDNGALNKGDNTKKGKGRGISGICWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1H7</accession>
    <name>A0A8H5G1H7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000054">
        <property type="protein sequence ID" value="KAF5356568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1H7"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5356568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26711" checksum="5F19FFCAE2C70B90" modified="2022-01-19" version="1">MSSLTFSLARKVAVVTGSSRGIGAAIALRLAEEGAAVVVNYINSSAAAEKIVSTIKAQGKGDAIAIKANVSTTEGAKQLLDESVKAFGKIDALVLNAGIFGMKTLADTDEPFFDAHFNTNVKGPLFAAKHAVDKGMFPAAGGRIVFLSTSLTSNSAVPTNSLVYVMSKGAVEQMSRILARDLASKNITVNTVGPGPTDTDMFREGKPQKLIDTIAAQNPNNRLGTPEEIAAVVAFLASPASQWVTGQNLRVTGGFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5H3</accession>
    <name>A0A8H5G5H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5H3"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5358767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="181" mass="20015" checksum="2F5CE2E2D6512E73" modified="2022-01-19" version="1">MPAPEVVSPSQDARPIVGHVNLMVDTYIANATTEDLRSSIRGLLSSGMPGVASAFTMAARQRLDQVDVDSIPGSRPLFEYGISNDGEPLPTDWLFETLARFKWDSQGEMAKALTVVDSDISQAIQSCKEEMDAGRASDVEEVRVIVQYLRSAVDQSMMDVESWGGEFPFERASFSIEYWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5X4</accession>
    <name>A0A8H5G5X4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5X4"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="369"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5358953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="557" mass="61681" checksum="073C20BB774BDBCB" modified="2022-01-19" version="1">MEGLPSTPSRLTTNPNPPISKKRKSDSDSKGKKKRKSVVTEPGEEVPKKQAADEAAPDANQDSTISTADFLSAIVAAATATADPSNPQQWAAAGQGTWQGGSTISPENIASNAIASCSVHNGLPPNDAVNESILRALQHLDMEQIAGVLKSLSDTDAAMNGTPSFGPGVPPNINAAILATIMNQEPPPVNQVPVSAGKILGKSTSAAQVIEASGSAEDAHLLATKWFSASKLAELAKTRGLVYKKGKFSAIEEQQLNNAIEQYCIARQLTPDQLNETIFPKDDKTRDNAFWSEITAAVPQRPIISIYHHVRRTYHPFKQQGKWTEEEDDKLREAIAAMGQQWEKISLVVGRRAPDCRDRYRNNIVGRENRVTGPWTVEEEEQLTRIVNDMTVNKGGTYDDEVFWTTVAQRMGNRRNRQQCRNKWTDTLSKHVKSEGTEPRWSNQDAYILVHKLDSLRVRDDSEIDWKTLADKDWNLWSPHVLQRRWRTMKKGVKGYEDMTHQEIMEILKVKKTNFDSTPTTGARKRKTKKTVSAETVEGPEVAEGSEVVEGPESVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G602</accession>
    <name>A0A8H5G602_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Orm1 type endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G602"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5358963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26370" checksum="D41A63F5C07E07CB" modified="2022-01-19" version="1">MTSPRPPRLDLSKSSPRMTHRPRRPSIVKVEQVGDRSVEDVLDQNTYVNNNANWVNAKGAWLIHVVLICVGKIIIDTMPGMSTQISWTLVNLLYLALSYLMFHWVTGIPFQSDMHGGAYDDLTLWEQIDDGAQYTPAKKWLFSVPCVLFLASTHYTNYNPWLFAVNFTALFLVLIPKLPQLHRQRVRFLAEDLSGIATPTTASFPPSGSSTPSISKSMSSPVPVIITEEHFQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G807</accession>
    <name>A0A8H5G807_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G807"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5360073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="225" mass="25358" checksum="109E18CC5D643BCE" modified="2022-01-19" version="1">MEGALADIDKYNSQFKLYAKDTGYNDKGLMKYYRKGVPKGLVDRISYLPSQPKNLATLQKAAVKQHMIWVERQTEKALWGKQRGEGGQQNRGLQGMGGSRTRSLEVNAFQNNTPGASSNTKYPPKLTNEEREKMKKEGRCFGCREKGHTTWNCPTFPRTNTTNSNNTAWKPLIRTTTVTIEPSSSKTNTTMKDIAEFTAKIRSLSGEEKEKAAGYLKDLVTQMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAC0</accession>
    <name>A0A8H5GAC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_010312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAC0"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="86"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5361273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="336" mass="36513" checksum="90A9ADDCFECD24E6" modified="2022-01-19" version="1">MQQEIKTGLLSICARTRGIEEYKSGDGAGGKLITPSHLLPPIPTPPTMMKLLALVSLLPALLGPVSSHAVYARQYDTAPTTGDGGDDHGFQAPGPNDARGPCPGLNTLANHGYLPRDGKNITIPVVLQAVLDGFNVGPDVVTVAAKGALIAAETPDFFNLEEIALHETFEHDISLSREDFNVDPNNDNIHFNETVFTTLANSNPGVDYYNATSAGFVQKERQAIQNAVNPQLINNVKGFKIRTRESSLYVAVMGNITDEVATRAPKNYVQILFREERLPIAEGWKKNELMITADTIRPIQKEIERLSEFQPSGVQPNPWIRLGPSGDIDPITANSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAC9</accession>
    <name>A0A8H5GAC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAC9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="38" mass="4279" checksum="23777E48E8C610DE" modified="2022-01-19" version="1">MQDAERKGPRSEFCGLLIGYPIIYLHELPVVPDAIHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAS2</accession>
    <name>A0A8H5GAS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_006159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAS2"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="49"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5361534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="212" mass="24100" checksum="5CE155E28FB6469E" modified="2022-01-19" version="1">MEKMRQRFMPEYQENVAFQRQSQDAKPKKYRTRRSRSKSDDDDDEARIGHVEGVKIGQVFEKRKDLSDAGVHTPLYAGISGNSKHGAFSIVVSGKYEDDIDEGDTIYYTGAGGRVDSFGNSGPQTEDQSFEHLQNKWLLMSWELGTSVRVSRGSGGHSKYAPTTGYRYDGLYDVVDREHIKGKSGFKICRFTLKRHVEADRISRSGEYRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GB30</accession>
    <name>A0A8H5GB30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GB30"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="72" mass="7724" checksum="08D95B0D4CD000DD" modified="2022-01-19" version="1">MELVVQVGFVVRCVLVGICILGTSRTHSCTLPANSLANVVVICKGVFSSFSEFVWISGLPLFSTLQLSTSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGS6</accession>
    <name>A0A8H5GGS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_009371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="703"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5364789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1571" mass="179327" checksum="D78D937562EE9323" modified="2022-01-19" version="1">MREEGDLVIRAIRDDKVFELIPHHNFEGDLPLRFVQDYYTCIDYLMAKSSCVLSRACGNETSTVTFEMVQATLKPLERKEYLTVTCSNDFNPSSLAVDLPRYRLAFHRNDKDELESRNFPGMIVDHDDQSFGALVGLQNRLVLRPNNRSLAGARRKVLVPYGNVEISPYLDDHVTVTIDNKDDRIIRFADYVVDVEQGCLTGNTSLRSRLFLIYLLAVTSHCLPDPLTKVTGVEEALSEFHTAACMSSRELTEEDMDLLVKIGKLTPSRFGVPPSCPKVQSITWHPSLPPLSQHDAFIVRAKEIIASAEHQRVFDDEAKPQSEQNMKGKDKKDGLPARNHHVDSRAAARNAVYYPSDFAGAPQRRTYDLSYSSRDTQLLLETVVCSAASNVFLGPTYCLADKPRPLHHLFKRWARLRQPSKSFRLSYNRGWFSLNFADSWLSIYEKCIKSGSRDRKKYRLLFSLSAMVFANPQHSCFVAPIVFSFWDQTLRQQHVPHSVEFLFDLDQGIAPTDLKLASLITPAALPAEATPSWNLERLADEEDRDYDIRRRQHYHRRCKDFSVLLNNFFLGQWGDFMTHRLDITFNPNVSRSYYRVESLIANVQNYFNICNQNRLLINHARAVNSVFDTYFANTISYDVPEYDFQPCKDNVPSSSSSISLTGLLSRNAPALPQRDAQLWGNPDDFRNGTHPLSQLSSRSYSTRYRSVAESLAKSQRWLDIALSDVLDESDEILHIRYQLVYTVGQQQPLELHPDRWTIMEELYNGRLSSFNVRFLPETVQVLARAFVENPKVELEVVEELKEYCGRGNDWKHLLLLRGLIAHGILLYSLKARQYRVDYGLDLSRSLLAVPYRAKDVPSIRAEFGHPDVALALTCLTYYYQGLDSAQLKICFDLLFKLDNPPLEYESWVDDDEAIPIHSSDAEWLVFPKAAKEFPFKLSTSSWDLAEAKPRHLTTGFSGTNDNRFLLPTSISQRDPLQQSGTNAKVLTYLLQKENNHYHCAALPDGGRLPVVQFLEFMSQKTANQVVQVLLDVGAQMLDLKNEELAKEWLRLRPEMLACIFFSEKDELMVVTQDGTVETLISSPFKGQLDHCLVYLDDAHTRGTDLKLPINSRAAVTLGPKVTKDRLIQGAMRMRKLGYGQLRATPASHPIHVEDILRWTIFETCRDIQHHLPHWAEQGLDYLRRRQAWEEFSNEIVAADESEEEEITPNIDILQKVWVREEARTLEKMYDVRTGPGTTGVGGGDANLRQGVFSVPELRERLKSLGVNEVADVDVDEEQEREVNHEIEQETEIERPLKVEPAKHHLSHGLPIFVETGVLPFNGTGPEYRKGFQAVYESIENVLRRVPLIGVEGKAVWSPGLYATKDFSTTISERDVVERGSADYLRPVAFLLTSNKYEPNGVVVILSPFEVHHLLPAIRRSKHVHLHVYSPRVTKDMLPLDDLRFYVVPQLPAEPWNPPRVNIISQLNLFAGQLYLGNYDVYLSLCRFLGLHNGEEEPMEIDDEPYPVQSDGFVRVGPHRESMGLKDCRFNESPVPFLQELIGLRRKGMGYLPTHLGRIVHGRLLTADDFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGW6</accession>
    <name>A0A8H5GGW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGW6"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="2">
        <location>
            <begin position="500"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="567" mass="63049" checksum="420405AB57B0891D" modified="2022-01-19" version="1">MHSTTPATTRNNSKAGGAPLVPEYQDSSTSDTSPSPNDLLLTKTLPDESTSEEDTSTKSNDQEPSSKSPDQDPPRPKSPPHRPKSPSSDSSDSDSEPTMSSNMPTAAWTPPDYGKLPKVHVCPVEPHDYTGIMTSIAYYFSAKGISDTKTEQARNAIASCFHAPESHDFFNSGRTRLLALSEAEYQRELIEHLLGINWVDKVAKLRGAVNQSEVCDQSFSALLEKIVAYNDMLKDTPRYLSNAQLQELKDDMEYSAWVKVVKTFDKAYRAVEKPKMDQVNALQLRIAELEKEKGQKRANTSSHYSNDQSRSRPFTDYRHNASAALSAGSSSSSGKLLPTRMRDIFENKEQKQIYMDGEICTRCRNWFAGHRGNQCSTSCNLSVPYCDLTKNDLVLAKQIHQRSKAPITMDAVLKYKSNAVAAVIPETSSAPIEDIDAFLNDQYSSIKDCSALDDWVAAGGLTEAIEAIINNPTLMLQSLANRLPGASVFFLSYMVTQGMTLRQVFAVTFRMPSIDFGETLPQLSLLATITFAYSVLNPLINFLAFVSYIMMYIACKFFDQQQLWLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH61</accession>
    <name>A0A8H5GH61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH61"/>
    <dbReference type="OrthoDB" id="3203775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="71"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="206" mass="22898" checksum="B519A8AC551CD181" modified="2022-01-19" version="1">MIRILVKITVFAALACDMLAIIADCADVYLKMLASTLYLTTLHTSSYFQSQNKILSSQVVYVAVILWLSTAMVADLLIALLLVLYYRVTERHRTIKSSSKLVRRLAALALKTGSFTALTAVLTLDIDNYLALFLLNFWIEVNSVFGFCISSIYSLTFLYNLNIRRKLINRTNSDDVGYIRIPDLEVAGTGNGGGHLECGIEVAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHT6</accession>
    <name>A0A8H5GHT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHT6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51781" checksum="9517EA54FB434DB7" modified="2022-01-19" version="1">MPNIFSRQPMPKAEDAIPSGLDWGHAKTILSLAGSVRKTAGVPYLEGAAEIAIKIIEIVETMKKNKEDCVSIARDITDLLDGIKDIMERRKDIKQNEMLIKNVQKLENDLSIIKDKLHKISNRKTKFHVTSDAGIIKECREKIKNYMDVFNTKASVNIWKNTGELLQGHEDIKKGQEDTRADTREFLQGQDDIKGGLKEVMAGIAKTHDQSTITYDDLEKATPAVPPVFFGRDKLVSEGVHHLINNNKAFLATLGARGIGRTSIALHINNAPEVKKKYEKASYFLPCEVLSNTNLLLQGLIQRLDIEVGQGESQHKKLEDYFRINTQSILLILDNFETPWNNDQMGIENLLGKLASFDQISTIVTMRGSKGPGSIYWKRLGSESIPPLSLESAKRVFLEISGKEQLDEENDIVETISKELDCVPLAITLGYYPYCKESCSFPSQITPENVAKRQNKNSQAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJK5</accession>
    <name>A0A8H5GJK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJK5"/>
    <dbReference type="OrthoDB" id="2604709at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="236" mass="25836" checksum="5A716288338DC9BE" modified="2022-01-19" version="1">MDVDMNNSSTAHATFDLSTAPKPGLYGNLTPASFSSPIRAPSFAFGPTTLTKPGAGKIRIPSLEERQKIATMREVFGEDDEGYDVSNWYELGYDEEDLRYFEPVKASEQETNQYLNSLGWPPQRPVMKRKIAGSRRLLSAQTNSKDPRIRAQAFNDLAKLSVSTPSTPSRDRVCQAQPGFNSPQGGRGNNDWPGVSRTVSYGNGSTYDGGATLPPPFQAQYQLVPCDSEDVEMGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKK8</accession>
    <name>A0A8H5GKK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKK8"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40746" checksum="7B4CD07D6FBC88D2" modified="2022-01-19" version="1">MSSSPPTGLESNTATTTTNAAHPTLESKTTSSTSNKKGDASATLNCNTQEIGLDDLDVAAWVLSKAFLDDRSVAYYGDCEAYPTTRESPNGMKIYFFFRMIMKAALLKGGRVVVATTTTPDTIAGTKCKDRELRPSPEQGGDKRINLESDERTKLKNGETIVGVACWWPPHKRLPVHNLPLMLRCGAWRYLKGWGLTGFKRTAIEYSGLSERTHAAAFESHAKKDKDNAYAEGNGKGKKAKALKPHDCWYLNIVMTVKEFEGQGVLSGLIREAYKHAQNTNLAPFILEAMTERSRDRYTHLGFEVEPDQPPTILGAGKVNETGLKVKTTRKSAGSSASREASDEKDVETASVSRKADGVEVYCMVNWNPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL16</accession>
    <name>A0A8H5GL16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_004070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL16"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034277873" description="chitinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="28"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5367039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="496" mass="51560" checksum="D884B69103DBC6EC" modified="2022-01-19" version="1">MKFSLIASSSLPLLIVSLVSAFDPNRNDNLAVYYGQNSYGATHSDTANWQTNLAHYCQDDTINAFPLAFLNVFFGPGGLPEINLANTCNNVDDPVFPGSTLPNCQFMAADIQACQARGKIITLSLGGATGAAVFSSDAQAQSFADQIWNLFLGGSSSTRPFGSAVLDGVDLDIEGGGGTGLAAFVTRIRSHASGASKPYYVTAAPQCPFPDGNLGSVLNAVGFDAVYVQFYNNFCGLTNFNNPNAWNFAQWDTWAKTQSPNRNVKVYIGAPASSTAAGSGFVDAATFANIIQQTKAQFSSFGGAMLWDASQAFANNRYDISVKNALTGGTSVPPPPTTSVPGTTTRPTTSPTSVPTSIPTNGNCQGVSAWQSSVAYNGGSLVTFNGHLWQNKWWSEADQPGGAAQVWNDLGACTSSRVSTVPEAATLSASAPARSVTSGSAKAVKASATAAPALIASDSTVKASKTADVASDTKASATSEAAGTTSNTKMSRFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLY0</accession>
    <name>A0A8H5GLY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLY0"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5367441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="314" mass="35808" checksum="960BF10C60A5FC4E" modified="2022-01-19" version="1">MLSFAFSTASTYFHLPVDEDEDKDIQSYQRKYLTWRTGTSTSSPSQTSPHIQQDSDPHFDTAKNEILEHVLASEDLYKVLGISETANLDRVSLRRAYLLRSRACHPDKFPHDKENATLAFQKVAVAYDVLSKPSSKRLYDHRSPYSPYNAFAARPTGHAEETFRGAVIAVFNDFLEGDLEVIRNLLKTTSDLNPSLRLGDEGVESVITALQSIRERALTCRTCIYALHAELSRLIEVQHALRQLSYLDVFGRSRLSIQFTRITLCLPIALERALEEQNRMYGYRQDTVTLLPRHLSLLIRSIDIALERVEGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLZ9</accession>
    <name>A0A8H5GLZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLZ9"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39949" checksum="05E2199C4F029BE8" modified="2022-01-19" version="1">MGLFDVFRGIFRTDYYEKMPMSVQLQWNRTKKKRLLVIAAWTLVVLIILLILGAFVSYKGPLLRSSESSDRHAVFTTLYSNSFALGAAVLGHSVRRANVNAKLVLLYLDDNRVSPQALCITEAAGWENHAVSLIPPPHDGDGIDNRFSDQYTKLRIWSVGEVLGYDRAVYLDADTLVRRNFDELFDIPWEFGATTDVYLDERKFAITFNAGVLAFKPSMRTFDDMVSKLETTDFPRKEAEQAFLNVYYRTNMVRLPYAYNANVATKYTDGDMWNELKETMKVIHYTLVKPFWEPSVANDNLTTPDQIREINDAHGAGGWWREEVGWWRESFEDLMKQKGAIIQACYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GN83</accession>
    <name>A0A8H5GN83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GN83"/>
    <dbReference type="OrthoDB" id="3058010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="65590" checksum="94461D8FFD3A8205" modified="2022-01-19" version="1">MSVEGARRARQPPQPPAPVQTHDHPMASVVRFSSPPAEDQLRAQAGSPGHHVVDVDINGTEPSASELSLSYGADPRAKLPFRKRVRRSIRRVFEEIWADALFFRLPAMYKERVSQAAMGCGCLDKGKSRVRNWTRTRRGAKSSRLSGYRPGGLEETGETETENETDTEIDHVYGGKQVFRASRTSQLSHGASRESVNTFGDWDCRAGSYWDGLVGDLLQEWKTTGIGAGLVIVASLLLLQLTPTDIITRTGCVFSFICAATSLLSAIACMVRFSGMRMEGKATILAQKSLEKDYVIWWNIWIAISVPLTWSIWSLVLLLTSAMTFTWRSTAGSSLSSIGASVTDTVLPFRVVLGIRVGVSALLGLGVLSVMMMLVTLDRLKGREVMSERPVSVPALGGRVGRGHARGRPDSQSSDDDQQFVSRVSRDITTITPQAQPEQPRNQTGDSEPRVVFPTLTPGSAAHIQNAPEASASSPEPQGSSPQGPLSPYLSSSSDVPAHPSRSDPSLPARIGQVQGKGKRTVSTSQLVGVPVTSSSNASSGSKGNVSKSAVSGKSTGSGSGAGKRSGQSGQTAQRQSHSRKSSAASVARPKRQSRTTSTQSRTAQGTSHSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ32</accession>
    <name>A0A8H5GQ32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_002968</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQ32"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000327">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000639">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="58"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="453"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="694"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5368924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="737" mass="86949" checksum="7B0EC698280B49A5" modified="2022-01-19" version="1">MDGRAPRVKNRAPAAIQITAEQLLREAQERQESAFRAPKQRVEDFEELHEYRGRKRKEFEERIRRTRGSIKEWLQYANWEASQNEFARSRSVFERALDVDPRSIQLWFSYTEMELKSRNVQHARNLFDRAVTLLPRVDQLWYKYVYLEELLQNIPGARQVFERWMQWEPDDKAWQAYIKMEERYQELDRASAIYERWIAVRPEPRVWVKWAKFEEERARLDKAREVFQTALEFFGDDKEQIEKAQAVFSAFAKMETRLKEYDRARVIYKFALERIPRSQSVALYAAYTKFEKQHGTRTTLESTVLGKRRIEYEEELLHDGRNYDVWFDYARLEEGALKDLRDDGATAEEEEASMGRVREVYERAVAQVPPGNEKRHWRRYIFLWLDYALFEEIETKDYDRARQIYQTAISIVPHKVFTFAKLWLLFAKFEIRRLELGSARKILGTAIGMCPKEKLFKGYIELEVELREFDRARKLYEKYIEFDSANASAWIKFAELESQLQDFARTRAIFELAVSQSPLSMPELLWKAYIDFEVEEGEREAARTLYDRLVQLSGHVKVWISYALFEAEAMPLPRAEREEEEEEEDEEAEQKMVPGDPDRARAVFERAYKDLKGKGLKSERVALLEVWKTFEENQGSEEGVKKVQNMMPVVSKKRHVDEETGQTVEDWELVFADDERESNPSTFMFMKMAHAWNAQRAQKTANDTDSSSSKMLSGFVAASKPAQDDATSDVASSHGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQ49</accession>
    <name>A0A8H5GQ49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_003038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="73"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="905"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1334"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1365"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5368830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1377" mass="155653" checksum="7F06F81A1B5C5DCD" modified="2022-01-19" version="1">MDANFELGAAVEQLSDPSNIDLEHDHDVTNEDVDRLLEDAVEAVAESSENITTPQTFGIYCSLLKYSDSISGAVMSKLLDSISSGMQSEYETTVADIGRGDDYQRHKMPLEMYAFLLQWFVRSAEKVRSDDGEGAPASAAPKAKRGRGGRAGTGRGGGRSAAAKKQTEQWTWIDQIPATLEMIKKALAKLQTATPRLWTTTTERETFISCLTRSAYFIAENPAYIKVNEIKDRVYRIICMAVKHHNHGLTAQILIMQFLQFYEHLAEPMAECLSMLAREFDHPQLGDEILREISQKSFAANDNKVSKAFGAFLVKYSERAPRAMIKQLSLVLKQLDSEAYHLRVAVVEIMGIIILDLSDSLSSDASEDVHDRKQTENQIKGLYELLLERMNDVSAFVRTKVLQVCIKLCDAKKKFPKHRLAMTNAAVAALEDKSPSVRKPAISLLVQLMCTHPYGMVHGGTLEKSLFKKEFEEVEAEFEKVEAQMRTAMGADAEEPEEEDEEGKKKKKKKRRKSGEDMNVDADETQEPTDDEDSDEEDEEEEENDDDNDQAGDEDPDSMAVDDEDGEQQNPKPKKKKKSQLKPRKSQIDLNALNQQPIDAGAYEQLRLRKKYYSDALQFIRIVEESMNIICQLLGSTHKPEVLESIEFFRVADEYNFESAAMGLKKMLHLVWHKDNNATVSEDGQQLKGIPSRLLECYRSLYFDPVPDLEPKDQVNRIAKNMIQLTFEATLAELTSLEEMMRIMMEDNQIHHDVINKLWQVFGSDRVLPKAQRRGAIVILGMLASARRSVLTDRVDTMLKVGLGALGKNDLTLARYTCLALQRLNGSAKKVKGSLQDKTLRIEMENNIFRKMRIAIERPCRSKDWFGLAEQAINTIYALGEHPDLLCNDIIKTLTLRVFAKKAASKEPAEEQSAPKDPDAMDEDRPAEETRNEPGQSQEPVAEKDQADAFELSQLLFVVGHVAIKQIVYLELVERELKRQKDEMQAAEKQARAGAPAPKDGEELDQVAGNAEDEIADRIQEVRENELLFGDHSLLKMYGPMLVHIASSPKKFKNPTLRAAAMLSLSKFLCVSSKFCEQHHWLLYEVFKASKSANIRSNISIALGDVAVSFSTIIDENSHELYKGLTDSDPGVKKNTLMVLTHLILNGMVKVKGQLGEMAKCLEDEDPRIADLAKLFFTELATKDNAIYNNLPDIISHLSTGDHAVDEDTFQSTLKYIFKFIEKEKQAENIVEKLCQRFRLSEDPRQWRDIAFCLSLLQYKSERTIKKLTEGIPFYRDKLHEKGVYDKFTEILTKAKGTKFGTKDLTQELNDFEQMLEEHRRQGEDDHALEKRAQGKKAKAKKKAATRKTTRTRKVPTKQEKESDAEMDEGDAGDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQC5</accession>
    <name>A0A8H5GQC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQC5"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15256" checksum="5893D4020AF9B71E" modified="2022-01-19" version="1">MSIYKIVPSSPAISLTTASEGHKTLDPSFLLLSSALDTKDGFIHMSTSSQVPQTLKRFFPTSTSNRDSIYLFKVSYDDVTKRDDVEIKWETPEGKSAEPWIEERGFPHIYLKGQDGGDGYGLAVFGGTQAKGVVCAAECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQY3</accession>
    <name>A0A8H5GQY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_002684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQY3"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="223"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="42783" checksum="92C61836408B326E" modified="2022-01-19" version="1">MSFQDSLAKLNSPVKDLVQSVAQKEYALEGKTDEDKDEVVKWIDKVAKGDVIKAENFKSLDATLVPQTYIATNYLTAADVAMYGALHPVISKLPPQEHFSHPSVTRYFDHIQSSPLVRESADSTSSFPVVSFDFSNAPKLERPAEAPKKKEKAPKDANAPSTSAAAANPEAKSTDAEGSKKEKKEKKEKNKDKAVAGADAGAKKDGKKAGGKNAPAADEGEPVPSMIDLRVGHILDVQKHPDADGLYIEQIDLGEETGPRTVVSGLVNYIPIEQMRDKYLVAVCNLKPASMRGVKSFAMVLCATSKEGKEGGIELVQPPANSKPGDRVYFEGAEFENATPLSQLNPKKKIFETIQPGFITLDSREAAWVNPATKSVHRIRTKAAVCVAPTLVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRG7</accession>
    <name>A0A8H5GRG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRG7"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5369565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="375" mass="39591" checksum="F33E43EF46E142E4" modified="2022-01-19" version="1">MSISASVSHAFSASNPDWQHEEHETNSEEDAEEIEEEEEDEVDQLVDESISEPEEPTEEDSSVKEPGRLPGQTLLPAVRLENIMQADGVTGSLSLSREGMFVLSVATSSKQEEFIKRLTQGGHREAIAEGRSSIHYADMAILPPPMSLADALELREARLKDIRDEDPSLSTLSITATPGQHSPNFDRLYTSLSNSKPKKNRSTNGKEKVNGAVSSANASGMSSVHESATPALPASNSGSGPQGWRSGPMLDARPWSHWADTAEGSSSNSHDDSHHPALGVNGSQSFALANGAPSIARPGTATGTATPSVPPTSSSSPSVTRDSRPESVSPVNSTTSDQQGQFTGPGSSYLQGPGGPSPFSRTGADQGRTIYSQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRN4</accession>
    <name>A0A8H5GRN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRN4"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="34"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="441" mass="49108" checksum="29FD34E850619240" modified="2022-01-19" version="1">MKAEYQRRGLKRKRNEPSREVPQKDIGTKVVGKLHHDLKEVRKAAKKAKTFETQKLVKKLKNLRLKEGSEHDINECQTQLEQLKVLSHDAVANTALRRRLTKDKVLSENESMQTALNQELSSNLLTPANDGTPASKIQNRLLSSKILAAGVSSAVEDLRAVVRPVDDSHDGDVSVDDELSERPRKLKKFDGKSLSASMEPGDGDVEMDLGGGGMRVGRSEQLDDEDVDAGGWESGTVGDDEREPGNDWESTSLIDDDSLDGYMDEDTPDVEDEKVMKQQSAKAGASKSHTREGQSTFLSSLSTGFVRGASDSDWSESEAKIADFGQKKNRRGQRARRAIWEKKYGRNANHKKKEATEIAEHGRKRWPGQASERRNHRGQSSQVSTTNSQSRQKAPQRELPRNESSATGSKPLHPSWEAKKRLKEKESIGIQPPPGRKIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GS91</accession>
    <name>A0A8H5GS91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GS91"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="320" mass="35248" checksum="2F92901CF510D7A0" modified="2022-01-19" version="1">MSLNRLPPEIHDILCLHLPSSHLAALSLSCSHFYNIVQRHLYRDIHITPAFHNLAVVPTLAAKPALARHVRSFSISLASQSSVLLAYYRQLARALSHMTGLSSLSLFVDPSASWVLRGVQAKWLAAFACSFPFDSHVAAFLKTTPALLRLEVDPESQAYFNPEDASIIPHLEQFRGSSQVAQAIVPGRPVHSVFITSGELTDVVAHLADSVSNVSILEATISSSPAPLLHLISERLPHVTHLRITYNSSEAPDTAFYEDVGSALDAFPRLQTFEFSGMHWGSLKNNEISSEQNSSELQQTDAPSFETIDVDIDSEFFTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU28</accession>
    <name>A0A8H5GU28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU28"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="68210" checksum="CCA9FDF3927C96CA" modified="2022-01-19" version="1">MKDISKDSLVGVSVSVDFKPHLVDLYNATADRKDGDAMYQAYQTMIDQAEQVYGCTIVTLGTDNDGGSKAGHAKLEDVRLWLFVFPCGAHQGQLVFGDYFEACPESAQTSEEATALIGWLNNHSYVRVIFDQVQQEKTGTVLKYLVANLTRWTTHSISFTRLDGVRKSLENAAYNQHDEIISAQVGKETGSKGIALHEEAEEQLELIQNKDFWRLINDLEPICYATNICQSDHARPDIVLLALVGMFLYFRNLPASRSQLSQEMQKQLEQRWKGFDQHLMITALILNPYEFISCFGPKAELDIIQAHLLIIELFDKWIDRPLLDKDSDEQEEILEDWQCQRKELSTAFIHYFAHTGPFKNWDDLKAQLEDIHDADPILFWECMKTNLLVSVLAEFAIMILSIVMNTAVNERHFFPSQDYKGSFAKSSRASESPKENQICFYADGLRDIRDPRKNHSEEHVQTLLEVPRYDHILSTPHDFTDGHSLLVNTRKKWRNELAKWIEQARDFDEDSDDNSIPPPLPESSNQCCKWLPRSLELLFGGAATEDQSSESVEGPRRTRRRNFTEESLLMELLQQEAEDEIPDDGELPGSGDEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUU5</accession>
    <name>A0A8H5GUU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUU5"/>
    <dbReference type="OrthoDB" id="2803656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="373" mass="40285" checksum="172DE2AF7370ACBC" modified="2022-01-19" version="1">MSTATDTNGTSSSDPLQVAAQLYPWMYMTSTLEACFKTAEETANKELDERAKSLEAGEADVSDQQVRMEAERTIEFYDELSSDKFATVAPKIMQSFLSHGDACTKLESEALQLASKDLSHINLDDYENHPMQPYNDMLEQLGKSPSFMSSCPESLLGQASELETTILDLTTTTTGNSSESHEAQVFSESNQNLDSGPKSEQNQMPNPESGSTQGEDQSTSVSPQNPESQSESTSPSSSHTTNTTAAKPSNSESTAATPSESLAMAESESTAARSQLIPVFTTCLPILRARKANIAMAQQLVEGAKEMLGMTLHLESLGFEDGDDADKSEVDEDEDERRGDGEHVVVNGNELVVGDGYRQSRPGGNSSDEEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV28</accession>
    <name>A0A8H5GV28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT superfamily oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV28"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5371806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="91700" checksum="3F6569891753D31B" modified="2022-01-19" version="1">MSVMEGSPTPTLPTLQHSRSRSDSKSNSLAEKEKEPYEALTVADPVDDIVDTHVIQKAEDVSTHILFTRDDPDCPIITFRSIFLGFGLSAFSSVLATIYTFKPQNNTVSQLFCLVLSYVLGTAMQASIPTKGLWRYVNPGPFNIKEHTAIVIMSSTASQVSTTMEVIAALGKYALAYFQGFSDRWLVDLFYDIRLNTAVAMFQIFATQMIGYGVAGLLRTFLVYPTYAFYPTYISVANLLQSLHFGGALNAKRRKFFWIMFAAIFFWEWIPQYPFPLLTAVSIICLVDNGRSSFVRNLFGAGSSNEGLGLFSFGFSWSLITQGYPLVWPLRTQINSYLGMVLGYIVLTTCYYSNIFGGRDIQFMSTSLFSANGSTYDQTSVLTSDYKLNKSAIAEVGLPRYTTTFAISQLSYNMSLGAAVTSLFLWNWPELKKGVYTGMWIRAFGGMAFLKRGHADVDDPHYLEMKKYPEVPQYVYGLVFLISMAVGIGCSYATPTGVVLIPWWSVIFFTGPYSFLSASVVISSIQHLRLTCLLYAMVVFAFIISIFLGFVTATTGFNLSIKYAVQIIASFIHPGRPITVMYASLYGNASAFQTLYMLQDLKLGQYTKLPPRMTFTFQMAGSIVGSIFNWTMMHSIVSSHREVLRDPVGTRVWSGWNIQSLNSAAIAMGAFGHELFTHGKMYWMLPFGMFLGLFAPIPFWIVYKLAKPESRLARCAKYFHMPVLLLYMGYLPYSVNGQWWSCFVIGMISQWYLRTRRPKWFAKYNYLLSAALDGGSQVILFILSFAVFGAGGHAVAFPFWWGNPENMSADRCKLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GW81</accession>
    <name>A0A8H5GW81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cellulose-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GW81"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712542" description="Cellulose-binding protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="403"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5372122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57957" checksum="F9CA91FB9C6DD126" modified="2022-01-19" version="1">MTQLKSLLWVFAAFFGFSLAVTKPRVFVLTDIANEPDDAMSLTRFLVYSNQFDVQGICATTSVWLQNQTRIDQIQDHITEYDKIYDNLSAHQPDTEGPWPTAEELFAKTYTGLPLYGLEAVGEGKSSNGSIALRTAVEASEEVTWVLLWGGGNVLAQAVWEYEQNHTITEVEHFISKLRVYSISDQDDSSPSLRRRHPQIFWIYSNHAMNVYNTATWTGISGEILYKFDEGGPDSSIVTNDWLQTNIRDVSSFGSTYPEFAFIMEGMVILRLSYTSFKMVWVRGSIRTGAGKSPTQIILPSKVVDLDISRSWGGRYGRVTNQDHLFTDTVDTDVLGVNDANYTSQHVTIWRWRDAYQWDFSARMRWTNTSDFSAVNHNPVVVVNDSKIVSEALHLNVAPGQTLFLDASASYDPDVNGSSTAESIDSKGFANATFWQYLDASSSQRDIDSAPKLRIVQDGLTATVQVPVLDDIPTAWIQGRGANFDDKTLHLVVEVWDQGTPSLVGYKRVVFDVQVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWG4</accession>
    <name>A0A8H5GWG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWG4"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712540" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="560" mass="59010" checksum="11B41B70CD0B70E8" modified="2022-01-19" version="1">MFGLSRWMVLGYWVSVTVHGLVQPRGPVDVVEGLTGKPALPDLYEASVLDLQDGLDAGLFTSVDLIKAYFARIDEVNLKGPELRAVIETNPSAIMQAAAMDAERKAKGKRGLLHGIPILLKDNIATVAVEGMNTTAGSFSLLKSVVPDDAGVVKRLRKAGAIILGKANLSEFAHFRGNVASGWSGRGGQGTGAYFPSADPCGSSSGSGVAASIGLVAVTLGTETDGSITCPTSQNNLAGIKPTVGLTSRAGVIPISSNQDTVGPIVRSVTDAAIVLSVIAGKDPNDNFTLAQPDVVPDYTRALKKDALAGKRIGVPRKFFLDVPNIIDETVAAAFESALETIKELGATVVDPADLPSAEEFLASNNETIVLDVDFKIELNAWFESLVENPSGVRSLADLIAFNDANPELEEPTNFTDQSELIESQATSGKDAAYFQALAFDHELGRTRGIDAALQHFRLDALVLPAPGFTTSPAAVAGYPIITVPLGFYPDNTTIQSAGPLTVYPAPGVPFGLSFLGTAFTEFNLIGFAFAYEQKTHTRLARKAFPEAIPKTQLANVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZZ7</accession>
    <name>A0A8H5GZZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZZ7"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5374329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="257" mass="27139" checksum="18C55B585049F142" modified="2022-01-19" version="1">MLNGTGYASSVTIGILVGRTDLSRSSSFASRCHLPPSPSLILLPSFVRCPSAALQGAFAEYQTALEKLHLRDVGVKVRVVLVRTNEDLDICHALIIPGGESTTISIDAQRSGLFQPLKDFIHIQRKPVWGTCADGRTRVVGWDGGGGWEEWVGVAVSGLRDSETPFIGMFICAPVILSFDQPSQPSPSFSPSPLSSSPPPPPIRIIARLSPDAVLHASGLPLPLPQPVPVPTPSTSSSASPSIPNSHPDADAGPDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0G9</accession>
    <name>A0A8H5H0G9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor 3B subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0G9"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034725811" description="Splicing factor 3B subunit 5" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15302" checksum="18F8105ED4CB6295" modified="2022-01-19" version="1">MTMTWAITCSWFFIFLLPSSDTSAAAWRWFPNMTIPKSKRFFVNSSFKSSELRYTANTQLEHLHARYTGTGHADLTKYEWLTHQHRDTLSSIVGHPTLTSFLAIADGESAGRVKFEMAEKMLQPCGPPPRKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0V3</accession>
    <name>A0A8H5H0V3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0V3"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50982" checksum="BDEFBBC3ECD62450" modified="2022-01-19" version="1">MAELRSPGLLESYHLVSHGLGMDSCVLSAAKYVHPDPDIFSLCQQLLFPALHSIIPQHPILCVRASDARVSPIHFIRMDTIDLSKIVRYLDQSSQHLEEVIESELTKPFDTTRDVPLWRLTVLNDNTIIFAFHHGIGDGMSGLAFHRTLLRTLRAQNQKPDSFIQKVFVPKDITLVGASDQLTDVSSSWSQVIRAVLDLFIPSPWTSAAKSWTGNDVPVQIPPLQAHARIIQVAARDAQRLLDVCRAHEATITSALHSLMISSLSNILQNSSYLPLVTNKSTLFSGIPVSLRFQTGVSKDAICNHLSMIFVTSPIQPQFSWSEASALATTLRTKSRTCKSEVGLLRFLFGNYAGFLKGNLGKKRQTTLELSNIGRFELDDHEDDNEKRGPSWEIQDLVFAHCNVTMGAAIKLNVASAPSGNMAICVTWGDCTVDSQLVDMFIERLKHQISDLVEGSVPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H118</accession>
    <name>A0A8H5H118_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H118"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="239" mass="26982" checksum="6E880DD7CA8FF354" modified="2022-01-19" version="1">MDFTLTTISPSDGFSKCRNKFYSSRAIDSFLNIVESNKKGKEKLKEWMMEKQRAFDLVVTLVSEEMEGLKGYMKLNMNEVTSEFLEKFCITEVTQKFDEASPTVHHILQAACQTEHAAHENTLKTPELVSPSRYILDDVELMIPQVPYTYSITTLLNYPTTWSANQCPRRTPETGPQFEQTTMELQPNPLSPMDLIVNKPVRMIHSRKAVCDGGGGPLGHPKIYINLDQPGPCACQCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHJ3</accession>
    <name>A0A8H5LHJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_005902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHJ3"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="262"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5357367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="502" mass="55964" checksum="22BBAAB7BD79EC59" modified="2022-01-19" version="1">MKDHVNMFGGSPLNRLSWLRSSPSFLNGLIGSPKTRFLLFNAGQPLLLTKAPDFAQNAGTLAFLSVNQVKPFLGQEPYFNQAKTPGELISKEEETSFTEAARHRGLPLVFLGLHEPQSDHGHGALPSSEFSSKSTDAANVIAKIEGTPYFSFDVADLELSEEEMTRILTETGATNDEQKLIWSDARAVMSTMSSFEGAVYAEARSMVDWNWRNKFCPGCGSPQYSLWGGWKITCSSLLPWADNSNRKRPCPSGKGLQNYAHPRTDGVVIMCTVDRSGDKILLGRSRKFPFKFFSALAGFIEPGETFEDAVSRELWEEAGIQIYPNSVVYHSGQPWPYPANLMCGFYARADERKEVRVDLDNELVEAKWYTREDVLEILNWGKEGEGTKIEWKKVSEAEKKAEDEQQKVMAQARARAQAQGQGEGKKEGEILSVWTENKDHQDVVEDKEKGKEKGKGKDEPPFRIPPTTAIAGVLIRDWAVGKVKFEPIEGDGEELVAKISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LLE0</accession>
    <name>A0A8H5LLE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LLE0"/>
    <dbReference type="OrthoDB" id="2634466at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="952" mass="107338" checksum="B2373735116738F3" modified="2022-01-19" version="1">MVADEDVNKIWEIYIGEARRYDEKLLEGWKSDMDGILLFSALYSASLTAFIIESYKNLQDNPADNVVALLAQISQQLSAVANGTTLSVQGSPAFEPSPPSLICNVLWFLSLVLALSCSLLATFVQQWTQDFISKTHLKPSPFRQARAISFLYGGLRQFEMHTFVDVIPILLHISLFFLAGLVSFLVPVNRLLAYVMASFLGIFLSIYIGLTVLPLMHLNAPYRTPLSGPLWRLGSILGIFLACRHGLHPTDQTLSEAMLEKSLQECPAQTERDQNALIYSLKMLTDDPELLPFIEGIPTVLGFSSTHEQLGTYTISFHHQNVALLLPLLGSFDLEENILFRISQFAARLSDRRDDHFCQRGSSACSQALWSLALMLLVTSHQQRLQIDQDDIQVYCSSLITLYKYYRHTLSAHPSALAAMRLSWLFGICSLVDWVEKILIKPLSNTSTHMVGTAVPAVVDVQLKRCFMFAESLVQRTWPGPNPNLRHFVHSSWDLRGISSAGHPLSYHKLMKVLRDGALSARSTEHLDHTRNIIADLKDKAMWKSMRLDILMQYLLKSGPTVAEGKLPYWFEETCNAIYNFGEAVMDSDELGLVADHYTDPLLSLPVHLDKNSDAFSHNTDIFIKQCMKLFFSVTGALWNTPMAAESRRFVTWYFHNRIPSTDAPSYSKFFEWPNYMIDRMGDCIVKGLRDDGNESTLYLMAAWKWTVMCSKSRLNRVSLSDLWVVFEAASPVLRQDELYPVVRNVAHQAVLDDIIYRGLGSQSPDLSVLECALLREYLPDEPPASLETTNVISSRGSLKIAITSQRVALSSRHNICSAAESWVDSLVIPEVGLGEAVDETRQEAFAHSVANLVGAVMSTKDIEPDHSFYRALDVVWTFSCCYDDDDWVTQQWYWVTSPKGAKILLQAIEEYEASQAFRNIQLNEDVLHPRGRQRLRDRCRIVLEASVSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMR5</accession>
    <name>A0A8H5LMR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMR5"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5362873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="421" mass="47359" checksum="F1E933607F6F096F" modified="2022-01-19" version="1">MSSTEVPFKISVSDDQLDLLRKKLDLVTFPDELENAGWRYGAPLSDIKRLVARWKDGYEWRAEEAKLNEELPQFTRDIEVKGHGTLNIHYVHKKSEVENAIPLLFVHGWPGSFIEVRKILPLLVQASPNGKFPSFHVVAFSLPGYGFSEAPRKPGFAIEQHAEVGHKLMLALGYNEYVTQGGDWGSAITRKIALKYGGKYSKAWHTNMASGVRPTFTSHPISYLQYLVRPFTAEDKAGYERTMWFQQEGRGYFMEQSTQPQTLGYSLADSPVGLLAWIYEKLVNWTDGYPWTDDEVLTWISIYQFSRAGPAANTRIYFEYMHSKDAAPGALAAGMPTIPMGVSRFPKELAVLPKSWMSHTYNNIVFVGEHASGGHFAAHEKPELLVGDLRKMFGKKGPVYGVVTGKTGYVRSKRGAERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LP59</accession>
    <name>A0A8H5LP59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LP59"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="158" mass="17992" checksum="B8969FBAEB0C4419" modified="2022-01-19" version="1">MNDTYPASPHPYRTLHLTSTHSFKAMPNDTQAPAPSHLSIRARIKFIILRLWLFRNPRRKTGSTAQQEVYTSGSSSDNVEGDKHMKGDEPDPDLENGALVTVAPTFIPIPILNLHVRKPPQRQFQQEGFIQHIPNGCLPLAQHYFSHLYHDDDKPQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPI0</accession>
    <name>A0A8H5LPI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_009311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPI0"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5364807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59048" checksum="78CDB9A19DBC20AA" modified="2022-01-19" version="1">MSDSEKHVNEQHSQEGSSMEEIDLVTFHEKRAGRLVVDPEEAKIEFGEAFTSRLKLSRDGTKILWPQPTDSPHDPMNWSDRKKALHLMIITLAAIVPDFDSGIGIAAIFALANQFNVDTGVINNMTSNWSIFLLGWGGIPAIWLIRRYGRLPILFWSQVLALGFLVGCTFAPNLKTFTAMRCLTAFFATAPQITGLYVVTDLFPFHLQARKLNIWTMGFIISPFLSPFAFGFLVARTTWRWAYGIGSIYGAIVCILIVLFMEETMYDRHVKPIPEPMAKGGWRYRIETLVGITGAKMAKYRMSWFETLSSPFRVVWRPHLLGILFFEALLFGFSIGINVTNAVFLGSPPPRGFGWSEFAVAGGYGTPIVAVLVGELIGRFNNDFIQNWSIRRNRGVFYAESRLWACYLAIVLYICGFLLLGGALQNNLSPGALIMGWGIAETAVMINTVAVYAYCNDCFPKHQGEISALINLARTLGGFSVAYFQVPWAEKHGALQTFGCEAAIVVGLFILIVPWLQLKGAALRERFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPM7</accession>
    <name>A0A8H5LPM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPM7"/>
    <dbReference type="OrthoDB" id="3115065at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="898" mass="100657" checksum="99228A36FB4BD321" modified="2022-01-19" version="1">MYGLASSYTSFRVSLGPTPCNSSTNNLAAFDSHTQQPHQSASHIAGCQNCSLYRCLEDDRKFLSSMEKRRPDYGRRFEWLWYCVCWVAPRDSSAGRIRMWRSLVDSEDIWSMWDEGDESQLPPPSSSLLRRECDPIIGIISRRLDLHSRSHCVGKALLSTTDDITVFEMVFEMRYAIILWKSILACRSSKYRLNPSSIDHDLPHLVLRWWDMIAYPFGGSQLGAIAAYQPFWATFCATLSQRGHTCCQGHPQELMWKVWVIIQTGLRAPIPLSLPGHPDCQQCVKLRGSSLERLGSVRAHVLALWCLTKEVGTSDAPCAPTYWKPNLITPSFGRPVHVDLADNILNQVNLCQVDEWLHKLSCDSGYKSLPLFRGLRVPDPRWIPSSWLTQLYKNENDLDLHWSETEVAISDVISSKSPDLLFVPASWICAVVLFAIVNSVGFGAAAAQRFQHFVCGQQTGIHKLLDAAPVIIESEAVRNFRIALENCGHTCWGDKSCGPHSVSDLYSSAYSMLVNTSDVAVVGCEEESQSSDCDACRIKQAVRTLFDAFGEDGLAASMPSSSSRYNAAKRLISKINSHRDQRDRQLLNYDNVKELSESLGRISTTLHQVLDDNAREESSFFSNIDTGQDSQRTEEDGGEEQGHSSSQNTTTHEVVAQVSPVDMPVHECTERLQSHPRSPTAECTAYHSSSIASIDSLVSLDERQGCTLETDHVRFSNITLSTLVEGNRYRPEQFQSLAVSVAQDTFRQETGLSRSSRALRQSKKPRIDRMRFEIKDKFLSILKSHNIDSGNKLPWRSLPNVLRERGYKLQNWPDGIPLPDTQNGIEKAPASQIIAIYDALNNGQRPLGICRIDGSLGRPGETSFIMEDPSSVCGAKRSRSERDEGEDADVLNVRRRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQE9</accession>
    <name>A0A8H5LQE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQE9"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="195"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5365571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="960" mass="105360" checksum="F90D276ECDFDCE9F" modified="2022-01-19" version="1">MKAFFSRLHLGSTREKEKLQSSPSEPSLKPLPQINEDHLIPESPTPTPTPPPPDPDSAVHKKVAFISPPLTPVQPVVVVPPDPAPVSPTAPPLKTSVSRFQDTHAGRGSTSSAGASSSKTNLASSSKASVKATSTRTASPYLHKQDAVSAQSLRSGTPYSQMSNNTSGSRILAATSWSQVTEEDLVTNLGSRERTRQEVLFEIISSEERYVSELAKMKDTFIDPLLHPYSSTPVSPLSSTPNLDYEYYRTESPVESTDQLPPIAARFMSPTPSLRPPESSSRQKDHIDAESMDTDEEEDNYQPPAKRFGSPKPPAKNTSQAAKHNHPRSPYRSTVTKNVGKNGTTVPFPSRSHHSLPPPPRSQQLSASTHSLGRQSVIIERERERNYSQGQSSLADRKGDSRPGMLRKFNRKNDNKGVLGDSVAPHQLPEDLRICLEVIDSGVFDGHKRLSEALRKRYEDQFPLVRSLADVFVSNSDIFQGYAKYVLHLERALEQVDNALSNASTKKPKNQDVAEWQKVCRVIKRLEESASEKGETGLAISLSKPFQRLLKYPLLFQNLLFHTDPSTFEYESTLQMVAEVETIVRSIEDEKIQKEERDKTRDVFARIEGIDKVRQVAAPKPSRVLVEERQYNAGPSSPSSGLSKPASPPPVATNGKGVKGKSSFRRLSDVLNTGKKDLWLVVFNDVVLLCQKTGTTSLPLVAATNSRTNSLPELQGRSKYASTGRRNSQTKPRNLYKFIKIETWAIGDVVQPREGVVSMEDVARSRAQMNTQPRIVPLPPDDEDEDGGADSDDSDRKSKMSFSYWGADKITVQKPVVKPRAGLTVRRGGHGPAYARESSANAKFGTRLVSNESSSSPRPASRRTTNTPTVRRNGYSEDGHNSAKATVTKPGWNTSTRTPTATPVSKRSRNISQTSATARTTGASAVPAKVLASPAPSEDSGVGLYRQMMANDPNLNQLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQP0</accession>
    <name>A0A8H5LQP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQP0"/>
    <dbReference type="OrthoDB" id="2631350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61635" checksum="8E8ED08F835D7615" modified="2022-01-19" version="1">MMRSLSKMPSSTALPTELIEEIVSYMVDVQNDSWFQIEVLTVASKRDLLSCALSCTAFFGPAMRTLWSTAELTRLLQLLPGLDWQLLPGLVVGSSCVLTDELTEVSLKRFDIYTSMVKTLVHHGDWRDYTSVCSSLALIRPRPLLSLKHVYFHTYRLTFSWSGEMMLMVSPVLKSAFFSFCSPSIMAYISIIKDEATMSDSLTISLTIPHARYANFDLACISQLQNLRFLHLFLDLSTVETGASAVSHPRHLKELRLDYDKALNTPKDVFTVLRIYRNSGVESFSLQGALQGVDIQRILNAMSSQWSRTLTTLSLNISINQWPIGKETFLDIIRPLRSLHKLQVFMGKFTLGPTGPTDWISAPPVIYITHPLIPDICNAWHNLVDLEIRTDGFENILAVASLAEHCPKLKRLSIPFDILAVPSIDDVQHRNTFPLESSHKLESITLMVKEGTDLEGTDFVSLVARGSVISRLAYLLDLTFPYLKEVSIRTTSAFRLPPNALPLAAPLATAHRPPPRPVPARAGWKNSRNVIMDVIRARQEARRLKGTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRV3</accession>
    <name>A0A8H5LRV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRV3"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="326" mass="37436" checksum="85C34D240931714D" modified="2022-01-19" version="1">MSMTRPRVFFDFAVDNQPLGRVIFELYSDTAPKTCENFRALCTGEKGLTPSGIPLYYKNSIIHRSIKDFMIQGGDFTKRNGTGGESIYGGMFPDEDLSRPLDSEALLCMANRGPDTNGSQFFITLRPCPHLNGKHVIFGRVLRGFEEVVQKIVDVPVDGKDKPISTVAISNCGELELRKKQPPPPPVERQSRSASVSDSEEASRHKPSRRRKSRRSRSPSSQSAENSDQSEQRHRRKKHKRSKRERKENDVKKDQSKPVVNERGETEEEYDARLEREEKERIEAARKRELERVKSQYEQETQSSSGVRFKGRGRMKYIDPDVNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LS95</accession>
    <name>A0A8H5LS95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LS95"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131035" checksum="3D87301D176EBA71" modified="2022-01-19" version="1">MLRFFLGKSHPDRVKSLVLSEVRFFFQDGASHLFPEAWDEFIAPIPEPERHDMILAYHAQLNSADEGTRINAAKAWSKWEMATSKLFVDPAYVAKAEDDQFANAVARMENHYFVNDGFMRDGQLLEEQEIDKIRHIPCIVVQGRYDINCPVTTAYALKKVWPEITLHIVPDAGHSSREPGNAKLLVETLNEHNKKVGVIVVTDWIWCIVQYLEKNKKVQGVVHFGKQCLGSRIVHERQTGTPLGQGRRLDHHTFLGKPPSNGNRPPSPHRIPPSSYAYGAPALGSRSPPKASTSLPLDRNNTSLDQSTEDPALVRFPKPKQQSHLPGAPKIITSPPQNEKWSVKDTSVLAASALYQAAFGIESMQSTNPNHSWASGSRTTTNMPRSTSVEYEQQSVSTSTRRLAPPPSRNASLASKSNTHSRPKPLSKKSTSSLRIVPDSEGEESQSMNRSARGTSPLDTVMDLANKAYQKASFYVRERSREPENVNGNGSYDYAAEESAYQNEIADDASKRGLAQHRKNRMSMDNKAYKPTQDSEDDEDYDDEVPSDGKRRRKKKKKEAPGGPLQSLPVVGAEKRRKKKKGTKGAADEEEAEGEEASGSEVVERQSAQRASLRRSASRHPSVQPQNVEDSFDVEQGLQSIPEDDVLSSAEDTYNDSTGNISSSSLNNDGIGAKLGTLVFMLFRLGMATITMIFHSFGKMMGMIFDIIILRPVRMVTDMRDRPLSPGFKYLLAAVAIALAAYSFQGSLKGLHLPTWSSSPSYSAPQAPIENLAELNARLQSIETTLSNLARENEQTRIRNENGEKTRMELAGRLGSLEGVVNKDSGKLRDIELSVGDADKERRALGAVQKEVLVLKEIVDILQQRPPSSGEGSERVSSDAEARAKLQALEERVGTVEGGVKEALELGKNAVKTGSGTGWWNKGSTKGLTIKSSDGQDVTTLIQNLVDSAVSLYGKDILARPDFAQYSGGARIIPALTSRTFELRPPNSQGLWGSIVGGGPHIGKPPVFALHRDLQNGECWPMAGTKGRLGVALASPAYIDSITIDHVPSETSFDMRSAPRHMEVWGLVDGAANFAKYKQWMQDKEQEHEEARQRGEEVPAEPEYPSDLPKNYIRVASFAYNIHASPNVQTFPVLSDVKELGIDFGIVVLRILDNWGRDEFTCLYRFRVHGQQMAELPSPLPEESLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSK0</accession>
    <name>A0A8H5LSK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSK0"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46285" checksum="61F71F118DFF189F" modified="2022-01-19" version="1">MALYSSPSPKSYAGKNDARSNISAGEAYLQPNRRNQVQVSYRDREQLVGGSHELPALHTDSDFIIMPIEDPPVSKSKSNPILRSEATGFGEKQNGLFWPFLTFYRAVSGMLGFKERYSLFFAFVCGGGLFGFCLARAFMMDGKTRRQQSPPGDYRWFDERLYGISYAFHVYTCIVGGIFVGLQFLPAIRRNFVLFHRLNGYFCIVLLIPGNIAGAIVARRSYGGEINQQAVWYLLTVMFTFSILMGLFNVKRNTQAHRKWMLRAVVYFAVVILAKVLSIISRAIITNIGGYYSVWRCDEVNYVLQNADALFQRFPQCNNTAVDISNNPFSVAVLASDSEGKLEHSSALRLVAGMCLWLSLMIHLVGVEIYLYRTEDQNSMRRGYVLESREGPEGDYGDGADAADRDMAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSK3</accession>
    <name>A0A8H5LSK3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_002310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSK3"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5368465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="338" mass="37848" checksum="1190CF6D737A778C" modified="2022-01-19" version="1">MPIQDRTNEFKACVDSITSRSSFPNRRGEHKQKLLNGKAGSSKSEFSRMATAIGKDISSTNLKLNKLTQLAKRKTLFDDRPVEISELTFIIKQDIANLNKQIASLRSYVKQQNHKGSTSAEGKQLEEHTQNVVMLLQSKLASTSMTFKDVLELRTQNMKESKDRTEQFMSTTSSAVQQPPSNSILFNPRGDPMGDGSPSRFDSKGKRPAYENGDVLALNLESAEEGAQQHQNGNGFMQMQLMEQQDTYLQSRSTAIESIESTIAELGQIFTQLANMVAEQRETVQRIDADVMDIQSNVGGAQRELLKYYASISSNRWLMLKIFGVLIVFFLIFILVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSK8</accession>
    <name>A0A8H5LSK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_002233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSK8"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034933406" evidence="1">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5368480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="535" mass="60564" checksum="38E73089B7C301A4" modified="2022-01-19" version="1">MLGFLRGLLFIAFQSIGSFQGLTGSMRLPNPITHLERKLGDTEASYFLPSRENGVNDMYLHLGFRAPLYIMDPQCVALVWSILRIRHPLLASQVEMHSYDDIRFVYTPPRSPEEALKLAESNIDYRTQPKDELLDSYLNGQRTLSSSRLSYLIVSNPEKAGVTMNGDSSTLLGSSNTDVSREYDLMICATHFLGDGMALHAFANEFFSLLSSSDSKGLQDLLTFEWQERCFKRTPASFLPTAMEDRLPECSTTLQRVASRVEFRNSQDRLIGGQTFPKGARKARETVAPTVSFDEERTKKILKACKNHGVSISSALFAICNIAWAKTSKVKWDLPTMMYSALNMRPYLSPSRQLSDSYWFLSIGYFNVILPTFIPKDDDDLTRTFWHRARSAKEQSTNAVKHPMLIPRTREMARERGARARVWAKEDDDKALGIWKPAPATTQNKPSPRAPSSALIGLSLLGNLDGTYKHSRYPEIELHTLTTGSRQRPGGMLLFGYTFRSKFWVSLGYDKNGFEEGVVERFWNQVLLSIEELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSM5</accession>
    <name>A0A8H5LSM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSM5"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="279"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="912"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5368077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1276" mass="137246" checksum="113979B7D5866CFE" modified="2022-01-19" version="1">MTSNTSSGSIKSIDAASVHRITSGQVVIDLQTAVKELVENSLDAGATSIEVRFKNYGLNSIEVIDNGGGIAESDHDSIGMYNRDMRVCRSLLIASIGRKHHTSKLSSFNDLTLISSFGFRGEALSSLCALCESVTVTTATVEKAPMGTVLELAKSGEVAKRSKAVRQRGTSILLKSPFAPLPVRRKELERNVKREYGKALALLNAYALGPCCGLGSFSETNTSNHSANDVNSTADASESENKLKAVRLIVTNQPDKGQKATHISIPLPRTGSPSVKIGITALWGPKALDGVIDLNLQFEVPKVLPKTFGRKQTSSDDNEGKSLTVRVQGLISSPIPVPGSGSSSRSGAGRSGTDRQFFYINGRPCGLTKIQKVFNETYRSFSPSAVVAAQFPFIVANFTVDGDTVDINVTPDKRTVLLHAESHIIDALKTALEELFQPSRSTFGVNGHTGAQAQGQTQIQSVSVGQARSTSMRPPATTSSLSTSSQAGLNRSASVGSRRRGSMVASRSVEVDDGDDGGEEEEEEEVEGDLPSRVGRDTQRMANTSINANSENDDTDDDDDHQRSHNGTAQTPSASSEPISSASAVIKENTTSLIPPSATPPLAKALVAALDANRREEERERVKDKDKSSVVLKTTNASWNYVQTSSSSAPMSASASAPSPPPAIAIHIPETQDTDTDEDDEPPRKRRRSSAVPNGLDMVARATASGDDSGDEEIDEAQVQGHTVSSSATQGQGEGKAPSSFKARVGKAAASLAGGGGSGGGGSGSGLRQTKLTDSGSFKGGSGSAAARRDMRSKLVGFARVGSQIQQPSSDAEDEQGEEQGEEDQIVEDEDEGKGPRQNDNDSTMDVDAPLFLPGEDDDEDATVPDDMDVDHDATSSSVVSFNTSSVNGPPSSTLATSTLLSSSSEIINLLDDDDDESGAASSSLLSASERDQQLSESRESQPVDRPEVIRTASSQTSDGDVHLRFNLSAIMRRWSLLREKHQAAREKSAKAKDGILGRNRQIADDNDENTDFSDDLQEAEAKLSRVIDKKDFEKMDVIGQFNLGFVIVRRRKRGLQRGDSTVEDQVLSKEDAASLDDLFIVDQHAADEKYNFETLQQTTVIQSQRLFRPQALELTASDELVAIENLDVLRSNGFELEVRKDPDIEMLDNEMSGTQMRSRLSLVAQPVSKSTVFDMKDLEELIHLLQDRPTGQMVRCSKARAMFASRACRKSVMVGMPLTRGQMTTVVHHMGTMDQPWNCPHGRPTMRHLFDMSNMNSDSKPSPRVRKKVDWSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSP7</accession>
    <name>A0A8H5LSP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSP7"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="698" mass="80732" checksum="B44F268A5DFDE29A" modified="2022-01-19" version="1">MSSSTTRRRSSRLAELAVQATANTSASSDTVDDQPKRKRARISLDYDSEDEDEDEEKVPKLRGNRGKLEKLTEIPLDILFEIFGYLTPYDVLRLARTTKGLRTLLMSKSSSSVWQAARSNVPALPSPLAGMSEPEYANLTFDARCHSCNSLRCENIIWRFSTRLCNRCLPLLFTPTENLTAPDFMPMLWQYKKMHGYLLLDCVPHISITPGKEPFRTASKNLSLERAYLQPLVDRLLNEYRNTKDDSSALAAWIKLKDTKAYEQWHSARLANRSEELEKTRVRRREAWVSYNLDFSLPHSPSSSYSILQRLSKQGWEKEVKFVKEHRSWDFNKHALVYQTKDLTDRIWKNIEEPMTQFMEQIRIIRIRKECRPRYTILRKVYPEYVDLQPPDLLVPIIGDVLPLNLVKEIAEQPCSEEDPLDEDIFQPLLDLLPEISRAWASEVEEELVKIAKATKPDFQPSSLKLATTVFQCNSLYCKERMSYDMILKHSCATSARFTAQGERRPEQFSGQIEDADFFGAMPWNEGGDRVNFDLVGSAKAKVIVEKLGLDPAITTGENLDRGDYAFECTRCKRKRDGRECRYLMRWQKALNHSCKTQFLVKNPREGPEHEAFLRAETEAVFDGDRRHSWGWGARPVQKALACKHEGCSQRFSYDGFKQHLFDVHQKRKVESSDWTWSACATFSEVYKDLWVPVRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSV8</accession>
    <name>A0A8H5LSV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSV8"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="4">
        <location>
            <begin position="222"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5368332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40513" checksum="88B3FAAAA669F519" modified="2022-01-19" version="1">MDHLQTNLPYSRPNTPGLHPSQIGFVGIGAMGYFMARNLANRRVIPGFAHAPLLLWNRSAEKPQKLVKELGEERVRITQSIEEIVNSCEVIITNLANDEVVKSIYDQFLKILTQSPPVKNKIFVETSTVGLILSVLYILTGLSSISGNLITLGELDGLLSQIRHVHFVTAPVFGTPSVADKAQLVIIMSGDYRSKKELAYLLVPSMGRKVIDVGENVEKAPTFKLIGNSMILGAIEVFGEAYTLGEKAGIEADRVNELVKDIFPAPGLMAYSDRMANDNFDGSIGFAIDGGIKDATHIRRLTATYNSPMPAIDVAHQHLITARAIHTTQKLEGKQSVETLDWSGIIAGSRVAAGLDPFDSKKHQSIVQEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUL0</accession>
    <name>A0A8H5LUL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_001142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUL0"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5369999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18283" checksum="EED02047FEDA5CE0" modified="2022-01-19" version="1">MTVDNRFKPFSLLKRYTTFLFIRYQGLHPIGKVAIWLVVLFYVLAGAFIIIITPARIFQALYDFADKLASLRFGWLILATALVAVSFPPLIGHTTLVTLCGFAYGMKGFAIASTASIFGSALVFVMLRFLFTRRLRHWSSQNEKWQALEAVVASRPICDILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUL7</accession>
    <name>A0A8H5LUL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_002057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUL7"/>
    <dbReference type="OrthoDB" id="3022198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21712" checksum="B4DC4F3EF799DFC7" modified="2022-01-19" version="1">MDASRMVCSEKLFSFVMPQTLSVDLHKRIVHWRINEQREVSEIAELAGCAERTVYSILKLYADMGTYQSKVTGVGRPRLFTMEDKAYTVSVFRQNPTLYLNKLQDRMWRDRELDVSIATISRTLREMAMSNKKVAYEALQRDERLQNIWIGENGGIPMEYIVCLDEAGIRGDDHHRLQGWESLGMACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LV68</accession>
    <name>A0A8H5LV68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TFIID-18kDa-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LV68"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5371210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39929" checksum="FAC7BF2DFF74F513" modified="2022-01-19" version="1">MATKKIGDIMGSVTKDYKYTQEISQMMFVFGEVQDPNPETVNLVEDIVRSQLIELIVQARALAVRRGVRYLSAEDLIFLIRHDRGKVNRLRTYLSWKDVRKHAKDSGGDGGGGMEEALEDGDDKLAAKAQKITIKLPWEITTIYSEVLRQSGHQSDDEEDEDDIEAHEASIQRLKEADDATRQMTREEYQHYSDCRQASFTYRKAKRFREFLNLPSHLDLRQNDDTVDIVGFLAFEMVRSLTIAGLTVKKSLEEAILREEYASPVMGKRKANNMGGSAEKRRREESPDREEFTLPVNSLFLPPPEARTALRPEHIQDAFSRMQGDWAHSRSAGMHNWRGGLVRTRISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVB1</accession>
    <name>A0A8H5LVB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_001799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVB1"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="758"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5370853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1033" mass="117223" checksum="4AE02E8EB44D646E" modified="2022-01-19" version="1">MNTFPSNLPYWSNLEVLHENTLPPRAYFFPFSSEADALSYDPSRSSSVCLSGTWKFHLANSPLGAPEFSDTSNWTDIQVPGMWQLQGFGKGPHYTNTPYPFPVDPPNVPFDANETGSYVRTFTIPSSFKETQVRLRFEGVDSSFHVWINGTKVGYSQGSRNASEFDVSTLLQYDKENTIVVRVYQFCDGSYIEDQDQWWLSGIFRDVFLLSFPRNRIEDLHVQTLLDEHYHDATLSVKIDTAGESLPATVKLFDESNSLILESIETFSSDSSKHLTFSISNPHKWTAETPYLYHLVLSIPGQIIAVRVGFRSVAVRDGVFLVNGQAVKLRGVNRHEHHPKYGRAVPYEFMKADLHLMKKHNINAIRTCHQPSDPRMYDLADRLGFWIIDEADLECHGFADVEEAIMGSELDHLRGKERQNYVYDLAARWTTDNPEWEKAYVDRASRLVSRDKNHPCVVMWSMGNEAFFGRNFEAMSAWIKEHDPTRPVHYEADREAKTTDVMSQMYSSVDTIMKYAEDPASEKPLVLCEYIHSMGNGPGAIKEYIEAFYKYPRLMGGYLWEWANHGLLTKNEEGKEYYGYGGDFGDEPNDGNFVMDGALFSDHSPTPGLLEYKKAIEPVQVLDGNEKKIEIINRYDFLSLDHLKCEWHIVGDDFTMVGGEIPIPTNIQPGQSVSLVIPAPASHSLPGEAYLSVVFTLRDATLWASAGHEVAKSQILIKPIVPSLSGTSYIRSSYNKLMSLVPQSRSSFTVNEDNKALIIRSKHSQWTFDMTRGLLVSWKKNEKEHLSSPPVMDFYRALTDNDRPQDGANWIDKRLHQANSHFRSISWEAASDGSFKVTVTARIAPPVLEWSVDTLTTYTFSDGGLKIRVDGKPQGANLPKTFARIGLTFLLPEVFKQVKWFGRGPGESYKDKKFSQMFGTWSASVDELFTNYEYPQEGSNRTDVRWVTFSSVDTSLRAFFPSQEGGNFCATHYTTKALDAAKHPFELEKFRLKDIVVRLDSDHHGLGTGSCGPKTLEKYALKAENFKYEVWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW92</accession>
    <name>A0A8H5LW92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW92"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034308101" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="52467" checksum="AD5C0EE26663A826" modified="2022-01-19" version="1">MAKLFFGSLLALSTLAVSLVEGNLVYPAYGGVPIADAGSVDFNNSLTDTDSIVSTAQIVDQKGGAAGDVIPPPPPPVMLTAIDGDLVNVTVDSLVADQTQSSPTKRSVKDYVQIFKGTGTGPNDRDGSIEGTGYLTFTVVDNSTYNVDACLNFCDRVEQCVFANLYYEFNNPGLDSGGSNLKCAVYADVHKASEKLNRGGQQLAPPPAGLTYIQQSTGWTTKSLPEPKTPDGFELVFGPTNGANNAPGYMGFAFIDRYDVQACADLCNTRGADSQGGNCQYFNIWRALVDGVPTTYTCSMYFLVADESTAVNFGQGDLAVSESRGYRRKNVIPDGGFEGFNCGTNITAPFCFTPGYSAWKGISPATGHLDASIFNYAPYARTGHGVALLGSAFGEDDFPGTLTPASSLDTEAGKTYTLQFFHSSAFSGPEGEADAFVEVHWNDAVIATIKPGFSSWTFYSFNVVAQGNDVLQFHGGKAPSYDFLDDVSLFLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY46</accession>
    <name>A0A8H5LY46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY46"/>
    <dbReference type="OrthoDB" id="3264363at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="353" mass="39533" checksum="CEF7F66979ACF620" modified="2022-01-19" version="1">MSSGRVNDLLHRARGEQYRHSQNLRRSRTHIAVPSRNLPSLPFNLIDLDPPTTENSLIESTKEKPDQRALKKYSGPDPPKSWTLTAAKDVRNTAAWRKQALAAVFAHRSQFRHETHLTTAELIDEANPKLPSLVTLCLEMLVNEFTTSEFIEDIVPCLPPHLRLQLLRYTAVHSPLSGVMLQSLLIPDGHTDGELIVVGPSASLRGTFFLSSSSDMTDAASSSPQAARNISQDWDDDDGTPNPLQCFIYMSTRLSPSLLLSLPPSITHLALINLPTSIALHRLPGVCPLIKFLDLSYNTWLNPMSTDAANSLSRLDWDRWSHLRTLCLRESSIPEDMLVKVNKNRWDEVGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AUZ3</accession>
    <name>A0A8H5AUZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_019066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000569">
        <property type="protein sequence ID" value="KAF5311251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AUZ3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5311251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="20827" checksum="A7199062C7EB7256" modified="2022-01-19" version="1">MNMKGCSGGSNTGSRRRKDHDEDVDIDMMPIMGVLAKWGGIVRRIWEGRGSCQEELMEEVLYSENNSSIEQSDCGDDTNQRLPADYILQATAHLPVVSNSSAPSPVQPDALVPASEMPAVTASSQVSYIGTGEIILAALFFVIFVLLVNLLFMYLEESAVEAESESEPEGGARAIYWREEKEALLSNYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B890</accession>
    <name>A0A8H5B890_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000479">
        <property type="protein sequence ID" value="KAF5317467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B890"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="146" mass="16531" checksum="10F2598C5648752E" modified="2022-01-19" version="1">MGVSFLCCPIGGLQILSPDGKWRWIKHIDNALVINAGDAMEFLCGGFYPPTRHRVIQPPSDQRHLSRLGTFYFAMADDDVKLVPHEESPVLQRVGIKRLCSNDEAPTMEHWRKGRTTAYGNSVLRPGKEINVEEENIHGVLVKHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BGX7</accession>
    <name>A0A8H5BGX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hepcidin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000398">
        <property type="protein sequence ID" value="KAF5323164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BGX7"/>
    <dbReference type="OrthoDB" id="3025387at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034126186" description="Hepcidin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5323164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8209" checksum="E30DEA2B341BD900" modified="2022-01-19" version="1">MKFSITTTLLFALFAPASGAVIQKRDDVATVASPITEPTVVTATRVFPTLIDEPPFMKTVTSEVVWTQYPVTYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVM2</accession>
    <name>A0A8H5BVM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_014442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000331">
        <property type="protein sequence ID" value="KAF5330255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVM2"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040909">
        <property type="entry name" value="CHFR_Znf-CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17979">
        <property type="entry name" value="zf-CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5330255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="475" mass="52035" checksum="79245F924354FD36" modified="2022-01-19" version="1">MVEESSASSQNFNATLEALSARPEPPGTTTLKRPASPTFDNSNDETSRKRMRGEEGCRNENQLSQEMVIASGDSALANDLAQELQCGCCSELVHKPVVVSPCQHFFCGSCCALWIRNGGTSCPACRGESTIVTPSRPLQIVLDTLLKSAPHKARAEGERRQADEIYKGGAVLRFPSPREVSPEPNMNLSAEFARPCPHCLPNNPYGWRCPQPIPDPNTDVENAWRMDDGLPAGHGNCGHCENFLALQAPTTTKCDFCQVSFCGVAVPGRCVAAPLLVQHPHEMSDIADLIQSTEVYECFNQNEIEVEYIIDYLTANNVTPRHIYREIVVHVQGQPQQFRPLLELDLFSDMHPVSGGTDPDPSVPRQKICRHCATEVLLWGLKEWWVRERLKGHLEEHILARKDCPEGNSCSRQKDLAHAREFNHIISTVSAPEALEAPAIPSEAEAPSAAAGVEPENGPVVGNAAEQLALESTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZF3</accession>
    <name>A0A8H5BZF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_014588</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000316">
        <property type="protein sequence ID" value="KAF5332034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000016">
        <property type="entry name" value="Putative Lysine-specific demethylase 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="16">
        <location>
            <begin position="225"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="427"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="580"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="319"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1597"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1740"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1612"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1650"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1701"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1719"/>
            <end position="1728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5332034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1840" mass="207955" checksum="D909608AE4A5D8F4" modified="2022-01-19" version="1">MHGSPKSTTPRGTPSRRGKSPRFHSPNATQSSAPSHSEVANNPSESFFSCLSIPVEGSTPIGDDNAKVPQPPPEQATTSEPKRAPRKSKTDALAALNNQAMSSSDEADDYFSLNNLTERYRNAKPIPVDPILDLSTVRTSAPRHFSHLKSSPRPFGLEDCPEFYPTEEEFRDPMAYITSISEKAKQYGICKIVPPEGWRMPFTTDTERFRFKTRLQRLNNIEASSRAKLNFLEQLYRYHKQQGNPRIVVPTINHKSLDLWLLRKEVHKLGGLSAVNKDRKWIDVGRALGYIGLPTLPAQLRSAYTRIILPYEDFCERGRNTPLSPPRSSHNKPQVNGTPGNPTNNTGDVSAPSSPLTTSSSPLSEPPDESESKDQVANAKPRRSTRRMSQVETPKKSTVEPTPLATPVFRDSKPEPEIRVKDRSSDDAPCEICGKLDKGTEMLLCDGCDLGFHMFCLDPPLTSVPADEWYCHPCLTSTGGDFGFDEGEEHSLSSFQARDKEFRQTWFRSHPPPSGKGKKTDDPTASHFGDVTVNEHDVENEFWRLVQSADETVEIEYGADIHSTTHGSAMPTMETYPLDPYSKDPWNLNNIPVLPDSLLRFIKSDISGMTVPWTYVGMTFSTFCWHNEDHYTYSVNFMHWGETKTWYGIPGEDAEKFEAAIQFEAPDLFELQPDLLFQLVTLMNPKRLVDAGVRVYACNQRAGEFVLTFPKAYHAGFNQGLNFNEAVNFALPDWLPLGRDCVQRYRAFRKLPVFSHDELLITITEHSSSIKTALWLTESLNEMTQREMTVRRRARQMDMKESLDRNTGPQAEEQYQCAICKVFCYLSQITCGHHRDKVVCVEHAHLLCDKCDPGSEMTLRKRFSDDELLEIQVRFTDRAAVPSIWQAKLRKLLTESPRPPLRSLKALLAEGDRIHLNYNLPDIYTLRKCVMRASEWVEAASSFTLRKQGRKRPRRSRGRLAQNDMDDAERPEKTVDDLYTLLQEVEQLGFDCPEISALRNLGQQAEELKVRANALLQVPSAEWENDDFRQKCQSLVLDASSLNVLIDAVVEVEKIVDREQLVKELEEKLGESKQPLNLDEVRQYLNRAHQCNFSSEHPFVQDLDARLRAGSGWEERAKTLLAKPVKTIEELEEFANLDNSIPLEPAVVDRILAALAKAKEYERIATSWLCPDSGTAKPRPMDVMKLTKRASEFSLTRLQEAQGRAKIAQELEEQSEQVLKGSYTPSANEDLFKSIQEWKVYATEHLLGIFSLPSFEKLDAQVRAHEQWLTSLPWWSQKDQTAHSEPVLKDVMESTHSDDDTPPNDEYFTCICFQPVRPPPPGTQSDAVQCDHCFARFHGECAKNGGSCPFCDHHHWNGEIHKERSYHFCYLPGILLNAPDITKRFSEEWSRLEKIVTKVDRLSTVIGQFLAFTSQPANQHPTYIHQVRHYMRKLYKIQFAVSPNPEVSYGLDLAGLHRILAGRPKKKRKPKLVFGQDIDQDWNDKTRCICRGRTAYLLHYPTIPCSQCERLYHAGCVFFPLDKNARFTCPLCCLRKNKPYPWSEVRVLPPAEENQPQNTYIDVKTMLEQGSQEVIYVNLPSPYQHTLFVELVKYSPGQPEHGPQYSPYTQRSPPPIMYQAPVPPAAPMIPSPPSNSQVPPPPWSRWAPMTTPSQPPSTQRRQTVEAHSSRKRKHEDNEDNYPPMASLPIDQSSKRRAVLPAPVPPPESAPSTPLPPPVQTQTPTQTLSPSLAKLMSPVDQVSPRPIYNAPPHPHPHPHSSARSNGHESHHGSPLMRNGGVDILSSPPMRGLGDSPRLPPIIRPEVARNGNAGSPPPIRTGNGIDPHTSPPIRKMMMSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C773</accession>
    <name>A0A8H5C773_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_017379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000245">
        <property type="protein sequence ID" value="KAF5335257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C773"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="177"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="677"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="720"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="763"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="806"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="849"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="892"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="935"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5335257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116964" checksum="DBD14C6254C4BB07" modified="2022-01-19" version="1">MGKKRFGLGKGKTPGKERKETEAEQQPQAGDTETVGSREISIFKSIERFMSRSGRNSPAISPSTVPSEKHLSTPAEQGVERIVREQPSTKGLATQSSQQIFSNASDFEIRNAEVNNIGGDQINIVNNYAIDEVALTKLKGELQPVLNPVQKTDECLEGTRVQLLKDLCNWVVKPESKLAWVFGIAGTGKSAIAVSLAQRFRAMNDDLKLALTFHCVKGQETSKVSSLVPTICYHLAKQQIETLLDRTLFYSQSNLKVVIIIDGLDEWGSSNEWKILSESLIALSFQFNWFRVVITSRPQTEVDKAINASVAVETFDLMKGYHADKDIHLVLTEGLKKPATWSIVGSHIEKLVEKANGLFIWAKTVQTFITGGMDEIGRLQLILGLPGEDVEEENPYKELYILYAGILQESFQSPKDQSHFRNVMAVLFAVMEPVSPTVLSKLMGSNSPWVVEKILHVMKALVYERDGKLYYHLSFKEFVTSSLDSDGFSCQLPICHQFVLNNCMSILKKELKFNICDLESSDVKNASVKNPPLQDRIQEKVGAHLQYSCMHWATHLDRAGNRAEEILDSVGDFMNGKWLIFWLECMSLLGRMYNLKENLSSIALWAKSIEDTKIEDLAVKAARLMNAFTLPLNESTPHLYVSALSMVSQLNWFDIVRKHLKKGVQIENFDLSSHLLTINAKSEVNSLACSPNGRNVVSGSDDQTVRIWDTENGKQVGEPLQGHTGSVFSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPFQGHTDYVWSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTRSVQSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTRSVWSVAYSPDGKHVVSGSSDQKVRIWDTETGEQVGEPLQGHTDYVRSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTHYVRSVAYSPDGKHVVSGSSDQTVRIWDTETGKQVGEPLQGHTGYVQSVAYSPDGKHVVSGSPERTVRIWNTQVLHDQAFTSYAHSPPMNPATLILRDGCIRYSQIQSSSCGYLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7D5</accession>
    <name>A0A8H5C7D5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000227">
        <property type="protein sequence ID" value="KAF5336630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7D5"/>
    <dbReference type="OrthoDB" id="2919784at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="591" mass="62817" checksum="32125FDCFC942020" modified="2022-01-19" version="1">MTADPTRSFFDHSAISSHADSHKTEPESHVDVVTFKNDGFLSSDLDLTLSFSSPPSPSGLYTPVPSSENALNLNFLPSPSPSSSFFPSGSSPTSSTRELFSSTVNGRPTSSSGPESSSSGLRGSWPISKYVGRGTPIDRSRRNQWGGSQNESGVGEDGVLFSAPGRLRPSMESNSYPAYNRRRDSGSSTESGWHAVPGPRALSPLYLEAESSEHPGSLPVPIVPLPDSSKIQFQVDSDPTEWDSIMKSVLSSGDASAAAAATASSSSHAAALGNSIQRPHTTDPLSSPKGSASRRSSLPVPGIPQHPNGLDIVLGLDNALDLGLNRLGKMNFFDLGLMPSLNGCDGSVSGRDSPSVYSDAQEEIFSAPARTDDTHEFLQRVGGTRGEQGANGNGNNLAGVGAGDGHGHEVYVHKGTEIQEVSKRMSVETIKGTPSDKAQAAVGVGNEDMNGNGSVLQRSFAPNGGPARLHTLHENLDDDDDGSGTVELPSVTSRDHKLSRKSGRERDHWWNRVVTRRKGSDVRFEICMGAREWVGFVIRSLIPILFHFFPSCYTLLPGATSEWTDTSGALMAVLITTLLISWLAKRSGFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7F6</accession>
    <name>A0A8H5C7F6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000226">
        <property type="protein sequence ID" value="KAF5336660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7F6"/>
    <dbReference type="OrthoDB" id="2654453at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5336660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="368" mass="40705" checksum="D8FBDEDA3F593A41" modified="2022-01-19" version="1">MTPFTFTTNSKAPKSKNRKYKLRAFLAGHQGAVACMAAHPLGSHVASGGQEGTLVWKLQDKKLLGSPTGAGDQGVTTALAWMIRPDDTDDGLAFGTERWIFMHLASQPKGTGGGENGQEITAIAFDVNSSQLAVVHRAEIVHRFIVDPLMRLTTIKSTRIKNHWPQAVSFGQTAACGPEIWSFGREDGEIHILDEGGKITMTRTTSVVIETQDICCDDQRTTFKKCWLLISGSDHGDVYVFDRRTSEVNDIIQVGCKDWVQSVTEQTTEMEGVPIIIIGRSGENLGQTALQVWERETPAPEREGACQGRLLQDFYWWQGACEWMEIVTGLDLDRDIDTLPSKKGAHEWMEIVTGLDLRSVADRDIDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAL7</accession>
    <name>A0A8H5CAL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_016037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000209">
        <property type="protein sequence ID" value="KAF5337749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAL7"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10919">
        <property type="entry name" value="CE4_CDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5337749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52037" checksum="86E57C7E93ACBC7E" modified="2022-01-19" version="1">MFFNVGNTCFAGLHGFDIVLIRAKLNSIKDTPQFIVFTADDAVQSYTLDAVNQFLAQRKNPNGCTPRMTYYTSTDYTNYTMVTDWYVAGNEIADHTMTHVGTPPKEEVNGNLIALNALAGIPLSSIKGFRAPFLNYSVDTLKLLAETGFLYDSSASASIPVTDSSSDAYWPYTLDYGMANDCLMVDGMCKGEPKLPGFWEIPMYAFFDSRGVAGPHLMDPWLDAANGASSVNNSATLEYMKNTFTDHYNANRQPIGLYTHPIHLSKNYPGVNADEQMINMINNFLDWAQQQNNVWIVSSEQLLAWVRNPKPISQLDQVPELKCSTPDVPADQKICNGVPQNEEGLLSHCFFDQFPFYTCYGCPESIPNPSSPNPAQKNSDGSTRHRLPENCSTPFWDPVAGSCTCASSSCAFTDTSRPIGPNGANLTGGGTGDSFNGNSSGPSYTPFNGSGAGSIIFGERWAVSVSVVGAVVAAVMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CD07</accession>
    <name>A0A8H5CD07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_008736</name>
        <name evidence="14" type="ORF">D9758_008749</name>
        <name evidence="13" type="ORF">D9758_015319</name>
        <name evidence="12" type="ORF">D9758_015321</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000185">
        <property type="protein sequence ID" value="KAF5339471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000185">
        <property type="protein sequence ID" value="KAF5339488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000064">
        <property type="protein sequence ID" value="KAF5353150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CD07"/>
    <dbReference type="SMR" id="A0A8H5CD07"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5339471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5339488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5353088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5353150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="137" mass="15341" checksum="A77F06F8C9ACC978" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLAAKSSARKTAAAAGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDG5</accession>
    <name>A0A8H5CDG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000188">
        <property type="protein sequence ID" value="KAF5339061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDG5"/>
    <dbReference type="OrthoDB" id="2929273at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="347" mass="39603" checksum="8A631308658B7B17" modified="2022-01-19" version="1">MHIPSIAEIVKKIAKRIENSGHAVKELKTFSEQGIHDLEPPSGYLQEWILQARWEPDQKWSLDGQIKYESELDSIINGYLSSYCLTYRGFRVCPQWSYQPPTKDLKSLKEMYDWSMYAVDPESDSSESEGLLGDFEQEFALRPVTSTPPRPCSSSSSVLTSPSRTRALPPFGLDPLPLSQPVVWPRLSQLSDTPQSKKQIVDDLPLGDQSTFVQFVFDSLGRAVDPKSRIVGRPDFVVTLQMWDGTKKAIIVVEDKIRNKGKAKRQLQQYMKDLYTGDSQPILGMAFVLDRKGLRVALLRRSENEQVEQLEERSGAKREIWFSPLDEFVHRQVVEVVEQALRDRGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CDW1</accession>
    <name>A0A8H5CDW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CDW1"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="583" mass="65721" checksum="917215F9ABF9C37F" modified="2022-01-19" version="1">MRKFAAIADLRLSSTVPFRKMAQSSIPFPPEILEKIFACLIVRSCMHIFNGLEVLKPSSRSDLLACALSSRNFFDPAIRILWYSVELMPLLKLLPDFKMKNGTYVCTGKLNDKSLERFDFYSRNVGQLFLRKQDGVSSSDALTSVSNSAYNCVALARPRPLPNLTHFYCSAETFHSKAMVFMVSSSLKSASFYHSIGSEVIKYLSQVDAKPLQSLTISCRNGGNSYLPSISQHKNLRSLDLALFHCPAAISLDLLPLYCLEHLESLRLDLRNTKLKSSSMQYLSDSLPSPKALKQLRLLVDHQNVVAASTLLKLYEHSPLEVLHFGVFLEEKQCKAVFSAIPSLWATTLTTLFINLGGGLIVPRTHTPDSLSSFIAPLYRLRALKEFSIRINGMIGDPFHLTDTDILKISEVWPNLTELMLGGIEPQSGCLGRAPTVASLPILARNCPNLEVLNLPFDVRHVPRINKAKPRIPYSPGSGHKLKHLTLNVLEDDFDICNLADRPAMFAYHLDMVFPFLEEVVLARLNYYDVEEEPWDAVNGILELCLWHHSSDKIPIVYYRNCEVDRASEHEVFTTIQVYNEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE40</accession>
    <name>A0A8H5CE40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000190">
        <property type="protein sequence ID" value="KAF5338842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE40"/>
    <dbReference type="OrthoDB" id="2552978at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5338842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="91" mass="9931" checksum="35EFE0DE204AFAF5" modified="2022-01-19" version="1">MEEVREDRLKARMSEDGESAEQEDVWGGSDEEPDEPQKEIMRRTTKSILASPNPAQLEMGILANHGGDKRFAFLRDVDGGNGNGLGGLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE51</accession>
    <name>A0A8H5CE51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE51"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="131"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="230"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="363"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5340084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="61472" checksum="884151501C1700A4" modified="2022-01-19" version="1">MLSDIDLNSVDVKKEFAEETAGWTGYVEWEKYPEKKALAKRILDTKKFTPIPEFQFVPLPDTNPVLIGHRWKEYHEVLGLKGIVDFSWETVQKEKPDMIHLLDFPYNGETRRDQLMEGKITSNKCHFIRNHGGVPDINEDVFEIEVGGLVKNPVKISFKDLKDPSKFPQETVTVTLQCSGTRRIEQIQQYPGDGDELINAPWGEGAMYVDLLVTASDISLLLTLNHIPTSGTAVYRGVALKKVLKIACGGILPECKHLEFIGADTYFKKNNVYNYAVSVPWRKVRHNEEVLLAWEMNGEPLPKIHGYPLRVVVTGYIGARSCKWVYRINALAEPSLGPVQSQEYLYYTPQIGKQNVKYSNGFSIQAMPVSSAIIFPLDKQVIVHDGKVTLKGWAYSGGGNWVQRVEVSNDGGSVWYAVPEENMTQKHYHAWRLWKIDLPTDAEGWLEFCVRTWDSSNNTEPTFVRSAWNWDLHVTSSCHRIKIYSVNRSRPDTAKRLKVLEEHGADVHNLTKPAEFELEDLNEFLEYRRKYPREPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CG70</accession>
    <name>A0A8H5CG70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deuterolysin</fullName>
            <ecNumber evidence="3">3.4.24.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D9758_014978</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CG70"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034725782" description="deuterolysin" evidence="15">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF5340178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="340" mass="35774" checksum="04385A24A8C341D3" modified="2022-01-19" version="1">MMFTTIPIVTLLAGLAAANPVKRAGTEGLTVKLTPASSSISSIDDLKLVAEVTNTGSEEVKVLKYSTILDSLPTRSFSVSKNGTDIAFTGIKATVKDVNAAFITIGSGETVKVTHSVANIFDFATAGAGTFSFTPRADFKIAGAGSSAVKVSVNVPTVDVEVTGAISRKARRATNVCDDADKASFIDQAVTEGTELASIAADYITSGDGDSLFEDYYGSNSPSTVADIFSAVANENDSGRELSCDDQENVCDGNVIAYTIFFCDIFFDEVANERLCSGTSVASRNIRGGTFLHEMTHALADTDDIIYGCADDRALSPSEAVQNADNYNCFSTQVYADTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJD4</accession>
    <name>A0A8H5CJD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJD4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034897211" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5342814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="36106" checksum="9C1D781930A691BF" modified="2022-01-19" version="1">MKSFTVILSAFALVTRSQTVNYSGTITLGNSAGNCIRAVNNSDNAAVVLSNVCAGADAQWTFSNGNVRIFGNKCLDVTNGNDVNGQQLQIYTCFQGNTNQLFQYQDNHIAWSGRGRCLDNTDGNLTPGSPIQLWSCISYNTNQRFNWQTTPAAQGGAQPAAVPAAAVGPVATVVVVLQPAGAAPVAVQTVNPQAPTTVTVTARVGTTTVTLPGGSVTTVTTTIPITTTTINRNATTTSGITTTTGNATTTTGITTTTGNVTTTTGITTTTGNATTTTGTTTTTGTGTTTAGTTSGTGTTTVTDTTATGTGTTITGTTTTTGTTTVPTTSGTTTTTGTTTVPTTSGTTTTAPTTTAPTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJQ3</accession>
    <name>A0A8H5CJQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000151">
        <property type="protein sequence ID" value="KAF5342990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJQ3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="74" mass="7696" checksum="165317A7695C3BF2" modified="2022-01-19" version="1">MTTVLLSSQTYASVSSGLFWSHLLSEEMWSMEGEGEGGSLAGPYGPKGTSGLVFGFGFGFGGALVLTTNRLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJV5</accession>
    <name>A0A8H5CJV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJV5"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5343065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="985" mass="106811" checksum="6636C46ACB2A7175" modified="2022-01-19" version="1">MPSLTVPNVEHPFEPQPSTSSQSHGKLRAQLQNLLPRHALFYAKIEIHQITSVPLVYGEFAVRWRFKHAQNKLALKKILKSRIQGRKDKVEEGGADEENEKEDSQGTPIPSVIVSDVAQHMGYTGLTSHITTSPSPLASRSPSYQSSSTASSTSTSIPSAVLTHSNLTHFLSTPSTSTSASFSSSALASNPGSLTSSLSGTPNNHNHTSSHLPHTPNNSPNPSTLQRIIPSDISTYSPSRGITSYNKLVDHSVSWNHVLHTVLKIPIDRETNMLEPSPLKLVVTQRVVHGDPDAPKQPRLGAIYLDLSEYAGVGGEVERRYLLAECRMNVVIKLTTHLVPLTPDIHYTCPPLPKAEILNGVTDILDTDIDIFHTRPRGLDLWGPFFRDHDLEGAHTHAHEEEDEEDISHAHISSEKRTRSTPSMNGSPNSKTRTYLDKGKGKEKEKDHRSRSRSRARNASGHSHRAYSWARKFGLDFSDTDGSEDFGSEEDEDEDGIEYASSPEEEEDDEEYVEGLHMRDAVDVSGATATSASASSSRTQRSKSSTTSKSSYSDASGSHSHEHHGHPHSHHHHPHNHHSNHRHHSNSHTPLARTQVKSTSPKKNQNHAQKKGQKSPPGPAIDSVFDVSKLPLAYGPKTTELLIDALFNPVTVVVPKADAHGDHSKGKDKESEALMSVRTSSTENRDKTPIPLGHGQDDDKSPKLPLSSMMSAVDGPYTPFTTIVEVEEDEVKKRAKDLEGYEVHIGDGDGDQHLEDDSLAHHAQDIHLQDGIPVPIVDRNRTVRRRKTDTNSGDLPLGSMYSAGSPRTSIENDRVSSKSSSASTRSGSGSFSGSGSRPGSRLGSHDGHGDGVEGYGHAQGQDRRGRGLGMNVRGWWSKMRLGQQGPGGQDTVSVLGAAVIVAAVGSPGSIELSSRPGIPAAMTSGEEEKMVMGTNTGRNDASTSQSQGGLLGLGLRLGSSNSVSQLPFFFNVVVVVFLLLMSHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CL97</accession>
    <name>A0A8H5CL97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000133">
        <property type="protein sequence ID" value="KAF5343800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CL97"/>
    <dbReference type="OrthoDB" id="3023255at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="26881" checksum="A0990627ACE6E96E" modified="2022-01-19" version="1">MCICTLPALLQPTPNINNSNSRMSSFSQVSSLSADELTLVSQKLANAFSNLCIRIHLDPLFRAILGEPPSSESKLAVDFFKAHILAGLQYGAVYTAGENLAALAVVFGPGTKMDYDKSAEWQDLLGRIPEENRLWYESEFNDQCTKFSNDAYGKGNQHKWWYLMVLGVEASAQNQGLGKELVNGLQRVAEESNVPLCWQTTTAPLFYQHLGFEAVRKIKYSSPSGDIEEWAYVYQPPTVDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLR6</accession>
    <name>A0A8H5CLR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000133">
        <property type="protein sequence ID" value="KAF5343803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLR6"/>
    <dbReference type="OrthoDB" id="2935717at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034986646" evidence="2">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="263" mass="29470" checksum="DB0F29A8763420D6" modified="2022-01-19" version="1">MQILKLSKFVAFSLTITGIFAGSCETFNFRADGGRALCSRDAAYKWDGKSTSVTKEYDDHVDAKNTCDHVLQLNIAIQVIKSRFCPSLDDSRLSNEEKTSSLEKLKNIINKGESPSERNTFFVTEDVDALKGRAVEIWNEKNQFLPKMYLVSEKINKSPYSPQKLIATGDYLSKTGANSVEVAIRLDTAMKKEAAKSRSSEQKKRGFTLKTKDKLGKDIRSTEDTWRAFLKWYEEVVTEAEKEMNTAAQASNSRSKDSGSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMC0</accession>
    <name>A0A8H5CMC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000126">
        <property type="protein sequence ID" value="KAF5344375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMC0"/>
    <dbReference type="OrthoDB" id="2984821at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5344375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="230" mass="25203" checksum="3BBA71B629D84A08" modified="2022-01-19" version="1">MQPLTHTRSTSIHKAISQALSASEPKSITVAHILPIYIRFAGFDKLCHDALVAFEHAMEKGRVVGSSITPPDATDGDDIHQAYPDLVKGMLNTWQLEAAVIKLREEYWKKKLGGGQGGEGTSVCTCEECGRMRLVKPTEREYYDEGGSRYVVMKAKDLKLVSGEGGANGSATTIGPNANSRTKRKVKKAKKTKMKKKKFVQGVTVPSYEALHAFTNFQVHRAINTLPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CMW9</accession>
    <name>A0A8H5CMW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000138">
        <property type="protein sequence ID" value="KAF5343552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CMW9"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21149" checksum="B52CAAF5D6210973" modified="2022-01-19" version="1">MLKELALHGRMDGIDGDISTYGTLKLPALKYLHITSPFPPCHITSGLAVLTPALEYLRLSVPEHAEAYVSELQGVLRSTVSGCSGADGDKAAAQDTPALQLRTVLLHCPSKPRDNWMNQLDNYERQMHLLHKLKAEHAQTGLVKLAPPLKRSMFRTVTIKDAEEAWRARVLGRDAWWEDSKELGAFSDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQL1</accession>
    <name>A0A8H5CQL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_009920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQL1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5346172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="360" mass="40316" checksum="2D2E12C91CD7174D" modified="2022-01-19" version="1">MAEKPKPPNPFLLVGLSAASFFAFYLVLKRREQTNPASKLPRQQDHPLVPPVQQDDLNRTTKDNQPTNQYYEGQDQYALNKMPAILHKIAHALHLDGRGHKKTKSKASLKDVKGKEKEKEQVKDKDNGKGKVEAVAQEETSTTTRAFDSEKVKVVFVLGGPGAGKGTQCKRLVEDFGFCHLSAGDLLRAEQNRPGSEYGQLIRDCIKEGSLVPVEVTITLLKNAMSDALKENREGSGESWKDGKGLFLVDGFPREMDQAERFEKQLRPLATVLCTPSIVLYFTTTEEVMLFRLLERGKTSGREDDNEESIKKRFRTYKEQTMPVIEHYGKVGKVAEIDSSASVEEVHKRASEGLKKVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CR07</accession>
    <name>A0A8H5CR07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000112">
        <property type="protein sequence ID" value="KAF5345458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CR07"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034351219" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="579" mass="62636" checksum="94901A50E7E8B182" modified="2022-01-19" version="1">MTPALLLLFAFSTWTSVFGAGPTVSIGDFMFVGRQTSENVEFFGGVPFAEPPIDNLRLKPPVLKTFSSGQHIVFNATQFGPSCVQTLVPVDEVSEDCLSLSIFRPANLELDQAKGDGLAVMVWFYGGGFIVGSSSMYDGTPLVNRSVFRGTPTIFVAANYRLGPLGFPRGDDVAREAAAGSRVLNLGLQDNIAALQWIQKHIASFGGNPSKVTVFGESAGARAIEVLLLSNQIQGLARGAIMESTGGTPPISATSSTANAAWDNFMAVLPQCANTSGTNVECIRHLKTSELIEGFINDRIFFNATISAGNPWGPTLDDDIIPSFPSTLKPDHGVLEAVIIGCNKDEATLFTVQTVNSTQAISDKILGSPPSPPDASPSQRKVQLQKLHHILEETLALYPNIPSLGSPFDTGNETFGLDPEYKRSAAVSTDMGFQAERRFHINHQLLPAGISAFSYLFTDPDAVPVQDFVTGMPVPGSLGATHSSEIFYVFGTLAERPEVKEVTPTAAKLSDMMMDYWISFANTLNPNDGKGSTRPNWPEYTSNRQELMQLNGHNTTAIKDDFRERQIAFFNRDPTVFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRE8</accession>
    <name>A0A8H5CRE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRE8"/>
    <dbReference type="OrthoDB" id="3265563at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="20750" checksum="3869B0B03AECAFB8" modified="2022-01-19" version="1">MASKRFIPSSLSTDHPYQGLALVRTIILAIEIKPMITNDFDMLGRGTMARVDILGTPILISFLAVNLLTNLFIPFMIAGRIWWIGRQVSKSIGKRKNSLTRRAIAICLESGMMYPLVLIPTLAWIGPDLIPVLTQVVGIAPTFIIVRVALGVSIENVEDTVAKEKEGNGGHQTRTLMTIFDDDASTGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRQ8</accession>
    <name>A0A8H5CRQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000099">
        <property type="protein sequence ID" value="KAF5346804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRQ8"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="12737" checksum="79F59853619CF199" modified="2022-01-19" version="1">MSSDISGFWIYQSLQKAGVEIKPSSGPSSLQDELDEYFQITSSCAKMSINPLEWWYARREQFPHLYRFAHDVLCIPGSAVAVDLKADTIQALMVVKAQLRMARIAIIEILGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS32</accession>
    <name>A0A8H5CS32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_015137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000110">
        <property type="protein sequence ID" value="KAF5345622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS32"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="28"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="567" mass="60514" checksum="D7E8578C0819E6B2" modified="2022-01-19" version="1">MGHALMISTNVQLCKARPAPILTSLAMPHNIAIVGISVEIPGGDTYNKNLDHASFFEFLLKSGQSYTNIPNDRFNIDAWHGPNVGKISTQKGSFLKDIELFDNVEFGVSLKDARAMAPATRKVLEHSFLALYDSGIDYRAQNVGCPNAGSTYDILTVAEPDHFDAEGSFAGAPAMMSNRVSYHLDLRGPSIPSDTACSSTCTAMHIAINSIICGDCDAAVVAGCQLAHQFTDWFNYSEGHVLSKDGKCKPFDASADGFSRGEAVAAIVLKPLQDAVRDGDHVYAVVQGTAVNAAGSLGPPNAPVAEAQQDAMLKAFHRSKRSPQEVDYVECHATGTAKGDPTEVNWVGRQYGRNDQLTIGSVKGNVGHTEICSFLVSLSKVLSMFEHGVIPPNVNLSTLNPAIDWEAYKLQVPLTISPLSCRSGTTSLVGMASSGIGGSNAHVVLESPPIHSTVDTCYDVSKPALFVAGGLSPRSANSIMTSALQAAAKNPKVIGDLAVHLGRRARQMTWRTFTLVSKEQALSVEFPSPVLAPQARPKVVFVFSGQGPQYSDMGRELLRGLLKAELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSE1</accession>
    <name>A0A8H5CSE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_011903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CSE1"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5345787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="61798" checksum="E0BB5C747F622141" modified="2022-01-19" version="1">MHSVKDYRLQTQKLSTERDEAIVRATRGLESVKGARERRANVSTMQVRVDELKAGLAKLRKDNDKKRARLQSLRETLATRRQALSAAKIQSSSNFAPPSTSITMPGSLPGLSSSIHALPPSPSSNTSSSLTPLINQYNTSLAQLHNALHLARTALIAELVEVFNIVQLGGRPSMNGRPGVSGEWSIANLVLPVPGDVKRYPTEHINAVLTNTIRFVELVGFYLGVKMPFQVTWSGRKLGVGVPWIGSIRGYGGSSGEWARWHSKYPLHLTNSSSPLLPPQASESEGDADADSSESTEYEYLTISPERKSKSKRATDAVDVDRTPTQSTIISSSPAAPTSTSTFTQKEDLADSVLHTTAKDRDITVPSFTTALAMLIYNVSYLAYTQNVDIPLAQAGDVLGNLWAVCCSPELGRRSHETRLFLPPPTPPQFQLDFGQLLQATARGPKRREAVMRRFSTSTASSNSSAPTSPPATSLTGTRSSSSSISASTTVAPFPADSPTSTPGSSGRPRPALVSMPGSPSSNSSRRRSSVSLAKDVIRSGRWGRDRDRDKPPTEEEEWDLVEEEDEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTA8</accession>
    <name>A0A8H5CTA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000104">
        <property type="protein sequence ID" value="KAF5346222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTA8"/>
    <dbReference type="OrthoDB" id="5378718at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040887">
        <property type="entry name" value="AUDH_Cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054583">
        <property type="entry name" value="Beta-prop_AUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22301">
        <property type="entry name" value="AUDH_beta_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18637">
        <property type="entry name" value="AUDH_Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldos-2-ulose dehydratase beta-propeller" evidence="2">
        <location>
            <begin position="126"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin" evidence="1">
        <location>
            <begin position="463"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5346222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="87452" checksum="C8C39E84CAE0B102" modified="2022-01-19" version="1">MCCTCRALSAAPDVDSNNEHVNEIPIATPLPDGYWIEAFPFKTDASTPDIIAYGLGFKGKPAAIKLLTNPINTSSGGWKVNEITSLDFPVGMTYADLTGDGYNDVIICDRYGPSMDDLWSAETNDGGRIQWLRNPGDRSAPDSWEAHSIGNSTGMHRIQAGHFTTAEHVQVMGLPIIPKSSDLTSPAPILIFTPVYGSDDHKKGPDRWTKDVAFASQFRLIHDVRLLPRSNGNLDSILVAGREGIALLWYDTAKKSWQHNIVGTGLPQSGENPYWGSGSVDVCRIGDEQIGYIATCEGFHGNSVAVYLRKPNAPKGVEALKDSSHWERKVIQSFGELNAKYTGTIHHIKAVQTPTTHVVESFAIACMGAQRNQGVYVYTPEEKDGNITSEFRETKVTNESAGRLAIGNFSHPSDKVIYFADFENHTYLPIQEIASISYYVPNYHTGPDPPAVRINTISPQNLNIVVSRLNNEVLLRIPRPNAIPPGENRSLPFWILAGRKIKLVVVPPCGEYRLAQCDAVKVIYGSITYDVNGAQITRGIAPAAKDIGETQVPSIINAGDKGAVFIHLEPLSDHAQGPFQTMSEVSSLNILPNNPHVDPSARTLQLPFRKVETLSWAQNGLWDNFEFYNVTGFHIHFNDDSFERIVHTQAWTLGLGETARFHNHSDQSFCEIHYCLSNGGGKGGMRYFADDYTDPIDTDAELTKEYVEKNSTLLVVPDMHEHGPLWKIQQGNQAKPKLRPNGTVDYPWHAWLASQFGDRKLPIIPPLPANEQKYDVWMAFEFPLTAFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUP9</accession>
    <name>A0A8H5CUP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUP9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="87" mass="9401" checksum="592C28C6FF19BAE1" modified="2022-01-19" version="1">MLGLEILRANKPSTFKPSFPRSRFSQDLESIAVTTDVGYHVGYLDSGLLDGRVITVEAGSRHGGNLEERNDLALAALPWQTPTSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CV09</accession>
    <name>A0A8H5CV09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CV09"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5347859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="175" mass="19629" checksum="5D21C10B6DE7B070" modified="2022-01-19" version="1">MYPKWDDFDEYRERAVELHLEWLKERERQGRWKTTSTSKSSPGPSQGRMVASVNALMGSGANSSFNLPPKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPSHAIRTAETASPPPVTVAQASSSRNTIKDISDMVNRVKGLEGEEKEQATVYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D152</accession>
    <name>A0A8H5D152_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000073">
        <property type="protein sequence ID" value="KAF5350791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D152"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5350791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="40756" checksum="0FA1145EBAFFF57F" modified="2022-01-19" version="1">MNPFSTSIYAHHIMSTPTVVCQCGPIPKDAELPFWPNDSGLITISFFGGTDAQKNIIKKAFEEYATYANITFNYKEDNASDADLRIAFTTGKALSAIGKNAAKVPKEQPTMDLGAITGNTDDVSVKSDRAVVLHQIGHALGLRHEFDDTKAIVESNFHKVDVKSVMSTTQTGAIVGNSELSNFDKALLLVVYPGKTPAYGEDLTWNVDLALQVLRFPEDVKREISNSKDIAKTRTIYATYVSKELAKIYPVGPTPPPGPKTDELDPILALALIHPSFRETVTRMVESDLRSRGQKLRPRPVEQSSADSAVPAEFVQALIAQLAMGGGASIGVQQGINGGAVSRPLPPDIQQGIFGAVLSMLKNPIFHNVVGSVVKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D2D3</accession>
    <name>A0A8H5D2D3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000066">
        <property type="protein sequence ID" value="KAF5352311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D2D3"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5352311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="193" mass="21338" checksum="9FA16FC34673F1EB" modified="2022-01-19" version="1">MACSLNTVPASHWGRKATRWQFAIVDGQKLRNNQRGCAIFLFFFRHDPGYVIGHMEEDDETSQVVPPWVELEYAAGSNLAHMGTLADQGSLVHLTHLSSSSELLKAKFANVPYGGENLAKTSCHQAEVLNLIKEHICGSLRKVCLLDPEAEQELLPEDGDGGLSAFCLVVFWVTNHLETERLDCVSLTSLDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D682</accession>
    <name>A0A8H5D682_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D682"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF45">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5354351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31275" checksum="26B53A9B7BA9547A" modified="2022-01-19" version="1">MTSKNNSLATINELIAGSVGGAAQVLVGQPLDTVKTRAQIAPKGMFKGPMDIVSQTIRKEGFFALYKGMLSPLIGIAGVNSLLFASYGISKRIISPYPQLSLPETALAGSMAGAANAILASPVEMFKVRMQGQYGGASDKRLSAIASEMWKDWGFRKGIMRGYWVTVAREIPAYAGFYTAYEFSKRKFTAIYGSQLPIWALLASGSTGGIAYWLSCYPLDVIKSRIQLRPIPPTGTPVQYIAAEFKAILAESGMKGLFNGLSPSLLRSIPAAASTFAAFEITREYLAGITGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D8B7</accession>
    <name>A0A8H5D8B7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000058">
        <property type="protein sequence ID" value="KAF5354593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D8B7"/>
    <dbReference type="OrthoDB" id="3038990at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5354593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="487" mass="54506" checksum="C87435E452604405" modified="2022-01-19" version="1">MNNLVCDPILMLCQNDRNIMILIMVFDPPRLLADDLVDVVSVRNMYIRNRVSSENAPFLPSQSIMSNSTVSEPVLGELWDQLRITIYFAVGTAGMALWDIAVNLENDYRILSRKMFAIPTLAYFVSRFSMLGVALSQAIFLTLPTTRCEELNRIMLTFLFVSVTTTTLLFYLRLKAIYQHSRIMVVSFFIFWLVTVGFSIPIIWQGTVSTIPDPISHRPQCFYSGFDMTTGILGLNAILVHDSLVFVAVSYRLFKNSYLDLDMMERTRTTGSCGGSDTASEYSLRLTRTISRTREFISGKNLPAFSRALLRNGQVYYLLSLFATIITNVIAWAPFLSIPQTNFPGVHVMLFIPHATIISACSCHVFRQVRFGLIREHDERATPSLPIWSSGKLAVGRGGERGKVKVGNGGLTLTEIDSYDSAMDSRRSSLTEGGESGGRPACYIHRTVERFVDDVDVDVPGPLPAFTTAKMHRRATVSEWKGPVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAM7</accession>
    <name>A0A8H5FAM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000339">
        <property type="protein sequence ID" value="KAF5329920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAM7"/>
    <dbReference type="OrthoDB" id="3255824at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5329920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="15940" checksum="C9596851D7B9F214" modified="2022-01-19" version="1">MKEDLEWWLEQLQLLFLGLHIIKPPAIDTSISLYVDTSTLWGIGLILNNKWLAWQFKEGWQGDGQHIGWAEMFAIKLAILTLISSRIHHTHIRIYSDNQGVVRALHACYSRGKEPECFSLSYCLLHAATFYLAVGRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FC16</accession>
    <name>A0A8H5FC16_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000322">
        <property type="protein sequence ID" value="KAF5331510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FC16"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5331510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21091" checksum="2333FC7B1A52C46A" modified="2022-01-19" version="1">MGEGSLEGADLDEWNITKADMTKCRKCTAMRPEVSIPPRRRVEYKADVSVSSPNGESASLAYLWLSTVLFVLLGYPLFFEALGLRVELCEESRVESGEMFGNGYDLGPLYTLLLSLRILPYTDGRAWARRRWSESESDSVFRPKQNDGGEGEGEVANGHGNGDGRPRQGGRAQMSAHRGVRRGEELTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FE66</accession>
    <name>A0A8H5FE66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000285">
        <property type="protein sequence ID" value="KAF5333820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FE66"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5333820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33937" checksum="54F41CBA003FBCBD" modified="2022-01-19" version="1">MKVLKTIQRLLDALQATYPGLSMFPDPTFTQHDRRDIVMELVDTERAHVSYLQLILDSVATLSCASNFMQSTLEPLVINDNWLSMRQYHDRVLKDMEAMLLRMERSDFNGDAEDWLHIFGFGNPANRTNIAATYRSLSSRRLAGNIQILLDVLSILPARIADYCAWLQAILDYTLPSLPVLPTSSFSSPPSCFDTVCTTLYHMSQISSAIDKMSWQIQSIQALRTLNQRAFHWNASIDPSQLGNLLVDDQLEIYEADSGTGLKPKPKDEAAKTYQVFLFETMLLCQSPEQSLGSSPPLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FF95</accession>
    <name>A0A8H5FF95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000249">
        <property type="protein sequence ID" value="KAF5335020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FF95"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="272" mass="31156" checksum="190225C91CCCDEAD" modified="2022-01-19" version="1">MSTDTIPTRIIMIGVGGATSSGKTTLAKHLQNCLHDSFIIHQDDFVPPAENLPVDPEYGFANWDDAPGAIDWDRMAAFLSDLKKGGILPSNHQSYDSFNETRTVPVDDDQIVQWRLQSEQVAAIHQEKYGEKLIWALIDGFLLYWDERIISNLDVRAFIRVPEDIAKSRREARSYHTPGEQYLFWLSMYMVLIWEIEGDVWRDPPEYWEKVVWPAYIRAHKHIFEGEDIMGNLNGKVKELVLLESTEASMQQMVNVVIEKILDFSAGTGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKX0</accession>
    <name>A0A8H5FKX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000179">
        <property type="protein sequence ID" value="KAF5340123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKX0"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="22168" checksum="469A41FDBC0DD45C" modified="2022-01-19" version="1" fragment="single">MRLLNTKTLKLEEFYTDIPPYAILSHTWEKEEVTFQDVQNLKVAKQKAGYAKIQNACVHARKYDFEWIWIDSCCINKESSAELSEAINSMYQYYEDAKVCYVYLCDVSAEYHPRNPKSRFRDSRWFKRGWTLQELLAPLYVVFLDKDWERIGTRWSLRDVVSAITSIPEQVFEGCDIEQYSVAQRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FMW3</accession>
    <name>A0A8H5FMW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000159">
        <property type="protein sequence ID" value="KAF5342719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FMW3"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5342719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="40574" checksum="C92063C80F1552DA" modified="2022-01-19" version="1">METGDQQLIELANECKTKYTFPQPVRTDFFKVQVTVIVVFTKYDLLCAEKSKQRRKKFPSEEAAVRKGNADTDATADLEKRVDDYTDFDFNSVKWVSVSTFAKYSDAARRLGMLRTLTKVTRKCLHDVEGDLLVPWVAAQQINAQQKVNYSIDEGFKKYWMDLGKCTIFEGQVLWDCISRIHRDVLVVWNFYDLNQLLSGQEFCADMVKLIEPLLIHSESQSDILPQTSDLVSIASTIAAAFAQVLAAAGIAASVVKFLYERYQKSSLTALCFGTYIVDLTLILHNLFIDTLFQEPPRPVTRDLIDATLQAYKASEASRVWHELIRKIVYQPSTLLRPEEKIADLIREELGMKTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNY3</accession>
    <name>A0A8H5FNY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000134">
        <property type="protein sequence ID" value="KAF5343766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNY3"/>
    <dbReference type="OrthoDB" id="3263746at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5343766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="820" mass="92583" checksum="6B7EF1B3689B28F2" modified="2022-01-19" version="1">MPCVEVHNVITEPCVGSGQEIGGHFQLTDVGTNDGSIQSEEVPVVEFWTVSTTPDRTLSHTAESITAASAQQDNREKMVPLVEETGFDDWARYASGQAAQSGEHFSMREVGKDEIRSSLDNEVASPEMMSVQDSDSDVDVAVASTLNPGLLVNHSAEMENVVMAWEVMDGATEDVVGVDQHDQGVMVRDVNIREPVVKVASLDGFTSRGDSLGESPGVEISDVYATSPLRTGVKEGPADDVAMDSSPEARDEYWTERLALWNGGVSMRSDVEDSESDADCPEEDSADGEVSDDQIDFDDDAMVIVADLDERPTVVPPIFDHSIDAEIFPNFTTDDSPLVDLPLEPLVHVEDIRPGGMHNNGDTLRQRSKASGSGSRITSSLPQPIVVQSPPPIQEYDHFWDSEQEEPTENLSTRLRRERSRRSRSGSKGSAKARNVPTRERNGITDTARDDTQLRSEDVNALKTEIKRLLEDVLEDATSLYNHFCNLLESNMYTSKDILALVHACIVHCQATKLQPKRGLQREESRSKSQSTTSTEVDDKEKQYRPYDKVKTARAVREVARLLLQPEGEALRSATRNEVLAFNNCKHSGPTEQYFILDFWSKGIWNTWNQQATDLFVNLMKRIPEYEKYYEEHIHDAFRTHLRQLQRRFMQPSHVPKSQAVSEKEQELRRDQRQRRLLERRLNAIDRFSNKFPDAMKHIQGLKRYLKKDVMSDDETSDEGPGKVNIKKMDWRAQQLEDMLRRLCALHLSFKYCHNGKYKPGAFPEARYPSGLQDRTREQAPARLPINFYDEVWLNDPAYPNRKASLRPKPAVDLSLTEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP93</accession>
    <name>A0A8H5FP93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_008876</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Plastid</location>
            <location evidence="14">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP93"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="G" evidence="17">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="250"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5344096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="397" mass="45107" checksum="377D6CCFCCE01573" modified="2022-01-19" version="1">MTSSSYPQDKVENTRDSLDDDWDSPLPSRGQQDDVVIAVMGCTGTGKSSFIRRLTGNTEVTVGNSLESETSEVKVICYRDPGSGRNVKIVDTPGFDDSRLGSSGNTDTDILKKIAEFLVSEYDQNRKLSGLVYVHRISDPRFGGQSVRNLRMFRELCGTQNYKNVIILTTFWDKVDASEGQMREEQLRSNFCKDIVAGGARLMRHDCTVAGAHQVVKAILPLPPTTVQIQVEIREEGKSLEDTGAGSVHREEMDRLIAKHKKEMDDLKTEFRSIERSNEEARRALKEERDKLQLELQRWQKEKEDLHKGLEEEKLREKQAAEAIEEKRRRDETARLLEEERRKRMDAELALNAERTRSFAQRGKDFARDVPLCPTFLCETPLTVGGHILDAVKGIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQL3</accession>
    <name>A0A8H5FQL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAIB/BAIF family enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000111">
        <property type="protein sequence ID" value="KAF5345539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQL3"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48913" checksum="D8C59EB9E45C865A" modified="2022-01-19" version="1">MLSLALRPSRALVPTCRRARQCVRHIQVSSSEPGASGAGMPPPLKGIKILDLTRILAGPTSTMLLADLGADVIKVEQIGKGDDTRTWNPPSAPMLPGHLMPEETRDLPAESAYFLAINRNKRSMTIDFKSLNGQEILRKLVAQSDILVENFISGKLAEIGMGWEDCHKINPRLIYASITGYGQTGPYRKAAGYDVIIEGEAGLMHITGEPDRPPSKVGVAATDVATGLYAHGAIMAALISRQQTGKGVWIDCNLFESQLAGLANIGSNYLIAGLEASRYGTAHTSVVPYQAFPCKDGFIIIGAGSDKQFVTLCRILNLPDLSTDPRFLSNALRVTNRDTLINILSNKLMEENREVWLEKFVGAGVPYGPINNIKQTFEHPQAVARNVTVEVHHPRAGKIKLVGPAVTYNGQKMPVTRPPPWLSQHTEEILTELGYTAESIRELRKAKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FRG7</accession>
    <name>A0A8H5FRG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FRG7"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="576"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5346915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="766" mass="85527" checksum="861C826FA827E83E" modified="2022-01-19" version="1">MSCLFLCGFMEVDYTKDTSTKGRMNQTLTLNLYCIVIIIVFGFALSEALRETNDLNVGLKDQRLALEWVKENIGSFGGNPDKVTIFGQSSGTLSVTMQILAYGGTQGAPFHGAIMESTALEPTSTLNLTLDAFNAVANLTGCDTFGNPQGSETLSQNGGDVYLPTADGDFLPSTSSQLVRQGRFVQMPVSIIGWTEDDATFFMPPNKTMEEFPDTFYPDPNQTTIEILLELYPLDDFTANAEAGLPAEFYRSAQVFRDILFVCPSFLFGHAIADKYNQDLANGHPEGQSEPEPKVIPPVFLYAFNQTILTSSLEAIDSPGLGVIYTSELVCVFANFTAYNVLGLVKPTESDFNLLEQVSRSFTGFANTGVSTIPGKDMLKGWAGSYLPGAEMMDASVYVVGGSNPGMSTLEGEGSVLNCGRTMLQVLFEYYWQWQRVNVIQYRGVISYGQRRLHRLPFFTPSPSPPHSHFLFNLYTMSTTTPASAPAPATDPNWKPKPGHVGNLSPEQQKALDTFRDELKQEGAFVEERMDDPFLLRFLRARKFDVPLAKTMLLAAEQWRKDFGVEEIVKNFDYKEKEEVDKYYPQFYHKTDKEGRPIYIERFGSLDITKLYKCTTQERQLQRLVWEYEKSISTRLPACSSSSGHPVETFCTILDLRGVTLRAFWNVKDFVMQASKIGQDRYPETMGKFYIVGAPYLFGTVWSVVKRWLDEVTVAKISVLSGDVKDWKGTLLETIEPENLPHYLGGVCDCQDKGGCSMSDAGPWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FS21</accession>
    <name>A0A8H5FS21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_011625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JAACJM010000097">
        <property type="protein sequence ID" value="KAF5347036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FS21"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5347036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="530" mass="59249" checksum="DF0D624AEDAB111B" modified="2022-01-19" version="1">MIEPRHGTRTQLSESFRPTIMVFGHLLSKLSGFLFITSVIASVQHPFQTESNVNHSESWSTSSSRNGGSWSDDGLFTPLESLSVLKTDEFTTMNHPAFPKYGVRIKKSDFCDNTVNAYTGYIDIEARHIFFYFFESRNDPAKDDVIFWTNGGPGCSSSMGLFFELGPCRVLDEDGPKFHPESWNSNVNIFFVDQPIGTGFSYADYGESVTTSEEAAKDIAAFVAIFFENFGQFKGRAFHMAGESYGGRHVPLFTSAVYDQNARLVEAGMTPINLTSMMIGNGLTDIYSMNTAYYEMTCTSASRAPVLDIATCVGMKQMLSRCEKWTKESCIDQYDSISCGAAQAFCDSAISAPFLTTGLNPYDISSPCEGGIESLCYPILKHISNFLDQPSTRKKLGVDPSFSTNFTSCNYQVIADFAFAQDILHPDTPYYVSALLERGVNILIYAGELDWVCNWLGNEMWTVALEWSGQDEFVKQPLEEWNINGKRAGKTRSWGKLTFATVEDAGHMAPYNKPKETLEMLKRWLTTFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSY5</accession>
    <name>A0A8H5FSY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSY5"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59764" checksum="8BD0C101C55E1779" modified="2022-01-19" version="1">MAGPSSNPRSFFLHTHGVDFVNTTANMVAGDMHVAYNYSDQGHGCKRKSPVVNRCTQRIVSQSNIELLDQLSSRRQYRIHSAKYKQRLVLVKVFQGTQAKKNFKEEKKQNQRLLHPSLLKMIGVSSFTTESPFIVYNFAPTRGSVESWLASVLEKDLSDILLLGCKIVSELAIGIDYLSSEGARTGSSSNKSIEIFITDDDVLKIVPDFGSLPIEDGGRHDESNIDPLWGLFNDLCIKTFKQATCILYPDIRNRRVSSTIAEVSSAPDPDPATDVLGDTKSLTSGVSSNLYFNELEGSASPRRELLWRESSGGSRSVHAVAEHYREFWEHLSLTVGQSYHSYAIPRKQAARPLRTVVHQCQGYRKEEITITSDVSENAIISHFIPSLYERCPVCKEIVEEEEFCCPCGGNDDGISPTIKCSRCGIWQHRSCAGHDNLLLQFSCSFCIPPATRSWPPQWLSSAMMHAKYPNDELQVTLRKFKSGNASPEWRIKCVDCPGKLYKPGPGKTLSNFEVHLKNRQHRQRVNDRVNGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTD9</accession>
    <name>A0A8H5FTD9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000086">
        <property type="protein sequence ID" value="KAF5348359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTD9"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42561" checksum="A1AB30F9BEB2C876" modified="2022-01-19" version="1">MTTKRLSRILNWMNPSSKDNKDTTKDNKDKAAVAVAKDWKNLPTFDDLPDFKGLKGCAWEVWGQDDELGTVNMLTDEVVKRAAVEEFVTGKCVSLNWPLNFPSSPLFGRKAPEVNMMNKYDRAAVRDDEIHINTQSGSQWDGLRHFGIQEHSVFYNNVHKDTLAVGVVPMSDPSNIDPLITKIGIQNWASHGICGRGVLLDLVKFFTEGSNDKKLPYNPWTTHGFTVADLEACAQKQGVKFRQGDILLVRAGFIQKYHTTSQEERDELIGKPETFAGIEQSEDMKRFLWNNHFAAIASDQPALERWPPPEGVLHMHQTILGLWGMPIGEMFDLEKLSEVCAETGRYTFFFSSWPLAIIGGCASPPNAAVSSIIFAEAELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FXW5</accession>
    <name>A0A8H5FXW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_007885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000065">
        <property type="protein sequence ID" value="KAF5352994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FXW5"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="795"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5352994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="945" mass="103828" checksum="248A7DF782958701" modified="2022-01-19" version="1">MAYSQPLSPQSLHPPFRDLNSNPPSAQRLRQLTKQRFVAELSQCLFDFVIQLLPTQEEMAVKEDVRKLLERLIRTIEPDSRLLSFGSTANGFSLRNSDMDLCCLIDSEERLAASDLVTMLGDLLERETKFRVKPLPHARIPIVKLSLDPSPGLPQGIACDIGFENRLALENTRLLMCYAMIDPTRVRTLVLFLKVWSKRRHVFNTSFLHFALTFALQENQLTLQRHIIIIWLCPSSDIFPCPRQKSACASKSSTNASTSPHIQSGHNTWFFDDVELLRQRWHSDNTESVAELLIDFFRYFSRDFPYHVGVASIRAGLLKKEVKGWQNELSGGRFNDARERNRICIEDPFETDFNVARCVTKDGLYTIRGEFMRASRILAVRPERAIIALADLCEERPDEELVTAPLHAPRQVPPQTPYGVGSRPLRSKAPPFAVPPLPAPVARLQESAIPSLVQEVSHTPPPPHMAPKRSKWTSPPPPEAPSADHTLYENQLGIGLELATASTEAREKEEGYNSSSSNSEILDDEERSDIAESDDVRSVRSYTEGASVTSLSAGPPFRRPSWLSQGGPMRLAQAQVDFSNDPPSRFIPGPRFNRFAVDSSAPSSFKGYPKAGTSTKRSPSGPSRSLKGQSPLAISIPLPPSPESSMTEFSEPATVFYQTAHTKSPHSRSTFVYPNGTHSPVSPYHPHHPQHQYYTGTIHAPHDIFPSNLPPMFTSTSSSTSTSQEDNGLSQVVDYPNANGSGRVSGGFNTPTPTTFPPTKSFHSHSHSAATIVPAVPSPDHDASRFSENYVIDSSAHVTKPRSRSRSRSYSRSRSPHLHSALSLPARNPSPPIPISSSTGQTGASATSNSNDSSPTPSSTGYATSISRSPSPRPLSPLPPPIATQPESMKGLDTLGTLGTRRTTPPDIVDVELERVALLQSPSSEVPIEVGIGNVSLGGESGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FYS9</accession>
    <name>A0A8H5FYS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000062">
        <property type="protein sequence ID" value="KAF5353727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FYS9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5353727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="190" mass="21947" checksum="F5A8CF0CFA9123AF" modified="2022-01-19" version="1">MGGRMIVRPDYRVKVLYSWDGNMKYPSTEGLPLVAESEFWLYCPRNYRPSAQAVITELDWISNSGNDWMPTIRWGKRTYANITKRQEKVLKVAKEIDEMLNEWYGSESSSVEGGDVEDEDKVKDKGEPDDQFEPHTYAEHSPMDTPGPGPKLPLFSYPKPSVTIFLFPFRRRRQKFRDSDAGDRRVSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G1A2</accession>
    <name>A0A8H5G1A2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_009490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G1A2"/>
    <dbReference type="OrthoDB" id="3265210at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="257"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5356448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="872" mass="100844" checksum="25D881105D830AC3" modified="2022-01-19" version="1">MNTANSSHKPHPRLKKPVVFIQKVPATVLKEDIFKLFRKFRVSDDATITLTKASTRKATEAGEQVACVEFSSLDSAEKAMALLQHEQLTKFADCISFALSQKGFPIKPSSGPLPRLFKYQELNASRIYDVLRPYGPIFSMKVEEKYGTVSVVFWRVEDADEAVRFLDQSKRVDEVEAKLWSANSSFQSSETFSTVRFLNDSCAFNSELNTLKSQVEMDPPSEHKSGSVPILPESNDATTIPVTESSIPVPSTPVTGCNLFCSFLPVLMDVASFRKLFSKFGDITSAEIPSRGRKRGYPHGLISFKNRQDGLRAIDAMNGLLLEGRKIVVRLDRKDSKINGNGNNGSSDHTSTEQPTPMEHVHPSVDTEWHGVSEGRTSSLPQTMDIDADSSVPEPEIEATSFNPSDSETTLAEGTSPVPSYSKDAQADILETDFHNLASLMCNIWKEEAGKLRVEVVDLRVREGRIAEELKAQESRIAKELNDSRARERRIAEELENEKVKHEEESREAQEEIASMQMKINGLEWGNEYLDKEKSRLQRQLDLKFEEKAEAEAMAKEMSRLREELTKCEDRELGLMERAENLVERLQEAKEREAEKENTIVQLERLFDLSENKIAELERQLELSESRRKILELEADKPKWEEARRKRERAKKEEEERTRQRSVEEAKQRMEAIRQKEKEARRLKKQKEEEEQRKEEERRKREEAERKRKEAQRRRELKEKLQKENAWREATAKEVERCRTRDRKWTRPWSTDFALIRFKAVMEEFESQKFSTSCPMVLLAIPWPVLLNPSILKLDHIQWDAVEKFFDAIRELMTFSDYKALVDRAHKMFHPDRWRSRNVLGSVMDVEERDAFEKTGNRVSQAITPIWRNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5T4</accession>
    <name>A0A8H5G5T4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000047">
        <property type="protein sequence ID" value="KAF5358969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5T4"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5358969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="123" mass="13839" checksum="B3125F45FE3A68E8" modified="2022-01-19" version="1">MALARPATKLPPGANRILFVKNLNYQITGEDLYDLFGRYGSIRQIRIGNEQKTKGTAFVVFDDVMDAKNALDHLNGFHLQERYIVVLYHMPAKQDAAAAKADLARREEELAQLKKKHGIGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G895</accession>
    <name>A0A8H5G895_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G895"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034331520" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="5465" checksum="11B89FA112DED262" modified="2022-01-19" version="1">MQFLNFQKSVVTVAAVLIVALMASGQANAGPVPVNNARAEPTGCQCGSLGGCVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GA70</accession>
    <name>A0A8H5GA70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron permease FTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_009048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GA70"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5361188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43035" checksum="0276A1A7EBDD6B9E" modified="2022-01-19" version="1">MGKNLFSVPIFFIVFRETLEAAIIVSVLLGLAEQIVQEDPDRISGINRTPAVVVEDSNDKGESGSDSSPTPPDAVFEDDEVQRKRLIRKLRIQIFSGAAIGFLIALAIGAAFIAVWFTQASNLWAKSEELWEGIFELIAALMIFVMGITMLKMDRAKAKWRLKLQRAFRNSTVRDGEAQSGKWALFILPLITVLREGMEAVVFVGGVSLGQPATSIPIAAIVGLICGLIIGFIIYEFASRTTLTIFLIAMTNLLLLIGAGLFSRSVGAFQEHAWNNLLGADVDDAGGDGPGSYRVQGNVWHLDCCNPEDNLDNEGWSVFNALFGWTNNATLGTVLSYVFYWLAVIVVLIFMKFNEGRSKFFGVESAAGTRRRVRREKQAEQTNEINSASVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAN3</accession>
    <name>A0A8H5GAN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAN3"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5361423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="221" mass="23967" checksum="037A818174E73447" modified="2022-01-19" version="1">MADNSNTFPMAHFQTKLESNQVPWGQYLIDICRSPRPLGTVIFEEIEEKARENFNLKDYPGVFDFAGAQPTPAPSPQPCLAHAIPHQSCSLPSVFKDHFVQMELAPARGAGKLGVPFVRSTASSRSLGSVAKANEEFAQLSPSDDKKKGTLWNLGLLVDKSVPVSPSIISSCSDTASMTTKPKPMARVLAPRFFQSTGLSTSLLLSPSFPEPNQQVTPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAU7</accession>
    <name>A0A8H5GAU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAU7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044752795" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="80" mass="7765" checksum="A5677E83431F69B2" modified="2022-01-19" version="1">MKSFTLALVAFALAASAQTTVFNGAISLGNSLGPMTTATSRTTTGTTSTGSTTSPTTTTTTTATTGTTSTDTTTSATSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDG1</accession>
    <name>A0A8H5GDG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_007070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDG1"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="252"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5362911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="647" mass="70338" checksum="DC91DCD173096529" modified="2022-01-19" version="1">MKNKPQCIGCGAIASRMKGDKCGRCKLLELQTQATVQELNHAQTVQPPALPSQAVPPPPQTRFPPVPTQSLHPTVPYGSQNQNPLLTTQHAAMSQSFMDTMNQAKQCKALVDAASLAVNYSNMLSPVITPNEMLELRESKGNKSGVSIMVYCHPRVGRKEVVELMPEYHPFDAATLMHDVKAHWLECLNLCWQFLAPGKLQLNEVELCWPDYFQLGGTSQFVTIGAVHDSHLHLEGFNMKFLRSPADQASRKKLSGGGKFMQLALNIKIAELSTVHKVEARYGQLLPKELGGSGPSRAKAKCKQINDDADISSSTVAPASRFTGPPMSTFRQSQCAIFGRTAGFKPAVISEIKLSFATDVTNNDSEDGDLFFSSNTIVSTTISSSSIGNGLSKSVFQSINSLPLQLDMSFTDVILARETSAGPDGQPSVASGLSGDAICEDATWLIEPRCTTEVIKSSGMMQQVDKNNLVFKTINVFTHYVYYCTDGVKVLVDLQGTLTAKGYVLFDPMAHTKEGDSCMGDMGDKGLQAVVDQHNEMQCNNICLGLQLPPMMFPFALKQRALPLSQTLPAIIHLVTVKLTVHVPPTLDIELKVAVHVPPTLNIELKLATGEGPEIDKLDDEDEDIEGGIPEKNVNVTKTDNGSGIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDS0</accession>
    <name>A0A8H5GDS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDS0"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034017168" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5362875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="380" mass="40440" checksum="25A170C77C06D548" modified="2022-01-19" version="1">MVFLSSILSTALTAVSLAQLSSAHSHPAPGSPEAIKRAVFQQNARRSLADCQDTLSKRGGVHEQAKARREILANEIRMARGLNTAAPFKRDLDSVLATDHHSNKTGITNNTDASTIFEGNSSCVLASETTQGPYYVDGEYVRYDLREDQEGVDIYVDVQLIDVSTCEPVPNVYIDFWHANATGVYSGVSASGNGNSDDETNLNNTFCRGIQKTDEDGVAQWLSIFPGHYTGRTTHIHVLAYQTNGTLFTNGTYSGDSISHIGQIFFDQDLISEVEAVEPYSTNSQTLTTNDEDGIMSEEAENIDPVLNYVLLGNSVSDGLMMWTSVGIDASAVYTTSAAATLTENGGVANENAMGSGGPGGSGGPPNMTMPSNASAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH68</accession>
    <name>A0A8H5GH68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH68"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="41" mass="4461" checksum="F293C66ECF619908" modified="2022-01-19" version="1">MSEPGGAEKVNLNKIMRQNGYKRISSNGAPTYTTAVFGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHI0</accession>
    <name>A0A8H5GHI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHI0"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5365082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="172" mass="19794" checksum="8DB53D6A066FF9D2" modified="2022-01-19" version="1">MDASASRPASIRRYAEGLTLLQHANIRLREAFSHLGSVAYPTHTQTTGKQNDSVTITIAFYSLQIRHQSAGRLLEEEVARVRLKINRDETPTVLRLAQDIPKFHGKFKVTIFRLPSDCNNDLPRSYMLSVKESNLMNTNASLGIRRTFLLPVCHPKRFFISHYLKWLFFLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHW0</accession>
    <name>A0A8H5GHW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHW0"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1279" mass="138191" checksum="A6606CF5B36FD53B" modified="2022-01-19" version="1">MGEWHRSKRRRLNCFVDIEAEQSGSEDLTDDDGEEETGDGEWDGLYHAYGGRAGGDDDDFINDDSSSSDSDESLDDAGTGRTGNSNTHLAHILTDRSRHLGSPNAAPARNGDDNDDVSSSDSDSSWGSSSHTDSESSQEEPDTLHDIVKMTLAEFEPLWRFRCTAGKERIVAAKLQSYSSHLDHSVHHLTLSFVSYHGLPGWVYVAGQHRSPELCRWIAGLSAYVTHSAHTDLNGSLISESINHHPASFSLTGGISFPSSASPGSSRRPVRDPKLFRRWVRVVGGKHNGEIGYALGMGHVASSVKRVKVLLVPRISLSRLTSSPSASCSSSSPPSSLSPRTVDASNSGAGGSSRKRRRRSLAASFLATAELPPHRLFNPAEIRSAYGQDSMIPVKRCEHGYRFQGDRYQNGLLVERLRAEQLQVIGDDLKEVRPNDNIAAYASTSMPAPALGSNSLTNPATTLNTIPFHLYQLFRRSGHHEIPDEMKYFPRIREWVFDEGDRVAVICRGRVESTSTVSVGDVLRSLANGQVEVDFGVGPGGSSRYIETGTTSQHVKATVYAGHQAIPWWKLAKVFEVGDYVKVVGGVNEGSSGWVVSSNNGRSSGVSSSPSSALSGRGRSRAVGSDIGMGMSQVEVIEKTAPGAVVSPVGDSDGLKSFFVHPNLLKSVPIPAEFSLILNNTSPSTSTFSFSGSGLRSGSVFRPDIFSSYNGATVLIVDPRRPEYGKQATIIDIYRECSVATKRLWVKVAVEITDHGALMRNGLVGMPSQRVELDYFGVVDLRTRKLLHEVYPATGQLHPLRGVTVPWIGVNVTIIQAHSDKGKHAVVRDVVPIAVLGPPPPTTSSHKEGKVDVVEYPSGLRLTVELSGYTAGRTNSRLNLDYYRVATEDKATRGMLKWLHEVYKLTPEQIRAGFRPRSVLEARKYNSRIPEGDIPLPPLVLSYSISELARMMGRTDSTTHTCTDHGPTAGTVSSFPSTPSTASSRSTVSPSSSRSSSTGVSSAASSPSSLSLMSSSSALFPPSSASGLPPFPSVPLPACSRCSSPSIAGAPSSKPSCPYSNAASGDPQSPQCPFSSPNEGNSAIPSATSSGRALSSVASFGASSRASSVSSDSSSISLGSTEPDISGHWILDPRLRGKKIAATAHGGGYINKDVTVIPTTSDDGEAHIVREFYNKRYSIQSRWLYPQHPNGARYNGLMVIIGGEHVGKYVRRYNHTRFNSVYVEVVEHVEGRRDIPTGERLVLEVHDLCMAFETMKDRHLNHEVLKARRDPFYRTHRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI10</accession>
    <name>A0A8H5GI10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000029">
        <property type="protein sequence ID" value="KAF5365110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI10"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="75" mass="8785" checksum="8A16BDEA46529D49" modified="2022-01-19" version="1">MSDFKVELNNWAQLRRHILHYEYSQPQPIRGQNKWTVVVKVNEEEWGKGQAAKRHDAEELAAEQALKVGKWSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIF6</accession>
    <name>A0A8H5GIF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_003167</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIF6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034602031" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="23"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5365656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58098" checksum="2FE2CEB7CE868DA5" modified="2022-01-19" version="1">MDTKYYVLSLLLLASSLFLATTRKKPQYPPGPKPHPLLGHLLQIPSIQSWKYFDRLSKQYGPVLRLHLAGSNMIVLNRPEDAEELLGRRSYNYSSRPPLIYAGKYQSNNKRMVLLPYGETLRQQRVAFHQMLQPRVVGAYESMQEMESVKLLFDILQSPRNNIRHCQRFSASLVFYLSYGKRLDDDGDELAAISDVLQNFVQDTTPGAHLVDTLTFLDYLPDFLAPWRRKAMERHQMELKLYTRLVTEVKEKVEKIDSGFECFAARLWDQRDTLNFDTEDIAYVAGTAFEAGTDTTASTIVWFLMAMLLFPDTMRKAQAEIDAVVGSDGKLMPGFLQIKDLPYCVALTKEVFRWAPAAPGGFPHYTELDDEYKGFKIPAKSMVIPCIWSMHHNEVEFQDPYTFDPERFMGKSDEQFDSFAAGHYGFGFGRRQCPGRHLAGKTIWIGVTRLLWAFTIEPALDHQGNPVKVDPNNCTSGMTSRPNDFPVKIRPRSLVHAETIRKEWARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJH0</accession>
    <name>A0A8H5GJH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5366027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJH0"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="122"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="241"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39841" checksum="073CCC99CCB0E5AB" modified="2022-01-19" version="1">MTSTLPPLVQAVAGAIGSATGNTLTYPLDLATTRLQLQHPPSTSALRKGNKTRGPAGILGGFHVLHSIAQEYGITALYDGLPTDTGATLLSNFLYFYFYSSLRDFFLHARQRRLQSKTLPQLTMIQELFLGFLAGVSSRAISMPLNIITLRLQTERTQKDASDSEDEEVESTEETGVVHVVKQIYKEQGLAGFWSGFSTTLLLSLNPSITLACFQVFRRMLLYTRRTRLQRASGKASVLDPTPGEAFVGGALSNSIAVAILYPLILAKTRLQARKRSLSELPTTANSKTPSVPSLTSVLMDAYLGQYPEGQRGKREGGMKALYQGLETQTLKGFLNQGVTFLIKGRIEQRIVDAYLRRRAAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJQ7</accession>
    <name>A0A8H5GJQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="12" type="ORF">D9758_006678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJQ7"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="11">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="278"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="10">
        <location>
            <begin position="613"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="783"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5365985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118262" checksum="25B54E2746B29C33" modified="2022-01-19" version="1">MASSSSTGPSIPIIFSTQTPYPLPSQKFMLPASWKRYHLSQLVNKALSLAKPVPFDFIIKGGILRTSLAEWCSENGVGEEETLEIEYVESVLPPQKMSDLPHEDWVSSVSCHLPGYFFTASYDGYLRAFDYSQKPVFTGQVHSAPITSMCFVPSSSNASNDGDGETSQLVATSSHDLSAQLSRLTLSSSPSEKSKIQVLASLHLHTGPVSSVASTSSGKHILTSSWDSLIGLWDTSIPSSDEVPEPSITDRERKKRRRLHGGEKDAEKPKRKAPLMVLKSHTARVSRIVIGNEGNDNSAYSCGFDSTVRIWDVENGICSHTITASEKPFLDIALNADGQTALAASTDRTITMYDVRESSRSPSASSGSLLHPATPSGIASGTTAHQVVSGAYDGIVRIWDLRSQKNAMASFKAWEGKKKVLSVDWKRGMVGVGGEGGLEVWKAVEDVRIDQCSQSLASSPLAILANPPGFSHLINRVRIARPPPTLPVKEQFKHILACLVMTSLGGAEGVVIPATHPGLKKIPPYWYPYTTYAKERWLGRELLEVVSTEFRDRSMEYYRYALESGVTTINGKIATPNQIIQNGDRMENVVHRHEPPVSGKPVKILLEDKEREFLVVDKPGSIPVHAAGRYHRNTLAAILTSDFGYEKVYAVNRLDRLTSGLMIIPLSARCARRMAEEFVSGTVRKEYVARCKGEFSETEVVCEEPLLTIDRQMGLNIVHPEGKSATTIFQRIRYDANTDSSVVLCKPLTGRSHQIRVHLQYLGHPIANDPVYSEKRIWGSTMGKGGLDLAPSDERSAPKPPEHLADSNSESLGTPMAPAVAAAEGLDNPSTETQMQTQTPRKLLPRETGEDIGMGSPVPLSSEAVEVITRLRNMKDEAEDWSRWRDVVFRAKGNLRAPRSLEIKRPPPQNRRKKNRGEFVDQSLNDAIKALNVSQSEASSDVPTSNLTSEVNTPLELGAVDIAVAPAEGVDKASGAAAAAVEGPERELEPFQLSTAEAIEIARKVISDAEGQALIPEAPREDGEPQLYCPECYLPLHPDPKPEKLYIFLHALRYTTSLGCFETEMPEWSAEGWTWDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK46</accession>
    <name>A0A8H5GK46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK46"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="72" mass="8052" checksum="5A4579F97A4F3CD8" modified="2022-01-19" version="1">MVYTLEGLIWPSTGTHVVVSDIPLPSFNGVEAQIHQFVLEAVFKATLANEYIFIYRGYASSQSWKTAESLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKJ1</accession>
    <name>A0A8H5GKJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKJ1"/>
    <dbReference type="OrthoDB" id="2851736at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24195" checksum="BD89386964A44246" modified="2022-01-19" version="1">MDSFFALPIFYSVLTDQILTMTQCHVNCFATELLLEIFNKLVEMDCWDQGELCLNLNPGCHPALVLSQICPTWRVISIDIPALWATFEIQVVKEENLSDEGIACMKHFVELFLQRSGEAPLDFVLALPPRTLDEEELPFAFSALDPRKLIPVIRLLYTNTHRWRNVSLVAYESLFLNQDIFPHSRRSSSMPSCIELIPLMKIHIQSFHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKU0</accession>
    <name>A0A8H5GKU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_008956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKU0"/>
    <dbReference type="OrthoDB" id="3262409at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5366595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="315" mass="35418" checksum="D6D928B5A85907BA" modified="2022-01-19" version="1">MTEDSAAPPLTLPPDFVATSGGPLFVTNAINWLFMGILIQQVFNYQKNFPNDMSYIKLLVAVLFALEIVHWIIVTMDTWYYLIEISGHPEGFFIVPWEAAAIVILTGIVSLIVQSFYIVQIWWISRERFVLPIVALIGLISLGQSVMALAGGSRVLKVRTLETVAENRSFFPGSFVADTLIALTMSWILYMNKKWVWFRKTETLLNRLILNTIRTGCLTSIIAGVTLALFDIFPNLTYYGTPANCLQKLYTLSLVANINGRQAFQSHEETEAHSFSDIRFLQQTHVSDGEHPNDTRFPAASEILQGNDLQPPDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL72</accession>
    <name>A0A8H5GL72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_004053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL72"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5367048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="507" mass="55478" checksum="74B0A49C1E930891" modified="2022-01-19" version="1">MPVTRSTKRSSLHLDPNVSRKSPDEEALTPISATTGSPANMSPSSSSPEAFEGDNDGDIAGTCDSTSSGARSREKKKRCRVTPEQLVHLERYFVSDRSPTAARRREISELLGMQERQTQIWFQNRRAKAKMLDGKLTNRQGTDTPPDTPSFANATDVDVYNLLHEDEPITLIPCTDLSIGTWRRIATSLSKHDLIAYVCESKRCLTWFILSGGNGFKMDIPFESIREVSFRSAAAGTGVATFSLSEPPHFHLEQSAPRMDGKMSLSWKQCSDWTEGAQATVVLRHELLGPMAQLSRLVHGLNNIIAPGNVRLQSPSYHTNTVPTMDIPVPPMAGLTPSFPCSSTDSASDMPADPTLSTLSLTPMRPAYSGISRSMPSLSIPLPYDLPSQDSSPASSLLPTPYDDIRTRLHPAYGNDMSILQGPYSAVSTSQMPRFFSEDVSIAQSLQGGSRRHSWNPHSGYLGNMSANFSYQSLSNETLPQFSAGSSLCGPSMKYECDENIHFNAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GL78</accession>
    <name>A0A8H5GL78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly(A)+ RNA export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5366977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GL78"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5366977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36287" checksum="CDA1BD63EEB777B8" modified="2022-01-19" version="1">MSFFGASSTTTNTSTTGEKDIEMPDPPTDSISSMSFSPQADYLAVGSWDNSVRIYEVGAGGQSQGKAMYQHQGPVLSEGNKILSGGADNAGRMFDITTGQTTQVAQHDAPVKVVKWVDAQSGILATGSWDKTLKYWDLRSSTPIASVTLPERCYTFDVQYPLMVVGTAERHVQIYNLSNPTTPYKTIISPLKWQTRVISCFTASPNSGFAVGSIEGRVAIQYVEDKDSSNNFSFKCHRRDTTPNAKDQALKPSGSDGTIHFWDKDARTRLKTFEAAPGPISCTGFNRTGNIFAYAISYDWSKGHSGMTPGHPNKLMLHACKEEEIKKRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLS3</accession>
    <name>A0A8H5GLS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLS3"/>
    <dbReference type="OrthoDB" id="2992919at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="630" mass="69646" checksum="2EA78EC5FC94BE7E" modified="2022-01-19" version="1">MLATHSVPSSPKRVFMSKENRLYPIQDGPAQATANKRLRSNSGNGRYKSVEPDMFVSSAWSEGRENTRSPRPSPKAPLIRSTPHSLWQITPTPKENTDPRVEISPVKKCGSALDPIGSERRQFASNASVLRTANATPDFKPPRLPVDSPNRESFTWAGAGPESNMDLLTSPLSLMSPGQGQEDIVKPMVLVTRPLRPAVGPHRHSFHKAPSFLLSSYSPNSNHHSSNSLPSFSSSYTYPAYLSLPNAGGTIDSESAEYPPMTITQFASVLREIRRKNPHAPKMPSMLNPLRASAPFMYYHGVEPNTRNPYSNLTWNFQKRRVVVNRSRSICAVSNKNLRPVVYVCNGDTHHCIMCKRENLLKRLLISRYWRRQNQAEARARLARLEMELERQRRVIAMGYGQSVPRDVGESESEFESGDESEGEDSEDEGTDGEEFEVEVSDAVVDDIAVADADVDGDVRMEGALGLELGLRNIKSNGNSKSSSKRNITNHARAHMHDVDMDIDDVLDITGARSLVQDLKHYARAFDVGNGVNANAAVDCTRVRDRVEGTDGGEAVESDLHRSFLLSVPGVPDRRGDANGDASFNVKRGMDIQTEMDAGVGDWVPDSPVLKDMDSFPDVDHDGELLCDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GM94</accession>
    <name>A0A8H5GM94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GM94"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="309" mass="34627" checksum="2C78E840E1B99F89" modified="2022-01-19" version="1">MASFLTTLVSETQYPPTIILLHVTRRPKFEFNPAAASFSSFTSPPASPTADYLKSTSTPKPASIPSSSSASELEFDLKWTANSMYSASGDTTITTSLQHFHDDVVTSRGSSLPSLRSYMPVGILCVFTFYSEKMEAKETGKQVEKENNRPPRPRPKPFTKEKGLNRSTMAVHEAGLLKEEITTNQAETRQPQHSAGSKRRCHAEKRSEETEDGKFHRIWNIWAVMRNEELFECPDEFWPETEEEKVILSYNGGDDADQDAKRKAAKETLINQHLGIWVGEETVPWTKSGRRFHVVGVCVFDGFGVSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GMP2</accession>
    <name>A0A8H5GMP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000018">
        <property type="protein sequence ID" value="KAF5367727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GMP2"/>
    <dbReference type="OrthoDB" id="3048815at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="690" mass="77818" checksum="55D0393467131BC9" modified="2022-01-19" version="1">MSNWEEDARDMAPLDCTSGSEGLWKFIVALWTVLFSTTGDPREADFSTDWDPEQRLGLSSLTELVSEPEASPAITTVISTTLPHPDDSDWKSQAVSGWERKALQCIEKIGTFALSAEGDIATLTEELTQDLSITVFPPSWRQAIDAASMDPFEADEDPYAGKRQFEEQHAPGLLKWIDTIKRYLLKHHHTITHHPLKSFQHGFCLPSQWPEYQVVSTWKPELGSYPQQTDIIGFLRGHPAVPIASVVKQHNDAGVSWSWVSMQPLTTVQVRELLSWCPPDIKPSQWIRVTKGPYKGDTAVELQAKRKAESDRPAQRLFCTKDHSDAKELFVEGHERGNIFEYKGEEYHYGLLVTTIPYSSASLVDVDMDNHSRHLFKASNSRYIVSSLPTPRDWQFFVDDRVEGVQSEVLAGIDRDVAKESLLCKGTIKSIDSDACWVQFDDLADFPEEGTVVKIPKLNLLKRFYVGDWVTVEGGPLTGLTGWVLSHFDETLVLYHDKPGTQEGEEFSAHPNECRLTTLRAEGAVPWINAHVHIVAGKVYKGYTGVVLDVSKSWQGFVMLQVDLPSVSITLTNCFQAIPLKPHQLGLWQMTWPAQGTETPEEQERDELPRALNIPQHYPDSVNMPNSTKMIPMLDRHNQQLLTPENSLLLRNHLILGLGRSSEVGILNMRWTTPGYGTKRRDYHFMPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPV7</accession>
    <name>A0A8H5GPV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_002976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPV7"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5368892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="289" mass="32511" checksum="1F0141F9A279FF2D" modified="2022-01-19" version="1">MASSSKPGQSSATTLDVYQELSFIRDQRITLTSSAPFTPSFVIASVSRSSNPAEIYAERVRGRKILLENPIKVSRAKQQLEDQRKKRKEAKKKRAKNKLLMKRRDAKLNGIWKLEKGQAKFELFIPLHHLWMGYMSEILGLPQSSSVSGVPTLKDAPSSVGMHPKLVKADFHGSILTVKQSKCPSLVGLSGIVIHETENTFRIVTRDNKDKILPKQNSIFTFSVPLFSTLPPTYTPDQAFPIPDPNSESVKATVLDMPHLEFDLYGNQFRFRSAERAGKKFKPKETIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GV57</accession>
    <name>A0A8H5GV57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_003598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GV57"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5371622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="363" mass="39598" checksum="8FBCB654D461073D" modified="2022-01-19" version="1">MPCALRTPSREIIPQAVSVRYGLAIGAACAPLVQALMWVLSPVAYPIAKLLDLALGVHETHTYKKRELKSFLGFHVTGKEPLKEQEVRILGGVLELDTKGIGQIMTKIEDVFTLSADAVLDQAVLRAISESGYSRIPVHLSGNPNAFVGSLLVKQLLCLERSQLENMPVSSLPLSILPEARPETSCWQALNYFQTGRAHLLLISHTPGRPGGAIGIVTLEDVIEEILSQEIVDETDVYEDNVSRPRRLVRRGPNRSLMRGTIVEYNQKPPLSSTSTMVASPSTAPSTPTLMWEVDDEDVLGLAGGHLKAKLAQATHVADSESVSLGRETDRDEVESGHGEQTPLLLGKLNDKRMKDYQATDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZB2</accession>
    <name>A0A8H5GZB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type phospholipid transporter</fullName>
            <ecNumber evidence="3">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">D9758_000971</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13 21" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1427"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1458"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1509"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1544"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1590"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1636"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="25">
        <location>
            <begin position="50"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="902"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1273"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1691"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="1158"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="907"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1705"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1735"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="18">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1008"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1076"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF5373828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1815" mass="203992" checksum="681306A4BB631B73" modified="2022-01-19" version="1">MHWATWMAEGQVSGAMTSTIDSTMAEEIRAESYVGFDTITQQIEHKLLKRGFQFNVIVVGQTGMGKSTLINTIFASHLIDTKGRFMSDEPVRQTTEIQAVSHVIVENGVKLRLNIVDTPGYGDQVNNEGCWDPIIKYIKDQHSAYLRKELTAMRDRYIQDTRIHCCLYFINPTGHSLRPIDVIVMKKLSEVVNVVPVIAKADSLTIEEREAFKIKIREELIYHNIRLYPFDTDEYDEEELHLNESIRNIIPFAVVGSETNVLIDGKSVRGRKNRWGVVNVEDPNHCEFVNLRNFLTRTHLQDLIETTAQIHYEAFRSKQLLALKEGVNQRPAGVFLDNDIRTSHAYGVGMNEFAAMPPAKSNRFTPFYTRLAAFNVENLFVRKKEPGPRRTVFINQELPDDYYDHKKRVKRPYVYATNQVITSKYTIITFLPRNLLEQFRRIANIFFLGIAILQFFNKFSTISPGLVILPLLVVLGITAIKDGYEDIKRHQSDRRVNYTTVCVLEGGDFVNQNAMKRKSRTFVRAIVPNRLLHTAKKPNAPDVEKAEANPTQELSSPDPMPQRLPETDLDDDVVDDEGGFFSSAGNDAHQKPHWKRTIWEDVRVGDIVKIVDNESFPADILICATSEDENVAFVETKNLDGETNLKSRTAVSSLTHLRSAAECAKKESRFSVDLDRPDTNMFKLNATVRQEGRLNEDGEKEKEQVPADIGNMLLRGTVLRNTAWVIGVVLFTGEDTKIVLNSGGTPSKRSKVERQMNPQVFLNLILLAMMAVTCAIVDSVLEHRDYPRGAPWLYAANQSDDNPSINGLVTWAFALITFQNIVPISLYISIEAVRTCQALFIYFDTQIFYAKTGQATLARSWNLSDDLGQIEYIFSDKTGTLTQNKMVFRQCSIGAKVYIGDPDEGSPEQSSSSSQVHSTANDHSSSSANSNPSDPSDQPSTKKESFFHSPELTSDLQEALHSSASSPNASHARVLNGFFSVLALCHTVLTNTNKETGKLEYKAQSPDEEALVRAAADVGYVFRGRDREILYLETPTSRERIEAEANDQQEKDDGFTGKPSSKDKYEKYELLNILEFNSARKRMSVVVRKLDGDKNKLFLLTKGADNVIFERLKKDVDEPLKQQTEMHLSEFANQGLRTLTLAYKVVSEEEYENWSERYHEATVTMENREERIDEVSDELEQDLRLLGATAIEDSLQDGVPETIADLKKAGIKVWVATGDKLETAIAIGHSTNLISRESNIIVIRGDSRPVFDQIIGAIEEFFPDSGILDETGVPLPARPSLHRRSISGSSAHEARSRPRPQRRQSGVTSIVGSDNGERPGGFVLVIDGVALGNALSDETNKDLLLRLAMLCEGVICCRVSPLQKALVVLMVKHGLGAMTLAIGDGANDVSMIQAADVGVGIAGEEGLQAVNSSDYAIAQLTSRTSRILNFFYKNIVCIGVLWWFQIYDAWSSAYAFEYTYLIFWNAFWTLCPVIAIGIFDRIVDDHVLMDLPELYRYGREGTWFGMKWFILYMLDGVYQSAIIFFLICYTYQSTPTTRTDGYNQYLFEFSTVCITIFPMNGLLLISATLKTMVFAAVITANLFNGLNTSFWSAWVFFAVFIGIVLVWVYTAIYNIISPGWFVTPVYGNNHILFHSAYFWLCLPLTIVLALAPRYIFKAWKFIWAPDDIDIMRWQVKIDPHNRNYAQDAFANPGLHGLRHPTRQESSVPSSRRNSNDNDSTVSVPPPVAATASASGPQPNQSRISVRSASRVDMSTGLRSVHRGFDFSVEEGGPGIQRIQTGLSERRISRLGLGSLRLKRRSGGIDRALSMFKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZB5</accession>
    <name>A0A8H5GZB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZB5"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="23188" checksum="791158F584D5CD75" modified="2022-01-19" version="1">MFEISERLTIRPFKETDLDHFLDLSNDVRVQPTLTTDYVVPHGPKHKDELKKILETAIFCGIIETREAKSQSQSEPQSESDSTSPKKPDKEWVGITSIHSTVRKNRDGMWGIVLDPKHWNRGYGTEVTTWMVDYAFQWLNMNRVSLSVYEGNPRAIDLYKRVGFIEEGRKRKCNWVNGRWEDIISMGILEDEWRASKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZH2</accession>
    <name>A0A8H5GZH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZH2"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5373817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="447" mass="50722" checksum="005CEF610ABFD744" modified="2022-01-19" version="1">MATTPFPGLRQFHEGRGFKQWTGNDSKGLMKVYLPAIVGHVPPQMVQAVADFLEFCYLVRRNVIDEDTVAAIENAISRFHHSREIFRTTGVRPDGFSPLPRQHSLVHYPLLIQQFGAPNGLCSSITESKHIVAVKRPWRRSSRNQPLGQMLLTNQRQDKLSAYRVDLESRNLLLPRKSAAPPPPPPPPPLRPGTIDEPEEEESGPIDQPYSQGDVKLSRKPARKIPRRVDDLADYLQQPQLWTLLRQFLYNQLHPDAPVGQMGRDIPIDQCPNLDHRHCVFLHHSAHASFFAPSDASGLGGMRHELIRAVKSWRNGPARYDCVFMEGDDEGEVGFEGLLVGRVFAFLRFKHQGVDYPCALIHWFSTVGNAPCDETGMWMVQPDLDRQDNPVMEVVHIDCLYRGAHLIGITGDERVPVHDFGPHNSLDKYMAFYVNKYVDYHAHEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0A4</accession>
    <name>A0A8H5H0A4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0A4"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="1">
        <location>
            <begin position="188"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="38714" checksum="8609BA27F57AD061" modified="2022-01-19" version="1">MFPDKVERLVIDAVVDSEDYYNTAWDTSLRDTSKVLQYFFNACSNAGPSKCAFYAETPSKVEKNLNDLYDSLKRRPLPIKTPRSYGLLDYARLRETIFNSLFSPWASFSRLAEGLAALASDGNGTILFMMQEKEPSKCSCGGDPDPYLFGSFHESPYTAIFCNDGTPIPGTFEDTIQYYEKALKLSEWSSVWAGIRTSCSGWKHTSSMHFRGTQRNFNMFLLNKLVLTGPITGNTADPVTPLSSARKMAKAFPGSVVLQQDSTGHASISAPSTCTQSHVKAYFINGTLPQTDTVCEVIGDPFTHEEKLDELLATPESTSFQTPGHQIAISETRSDEFELLKAVFRQLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1A1</accession>
    <name>A0A8H5H1A1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_000435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1A1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5374789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="30872" checksum="76D8695AE340F477" modified="2022-01-19" version="1">MSKGSSSAAAENIKAFTAGGFGGVCAVLVGHPFDLTKTRLQTAAPGTYTGAIDVVKRALAKDGITGMYRGMVPPLLGVTPIFAVSFWAYDASKRLILTLTPNRKTETLSTPELAAAGFLSAIPTTAVTAPVERAKVLLQVQGQGGSEQKYKGVLDVMRHLYKEGGIRSIFRGAGATVARDGPGSAAYFAAYEVTKKMVTPAGSSPTDLNLSAIIFAGGMAGVAMWAIAIPPDVLKSRIQAAPTGTYSGFMDCARKTIAADGVGALWKGFGPAMARAFPANAATFLGVEASRKLLDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1E1</accession>
    <name>A0A8H5H1E1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1E1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="97"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5374897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="583" mass="63635" checksum="3797E4931892FEF6" modified="2022-01-19" version="1">MTPDSPFLVLLPLLIILVSLLFLFLLFLICILLLRRRRGIVLRDSDGPTDMSREELIESEGGFGQIETRWLESLTDDHSRRAYLRAKDFQLQYLPNSLPSDITLSQFLSIQEKGVSAWSFEPDYETVNYLLVHARTEITFLPDPASASCVQSNLPLPKLNEVYYWEVKMFDLPETTNVAVGLATKPYPTFRLPGWNRYSAAYHSSGDKSHNYPFTSTSFGSPLKEGDVLGIGYRPRSGTVFFTRNGRKMEDAFTGLNRWNLFPTIGADGPCSVHVNLGQAGFVFVEANVKKWGLAPSVGTLAPPPAYGSERGSILLDVGGRVRQDNSPHSTPGASSPVPSSRGSHRTRRPRPSSGEPIVSSPLRTSTPITPPPPITPIAEEPNNSDAGPSNTRYISPTDLPFHTPSNTNLPPSPGPPQDFDVASRSASPSPSSSRPHSPEAGARNPFSTPRHLGRSLTHIATSLSNSGLELNSQVHPPPESPMSPDPPTPNHHDIHLQALPRSDHQRTSSTGSQTVENDRLDASTEALSRRDPPAYSPLDAFTYADGVRLDLPAEVIAAALEGGAIPDSAVGQRNSSRRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1J1</accession>
    <name>A0A8H5H1J1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1J1"/>
    <dbReference type="OrthoDB" id="3261881at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="449" mass="50524" checksum="6D608937B5908A4D" modified="2022-01-19" version="1">MSYATSSGVSSGIRPQAKAPRTKKCSTRFLSASEIARNKTHSETWQHYQGLEQANYNDIPEDLKADVHGVFNIAGRIPLSWVKKGSPIEGFATPGFLKFVRQAHKRNKDLFGEDDSSVDSGGLFIDISLVFAAWESLKEMANSKSKESWSEADYVAHVYTIIRQAGVKRSTRRNQRRVCLPQPIVHDGMDNEARRILGAKIVIPDCVVLIPQSLVKNLSDSKDSAFKRLKKHKIITRSGAPSKHTSFPYQATPFMSLPNAAGFEFASSFSEDKKPSHESMEDAYRQNRMSTASAVRHLHSLHVDAPVFGLTWAHTKVKAHVDWWRRSEDGPDQLVVYSATYSQQNEEKEWNLEDPADLLEVYFLLRNIDSFTIGSFRERVNQGVQRLLGAVVDEGKTFEPWRRSTESVKRPSRAQKENHSTSSNSSPASSPKHSKQKSGAPRRKNRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHN0</accession>
    <name>A0A8H5LHN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHN0"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="1">
        <location>
            <begin position="351"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5357474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61411" checksum="60F55B55BA48ADAB" modified="2022-01-19" version="1">MSNDAILTQILFQIQAIQVSQQTLAAKVDVLYDVYDLLTVVGRCVSRRRSNSDSKLDKCHFHSSVELYNLGGFRIATSLSTSPPGKTLTTETKDKEREKALYPGRVLLTTYPDQHGIQPYILHWFAKDPLVRGPVICSRLPSSIKFRNALGAHSGSYSIYRALAIGMGTLSPSHRPDYSMTAPPVDIPPNESWWTPGKIISFDPWGHLAPQIFANQLRTKEEGGEGLDVRPSIAVTRAHIKLSELDETVRRGGIDVDGKIVMKSRPVKREDGSVNESIDPGVEVAVSKAAVEPVWYLPGVAERFGISETLLRRSLFEETGGMYPELITRPDIKVFLPPIGNFTVYIFGDPALLSSSSPDVHVTLRVHDECNGSDVFGSDICTCKPYLVYAIEECIRTAQGVQADMVKDGKKKGVGVVVYFRKEGRALGEVTKYLVYNLRKRGGDSADRFQALMSDVLHWLGIGVNGRGSAGADGKKRGRVDNMVSMSDMKYDAVVGSGIDVGRRYELPDHLIPPDSRVEIDAKIASGYFSTRKDGKELTPEELRKTVGRGWEEVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIG9</accession>
    <name>A0A8H5LIG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIG9"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5358596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="25786" checksum="97EBA2B94123D1F7" modified="2022-01-19" version="1">MSLPFLEIAGCRAAGSQSFASLSFNAACALLEKWCRGLLSCVGTHPEARATVSPTLTNNLPSYPHCSSPMASTRRRPNTSAPGDGSRTITITGAPPNEQHDDDAGDTPGRDSSSGAVGTLRLHGATKKTRQKVVWSDDVVDNEGCGKKSSKICCIYHKPKAFDESSSEEDSSDSDDSDCEHGHNHNHSHSHSHGHGRSSGDSGGGSGMQNRDGGSGTVHTLEESSDSDVNAYEAQPRPGKGKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LKC3</accession>
    <name>A0A8H5LKC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000043">
        <property type="protein sequence ID" value="KAF5360263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LKC3"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5360263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="72666" checksum="5864FA687FAE2C05" modified="2022-01-19" version="1">MAEKPTRTALVTGAAQGIGRAIALRLAKDGLHVAVNDIASKLDNLNSLSEEIRAMGMKSSVHTADVSKEEEVRAMIEGVVETHGGLDVMIANAGIAICNYFLETTVEEWDRLFSINARGTFLCYKYAGNQMVKQGRGGRIIGASSIYGKSGNCGPGYSAYAGTKFAIRGITQAAAGELGKHRITVNAYAPGLIETPMGASIDKDMMEKYNFKPGQFLETYRTQVPVGHEGKPEDIAGLVSYLVSEEAHFVTGQTPWLRVQHLPTHPHAAQGIGRAIALRLAKDGLHVAVNDIAPKLDNLNSLSEEIRAMGMKSSVHTADISKEEEVRAMIEGVVETHGGLDVMIANAGIAICNYFLETTVEEWDRLFSINARGTFLCYKYAGNQMVKQGRGGRIIGASSIYGKSGNRGPGYSAYAGTKFAIRGITQAAAGELGKHRITVNAYAPGLIESPMTAQVDKDMMEKYNFKPEQFLETYRTQVPVGHEGKPEDIAGLVSYLVSEEAHFVTGQTDKNQFSFDFSFSISRCDTNSEKKCKRAEEGMKVRSGKFRSVVHDCYRLIVFPKRPVKARTGIKIGEEKEVASTSNLKKGGKKKVGKGKGKAKGATETSIPTTKWPVAKLMRGFTFLTYHRELVEEAMAKLNECKEEGTPLEVDAGNYRYRIMIPGTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL91</accession>
    <name>A0A8H5LL91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL91"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="247"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="40608" checksum="B585EBB16E5AF31A" modified="2022-01-19" version="1">MDVRRFQWAVFIQLGIQLDTTLVVVPTYQLYLYFYIYKPCPDTWFPISTSLSLGPGATVTTSGRYAAPSSVSDSSVSASPPPSPTPLLCVDWLHGLDLTDQKHVSFDIDSYLENGEELYNNCQQQPCSHAHPSIPQVCYYFWEEENSIILPSNPAQLHSHFLCHSPVLNLALVNNQNHLQQAITNFVNRPTHESSDKTAKPAPFKGKPAKLNSFLSLFILWAGEQKWLKLDSGKLDPRKCIAEALLMMEGPAAEWATEYARHISGVRADEAGAVFPWEGNWDNFTHALKIQFRVANEQQLAKNKLEALKQGDKTVVEFSQIFKMWAEKTGFSDQDLQYKFRKHLHKDLFKYGARTEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPG1</accession>
    <name>A0A8H5LPG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_009349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPG1"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="46544" checksum="D52828783A836E65" modified="2022-01-19" version="1">MPRRIVRVLLLLIVVGGIGWYLPRSGPISVNLNVNVPLPVTVHVDNPSALPSYRQHESQHEVQEVQGLVPASSPPQKTLSSKQLSILSSITAFARYLDNALDKIAIREEKFNLLPKHQKPLAEAVGYASHFEDARTRARFNAKFLGNVADYARETYGFGPEDETNKAHWDYVFDFFGHILRDWSEEGKHERDTVFPPILKALKDGMAVIKGEKRVLVPGFGLGRLAHEIANDKDYKVDACELDYGSVIAYNYLVNQTITPFEHTLYPYLTNWQYQGTAKGRFDAVRFPDVLPTSPVHLIEGDFLTEFPESEQYDAIVTLFFIDVSENIIDFLSNIHRLLKPGGLWINLGPLKWGSFSQMQLSAEEVLDLAERLGFTVDHDSRRSIDAVYGHQVGSLLKFTYVTQFWTAHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LPL5</accession>
    <name>A0A8H5LPL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000031">
        <property type="protein sequence ID" value="KAF5364809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LPL5"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5364809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="378" mass="42454" checksum="6D9BBE18F53011F0" modified="2022-01-19" version="1">MFSFLFLTLDHFTKHDEANSVFLSSPTTTTSTSSPAAHPFDTMYGSRKDSSEYVPLATHQDGGSSEDVDSPVGSPTLVPRPKARLPQYLLWTSVLVALLSLVNLVLLPKTILHYELSEAALAKLPYPDLHIGFSRIEKLLHDTLPRPYIHSWPTHIARINEGLKNTVYGNSLEVFVSVRVSFLILSVISPFLIIISIAIKDSTLMRFTVPEGSADQSCAVGWKGPVETRVQDLTTKGDISEIEIWSIIHDSAFDLDFDAVSWGTRPVRGELLGTLDLKSSLANATTEKFRCPSQDKFLVVEFRCVRVDCQVSFSQIKDVHPNMGNFDSRSDFEYRADWMLHNRIRVAQAGALIGQMFWVLVQVLRLNKYIIYVYIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ73</accession>
    <name>A0A8H5LQ73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ73"/>
    <dbReference type="OrthoDB" id="2755229at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="439" mass="48602" checksum="13409DEFE879C08F" modified="2022-01-19" version="1">MDQDDTQTPTRPRTRRPPSPIHLVHIDHESGNLILPNAYDSHGLPFEAEKNRLKWFTRRGPDPGCSFPNPEYTDTIFPFRGFPLSQLFDNVVPRQVAAIKNAPDRHLAVVPFDAGPAFIKDHPTFPHDVEAFMKSFRYEGLENITCVWAEAESKPPGYNKLYGKPWALIVYNPTGFPEDFHREVLYQGTYAFSETFAFSVMEFDPGYLFSPILCNFTGPSGADSLIRNDAQQINTALGTIKDVLRNTNAFFNLVHRLVGQGEESTPVAVYQNTVNWMNTLTLQYVETRNPHVPGTAVYQLTGLPIAQTPEDHALMCNIIRAASYPMAGGLLELKPKHGRLTCAHCKINTHPAHACPSPIYLAGEDHAMRNSIRTHPPMRRLEPQPTTEAAALVDTAVGLAVGPVVEVAVADTGDMSTLVVDVPITRPSSATESLLLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ80</accession>
    <name>A0A8H5LQ80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_010875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ80"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="88"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="623"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="666"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="752"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="838"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="881"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5365439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="973" mass="105990" checksum="25A00EAF9DE14B23" modified="2022-01-19" version="1">MQHHMVAAKDDNNPSNNSESLQAGVGLFHQAHDFTIENSNIEVVGGNQYQCNNINHYHGLQYDIISKLNPTIKAFHDVGARSVCIEGTRTEILENVIKWANEPSPDIPGGYWMCGMAGTGKSTIAKSLCLKLGEEGLLAGTFFCSRQIQECKEYHNVIPTIAYQLAQYSSEFAAVIREALNMDPDIAHKEPDKQIKQLFANLWKDIPPFYTPVVIIDALDECENISLVLKHLIPAIKNQEIPGLKFFLTSRPEQHVKDYFNIDNMQQDRQTLQHFYLHNVQKSIVRDDISIFLQQGLSQMSISKDNMERLLERSGVLFIYAATIIKYITGGGRRAQARLANILDLKRTPDKVETQLLDDLYGQILEEVLSLSKLSHPEQKQSLNVIYTVITTATPVSCQIISELLKLDLGSVQATPLRGHTSLVTSVAVSFDGTRIASGSDDMTVRIWDAISGQAIGQPFQGHEDEIASVAFSPNGTRLVSGSHDKTVRIWDILTGDTIGMPFKLYKQVRSVSFSPDGARIAAGSGDVTMFDAKNGDVLWQIKDGGYALNFSPDGTRIVSASTTVRIWDANTGAAIGQPYQGHQDYINSVVFSPDGSKIISGSDDHTVRIWDSSVQSVIHEPGQGHQGEVYCVAFSPDGARIVSGSDDKTIKIWDTSTGNAIGQPLLGHTHYVNSVAFSPDGTRIVSGSYDKTVRIWDANTGDAIGQPLLGHINWVRSVAFSPDGARIVSGSYDKTVRIWDANTGDAIGQPLLGHTDGVNSVAFSPDGTRIVSGSYDETVGIWDANTGDAIGQPLLGHKYNVSSVAFSPDGTRIVSGSDDGTVRIWNANTGNAIGQPLLGHTHWVKSVAFSPDGARTVSGSDDWTVRIWDANTGNTIGQPLLGHANRVNSVVFSPDGTRIASGSSDHTVRIWDATTLTQPEISHEPCTNSASEVTQFPYVNHLKAGSDFLELNMGSFGSDLNTASPYVHFIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQQ4</accession>
    <name>A0A8H5LQQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000025">
        <property type="protein sequence ID" value="KAF5365964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQQ4"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="717" mass="82073" checksum="5052298014FC3E02" modified="2022-01-19" version="1">MRLLDTNTFEIQEFYTDIPPYAILSHTWEKDEVTFQDMQNLWFATRKQRDQRTPQDTFIIHAVTRKAGYKKVWKACEHARKYDFRWIWIDSCCINKESSAELSEAINSMYQHYEDSEVCYVYLCDVSSTPGPHPRDPVSTFRNSRWFKRGWTLQELIAPSFVVFLDVEWNKIGTRWELQDVVSAITSIPVRAFTHGDVEEYSVAQKMSWAAFRQTTRPEDLAYCLMGIFGVSMPPIYGEGAAKAFLRLQQEIIKISDDRSIFAWIASEGESAPRGLLARCPFEFRASGEVRKSETGHIGDESSYSFGNNGLRIALPLESPASEDSTFLASLLCRSDRKPDVNQYFSVYLQKVAGQGYVRCRPEDLELVPLSSSASVQRLVVREAPISRKRKDKHYDEIHATVPAFFNCTMNNAGQVSSQTSTLRVWPRESVKFTFRNPPWPPIPFAFLNYHSQRFGESFFIALDRLTRCLVVTETRLDTMDDVSRLFAHDEGDGVRRFTKKGAHLLHWSSSPACFDTVVAPLKSGALVSCTFQMTGNTTERILEVVYIPSNPCNIFMTRLLDTPNCGFMVPFKVGDWTLQQIYPPDFFSKECGGQTYISMPNTGDLASTFRVIIYKAKEPLPPVYVTVGFANRFEWIDAGFFELSKETGEEIWRSYLGSGSRRLKKSRHGGSWPCMTMYDLDDWRFRDTQVIASIRYPNTILQLGSFILHIDFGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQW6</accession>
    <name>A0A8H5LQW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_005741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQW6"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61866" checksum="6E7D729099D76075" modified="2022-01-19" version="1">MPIDSDFDFETLQLRTWSSLSKADTDRLLSSITSLQHQVDSYGAEIWGTSICTLEQKQFEVAVTSLQRKCSLLAPIRRLPVEILEIIFALYCSEKDATCVDKPRSGLHVPFIPLIQTCAFWRHVAPHAWPNIKIILDPYRTVDLDLLSRHLHILQSTPLTVSLYSLSYFKSNLRASELDNARRAFDMLLGCAEQWRSVELMGPGIFAWFRVQELPLGNLESLTIRTWTSTFYLPEIRRQFSTLFKLASNLRQLKVDTGSVPIVELGLPFSGITSLSSRACVPLDLDVLSSNLCSNLQKLELRVDNFTSTGAFPVEFIHSDISELHITNFSRPEDFNLFHHFHLPRLVTIHLKGLWVLGTNAWTRLDPLSSMIHRSRPPLRQLHLQEMIPDQNELIALLQAAPSIAHLTVSILEGSIVSEDGLIRHLTLDSPTDPPLLPSLSALELSLCQMDSKPVDEHILLERIRDVLDTWHLSSFSLKLNDGSVLSASDVKERCVVTPLERETISKDVLAQSPIGYTCQSWTQQRTTQTPLSIFRSLIVKVIQPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRK7</accession>
    <name>A0A8H5LRK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_003674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRK7"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000312">
        <property type="entry name" value="Protein phosphatases pp1 regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="9">
        <location>
            <begin position="392"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="8">
        <location>
            <begin position="729"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="10">
        <location>
            <begin position="893"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5367430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129112" checksum="C53DED8BB23253E8" modified="2022-01-19" version="1">MSGEVNKLESTITKVGERTRVAVSHTPADEHHVSSDEEDVKEEEYEVEEGDFLADWPDETEELELVHARIGSLDELRLPRFAKHLTKLFFHLLTKLEELDLYDNKVKDPASALDKLENLSVLDLSFNLLRTVPDSLQYLRSLHTVYFVQNRISKITNLDNLASLRSLELGGNRIRKIENLGSLANLEELWLGKNKITKLENLSQLKRLKTLSLQSNRITVIECLDELADLEELYLSHNGVKRLEGLQNNIHLHTLDVGNNFIPAIENISHLTELEELWMNGNQIPDLRALESQLAHISTLQTVYLEANPCQTNDMANYRRKIMLALKQVKQIDATFVKSVDTFLQTFMSSWISSQYASISKHVTLSDLSQASTSANEETPVLKCTSEARSKDYDNVCLPLTTDAWKKRWTNMCLVPSSGGEDRRRTESRRESRYVSRDFTTEQKAERWRENPVFEADEVTMTRLDEAEGVTAIISGWLELDTDDDWIRLDAEIALHQELNYASYLNIQNAILPAPRNRQRAACYARVVDACLQSLPFMNLSIRLPVYDSSLVHDPLSASSNDAAPPMKRSASLHSVSSRPPTPRLVVSQTIEANPVPKNLEQKIDAAWETWDLIRSLCDYNPRLSLALDLTPPLPNNLTALGKWSAEAVRHIFLPASTFIANTKGYPVLPKSTQTFIRDSMAHRPSFILSGVSSGVHTRGNEVAYSQYIRHLERTSPLVQAVEKSGTVENFAQGYQDYLQAPLQPLMDNLQSITYQTFEQDPVKYKHYEEAIYRALLEWQEDGRIVICVAGAGRGPLIARCITAIERSNREAFVYGVEKNPNAFVTLQERQRSEWKDKVKLFFGDMRVVELPEQVDILVSELLGSFGDNELSPECLDGAMRLLKPDGISIPSSYTAHLAPLSSSKLYNEARSTKDDKNMETPCVVMFQAVNLLSGDGGGPSGQCGPQVQECWEFEHPRKDPILNSQSLPLTNSHNARFAKLRFHIPHAGALHGLAGYFEAVLYRNIGLSIHPQRKDQISKDMLSWFPLFFPFKEPLYLPSNSELQVTIWRLTNQRRVWYEWHAESFLYGSCLDPVSSYPLSATPTIPVTDSGVSLRVSSPLIDAVELAPERRGSIASVVSLPVAGLVKIGHTSLHNAGGRSSWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRL6</accession>
    <name>A0A8H5LRL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRL6"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5367460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="73589" checksum="B06D0AFC4F241D2A" modified="2022-01-19" version="1">MSSNVLMTTVPVFSGADFNIWANILLSWLQATGLSSVLGSDRPSDATANWDEKNDKAIGSIKLRLSPAIRQKTLGMTSAKEIWTTLKNTYGKPGVSAVYTDFKHATSITIPNDTNPSATIELIRMHFDRVSAAGISTDTTDSTTPTASITKIPNFLIVMFIISKLPPRYEYIINQYTQLSISQIDNQDLDELQSEIVNVWESRQGALKGKPQANRLSAVKLKDGNPSFQQQQQQRPSGSSSSANGDNKGKGKGKGKGKAHFRRGGRAGKNKQAKRQGQAHLVHGDMSPMMHTVTFVNTPAAVDSRTKRAINLARNIGTRPSGETVAALEDVVMSNPDLSSFTPLTPAPRPKRTLTERIYWNNLQSSSDGWRCNDNWNDAFTRSVGTQTDSDADMGCAQEEDANWNEDTLVNTSELRSVFGSTTTESGVKVPQDTRTPVPLIDCLASDPAAEIMECRIHLGERFQNPEDPLHIYGEGATPFRAVVNACASTGTLSLVQRLAAVHSEMQSGSLPAHPSGMTTQSLPSSHVASPTPGTTSTGWEWLTPHLENEDGRYDELLDWQRDATVRLGGMEMEEELPSRVPTPSSMPELRSMSPSLSSTSDLEYMSTPRSLSRMSHSTDPGEATSSASIATIGAWSDRIPSPRPSTPAMVIGSATNNYGWSLDSEVSGMDNSYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRQ3</accession>
    <name>A0A8H5LRQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRQ3"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034757546" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="141"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="503" mass="55945" checksum="57D1931EF06FF87E" modified="2022-01-19" version="1">MPSISLKLLPFTLLLAGTLASTLVATHGDFEDAFQDSLGQCEQNATTTTPPSCLIREVEFSTSPQLFADTNQVCSGFPPLTFNITLDDANDDDSEPEGDDQCAREPAFDFSQWILAQNLNASSSSHPSQSVSGSSIVGGLYQIGKKIGQGSFGVVFEGSMLLSDIPVAIKFERNLESPKLVEEFNSYMALNGTLGVPQVYYFGQEGLHNVLVMDLLGPSLEDVFKMCGRKFSVKTVCMLAKQLLTRVEAVHEKSLLNRDIKPDNFLIGVQGADNVNTAYMIDFGLAKYYRDPETQVHIPYKEGKGHAGTARYMSINNHLGRTQSRRDDLETLGYVFMYFLRGRLPWQALRATTDKERYKKIRKMKQSTPIAKLFKGFPEEFSTYMNYVRHLGFEETPNYDYLRDLFTRVLQDLDEEEDGVYDWMLLNNGQGWEAGIIPSTKPKTLVPAHAIVNAVTLHASREHRPDSEDANNSSPLVLNPAPAHAKGSLNLPISPAAKWVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVA7</accession>
    <name>A0A8H5LVA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVA7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="144" mass="16098" checksum="5A7A01E688E8CFD8" modified="2022-01-19" version="1">MPPKPAPKIYQILLRTHKLTIFFTLSPSATVASLKEEALGALTSDVNQVEDVPQVHAVDKFEICRRDKAGRYELLDEGKELKESKISNWEVLYIQFKDESGNLAPITVTEPSIDDDEDVQSMAPPPSDLGESDVRKGKRKAMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LW36</accession>
    <name>A0A8H5LW36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LW36"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="302" mass="33470" checksum="EE64D0B722ED13B0" modified="2022-01-19" version="1">MIMLAAELSLSPSSDSLFAVSTPESLVSRVQNTHSQICTSQTESARLQHSNSYPQRPQFKLAQAPDLRAMYGHIVKDLRDDIFKIVDDWTVDTSTPEGIQKAIEELQFPFNADFLYMHFATSSLFLPAILPILPAASQEMLLRGYFAVIISWWIVNGRPNLAISSFFSADTAHPAITSTNTVQVHAHALPSPSSPLASNPNPWISIVSQSLVHPDDHLIKLVRALAHFATFYGSRAAGEKDFLDTGLEGAGGTDGTLFIRAAGLTMDRILGQMPSRENLKEYVMYWDREGFHTWSEKGKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LWS7</accession>
    <name>A0A8H5LWS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LWS7"/>
    <dbReference type="OrthoDB" id="3259294at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="202"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="755" mass="85890" checksum="5CBAA94392EC1BB2" modified="2022-01-19" version="1">MLTFFKPWRTGKDLKEKKETWDSAFLDYQFSAQQKFLMDNFELRFECLDSRDDYHAQRKAQSLGIDPSKLEPDFDDGIHFGPFKCSDDSLGVRERRRQLDMQEMTDLLANTGWTNAKCDLKSHIPASFDYPSMSPAAWRLEIAKMKSNVITNKLKENKDQQYNFPNKYPDQVEVLDQHMLEEKLRSNQTQKLIDDLCLEFSLNLEQERAFRIVANHAVSSISDQLKMYIGGMAGTGKSQVLKTLREFFKRRLQSQRMIVVAPTGTAAALLQGSTYHSVFGINSSEEGEFWKMSASQICSRLSGVDYVFLDEVSMLSCKDMYKISAKIASALNRPLLPFGGMNMIFAGDFAQLPPAMGGENVSLYSHTIGTSSSDQHASIGKYLWHQINTVVLLRKNCRQTGSSIRDVKFRQALENMRYKQCTAEDITLLRSLISDPSNESRSIDNPRFRNTSIILTYNKHKDVANELGTKRFAAETGQMLADFFSEDEEVVFDELPSKTHDRKRKRRKATKHKINDEVQQQLWKQSPSTNNMQIPATLSLCKGLPVMIRFNGATELCITKGQEGTVHGWQAGKGRHGQLVLKVLYVKLEKPSTDVQFKDLPLNVVPITPNTRRINCKLPDDRIIQISRTQVEVLPNFAMTDFASQGKTRDPNVVDIYNSRDFRAIYTALSRSSSADGTIILQGFNVNHITGGVKDKGGYRQELRELEILNDITKLRENRKLPPSIIGDLRGSLIQQYRSHFGKSHTPDELHESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYM9</accession>
    <name>A0A8H5LYM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_004646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYM9"/>
    <dbReference type="OrthoDB" id="3265539at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5374211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="166" mass="18974" checksum="6E9582F7D6FBD3B4" modified="2022-01-19" version="1">MHSKDPLIIWEDLKAVHCTREFATLLSLKHKFLTMKKKKGQKMSAWIGEVKIQVFEMEEAGLTVPDLDIILTLTMGLPSSYDSLIINFDDTPSSDLTLNHVMTWLLAKEICQLTHTIPTPQMTTTKNVKDLLHNVTLSVNKTSLPVEQITCWFCDEKGHYKENCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LYU7</accession>
    <name>A0A8H5LYU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LYU7"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5375050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1083" mass="118025" checksum="EEDDA0C9FA3651C3" modified="2022-01-19" version="1">MASAEPDASSTSSSTPESSKPQDTSASEEKVATHAQSDSDDKQPVSSLSSSPRPLRIYTSSQLVALSKSPLVCLPNGMPELKDWFGIENEQNLSKKESEPTTPSAGRERRFRRDADDGEPPSRPSFRSSLSQPSQMGNFKHQSLRSTDRDGDKDRDREGQERLRNLSDKYDRDRLGLPLGGLRSKERDVAPHLAGSSRLPNQAQGIAARRAETREANKKKAGETGSEDWRRDSRRSERTENGRPDRDDRERPRSRVRESSRHRRDPSTSRREDGRRERDREREEYRKERDRDEQRRERERDNGEDDDSRRWRDDGRREERVVARRERERNRDKPPHDGPSDGDRRWTVVEDRDTRTKRGVGKDKKLGVDEGKVEERRGDRDKEKEPAWMDTYIPAAGSAGILGGKGNDGELDGIQAWKKSVKEKEQKANKAAPTPANEPPTSTDASQKSAEEPLDEIQRFKKLMELAQKQSPSNGTESLSASGPIEIGPVLKTQESKMDSAIVNSKVESTLPAADPSRSLLSLLNPSEPVRPAQTSSANLDSASKPSPKPIDTELLAPQPSEPGSAQFNPPQGPRLLALGRGPGKPSPLNSQSLVTPSPNGPLTATSPQTLNPRSASSGFSPFEEHPNDTARRVSGERSPFPPDSASWPDSPALDSVGAGQGPGRGSRFAKFFDSKGKDTPASVPNVPKSATPTGLVSSSPIPGSRVEGNFGIASAGHGHEHRTVDDLFAKLSMSSSLSSQRSTQVPNSAPMSNVSYGQQAQNHLQVLQQQIHSQNHLVANNRSEPLYDSRNFMPDGLVPGLRSAPPPRRADGGPGMYSDPLDDALMLNAQQQRLALQQQRGVDQLYSAGLPAGLAQHQSGRNIAIPIQQQPFRGGPSPSNPQASLHNVQQQRLPPGLANLGGRPPHDPSQQYLAMQGMNSQGLHGLHVNGPPQQFNNFGPGGNLGFNGPHGQIRGGGGSTAHQLNSLAQQQQLGNLAHAGNLDVRGGNQAQFLALNGLGSGGLRNAGGGGFNPQQNNTAQLQNQLLGMRPQQQQQQQLPPHMMQHLGPMHLQQQGPSIPNHQPNTTQDLMALLLGGSNHHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5AQP7</accession>
    <name>A0A8H5AQP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000661">
        <property type="protein sequence ID" value="KAF5309273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5AQP7"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF20">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="467"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5309273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="559" mass="61704" checksum="EE38C706A31E8D0B" modified="2022-01-19" version="1">MALPDPSTTTPTKPTIVGIYGVPGCGKSFLLHQLKTDLGEDHFASYDGSAVLSSLIHGGLDAFKKLDDQEKNIFRERAISKIAQDCSSSGRIGIVAGHYLFWDVDVDSGAGKPQVIWTDGDADVYTHILYFEVPADVVVQRRRHDTMRKRPSLSQEHITRWQRTEIDQLREICSKQGIHFSIIPPTSNVLEFTTFFLREQSNFLRAKNQLDTSLRDLSGQRSKTILVLDGDKTLTSDDTGAIFVKLMLDDGLVAEDPLKAVFSSLNYTYTAFWQVARRVYDCDALPEQTFEAYCQQVTASVSIHPEILCMLRQAKERGVTAIVLTCGLQRIWEKILEGAGLSPSTVKVIGNGRSEDVIVTGEVKGVLVSRLRDVHQMYVCAFGDSILDLPMLKGADKAIVVVGDKRKRSVGIDQPLLHAIDNEHLNACQVLLPPTSPPRLDIVKLPLTDITSPHFITSIVSPAELADKNAAKLLMTPMRDATVYGPALRKAHSEVGRHLAVNLLSKYIGLEEYAIQHVQGTQTVGYRFQDEAKMLIVALMRGGEPMALGVSEAMPLAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B6X5</accession>
    <name>A0A8H5B6X5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000470">
        <property type="protein sequence ID" value="KAF5317643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B6X5"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5317643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="720" mass="81070" checksum="84E8B7ABFF284C05" modified="2022-01-19" version="1">MVCYLHRQRQEFTAIQLGFSRNFKTSGASYLRSIALWTFLQSEDFSEIEGVNCPAGYGLRDLTLVFTGMIYGTVSFADPHDEKSWIFYTVCYLPQPRKQFTAIQPGFSRQFQDFWRLLSYSLREPWLGQDSTQAWSCVLSQLDRVLDFLQSEDFGEIEGVNCVHSFGYGLRDWTLVFTVSYMERLALLTPTTKSRVYSIRSSELNASLISPHILRSYHHISDPALYTYVGWVLSDSSAAVRLAAIKVLQIVYENADAKGYHCVDVGVRVTIMSVLGSVDGLVCSLKRILDCFGTMIYAKEPRIQTDVARFVSGAWEEFAASNPDRWRCRAYAQILRSCLKFGLDWWQRLLLFLSRGSWELLEAMFSGSYLYQVIGDLKYADRVERMSYNASPAMMTADMWGRQYLQQQNQVAAKNMTPNLFPEDGPYSNGFGLEPNYPCCTVNFPQGWPKFITNAFLKTADGKSLVHLYLGPFSTEVTLSDGNDVKVVVETLYPFGDTLTTTITATKDFDYFVRIPSWVSGGSISVGDGPKEELTPDEQTGLQKVEVKKGVTVLRLRLPAKTYVSFTEKRLHGSIAVHRGPLNYAFDMGRAEQVIKTDPRETHAIDLQYDPAEAWEYAIDPSSLVYHHDTPASGILPSPIFDSGLPPTRITASACLIDWPLAGDTFASSPLENPECVGPRRVIMLWPFGAIKLRISEFPVVSFREGVIEDVAASQVPLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BVB3</accession>
    <name>A0A8H5BVB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000342">
        <property type="protein sequence ID" value="KAF5329904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BVB3"/>
    <dbReference type="OrthoDB" id="2905268at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034111556" evidence="2">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5329904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="201" mass="21987" checksum="4FF363A3572CF9A7" modified="2022-01-19" version="1">MFPASFILSCFLIAMLSQPTVTFWTKISFHLALSFWSISIAFNVIVTFLIAARLLLMRQRSSKLLGYHSSSPYTTVSAMLIESAFIYSSTGLAFLISYGVNSPVQNLFLPLLGQVQSIAPLLIILRVAEGKGWSKDTANAITHTSSLHCASRGTVPAHITSETVLNTMGSRDRMTDNRGPEEQSIFSEFVGASCEQVAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BXM7</accession>
    <name>A0A8H5BXM7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000326">
        <property type="protein sequence ID" value="KAF5331444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BXM7"/>
    <dbReference type="OrthoDB" id="3251775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5331444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="250" mass="27786" checksum="7D7B6DDD3064CA35" modified="2022-01-19" version="1">MSLIESLFNLELVDSVLSARYLSAVALVSVVYDHFLTLDQEFSNIWGSGSSQGYLHKFTFALNRYVAEAVTAYTAFGAIFSEYWTILRTSTQTLPSASNTNFNIIDAEHLFGYLQLQQQFSSGSPNRKRMTFILFSGFSVSISTATVLAILTVIKAQPVTFFFPVINTCGFLKIPSTLPYVLGILLLFDSFLIAIAVLNAFEATHHTHAEVFKSLHRDGARLFLVLFVLRLVTLLMSIIGNPADTFAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C395</accession>
    <name>A0A8H5C395_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000265">
        <property type="protein sequence ID" value="KAF5334206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C395"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5334206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="126" mass="13545" checksum="648FE3DB81FE805A" modified="2022-01-19" version="1">MLNPIDVGIEATEYGTPDSPRIPIQFCPFNTFLLRGAQFALQNIPVHVNTILPGFFQSQMTDKLSPDQIDQWSSLPAPGTLNPGPSLQPGRQLEIGTAAAFLSSVVGEFVNAINLVVDGEITLVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C7Y3</accession>
    <name>A0A8H5C7Y3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000230">
        <property type="protein sequence ID" value="KAF5336226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C7Y3"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5336226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37485" checksum="127C1A6CA5D6FF22" modified="2022-01-19" version="1">MSSPSSSFYADAVLFDMDGTLTDSIQAVEAAWGKVAKDIGQDPAYVIAATHGKRAVDNLAQFKPHIQAHEMDDEVQKFEESILFFADAYNLHGPGSRRGSTVSSPEFMESSPLSSGAATPALSSAATSAASSRTSSIVASETRRPSFGARLGNLLRMSALPETTTLDEYHNQFEDSAMEEVQEEIENSESDKAKIHELEAWQLEATGVDRAVRILPGVKKMISSIPDGRYAVATSGAKTYAYGCMTRVGITPPPVTITADDKRLKAGKPAPDPFLLAAKCLGYDATKCVVFEDSPSGIRAGVASGATVIAVCTSHEREKIENCGAHFIVPTMDHVKCEVEDGKLKFTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CAC8</accession>
    <name>A0A8H5CAC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_014719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000199">
        <property type="protein sequence ID" value="KAF5338175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CAC8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5338175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="390" mass="42675" checksum="C1E16A831AB683B9" modified="2022-01-19" version="1">MPTVFVTGASGYIGFDIVHELLKAGYRVRGSARGSKLQGLKHALADVPEFEAFEIDDVSSADFTDAFKDVEAVIHTAAPVPARFDATTGLKAVVDGYLNIVQQAHKAGVKRIVVISSIVAFPNGGPFGIDDWNPVTEEDVSSAPGNVWALYFAQKKFGDQVILKYAQEHPEIDVIIFSLPWIFGPLRPGFHHILGPSSSGGQSLNEVYKSLTSVAYIYKLLNPHNTDFADPIVMDIRDVARLVLAAMKAGPAASSPKQNQINQNQTENDENEDQSQGRPQVKRFALLAPYFASYKDAVGYIGEVYPELKKQGRLMDEEKAPGVPEVLLQSGTQSGGGSAKMQIDWKRIEDVFGLKDLEKSCKTWKETVVDTVGSLLELEKDWGLDSGKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CBL9</accession>
    <name>A0A8H5CBL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000191">
        <property type="protein sequence ID" value="KAF5338822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CBL9"/>
    <dbReference type="OrthoDB" id="3051288at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5338822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="139" mass="15467" checksum="CDEA79DA24BAF2C2" modified="2022-01-19" version="1">MKSTDSPVYPLSVSKTIRRSIVLDSMNHSDENLPLERDSNHLNSDTSRLNRAVSVQGPPSAYNQARVTFADDVERRAGLRRSLSATQRARDAPFPTRPVLPVPLSLSMHGPNARAVRLSLDARASVIRQRYRSGMTEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CCK6</accession>
    <name>A0A8H5CCK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_013296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000186">
        <property type="protein sequence ID" value="KAF5339245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CCK6"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5339245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="38883" checksum="54546A5EA26303F5" modified="2022-01-19" version="1">MATHPSSTMQPVYIQTYYDQTDSVAVGGLQRMNGAAQPTHYTMAGDEPPVSGDDRYLTPYHPPQYYFPPFNDTARLSMYPPRSLHPPGFGAYSVPPTIERPQLQVGEDRLFNSHPHSIYSSSQHGAAHPPATPSLGRYLPPRPYREDMPAPIPLHPLTPPHATTTLHPRPDILDLQSLSPEYNQSQSSFSPPASSPGYSGSETGIGTPPFFAEPSNCWQGPGDQVARSLSNPACGGFVGKGGVYSNRASSSDGMPFVPWTTRDAARPHLDGASATGIAKKTVASPANEMAAKNRRLGKNKKSYTCDLCSASFTAKHNLTHHTNSHFGIRNFQCEGCQRTFVTKHVLKRHWDSCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CEV9</accession>
    <name>A0A8H5CEV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine kinase</fullName>
            <ecNumber evidence="4">2.7.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_014554</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4"/>
    <dbReference type="EMBL" id="JAACJM010000175">
        <property type="protein sequence ID" value="KAF5340476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CEV9"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="221"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="497"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5340476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="637" mass="68915" checksum="4A406428B8BC6AE8" modified="2022-01-19" version="1">MAETKGLVNGTIGTVVDIVWKPGCARSDLPLAVLVEIPTYTGPTLWRSEPREGFPEGAPIVPIAVYKQVFEFEGQPCSRLQLPLRLAWAVTVHKSQGLTIKKAQVGLGRKEFCAGLTFVALSGVTDINGLMIVDKFDYSRVKKLGSAAWNERKVDFIRRYNVFLEQSNRATVYTCYMSTFSESQASEPSSLDAHDYASYQLLCIGHPLLDIQVRHEAEKLLEKYNLKENDAILAGEEQEGIYDEIAEHHQPIFGAGGATNTARGAAYILPPHTVAFTGSVGDDDFAEHLKAANRGEGVLDLYQVSKGGETGACAVVVNGSNRSLVTTLRAAKDLTESHLFTVELSAVIASIKVLYIEGYMLTHDPEIVVNLAKRVYEMGKLIVLNISAPYIPRFHNSAIRRILPYCRVIIANEAEALAWAEANGHGVPVPSSLDSTRPLDPPPNPGPTNARDTQTRDTLIPQIAKAIALQPLQSSPQPPNTTPTPIPNPVLNPINLRQRIVIITSGSHSTTVVLSSSPDNPRFYPVRPLDSAAGLVDTNAAGDAFAGGFLGAYLTLRHRNHDVGGVDGVRLELTQGTGGLDEENEIELKWLDDCIEVGHRLAGMCCGQVGGQYLWPKVDVLGGLGSFTQTLGLGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CGV2</accession>
    <name>A0A8H5CGV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000171">
        <property type="protein sequence ID" value="KAF5340846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CGV2"/>
    <dbReference type="OrthoDB" id="78198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48471">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48471:SF1">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="687"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5340846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="891" mass="100930" checksum="39879E8C149C14F1" modified="2022-01-19" version="1">MGSKDQEEPSGVLDKASLALEIVVKRMEQWFSVLLQEEGVTAATREAEKLTQELKVFLHWTLDMQAAGMDDSLPFIDRHSFCHMRNIIRVSNHNNADTPPAHTLSQGHLPPVLNSTAPPTPSLALSNPNAPPSTPPLQSPFEPPPYSSAFVNSTHGESNRYRVWNRVPTPQEIAAYWPLTRDAGGYVITKGTRIGFVADWVIVKALTLGVSCMYQKAFDNFDVALMEYVQVFEGTSHSYECPEICGVPNKQNPLFSYTNPELIDQDLEFEVDSHQVIHVSPVLIEEVRQLAVDDAPVSITHVTVDRGSGSGWDADMPGAEIWIVIVKHAHFFDSDSNLLNIAKINIAFTISTDSHHHIYTMGKRKQPTFSRPAPATHHKFGVSNDGQQFTYRSQEVSHDQVFSSSASEYDGGSDDDNGDFFDDFAGEQNNTPFINDSESTPVFNDSRLQDLSTAESPDLAHIHVTQKKYLHSVDDFPSNTGGLSEDDTRYWEEERTQHVLILATAYIYYGALESRRIHSERHSERRLYLTRPYLLPNPRSQTPWQVLYEGRNDWAFIMTMGLNVAVFQRILDSGFERYWNENTITHQDVPAASEPRVYRRSLDAAGALGLLLHYLNSTMRDVSLMQIFALIPTTMSRYLNFGRSILLMTLHRMVEACIHFPEGDEFVELESLIVARHPLLTGAFGSIDGLKLPVQTSSDEEIENATYNGWLHEHYISNVLCFSPEGVIIACQLNAPGSWHDSRVAHSIYNKLLTHTPEGYYLIADTAFPRGTDQIAGRIRAPIKEGTRLPADPIERSNLMLVNQQLLSFRQTAEWGMRSIQGSFGRLRIPLDVNDDAGRADLLELCFRLHNLRTRMVRYNQIWSVYLEIWQANEQEWVWNEFENMVFGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CHN0</accession>
    <name>A0A8H5CHN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_014742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000164">
        <property type="protein sequence ID" value="KAF5341439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CHN0"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="452"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5341439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="762" mass="84189" checksum="8215AB38E01BB27E" modified="2022-01-19" version="1">MTSLPPAQEVNAFTSDDRAPESFNCERCGVFVKKGNEWGYFKNPAGHDKRTCKDCKRYYSKGVAQRQDTLSLSRSTSSSTHSGMIEPLPNPDMIASRVNAAQRANASREMSHVTPMSNSGPYVSLPNLSRSSAVLSGPHGYVSRPRATGYSPAHQHHSAQTDLWRSKAYAPSGETVAVNITVGHATEGKTGHELLNGISDSIRDLDVNLTVPEVRHAVLDLMKPKINQFSAEIMGFCFKFDEFNLREISKSLNVDMDGPTLDRRTPYFRPQCMKADKKTNQLKFHRPSTPFRLLLLISAKEWDRYESLLEAQAHANDLPIIRTTSTSSSHSSWAKGLQSIPSTATSSALNTASPKTSAAISSVSMTDLIGDDSDTARTSAKRPRSTSSVTPTTPPRAKRAPAPFLSPTENRITSALIAGGLNSDQHSDISSLTTMQGLVAPIPTVSFLDIINLDNVHTRFIFDNAVLSSGAHLQADLRFESELGVGAFKTCHPAKLICSEQVMTANSVVMKELYKNKGLRENGKVVNRGRYSGVVEFDGIMIEANVHYYAVALMEFAYAYIERQKLEKGLPDLPIPNLRYVEAAVFMVQNNEIRHSRSSTAGPKRTYLLEERIALPPGQDFIKYIHNSSPLPAIPPEHPEYNTALFLAAVQHLQYEKTYQSAYVSDFQGYGGLLSDPQIMTSPLVFLILGMWWYTKNISSKLLQVIFREGAEAAALDPKTSLFGDGNVQSGFEKFPLNHQCEGNPFCAWMELKPLQNELQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJF7</accession>
    <name>A0A8H5CJF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_013386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJF7"/>
    <dbReference type="OrthoDB" id="5231159at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5342830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="405" mass="45949" checksum="FCECBA5C716F869E" modified="2022-01-19" version="1">MSSHRRQGDGHPLIKVMEEHLMTMWVSIALRRILKDIQKRQLPSSYEENLATDCIICILSFLRYSLEHHGPPAAYTVLRQGVLASLLDVCRYLKQEPNSSNGLPEVEDHFISFLEMLIPMACHRKICKQVNRPVLHILASRNAVDPLRCFTNIIAGQKSMEVEYRCFALKRFCNNPDCPYKGQANKARRQRCTGCLVRLYCCVDCQRNDWRVHDHRKFCEQQSRHQCPMTFQVSDVDRDFLQYLTIRRVREQSSHIRVLKQKLIDDSDPERLRRNPEPVFVVVLGLAFFGVESNSHPSIQVQCLEPYLNARSRRNTSSSSQSTSSSTSSSPSRYLSKDVLASISSLCSGAGMDPVNSGSERMTIVHALFPGAVDAPVSVVLGVQLGQLDQELEDGSWGDSIRIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLT7</accession>
    <name>A0A8H5CLT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_008862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000129">
        <property type="protein sequence ID" value="KAF5344070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLT7"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="314"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="503"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5344070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="554" mass="60098" checksum="D75FA288D366E15A" modified="2022-01-19" version="1">MFSTLGLFSKQACPDEACRRTGCLFVHGVQNAEPLVIPEPKVVPAKRPAAVSHPSSSSLPAVSSANEPPRKLQKVIHANPKSTETPRTAVPVLSIKPALSTVSIVVRQAMLRTVYDHYVVLYDQILPSHPHLAHDHALKHEEQAVIQSVAAIKRRPVPTSYSHPSVGTEADLAACAATKKSLSSFRLSSQALDPHVLSIPDLDKWGYITTIPEGQGGSQPSMTGNVVKCERCPEMFMVSAQYDPNACLHHWGRAYTRSIDGERTRVYSCCSKHASEEGCARGPHVFYESNPEILHARHPFSYLASSSAFRSALDMVALDCEMIYTTGGMRVARVSLVDHLGKSVFDEFVRMDDGVEVLDFNTRFSGITASDYASKARLTLASIRQSLDALIDTQTILIGHALENDLKTLRIIHHRCIDTAILFPHPAGAPYRRSLRDLAREHLQTRIQTGDGSTGHSSVEDAVATLDLVKFFIMNKGTISSSVSSSNSTSTPRHSSTPRHQGSPPTSRTPSRLTTNSRSPSSPTASKTVTTSTKASPSSKSSSSGSPSMSVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CM13</accession>
    <name>A0A8H5CM13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000127">
        <property type="protein sequence ID" value="KAF5344239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CM13"/>
    <dbReference type="OrthoDB" id="2790258at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5344239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="45816" checksum="DC12FF7D28F2E53B" modified="2022-01-19" version="1">MTNSAGRVLFTSDIWSCTTLASHVAVTAHYLAYSLEPGHHLILCSELVAFCIIHSSHTGQNIATIILDIGVITLDTLMTHVAEDLDQLDIPFSVEGNHIRCFPHIINIAVKTALKYLTCVNIWDPEAEGSDDPDLPAPSALNDDPEYKVIADAWTQVTTCQASGQHRQAMSEIIVEGNKNGGWGNLPEQLRNIELMKDVDTHWGAAFNMMDRLLELNLEVVSAEKTPTLSVVLPLYEQLITYLENLKPQLPKIEHSIQAAITKLKEYLVKSCKVKVYALAMALNLMFKFEWMEKHWTEREVIVAKEAALMLYAAHAQQSGLARFAVLGQTPESSPGSSETTPPLTPDQIQARQCQEDIAAVSKEIGEFKKAVAIPACTPVLIFSNPSLQVTTSEANHSNSEAYFPHQYLVLQTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CME3</accession>
    <name>A0A8H5CME3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000143">
        <property type="protein sequence ID" value="KAF5343297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CME3"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="326"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="732" mass="82845" checksum="7C557045FA82B7F7" modified="2022-01-19" version="1">MLINSALKAMFDDDPPITYFDAHGRLIYGSRAQRKPDVEAFASSPDFPNTLEHLKAYWPMVVVWLEVKRVRQRNGYVLDWTGGTGIDIDESQTKRPSPLKGDEVATDTSPNQPTDSSVQTGQKRKRGNAGDNEKPSTLQNGPSVPAKLPLHASASISASHNSEGTPNKKAKSDITHDVHDLQIQLAGYGLEMLSSGLLRHHNVGIAVDGTCFQLTYYDRSKVVLSQPVNMDEGKNLLLFLALLYKLGTLYDRKSPSVPPFTADENHFPRIDPVCNSGYGDFEELQARQPKGLVHNRNSEFPGANAFHSSKLYLDERTTVQLQEILHRAYSIIGRGTTVIKAKRIKGRWDERIQDVVVKISFPGAERPPEQVLVEEARNAAVGNHIWALNHLPEILSYHEYDLDKNTPQPRLAKYLTDALGEGAYERRVLRILVLRPLCPITHLKEPGLYAQVFYDILQIHRWLIDHAKIFHRDISMANIMFVRKDGAVCGILNDFDLAARLPLPMKRYSQQRTGTKPYMSHDLLDPVSQRFYRGHTYRHDLESLFYVVLILTSHYNGNLDQESIHGVAMVPMPYFHDWFTSTNVAVAEKKSKLLQHPDAFPTQNFFKGFREKLLTMLGCLVKGHSQKAQQIINESLEGLKDSTRPGHESDEDLDENSEPVSDVDFDWLTLNKTITYENFKRIMGKFARTPLVERYLDHFLRPLDPADFEPARLKGDGNAGKMEGYAARNQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNP9</accession>
    <name>A0A8H5CNP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000118">
        <property type="protein sequence ID" value="KAF5344808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNP9"/>
    <dbReference type="OrthoDB" id="2640446at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="29981" checksum="6D822D1EF4399806" modified="2022-01-19" version="1">MAMLYATYIGNHTLHKAIDMKTFYEKQFRTIPDISELHPFSSIVYVKCTLKPNKLEDQAIEGHWLGPEKESQGYYIYWPKKKSITVTNQPIQLSEEEDNDFINLEQKVPESDTVDPVIEITKPIAPKIITGRRPITRSMMKKTGGVESANLLTTILAQVTSKLEAYNPLSVVEAKCQPDLPKWKEAMDKEMRRHKEQGTFIPVYAPSDANILTGKWVYRTKKDEHGKVKEHQAQLVVCEYNQIPEVNYFPDETFTSVAKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRV7</accession>
    <name>A0A8H5CRV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_011393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000107">
        <property type="protein sequence ID" value="KAF5345923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRV7"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="55"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5345923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="961" mass="108454" checksum="F2481D2D964F5531" modified="2022-01-19" version="1">MPRTSAPPSQLPSMPTTSAPSSQLEDLEKNEKQFDTNGAGRFKSTSDSDACFKLWNMYIGQAHEYDKALLEGWKGDMEGMLLFSALYSATLTALLVESYKKLQLDPADLTTSLLTTMISLQLASSNGTTPTVGLPDTSFKPMTSSLICNMLWFLSLALALTCSLLATFVQQWTRDFLHKTTMRPSPVVQARVLAFSYFGLRRFGMHTFVDVIPILLHISLFLFFAGLVAFLLPVNLPLTILMACVLFIFVLVYLALTLYPLFSLDTPYRTPLSDFFWRIANGFAVRKHGLSDDNLSLTQAMLEKSLHKSSERDRRCMEFTMTLLTHDTELVPMFEAISEAFASSRASGVRLENFGIVAPLLQSSIPEINIISRICNFISGSNTPGESTTKAMKSCLHALNLLARLVINHSMENIGTSRQYPTFWFQRDLLALLSSSPSLPRDYLISTIALLRTSRVQGFRQCVQRMFEVLSSRKTSTEQLAEVRSIFTNLSREDIDWTSEKFTHHFNQLGGTLQSACMSGMTETDTAALVQQVQEHIAQLMDMSRWKAALISVLSQFLSEATGAGLVPFEMDRTFILIHSSIPTLNVFDQSLDVEEDEAQATYLLQSTSPYPQSVSPELFALVFRLLFSTKRGLHYTGAVESRVVLYKYLYNGTAEQRKLLIESDSACSMEECIFLDLSSDGAGDLASWCISGMDRAYYGMGFWESTVPPRLLSFAKGIFRLIPTASTDFTQYCWWSKPSTDTERILCKDIIQKLKHLWRSYDIPNSHHDDISSITPTMGDIHTLGQRLLPELPVPECPPLPCPPDRYQHWITEIQDYVLSMHLLITAKYINLMAEDTEDRVFGDWDNIFTSIQLHQGHIYEIAQLHFAKSVMDLMSLCPWNQPNESGKSKLFYNHIWCLSRTNWCWVTDMESAKILAEAIQLHKNDANFNGIVWYEDVCLARCMEVVQRAGAAEEPLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRZ3</accession>
    <name>A0A8H5CRZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000111">
        <property type="protein sequence ID" value="KAF5345562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRZ3"/>
    <dbReference type="OrthoDB" id="5966500at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5345562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="87" mass="9836" checksum="17CFFE8FB6609105" modified="2022-01-19" version="1">MVSVRSAHSAVKGMASFASDIQVPVRMTVLELLTHIPPYAYIRHPQEVVLAKNERDFPSKPTEARVVERVNSVDAIWNARRRRRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CS37</accession>
    <name>A0A8H5CS37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000106">
        <property type="protein sequence ID" value="KAF5346028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CS37"/>
    <dbReference type="OrthoDB" id="2898134at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5346028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23086" checksum="5469FE541545DD71" modified="2022-01-19" version="1">MGDLNACTSISCASKQHPFHISLDSKPSNSHGKQLLQCVDTCNVFILNGAESIPDNHFHFMEHHNAGKDDQGKTIYQCTVIDYALASMECLPFITNFEVSPCTDWSDHSFLSLCIILPGGPPSFPSSSYSHLWPKFHTSLISELDQLLDHLMKQPSPSLEEQWSNIYGLATLKDHAHPLLVVYISGACSNKGHLMPLQGPAYFLGSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT50</accession>
    <name>A0A8H5CT50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000092">
        <property type="protein sequence ID" value="KAF5347539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CT50"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38876" checksum="70AC5A77E0C62463" modified="2022-01-19" version="1">MMGPTPSKDFNPIRDLPDMKGKVVVVTGSSSGIGFAILQHLCRLGAKVYMTARSETRATSAMERLEKEGKEPGNGEVLWHQLDLVDPRKAKESAEKFMEKEQKLDILINNAGLIADRGKANVNPDGLQDTMAVNYLGTYVFTQTLLPLLEKTAETGADVRLINVGSNAHEEVTFTDFSTVEAWNHTFRWSLLPTFSRYKYSKLALHTWSNYLARRLTDKNSKVLLIVAHPGPIMSDGALSNLRSLPVPKFWVWLLSLWLYPQEMGGYAPAYAACAPRADALPNPAPNETETLAPKSKDCFKPNAHIVHGTYIVPPNINAEQGAAARDVEKQKALEACTRSFLEKIGLDVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CTG1</accession>
    <name>A0A8H5CTG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000090">
        <property type="protein sequence ID" value="KAF5347657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CTG1"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5347657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="19449" checksum="329144F164DEAFBA" modified="2022-01-19" version="1">MSAITRNRQIPSITLQTELIGKVTGRKIDTNTLIDSGAEGIIINGQFTQKHQLTLLPIKNPFPVQNVDGSENTMGWVREYTIQNLRIYSRDSEVYHEEQAEFYVTDIGDHDIILGTDWLEEHNPDIDWSDSWVDMTRCPETCITAKPPILHLKTKPLKSTVVDPRTHHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CUG1</accession>
    <name>A0A8H5CUG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_010042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CUG1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="90"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5348090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="300" mass="33308" checksum="A3BF649A6A1983DB" modified="2022-01-19" version="1">MAYVAVDEDERLEEGPEGLQFKSFNPTNVGVGNTDRGYLQDQPHPSKSNLSFWNIEYYQSYFDIDTQTVLTRCYSTLLPFSQSFNHFIASNLNPPDLYGPFWTLTTLIFTLFLSSSLAASISAYLSPDAVEDYDYDFRLLSVALGLVYAYGLAVPVLLWIALRYLGVGEWSVIEAVAIWGYAMFVWIPVSILCVAPVPILRWVLVILAFASSGYFLVRNVYPILASAEAKALRLLIIVLVVLHAAVALVFKILFFNYYVVEKYGIDPDDVLLGGGDDSSGSDGGNTTAEAVRRMVRAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWU3</accession>
    <name>A0A8H5CWU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWU3"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5349038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="237" mass="25388" checksum="AB400EBF84F65240" modified="2022-01-19" version="1">MRTQIALPSPNPSKNFRVRKKSQTNRKSTAKAAASELDVLEQRVVDLGDRLDSSSKQHTDEVRNILDILNNFGVDSHLADRVQLDDITRSLSSLNNSVSSLARTASSQYTVAEKTLQDIAVGFSGLSGQLQDFAGVNNQPVDAITSLQAENGELQSRALNGPPIPSLPSSLPVSPTSQSIHGHNPSSFSSLSADTGAYYHAVSIIRPHHRSAKSPESLGLNDSLTTVLLLLPIVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYK6</accession>
    <name>A0A8H5CYK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D9758_014624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000080">
        <property type="protein sequence ID" value="KAF5349433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="935"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="54"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="389"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="712"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF5349433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="141268" checksum="81E6CD86BC6A7F06" modified="2022-01-19" version="1">MLDVPDHQVEEKSGEHSKISPPQESKPSAEPGTAPVGFIQLFRFSTRFELLLDAIGLLCAMAAGAAQPLMTLLFSDLTMAFINFQAAVHDPTMDFDAVARDFRHTAAMDAIWLVVMGCGMFVCTYVYMYIWVYTGEINARRIRERYLQAVLRQDIAYFDNVGAGEVATRIQTDTHLVQQGISDKVPTIVNYLSSFVTGFILAYIRSWRLALAMTSIMPCMAIMGGLFSMFTSKYTQTSLNAVAEGGSIAEEVISAIRTAQAFGSQRILSRLYDKKIDGSERVDRRGAIWHGAMVGSFFFITYSSYGLAFNFGTTLILHGQATSGEVVNAFMSILVGALSLGYLTAETEAISNGQAAAAKLFATIDRVPHIDSADPSGLKPDPLSVKGEITLENIKFSYPSRPEVRVLKDLSLNFPAGKTSALVGASGSGKSTVISLVERFYNPSQGVIKLDGCDLKTLNIKWLRSQIGLVSQEPVLFATNIKENVAYGLIGTVHEHVDEEVKFKMIQDACIKANADGFIMKLPLGYESRGGLLSVGQRQRIAIARAIVSDPRILLLDEATSALDTQSEGIVQDALEKASAGRTTITIAHRLSTIRDADIIFVMGDGLLLEQGTHDELLRSEDGPYARLVQSQKLREVAHEDDQDVNLREGFPFLQKSTSHSPSKNELVEAKEQLGSDLEANMRFQKDLDKYSLPYLFYRTANLNSDGWRTYAIGAVCAILGGLVYPAYGIVYGINGFSKYGHEMRFENDRVALWFFLIAILSGSFIGYQNYCFPATAATVTAKLRRLSFKAILRQDIEFFDRDENNAGTLTSELSDNPQKVNGLHHSVLVYSGRWKHRGAHFFLEDWSRGIGCNQFVFWFIACTPLLVTTGYIRLRVIVHKDEADKKLHSTSAQLACEAANSIRTVASLTREEDCLRLYSKSLEGPLKTSKRTAIFSNGLFALSSSMVFFVIALVFWYGSRLVSTLEISTFRFFVALMSVTFGAIQAGNIFSFVPDLAAAKSAAAEIVQLIDSIPQIDAESSSGESLRLDHVGGQIRLDNVHFSYPTRPGVHVLRGLNLKIERGTFIALVGASGCGKSTIIQMIERFYKPLAGHIYLDDTPITSLNVSEYRKTIASVSQEPTLYAGTVRFNILLGAIKSMNKVTQEELEDACRQANILEFIQGLPHGFDTEVGGKGSQLSIGQKQRIAIARALIRNPKILLLDEATSALDSNSEKVVQEALDRAAKGRTTIAIAHRLSSIQNADCIYVIKEGRVAEAGTHENLLARKEGYYELVQLQALSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CZ94</accession>
    <name>A0A8H5CZ94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000075">
        <property type="protein sequence ID" value="KAF5350313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CZ94"/>
    <dbReference type="OrthoDB" id="10415662at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034395907" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5350313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="76" mass="8409" checksum="F08A99BE6071527F" modified="2022-01-19" version="1">MQYKLVVAFAISFLSTFVAASPIPAPEAAVHAALRLPREPAPEIVPEVVAREAEHENVTVDVEEREPEPVCRWDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D032</accession>
    <name>A0A8H5D032_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D032"/>
    <dbReference type="OrthoDB" id="10444989at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="233"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5350273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="109560" checksum="B83B7F5EB2954580" modified="2022-01-19" version="1">MRLLDTTTLQLAYFAKEDETPPYAILSHTWGEEEVTFQDLTYNPTQARLKQGYDKIQKACALARKYSFKYIWIDTCCINKESSAELSEAINSMYRYYQNSRVCYAFLSDVDPDEDPRLKHSGFQRCRWFTRGWTLQELIAPGTVIFFGKKGSEWKEIGTKASLQDLVTVITRIPSTILSQNRSASRYLATCSIAQKMSWAAKRETTRAEDLAYSLMGIFGVHMPPLYGEGGTRAFLRLQEQIIKYFDDQTIFAWRAQRTSSSSPFPPDSSNSHSEDSEVRGLFARSPSEFLGSDNIVPFSDPGEISAQQGTRYSVTNLGLHIRIPVLRVRIPSLALLDPREYSTPDERHPNIFLAVLNCRRVGRDRPIAVYLRKESKMQYVRIFPERLMLGQNGGANTKVVYVKEKNSLEMAGDLDMVNLKAGWEGRHSFKFRFPAKSSMEVLGWYPEEMLHCIVDDEATITAIVHPSLHGDFGLMRLRDKSKNRIFVVVFGFNLSAPYDNQNIWSDIIVECDGEGQAESLEDIHQSYLSHAGHSGHRTHIRAQPLDRVVKPLTDADDVVMAVHKMPEANQCLVEIGYASTRTPRIKNHKTSQISQIIAPFSSTYAFAVQVHLPSDSAHMDAMLQEPKPFLLPKEMWTDDIKTPEQQIIRFDERAGCDVGFMIFRGVKAKDRDELEVAHDSGTVPFAIALGVHEHKAWVEVITSTSIKTLVDNATESIQTDSSGSLRTDLEFDLGRLQTSAFLSLSQSKRTSPSSQSLLSIPAPKTVDGTTCHIQIHIRENPEVEELITHWVDIHIGFDKERDTEKSTMVPTPAEDNRCRSRVFKLSSIMNSLQSRLRSPHSMDDNTCRRSLSTRATHTSTHGCSVAESFIFPRPAALASSHWKSSVSQIPLRPCRSLAFARLETQAHPSSCYRQACLNHCRYHGTMHNPTANPTTRRLCLFPALRLFPMRQPFPLLTSTRLRAWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D1Y2</accession>
    <name>A0A8H5D1Y2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D1Y2"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034588021" evidence="1">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5352189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="31360" checksum="74EA4B2FC158235A" modified="2022-01-19" version="1">MSIFLRFLTLSFALGFAFAQDFGVPSSWRKPSTSRSYNERVSIARKAIDAMVPQMDPSSAQFNGLSLWQSGNVFGSMASFDYITGSHVYKDIVMKGLKTMHNRFRPDDWEWWATSAFYAYKAYGDSTHLSYAISTWQYVSEYVISPKDAASGSHSRKSFSLATTCDGKTMAGGVFWQTLPDSPVVNSITTGEYMTLSALLAEATGNSTYTKAAILTAQWIENHNINLENLVLDTIDSYTCTKGQPNNMMLTYNSGKYLEGLSVLTDVTGNNFWRSLYVFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D220</accession>
    <name>A0A8H5D220_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000067">
        <property type="protein sequence ID" value="KAF5352202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D220"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5352202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="21531" checksum="924C5068874131A7" modified="2022-01-19" version="1">MEEGMETHYCAALRLCVYMHISTSLVCSAIGDTGVHHAFYRPHPPTSSTTSSGVITTQDASPPPTDDSVDYQGNLQAIQNLMGLHADTHAAITPILSRLSLSSPVSTTVLTILTLLIPSILFLSPFIPTRLIAFFWRCITRIIIQPTVILTIPSTSASRRFQPSSELPMDMVTLPNVHTNPPNSPSSRVLFPKSFTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D5A5</accession>
    <name>A0A8H5D5A5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000061">
        <property type="protein sequence ID" value="KAF5353854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D5A5"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5353854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="128" mass="15180" checksum="2A0F8159AA5E632E" modified="2022-01-19" version="1">MKRYLSMTFVSLYYPTLWRAIKTGRDLRFDEFKKKPLTFTSYWMIQATWTFLCPPSLGPYNYAIFSLFAVLFLFENIADYHKSTWRHSKELKQQDDKFISIGLWGVSRHPNLDILKADIVVSLSLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D6D2</accession>
    <name>A0A8H5D6D2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_010723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000060">
        <property type="protein sequence ID" value="KAF5354424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D6D2"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="129"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5354424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="640" mass="71621" checksum="89BDD9750CCCBDEC" modified="2022-01-19" version="1">MADLNEKAVPQETRQENARGSITKKEDDSVSHHEYPNTSNGTRGSFENINAKLANPLAGISHDQLMADAKLFAETHGLEHLTLEFQKGALVAQDPTAFESLPMLDEEDKNVLRRELTHKWDQPKMLYYLVLLCSMAAAVQGMDESVINGANLFFAKQFGIDPDVSDRNSWIFGLVNSAPYLCCAVLGCWLTDPLNRLFGRRGTIFITALVSFLACIWQGVTNSWEHLFVARFVLGLGIGPKSATVPVYAAECAPPAIRGALVMMWQTWTAFGIMFGTVSSLAFFPVTDKPHITGLNWRLMLASAGIPALVIVVQVFLCPESPRWYMMKERHRDAYESLARLRKRPIQAARDLYYMHVLLEAEKDISRNRNRFFELFTVPRNRRATLASFTVMFMQQFCGINVIAYYSSNIFKQSGFTDQESLIASWGFGMINWLFAIPAIYTIDTFGRRNLLLTTFPLMSIFLLMTGFAFFIPPGDGRTAVVSLGIYLFAMSYSPGEGPVPFTYSAEAFPLYVRDIGMSFATAVLWFFNFIIAITFPALLKAFKPQGAFGWYAAWNAIGFILVLLFLPETKALSLEELDQVFSVPTHIHAVYQLKALPRNIKKHIFRMKVKDVPPLYEHEGAVGALGGMKTYAPGGAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F6I9</accession>
    <name>A0A8H5F6I9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_018235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000384">
        <property type="protein sequence ID" value="KAF5325574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F6I9"/>
    <dbReference type="OrthoDB" id="2752996at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="79"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5325574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="261" mass="28580" checksum="E4E97B7DAF3F26CD" modified="2022-01-19" version="1">MSRAKELLDTLPSKWDPRKSQPEDHEGDSLEMNAPEDADNFDYHITTTGTLSDIFRVFTDQDWTPTNEVLAQQVKHDSNEHMIIIATDGSCVDNGQESAVARAGIYLGPENAGNRSIKLPKHVGDVPITQSNQAAELVVAKVAPELIQRMTPMTLETDSKYVISHLTSSLKKMEDTGYPNVNNADIIRAMVANYRRREGPTSIVWVKGHNGHPGNEAADALAGAATNKDREDAIALEIPPELKVTGVKLNALTQKLAYNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FAV3</accession>
    <name>A0A8H5FAV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_018269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000333">
        <property type="protein sequence ID" value="KAF5330101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FAV3"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5330101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34315" checksum="5B0A03CB918DBA20" modified="2022-01-19" version="1">MSTVLSAHKPNLSVATTGTILPYDDDEAGTIVEPNGRPHWRYFMTDIDPEWCTIPLAVYCFMTGFIDCISFSAIFVWCGFQTGNFAQLALALARLFETFSPTGSIHDTSFHIADRQALVSLLTFNLGALLGHIGDRVGSHTRLWLVLGTFTQALFTMAAALTIWKSTQMDSSGKSIADDRGDPAWTNALSYVALGLMSASMGLQGIMGKRLNTQFTTTGALLVSNLCFLTSDLVLTTVWVELVTDPKLFYHQRVKTRDHKLIAAISLFTGVFVSRAILAKTGAAGALGVACGVRLVVALGWVVVPGKSAKGGKGLLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FEL6</accession>
    <name>A0A8H5FEL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_017589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000277">
        <property type="protein sequence ID" value="KAF5333959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3266602at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1730"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1893"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="609"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1490"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1602"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1733"/>
            <end position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5333959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="2078" mass="224058" checksum="5B647FBBDF164C1A" modified="2022-01-19" version="1">MDATCASVSTSTEASGASKADELDGMKPAIQAGIGFEAVAGAENDADGVPVPGTTTTTPSPTATANAKPDNKRLKKRKMILDPKRIAQLAELDTSSSASPTSSTSTTPHPHPIPNPLPQSRISTPIVIVLCSSPSCNAVLTPSKDGFEGCYLRKCWRCRGFESPLNYVSGSESDWSRMPSRAGSGSSGGNRSTSTSTPALGPVAGPALVSGLVPIPIPMGTRTNPSYSSIAHALGPLPPPSMSISASHRHSPYPYPYPQTRPRSRSTSAPKLISTSTPQRTPNAPRAHTPLSNANTNANAHILLTKLNIRGNPYPVASCVVPPVPVLVPAPVPVSVPAAGGSSGSSQDVPPWSQLHQAIVHRAPAPAPGPGAPHHSQPRLGPRPRPPSTSQMQGELDIPFFDQAFSLSDISEREYPSLPYPNTTRTDICISQAVQQRERLDRLERERRLEHQRQQEKWRVNTNTRKGDVEEVIWKRREAERDAREEEREGRRRYGYLHRPGHGMGMGTVVNEGWIPHPADARRSLSQGGNGSWQQQAQVHIPSTTTATTSATPTPIPSKSQSHAQGPAQSNAIATLIPNANANAKPSGAATTATSTALIPIPAPPSGTIPPLTSTATTPTATSSSLSSFSFSDQIDTNANANANVPLPSNPNLDAVHNTNAERTGSTSTSTSLPDSDSLTHTGTHTHAHTPPNPNTPTPIHTNTDTTSSTNTNTNNADVCSNFPTHDVMSNTTTTTTSNTVTGPDTNDIDIDIVTSLPHPNAHAHTNINDVVNCSSPTVNTNTQFSVSAPAPSISADADSDSDSPAKPVGSGAAKKEEEEEEERKAHPKANADINIDMDVDVDASVHVEGEVKTPTPGLSRSASPSSSVSVSTPSTTSLPHTPAAIVKCGLGDGMDLVKAVRDAVQTAIHSTIIDHPEIDWKEFEVYPELLYPPADGSDISPRSSSLPFRPPHKTTEIVDLTLYNDDVDVDVGSGSNSDSDANTSTNTDATSTKLTPASTHVQRVVGWNQAQAQPSTSSPPHSVPNIARYTSALPAAPVLVPSHTRPTQPANQANIPCEGSTVPIPTQLTTSTRIVTPNSTIPPPGIGIGIRICSTPSCNGLIKGESTSSVKRCLECIRQRWAGRGAVVKGDKSKSKSFGLSSSTTMPTGDSDTDTDAQESNSDESEDEDEDGERGRKTTGSTTFKIRIPSILWRARGVEQEVRRAHQLHQLEKETRGRRGEMNEKEKKRNKEKQKKKKKKRVKWADGYEDSSDDRIDDESGSDDSLSDIGSGSEDESVSGDEEEEEEGKIRGWDSDLTELSGGEREEGMGMECPGVGAGRGEDLGGLGVGLGLETGKEKEKKGKEDEMSVENSAALNSVKAGEVDVDMDVDVEDHEAGVARDLKDREEEEDHPERTDMAMDVDDYDCPEGEGDAKGTATPSGLRIRIPMPLTLPLPTPMPPQRKDSSAAGDADVEMEVDDADAYDNGDNGEDAGKASPVSESTFENALTTTHTTATATAPIPEPTTSFSTPTSREDVPPPGYSSNRCTIRKCQQFLPLDYTWKLCQGCRKHHREYQRKRFGIKGREEYDAEGRENEVPVQGVESQKSIDVDMSMDANHTTSSGSGSSRGNGLVLGWNPSKKMQKATPNQATSSSASSSRTSTPPITTSSSSPEEDTIFSPSAYDALPPNYVLRDPSPKNLIVPGARICNIRACRHILPSFDEWRWKMCYLCKVKVNKTRKIREVKGLLNPQRGEKGKGKTNEQEIPDDEGGGVGVDDGILEPNAKENVELEAYIQALTTRYEEEAETFDPPRVEKRVWTGRCANQDCGVRLDEETLQEIQNKLKEWRRRGGNKAEIDAFVGSNECEQCTWRRATPEEKKKRPAIHERVIAGKGVDAVPEPREMGKIRLTLLKSAGKGTHRPRKPLPPEKPRSQPPYPEYQCLSRLLHNFQHLLTQFFEARSAYMSTHPAAIGQTQAKFRFDGEYSVVALDLGVLSRKEKVAKSVSMIVREIERVGRLSFFPNSRTSSIIYQGIATRFACRHRVVTYIPAPPSTTTKHPGLISVAQDMIGELEIVTVPIDNHRLFPGERTVVRFRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FGH9</accession>
    <name>A0A8H5FGH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000239">
        <property type="protein sequence ID" value="KAF5335608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FGH9"/>
    <dbReference type="OrthoDB" id="3252356at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5335608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63406" checksum="49D06A9D8563E199" modified="2022-01-19" version="1">MPVLRPISPFDRVPTEVLNNIFLFTTERNENQYVHHYAEFIMPLTISHTCTRWRSIALSDGFLWTNLDITDFSEIAIYRTHAWLSRSKNRPLSILMDFRDDEWDWDGKDRHHFTGRHMRVFLELLLPHVERWKSFRIYTDTWEPIHTFLSFTNELAMVPSSLQTLALLRCNAYFATEGETFQPDDLKEPIPLFGGRPVQHLREVSLVGVHVDWVESPIRNLRKLEFKYHAYDVMPSLQEFMDILSSCPNLENLAILGWGPQLSKDDFTENYVDFPDDKRLSGSPFVLKNLLTFHFGFTNVQYGLKLLSLFRLPSIKRLDLEDVSTIADPLGHGDASPILDWLSSADDKADADDDSVSSASSSPGVPVKSRRCTLPLMNVERLGLSGLSSSEPIFFRFLRAFQSLKKISLSNADPNLLLALAPQNPPQPVQPGSEGTEKTLEDSCGMLRRTLVSLATVRSRVAPCPNLVDIASRRIEGSQLSALVAKRAQADSGVQPVQKVHIEPTPPLDDDEDREELDDDDEEVDTSFDDSFSSAGISEADIQAIEECGAMVLITPGAIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHV5</accession>
    <name>A0A8H5FHV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_016284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000206">
        <property type="protein sequence ID" value="KAF5337795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHV5"/>
    <dbReference type="OrthoDB" id="3259198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="504"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5337795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="603" mass="68783" checksum="91120AEDB6BC21F1" modified="2022-01-19" version="1">MQEGFFTPLYPVPRHDKFEQLLAEWIVACDQPFDEVEKPEFRALLAYTHHPSSTLRIPGRKAIKNRIMRMGESSRENIKQMFDELEGKVSISLDAWTSSNGYAFIAIIAHYVTNKGKLEELLIDFRELSGAHSGDNMAEVVWETLAQYGPKGKIMAFVMDNASNNDTMIEAIERFCRRENISFSAKDSCLQCMPHTIHLAALELLRCLGAISDDDFSKALSHKAPYQDSVTAPLDCAHDDNATLQDNGEELESDDSESSGFLKSPLEKVSHCSPNRRISHSDKLAFSSGILSRLHAGLQLIKCFMSCTYDYRGAVDSYVAKDRDLQAYELYPEDWDAVEMVMGWLKSFRSATTQMSTTKRPMLSTVSVIFRGLQQDIRNILASLLDNVSPELKEGLTVAHRKLSDYYTKFDQSPFYVWASLLDPRISYAGLKEDFTNDEILKQDLEAFKEWLMDYYNIHYAGRYLRQDKCSATTDSAGNVTTTSPQKINFTARYQKRCRFGTNELEEYFKLDQQDFEMTDPIHWWYRHRKIYPNLYCLARNILAIPGSAVAIERIFSGGRDTISLRRASLKPETIETLMLVKQRVHLARNAVEDLAGGDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FJ03</accession>
    <name>A0A8H5FJ03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_014706</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="JAACJM010000199">
        <property type="protein sequence ID" value="KAF5338173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FJ03"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034157162" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="128"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5338173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="417" mass="45078" checksum="41D9E4CF27F6729F" modified="2022-01-19" version="1">MRSLSLFLIATLLPRGGWTAAIDRTDEASEASITDGKTECTSYDYPPVTSQLSKFPGNWQTAKILQNDGVALDLWNSISNSIPNIAVKSTSTSGYSASDPDCWWTYSQCTEPKLGGLQPDITAPPEPSTLGYGFDDGPACDHNVFYDFLASNNQKATFFYIGSNVQNYPLEAQRGLADGHEICVHTWSHPHMTTLASEDAFAEIYYSVRIQAVKLAVGVTPTCWRPPYGDIDDRIRAISKALGLQTFMWGYDTDDADVGDGSSVTEADVENLYQQFISKAQKGDFNNTGAIVLTHELNNFTMSEAVKHYPQLKAAFKNIVPVGVGLNITQPYLETNYTLPSFEQYIAGNTVLTGTTTNVSISSTTTSEAPAQSSSSSSSPPVNSGNSDKNGAVPEAVVFRGSVLLTGLMAVITTFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKT6</accession>
    <name>A0A8H5FKT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_012176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000170">
        <property type="protein sequence ID" value="KAF5340885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKT6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="193"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5340885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="330" mass="36036" checksum="5FA9B9914D5B307B" modified="2022-01-19" version="1">MMEMLLAMSLSKEVLLLTGHLPQSQWNRLCRSLATSKAASNTSSFCRIPLRRWGTQYSNSIPLLRLSPVLFEMLSLSVISLACLLPFFTWTYAGPNSATTTSIAAVNEMTDFGVGPSSEVTPLSAEEISELVSFAQFARAAYCRPALLEQWACGTACNALPDFVPTLVGGDGNLIQNYYVGYWESRQAIVVGHEGTDPTQLLALLTDIDIVPVPLPADLFPGVPSEVRVHHGFRTEHARTANIILNEVIRLMNGTGSKTVITTGHSLGGALAVLDSLFFSLHLPKDTHILSRTFGTPRIGNIHFARLIDSSVRALSPTQNTSFKFYLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNB4</accession>
    <name>A0A8H5FNB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000149">
        <property type="protein sequence ID" value="KAF5343106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNB4"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034986692" evidence="2">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="15403" checksum="8ED95E9CAB9B6421" modified="2022-01-19" version="1">MAARILSSSMLLVSVLTALALAAPAPANENTTLEKRIDHFGDATWFNVGLGNCGVVSFNSDKIVAIPKALYDQNNGGNCFQWVEITDQRNGNVHYGQTLDSCPSCNDGLDLSPSLFEEFDSLDVGEFPIKWSFKAFGFVPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FNF7</accession>
    <name>A0A8H5FNF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7alpha-cephem-methoxylase P8 chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000155">
        <property type="protein sequence ID" value="KAF5342838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FNF7"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5342838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32369" checksum="A3C991A3A69157CA" modified="2022-01-19" version="1">MPATLIQPSFVSAALNFFAPPLDGSRPFVDFTGPVPKPNHPRETHVVQIENLRGNEASVSLDTAGFQFYSEPAKHKSFKNDEEIKREYYPESTELIKRLTGASKVLLFDNTIRRRRLGNSDADPSNREPEPFVHGDQTAKAARNRVLRHLPENESSELLEHRFQIINLWRPISHPAYDWPLALADYRSVDPEKGLTPVSFVYPGKEENDGREAMGVSYSPELKFKYLKGMTPDEIVLLKCYDSNDDGSVAIMTPHTAFQDPTTPPDALPRESIEVRALVFYDGSIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FP29</accession>
    <name>A0A8H5FP29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_012134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000131">
        <property type="protein sequence ID" value="KAF5343901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FP29"/>
    <dbReference type="OrthoDB" id="3221775at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="298" mass="34358" checksum="4F9294B0F13043ED" modified="2022-01-19" version="1">MNVENFWKQLKHKNLHHILHPRLDQLVWILIHEVVPTYIVRIEELRSTSRLGTSKALSPFQKSFKSDWKTLARRVIPSSKYTHLVQAVHEPNLHFFQQVIRRRVYPFYKHPQLVLKGEPHGNFSKAEDGSFTDGDDQDWLGDSSQLTDGAWRGLFSSSQKRRRSSAFSESATRSPSPSLLPTDSEFDSSTQNSRPISSLDYGSEDEQELDQLVEKAQVKVQQLRRAADLIEAQLPYRNFTWLKGLHDRKLGRDIGHFVEDIASFEDSRGARPTTWASSSSKTAKRQERNTLGYQVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ18</accession>
    <name>A0A8H5FQ18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000124">
        <property type="protein sequence ID" value="KAF5344488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ18"/>
    <dbReference type="OrthoDB" id="3227568at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1107" mass="118655" checksum="14D5A459BED4F936" modified="2022-01-19" version="1">MFSPNPSCWSNTIQRLLVSTPGHRACDKRLQISPSKPKVSNFNQANCSSSSSATSFWRDFVLECILNDLSFSEFRPDSDLHSTSREENGLAKTPQTTSVDNSCDICNSRRRFIRMDKLGVGAVIMYEIPCVCQFPRKRVDLGITDDIAGYRSNSENGGKGIDELLEVMNVNVSYVPLYACTSFLTGQVMNALFHNTTTKDMRPVPAPQGQGFSVDSSSFTLFENGIPAHNTTLLHDVRKLLRPTRSSAHRYRRDQELFSNSESLVPFSTANHVMDHNIHLNLHCDETAASGQNMRPSFEDVPMFSSTVEVLYHEPAVLNHSIVVKHTPASQHSNTLLSQEVFSQAIEHSKSTPPSPTDITRLITTTRATEFFIQSQSISSALSNRSLRTRGSNRSISPVPSLSCIPCIPSVPPVLSASSMESTVSSGSIQSFPSITSVKSVKSRLGSVSSLSCYSMALGSAELGAGAAAGTTVSPSSGTGSTSTSNFNLRLSLNNHTCGNGHRRSLSSNPIPSRPVYRLNGKHTRGESLVRSCLRLKTMPTFNKTNVNLDGGLPFHASLPPLVVKSKNKCKSKSVSMSLSKSSSMTVPQVKVVQVQGQGRLLKIPSPSSFSSSASFSSNSSSLHLYQTKRMKETQNKKGSGGDDGGNGEQKAMATGSVSRRGYNCGLSNANVTDHDLMDTQNPDSGLYQCHDQCSEGDLASYRIPLEWEEDLTAELFSVSSSESCSCSCSYSASTSTSTSASASASVSTSRSGLGSVGDGTSSSNSLRDNVDVDVDGDAYASSAEAESGDVSMCTVSTSASIGPLTPAKGQSLASIQHYGYKLLPSSSDLNLKGPGGAGMGVKGTNYGVEELDVVGMKTKTERRNKLKGIETRLGVGIECDFAVEDLIEMDLGTDVGIVGLDDDDVYGPGFFRDGYGAGVGARVGTRAGFGMGWELKGVDTEGDFFSGGQRARTLNLDLPATHKHASSNTQLSPAPSPSTSHLSLSPRLDFPIPVSSTSLMFPDLLADLNSRKEESTENGGISSTFSSSSFSDRDQVSVLTSPVQKRGLTSVYIQSFKGVDHGFGWTLRKRSNSQTQKQTAVRMAGRGKENIPPLKLHLVESGDFWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ20</accession>
    <name>A0A8H5FQ20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ20"/>
    <dbReference type="OrthoDB" id="2654851at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5344936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="242" mass="28230" checksum="BD41E2BA2D46FF94" modified="2022-01-19" version="1">MRLLNTQTLKLQEFDTDIPRYAILSHRWEKEEVTFQDIQNLQTASLKAGYAKVWNACARARNYDFEWIWIDSCCINKESSAELSEAINSMYQYYEDAVVCYVYLCDVSIEFHPRNPKSTFKDSQWFKRGWTLQELVAPRNVVFLDKYWVRIGTRWTLRDVVSAITSIPVEVFEGRDINTYSVAQRMSWASLRETTRAEDQAYSLMGIFGVSMPPIYGEGGAKAFMRLQQEIIKISDDRSIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQD8</accession>
    <name>A0A8H5FQD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_011887</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000108">
        <property type="protein sequence ID" value="KAF5345775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQD8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034617419" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5345775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59072" checksum="627968EF42547105" modified="2022-01-19" version="1">MLSMFNVLLSVVCIALGVIVYRKRGERYPPGPRGLPLLGNLFQVPIRKNWVDFHRWQKEYGPFFYLNLAGQPVLVLNTRKVAVDLLERRAANYSSRPRFIVSGEYLNGRCSMILVDDGDLYLATDASFKRICTEPQDLNPISTLQSDEAALLAYDLIRSPEQWSSHILRSVISSIMSLVYDLPPLTSLDDPTIVFLLEAIARLDEAIYPGNFAVEFIPILDWLPPWMAKWKRDAIRDHKVWTAKFEKMFDTVKSSFLTGETEQSSFCATLLKPEARHGLNDFESAWLAASLFMAGYETSSSSLMWFMYHMILFPEVQAKAQEQLDQVVGRSRVPSFTDAKHLPYIWAIIKEMLRWRPPAPIAVPHATSADDYYEGYFIPKGTLCIPNVWSINRDPEVFGSDVEDFRPERHLDANGNLKDALDEGHFAFGFGHRSCVGRHVANNTLFIDIATVLWSAKILPVKDANGKPIVPSVDQEVTDGILLHPPECQFNIVSRFDEVEMILQQAREDVMKSTRYSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR04</accession>
    <name>A0A8H5FR04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_012757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR04"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5346405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="644" mass="69889" checksum="F085855BF8882A54" modified="2022-01-19" version="1">MHHSSPSLLGKVLEDTRHSGSVQVTENLDVKQSKRKIVSESSEFEGAFNEERSNVAMWLLNGASAHLGNGIDRIPVLIMELIAQSSHGPRDCEEGQKTNLKLSADLKIGNKVFLDQSRRLERRPSSIPSSLLTVMSFGDQDAYDDMHYQCPQEHFPPDFHIFSPFPDYDQARFHRPQSTYYPLVESGQQHHQLSFNQTVPSMDYTYEQNYAPAYPCSASHPPPRLTPPSLHRSQSQQVLSSADSLVTDTGHRSPLAGSLDPSTGIFYRTPEHPRLRTAQACEKCRTRKAKCSGEHPSCKRCLTRGLICQYAKEGRVRGPNKPKAKTQNSNSSSSSSGSNPSAAKGSQSTKPSSSPKTNEKDSVTHRSFSSTPSLSVSPSPSPGDSSLQTSSSASDISSSSPSSLLTSPLTASSDSTESTSPVDLITQSSHEPIPVSEHRSSRPRPPQLRLMSGSQEPQLSSRPYTSVPNVHGYPITPSHMLDVQPQSTSPSSSLYSAPKSAMAALMTSTPDSTIASHGSIPSSLPSRFQYSTHLSPPEVGIGQNGCSTPSPRQQSFDTFDVLPAQLELASFSSTGVRDHARMLTAMVDAHDISDVYAHGGLQGSNHSQELDSEPFHQTIPLSMLISVNASGTHDSELMYPEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FSD4</accession>
    <name>A0A8H5FSD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000098">
        <property type="protein sequence ID" value="KAF5346962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FSD4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5346962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="141" mass="15547" checksum="2FBA81D29ADBE48E" modified="2022-01-19" version="1">MYHTKVPKGAAGKHLTEIGASVLSDDPQSKKSNFIKRGLKQMFQRTDIVEEKDKEIQDVQDYMEKLYNDMDVQMIKVWARGEDTDVIQAIDIKELASISKIIKDVIPPDDSISSSSATAPVASTSSGSSSHVLETTNCQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTE3</accession>
    <name>A0A8H5FTE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_012673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTE3"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="395"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5349015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="694" mass="76735" checksum="6F0D02140F37BE0B" modified="2022-01-19" version="1">MDALIAKGNAVHPLSHKNSKKPQKETDNTLSSIVKNTSLPKSFQSLKHKASSNNAHNHIANKKLRTQLNRTSEHIATSKALLQDAEMLLLEDSGQMQLEDEMERTWRVGQSEISGSVGQEAARGRKEWKLEGGPYRSRYTRNGRHLGIVGKMGHVATFDWQTGQLHTELQLGETCRDFTFLHDHSHFAVAQKKYVFIYDRDGVELHCLKAHIDPTRLEFLPYHWLLASVGNPGYLKYQDTSTGQLVSSHRTKLGSCTTMAQNPFNAVIHLGHTNGVVTLWTPNMPDPAVRLLAHVGPVSCVSVDSDVTTNGGGGGGGRYMATAGKDGTVKVWDCRNWKGCVREWVVRGTGDPEVEWSQRGFLAVASGGGVNVYTKPTLVEPHHNPRITTTHQPPLYLTHPLPHRPLTSLRFCPFQDILTIGHARGLSSILVPGAGEPNFDSGEADPFEGKKGRREREVRGLLDKANACTCTGSCPSFFVLRSSFFIQPDMITLDPSSIGTLAPPSKLTTTTSVTAVSSELNSAALGSAKSDIPYARLPRYERLRVSGKVDEEDDDEEDEDHDGDGGGRKGNGNGKKEDREEREKRKMRGKGKSLKRYLRKQRKNVVDPAAVSASLGFGFLFCFFPESSPGPGLPSRLLSFLAIRKKLEKQKEERRIEKMVAIGRIEGERKPSALDRFKRGIRRGIEAKTKKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FTM2</accession>
    <name>A0A8H5FTM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FTM2"/>
    <dbReference type="OrthoDB" id="3055505at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5348746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="89" mass="9539" checksum="62CEC4F3912AF192" modified="2022-01-19" version="1">MSKSQKTKSNTNRGKKDAAVRQAAKKSKKTDSKATRFKNAQLKDALDSQAGLLYAINTSAHGRPTEETTSSVDPSVQDLTSSFVAFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FV87</accession>
    <name>A0A8H5FV87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_007852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000076">
        <property type="protein sequence ID" value="KAF5350249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FV87"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5350249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="886" mass="94379" checksum="47749AA8971AF208" modified="2022-01-19" version="1">MLPEPSSGPPPSSESSISISSAPSSRVISPAMTTISEFSSPPSILTASSSPASLVMPSTGTHSGSPSPFIDGLALQSQPSSQFNAHYTNGESASSTVPSQSQTPDVDPQIIEALRSKDRLYVLKLGEIMEGLIKEKRRDFIGRADLSPSTSYQRLLVHRCSAYYKLTPESDPVTKTIFVTFSAESRIPGRRIADLVPPEPTTQPAFKIMRRSQQDRRVKPNSHAGSVTGEDADSSDVEPSEAGSMGGRSNATGGSGKKWMTIEEREAAYNAARNRIFMDFEEKEKEKEKDMSASSSSGLTSASASHAGSSVGDTDDASSSLATESEWSGPSFNKKDSRRSNTSSSTRSIRSSNVPFPNGSGNSSRNSRASSPSFTYASLYEPAPSSTTYDGPHHVQHSAPGAYPNPPLMYPYPPPPQSQQPPPNHPYMPPYPYYPPYAFGQPPQPPQNSSDGPPSTPSEVYPPPPPHLLYSNSYMWPPPANPPSVHSAPPVPSQPPNGRMPGPQPHQLPQHPQPYPQYMHPPYPYPMPGYYTSPPGSGPVHSPPNAVGQLFNDSRIPGSGNGNVHGNAQRGNPNQRGMPRNGGNSVNGGGKRNNAPLPRPAWSYGPGVGMGGVPMNGGNSTMNGGGEIIGPRLSSSMRRQSNTSTGSSGNYRPSPNDDVASTASSSTSSSSRRTYTSTASSQQHPLPARPDWAVGLKPDPTLHATNRHHDHSHTNSRNMSPISPPRALSGGSNVSTRRPQDQTQPVYLQSTDFPPLSLSSPEKRTPAVGGAWTNNATRSLLMTPPSQSMPGNALVPQPGLTHPNVVVNNNNNAMPRLDDSFDRSSSKAAELYNPKVVKRPSPFDNRLMNATSDKDQPKGGEGGLSEQMYSMSLAESSHTGSSSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FWP7</accession>
    <name>A0A8H5FWP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_007243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000069">
        <property type="protein sequence ID" value="KAF5351507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FWP7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="188"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5351507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="646" mass="70242" checksum="0D6383397570B874" modified="2022-01-19" version="1">MVDSSQHFVSYAISWASIGLLYFCLISLLTFATFVLKLRGTSDFAQNLLDALTLPNAHCSFYPSSPGMGPRSYHHSRLELLNIVARRSSTTRNIYYLKSMESTPAPVETAVSQKPSVLPDDYDSRSNTIEVNGNGNSEVSHDHDLKPGHGESAIPADKKEEVIENEEDDWENDPINARNWSARKKWLAVSVVSAYTFIPPLASSIMAPSLPLIAEQYDIQNQTIVALTLSIFLLSFAFGPLVLAPLSEMYGRTWVLHLGNIFSLGFALGCAFAPNTGTLLAFRFLIGFSGSAPIACGGGSISDLFSENDRALAMSLYTLGPLLAPAIGPIAGGFLAESVGVKYVFIIIAAYCGVASAFGIPTLRETYAPVLRMRRAKKNAADPEKATKFQNPMVQMGKARYIRLNLIRPVQLLTGSFICFVLSLYMAFIYAIYYLMFATFADLFNEVYGLPIGTGGLVYLGLGAGFVASTFFGADTADRIYKNLIAKNGGKAKPEMRIPALFVGSLCVPVGLFWYGWSAAARVHYIMPIIGSGIFGFGMMAVFLPAQLYLVDSFTYAASALAAASVLRCLLGFAFPLFAKQMFDAMGIGPGNSLLGGNVSILRRTYSRATTNNESSSGLAIFLGVPFPIWIYYKGEQMRARSSFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0D6</accession>
    <name>A0A8H5G0D6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0D6"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="221"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="453" mass="46898" checksum="8D4C440355E83B0A" modified="2022-01-19" version="1">MPMPASKSSVSGGPAPATASVSGALPTANPPSTAPSASGSGAPAASTSTASSGGLSGTSSFNATASSTAPASSRGLFGASSSNPPATSNGPVQSGGLFGASSTNASATPTGTPLSAFGSATSNGPVQSGGLFGASSTNASATPTGTPLSTFGSATCISPQGFAFGLGSSSVGAAKSSTFGGSTWAPASGPFFTTSSNSTSSSPRELSKLFGSAKRHYWEFVVFQVEGLYFKVPRYHFEKSSEIFCDIFLASQGNTPAKGSSRENPIKLDGVQAVDFERFMEFLYPSTIPWREESRTDDDWKSILKLATLWRFIDLRKLAIDKLTGSQRMTSAEKILLGRQCSVTQWVRSGYIELIMQTDVPSMEILKSIGFDAALRVFRAREDARKLVSNPCACGRAPAVGSPDESKVQLSVDIGFAVELLDVSRKGAGYQEDHLQNGKRSELGPSSSSQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G0I4</accession>
    <name>A0A8H5G0I4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_006293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G0I4"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5355453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56560" checksum="6942246979E86678" modified="2022-01-19" version="1">MTHDVETYCNKEDIKVIERFFDLPLDHANPSGEKIRVFARNLIPRKKAKTQKEEEELPYLVYLQGGPGFEVGLMGSSGFAGEIHEQGYQIPVKGMVLQDPCVALRIRFVFWSHNPLLTLLAAVGCILQTLWLDPRGTGLSTPITPDTLPSRLKTDQDIADYFKFFRADSIVNDCEVIRKILLGNKEKEEDRKWTIMGQSFGGFCSITYLSFHSEGLKDVFITGGLAPLGDHPDPNYEWTVRKVIRRNEVYYQKYPRDKKRIRDICTFLDGNEVILPSGGRLSVRRFQQLGIDFGMQGGIDRVHQMVLRASNDLELFGKISYKALQTIENSQSFDGNPIYAILHEPLYCQGKSSRWSAHRVVQKHPQYFSWNHIKDLADTEPIYFTGEMIFPEMFDDYKNLRPLKGAAEILARDDSWGPLYDLDQLSRNEVHVTTATYYNDMYVPFELSQETASKIKNTEQYITNQLEHSGIREDPKDLMKRLFRLAKRECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G172</accession>
    <name>A0A8H5G172_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000055">
        <property type="protein sequence ID" value="KAF5356447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G172"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5356447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="625" mass="68962" checksum="FD1806DA1E156A8C" modified="2022-01-19" version="1">MSFVPLSVSPATLPVDFLHQNGEDALYQYVDLDIADGTLLCKLSRAYPLLPVSRIYASALCATVFWITGQNSGALGLLSDAHQLVYYDIDSDTTPRDLTQTLSSFSFNPKNFGALSYRIAITFGPATEECQHLDVTNETADWNDTNRKSLEFSSIGDMFWHWADKIPGAMAVENSDGSLSLTYHQLDQWSGVLASWLVAQGHGGEKETIIGVWQIRSAMLVVTYLACLKAGCAYLPIKMNLPSERVRAMLTISGCGLVLGYGTPYDFPCKDVVQYMDLATSDMQQVLLHTLTTSAYLPSVTISRLSSLIFTSGSTGVPKAVMIQHICLLNFLVSEYKPLNQGDRVAMILNIAFDVSSGEIWYPLAHGATLICHMRPYNAPFDVKDLSSFLEEKAINSFDSSTAVLRSLVEARFFEKELPSLRSVGLAGEAVFLAYIGPILNAKPNIILINNYGPSECTIYATTFTIPSSYNQANVAIGRTMKNIGAYVVDSDFKPVPLGVCGELLLTGKSLARGYMNREDLTSERFIWLGEDHYFGNLRAYRTGDLVHQTASGELEFIRRVEQGQVKLRGYRVELGEVERSIEQHPLVKAAVAVVCHHGESDDRLIAYFTADGNELQEFPEALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G3A0</accession>
    <name>A0A8H5G3A0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000051">
        <property type="protein sequence ID" value="KAF5357513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G3A0"/>
    <dbReference type="OrthoDB" id="3253683at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5357513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="384" mass="43602" checksum="0271C2C8AB989E13" modified="2022-01-19" version="1">MSENPATATAGGTQAPHDAALPDDDAQSSTFPNMTTKERGVKPEKFTGDRNQTKDWMAEFNNYLRLNDQVYPTEDEKISFFLTLFSGDEAKRWARNMMAKVFEEEDDFSDSDEEYTSTDEDSSASKTKKKSWTLHEMKREFLRDFKPSARETQAQTKIEHIKMEGALADIDKYNSQFKRYADDTGYNDKALMKYYRKGLPRGLVDRISYLSTQPRNLAALQKAAVKQHMIWLERQEEKTSWSKPQREEGQLGRASQGTRSGRARSMEVNAFQDNVPGASSITKYPPKLTPQEREKMKKEGRCFRCRGQGHMGNDCPTFPSTPPTIPNNMTWRPSIKKTAVGTETSDPKVDATTDNISELTARIGALSGEEKEGLLKKFVTESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5J1</accession>
    <name>A0A8H5G5J1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5J1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5358667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47233" checksum="849357957FA27C9F" modified="2022-01-19" version="1">MRVYVVGDRLDSIFMLSLANQGQYYQVFLSQGLALAIGSGLIYIPSSSVVSHHFQQRRALAMGFITTGSAIGGFFFSTIFSHFLDPGSTDTIGFAWGVRIGGFISLVCLVLANFLMKTNYPPTARLGPTSIQPKRFTNGTQLPGVGSSTSSSSVSSSSHSHRSKTQSQSQAEPKPKPRPGTLAFILSLLLNPSYSLNLFIAFLVGLASYVPLFSIELFASTPPQSESISPSIRPWLLGIMNLSSVLGRVFPGLIVDLVNTRASVQRNGNGIGAQNVIFIVFGICMGVSGVVALMMPLCTNTATIVVFCVLYGGFQGSATALFIPSVISLTKDMSTAGVSIGVATVPLGIALLVGTPIAGAVVQRPKSLDSNPDWWAGSVKEVEEGGEAEGKAERDKEMAEHESGHGEGRESEGSGEAGTGARWFKRYREGVDSGREGFEMEGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G899</accession>
    <name>A0A8H5G899_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_011336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000044">
        <property type="protein sequence ID" value="KAF5360183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G899"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="193"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="359" mass="40826" checksum="58C201B747F331B6" modified="2022-01-19" version="1">MFQSQFDHLEKLEDIENAIHFNQQAVDLTPDGYAYKPFMLSNLGSAFQSRFEHLRELGDNKNTIHFYQQALDLMPDGHVNNASQLINLNLSILGNWTASSRHLQLSRKLQKILPAHLQSNTMLLINGKPYPQNIRTPLQHLMHTKWFSKFFHSLFGLDRLSTIVMMNQPKSASKVYLELKLRRRPYRNTHYPRIAASDEAIVKTVKNEMSEHDIVHLACHGIQDPKNPLDSAFVLHDGRLKLQDLMHLSLENAELAFLSACQTAAGDQNLPEEAVHLAAGMLAVRYPSVIATMWSIGDNDAPIVADKVYKSVMGCGNEVVTQNQRQSAVYALHDAVEYLRKEIGEMNFVKWVPFVHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GD52</accession>
    <name>A0A8H5GD52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000038">
        <property type="protein sequence ID" value="KAF5362621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GD52"/>
    <dbReference type="OrthoDB" id="2129641at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034554173" evidence="1">
        <location>
            <begin position="22"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5362621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="652" mass="68871" checksum="1BE099D42CC5494B" modified="2022-01-19" version="1">MRIHSPSFLLLFVGFLCNCFAAITQVPYDPSPFTTTGYITGATINNQSDILSGGTITLNGNIEIVIPRNLLVNTPSLTAVAWSEMFTSNGDINLPLWPEVSWEAFIYANYIGGRHVAGIVYILQEIGNLNEGFITSIDYEKGEMRINGDFNDPTSGIRLVINDPVGRYGMVHGDWPLWTADTDNPSITASTGYPVCLPRVDPATGDDPLCPKKNRPLDTNGNPLTIFTFPAPPVPEGQPDPNLFAPLMVGDFIVYSATLVEDQNGDRLLAAYSINVNLGFYTAPGTIPAYLIIVEPQVGINGDPRGEIEETRVEGFTTDQTATILVSTIDKDPCTGEEKDRSWGSAIPRAAAVQGNYRFRSDDVASLAPFTREVVVQIARGTVDTPNGITAGRFVSPQPPDGWLFPELLVFGDDEIPSQFDLLPFLAAGSGPWLGGIPGVPQTATGPIVGQLDPWPGVAVVTPRNCPAVDPSIPVAQAGEDLTVASNGLVTLIGTNTKEGLSSDNLTFTWTQLSGPTVSLNSTGNGTVTFVAPAVSSITNLIFQLTVANSAGNSTDTVMVNIVPVVIDHITLDLVSWKSGKGSGTLTVIATTDVASAMLFVSATNPDVATIAMTSLGAGRFQALVSMRPAPASVTVTSNLGGFAATSTIAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDC2</accession>
    <name>A0A8H5GDC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_007084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000036">
        <property type="protein sequence ID" value="KAF5362847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDC2"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5362847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29724" checksum="75B1C400BDA2327F" modified="2022-01-19" version="1">MSSLDLKGKIALVTGGGTGIGLMIANEFSKNGAKVYITGRRLDVLQKTAAEAGLVPLQMDVSDKQSIANAVKIIDQDEGKLDILVNNAGVLGPNFPIITNKPTTNDAAVFGSTLFTEGSFDQWTDVLQTNIIAPYFVIMGFLPLLERGARTREGETSSVINISSSAAFSKLTGGFSVYGISKSALHHLTSIWATEFALHKIPVRVNCIAPGPFPSELTGTRDDMAEWITEPLPGLFNPVPTLRPGTQIEIGAAAVVLSSRAGEFINGIIMPVDGGISLVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDK0</accession>
    <name>A0A8H5GDK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000037">
        <property type="protein sequence ID" value="KAF5362770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDK0"/>
    <dbReference type="OrthoDB" id="2871083at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5362770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="271" mass="29967" checksum="5ED4E4C7F9C9A732" modified="2022-01-19" version="1">MKRPSSSSFELWEQLEDMSDAMEEISLSEAATEPRPSCIPRLFDSQSSETRKHFKVKKWYNVYTGNTPGCYTTWADASARTQEIPGARHEAFKKYEDALHAWRQNCLAVHVHDQGFVDGTVLKGLAPVLEGTSPTSPEPPRACTPPPYQSTFRYASDGKYFTPPSSPATGPLQASSTQSPSKRRVGQAMFGPGSPARLPERHSQVNPVRYWAISVNGQKTIATTVDHADDIVEEAQLRGVDAVIKQVASVREAEEWFALLETATDESQHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GDS2</accession>
    <name>A0A8H5GDS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_012660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GDS2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034308067" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5363063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="367" mass="41376" checksum="352249B4840ED985" modified="2022-01-19" version="1">MFSKILALLFVATGATQVQASPIQSQVDVVLPRTDAPPPFNPSLFKDINVSRGLEYHYYAAPADSGKPTLLFLHGFPSSFYDWRHQVSFFQDKGYGLIVPDMLGYGGTAKPLDLEAYASSLISKDIVDILDAEKIDQAIVVGHDWGSKIAARLANYFPERFHAFGFLDVGYVAPIIFAAPFNDTMAVSKAFLGYENFGFFDYLARDGTDQDIVDHTESFWDIWYINDTVESITEFSPFGALEAFLKNDTRVATGDFVTPEERAFQTEFYNQNGWTAPLNWYRIITGDVDREDNKGIPQENTLLQKPVFFGSASRDYYSLSALWFEFTITSMGSNGTLTTREYNSGHWVQMQAKDEVNKDLLQWIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GE80</accession>
    <name>A0A8H5GE80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_008369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000034">
        <property type="protein sequence ID" value="KAF5363145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GE80"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034412108" description="Aromatic compound dioxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26781" checksum="66C2780169B1EB16" modified="2022-01-19" version="1">MRFAASVICAAVLAGIASAAPLRVERRDCSAEIAAYNLARREARGTDVSKRSMYPTMPNEVCVLAPEIQRQNWVQMSSSLVRQDITEGQAGVSMILDIGVLDITTCQPIEGALVEVWHPNQVGNYGNTFLRGAFQSGSNGIVEFNTIFPGYASDGANHINLSVHVGGTMSSGVSHNGQVFFTDPWTSVVGQSAGYNANTHKRVMNNNDPNYVAANSKGYSAIVDVESIQDDWPAGVVGYITVGINPNKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHK7</accession>
    <name>A0A8H5GHK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000030">
        <property type="protein sequence ID" value="KAF5364968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHK7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="7144" checksum="2D24D4FA325F554F" modified="2022-01-19" version="1">MTEPSTSLVPELLSALVLDNPARTFLQVASYCCEWAEISRLLLLVGTWEVMVLVTAHNVVIVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GHV6</accession>
    <name>A0A8H5GHV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D9758_005353</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GHV6"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF5365278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="811" mass="90750" checksum="A5426D330EE7C251" modified="2022-01-19" version="1">MFARQTVVRAVARPSLLATPPQARNMATLRELELRLKSVRNIEKITKSMKMIASTKLAKAQRAMQAGKQYGEANAEVFETVKEEATSGGRKLFLVISSDKGLCGGIHSSVTKATRRAIANDKESPLPGTKVEADSPVMVVGDKSKAQLSRALGGNLVLSFNQIGRDVPTFADAAGVADLVIKSGVEYDSVVLVYNKFVSALSYESTAQVIKGENLLKDTEGFKKYEMEDDVTRDLFEFTLANALYAALVEGHACEISARRNAMDNASKNANDMIGTLTMQYNRGRQAAITNELVDIITGASALALEEQQLELKTPITYALLGVSVTLFTAKIIRVRTEQAKLDAIPTIGPQGFFGSYLGAIKYLSNGRDMVEEGYRKYPGGAFKIPLIAGWLVFVNGRDMLEDIKAADDEMSFTDAILENLQTDYTMGKQLRTHPYHVDVVRNALTRNIAARLEDVKQEIVDSFEDELPAKEEWTKVYALPTVMKIVARTTNRLFVGLPLCRVTEWKDMNINFTIKVFLASQIINLFPAFLRPVVGRLLTPLPSTTRMARRYLEPMVKERLAKEEEYGDQDWPGKPNDLLSWLLEEAKLPEQRTAYDLAQRIIAINVAAIHTTSMAFTNTLFHLCARPDIVKELREEVENTVKEYGWTKIAMGKMRKLDSFCKETQRVSGTGAAVVFRKALKYFRFSNGTVLPAGTMVASAGYSMHHDERYYHNASEMDPFRFSDMRGRDGENLKHQMVTPRPEYVLFGGGRHACPGRFFAVNELKLLVSHVLVTFDVAFEPGKDPAPLYEWYADMCVPNRNIIVMFRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GI50</accession>
    <name>A0A8H5GI50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_005409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GI50"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748273" description="Cutinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5365231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="203" mass="20767" checksum="21CDC1B736F89687" modified="2022-01-19" version="1">MFKSLLPFVTVIGLVASGLAAPVEELERRQSCADVIVIYARGTTQQSPIGDPASVGALLKDDLATALGSRSLSFRGVDYPASIAGFLEGGDPAGSRQMAADITSAASSCPNAKIVSSGYSQGGQLVHNSAAMLSASVLARINAVVIFGDPKRDQAISGISASEIDIICHDGDNICDGGIIIAAPHLNYQNDAPAAAQFIASHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIE1</accession>
    <name>A0A8H5GIE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIE1"/>
    <dbReference type="OrthoDB" id="2678913at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15716" checksum="936D45FA27B5FC60" modified="2022-01-19" version="1">MSEEKCTPASPNIITLWLSTIAGTYSSATIKNYLYGVRAWHIIHGISWQIDEAGTDALLQAVTRLAPESSKRKKRLPYTISFITTLLEDLNPNKPLDTAVAGCLTTTFYGRARLGEFTVPRLTDFNPLDFITRSDIHIGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKP3</accession>
    <name>A0A8H5GKP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKP3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36278" checksum="3BB22EE097305C5F" modified="2022-01-19" version="1">MNGHNQVEDLHEESGVGDVDEEDIPSYFIERDGRLYHADPRSPYPLPCDGREIQRLDTQHSLLREINGHNYIFPDIVQGVLAPDVEGKIVVDFAHGTGRWTMEMGEEFPHVQFYGLEIVPITNRDHLDNVQFELDSEISQGTRFENASITMVHARTTYMTVRNYYQSIIIEAARILRRRGLFLAGEWAVYPTFVENAPHPDPAQMALVQYFTILTNCLTTRGITPVAHNLAGLVASSNLFAVHHRDTWVPIGPWDPARQTFGNRMRTILRRFMSSTKPLLLQASGMTSEQIDQLFAVCNTEMVSTPGLALIFHSICAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GKS8</accession>
    <name>A0A8H5GKS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_008962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000022">
        <property type="protein sequence ID" value="KAF5366540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GKS8"/>
    <dbReference type="OrthoDB" id="5083627at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5366540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="567" mass="62937" checksum="7DE1597F8F63FC8A" modified="2022-01-19" version="1">MSTSSEMETYLKALRRDGITQNWDVVVTYDEASINDLLLQRYNEPNTGLSTKVEPSFVTTDRDDIEYTQYYSLDLGPPLIQFQDTPNEPTCDLTMPILSGRIWRVDTADGKVHPTTELKGGIYSIIIAKISLGTISGETEAGDIKHGNDIVEFPLDKISDEQIVINFPASGTLDYRITYPSDMPGNDIPWAMHENNLLVALCTYFPATVKAIHYALAGINNQPPASGVVDLIPHTFRIVTYKDNDTNPAKSYLSVLIQTRGSTVRGNTKQLQSSWNAQWVAANVNPVPVGKSASIIINNAFFVTSFITPTLKGSNQITDVVPEALKPDESGLQVKCTWNKSVKTDSKHFKDKINDPYDEPKLTKVDVPALDYNPNDPRGLPLRITFGQAQGLDKPATILLEWKYSFHQTWTGVMSCHVVLNADDWRGDERVMPKNTPVKGGFTATFTLNKVFDIKPLTQEDLNVSIDFNKDDWKVEVKPDEAGNLRQRLGATFGGTEQVGYLPNFIKDSAIEGIGFNFNFGTLRFFSITNVFLPGRKVIDVDHKTGLRIPRDLIIVGNVVPSTSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLC6</accession>
    <name>A0A8H5GLC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLC6"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5367123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="187" mass="20574" checksum="9D22A41C5576F184" modified="2022-01-19" version="1">MSNTNETSPPIPSQELLDRNVKYAEGHKAKIGAENWGHFPKTAIITCMDCRLHPQKQLGLGDFDTTIIRNAGGGAGELTRSILITQKFGTRHFVVIKHSDCGYFHISKDAIIEDFKAHAKDPNAIDAVADKIPTNFGQLSVDNLALRDVEYLRKSPLIYPETKVTGWVFDDNTGKASLNSCLCSGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GLU4</accession>
    <name>A0A8H5GLU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_004060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GLU4"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5367151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="500" mass="54628" checksum="EB07E7A4230240B5" modified="2022-01-19" version="1">MRPMKLAVVGGGPSAFYVASRILSLLPKDNVNIHIYDRLWAPHGLVRYGVAPDHPEVKNCVHKFDEAARDPRLKFFGNINIGIKPSTTVPRSLHLPLSALLSNYTHLLFASGCTLPTLHPALLPSSYCIPALSLVHWYTQHPSQPPPPPLEHVHHVSVIGAGNVSLDVARMLLCPPSHLQSYDVPQSVMSVLSRSAVKHVSIIARRGPLEAAFTTKELRELMSLPNASMRPINPSLLEAPPGVKLSRQQSRMMDVLKKGSQNAWGTTPRTWSLDFFRSPTGLALPPPESPRNAPAELTLAHTTLAPDPDNPSVMRAVPTGETSTLSTSLVVTSLGFKADPTPFPDLYDPKSAHLRVHAGRVLTASGKPLKNVYSSGWAAMGAKGVLAATMMDAYAVADVVLSDLMDTGGDVRTMAVTPNTESDGELEMQEIGDEVLKLSAEPPDMEKPPEEVINGVEEKKVVTYDDWKKIEAEEVKRGDKAGKERERMEWDEVHQFLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GML1</accession>
    <name>A0A8H5GML1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_003762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000019">
        <property type="protein sequence ID" value="KAF5367510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GML1"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="380"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5367510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="533" mass="58708" checksum="0255FD85D38B034D" modified="2022-01-19" version="1">MAEIYSSLSLSPKKRRVSRSPESDDNIYSPKKLRTAPPTPPVTPSKNKDSSTEELPSHLTRLEGIQTALQQALSHALATCAVSPSETGVVRNVLNHVSLNTYAGLSIAFTVDDLRRLCWIWEWDGKSPAKIEDDDDEENPFVNPTTSSKIKDWTRGGMSMVITPTTHLLKAEGKRVPAYGLGIEVEVDLDKDQESGMAAVARWTAAAETRRIQFHEKLISWTKMYSNPIPRIPLADLPALSLPMKSAASKTRTMPVSIFPPTPSSNASPTKRSQISLDALRSTSRPSSSTKNSIPFPSTPSSRSERLAQLLTPRTPRISTSSNVSVQDTPSGDATPRGRTSSSASQTPTTARREALYERIRQRSLSASPTKNRRITGLDSDQTLSKDQVLKLEQEETRKRFLLGRLGNVAESVWMLFSTPATGTSSLPTSRKRRALARPEVTKAIVKSSAVPISSAEASESLDMLTNLCPFFLKPLEVAGKDWLEMPASTLRDSNEQPADSQKKRGRKPAKQEAKGLKEVKEIIQRELELRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQN9</accession>
    <name>A0A8H5GQN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQN9"/>
    <dbReference type="OrthoDB" id="3221808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1007" mass="114332" checksum="610E5C1039011004" modified="2022-01-19" version="1">MENGLSADSRPALSVESSHSLHTFDDTSTSSLPPPGPDNDKKPSQKRFQPTADDQACAGMWSIYIGEAERYDKSLVEGWKGDMEGMVIFSALYSASLTAFLIESYKTLQPDPAQDTVFLLSKISQQLSNLTVPPSEPPSFETPASAILYSCSSGPEISSIRQNLRPSPIRQARVFVYIYFGLRDFGMHSFVDIIPFLLHLSLFLFFGGLVAFLSPVNRIITYIMIGVLGVFLLIYTALTVIPLVWLNAPYRTPLSGALWRLGNAFGSFLARKHDLDHCQDATLSEALLEKSLQGTSERDRQALVFTMQSLTDDNELLPMIGAIQDVLYYDSRYGFKIREANVDLIMPLIMSDDPEVNIISRITQYLKRSQVVPALKDSPLHGQGSMPPVYSLVYTLVYTLMYMLTHLAFTEDLLWHIAGVSGHHKSLSSTLALLRFRWISCIRDVVALISRNLDEMKKANGQNIPASALRGQISHMNKIWESLDEKRMVYILVSANPIYGVMPGFHRLPRTLKEAGEALKKWGMSVEHSREPCPATVPEELEAALAKLKQDDTWAVTCSTILFEYLQQVLTWEQSNQTSISELPPDFERIWDIICPPHPSLYLVDLPMKPGDNYMYPLRTLSKWLLDQSTAIDDKVDLWMEKYMQLFFSVKEAQSNPILAIWGRNLFLQYFSRRAKEAVAKPPHDLGWINRFISYQSDSRRLVGECVIQNIRHETTPESLTCEAAFLFSLLCQIYSSSALSELWKILDDSDKTSSTQNTDILFLRITLSLINIHRISWPSHIREKWQSMEVTLLPRYLSDELISSLSRETLRLSLWVALYTEWLDQLAQNRPFAQLDLCNLFHMSQIRFPSGTTDLEVNEKLQIRFAKIYSNFIKAMISELEDAGSDKYLGRVHPSVYGFFAKNDPWPSRVEPLPDVFVWDWITNRECAKTIMQAIQKYNRGEEIEGQSTLFARCLEVRGQLPASDSDLDLDSEDVQGEGDETAEKCIVSLHEDVGIWVGGHPSPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRM0</accession>
    <name>A0A8H5GRM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRM0"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5369919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="179" mass="20534" checksum="C9163759F766311E" modified="2022-01-19" version="1">MASPSKRRIETDVMKMLMSDYEVSLVNDSMQEFYVRFHGPEETPFANGVWKIHVELPDQYPFKSPSIGFMNKIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPNDPLNGEAAALLMRHPKEYEAKVKEYVQRFATKEAADAATEDKAEDEDEEMSDIGSISEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRS2</accession>
    <name>A0A8H5GRS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRS2"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5369808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="28993" checksum="FDB76E2C4923EBFF" modified="2022-01-19" version="1">MHKTRSGRDLPLIHSHLPCLTVIRVKRSVLARNAQNVTEPLWHTFSYLNVECQTEDWKVHKRTVCVKGEIWNKTERTLRKISGPNNPMGRLQSMEDNAWAFRRQNPDPNPSHCDGCFRRFRGHPPNEDDIDETGKPYEDCGSVSDGKRCRNCDWVACRDCMRPENQKWSVLAPPTGTCRCLKSNFGVRYCTLTTSYLHGDQKKHYHGDRHPEVSASGYSRSAFEDEPRKCGNCGKVALCLKGEHLKDLSPLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GRU4</accession>
    <name>A0A8H5GRU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RPS1</name>
        <name evidence="17" type="ORF">D9758_001127</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GRU4"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11 14 15" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="16">
        <location>
            <begin position="315"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="14">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5370051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="454" mass="50796" checksum="20B13BB2ADD70A6A" modified="2022-01-19" version="1">MAVGKNKRLSKGKKGIKKKVVDPFSRKDWYDIKAPSIFETRNVGKTIVNRSTGLKNANDSLKGRVIELSLADLNKDEEQSFRKIKLRIDEVQGKNCLTNFHGMDFTSDKLRSLVRKWQTLIEAHVDVKTTDGYLLRLFAIGFTKRRPSQVRKTTYAQTSQIREIRKKMFEIMTREATNCDLKELVQKFVPEAIGREIEKASRSIYPLQNVYIRKAKILKSPKFDVTKLLELHGETTDETGTRVAKDFKEPEILESYGISDEADNFALALPIMADVEYLRGKLTAHPDFPKKGIVFLDIFPILRDPIALETLITHLIHHLTSHTIPNSPDKKIDVVVGLDARGFLLGPIVALRLGAAFVPVRKKGKLPGECASASYEKEYGSDTFEMQADAIKPGQSVVVIDDLIATGGSAKAAGELISKLGGKTLEYLFIIELMFLKGGSKLDAPVYSIIQSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSV1</accession>
    <name>A0A8H5GSV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_006920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSV1"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="292"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5370393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="839" mass="88311" checksum="2FB981355A06C965" modified="2022-01-19" version="1">MLVDNPIQQNPFTNNYNDISDFFHTELFAPSSMTNPVSSTTPGSPGASGSASTSSRASSPEESLSHFLSTPPQEPPQTTFPDVASQDPFSFLSSGPSSSNFGFGLGGSSFFNFLDEELKMDQSLGGAASAAPYDFLSTPMASGSSDVDLNALSALFQPAGNATASSSMMAIDPQLVDTPAASEAGHDETEMAADAVKKTEPTEEKLTLTIAPVKVGGHGKARKGTVQGGGITKKVSSIPSAPASASVPAPAPAAPSSKNKENRTSPKSVDDDDDDDDLPADWRPPPEVFAKMTSKEKRQLRNKISARNFRVRRKEYITTLETDIAERDKLLQAIRSELGSTRSENLALRQEITALKRALLDGRSGASPSSPGSLLTPTSSPSASIRGIDINLNSTAVSIDDLASLQGLNLPPPAPLPERSAAEELAARASASSSPATSSTSHNLLAPNIHKDLPTSPRLGGSSFWGGVSQAGFGLGGMGGGYTPVHRVLMPDLSVSQWVKDVVAANAAAAALNSPPANPALQENMNPMLNQSHSPPSSPEIKQEPSFEGFADSNLFTMKTLDAYRMQLWTKMAAQQQQQHHHHHVHAQQPQQPQHQHQHQQREFSPSPFTLPSHQPQSGHPHLNGLASSLKPAYFVNSNKPNLSSSSSSSRPIMGSTLSALLAGKHSGSSSSSHSYSWSPSNAASAYPSPPSSPNLSGKKPTSSSSSSTISQAQATQMQQQMYAAAIATTASQTLLSKLGSAFWDAFSGGSSASTTSSSSSSPKLWDADKVRKVLEGKAVVRVVDVDPVPVPVSSSSLQAEKDKVKGPMPTQTQMQECSCHVTSLLEESMRSLTLSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GTA1</accession>
    <name>A0A8H5GTA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_002087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GTA1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5370574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="451" mass="49268" checksum="CD4191629A1DCA6A" modified="2022-01-19" version="1">MPGPDRNSRSSPSEPEVKIPRPPNAWILFRSDMLRKINPHTWDANGRPTRKTQAVVSKEVADLWKTASPDVRAEYERRADAKKAEHSIQFPNYRFTPLKKEDRMKLKEEKKLLKEQERANKRRARAAPYTPSPMLPPPLPSGTPVPSYPLAAPSPFPYPFALEASPPYSAYASPEVVATVEETVSQTQEAHSQTLGGASLPLLGVGSSSSSTQDNGLMLSTETKQPVAGPSHFHDQDQVSWPGDSSQQPVDPGFVHFDIPDQQWLGPNHHMNAICSTTADPSVYQLAFDQHFLDGAPLELSLTGSLDPNFFPDMRHLDFSSLLDGVDNNFDFFGNGNNADPVITGALGSEYQTQSYNAEEYLNFEQDQPTSSSSSSTQFSTPDPSQSSVSNSTPNTVASTPNPVPTPSYTPPTGAAFSSQRRVAGTWSRSFAVEDTSSPQSQPAQIPTPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GVD9</accession>
    <name>A0A8H5GVD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_003593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000007">
        <property type="protein sequence ID" value="KAF5371627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GVD9"/>
    <dbReference type="OrthoDB" id="3234968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034209694" evidence="3">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5371627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="414" mass="44849" checksum="38C708B0807901B4" modified="2022-01-19" version="1">MKTLPLPLVLLLAICRPSLGILNNVTLEETSSRIIYGTGQTGWAKLHHDSLYHNNSHAVSSDPAATATLTFRGVAVYYYSSFWSHNVSTTLQLDGQEKIILDLIDASEFNGTAGIKTTKRSDIVWSRTDLPDEEHTLVVSCPTEFGGSVLMDAIMYTENKTDDQPVSPLVNHTVESQQFDYVEGAWSKNSSDPNLFVSDLIFSSQDDSSKAVLTFTGVAVYYLAARWPLKTVTTLQLDGESPEFVDLTDNAATDAISAPSVESTVGTYAIVDAIIYTEDISSSPQGPSPQPETDGPPSHNNHSVAIGGIIGGIFGGLVAVAVILVLCHRRWRQIRRRELHEPGTVVSFMAGVENTHSISGAATSTSSSEDMRAETAQDYAKNLRRKGVLSSFRVVRNMGSRGAPETLPPPPYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GWB5</accession>
    <name>A0A8H5GWB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000006">
        <property type="protein sequence ID" value="KAF5372100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GWB5"/>
    <dbReference type="OrthoDB" id="5552562at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF7">
        <property type="entry name" value="RETROTRANSPOSON GAG-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="793" mass="87872" checksum="F3A12CA523CCC980" modified="2022-01-19" version="1">MLPQQSTILTDSIPCLPYTSFSETTGSAQTYLLLSTMSQRSQPRTPSPTPNLTVPVTPFKNTYYSNLFHNIQIRQHRRSGSIFAHPSPTKPCTSPFKEFLDSWDSPEPGDSGTLTQTQSRSYVQQQTQGSSRAGPSRTPANPDDGCGPPPGQHYGQGDDRDDNEQHQGGGGGRSDDGGRGPPDDGPPGDGGSDSSDSNNDDDDKRRQFITTLQNFNEIIGKVTPGHSEKTEVKKPDVFDGLDPKMLCPFLIQIQINLQNRPKAYTTDAAKISFTLSYLSGTALEFFELEILNPDPEEPAPWTLDFGIFVKELKDNFGVFDEVGDAEDQLEALFMKDSDQATKYCAKFQQLASQVAWDENSLRHFFRKGLAPQIKDALALVYEETNLPHLKSQVLRINSCYWRRQTEEKREEGSGGKGNSRGKGSGGNSSGSGSGKSSNSGKVPKIVSDSDASARGRSCVDQDRANQEVTLNAAALSIKSLQIWHVQQPCLHSRPLLILHFGNSAIASRTFPIWMRRWSWANCMAQRVETSGRTAVRPVKLHPTRDAAQDSQARFPSPWDVHSKPSQVHQEHRYTKSRSKSEDKEKTEKTNVPQHMPLPSPPQPLPHSPSLHPQIPRPYVASEPHEDYSVRDSLFSSLSPSLMGPHWNAPFPPLDSVLSVPSPSLPIPPAISPPQPPIPPSSSFPRLSAAPTTTPSTPPQPRIPPSELHMLVELKLILLASVENPIQNRLRTIFIFLTDPMLFRHPHTIIDHFFHQRFGMHRSRRFRVGRCPFGHILRQELGNVKGNVGSGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GX04</accession>
    <name>A0A8H5GX04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GX04"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5372524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="441" mass="48269" checksum="DF63D53FD80635F2" modified="2022-01-19" version="1">MGGTPTIFVAINYRLGPLGFPRGDDVAQEVTAGSRKVLNLGLQDNIAALQWIKKHIASFGGDPSKVQVVPRVTIFGESAGARAIEVLLLSNQIQGLARGAIMESTGGASPISPTSDTANTVWDDFMAALPQCANTSMTDVECIRQLNSSEVIEGFINGNIFFNSPARGNWQPTLDDDIIPRFPSTLKPDHGLLEAVMIGSNKDEGTLYTDQTVNSPEVISAIILGSPPSPPNATPFQRQVQLQRLQRILKETLVLYPNIPSLGSPFDTGNETFGLDPEYKRTAAVSNDLIFESERRFHINKQLLPAGISTFSYLFADPDAVPVQDFVIGTPVPGSLGVLLKVTHSSEIFYVFGTLADRPEVNEVTPTAAKLSEMMMDYWISFANTLNPNDGKGSTRPNWPKYTAIRQQMMQLNGHNTTVIKDDFRKRQIALFNRDPTVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GYT1</accession>
    <name>A0A8H5GYT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">COA8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GYT1"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="22031" checksum="20250A027D369959" modified="2022-01-19" version="1">MTSPSRAARLIVQGHVMLSLLQPRRIQRPLHRLLHASRILSKTLVGPPDPISHLRPVIYDDVLAPPSPSVLYHPYSLAEFDPEPKRSQSQNELYYKLQMQRLDALSQNFWLDSNSRFEAAKEAVLNGLPSSATQLDKERALSEFYKQWLMQERSRLDKYTDSWRKENVACIILSARVQWQKFISVITFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ16</accession>
    <name>A0A8H5GZ16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_000891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ16"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5373906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="208" mass="21747" checksum="DF96D0EAEB78938F" modified="2022-01-19" version="1">MSSIKGAQSQKLDGSSLRIAIVHARWNKVVIDALLAGTIAKLKESGVKESNIVVESVPGSFELPLACSRVIAGSHIQIATNQTDLLGGLNFSPSGAASPMRSGTPAPLPPVNQPFDAVIAIGVLIKGSTMHFEYICDAVSHSLMKIQVDTGVPVIFGVLTALTDDQALERAGIGKGANKGHNHGEDWGLAAVEMGSHCKRWAQGKFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZB9</accession>
    <name>A0A8H5GZB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D9758_000643</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZB9"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="18">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="215"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF5373769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="313" mass="34992" checksum="20A5FC2EBBEDFEB3" modified="2022-01-19" version="1">MPPKADINKAGWEQSEFPILCETFQARVRPILRYLCSPFTVFRWNPGSGSRFKTTVICQTCAKIKNVCQTCLLDLEYGLPTQVRDTALGYEGEAPTSDINREYYAQNMESKLEGNKSALDTGRAASAGKEMLKQLARTDPYYKRNRPKICSFFVKGECKRGNECPYRHEQPPNDELSHQNIQDRYHGRNDPVARKMLATNAESQGLKPPEDKSVTSLFLSSLSPNSTELSIRTRVLKSLPFLDANQLKSVVHVAKSRCAFINFTDRSSAERASEAWANGLEIDEQKVNVKWGRSRPASNAVPTASTSTVSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZP0</accession>
    <name>A0A8H5GZP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_000680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZP0"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="155"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5373785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48499" checksum="0CC1ABE0E99FE49B" modified="2022-01-19" version="1">MFTVPRLAFRRSPVLGRNCQPFRRTWSSFSLGDNALTIDAFNNTAFPYVWLRDSCQSPECVHPPTSQKLHQSSDIPLDVKPIIVQLIDESSPDPGLRIEWQDGHISSFQRSFLERYISQHNLAKYHKDLPIELWNEQTIASSPDLFLENEELETPQGMLKAINQLCRYGLVFIRAVPNAMTSFDKCGIRELVYRFGYPRETFYGLFWNVINTNSQNIAYTNLKLDLHMDLMSFESPPRYQILHCVRNRVEGGTSIFVDGFNAATQLRDMKKSAFDILASTLVPFKYIFDGHHLHHERPTIELDPFSPGRIKYINYAPPFQAPLHLSSPPEFYSALKSLDDLLHKPENMYSYQLEAGDAVIFDNRRILHARTAFQERNIRVDEEQPDKGVSRWLQGCYFESETMQSRGRVLRAKQEQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H109</accession>
    <name>A0A8H5H109_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H109"/>
    <dbReference type="OrthoDB" id="2537258at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="183" mass="20171" checksum="38F1D014E4DC2DDB" modified="2022-01-19" version="1">MNSPESLLASARNVLDQPPPPTLREILVAYRAKGDGDRDMLLAMLNAKTAEDQRIAQTASLHRALLEEHTSQSTILPPLTHYPSPPSTYNHPPRKRHRSSRSPYARPDSYRDTDRDSNAGLPPSPYSSRSSHSPDFSPRSQHRTSMAIGSLISASASSPSHSNLERPHESSNSQDRQRSPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H142</accession>
    <name>A0A8H5H142_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H142"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="173"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="876"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="951"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="994" mass="111706" checksum="617AB272755AB38F" modified="2022-01-19" version="1">MASSSNYARWIDLAGNELSVDSVEEILSHIPDDFWVAAACYDRLVDDVNVQRTLLQVGLTRTQPVFDRVNHLFPDTNANVNDTHALTEHFESNITDAQLCYIRSVLLKRMDRLNTFVELCKEAPEYLQRESGMDEEDAEWEDDPWAEEPSAKPPAKPPFSLSEFLTADLLHSAYQLAFERWFGALRVLFDRHGKYLWPFRFAILDQIPDYAPPSDYHPLLPSCNTLTNMEQSPTWNEWRLEPDWSESSMVTSALESCRDSWDLSIFQEAEIPEPPFHVDPLTGEQLSAWYQTRVDAIVSSTGMIDTVLTMVQHGASHGVPLLDELGEDLSLLSRLVYDTPRNSDAPDEDWTLARWRVMDPPAIVRAYLSRSSPTTLPRDISRLVMPYLFVLESRAERAGNPDPSLAQRLLHEYILGAPLEMAAAVFEASKPTLPPAQRLIKDDEVVVRLALSCLYGSNSLNEWSTMSRIFECLPAWDIPRADSEEDAADTTVASLGAYVTPSTARPTCTPSDLLIFFSPLPLSSLSRALDILDVHLESGEILSRWSVPAPLHWFLQSSNDAAEQRAWANRMSRRAGGAEDQLNALEDWEWLLEDMLKLNGRGDNKIAGAFGLLSRDEVLRIYFSGLLSTGKFDIAKTLLHSRKTQLVLDTEIIEDICLSSSREFYDNANSGNYNFGDMKLAYECLDVPIPSDRIQKEKEFIEATSRLSSFNVMSRPGIPISPIEIRLTKDRLSLISRVLSSNSDAYKHTEVILDLVHKLGFRNDIVAEVKALAMLADSALQAEDFTRAYDTCRRMTDTVLSLRMSDMGSDNPQVAEASEVCWVACFQLGRQSEFDVTNQKLSLLGRAIEICPPDRLNDVLTAWRRLEKEDIQAREERLHDRRNGAVETDHQKHAKRLPETAADSLQARLRNFHMPSPPLLSTPDAAALASKTFRSVTANFPFSVGSHRGRSQLSQQGEDQSSVSSRGAEEDVSAQASRVFSKGIGWLIGADENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1L3</accession>
    <name>A0A8H5H1L3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_000249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1L3"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5375043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44172" checksum="3ACE179493C748AA" modified="2022-01-19" version="1">MFRRTMSTKVPRGLSAILSKNPDDVVITFAKRTPIGRAKKGQLKDYPVDELMHALFTETLKRTKIDPAKIDDICVGTCHPPSPLYVSRAAALAAGIPHTVPISTVNRLCSSGLMSIRNVAHAIQSGETTLGIAVGVDSMSLNPRPTPEVCEEVGKHPQADDCLQPMGWTSEMVAEHYKVSRAKQDEYALISHTRANQACLVFALTAGVFADEILPITIRGNTMTTDDTIRPGVTAESLAGLKPVFPKWGDASTTAGNASGVGDGCALCVLTTRENAEKEGMEIVGKWVASSVVGVEPRYMGISPIYAIPKLLDTVGLQKEDIDVYEINEAFASQFAYCVEQLGIPMEKINPNGGAIAISHPLGMTGTRQVVTGLAELKRKNKKLLMTSMCIGSGMGAAGIFVNEARHEIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LIE2</accession>
    <name>A0A8H5LIE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LIE2"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5358655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="151" mass="16637" checksum="96144F3520DA7218" modified="2022-01-19" version="1">MASPIPLEGGTPSVSKPIPSTKNTSWLNGMFSRIHCSTLGSAVFGNDSNATEHKLQHAYAVPIYIHIHIDVIPIAWMDDRDKIKIFQRYTLHLHLHPTPIPTGTIPIPIPTLMPLPLSVRRSLISTAIRVFVFKIEIATATATEIAAPAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQ29</accession>
    <name>A0A8H5LQ29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000028">
        <property type="protein sequence ID" value="KAF5365288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQ29"/>
    <dbReference type="OrthoDB" id="2681808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="198"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="494" mass="54716" checksum="556308DC488545BD" modified="2022-01-19" version="1">MDGLALTRRFFDDINNVSAEELSALTDVPLVSYPAKTCLVYALRLMLGPKFLGYVFSYLLQGILVLQVFIYFIAFPRDSWWIKMTVGFLFFVECLSTFFATFAAAWSIVADGDLFSLANLWGFRTLGPLCGIATLTVHAFYSWRILQVKGHWSIPALIILLSIAQCVMVIWSGTQSFLGIGTDHPSQIAFVTVWLAGSAICDFIIAGSLLVLLPKAAQKLGNAESQSRLERLMKFVVETGMITALGALSELLFFFLFRNTMIHFILFYMLPKVYSNCMLAALNARISSRALRTHDSEWGSQTSIVQEPDRFVIGDGVFHIINRDGKLVPLEEDVRKLSDEHEQYAAEMVDTNAPYQETFVPALPKEPVVVAANARATALFHSSTETLAVTVPRPLPQLEFSASDPILRDSHPRSLPIPPIIVSFSDPVSSAVASAQQLYQPDPIPSVLHSRSFSEPVLPEFGHKDPSISPDSPLVSRLHPFTLDVSDTPSSYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQB5</accession>
    <name>A0A8H5LQB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_003209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQB5"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5365588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="655" mass="75241" checksum="18197093E3745D3C" modified="2022-01-19" version="1">MSSFRPPKAEPSDPVPWSVTNTTRFQLSDENDDAPDGPNRGRHPPPRAGACVHCKSLKVRCEFIAGHSSCRRCESGNMECLSRSRKKRKAAPTHEDLQEKAHSQDYQIQNILKQFDKLKVDRKLKEWTDRAHSSAAAEGERQSVLGRTPPDIVRYGCLHPEEIRELFDIFFSKVNPYFSILDPELHTPDILIWTSPFLFTVICAVALRYCPSKRRLYYLAQEFARDAAGKALIEGSKSVSICQAYLLLAVYPVPKKKWTEDRSWLLMGVAIRMAMELELHQPPPPQCDEREALNRTRTWLNCYCVDASHAIQFGKMPMLRLDDYMARTSQAWYRESNQNIAFDVHLCAYVQILLIMVEWRNATSQCNLQEKLREGFDIVAAAIETEEKLSAELDVWVERYAEEYIINPIEICAYRGNTTQLICAYLRLVVLAAGFQQSVKSGLPRNSDLLRRSIDAAHTVIMIMIERLYPTGHLKYALEANFLYVSFAAAYLVNLLRPKFLPMLDHNTQEDIKFTVTRLIEVLSSKEVALNDRHTPALYSRFLKSLLVKYDIQVDVRTPMGEPDPSAHTYSWPDIAQTESPPGRSYPTQYDTGFVYQQSADVDFSINNFVRTVSTQGMPQHPSYDYHDIQTWDRWDGRDNISTNWSSYHNVWRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LQG8</accession>
    <name>A0A8H5LQG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_003123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LQG8"/>
    <dbReference type="OrthoDB" id="2431447at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5365709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="337" mass="38509" checksum="DC97E0C9D4DC05AB" modified="2022-01-19" version="1">MVRLQHSSLKKNRLVSAIQAGKTIKEAAEMANIPHGTAKKIWDRFCKTGSTKNLPCSGHPSKVSDHTKREMVRVAKKDRKMPFREIGNLMEPVLSASTVGNHLAEENYHRRVVRTVPYLKRDQRQKRLAWARDNCHQDWEKVIWSDECYVYIGDTKGRPDEEWDEECLVLTFKQSSIRVMVWGCIMKGKKGPLVVLEYPGGKGGGMNAKRYQEQVLDGTLAAFYEDIKSERDGVLFQQDGTPSHTVKSTKKWFSTHGIPLFPHLPSSPDFNPIKCVWRELKKLVRARRHPPTSTDELIAAVRDAWDSLPVEDIDKYIERMDGIVEDALKAKGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRR5</accession>
    <name>A0A8H5LRR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_003971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000020">
        <property type="protein sequence ID" value="KAF5367088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRR5"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5367088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="579" mass="64420" checksum="6D3C385CCFF92940" modified="2022-01-19" version="1">MQNFLFWCSFKQRPSTSFLNCFDHSSGISAWGYIKLRLAENLKLLDSFLSFLLLGVLALCILYYSLPVYTLPSYLPMSIKLLPGALLFASTLASPLFGAHEDAFQCLLGQSEPSKTLTAPPSCVINEVGFSNISPQFFADAKQQVCSAFPLTFNIGNEALSSGGDQCALEPSPVSNTNLAVQTSFNFTQWMSEQQLNANSSSPQSANASGIVGGLYEVSKKIGQGSFGVVFEGTKVMSNTPVAIKVEMNSTAPWLTEEYQLYMALNGTFGIPQVYHFGQEGLHNVLVMDLLGPSLEDLFNKCGRKFSIKTVCMLAKQMITRVQTLHEKSLIYRDIKAENFLMGVPETDNANTAHMIDLGLAKYYRDPETQVHIPYREIGRFAGSVRYLSVNCHVGREPSRRDDLEALGYVFMYFLRGRLPWQGLKAETIDLKYRKVGQKKIATSMDKLCAGFPKEFLTYLNNVRSLTFAETPDYDYLRDLFTTVLRKLNEKEDGVYDWMLLNDGQVVTNPSSKPKTRLQAHVNVVANASSESLRADREQRPNLEAQDANNSSPLVLRPAPAHAKGNLNLALSHGKKWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSJ6</accession>
    <name>A0A8H5LSJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_004484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5367987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSJ6"/>
    <dbReference type="OrthoDB" id="3251871at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5367987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49242" checksum="6855D7672C94CCFA" modified="2022-01-19" version="1">MTISLRLFSALNPSMRPRPVLLKISVQPDKSQLRTIMSSPISVSQFNFAGTLGYACTIPGTCLCFLILVAYVIVGLSPAGRAQMDRVSFRLLSYSLFFNILYGIAFSVTAAQSGPGSLCTFGAWAVNFTLTFTIYFTMCIALNLLYVKSTSQGMRMIDVLTPTSTLSLFRLVLVYRVNGRRMEKYYVIGTIIISIVLTVPAYGLHQFGWNEANSTCWFRNPDDHLRLRWLVGTQGFWMLLAATVETASSIIVLTWLFRNQMYLHQLRSNDNTTTTQTSTMHRLWGGNASTSAMIHQANRYRYVIYRISLYPIVSLIINVITTALDVNQTVKGVNTQGDFRLLVLDLFLYGIRTFVYAILAAADPSFINAIRAMRGKLPATQTPHHDHTELHSMPQGPGQTPEAVSGNDHHSVNSSIRKRTSAADDEAELEEDWEFQRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LSW7</accession>
    <name>A0A8H5LSW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000016">
        <property type="protein sequence ID" value="KAF5368169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LSW7"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="288" mass="31663" checksum="C76B6E24BFD96375" modified="2022-01-19" version="1">MLSSRTALRATSKTCSPTCSTARSYAISVRPGKVLPGKKYPRVFHDKKLFQYNWYTRILETTDSAPLIFLHRDDFSANRLKKLRKDIQTAALKFDPAAKKDPDAEPLPAPTLTVVRTSIFGAALRNFPHVKLEEAQAMLHDLPGGYAVLSLPILDPPHLNAILRAMDRSVPPRPPKTPEQIAKEEEEKKADPDQPGRRVKRQRKTLVPDLKVMGALIEGKILLPDRMKEVTQLPTLDTLRAQIVGLLSSPATQLAAVLSEASGGKLARTLEGFKKALEEGEGSAGTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LTH7</accession>
    <name>A0A8H5LTH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_003032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5368826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LTH7"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5368826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18916" checksum="9083468F8A2307B9" modified="2022-01-19" version="1">MMSTNALIIKLPRDLGLADSLSKSTLNRFAYVKLALVSTLPLLVFQTLYSLRTRLKANVPWPRVQAEPEEAEKSFEKMKFNCVQRAHHNTLENLPLIYLTTILTGLKYPVFAASACGLWVLTRIAYTRDYGSGIPSKRNLSARTGIFILWTLIGVSIYSSVNDVLPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUT4</accession>
    <name>A0A8H5LUT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUT4"/>
    <dbReference type="OrthoDB" id="3332782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="180" mass="20379" checksum="2AC1F3002FD5F19F" modified="2022-01-19" version="1">MAAAPDDILSWTNQDPRESLLFNSWGILYRFQTVVSANGTSTTTLWRTIRANKEDRVAKLEWASNGGLGRVVLGKNIFPMSDLVRPDPHTYGARVFNGLDGLVYRWRPNNNGHDVVLQDPNGNIIAFFRPTRQTRYQIGDVYGELHFLRTAGNGTVMHPPMMDMVTVTAMLYRFCALFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVA6</accession>
    <name>A0A8H5LVA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_001977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000010">
        <property type="protein sequence ID" value="KAF5370838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVA6"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5370838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="550" mass="59731" checksum="5B6813D8CE333EBF" modified="2022-01-19" version="1">MSSIELINPKAESVRRAAALQVNIAGALGLANVVKTNLGSRGTLKMLVDGAGQIKMTKDGKVLLSEMQIQNPTAAMIARTAVAQDDQVGDGTTSVVLLVGELLKQADRYISEGVHPTVIAEGFDLAKKEALAFLDTFKQSVKLDRATLINVAYTSLSTKLNAVLAKQLAADVVDAVTTIRPPPPAADAKDQWRSAIDLHMVEIMKMQHRTASETQLVRGLVLDHGARHPDMPKRLENAFILTLNVSLEYEKTEVNSSFFYSSAEQREKLVESERAFVDAKVKKIVELKNIVCDQAVDSKEKKKNFVVLNQKGIDPLSLDILAKNGILALRRAKRRNMERLQLICGGSAQNSVDDLTPDVLGWAGLVYEHTLGEEKYTFVEEVKDPKSVTLLIKGPNAHTIQQIQDALRDGLRAVKNALEDDCLIPGAGAFEVACSAHLSGPVKKSAKGRVKMGVQVFADALLVIPKTLAANGGFDVQDVVVALQDEHADGNIVGIDLQTGEPFDPTVEGIWDNYRVKRQMIHSCSVIAVNLLSTDEILRAGRSSLKPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX48</accession>
    <name>A0A8H5LX48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_005206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000005">
        <property type="protein sequence ID" value="KAF5372594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX48"/>
    <dbReference type="OrthoDB" id="3259198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5372594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="566" mass="64457" checksum="4A780458E693369E" modified="2022-01-19" version="1">MTSALTGHLKCHFLAHCPMYEVLHQRQEPPTQEEKDIASNKISLDSDAAKDYLKKLDTISNNIQSMFEKQLTVKQEPWDQAKFEELLAKWMAACDQLFTAVKDPEFQELLQYTHHGHSVIEQYRAHFSEVESQFVISLDAWTSSNGYAFMAIIAHYIDNKGKLIELLIDFRELIGEHSGENVADAVWDTLEKFGITAWVVAFVMDNKTNNDTLVEYFGQKCTEQVLKLLEAIGAVSKASSQEAYQDSATACVEREFDDEAMLFEDGEDDLRKIVRHVRSSPQHRKAWLKEVEISLSSGTSNKQETALMLILDVRMCWSSTHQMLRRALQYKSMINSYCARDKELRKFELEDSEWNSLKLASDWLKIFCAATTEMSTTKRPMLSKTLATLHGLQDNLRTVLLQLPHSADPALCWGLMEAHSKLSDYYFKFDQSPYYTWTALLNPCISSEGLASDYRRKPDLLMDIEVAKVQFEHHFLTKYQQSETLDSTTSPAVSVHIPSIDDSPVKFDFLSRYAQPSSSPSSLQDELDEYFQITSSCAKNGGMLSESNSLICTTLLMMSCVFPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY75</accession>
    <name>A0A8H5LY75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY75"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5373734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="526" mass="58331" checksum="70D65FB3A75DBE9A" modified="2022-01-19" version="1">MSISIDIVPLSDSVDMYGEGKTLSAYSLAGNVVISMSTPYLFFNRPSKVLLQSLQLIFEGQSEVWAPGVSYAATRLCSITRELVPSGEPVLLSNEGTEISICQWNVVFNLTIPGWLPPSTHFGVCGTGVSYHLYATAKFVDISDTRKRNSWSFSGIYNSLCSRMRVTDAHKVVRVRRFVRPPTTYDPEETLSCMMFYISPTSPDNETGPNRIPVDVLSKVQVLVSVPEAVNVKDNTLTFTLRLRTKDLAQEHCKRLGLGGFQVDVIQKDRCRSRPTAEYLSRYPLPGPELQPPTVPLRTSAQMVCFYDTLYSARKSEDSTWSRTFSLLPSSETGEYKLTDDTYIFAQDADQTEPAMWYTLQSHIPIQQISDDNNDVEWAGPAVLRPSWNGPLLTVKHEVIIRIPFTYDIPGTDQKAHDSFSFALPLTFVNVAPKLPAPEPSVLVAKPLAPPLGPSTPLESVPLPAYSQLYHSNGDRRIDSTPLPAYTPSSLKVPTVTVRRNSEAFRCILYHPAEKLNGLGVAANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY87</accession>
    <name>A0A8H5LY87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_000890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY87"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="331"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5373779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="407" mass="43056" checksum="F74B777CB9553EFC" modified="2022-01-19" version="1">MDSKDAHLATTYTLIFSFLNRRSHSKAAEAVKKAAKDVVVLKDGIDTGGPQLDDIIKEWKLMTAKKAALKSDDSSEDDSSSSSSDSSSDSSDDSSDSSSSSSDSDSDSDSVSESSDSSSTSDGDSDESKATKTKVTKKGGKITPVVETKVQKKIDKKKSVSKPPPLSSSSESDSDTSSDSGSSSDTDVNVSQPEKPEKATVDKTKKRDSSKTLSSDSDSDSDSDSSDSSQEKGGKDVKTKASSKKATKSAKAGDKATSSSSDSESDSDSETDTKPAKKTPQAAAVQVTKKRRTSLSGTSIATATIREGASSTSGSQSQKEDVKNGRKQNQRFQRVDPNSVSSHLVLDNRYENKTAPVNDYGAKAHADLIVTRGAGFRKEKNKKKRGSYRGGTITMQSHSFKFADTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZD5</accession>
    <name>A0A8H5LZD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_000378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZD5"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="114"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5374979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35836" checksum="2D31FDB650D84D65" modified="2022-01-19" version="1">MTPRVAILDDYQQVALKFGDWSTISNRVNIDVFTDTLKNEDAIVERLRPYEIICSMRERTKFPRSVLEKLPNLRLLTTTGMVNRGIDLDSAKERKIIVSGTAARGDSTVEHIWALVMAVARYIVAEHNNVREGNPQWQTCVPFGLSGRTLGLIGLGRLGTAIAKIAKVFNMRVIAWSPNLTPERAEQGGAEFCSSKEQLLKTSDIVSLHMVLSEKTRNLIGAAELALMKPTAMLINTSRGPLVDEGALVEVLRNKKIGGAGLDVFDEEPLPLDHPLRKLDRVTLSPHNGYANDTIYEQWWKQTVENVEKYLQGEPIRMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B014</accession>
    <name>A0A8H5B014_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_018297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000507">
        <property type="protein sequence ID" value="KAF5314225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B014"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="482"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5314225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="63815" checksum="FF71A41CCB4B168B" modified="2022-01-19" version="1">MSFVNTSAFKSFRPTPESIPPPNAVLKFSIPPGMSVHIHPLNPVTFLLRAAEIYPDKLALSSPEGPSPVFYSYGVWTQRVQNFAYALKKFGFKPGETLAIIAPNSPMIADALQGALAARIIVCPINTRLQHHEVEYILEHSQSRLILVDHEYVHLVKGTKIPVIVSNDTGRVGDPYETFLSEGRRFSQERGWQGLDVEVDENAGCLLCYTSGTTGRPKGVLTTLRGSYLAAVGNSSDARMSKDSVYLWLLPMFHAAGWTYPWAITFSLASQITLRSVDYPKIWKHFLGSGVTHYCGAPTVQIGIVNDPAAKRPPQPISAIIAGAAPTAHLIGSLEKIGITPVHVYGLTETYGPFTRSYTHPSWSSMSLEERSKKIARQGHYFSTAGDVRVVYREDDEKTTNAGGKLVDVPKDGTTIGEIVTRGNLVMREYFRDPEATSKAFQGGYFRSGDLAVWHPDGAVAIMDRSKDIIISGGENASSLAIEQELASHPHVLEVSVIARSHVKWGERPMAFVILHPQHAGKWRGEKGEREFEKDLKAHARKRLPGFACPEWVRVVGELPKTSTGKILKTELRKVVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5B5B8</accession>
    <name>A0A8H5B5B8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_017996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000487">
        <property type="protein sequence ID" value="KAF5316848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5B5B8"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5316848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="123" mass="13606" checksum="93515B824FB7BBFE" modified="2022-01-19" version="1">MTLEFLKSSARRGSTTSLELLGEAANKSAAIFLECLPIFMHHLPPRLPERAGGQANQNQNQNLLRKSHLCAELALFGIAKGAIHEDTVTTHARESLCEVRPPNVVLVDFLDQHLLVQIRTCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BE90</accession>
    <name>A0A8H5BE90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000404">
        <property type="protein sequence ID" value="KAF5320587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BE90"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5320587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="106" mass="11566" checksum="21B42C5AA288C184" modified="2022-01-19" version="1">MILSKMSSNVLMTTVPVFAGVDFNIWADILLAWLQATGLSSVLSTDHPNDAEVSTVSPLSAEDAAAQAEAITTAQKKQADWDECHESSPAYSFPFYSFPFITYFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BS18</accession>
    <name>A0A8H5BS18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_018020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000373">
        <property type="protein sequence ID" value="KAF5328021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BS18"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5328021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="438" mass="48362" checksum="773916B24BD4DB65" modified="2022-01-19" version="1">MTRSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGENTRTDVRDTAPTPPSSPPSTSTSSVALSMPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVIRHQHFKSSGLHPGNTVKLACFNTITGKIDDKIMIHYIEESDAIELIEKLKQRFDPSSTVQESNELWKLFNLHKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSSSASQGGAQQSDKSKGERANAAAPFQKPSDVKKDRKCFNCNKMGHTTQTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWVQSISSGDVEMEDSETPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5BZ89</accession>
    <name>A0A8H5BZ89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_016263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000314">
        <property type="protein sequence ID" value="KAF5332073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5BZ89"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5332073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23875" checksum="4B338FCDF84FEE85" modified="2022-01-19" version="1">MRLIGPATPGFLATLAACVLLGIVSFCVPYFKSVFFLKAGFQANGQNGTITFGTLGFCLELGNGTTCSKPQVGYQLDINRLVGDNNPNIQIPQIAVRWLTYALVLHIIAFCLALLSAVFGLLAHVCELIGACFSTCISGFTSTITLLAFVFDIALFTAAKSRINHVDSGSATTGNAMWLTLAAFLLLLFTGCFYAFGSCCISSGGSSPRRKKRQDMEYGKISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C0T1</accession>
    <name>A0A8H5C0T1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000315">
        <property type="protein sequence ID" value="KAF5332048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C0T1"/>
    <dbReference type="OrthoDB" id="3111310at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5332048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="663" mass="73836" checksum="0CA9D12DA715209D" modified="2022-01-19" version="1">MTSRQTRSQGSAPDIPLPTTSRHSSAHPSGTQTPTPPVSSTSQAQPLDPLFQNPLPFPLDPIMSDAGENTRTDVRDTAPTSPSSPPSTSTSSVALSVPENTNPNYVMPLSDINKAFDSLTVLTGSENWKMWYFRVNNAIRVIRHQHFKSSGLHPGNTVKLACFNAITGKIDDKIMIHYIEESDAIELIEKLKQRFDPSSTVQESNELWKLFNLRKPVWEFDKLLDEAQDLWASIKKRDIDVSDQVFYSALVGIIPPHYHFVRSSYEATVDAAAATWDATTAAEGEKPVYRAVDLIARLKKEFTNYRLSNARTYPSKKSDKKSGSTSQGGAQRSDKSKGERANAAAPFQKPSDVKKDRKCFNCNKMGHTTLTCPEPWTEKSKEAMKKKGITKQSNKGKTKENASVAISMPASSSSQIATTSTSQSDWVQSISSSDVEMEDSETPVSHHISLPAFTAISDQDHTHIIDSGATIHCTPYLNLLFNVHTTPAITLTVANSEHLDLQLAGDMRVEIRKDNARTSKLTPKGKRGVWLGFDDHSKGHYVYFGTKVNVERNLQFLTSKSQVEGELQNKNQEPLETTEENTTETPTSQEHEPEPMDVDEDETKQPDGPRRSKRIQEARGLLYDEVEQNIAFFLTEFNVYYADNVGDPISFKDVLNHPQRDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C2U8</accession>
    <name>A0A8H5C2U8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_017600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000277">
        <property type="protein sequence ID" value="KAF5333948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C2U8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5333948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="367" mass="41036" checksum="01DF2472B910880F" modified="2022-01-19" version="1">MPVVLIGYERYEDVSFEVVITSTSLLIPALPKDKSHHVESIVLVTGGTGLLGSHLIAQLLATDKYIIRGTARSAQKLRDIFPNEPRLEVFEIPDWSSDHTEVLKGVQAVQHLAAPLFYNKVENGEVLFNGVYGGALHIVKQALAAGIKKITYTGTYAALFELHPANRFRADRPLNEMSFGNVRKDLNIKEVISDEESLKVLYIAAKIIGDKDTWEIAHQHPDVDVTVRPVVPNFPVISRTSLSTNDYVYQLILNGPDTYPPVSVGDLVDVRDMARAHVLALLIPGKDKRFIVSGGKYHWKEIGDLIRRERPEVAHRLSREDVKPMEQTVSPIDLTFTEKELGITEYHGWEESALAALDCGLMLEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C8B2</accession>
    <name>A0A8H5C8B2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_017712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000221">
        <property type="protein sequence ID" value="KAF5336783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C8B2"/>
    <dbReference type="OrthoDB" id="3119798at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5336783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="62935" checksum="95BA744D032C77C1" modified="2022-01-19" version="1">MRKLSESLISPEASVENSTPPPHTPSPQKPPATPKHNRTGFPVSSPRTPSPNKPTKSSPLVENEVDGLLSYKTSEDHCRVSAGLRLLRPPCLTVSIPITIYSGIASTDGEEDATEPESDDFCDEESVHDDEEYDSAAGATDEAKEDGSAAEDNDGIDEGAEQDEDEDLDDNLDSASTGSTPAITINNDYAKKEVDNKATNIEGANKSHTVEEVKHTRKSPEDRSLADAIRWYGDGHHSFTYDPPRALCEVMKDSFKIPGLDTAGLYDNYDPLRVSLMLSFNLQPVDASSLKWENVKDVLYKDRVLSLVVDFLKFDSWRSFCNPARCHVLSFDWGSQRLPSGINIEFLQAARFKSLNDNRGPLRIMLSVGSSRLAQFEYTASVIGNTLEETSYIGPTVYRDVEWEGKSGPVGGVQYSTCIGPFKGNNVQRPPTAEQLKKFDEAYSTNGPGKSSSSRKSSNTYKAQATSPYTFKDPQELQIQHTSAFPKPPSTSMKLALPIFDLALKPGRRAFKLPDDLQNINAWPLWPASEPHRDAIVVVTYMVTRYRNQKNPSSWSVTFNLLWVGVLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5C9J3</accession>
    <name>A0A8H5C9J3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_016737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000226">
        <property type="protein sequence ID" value="KAF5336653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5C9J3"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5336653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="365" mass="40237" checksum="C744F69DCC89B80C" modified="2022-01-19" version="1">MMTSSPYKPLVFVTGASGYIGYGVVYQLLEAGYRVRGAARNTKVDRLNLALKKYVNEGLFEAVEIPDIASGDLKKILAGADAVIHTAAPLIGKSHAEVAFRTAVEGSLHVLEEGYKLGIKRFAVTGSVASFPSSGPFGDDDWNTLTKEEAIESNNPRTIYLVQKKVGEQAVREFSKEHPETRIAIFNPPYVYGPFSPGFQHILGSQWKDQLAAGTRPLSTAGQIYGLLEGEKANNFAALQPVPYVDIRDVAKVHIAALQLDHEVPEPLNAPRLLVVSPYLPKFGESLEVIRKERPSLEGRLVRLEGVEEVKGGRDLKEFDEVKTGLKKIEEVLGIREDEYKTFRETILDTVDSLIALEGFNWGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CA32</accession>
    <name>A0A8H5CA32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000217">
        <property type="protein sequence ID" value="KAF5337494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CA32"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5337494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="26984" checksum="8F23DD3D2C3D7BA8" modified="2022-01-19" version="1">MAAPTHSVHVSNISPSTTQQHLSDFFEFCGKITSIDFKQDSKEATVHFEKPSAAKTALMLNGGTLDGSQLSVTSDITHPDEEDTSTEPVSQSDKPRAAVAAEYLAKGYTLSDQILQRAIELDNNQGISKRFLSYFHSLDSGIGSRALGPDKTISGKVQETLSAATQQAKSVDEQRAISKTAHDYYTKALGSPMGQKVYEFYTSTSKQALDIHEEAKRIHAANKASTSSSSPTTTTSEGAKPGGDPSVPPAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CB53</accession>
    <name>A0A8H5CB53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_014261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000201">
        <property type="protein sequence ID" value="KAF5338034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CB53"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5338034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="372" mass="41574" checksum="33F388CC468C5856" modified="2022-01-19" version="1">MVKQGSESPPPRNASGKVAGLPIISITPYLLDETSRDDIRERRAATSSALHRACRDFGFFYLDISAFADPREPDELAKLGRAFFSLPQEEKDKLGLKNEDYARGYQRLRENVTNGLADNHEGIDFYRPVKNPDKSKPLWGSNQWPTVPGFRKKYEAWTGKMQMLGMIVMEAMAIGLGMSQDEWKALSGQVDNSFWVMRVIGYPPLPNDHAGFSCGAHKDYGCLTFLYADPTPNALQVFVPKSRAGAAADLTGLPAEQGNEKGIWITADPIPGCVVCNIGEMWEIWSNGLYKSTLHRVVHRGNNYRVSIPFFFEPNFDAKIAPLPAALRIIKSEKKEAHNKDELKMREPVVYGEFLKAKVGHNFTNGNGKYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE64</accession>
    <name>A0A8H5CE64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EML-like second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_016853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000178">
        <property type="protein sequence ID" value="KAF5340155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE64"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="152"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5340155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="661" mass="73468" checksum="B937A8AF3CD32832" modified="2022-01-19" version="1">MWDVQTGHQFGEPFVGHTETVSSVAFSPDGRHVVSGSADYTIRIWDIQTGQQVGKPLEGHTERVWSVAFSPDGRHVVSGSNDNTVRIWDVQTGQQFGEPLKGHTEGVLSVAYSLDGRHVVSGSVDNTVRIWDVQTGHQFREPFVGHTKGVCSVAFSPDGKHVVSGSTDTTIRIWDMQTCQQVGEPLEGHTHWVRSVAFSLDGRHVVSGSDDETIQIWDMQTCQQVGEPLEGHTDWVRSVAFSPDGRHVVSGSDDCTIRIWDIQTFQQFEEPQQLSNHTDAIRSVAFSPDGRHVVSGSDDCTLRIWDIQTFQQFEEPQKLSNHTDAIKSVAFSLDGRHVVSGSDDCTIRIWDMQTCQQVGKPLEGHTESVQSVAFSPNGRHVLSGSDDCTIRIWDMQTCQQVGKPLEGHTERVWSVAFSPDGRHVVSGSGDKTIRIWDMQTCKQVGKPLEGHTAWVRSVAFSPDGRHVVSGSGDRTIRIWDMQTCQQVGKPLEGHTSSVQSVAFSPDGRHVVSGSYDQTIRIWDMQTCQQVGEPLEGHTYWVQSVAFSPDGRHVVSGSWDKTVRIWNIDPSNPNLIPASISQYNKKNQSCSINPQGWLCTAEPEPKLILWIPSHLRGGFSDLRQAGTIPTDAENFAVKVDWSKFVCGENWTSVWNDNPEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CE88</accession>
    <name>A0A8H5CE88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CE88"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5340185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="695" mass="77882" checksum="676094A6A62BCD68" modified="2022-01-19" version="1">MSAMPRFFLGLLTTVSLSLLALRVFTYSFSWSNVQALQIPISQWLSTLSIPISPVSLPFSSPGQPTDSDYLSYDLDHDISNWNLTQNPAYTTSNSNLIFTTASSLLQHWPNARYRNGHTIVPGRIPIGTIFYHGRSSPDMVESSKAGQKSGADAESTKEKEKEKEKAKAKKTKGDGDDCWFITLVTTRELRVLYFDGSSAAKMIGGSMDSQDAFAYRDELELEAEKAEEQKDAPSRWDDPGRIFGEVERLRRLCQWVEEQGLGVDGFVRMEMDFEVMLCDMSSGMDVLSFVNLAHSANPNSPSNFFSPGPDPSSSSTLDSTSSQSNHVPMANPRITIRNFELAHSASQHNAFPGEMKIKLDMDGLVSFYDEELVRKSPYFVDNDNDNHNHDDAPDRWTHQVRRVSKEDARRVRERVEEVLLRQKEMKAQGASGIDWQLLIQMLIKRYASRLETLEYLLAVGVRGLPEAGEGEGGIGIARMDSERVQTVFDQLEVALSPFILADAVPAPSPAVVTEKSKSGSTASSLDWASSVYKLCATTHTLYLHSPHILRKMTKSERTLLKAVEGSNKEICRVLVTFWAEGVENGLGLENMYHIKKGTNTQMGSLRQRWEKDLKVLMDWLDWSVWQRCRPACGPEACFLEMCYMPTWPYFAGTGGPPAGPAQGPDGMDTNAQSNRDDWERPKPMCIRRIAPYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CF91</accession>
    <name>A0A8H5CF91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_014901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000182">
        <property type="protein sequence ID" value="KAF5339698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CF91"/>
    <dbReference type="OrthoDB" id="3156891at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="138"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5339698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="485" mass="52044" checksum="150AA7070FB602B1" modified="2022-01-19" version="1">MPTAFEDPVTLRVLSRIYLRCGSRLDGIQCEYDDGLTTPWHGGQGGTAQIFVLDLTKGEAIVSMTIWSGLDVDAIQFVTSLGRVSPKYGGSGGSPGIWRGNLGNKARALMGWKGTSDTLVRYLEPVWSDTQDLSGTHVVVGESKGGNGGTAFDMLDTAGDPLTTRLSSITVHSGSGIDAIECTFQVGNKTVSSGKKGGNGGSAHTFELRFEEQITRIEGRANTGLCKLQFFTNQGRSSDVYGSNTAGDPFIWLPPSYDPNNPGAEVTGLICFEGASGKMVDRLAPVWAANPPLSYQLIIDDFDESQLQQNGKVEAAWAAEKVTDNFTNDPLKSTFSWSMSAEKTSTITFSQSTRSLIGGKVSVEVIARGKVGIPFVGEGEVETKIAVEVSGEKEWGSEVTDEKTVSRSYTETHSDEVIVRPMCQGQGKAIGYRMECADLQWKGKMVIIYSDGSTRTVQPVSGTLTSSSMTTIHATYKSVPLSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CJB7</accession>
    <name>A0A8H5CJB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_017128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000156">
        <property type="protein sequence ID" value="KAF5342784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CJB7"/>
    <dbReference type="OrthoDB" id="515270at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5342784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="440" mass="49468" checksum="2E0A99D744306985" modified="2022-01-19" version="1">MDILTVNHSLQELAIQKAHRKPRTRSGQGTSTPTNQPSEPNPVPDTPTNNPPEPNKPTSPPSSPIIPSAEGPSVAPRRPPTPPSPDPSDPNDSVMADTPPIGSNGTSERGRKPDPFNGERNEAKRWLAQFNNYLRMNKGRYPTEESQVSLFLSFFTGEKGGDWATQRLTKRDADEEDEELTDTPDQWRWITLKEIRDRFKRDFRPLASEDVARTKIKFARMKGTDISGYNSIFDTYGEEYEFGEAALLEFYQDGLPPKLREAVGRTYPKWKNFDQYQERAVELHLEWLKERERQGRWKTTSTSKNSPGPSQGRTVASVNALMGSGANSSFNLPLKLTPDERDRLRKAGACFACRQTGHMSNECPTFPRTSSQNTSRTFPSRTIRTTETASPPPVTVAQASSSRTTIKEISDMVNRVKGLEGEEKEQATIYLKDIMSKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CKK8</accession>
    <name>A0A8H5CKK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_011163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CKK8"/>
    <dbReference type="OrthoDB" id="3251587at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="226" mass="25705" checksum="6FF0C1788D5FC0F9" modified="2022-01-19" version="1">MLSMLASVDRLPADTRERLGIFVKRAIMWDPPAQILGIRSPEGTYIPLEDENLSPEARLVEFRKWVTYYFVHGDLSARDPMQLNYKTPDPDRKPTFEHLPIQELLSLVDLAPGQKCDTVVCEPAFADVEWGIVNKALFDRDVRATWSSMTMWHIFGDACPWNVYLAAWRLEDEAKKSDLAVNFTMTRGANHFVGAISCTLNKDLTLSFQPMWDNPEGALSELSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLR3</accession>
    <name>A0A8H5CLR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_013412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000145">
        <property type="protein sequence ID" value="KAF5343246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLR3"/>
    <dbReference type="OrthoDB" id="2745518at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="512" mass="58082" checksum="52DE5838193C21AD" modified="2022-01-19" version="1">MATRGSLIVAIDHSLPNMNSLPLDDDVLDRILTFSPSFETLSSVILTSKVFYNVFSQRSKSIVRAVAHNVVGPALPQALRVIRYQLPGTDDQYKVYDDLPGPESDEALEVPITPAEAHGLAENASVVAFLENLYSLRHKDIRFRTSQLTSTESHRFCRAVYRIALYHRVFSKARYSSPSLRQRAPRIIELDPEDEDTVVKTLNAAKESFVSDFSTEELYQIQALSFSLQEAFLWLHSVSRGVLIEERLCNLDNDPRVTFNRATKLIPPEVSVSPAGGFASNHVLVFSDLRQFLAYPSSNPVSLVLCLRGQQPPTTDSGSKLWGSLLDSSLIQEEDRHCDQCGGSNEPRLLYGPTTYYYLSGVSYQFRPSFMHNHLKGQLKYNLTEVEIIRKYTAVTGLDVLTEDTFTSILHSIHEDGYKRPEFESWKKEDWLCTSCMVKILEEHLHLWLLHMKRKDTAGEEIPEDCGDTTAQTKMKLMERDSIIFATKHDLSEALRSEECTYTGFNVMDYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CLV6</accession>
    <name>A0A8H5CLV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000150">
        <property type="protein sequence ID" value="KAF5343057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CLV6"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="336"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5343057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="965" mass="110771" checksum="56458DD9DB1F20B9" modified="2022-01-19" version="1">MDSQKQTWQTKSVKKSCMDPAPIPATSTSEPSLDSPANALANANGPDSDSKVFDADEFVGLGVIHYESLFQKLPDNNKAYSFTAIVDLTGLTDSERLQEKADDFVALFWEKTQMRFEYEGKYSHINTPSTRFKYSCAQTASRQSKPAKHTDVCNRDKGSMDTFDCQGWLHITVFEDSEQAFIKFKHHKDHCDYPKTTVPDDIQHFVEDNFKMSTSALWSEILGKFPNPAVHRRDVYAIANAKKSQRWKRDPDEVKSAKILLEESSKKSNDSGNHYTIEAIDLSLVEGYIGLAFTLPDVLLKWGGQIREILLDSACKILFDLNALNDNHNLFIPENTNGSHYELYALIGELYGSGCPLGYLLLQSPTEGKPGAKEKYIHSFLEHFKVKHDLKPIFTLTDKDLSKINAFLKAFPQAKHQLCFWHALRAVKSRLSVLRRSPKYYDVKEARNEFGDEIDKNFVPVGQVSEAERVNFVVSQTMIPRVTIRIGGVLQNTAPPKPRLTIRLKPLSEVTLKSSKSMDQSGDLDEDEIMDDPAFDKLLDDTETDEEFGSEYMFDADEKCSKDPSYVFCPAPHRKQLLHLFTRHFCQHPIFPECFQTESMTSEEIRRNAVLEMYQFCYVRGLREVWGYMWTSWYCPKMWRLWARSAGPDYLSHLRTTMNVENFWKQLKHDNLHHLLHPRLDQLVWILIHEVTPSYMHCIAQLESTFMIGKSQPLTNYQRYFKTDWKKLLSQPASKRADYATDVYAWICNCRQQKYNRHCLCKHLVQAVGLPSPRFFQHVIQRRTCPIYCHPELVPLNMPPRMYSDMDDGSITDGDDQIWLGDKSQLIDGQWRELTSGSVRGTKRRASSVSRSSPELGASTGASSPIGYGSDGEDIDKDIEYATDLIETLRNAANIIEAQIPHKNRLWLKSLHTREIGRDISHFVKDVREFESPRGNRETTWARKQKGDNRRVANTMGYQIEGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CN08</accession>
    <name>A0A8H5CN08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_015893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000132">
        <property type="protein sequence ID" value="KAF5343853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CN08"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5343853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22864" checksum="524B2D2D22FA0CC4" modified="2022-01-19" version="1">MAKIATPLYLLFPWVKWLVPQKQLICRIENLTSKFMDLLEHKRDPGNNMMTYMLKDPGMTLKELRDNMIVLFLGGHVSNISDAIATTLNSNKFQDTTAGSILTLFYFLACHPEIQVKQVFGDNQNPTVDLISGISLPDLSACIRGLPTWWKWCCVQAVFPVDIQALDSEKLRGLVSYMYFSCRYAKSTYQHFPPDLTFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CNF0</accession>
    <name>A0A8H5CNF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_010412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000115">
        <property type="protein sequence ID" value="KAF5345066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CNF0"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5345066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="570" mass="61439" checksum="A90B219E939C652F" modified="2022-01-19" version="1">MSTSTASESSPLLADTHLKPSKDAETRQLGPLEIPKATRYSILLGVWTATFLSSANMTLVPTMLPSISSEFQKSHQASWLGTAYLLATCTFTPLYGRLSDVMGRKGAAQAAVLFGGLGTIACGLSTNMEMLIASRFLAGIGGGGISTMAAIIVSDMYSLRSRGLAQGVASVFNGLGFGVGGPLGGLITDCSSTNAQVGLENGIFGSSAAVPFINLLISVNLLISVNLNYVTPGKGKSTVEVLKRIDYLGSTTLLITVASTLIFLSTRYNEGLPWTHVTVIIPLILSVAFFILFILVEVFVAREPILAPFLLKQKVPVLVGISNFLVSSCNFAMSYYFPMWFQTVMLTNAAIAGLHSLPSSVAMPVGSVFAGWMMHRTGKYKMINLTFGILPFIAGILIAQIREDSGPIQAWFSITPIGFGNAVVMQTTLVALLAHIQESQMAVATGFARLFGSVGQVAGVAVSSALFQFVLEGELRKRIHGPDSEEMIKRIRQNTRLVETLPVDQQRMARDSYDVSLKVVFWFAALSTLLAYIVRLPIPEKDLERTAEESGQDQISQQRIPGLEDSERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQA2</accession>
    <name>A0A8H5CQA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_013862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000106">
        <property type="protein sequence ID" value="KAF5345994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQA2"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5345994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="859" mass="95417" checksum="36B13209FDEBC868" modified="2022-01-19" version="1">MKFSSSLKFNAVSEWWEEYIDYDNLKKKIYQLEKQQQSLSGSYQDLESNESTSLVGRQRHTDSVFIRLLDKELKKITLFYESQEEELLERLEKLEQEVQAQEEQGLEGDHYQDDFDDDDDDDESISRSPVGRRLSIGARRRRLSSTLSRNLPLIETDSTIQEGEALSPMSPASPRQHRHSISSDEGDMEDSYASLRGQGSLPRGPLGRLANMMNSVSSSMMPDTIWTAKSNYAYDTRLLYKRKITELFIALSSLRSYVEINYSGFRKILKKYDKVTYSELKDHYLHDVIENALPFTQPSKDRLNNAIDRLIDLYAKCVTKGNTSQARQHLKLTQRENIAWERDTVWRQMIAQERRGELSAAGGLGATLVKEPVPALLSIPTPLGTLRVTKRLLYLAIALLVFVVLLNVQVVDGREANRCFAILIFCTILWATEAIPLFVTSIMVPLLLVWLRVIRTSDGTHELSPQDATKFVFSIMFSPTIMLLIGGFTIASALSKTNIDRILITRVLSLAGTKPRTVLLAFMGVSCFASMWISNVAAPTLCFTLIKPILRNLPRKTSFAPCLILGIALAANIGGQSSPISSPQNLIALAAMDNPLDWGRWFAVALPVSAIQLLLIWGLLLASYRPSKAPDGEKEIEIRPIRATRESFTVKQYWVTFVCLATIALWCVAHAIEDYVGDMGVIAIIPILAFFSTGVLKKDDFEQFTWTIVFLAMGGIALGKGVTSSGLLDVMGDLIRDLVDGYSLYNVVLILSPIVLVISTFISHTIASVLLVPIAQEVGKGLGGNHQDLLIFITGLICSTGMGMPVSGFPNQTAATQEDELGELYLTNVDFLKNGIPASVIAMLVISTIGYLLMGAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CQL5</accession>
    <name>A0A8H5CQL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose receptor Git3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000113">
        <property type="protein sequence ID" value="KAF5345271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CQL5"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5345271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52177" checksum="1742639397B25BE6" modified="2022-01-19" version="1">MSAYASLPGGAEYLVRVEYPSSEASGITAVVVVSFISLLAVVSLLAVISISALNTRTSLDHHLFVRMHVATYFISLLVGNLLQAVGSIINVTWVASKAVKDPGVVKHVADLSMAIWTFAIAMHTFCLLVLGLKIQRVTMIATVVSGWSGTFALVIIGPAVLGTKGPYFGISGRWCWITEQYPAERITQVFMAAFLSLSLYLLILLHFRGVPVLSGLRAYFRETSIGGDYEFERKGMDIAKKMLLYPVAYGIIVFPIAVTRFSEWAGAKPTFAAIIFSSVLFQMSGIINVCLFLTIGRVLPPQSVNISSLKRGISRPRTFKPPPPILVPGNSDPYYASSDFDPIPPIPDIAEDRNMFPEPELYVHAGNAEFTEHPEPVVPKVFEEEHTVAPLQIRKARQDMLPDIEVSNRLDSVYDYYEREGRRGSQDSYYNHEDRDYATGRSGDSYKDVDLDDIPNERPDSDEDSVYSNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CRF3</accession>
    <name>A0A8H5CRF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_013079</name>
        <name evidence="6" type="ORF">D9758_015046</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CRF3"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5345683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5347477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="362" mass="40605" checksum="799FD73E885AF6FA" modified="2022-01-19" version="1">MPPTVQTDVKVEFDPKNMPFRRLGPSGLRVPVFAFGGWLTLGQSVRGTRTTELIKVAFENGINMFDTAEAYNNGESEIDMGNAIKELGYRRSDLIVTTKLFWGVGRKAPNSAGLSRKHIIEGTQESLARLGLDYVDVIFAHRPDHSVPMEETVRAFNFVIEQGWAFYWATSEWSAEDIEEAFHVATKLNLMGPVAEQCQHHMFHRERPEKEYAKVYRKYEIGTTVWSALAGGLLTGKYNDGIPEGSRFDVEKTFFSNTIEGLQSAEGKEKIRKVRELTKLAKEELDTTPAVLALAWVARNPNTSTVILGATKPEQILENLKAIEVMKKLTPEILEKIEKILGNKPDALPTFGRPPLDLIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CSB7</accession>
    <name>A0A8H5CSB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_009923</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000105">
        <property type="protein sequence ID" value="KAF5346171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1219"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1899"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1941"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1975"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2005"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2093"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1321"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="2159"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1669"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1682"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1699"/>
            <end position="1716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5346171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2494" mass="271739" checksum="ACF34699D44A523A" modified="2022-01-19" version="1">MSDNSATPEIAATKPKKKPPACDQCKARRVLCHSRPDGKSCPRCLEKGIKCTTTPVVRRKRRPQHEVAAGNSKDSEDPEMNDNGNENHVNGVQPMDLDTAMEDLAPQGQERPVASTSSLSVQKTIPAPEILEANIPSPQTRAPSMVPTTSSAGPGLPYAQTTVTLMNQPRLNGGPSSSSTSLQPSSTPRIQLPKHLIQDLFNAFIHTPYSHHPIIPYDRVRANLAGCGWQPSSLTPQECVLVYCIFALTSLISIDPFIIGQEPIPPECTNILTTLNPVKTIKKDLRDIGRRREGVCHQLRLEALRQAQAEGVAVSVSPENAASCFLLSSLELLNQYDSTNAYSAVFAWQARALAESWYRHPHPSNSLFGTRDLSARWRSFIMADAIASLFLDRPSAFSPHDERLLCGHDGLPMEKLVSLLEEQGCNGTQFYMYLPSIMFQMTHLTREVYENISGSYARRNPLNLQIVKHYSSSLNLLHKLCSIYSSAADALTDQTQRQNFARLSVLSVVTLGWTNLSLYFYKTLKVRLEETSVTYSYSYAYAGILVGGEGNEEGDKSKSGGAGSDGDEAGAGPSTGSGLESTSTSAARERGTPGSGPGSGRTELERIFHETRTLTCKAAIEFSKMMEDVLSVSRLAQAKLVGGGYLKNWVHFLLDATEAGVMAASDGARALERLRDGLKVAGFAWVDYTDLVEAMDSQISALHASSGSLNPNPGHNPNVMPSPGVAPLGGMGIGMGAGSGSGLGMGTGMGMGLGATPYDPLFSEYGPMSWDTFALDLEAMNNAAASVQYQSARGFHDSFVQTAKSLDRCDQQVDRNFVDTDIYIVAKEFGNSMPARRACRPASSSSSSSSLSMSSLFWRQFRALFRKNWIVLGKHPLLNILRCFLLPVAYGVFLAVAQLFLIKPNNNGIGAPVPVYSLSSKFDPSFSLLWVDNTNGSSSPTPREIMDRITADFTERQLSSVKQIGSPGDVPKECPQNFNLFSECFGAVVFNDIPPAGSSNPRRPVNYTIRADGGLFHVDVVKHTSDFEQRILPLQWAIDKAIVELQTSVQIPTPLEWPFTQETNEEQSRDIRLSYIRGLRTLLVLALFICYIGIAYQLPGAITGERANGLTAHMKTMGLLDSAKIVSWFTSLIIPYLPAWTIVSLTWHYRIFTESSAGLIFIVHILLGLSLASYSLFLSVPFGKSPQLAAVFSTFLSIILSIIALVYAGSERGATTTGVTIFSLFFPPGWYIFVIRVICGWENHLMPTNLLKQDPDSGLVLLPLIIVILIDIVLYPYLTIKWENWLYDTKNPPSRSTPSKNTSFSLSPENQLESMSDSTAISIRNLHKSFDTSALSFLPSWIRKPRNRVTAVHDLSFDIPKGGIFVLLGSNGAGKSTTLSILAGLLSRTRGSVRFHPEYFGTGRGESGGKGKKVDRVGLGIVPQKNVLFDELTCLQTLEIWKAIKWRPHSPSPSTPGSKHEEDLIELLKDCDLFQKIHENAGTLSGGQKRKLQLAVGLVGGSEIVLIDECTSGVDPLSRRALWRTLTRVKMDRTVVFTTHFLDESDLLADNIAILASPVAVRFRVLDEDNEKDHVSAGVGTGSDHDTSLKLLQDIRKVAPSAYIQDYSSKRVTYHLRTKEQAVVSEVLKVLEAAQARGVVESYDVLGTTIEDVFLELMRREEVAVEKAQVLPEDASGSIQSGEHDEAQREKDGEEKRLSTPSGSDTHTQIGTSSSLMAMKPPKSAITPLSLTPGRPTSPLQQALTIFHKRVLIARRAWLTPLLAVLVAIFVESPPNVLQNVLGSQNLINLNVSSSEPLAFLRTTNVADNQTFVQEFSTRFRNYSVGGVSFNSNPGSGPALVAWEASSPGLTGPAVLNMASNVLYNMALNSSGSAGADPTIIRASYESFPPVATGTLSSLRWVVFFGAAMSVYPAFFALYVSQERRSSVQAMQFSNGLSNTFGLWMGHLMFDFIFALISSTIIIIIFAAVSNQFHGLAIFWVILVLYGIAAILFSYFVSLFVSSPLAAFAAVAGYQVVMFVLYLAGYLLTLTYAKTSEAGHIITILHFTLSLLSPAASVIRASLVSVNLFSLLCIGDTITSSALGDLVRFGGPILYLILYSLALLAALTWYDSSGSLKPRSFLRAAAAAVGHSNHHINATTSNQDVLDEASATAKSGDLLRVLGVSKTYGKNTVVDDVSLSVSRDTIFGLLGPNGAGKTTTFNMIRGDVVPDKGDVFIAGTSIVRNPKTARFSLGVCPQFTAIDSQLTVREHLLVYGRLKGLDKGEVIESNIDMLLKATGLQVYAGRLASALSGGNQRKLSLAIALIGNPSVVLIDEFSTGIDAKMKREMWVTLRNVAVGKAVIITTHSMEEASALSTKVGILAKRLLAVGTTESLSERFATYEVHFTCRTREEVSRAQLLMSRIPGSRLADDVATRFEVPIRSPSNKEEDVPPSEPSSRTVTLAELFHILSESGDFSEYTVEKASLESVFLKVIRQNNVVEEDVDKRKPWWRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CST0</accession>
    <name>A0A8H5CST0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D9758_012755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAACJM010000102">
        <property type="protein sequence ID" value="KAF5346403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CST0"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034209656" description="alpha-glucosidase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="12">
        <location>
            <begin position="167"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="11">
        <location>
            <begin position="305"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="13">
        <location>
            <begin position="736"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF5346403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="979" mass="107772" checksum="675AFF72C1C600BC" modified="2022-01-19" version="1">MMWTICGLGLFGLALAQESSGTTDTSRDVSNCPGYVLDNLEETPNGLSASLTLAGPACNAFGTDITNLTIEVTYETQTRLHVNIFDTANKQYTIPEDIIARPAPPQESFVNSSDLLFSFDSSPFAFWITRRSEPDAAPIFDTRLASLPTTPIPSVNDDNSTALDGFALVFEDEYLQLTSALPLDTNIYGLGEYIASSGFRRDVANKGSIQTMWARDIQDPTDQNMYGSHPFYLEHRFNESTNTSQSHGVFLLSAAGSDVLLQTPPNSNTSLIQYRNLGGTLDFYFFSGPSSKSVVEQYGELIGFPAWVPAWGFGFQLCRWGYLNINDTMDQVINMRAAGIPLEVMWNDIDLYHAFRDFTSDPVSFNGDEMRAFIRELAANNQKYIPILDAAVPVTVNDTDVYDPYTVGSERGVFVKNPDGSEYIGQVWPGYTVFPDWFHNDTEQWWFEAMTNWSNGGIEFSGIWLDMNEVSSFCEGSCGTGANLSNTSPPFLLPGDAGAEITTWPECYDAERFGNSGNITISGTSTCTTQSQGVELEFVSRGLGAAEYSEVNVVDPAYAIHNGFPSLSNHTLATNGTHANGVLEFDVHNMFGMMEEKATHRALQKMHPGKRPFIIARSTFPSSGKWAGHWLGDNSATWEYMYQSIQGVLQFQLFQIPLVGADTCGFMGNTDEELCNRWMQLSAFTPFYRNHNQRGALSQEPYRWDSVAEASRIAIKARYELLPYWYTLFANASTRGTPPVRALFFEFPNEPELFAVDRQFLVGSDILVTPVLEQNVTSVEGIFPGRGNVIWRDFWTHEVVSSSNGNGTGTSTATQKATLSAPISHIPVHIRSGSVILMHAQPAYTIEETRAGPYTLLVSLDSDGAAMGDAYVDDGISDPVGESRVLRFSVGVSNNGTSTLRINSEGEFEIEQKLVNVTVLGVGKVPGSVRVDGEEVSRNTGTGWSWKEATEELIVQIGNGNGNGTNGIDLNEEHVLEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CT05</accession>
    <name>A0A8H5CT05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_015041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000094">
        <property type="protein sequence ID" value="KAF5347479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CT05"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5347479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="406" mass="46284" checksum="7280F9E19E4AAF94" modified="2022-01-19" version="1">MQPKKGYTKVVQACVRAQSSAFDWIWINSCCINKESSAELSEAINSMYQYYEDAAVCYVYLFDVSTKLHPRNPKSNFKSSRWFRRGWTLQELLAPEYIAFFDEDWMKIGTRWSLRNVISVVTTIPIDVLEGRPLDKYSVAQKMSWAVRQETMRPEDKAYCLLGMFGVSMSPIYGEGGEKAFMQLQQEIIRVSDDQSIFGWIGYEQERGLLARSPLEFRYSGQVWASVHHHIRFNNNGLYIHLPLETHNYHSDVFLACLLCQTNDGSYVYVYLRKTTGGYYVQDNTSKVVLRSAPPAPLGNVRELTVREGPICRKGRTRIHTSCRKVESQNCVVCLPSAQHFVCSRPPPPEASISTEFSVGFQTSELQSADLTYEDPSKSQAFTLAFMVGYVKDDARGDTILSSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CU08</accession>
    <name>A0A8H5CU08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000089">
        <property type="protein sequence ID" value="KAF5347850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CU08"/>
    <dbReference type="OrthoDB" id="5983694at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5347850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="86609" checksum="D29558FDE5FBDA86" modified="2022-01-19" version="1">MKSKEVSDMEPIDNDPNQTGIGNQWDLFSRAHHMNVVESTITSIGRDGYYTYITNLPESKPKEITTDALLLQTPQPPVIFMSRSKLVEEAVNILRGTNQVHIAILGAGGIGKTSVALHIMGNHFIKEKLAGRCYFIPCEMLPDATILMQGLVQAIGLQVTQGKDSFKLLLDYLNSGQKVLLVLDDFETPWSGSGQTKIRNLIEVICRCESVSVIVTMRGTDGPGQIKWHKLGGGSGLPALVLGAAKEAFYSFSSDGSYTIKQEDPILEQLLIEMDGMPLAVMLIAELAKELPLNKLMEMWNIQKTAILKKFGLGEQENRLTSIEVSIELTLNIVRDKLSPTGKNVLRLVALLPSGIPDWLENLPKMLTDTNMQGDDTTTQAVILKKSCLIYQAGDTLKILTPIGEYIMKSFQGTDHLENQAWRFYESFINSLPQNSTTGDIQLELHVGNIFKILEIQIKKSFERSHMKVLQQLYNYSQYFSRLVPLVEIYLGWKSQMNLSDQTKLMFLQERMLSFMGEYERAIGIINDVEEHHKHQENQEASNLKVVTYASSITMNNAIEQTKAECNQRLGRIFYFQSNYTLSQQNAQQAKDLYEKIGDMRGVAQCFQNLGDICMMLDQYEDAKVMLQQAKEQFEGVGDRLGAAQCLRSLGDICRMLNQYEDAKVMLEQAKEQFERVGSRCGAAHCLHSLGNICSMLYKHEDAKVMLQQAKEQFEGMGDRREVAQCLRSLGNISRMLNQYEDAMVMLQQAKEQFEGLDPGVELLNAYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CV92</accession>
    <name>A0A8H5CV92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D9758_006769</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="JAACJM010000085">
        <property type="protein sequence ID" value="KAF5348649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CV92"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="160"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="269"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF5348649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="419" mass="45452" checksum="E39FE718C9951D5C" modified="2022-01-19" version="1">MFGLSRSALLKGVRNTRLSNASVRPASSFAKFNWEDPLNLESLLTEEEIAIRDSAHQYCQENLAPRVIKGWRTEEYDPTVLPEMGKLGLLGPTIKGYGCAGVSNVSYGLIAREIERVDSGYRSTSSVQSSLTMHPINEFGSEEQKSRFLPGMAKGEIVGAFGLTEPNHGSDPASMKTTAEDVDGGFIINGSKTWITNSPVADVFVIWAKCKWDNKIRGFLLEKGMKGLTTPAIKNKVSLRVSLTGSVFMDNVRVSKDALLPGTRSLGSAFSCLNSARFGISWGVMGALEDCVHRAREYALERHQFDRPIASFQLIQKKLADAQSEVALGLLASLQVGRLKDQGLLAPEMINLVKKNNCGKALQHARSVLDILGGNAASDEYHIARHAANLQIANTYEGTNDVHALVLGKAITGIAAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CVU7</accession>
    <name>A0A8H5CVU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_010053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000088">
        <property type="protein sequence ID" value="KAF5348031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CVU7"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5348031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="413" mass="45990" checksum="98DA0FAC933AE383" modified="2022-01-19" version="1">MLSNVIMVLRWYPQPMTSPLSDPILDAGCSSQERFRQWASRHRSQQISVHPAHLHARYSKIWLGRALPEGGELYTLEVSKEHAANVTSYCPILTVGPAHNSMLNMKAEVPYDLISIDVAKYFTETKRLIKSRGVVIRLSIFFPLFALLTVPKIVDNMLFNIPVMSTRFYNHKDIEAVTHRKANCLRHLQRAFITEEMSKVLQENAILADIHLLQNGILDTVCKTSLDNGLPDIAITPAEGKFLQLVAKSIKAKMILEVGTLGGYSTIWLGRALPEDGELLTLEVDENHAKIARENLFLAGLSSKCKVVVGPAHDSMVNMKPEVPFDLILIDADKPSNTKYFKEAKRLVKSGGVIIVDNVVRHGRVADPTLSDPVLEGVRELLEMLKGDQDVEASTIGTVGEKGYDGFLFALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CWQ1</accession>
    <name>A0A8H5CWQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_014231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000084">
        <property type="protein sequence ID" value="KAF5348963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CWQ1"/>
    <dbReference type="OrthoDB" id="3267566at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5348963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19048" checksum="EBEFC6BD45251140" modified="2022-01-19" version="1">MSAVTHNQQVPLITLKTELIGKITGRKIDADALIDSGVEGIIINSHFVQENWLTLLPIKNPFPVQNVDGSKNTMGWVCHYTIQKLRIYSQDNKLYHEETAEFYVTDIRDHNIILSTDWLEEHNPEIDWSFSRMNMVRCPEMCTLEQPPVLNLHTKPKAPKPSTVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CXQ7</accession>
    <name>A0A8H5CXQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000083">
        <property type="protein sequence ID" value="KAF5349051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CXQ7"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5349051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="130" mass="14747" checksum="E3879832CD6AB606" modified="2022-01-19" version="1">MKTDDLDDVFSSLVSDDAYLEPGDELYTLVPQLQHLRLETFSRSPLALEGLVEMIKSRRVFAPGCSPVNHVACLERLVLLSYQVDLRLRQPEDFQALEELGSEGLDLDVSLFWAQGRRVAMLEPSLLHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5CYN1</accession>
    <name>A0A8H5CYN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_012459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000074">
        <property type="protein sequence ID" value="KAF5350391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5CYN1"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5350391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30650" checksum="4F31DEF0AD6DB59F" modified="2022-01-19" version="1">MSTPTQPINVPSLNPNPISHHSSAYSVLSHLHALSLSQERGKGNRGKHFPRLPGFEHLPGDARLGSTEEFVEELVALDEDKALAVYMILRGMGARRVVEAGTSYGVSLIYLLCAVLDNITGETPDAYGSGSNLPPLVVGTELEPAKVAKALAHVKEAFPLSTHDPERYCQVPQILNLLQGDLLQTIPSFFESTSLPDQSIDALLLDIWAPLARPMLELILPKLRRGAVVFLDNSMSSRDRYKDILEFLKGTEDSEGRRLFKCVTLPFEGGLEMCIYEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5D263</accession>
    <name>A0A8H5D263_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_008018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000071">
        <property type="protein sequence ID" value="KAF5351383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5D263"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034446954" description="Fungal lipase-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5351383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="283" mass="30215" checksum="7F316F119EC84925" modified="2022-01-19" version="1">MFLKSFIVLLGVTALVSGSPVNLSTRTIDQATFNDLTFYFQYASSAYADSCASPNGNTLITAFNNTVTDTQGFIARDDNRREIVVALRGSSSTTDFLIDFEILLVPFVSPGVTPPAGSLAHIGFLTAWNSVAAQVLTIVRTQLAAHPGYSLVSTGHSLGGALSSLAGIALQQNFPNTPTRMFTYGQPRTFNPTGALFINQQFGENAFRAVHTTDGIPTIIPTILGYRHHGIEYWQNPDPASAQTTKKCAADGEDPTCSASIPSQGFNQAHDTYFGIDGGTAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DA90</accession>
    <name>A0A8H5DA90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_006413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DA90"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5355508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="113" mass="12340" checksum="58FED461D6610EC5" modified="2022-01-19" version="1">MPVIGARTAGLVVASRLSEDVKTTVCILEVGQNLVETPEMFKDHNASMNDRVERFNTVPQPGIKNRSIYHQRGKTVEGTSSTDDLSNDRGHADDYDGEMLATGEIDVSRSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5DAD1</accession>
    <name>A0A8H5DAD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D9758_006340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5DAD1"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF5355568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="247" mass="27672" checksum="3AE8F4F9F8BDE083" modified="2022-01-19" version="1">MADFFNSSDDIDFDKAASAFPDISLDGEGDIPSIPAVPAASNSNNSFSFDDFDDKPIQPVKVTGDDEIEKFESEFPDIEIPTSPPVFQQQPQQQPQTPSFGAPRPQHASTPILNQPLEEEEPEVIKEWRKKQAEEIAARDEASKARRQETISKAERAIDDFYEEYAAKKERTIRENKDSEQEFLQNLTESLSKGTTWERICELIELQNSQSKTIARTGAGTTELSRFKEVLLRLKREGDAAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5ER22</accession>
    <name>A0A8H5ER22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_019000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000645">
        <property type="protein sequence ID" value="KAF5309327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5ER22"/>
    <dbReference type="OrthoDB" id="3256444at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5309327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="407" mass="46480" checksum="5AE00A0BE844DF9B" modified="2022-01-19" version="1">MVATKKASASTEKQTTVDDHFPTCPPMHPPPERVLPYSDELFKEVAHDWLTATDQPIWALQHPTFHEMIDVASRAPTGVKVKIPDRKVTHQSSSEGKVSTTCDGWQASNDMNTSHSGVTMACTLFKVLHRVGILRKMGWITCDNVSNNDTMLTEFAKLINDHPSQQGMRRWDPDHHHIQAKFDFDGDELPESSRDLIAVIHEIGRKVRSSSKHKHLFKRLQSSEQALLLIDMFVKEFLDKIWLDKTDTRLLHMQDSEWNEIIHLISILMHADEIQQKFSSENDPTLHLAIPLLESLHKKWSVCMKRSRYSELQEPLKAGVAKLKTYYEKTSDSAAYVSLILKRRWIISSVIGTAVYKMSLKFKERYEEIDGSDGSLKLSVQSSVASKQRKGNQAMDLSDDEDDSVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F0L6</accession>
    <name>A0A8H5F0L6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000444">
        <property type="protein sequence ID" value="KAF5318898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F0L6"/>
    <dbReference type="OrthoDB" id="2919606at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5318898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45781" checksum="D22E1DCE273E332B" modified="2022-01-19" version="1">MRKISFPKSVIPPEVLEQIFLHCRRGNSIVTDINDAPFNISQICHQWRDIVLQIPHLWSSFPFIFSTTSSRPSLPVLETVLYRSGSAPLSFSLAYRELGADNLSTLESDSRIFQVFDALLHHISRWETVHLDLPHDTLFPSHFSDILDQTSTLPMLKGLSVHVSERHHNGDENSDSPFPPYSSWLSQFAQLAPSLIAYSQYGDGFDGFPHELEIRTPKLQKLILEKFDAHLEILDTDTSRVNRRRSSRRNHFITFLERSACPLTTLSLRPLLLNEGVLQEALALVSSTLVNLFASLEAASVDSVVLDKGSLLELLTCTEESGKILCPYLKHITLRLCFEASDGQLSGMIESRWWTGADVGQGDPYLGMFAEGLQGSVRMAPGVCLAPKEDVKTKDATEMAGPANLFLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F1I0</accession>
    <name>A0A8H5F1I0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_018909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000426">
        <property type="protein sequence ID" value="KAF5319873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F1I0"/>
    <dbReference type="OrthoDB" id="3252425at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="427"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5319873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="548" mass="61437" checksum="225011B4F58A20DD" modified="2022-01-19" version="1">MYDYPGQLSFAMDVWTFPNHHAFVAWTVHLQYKGKPLVFLLDVVEVPESHSGNILAREFQKTLEQYGLTQKILAFTGDNATSNDTQTTSLSAANNSFHAKSHVRCLNHTINLAAKALIGGVTGNAKDKDADINMDDEEADGDGGDDELPELESVLDVELSESECEGDDEDEEDNEEESIDEVSALTDEEKAVFEREVKKTREALQKIRGLSFSVIHSTTIALPEWKRACGRHELKPCLLPRDVKTHWNSTFDLLKFALEYRAAVDDVTGNKDLAYRKYELTSKEWEILEDLKYVLEVFKRATLSFSDDHKSSISAVIPAMDKIDNMLSTQITSATPHGSTTSTGTRVIHASIKAGLRLAKNLMNHYYSLTDDSAIYCIAMARAVIKQASESTTENSTSQPLSSSNADVFDFMDISVTSHTSPLRDKLSKYLSQALEATKDPLGWWWSKRAIFPVLSQMALDYHSVPATSTPVERVFSQGRQLLVFTRNRLSGFSVRKLLCLGSWSRKDLVSDKVIVNAFVEEDERKSKKSVTAVYFMTVHRGVLYPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F1Y8</accession>
    <name>A0A8H5F1Y8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_018763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000405">
        <property type="protein sequence ID" value="KAF5320577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F1Y8"/>
    <dbReference type="OrthoDB" id="3226582at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5320577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="328" mass="36310" checksum="88690518F77D7F3D" modified="2022-01-19" version="1">MSSTASVSELRLDLKLYLSQSMLESLLPRYFLHGYVHHDPTQRGAGVVARWDFWALVLLFVIATVVTVTDLIANASILYNTFGLGGLHPGLSKLQIHRFNISMQMLAEMGYVFANILADCILIRRCYVVWNSNWKIVILPIFLSIVNNAVGFSAVVMLIDVFLGSLSLEKATQLLNAANKMLEAFFGVNIVSNVLLTFLIAGRIWWIMKQLERMDPDAKGLDDTRRRYRTVIALIVESGLLYPVSVIVFEIILHVVTLSPSLYPLMTTLAGMAPTLIIVRVHLGVSVNTLGEGVNSLNLTAHKGGLRRSGSSVSDGNSIKKRDEEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5F9B3</accession>
    <name>A0A8H5F9B3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000380">
        <property type="protein sequence ID" value="KAF5327958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5F9B3"/>
    <dbReference type="OrthoDB" id="10569469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5327958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="230" mass="25249" checksum="C1700E2B3770E814" modified="2022-01-19" version="1">MILSSPLDYPFIYNASSAPPEAVAKRRVPVELFQKREEDLRVENWVKSQVASNSIMLTAAQAYAQAQSASKSKSYSTKGHRRRRPFSSSNRRHRSQDSFYDQLRLSYNDSSYHSCSGAGAPYLSTISELEEDVESEPYIFYSTSRLASPTSPIDSHVATFVPALQLAAPTPCYPFSYSPSPPSTPSPPSSPSASANSTSTVSPRKTLKNRRGSCSSLSSLSSLESIQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCU6</accession>
    <name>A0A8H5FCU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_018095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000318">
        <property type="protein sequence ID" value="KAF5331783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCU6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5331783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="157" mass="17338" checksum="3A932A3D034A4E84" modified="2022-01-19" version="1">MSTSIQIKPTLTSYDPALYSPIFGPVDETEPVVRVTAVEPPPLPETLKGLKCVYGYELTDELLANCDLFVSRKNEALTSGHLRAVRGEVVYEVAEQVGLFSPIMEFLSGAVRDATDENAVYFADTLHKIPRPCVAEDVLRQLEQKLGTDIKAKWIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FCV0</accession>
    <name>A0A8H5FCV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_016960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000309">
        <property type="protein sequence ID" value="KAF5332365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FCV0"/>
    <dbReference type="OrthoDB" id="3267153at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5332365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="281" mass="32153" checksum="F7F6FCD16271E3A3" modified="2022-01-19" version="1">MTTAYIKVLYSRSLDTSIDMGNNISASNVSAASDLEVRQKYRHFRVLVIGRANAGKTTLLKRVCNTTEEPCIYDEDNRNLLEPTADRGVHNIHRAFAFASNPQFIFHDSPGFEKGGAKELEDVQQFIENRAKATNVEDQLHAVWFCLVTDAARPVLELEERFFREKRFGNVPVIAIFTKFDDLVTQLYGEDKEEAQIYRDATAYVEDKFQKPLAECDYPPSAYLCFEAMQEPNGNHQQQVKELMKKTADSLGDPAWSYYLFRSSKTIWNFASDMQSNTQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FHZ6</accession>
    <name>A0A8H5FHZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_013119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000203">
        <property type="protein sequence ID" value="KAF5337915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FHZ6"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5337915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="217" mass="23529" checksum="00812958A1902F28" modified="2022-01-19" version="1">MSSLSSPLSYEIIKEKIEEQKFNPSQALRDEVDVRLKMQGLVNLLVDEDLLEALAACLARDGGNEDDITAALTKFRELWSNALRKESLNGEIDAFVSLRMCAKLFGPVVVDSSTSAHSFTSDSSSESISSDDSTSLYSTTPSPSSSSASDSPSSSTTSDPSFSSEDAHEHTDDSLGEASSLRVDEAANNNRKSSRQSWTMFRRGANKAFRKIVSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FKZ3</accession>
    <name>A0A8H5FKZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_014981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000177">
        <property type="protein sequence ID" value="KAF5340183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FKZ3"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5340183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="213" mass="23406" checksum="580085E234F96D35" modified="2022-01-19" version="1">MGRWTQYDEDSYRLPEGMERIGYDADTGRYQFRDRASSVWQGQPGSQFGEMTRVSGPPHQGSSSAAGAGVETEDDDDLEATAAPTRMRRDGYQSLPMDTTPMARRQHVNPAAYRQLLPFFLIIGVILLLVYKFIVAPNLGPPSDPCANKENSVSHLVEPGETCWAISQAIGCSLEELEEMNERVDCGRLMPGMVLCVPLKDGSLKGSDSEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FLR7</accession>
    <name>A0A8H5FLR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_013927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000163">
        <property type="protein sequence ID" value="KAF5341474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FLR7"/>
    <dbReference type="OrthoDB" id="3257966at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5341474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="100" mass="10855" checksum="D6D4CBDD05E65AB3" modified="2022-01-19" version="1" fragment="single">TISYTPRLLSAAEPLATQKSRCFMAPPWFSYPSSPEISVVIISHPRNCHQCHAIITVSTYFNHAQRQATKDAGTIAGLDVLRVINEPTTAAALAYGLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQ12</accession>
    <name>A0A8H5FQ12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_011537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000117">
        <property type="protein sequence ID" value="KAF5344909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQ12"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034601018" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5344909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="39379" checksum="BF87B71AA45E024B" modified="2022-01-19" version="1">MVSSLFIALAASSYAAAQSFVSDPLIDKVVPYTAIPYQVDHHTADRGPQAGYNICNSTTEGQSSMCQTAMVNHLDDFCLFAPPEMSTIGDTEGEEVAWCTKPGRGTRLIPEGTLQGVQLVQSPGYIQIAGVIDQSKLNIQTTPELDFGGELDSGGQDGRGNPIGGLVYSNAFPSNGGKNDSFEQSRHWTFFIGGNTFCLKICDDTQPNAAHLCEHIYDRVGCAYNAPNNAQNGTFERCEGEDMMPVGTYVENGQTLTWQQPPEPTTPVPPYTPTPAASSNCVPFASSDLFAQLASVSAPSASGSSAQATGGSGTDTGSGAQPTGGSGSGSGSGSGSGSGTNTRGGSSGSSSQSAAGAANTNGANARGVSLVAGLAGVVFSAMFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FQA8</accession>
    <name>A0A8H5FQA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000114">
        <property type="protein sequence ID" value="KAF5345206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FQA8"/>
    <dbReference type="OrthoDB" id="3270558at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115846" checksum="FB99D84A316D3A67" modified="2022-01-19" version="1">MPPTRGRSRSVSLAALARRASEERGTMLIDLDDSPPTSGCMTPHNDPRLSLSDQVHVAYALDDIHLAKILLLKLKGIEVTSDSDPRIAAVQPEDFDECFLPNGPFMSEEDEEAIKEMQRAERERLRVEHEKQLLRLKEAEEERKRREWEVQCERIWEREKKRIREEKEFVERKREEERKRWEENEKRRLAKEAEVKQRRAQLAAAKAARAAFASPKISYAQLGHHQQSLPDDDLLYNVITPNIRAKRPASSASSSSSSSSHCFPSYSTFKSSPPDHFPGTSISFQDVLASMRGSLFPLECQPERRRSRDSSHSHGNSHDHSHSHSVSVRRKRRDDELLSALLVDVKWEDDEWIRRSKNGAGSGSGKGKEKEKEKEKQSDAGNGKGVTMLGPRPFQPSRQNSTTSVASSNSNSDGCPACSSSPSPISASTSPSTSSSSSTSRSWFSFGSSSSSLSSVSSTSTNITTPSTSPPVKSTTSGPTTASGLRNWLRVRAVTNASISSLHAATPVCTCSTLPSFKPSHLTPIPVSVEDSPLWFPPSSSSRTLPDDASDSVSGGVGAHVPARTRRKSTSRESIISLNSILSITTVDPNNAANTVNTVVSSLNRFVELAKGFQSAYLQATVFAQVNGYDVGDRHRFGSESGEGESDDGEKLEERERERMWREEARRYREFKDGKQMKRLENEVVMSKTKKRKLRPVGYRATKEDVGRMFILNVGGGSSGTNASSVNDSVKVGAGVDPDLVCPRCSKLPASSATDTTSSAKGDSERIHSKSSKSTGDDQDQDNYQWIPLHTLSSPIRPTLNPNRPRTKLPNPLPFPIVFKPETPLTTSPLRRMRMMQQAKEREAERDIREMSLSMYGHSEHGMGGSQGRFARRSSSSPPREYEYTSGSGSGSGSRSRSSSPSSYFLSCSSSSARSRTRNPIPRPRYIANPVYLRVRALNNRISSIEAQRMGLTGGNGSTSGKLREKVVGVGFEEVGRSLLGIGLYGSNVDALVGGVEDGDTDCGVWGEDPDAEVQVEVQFQVPVRVPQIPVQRGRPAVAAGSAGYVRRGRCVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FR72</accession>
    <name>A0A8H5FR72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_013076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000109">
        <property type="protein sequence ID" value="KAF5345703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FR72"/>
    <dbReference type="OrthoDB" id="3270451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="578"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5345703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="959" mass="108190" checksum="C1441EC5536B1B35" modified="2022-01-19" version="1">MDFRADCQKRLGDFKNAQSLWRIKPFLTPFLIIDKLLFVHGLVLDCKILRDSNFPCGSDISGLASLKNDWMDAIWIFKEFEKAEVVRNAQDSQWSNLDSNVTGTWLLHGLTRASQHESLIKAETNLIYAAIHIWWLLEGNLELPANLTDLPISTEVMSRLKLLKVHKGLGNLREQIHDDVYHRLWTHMFEIALGLHMNSGIGWILEVFIENAREWMESSDDPCRWGQTFFDGASSDFLKEHASKISESQTGGSEVHEPAFQSSSRASSAAPGSVNPDDSGLSRKRQASESDVEEGGVGPDCKKRHVVTPSPSPEVSPSLSIITDQDIDIHSQASSPLSPIINEDARLAGSNKAKAPAKSQPSTKKNAYRCKNTTKRSTKAGKFDGITEVKQIQAFRKSSRGKIKTIKPLKPKAIERKKGTFTVPDINGEDWVFEYAPYTNPDNKAQSTPLKDMQALVDVIAEHNKHVKYIDSLAKIRKDNPNQLYIFYLAETDFIALPKEEQQEMEARSLILLHSNPCYKRNSDLSRDMLEHLGDMDDFVEGIDYSMAKEATRDTNPKGDKGKILNLLDLPGPSHDHPFLPDLYTDAHARTQTHSIDAERDDLNLLKFLTWHICGTKDSSSRVHVDGEGLGTQVTLESGEKLWTVLLPPKMDFSAFAKVSPFERFTMAWIKKCKQASFKMIGLRLRPGMTLIMRPNMPHHVVTTASSLCHGAHFYTMSTISDSVYSVYNSAFNRVLGTNIYHHKYADLFVDILGLLYKKLPKGKTYLDDCGRGHTKLSHLPNVLNSDGLNDVLTLINWVDFGRLLFPECYGIRIEDVTPKNIQSRSQEIKGILDLGCAWVLVLLEWLEKSVVIIRNSNGVPVNVLRYRKKYMAKQAKYLLVLADRVAKAIPRDNFEQNLLEDFANDHLFLQELEKLSDADANTLAPLSDFTVKVKSQSDPLEFAELEKKLVKFARKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5FZZ4</accession>
    <name>A0A8H5FZZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5FZZ4"/>
    <dbReference type="OrthoDB" id="3191896at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5355451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="245" mass="26370" checksum="513D7428EB1CC39F" modified="2022-01-19" version="1">MDPPESLEKIFQRVEEESERRAQEEKGLETPQLGDRLKALSPTPSSSSLRTRSRRRGSVSISRFGQLDELTRKPSSDNISIPPKSPTIISTLAAQSTFYKHHGENGSYDSVNSVEEEDERAHAEDAHQVTQVHRIAPRQSISRTVGSLIPRRLSRASRQVIAETNAAGDVVIGVSVEAATVEAEGGAGEAVQATVHAPGLRPKASKASLVSLGSGSGGGWLHKAKSFTGKFRRKSKPVLTTDSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G017</accession>
    <name>A0A8H5G017_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_006060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000057">
        <property type="protein sequence ID" value="KAF5355274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G017"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5355274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="178" mass="19639" checksum="347791C7337BED1E" modified="2022-01-19" version="1">MNPAPLSSRPLDLVYFIFFLTHIPASLLLDFQAIYPASLLPSQLSQLQKWYLEFSGDPLIGGMTGGKGNDELVWFATFVWVELLFQFPVFLLGMRGLWKGSKGIYVLLLAYGASTATTTLPCIFFILKSAAQVTSAQEALLLSSYIPFFLIPFGMAVDMAVRLSKIVSQAGSEKKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G024</accession>
    <name>A0A8H5G024_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000056">
        <property type="protein sequence ID" value="KAF5355541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G024"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5355541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="214" mass="24402" checksum="0E92FDD94A5B062E" modified="2022-01-19" version="1">MIFYSRETFVLFLKLIRQRLRIPSSPWQQIMDRFFEIRDADKSMPMDTYNENDLSAHLHRYGLYTMAYLRPLRKPGLFSKWDSVPMVVRIILSVPRAKLRNVFSGPDVGTPLLQCDIAAHGMQNVFSSLHLAFGKVISVDDARNPRVIIEEDPQGQEGSLPLLVSFIMPSFLLANIPDQEAVNVSFGLRSYPGSLPFVKKLGDMLRIFTGEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5E2</accession>
    <name>A0A8H5G5E2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_007688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000049">
        <property type="protein sequence ID" value="KAF5358663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5E2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034060131" description="Cytochrome P450" evidence="11">
        <location>
            <begin position="17"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5358663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56168" checksum="8FFF55325BA561E7" modified="2022-01-19" version="1">MTFSTTVVILLTTALAVGIFLTRKKGTPLPPGPPGLPIIGNLLDLPSSYDWKTYGEWADKYGPVVSASAFGMTIVVVNSFKHAIELMDKKGTKYSSRPRPTMPVKLMGWENAMAFTEYGQRFRSYRKTFHNELGSTVSLKNYWPQEENHAKHFVKLVLESPERLFDHCFQHAGAIILRVAYGYKAKDRDDEFIRAGNNAMESFNEGCSPSRFMVNQLPILQYIPEWVPGAGFQKTARLWRPLYGLMVKIPFDFVKQQMAAGTAEESFTRNLLKTGLSPEEEDILMHAAGSMFGGGGETTAITVHMFFLMMCLHPEIQKRAHEEMDRVVGRGRLPTFEDRENLPYLESLVKEVMRFHPSVPDGLPHATTEDDYHEGYFIPKGSLVISNIWKMTRDAEVYHDPEVFNPDRFLGPKPEPDPREIVFGFGRRICPGRFLAEISLYITLAMCVAAFNVTPVTEGGKPVFPEYQPEGGPVSRLRPFECVISPRDPEIIAAVSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G5U7</accession>
    <name>A0A8H5G5U7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_008525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000048">
        <property type="protein sequence ID" value="KAF5358830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G5U7"/>
    <dbReference type="OrthoDB" id="2977752at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5358830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="27335" checksum="22176FBF3FFF9EFE" modified="2022-01-19" version="1">MRYTYRLFQQILQLIQRHGLNTRQLHDLAGWTVVVTLALKTGNVQAKDNPVNTSLWTPQPSMSTTYKTSPPIPSQELLDRNLKYAEGHQPKVGDANFGHMPDTAIICCQDCRLNPTKQLGLADFDTAIIRNAAGAVTELTRSILIAQRWGTKHFVVIKHSDCGYFQITGKHLIIEDFKARAKDPNAIDAVVDKLLDLDPPKLSVDDLVLHDVNYLKESPLIFPETKITGWVFDDHTGKIRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G7Y0</accession>
    <name>A0A8H5G7Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_007616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G7Y0"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5360003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="308" mass="33801" checksum="C6D9B6FF846D8959" modified="2022-01-19" version="1">MVEERVAINICVVGASGLIGLRHTQHCLSEPLVNLSCTVDITAPGTAAAGKLKDELVEELSGVPHFTTINEMFQARTEGNIQVDGAIIATPNATHVELGLKMVRNGIDVLVEKPLSTSVDSARVLVEEVERLGRKIAVGHHRRFNPYTIQAKRMFAEGKLGQIQGVWTCLKPLSYFNSPATSWRKTPGNGGVILINLIHEVDLLRYLCGDIIKVYCQQGKSTRGFEIEETDAVASPHNWEGATGENPTMPYTGETVYTFFGTKGTLSIPQLKLHHYAQSVSDSGCWTDPITTDPYPQFDQTTLPLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5G844</accession>
    <name>A0A8H5G844_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_007628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000045">
        <property type="protein sequence ID" value="KAF5360041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5G844"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5360041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="64" mass="6911" checksum="74940CD52507D1C5" modified="2022-01-19" version="1">MYSINGVLALRFIVVPGFYGVGIVLVIYHLLVDETNTRLPTISDLTDNITGAVAVMRRLSCGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAC4</accession>
    <name>A0A8H5GAC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAC4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="652" mass="64736" checksum="65441F3CF1909511" modified="2022-01-19" version="1">MTLVKGIKINNTLKDDDRGREFPTPTNPDANADAAKMAGLVTPIPFIEFVHYEPRNPQEDTSTSSSTTDSTTDSTTTSTTSTTSSTTSSTPSSTTTSTSSTTSSTSSSTSSTSSTSSTSSTSSTSSTSSSTSSTSSSTSSSSSSSSTTTLITTGSGGQTTTVVTVVTPSLTGTGSGVGPSQTKESDNSGFFHNTAAVAGTFTAVGLVSLVALILIITTTIRKRRAKAWDREIAEAAREARATGTVGVPREYLDEDDGDPHGYGGAGYAAGGYETGYGSGSGGAGAGPGGAAGYGSEAGSHGTYGAYGQPPMGGRGEEMYQMRDMGGGGAAAAGLGAAAGAAGIGVARARSGRNGPGNSPVHQDSNYTSTTTPSNTNSNGNGENPYSTNFNDPNGYYSYPSYGDYTDPNYHHQAGLGGGGVGGEGPYPAFLTPGAMQQQQQRGFGVPQSVLDAAGLGVGAGAGAGAAASGPPPMPHSASSGTGGSTTALSPSPSGLGSAGSGYGSASGGSATASTTVLSGGGGGSTEKESYAAHYAKPIGSSHPGSSEGHGRGYDDPYGGMSMGEGKDRDAGLAYDDSDRGHPQQTQRLSLTPPPGSDPYDHHNEGNHSQQLPNPFGRPIESESEDDEDDDGYGGSGSKHGHGGGRVLRVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAF5</accession>
    <name>A0A8H5GAF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_009068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAF5"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5361170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="429" mass="45788" checksum="D41FFF273443939B" modified="2022-01-19" version="1">MTTQSGLNCKLAIGAIRIAECCQLGLIRGSQCEEVSSPTTTPIKVAPRPNEASILGGIFKSEFGGRGRATAAVPTSKPGEESASSSSSSPPQINPPVTEGASSSSPSLQTMSVSDPILPSSTTSPKPSVTGGARSLPSQTMSVSDPILPSPTTSANPPITGGAGSSPSFQIMSVSPPILTSPTTSANPPVTEDAGSSSSSPKLNIILPSVICSLVLLVIIFVIMSCCYHRTKRPRSTTMSDVVRDAAEPSLSDPNIIHPYDLKIDDQVLQPHVPELFPGESTQTRPNDLDSIIVGRRGIFERLLWRNGTNHSELPRPYELKGDLLPLASQDAALTSKTQPNRASISPSPSISRPRPRSVAQTESTGRQIRLREKADALRSQVSGYERDTLVARDEEIRRLREHIQILEIQDNSHWARGLTDDPPPSYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GAH5</accession>
    <name>A0A8H5GAH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000040">
        <property type="protein sequence ID" value="KAF5361399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GAH5"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="70"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="467" mass="51279" checksum="285B7F23C65188C5" modified="2022-01-19" version="1">MGFSNASHTSSLSILTFQSTYLHFTNPHTFDLREISAMNSLTVILALYCTCVQTYWLMGANNVLTTQRIDPILTPGIVSTHVHSVLGGSNFGLNVTTSALLRSECTSIPIIEDKSNYWFPHLYFQKNDGSFESVVGNAVMLVQYDVCHQIYFLQDTSLLDDLQDYLFSDKPNSTTPFPEDFRMISGDPTLRTLDPSSFAQQAITFLCLDFSGQSTRFNELPVNKNCPSGIRSQINFPSCWDGVNVDSDDHRSHVAFLSTGPDNGTCADPRFPVTLPRIFMEVYWITQDFDKQRDEALTPSQPFVFSNGDPTGYGYHADFFNGWEPDVLQRALTSCTCNPYGDPSCCAAQGIFTLNQSSHCYISNIVDEPVLGNLTTLPGANPVQAPCYENYIASSIPAILDPVYVSSTSASATNPSGTVAIPATTIDVTQTAVGTCIWTGDAKRGKTSPILSIVLLVLTWTIQDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGG0</accession>
    <name>A0A8H5GGG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_010708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000033">
        <property type="protein sequence ID" value="KAF5364467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGG0"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5364467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="198" mass="23038" checksum="8EBC402228392899" modified="2022-01-19" version="1">MSAVTHNQQVPLITLKTELIGKITSTKIDGEALIDSGAEGIIINSRFTQENCLTLFPIKNPFPVRNVDGSENTMGWVRYYTIQKLHIYSQDRRSYHEEMAEFYVTDIGDHDIILGTNWLEEHNPEVDWSFSRVDMVRCPETCMLEQPPVLNLHTKPKSPKLTIIDPQTNHKDYQVRWSEPIRRFKPIAWPKIAVRKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GGN4</accession>
    <name>A0A8H5GGN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GGN4"/>
    <dbReference type="OrthoDB" id="3234968at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034757890" evidence="3">
        <location>
            <begin position="29"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="344" mass="37437" checksum="B102B0B7BC3E290D" modified="2022-01-19" version="1">MARSFRSRTIYMALITLTLLGLSDHTQAKHDKTVGHKDSSISYSGTWQEDNHNGGSEMWSNDPEAKATYKFTGKSKSFIIFWFKDHIANPCQIPHLSGVAISYQVHLYPGNLPAGALLSVDNNTPDEVVLFDPNADDYGKNLKKVWSADNLQNGEHTLHVAYWDADLNDNADDDDDDDDHNDEDDTTYLTLDTLVVTVLDNSDIHSSSSSSSASSTSTSASATESATSTPSAAPDTTRRDTASRVLKYTGIAIGGLVALGLLATIIPYCYRRRLANQTAHNFVPVKGGSMGTAAVSQQAAMRSYDYSSVSRSDVEENPFIAPGETAYDGTPYHHHPQGATRYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GH20</accession>
    <name>A0A8H5GH20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_005532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GH20"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5364660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="253" mass="27197" checksum="ADC173D688258F74" modified="2022-01-19" version="1">MSLGTVPVRRRPSLAIVVVRKVTSLENAPKAPTLVAEVSAAVDPDPSATVAERLAISLAHAPKLLPVEEEEEDTWEDLTVKRLATLAVVLVTYPGTVSRARNVTTATRLDTSPEIAPSPKRRPAITAAVRTGHMAAACPQRNTPTCYNCGEKGHLSTECTSKPKCHRCGEIGHISAKCPSPRRDVPYTGGFMMRGPCRKCGEHGHIARDCTRVRCYNCNGTGHISSKCPEPQRKVCYKCGSPGHIASRCPDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIB1</accession>
    <name>A0A8H5GIB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_003286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000026">
        <property type="protein sequence ID" value="KAF5365629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIB1"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="280" mass="31494" checksum="7084752BD232E4D1" modified="2022-01-19" version="1">MTVLVVKMNVFKHTEGVFKSPLSLFGSACSPVHPITPLAMSQESNSYRYAEFSAPVSRKKRKNAKSKVPLLTLLQNSRDDLKKDEWSTRTHFDALDKKSWKSTARVVCLGLGSPSNSPIPRAQLGFLLDMCDVLKIDFEQVTVYDPVFTEQDHCLLKGLEFRTPLSGEDLGVTADDPTIFFMPHCDIELYENVLRKNWTGERLSNLILVSNRLEDYVENNSVDKLESTAPAVLRIVPFLSSQSLPPSKIWPAAFNNTSVQYIPANPDWFSEIPLLPSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GIK1</accession>
    <name>A0A8H5GIK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_010851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000027">
        <property type="protein sequence ID" value="KAF5365429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GIK1"/>
    <dbReference type="OrthoDB" id="3026773at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034270533" evidence="2">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5365429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="243" mass="25972" checksum="2C4769D9E46BC76C" modified="2022-01-19" version="1">MKVTRKNTMPAQSSLLKSFLISTTLAWITQASTVTFKAVDIPPNNTGGISSLSVSSTISIFVSYSEAGVKSDSDGSETTYIREVVMSEQYLPDGRVITLPTPISAEGTVFKIIFRTYLTVFLATLVQSSGGFWISQVATGGEYEILTTGSTTSFSPLGTATVTDTQYQACSLESDGRYACVQDLPQLGRTQRTLSYTATASDAVFTNVGELKEDNHAVGSMMTMAWQAVVVLSAIVIGGMLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GJT1</accession>
    <name>A0A8H5GJT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GJT1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5366273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="411" mass="43920" checksum="315363FD44960595" modified="2022-01-19" version="1">MPNLKTIAGAAAIACAAVAYANQSKIEDAPFQLPPQAVFIDPRSFAVMGPNATFRENTFDNTFFNPTATTPPFFQVFDEAFLQILGPNATIRQVAVNDTFAFAHEAPIYNKATDELFFASNDGGALGMSDLNHNNLYGKISMKDVDAAFAANESAINVPVTELDLPDTIQMINGGTGPYNDSLLLITSGRGPLPPSIALVNPLPPNNATVLLDNYYGRQFNSLNDIKVHPTNGKIFFTDTIYGFVNEFRPAPLMPNQVYRFDPDTSAVKVVADGFDKCNGIAFSSDGKTAYISDTGVAGSVLVNNQTEPATIYVFDVDPVSHVFKNRRILAFIDAGIPDGIEVDTQGNVYTGTADGAQVFNPDGVLLGKFFLGTTSANMVFAGPGRLVILAETKIFVAEIAANGFSLGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GK82</accession>
    <name>A0A8H5GK82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LanC-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_005798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000024">
        <property type="protein sequence ID" value="KAF5366296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GK82"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5366296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61441" checksum="097927854F2AFE79" modified="2022-01-19" version="1">MSTRSPRFIPHPDSLSNSLNVDELWVTLVRDLEKVQRETMQRPDPKLLLSAYVGLGGTVMMSRIVASFSDLGPPHDTILRSTLSRALSSTNIEQMVRTLYRGLQAAQWYPQIGSKISFLETPVGIATIILLYVIESGNNIDSNTGGKKIWEVCTEILQNGFQVLSKESRGSMTKDDANMDVDADTDDGCEVLYGRAGFLYALLRLRASVYRCVPRPHEGTDEKSRKLWNLISDENLRMAIHSIVERGRVGAKFFSSETGASASPPLMWSWHHKRYLGGAHGVAGILHVLLMCPTQLISAYVAEMLGTIEWLIDLQDKEGNWPSSFGKSRDHENDLVQWCHGAPGLLILFSTLIRRCHTNPSTFSLTPAFASSLISALHNAEVLVYTRGFLRKGVGLCHGVSGSVYALLAASDAVALLQSNPEPPPGQQQQQQPQTVLQIDRHDEFSRAYFLHAVHLAYLATGYRALEVQGEMSQPDRPWSLYEGLGGMCCAWAEVYDRLSTTGRNLAQTQGRTGANGQVGSTEGGGSESTTNLNLNPRLQWARSRSGMPGYDDMIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GNK5</accession>
    <name>A0A8H5GNK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D9758_004381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000017">
        <property type="protein sequence ID" value="KAF5368099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GNK5"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF5368099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="867" mass="99840" checksum="DAA8DCEDF34CF1A1" modified="2022-01-19" version="1">MSFITNLIHRIPEGLDHARDEIVGRLNPNRRHDDPEEQKADAIRAEINASHRFQSFAEERTNNFVKWHVDGHDYMWALSEMLENAKECIFILDWWLTPELYLRRPPAKQEQWRLDRVLKRKAEQGVKVYVVVYKEVTQTMSMSSKHTKWALTELNPNIQCIRHPDHIGSKDTVEFWSHHEKVVVVDNHFACIGGLDLCFGRWDTHTHPLADVHPTAFSDTLFPGQDFNNARIMDFQNVGDYASNQLSLLESARMPWHDVHMTLTGPCVLDIVQHFVERWNEIKKRKYRESSDVDWLSFPHNVQASPNEAVARHPQRETWSGMGRRYRQRWHRMAHGDSGPHHHDDDDDYEDHEGYYKGPNPATCRVQVVRSVSDWSHGVLTEHSIQNAYIQLINEANHYIYIENQFFISATVDGDQVTNRIAQALVGRVVAAAKDDRKFQIVIAIPEVPGFSGNIKDETSLKIIMAAQYRTINRGGNSIYELIRKEGIEPMDYIRFYHLRAYDRINSPTSFIRNVEERCGISFQSATVALARLWLGDQAFKTDSGDEVEVKINANIETSEGLGQTERTRDKKDKDKEPVAVKVPASEEEAKEIIRKFERAAREVRGLDLDGDGHDGKVSDNVVQHMLEDTTALAQEQWDGSDEEELASYVSELLYIHSKVMIVDDRRVIMGSANINDRSQKGDGDSEIALVVEDNDMIKSKMNGEDYMAARFAATLRRQLYKEHLGLIPPQNPNHSSRHPTSFMRPAPHPNDDETDSREDQLVADPLSEETTNLWRDTARKNREIFTEIFRPVPTNLVRDWKAYENYVPKVRTGHVVPDVTLERVKSRLAEVKGALVECPLDFLIDEHEFVQGPEWKGLNPTLPIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GPK7</accession>
    <name>A0A8H5GPK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="9">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="9">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D9758_002340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="9"/>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GPK7"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF5368560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="385" mass="41506" checksum="4E255AAE62FA30D9" modified="2022-01-19" version="1">MLSTLRKAGSLARTASAGQRRFLSIHEYQSVNLLNSYGIPTPKSIPAKSAQEAFDVAQSFGHNRLVIKAQVLAGGRGKGHFETGLQGGVHVVDSPEQAKEYAAKMLGSKLITKQTGARGVVLVASNQGGMNIEEVAAKDPSAIVTTPINYETGLTRPEAVEIAKKLGFKPESIDEAADIFVNLYRIFKEKDATQIEINPLAETKDGAVLCMDAKFGFDDNAEFRQKDIFSLRDISQEEPSEVEAQKYNLNFIKLDGSIGCLVNGAGLAMATMDVLSLHGGEPANFLDVGGGATPDTVKKAFEILLTDPKVKTIFINIFGGIMRCDYIAEGVIKATKELDLKIPLVVRLKGTKEQEAKDMIKESGLKIVAFDSLDEAAERAVNLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GQA5</accession>
    <name>A0A8H5GQA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_002928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000014">
        <property type="protein sequence ID" value="KAF5369059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GQA5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF646">
        <property type="entry name" value="HAEMOLYSIN SECRETION ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="415"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5369059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="699" mass="77917" checksum="1E949039477B3F77" modified="2022-01-19" version="1">MPNLPEDSKPDPKASSTNNLEDSLLVKVVGVYTLYREKKKQRGSLRSVCVQFCEKWIEYLKAITRLVWEVYTLAPVLFLLSVLGQLVQSTEDLILLHYETRIMRIIEIGISKGTVDTNAVVQAVGARILCVVGIKVLYILRSYAWSAVFNQEFFSTLTITCSVVGKLGLDMSMLAGNLKDDNISAGSVWYTVEALLSTTCRLFGLLSQLGFVYHLGRSSNYGTLFIFLCLAKPLLSRRFIFRMYAEPRIVETTNPHFIRMKSLEALAEKQFRSDIMSGNIYRKAQAALGDTPIIEPHMVLYTLGEESFMQAFFEAADDLPMVFCAALVIINPSKTSLSTIFSLRQSANSLKTSFFRMFYEISNLESKADVAVQLYEMEKKLAQTAVKDGELVYGVPEFETESKDVEKSVSRGMGIEVRDVSFSYPGGEANAKALDNASFSIAPGQLVVIVGANGSGKSTFIKLLSRLYNASSGEILVDGVDITKYKLGSIRQAMAMLTQDHHLYPLSIKENIGLGFAERMYDDEMVMDAAKKGGADTVVKRLAERMDTVLDPKGFQTAYKVLPTDKTALGEKLKSLKKTVDVSGGEKQRLVAQVARTFMRFNSGKVNLVAVDEPSSALDPEAELELFNNIRNMREGKTVIFVTHRFGHLTKHADLILCMDGGRVIESGTHTELMTMEGQYFKMYNIQAQAFEPKQEKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GR10</accession>
    <name>A0A8H5GR10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_002489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000013">
        <property type="protein sequence ID" value="KAF5369434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GR10"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5369434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="619" mass="67744" checksum="7C15BA2F8569454A" modified="2022-01-19" version="1">MDKAIRRQVRATEQQRLALEEFFEKHPDANRNSIQDLGTSIGLTEKWIQGWRQRKRKRDQDNLRENTTEPRMPRLTVSSASSDGLCVKSEYQEPTIPPAPPEPPKKKTKKNKKPRKTPAPKTKQTLVTVKSETIDAPLPAPAADAKPSAPNSSPALVADVASHPVDDQTREPRRVYPHASQLASLAHPSTTSAPTIHPVVNTSLVHRTAALPAEMSDFANHSSFLCKTAATPDSTYISQRLPMPFEPSPFTSYPGAAPPISSVYVTRALPYVNNPSTRSLSNFHGSADTSLSHNTAINIPTHYRTFEPNPALYSNQQPPAFAGTSFLEQNAPMNPAQTPVRHLDVVAPLFLRGMSDADLMSAMTEQLLDERLVEQDPFQAAMGLVFLTNMGLGPAGLSRPWLKYSLHCHSSKLVLSMASQASRRFLSSLRVTARPTRSNVSLRGLRASRRGMSSTTEAAKKSSDMPWIIGSALVFGPATLYLLSPSSRKTAPHQQHNDKHEHEEQQHEAASIKMKDDEGKEADVTESVKAAESEDVPKAEQPATEKKEEKEEESAGDKPKVAASPEEAQKEEPPVPKDPAGDKGEPGPTDQSIPKEASTKGESPKSVDEKVEGQKKNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSA0</accession>
    <name>A0A8H5GSA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_001222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSA0"/>
    <dbReference type="OrthoDB" id="3132420at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="183" mass="20888" checksum="E1A1CF0B9442B32B" modified="2022-01-19" version="1">MKDSQITMTSSGFTLHFSFPDTDSSENMSRTFKIYKVGDGATDASTELYRFHHPDTGLKTGLTTFHRQNLQTNIFEIAGQIDWLATYNCTVSFGVDEVHVQDLRKRKNSGSRSRRFKASGAEYKWKIAENDEGLLCVDSSGKNVATWSHQNHNLWISEKGELVLDRITVTCFLNLWFKQHGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSF4</accession>
    <name>A0A8H5GSF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_006911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSF4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5370398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="226" mass="24358" checksum="DB7CAFAEB20F0010" modified="2022-01-19" version="1">MQSLSGFLRKIFRSTRPVKDRGSDPEISGNNDVYSVPNPPVATDPWTRRPRPPPPPFPQPSTPTDDYISDVGQVRSAGPLTERAPPPLPPPPPPPFPQPSSPTNDSISDAEQVQSEPELRTHNPDDGNAQARNQPDRYRQATSSSSPTAAIARHDTFASKLSSVDTLPSYRSRPTSLAASLPAYRLSSVVRAQPPLPSLPSLYRFSGLETTVLGASESGRDAGEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GSW9</accession>
    <name>A0A8H5GSW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_006947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000011">
        <property type="protein sequence ID" value="KAF5370364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GSW9"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="160" mass="18203" checksum="D38202C375781F46" modified="2022-01-19" version="1">MFTALMRAISGTCYASVLHVSDNCSHHRHAFLNRWDTVGLNWAYAFEKIIFRYRFVHNSVVAREIEDEDSGGDGEYDYDTPTDPYLTLTHPYNNSIIHLNVNPIHLNRSHTTNVVNAPNVPHAPPRFDENPNPHQNLADQTQINRLLSPSLLRVAGLWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GU58</accession>
    <name>A0A8H5GU58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D9758_004192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GU58"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF5371126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="165" mass="19287" checksum="12AFFB37BF032AB8" modified="2022-01-19" version="1">MYGSSAVSKAKRRTHARPELSDEQKKEIQEAFELFDTDKDGRIDYHELKVALRALGFDMKKAEVLKLLRDNDKLGQGLMDFEDFARIMSQKILERDPMEEIRRAFQLFDDDHTGKISLRNLRRVAKEIGDRLEDDELQAMIDEFDLDQDGEINEQEFIAIMMDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GUQ2</accession>
    <name>A0A8H5GUQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GUQ2"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF5">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5371245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="158" mass="17576" checksum="EBF858CAD03C4A1F" modified="2022-01-19" version="1">MPPRKKTTKRKDNFRSAPPRRKLATQKDLKNLLELLKKQLGFKPHDFQVHAIQAQPLGKDVVVHAGTGSGKTVIAAGPHLHNPKSGVTLFISPLIGLQNEQDQVQTFSNQFKLKAVAVNSQHGGCKPELLQSIIRCEYNIVILSPEMLLLKQFVETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXI4</accession>
    <name>A0A8H5GXI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXI4"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5372963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="321" mass="32236" checksum="A1E935C06E5CA92F" modified="2022-01-19" version="1">MPLFGPKLNFGRKNVHAAYARKDLERSGLISRADDGTVTQKDDGSTSNPKSDAGGGSDGTPHAASGSSSQSSAAPQQTSTDSSQPHSAQQPEPTPSTSASSPQPTGDAGSNAAGSVTSPSDGAKQASPVGDTGTSPASTDSTASSGSSASNSISTGVGSSSSSVPASSGPDSTSSPAKDSSSNPAPSASSTGKDSSPNAAVPSSPHSNVPDVASNPTLQNVDSASTNTPSLPSSSHRNNAVAITSGIVSIVMLLAIGGFFFLRRKVHQTKRSAQAVEFLFVNPSHSFQRLNSPPETRLPSSSPSFQYSAEPRFAQNFLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GXN3</accession>
    <name>A0A8H5GXN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5373129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GXN3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="801"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5373129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="933" mass="100965" checksum="B5492699DFF0A17D" modified="2022-01-19" version="1">MANPSVSVHQLYKRLETVGKGAYGSVSKGVDLRDGSVVALKIINLDTADDDVGDIQREVALLTQLRDAPNITEYYGCYMDGPRVWIVMEFAQGGSVLALMKASKDGCLEEKYISVIIREVLISLSYLHKVPVIHRDMKAANVLVTETGKVMICDFGVSALLSTTSSKRNTLTGTPYWMAPEVVQAVPAYDTKADIWSLGIMIYEMVKGGPPHSHLDKFKVMDLIPRAKPPRLMENEAGKDMRDFMALCLKESPTERLPADELLKSKWMKSVAKVPVSLLQEPVRRLQQAGPRESLAGPLDWEMEELNPAFEDDNLWEFDTVRGRSRLSQLTGDGYTEQGLRDNSLQAQATIRAAPSTPLPSSLRGLFGDDDSQNTFHPPAFPFSIPNTPSLPDSSTISPTGADKATKKPQPPDEEEFTKTSTFVFPRRARPRPNLSTSVSDKEPSPSSPTESTDRKVEDISPASDQSDETPVQSLANIRDGHSARDPSIVSSNGTAEISSHQESPAWMTMSTPEIPPPSSFTRAITRKRSQSNVDDSSPPDHTAKSSLASRRDFHMNLTSDHGFQFPPPLSSSSATLGATQPLQLSKPRISPSPSPIHTSSQSSQRSPSPSNHQSTYSLDTPSSTRRFISTSSAPKSPQITRTRSATAIPPEAKTSPYPSPFPTPVMPYSNASPRDDLLLPPVKPFAEPLGRRTRSGSGSDASIHGKNLNLGTPGLKDVLKIPSLSSEHHLGINDLLPPSPSAMVNPRLFSPTPSHLNPTFVSSTPTTAHSAGPSFGFSIPRTSSPSPFDHIRSAPVDGPSSISSSHQTKISHKPSTSLASISSSTSSSTLPAMRPLDYSALVSADVTNAELARTIDDLAKCLSVVEAGLTGMLDTIFVRDAIEEEQEETLYDEDGFGDDSQILSDSTESYFPTPNTTLVNGHGGEYSMLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5GZ37</accession>
    <name>A0A8H5GZ37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D9758_000837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAACJM010000003">
        <property type="protein sequence ID" value="KAF5373803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5GZ37"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="462"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF5373803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="1267" mass="145401" checksum="A63A22860CB62FE0" modified="2022-01-19" version="1">MKLLHRENRASSLSRGLQAYTPLLLLPPTFLLHLTMEICIRYLPHQVNEWDLTRALALVLHSEPFLQRTEDERFQKINFAVKVNPNKAGGLRNDGTGVLTLPTPSIGYRFLDYVKDTPFKMDTRKIKFFPSREKPGSSFALSLQKSAYIDPDIEEQRQEKIANLQDAIRVDIIQFGIYFRRPSRPGEPLKSREYSTEWQRDYAKESTAWLRFEYDHKLMRIELGNPMTEQIGSTIAITFGSIQRIAIGYDGGCPYVCFDTSTPPVFEETEFNRALVGDDHIDNQRYKHRIGSLHPGHEQVAPYAQKLRIILYNESRYDVIDKFKGYCKIAELSDSLVLDCRRYAKFHIEAGKREFFIPKRLYKLRLQFKQFDWSIAFQLEALLHNCLLHTEELEELLPRVKNLCKDHLPAFAAELLRKYGEQLQARSPQEDPIKCFERARSFVSSPLALSPGNFSCYHVTFAPTRLILEGPNPVQSNRIIRLYSGFEDHFIRVDFRDEDRLSYRWEREVDGSTFIERRVGETLKNGFELAGRYFEFLAYSFSALREHAVWFMNPFMHPEKGLVNAESIRRSIGNFEGTTLLKQPSKYAARLAQAFTATDRSVSIRRDEWEVVPDIENKTSVFTDGVGTIAQALANRVWEALCEGRHDQGRMVVQPSAYQIRFLGFKGVVSVDKELDRGPIKMRLRESMKKFESDIPEEADIEIALAFERPIVSYLNRPLVTVLEDRKVRKEAFLSLQREAVAQVFTVDDDISTCATVLRSLSYGRQYYLAWILEQLRKLGCDFQQRPGITSVDDTFFQELRAVARMATLRDMKHSARIPIPNSYLLVGVADEGPVYQNAGCKNVYILQEGHIYACVQKSPDDEPEWLEGSCTISRSPVAHPGDVQRVHAIGKPPQNMMCLFGHLKNVVVLPTVGKRSLASCLGGGDLDGDLYQVIMHPDLLPTKNADAAAYTSIGTHTLERECNVNDIVNFIVEYINSDVLGLLSDRLLVIADQSKEGTFDRKCTYLAELCSQAVDYPKQGIAVDLDKNKLPSFYMRPKPDWHAAEVVKPRKTGQILLLPIRSSTRAHVPRDIPCSARDRKGSEPFPENQAEKPKPPPPMQDPISIVLKKKLKQVLSSDYIDPNGRDPEIERIFRKYTDELRYVCATHTVSNTPGVRLLETEAVMGTILASCTQKRWRKDRIVRMKLHVGELVADVKREFQRDPTANIKEKDREEYLFILERAWYCWDYSRRQRTREDQLEFGANSFGLIALGSIFYCLDELSKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0B1</accession>
    <name>A0A8H5H0B1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_004524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0B1"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="84" mass="9315" checksum="BCE4E2E0275F09CB" modified="2022-01-19" version="1">MRLWFCYELATDPEYQGLGCVTELVQHVYEIATEAGGFISLATAVPLNLKKYLSPRMGFHERGSFTNGSPIAILTSHVLVRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H0Z4</accession>
    <name>A0A8H5H0Z4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H0Z4"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="199" mass="23241" checksum="1FC7FD0AC17B3113" modified="2022-01-19" version="1">MTSSREEVQRVSLESAEDWKRIKSAYTDAVLSRLEDEGVPSGSPIIKYMQRFIDQSLTSAQPNLRINGRNFEALDQQDEPDIEQFDEALDRRVWSLADNRLAWHKEIANKRRTIPQEVERTLHKLFEQEKVEERDSELQEDDSDEQMIEDYGPNQQADPTSGFHKTSAWAEELSQSIPSQQERSERFESVAEDVKRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5H1E0</accession>
    <name>A0A8H5H1E0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_000487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5H1E0"/>
    <dbReference type="OrthoDB" id="3192267at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5374906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="142" mass="15554" checksum="6E03FA5CF5B5509F" modified="2022-01-19" version="1">MNPPHYILFASASSSSLGHPAIQYHYADDSPLSILPQYPDEHVLLLNYDPNSATSPSVVSTSRNIAVTGVRVEEAPGAAAAEEKHNDRMYIIETVPNPVETKHSSQSDPQSPQAILNQFKQRNTIIRRALQYPGVPHVSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LHJ2</accession>
    <name>A0A8H5LHJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_005884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="JAACJM010000052">
        <property type="protein sequence ID" value="KAF5357354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LHJ2"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5357354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="349" mass="38943" checksum="5435DDBD52EB0B60" modified="2022-01-19" version="1">MFPPPTKPQDADGSIRLTDNDAALARLSAVQKNYLSDLFIRFLVPRPHLQAPRPPLINIGTFVRTTAIDDLVHQWLSLSSNAGKKCQIVSLGAGSDTRFWRLATGPLKDQISAYMELDFPEVTTKKAMAIKKSKDLSAVLGDPNDIKLAQGGICLHAPKYHLLGTDLRKPMSENLGPLVSETTPLLDPSLPTLILSECVLCYMSVAESSAVLQWFREYFKNSVLGCVVYEMFGLEDAFGRVMVNNLKSRNVTLPGAEYSSDVNVLPKRYLDIGFTTSRALTLREIRRAYVEPEELERISGLEMLDEVEELDLVLQHYAIISSLAVSSQEGLSLWEQWGLRVKERKSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL58</accession>
    <name>A0A8H5LL58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_009017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000042">
        <property type="protein sequence ID" value="KAF5361148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL58"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="170" mass="17296" checksum="090B7D934113415C" modified="2022-01-19" version="1">MDTKGPGSQSNSRSPSSGPPPAQQEQQSSKPGSRQASRSRTRARSRNPRSASVSSADDSDAAPARGPQPRRRGQRRGQGQGQGGGLPGIGEIDDVGNQVGQVANTGKGAVDSVGNAVGGLTGGGKQVQGGGDDEGDSGDKPLKLRLDLNLDVAVELKARVHGDLTLSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LL97</accession>
    <name>A0A8H5LL97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_010288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000041">
        <property type="protein sequence ID" value="KAF5361298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LL97"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5361298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="695" mass="74852" checksum="A01C28CA766ADB3B" modified="2022-01-19" version="1">MSSNVLMTTVPVFAGVDFNIWADILVAWLQATGLSSVLRSDRPDDAEVSTASPLSAEDAAAQSEAITAAQKKQADWDEKNDKAMGSIKLRLSPPVRQKTLGMTTAKEIWDFLKKTYGKPGVSAIYTDFKRATSITIPNDANPSAAIELIRMHFDRVSAYGIPTDGTSTTSVTKVANFLIVMFIISKLPPRYEYLINQYTQYTLEEVDTANLDVLQSEIVNIWESRQGAFKGPSGKAHANRLSAVKRKDGNPSFQQQQQQRPSGSSSGANGASGSNGNNKGKGKGKGKGKANFRRGGRAGKFEQAKRQGQAHLVHDDMSPMMHTVTVVDTPAAVDTRTKRAINLARDIGARPSGETVATLEDVVMSHTDPSSFTSLTPAPRPKRTLTERIYWNNLQSSSDGWGDAGNWNGWNGEYPEIQTSSDADMACAQGEDASWNKDTLVNTSELGSVFGTTTTESGAKVSQDIRTPVPLIDRIAADPAAEMMECAIHLGERFQNPEDPLHIYGEPLRAALNTVAPTGTSGTLSLVQRLAAVRSEMPSGSQPAPPNGMTTQSLPSSRVASPTPGTTSTGWEWLTPHLQNEDGRYDELIDWQRDATIGLGGMELPSRAPTPSSMPELRSMSPSLSETSDLEYMSTPPSIGRMSLPTSPVEDTASYGIPSPRPSTPVMVTVNAANNYGWSLDSEPNGMDNGYLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LMX8</accession>
    <name>A0A8H5LMX8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_012629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000035">
        <property type="protein sequence ID" value="KAF5363081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LMX8"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5363081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="221" mass="24759" checksum="25F9CCA956F1BBE5" modified="2022-01-19" version="1">MATNNQVVSYNSSSHALTIRPAPNQQRPPHVTTPCQHRPSHSQPLPPPHPYTRCPYCRRPLLTGSRDYEDNYDGYNYDYEDDYNEYDGRTRTSNYFNILAIANRTASEPSSSHLHLTLPNSNSNSPLTLKMANPSPPSPPTPHNENAKSPSTYHSDATAFPPSSMAEGYFDAFFRIEKKLGMEANGSVFLCQYVSDNNPLGCFTVKKVTVGQSHTRISYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LP17</accession>
    <name>A0A8H5LP17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_005647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000032">
        <property type="protein sequence ID" value="KAF5364700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LP17"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5364700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="364" mass="39673" checksum="50322F7FF609A13D" modified="2022-01-19" version="1">MAPRTKILLTGATGYIGGSILNRFLARPDFQSSFDIRVLVRSPEKAPKFDALGFKSIVGSHTDEEVMVQAVSEVDIVVGLTDCDSIPAAELTIKGLKKHFEETGKQAFFIQTSGTGVYVQLTNGMYTTDVIYDDANPDQIETLAPTQPHRNVDLKILSAENEGFFKSCIVLPSLVYGVATGPLFDSGLSNPHSILIPLMCRVALDRRRAGMIGQGKNVWPNVDINEVADFYPILIEKIIQSPDTVPHGREGIYNLENDKHTSYDVAEAIGKALVALGYGDDSTPLTFTPEEEKKYFGAHVHLIGSDCRCIATRARSFGWDPKLTTADMLGGVQKEIEILIKTGKAELKHFVSGVDPGNIQVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LRM0</accession>
    <name>A0A8H5LRM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_006484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000021">
        <property type="protein sequence ID" value="KAF5366846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LRM0"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034442916" description="CNNM transmembrane domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5366846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="515" mass="55982" checksum="639D2352477B6B5C" modified="2022-01-19" version="1">MRSSSLLLTYILPSALALPFSLFKSSIPQNLFRIAEAEEETPEYGSPEFWWKLCISGFLVLLGGVFAGLTLGLMGLDELHLRVLAQSSDEPKEKENAKKVLKLMTKGRHWVLVVLLLGNVIINESLPIFLDGAIGGGVAAVAISTTAIVIFGIIPQSLSVRYGLSIGAVCAPFVLCLMWLMFPIAWPIAKLLDWLLGANETHTYKKAELKSFLQFHRQGEEPLRDDEISILNGVLELNTKKVETIMTPMKDVVTLSSDTIMDHKTVDGLLLSGYSRFPVHEPGNPLAFVGLLLIKKLIQYDPAQALPVSDFHLSILPEAPPSINCFQALDYFQTGRAHILLISSSPGYAGGAVGVITLEDIIEEIISEEIVDETDRYQDNVSKQKAKRATNAAIMRGIVEREQRRRDSTLSFTSVIVNDPENTGKVPTTPSLASVMNYAATSGVVNGAGSKLGTPVRGGNKGGSKIGSRRNSIGGHDSRSRSRSPGSGEDGLELPTDERMPLLRPLSESPVSHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LT34</accession>
    <name>A0A8H5LT34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_002288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000015">
        <property type="protein sequence ID" value="KAF5368379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LT34"/>
    <dbReference type="OrthoDB" id="2976199at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034378218" evidence="2">
        <location>
            <begin position="23"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5368379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="415" mass="46577" checksum="F1C15FEA418DC861" modified="2022-01-19" version="1">MKIFTALLFLLYLLWFWSSGSGVCSSTSISPLLSFNNPVGSTSSVYLIKACNLFLFPFYLPPSPPLFLFAALPFTMTEYDFSPEAYEAYQKKIKGVERWAAETSRFNGDFASPFAPSLSTARRQLNNDSSTSSSSSDSESGITSYSRKSRPVYPKSLAQWSGPRSRAPPPRPLQLPHPPPASPLGQMPPPARSHTLPNQGYVQTSSPGIPQAQPQYPYPAQRPGPVVYYPAPAPQPVIPQQQQQTYVPPYYVSPVPKRSNTTPSRPLAYQYPYGTPVNSAGASPYPTPVTSPYGSRPTSPRAPGKNWLSRMFGALSIRGRSASPAPMSYNEPAMRHQRSRSLGPTGLRSDRERDRERDRTLSDQAQRSRSTRSARPRHRRHSDESDGERVHRRHRDRGRERERDHHRRARSVDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LU53</accession>
    <name>A0A8H5LU53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_001042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LU53"/>
    <dbReference type="OrthoDB" id="3358904at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5370115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="160" mass="17936" checksum="AE321A4C08EC1A61" modified="2022-01-19" version="1">MDSLHIAPSLSTIMAATNDSEFPELHPEQNPPTDYGIFVISTMKRMPPHRIDQTILRKCIGLSPSYLIADTCMNPEHGVSTWFVGFSRLIDLVVALHAKNELEIETMNAASRACSECWSVAGCWRGLEECREGVKKVALKLQRLLDENGRTYKGERVYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUK6</accession>
    <name>A0A8H5LUK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D9758_001309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5369984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUK6"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF5369984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="489" mass="51995" checksum="9F75ED665C2EC078" modified="2022-01-19" version="1">MATAPPITHPLPPKPETQNPTTSPSPSPSSQLRNERSEQEHPNFQTEGDGDSDLGIGKRTPKPTTCQTCHSQPAKYTCPRCGHVSCSVGCVKRHKEGGLTITSSGGYPTPISVSGSIGIGSTSTSFQPNVQQVEVEVVGCSGIRNKASYVPMSTYGWGEMMGDYVFLEEVGRVVKGGGEGIVKIGGGGAGAGAGMHTFTGSGIGSETGRGRGRGRGLGLGRGGGTRGGRHHQHKPRSKRELLKLELEKRDITMELVPLGMERGKVNMSCLDYKSQPPQPLLTIELVFHPTPDPLHPNESKEPYKVLRHRISLEDTVESVLCSLVSVKDKENQNGQGKGKGKGKEKTTTPSWVADLVGTGEAKEVAGGVLSTDSDVGLGLEVDCLIRAPALGKSKVYWRLDTQKTLKDALKGMEFVEFPTVEVWEKGVFGGKVVEVGEVGLNSNVNANRGFGFGFGVGVGVGGVVTGEDGIMRKERVREEGLWVKKRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUL5</accession>
    <name>A0A8H5LUL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D9758_001405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUL5"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="75"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF5370162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="676" mass="75318" checksum="8AB284A0545ADABE" modified="2022-01-19" version="1">MASLARLRLARRFPRASFVRTIQTSADTTQLQDSAHDSEPFTVKIHEDSFRAYNCEIPELTLQVTKSELLKMYKEMTTMRRMEMACDALYKAKMIRGFCHLAIGQEAVSVGLEHGITKEDLVITGYRCHPFAVLRGGSIKGVIGELLGRQGGMSHGKGGSMHIFTPTFFGGNGIVGAQVSVGAGLAFAQKYNEKPNCSFALYGDGASNQGQVFEAFNMAKLWDLPCIFVCENNKYGMGTSAERSSSNTEYFTRGDKIPGLQVNGMDIIASKQAVQYARKWAVEDKKGPLLLEFVTYRYGGHSMSDPGTTYRTREEVQRMRSTQDPIRGLQKYIEEWGLASEAELKQFDKEAKAEVEAAVEEAKASPEPLAKDLWTDIYYAGTEPSFMRALLLSISASAAPSEPLEKRQDPWNPPSNLVQGLNEVWSHTMQTYNGGNALDYFNYGWDIVMANKGALNYCVRPDTSRTVDAATRANIQTALNRSINKWNSWVAGWNGWPYSNIPFKVVGYAVRDHNQLTGDTTGLDIYTDKDADGILQCAEACGGGRLMNSHADMSVWPTDGFGGGAGGDWGQRLDADYFFSNLNLDNIHILLHEMGHTFALDDFYDWTPTGVTNFIMKADSATQITDFDDWMLRDWWRHIKSRYGVSLTDNTIGNATAIEERTQDSVLNFDDSQIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LUU8</accession>
    <name>A0A8H5LUU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_001420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000012">
        <property type="protein sequence ID" value="KAF5370161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LUU8"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5370161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="383" mass="43621" checksum="F5116C5CB98C4711" modified="2022-01-19" version="1">MAPRKRRATANTTSAFMRNATTTWATTTASNTSTSTKGNSRRKSPFGFERFRRDEFIDLSSGFTPLDTFETYFDSQITYLFQRQLNTARMSYARERQTHYKDACGQPQYQDIRKSKMEGYFGQGFPAFDEELFDSGGLLAENSDREFKGFKINHEYLNCPTRAWHSVKVVQTREKVSFFWFHVGVVPMGSHSLTPSPLSPSLRTYIYKKTRLVLLPLRPPCFYVTILSFIYLWISPALRALFVACSCLSHGSLASAKLLPKHRREIPCIQKIASSKSFTRVSGGIYFSWQLLYWKFALIDCREKIESGQRTTSFSFLLNNQRGIIGRSLSAISPQSRIAAFMGGQLVYMVLTELPAVFLCVQAAYEFENISGAEERAILKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVL0</accession>
    <name>A0A8H5LVL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D9758_004126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVL0"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF5371167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="238" mass="26617" checksum="B37D8DD2C488CAD0" modified="2022-01-19" version="1">MQISFSFSAMGFGYMIEHMEEDDETSKGVPPWVELEYAHMRTLAGQGSHVHFTHLSSSSSESLKVKFANMPEGENLSEASCHQAGVLDLIKERLGGSLEKVCLLDPKAEKELSPEDGDGRFEWFLFGDDPPRDRTAELRVLGFPGRRLGPVQMTTDTALGVTKRVVQDKIPLDKIPYIDFPTVTFNAKCLLLGLTIAIYYPVRAGKRRDAIPLHGERQPTHPPTRDARATVRGFEQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVM0</accession>
    <name>A0A8H5LVM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_004099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVM0"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="296"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF5371198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="521" mass="57365" checksum="C8B70F0773CCB333" modified="2022-01-19" version="1">MTEKSPIADEQVNADCPDQSGMSRGSSQKILWDNGFWITIGRLVKEYKQRFLLGTNRGIQHPSRSEEAAFCRPALFFSYPMSSSSTSPELTTKRKKILQDDSPDECDSASSDSESQHEPDEVEADEDEAPPLSHAEKRRQKKEKKEKESREPAKKKRKLADGKAKTSDPDKKHPTRQNSVWVGNMSYKTTPDALRAFFDGVGEITRINMPTKPSGRPGVPGENHAKTIAITLSERPLNGRKLLIKDGDSFEGRPKPAAADQSTGGADDQTHASTSTKSLSKTAQKILNQQKKPPAPTLFLGNLPFETTEESLRELLDAHQPKAKKGDKEKVKDGEAKKEDWIRRIRLGTFEDSGLCKGFAFVDFSGIEHATSALVNPRNHTFNGRKLVVEYASTEAVRRGPNKPKAEGHDTEGRGRGNGKSPRGVKHERNDKSRKSFSESDEWNPAAVPGDEHDQGDRYAQEAGQSRDSGAKRTRRDGTNHPNGKGPRGRPKPGAALAQAVRQSAAIVTNSNAASKKIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LVQ2</accession>
    <name>A0A8H5LVQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_004266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000009">
        <property type="protein sequence ID" value="KAF5371303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LVQ2"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5371303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="529" mass="58908" checksum="3A610E143280B52D" modified="2022-01-19" version="1">MLLPSGVMSGIISAPQFFRIFPDLNPDNVGSDHASTMQAFYTAIYEVGCLAGATFALLWGNKLGRRKNITIGAIFVIIGTIIQITPMPGKRAGHQFVIGRIVTGFGNGLNTATVPSWQAECSKAHNRGLHICIEASMIATGTVIAYWIDFGLSYLDNSISWRLPIGLQIIFAVIVIIGIWYLPESPRYLLSTGQYEEGEHVVAALADEPVDSPNTQLQKRLIVDALDNFGELQIKHVLTGGPSQHWRRTLIGASSQLFQQIGGCNAVMGKRSRANFVPYSPVIYQQYIGLDRRMSLILGGVNSTVYAMSAFLSYPMIERLGRRKMFLLGTFGQALAMFLAAFCLIPNDLQGDSNNHAVYGAVVGLFLFLISFGCTWLELPWLLPAEINPNAIRTNANAISTQTNWIWNFAVVMWTPPMLNSIKGFGTFMFFGCVNLCFFPIIYFYYVETRGRTLEEIDIIFAKAYCEKKWYVRVGNEMERLSPEEVERAAVKYGLSTEGSVREFGEDQGITYEHDKREVQKEAERGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX60</accession>
    <name>A0A8H5LX60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX60"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5372862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="763" mass="85691" checksum="EF9705F465C48934" modified="2022-01-19" version="1">MYSSFRRYLGDLREETLLGSIRDSLASVKVQKFQLVTLDPHPKDGGVFVRFKYQASNEDHALKTIKEEIEKCFVESGGVSSWIGRRRTKVWVVQGNPWPEDMNRFASKMIKISFDGPDVPEEALYSLLRPYGRISDITDVGPAPAGTLRSTTVNFERLKAATIARNTIHGLSVQVPGGSTTRLRLLTVYIPEFKLYKWLKANTLERLYTPAPSVLPSEEVWQERKDAKDAIRAYLTDQPTTVAFVHGPQGSGKTTMVESVTKECNRNRLLKIMWKEDPRNRLSRTAEIQTGYRPVFSFLNSMNNLVDLASVGLIGQKAGFSSSIEEQLQQTLDIVATALKKVGALHREQIEKEMEKRDKEGGSSKESKRPQQDSTKGRSQDHDGRRGYVAGNGVMSELGVGDEKINDEAAREGKRENRGEEKEDGNKRQKNDVKASEPLPVVVIRSYASKGGLRREEIMNVIASWAARLAESQASLKRLASRLRAGAEFLMMTIFSALPSKPLNYIALYDADSSNALSFVKQKLHRNNADLGLTDEDTAYVERLGGRSSDLESLVYKVDTGASIKDAVEDIINRGVGELRKNAFGDDAEDAKNLPWTREQAWSVMKNLAKDGQVWIDLIPYYDVLFNFPFKGDESALRSMEEAELINIATHNGRPSVIRPGRPVYKYVFERLVNDPIFRATQEITYNEKLIAAATETIKSCEVELLSLKEIRTAFSRYSIWRDPANNRANYLLGQMHNAESTLQKLQATNAELKKVFRTGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LX65</accession>
    <name>A0A8H5LX65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D9758_001550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JAACJM010000004">
        <property type="protein sequence ID" value="KAF5372877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LX65"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF5372877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="132" mass="14566" checksum="54CCBD546176342A" modified="2022-01-19" version="1">MPIVDFKTNVKIPNVEEYVKDLSKLSATLLGYPEEIICVSVLHDQPMSFKGTFDPTFLLSITLTESTPDNNSKLSAAYFEHFKKTLGIDDDRGYISFLDPGKSNLGFKGKTVEQLLSAPAEKGSMADLAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LY20</accession>
    <name>A0A8H5LY20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D9758_004705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000002">
        <property type="protein sequence ID" value="KAF5374255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LY20"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034334319" description="Cyclase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF5374255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42437" checksum="1F45DA1BDB3207BA" modified="2022-01-19" version="1">MMLHTRYSLALLGLCAWFSFQVYGRPTHKPTTAGIHVSRQFDSSDMYVNWPTYDELPRDPSFPTKAAWGVWGPKDELGALNHITSATIEAAKEEIKEGIAISMNLELEIPNPPMNPLRPELIHAVIPFEGYQDDMISLNTQVSTQFDGLRHYPYSTAGNISTYQFYNDLITFDDIVSPARIKTLGIQNAAQKGIAGRGVLLDWAGWKESKNETFDAFSFFNITTSDLDSVASWQNLPSNFTRPGDFLIIRSGFMKQYSLLPINQEQVLPFRAGDDAAWIGLEPNEETLRWIWEKKISLLGSDDPSIEPHPENSVIGGVKRNLHQIFIGGWGMSLVEFLDLETLAQTCHKLNRFTFFFTLQNLNMAGGIASPPNAMAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZ22</accession>
    <name>A0A8H5LZ22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D9758_000336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5374812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZ22"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF5374812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <sequence length="356" mass="39957" checksum="0B765C2FCBFD2B24" modified="2022-01-19" version="1">MMSVPRDFVVPFEGMEGILIDHNLCQCTSHSTSCILHNLARFFYENIQPDWEASNSSRKPPWPSSSRSTQSLVGPAHGLDMSEGEGIGIGRCVVVLAGGLSGGHKAEVLGAMFIVPQMDRAVKIWHFPPFPDDRLAREDKPLFSSTLIHKARVISVSWLNDDTLLTHSAPAVLSDDCGDDEQTPLRLEPGTVVLWRWTGLERFFPAHWDRRQRNFLGCASDYQESSSFKILSSYFLPPQETQYEAVSLSVTLDTGDPLILCTLPRSSVMKIVNITHWEPRREPQEPARNLQSFILSSRARLLDDPNDSQGWKVEIDHRYTELPDKEPEFIESCMMCLGGSMIIAGGSRGSLWVWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZM6</accession>
    <name>A0A8H5LZM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D9758_000183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
            <title>Uncovering the hidden diversity of litter-decomposition mechanisms in mushroom-forming fungi.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Bentzer J."/>
                <person name="Ahren D."/>
                <person name="Johansson T."/>
                <person name="Persson P."/>
                <person name="Tunlid A."/>
            </authorList>
            <dbReference type="PubMed" id="32382073"/>
            <dbReference type="DOI" id="10.1038/s41396-020-0667-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 291.85</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAACJM010000001">
        <property type="protein sequence ID" value="KAF5375246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H5LZM6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000559256">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF5375246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000559256"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47801" checksum="28885BC23FE56536" modified="2022-01-19" version="1">MVTELMGWDWLFSLMQYGPVWKQHRNLFFKHFPVNTTAFHPVQIKESHILLRSLFLKPKDFLSDTRRSAAAIILQITYGIQIDEKVDEDGDNYVSLADKAMFSFGRAGLFGSFMVVRIAMLSALNFEIYILLSLKGLPANTETYAPLDAGGLIQKIGPSKMRNGVASPCIVASELEDIISGRAPQENERILKNVAATSYAGGADTTVSVLVSLYLVMTLYPEIQNKAQRQLDQVLEGRLPVFEDRPQLPFIDCICYELLRWNPVTPLGLNHYAMNDDENYLDPKCLGNTPRSVSHFSCVFAESLSSERYDHHRDVYPDPFTFSPERFENVEKNIAQGINEIPGAVFGFGRRICPGRWMAFDSIWIAVASILSVYRISKAVDENGKVIEPEVGYTSSLLSHPKPFQCSITPRSAEAAKLVLQTADQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H5LZN7</accession>
    <name>A0A8H5LZN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D9758_000156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tetrapyrgos nigripes</name>
        <dbReference type="NCBI Taxonomy" id="182062"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Marasmiaceae</taxon>
            <taxon>Tetrapyrgos</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2020" name="ISME J." volume="14" first="2046" last="2059">
      
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